objective order increase classification accuracy tea category identification tci system paper proposed novel approach method proposed methods first extracted color histogram obtain color information wavelet packet entropy obtain texture information aim reducing features principal component analysis harnessed reduced features used input generalized eigenvalue proximal support vector machine gepsvm winner takes wta used handle multiclass problem two kernels tested linear kernel radial basis function rbf kernel ten repetitions fold stratified cross validation technique used estimate sample errors named method gepsvm rbf wta gepsvm wta result results showed pca reduced features merely five explaining total variance recall rate gepsvm rbf wta achieved highest overall recall rate conclusion higher result gepsvm wta five state art algorithms back propagation neural network rbf support vector machine genetic neural network linear discriminant analysis fitness scaling chaotic artificial bee colony artificial neural network
ghrelin cells numerous since reports endocrine cells kinetics corpus human stomach limited aim study examine appearance localization density relationship among endocrine cell types corpus human stomach prenatal early postnatal development examined chromogranin somatostatin ghrelin glucagon serotonin expression immunohistochemistry embryos fetuses infants corpus human stomach chromogranin secreting endocrine cells identified corpus week gestation somatostatin cells present week ghrelin serotonin cells week glucagon cells week gestation endocrine cells present individually clustered within glandular base body first trimester present separately within basal central parts glands second third trimesters somatostatin cells common type cells similar first trimestercond trimester similar infants similar percentage glucagon cells significant first trimester pregnancy percentage serotonin cells significant birth results show first time largest number endocrine cells present corpus first trimester prenatal development also results suggest secretory products endocrine cells play role regulation homeostasis growth differentiation human stomach function
fluorocholine pet detect hepatocellular carcinoma hcc based imaging initial steps phosphatidylcholine synthesis relate diagnostic performance fluorocholine positron emission tomography pet ray computed tomography phospholipid composition liver tumors radiopathologic correspondence performed patients early stage liver cancer undergone fluorocholine pet tumor resection tumor adjacent liver profiled liquid chromatography mass spectrometry quantifying phosphatidylcholine species mass charge ratio clinical radiopathologic correlation hcc profiles reduced two orthogonal principal component factors pcf pcf accounting total profile variation tissues hcc patients intrahepatic cholangiocarcinoma icc patients analyzed revealing significantly higher levels phosphocholine cdp choline highly saturated phosphatidylcholine species hcc tumors relative adjacent liver icc tumors significant loading values pcf corresponded phosphatidylcholines containing poly unsaturated fatty acids pcf corresponded highly saturated phosphatidylcholines pcf correlated significantly hcc tumor liver fluorocholine uptake ratio rho sensitivity tumors based abnormal fluorocholine uptake ratio sensitivity hcc based increased tumor fluorocholine uptake lower levels highly saturated phosphatidylcholines tumors showing low fluorocholine uptake hcc tumors contain high levels saturated phosphatidylcholines supporting dependence novo fatty acid metabolism phospholipid membrane synthesis fluorocholine pet serve identify lipogenic tumors imperfect diagnostic sensitivity implies metabolic heterogeneity across hcc weaker lipogenic phenotype tumors
purpose study examined influence range motion ankle joints elderly people balance ability methods conducted four week experiment using elderly people used senior health facility subjects tetrax stability synchronization conducted measure balance ability examined correlations tetrax balance ankle joint rom student test pearson correlation coefficients used statistical analyses results significant correlations measurement items tetrax stability synchronization movement ankle joint conclusion found plate stable measurement using ankle joint rom tetrax closing eyes balance maintained dorsi flexion
many factors affect performance active power filter key factor command current tracking control aiming deficiency traditional controller paper puts forward improved controller vector resonant controller controller advantages stronger anti interference ability greater gain resonance point improve accuracy harmonic compensation current compensation control paper digital controller digital control system given detailed design finally experimental results show control strategy reduce harmonic content improve compensation accuracy
beta hydroxysteroid dehydrogenase deficiency consists defect last phase steroidogenesis androstenedione converted testosterone estrone estradiol external genitalia range female like atypical genitalia affected males raised females virilization subjects beta hsd deficiency occurs time puberty several change male social sex male social sex patients testes safely maintained long positioned inside scrotum phenotype dsd due beta hsd deficiency extremely variable clinically indistinguishable causes dsd partial androgen insensitivity syndrome alpha reductase deficiency laboratory diagnosis based low testosterone androstenedione ratio due high serum levels androstenedione low levels testosterone disorder caused homozygous compound heterozygous mutations hsdb gene encodes beta hsd isoenzyme leading impairment conversion keto hydroxysteroids molecular genetic testing confirms diagnosis provides orientation genetic counseling proposal article review previously reported cases beta hsd deficiency adding cases published elsevier ltd
alpha ethinylestradiol used birth control humans potent estrogen found wastewater low concentrations ability interfere endocrine system fish affecting reproduction result population level effects objective study determine dietary exposure would alter gene expression patterns key pathways liver ovary whether could associated reproductive endpoints female large mouth bass egg development female lmb received feed administered body weight days dietary exposure significantly reduced plasma vitellogenin concentrations hepatosomatic gonadosomatic indices also decreased feeding respectively transcriptomic profiling revealed changes steady state mrna levels liver compared ovary genes associated reproduction differentially expressed vitellogenin liver aromatase gonad addition set genes related oxidative stress glutathione reductase glutathione peroxidase identified altered liver genes associated immune system complement component macrophage inducible type lectin altered gonad follow study feed days similar phenotypic gene expression changes observed support findings higher concentrations study provides new insights dietary exposure interferes endocrine signaling pathways female lmb critical period reproductive oogenesis elsevier rights reserved
year creation bitcoin network consisting decentralized database storing transactions bitcoin tokens whose quantity predetermined protocol independent authority aim article describe limits use bitcoin medium exchange bitcoin network operation carried high costs electrical energy consumption time reflected price transactions low transaction prices one main arguments bitcoin promoters possible continuous issuance new bitcoins circulation bitcoin prove work energetically demanding method currently existing methods securing cryptoplatforms halving mechanism reduces rewards miners create pressure decrease hash rate reflection rate network security pressure decrease hash rate overrun increasing efficiency mining devices future therefore probably bring fundamental questions mean bitcoin network real costs running network reflected costs transaction bitcoin network able compete cryptocurrencies whose operation carried much lower cost halving mechanism ultimately cause declined hash rate thereby also reduction network security
deletion syndrome wide range clinical features including endocrine abnormalities aimed characterize growth patterns hypoparathyroidism thyroid dysfunction individuals anthropometric laboratory measurements obtained charts individuals males visits participant followed national clinic age diagnosis years age last evaluation years median height sds negative ages height sds last visit correlated midparental height sds yet participants reach target height difference height sds last visit participants heart defect lower compared participants normal heart lower height sds subgroup participants severe heart defects mean igf sds low correlated height sds thirteen patients hypoparathyroidism presented infancy adolescence five patients female thyroid abnormalities conclusions individuals distinct growth pattern consisting growth restriction ages resulting final adult height low normal range hypoparathyroidism common may present neonatal period well later life thyroid abnormalities may present childhood adolescence adulthood
year old male rugby player presented severe onset right hip pain fell awkward ruck international match rare case acute strain obturator internus muscle deep muscle hip joint reported resolved completely period rest intense active physical therapy
network chip noc enables design high performance low power many core chips existing nocs inadequate meeting ever increasing performance requirements many core processors since simple extensions regular architectures fully exploit advantages provided integration moreover anticipated performance gain noc enabled many core chip may compromised due potential failures silicon vias predominantly used vertical interconnects address problems propose machine learning inspired predictive design methodology energy efficient reliable many core architectures enabled integration demonstrate small world network based noc swnoc performs significantly better mesh based counterparts average swnoc shows energy delay product improvement mesh parsec splash benchmarks considered paper improve reliability noc propose computationally efficient spare vertical link svl allocation algorithm based state space search formulation results show proposed svl allocation algorithm significantly improve reliability well lifetime swnoc
year old woman diagnosed hypopituitarism following acute presentation cardiac tamponade hyponatraemia recently investigated pericardial effusion secondary hypothyroidism rare cause pericardial effusion tamponade important differential consider management requires appropriate hormone replacement critically low threshold commencing stress dose steroids clinical signs classically associated cardiac tamponade frequently absent cases tamponade due primary secondary hypothyroidism relatively volume deplete state secondary hypoadrenalism hypopituitarism may mask evolving tamponade rise right atrial pressure less marked even presence large effusion case demonstrates importance high index suspicion cardiac tamponade patient cohort even absence clinical signs measuring thyroid stimulating hormone thyroxine levels evaluating pericardial effusion
year old man presented progressive dyspnoea weight loss physical examination revealed mild pale conjunctiva workup showed mild anaemia mild impaired renal function high globulin level multiple myeloma excluded normal serum protein electrophoresis chest radiography computed tomography revealed bilateral multifocal patchy infiltration mediastinal adenopathy bronchoscopy performed bronchoalveolar lavage bal fluid examination negative infection malignancy tissue pathology revealed diffuse lymphoplasmacytic cell infiltration immunohistochemistry revealed positive highlight immunoglobulin igg igg serum igg subclass requested showed igg level examination bone marrow submental lymph node pathology also positive igg igg related disease pulmonary involvement diagnosed treatment prednisolone day resulted improvement dyspnoea almost complete resolution pulmonary infiltration repeated month case highlighted rare occurrence igg related disease successfully treated steroid
back electromotive force based sensorless technique surface mounted permanent magnet synchronous motor drives considered paper model observer developed laplace domain represents original approach respect state art proposals normally employing state space representation allows intuitive equivalent design observer gains based standard frequency response compared eigenvalues analysis moreover steady state errors obtained theoretical point view including effects common nonidealities affecting drive system parameters sensitivity full simulation experimental characterization sensorless drive provided reference general purpose industrial drive transient steady state meaningful speed torque operating conditions
blanking method punch sheet metal without burr presented method divided two stages preloading deformation blanking fem software deform used simulate blanking process burr free stainless steel aisi changing size relative clearance analyzing quality cross section blanking process result shows clearance effect blanking force length shear zone provides certain fundamental predicting defects blanking pieces designing molds method important application value manufacturing engineering
bwr based smr called novel modular reactor nmr developed purdue university nmr takes advantages two phase flow driving head allows much smaller simpler reactor pressure vessel rpv compared integral pwrs study systematic stepwise optimization approach including simulated annealing based optimization method optimum core design meets year cycle length minimum fuel cost satisfying safety related criteria derived analyzed lattice code casmo whole core analysis code parcs thermal hydraulics code relap used perform calculations pin cell whole core depletion calculations nmr optimized core design able achieve year cycle length average fuel enrichment lattice fuel assembly minimum critical power ratio mcpr maximum fuel linear power density mflpd cycle respectively providing large margins thermal design constraints nmr control system design able provide sufficient cold shutdown margin small reactor core size large negative void coefficient low operating thermal neutron flux enhanced xenon stability characteristic possible peak fast neutron fluence industry standard limit extensive plant data records major concern channel distortions radiation damage point view elsevier ltd rights reserved
central idea distance based machine learning algorithms nearest neighbors manifold learning choose set references neighborhood based distance functions represent local structure around query point use local structures basis construct models local partial least square local pls result applying neighborhood based idea partial least square pls shown perform well regression small sample sized multicollinearity data seldom used high dimensionality classification furthermore difference pls local pls respect optimal intrinsic dimensions unclear paper combine local pls non euclidean distance order find measures better suited high dimensionality classification experimental results obtained uci spectroscopy datasets show euclidean distance good distance fiinction use local pls classification especially high dimensionality cases instead manhattan distance fractional distance preferred experimental results show optimal intrinsic dimension local pls smaller standard pls
challenging task automotive electrical traction drives control speed synchronous machines due existing physical computational constraints goal paper find control solution answer problem end multirate predictive cascade speed control structure suitable real time implementation proposed focus paper design outer loop controller first suitable mathematical model outer loop plant includes also dynamics inner control loop obtained second one step ahead state feedback model predictive controller based flexible lyapunov function concept employed control rotor electrical speed third state disturbance observer employed estimate load torque unmeasured state ensures also offset free operation closed loop system illustrate effectiveness proposed control solution implemented real microcontroller tested real time industrial hardware loop test bench real traction test bench
combined cooling power ccp system developed comprises brayton cycle organic rankine cycle orc ejector refrigeration cycle cascade utilization waste heat internal combustion engine establishing mathematical model simulate overall system thermodynamic analysis exergoeconomic analysis conducted examine effects five key parameters including compressor pressure ratio compressor inlet temperature turbine inlet temperature orc turbine inlet pressure ejector primary flow pressure system performance single objective optimization means genetic algorithm carried search optimal system performance viewpoint exergoeconomic results show increases turbine inlet temperature orc turbine inlet pressure ejector primary flow pressure benefit thermodynamic exergoeconimic performances ccp system however rises compressor pressure ratio compressor inlet temperature lead worse system performances single objective optimization lowest average cost per unit exergy product overall system obtained elsevier ltd rights reserved
common assumption implicit measures reflect early experiences whereas explicit measures assumed reflect recent experiences assumption subsumes two distinct hypotheses implicit measures resistant situationally induced changes explicit measures individual differences implicit measures stable time individual differences explicit measures although first hypothesis subject numerous studies second hypothesis received relatively little attention current research addressed second hypothesis two longitudinal studies compared temporal stability individual differences implicit explicit measures three content domains self concept racial attitudes political attitudes studies implicit measures showed significantly lower stability time weighted average conceptually corresponding explicit measures weighted average despite comparable estimates internal consistency implications theories implicit social cognition interpretations implicit explicit measures discussed
common feature ambient intelligence many objects inter connected act unison also challenge internet things shift research towards integrating concepts considering internet things representing future computing communications however efficient combination management heterogeneous things devices ambient intelligence domain still tedious task presents crucial challenges therefore appropriately manage inter connection diverse devices systems requires specifying efficiently implementing devices services handling verifying heterogeneity composition standardizing managing data tackle large numbers systems together avoiding standalone applications local servers overcome challenges paper proposes platform manage integration behavior aware orchestration heterogeneous devices services stored accessed via cloud following contributions describe lightweight model specify behavior devices determine order sequence exchanged messages composition devices define common architecture using service oriented standard environment integrate heterogeneous devices means interfaces via gateway orchestrate according behavior iii design framework based cloud computing technology connecting gateway charge acquiring data devices cloud platform remotely access monitor data run time react emergency situations implement generate novel cloud based iot platform behavior aware devices services ambient intelligence systems validating whole approach real scenarios related specific ambient assisted living application
common issue many system identification problems true input system unknown paper extends previously presented indirect modelling framework deals identification systems input partially fully unknown framework unknown inputs eliminated using additional measurements directly indirectly contain information unknown inputs resulting indirect predictor model dependent known measured signals used estimate desired dynamics properties since input indirect model contains known inputs measurements could correlated disturbances output estimation indirect model similar challenges closed loop estimation problem fact due generality indirect modelling framework unifies number already existing system identification problems contained special cases completeness paper concluded one method used estimate indirect model well experimental verification show applicability framework
compact multilayer non commensurate section dispersive delay structure dds proposed analog signal processing asp applications contrast previously reported section dds uniplanar used edge coupled sections dds based broadside coupled sections hence achieves much larger ratio group delay swing frequency bandwidth leading higher asp resolution moreover much compact maintaining acceptable insertion loss parametric characterization mono block commensurate multilayer dds varied strip widths two multiblock non commensurate ddss linear group delay slopes demonstrated full wave simulation experimental low temperature fired ceramics results proposed dds exhibits significant footprint reduction factor around compared uniplanar edge coupled counterpart
company produces prefabricated stirrup cages reinforcement concrete process consists straightening cutting twin bending coiled steel bars custom produced machine punch cutting system failed repeatedly cutting edges lose functionality much earlier expected two representative pieces analyzed study included visual inspection chemical analysis hardness micro hardness measurements optical metallographic examination representative samples carried fracture areas analyzed using scanning electron microscope sem crack initiation propagation discussed punches failed chipping wear mechanism due low cycle fatigue repeating failures provoked faulty machine design problem solving suggestions proposed addition alternatives related material selection provided order reduce crack susceptibility economical way moreover conclusions recommendations useful resulting higher productivity prefabricated stirrup cages elsevier ltd rights reserved
complete numerical dynamic analysis reciprocating compressor mechanism presented coupling instantaneous pressure compression chamber electric motor torque hydrodynamic reactions arise piston crankshaft secondary movements additionally non constant crankshaft angular velocity piston crankshaft misalignment torques also considered two sensitivity analyses carried prove neither inertial forces directions secondary movements oscillations angular velocity produce significant differences compressor behaviour finally set parametric studies developed evaluate influence geometrical parameters stability secondary movements friction power losses compressor consumption
concept map heuristic offered tool teaching learning mechanics materials courses paper present literature review wherein list previous efforts improve mechanics materials learning use concept maps teaching provide common concept map detail several ways used heuristic finally describe preliminary results assessing efficacy
controversy arose decades ago whether gene product expressed frog embryogenesis synthesized hyaluronan chitin sets investigators correct possible understand prescient findings synthesis seven nine chitin sugar chain fragment required hyaluronan synthesis begins thus indeed synthesizes hyaluronan chitin hyaluronan turns rapidly vertebrate tissues chitin oligomers difficult degrade accumulate cause pathology chitin simple beta linked repeating sugar homopolymer found prominently building block structures fungi molluscs arthropods forms invertebrate life highly resistant insoluble material requiring chitin synthases production chitinases degradation mysteriously chitins chitinases also occur vertebrate tissues previously assumed chitins contained therein assumption challenged based recent biochemical evidence chitin accumulate many tissues may particularly toxic neurons accumulation brain may account cognitive decline found patients alzheimer disease observations together participation chitins chitinases several human diseases among addition alzheimer disease include gaucher disease asthma aspects abnormal immune recognition justify reexamination topics purpose review summarize data order place chitins attendant enzymes rational framework attempt create cohesive story
correlation based fluid mechanics investigated mean particle diameter crosslinked dextran microgels cdms prepared via water oil emulsification methodology conducted single stirred vessel end non dimensional correlations developed predict mean particle size cdms function weber number reynolds number viscosity number similar ones introduced liquid liquid dispersions moreover rosin rammler distribution function successfully applied microgel particle size distributions correlations validated using experimentally obtained mean particle sizes cdms prepared different stirring conditions validated correlation especially applicable medical pharmaceutical applications strict control mean particle size size distribution cdms extremely essential
critical aspect dimensionality reduction assess quality selected produced feature subsets properly feature subset assessment machine learning refers split given feature subset training set used estimate parameters classification model test set used estimate predictive performance model averaging results multiple splitting cross validation commonly used decrease variance estimator practice scheme computationally expensive paper propose new statistics index method called index evaluation feature subset dimensionality reduction algorithms general proposed method type classical statistics approach uses feature subset compute empirical estimate quality feature subset large number performance comparisons machine learning approach conducted fourteen benchmark collections show proposed index highly correlated external indices macrof microf svm centroid based classifier cbc trained five fold scheme furthermore experimental results indicate index performance traditional scheme evaluating dimensionality reduction algorithms efficient traditional methodology therefore one contribution paper present alternative methodology based internal index typically used unsupervised learning context computationally cheaper traditional methodology another contribution propose new internal index behaves better similar indices widely used clustering shows high correlation results obtained traditional methodology authors published elsevier
cumulative fatigue damage model presented estimate fatigue life high strength steels high cycle high cycle fatigue regimes fish eye mode failure simple formula obtained model takes account inclusion size fine granular area fga size tensile strength materials equivalent crack growth rate fga proposed model used estimate fatigue life equivalent crack growth rate bearing steel gcr present investigation four high strength steels literature equivalent crack growth rate fga calculated order magnitude cycle estimated results accord well present experimental results prior predictions experimental results literature moreover effect inclusion size fatigue life discussed indicated inclusion size important influence fatigue life effect related relative size inclusion fga inclusion size close fga size former substantial effect fatigue life relatively large value fga size inclusion size little effect fatigue life
daily black carbon exposure assessment forty years old children conducted seoul metropolitan area august january participant carried microaethalometer measure concentrations whereabouts microenvironments mes recorded via time activity diary tad follow interviews analysis variance anova employed compare average levels potential risk factors including demographic temporal residential indoor outdoor transportation activity variables children average daily exposure range mean daily individual exposure ranges even children attending elementary school reported exposures differed approximately primarily individually distinct time activity patterns mes child interacted weekends saturdays sundays holidays saturdays sundays vacation children subject reduced exposures likely due decreased surrounding traffic volumes different time activity patterns weekend days compared weekdays mondays fridays school days weekdays school semesters commuting diesel vehicles often private academies subway cooking environmental tobacco smoke found elevate exposure likewise proximity traffic sources parental indoor smoking contributed enhancement residential concentrations findings suggested need emplace proactive measures including diesel fleet regulation smoking cessation campaigns protect children high levels exposure elsevier ltd rights reserved
detailed transformation process cation exchange chemistry hexagonal phase cds cds cus core shell heterostructures nanorods eventually monoclinic phase cus nanorods reported applications nanorods environmental pollution removal photothermal conversion light induced water evaporation investigated influence reaction time morphology crystal phase photocatalysis photothermal conversion light induced water evaporation discussed results showed maximum removal value rhodamine timepoint aqueous dispersion core shell cds cus heterostructures nanorods prepared exhibited good photothermal conversion performance saw increase sample temperature circle irradiation laser exposure obtained sample film simulated sunlight irradiation increased weight loss pure water min water evaporation efficiency reporting excellent light induced water evaporation performance potential nanorods discussed
digitally controlled operational amplifier amp level crossing based approximation proposed high gain effectively obtained means damping control without stability problem occurring multiple gain stages compared previous version zero crossing based algorithmic approximation proposed scheme improves settling time class operation obtained switching multiple driving paths verification designed amp applied bit pipeline adc implemented cmos technology measured results show designed amp successfully operates bit resolution msample pipeline adc achieves effective gain
dimension splitting method dsm crank nicolson time discrete strategy three dimensional heat equation proposed basic idea simulate three dimensional problem numerically solving series two dimensional problems parallel fashion convergence error estimation dsm scheme derived paper numerical experiments demonstrate feasibility efficiency dsm scheme copyright john wiley sons ltd
disruption oxytocin system seems affect variety brain functions including emotions mood social behavior possibly underlying severe social deficits susceptibility substance use mental health disorders early life adversity insecure attachment childhood suggested influence oxytocin tone contributing condition neurobiological vulnerability aim present study investigate oxytocin serum levels abstinent heroin addicted patients comparison healthy controls possible correlation occurring psychiatric symptoms aggressiveness perception parental neglect eighteen abstinent patients affected heroin use disorders control subjects never used drugs abused alcohol included study submitted collection blood sample oxytocin assay symptoms check list psychiatric symptoms evaluation buss durkee hostility inventory measure aggressiveness child experience care abuse questionnaire retrospectively test perception parental neglect heroin exposure extent heroin dosages also recorded oxytocin serum levels unexpectedly significantly higher among abstinent patients affected heroin use disorders positively correlated psychiatric symptoms aggressiveness mother neglect scores correlation evidenced oxytocin heroin exposure extent dosages findings appear contradict simplistic view oxytocin pro social hormone confirm previous evidence concerning peptide levels direct association aggressive behavior mood disorders considering complex mechanism oxytocin would increase sensitivity social salience cues related contextual inter individual factors promoting pro sociality safe conditions contrast inducing defensive anti social emotions behaviors social cues interpreted unsafe latter condition often characterizing clinical history addicted patients elsevier inc rights reserved
distributed denial service ddos attack austere menace extensively used internet based services time detection ddos attacks poses tough challenge network security revealing low rate ddos ddos attack comparatively difficult modern high speed networks since easily conceal due similarity legitimate traffic eluding current anomaly based detection methods paper investigates aptness impetus information theory based generalized entropy generalized information distance gid metrics detecting different types ddos attacks results gid metrics compared shannon entropy popular information divergence measures addition feasibility using metrics discriminating high rate ddos ddos attack similar looking legitimate flash event also verified used real synthetically generated datasets elucidate efficiency effectiveness proposed detection scheme detecting different types ddos attacks fes results clearly show gid metrics perform well comparison metrics reduced false positive rate fpr elsevier rights reserved
diversity synthetic cathinones flooded recreational drug marketplace worldwide variety often response legal control actions one specific compound methcathinone resulted emergence closely related replacement based recent trends nitrogen atom one sites cathinone molecule explored designer type modifications study designed synthesized two new synthetic cathinones alpha piperidinopropiophenone pipp alpha piperidinopentiothiophenone pivt piperidine ring substituent nitrogen atom thereafter evaluated whether two compounds abuse potential conditioned place preference cpp mice self administration rats also investigated whether substances induce locomotor sensitization mice following days daily injection challenge qrt pcr analyses conducted determine effects dopamine related genes striatum pipp induced cpp mice pivt however synthetic cathinones self administered rats induce locomotor sensitization mice qrt pcr analyses showed pipp pivt reduced dopamine transporter gene expression striatum data indicate pipp pivt rewarding effects may attributed ability affect dopamine transporter gene expression altogether study suggests pipp may abuse potential careful monitoring type cathinone related drugs advocated
facile controllable inexpensive green electrochemical synthesis iro graphene nanohybrid thin films developed fabricate easyto use integrated paper microfluidic electrochemical sensor resource limited settings taking advantages meters strips sensing platform composed hydrophobic barrier patterned paper micropad pad using polydimethylsiloxane pdms screen printed electrode spe modified iro graphene films molded acrylonitrile butadiene styrene abs plastic holder repetitive cathodic potential cycling employed graphene oxide reduction completely remove electrochemically unstable oxygenated groups generate defect free homogeneous graphene thin film excellent stability electronic properties uniform smooth iro film nanoscale grain size anodically electrodeposited onto graphene film without observable cracks resulting iro rgo electrode showed slightly super nernstian responses britton robinson buffers good linearity small hysteresis low response time reproducibility different buffers well low sensitivities different interfering ionic species dissolved oxygen simple portable digital meter fabricated whose signal measured multimeter using high input impedance operational amplifier consumer batteries values measured portable electrochemical paper microfluidic sensors consistent measured using commercial laboratory meter glass electrode
fatigue testing setup based electromagnetic excitation built apply cyclic stresses specimens near resonance frequency test near resonance frequency advantage higher stresses applied test specimens reduced input power stress amplitude mpa applied test specimens four specimens tested simultaneously setup test specimens high fatigue cycle regime million stress cycles achieved hours setup used study effects internal external microstructure fatigue strength materials specimens especially stainless steel prepared different techniques electric discharge machining edm etching laser cutting specimens prepared techniques tested fatigue strengths compared probe material endurance limit tests also performed mentioned steel specimens high stress cycle regime cycles order investigate effect internal microstructure fatigue strength material cuzn fabricated etching tested effect different grain size fatigue strength compared curves plotted materials prior fatigue strength data stainless steel specimens prepared rapid prototyping tested fatigue analysis test results showed higher degree scattering compared traditionally manufactured steel fractography revealed existence inherent material flaws main reason higher degree test point scattering addition data curve plotted innolot important soldering alloy prompts fatigue failure electronic assemblies
feasibility study performed order demonstrate benefits designing manufacturing customized foot orthosis means digital technologies reverse engineering generative design additive manufacturing aim work define complete design manufacturing process starting scanning human foot anatomy direct fabricating customized foot orthosis moreover first methodological study tries combine user friendly semi automatic modelling approach use low cost devices laser scanning printing processes finally result approach based digital technologies also compared achieved means conventional manual techniques
female captive bred juvenile swell shark cephaloscyllium ventriosum observed swimming tight circles rolling radiographs computed tomography individual revealed extensive cartilage mineralization skull cranial cervical vertebrae compared diagnostic images clinically healthy conspecifics gross necropsy histopathologic examination revealed ossification fibrosis cartilaginous matrix skull cervical vertebrae deep invasion pigmented hyphal fungus growth fungal culture fungal polymerase chain reaction identified dna sequence compatible exophiala radiographs computed tomography helpful determine prognosis course action individual case emphasizes need include fungal infections differential diagnosis evaluating elasmobranchs abnormal swimming behaviors mineralization skeletal structures
field experiment examined whether increasing opportunities face face interaction eliminating use screen based media communication tools improved nonverbal emotion cue recognition preteens fifty one preteens spent five days overnight nature camp television computers mobile phones allowed group compared school based matched controls retained usual media practices groups took pre post tests required participants infer emotional states photographs facial expressions videotaped scenes verbal cues removed change scores two groups compared using gender ethnicity media use age covariates five days interacting face face without use screen based media preteens recognition nonverbal emotion cues improved significantly control group facial expressions videotaped scenes implications short term effects increased opportunities social interaction combined time away screen based media digital communication tools improves preteen understanding nonverbal emotional cues authors published elsevier ltd
flexible synthesis procedure nth order current mode low pass filter using current controlled current differencing buffered amplifier cdba given proposed method based drawing signal flow graph given transfer function obtaining circuit realization graph proposed configuration uses cidbas capacitors straightforward find values passive elements coefficients transfer function realized undamped natural frequency quality factor adjusted electronically without changing values passive components proposed structure uses cascade connection second first order filter sections therefore carries general advantages type structures current ratio transfer function shown realized adding weighted summer without affecting basic configuration simulation results fourth order band pass elliptic filter included verification theory
fully integrated low dropout regulated step multiphase switched capacitor converter charge pump fast response adaptive phase fast rap digital controller designed using cmos process different conventional designs low dropout regulator ldo nmos power stage used without need additional step driving clock tripler pulse divider proposed enable fast rap control fast rap digital controller designed able respond faster cascaded linear regulator transient response affected adaptive scheme thus light load efficiency improved without sacrificing response time operates mhz efficiency small ripples would appear output phase interleaving scheme attenuated vout dropout regulator efficiency overhead area overhead output ripple less load current
fundamental challenge digital control arises controlled plant subjected fast disturbance dynamics equipped relatively slow sensor intrinsic difficulties however commonly encountered many novel applications laser electron beam based additive manufacturing human machine interaction etc paper provides discrete time regulation scheme exact sampled data rejection disturbances beyond nyquist frequency introducing model based multirate predictor forward model disturbance observer show inter sample disturbances fully attenuated despite limitations sampling sensing proposed control scheme offers several advantages stability assurance lucid design intuitions verification algorithm conducted motion control platform shares general characteristics several advanced manufacturing systems elsevier rights reserved
fuzzy logic based modeling approach using universal soil loss equation usle along selection application appropriate coir geotextile soil erosion control attempted study fuzzy logic model developed address issues soil erosion risk constant rainfall intensity two simple efficient fuzzy logic soil erosion models developed one predicting soil erosion intensity fuzzy soil erosion model sem selecting appropriate type soil erosion control based types soil various combinations slope angle length crop cover rainfall intensity forth fuzzy model cgm two models developed way input data requirement minimum model execution considered input parameters main primary governing factors influence soil erosion intensity usle platform sem cgm compared actual field data found closely matching sem predicts erosion intensity area cgm used selection cgs erosion control application american society civil engineers
general formulation solution fractional optimal control problems focps terms caputo fractional derivatives cfds arbitrary order considered paper performance index focp considered function state control dynamic constraint expressed fractional differential equation fde arbitrary order general pseudo state space representation fde presented based focp developed numerical technique based grunwald letnikcov approximation fds used solving resulting equations numerical example presented show effectiveness formulation solution scheme
gigantic sustainable tourism project taking shape city order government abu dhabi sheikh zayed desert learning center szdlc first constructed building masterplan functions museum research centre desert environments ecological issues building owner set ambitious targets sustainability energy efficiency szdlc already certified program leed leadership energy environmental design leed platinum standard paper two parts pioneering state art architecture technology szdlc project presented firstly report basic results advanced energy modelling simulation planning phase certification method given secondly authors publish energy performance data operating solar heat driven absorption cooling system published elsevier ltd
global map drought risk elaborated sub national administrative level motivation study observation little research concerted efforts made global level provide consistent equitable drought risk management framework multiple regions population groups economic sectors drought risk assessed period based product three independent determinants hazard exposure vulnerability drought hazard derived non parametric analysis historical precipitation deficits drought exposure based non parametric aggregation gridded indicators population livestock densities crop cover water stress drought vulnerability computed arithmetic composite high level factors social economic infrastructural indicators collected national sub national levels performance evaluation proposed models underlines statistical robustness emphasizes empirical resemblance geographic patterns potential drought impacts previous results presented literature findings support idea drought risk driven exponential growth regional exposure hazard vulnerability exhibit weaker relationship geographic distribution risk values drought risk lower remote regions tundras tropical forests higher populated areas regions extensively exploited crop production livestock farming south central asia southeast south america central europe southeast united states climate change projections foresee increase drought frequency intensity regions aggravated risk global food security potential civil conflict medium long term since agricultural regions show high infrastructural vulnerability drought regional adaptation climate change may begin implementing fostering widespread use irrigation rainwater harvesting systems context reduction drought risk may also benefit diversifying regional economies different sectors activity reducing dependence gdp agriculture european commission published elsevier ltd
gluten free diet gfd reported negatively impact quality life qol coeliac disease patients gut brain axis hormones ghrelin leptin brain derived neurotrophic factor bdnf may affect qol patients undergoing gfd aims evaluate whether circulating concentrations leptin ghrelin bdnf patients different healthy subjects gfd might induce changes levels bdnf valmet polymorphism variability might affect bdnf levels serum bdnf levels related dietary docosahexaenoic acid dha neurotrophin modulator nineteen adult coeliac patients healthy controls included qol questionnaire administered serum concentrations ghrelin leptin bdnf red blood cell membrane dha levels determined enrolment year gfd bdnf valmet polymorphism analysed results questionnaire indicated decline qol gfd ghrelin leptin levels significantly different groups bdnf levels significantly lower patients gfd compared controls patients diagnosis bdnf levels correlated dha levels questionnaire total score ghrelin leptin seem associated changes qol patients undergoing dietetic treatment contrast link bdnf reduction vulnerability patients psychological distress could proposed dha representing possible intermediate
gold nanoparticle probe based assay gnpa developed ultrasensitive detection hepatitis virus hcv core antigen gnpa anti hcv core antigen polyclonal antibodies single stranded barcode signal dna labeled gold nanoparticle probe dna enzyme used degrade unbound barcode dna anti hcv core antigen monoclonal antibodies coated magnetic microparticles probe mmp hcv core antigen mmp sandwich immunocomplex formed target antigen protein added captured magnetically separated immuno complex containing single stranded barcode signal dna characterized tagman probe based real time fluorescence pcr detection limit determined hcv core antigen magnitude greater elisa coefficients variation intra assay inter assay respectively ranged improved gnpa decreased interference unbound barcode dnas may new way hcv core antigen detection published elsevier
good sleep environment essential maintain person health daily working performance create comfortable healthy sleep environments less energy use worth exploring findings based one questionnaire survey sleep environments conditioned different cooling modes reported study investigated use different cooling devices relation effect sleep human responses thermal environments air quality created different cooling modes also studied totally completed questionnaires statistically analysed results show respondents prefer use air conditioner months year relatively low temperature settings especially respondents living fifth floor better choose relatively high temperature settings reduce air conditioning intensity especially elders outdoor workers avoid cold thermal discomfort also reduce electric energy use elders outdoor workers persons living higher floor levels increase usage electrical fans natural ventilation thermal comfort maintained raised air movement perceived air quality could improve obviously introducing outdoor air would create good sleep environment ensure sleep quality
good task design improve efficiency business reduces cost helps analysis risk classification permit manager influence human organizational factors complexity socio technical systems discussion held techniques proposed embrey lees hollnagel reason rasmussen avila dealing task project subject forms control understanding complexity production systems enables development suitable tools prevent accidents mitigate consequences task performance depends cognitive organizational requirements beyond technical organizational climate transparency reporting incidents managerial profile communicate routine operating emergency indicators decision making task sufficient knowledge base team accomplish task communication tools production shift return view staff trust cooperation understanding risks causal relationship events perform task understanding work patterns resulting performance indicators control production appropriate design technology process equipment allow review man machine interface man procedure david embrey discusses hierarchical task analysis hta presents criteria risk complexity task lees presents discussion need side project machine man presenting cognitive requirements machine design machine operating requirements human knowledge rasmussen reason discuss level knowledge understanding rules skills needed perform task holnagel presents way plan task analysis goals steps commitments avila discusses technology complexity task risk environments barriers tooling pattern knowledge commitment propose procedures standards padop considering analysis critical task quantifying efforts level parallelism realization discussion acceptance level based target performance indicators measurement suggest changes exercise developed based operational control practice chemical industry sulfuric acid purification authors published elsevier
ground cover rice production system gcrps reported reduce consumption irrigation water increasing grain yield water use efficiency regions water temperature limiting factors rice production however fertilizer must applied single basal dose soil surface covered plastic film gcrps resulting excessive vegetative crop growth nitrogen deficiency reproductive stage furthermore severe drawback gcrps soil water pollution residuals polyethylene film used ground cover two year field experiment conducted using biodegradable film together treatments comparing basal application application three splits single basal fertilization urea plus manure examined uptake crop growth transplanting harvest rice grain yield yield components dynamics tillers shoot dry matter recovery efficiency compared basal application fertilizer gcrps split application basal combination urea plus manure conjunction use biodegradable film significantly increased rice grain yield number productive tillers spikelets per square meter improved crop growth rate uptake rate panicle initiation maturity significantly increased agronomic efficiency fertilizer recovery efficiency grains results highlight using biodegradable film instead standard plastic film allows split application fertilizers increases yield use efficiency well significantly reduce environmental pollution plastic film gcrps elsevier rights reserved
group buildings west china campus sichuan university atherton building biology preventive medicine lamont library harvard yenching museum whiting memorial administration building featured chinese western styles built five western churches together name private west china united university protect buildings authors tested strength materials taken buildings inspected buildings site evaluate structure historical constructions authors suggested protective measures adopted rehabilitation buildings evaluated repair effect method field vibration test test inspection analysis evaluation buildings lots information data historical constructions accumulated
group plans recently found construction management municipality santiago part official plan urbanization commune santiago scales dated enabled carry research representation studies analyzes condition modern city capital city plans valid fifty years management city urban development find origins karl brunner studies proposals draft project made possible second stay robert humeres finally developed five coming years problem approach article therefore related capacity cartography contain specific idea modern city fact thesis article official plan gives account existing city rigorously registered new one arising product transformation according indications represented double intentionality underlies point view clearly modern bias evidenced willingness understanding new comes pre existent phenomenon necessary abstraction representation achieve allow worlds cohabitate plan observation confirmed prove plan configured three types lines synthetize complexity public space
growing awareness child sexual exploitation cse united kingdom throughout world prompted human service legal policy professionals seek ways engaging young people experiencing sexual exploitation although much remains unknown regarding effective practice whether current knowledge regarding best practices young people expanded address cse paper considers principles harm reduction public health approach widely used engage adults young people help seeking behaviours considered part children rights centred approach policy practice young people experiencing cse authors children society published national children bureau john wiley sons ltd
growing body research points role social norms may play maintaining carbon intensive lifestyles soliciting changes towards sustainable ways living however despite highlighting importance pro environmental social norms literature said far less processes norms might develop present new approach conceptualising social norms focuses understanding dynamics within social interaction positioning interpersonal confrontation potential mechanism change examine normative dynamics environmentalism comparing costs interpersonally confronting climate change disregard associated confronting racism two experimental studies presented participants scenarios describing person confronting versus confronting contentious comments domain identified social costs interpersonal confrontation climate change disregard racism indicated reduced ratings perceived warmth closeness confronter study effect mediated perceived morality issue question study findings highlight wider social constructions morality around climate change impact upon social interactions ways important implications processes social ultimately environmental change elsevier ltd rights reserved
growing number studies examined immigrant paradox respect health behaviors united states however little research attention afforded study adverse childhood experiences ace neglect physical sexual abuse witnessing violence among immigrants united states present study using waves data national epidemiologic survey alcohol related conditions nesarc aims address gaps comparing forms ace first second generation immigrants native born american adults united states also examined latent structure ace among immigrants conducted analyses assess psychiatric correlates identified latent classes exception neglect prevalence ace markedly higher among native born americans second generation immigrants compared first generation immigrants four latent classes identifiedlimited adverse experience emotional physical abuse family violence global adversity latter three classes evinced greater likelihood diagnosed mood anxiety personality substance use disorder report violent non violent antisocial behavior consistent prior research examining associations immigrant paradox health outcomes results suggest first generation immigrants united states less likely experienced physical sexual abuse witness domestic violence however likely due cultural circumstances first generation immigrants likely report experiences deemed neglectful western standards
hall sensor based simple technique introduced measure wheel slip microcontroller based embedded digital system developed display wheel slip data warn operator audible visible warnings optimum range exceeds hall sensor slip measurement system validated controlled soil bin condition tar macadam surface actual field condition compared commercial radar sensor developed system simple construction mounted make model agricultural tractors entering appropriate rolling radius via computer interface field trials conducted measure wheel slip fuel consumption farm use without activation slip indicator observed amount fuel saving various agricultural operation istvs published elsevier ltd rights reserved
hallmark adaptive cognition ability modulate learning response demands posed different types tests different types materials evaluate older adults process context words sentences differently examining patterns memory errors two experiments explored younger older adults sensitivity lures recognition test following study words two types contexts among studied words compound words blackmail jailbird related conjunction lures blackbird semantic lures criminal participants engaged recognition test included old items conjunction lures semantic lures unrelated new items experiments younger older adults general pattern memory errors incorrect endorsements semantic conjunction lures following sentence study incorrect endorsements conjunction semantic lures following list study similar pattern reveals older younger adults responded constraints two different study contexts similar ways however although younger older adults showed similar levels memory performance list study context sentence study context elicited superior memory performance older participants appears though memory tasks take advantage greater expertise older adults case greater experience sentence processing reveal superior memory performance elderly
heating ventilation air conditioning hvac system multi variable strongly coupled large scale system composed several sub systems considerable research simulations experiments conducted hvac control optimization control hvac system popular issue ultimate goal paper achieve minimum energy consumption improve system efficiency multi zone variable air volume variable water volume air conditioning systems developed dynamic models hvac sub systems built adaptive directional forgetting method control strategies gearshift integral proportional integral derivative pid controller self tuning pid controller studied platform improve dynamic characteristics hvac system system performance improved system saved energy integration iterative learning control sequential quadratic programming based steady state hierarchical optimization control scheme
helicopter flight control system typical multi input multi output system strong channel coupling nonlinear characteristics paper presents explicit model predictive control empc attitude regulation tracking degree freedom dof helicopter state space representation system established according characteristics degree freedom motion multi parametric quadratic programming mpqp online computation processes explicit model predictive control controller design dof helicopter discussed controller design set point regulation tracking time varying reference signals dof helicopter presented respectively numerical study explicit model predictive control attitude regulation tracking dof helicopter conducted hardware loop experimental study explicit model predictive control dof helicopter made analyze performances empc controlled helicopter system active mass disturbance system manual interference considered comparison pid scheme numerical simulation hil experimental studies show explicit model predictive control valid satisfactory performance dof helicopter
high level concern placed storage handling transportation distribution vaccines pharmaceutical products particularly time temperature sensitive active passive cooling equipment monitoring devices important various personnel responsible executing writing procedures designing operating systems investigating problems helping prevent paramount establishing maintaining cold chain time temperature sensitive pharmaceutical products ttspps professionals must possess required competencies knowledge skills abilities effectively perform activities appropriate levels expertise complex tasks require development higher cognitive skills adequately addressed professional development opportunities based simple information delivery content acquisition paper describes two unique learning solutions one bus called wheels course online called learning developed global learning opportunities glo provide participants opportunities learn cold chain systems vaccine management rather develop high levels expertise respective fields experiential authentic learning activities interactive learning environments participants opportunities address real life situations contexts similar may face work environments develop solutions critical thinking skills apply return jobs paper delineates managerial operational vaccine management functions encompassed two unique learning environments paper also describes alignment objectives addressed wheels course learning version effective vaccine management evm criteria prescribed paper concludes example real world product developed course graduates specifically decision tree used national programmes types products valuable right often emerge learning environments based authentic learning principles designed implemented glo authors published elsevier ltd
high altitude asl integrated participatory watershed development programme implemented west khasi hills meghalaya north eastern indian himalaya aim assess refine practices integrating crop fish livestock production systems soil water conservation measures active participation local inhabitants included construction renovation ponds jalkunds micro rainwater harvesting structures bench half moon terraces impact analysis revealed million litres water harvested enhanced potato rice crop productivity respectively farmers able earn net incomes around per month community dairy units fish ponds respectively
higher kinematic pair converts rotary motion helical motion presented alternative screw joint lower kinematic pair first existence rolling transmission pair rotary helical motion conversion proven corresponding pair rolling surfaces pitch surfaces relative position defined set kinematic transmission parameters calculated examples presented method gear tooth forming pitch surfaces using boolean operations computer aided design cad program proposed finally applying methodology pair gears rotary helical transmission obtained using printer prototype presents negligible clearances backlash high reversibility well continuous gearing without interference meshing equation simple generating surface also provided
high throughput screen ligand binding domain nuclear receptor retinoic acid related orphan receptor gamma ror gamma employing thermal shift assay yielded quinoline tertiary alcohol hit optimization positions quinoline core using structure activity relationships structure based drug design methods led discovery series modulators improved ror gamma inhibitory potency inverse agonism properties elsevier ltd rights reserved
high voltage high frequency power supply ozone generation presented paper ozone generation intended used air water disinfection power stage consisting single phase full bridge inverter regulating output power current push pull inverter driver control circuit described analyzed laboratory build power supply using high voltage ferrite transformer pic microcontroller employed energize dielectric barrier discharge dbd ozone generator inverter working basis control strategy simple structure variation range working frequency order obtain optimal frequency value experimental results concerning electrical characterization water treatment using cylindrical dbd ozone generator supplied power supply given end
human health control monitor system hhcmses mobile medical application used detect continuous monitoring manage human body blood glucoses levels hhcms promises give extend life period human hhcmses testing device efficient monitor glucoses levels sensor wear anywhere human body like wrist watches sensor connects smart phones using hhcmses software connected software continuously monitor blood glucoses levels body body change glucose levels intimate smart mobile phones hhcms easily monitor indoor outdoor physical movement blood levels changing often body existing approaches uses moment generate function mgf support statistical method gathering value reviewing value survey value give interpreting variable numerical data identifying transfer function sensor mobiles paper propose robust compatible uses mason gain formula mgf process detect transfer function using linear signal flow graph sfg cyebyshev theorem markov theorem uses find desired result hhcmses
key pillar success company business ability succeed global rapidly changing labour market achieved workforce qualified skilled flexible thus clear emphasis also put staff development development achieved many ways one lifelong learning supported universities paper presents learning study materials developed academics department machine design dmd faculty mechanical engineering fme university west bohemia uwb study materials focus design projects industrial practice several projects one focuses specific machine outputs projects learning pdf files study materials contain important information designer usually comes contact example drawing documentation model calculation reports welding technology etc study materials developed primarily full time students department machine design rectify lack practical knowledge project completed became clear study materials could also applied context lifelong learning institute lifelong learning university west bohemia offers courses training companies general public courses employees tend narrowly focused area specified company public courses designed training individuals open courses periodically arranged spring autumn year train groups due narrow specialization engineers work industrial practice loss continuity education areas mechanical engineering elearning study materials comprehensive include knowledge different fields engineering new job study materials help employee study problematics starting work another field possibly even shorten company learning study materials also help large extent job interview study materials created cooperation experts industry according currently valid technical standards
like nonlinear differential equation introduced generalised bilinear equation possesses bilinear form standard bilinear equation symbolic computation nine classes rational solutions resulting like equation generated search polynomial solutions corresponding generalised bilinear equation three generalised bilinear differential operators adopted associated prime number
label free porous silicon psi based optical biosensor using antibody aptamer bioreceptor motif developed detection insulin two parallel biosensors designed optimised independently based bioreceptor bioreceptors covalently attached thermally hydrosilylated psi surface though amide coupling unreacted surface area rendered stable low fouling incorporation peg moieties insulin detection ability biosensor determined using interferometric reflectance spectroscopy using range different media without serum sensing performance compared terms response value response time limit detection lod platform order demonstrate capability best performing biosensor detect insulin real samples vitro investigation aptamer modified surface performed biosensor exposed buffer conditioned glucose stimulated human islets result showing positive response high degree selectivity towards insulin capture obtained results correlated well elisa used clinic assaying glucose stimulated insulin release donor islets anticipate type sensor applied rapid point use biosensor assess quality donor islets terms insulin production efficiency prior transplantation
large number studies conducted economic psychology cognitive sciences behavioural finances support idea economic actions result rational utility maximising behaviour seem driven factors personality traits psychological factors gender age genetic heritage context capital markets sometimes non efficient anomaly based trading strategy could used enhance returns especially case emergent markets article analyses presence seasonal affective disorder sad effect romanian stock market time span includes calm growth periods volatile periods one global financial crisis results support existence correlation number hours daylight market returns last financial crisis even effect seems change crisis
large set earthquake records highly instrumented samoa channel bridge ground system compiled made available california geological survey six seismic events data channels documenting seismic response bridge abutments adjacent ground surface special interest response one bridge piers records deck level pile cap within underlying pile foundation response pile foundation compared ground documented nearby eureka geotechnical downhole array paper records strongest date ferndale earthquake pga along available low amplitude events employed evaluate ground pile foundation overall bridge seismic response spatial variation recorded motions examined linear nonlinear response ground bridge assessed using system identification techniques strong shaking phase ferndale earthquake clear significant stiffness reduction observed column well foundation instrumented pier
liquid metal electric motor including pair concentric ring electrodes permanent magnet electrolyte solution demonstrated liquid metal galinstan sphere along naoh solution stimulated rotate centrifugally around central electrode rotating speed increases voltage naoh solution serves rapidly remove oxide liquid metal surface reduce motion friction provide impetus liquid metal mass liquid metal increased form kidney like body rotating speed appears controllable effect electrolytic action naoh solution becomes weak range mass liquid metal increased form circular ring shaped body ideal voltage range controlling rotating motion liquid metal metal fluid rotates speed even extremely low voltage liquid metal electric motor established find important applications chip cooling liquid metal pumps material mixing soft machine realization etc
literature review identified absence robust framework guides development streamlined valid multiple linear regression mlr predictive models construction engineering applications reliable mlr model requires appropriate set input variables satisfy underlying assumptions best linear unbiased estimators blue research analytical framework proposed developing mlr based predictive models selecting input variables based modified stepwise approach verifying blue assumptions validating prediction performance regression model resulting mlr model contains relevant input variables also fulfilling blue assumptions utilizing statistical inference techniques mlr model also produces reliable range estimates around point value prediction according particular confidence level illustrate application procedure proposed framework data set intended workability control ready mixed concrete university california irvine uci machine learning repository used practical case study based real world bridge construction project provided demonstrate application proposed methodology modeling precast span installation cycle time american society civil engineers
literature review relating problems connected evaluation fatigue strength materials carried concerning appropriate probabilistic models found fatigue strength could described following distributions exponential weibull normal gumbel ferecht reyleight gamma log normal however modeling problems fatigue strength durability textile materials probabilistic models based weibull theory based log normal distribution seem useful considerations presented also proved many factors mainly kind material used length fibers assembly evenness thickness yarn system spinning influenced fatigue strength linear textile articles
load estimation algorithm based means cluster analysis developed algorithm applies cluster centres previously clustered load profiles distance functions estimate missing future measurements canberra manhattan euclidean pearson correlation distances investigated several case studies implemented using daily segmented load profiles aggregated smart meters segmented profiles cover time window less equal simulation results show canberra distance outperforms distance functions results also show segmented cluster centres produce accurate load estimates daily cluster centres higher accuracy estimates obtained cluster centres range developed load estimation algorithm integrated state estimation network operational tools enable better monitoring control distribution networks authors published elsevier ltd
longitudinal harvested rainwater quality monitoring study undertaken sites within selangor malaysia period months overall harvested rainwater good quality falling within malaysian recreational water quality class standards exceptions ammonia phosphates total coliforms large number samples tested positive escherichia coli total coliforms chromobacterium violaceum showing disinfection harvested rainwater mandatory prior reuse harvested rainwater samples exceeded lead limits malaysian drinking water standards showing consuming rainwater without additional treatment may pose health risk mixing harvested rainwater groundwater resulted higher phosphates total coliforms rainwater collected wet seasons higher concentrations suspended solids turbidity escherichia coli dry seasons due antecedent dry period last least principal component analysis positive matrix factorisation conducted samples apportion pollutant sources harvested rainwater principal components identified namely industrial dust steel roadside dust faeces organic decay fertilisers plumbing results principal component analysis positive matrix factorisation agreement although latter identified mains water top additional factor responsible dissolved solids techniques effective apportioning pollutant sources harvested rainwater show rainwater harvesting system designed carefully reduce contributions steel plumbing organic decay bird faeces industrial dust roadside dust elsevier ltd rights reserved
longstanding debate exists population policy relationship modern contraception abortion although theory predicts substitutes empirical evidence difficult interpret required large scale intervention alters supply full price one importantly isolation reproductive health programs often bundle primary health care family planning instances abortion services article study nepal legalization abortion provision subsequent expansion abortion services unusual rapidly implemented policy meeting requirements using four waves rich individual level data representative fertile age nepalese women find robust evidence substitution modern contraception abortion finding important implications public policy foreign aid suggesting effective strategy reducing expensive potentially unsafe abortions may expand supply modern contraceptives
long term goal field determine sequence pathological events ultimately lead cognitive decline dementia study first assessed patterns brain tau tangle accumulation measured positron emission tomography tracer associated well established alzheimer disease factors cohort including cognitively healthy elderly individuals individuals early symptomatic stages alzheimer disease explored highly associated patterns greater binding increased annualized change cortical amyloid beta plaques measured florbetapir positron emission tomography binding antecedent positron emission tomography scans extent multimodal pattern associations explained variance cognitive performance clinical outcome measures independently jointly found positron emission tomography retention differentially associated age cross sectional florbetapir positron emission tomography retention years education gender apoe genotype increased annualized change florbetapir retention antecedent positron emission tomography scans parieto temporal precuneus brain regions associated greater pet retention prominently inferior temporal inferior parietal regions full cohort florbetapir positive negative associated variability iii positron emission tomography retention pattern significantly explained variance cognitive performance clinical outcome measures independent associated antecedent increased annualized change florbetapir positron emission tomography retention findings agreement pathology literature suggests tau tangles amyloid beta plaques correlate cognition clinical symptoms furthermore non local associations linking increased amyloid beta accumulation rates increased tau deposition great interest support idea amyloid beta pathology might remote effects disease pathology spread potentially via brain intrinsic connectivity networks
low cost fast reliable microcontroller based protection scheme using wavelet transform artificial neural network proposed effectiveness evaluated real time proposed scheme based hardware simulation approach performs functions transmission line protection fault detection classification fault zone section identification location estimation fault detection classification zone identification algorithms use fundamental frequency current component estimate fault index fault location estimation module uses wavelet transform coefficients hybridization parallel artificial neural network structure hardware implementation bit atmega microcontroller used interfaced simulated power system model using integrated development environment ide scheme tested power system model three phase double circuit line source ends laboratory tests performed real time fault cases including evolving faults varying fault resistance fault inception angle fault distance direction power flow angle magnitude tests confirm suitability reliability proposed scheme even current transformer saturation implementation proposed approach low cost microcontroller lesser execution time makes prototype ideal implementation digital platform digital relay thus leading financial viability sustainability protection scheme elsevier ltd rights reserved
low pass complex band pass cbp reconfigurable analog baseband circuit software defined radio sdr receivers presented achieves mhz bandwidth mhz cbp bandwidth gain range step nulling resistor miller feed forward nrmff differential mode compensation passive left half plane lhp zero common mode compensation quasi floating gate qfg technique proposed improve high frequency performance driving capability embedded fully differential operational amplifier amp analog baseband circuit implemented cmos achieves iip ipdb iip consuming power supply chip area elsevier ltd rights reserved
low power analog signal processing presented low power heart rhythm analysis asic features identical independent intra ecg readout channels equipping analog qrs feature extractor low power consumption fast diagnosis fatal case level digitized sine wave synthesizer together synchronous readout circuit measure bio impedance range omega omega rms resolution higher accuracy proposed asic consumes highly integrated solution offering functionality acquiring multiple high quality intra cardiac signals requiring limited numbers external passives
low power asic signal processor vestibular prosthesis reported fabricated cmos technology designed interface implanted inertial sensors digitally assisted analog signal processor operates extensively cmos subthreshold region operation asic encodes head motion signals captured inertial sensors electrical pulses ultimately targeted vivo stimulation vestibular nerve fibers achieve asic implements coordinate system transformation correct misalignment natural sensors implanted inertial sensors also mimics frequency response characteristics frequency encoding mappings angular linear head motions observed peripheral sense organs semicircular canals otolith overall design occupies area consumes supplied
low quiescent high performance class headphone amplifier presented effect input referred offset quiescent power audio power amplifier apa drives small resistive load described analyzed digitally assisted offset calibration based apa topology together improved frequency compensation proposed permits use low quiescent power small compensation capacitance implemented cmos technology amplifier occupies area consumes supplies load omega gain bandwidth product mhz using total compensation capacitance performance metrics measured total harmonic distortion thd signal noise ratio power supply rejection ratio psrr psrr deliver peak power vpp swing load yielding best figure merit fom peak load power quiescent power best fom peak load power quiescent power thd respect reported representative works
low voltage bandgap reference implemented cmos process designed bandgap reference circuit optimized adjusting ratio resistors reducing working voltage operational amplifier achieves performance temperature coefficient ppm degrees range similar degrees works voltage simulated power supply rejection ratio line regulation range
lumped mass thermo mechanical model dynamics damper filled magnetorheological fluid described analyzed numerically simulated model includes friction temperature effects consists differential inclusion piston displacements coupled energy balance equation temperature fluid viscosity assumed function temperature electrical current practice may used control variable numerical simulations system behavior presented particular simulations initial impact show subsequent oscillations effectively damped elsevier inc rights reserved
magnetizer design methodology takes account systematic errors variation flux density component magnetic field proposed effect sample diameter effective length yoke yoke depth analysed experimental results showed reduction large magnetizer shielding reducing yoke depth respectively comparison unshielded compact magnetizer also dependent magnetic loading furthermore magnetic contributions dominated effectiveness shielding reducing yoke depth decreased respectively achieve high flux densities magnetizers designed compact sample diameter narrow airgaps reduction size increases leakage field sample level magnitude applied field affects measurement magnetic field two coil sizes sensitivity difference used show measured independent coil size depends leakage field measured core loss difference pulsating rotating fields
magnetorheological elastomer mre smart material reversible variable modulus magnetic field natural rubber better physical properties silicone matrices used matrix fabrication mres used study carbonyl iron powder cip rapid magnetic reaction selected magnetic material generate magnetic field dependent modulus mres mre specimens cured anisotropic mold could used induce uniaxial magnetic field via permanent magnets control orientation cip shear modulus mres evaluated magnetic field induced using magnetic flux generator mfg use conventional evaluation system determine magnetic field dependent shear modulus mres difficult evaluation system based single degree freedom vibration electromagnetics included mfg device generates magnetic field via variable induced current designed electromagnetic finite element method fem analysis design experiments doe techniques employed optimize magnetic flux density generated mfg optimized system verified range determine magnetic flux density generated mfg order use magnetic circuit analysis identify existence magnetic saturation variation shear modulus observed increasing cip volume fraction induced current experimental results revealed maximum variation shear modulus vol cip induced current results appropriate cip volume fraction induced current design procedure mfg proposed guidelines applications mres based natural rubber
means digitally generate partially coherent beam orbital angular momentum presented approach based encoding randomness broadband light passing spiral phase plate spatial light modulator illustrate technique generating partially coherent beams orbital angular momentum content different coherence lengths moving optical elements study cross correlation spectra yields good agreement theory
mechanomyogram mmg measured displacement sensor displacement mmg provide better estimation longitudinal muscle stiffness measured acceleration sensor acceleration mmg displacement mmg provide transverse muscle stiffness propose method estimate longitudinal transverse muscle stiffness velocity mmg using system identification technique aims study show advantages proposed method velocity mmg measured using capacitor microphone differential circuit mmg evoked electrical stimulation tibialis anterior muscle measured five times seven healthy young male volunteers evoked mmg system identified using singular value decomposition method approximated fourth order model provides two undamped natural frequencies corresponding longitudinal transverse muscle stiffness fluctuation undamped natural frequencies estimated velocity mmg significantly smaller acceleration mmg significant difference fluctuations undamped natural frequencies estimated velocity mmg displacement mmg proposed method using velocity mmg thus advantageous muscle stiffness estimation elsevier ltd rights reserved
method developed reducing power inverter electrical circuit fourth order electrical network second order reduction based assumption output inverter voltage practically sine wave shape normalized form guarantees novelty versatility investigation one hand independency relation concrete inverter parameters like output power supplying voltage operating frequency whole power network fourth order first time two sub circuits suggested outlined output load sub circuit inverter commutating sub circuit sub circuits second order define parameters endmost inverter circuit order consequently mode operation parameters power inverter transformation possible owing newly found fact frequency dependencies output load sub circuit separated dependencies describe structural relationships two sub circuits results conversion course accurate resonant frequencies sub circuits operating frequency differ substantially suggested approach useful order obtain simplified engineer method precise fast design large class static power converters applicable electronic technology like induction heating melting
method characterize small antennas actual operating conditions presented proposed procedure based radar cross section rcs measurement technique using backscattering modulation theoretical description measurement setup based signal flow graph representation presented experimental validation includes measurement one two port antennas well measurement small integrated antenna results show effect environment antenna impedance adequately measured proposed system
methodology based artificial neural networks ann analog ensemble anen presented generate deterministic probabilistic forecasts power generated photovoltaic power plants using input numerical weather prediction model computed astronomical variables ann anen used individually combination generate forecasts three solar power plants located italy computational scalability proposed solution tested using synthetic data simulating power stations national center atmospheric research ncar yellowstone supercomputer employed test parallel implementation proposed solution ranging one node cores nodes cores results show combined anen ann solution yields best results proposed solution well suited massive scale computation published elsevier ltd
methodology optimum sizing different components rotor diameter electrical generator rating battery capacity standalone wind battery system proposed paper basis time series simulation system performance along different design constraints entire set feasible design options also known design space identified rotor diameter rated power diagram design space standalone wind battery system identifies entire envelope within feasible system may designed optimum configuration standalone system identified basis minimum cost energy kwh observed cost energy sensitive magnitude average demand wind regime sensitivity capital cost minimum cost energy also studied elsevier ltd rights reserved
methodology analysis wear internal combustion engine valves proposed result combined use numerical experimental techniques numerical solutions obtained using specialized finite element method mortar contact algorithm used model flexible flexible contact along adhesive wear law experimental results obtained wear testing rig specifically designed evaluate wear parameters valve operating conditions good agreement found experimental worn profiles numerical computations wear contact surfaces elsevier ltd rights reserved
model accurately predicts time admission length stay los hospitalized patients could effective tool healthcare providers could enable early interventions prevent complications enabling efficient utilization manpower facilities hospitals study apply regression tree cubist model predicting los based static inputs values known time admission change patient hospital stay model trained validated identified administrative data veterans health administration vha hospitals pittsburgh chose use cubist model produced accurate predictions alternative techniques addition tree models enable examine classification rules learned data order better understand factors correlated hospital los cubist recursively partitions data set estimates linear regressions partition error level differs different partitions possible deduce characteristics patients whose los accurately predicted admission characteristics patients los estimate point time highly uncertain example model indicates prediction error greater patients admissions recent past longer previous hospital stays approach suggests mapping cases higher dimensional space using radial basis function rbf kernel helps separate level cubist error using support vector machine svm elsevier ltd rights reserved
modified gaussian current density put forward used simulate dynamic process azb magnesium alloy double electrode gas metal arc welding gmaw droplet transfer process droplet transfer azb magnesium alloy gmaw simulated using fluent software influence different bypass welding currents investigated constant total current simulated results revealed bypass current process globular transfer type droplet transfer bypass current projected transfer type droplet transfer bypass current spray transfer type critical current decreased spray transfer would occur lower current level gmaw process bypass current increased shape droplet changed oval round transition frequency droplet increased stepwise fashion confirm accuracy simulated results welding experiments performed image processing method used obtain droplet size simulated experimental results found good agreement
modified version original derived relational intrusions following training paradigm drift guinther dougher journal experimental analysis behavior used attempt engineer contextually controlled semantic false memories participants completed contextually controlled interrelated conditional discrimination training procedure match sample without tests symmetry transitivity study list words nominally assigned participate functional equivalence class set non study words context different set non study words different context study list words presented contexts subjects free recall memory testing subsequent transfer study list words remembering function non study words false recall found partially dependent upon context free recall test administered thus demonstrating partial contextual control semantic false memory
moisturizing cream mixed steroid ointment frequently prescribed patients suffering atopic dermatitis however concern mixing operation causes destabilization present study performed investigate stability preparations closely using magnetic resonance imaging sample preparations five commercial moisturizing creams popular japan mixed ointment base white petrolatum volume ratio mixed preparations stored degrees accelerate destabilization processes subsequently phase separations induced storage test monitored using using advanced technologies including spin spin relaxation time mapping spectroscopy successfully characterized phase separation behavior test samples samples phase separations developed bleeding liquid oil components sample consisting oil water type cream urepearl cream distinct phase separation mode observed initiated aqueous component separating bottom part sample resultant phase separation distinct among test samples investigate phase separation quantitatively objectively conducted histogram analysis acquired maps water oil type creams found much stable mixing ointment base oil water type creams finding strongly supported validity mixing operation traditionally conducted pharmacies
profound investigation responses activity levels following pulmonary rehabilitation patients copd needed aimed describe groups patients copd according patterns change physical activity sedentary behaviour following patients copd male mean age median fev pred completed comprehensive programme triaxial accelerometer used assess time sedentary behaviour light activities moderate vigorous physical activity mvpa additionally exercise capacity quality life symptoms anxiety depression assessed six groups different patterns change physical activity sedentary behaviour identified two prevalent patterns represented good responders increase physical activity reduction sedentary behaviour poor responders decrease physical activity increase sedentary behaviour good responders greater improvements six minute walk distance mwd symptoms depression poor responders strong correlation found changes sedentary behaviour changes light activities changes mwd correlated fairly changes sedentary behaviour light activities mvpa different patterns change activity levels following found patients copd focusing light physical activities might potential strategy make patients less sedentary achieved prior least parallel improvements functional capacity seem necessary elsevier ltd rights reserved
multimodal damping strategy implemented coupling beam analogue electrical network network comes direct electromechanical analogy applied transverse lattice point masses represents discrete model beam mechanical electrical structures connected together array piezoelectric patches discrete semi continuous model proposed describe piezoelectric coupling based transfer matrix formulation consider finite number patches shown simple coupling condition gives network approximates modal properties beam multimodal tuned mass effect obtained wide band damping introduced choosing suitable positioning resistors network strategy models experimentally validated coupling free free beam completely passive network multimodal vibration reduction observed proves efficiency control solution potential term practical implementation
multiscale approach pursued develop modified shear lag model capturing size scale effects electrostatic potential generated zinc oxide zno nanowire nanocomposite electrical generator nceg size scale effect elastic modulus zno nws captured using core surface model closed form governing equations derived considering linear elasticity axisymmetric problem cylindrical coordinate system two different configurations based parallel series connecting ncegs application nems mems devices also studied parametric studies performed sample cases demonstrate application developed model shown aspect ratio diameter nws crucial controlling parameters determining performance nanocomposite electrical generators numerical results disclose optimum aspect ratio specific diameter also shown despite symmetry loading respect mid plane normal axis electric potential symmetric elsevier ltd rights reserved
multistage graph center problem computer science many coordination consistency problems convert multistage graph problem obtained fitness function coding vertex multistage graph designed genetic algorithm solving multistage graph problem experiment results show algorithm effective feasible
multi tap microwave photonic filter mpf center frequency tuned single parameter proposed demonstrated based polarization modulation simply adjusting amplitude sawtooth wave signal polarization modulator mpf tuned shape free spectral range fsr unchanged proposed system advantages terms simple operation fast tunability large bandwidth
multi view content generation method three dimensional display without depth reversed area demonstrated viewing zone periodicity autostereoscopic display utilized eliminate depth reversal adjusting light field alignment light field conditions multi view sequence satisfies form depth reversal free sequence given detailed processes converting multi view sequence depth reversal free sequence presented experimental results show depth reversed area well eliminated smooth motion parallax achieved viewer moves front display within degrees viewing angle number presented perspectives times viewpoint number autostereoscopic display help viewing zones integration
networking laboratory essential tool teaching communications engineering however effort cost invested creating networking laboratory physical equipment significantly high especially students work realistic scenarios substituting physical networking devices virtualized ones virtualization technologies may contribute simplify laboratory management tasks allow creation affordable complex network scenarios way students work experiment realistic network scenarios learning experience greatly improved paper detailed description virtualization based networking laboratory model evolved last years authors experience teaching computer networking provided laboratory model implemented using virtual networks linux vnx open source tool specifically designed developed define build deploy manage networking scenarios taking full advantage virtualization supporting hybrid virtual physical scenarios heterogeneous operating systems features vnx tool illustrated example complex network scenario used students described survey based assessment usage experience vnx included paper showing validity efficacy proposed laboratory model vnx tool teaching computer networking laboratory assignments
new approach implement smart ecosystem freight transportation proposed aimed improve efficiency safety security sustainability including ambient intelligence containers infrastructure supports involves technological well organizational logistic improvements achieve goal approach developed project named ecotransit funded spanish mineco involving university seville public university navarre proposal represents qualitative step beyond existing projects innovation key areas logistics critical enabling technologies like microelectronics icts
new design metamaterial absorber triple band band range proposed radar cross section reduction stealth technology proposed metamaterial absorber advantage ease design three layered structure designed modified ring resonators printed dielectric material metal ground proper tuning geometry parameters structure triple band metamaterial absorber achieved adjusted match effective impedance metamaterial absorber free space hence wave transmission minimized reflection absorption rate maximized bands resonant frequency bands ghz ghz ghz absorption rates respectively bandwidths measured triple band ghz ghz ghz total miniaturized metamaterial absorber unit cell size simulation results show proposed absorber triple band high absorption rate well suited radar cross section reduction stealth technology
new digital predictive control strategy single phase boost power factor correction pfc converter presented paper reduce harmonic distortion improve dynamic response based converter circuit structure values output voltage inductor current next switching cycle predicted advance steady state algorithm dynamic state algorithm implemented respectively duty cycle calculated via predicted output voltage inductor current values steady process optimized duty cycle predicted dynamic process improve characters pfc converter single phase boost pfc converter proposed digital predictive control strategy implemented via field programmable gate array fpga experimental results indicate proposed digital control strategy improve power factor dynamic response pfc converter simultaneously
new facultative anaerobic exoelectrogenic strain belonging citrobacter freundii isolated strain produce current densities using citrate acetate carbon source three electrode configuration electricity generation performance also analyzed dual chamber mfc system reaching maximum power density addition acetate citrate carbon sources pyruvate formate acetate citrate fumarate could also utilized produce current strain data supports presence electroacfive type cytochromes freundii grown ito electrodes linking spectroscopy electrochemistry situ since facultative strains possess many desirable properties compared anaerobic strains strain represents promising exoelectrogenic species engineering biological catalysts microbial electrochemistry
new gear set consisting planar noncircular gear specific face gear called undulating face gear presented able transmit varying angular velocity based kinematics planar noncircular pinion rack formation mechanism pitch curves undulating face gear given continuous transmission condition gear set discussed tooth surfaces undulating face gear enveloped teeth shaper cutter pitch circle rolls pitch curve undulating face gear without sliding according spatial meshing theory mathematical model face gear tooth surface built phenomenon tooth undercutting tip cutting face gear investigated three dimensional machine design software obtain minimum inner radius maximum outer radius furthermore computer program developed calculate data face gear tooth surface motion simulation gear set without undercutting tip cutting made able illustrate validity correctness design theory elsevier ltd rights reserved
new vitro model based electrical resistance properties skin barrier established laboratory model utilises tape stripping procedure dermatomed pig skin removes specific proportion stratum corneum mimicking impaired barrier function observed humans damaged skin skin penetration distribution chemicals differing physicochemical properties namely benzoic acid aminophenol caffeine sucrose assessed model although skin penetration differed chemical compromising skin alter shape time course profile although absorption receptor fluid higher chemical systemic exposure receptor fluid epidermis dermis marginally higher compromised skin following exposure fast penetrant benzoic acid slow penetrant sucrose systemically available dose aminophenol increased greater extent absorption caffeine double compromised skin suggesting molecular weight log determinants assessing systemic exposure conditions although investigations required vitro model may useful prediction dermal route exposure conditions skin barrier impaired elsevier ltd rights reserved
new intelligent hybrid structure used online tuning pid controller proposed paper structure based two adaptive neural networks built chebyshev orthogonal polynomials first substructure network regular orthogonal neural network implemented artificial endocrine factor oenn form environmental stimuli weights used approximation control signals processing system deviation disturbance signals introduced form environmental stimuli output values oenn used calculate artificial environmental stimuli aes represent required adaptation measure second network orthogonal endocrine adaptive neuro fuzzy inference system oeanfis oeanfis used process control output error signals system generate adjustable values proportional derivative integral parameters used online tuning pid controller developed structure experimentally tested laboratory model crane system terms analysing tracking performances deviation signals error signals payload oenn oeanfis performances compared traditional pid intelligent pid type controllers tracking performance comparisons transient steady state period showed proposed adaptive controller possesses performances within range tested controllers main contribution oenn oeanfis structure significant minimization deviation signals compared controllers recommended exploit dealing highly nonlinear system operates presence undesirable disturbances elsevier ltd rights reserved
new iridoid glycoside beta xylopyranoside shanzhiside methyl ester along six known compounds shanzhiside methyl ester lamalbid geniposidic acid theveside verbascoside arenarioside isolated roots lantana montevidensis structures compounds determined nmr spectroscopic data analysis hresims electronic circular dichorism uplc method total extract chloroformic aqueous fractions together isolated compounds tested antimicrobial antiprotozoal antiplasmodial anti inflammatory monoamine oxidase inhibition cell viability activities addition free radical scavenging activity using diphenyl picrylhydrazyl dpph assay phenylpropanoid compounds resulted potent antioxidant activity total methanolic extract together aqueous fraction showed decrease reactive oxidative stress respectively chloroformic fraction together total methanolic extract showed decrease inos values respectively compounds showed inhibition reactive oxidative stress values respectively fractions demonstrated measurable inhibition mcf breast cancer cell growth value compounds showed mild monoamine oxidase inhibition none tested compounds showed antimicrobial antiplasmodial antiprotozoal activity
new large dynamic range variable gain amplifier vga improved linearity presented traditional cascade vga disadvantages gain mismatch sub stages difficulty employing mismatch cancelation suppression algorithms paper switch arrays used make sub stages called gain cells coarse tuning stage cts work independently therefore prevent integral operation gain errors second order mismatch shaping dem applied conveniently cts shown useful design technique improving linearity performance cascade vga second order mismatch shaping dem integrated ghz receiver chip fabricated cmos technology supply voltage measurement results showed gain errors significantly reduced second order mismatch shaping dem respect traditionally thermometric decoding temperature range degrees copyright john wiley sons ltd
new lightning shielding failure evaluation method based electro geometric method aided graphics technology introduced approach based collection surface method shielding devices protected equipment equally considered targets lightning strikes generating collection surfaces collection surfaces projected bitmap identified colors represent protected unprotected areas respectively integral performed amplitude stroke current weighted probability distribution amplitude account dependency shape size unprotected surface stroke current using collection surfaces equipment instead unprotected area empty areas equipment protected eliminated contributing failure analysis technique applies structures substations shape use different striking distances horizontal vertical objects example substation described ieee standard used demonstrate usage technique elsevier rights reserved
new look description phenomenon electromagnetic wave radiation phase transition quasi static field state near zone field running wave far zone suggested demonstrated boundary transition called causal surface sufficiently localized position causal surface depends chosen radiation frequency skin layer media strong absorption formed boundary causal surface used depth sensing media
new method reconfigure tune program antenna presented validated fabricated proof concept prototype method relies changing electrical properties smart material vanadium dioxide across solid solid phase transition phase change material induced thermally developed device monolithically integrated based antenna changes resonant frequency demand details challenges related design fabrication integration thin films antennas well measurement setup discussed measurement results match well theory simulations results unveil new technique reconfiguring antennas suggest studies improvements could lead exciting results make vanadium dioxide thin films alternate solution multi functional antennas work first prototype implement new reconfiguration mechanism antennas gigahertz range present results metal insulator phase transition
new model power assisted bicycle designed set tested main innovative solutions pedelec prototype described present paper electric motor position new mechanical transmission low cost measurement system driving torque special test rig differently common approach electric motor located one three hubs bicycle idea pedelec prototype consists electrical motor central position means bevel gear transmits torque central hub innovative solution represented motion transmission motor pedal shaft achieved two different gearboxes first one planetary gearbox second one simple bevel gear pedelec prototype contains also new low cost measurement system driving torque based strain gauge load cell located one side rear wheel hub frame moreover commercial cycling simulator suitably modified order properly install different sensors measurement performance pedelec test rig able reproduce aforethought route paths acquired road tests measure performance bike terms instantaneous power speed experimental test rig simulate resistant torque predetermined track aims test optimize control strategy available electronic control unit authors also conducted environmental analysis developed pedelec particular comparing bike thermal moped terms environmental impact authors published elsevier ltd open access article license
new multi level markov chain monte carlo algorithm approximate bayesian computation abc subsim recently appeared exploits subset simulation method efficient rare event simulation abc subsim adaptively creates nested decreasing sequence data approximating regions output space correspond increasingly closer approximations observed output vector output space level multiple samples model parameter vector generated component wise metropolis algorithm predicted output corresponding parameter value falls current data approximating region theoretically continued limit sequence data approximating regions would converge observed output vector approximate posterior distributions conditional data approximation region would become exact practically feasible paper study performance abc subsim algorithm bayesian updating parameters dynamical systems using general hierarchical state space model note abc methodology gives approximate posterior distribution actually corresponds exact posterior uniformly distributed combined measurement modeling error added also note abc algorithms problem learning uncertain error variances stochastic state space model treat nuisance parameters analytically integrate posterior distribution addition statistical efficiency original abc subsim algorithm improved developing novel strategy regulate proposal variance component wise metropolis algorithm level demonstrate self regulated abc subsim well suited bayesian system identification first applying successfully model updating two degree freedom linear structure three cases globally locally unidentifiable model classes model updating two degree freedom nonlinear structure duffing nonlinearities interstory force deflection relationship elsevier ltd rights reserved
new nonlinear dimensionality reduction method called kernel global local preserving projections kglpp developed applied fault detection kglpp advantage preserving global local data structures simultaneously kernel principal component analysis kpca preserves global euclidean structure data kernel locality preserving projections klpp preserves local neighborhood structure data unified kglpp framework kpca klpp easily derived kglpp choosing particular values parameters result kglpp powerful kpca klpp capturing useful data characteristics kglpp based monitoring method proposed nonlinear processes spe statistics constructed feature space fault detection case studies nonlinear system tennessee eastman process demonstrate kglpp based method significantly outperforms kpca klpp glpp based methods terms higher fault detection rates better fault sensitivity elsevier ltd rights reserved
new pulsed flow design hose based solar collector presented uses long hose connected district grid water way basic hose design contrary last exit connected directly consumption instead hot water flow controlled thermostat purges hose insulated tank every time reaches desired temperature water pond collector works close maximum efficiency along day minimizes nocturnal cooling effect improving noticeably performance original hose design demonstrated thermal modeling new pulsed flow design could satisfy domestic demand sanitary hot water even high latitude locations furthermore performance could noticeably improved adding smart microcontroller economic analysis shows design could highly competitive applied large hot water demands relatively good single family demands elsevier ltd rights reserved
new randomized algorithm suggested extracting static output stabilizing feedbacks approximately minimal norm lti systems algorithm two similar stages first one feasibility problem solved second one optimization problem solved formulation unified feasibility optimization problems well continuous time discrete time systems method demonstrated applying hard conjectured hard problem minimal gain static output stabilizing feedback hard conjectured hard problem regional pole placement via static output feedback non convex unconnected regions proof convergence probability captures two rounds algorithm given complexity analysis provided mild assumptions elsevier ltd rights reserved
new sandwich structure core made thin walled semi ellipsoidal shell designed column cell sandwich composite prepared pre panel preparation process series quasi static axial compression experiments carried thin walled semi ellipsoidal shell compression deformation yield behavior thin wall semi ellipsoidal shells different materials diameters wall thicknesses studied means ansys dyna finite element simulation experiment effect filling mode epoxy resin mechanical properties column cell sandwich composites studied results show deformation process thin spherical shell divided local flattening axisymmetric depression non axisymmetric depression compaction stage wall thickness increases deformation mode changes polygon ring deformation process become three stages small diameter requires larger force conditions compression displacement diameter increases critical displacement flipping asymmetric buckling increases epoxy filled spherical shell sample specific compression performance better filled outer shell better unfilled epoxy resin elsevier rights reserved
new slicing algorithm uses multiple sets cutting planes automatically determine parting curves three dimensional parts proposed algorithm one set cutting planes used generate slicing profiles two others used determine intersection points inner outer loops parting curves algorithm provides highly effective solution handling complicated models contain free form surfaces features algorithm highlighted three case studies using tessellated geometry stl file format input resultant parting curves overcome many problems inherent current methods used various downstream computer aided design systems three dimensional mold design
new solid phase extraction mode developed separation flavones complex interference system experiment rhein anchored magnetic chitosan microparticles prepared facilely without removal template molecule used sorbents extraction target analytes completion extraction process feo particles acted carrier retrieve rhein functionalized magnetic chitosan microparticles rmcmps sample solution rmcmps showed excellent selective adsorption capacity isoflavones result suggested method useful fast determination quantification isoflavones soymilk rmcmps characterized scanning electron microscope sem ray diffraction xrd fourier transforms infrared spectrometer ftir elsevier ltd rights reserved
new sub space max monomial modeling scheme cmos transistors sub micron technologies proposed improve modeling accuracy major electrical parameters cmos transistors sub space design space modeled max monomials approach demonstrated better accuracy sub micron technologies singlespace models sub space modeling based geometric programming power optimization successfully applied three different amps technology hspice simulation results show sub space modeling based optimization allow efficient accurate analog design computational effort managed acceptable level searching sub spaces transistors using practical constraints efficient scheme dealing non convex constraint inherent kirchhoff voltage law suggested paper using scheme nonconvex constraint posynomial equality relaxed convex constraint without affecting result
new voltage mode single input single output circuit realizing proportional integral derivative controller proposed study proposed pid controller employs canonical number grounded passive components without requiring critical passive component matching conditions cancellation constraints therefore easily implemented integrated circuit process also uses three plus type differential difference current conveyors high input low output impedances thus easily cascaded configurations proportional integral derivative parameters proposed pid controller easily adjusted via resistors fix valued capacitors fabrication number analyses spice program experimental test result included demonstrate performance proposed pid controller
non destructive methodology developed automatically detect quantify bruise volumes equatorial region apples using ray images grey level threshold values calculated segment bruises jonagold joly red kanzi apple fruit using multi level otsu threshold method comparisons made based bruise volume estimates bruise volume estimates based destructive measurements combination simple geometric assumptions visualisation bruises showed bruises resulting pendulum impact spherical impactor highly irregularly shaped implies bruise volume estimations based simple geometric assumptions deliver accurate results elsevier rights reserved
non invasive automatic control method based real time virtual reality reinforcement learning reported modulate insects flight behaviour online configurable led display system proposed present visual stimulus within ultra low latency state action reward state action sarsa coupled sequential means clustering applied generate optimal control sequence automatically ensure satisfactory control performance evaluating control results bumblebees shows proposed method achieves modulate abdominal waving pattern quickly less six steps small deviation
nonlinear schrodinger equation self consistent sources used describe interaction high frequency electrostatic wave ion acoustic wave two component homogeneous plasmas paper breather rogue waves solutions system investigated via darboux transformation spatially temporally periodic breathers found cubic nonlinearity coefficient background amplitude varied propagating trajectories breather changed interaction two breathers also studied shows wave numbers close two breathers partially coalesced first second third order rogue waves present certain lumps valleys around center temporal spatial distribution peak heights ion acoustic waves three times background however high frequency electrostatic waves values around centers less background intensity
novel application coal gangue inexpensive adsorbents considered study structural surface properties natural modified gangue studied via nitrdgen adsorption four types samples studied natural modified hno calcined degrees degrees specific surface area porosity samples determined using various methods raw material mainly mesoporous relatively small specific surface area chemical modification enlarged total pore volume specific surface area calcination degrees enlarged slightly pore volume lowered specific surface area cause significant changes structural properties calcination degrees resulted significant increase pore volume decrease specific surface area results suggest coal gangue studied could used inexpensive adsorbent industrial wastewater pretreatment elsevier ltd rights reserved
novel depth defocus dfd measurement system presented extension measurement range performed using emergent technology based liquid lenses suitable set different focal lengths obtained properly changing liquid lens supply voltage provides multiple camera settings without duplicating system elements using moving parts simple compact setup single camera illuminator coaxial assembly obtained measurement based active dfd technique using modulation measurement profilometry estimation contrast image point function depth range two different measurement methods proposed based combination multiple contrast curves derived specific focal length first method intensity contrast method depth information recovered directly contrast curves whereas second differential contrast method depth measured using contrast curve pairs obtained measurement sigma depth range intensity contrast method total range sigma depth range differential contrast method total range thus intensity contrast method within state art dfd systems whereas differential contrast method allows sigma almost equal remarkable extension depth range
novel dual halbach array proposed paper increase output performance tubular linear machines magnetic field distribution three dimensional space formulated bessel functions analytically following modeling force output linear machines three phase windings carried based lorentz force law formula component force ripple separated analytical expression total force found multi phase tubular linear machines force output force ripple closely related instantaneous position mover also starting position therefore force output linear machine formulated three typical starting positions function mover positions derived models simulated respect mover motion also validated numerical results finite element calculation study shows appropriate starting position mover helps improve output performance tubular linear machines proposed analytical force model also employed analyze influence structure parameters force output linear machines similar structures
novel hybrid system composed photocatalytic fuel cell pfc fenton reactor developed aim degrade azo dye reactive black generate electricity compared previously established system bioelectro fenton system microbial fuel cell mfc system significant challenge development operation system therefore pfc used instead mfc generate electrons fenton system effect azo dye pfc fenton reactor investigated experimental results showed maximum power output achieved absence dye fenton reactor hybrid system furthermore higher degradation efficiency could also observed pfc reactor hybrid system elsevier rights reserved
novel integration trans critical refrigeration cycle thermoelectric modules gas cooler sub cooler presented wherein two stage thermoelectric generator teg produces power waste heat gas cooler considerable amount required power two stage thermoelectric cooler tec sub cool refrigerant expansion device mathematical simulation teg tec well energy exergy based thermodynamic analysis proposed system performed effects important parameters system performance investigated comparison carried proposed system simple refrigeration cycle indicating proposed configuration improves coefficient performance cop also observed tec teg better performance two stage configuration parametric study reveals new configuration decreases cycle operation pressure maximum cop exergetic efficiency elsevier ltd iir rights reserved
novel metamaterial absorber based triple hexagonal shaped resonators proposed paper metamaterial unit cell absorber possesses nearly wide angle perfect absorption incidence wave polarization independence absorption occurred three different frequencies absorptivity high ghz ghz ghz respectively important feature metamaterial absorber easy fabrication maximum absorption observed three different frequencies proposed metamaterial absorber wide applications stealth technology thermal detector imaging moreover good agreement simulation measurement results observed
novel model hypothalamic pituitary adrenal axis presented axis endocrine system responsible coping stress likely involved depression dynamics system studied existence uniqueness positivity solution existence attracting trapping region proved model calibrated compared data healthy depressed subjects sensitivity analysis resulting set identifiable physiological parameters provided subset selected parameter estimation reduced version model stated approximated version discussed model physiologically based thus parameters representative gland functions elimination processes hence model may used pointing pathologies parameter estimation hypothesis testing whereby may used objective refined method diagnosing depression suggesting individual treatment protocols finally method may inspire pharmaceutical companies develop target specific psychopharmaca effective individual treatment elsevier inc rights reserved
novel switched flux permanent magnet machine partitioned stator structure proposed consisting conventional switched flux machine pms removed stator teeth placed secondary stator within salient rotor novel machine harnesses two distinct synergies machine design magnetically geared switched flux machines machine optimized performance compared different numbers rotor poles validated experiment machine benefits reduced copper loss improved torque density torque per magnetic volume compared conventional switched flux machines
number methods algebraic iterative developed recently fitting concentric circles previous studies focus first order analysis performance evaluation appropriate observation noise small bias insignificant compared variance studies indicate first order analysis appear sufficient explaining predicting performance estimator fitting problem especially noise level becomes significant paper extends previous study perform second order analysis evaluate estimation bias several concentric circle estimators second order analysis exposes important characteristics estimators seen first order studies insights gained theoretical study led development new estimator unbiased performs best among algebraic solutions adjusted maximum likelihood estimator also proposed yield unbiased estimate maintaining kcr bound performance
number previous studies reported potential risk malignancy particularly hematological malignancy developing patients receiving metal metal mom hip replacement report case malignant lymphoma arose patient mom hip arthroplasty complicated development pseudotumour tumour cell follicular lymphoma involved lymph nodes bone metal ions known genotoxic effect lymphoid cells although epidemiological studies established increased risk lymphoma associated mom implants relatively short time period elapsed since introduction type implant long term follow patients mom implants indicated
number studies evaluated possibility bias diagnostic criteria borderline personality disorder explanation gender differences prevalence previous studies used regression latent trait approaches results inconsistent current study extended prior investigations testing differential function borderline diagnostic criteria using regression latent trait methods sample examining diagnostic statistical manual mental disorders dsm dsm alternative model criteria borderline personality data obtained national sample clinicians providing diagnostic information target patients chronic feelings emptiness criterion demonstrated consistent evidence potential differential functioning across methods diagnostic models implications results conceptualization borderline personality discussed
numerical framework developed estimating life cycle monetary losses maintenance repair costs due wind induced damage long span bridge wind loading bridge deck evaluated means flutter derivatives fds measured wind tunnel test section model deck aeroelastic coefficients random due experimental errors statistical approach employed evaluate effects uncertainty source wind induced response damage produced structure first part study fragility curves surfaces used estimate exceedance probability representative structural performance threshold indicators accounting experimental errors estimation fds thresholds based deck acceleration user comfort peak deck displacements structural damage second part results initial fragility analysis used analyze monetary losses produced wind loading proposed model cost analysis adapted existing life cycle simulation algorithm earthquake hazards pilot study employs suspension bridge model data wind tunnel experiments conducted northeastern university united states elsevier ltd rights reserved
one dimensional multi phase flow model thermomagnetically pumped ferrofluid heat transfer proposed thermodynamic model combination simplified particle model thermodynamic equations state base fluid magnetization model based statistical mechanics taking account non uniform particle size distributions implementation proposed model validated experiments literature found give good predictions thermomagnetic pumping performance however results reveal large sensitivity uncertainties heat transfer coefficient predictions elsevier rights reserved
parallelized numerical contour integral based method proposed counting interior eigenvalues given region complex plane proposed method derived descriptor system power system linearized model complex analysis theory based computation eigenvalue number converted set matrix trace problems contour integral results able utilized detect missing target eigenvalues partial eigenvalue methods provide approximate eigenvalue distribution along integral curve efficient evaluation integral function implemented exploiting sparsity descriptor systems adaptive integral point collocation strategy proposed numerically evaluating contour integral moderate number discretized points computation integral function decoupled integral point proposed method features well parallel computing capability
parametric investigation radiative heat transfer carried including effects conjugate heat transfer fluid solid media thermal radiation simulated using model numerical model thermal coupling strategy suitable transient solver described numerical coupling requires radiative equation solved several times iteration hence computational cost radiative model crucial issue model adopted particularly fast computation first collection benchmark cases presented used carefully validate radiation model literature results analyse model prediction limits despite simplicity model satisfactorily reproduces thermal radiation effects lack accuracy identified particular cases second number benchmark cases described adopted investigate fluid solid thermal interaction presence radiation three cases designed couple radiation pure conduction conduction forced convection conduction natural convection cases surface radiative heat transfer strongly influences system thermodynamics leading significant increase fluid solid interface temperature main non dimensional numbers related mutual influence different heat transfer modes introduced employed analyses new conduction radiation parameter derived order study conductive boundary layer absence convective heat transfer elsevier ltd rights reserved
patient reported reversible pure alexia context migraine aura following previous anecdotal reports present study first formally assess word reading writing linguistic visual processing compare patient stroke related pure alexia reading impairment suggestive letter letter reading observed across days remitted month follow deficit also affected recognition letters suggesting functional impairment level letter recognition word reading went along reversible abnormalities diffusion weighted fluid attenuated inversion recovery imaging areas known involved word reading
patient long becoming subject medical scrutiny first simply storyteller narrator suffering traveler visited kingdom ill relieve illness one must begin understanding story emperor maladies siddhartha mukherjee
pelton wheel impulse turbine hydro mechanical energy conversion device converts gravitational energy elevated water mechanical work mechanical work converted electrical energy means running electrical generator kinetic energy water jet directed tangentially buckets pelton wheel water jet strikes bucket convex profile splitter get split two halves half turned backwards almost degrees relative bucket horizontal plane practically angle may vary degrees degrees normally jet energy used propelling rim bucket wheel invariably jet water misses bucket posses onto tail race without useful work hydro device good source hydro electrical energy conversion high water head present work research paper deals advanced modifications conventional pelton wheel used low head heavy discharge applications kinetic potential energy water source consumed runner wheel considerable gravitational effect water jet exploited means modifications conventional pelton wheel comparatively heavy generator run modified pelton wheel turbine low head heavy discharge conditions modified features provide enough promising opportunities use turbine mini micro hydro power plants
periodic processes scheduling problem appears flexible manufacturing systems computer systems applications paper considers approach flow shop scheduling terms real time distributed computing systems approach based concept solvable class systems simple optimal scheduling algorithms exist proposed approach belongs class fast approximate algorithms slightly falls behind known heuristic neh algorithm regarding optimality criterion much faster
phase study conducted determine dose limiting toxicities maximum tolerated dose mtd bortezomib followed romidepsin days patients relapsed refractory cll sll cell lymphoma eighteen treated patients evaluable response mtd bortezomib romidepsin median treatment duration cycles dose dose limiting toxicities grade fatigue vomiting chills two patients partial responses one lasting years stable disease progressive disease median duration stable disease cycles correlative studies examining expression kappa xiap bcl bim yielded variable results safety profile consistent reported single agent bortezomib romidepsin regimen modest activity heavily pretreated patients relapsed refractory cll cell lymphoma nct
pid controller electrical element reducing error value desired setpoint actual measured process variable pid controller operates according input parameters need set run optimal values parameters must found called tuning process today process automatized using stochastic nature inspired population based algorithms evolutionary swarm intelligence based algorithms unfortunately algorithms time consuming reactive nature inspired algorithms using limited number fitness function evaluations proposed paper two reactive evolutionary algorithms differential evolution genetic algorithm four reactive swarm intelligence based algorithms bat hybrid bat particle swarm optimization cuckoo search used tune pid controller comparative study ten individuals ten iterations generations used order select appropriate optimization algorithm fast tuning controller parameters results compared using statistical analysis showed particle swarm optimization best option task elsevier rights reserved
shaped piezoelectric harvester applied using tension vibration cables cable stayed bridge suspension bridge proposed generating output characteristics studied depending ceramic elastic body size harvester consists shaped elastic body rectangular piezoelectric ceramic attached upper surface elastic body contraction release given symmetrically ends elastic body legs bending elastic body ceramic plate occurred electricity generated piezoelectric effect ceramic structure shaped harvester advantage protect ceramic direct pressure vibration easy change design changing position legs leg length thickness generating characteristics harvester analyzed using finite element method program ansys generating characteristics harvester analyzed depending elastic body thickness ceramic size applied forces legs harvester fabricated basis analyzed results frequency controllable vibrator used measure output characteristics generating output characteristics single harvester arrayed harvesters measured elsevier ltd techna group rights reserved
planar serial manipulator well suited industrial applications aided automation manufacturing engineering applications space robots excavators pump trucks well medical applications orthopaedic surgery robotics micro holder tactile sending fingers study presents detailed discussion classification joint angle ranges solution space atlases analysis design planar serial manipulators planar manipulators categorized three classes several sub classes based link lengths terms joint angle ranges furthermore improved bounded solution space proposed display global performances manipulators leads design global optimization besides joint angle ranges manipulator displayed characteristics charts relation assembly orders manipulator links finally case studies illustrate presented idea elsevier ltd rights reserved
potential problem persisting large volume streaming logs conventional relational databases loading large volume data logs produced high rates fast enough due strong consistency model high cost indexing possible alternative state art nosql data stores sacrifice transactional consistency achieve higher performance scalability utilized paper describe challenges large scale persisting analysis numerical streaming logs propose develop benchmark comparing relational databases state art nosql data stores persist analyze numerical logs benchmark investigate degree state art nosql data store achieve high performance persisting large scale analysis data logs benchmark serve basis investigating query processing indexing large scale numerical logs
power operated detrasher developed removal green top well dry trash harvested sugarcane stalks consisted mechanisms cane feeding detrashing delivery separates top cane breaking natural weak point joint immature top mature cane stalks transported three point linkage tractor operated electric motor diesel engine tractor pto performance equipment evaluated feeding different varieties harvested canes tops first detrashing rollers feeding chute trash left cane passing detrasher varied trash removal efficiency varied depending upon variety output detrasher saving cost operation labour requirement using detrasher compared manual method
precondition successful treatment headaches correct headache diagnosis triptans effective attack treatment migraine cluster headache however effective treatment tension type headache prevention frequent episodic migraine betablockers flunarizine topiramate amitriptyline recommended prevention chronic migraine evidence available onabotulinumtoxina topiramate prophylactic treatment tension type headaches tricyclic antidepressants used cluster headache verapamil combination steroids frequently used prophylactic agent article focusses current acute prophylactic treatment common headache syndromes
prerequisite reliable hydraulic measurements accurate collection plant material thereby native hydraulic state sample preserved harvesting cutting plant plant parts preparation excising target section particularly difficult harvesting done transpiring conditions article present harvesting sampling protocol designed hydraulic measurements malus domestica borkh checked possible sampling artefacts test artefacts analysed percentage loss hydraulic conductivity maximum specific conductivity water contents bark wood branches taking account conduit length time day harvesting different shoot ages seasonal effects results prove use appropriate protocols avoid artefactual embolization refilling even xylem tension harvest presented protocol developed malus may also applied angiosperms similar anatomy refilling characteristics
prerequisite simulating biophysics complex biological tissues whole organisms computational descriptions biological matter flexible interface materials different viscosities liquid landscape software easily available work limited lacks essential features necessary combining elastic matter simulations liquids present open source software package called sibernetic designed physical simulation biomechanical matter membranes elastic matter contractile matter environments liquids solids elastic matter variable physical properties core sibernetic built extension predictive corrective incompressible smoothed particle hydrodynamics pcisph sibernetic built top opencl making possible run simulations cpus gpus visualization support built top opengl several test examples software running reproducing physical experiments well performance benchmarks presented future directions discussed elsevier ltd rights reserved
previous article published prevention science years ago heinrichs presented results randomized controlled trial triple group program years administration universal prevention approach preschools present addendum resolves inconsistencies outcome reporting total scores scales versus subscale scores provides information measures additionally available analyze potential effects intervention effects secondary outcome domains reported heinrichs furthermore analyzed reported original data analyses varied using different statistical model addendum analyses supported original results including changes self reported maternal paternal positive parenting maternal dysfunctional parenting behavior well maternal reports child behavior addition analyzing externalizing internalizing dimensions analysis revealed statistically significant change externalizing internalizing child symptoms significant intervention effects found secondary outcome domains considering important limitations study design baseline differences pre assessment mothers intervention preschools reporting child behavioral problems prior introducing intervention predominantly non significant effects fathers perspective teacher ratings year follow behavioral observations believe trial alone taken sufficient evidence significant meaningful change child behavioral problems ultimate goal child prevention programs therefore future studies need replicate extend upon results including larger sample sizes overcome discussed limitations
prominent software security violation buffer overflow attack taken various forms poses serious threats today one vulnerability return oriented programming attack return oriented programming attack circumvents dynamic execution prevention employed modern operating systems prevent execution data segments attempts execute unintended instructions overwriting stack exploiting buffer overflow vulnerability numerous defense mechanisms proposed past years mitigate prevent attack compile time methods add checking logic program code compilation dynamic methods monitor control flow integrity execution randomization methods aim randomizing instruction locations paper discusses different static dynamic randomization techniques proposed recently compares techniques based effectiveness performances copyright john wiley sons ltd
proton exchange membrane pem electrolyser characterised modelled identify important electrochemical effects electrochemical effects include ohmic activation concentration losses within pem electrolyser hydrogen production electrochemical effects pem electrolyser modelled means equivalent electrical circuits equivalent electrical circuit components importance membrane resistance charge transfer resistance double layer capacitance warburg impedance current interrupt method proposed using natural voltage response method system identification solving parameters equivalent electrical circuits paper simulation experimental results provided
prototype heat exchanger proposed exhaust heat recovery means pulsating heat pipe device made exhaust channel air channel row pulsating heat pipes filling ratio ethanol silver nano fluid working fluids exhaust hot gas combustion natural gas feeds device exergy analysis device inlet outlet temperatures hot gas cold air measured appropriate devices exergy flow exergetic efficiency system calculated different inlet temperatures calculations carried two distinct working fluids within heat pipes energy analysis results show ethanol inlet smoke temperature degrees best functionality exergy analysis also demonstrated better performance silver nano fluid compared ethanol use silver nano fluid instead ethanol increases exergy efficiency much decreases exergy losses much elsevier ltd rights reserved
psychotropic drug defined drug capable affecting mind emotions behavior denoting drugs used treatment mental illnesses medical dictionary health professions nursing use drugs lead urinary dysfunction often difficult delineate whether urinary dysfunction direct indirect result drug use secondary unrelated concurrent condition situation therefore result diagnostic management dilemmas urologists psychiatrists primary care physicians article reviews literature published last years provides update desirable undesirable effects psychotropic drugs lower urinary function duloxetine antidepressant efficacy treatment stress urinary incontinence addition duloxetine desipramine proposed treatment overactive bladder laboratory research potential therapies target role neurotrophins lower urinary tract function progress narcotic analgesia several antipsychotics antidepressant anticonvulsant stimulant medications associated urinary retention several antidepressants associated nocturnal enuresis furthermore ketamine known induce storage symptoms reduction bladder capacity lower urinary tract symptom luts causing drugs associated polypharmacy elderly patients particularly susceptible adverse events due pharmacotherapy awareness psychotropic drug side effects rationalization use important avoid undesirable outcomes patients bothersome luts psychotropic drugs fail benefit simple first line treatments luts clinicians mindful psychotropic drug may indeed cause luts seek liaise patient psychiatrist primary care physician discuss reasonable alternatives
quickest change detection qcd algorithm proposed address problem detecting identifying line outages power system statistics electricity demand assumed known propagated linearized model equations describing power flow balance node network proposed algorithm incorporates transient dynamics power system following line outage applied measurements voltage phase angles collected using phasor measurement units adaptive algorithm developed treating qcd problem dynamic composite hypothesis testing problem shown superior performance compared line outage detection algorithms previously proposed literature case studies demonstrating gain performance illustrated ieee bus test system
randomized controlled parallel group study perform compare clinical efficacy semi rigid bandage scotchrap standard adhesive tape treatment ankle ligament injuries semi rigid bandage support wrap consists knitted fibreglass fabric impregnated polyurethane resin cotton stockinet synthetic cast padding used protection pressure points bony prominences prior application scotchrap must soaked water applied way similar used plaster paris bandage finished bandage remains elastic allowing normal dorsal plantar flexion foot preventing inversion eversion pronation supination rest bandage always redresses immobilized ankle neutral position one hundred thirty six patients included study semi rigid bandage group comprised patients tape group patients two groups statistically comparable intake questionnaire included general specific anamnesis form well physical examination form follow data recorded every weeks termination treatment patients evaluated treatment efficacy statistical analysis items per patient chi tests less equal fisher exact tests less equal revealed statistical significant differences treatment result patient assessments treatment efficacy types bandage also comparable types bandage gave sufficient stability equally effective study shown scotchrap used lateral ankle ligament lesions excellent short term results technique application scotchrap bandage easy learn must considered thoroughly change technique lead changes rigidity bandage early wastage semi rigid bandage also used functional treatment patients allergic tape interest fields application new material used orthopaedic corsets treatment knee arthroscopies achilles tendon ruptures even wrist fractures concluded alone combination cast immobilization techniques semi rigid scotchrap bandage represents welcome useful contribution existing assortment bandage materials
recent development video games players design personalize game characters predicted innovation could lead elevations intensity psychological effects video games present study confirmed hypothesis revealing participants played aggressive video game using personalized character exhibited higher levels aggressive behavior participants played aggressive game non personalized character aggressive behavior levels character players also exceeded individuals played non aggressive game regardless whether used personalized character process analyses revealed participants playing violent video game personalized game character experienced arousal self activation playing impersonal default game character turn increased aggressive responses elsevier inc rights reserved
recent study hassabis suggests brain constructs personality models people imagining another individual multi voxel patterns fmri activation medial prefrontal cortex mpfc contained information individual unique combination personality traits authors propose concert regions mpfc assembles model another personality ultimately used predict behavior
recently proposed hyperfocusing hypothesis cognitive dysfunction schizophrenia proposes people schizophrenia psz tend concentrate processing resources narrowly intensely healthy control subjects hcs present study tests key prediction hypothesis namely psz hyperfocus information presented center gaze lead greater filtering peripheral stimuli task requires focusing centrally reduced filtering central stimuli task requires attending broadly periphery predictions tested double oddball paradigm frequent standard stimuli rare oddball stimuli presented central peripheral locations event related potentials recorded participants instructed discriminate standard oddball stimuli either central location peripheral locations psz hcs showed opposite patterns spatial bias level early sensory processing assessed component psz exhibited stronger sensory suppression peripheral stimuli task required attending narrowly central location whereas hcs exhibited stronger sensory suppression central stimuli task required attending broadly peripheral locations moreover psz exhibited stronger stimulus categorization response hcs assessed component central stimuli task required attending peripheral region results provide strong evidence hyperfocusing psz may provide unified mechanistic account multiple aspects cognitive dysfunction schizophrenia
reduced order model transient diesel spray combustion presented utilizes simplified fluid mechanics detailed chemical kinetics premised similarity dense turbulent gaseous jets diesel sprays engine conditions presented model offers new capability detailed chemistry predictions transient diesel sprays since use large chemical mechanisms prohibitively expensive detailed modeling approaches multidimensional computational fluid dynamics numerical model validated engine combustion network spray experimental data predictions vapor penetration axial mixture fraction distribution ignition delay axial location cool flame reaction end injection combustion recession show excellent agreement experimental measurements model applied study modern diesel injection strategies involve significant transient mixing combustion behavior including fuel injection rate shaping close coupled split injection strategies general model shown enable detailed examination modern diesel injection strategies expected impact strategies emissions slow ramp fueling rate end injection found limit mixing near field injector enabling recession second stage ignition toward injector end injection advantageous consumption unburned hydrocarbons improved combustion efficiency compared slow ramp injection strategies close coupled split injections less effective unburned hydrocarbon reduction due strong end injection entrainment wave accompanies injections causing rapid leaning recession second stage ignition
research carried dynamic analysis simulation parallel robots due situation parallel robots tend break account large stress movements order study force condition robot move mathematical model based kane method built driving force electric cylinder calculated computer programming meantime dynamic simulation model simulation control system established basis adams matlab analyzing joint simulation obtain driving force cylinder gap simulation results results obtained mathematical model within verifies correctness kane dynamic system gives provide foundation future studies dynamics structure optimization
review provided efforts laboratory last decade discover anti hiv agents work focused computer aided design synthesis non nucleoside inhibitors hiv reverse transcriptase nnrtis collaborative efforts biological assaying protein crystallography numerous design issues successfully addressed including need potency wide range viral variants good aqueous solubility avoidance electrophilic substructures computational methods including docking novo design free energy perturbation fep calculations made essential contributions result novel nnrtis picomolar low nanomolar activities wild type hiv key variants also show much improved solubility lower cytotoxicity recently approved drugs class elsevier ltd rights reserved
review epidemiological studies incidence mrsa infections overtime performed along analysis data available download hospital compare https data medicare gov data hospital compare found estimations incidence mrsa infections varied widely depending upon type population studied types infections captured definitions terminology used describe results could find definitive evidence incidence mrsa infections community facilities decreasing significantly concern recent data reported national healthcare safety network nhsn mrsa bloodstream infections indicate end little change average facility standardized infection ratio compared baseline significantly increased compared previous year contradistinction recent veterans administration study reported reduction mrsa infections however discrepancy may due inability reconcile baselines two data sets observed increase may artifactual due aberrations nhsn tracking system review supports need implementation comprehensive tracking monitoring system involving types healthcare facilities multi drug resistant organisms along concomitant funding staff infrastructure without system determining effectiveness interventions antibiotic stewardship chlorhexidine bathing hindered
sample nanomaterial contains distribution nanoparticles various shapes sizes scanning electron microscopy image sample often captures fragment morphological variety present sample order quantitatively analyse sample using scanning electron microscope digital images particular derive numerical representations sample morphology image content assessed work present framework extracting morphological information contained scanning electron microscopy images using computer vision algorithms converting numerical particle descriptors explore concept image representativeness provide set protocols selecting optimal scanning electron microscopy images well determining smallest representative image set morphological features demonstrate practical aspects methodology investigating tricalcium phosphate calcium hydroxyphosphate naturally occurring minerals wide range biomedical applications lay description typical sample nanomaterial contains distribution nanoparticles various shapes sizes single scanning electron microscopy sem image sample often captures fragment sample therefore fragment morphological variety present sample order obtain complete information true sample morphology one needs asses content series sem images article present framework extracting morphological information contained sem images using computer vision algorithms converting numerical particle descriptors representing particle morphology explore concept image representativeness provide set protocols selecting optimal sem images well determining smallest representative image set morphological features demonstrate practical aspects methodology investigating sem images tricalcium phosphate sample naturally occurring mineral wide range biomedical applications
self sustaining sensor platform core component internet things smart grid systems however monitoring processing displaying minute changes targeted environmental element real time fashion without external power sources challenging practical difficulty energy harvesting analysis dynamics time present self sustaining water motion sensing wms platform monitor display time varying dynamics water motion frequency amplitude using energy harvested water motion water contact triboelectric nanogenerator teng produces electrical energy correlated repetitive squeezing releasing water droplet wms integrated circuit harvests energy simultaneously analyzes dynamics water motion converted binary codes displayed leds powered gathered energy proposed platform would contribute advanced sensing functions self sustaining system various targeted ambient elements
series experiments conducted flume study bed load transport motion bed load particles captured series images taken high speed camera novelparticle motion tracking method developed automatically detect moving particles calculate instantaneous particle velocities instantaneous bed load transport rate calculated based particle velocity volume moving particles verify method bed load transport rate based image processing technique compared manually measured ones well data experiments results showed new technique made possible quantify spatial temporal variations bed load transport rate individual particle scale international research training centre erosion sedimentation world association sedimentation erosion research published elsevier rights reserved
series heterocyclic ring fused tricyclic diterpene analogs synthesized inhibitory effects rankl induced osteoclastogenesis evaluated bone marrow derived monocytes bmms cell based tartrate resistant acid phosphatase trap activity assay among potent compound showed inhibition even low concentration fold potent lead compound cytotoxicity test bmms indicated inhibition osteoclast differentiation result cytotoxicity moreover also showed obvious effect osteoblast differentiation mechanistic studies disclosed inhibit expression osteoclastogenesis related marker genes including nfatcl trap cathepsin src ctr particular could decrease ovariectomy induced osteoclast activity relieve osteoporosis obviously vivo therefore tricyclic diterpene analogs could served promising leads development new class antiresorptive agents elsevier masson sas rights reserved
series neurological psychiatric symptoms occur traumatic brain injury tbi cognitive dysfunction one prominent sequela given tau hyperphosphorylation important cause cognitive impairment patients alzheimer disease present study detected presence hyperphosphorylated tau tau mainly ser multiple brain regions including ipsilateral parietal cortex contralateral hippocampus prefrontal cortex immediately injury mouse tbi model changes lasted least brain regions play important roles working memory hyperphosphorylated tau protein primarily located neurons accompanied axonal injury dendritic spine degeneration study demonstrated tau spreads gradually selectively injured cortex brain regions tbi affected regions part working memory circuit findings provide experimental support role tau cognitive impairment early phase tbi elsevier rights reserved
simple technique electronically shape power distribution microwave focused beam near field range proposed experimentally demonstrated letter technique based use multitone microwave input signal spatially scattered due frequency scanning response leaky wave focused applicator synthesis procedure based minimax algorithm applied optimize frequencies power amplitudes multitone signal experiments using multitone signals ghz band microstrip leaky wave line reported showing ability dynamically shape near field focus steering position range controlling focal depth showing electronic generation multifocused spots complementary power distributions
simplified method accurate prediction natural frequencies cable stayed bridges proposed paper proposed method artificial neural network ann applied derive simple formula predict natural frequencies cable stayed bridges based existing natural frequency data unlike existing empirical methods functional relationship among variables assumed develop ann model ann automatically constructs relationships adapts based training data presented also proposed method takes account wide range parameters may significant effect natural frequencies cable stayed bridges proposed method particularly useful preliminary design stage cable stayed bridges free vibration analysis needs carried proposed method compared two existing empirical methods found simplified method proposed study produce accurate prediction natural frequencies cable stayed bridges existing empirical methods
simplified highly reliable cost effective high temperature vertical dilatometer system based linear variable differential transformer lvdt designed fabricated tested measurement linear thermal dilation solid samples unique features fully automated controlled system simple design fabrication locally available components ease operation maintenance good temperature resolution wide measurement range resolution microcontroller based data acquisition hardware simple windows based software system tested performance using nist sapphire reference high purity metals including aluminum nickel overall accuracy system measurement linear thermal dilation within reported values nist sapphire system good example simple experimental facility routine thermal expansion characterization solids combination simplified design automation reliable performance without using sophisticated instrumentation control systems makes novel cost effective thermo analytical equipment put widespread routine usage researchers academy small medium scale industries elsevier ltd rights reserved
simulation model current rotary drilling rig rdr system built according basic configuration trd type rotary drilling rig test rig based working principle rdr system built results show simulation model rdr system accurate reasonable means comparative analysis theoretical computation test data working principle logic threshold control method hdr system presented reduce fuel consumption improve energy saving efficiency via analysis energy flow rdr system mainly includes engine electric motor generator super capacitor rectifier inverter torque coupler etc finally comparative analysis fuel economy rdr hybrid drilling rig hdr system completed overall typical operating conditions results show energy saving efficiency hdr system total fuel economy efficiency hdr reaches relatively typical operating condition istvs published elsevier ltd rights reserved
simultaneous bidirectional transceiver single wire developed cmos technology command control bus echo signals simultaneous bidirectional link cancelled controlling decision level receiver comparators without power hungry operational amplifier amp based circuits clock information embedded rising edges signals sent source side sink side data recovered open loop digital circuit times blind oversampling data rate simultaneous bidirectional transceiver direction mbps therefore overall signaling bandwidth mbps measured energy efficiency transceiver bit error rate ber less pseudo random binary sequence prbs pattern signaling directions
single semester molecular biology laboratory developed students design execute project examining transcriptional regulation saccharomyces cerevisiae three weeks planning allocated developing hypothesis literature searches use bioinformatics common experimental plans address cell process three genes encode proteins involved process transcriptionally regulated response changing environmental conditions planning includes designing oligonucleotides amplify putative promoters three genes interest pcr product cloned proximal galactosidase yeast reporter plasmid techniques used include agarose electrophoresis extraction dna agarose plasmid purification bacteria restriction digestion ligation bacterial transformation promoter reporter plasmid transformed yeast transformed yeast cultured conditions prescribed experimental design lysed beta galactosidase activity measured course provides independent research experience group setting notebooks maintained line regular feedback projects culminate presentation poster worth grade last three years students met expectations experimental design data acquisition analysis international union biochemistry molecular biology
straightforward facile method exfoliation graphene sheets using poly vinylpyrrolidone nanoparticles average size developed dual role sensitive drug carrier anti cancer agent evaluated cytotoxic impact exfoliated nanosheets grp pvp examined various cells hct hela scc nih hek cells series assays cytotoxic nature attributed affecting mitochondrial enzyme activity proliferation capability formation tight junctions cancer cells endocytosis found internalization mechanism cellular uptake nanosheets generation reactive oxygen species elicitation caspase activity undoubtedly associated triggering oxidative stress speculated dominant cause cytotoxic pattern nanosheets cancer cells additionally results also showed role nanosheets sensitive drug carrier drug loading supramolecular interaction efficient release doxorubicin seen low environment low oxygen concentration thus conditions mimicking typical tumor microenvironment therefore findings provide first evidence dual function exfoliated graphene sheets also elucidate cytotoxic mechanism responsible cancer cell death elsevier inc rights reserved
study hydrodynamic modelling pontoon bridges presented exemplified bergsoysund bridge structural modelling based finite element method using software abaqus fluid structure interaction well wave action modelled applying linearized potential theory represented dnv hydrod wadam software main emphasis put stochastic response analysis within framework power spectral density method accuracy presented modelling outlined convergence response obtained modal technique dealt means state space representation iteration algorithm quadratic eigenvalue problem solved contribution fluid structure interaction overall modal damping presented discussed found significant critical damping ratios close corresponding modes natural frequency around rad found displacement response considered near converged approximately modes included
summary appropriate time initiate bisphosphonate treatment fragility fracture yet established study found significant differences short term functional recovery femoral neck fracture patients received bisphosphonate treatment versus weeks hemiarthroplasty introduction bisphosphonate mainstay therapy prevention treatment osteoporosis aim study investigate effect bisphosphonate initiation short term functional recovery femoral neck fracture patients versus weeks hemiarthroplasty methods one hundred patients randomly allocated two groups parallel group designed randomized controlled trial groups received risedronate week either weeks hemiarthroplasty patients received calcium vitamin supplementation functional recovery assessed morton mobility index barthel index euroqol visual analog scale min walk test timed get test weeks months year surgery results month follow functional outcome measures showed significant improvement groups statistically significant differences functional outcomes groups month year follow ups although patients received bisphosphonate initiation week lower serum calcium level months overall adverse events patients week group patients either group discontinued prescribed medications conclusions underpowered findings study suggest significant differences short term functional recovery significant adverse events two bisphosphonate groups thus initiation bisphosphonate therapy may considered early weeks femoral neck fracture important low serum calcium vitamin status must corrected calcium vitamin supplementation prior time bisphosphonate initiation clinical trial registration number study registered database via protocol registration results system prs nct
summary social work practice role substance use often encountered context social problems child abuse domestic violence article compares descriptions important factors initiating maintaining positive changes among male female clients treated alcohol drug problems results bearing substance use treatment areas social work practice problems encountered studies highlighting gender perspective indicate differences regarding experience alcohol drug problems treatment advantage study qualitative analysis rather comprehensive material enabling general conclusions previous research limited number clients findings women often men stress poor mental health children important initiating change referring partners women report abusive rather supportive partners opposite applies men maintaining change male clients often stress changes ways thinking feeling important men also report becoming sensitive women get active understood transcending gender possibilities broader repertoire act applications challenge practical treatment work create possibilities clients broaden repertoire ways living thinking expressed women importance taking space speaking men showing emotion listening
system described determination discrete pulse train characteristics multi spot laser delivery systems retinal photocoagulation photodiodes provide ideal detection mechanism measurement artifacts potentially introduced spatial pattern delivered beam relative discrete photodiode element problem overcome use integrating sphere produce uniform light field site photodiode detector basic current driven photodiode detection circuit incorporating operational amplifier used generate signal captured commercially available usb interface device rate khz studies undertaken topcon pascal streamline laser system output wavelength yellow laser features proprietary feature endpoint management pulses delivered set energy levels visible reaction retina also reduced energy level create potentially non visible clinically effective lesions using pulse train measurement device identified endpoint management delivery mode pulses lower energy achieved reducing pulse duration pulses non visible effect pulses maintaining consistent beam power levels within delivered pulse profile effect eye geometry determining safety effectiveness multi spot laser delivery retinal photocoagulation discussed ipem published elsevier ltd rights reserved
tangent vector field surface generator smooth family maps surface known flow given scalar function surface transported advected composing vector field flow transport exhibited many physical phenomena fluid dynamics paper interested inverse problem given source target functions compute vector field whose flow advects source target propose method addressing problem minimizing energy given advection constraint together regularizing term vector field approach inspired similar method computational anatomy known lddmm yet leverages recent framework functional vector fields discretizing advection flow operators scalar functions latter allows efficiently generalize lddmm curved surfaces without explicitly computing flow lines vector field optimizing show two approaches solution using linear advection multiple vector fields using non linear advection single vector field additionally derive approximated gradient corresponding energy based novel vector field transport operator finally demonstrate applications machinery intrinsic symmetry analysis function interpolation map improvement
theoretical analysis generation electrical streaming currents electrical power two phase flow rectangular capillary presented injection second non conducting fluid phase tends increase internal electrical resistance electrical generator thereby increasing power output viscosity injected fluid large resulting high shear rate low viscosity fluid wall generates large streaming current power generated enhanced however injected fluid viscosity low wall shear rate viscous suspending fluid reduced streaming currents power generation would small capillary effects ends bubbles increase pressure drop along capillary expected annular flow
theoretical experimental study microcontroller based dual axis automatic solar tracking system asts presented paper panel rotates automatically based intensity sun light asts helps keeping solar panels aligned sun order obtain maximum solar power instance particular alignment intensity light decreasing system ability automatically redirect get maximum intensity light light energy detected four llight dependent resistor ldr sensors located surface photovoltaic panel two servo motors employed move solar panel direction maximum luminous intensity design construction small prototype asts presented measured efficiency fixed solar panel
three year old girl observed bluish marks back arms legs social services initiated examination local hospital conclusion regarding marks reached girl institutionalized forensic examination three days concluded marks mongolian spots case stresses importance able distinguish mongolian spots skin hematomas need genuine clinical forensic examination cases child abuse suspected guide distinguishing mongolian spots skin hematomas presented
three degrees freedom dof coupled numerical simulation technique synchronously extracting aerodynamic derivatives bridge decks proposed evaluated study computations performed finite volume unstructured computational flow dynamics cfd solver using two dimensional hybrid meshes fine near wall resolution accuracy numerical model verified identifying aerodynamic derivatives one thin plate section theoretical solutions two typical deck sections streamlined bluff two long span bridges extracted aerodynamic derivatives coupled uncoupled techniques compared results showed good agreement experimental results proposed dof coupled method provide almost level accuracy dof method saves computation time appropriateness linear superposition theorem aeroelastic forces generated different motions single coupled mode examined found significant differences aerostatic aeroelastic forces various high order aeroelastic force components successfully captured newly presented coupled numerical simulation aerodynamic derivatives proved immune high order components mathematically knowledge essential thorough evaluation aerodynamic derivatives identification accuracy proposed technique analytical viewpoints presented paper may serve building block developing new numerical tools analytical frameworks rapid accurate evaluation aerodynamic derivatives response long span flexible bridges wind excitation american society civil engineers
vast majority menopausal women suffer vasomotor symptoms hot flushes night sweats mean duration may years addition decreased quality life vasomotor symptoms may impact overall health vasomotor symptoms associated overactivity sympathetic nervous system sympathetic overdrive turn associated metabolic syndrome known risk factor cardiovascular disease menopausal hot flushes complex relationship different features metabolic syndrome data point towards association vasomotor symptoms metabolic syndrome thus still unclear whether vasomotor symptoms independent risk factor metabolic syndrome research area constantly evolving present recent data possible association menopausal vasomotor symptoms metabolic syndrome elsevier rights reserved
ventricular septal defect common congenital cardiac abnormality encountered infants children many survive adulthood diagnosis two thirds cases involve membranous part septum absence interventricular shunt concomitant cardiac surgery guidelines surgical intervention resection isolated aneurysms membranous septum well established report discuss multi imaging modality approach diagnosis assessment membranous ventricular septal aneurysms review experts consensuses follow treatment strategies
promising concept small range extenders peak power less represented stroke direct injection spark ignition engine scavenging exhaust ports controlled piston external pump important issue addressed type engines compliance stringent rules pollutant emissions depends combustion patterns quality scavenging process latter generally hindered symmetry ports timings handicap canceled adopting patented rotary valve controlling flow set auxiliary transfer ports using piston pump delivering air power cylinder enhancing balance crankshaft paper reviews design virtual engine rated rpm developed according mentioned concepts design driven cfd simulation using whenever possible experimentally calibrated numerical models experimental information derived similar projects particular care devoted characterize scavenging process flow patterns within cylinder ports analyzing influence rotary induction valve engine performance parameters predicted using well established commercial software power gamma technologies cfd analyses carried means customized version kiva code whole study conceived basis construction physical prototype power target virtually achieved light compact engine estimated weight without close coupled electric motor three way catalyst allows engine comply stringent emission regulations without relevant penalizations fuel efficiency furthermore engine work lean mixtures achieving minimum specific fuel consumption comparable current automotive diesel engine kwh excellent result due low friction pumping losses stroke engine well compactness combustion chamber capability stratify charge
voltage controlled hydraulic actuator presented employs electroosmotic fluid flow eof paper microchannels within elastomeric structure microfluidic device fabricated using new benchtop lamination process flexible embedded electrodes formed conductive carbon silicone composite pores layer paper placed electrodes served microchannels eof pumping fluid propylene carbonate sealed fluid filled chamber formed film casting silicone lay actuating membrane pumping liquid hydraulic force generated eof caused membrane bulge hundreds micrometers within fractions second potential applications actuators include soft robots biomedical devices
wide spectrum extranodal lymphomas abdomen pelvis commonly encountered imaging diagnosing lesions generally requires multi modality approach review highlights imaging appearances extranodal lymphomas abdomen pelvis emphasis computed tomography magnetic resonance imaging positron emission tomography computed tomography along relevant differential diagnosis
wide variety large scale data produced bioinformatics response need efficient handling biomedical big data partly met parallel computing however time demand many bioinformatics programs still remains high large scale practical uses factors hinder acceleration parallelization recently new generations storage devices emerged nand flash based solid state drives ssds renewed interest near data processing increasingly becoming acceleration methods accompany parallel processing certain cases simple drop replacement hard disk drives ssds results dramatic speedup despite various advantages continuous cost reduction ssds little review ssd based profiling performance exploration important time consuming bioinformatics programs informative review perform depth profiling analysis key bioinformatics programs using multiple types devices based insight obtain research discuss issues related design optimize bioinformatics algorithms pipelines fully exploit ssds programs profile cover traditional emerging areas importance alignment assembly mapping expression analysis variant calling metagenomics explain acceleration parallelization combined ssds improved performance also using ssds expedite important bioinformatics pipelines variant calling genome analysis toolkit transcriptome analysis using rna sequencing hope review provide useful directions tips accompany future bioinformatics algorithm design procedures properly consider new generations powerful storage devices
wide variety predictive analytics techniques developed statistics machine learning data mining however many algorithms take black box approach data input future predictions output insight goes process unfortunately closed system approach often leaves little room injecting domain expertise result frustration analysts results seem spurious confusing order allow human centric approaches visualization community begun developing methods enable users incorporate expert knowledge prediction process stages including data cleaning feature selection model building model validation paper surveys current progress trends predictive visual analytics identifies common framework predictive visual analytics systems operate develops summarization predictive analytics workflow
wide bandwidth power efficient continuoustime sigma delta modulator sigma delta presented modulator introduces third order filter implemented lossless integrator multiple feedback single amplifier biquadratic filter embedded loop stability compensation active summing block implemented employing common gate current buffer followed transimpedance amplifier combination relaxes specification requirements operational amplifier making required independent closed loop gain proposed technique achieves optimum reduced power consumption making functional gigahertz operation fabricated standard cmos technology clocked ghz sigma delta achieves signal noiseand distortion ratio mhz bwwhile consuming power obtained walden figure merits conv step
wireless sensor network wsn consists energy limited autonomous tiny devices spatially distributed monitor environments wide application domain ranging military applications health care services logistics agriculture efficient use sensor energies network security utmost importance given possible application domains operational properties multipath routing multi copy forwarding well known approaches shown useful several threats paper study design energy efficient reliable wsn discuss four different routing strategies multipath routing various levels multi copying namely full partial redundancy cases moreover incorporate balanced energy dissipation models improve network lifetime time first sensor network exhausts energy also eliminate critical nodes appealing malicious attacks construct mathematical models protocols present test results display trade energy efficiency network reliability compare performance terms network lifetime amount data successfully transmitted case inconvenience full data redundancy protocol yields reliable design balanced utilization redundancy partial redundancy protocols exchange quite significant degradation network lifetime however partial redundancy protocol provides slightly less reliable wsn full redundancy case almost longer lifetime result suggest partial multi copy protocol extended balanced utilization rule quite favourable operating networks energy efficiently securely
working knowledge contraception assist pediatrician sexual health promotion well treatment common adolescent gynecologic problems best practices adolescent anticipatory guidance screening include sexual health history screening pregnancy sexually transmitted infections counseling indicated providing access contraceptives pediatricians long term relationships adolescents families allow help promote healthy sexual decision making including abstinence contraceptive use additionally medical indications contraception acne dysmenorrhea heavy menstrual bleeding frequently uncovered adolescent visits technical report provides evidence base accompanying policy statement addresses key aspects adolescent contraceptive use including following sexual history taking confidentiality counseling adolescent data use side effects newer contraceptive methods new data older contraceptive methods evidence supporting use contraceptives adolescent patients complex medical conditions
working theoretical model irritable bowel syndrome ibs functional gastrointestinal disorders fgids exist hampered lack clear cut invention address symptom signs disease reports cessation symptom signs major types ibs published using non systemic topically active agent high potency polymerized cross linked sucralfate hppcls unique clinical effect non systemic agent restricted luminal surface gut provides opportunity elaborate alternative working model pathogenesis ibs fgids chemical determinants hppcls mucosal lining contribute clinical effects sequence events resides functional interplay among elements within mucosa proposed model assumes failure pre existing genomic controlled surveillance epithelium localized luminal surface triggers primary secondary immune activation inflammation intent restoring epithelial homeostasis delayed restoration homeostasis results symptoms signs likely molecular events characterize ibs fgids
abaca musa textilis reinforced polypropylene composites prepared flexural mechanical properties studied due characteristic properties textilis great economic importance fibers used specialty papers due high price despite possessing distinctive mechanical properties date abaca fibers tested fiber reinforced composites analysis materials prepared showed spite reduced interface adhesion flexural properties composites increased linearly fiber content addition maleated polypropylene coupling agent still enhanced stress transfer matrix reinforcement fiber result composites improved flexural properties obtained mechanical properties matrix reinforcing fiber evaluated used modelling flexural strength modulus composites addition impact strength materials evaluated comparison mechanical properties composites reinforced fiberglass points potentiality abaca reinforced polypropylene composites suitable substitutes applications low impact strength demands elsevier ltd rights reserved
abnormal buildup microtubule associated protein tau major pathological hallmark alzheimer disease various tauopathies mechanisms pathological tau accumulates spreads throughout brain remain largely unknown previously demonstrated restoration major astrocytic glutamate transporter glt ameliorated buildup tau pathology rescued cognition mouse model hypothesized aberrant extracellular glutamate abnormal neuronal excitatory activities promoted tau pathology present study investigated genetic interactions tau glt homolog deaatl drosophila melanogaster neuronal specific overexpression human wildtype tau markedly shortened lifespan impaired motor behavior rnai depletion deaatl astrocytes worsened phenotypes whereas overexpression deaatl improved however synaptic neuropil appeared unaffected failed detect major neuronal loss tau overexpression combination deaatl depletion mimic glutamate induced aberrant excitatory input neurons repeated depolarization neurons via transgenic trpa applied adult drosophila optic nerves examined change tau deposits repeated depolarization significantly increased accumulation tau neurons propose increased neuronal excitatory activity exacerbates tau mediated neuronal toxicity behavioral deficits ibro published elsevier ltd rights reserved
abnormalities thyroid function common endocrine disorders affect general population hypothyroidism occurring frequently hyperthyroidism clinical symptoms signs often nonspecific particularly hypothyroidism muscular symptoms stiffness myalgias cramps easy fatigability mentioned majority patients frank hypothyroidism often underestimated fact muscle symptoms may represent predominant clinical manifestation hypothyroidism raising issue differential diagnosis causes myopathy sometimes difficult elevated serum creatine kinase necessarily correlates severity myopathic symptoms certainly suggestive muscle impairment though explain cause rare muscular manifestations associated hypothyroidism rhabdomyolysis acute compartment syndrome hoffman syndrome kocher debre semelaigne syndrome though pathogenesis hypothyroid myopathy entirely known proposed mechanisms include altered glycogenolytic oxidative metabolism altered expression contractile proteins neuro mediated damage correlation studies haplotype muscle gene expression protein characterization could help understanding pathophysiological mechanisms myopathic presentation hypothyroidism
aboriginal canadian patients end stage kidney disease receive disproportionately fewer transplants non aboriginal patients reasons poorly understood likely complex qualitative study employed thematic analysis depth interviews canadian kidney health professionals programs across canada explore perspective disparity individual level factors commonly reported barriers aboriginal patients accessing transplants notable patients remote living location understanding role place barrier accessing care lived experiences aboriginal patients emerged key research priorities elsevier ltd rights reserved
accelerator driven system ads promising technique reducing amount long lived fission products safe manner consists subcritical core coupled accelerator means spallation target arrangement thermal hydraulics spallation target great complexity due multiphase flow cavitation coupling spallation reaction paper firstly obtain steady state flow pattern lead bismuth eutectic lbe target based flow pattern heat deposition different proton beam energy calculated via nuclear physics simulation heat deposition imported cfd calculation study process heat transfer transient temperature distributions different proton beam energy calculated observed shape temperature distribution varies proton beam energy although beam intensity kept results also show temperature recirculation zone effectively limited adopting annulus shaped proton beam temperature distribution depends heat deposition velocity flow pattern results great value applied future design optimization ads windowless spallation target china elsevier ltd rights reserved
access digital data ability use integrated computational materials engineering framework critical needs materials manufacturing innovation since start materials genome initiative several efforts launched develop resources protocols necessary robust materials data infrastructure projects yielded promising results helping uncover clarify challenges remain asm international computational materials data network active several initiatives closely tracks others similar goals presentation reports status cmd network projects gives brief update many others also suggests ways consolidate efforts accelerate development infrastructure icme
accessible summary little known fathers think feel diagnosis autism fathers experienced strong emotion around diagnosis given little support services support mother fathers ways meet individual needs positive messages given families diagnosis abstractbackground diagnosis childhood autism extremely stressful experience parents little known concerning paternal perceptions process methods study investigated father perspectives diagnosis autism online survey results analysis replies open ended question identified following themes strong initial emotional response range immediate anxieties future struggle gain diagnosis anger response insensitive delivery diagnosis together insufficient information time lack support afterwards conclusion fathers experienced range significant challenges diagnostic process felt unsupported service provision gender differentiated taking account particular needs perspectives mothers fathers critical juncture family life
according deformable solid mechanics application set external actions body results modification state variables stress characterizes intensity internal forces point medium necessary know stress distribution quantifying resistant capacity solid calculation stresses applies supporting elements structure mechanical components machine respectively studied disciplines strength materials mechanical engineering work presented within context strength materials calculation stress distributions commonly used structural sections subjected bending means two virtual laboratories implemented purpose interest laboratories lies support provide teaching learning subject far allow calculate display distribution normal shear stresses according formulation explained lectures
according french standards constructed wetlands combined sewer overflow treatment cso cws vertical flow filters detention basin outflow rate limitation purpose treat rapid loads wastewater stochastic volumes concentrations periodicity first full scale cso monitored three years involving online equipment provided depth understanding hydraulics nitrogen dynamics saturation filter visualized along longitudinal section follow hydraulics filling tracer tests showed short circuiting effects adverse weaken process confirmed decreasing concentrations outflow short circuiting addressed minimizing filling time nitrogen dynamics adsorption capacities identical applied sand zeolite mixture pozzolana materials calculate inter event nitrification adsorbed masses equation fitted temperature mass measurements rate doubled every degrees finally nitrate found get washed low hydraulic loads median highlighting possibility developing second filter stage denitrification results helped calibrate design support software orage elsevier rights reserved
according one prominent false memory theories fuzzy trace theory false memories stem semantic association original information post event misinformation furthermore strength association predicts probability accepting post event misinformation original information order test prediction within eyewitness testimony framework current study used video mock theft narrative event original information changed post event misinformation end strong weak members category original information belongs semantically unrelated options given distractors addition original information recognition test analysis revealed semantically strong weak distractors significantly likely accepted original information semantically unrelated item semantically strong distractors accepted original information weak distractors although difference reach significance findings discussed terms fuzzy trace theory developmental reversals approach brainerd reyna
according sports injuries knowledge theory combine module theory internet technology designed sports injuries network consultation system paper makes explanation design ideas technology crucial module function design working example system system appraisal sports injuries give treating plan exercise rehabilitation prescription provide internet platform sports injuries treating counseling students teachers system important practice promotion values
according effective medium theory components microwave transparent concrete need low permittivity conductance screening related materials use appropriate production processes microwave transparent cement concrete samples manufactured microwave transmission ratios samples tested results indicate microwave transmission properties samples better ordinary concrete selecting raw material controlling moisture content keys
according national standard safety technology qualification automobile run computer control system automobile safe checking process designed gathers data stage meter exactly process store data computer display print result examination subject mainly emphasizes design system hardware mainly include develop set stable dependable analog signal processing circuit simulation
according tree structure description multibody system kane equations establish dynamic equations system proposed forms equations general simple moreover equations minimum dimension also convenient computer calculating parachute submunition system taken modelling object includes submunition plate parachute dynamic equations three parts established respectively dynamic kinematics equations whole system established influences drag coefficient crosswind velocity scan parameters simulated computer programming simulation results accordance flight principle exterior ballistic theory verifies reasonableness modelling method established dynamic equations
according world health organization mental distress related illnesses becoming leading causes morbidity mortality developing countries despite influence food insecurity mental health empirical understanding relationship sub saharan africa incidence food insecurity relatively high almost non existent study contributes literature examining association food insecurity mental health upper west region ghana used ordinary least square ols analyze cross sectional data collected household heads using household food insecurity access scale duke health profile results show heads severely food insecure beta moderately food secure households beta likely report elevated mental distress compared food secure households also found female household heads likely report elevated mental distress beta compared male counterparts findings suggest need improve food security strategy targeted improving overall mental health ghanaian context elsevier ltd rights reserved
accumulating evidence indicates long noncoding rnas lncrnas circular rnas circrnas involve germ cell development however little known functions mechanisms lncrnas circrnas self renewal differentiation germline stem cells therefore explored expression profiles mrnas lncrnas circrnas male female mouse germline stem cells high throughput sequencing identified novel lncrnas circrnas germline stem cells confirmed existence lncrnas circrnas pcr results showed male female germline stem cells similar gdnf signaling mechanism subsequently mrnas lncrnas circrnas exhibited sex biased expression may associated germline stem cell acquisition sex specific properties required differentiation gametes gene ontology kegg pathway enrichment analyses revealed different functions sex biased lncrnas circrnas constructed correlated expression networks including coding noncoding expression competing endogenous rnas bioinformatics expression analysis showed hundreds lncrnas correlated sex differences mouse germline stem cells including lncrna lncrna lncrna orik lncrna atpd cerna network inferred lncrna meg cirrna igfr could bind competitively mirna increasing target gene inha acsl kifb igfbp expressions findings provide novel perspectives lncrnas circrnas lay foundation future research regulating mechanisms lncrnas circrnas germline stem cells
accumulating evidence suggests varicocele long associated male infertility also risk factor low testosterone levels exact pathophysiology negative effects varicocele testicular function well understood theories include venous stasis increased testicular temperature oxidative stress resulting toxic environment prior studies report conflicting effects nonmicrosurgical varicocelectomy testosterone level recent literature demonstrates microsurgical varicocelectomy improves testosterone levels men varicocele low testosterone preoperatively
accumulation brain iron suggested biomarker neurodegeneration increased iron seen cerebral cortex postmortem studies neurodegenerative diseases healthy aging recently diminutive thickness cortex relatively low iron content hampered vivo study cortical iron accumulation using phase images weighted sequence ultrahigh field strength tesla examined iron content cortical regions healthy subjects aged years cortex automatically segmented parcellated phase shift analyzed using house developed method found significant increase phase shift age cortical regions concurrent current understanding cortical iron accumulation findings suggest increased cortical iron content assessed healthy aging vivo high spatial resolution sensitivity iron method make potentially useful tool studying cortical iron accumulation healthy aging neurodegenerative diseases elsevier inc rights reserved
accurate measuring systems thrive past years based laser scanners laser scanners able acquire information directly precisely real time however comparing conventional cameras kinds equipment usually expensive commonly available customers moreover laser scanners interfere easily sensors type hand computer vision based measuring techniques use stereo matching acquire cameras relative position estimate location points image kind systems needs additional estimation information systems real time capability often relies heavy parallelism prevents implementation mobile devices inspired structure motion systems propose system reconstructs sparse feature points point cloud using mono video sequence achieve higher computation efficiency system keeps tracking detected feature points calculates amount feature points moving distances use key frames estimate current position camera order reduce computation load noise interference system furthermore sake avoiding duplicate points system reconstructs point point shifts boundary camera experiments show system able implemented tablets achieve state art accuracy denser point cloud high speed
accurate control dissolved oxygen concentration crucial order use liquid lead alloys coolant advanced nuclear systems oxygen control system based pbo mass exchanger pbo technology implemented order control dissolved oxygen concentration liquid lead bismuth eutectic lbe loop mexico oxygen control system consisted packed bed pbo spheres oxygen sensor pneumatic control valve concentration dissolved oxygen loop controlled regulating lbe flow pbo using proportional integral derivative pid controller feedback oxygen sensor highly accurate control dissolved oxygen concentration loop achieved system
accurate pain assessment joint function judge perceiving correct valid cues pain targets displaying valid indicators pain present research examined whether judgeability pain expressions could altered manipulating nonverbal supportiveness videotaped physician guided targets experimentally induced pain experience laboratory ten video clips targets pain experience viewed judges assessed target pain point numeric rating scale addition video clips rated independent coders point scales focused calm tense distressed composed fidgety determined bored nervous judges pain assessment accuracy calculated correlating inferred pain rating target targets self reported pain pain targets assigned interact nonverbally supportive physician displayed valid impressions pain judges higher pain assessment accuracy viewing targets compared targets assigned interact nonverbally unsupportive physician interventions caregivers healthcare providers emphasize importance nonverbal behavior interacting pain sufferers discussed
accurate person perception crucial social decision making one central elements successful social perception ability understand another response bias behavior represent different inner states depending whether people yea sayers naysayers present study tried investigate internal biases others perceived using multi trial learning paradigm perceivers made predictions target responses various suggested activities received feedback prediction trial trial hypotheses internal decision criterion targets would realized repeated experiences due positive negative asymmetry yea sayers would recognized gradually naysayers probabilistic integration repeated experiences find neural evidence tracks probabilistic integration forming person knowledge response biases employed model based fmri state space model discovered person knowledge yea sayers modulated several brain regions including caudate nucleus dlpfc hippocampus etc moreover person knowledge updated incorrect performance feedback brain regions including caudate nucleus dlpfc dmpfc tpj also involved overlapping regions processes caudate nucleus dlpfc suggesting regions take crucial roles forming person knowledge repeated feedback reflecting acquired information current prediction elsevier inc rights reserved
accurate rainfall runoff modeling typhoon events essential task natural disaster reduction study novel hybrid model integrates outputs physically based hydrologic modeling system support vector machine developed predict hourly runoff discharges chishan creek basin southern taiwan seven storms total data sets used model calibration training validation six statistical indices mean absolute error root mean square error correlation coefficient error time peak discharge error peak discharge coefficient efficiency employed assess prediction performance overall superiority present approach especially longer lead time prediction revealed systematic comparison among three individual methods physically based hydrologic model artificial neural network support vector machine well two hybrid combinations besides analysis depth discussions clarify roles physically based data driven components proposed framework elsevier rights reserved
achieving complete mitral isthmus conduction block atrial fibrillation ablation remains challenging hypothesized transseptal puncture tsp anteroinferior aspect atrial septum anteroinferior tsp could shorten distance improve catheter contact stability enabling complete block study investigated efficacy anteroinferior tsp ablation patients three hundred twenty consecutive patients mean age years male persistent undergoing ablation including ablation enrolled ablation performed conventional posterior tsp site group anteroinferior tsp site group left atrial diameter lad enlargement greater group group complete block initial session significantly higher group group repeat session recurrence rate persistent complete block significantly higher group group lad left ventricular diastolic dimension significant predictors failed block anteroinferior tsp significantly associated successful block anteroinferior tsp could improve initial success rate long term persistence complete block ablation
acidic mammalian chitinase amcase implicated various pathophysiological conditions including asthma allergic inflammation food processing amcase active activity gradually decreases analyzed chitin degradation amcase weak acidic neutral conditions fluorophore assisted carbohydrate electrophoresis established originally oligosaccharides analysis found specific fragments slower expected mobility defined chitin oligosaccharide markers generated similar products reaction established improved method chitin oligosaccharides suppressing side reaction pre acidification fluorophore labeling reaction mixture improved method specifically detects chitin oligosaccharides warrants quantification nmol material using strategy found amcase produced dimer acetyl glucosamine gcnac strong acidic neutral condition moreover found amcase generates gicnac well gicnac physiological conditions authors published elsevier ltd
acne common skin condition sebum overproduction hyperkeratosis propionibacterium acnes acnes staphylococcus aureus inflammation punica granatum pomegranate well known anti inflammatory effects however studies discussed anti acne effects pomegranate study found pomegranate extract significantly reduced acnes induced edema inwistar rat ears therefore evaluation platform using multiple pathogenic mechanisms acne established explore anti acne effects pomegranate results showed inhibited bacterial growth lipase activity bioguided fractionation isolation system four hydrolysable tannins punicalagin punicalin strictinin granatin isolated compounds greater anti bacterial activities anti testosterone induced hacat proliferative effects others compounds displayed lipase inhibitory effects compound decreased cyclooxygenase expression downregulated prostaglandin production heat killed acnes treated raw cells conclusion abundant hydrolysable tannins display multiple anti acne capacities including anti bacterial anti lipase anti keratinocyte proliferation anti inflammatory actions hence great potential application anti acne skin care products punicalagin effective component employed quality control marker
acrodermatitis continua hallopeau ach variant pustular psoriasis often difficult treat almost anti psoriatic agents used treatment ach ustekinumab fully human monoclonal antibody igg class directed shared subunit cytokines herein present experience ustekinumab use year old man resistant anti tumor necrosis factor agents though initial therapy ustekinumab achieved sustained response patient seven months interruption retreatment resulted slower poorer response initial regimen responses patient reflects recalcitrant chronic nature ach patients value ustekinumab ach treatment iii fact biologics loss response may also occur ustekinumab treatment interrupted data provides evidence fact course ach unpredictable possibly indicate concerning current biologics used treatment ach still failed hit target aimed
acro osteolysis osteolysis distal phalanges hands feet affect terminal tuft shaft distal phalanx transverse band acro osteolysis often associated distal digital ischemia digital calcinosis severe sensory neuropathy acro osteolysis associated heterogeneous group disorders including occupational activities infections rheumatic disorders systemic sclerosis psoriatic arthritis endocrinopathies genetic disorders lysosomal storage disorders plain radiography gold standard detection acro osteolysis
activation casein kinase closely linked body disturbance carbohydrate metabolism inflammatory reaction renal chronic inflammatory reaction setting diabetes one important hallmarks diabetic renal fibrosis however remains unknown whether influences process diabetic renal fibrosis current study aimed investigate alpha ameliorates renal inflammatory fibrosis diabetes via kappa pathway explore potential regulatory mechanism alpha expression activity alpha studied plasmid transfection selective inhibitor small interfering rna sirna adenovirus infection vitro vivo analyzed means western blotting dual luciferase reporter assay electrophoretic mobility shift assay emsa following findings observed expression alpha upregulated kidneys kkay diabetic mice inhibition alpha kinase activity knockdown alpha protein expression suppressed high glucose induced expressions icam glomerular mesangial cells gmcs inhibition alpha kinase activity knockdown alpha protein expression restrained hcb degradation also suppressed induced nuclear accumulation transcriptional activity dna binding activity kappa gmcs treatment tbb alpha rnai adenovirus infection ameliorated renal fibrosis diabetic animals treatment tbb alpha rnai adenovirus infection suppressed hcb degradation kappa nuclear accumulation glomeruli diabetic animals study indicates essential role alpha regulating diabetic renal pathological process inflammatory fibrosis via kappa pathway inhibition alpha may serve promising therapeutic strategy diabetic nephropathy elsevier inc rights reserved
active demand side response dsr provide significant opportunity enhance power system flexibility great britain although electricity peak shaving clear reduction required investments power system benefits gas supply network examined using combined gas electricity networks expansion model cgen impact dsr electricity gas supply systems investigated time horizon results showed significant reduction capacity new gas fired power plants caused electricity peak shaving reduction gas fired power plants achieved dsr consequently reduced requirements gas import capacity million cubic meter per day cost savings resulted deployment dsr year time horizon estimated around billion power system although cost saving achieved gas network significant shown dsr crucial role play improvement security gas supply authors published elsevier ltd
active speakers traditionally identified video detecting moving lips paper demonstrates using spatio temporal features aim capture cues movement head upper body hands active speakers speaker directional information obtained using sound source localization microphone array used supervise training video features
active stealth warship important developing direction modern stealth technology field based scattering properties warship characteristics linear frequency modulated lfm signal matched filter cancellation signal designed warship stealth achieved interference cancellation cancellation signal radar echo signal simulation results show complete stealth warship achieved canceling lfm echo signal scattering field warship reduced almost even cancellation error proposed method provide important reference warship active stealth project realization
activity recognition fundamental many services envisaged pervasive computing ambient intelligence scenarios however delivering sufficiently robust activity recognition systems could deployed confidence arbitrary real world setting remains outstanding challenge developments wireless inexpensive unobtrusive sensing devices enabled capture large data volumes upon variety machine learning techniques applied order facilitate interpretation inference upon data much documented research area main focused recognition across pre segmented sensor data approaches insufficient near real time analysis required many services envisaged ambient assisted living paper presents novel near real time sensor segmentation approach incorporates notions sensor time correlation
actuators electric aircraft predominantly based permanent magnet machines best power weight ratio however permanent magnet machines give rise drag torque short circuit conditions paper explains concept permanent magnet assistance switched reluctance machines sets topology maximizes benefits permanent magnet assistance without compromising fault tolerance problem demagnetization topology explored revised design proposed increased torque permanent magnet assistance demonstrated laboratory tests prototype machine evidence fault tolerant nature proposed machine comparison baseline permanent magnet machine design suggested permanent magnet assisted segmental rotor switched reluctance machine could achieve similar torque permanent magnet machine application much improved fault tolerance much reduced magnet mass
acute chest wall infections uncommon share similar risk factors infection surgical sites smoking cessation shown decrease risk surgical site infection depending depth infection involvement organ space adequate therapy involves antibiotics drainage early diagnosis debridement necrotizing soft tissue infections essential reduce mortality sternoclavicular joint infections require surgical debridement bloc resection antibiotic therapy standard approach wound closure resection yet established vacuum assisted closure valuable adjunct standard therapy
acute lung injury ali early pathophysiologic change acute respiratory distress syndrome management challenging omalizumab xolair recombinant dna derived humanized antibody omz spt polypeptide heavy chain omalizumab monoclonal antibody found intramuscular administration omz spt significantly improved survival attenuated lung inflammation female cbl mice suffering lipopolysaccharide lps induced ali also demonstrated omz spt inhibit expression inflammatory cytokines tumor necrosis factor alpha interleukin beta interleukin elisa mice suffering lps induced ali mouse macrophage line raw cells addition showed omz spt inhibited lps induced activation nuclear factor kappa kappa signaling total expression kappa western blotting data suggest omz spt could novel therapeutic choice ali elsevier inc rights reserved
adapting application diverse dynamic domains required enlarge pervasive computing use satisfy people demand terms continuity services addition proliferation smart devices ubiquitous services motivate need quick development applications support people dynamic domains inappropriately quick development often associated discard domain knowledge therefore target research raising level adaptation rapid application development dynamic domains paper present work improve formal definition domain knowledge applications created domain experts propose context based semantic framework ami deu used create dynamic domain models basis building applications framework domain knowledge described means meaningful context include unambiguous terms operations resulting enhancement adaptation applications also present paper applicability framework describe dynamic domains context based services well develop micro context aware applications negotiate interchange context consume services multiple computational spaces
adaptive management well established approach managing natural resources little evidence demonstrating effectiveness adaptive management traditional management techniques peer reviewed literature attempts draw conclusions adaptive management effectiveness using social perceptions studies largely restricted employees federal organizations gain comprehensive insight perceived adaptive management effectiveness study aimed broaden suite disciplines professional affiliations geographic backgrounds represented practitioners scholars questionnaire contained series questions concerning factors lead inhibit effective management followed another set questions focused adaptive management using continuum representing strategies adaptive management traditional management respondents selected strategies perceived effective overall characteristics strategies stakeholders barriers identified respondents contributing effective management closely aligned adaptive management responses correlated type adaptive management experience rather individual discipline occupational regional affiliation particular perceptions characteristics contributing adaptive management effectiveness varied respondents identified adaptive management scholars implementation experience adaptive management practitioners together results supported two concepts make adaptive management effective practitioners emphasized adaptive management value long term approach scholars noted importance stakeholder involvement even communication practitioners scholars regarding adaptive management effectiveness could promote interdisciplinary learning problem solving improved resources management
adc dac radiation failures mainly due radiation induced degradation precision parameters transfer characteristic gain zero offset full scale voltage integral differential non linearity conversion error adc dac radiation failure specifics even slight deviation electrical parameter internal elements comparator threshold internal reference voltage switch leakage operational amplifier gain etc often leads significant degradation adc dac accuracy adc dac radiation test procedure facilities developed test results introduced
addressing documented shortage students united sates choosing enter computing engineering fields computing education academy cea established fairfield university expose high school students key computing concepts basic computer programming hands activities motivate students enter post secondary education career opportunities computing curriculum cea developed class modules combined lectures lab activities providing basic computing skill development first semester android app development second semester based survey results completion cea additional class modules combining arduino circuit design android app development components added first semester cea curriculum help students better prepared second semester survey results indicated obtaining higher levels understanding computing mobile development cea details cea curriculum evaluation results described future enhancement suggested
addressing global challenges water security requires better understanding humanity use water especially agricultural sector accounts global withdrawals study combined high resolution data gis system analyze impact agricultural practices crop type spatial factors drainage basins climate soil type water footprint agricultural crops area study northern lower jordan valley covers three main plantation crops grown banana cultivated open fields net houses avocado palm dates high resolution data sources included gis layers cultivated crops drainage pipe system installed study area meteorological data crop parameters yield irrigation recommendations first study compared different crops basis yield energy produced well comparison global values local irrigation recommendations results showed net house banana lowest based different criteria however palm dates showed highest yield criteria second lowest energy produced emphasizing importance using multiple parameters low high yield crop comparisons next regional drainage basin study area calculated demonstrating strong influence gray indication amount freshwater required pollution assimilation finally benefits integrating gis demonstrated computing effect adopting net house cultivation throughout area study result reduction mom irrigation water per year integrating methodology local high resolution data using gis therefore promote help quantify benefits adopting site appropriate crops agricultural practices lower increasing yield reducing water consumption minimizing negative environmental impacts
adhd symptoms run families however relatively little known ways parents symptoms might additively interactively work parenting environment influence influenced developmental trajectory symptoms children adolescents commentary special section addressing gap knowledge emphasis placed importance replicating extending family wide studies adhd symptoms etiology current papers exemplify leading edge efforts demonstrating feasibility rigor studies conducted utilizing longitudinal experimental designs families parenting environments operate system individuals influence symptoms functioning parents produce tremendous variability within well family individuals adhd symptoms childhood adulthood via gene environment transactions may even begin prenatal development
adhesive bonding offers simple efficient way joining structural components without weakening holes welding article develops new model predict fracture load bonded overlap joints using fracture mechanics approach bondline fracture resistance effects nonlinear inelastic behaviour structural adhesives accounted separately bonded single overlap joint configurations model expressed simple explicit formulas experimental programme presented design parameters designer adjust obtain desired joint capacity systematically varied comparison test results predictions current strength materials capacity models highlights disparities theoretical predictions experimental evidence contrast new model shows good agreement experimental results noted simple new formulas apply well defined range bonded overlap joint configurations purport apply general every joint configuration published elsevier ltd
adolescence period development begins puberty ends early adulthood commonly adolescence divided three developmental periods early adolescence years age late adolescence years age young adulthood years age adolescence marked physical sexual maturation social economic independence development identity acquisition skills needed carry adult relationships roles capacity abstract reasoning adolescence characterized rapid pace growth second infancy nutrition adolescent transition closely intertwined since eating patterns behaviors influenced many factors including peer influences parental modeling food availability food preferences cost convenience personal cultural beliefs mass media body image describe physiology metabolism nutritional requirements adolescents pregnant adolescents well nutrition related behavior current trends adolescent nutrition conclude thoughts implications nutrition interventions priority areas would require investigation
adolescents access use new media technology cell phone personal data assistant computer internet access rise explosion technology brings potential benefits risks attention growing risk adolescents become victims aggression perpetrated peers new technology september centers disease control prevention convened panel experts technology youth aggression examine specific risk special issue journal adolescent health presents data recommendations future directions discussed meeting articles journal support argument electronic aggression emerging public health problem need additional prevalence etiological research support development evaluation effective prevention programs society adolescent medicine rights reserved
adolescents particularly prone peer influence since group membership modulates person tendency take someone else viewpoint decided investigate whether adolescents influenced presence peer taking another person perspective group adolescents upper secondary schools naples italy observe scenes actor adolescent adult gazing grasping gazing grasping object staying still required judge spatial location object adolescent participants adopted actor viewpoint third person perspective frequently actor adolescent rather adult adolescent actor grasped object thus adolescents seem particularly prone mentally simulate someone else actions person peer findings suggest modulating motor simulation processes via social environmental factors could influence adolescents perspective taking foundation professionals services adolescents published elsevier ltd rights reserved
adolescents hong kong become liberal receptive towards sex recent decades research findings indicated increase rate premarital sex among hong kong adolescents also held permissive attitude towards premarital sex past sex education however always well organised delivered schools recent survey indicated hong kong teachers found well equipped teach sex education lacked relevant learning teaching resources current educational resources sex education mainly designed used classroom typically composed presentation slides lesson plans group based activities discussion sex still taboo chinese society self learning resources supplement classroom teaching unfortunately rarely offered online tailored mobile access available online resources mostly text based unattractive vulnerable adolescent group project aims address gap developing interactive game playable facebook ipad web educate equip young adolescents reliable knowledge positive attitudes towards sex relationship life skills necessary making wise decisions regarding love sex fun way game titled making smart choices consists five mini games adopting chinese user interface offering different scenarios players exact decisions chosen virtual characters learn process mini games aim help young adolescents gain better self understanding establishing healthy love relationship learn set maintain intimate boundaries understand sexual impulse considerations deciding whether sex acquire safer sex knowledge including awareness selfprotection contraceptives prevention sexually transmissible diseases emergency contraception aware available options support services case unplanned pregnancies evaluate effectiveness acceptance game among young adolescents series workshops game sessions conducted junior students secondary secondary six secondary schools students knowledge safer sex collected playing game participants also asked complete questionnaire regarding perception value game whether found game interesting user friendly focus group interviews arranged selected students order gather detailed feedback collected data analysed using spss results showed playing game students sex knowledge improved high medium effect size improvement found every junior secondary level survey respondents perceived game helped enhance critical thinking decision making ability seek help regarding matters related love sexuality addition knowledge proper attitudes towards relationship sex mostly receptive game finding fun play describing content interesting interactive informative close reality applicable
adolescents without autism spectrum disorder asd performed two priming experiments implicitly processed prime stimulus containing high low spatial frequency information explicitly categorized target face either male female gender task positive negative valence task adolescents asd made categorization errors typically developing adolescents also showed age dependent improvement categorization speed difficulties categorizing facial expressions gender however neither categorization tasks found group differences processing coarse versus fine prime information contradicted expectations indicated perceptual differences adolescents without asd critically depended processing time available primes
adsorption based cooling systems becoming increasingly popular due continuous rise worldwide demand refrigeration air conditioning study aims enhance cooling performance solar powered adsorption chiller using novel multi walled carbon nanotube mwcnt mil composite adsorbent numerically validated modeling approach employed evaluate coefficient performance cop specific cooling power scp two bed adsorption chiller solar energy input flat plate solar collector employed three different configurations glaze single glazed cover double glazed cover single glazed cover transparent insulation material observed mwcnt mil composite adsorbent containing mwcnts results maximum achievable cooling power wkri adsorption chiller proposed mwcnt mil composite adsorbent considered successful potential replacement traditionally used silica gel zeolite based adsorbents use next generation high performance solar adsorption chillers elsevier ltd rights reserved
adtpp open source tool adds support algebraic data types adts programming language adts allow precise description program types robust handling data structures directly supported adt definitions declarations put file preprocessed adtpp produce header file included source files generated header file contains type definitions macros inline functions support type safe construction deconstruction pattern matching adt values avoiding unsafe operations casts avoiding risk errors dereferencing null pointers accessing inappropriate fields unions values represented efficiently using techniques implementation declarative languages many simple data types memory representation identical direct implementation loss efficiency complex types adtpp representation efficient common representations preserving type safety convenience example present new variation trees compact adtpp also supports parametric polymorphism defining type list adt generic functions length however polymorphic code somewhat verbose typical declarative languages due reliance limited type checking available copyright john wiley sons ltd
adult mice leydig cell specific deletion mapk kinase mek mek mek cre mice display leydig cell hypoplasia hypergonadotropic hypogonadism used radioimmunoassays quantitative pcr evaluate function expression leydig cell genes involved conversion cholesterol testosterone star cypa hsdb cypa hsdb androgen metabolism srda dhrs four transcription factors creb nra nra nrb regulate expression steroidogenic genes show star hsdb cypa hsdb downregulated ledyig cells adult mek mek cre mice whereas srda dhrs upregulated creb nra nra nrb unchanged upregulated functionally downregulated genes none upregulated genes contribute decrease testosterone synthesis leydig cells adult mek mek cre mice produce low testosterone dihydrotestosterone stimulated hcg incubated testosterone precursors progesterone androstenedione elsevier ireland ltd rights reserved
advanced biomedical instruments data acquisition techniques generate large amount physiological data accurate diagnosis related pathology become necessary develop new methods analyzing understanding data clinical decision support systems designed provide real time guidance healthcare experts evolving alternate strategy increase exactness diagnostic testing generalization ability systems governed characteristics dataset used development observed sub pathologies much varied ratio occurrence population making dataset extremely imbalanced problem resolved levels data level well algorithmic level work proposes synthetic sampling technique balance dataset along modified particle swarm optimization pso technique comparative study multiclass support vector machine svm classifier optimization algorithm based grid selection gsvm hybrid feature selection svmfs genetic algorithm pso presented work empirical analysis five machine learning algorithms demonstrate pso statistically outperforms others elsevier inc rights reserved
advanced jet engines operate application vacuum optimal use advanced military applications drives much basic innovative research development especially new needs arise rapidly changing domains stealth agile fighter aircraft tailless stealth jet steered unmanned air vehicles uav reasons periodically update journal new trends affect sometimes control research development future jet engines one relevant example recently unmasked stealth tailless drone improved version smaller captured iran important new tailless stealth uav dominate future uses fuel efficient jet engines especially operating dusty environments secretly designed funded since based classified parent israeli patents protect hundreds design testing trade secrets taken united states government usg via classified contracts usg contractors boeing lockheed general dynamics general electric revealed december aviation week court appeals federal circuit case docket new design explains recent air force isr shift away permissive environments iraq afghanistan non stealthy global hawk general atomics reaper operate toward new missions highly contested strongly denied enemy airspaces
advanced photovoltaic devices high performance cost ratio major concern nowadays present study investigate energetic efficiency new concept based indirect instead direct photovoltaic thermoelectric coupling using state art thermal transfer calculations shown indirect coupling interesting alternative maximize solar energy exploitation model concentrator placed photovoltaic thermoelectric systems without physical contact three components major finding showed indirect coupling significantly improve overall efficiency promising future photovoltaic developments elsevier ltd rights reserved
advanced science technology based carbon based nanomaterials experiencing rapid rate change performance capabilities substitute serve alternative approaches existing technologies one major environmental concerns water pollution heavy metals heavy metals water main preoccupation many years toxicity towards aquatic life human beings also environment context water wastewater treatment significant numbers breakthroughs achieved drive accelerated change ceaseless capability improvements contribution unique features promising carbon based nanomaterials generated tremendous interest among material researchers described along potential applications water wastewater treatment carbon based nanomaterials stand one highly efficient nanomaterials due vast availability lower production cost compared nanomaterials paper critically reviewed application different type carbon based nanomaterials water wastewater treatment carbon nanomaterials role adsorption disinfection membrane separation mechanisms enable applications discussed advantages limitations well barriers research needs highlighted challenges include technical hurdles high cost environmental health risk taiwan institute chemical engineers published elsevier rights reserved
advancements microelectronics software allow use embedded systems implementation control laws work stm microcontroller exploited order implement robust fixed low order controller electronic system parametric uncertainty model employed describe system behavior controller objective guarantee time response specifications presence model uncertainties controller design expressed min max non convex optimization problem taking account desired closed loop performances uncertainties accordingly aim obtaining optimal solution optimal control law application global optimization method recommended work exploited global optimization method generalized geometric programming implementation proportional integral controller proportional integral derivative controller fixed low order controller shows efficiency latter one
advances artificial intelligence computer graphics digital technologies contributed relative increase realism virtual characters preserving virtual characters communicative realism particular joined ranks improvements natural language technology animation algorithms paper focuses culturally relevant paralinguistic cues nonverbal communication model effects englishspeaking digital character different accents human interactants users cultural influence model proposes paralinguistic realism form accented speech effective promoting culturally congruent cognition self relevant users example chinese middle eastern english accent may perceived foreign individuals share ethnic cultural background members cultures however individuals familiar affiliate cultures group members bicultural accent serves motif shared social identity also primes adopt culturally appropriate interpretive frames influence decision making
advances computing technology computer graphics engulfed huge collections data introduced new visualization techniques gives users many choices visualization techniques gain insight dataset hand however selecting suitable visualization given dataset task performed data subjective work presented introduces set visualization metrics quantify visualization techniques based comprehensive literature survey propose effectiveness expressiveness readability interactivity visualization metrics using metrics framework optimizing layout visualization technique also presented framework based evolutionary algorithm uses treemaps case study starts randomly initialized population chromosome population represents one complete treemap using genetic operators proposed visualization metrics objective function finds optimum visualization layout visualizations evolved compared state art treemap visualization tool user study user study utilizes benchmark tasks evaluation comparison also performed using direct assessment internal external visualization metrics used results verified using analysis variance anova test results suggest better performance proposed metrics based framework optimizing visualization layout proposed methodology also extended visualization techniques elsevier inc rights reserved
advances energy harvesting systems needed power wireless sensors structural health monitoring research developing harvesting system converts low frequency non periodic low acceleration vibrations present bridges continued significantly extended work mechanics harvester optimized increase robustness lifetime power electronics added complete system installed new carquinez suspension bridge california complete results analysis presented study power management circuit added rectify boost low output harvester convert usable voltage harvester design enhanced significantly improve performance robustness short term bridge testing system able charge capacitor average harvester output power ranges depending location bridge improvement previous results long term test harvesting system conducted performance system monitored remotely using wireless sensor network system improvements described study enabled continuous operation harsh bridge environment months starting april constitute major milestone development miniaturized motion harvesters finally system retrieved analyzed understand verify cause observed long term performance changes elsevier rights reserved
advances laboratory information technologies transforming public health microbiology high throughput genome sequencing bioinformatics enhancing ability investigate control outbreaks detect emerging infectious diseases develop vaccines combat antimicrobial resistance increased accuracy timeliness efficiency advanced molecular detection amd initiative allowed centers disease control prevention cdc provide leadership coordination integrating new technologies routine practice throughout public health laboratory system collaboration partnerships key navigating transition leveraging next generation methods tools effectively public health
advances nano electronics vlsi manufacturing technology rapid downscaling size logic circuits made prone errors led need fast circuit reliability evaluation large logic circuits paper new method reliability analysis vlsi logic circuits based modified form mason rule proposed utilizing matrix sparsity significantly increases speed reduces required memory proposed approach addition approach introduced mitigate effect reconvergent paths simulation results indicate proposed method scalable runs faster previously proposed schemes published elsevier ltd
adverse childhood experiences aces linked increased use tobacco products later life however studies date ignored smokeless tobacco products address data behavioral risk factor surveillance system interviewed adults years analyzed logistic regression models fit estimate odds ratios ever smoking current smoking current smokeless tobacco use relation aces results showed less respondents currently used smokeless tobacco products reported ever current smoking respectively physical abuse emotional abuse sexual abuse living drug user living someone jailed parents separated divorced associated smokeless tobacco use unadjusted models accounting confounders physical abuse emotional abuse living problem drinker living drug user living adults treated violently associated smokeless tobacco use living someone mentally ill associated smokeless tobacco use accounting confounders aces results indicated childhood adversities associated use smokeless tobacco products special attention needed prevent tobacco use different types among experiencing aces
adverse childhood experiences associated higher risk suicide suicidal behavior later life known associations childhood trauma particularly sexual abuse higher rates suicide non lethal suicide attempts non suicidal self injurious behaviors adolescence adulthood emotional abuse neglect disrupted parental attachment cumulative effect multiple forms maltreatment also increase risk yet causal relationship remains unclear diathesis stress model provides framework understanding early life adverse experiences contribute suicide vulnerability current findings fields biology neurology genetics shed new light mediating variables possible causal links early childhood trauma suicide paper review recent advances particularly regarding interaction early life environmental adverse events genetics factors increase diathesis psychological traits associated subsequent deliberate self harm behaviors
adverse parenting associated increased risk development mood behavioral disorders study assessed perceived parental bonding medical students using parental bonding instrument pbi extracted students reported parents rearing attitudes affectionless control low low care high overprotection using item general health questionnaire zung self rating depression scale zung sds hospital anxiety depression scale hads spielberger state trait anxiety inventory stai physical mental state low students compared students reported parental bonding optimal opt high care low overprotection questionnaire measurements demonstrated significantly higher anxiety depressive mood low students versus opt students compared opt students low students also exhibited significantly reduced salivary cortisol awakening response car without changes across rest diurnal salivary cortisol profile among glucocorticoid related genes examined adrb ilr ilrn mcr tgfb tgfb faslg real time reverse transcription pcr showed low students significantly increased expression dominant negative glucocorticoid receptor mrna decreased adrenergic receptor adrb mrna levels circulating leukocytes results suggest negative perception parents child rearing attitudes may associated anxiety depressive mood altered glucocorticoid signaling even healthy young adults
adverse social conditions early life linked increased expression proinflammatory genes reduced expression antiviral genes circulating immune cells conserved transcriptional response adversity ctra however remains unclear whether effects specific western educated industrialized rich democratic weird cultural environments previous research conducted assess roles early adversity individual psychological resilience immune system gene regulation within non weird population evaluated ctra gene expression profiles former child soldiers matched noncombatant civilians people war nepal ctra gene expression regulated former child soldiers effects linked degree experienced trauma associated distress posttraumatic stress disorder ptsd severity child soldier status per self perceived psychological resilience associated marked buffering ctra activation ptsd affected former child soldiers high levels personal resilience showed molecular profiles comparable ptsd free civilians results suggest ctra responses early life adversity restricted weird cultural contexts underscore key role resilience determining molecular impact adverse environments
aerial gamma ray surveys important tool national security scientific arid industrial interests determining locations anthropogenic natural sources radioactivity relationship radioactivity geology past relationship used predict geology aerial survey purpose project develop method predict radiologic exposure rate geologic materials creating high resolution background model intention method used emergency response scenario background radiation environment unknown two study areas southern nevada modeled using geologic data images advanced spaceborne thermal emission reflection radiometer aster geochemical data pre existing low resolution aerial surveys national uranium resource evaluation nure survey using data geospatial areas homogenous terms referred background radiation units defined gamma ray exposure rate predicted prediction compared data collected via detailed aerial survey department energy remote sensing lab nellis allowing refinement technique using geologic units define radiation background units exposed bedrock aster visualizations subdivide define radiation background units within alluvium successful models produced government wash north lake mead western shore lake mohave east searchlight authors published elsevier ltd
affective disorders major depression bipolar disorder seasonal affective disorder associated major disruptions circadian rhythms indeed altered sleep wake cycles critical feature diagnosis dsm several therapies used treat disorders profound effects rhythm length stabilization human populations furthermore multiple human genetic studies identified polymorphisms specific circadian genes associated disorders thus appears strong association circadian system mood regulation although mechanisms underlie association unclear recently number studies animal models begun shed light complex interactions circadian genes mood related neurotransmitter systems effects light manipulation brain circuitry impact chronic stress rhythms ways antidepressant mood stabilizing drugs alter clock review focus recent advances gleaned use pre clinical models understanding circadian system regulates mood elsevier ecnp rights reserved
intense scientific exploration decade failed trials alzheimer disease remains fatal global epidemic traditional research drug development paradigm continues target heterogeneous late stage clinically phenotyped patients single magic bullet drugs propose time paradigm shift towards implementation precision medicine enhanced risk screening detection treatment prevention overarching structure achieved provided convergence breakthrough technological advances including big data science systems biology genomic sequencing blood based biomarkers integrated disease modeling medicine hypothesized deconstructing multiple genetic biological subsets existing within heterogeneous target population provide effective strategy treating individual patients specific agent likely work best based specific individual biological make alzheimer precision medicine initiative apmi international collaboration leading interdisciplinary clinicians scientists devoted towards implementation neurology psychiatry neuroscience hypothesized successful realization neurodegenerative diseases result breakthrough therapies oncology optimized safety profiles better responder rates treatment responses particularly biomarker guided early preclinical disease stage clinical trials
introducing main principles transitive closure graphs paper discusses application modified floyd warshall algorithm calculate network time models projects concern whether graph one starting ending node whether includes logical loop whether connected model whether necessitates positive lower bound negative upper bound multiple restrictions amongst time data project elements schedule open networks method may contribute generalization network time models especially considered multi project management context authors published elsevier ltd
recent improvements described open source finite element software elmer shown highly efficient option electrical machine modeling parallelization computational burden shown necessity methods implemented enable applying fully parallel computation electrical machine models including rotation electrical circuits computational experiments performed demonstrate elmer effectively utilize several hundreds computational cores parallel making attractive alternative computational speed high importance
large hadron collider turned new energetic machine needed order explore unknown regions high energy physics reason project future circular collider fcc started goal developing circumference collider tev proton beams eurocircol collaboration part fccstudy european community leadership aims develop conceptual design fcc till one main targets design bending dipole able reach operation magnetic field order accomplish size energy constraints magnetic field reached using nbsn conductors one option exploration cos dipole infn milano genova high stored energy large current densities due conductor performances quench protection one challenging aspects design paper quench protection cos design presented standard quench protection study accompanied less conservative study includes effects power dissipation inside coils magnet inductance order exclude preventively convenient designs develop performing magnet possible
decade research web application security continues challenge backend database appetizing target paper proposes preventing injection attacks database management system dbms behind web applications embedding protections dbms motivation twofold first approach embedding protections operating systems applications running top effective protect applications second semantic mismatch sql queries believed executed dbms actually executed leading subtle vulnerabilities protection mechanisms approach septic implemented mysql evaluated experimentally web applications written php java spring evaluation septic shown neither false negatives false positives contrary alternative approaches causing also low performance overhead order
agarwood formation aquilaria malaccensis could artificially stimulated fungal infection furthermore malaccensis adapts infection developing typical included phloem boundary within xylem tissues naturally synthesized agarwood requires lengthy process years impedes continuous production therefore recent effort allocated elucidation agarwood formation stimulate process rapidly study artificially induced agarwood formation injection inoculation cultivated aquilaria malaccensis four strains fusarium solani isolated different places indonesia results showed malaccensis responded differently upon wounding fungal inoculations compared healthy trees wounded inoculated samples resulted formation typical discoloration zone surrounding injection sites anatomical observation revealed samples also developed included phloem structures resinous agarwood compounds accumulated gas chromatography mass spectrometry analysis inoculated samples yielded important agarwood compounds tridecanoic acid alpha santalol spathulenol present healthy controls wounded samples notably one tested solani strain gorontalo displayed promising results candidate artificially induced agarwood formation malaccensis terms color odor chemical constituents
age menopause related impairment working memory mediated dorsolateral prefrontal cortex dlpfc occurs humans nonhuman primates long term cyclic beta estradiol treatment rescues cognitive deficits aged ovariectomized rhesus monkeys restoring highly plastic synapses tested whether distributions protein coupled estrogen receptor gper within monkey layer iii dlpfc synapses sensitive age estradiol coupled cognitive function ovariectomized young aged monkeys administered vehicle estradiol first tested delayed response test working memory quantitative serial section immunoelectron microscopy used determine distributions synaptic gper gper containing nonperforated axospinous synapse density reduced age partially restored estrogen treatment majority synapses expressed gper predominately localized presynaptic cytoplasm mitochondria gper also abundant plasmalemmas within cytoplasmic postsynaptic density psd domains dendritic spines gper levels differ age treatment none variables examined tightly associated cognitive function however greater representation gper subjacent psd accompanied higher synapse density data suggest gper positioned support diverse functions key synaptic plasticity monkey dlpfc
ageing central nervous system cns major risk factor alzheimer disease type neurodegeneration associated deficits cognition memory clinically manifested severe senile dementia numerous mental processes underline cognition including attention producing understanding language learning reasoning problem solving decision making memory formation past neurones parts considered exclusive cellular sites memory cognitive processes however become evident astrocytes major homeostatic glial cell cns provide essential contribution memory formation astroglial failure may promote cognitive decline response network reset mechanisms mediated noradrenergic projections neurones located locus coeruleus astrocytes get excited participate morphological remodelling associated synaptic plasticity otherwise thought represent cellular mechanism learning memory astroglial morphological plasticity energy demanding process requiring mobilisation glycogen cns almost exclusively stored astrocytes astroglia exhibit cytoplasmic excitability engages ions second messengers camp ions molecules contribute reception extracellular signals coordinate secretion glio signalling molecules including peptides apolipoporotein participates lipid transport glia neurones setting astrocytes positioned spatio temporal integrators neural network coordination disintegrates progression elsevier rights reserved
agent based modelling simulation promising methodology applied study population dynamics main advantage technique allows representing particularities individuals modeled along interactions take place among environment hence classical numerical simulation approaches less adequate reproducing complex dynamics nowadays rise interest using distributed computing perform large scale simulation social systems however inherent complexity type applications challenging requires study possible solutions parallel computing perspective deal fine grain irregular workload paper discuss particularities simulating populating dynamics using parallel discrete event simulation methodologies illustrate approach present possible solution make transparent use parallel simulation modeling demographic systems yades tool yades modelers easily define models describe different demographic processes web user interface transparently run computer architecture environment thanks demographic simulation library code generator therefore transparency provided two means provision web user interface modelers policy makers specify agent based models tools familiar automatic generation simulation code executed platform cluster supercomputer study conducted evaluate performance solution high performance computing environment main benefit outline findings generalized problems similar characteristics demographic simulation model elsevier rights reserved
aggregation neurotoxicity amyloid beta beta protein hallmark characteristic alzheimer disease study compared anti aggregatory neuroprotective effects five synthetic compounds beta protein four possessed five membered heterocycle ring scaffold two dibenzyl phenyl imidazolidines two triazole sulfanyl acetamides one fused five membered heterocycle benzoxazole ring selected thorough virtual screening zinc database molecular docking optimized structures used study beta binding characteristics predicted molecular docking strong steric binding imidazolidines bonding triazoles beta translated anti beta aggregation properties subsequent transmission electron microscopy tem used assess effects beta fibril formation four compounds variably altered morphology fibrils long intertwined fibrils short loose structures thioflavin assay beta fibrillisation kinetics demonstrated one imidazolidine triazole compounds inhibited beta aggregation rat pheochromocytoma cells exposed beta alone combination heterocyclic compounds assess neuroprotective effects beta evoked loss neuronal cell viability significantly attenuated presence imidazolidine compounds triazole acetamides benzoxazole compound toxic cells findings highlight beta anti aggregative neuroprotective propensity dibenzyl phenyl imidazolidine scaffold compound triazole sulfanyl acetamide scaffold also possessed beta anti aggregation properties also demonstrated significant intrinsic neurotoxicity overall predictive efficacy silico methods enables identification novel imidazolidines act inhibitors beta aggregation neurotoxicity may provide platform development novel alzheimer diseasemodifying pharmacotherapies crown copyright published elsevier masson sas rights reserved
aggressive behavior genetic environmental components many association studies performed identify genetic factors underlying aggressive behaviors humans review summarize previous work performed field considering candidate gene cgas genome wide association studies gwas excluding performed samples primary diagnosis psychiatric neurological disorder aggression related phenotype subsequently studied enrichment pathways functions gwas data results searches show cgas identified associations genes involved dopaminergic serotonergic neurotransmission hormone regulation hand gwas yet identified genome wide significant associations top nominal findings related several signaling pathways axon guidance estrogen receptor signaling also neurodevelopmental processes synaptic plasticity future studies use larger samples homogeneous phenotypes standardized measurements identify genes underlie aggressive behaviors humans wiley periodicals inc
aggressive behavior one themost challenging symptomsin psychiatry biological markers aggression lack large sample validations serotonin neuroactive compounds deriving tryptophan trp including kynurenine kyn yet investigated large cohorts aggressive individuals validate potential biomarkers aggression male inmates measured serum levels trp hydroxytryptophan kyn ratios trp kyn trp performed structured clinical interview dsm axis disorders scid global assessment functioning gaf scales aggressive behavior impulsivity adult attention deficit hyperactivity disorder adhd intelligent quotient aggressive compared non aggressive inmates exhibited lower trp kyn serum levels higher levels trp higher levels impulsivity adhd indices lower gaf higher prevalence mood disorders drug abuse dependence borderline conduct antisocial behaviors interestingly kyn trp positively correlated number severe aggressive acts adjusting confounding factors logistic regression analysis indicated trp antisocial behavior gaf predictors aggressive behavior model combining three predictors area roc curve study indicates circulating trp reduced aggressive individuals combination biological trp ratio psychopathological antisocial behavior gaf markers discriminates aggressive non aggressive behavior suggesting potential multi marker approach psychiatry given heterogenic nature mental diseases elsevier inc rights reserved
aging accompanied general decline physiological functions body deteriorating organ systems brain exception deficits cognitive functions quite common advanced aging though variety age related alterations observed structure function throughout brain certain regions show selective vulnerability medial temporal lobe especially hippocampus one preferentially vulnerable region crucial structure involved learning long term memory functions hippocampal synaptic plasticity long term potentiation ltp depression ltd candidate cellular correlates learning memory alterations properties well documented aging related phenomenon called synaptic tagging capture stc proposed mechanism cellular memory consolidation account temporal association memories mounting evidences behavioral settings suggest stc could physiological phenomenon article review recent data concerning stc provide framework alterations stc related mechanisms could contribute age associated memory impairments enormity impairment learning memory functions demands understanding age associated memory deficits fundamental level given impact everyday tasks thereby quality life understanding also crucial designing interventions preventive measures successful brain aging national university singapore published elsevier
agreement client therapist essential part therapeutic alliance general challenges creation agreement shared meaning psychotherapies specific challenges working persons psychosis challenges include different narratives client therapist regard roles description condition problem well possible stigmatic views theoretical bias present metacognitive intersubjective model framework understanding resolutions challenges copyright john wiley sons ltd
agricultural diffuse water pollution remains notable global pressure water quality posing risks aquatic ecosystems human health water resources result legislation introduced many parts world protect water bodies due efficiency cost effectiveness water quality models increasingly applied catchments decision support tools dsts identify mitigation options introduced reduce agricultural diffuse water pollution improve water quality study soil water assessment tool swat applied river wensum catchment eastern england aim quantifying long term impacts potential changes agricultural management practices river water quality calibration validation successfully performed daily time step observations discharge nitrate total phosphorus obtained high frequency water quality monitoring within blackwater sub catchment covering area variety mitigation options identified modelled singly combination long term effects nitrate total phosphorus losses quantified together uncertainty range model predictions results showed introducing red clover cover crop crop rotation scheme applied within catchment reduced nitrate losses buffer strips width represented effective options reduce total phosphorus losses achieving reductions respectively one first studies quantify impacts agricultural mitigation options long term water quality nitrate total phosphorus daily resolution addition providing estimate uncertainties impacts results highlighted need consider multiple pollutants degree uncertainty associated model predictions risk unintended pollutant impacts evaluating effectiveness mitigation options showed high frequency water quality datasets applied robustly calibrate water quality models creating dsts effective reliable authors published elsevier ltd open access article license http creativecommons org licenses
aim netherlands preventive child healthcare workers pchws important role identifying signs abuse reach virtually children closer cooperation pchws forensic physicians could improve detection child abuse aim study evaluate use forensic expertise pchws subjects methods november survey distributed among pchws employed amsterdam public health service results forty nine percent pchws indicated suspicions physical abuse last months response rate rated consultation forensic physicians useful year period three respondents sought advice forensic doctor conclusions although pchws regularly suspicions physical child abuse positive attitude towards consulting forensic physician consultation rates low research needed understand barriers consultation forensic physicians
aim limited data exist crohn disease associated small bowel adenocarcinoma sba large scale retrospective cohort study conducted comparing clinical features outcome associated sba novo sba method data patients small bowel adenocarcinoma gathered united states surveillance epidemiology end results cancer registry medicare linked database identified patients associated novo sba main outcome measures overall survival cancer specific survival css results associated sba commonly located ileum patients diagnosed earlier stage compared novo sba likely undergo surgery chemotherapy use similar patients associated sba better year similar css difference cohorts stratified stage multivariate analysis significantly related hazard ratio surgery extent lymphadenectomy improved sba patients whereas chemotherapy conclusion patients associated sba present earlier stage patients novo sba receive surgery similar rates chemotherapy similar css presence worsen survival treatment sba
aim purpose trial compare effectiveness sacral neuromodulation snm submucosal injection collagen permacol women faecal incontinence following obstetric anal sphincter injury oasis method single blinded randomized controlled trial two hospital units norway included women faecal incontinence following oasis eligible women successful percutaneous nerve evaluation randomly assigned snm permacol primary outcome difference mark incontinence score baseline months secondary outcomes changes disease specific quality life fiql urinary incontinence iciq scores results fifty eight women randomly assigned snm permacol reduction mark score baseline months snm group permacol group resulting difference differences four scales fiql lifestyle coping depression embarrassment respectively favour snm difference iciq favour snm nine minor adverse events snm group compared seven permacol group conclusion snm superior permacol terms reduction mark score iciq change fiql women faecal incontinence following oasis
aim risks fasting ramadan patients adrenal insufficiency unknown aims study evaluate risks patients determine risk factors finally set recommendations methods cross sectional study patients known treated adrenal insufficiency patients responded item questionnaire concerning knowledge disease fasting last month ramadan results women men mean age years one hundred thirty eight patients advised physician fast ninety one patients tried fast complications occurred cases asthenia cases intense thirst symptoms dehydration symptoms hypoglycaemia one patient hospitalized fifty five patients able fast whole month age gender duration disease primary origin associated hypothyroidism diabetes mellitus hypertension diabetes insipidus daily dose hydrocortisone significantly differ fasters non fasters full month fasters partial month fasters fasters complications fasters without complications frequency adequate knowledge disease significantly higher full month fasters partial month fasters fasters without complications complications conclusion patients adrenal insufficiency fasting cause complications especially level knowledge disease low
aim retrospective cohort study analyzes impact possible risk factors survival chance patients cryptococcal meningitis factors include patient socio economic background age gender presenting symptoms comorbidities laboratory findings particular non adherence versus adherence therapy methods data collected adult patients admitted kalafong hospital laboratory confirmed cryptococcal meningitis period months analyzed data presentation descriptive summary statistics logistic regression used assess factors showed association outcome measure factor furthermore multivariable logistic regression analysis using factors showed significant association cross tabulation applied determine factors impact patients mortality risk results total patients identified except one hiv positive antiretroviral therapy naive history previous tuberculosis given patients tuberculosis treatment admission started hospital stay hospital mortality statistical analysis showed antiretroviral therapy naive patients times greater odds dying compared antiretroviral therapy patients dying compared patients treatment defaulters times greater odds dying patients dying compared non defaulters addition patients presented nausea vomiting times greater odds dying remained significant adjusted antiretroviral therapy naive patients defaulters conclusion cryptococcal meningitis still common opportunistic infection people living hiv aids resulting hospitalization high mortality defaulting antiretroviral therapy presentation nausea vomiting associated significantly increased mortality risk
aim assess safety efficacy percutaneous radiofrequency thermal ablation rfa treatment nonsurgical hepatocellular carcinoma hcc daily practice methods total consecutive patients hcc solitary nodule nodules cirrhosis treated rfa majority patients compensated liver disease child early tumor stage clip indications treatment primary hcc therapy patients adjuvant therapy liver transplantation patients palliation remaining patients progression hcc despite previous antitumoral treatments rfa performed electrical generator connected expandable hook electrode results seventy one lesions treated sessions sixteen patients required adjuvant chemoembolization mean follow months objective response achieved patients underwent primary adjuvant treatment complete histological necrosis found patients underwent liver transplantation one year survival rates respectively patients underwent primary adjuvant therapy respectively patients underwent palliative therapy major complications hemoperitoneum pleuritis pneumothorax sepsis observed patients notably rapid neoplastic progression observed two patients within months single rfa session neoplastic portal thrombosis plurifocal hcc one patient cutaneous seeding lung metastases another patient conclusions majority hcc patients treated percutaneous rfa achieve local control tumor hccs less equal procedure associated major complications cases rapid neoplastic dissemination may occur accurate selection candidates rfa treatment advisable
aim compare impact laparoscopic roux gastric bypass lrygb laparoscopic sleeve gastrectomy lsg weight loss obesity related comorbidities two year follow via case control study design methods forty patients undergoing lrygb completed two year follow matched patients undergoing lsg age gender body mass index presence type diabetes mellitus tdm data patients retrospectively reviewed compare outcome terms weight loss improvement comorbidities tdm hypertension htn obstructive sleep apnea syndrome osas hypothyroidism gastroesophageal reflux disease gerd results percentage excess weight loss ewl similar lrygb lsg groups one year follow significantly greater lrygb group two years compared lsg group complication rate lrygb lsg similar median duration tdm mean number oral hypoglycemic agents higher lrygb group lsg group years years respectively lrygb lsg significant similar improvement tdm htn osas hypothyroidism however gerd resolved patients undergoing lrygb resolved cases lsg eight point three percent patients developed new onset gerd lsg conclusion lrygb better outcomes terms weight loss two years surgery compared lsg impact lrygb lsg tdm htn osas hypothyroidism similar however lrygb significant resolution gerd compared lsg
aim determine placebo response rate associated different types placebo interventions used psychological intervention studies irritable bowel syndrome methods randomized controlled trials comparing psychological interventions stress management relaxation therapy cognitive behavioral therapy short term psychodynamic therapy hypnotherapy treatment adult patients irritable bowel syndrome ibs diagnosed manning rome criteria adequate placebo control treatment reporting data ibs symptom severity identified searching pubmed embase cochrane library cinahl psycinfo databases full text articles written english published february peer reviewed journals selected present review placebo interventions considered adequate number sessions amount time spent therapist active treatment placebo response rate prr computed ibs symptom severity primary outcome measure well anxiety depression quality life secondary outcome measures results six studies total patients met inclusion criteria four studies used educational intervention whereas two studies used form supportive therapy placebo intervention prr ibs symptom severity ranged pooled mean relative prr secondary outcome measures ranged anxiety depression quality life prr associated pharmacological treatments treatment dietary bran complementary medicine ranged contrary expectations prr studies psychological interventions comparable studies pharmacological dietary alternative medical interventions conclusion prr probably determined larger extent patient related factors expectations desire treatment effective content placebo intervention
aim evaluate brain involvement quiescent crohn disease patients fatigue using quantitative magnetic resonance imaging mri methods multiple mri techniques used assess cerebral changes quiescent patients fatigue defined least points point numeric rating scale compared healthy age gender matched controls without fatigue furthermore mental status assessed cognitive functioning based neuropsychological inventory including different domains global cognitive functioning memory executive functioning addition mood quality life scores cognitive functioning mood status correlated mri findings study groups results reduced glutamate glutamine glx glu gln concentrations ratios total creatine found patients compared controls significant increased cerebral blood flow found patients min compared controls min patients encountered significantly depressive symptoms cognitive functioning scores related memory executive functioning lower patients scores showed correlation depression anxiety correlation found subcortical volumes patients controls weighted analysis addition correlation found mental status mri findings conclusion work shows evidence perfusion neurochemical mental differences brain patients fatigue compared healthy controls
aim investigate serum mean platelet volume mpv levels acute pancreatitis patients assess whether mpv effectively predicts disease severity methods included consecutive patients group consecutive patients colorectal polyps endoscopic treatment control group complete blood counts liver function platelet indices mpv coagulation parameters lactate dehydrogenase ldh reactive protein crp measured days admission receiver operating characteristic curves used compare sensitivity specificity mpv white blood cell wbc ldh crp predicting severity modified glasgow prognostic score mgps revised atlanta criteria used evaluate disease severity results mpv levels significantly lower group control group day day day admission addition mpv values lower day admission day day day patients based mgps patients diagnosed mild patients severe significant difference mean mpv levels patients diagnosed mild severe based mgps according revised atlanta criteria patients without persistent organ failure non severe acute pancreatitis non sap group patients persistent sap group mpv levels significantly lower sap group non sap group day admission day admission using cut value overall accuracy mpv predicting sap according revised atlanta criteria auc sensitivity specificity superior accuracy traditional markers wbc auc ldh auc conclusion mpv used additional cost useful noninvasive biomarker distinguishes persistent without persistent day hospital admission
aim investigate influence interferon free antivirus therapy lipid profiles chronic hepatitis virus genotype hcvb infection methods interferon free antiviral agents used treat patients chronic hcvb infection changes serum lipids achieved sustained virologic response svr examined treatment regimen included daclatasvir plus asunaprevir dcv asv sofosbuvir plus ledipasvir sof ldv svr achieved patients treated dcv asv patients treated sof ldv two patient groups dcv asv svr sof ldv svr serum total cholesterol low density lipoprotein cholesterol ldl high density lipoprotein cholesterol hdl triglycerides measured baseline treatment treatment longitudinal changes lipid profiles analyzed results serum levels ldl hdl significantly increased throughout observation period dcv asv svr sof ldv svr groups antivirus treatment increases ldl significantly greater sof ldvsvr group dcv asv svr group therapy serum levels ldl similar two groups significantly greater baseline approximately increase derived increased ldl multiple regression analysis difference therapy protocol dca asv sof ldv independent predictor significantly associated increase ldl therapy conclusion serum cholesterol significantly increased sof ldv treatment treatment hcv elimination associated similar increase cholesterol regardless therapy protocol
aim report accurate diagnostic possibility offered endoscopic ultrasound guided cutting holes deep biopsy eus chdb pathologic diagnosis gastric infiltrative tumors gastrointestinal submucosal tumors methods ten consecutive patients suspected gastric invasive tumors gastrointestinal submucosal tumors underwent eus chdb novel vertical diathermic loop reviewed medical data analysed effectiveness safety new method final diagnosis based surgical pathology clinical imaging follow results eus chdb performed successfully ten patients neither severe haemorrhage perforation occurred patient among ten patients three cases gastric linitis plastica one case gastric lymphoma five cases gastrointestinal stromal tumors gists one case chronic non atrophic gastritis nine cases conclusion eus chdb may technically feasible safe option patients gastric infiltrative tumors gastrointestinal submucosal tumors eus chdb may used remedial even preferred biopsy method submucosal lesions
aim study mucosal addressin cellular adhesion molecule madcam vascular endothelial growth factor vegf targeted contrast enhanced ultrasound ceus assessment murine colitis carcinogenesis methods cbl mice challenged dextran sodium sulfate dss three six nine days study development acute colitis ultrasound performed without addition unspecific contrast agents madcam targeted contrast agent used detect quantify madcam expression inflammatory driven colorectal azoxymethane aom dss induced carcinogenesis examined day using vegf targeted contrast agent highly specific tissue echogenicity quantified using specialized software sonographic findings correlated tissue staining western blot analysis immunohistochemistry quantify degree inflammation stage carcinogenesis results native ultrasound detected increased general bowel wall thickening correlated progressed severe dss colitis healthy mice six days dss nine days dss moreover sonographic findings correlated well clinical parameters weight loss histological damage acute dss induced murine colitis ceus targeted madcam detected differentiated stages mild moderate severe colitis via calculation mean pixel contrast intensity decibel employing aom dss induced carcinogenesis model tumor development monitored ceus targeted vegf detected significantly increased echogenicity tumors compared adjacent healthy mucosa healthy mucosa tissue echogenicity strongly correlated histological analysis immunohistochemistry findings vegf positive cells high power fields healthy mucosa dss start dss start conclusion molecularly targeted ceus highly specific non invasive imaging modality characterizes murine intestinal inflammation carcinogenesis vivo
aim chronic health conditions associated poor academic outcomes study examines relationship health conditions specialist health service utilisation academic performance australian children methods quasi longitudinal study school entrant health questionnaire survey tool parent report children health data children entering school matched national assessment program literacy numeracy naplan linear logistic regressions used examine associations health conditions use specialist health service reading numeracy scores results study comprised children children allergies low birth weight developmental delay diabetes spina bifida cystic fibrosis birth abnormality speech problems intellectual disability attention deficit hyperactivity disorder lower numeracy scores without conditions children higher odds national minimum standard numeracy children developmental delay epilepsy dental problems speech intellectual disabilities low birth weight lower reading scores without conditions higher odds odds ratio odds ratio national minimum standard reading children health conditions ever accessed specialist health services differ academic performance used specialist health services conclusions health conditions put children risk poorer academic performance interventions prevent appropriate support services schools considered
aim goal study investigate relationship gastrointestinal complaints dyspepsia irritable bowel syndrome hematological parameters among recurrent aphthous stomatitis ras patients material method forty four ras patients diagnosis recurrent oral ulcers oral mucosa included study answered questionnaire concerning oral aphthous properties dyspepsia problems irritable bowel syndrome routine hematological screening hemoglobin vitamin folic acid tsh analyzed retrospectively data analyses performed using spss results constipation complaints females statistically frequent males positive statistically moderate significant correlation time passed without aphtha lymphocyte level however association time passed without aphtha age aphtha recurrence frequency vitamin levels discussion determined positive correlation aphtha size lymphocyte level studies designed light association ras gastrointestinal system disease
aim internet things iot playing vital role fields world especially smart home automation system iot smart home system runs conventional network bluetooth internet implemented based embedded microcontroller sensor environment days major crisis residential premises leakage liquefied petroleum gas due hindrance gas sensor deployed smart home environment detection gas leakage sms short message service sent authorized user gsm electric power supply turned help fire sensor relay control detection gas leakage smart home window opened means window sensor concentration gas gets reduced slowly hence survey done gas leakage detection controlling system overcome trouble conclusion hence occurrence accidents due lpg gas leakage controlled using proposed technique listed possible solution section
aim objective present meta analysis investigate whether cytotoxic lymphocyte associated antigen ctla polymorphisms associated ankylosing spondylitis susceptibility methods systematic search conducted pubmed enbase springer link database april odds ratios ors confidence intervals cis used assess strength association ctla risk subgroup analysis based geographic region sensitivity analysis also conducted results five studies eligible meta analysis including cases controls results showed significant association found ctla additive model dominant model dominant model recessive model respectively although subgroup analysis demonstrated association ctla polymorphisms susceptibility europe taiwan association found iran dominant dominant models exclusion individual study alter significance final outcome excepting result omitting study huang etal conclusions present results suggest ctla may major susceptibility locus humans relationship may affected different geographic populations
aim study assessed mrna expression podocyte associated molecules urinary sediments patients type diabetes mellitus relation urinary podocytes biomarkers podocyte injury proximal tubule dysfunction methods total patients type healthy subjects enrolled cross sectional study assessed concerning urinary podocytes urinary mrna podocyte associated genes urinary biomarkers podocyte damage dysfunction results found significant differences urinary mrna podocyte associated molecules relation albuminuria stage multivariable regression analysis urinary mrna nephrin podocin alpha actinin associated protein glomerular epithelial protein glepp adam kappa correlated directly urinary podocytes albuminuria urinary alpha microglobulin urinary kidney injury molecule nephrinuria urinary vascular endothelial growth factor urinary advanced glycation end products age indirectly egfr conclusions patients type association urinary mrna podocyte associated molecules biomarkers podocyte damage dysfunction glepp adam kappa may considered additional candidate molecules indicative early diabetic nephropathy age could involved association
aim lack research adolescents undergo double blind placebo controlled food challenges aim study investigate food allergic adolescents experiences consequences double blind placebo controlled food challenges methods qualitative descriptive interview study included adolescents aged years total elimination cows milk hens eggs cod due food allergies participants initially identified large population based cohort study interviewed months completing challenges results double blind placebo controlled food challenge proved complex experience adolescents involving fear potential reactions hope food could reintroduced experiences challenge described three themes facing fears secure environment hesitant curious unknown tastes waiting unknown food reactions experiences challenge described two themes gaining control freedom continuing old habits negative challenge consistently associated reintroduction challenged food conclusion study highlighted importance considering adolescents expectations experiences challenge reintroduction process ensure desirable changes dietary habits follow ups performed regardless outcome challenges
aim study examined change months participants frequent episodic migraine adequate treatment usual completed online behavioural training obt migraine self management either directly group months watchful waiting group methods participants completed questionnaires online headache diary migraine monitor following international classification headache disorders baseline post training month follow extended baseline group post training group group month follow group month follow statistical analyses conducted observed data without imputation missing observations results groups highly comparable data time revealed benefits response obt significant group differences change achieved training episodes group group improved attack frequency higher participants attacks per month baseline effects obt durable months follow conclusions obt beneficial frequent episodic migraine deserves special efforts care self management variants obt reach patients easily supplement efforts durable results
aim study investigated whether allergies among schoolchildren increased sweden whether geographical differences observed previous studies remained methods collected questionnaire data asthma allergic rhinoconjunctivitis arc eczema children aged seven eight years molndal gothenburg south western sweden kiruna northern sweden regions questions used three studies extra questions food allergy intolerance added results total prevalence asthma arc eczema respectively asthma prevalence remained higher kiruna significant regional differences seen arc eczema almost reported history food allergy intolerance higher prevalence kiruna allergy risk reduced parents born outside sweden conclusion prevalence arc continued increase increases asthma eczema started level geographical differences remained total allergy rates similar kiruna molndal
aim study done investigate experiences family caregivers people multiple sclerosis stigmatization iranian health care context background stigmatization observed obviously among patients studies conducted stigma among family caregivers patients methods qualitative study thematic analysis done explore issue fourteen family caregivers patients selected purposive sampling data collected depth unstructured interviews results four main subthemes emerged analysis transcripts feeling shame fear ridiculed others ignored family concealing disease secure perceptions disease conclusions healthcare professionals encouraged inform caregivers social engagement strategies train management stigma important factor reduction social problems elsevier inc rights reserved
aim assess variability symptom presentation explanatory models psychosis people different ethnic groups methods clients first episode psychosis identified black african black caribbean white european recruited early intervention programmes toronto hamilton compared results ethnic group symptom profiles explanatory models illness results clients black caribbean origin lower odds reporting speaking incomprehensibly black african clients greater odds reporting persistent aches pains black african clients lower odds attributing cause psychosis hereditary factors substance abuse lower odds assigning responsibility illness conclusions understanding differences illness models ethnic minority groups may help improve cultural competence mental health services
aim determine whether gypenosides protective effects experimental autoimmune optic neuritis eaon methods mice randomly divided seven groups control group model group three different density gypenosides monotherapy methylprednisolone monotherapy combination gypenosides methylprednisolone group control group subcutaneously injected oil emulsion adjuvant groups subcutaneously immunized emulsified mixture myelin oligodendrocyte glycoprotein mog peptide induce eaon mice gypenosides groups administered injections daily three concentrations gypenosides respectively mice methylprednisolone group combination treatment group injected daily methylprednisolone methylprednisolone gypenosides respectively mog immunization visual evoked potential vep optical coherence tomography oct histopathologic examination performed post inoculation results expressed mean sem data evaluated oneway anova followed tukey games howell test results compared control group latency prolonged model group combination treatment alleviated change vep average peripapillary retinal nerve fiber layer rnfl thickness reduced model group gypenosides treatment remarkably diminished degree rnfl degeneration pathomorphological results showed decrease demyelination inflammatory reactions combination group compared model group gypenosides treatment also alleviated degree axonal loss conclusion treatment gypenosides exerts protective effects retinal nerve fibers axons eaon combined gypenosides methylprednisolone reduces demyelination acute stage eaon
aim map health related quality life qol clinical parameters basfi asdas crp measure covariates methods prospective multicenter non interventional observation study ankylosing spondylitis collected data qol clinical outcomes initial four subsequent visits employed simple linear regression analysis cross sectional dataset fixed effect random effect pooled linear regression longitudinal dataset results showed basfi asdas crp strong robust predictors utilities regression specifications together sex female invalidity activity impairment additionally longitudinal regression analysis showed fixed effect model may viable alternative commonly used random effect model pooled linear regression due nature dataset conclusion one first studies using fixed effect model longitudinal patient level data although method widely used economics
aiming designing biogas electricity advanced systems solid oxide fuel cells promising candidates benefit scalability plant sizes suit anaerobic digesters potentialities biogas solid oxide fuel cells applications implementation external pre reformer usually considered however possibility perform direct fuel feeding solid oxide fuel cell offers new opportunities towards realization lean systems competitive especially small scale installations farm biogas electricity conversion frame scientific literature rather poor cover gap system simulations called two reasons first demonstrate potential efficiency gain new concepts second provide meaningful support long term experimental investigation solid oxide fuel cells operated upon direct feeding unreformed biogas current study compares two system designs biogas utilization solid oxide fuel cells conventional one realizes biogas steam reforming prior fuel cell novel concept based direct feeding partially upgraded biogas means carbon dioxide separation membranes main outcome study system equipped carbon dioxide separation membranes achieves better perforinances conventional competitor scoring energy efficiency exergy efficiency compared respectively exhibited reformer based system lack high endothermic process steps membrane based system also convenient whether heat recovery required producing combined heat power efficiency versus obtained system moreover results sensitivity analysis impact membrane reforming operating parameters overall system performances justify convenience adopting solution biogas direct feeding even hypothesis poorly performing membrane optimized reformer membrane based system exhibits gain system energy combined heat power efficiency respectively regard reforming based concept forcefulness result reinforced preliminary evaluation capital expenditures represents economic advantage beside economic revenue coming higher energy conversion efficiency elsevier ltd rights reserved
aiming problem parking information release large flow release information timely accurately internet vehicle iov urban traffic parking system proposed based parking lot sensor network sensor combination electrical control circuits system use core technology internet things iot combinate timer elastic pressure switch pressure sensor electrical circuits realize parking information acquisition release query reservation parking navigation reliable accurately experimental results shows electrical control circuits better management parking information accurately car user uses vehicle terminal search target parking lot receive parking information system alleviate urban traffic improve utilization efficiency urban parking lot future city social development provide better technical support basis
aims previous study reported significant month birth effect mood seasonality northern hemisphere higher mood seasonality observed university students born spring summer months long photoperiod compared born autumn winter months short photoperiod aim study test hypothesized photoperiod effect comparing correlation month birth mood seasonality two countries located opposite poles terrestrial globe italy northern hemisphere new zealand southern hemisphere basis photoperiod birth hypothesis expected find higher mood seasonality among individuals born months longer photoperiods countries methods seasonal pattern assessment questionnaire administered young adults women men italians new zealanders ages ranging years global seasonality score measure mood seasonality calculated seasonal pattern assessment questionnaire results significant overall month birth effect observed global seasonality score men men born april august corresponding italy long photoperiod new zealand short photoperiod higher mood seasonality born february regardless country conclusions significant month birth effect found mood seasonality results support hypothesis based photoperiod effect
aims objectives discrimination health care workers including dentists human immunodeficiency virus hiv infected persons noted main aim present study assess knowledge attitude practice towards hiv patients among dentists trichur district kerala materials methods cross sectional survey conducted among dentists practicing trichur district kerala data collected using pretested self administered item questionnaire statistically analyzed using spss software version results participants unwilling treat hiv patients statistical significance found willingness treat hiv infected patients age groups well willingness treat hiv infected patients ethical responsibility conclusion staff fears increased personal risk found frequently reported concerns treating hiv patients among dentists trichur district kerala senior dentists showed reluctance treat hiv positive individuals
aims analyse outcomes supraventricular tachycardia svt ablations performed within prospective german ablation quality registry methods results data patients underwent catheter ablation svt january january treat atrial fibrillation afib procedures atrial flutter afl atrioventricular nodal entrant tachycardia avnrt atrioventricular entrant tachycardia focal atrial tachycardia prospectively collected patients followed least year periprocedural success rate ranging focal avnrt kaplan meier mortality estimate year overall high afl group focal group recurrence ablated another symptomatic svt observed patients ranging avnrt afib repeat ablation performed patients year survivors perceived ablation therapy successful partly successful unsuccessful even patients arrhythmia recurrence perceived ablation successful partly successful would still undergo repeat ablation institution conclusion ablation therapy svt safe procedure bringing symptomatic improvement satisfaction three quarters patients year even patients arrhythmia recurrence high satisfaction level adherence ablating institution could documented strikingly high mortality stroke rates follow observed afl patients apparently need consistent long term anticoagulation medical attention
aims assess knowledge attitudes experience group malaysian dental health care providers regarding child physical abuse cpa cases terms frequency occurrence diagnosis risk factors reporting methods questionnaire distributed dental health care providers attending national paediatric dentistry conference kuantan malaysia demographical variables knowledge attitudes experience cpa risk factors reasons reporting abuse cases collected descriptive statistics bivariance analysis performed level statistical significance applied analyses results response rate half respondents stated frequency occurrence cpa common malaysia full agreement dental health care providers determined concerning identification signs cpa risk factors although aware reporting cpa legal requirement malaysia reported cases lack adequate history main reason reporting virtually two thirds respondents indicated received sufficient information cpa willing educated diagnose report child abuse cases respectively conclusions considerable disparities respondents knowledge attitudes regarding occurrence signs suspected cases risk factors reporting cpa despite aware cases handful reported enhancement education malaysian dental health care providers recognising reporting cpa recommended
aims investigate whether serum uric acid predicts adverse outcomes persons indices diastolic dysfunction general population methods results performed prospective cohort study among women men endpoints cause mortality incident myocardial infarction incident ischaemic stroke stratified analyses echocardiographic markers diastolic dysfunction uric acid independent variable interest hazard ratios estimated per mol increase baseline uric acid multivariable adjusted cox proportional hazards models showed uric acid predicted cause mortality subjects ratio interaction ratio category uric acid elevated uric acid increased mortality risk persons wave deceleration timems respectively interaction furthermore participants isovolumetric relaxation time mortality risk higher increasing uric acid interaction finally elevated uric acid predicted ischaemic stroke subjects severely enlarged left atria interaction conclusions increased uric acid associated higher cause mortality risk subjects echocardiographic indices diastolic dysfunction higher ischaemic stroke risk persons severely enlarged left atria
aims adults experienced armed conflicts republic georgia exposed multiple traumatic events stressors many years aim investigate coping strategies used conflict affected persons georgia association mental disorders method cross sectional survey conducted adults representing internally displaced persons idps conflicts former idps returned homes conflict post traumatic stress disorder depression anxiety coping strategies measured using trauma screening questionnaire patient health questionnaire generalised anxiety adapted version brief coping inventory respectively descriptive multivariate regression analyses used results coping strategies use humour emotional support active coping acceptance religion significantly associated better mental health outcomes coping strategies behavioural mental disengagement denial venting emotions substance abuse gambling significantly associated poorer mental health outcomes reported use coping strategies varied significantly men women strategies addressed conclusions many conflict affected persons georgia still suffering mental health problems years conflicts number specific coping strategies appear associated better mental health encouraged supported possible
aims aim study estimate frequencies patterns skin care applied skin care products home care nursing setting germany background skin care belongs core activities nursing practice especially aged long term care settings clients vulnerable various skin conditions dry skin one prevalent problems using mild skin cleansers regular application moisturizing leave products recommended today quantitative empirical data nursing skin care practice home community design multicentre cross sectional study conducted july methods home care clients german home care nursing setting randomly selected instructed nurse raters performed data collection using standardized forms variables included demographics skin care needs skin caring activities results approximately home care clients received skin care interventions majority washed two thirds received leave product daily large heterogeneity cleansing skin care product use often product labels unknown product types selected haphazardly conclusion skin care interventions play significant role home care nurses considerable responsibility skin health skin care provided meet recent recommendations importance targeted skin cleansing care might underestimated confusing variety skin care products available often labels provide little information regarding ingredients guidance affect skin health
aims hypothesis hypothesised type diabetic patients established diabetic sensorimotor polyneuropathy dspn would segmental pan enteric dysmotility comparison healthy age matched controls aimed investigate relationships gastrointestinal function degree dspn clinical symptoms methods observational comparison made patients dspn men mean age years range years representing baseline data ongoing clinical trial representing secondary analysis baseline data collected ongoing double blind randomised controlled trial investigating neuroprotective effects liraglutide healthy participants men mean age years range underwent standardised wireless motility capsule test assess gastrointestinal transit patients vibration thresholds michigan neuropathy screening instrument patient assessment upper gastrointestinal symptom questionnaires recorded results compared healthy controls patients showed prolonged gastric emptying min small bowel transit min colonic transit interquartile range iqr min iqr min whole gut transit time iqr min iqr min patients also showed increased fall across ileocaecal junction associated prolonged colonic transit multivariable regression controlling sex disease duration glycaemic control demonstrated association whole gut transit time total gcsi conclusions interpretation pan enteric prolongation gastrointestinal transit times acidic caecal may represent heightened caecal fermentation present patients type diabetes potential implication delayed gastrointestinal transit bioavailability nutrition pharmacotherapeutic glycaemic control warrants investigation
aims introduction stopping smoking deserves high priority preventing complications diabetes however sparse data available regarding efficacy pharmacotherapy smokers diabetes assessed efficacy safety varenicline smokers diabetes participated double blind randomized placebo controlled studies materials methods retrospective pooled analysis included data smokers cigarettes per day diabetes participants received varenicline placebo weeks examined carbon monoxide confirmed continuous abstinence rates cars weeks compared safety participants without diabetes results participants diabetes varenicline placebo week car higher varenicline placebo odds ratio week car odds ratio week car varenicline placebo odds ratio commonly reported adverse events participants diabetes varenicline placebo nausea headache insomnia incidences similar participants without diabetes respectively weight gain quitters diabetes similar without diabetes conclusions varenicline effective well tolerated aid smoking cessation individuals diabetes safety comparable participants without diabetes
aims correct sizing left atrial appendage laa closure system important avoid redeployment device peri device leaks aims study assess significance two dimensional transoesophageal echocardiography tee real time transoesophageal echocardiography tee angiography measuring size laa landing zone determine impact sizing laa closure device furthermore investigated relevance volume loading laa size methods results prospective study patients underwent tee tee hours prior laa closure beginning procedure procedure volume loading average angiography performed immediately implantation maximal diameter versus perimeter versus area versus laa increased significantly volume loading highest correlation measurements laa device size found tee derived perimeter area whereas maximal diameter measured tee angiography correlated less closely sizing based tee measured perimeter resulted undersizing implanted device peri device leaks occurred seven cases associated lower compression laa devices versus patients without leaks conclusions volume loading laa closure increases laa dimensions significantly tee measurements show closer correlation laa closure device size tee angiographic measurements
aims despite efficacy intravesical onabotulinumtoxina botox therapy urgency urgency incontinence daytime frequency value treatment nocturia remains unclear aim prospective observational study assess effect onabotulinumtoxina night time symptoms women overactive bladder oab including nocturia night time urgency incontinence nocturnal voided volume end points methods women idiopathic oab least one episode urgency urinary incontinence uui per day micturitions per nocturia episodes per night enrolled patients nocturnal polyuria excluded botox administered intra detrusor injections post void residual volumes pvr checked weeks participants completed day bladder diary king health questionnaire khq weeks treatment reported efficacy treatment visual analog scale vas final follow visit results seventy six women completed study botox injections effective reduction nocturia episodes mean night time uui episodes compared baseline increase mean voided volume night time micturitions patients reported mean points improvement vas urinary retention required self catheterization observed three patients conclusions intravesical botox injection provides significant benefit night time symptoms oab patients results applicable women without nocturnal polyuria prove useful counseling patients risks benefits botox neurourol urodynam wiley periodicals inc
aims survey aimed identifying society attitude towards people mental illness slovakia method selected group comprised adult respondents years age bottom limit applied reduced item community attitudes toward mentally ill scale cami survey society attitude towards people mental illness results average score reached respondents reached points indicating lower stigmatization rate presumed investigation revealed prejudice stigmatizing attitudes significant part population survey confirmed statistically significant differences attitudes terms gender age within categories education socio economic status occupation also confirmed statistically significant relation attitude age conclusion survey confirmed rather neutral slightly positive attitude slovak population towards people mental illness existence attitudes burdened fear revealed cases indicating need continuous education society subject matter
aims paediatric patients mitral valve disease limited options prosthetic replacement based long experience stented bovine jugular vein graft melody valve right ventricular outflow tract aimed test use melody valve surgical implant mitral position small group infants congenital mitral disease methods results eight patients aged months years congenital dysplasia underwent melody valve implantation mitral position march october sutured annulus melody valve expanded balloon catheter achieve best diameter two patients needed ecmo assistance traditional repair melody valve successfully implanted possible bail however neither recovered multi organ failure died spite well functioning melody prosthesis follow one patient underwent catheter based balloon expansion valve conclusions medium term results procedure encouraging melody valve opens opportunity carry replacement children earlier time point potential revolutionise treatment disease
aims patients treated anticoagulants may experience serious bleeding require urgent surgery intervention may benefit rapid anticoagulant reversal exploratory analysis assessed healthcare resource utilization hcru patients treated idarucizumab specific reversal agent dabigatran etexilate materials methods verse nct prospective multi center open label study evaluating idarucizumab dabigatran reversal patients serious bleeding group undergoing emergency surgery procedures group hcru outcome measures evaluated first patients enrolled use blood products pro hemostatic agents length stay los hospital los intensive care unit icu results blood products pro hemostatic agents given patients group patients group day day surgery overnight hospital stay reported patients group median los range bed days group overnight hospital stay median los range bed days group patients admitted icu least day median los range days group number median los range days limitations lack control group small patient numbers limit strength conclusions conclusions use idarucizumab may simplify emergency management dabigatran treated patients life threatening bleeds reduce perioperative complications patients undergoing emergency surgery
aims protocol security important concern network security ensures security integrity data transmission internet secure network data illegimate attempt extract content data cloud computing advance computing technology internet users materials methods enhance system without modify changing resources internet cloud technology resources get cloud system data transmit secure channel results paper focus protocol security private cloud system deployment security poodle discovered google team oct
aims study vivo regulatory role glutamate osteoblast osteoclast differentiation less advanced present study investigated effect dextromethorphan dxm methyl aspartate receptors nmdars antagonist osteoporosis development main methods order examine role glutamate bone metabolism ovariectomized ovx female wistar rats injected three times per week weeks either saline beta estrodiol dxm intraperitoneally serum samples collected every two weeks measuring osteocalcin terminal telopeptide type collagen cfx level rats sacrificed week femurs harvested micro scanning mechanical strength key findings saline treated group osteocalcin level significantly lower sham operated rats weeks operation ctx levels affected estrogen treatment positive control partially inhibited ovx induced reduction osteocalcin serum level dxm injection prevented ovx induced reduction osteocalcin expression significantly upregulated ctx expression micro scan showed bone volume density decreased significantly dxm treated rats compared sham operated rats mechanical strength assay maximum failure load dxm treatment significantly lower groups significance treatment dxm upregulated markers ovx rats however greater effect marker significant benefit bone volume density bone strength elsevier inc rights reserved
aims aim study analyze whether uroflowmetry parameters helpful diagnosing overactive bladder oab working hypothesis flow curves patients oab symptoms would appear sharp peak flow rate short duration high amplitude lasting short period urgency sensation followed reduced urine flow introduced new parameter called flow index defined average divided maximal urine flow rates potential marker diagnosing oab methods conducted retrospective study analyzing urodynamic studies performed women lower urinary tract symptoms based subjective clinical symptoms patients divided four groups pure oab mixed urinary incontinence predominant oab mui oab mixed urinary incontinence predominant sui mui sui pure sui patients results comparing pure oab pure sui patients strong statistically significant difference found mean respectively similar results found comparing patients pure oab mui oab versus patients pure sui mui sui mean respectively conclusions may used additional marker oab diagnosis wiley periodicals inc
aims main goal study determine characteristics parents sought help two prevention programmes due adolescent child presents high risk behaviours methods sample composed parents fathers mothers information socio demographic characteristics psychopathological symptoms emotional states educational styles maladjustment everyday life collected findings results show statistically differences gender mothers obtained higher degree psychopathology symptoms maladjustment parental stress relative fathers mothers also used frequently authoritative permissive parenting styles general authoritarian permissive parenting styles stressful perceptions parental role associated psychopathological symptoms maladjustment finally following variables predicted severity psychopathological symptoms secondary education maladjustment stressful perceptions parental role authoritarian permissive parenting styles conclusions study highlights need assess psychological problems parents adolescents high risk behaviours develop specific intervention programmes
aims assess healthcare resource use costs among irritable bowel syndrome ibs diarrhea ibs patients without evidence inadequate symptom control current prescription therapies estimate incremental cause costs associated inadequate symptom control methods ibs patients aged years medical claim ibs icd either claims diarrhea icd claim diarrhea plus claim abdominal pain icd claim diarrhea plus pharmacy claim symptom related prescription within year ibs diagnosis identified truven health marketscan database inadequate symptom control resource use costs assessed year following index date inadequate symptom control included following switch addition new symptom related therapy ibs related inpatient emergency room admission ibs drelated medical procedure diagnosis condition indicating treatment failure use aggressive prescription generalized linear models assessed incremental costs inadequate symptom control results ibs patients mean age years female evidence inadequate symptom control compared without inadequate symptom control patients evidence inadequate symptom control significantly hospitalizations visits use outpatient services physician office visits mean prescription fills mean annually incremental costs associated inadequate symptom control dollars driven medical service costs limitations study included commercially insured patients inferred ibs status inadequate symptom control claims conclusions inadequate symptom control associated available ibs therapies represents significant economic burden payers ibs patients
aims evaluate sampling adequacy diagnostic accuracy endometrial sap sampling device detecting endometrial lesions based histopathological examination materials methods total patients required endometrial biopsy enrolled study patients underwent endometrial biopsies sap sampler prior hysteroscopy dilatation curettage endometrial tissues obtained biopsy histopathological examination results adequate endometrial specimens obtained patients menopause endometrial thickness types endometrial diseases differed significantly two groups among patients underwent hysteroscopy sampling scratches observed uterine cavity cases compared traditional methods hysteroscopy sampling diagnostic sensitivity specificity positive negative predictive values endometrial carcinoma endometrial atypical hyperplasia respectively misdiagnosed occurred lesions focal localized small part uterine cavity sampling diagnostic sensitivity polyps two patients submucosal leiomyoma went undiagnosed based sample specimens conclusion endometrial sampling using sap sampler minimally invasive alternative technique obtaining adequate endometrial specimens histopathological examination sap sampler useful detecting endometrial carcinoma atypical hyperplasia cases highly suspected localized however method useful detecting endometrial polyps submucosal leiomyomas
aims seek feedback clinical oncologists experiences specialty training applicable transition working consultant national health service materials methods clinical oncologists gaining certificate completion training july june identified records held royal college radiologists approached may take part online survey results survey completed clinical oncologists invited take part response rate respondents agreed specialty training equipped well clinical skills radiotherapy planning systemic therapy tumour site diagnosis treatment fell advanced radiotherapy techniques non clinical skills respondents felt training equipped less deal leadership management research clinical governance despite wanting respondents undertake programme oop activity gain new skills respondents undertake oop activity agreed helped prepare first consultant post broad support frcr examination first frcr examination modules physics pharmacology tumour biology radiobiology seen relevant clinical practice respondents final frcr examination seen essential technical specialty like clinical oncology respondents working new consultant survey revealed heavy workload respondents always almost always working beyond contracted hours issues concern identified discrepancies advertised consultant job plans ineffectiveness job plan review process traine econsultant transition often difficult time yet respondents allocated formal mentor respondents rely informal arrangements seeking support advice medical colleagues conclusions general respondents satisfied specialty training transition training working new consultant areas possible improvement identified employers well involved organising specialty training royal college radiologists published elsevier ltd rights reserved
aims test efficacy community health worker chw delivered stress management intervention psychosocial glycemic cortisol outcomes among latinos type diabetes methods randomized controlled trial compared chw delivered diabetes education one group session plus chw delivered group sessions psychosocial variables urinary cortisol measured baseline posttreatment hbac measured baseline posttreatment month follow results intent treat analysis compared showed significantly improved symptoms depression anxiety self reported health status significant group effects hbac diabetes distress urinary cortisol however dose response effect hbac diabetes distress increasing attendance sessions associated greater improvements hbac diabetes distress conclusions first randomized controlled trial demonstrating chws improve psychological symptoms self reported health among latinos type diabetes efforts increase intervention attendance may improve hbac diabetes distress elsevier ireland ltd rights reserved
aims examined interaction sex steroid hormones obesity regard insulin resistance type diabetes using nationally representative data methods data men aged years participated third national health nutrition examination survey analyzed multiplicative interaction calculated cross product interaction terms multivariable logistic regression models additive interaction assessed relative excess risk due interaction reri results adjusting demographic lifestyle covariates odds greatest among obese men low free testosterone high androstanediol glucuronide multiplicative interactions total testosterone free testosterone free estradiol index fei statistically significant central obesity overweight obesity regarding significant additive interactions obesity central obesity detected total testosterone reri shbg reri fei reri regard beta cell dysfunction conclusions findings add evidence suggesting low testosterone high estradiol may associated greater risks interacting overall central obesity adult men published elsevier inc
aims relationship bladder pain urinary urgency sensations poorly understood analyzed relationship locations intensities urgency pain sensations felt filling cystometry methods participants completed king health questionnaire khq indicate presence bladder pain urgency cystometry participants scored intensity urgency pain suprapubic urethral region vas scale baseline first desire normal desire strong desire void maximum cystometric capacity filling allocated participants six groups reporting urgency pain symptoms neither friedman test used ascertain scores increased significantly wilcoxon signed rank test used demonstrate difference scores agreement findings cystometry tested mann whitney results total women participated participants reported pain reported urgency reported symptoms pain urgency scores significantly increased cystometry participants reporting pain suprapubic pain rated significantly higher urethral pain participants reporting symptoms felt urgency pain pain suprapubically urethrally participants reporting urgency scored suprapubic urethral urgency similarly desires conclusions pain urgency well differentiated sensations felt different locations although pain seemingly easier localized neurourol urodynam wiley periodicals inc
aimsbladder dysfunction frequent course multiple sclerosis observed patients urinary symptomatology feature first episode minority cases often shows characteristics overactive bladder oab voiding symptoms seen less frequently often combination oab neural control micturition complex involving systems located brain spinal cord periphery implicating central noradrenergic serotonergic dopaminergic activities urinary disorders also linked anxiety depression conditions connected hypothalamus pituitary adrenal axis activity study aimed investigate neurochemical neuroendocrine correlates bladder dysfunction early methodswe included patients first demyelinating episode suggestive drug free assessment evaluated presence urinary symptomatology estimated csf levels main metabolites noradrenaline serotonin dopamine well csf acth serum cortisol resultsin total patients reported urinary dysfunction suggestive oab four coexistent voiding symptomatology serotonin metabolite hiaa significantly reduced patients oab syndrome differences metabolites noradrenaline mhpg dopamine hva additionally significantly lower serum cortisol borderline lower csf acth found patients oab conclusionsms patients oab syndrome first demyelinating episode show reductions central serotonergic activity stress hormones whether changes persist later disease stages remains investigated neurourol urodynam wiley periodicals inc
aimsthe microbiome term used symbiotic microbial colonisation healthy organs studies found bacterial identifiers within voided urine apparently sterile conventional laboratory culture accordingly may health disease implications methodsthe international consultation incontinence research society ici established literature review expert consensus discussion focussed increasing awareness urinary microbiome potential research priorities resultsthe consensus considered discrepancy findings conventional clinical microbiology methods generally rely culture parameters predisposed towards certain expected organisms discrepancy selective culture rna sequencing study species specific ribosomal rna increasingly clear highlights possibility protective harmful bacteria may overlooked microbiological methods selective strong signals existence core urinary microbiome human urinary tract particularly emerging ageing consensus reviewed potential relationship patient microbiome lower urinary tract dysfunction whether low count bacteriuria may clinically significant mechanisms could associate micro organisms lower urinary tract symptoms conclusionskey research priorities identified include need establish scope microbiome across range normality clinical presentations gain consensus testing protocols proteomics study enzymatic functions may necessary since different bacteria may overlapping phenotype longitudinal studies risk factors exposure cumulative risk emergence disease need undertaken neurourol urodynam wiley periodicals inc
aimsto assess effects repeat treatment onabotulinumtoxin onabont women refractory idiopathic detrusor overactivity methodsanalysis open label extension study large randomized placebo controlled trial onabont participants randomized receive onabonta placebo offered two onabonta injections year period analysis primary outcome duration treatment effect patient reported symptom return weibull proportional hazards regression models fitted bayesian framework estimate missing times multivariable hazard regression analysis hazard ratio credible intervals cri compared repeated injections adjusting differences baseline symptom severity secondary outcomes included inter injection interval incontinence urgency voiding episodes weeks injection resultsfour hundred forty two active injections administered patients one two three injections time symptom return injection number days respectively median inter injection intervals receiving second third injection days range days range statistically significant differences symptom outcomes time symptom return cri injection cri injection observed conclusionsrepeated onabont injections consistent efficacy duration action appears long term placebo effects groups randomized patients implications open label extension studies
aimsto assess patient reported outcomes pros patients overactive bladder oab receiving novel adrenoceptor agonist mirabegron methodsdata randomised double blind controlled phase iii trial patients aged years oab symptoms months analysed patients received placebo mirabegron day tolterodine extended release orally daily weeks week placebo run prespecified analysis pros changes oab questionnaire oab patient perception bladder condition ppbc work productivity activity impairment specific health problem wpai shp instrument patients treated mirabegron day tolterodine day placebo reported post hoc analyses oab ppbc treatment satisfaction visual analogue scale vas patients incontinent baseline also reported resultssignificant improvements placebo oab coping concern baseline final visit observed mirabegron day significant improvements parameters observed tolterodine day mirabegron day significantly increased proportion patients showing ppbc improvement placebo mirabegron day also produced greater improvements wpai shp presenteeism greater reductions absenteeism overall work impairment placebo tolterodine day impact mirabegron day treatment pros incontinent population appears greater overall oab population conclusionsat approved dose day mirabegron significantly improves oab patients perception disease quality life independent whether incontinent baseline neurourol urodynam authors neurourology urodynamics published wiley periodicals inc
aimsto assess long term patient reported outcomes following transobturator tension free vaginal tapes tvt women urodynamic mixed urinary incontinence mui methodsa secondary analysis year follow tot study women predominant stress urinary incontinence symptoms randomized undergo either inside outside tvt april april forty eight women preoperative urodynamic mui available year follow primary outcome patient reported success rate defined much improved patient global impression improvement pgi secondary outcomes included impact women quality life sexual function overactive bladder symptoms late adverse events statistical analysis performed using spss resultsforty eight women completed year follow adjusted response rate success based pgi reported improved significant difference groups clinically significant improvement quality life found cure urgency uui reported whereas worsening reported respectively one patient reported chronic groin leg pain small sample size sizeable loss follow limitations study conclusionsthis first study report long term outcomes tvt women urodynamic mui tvt associated good sustained patient reported success rate women mui years follow
aimthe aim study clarify geographical movement patients treated psychiatric facilities provide important information resources health care system psychiatric services methodswe conducted analysis nationwide data psychiatric patients collected additional survey conventional survey initially admitted inpatients months outpatients specific day identified whether patient admitted psychiatric facility located medical area residence estimated percentages within medical area within prefecture iii outside prefecture using bayesian statistical approach secondary medical area resultsthe inpatients moved across wider areas outpatients almost inpatients outpatients received medical treatment hospitals clinics within prefecture residence conclusionthe current mental health medical system japan operating according prefecture unit thus may appropriate plan medical system prefectural level
aimthe main aim study examine aetiology yield brain imaging children site locked headaches slh methodsthis study carried queen university hospital essex august august focused patients least five years age experienced least five slh attacks normal neurological examination bilateral alternating unilateral headaches excluded data collected prospectively headache diagnosis based international classification headache disorders resultswe identified eligible patients female aged years unilateral slh occipital slh vertex slh anterior headaches frequent diagnoses included migraine tension type headaches medication overuse headaches headache unspecified cases magnetic resonance imaging normal scanned showed nonspecific nonsignificant abnormality conclusionsite locked headaches likely caused primary headaches particularly migraine slh without abnormal neurological findings unlikely underlying sinister aetiology routine brain imaging required cases
aimthis study aimed identify consumer perspectives topics outcomes integrate kidney health australia caring australasians renal impairment kha cari clinical practice guidelines autosomal dominant polycystic kidney disease adpkd methodsa workshop involving three concurrent focus groups consumers patients adpkd caregivers convened guideline topics interventions outcomes identified integrated guideline development thematic analysis used analyse reasons choices resultstwenty two priority topics identified focussed non pharmacological management diet fluid intake physical activity complementary medicine pain management psychosocial care mental health counselling cognitive behavioural training education support groups also identified outcomes including quality life qol progression kidney disease kidney function cyst growth nephrotoxity almost topics outcomes suggested identified health professionals exception five topics outcomes six themes reflected reasons choices clarifying ambiguities resolving debilitating pain concern family preparedness future taking control significance impact conclusionalthough considerable concordance priority topics outcomes health professionals consumers guidelines adpkd also important discordance consumers focused fewer issues particularly lifestyle psychosocial support pain qol renal outcomes active consumer engagement guidelines development help ensure inclusion patient centred recommendations may lead better management disease progression symptoms complications psychosocial impact
aimthis study investigated researched area annual influenza vaccination rates children chronic kidney disease identified reasons nonimmunisation methodsa prospective cross sectional study conducted nephrology clinic dialysis unit tertiary paediatric medical centre august october september october parents asked complete questionnaire child immunisation influenza resultsof children studied vaccinated influenza major reason nonimmunisation parents received necessary information primary physician treating nephrologist nonvaccinated children significantly likely less two years old female parents believe benefits vaccination parents vaccinate child claimed would done vaccine offered nephrology clinic conclusionchildren kidney disease higher annual influenza vaccination rate general population still suboptimal nephrologists alerted need provide parents information influenza vaccinations available nephrology clinics
aimto compare dietary intakes young children australian guide healthy eating aghe nutrient reference values nrvs methodsdietary intakes children girls aged two three years mean years women children health watch study reported mothers using validated item food frequency questionnaire daily consumption aghe food group servings macronutrients micronutrients compared aghe nrvs using test significance set resultsno child achieved aghe targets majority consuming less breads cereals servings day vegetables meat alternatives adequate servings observed dairy fruit macronutrients within recommended ranges although exceeded saturated fatty acid recommendations children met selected nrvs consumed fruit dairy discretionary foods less breads cereals vegetables servings compared aghe recommended servings conclusionschild dietary intakes align aghe adequate nutrient profiles achieved various dietary patterns future studies involving data larger representative samples children warranted
aimto evaluate parents feedback regarding experience registering accessing funding national disability insurance scheme ndis communicating national disability insurance agency ndia methodsparents children less years age assessed child development unit cdu women children health network july june referred ndis invited complete study questionnaire regarding experience ndis questionnaire initially mailed parents response returned families telephoned complete questionnaire phone sent another copy questionnaire complete resultsof children eligible study parents completed questionnaire thirty six parents reported difficulty ndis registration process six parents difficulty regards accessing funding reported difficulty stated difficult parents comment twenty six parents reported easy communicate ndia found difficult overall parents satisfied ndis ndia unsatisfied neutral conclusionthe majority parents satisfied processes required register access funding ndis early intervention services children developmental disabilities ability communicate ndia
aimto investigate effects repeated mifepristone levonorgestrel use estrous cycle expression ovarian follicle stimulating hormone receptor fshr luteinizing hormone receptor lhr mice methodsovarian fshr lhr mrna expression measured using real time quantitative reverse transcription polymerase chain reaction protein levels measured using immunohistochemistry resultsrepeated use mifepristone levonorgestrel significantly lengthened estrous cycle decreased fshr lhr mrna protein expression ovaries mice days discontinuing drug use repeated use mifepristone levonorgestrel significant main effects estrous cycle length mrna expression protein level ovarian fshr lhr repeated mifepristone levonorgestrel use withdrawal time significant interaction mouse estrous cycle ovarian lhr fshr mrna expression protein level conclusionrepeated use mifepristone levonorgestrel lead sustained damage ovarian function inhibition ovarian fshr lhr expression mice
alcohol exposed pregnancies health issue many american indian communities goal manuscript outline existing alcohol exposed pregnancy prevention program non pregnant women project choices modified fit needs norms american indian community oglala sioux tribe choices program developed implemented using community feedback initial meetings reviewing materials gathering input recruitment intervention logistics conducting interviews evaluate program intervention implemented enrolling non pregnant american indian women past several years data collection ongoing shown preliminary success changing behaviors impacting community views prevention alcohol exposed pregnancies overall study highlights potential expand prevention program sites populations adolescents end article readers comprehend steps necessary replicate program tribal rural sites
alendronate therapy associated serious side effects altering alendronate concentration combining high frequency loading mechanical intervention explored animal study treatment osteoporosis bone anabolic potency high frequency loading overruled different alendronate dosages applied present study exploration reduced hormonal therapy associated mechanical interventions osteoporosis treatment sought aim present study investigate effect alendronate aln administration two different dosages associated high frequency loading bone microstructural response sixty four female wistar rats used ovariectomized ovx sham operated shovx ovx animals divided three groups two groups treated alendronate dosage aln reduced dosage aln three times per week third ovx group receive pharmaceutical treatment four groups mechanically stimulated via whole body vibration wbv left untreated shwbv aln administered weeks starting week post ovx tibia bone structural parameters analyzed using vivo microcomputed tomography trabecular bone loss structural deterioration resulting ovariectomy partially restored aln administration demonstrated improvement trabecular patter factor trabecular separation structure model index smi aln groups compared ovx group regardless applied dosage aln aln mechanical loading regime shwbv wbv however significant positive effect aln administration trabecular decrease smi cortical bone increase cortical thickness microarchitecture compared ovx status group observed loading regimes seen aln furthermore loading resulted cortical bone changes increased trabeculary area endocortical perimeter finally benefits combined therapy aln loading could discerned present experimental conditions bone anabolic potency loading overruled aln dosages applied present study altering aln dosage combined robust mechanical stimuli needs considered osteoporosis research eventually therapy
alert intelligent device ambient assisted living aal system allows evaluation potentially dangerous situations elderly people living alone home evaluation obtained hoc network sensor nodes working conjunction ambient intelligence layer embedded personal computer learns user behaviour patterns warns detected pattern differs significantly previously acquired normal patterns new datum read sensors processed ambient intelligence layer three processing levels shallow intermediate deep shallow processing level focuses physical data sensory features intermediate level covers information interpretation translation form required third level reasoning processing deep level alert intelligent device energy critical issue sensor devices need properly designed managed achieve significant energy saving use bed chair occupancy sensors mandatory kind ubiquitous computing system first way approach problem relied use pressure mats several environmental drawbacks showed inappropriate efficient reliable solution large volume deployments moreover solutions based force resistor transducers entail power consumption budgets keep integrated wireless sensor nodes paper force capacitive transducer based sensor proposed implemented tested sensor based electromechanical film emfi transducers able detect force variations quasi passive way kind transducer behaves capacitors variable capacitance depending force exerted surface developed new technique carry characterization transducers detection force change used trigger active mechanism allows measure weight means novel modelling approach low power wireless sensor node prototype includes new transducer assembled tested wide range weights occupancy detection achieved technology proven successful increasing total power consumption node less makes suitable implementation
algorithmic thinking development difficulty students confront learn programming right use selection control structures big challenge research used generative learning objects algorithmic thinking development programming foundations course offered new students computer systems career research methodological approach quantitative quasi experimental design applied pretest posttest obtained results determined use generative learning objects relevant
alice incredibly fun programming environment allows users manipulate objects world order create program animated movies paper discusses impact adopting alice female students attitude performance introductory computer programming course java language target population research first year computing students arab open university jordan branch quasi experiment conducted research two classes chosen one used alice class used data analysis showed using alice positive impact female students performance attitude towards computer programming
attempts aeroelastic explanations torsional instability suspension bridges somehow criticised none unanimously accepted scientific community suggest new nonlinear model suspension bridge perform numerical experiments parameters corresponding collapsed tacoma narrows bridge show thresholds instability line observed day collapse analysis enables give new explanation torsional instability based nonlinear behavior structure elsevier rights reserved
clinically used antipsychotics display similar affinity receptors likewise act hta receptor antagonists provide therapeutic benefit positive symptoms marked consistent improvement neurocognitive social cognitive negative symptoms since blockade htr receptors enhances neurocognition social cognition potentially improves negative symptoms promising approach improved treatment schizophrenia would develop drugs preferentially act versus likewise recognize htr starting high affinity htr ligands identified compounds behave htr ligands significant selectivity elsevier ltd rights reserved
interpersonal interactions underpinned action perceiving understanding actions others responding planning performing self made actions perception action self made observed informs ongoing motor responses iterative feedback within perception action loop fundamental phenomenon occurs within single cells macaque brain demonstrate sensory motor response properties mirror neurons led swathe research leading broadly accepted idea human mirror system current review examines putative human mirror system literature highlight several inconsistencies comparison seminal macaque data ongoing controversies within human focused research including mirror neuron origin function particular address often neglected side mirror complementary opposing actions propose engagement mirror system meeting changing task demands dynamically modulated via frontal control networks authors published elsevier ltd open access article license http creativecommons org licenses
allergen induced airway inflammation characterized mediated eosinophilic inflammation lungs molecular mechanisms leading abnormal response remain unclear recent studies demonstrated micrornas mirnas modulate allergic airway inflammation study role mirnas allergic asthma pathogenesis examined differentially expressed mirnas identified via mirna microarray mir among highly expressed asthma mice lungs examination mir overexpression resulted enhanced inflammation mucus hypersecretion lungs allergen challenged mice compared control animals furthermore ctla important negative regulator cell activation identified direct mir target moreover mir overexpression cells resulted decreased ctla levels subsequent increased proliferative response collectively findings suggest mir might contribute allergic asthma increasing proliferative response cells via ctla regulation thus may potential therapeutic target allergic asthma elsevier inc rights reserved
allergen specific immunotherapy accompanied multiple changes cellular humoral level shift immune responses towards immune responses type goes along increase regulatory cells cells well reduction effector cells eosinophils tissue combined lower ige production favor higher igg production regarded key mechanisms allergen specific immunotherapy better understanding immunologic pathways specific immunotherapy would essential improvement therapy well development reliable biomarkers capable monitor therapeutic responses well compliance patients
allergic rhinitis common chronic disorder characterized immunoglobulin mediated inflammation identify new genes associated trait performed genome epigenome wide association studies linked marginally significant cpgs located genes promoter snps located cpgs identifying cis methylation quantitative trait loci mqtl approach relies functional cellular aspects rather stringent statistical correction able identify one gene significant cis mqtl allergic rhinitis caudal type homeobox cdx also identified genes marginally significant cis mqtls including one allergic rhinitis without asthma rnf moreover snps identified located closest gene linked cis mqtls counting one linked cdx located gene previously associated asthma atopic dermatitis combining omics data able identify new genes associated allergic rhinitis better assess genes linked associated snps
allergies steadily gaining importance western world one hundred years immunology causal treatment specific immunotherapy sit aims cure allergy least freedom allergy symptoms association adherence poses complex problem treatment applications commonly used germany sublingual subcutaneous immunotherapy show poor persistence part patients cases sit carried end recommended duration instead discontinued prematurely corresponding figures aeuroyear studies literature range uncompleted slit uncompleted scit patient adherence subject influencing factors various dimensions interdependent complex relationships physician patient relationship decisive factor treatment success patient understanding allergy treatment importance adherence
allergy reactions common immunological diseases represent one widespread fast growing chronic human health problems among people years age developed countries populations get older worldwide allergy manifestations aged persons occur often future date much studies allergies children adults population ages clinicians must prepared meet elderly health care needs including new emerging health issue allergic diseases represent old new emerging health issue many common illnesses masquerade atopic disease differential diagnosis suspected allergic diseases becomes expanded aging population research field needs focus human animal model systems investigate
allocating memory dynamically virtual machines vms according demands provides significant benefits well great challenges efficient memory resource management requires knowledge memory demands applications systems runtime widely proposed approach construct miss ratio curve mrc summarizes current working set size wss also models relationship performance target memory allocation size unfortunately cost monitoring maintaining mrc structures nontrivial article first introduces low cost wss tracking system effective optimizations data structures well efficient mechanism decrease frequency monitoring also propose memory balancer meb dynamically reallocates guest memory based predicted wss experimental results show prediction schemes yield high accuracy low overhead furthermore overall system throughput significantly improved meb brings speedup two four vms overcommitted system vms
allogeneic hematopoietic stem cell transplantation allo sct therapeutic option relapsed advanced otherwise incurable non hodgkin lymphomas nhl suggested existence graft versus lymphoma effect main complications graft versus host disease infections performed retrospective analysis patients nhl received allo sct january december parameters impact overall survival age aecurrency years old chemosensitive disease pre allo sct indolent nhl histology parameters impact progression free survival age aecurrency years old chemosensitive disease pre allo sct aggressive nhl histology refractory disease pre allo sct showed increased risk death multivariate model use allo sct young patients multiple relapsed chemosensitive indolent nhl suitable option despite poor prognosis young aggressive nhl patients considered allo sct provided chemosensitive disease
along development human environmental problems attracted attention green become main trend century green action important department decisive factor country enterprise take part competition world market based analysis important mode modern enterprise propose green idea management supply system construct green supply management reduce resource cost environmental affect study green supply estimate performance high accuracy great importance furthermore high quality performance evaluation may let enterprise answer questions discover solutions enhance quality operation improvement green supply therefore crucial enhance green supply making performance evaluation high accuracy paper study multiple attribute decision making problems estimate performance green supply chain based environmental economics fuzzy information developed fuzzy hamacher correlated averaging fhca operator exploited fhca operator multiple attribute decision making estimate wireless network security fuzzy information end example estimate performance green supply chain based environmental economics proposed prove effectiveness proposed approach
alpha synuclein misfolding aggregation hallmark parkinson disease several neurodegenerative diseases known synucleinopathies toxic properties alpha synuclein conserved yeast man precise underpinnings cellular pathologies associated still elusive complicating development effective therapeutic strategies combining molecular genetics target based approaches established glycation unavoidable age associated post translational modification enhanced alpha synuclein toxicity vitro vivo drosophila mice glycation affected primarily terminal region alpha synuclein reducing membrane binding impaired clearance alpha synuclein promoted accumulation toxic oligomers impaired neuronal synaptic transmission strikingly using glycation inhibitors demonstrated normal clearance alpha synuclein established aggregation reduced motor phenotypes drosophila alleviated altogether study demonstrates glycation constitutes novel drug target explored synucleinopathies well neurodegenerative conditions
alterations motor functions well characterized features observed humans experimental animals thyroid hormone dysfunctions development previously suggested implication endocannabinoid system hyperlocomotor phenotype observed developmentally induced hypothyroidism rats work analyzed implication endocannabinoids effect hypothyroidism locomotor activity end evaluated locomotor activity adult mice lacking cannabinoid receptor type cbr wild type littermates cbr whose hypothyroidism induced day gestation maintained experimental period results show hypothyroidism induced hyperlocomotor phenotype cbr cbr mice contrast previous results rats expression cbr striatum motor response cannabinoid agonist unaltered hypo thyroid cbr mice suggesting cannabinoid system altered hypothyroidism also effect observed locomotion cbr mice finally since dopaminergic system plays major role control locomotor activity studied function hypothyroid wild type knockout animals results show alteration behavioral response induced dopamine receptor agonist skf however observed decreased response dopamine receptor antagonist haloperidol hypothyroid cbr mice might indicate potential alterations signaling animals conclusion data suggest cannabinoid system necessary induction hyperlocomotor phenotype mice developmentally induced hypothyroidism elsevier ltd rights reserved
although lot research attention already devoted personality emotional basis right wing attitudes racial prejudice relationships trait emotional intelligence latter variables largely neglected present study conducted heterogeneous sample adults aim fill gap literature revealed trait negatively related right wing authoritarianism social dominance orientation subtle racial prejudice relationships partly explained empathy specifically component perspective taking trait negatively related ability take perspective others turn associated increased right wing attitudes subtle racial prejudice elsevier ltd rights reserved
although abundant research documented positive interpersonal outcomes perspective taking growing body evidence indicates perspective taking also induce negative interpersonal outcomesin words backfires aim integrating seemingly contradictory findings suggesting perspective taking backfires causes perspective taking individual feel threatened threat emerge act perspective taking target perspective taking perceived different self adopting another perspective creates potential negative self evaluation furthermore threat may emerge perspective taking successfully creates perceptions self overlap overlapping characteristics accentuate potentially threatening characteristics target theoretical model affords predictions conditions perspective taking linked self threat may backfire
although antisocial personality disorder aspd represented current operationalization psychopathy since dsm iii long recognized failing capture full range construct current study examined degree boldness trait domain within triarchic conceptualization psychopathy captures fearlessness dominance low stress reactivity represents distinct difference psychopathy aspd utilizing sample male prison inmates current study examined extent boldness relative meanness disinhibition indexed triarchic psychopathy measure tripm accounted incremental variance beyond aspd symptom counts indexed structured clinical interview dsm axis disorders aspd module predicting psychopathy indexed psychopathy checklist revised pcl total factor facets scores tripm boldness added incremental prediction pcl factor interpersonal affective facet interpersonal scores beyond aspd scores
although aplastic anemia myelodysplastic syndrome mds separate entities different management distinction two difficult morphological basis due hypocellularity bone marrow mds one serious complications karyotyping definitive diagnosis mds better robust investigations like fluoro deoxy glucose positron emission tomography computed tomography fdg pet essential high risk patients haematological malignancies relapsing within short period time initiation therapy refractory disease might helpful development individual treatment algorithms high risk patients may unique problems hematological malignancies transformation one pathology another may silent biomarkers predict transformation transformation mds studies shown immune suppression lead variety haematological lymphoproliferative disorders may exist fdg pet may useful identifying primary occult sites malignancy also direct site biopsy attempted present patient carcinoma right breast developed hematological lymphoproliferative disorders course treatment case transformed mds abnormal karyotype chromosome mutation progressed manifest cutaneous cell lymphoma patient succumbed illness immune mediated suppression haemopoiesis considered important mechanism case
although appearance based cues help diagnose physical illness visual manifestations mental disorder may elusive investigated whether individuals could distinguish women serious mental disorder borderline personality disorder demographically matched non psychiatric controls participants rated mentally ill targets likely mental disorder photos accurately chance despite believing judgments possible configuration facial cues played important role judgments interfering spatial relationships facial features reduced participants accuracy chance guessing investigation showed similar results participants rated targets specific mental disorders borderline personality disorder major depressive disorder rated mentally ill targets depressed angry anxious disgusted emotionally unstable distressed less happy moreover depression ratings significantly correlated targets actual depressive symptoms thus individuals may able infer aspects mental disorder minimal facial cues
although bcr abl hallmark genetic abnormality chronic myeloid leukemia cml secondary molecular events responsible evolution disease blast crisis yet deciphered taking account significant association ecotropic viral integration site evi cml drug resistance necessary decipher roles played evi cml disease progression regard cross hybridized three microarray datasets deduced set genes seems regulated evi cml observed strong correlation evi alpha fucosyltransferase fut chronic phase disease found regulated progression disease knockdown evi cml cell line regulated fut also rendered cells towards erythroid differentiation study shows involvement evi fut axis blocking erythropoiesis cml
although benevolent sexism ideology highly reveres women conform traditional gender roles cloaked superficially positive tone placed upon pedestal inherently restrictive accordingly paternalistic beliefs associated based idealization traditional gender roles include motherhood predict people attitudes toward women reproductive rights using data nationwide longitudinal panel study study showed hostile sexism cross lagged effects opposition elective traumatic abortion study extended findings showing relationship support abortion fully mediated attitudes toward motherhood results highlight pernicious nature demonstrating idealization women motherhood particular comes substantial cost namely restriction women reproductive rights
although cigarette smoking leading cause preventable mortality tobacco consumed approximately adult population worldwide smoking also risk factor cardiovascular disease affects brain processing recognized risk factor alzheimer disease tobacco toxins nicotine high levels inhaled smoke may cause disorders resulting preclinical brain changes researchers suggest differences brain volume smokers non smokers review examines differences brain grey matter volume gmv march april medline embase psycinfo searched using terms grey matter voxel based smoking cigarette studies analyzed found brain gmv decreases smokers compared non smokers furthermore sex specific differences found thalamus cerebellum affected sexes decreased gmv olfactory gyrus found male smokers age group differences also found may suggest pre existing abnormalities lead nicotine dependence younger individuals study found positive correlation number pack years smoked gmv smoking decreases gmv brain areas decrease may responsible cognitive impairment difficulties emotional regulation found smokers compared non smokers
although detection deception accuracy rate researched extensively person perception components basis judgments remain unclear explore academics person perceptions well truthfulness judgment individual presenting televised appeal measured using item scale twelve appeals genuine false information regarding whereabouts missing relative information apprehend person murdered relative used person perception scale consisted global abstract judgments open deceptive genuine trustworthy emotional behavioural indices facial pleasantness facial animation arousal tension involvement verbal consistency plausibility directness vocal certainty multiple regression identified person perceptions openness non deceptiveness genuineness trustworthiness verbal plausibility significant predictors truthfulness judgments future research explore relationship person perception components truth judgments accuracy
although hormones play fundamental roles prostate growth clinical significance completely clear aims present study assess whether testosterone serum sex hormone levels predictors benign prostatic hyperplasia bph prostate cancer verify whether prostate cancer associated low testosterone levels test association testosterone levels known prognostic factors prostate cancer consecutive patients benign prostatic hyperplasia prostate cancer testosterone follicle stimulating hormone luteinizing hormone prolactin levels tested correlated disease patients prostate cancer hormone levels also correlated known prognostic factors predictive value assessed age prostate specific antigen psa psa ratio psa density prostate volume serum sex hormone levels using multiple logistic regression analysis receiver operating characteristic curves considering sex hormones testosterone levels significantly lower patients prostate cancer bph testosterone levels appear independent predictor prostate cancer enhancing predictive accuracy bph testosterone levels seem associated known clinical prognostic factors study supports experimental findings testosterone levels predictor prostate cancer prostate cancer frequently associated low testosterone levels diagnostic work prostate cancer adding testosterone determination psa test may improve predictive accuracy
although improvements materials engineering greatly reduced fracture rates ceramic femoral heads concerns still exist liners ceramics vulnerable fracture due impact stress concentrations point line loading associated impingement subluxation thus ceramic cup fracture propensity presumably sensitive surgical cup positioning novel fracture mechanics finite element formulation developed identify cup orientations susceptible liner fracture propagation several impingement prone patient maneuvers factors equal increased cup inclination increased anteversion found elevate fracture risk squatting stooping leaning shoe tie maneuvers associated highest fracture risk results suggest fracture risk reduced surgeons decreasing cup abduction patients avoiding specific activities
although affects population stage chronic kidney disease ckd increased prevalence united states grown early first part decade important consider new strategies slow halt increase frameshift patient care delivery underway kidney health care united states medicare education benefit patients stage ckd medicare benefit unique program potential inform patients families ckd prepare transitions health states kidney health care greatest value benefit realized critical health care community accurately gauge patient understanding ckd provide curricula comprehensible actionable patients type benefit patient centered yet succeed willingness review effectiveness revise needed kidney dis national kidney foundation inc
although loving kindness meditation lkm shown promise psychological intervention little known effectiveness lkm reducing one prevalent mental health problems anxiety build knowledge area conducted randomized controlled trial assigning non clinical undergraduates either four session group based lkm intervention waitlist control self reported anxiety compassionate love self compassion assessed pretreatment posttreatment week follow relative control participants participants lkm intervention reported higher compassionate love self compassion posttreatment higher self kindness component self compassion follow anxiety ratings significantly differ conditions posttreatment follow study limitations directions future research discussed
although many scholars argued leadership dynamic process jointly produced leaders followers leadership sports often researched unidirectional process coaches athletes within self determination theory sdt individual characteristics suggested influence people perceive external events coaches behaviors present study examined jointly produced leadership process investigating longitudinal associations athletes controlled motivation ill perceptions coaches controlling behaviors within person levels participants young elite skiers enrolled swedish sport high schools responded self report questionnaires three time points course athletic season person level increases perceptions coaches controlling behaviors season positively predicted controlled motivation end season controlled motivation beginning season positively predicted ill end season within person level athletes controlled motivation positively predicted perceptions coaches controlling behaviors results person level support unidirectional perspective tenets sdt results within person level suggest individual characteristics motivation influence athletes perceive external events proposed theoretically seldom examined empirically three plausible explanations reversed association presented discussion elsevier ltd rights reserved
although malaysians taking part international multisport games athletes well events fully explored purpose study examine pattern injury illness among malaysian athletes xvii asian games clinical socio demographic information athletes diagnosed injury illness centralised training camp games recorded standardised report form throughout study period injuries illnesses recorded athletes muscle strains tears common injury followed ligamentous injury soft tissues contusion number injuries highest among badminton players followed hockey rugby significantly higher incidence injuries observed among men women hockey players athletes individual events higher proportion severe injury team events respiratory tract infection frequent illness diagnosed among athletes injuries illnesses diagnosed among athletes minor result time away participation incidence injuries illnesses among malaysian athletes xvii asian games comparable reported previous authors injury illness rate influenced gender sports fortunately majority injuries illnesses minor prevent athletes participation
although multi label learning deal many problems label ambiguity fit real applications well overall distribution importance labels matters paper proposes novel learning paradigm named label distribution learning ldl kind applications label distribution covers certain number labels representing degree label describes instance ldl general learning framework includes single label multi label learning special cases paper proposes six working ldl algorithms three ways problem transformation algorithm adaptation specialized algorithm design order compare performance ldl algorithms six representative diverse evaluation measures selected via clustering analysis first batch label distribution datasets collected made publicly available experimental results one artificial real world datasets show clear advantages specialized algorithms indicates importance special design characteristics ldl problem
although nearly countries world taken active measures mitigate greenhouse effect primary cause extreme climate change electric motor accounts total global electricity consumption thus becoming primary appliance requiring high efficiency standards report survey conducted high efficiency motor promotion cases taiwan developed countries furthermore comparison policy technology regulatory trend aspects summarized conclude research technical development brushless motors popular program motor industry permanent magnet synchronous motors essentially welcome product market corresponding items include optimization motor design electromagnetic enhancement silicon steel sheets promotion advantages permanent magnetic field modification wire winding technology improvements electronic control technology described end report suggested policies development high efficiency motors applicable taiwan well countries energy saving carbon reduction issues well approach high energy price era led rapid development popularization high efficiency motors elsevier ltd rights reserved
although objectification theory suggests women frequently experience objectifying gaze many adverse consequences scant research examining nature causes objectifying gaze perceivers main purpose work examine objectifying gaze toward women via eye tracking technology secondary purpose examine impact body shape objectifying gaze elicit gaze asked participants women men large midwestern university focus appearance personality women presented women body shapes fit cultural ideals feminine attractiveness varying degrees including high ideal hourglass shaped women large breasts small waist hip ratios average ideal average breasts average waist hip ratios low ideal small breasts large waist hip ratios consistent main hypothesis found participants focused women chests waists faces less appearance focused personality focused moreover found effect particularly pronounced women high average low ideal body shapes line hypotheses finally compared female participants male participants showed increased tendency initially exhibit objectifying gaze regarded women high average low ideal body shapes positively regardless whether appearance focused personality focused implications objectification person perception theories discussed
although people history child abuse known elevated risk later difficulties relationships debate whether effects enduring relatively immutable moderated characteristics behaviors partner reconcile competing perspectives conducted longitudinal study newlywed couples living low income neighborhoods testing whether association abuse history relationship satisfaction dependent partners aggression depression substance abuse observed communication demographic risk factors spouses abused children husbands wives reported symptoms depression substance abuse among husbands displayed negative communication spouses history child abuse also less satisfied marriage even newlyweds abused wives also declined satisfaction time compared without history however interactions abuse history proposed moderators significant indicating partner relationship characteristics failed strengthen weaken association abuse history relationship satisfaction childhood experiences abuse appear lasting broad effects individual relational outcomes effects neither heightened mitigated partner characteristics behaviors
although piezoelectric transducers employed variety fields application vibration control civil industrial structures yet fully developed best authors knowledge thanks new generation ever performing piezoceramic materials recent development scientific proposals based simple technology paper presents step forward engineering applications control structural systems three hinged arch controlled piezoelectric stack actuators passive electrical circuits chosen simple structural model may represent starting point generalization common typologies civil industrial engineering structures based concept electromechanical analogy evolution equations obtained consistent lagrangian approach multimodal vibration suppression guaranteed spectral analogy mechanical electrical components preliminary applications related free oscillations one actuators member seem lead excellent performance terms multimodal damping dissipated energy
although postpartum depression ppd symptoms fairly common among new mothers fathers new parents still perceive stigma associated baby blues research extensively examined role perceived stigma help seeking clinical ppd little known process perceived stigma new parents examined role perceived stigma postpartum depressive symptoms using dual pathway model mickelson williams specifically tested whether internalized stigma would influence ppd symptoms parenting efficacy whereas experienced stigma would influence ppd symptoms indirect support seeking also examined whether internalized pathway stronger fathers mothers would utilize pathways using longitudinal data community sample first time parents united states found parenting efficacy mediator internalized stigma ppd symptoms mothers experienced stigma ppd symptoms fathers indirect support seeking cross sectional mediator mothers internalized stigma ppd symptoms understanding new mothers fathers perceive stigma attached ppd symptoms process impacts symptom reporting help improve interventions aimed new parents
although probabilistic risk analysis methods available engineering construction practitioners decades use pervasive industry today determine use prevalent research team conducted depth interviews administered survey questionnaires analysis data identified benefits barriers employing probabilistic risk analysis engineering managers implement formal project risk management approaches exploiting benefits training employees adopting processes procedures risk management regularly communicating results probabilistic analysis project stakeholders
although recent work suggests opposite sex facial attractiveness less salient memory individuals committed romantic relationship romantic relationship quality vary time light tested whether activating concerns romantic relationship quality strengthens memory attractive faces partnered women exposed briefly faces manipulated shape cues attractiveness either asked think moment emotional closeness distance current relationship measured sensitivity memory faces extent recognized correct versions studied faces versions person altered look either less attractive original studied version contrary predictions high relationship quality strengthened hit rate faces regardless sex attractiveness face general women memories sensitive attractiveness women biased toward attractiveness male faces responding unfamiliar faces versions familiar faces attractive original male identity learning phase however findings varied according self rated attractiveness psychometric measure quality current relationship attractive women sensitive attractiveness men less attractive peers stronger bias remember women attractive men less attractive original image respectively women better quality romantic relationships stronger positive biases toward false memories attractive men findings suggest sophisticated pattern sensitivity bias women memory facial cues quality varies systematically according factors may alter costs female mating competition market demand relationship maintenance elsevier rights reserved
although relationship restoration important outcome forgiveness little known forgiveness facilitates outcome addition forgiveness research little attention paid perspective offender address two shortcomings simultaneously testing idea forgiveness promotes offender gratitude turn encourages offender pro relational intentions across three experimental studies participants induced believe transgressed recalled time transgressed imagined transgressing studies forgiveness manipulated study victim motivation forgiving manipulated state gratitude comparison guilt indebtedness positive affect consistently found play primary mediating role forgiveness pro relational intentions
although second hand smoke shs exposure associated asthma effect eczema unclear especially effect maternal passive smoking childhood eczema rarely studied polymorphisms tumor necrosis factor alpha tnf alpha toll like receptor tlr glutathione transferase gstp genes interact air pollutants modify allergic disease development study aimed investigate effect gene environment interactions shs exposure tnf alpha tlr gstp polymorphisms childhood eczema children aged years enrolled followed years later details shs exposure eczema collected questionnaires tnf alpha tlr gstp genotypes determined maternal passive smoking pregnancy associated increased prevalence eczema diagnosis ever adjusted odds ratio aor confidence intervals eczema symptoms past months aor persistent shs exposure prenatal period present associated increased prevalence eczema diagnosis ever aor maternal passive smoking pregnancy persistent shs exposure associated increased risk new eczema diagnosis children tnf alpha aor maternal passive smoking pregnancy aor persistent shs exposure tlr aor maternal passive smoking pregnancy aor persistent shs exposure gstp aor maternal passive smoking pregnancy aor persistent shs exposure genotypes interactions shs tnf alpha tlr gstp polymorphisms may affect childhood eczema development reducing shs exposure prenatal period may prevent childhood eczema susceptible populations
although understanding post reproductive life dates back ancient greece term menopause introduced early french physician notwithstanding familiarity condition time treatments largely ineffective often harmful never evidence based years later identification description estrogen progesterone effective treatments became available efficacious hormone therapies menopausal symptoms prescription often recommended postmenopausal women regardless needs wishes health status many benefit harm environment small group clinicians determined form international menopause society ims conduct research appropriate use hormone therapy treating menopause symptoms hold regular congresses educate colleagues discuss research results thus improve health well women midlife beyond formed ims recognized global leader field working towards goals collaboration colleagues national regional societies concerned women health time ims led presidents conducted world congresses menopause reviewed paper
although stereotypes traditionally regarded stable research documented considerable malleability one potential source malleability intrusion stereotype concepts also activated stereotype activated three experiments assessed extent stereotypes influenced stereotypic stereotype unrelated counter stereotypic traits activated completely unrelated context immediately prior stereotype measurement across experiments priming stereotype unrelated traits increased inclusion stereotype whereas priming counter stereotypic traits effect subsequently assessed stereotype experiment collected perceived dispersion measures showed although priming counter stereotypic traits effect overall characterization target group boosted perceptions group variability accounted results extending higgins synapse model knowledge accessibility stereotype domain elsevier inc rights reserved
although subungual squamous cell carcinoma rare common primary malignant neoplasms location higher incidence occurs fingernails involvement toenails also possible subungual squamous cell carcinoma often looks like common benign lesions fungal infection onychomycosis viral wart factors together general lack awareness disease among physicians often result delayed diagnosis therefore underdiagnosed reports literature authors present case man diagnosis subungual squamous cell carcinoma hallux without bone involvement submitted appropriate surgical treatment
although classical pid proportional integral derivative controller widely successfully used engineering systems typically nonlinear various uncertainties almost existing investigations pid controller focus linear systems aim paper present theory pid controller nonlinear uncertain systems giving simple analytic design method pid parameters together mathematic proof global stability asymptotic regulation closed loop control systems specific construct dimensional manifold within three pid parameters chosen arbitrarily globally stabilize wide class second order nonlinear uncertain dynamical systems long knowledge upper bound derivatives nonlinear uncertain function available also try make feedback gains small possible investigating necessity manifold pid parameters chosen establish necessary sufficient conditions global stabilization several special classes nonlinear uncertain systems
although effects habitat size shape ecological processes well studied importance habitat orientation geometrical feature habitat placement describes habitat placed space largely overlooked decades varied orientation cuboid chambers correspondingly small medium large sides chamber base microcosm experiment involving phytoplankton zooplankton chlorella pyrenoidosa ceriodaphnia quadrangula system two volume scales determine effect habitat orientation swimming activity grazing rate quadrangula given chamber volume grazers spent time swimming vertically swam slower particularly horizontal direction tall small based chamber compared short large based ones moreover grazing rates quadrangula significantly lower tall chambers short ones regardless experimental time consistent positive relationship average swimming velocity grazing rate data indicate habitat orientation may affect animal activity foraging success therefore suggest habitat orientation deserves much attention future studies
although hiv pandemic witnessing decline number new infections regions world middle east north africa mena rapidly growing hiv problem generating hiv data consistently increasing since mena contribution global hiv literature existing evidence often falls behind academic standards several factors could play contribute limited quantity quality hiv data mena editorial tries explore explain barriers collecting high quality hiv data generating precise estimates mena barriers include number logistic socio political challenges faced researchers public health officials policy makers looking successful regional hiv programs explore examples policies shifted lessons could learned developing appropriate responses hiv across region
although processes underlie sharing others emotions empathy understanding others mental states mentalizing theory mind received increasing attention yet unclear relate instance people strongly empathize others also proficient mentalizing neural networks supporting empathy mentalizing interact assessing functions simultaneously large sample show people capacities empathize mentalize independent behavioral neural level thus strong empathizers necessarily proficient mentalizers arguing general capacity social understanding second applied dynamic causal modeling investigate neural networks underlying empathy mentalizing orchestrated naturalistic social settings results reveal highly emotional situations empathic sharing inhibit mentalizing related activity thereby harm mentalizing performance taken together findings speak unitary construct social understanding suggest flexible interplay distinct social functions
although role social cognition leadership perception emphasized frequently recent years research using approach organizational context rare study investigated subordinates perceptions managers leaders extent perceive manager leader potential mediating factor explaining relationship managers self monitoring subordinates attitudes toward organizations study carried middle level managers subordinates various business organizations turkey results indicate subordinates leadership perceptions managers mediate relationship managers self monitoring subordinates affective normative organizational commitment results provide insight antecedents outcomes leadership perception
although utilisation fungal biological control agents kill insect pests desirable known outcome infection may influenced number criteria including whether target insect stressed current work topical treatment larvae lepidopteran pest mamestra brassicae conidia beauveria bassiana followed heat stress degrees later resulted similar level larval survival occurring heat stress fungus treated larvae contrast applied fungal treatment larval survival significantly increased indicating protecting larvae bassiana similarly exposure larvae provided protection metarhizium brunneum fungal treatment elucidate mechanism might contribute induced increases larval survival fungal infection effects key cellular humoral immune responses level selected heat shock proteins hsp assessed larvae kept control conditions significant difference haemocyte number per haemolymph period however exposure larvae significantly increased haemocyte density immediately compared controls whilst returned control levels addition vitro assays indicated haemocytes harvested larvae immediately exhibited higher rates phagocytosis fitc labelled bassiana conidia compared haemocytes harvested non larvae interestingly appear increase anti fungal activity larval plasma western blot analysis using antibodies cross react drosophila melanogaster hsp resulted relatively strong signal hsp hsp extracts haemocytes respectively harvested larvae contrast hsp lysate derived haemocytes resulted relatively weak signal larvae exposed level three hsp increased compared control however treatment heat stress mediated increase hsp levels minimal consistently detected similar results obtained hsp levels assessed fat body harvested heat stressed non heat stressed larvae regard hsp signal obtained even lysate haemocytes three times amount fat body processed suggesting anti hsp antibody utilised cross react brassicae hsp results suggest mediated increase haemocyte density phagocytic activity together upregulation hsp may contribute increasing survival brassicae larvae treated bassiana brunneum elsevier ltd rights reserved
although theory research evidence indicate less securely attached persons likely secure peers experience emotion regulation difficulties necessarily pre ordained outcome emotion regulation difficulties may proximally predicted individuals maladaptive psychological defenses humor styles study explored interrelationships adult attachment orientations attachment anxiety avoidance perceived bonds parents perceived levels parental care control emotion regulation cognitive reappraisal expressive suppression maladaptive humor styles aggressive self defeating humor attachment anxiety avoidance maternal care overprotection associated expected directions aggressive self defeating humor paternal care overprotection additionally aggressive self defeating humor positively associated expressive suppression negatively associated cognitive reappraisal self defeating humor partially mediated relationship number attachment predictors attachment anxiety avoidance maternal care maternal control expressive suppression example attachment anxiety predicted higher use self defeating humor turn predicted higher levels expressive suppression finally aggressive humor partially mediated relationship avoidance cognitive reappraisal avoidance predicted higher use aggressive humor turn predicted lower levels reappraisal implications future research clinical practice discussed
although considerable research investigating ability identify sexual orientation static images gaydar studies considered role female sexual orientation sexual interest example sociosexual orientation judgment accuracy two studies investigated sexuality detection ability masculinity femininity cues used judgment study recruited heterosexual homosexual women rate sexual orientation homosexual heterosexual male female targets heterosexual men homosexual men heterosexual women homosexual women found detection accuracy better chance levels male female targets male targets likely falsely labeled homosexual female targets overall female faces accurately identified heterosexual homosexual male faces homosexual female raters biased towards labeling targets homosexual sociosexuality influence accuracy targets identified heterosexual homosexual study heterosexual homosexual women rated stimulus masculinity femininity heterosexual women rated feminine less masculine homosexual women homosexual men rated feminine less masculine heterosexual men sexual orientation judges affect ratings results discussed reference evolutionary cultural influences affecting sexual orientation judgment accuracy
although tremor common movement disorder exist effective tremor suppressing devices part characteristics tremor throughout upper limb unknown clarify optimally suppressing tremor requires knowledge mechanical origin propagation distribution tremor throughout upper limb present first systematic investigation tremor propagates shoulder elbow forearm wrist simulated tremor propagation using linear time invariant lumped parameter model relating joint torques resulting joint displacements model focused seven main degrees freedom shoulder wrist included coupled joint inertia damping stiffness deliberately implemented simple model focus first basic effects simulating tremorogenic joint torque sinusoidal input used model establish fundamental principles describing input parameters torque location frequency joint impedance inertia damping stiffness affect tremor propagation expect methods principles presented serve groundwork future refining studies understand origin propagation distribution tremor throughout upper limb order enable future development optimal tremor suppressing devices
although universal screening mental health difficulties increasingly recognized way identify children risk provide early intervention little research exists inform decisions screening choice informants type information collected present study examined incremental validity teacher parent rated primarily mothers symptoms impairment non referred sample early elementary school children boys ages terms predicting impairment rated different teacher year later teacher rated symptoms impairment parent rated impairment unique predictors later impairment however parent rated symptoms contribute prediction later impairment beyond indicators results indicate screening mental health difficulties school system impairment ratings collected across settings add useful information may necessary use parent symptom ratings teacher symptom ratings available
although women representation higher education nears parity men undergraduate level representation diminishes one ascends academic ranks gender gaps elite activity international research collaborations might contribute underrepresentation women upper ranks ask gender differences exist participation international collaborations family responsibilities constitute glass fence gendered obstacle keeps women engagement using international data set find women engage less international collaborations men complex gendered patterns exist regarding impacts partner employment status children men women benefit academic partner although men benefit partner employment status matters children certain family arrangements suggesting former constitutes glass fence potentially impacting women access cutting edge international knowledge production elite academic positions
aluminium matrix composites find wide applications present industrial scenario due desirable properties study effect process parameters machinability aluminium matrix composites paramount importance field manufacturing engineering machining composite depends properties relative content reinforcement matrix materials well response machining process article investigations machinability aspects aluminium silicon carbide aluminium graphite composites presented experiments carried design experiments technique regression machinability models developed express degree resultant force depends upon cutting parameters percentage reinforcement present aluminium matrix composites machined comparative study effect cutting parameters resultant force presented
aluminum associated etiology many neurodegenerative diseases specially alzheimer disease chronic exposure aluminum via drinking water results aluminum deposition brain leads cognitive deficits study aimed determine effects aluminum cholinergic biomarkers acetylcholine level free choline level choline acetyltransferase gene expression cholinergic deficit affects novel object recognition sociability mice mice treated alcl acetylcholine level free choline level choline acetyltransferase gene expression determined cortex hippocampus amygdala mice subjected behavior tests novel object recognition social novelty preference assess memory deficits acetylcholine level cortex hippocampus significantly reduced aluminum treated animals compared cortex hippocampus control animals acetylcholine level amygdala aluminum treated animals remained unchanged free choline level three brain parts found unaltered aluminum treated mice novel object recognition memory severely impaired aluminum treated mice compared control group similarly animals treated aluminum showed reduced sociability compared control mice group study demonstrates aluminum exposure via drinking water causes reduced acetylcholine synthesis spite normal free choline availability deficit caused reduced recycling acetylcholine due lower choline acetyltransferase level cholinergic hypofunction leads cognitive memory deficits moreover hippocampus affected brain part aluminum intoxication
aluminum one toxic metals causing variety neurologic diseases especially alzheimer disease impossible avoid contact aluminum existence food medications therefore removal aluminum blood wastewater urgently important cost effective easy prepare adsorbents needed get efficient aluminum removal purpose poly hydroxyethylmethacrylate acrylic acid poly hema microparticles synthesized remove aluminum short interaction time achievement desired polymeric structure confirmed via fourier transform infrared spectroscopy ftir scanning electron microscope sem transmission electron microscope tem etc additionally particle features swelling ratio size surface area determined microparticles synthesized study determined good adsorption capacity even small aluminum concentrations
alveolarization humans nonhuman primates begins prenatal development advances stereological counting techniques allow accurate assessment alveolar number however techniques applied developing human lung based recent american thoracic society guidelines stereology lungs human autopsies ages fractionated isometric uniform randomly sampled count number alveoli number alveoli compared age weight height well growth right left lungs number alveoli human lung increased exponentially first life continued increase albeit reduced rate adolescence alveolar numbers also correlated indirect radial alveolar count technique growth curves human alveolarization compared using historical data nonhuman primates rats alveolar growth rate nonhuman primates nearly identical human growth curve rats significantly different showing pronounced exponential growth first days life evidence indicates human lung may plastic originally thought alveolarization occurring well adolescence first days life rats implies growth curve may relate prenatal growth humans data suggest nonhuman primates better laboratory model studies human postnatal lung growth rats
alzheimer disease leading cause dementia elderly characterized progressive cognitive memory deficits pathological hallmarks include extracellular senile plaques intracellular neurofibrillary tangles although several mechanisms used explain underlying pathogenesis current treatment regimens remain inadequate neuroprotective effects polyphenolic stilbene resveratrol trihydroxy trans stilbene investigated several vitro vivo models current review discusses multiple potential mechanisms action resveratrol pathobiology moreover due limited pharmacokinetic parameters resveratrol multiple strategies aimed increasing bioavailability resveratrol also addressed
alzheimer disease common neurodegenerative disease influenced genetic environmental factors brain derived neurotrophic factor bdnf plays important role progression genetic association bdnf remains controversial study aimed explore potential association genetic variants bdnf han chinese investigate whether association affected gender stage study conducted evaluate genetic association bdnf data mining reported expression data brainimaging data biomarker data patients also performed validate results found female specific genetic association gender related messenger rna expression bdnf brain tissues patients addition observed clear female specific risk trend effect endophenotypes results clarified available controversies regarding role indicated bdnf may female specific risk gene elsevier inc rights reserved
alzheimer disease progressive neurodegenerative disorder characterized accumulation neurotoxic beta amyloid beta peptides consequently affects cognitive decline memory impairment current research treatment actively focusing prevention neurotoxic beta peptide accumulation monsonia angustifolia reported consumed indigenous vegetable tanzania study investigated effect ethanol etoh extract angustifolia dried ground material beta production spatial learning ability protection formation beta peptides significantly reduced hela cells stably transfected swedish mutant form beta amyloid precursor protein appsw treatment etoh extract angustifolia next examined cognitive improving effects etoh extract vivo mice treated extract months subjected morris water maze novel object recognition tests results showed etoh extract angustifolia significantly ameliorated behavioral deficits transgenic mice reduced level insoluble beta cerebral cortex hippocampus found etoh extract effective memory function recovery shorter treatment months addition isolated identified several single compounds justicidin methoxyjusticidin chinensinaphthol retrochinensinaphthol methyl ether suchilactone angustifolia tested compounds among justicidin potently decreased formation beta appsw transfected cells data suggest etoh extract angustifolia potential developed treatment furthermore justicidin may contribute least partially beta alteration observed extract treatment
alzheimer disease common neurodegenerative disorder one factors promotes neurodegeneration accumulation senile plaques formed beta peptide paper analyzed oxidative stress cause consequence amyloid cascade role antioxidant defense system process using cerevisiae multicopy plasmid containing beta sequence experimental model cells grown glycerol tolerant grown glucose strengthening role antioxidant defense system beta accumulation antioxidant defense deficiency change pattern amyloid aggregation hand presence beta increased level intracellular oxidation induced activity catalase superoxide dismutase aconitase peroxissomal catalase deficient cells delta cta sensitive beta toxicity wild type strain mitochondrial superoxide dismutase sod deficient cells displayed highest frequency petites besides beta alters oxygen consumption activity complex iii taken together results point beta toxicity mechanism involves oxidative stress induction increasing ros production mitochondria cta sod play crucial role regulation redox balance wiley periodicals inc
alzheimer disease leading cause dementia characterized presence extensive plaque deposition neurofibrillary pathology aim present study make update regarding influence estrogens serms inflammation resolution inflammation respectively focusing important features implicated pathophysiology several hypothesised mechanisms action estrogens serm exposed also relevant clinical studies subject analysed analyzed studies high heterogeneity preparations used administration routes female population included periods time appearance induction menopause therapeutic intervention also follow periods patients means evaluating cognitive decline one say ways pharmacological influence membrane intracellular signalling system associated estrogens may clinical importance prevention possibly treatment exhausted estrogens selective era protein coupled estrogen receptors gper gqmer effects could used influence resolution inflammation process positive effects evolution
ambient intelligence ami provides vision information society heterogeneous hardware entities disseminated environment used intelligent agents provide ubiquitous applications ease integration new entities system application underlying hardware infrastructure decorrelated aim research work propose mechanisms deployment automatic configuration monitoring applications heterogeneous hardware infrastructure paper model ambient systems fulfill purpose propose graph based mathematical model ambient systems model allows use projection algorithm extending existing graph matching algorithm deployment automatic configuration applications heterogeneous hardware infrastructure authors published elsevier open access article license http creativecommons org licenses
ambient intelligence advanced significantly last years incorporation image processing artificial intelligence techniques opened possibility aspects pattern recognition thus allowing better adaptation systems study presents new model embedded agent especially designed implemented sensing devices resource constraints new model agent integrated within pangea platform automatic construction organiztions intelligent agents platform organizational based platform defining new sensor role system aimed providing contextual information interacting environment case study developed pangea platform designed using different agents sensors responsible providing user support home event incidents emergencies system presented case study incorporates agents arduino hardware devices recognition modules illuminated bands also incorporates cameras programmed automatic tracking connect remotely event emergencies user wears bracelet contains simple vibration sensor receive notifications emergency situation
ambient intelligence emerged lately integrating concept includes ubiquitous computing ubiquitous communication intelligent user interfaces real implementation concepts based use new technology innovative ways development agent oriented software engineering techniques concepts used way providing support ubiquitous computing communication addition intelligent user interfaces require systems provide efficient rich interface user traditional ones paper presents platform called mapas uses ambient intelligence concepts techniques give fully scalable solution particular problem chosen system provides solution using platform personalize dissemination events system makes available user set events interest kind systems requires high degree user personalization however nowadays user must search events interest subscribe several different services pages platform introduced paper takes profit agent oriented technology provide system composed various agents may run different devices communicate provide user personalized selection events moreover system aware surrounding environment installed smart devices provides rich intuitive user interface uses augmented reality techniques give spatial location data events regarding characteristics solution seems suitable problems domain ambient intelligence
ambient intelligence suitable paradigm developing daily life solutions including health care domain many ageing adults decide live alone home need constant monitoring control health status quality life paper introduces description wearable device capable acquiring electrodermal activity eda order obtain information arousal level elderly lightweight wearable device placed wrist ageing adult allow continuous monitoring eda signals aim triggering changes emotional state ageing adult fifty pictures international affective picture system used assess electronic device series experiments initial results show overall system classifies people two classes calmed stressed patients results show measuring eda events magnitudes ageing adults arousal level classified global accuracy higher
ambient intelligence one research area wireless sensor devices commonly used main idea applications monitor recognize people indoor outdoor activities study focus one major problem wsn energy consumption different way existing approaches literature proposed approach shown possible create dynamic sleep scheduling mechanism recognized activity contrast previous studies found literature review perspective holistic approach takes component application level account proposed therefore energy consumption ways improving lifetime node network handled main aim find suitable region application work tolerable performance degradation meanwhile lifetime sensor extended decreasing energy consumption proposed approach tested accelerometer signal walking activity shown exists region application performance energy gain suitable
ambient intelligence next wave computing communication technology nano sensors wireless networks unified intelligent software main elements issue inputs ambient intelligence taken sensors environment wireless sensor networks consists small low cost sensors collect report environmental data wireless sensors dispersed area phenomenon event monitored sensor detects monitored event heat pressure sound light areas magnetic properties vibration etc event reported one sites site performs appropriate task sending message local processing based type network provides appropriate response one major challenges wireless sensor networks optimizing energy consumption studies shown clustering network nodes possible use energy efficiently study proposes clustering based routing method used wireless sensor networks multi objective optimization algorithm named non dominated sorting genetic algorithm used clustering seven objective functions described aimed carry several goals using multi objective algorithm communication cost objective functions cluster head sink cluster head non cluster head tried minimized selection cluster heads nodes near sink also tried prevented also taken consideration clusters include nodes much possible solution solution set obtained non dominated sorting genetic algorithm points different network topology solution solution set best solution according objective functions provided sink simulate solution solution set according certain scenario choose one suitable desired criteria proposed method operating non dominated sorting genetic algorithm simulation evaluation obtained solutions comes sink sufficient operation power sources according results proposed method make life span network five times longer leach famous clustering algorithm besides proposed method extends life span network also seen increases number packet reaching sink two times leach data provided proposed method includes information larger areas compared leach elsevier ltd rights reserved
ambient intelligence techniques smart internet things objects empowering healthcare professionals provide better services based improved vitalsigns data enriched contextual information paper provide overview current solutions propose new taxonomy ambient health sensor data based three selected metrics proposed unchain architecture provides ubiquitous communication system designed grant seamless integration current sensor solutions maximize two identified limitations range autonomy finally proposed architecture validated hardware implementation impressive results terms energy efficiency
ambient assisted living aal currently one important research development areas accessibility usability learning play major role future interfaces important concern applied engineering general goal aal solutions apply ambient intelligence technology enable people specific demands handicapped elderly live preferred environment longer term internet things iot used umbrella keyword covering various aspects related extension internet web physical realm means widespread deployment spatially distributed devices embedded identification sensing actuation capabilities context propose new methodology based self organizing maps soms fuzzy means fcm algorithms profile generation regards activities user correlation available sensors moreover utilize provided context assign generated profiles contextually complex activities methodology evaluated aal structure equipped several sensors precisely assess proposed method data set generated accelerometers performance number everyday activities
amendments made child abuse prevention treatment act individuals disabilities education improvement act opened door promising partnership child welfare services early intervention agencies requiring referral services children age involved substantiated case child abuse neglect illegal drug exposure however little research conducted assess implications policies using data drawn nationally representative study conducted observed less fifth children substantiated cases receive referral developmental services approximately years passage amendments children contact child welfare system hispanic children immigrants demonstrated greatest developmental need yet among least likely receive services end study period implications policy practice discussed
american girl multi product brand marketed transnationally discourses gendered empowerment education previous scholarship commented american girl encourages normative gender roles consumerism limited notions diversity scholars knowledge discussed disability relation brand article explores representation disability american girl contemporary line analysis books doll accessories unlike issues gender race class appear central american girl depiction contemporary girlhood disability literal metaphoric accessory brand contend representation disability supplementary prime example ablenationalism explicitly targeted girls
ami clearly next step evolution integration daily life computer technologies products despite revolutionary nature ami analysis media attention big middle century decade decreasing since mistake new social tendencies well advancements technological equipment data procession techniques allowing next step advancement ami general mistakes pointed labeled ambient stupidity broad philosophical analysis framework suggested order prepare improve advent big ami time critical remarks nature human cognitive processes introduced reviewed finally request new tools deal multivariate dynamic sources data showed necessity future researches
ammonia one produced chemicals worldwide currently synthesized using nitrogen separated air hydrogen natural gas reforming consequent high consumption fossil fuel high emission renewable path ammonia production desirable considering potential development ammonia energy carrier study reports design analysis innovative system production green ammonia using electricity renewable energy sources concept couples solid oxide electrolysis soe production hydrogen improved haber bosch reactor hbr ammonia synthesis air separator also introduced supply pure nitrogen soe operates extremely high efficiency recovering high temperature heat haber bosch reactor aspen used develop model study performance plant soe hbr operate degrees ammonia production zero emission obtained reduction power input compared equivalent plants elsevier ltd rights reserved
among alternative fuels compressed natural gas cng considered one best solutions fossil fuel substitution availability throughout world inherent clean burning economical fuel adaptability gasoline diesel engines bibliography reviews potential cng transportation fuel added bibliography end article contains references papers conference proceedings theses dissertations subject published references retrieved scientific journals references classified following categories regional experience cng vehicles economic aspect cng vehicles cng engine design control performance combustion fuel injection characteristics cng engines cng diesel dual fuel operations hydrogen enriched cng vehicles environmental aspect cng vehicles safety aspect cng vehicles elsevier ltd rights reserved
among anxious populations attention demonstrated preferentially biased threatening material compared neutral valenced material individuals high levels trait worry generalized anxiety disorder gad may biased threat research produced equivocal findings review aimed systematically review extant experimental literature establish current evidence attentional bias threat among trait worriers compared healthy controls clinical populations twenty nine published articles included final review strong evidence bias threat among gad patients compared groups found across experimental paradigms studies investigated bias non clinical trait worriers among gad patients bias threat strongly evidenced visual threat material verbal linguistic format words rather pictorial form images faces bias also found across several domains negative material supporting general nature worry research look examine specific components threat bias gad well investigating bias threat trait worriers
among protein residues cysteines one prominent candidates ros mediated rns mediated post translational modifications hydrogen peroxide main ros candidate inducing cysteine oxidation reaction common cysteine residues reactivity utmost prerequisite sensitivity towards indeed deprotonated cys thiolate form react leading sulphenic acid formation soh considered major central player ros sensing pathways however cysteine sulphenic acids generally unstable oxidized irreversible forms sulphinic sulphonic acids soh soh respectively alternatively proceed towards modifications including disulphide bond formation glutathionylation ssg sulphenamide formation understand cysteine residues undergo primary oxidation sulphenic acid explore stability cysteine sulphenic acids combination biochemical structural computational studies required discuss current knowledge structural determinants cysteine reactivity sulphenic acid stability within protein microenvironments review highlights importance acidity nucleophilicity protein cysteine thiols determining rate mediated primary oxidation sulphenic acids stability reactivity sulphenic acids also investigated strictly correlated cysteine microenvironment dependent upon structural determinants specific protein sensitive oxidation findings reinforce prominent role cysteine sulphenic acids redox signalling combination biochemical structural computational approaches mandatory get insight kinetic thermodynamics factors controlling cysteine oxidation
among gastrointestinal hormones regulate food intake energy homeostasis ghrelin plays unique role first one identified increases appetite stimulate secretion review highlights latest mechanism ghrelin modulates body growth appetite energy metabolism exploring pharmacological actions hormone consequences genetic pharmacological blockade ghrelin ghs growth hormone secretagogue receptor system physiological responses specific nutritional situations within hypothalamus novel mechanisms action hormone involve interaction ghrelin derived peptides desacyl ghrelin obestatin thought act functional ghrelin antagonists possible modulation ghs protein coupled receptors chronic undernutrition anorexia nervosa variations ghrelin derived peptides may adaptative metabolic response maintain normal glycemic control interestingly ghrelin metabolic actions thought relayed modulation anabolic hyperglycemic agent elsevier ireland ltd rights reserved
among many diagnostic therapeutic uses ionizing radiation medicine potential misuse greatest diagnostic imaging particularly computed tomography several technical adjustments may made produce dose low reasonably achievable appropriate utilization tests difficult issue address risks ionizing radiation taking account patient age sex body part examined must balanced potential benefit comes medical imaging fortunately benefits outweigh risks clinical scenarios particularly patients without confirmed diagnosis however repetitive imaging patients known clinical conditions assess interval change may pose greatest opportunity curb utilization imaging tests may harmful medical community large must educated effects ionizing radiation moreover practitioners must inspired differentiate imaging tests primary diagnosis performed follow known pathology common diagnostic algorithms metamorphosis must extend senior health care administrator junior healthcare professional must include charged acquiring necessary imaging tests addition imaging professionals must avail numerous technical advances allow reduction dose ionizing radiation associated common imaging procedures dose monitoring must performed many levels including dose individual patient undergoing specific imaging test
amounts landslide deposits triggered wenchuan earthquake magnitude may landslide deposits composed soil rock fragments play important roles hydrological erosion processes steep slope landslide deposits mixtures soil gravels common top layers landslide deposits processes obviously different soil without gravels based data field investigation series simulated scouring flow experiments four proportion gravel three scouring flow rates min two steep slopes conducted sequentially know effects proportion gravel infiltration capacity runoff generation sediment production steep slope landslide deposit results indicated gravel promoted reduced effects infiltration capacity could affect cumulative runoff volume cumulative sediment mass increase decrease cumulative infiltration volume proportion gravel less proportion gravel cumulative runoff volume order cumulative sediment mass ranked different proportions gravel significant power relationship found scouring time cumulative runoff volume well cumulative sediment mass relationship average soil water loss rate proportion gravel able express quadratic function high degree reliability results important implications soil water conservation modeling landslide deposit also provide useful information similar conditions
amphetamine drugs abuse short term long lasting effects brain function drug sensitization paradigms often result chronic impairments behavioral flexibility show acute amphetamine administration temporarily renders rats less sensitive reward omission revealed decrease lose shift responding binary choice task intracerebral infusions amphetamine ventral striatum affect lose shift responding increase impulsive behavior rats chose check reward feeders beginning next trial contrast acute systemic intracerebral infusions sensitization repeated exposure induced long lasting increased sensitivity reward omission treatments affect choices trials following reward delivery win stay responding sensitization increased spine density sensorimotor striatum dichotomous effects amphetamine short term long term loss sensitivity null effect win stay responding consistent shift behavioral control sensorimotor striatum drug sensitization data provide new demonstration shift novel task unrelated drug administration suggests dominance sensorimotor control persists many hundreds trials sensitization article part special issue entitled cognitive flexibility ibro published elsevier ltd rights reserved
amphotericin amb poorly soluble toxic antifungal drug encapsulated polymeric micelles self assembled phenylboronic acid functionalized polycarbonate peg peg pbc urea functionalized polycarbonate peg peg puc diblock copolymers via hydrogen bonding boronate ester bond ionic interactions boronic acid group micellar core amine group amb three micellar formulations prepared amb micelles using peg pbc amb micelles using peg puc amb mixed micelles using molar ratio peg pbc peg puc average particle sizes micelles range narrow size distribution zeta potentials close neutral vis absorption analysis indicated amb micelles significantly reduced amb aggregation status due interactions amb micellar core fungizone amb micelles effect amb mixed micelles exerted intermediate effect amb micelles amb mixed micelles showed sustained drug release amb released respectively sink conditions amb micelles displayed burst release profile amb loaded micelles showed comparable antifungal activity free amb fungizone amb micelles amb mixed micelles much less hemolytic formulations histological examination showed amb amb micelles led significantly lower number apoptotic cells kidneys compared fungizone suggesting reduced nephrotoxicity micellar formulations vivo phenylboronic acid functionalized polymeric micelle systems promising drug carriers amb reduce non specific toxicities without compromise antifungal activity statement significance pressing need novel cost effective delivery system reduce toxicity induced antifungal agent amphotericin amb study phenylboronic acid functionalized polycarbonate peg diblock copolymers used fabricate micelles improved amb micelle interaction via manipulation hydrogen bonding boronate ester bond ionic hydrophobic interactions compared free amb fungizone resultant micellar systems displayed improved stability reducing non specific toxicities without compromise antifungal activity findings demonstrate potential biodegradable functional polycarbonate micellar systems promising carriers amb treatment systemic fungal infections acta materialia inc published elsevier ltd
ample vitro vivo experimental evidence supports hypothesis intercellular transmission alpha synuclein alpha mechanism underlying spread alpha pathology parkinson disease related disorders remains unexplained initial transmissible alpha aggregates form previous study demonstrated alpha aggregates rapidly form neurons impaired nuclear membrane integrity due interaction nuclear proaggregant factor alpha aggregates may serve source alpha seeding present study identify histones potential nuclear proaggregant factor alpha aggregation apoptotic neurons brains alpha pathology demonstrate histone induced aggregates contain range alpha oligomers including protofibrils mature fibrils alpha aggregates seed additional aggregation importantly demonstrate transmissibility mouse brains stereotaxic injection study provides new clues mechanism underlying initial pathological aggregation alpha related disorders could lead novel diagnostic therapeutic approaches
ampoule injection routinely used treatment hospitals due rapid effect intravenous injection manufacturing tiny foreign particles present ampoule injection therefore strict inspection must performed ampoule injections sold hospital use quality control inspection process ampoule enterprises still rely manual inspection suffers inherent inconsistency unreliability paper reports automated system inspecting foreign particles within ampoule injections custom designed hardware platform applied ampoule transportation particle agitation image capturing analysis constructed trajectories moving objects within liquid proposed use differentiate foreign particles air bubbles random noise accurately classify foreign particles multiple features including particle area mean gray value geometric invariant moments wavelet packet energy spectrum used supervised learning generate feature vectors results show proposed algorithm effective classifying foreign particles reducing false positive rates automated inspection system inspects ampoule injections per minute versus technologist higher accuracy repeatability addition automated system capable diagnosing impurity types existing inspection systems able classify detected particles note practitioners present quality assessment ampoule injections pharmaceutical manufacturing relies manual operation certified technologists machine assisted detection systems existing technologies able effectively distinguish symbols dirt surface ampoule air bubbles random noise foreign particles inside ampoule paper reports automated ampoule inspection system consisting two working stations high speed revolving station abruptly stopping station system agitates particles rotates spirally along axis ampoule container based image processing trajectories construction foreign particles effectively detected distinguished air bubbles random noise
year old woman history essential thrombocythemia presented ocular pain bleeding decreased visual acuity left eye orbital computed tomography revealed relatively well defined homogenous mass like lesion left subconjunctival intraconal space conjunctival biopsy showed acute inflammation necrosis vascular ectasia thrombosis hemorrhage treatment hydroxyurea anagrelide symptom lesion markedly improved hematologic disorders like essential thrombocythemia considered patients severe spontaneous bleeding around eye
accurate charge based compact mosfet model developed using third order hermite interpolation polynomial approximate relation surface potential inversion charge channel new formulation drain current retains simplicity advanced charge based compact mosfet models bsim acm ekv developed without requiring crude linearization inversion charge hence asymmetry non linearity channel accurately accounted nevertheless expression drain current worked analytically equivalent bsim acm ekv furthermore thanks new mathematical approach slope factor rigorously defined regions operation empirical assumption required elsevier ltd rights reserved
air exposed single chamber microbial fuel cell scmfc using microalgal biocathodes designed reactors tested simultaneous biodegradation real dye textile wastewater rtw generation bioelectricity results digital image processing revealed maximum coverage area biocathodes microalgal cells atmospheric diffused could enable good algal growth immobilized operation cathode electrode biocathode scmfcs outperformed open circuit voltage ocv higher control furthermore maximum volumetric power density achieved system suitable treatment rtw removal decrease cod colour heavy metals high removal efficiencies observed scmfcs cod removal efficiencies considerably lower observed single chamber mfc simplifies double chamber system bio electrochemical performance relatively low treatment capacity system seems encouraging contrast previous studies proof concept experiment demonstrated microalgal biocathode could operate air exposed conditions seems promising alternative cathode efficient cost effective approach improve performance single chamber mfcs elsevier ltd rights reserved
algorithm code spectrum calculation periodic nanostructures homogeneous magnetic field developed approach based zero range potentials model mathematical background model based theory self adjoint extensions symmetric operators
algorithm wave method structural health monitoring shm tested calibrated using shake table experiment data full scale seven story reinforced concrete building slice method based monitoring changes velocity waves propagating vertically structure identified least squares lsq fit beam models experiment conducted team university california san diego ucsd network earthquake engineering simulations nees outdoor shake table ambient noise white noise earthquake response data four progressive damage states analyzed algorithm tested first time highly dispersive wave propagation damaged structure much shorter segments ambient vibration data used previously structure modeled timoshenko beam large shear stiffness compressional wave velocity identified change measured different damage states compared change fundamental frequency vibration effectiveness method discussed american society civil engineers
tic nanocomposite powder different percentages tic nanoparticles synthesized via high energy ball milling increasing tic nanoparticles content crystallite size began decrease led increase hardness produced nanocomposite tic laminated nanocomposite fabricated effect process parameters charpy impact energy cie crack divider crack arrester configurations investigated comparison experimental results shows crack divider crack arrester configurations cie laminated nanocomposite much higher monolithic one also reported accurate estimate process parameters order maximize charpy impact energy tic laminated nanocomposite accordingly datasets collected experiments modeling algorithm called gene expression programing gep mathematical relation cie process parameters developed afterwards optimization algorithm called biogeography based optimization bbo process parameters optimized order achieve maximum cie experiments performed optimized parameters prove validity analysis shows potential application calculations analysis materials engineering elsevier ltd techna group rights reserved
amplifier capacitor sharing technique applications multiplying digital analog converter mdac cmos pipelined acdc presented amplifier used implementation recycling amplifier based folded cascode operational amplifier gain improved using positive feedback operational amplifier designed cmos process show simulated gain frequency bandwidth mhz phase margin degree power consumption power supply simulation results mdac bits show configuration used implementation bits msample cmos pipelined adc power consumption analog part supply
analytic model presented quantitatively investigating impact friction punch shot sleeve dynamic match status injection process squeeze casting ultimate purpose optimizing machine design controlling injection process accurately combining lubrication model friction experiment friction characteristics punch shot sleeve investigated four cases different clearance values lubrication model validated comparing calculated experimental values friction coefficient friction model injection process established means updating incremental boundary conditions iteratively temperature deformation data collected laboratory testing used compare simulation data obtained general model proposed friction model simulation data friction model approximately agreement experimental data better general model implying proposed analytics model provides accurate simulation friction coefficients elsevier rights reserved
analytic thermodynamic model established quantitatively investigate wetting states droplets nanopatterned surfaces based calculations free energies droplets wenzel state cassie baxter state found size shape nanostructured surfaces play crucial roles wetting states detail nanohole patterned surfaces deep thin nanoholes lead cassie baxter state contrarily shallow thick nanoholes result wenzel state however droplets wenzel state patterned surfaces small height radii nanopillars cassie baxter state height radii nanopillars large furthermore intuitive phase diagrams wetting states droplet space surface geometrical parameters obtained theoretical results good agreement experimental observations reveal physical mechanisms involved effects nanopatterned surfaces wetting states implies studies may provide useful guidance conscious design patterned surfaces control wetting states droplets
association circadian clock function mood regulation well established proposed factor development mood disorders patients depression mania suffer disturbed sleep wake cycles altered rhythms daily activities environmentally disrupted circadian rhythms increase risk mood disorders general population however proof disturbance circadian rhythms causally involved development psychiatric disorders remains elusive using clock gene mutants manipulations sleep wake light dark cycles brain lesions affecting clock function animal models developed investigate whether circadian rhythm disruptions alter mood review selected animal models examined address issue causality circadian rhythms affective behavior
effective theory based intervention strategy developed improve worker adoption ventilated dust control tool reduces dust exposure prevention design adoption readiness model ptd arm employed develop educational materials hands training worksite cues action educational materials targeted improve worker knowledge health risks associated construction dusts hands training developed objective improving worker self efficacy regarding new equipment additionally cues action given workers cues hard hat stickers shirts reminder slogans pretest posttest experimental design control group questionnaire data analyzed using independent tests gain scores significant changes seen worker self efficacy trust technology overall readiness adopt tool theory based intervention strategies found effective improving worker willingness use ventilated tools impactful intervention methods include training regarding risks worker health hands training ventilated tools cues action reminders use tools
efficient exploitation distributed computing infrastructures dcis needed deal data deluge scientific community facing particular astrophysics one due emerging square kilometre array ska telescope reach data rates exascale domain hence science gateways enriched advanced tools enable scientists build experiments also optimize adaptation different infrastructures work present method called two level workflow system build kind tools apply set analysis tasks interest use applications ska method uses software service model keep scientists insulated technical complexity dcis compss programming model achieve efficient use computing resources
electrical breakdown onboard equipment orbital space vehicles consequence multifactor physical process related vacuum electronics low temperature plasma physics gas discharge problem becomes especially urgent connection application onboard electrical network voltage higher exceeds arcing threshold given problem actively investigated years result number standards regulating measures prevention secondary arcing consequence electrostatic breakdown currently force world however arcing caused internal processes onboard equipment without high voltage initiation yet practically studied despite existence problem makes investigations urgent present work contains results experiments registration threshold parameters first pressure determines risk secondary arcing presence plasma imitating primary discharge plasma caused wire evaporation results experiments confirm expected decrease threshold breakdown voltage minima paschen curve experimental approaches used work methodological interest imitation arcing conditions testing stability equipment arcing orbital space
electrical generator integrated locally produced biomass fed clay cooking stove rural malawi generator produces small amounts electricity based thermoelectric effect five demonstrator stoves deployed rural community balaka district months study investigates power generation performance devices first days field trial determined users able charge mobile phones lights radios generator stoves power generating performance stoves deteriorated slightly day period due effects thermal cycling generator system whole caused eventual drying thermal paste loosening clamping nuts reduces clamping pressure power output one stove failed due mechanical problem found power produced significantly exceeded power consumed cases indicates supply appears sufficient meet average daily electrical power requirements participants study data obtained field trial used inform redesign device second field trial elsevier ltd rights reserved
enhanced asymmetric cryptosystem color image proposed using equal modulus decomposition emd gyrator transform domains scheme emd performed create effective trapdoor one way function moreover enhance security cryptosystem baker mapping considered utilized scrambling rgb components color image parameters baker mapping gyrator transform served extra keys entire cryptosystem various types attacks considered robustness analysis experiments numerical simulations made verify validity capability proposed color encryption algorithm
estimated stroke patients underlying dementia consequence health professionals often face challenge managing patients dementia presenting acute stroke patients dementia less likely receive thrombolysis thrombolysis rates general population admitted stroke unit receive types care anticoagulation secondary stroke prevention sometimes withheld despite dementia listed exclusion criterion current guidelines studies population scarce results contradictory three observational studies examined intravenous thrombolysis treatment acute ischaemic stroke patients dementia two largest matched case control studies significant differences patients without dementia risks intracerebral haemorrhage mortality risk intracerebral haemorrhage ranged patients dementia studies interventions stroke lacking population patients dementia less likely discharged home compared controls likely disabled die hospitalization aim review summarize current knowledge management ischaemic stroke patients pre existing dementia including organizational aspects stroke care intravenous thrombolysis access stroke unit care use supportive treatment evidence support anticoagulation secondary prevention stroke patients atrial fibrillation antiplatelet therapy nonembolic stroke discussed well rehabilitation factors influence patient outcomes finally ethical issues knowledge gaps pathways future research considered
exact closed form synthesis method proposed design narrowband reflection type mono port phasers arbitrary prescribed group delay responses proposed synthesis technique consists three steps first transforms phase problem bandpass domain low pass domain using one port ladder network mathematical synthesis performed via hurwitz polynomial second transforms synthesized low pass network back bandpass domain implementation specific technology third uses iterative post distortion correction technique compensate distributed effects broader bandwidth required proposed synthesis method verified full wave analysis experiment synthesized bandpass network realized iris coupled waveguide configuration
exit survey powerful tools allow university obtain information students satisfaction range academic supervision experiences study ukm inquire plans future study used set questioimaires comprise five main sections section general background section achievement section educational achievement throughout years ukm section career preparation section relationship lecturer student study conducted two consecutive sessions semester based findings achievement sessions shows satisfactory result students achieved scales except session next curriculum teaching learning process four years study showed students achieved scales trend also occurs career aspect lowest year later finally relationship student staff revealed lowest score mentor mentee system authors published elsevier ltd
experimental program large scale direct shear tests indicated shear displacement gravel drainage layer nonwoven geotextile protection layer high density polyethylene hdpe geomembrane moderate high normal stress conditions cause much greater damage geomembrane static pressure alone essentially damage observed low normal stress greatest damage occurred high normal stress kpa using lightweight geotextile yielded average holes maximum hole size surprisingly geomembrane damage measured using lightweight geotextile greater measured using geotextile due change failure surface location conditions shear induced damage slightly less geomembrane placed compacted sand subgrade compacted clay subgrade interface shear strength increased significantly decreasing geotextile mass area due greater plane deformation geomembrane findings suggest placement gravel drainage layer top hdpe geomembrane even protection nonwoven geotextile viewed caution landfill bottom liner systems moderate high stress applications reasonable expectation interface shear displacement project specific direct shear tests conducted determine potential shear induced geomembrane damage recommendations provided performance tests design options damage mitigation necessary american society civil engineers
experimental study performance optimisation prototype novel drag driven vertical axis tidal stream turbine presented drag turbine several unique advantages including simple blade design deployable shallow waters potential denser array spacing performance optimisation conducted hydraulics flume cardiff university turbine reached max lambda degrees phase angle configuration turbine tested using wider deeper hydraulics flume ifremer france testing ifremer reduced blockage factor range unblocked conditions testing unblocked environment similar flow conditions reduced peak efficiency turbine max lambda finally turbine compared performance savonius turbine design savonius based literature review turbine showed inferior efficiency values compared performance savonius savonius reached max lambda unblocked conditions greater max drag turbine authors published elsevier ltd open access article license http creativecommons org licenses
extensive literature exists regarding potential effect sleep loss human performance recent regulatory changes limit duty hours resident physicians recent studies reviews emphasize effects sleepiness medical errors commission lesser extent omission review focuses emerging literature effects sleep loss personal social professional growth development residents early literature sleep loss resident performance literature largely observational level sufficient evidence professions indicate sleep loss affect post graduate career life skills multidimensional approach needed counter adverse outcomes sleep loss fatigue might consist education healthy sleep habits family outreach personal alertness strategies reversal bias sleepiness personally disclosed multi dimensional approach might include resident physicians also residency program directors attending physicians institutions elsevier ltd rights reserved
extract indigenous plant jack bean canavalia ensiformis used produce calcite effective biomaterial formation calcite using extract compared stable conditions using commercially available purified urease xray diffraction scanning electron microscopy employed elucidate mechanism calcite formation crude plant extracts results revealed urease jack bean crude extracts catalyzed hydrolysis urea liquid state cultures procedure described herein simple useful method calcite mineral precipitation require cultivation microorganisms purification crude extracts study suggests crude extracts canavalia ensiformis potential used place purified forms urease remediation cracks increase strength materials
important challenge memory competition appropriate inappropriate information retrieval competition normally reduced thanks controlled inhibitory processes suppress irrelevant memories alzheimer disease compromise suppression ability may result strong competition relevant irrelevant memories retrieval present review highlights issue examining studies using directed forgetting method method participants typically instructed forget longer relevant information argued reflect suppression memory studies using directed forgetting method suggest participants experience difficulties asked suppress longer relevant information working autobiographical source destination memory difficulties suppressing irrelevant information may observed may hamper memory retrieval activating irrelevant memories expense relevant ones
important problem field bioinformatics identify interactive effects among profiled variables outcome prediction paper logistic regression model pairwise interactions among set binary covariates considered modeling structure interactions graph goal recover interaction graph independently identically distributed samples covariates outcome viewed feature selection problem simple quantity called influence proposed measure marginal effects interaction terms outcome case underlying interaction graph known acyclic shown simple algorithm based maximum weight spanning tree respect plug estimates influences strong theoretical performance guarantees also outperform generic feature selection algorithms recovering interaction graph samples covariates outcome results also extended model includes individual effects pairwise interactions via help auxiliary covariate
improved expansion method variable separation method studied present paper employing improved expansion method new soliton solutions dimensional bkp equations derived interesting physics structure help symbolic computation studied
indirect hysteresis voltage digital control proposed single phase half bridge inverters slow response switching modulation difficult control voltage hysteresis method directly study output voltage controlled indirectly using adaptive band hysteresis current control fast response robustness independent system parameters reference current computed based desired reference output voltage hysteresis band controlled maintain switching frequency constant value simulation results show good performances proposed control method cases reference output voltage
indirect type forced convection solar dryer using phase change material pcm designed constructed experimentally investigated dryer consists solar air panel direct heating drying agent solar energy accumulator solar air collector pcm cavity drying chamber solar dryer tested load without pcm present study aimed investigating feasibility using solar air heater pcm store solar energy daytime release night experiments conducted evaluate charging discharging characteristics latent storage unit pcm cavity daily energy efficiency solar energy accumulator reached daily exergy efficiency reached results show using solar energy accumulator temperature drying chamber higher ambient temperature degrees night addition relative humidity drying chamber observed lower ambient relative humidity case solar dyer pcm elsevier ltd rights reserved
initially wet contact filter paper test cfpt initially dry contact filter paper test cfpt used examine wetting paths geosynthetic clay liners including non contact filter paper tests comparative purposes cfpts applied geosynthetic clay liner faces examine effect geotextile type capillary contact non woven geotextile face found likely cause capillary breaks woven geotextile face cfpts found applicable geosynthetic clay liners within accurate upper matric suction measurement limits kpa kpa respectively
interconnected electrical network electrical sources loads makes small scale power system ssps systems low inertia makes modeling controlling dissimilar traditional large scale power systems differential game theoretic framework allows design distributed control structures ssps player dynamics simultaneous player movement approach loads sources defined players system form game energy gametheory based modeling necessary case since optimizes multiobjective optimization problem based local control without need communication channel paper differential game theoretic approach used path optimization load players cold start minimizes losses achieves desired steady state operating point example simulation cases obtained power system nine buses dynamic load players power system used show applicability effectiveness performances proposed concepts however method easily applied types larger networks finally experimental results yielded validate theoretical results show proposed controller higher performance compared traditional proportional integral controller transients
intriguing area research thyroidology recently discovered association insulin resistance thyroid functional morphological abnormalities individuals hyperinsulinemia larger thyroid gland higher prevalence thyroid nodules cancer accordingly patients treated metformin smaller thyroid volume lower risk incident goiter thyroid nodule cancer multiple studies vitro vivo demonstrated metformin inhibit growth thyroid cells different types thyroid cancer cells affecting insulin igf mtor pathways besides metformin treatment associated decrease levels serum thyroid stimulating hormone tsh diabetic patients possibly enhancing effects thyroid hormones pituitary activating adenosine monophosphate activated protein kinase ampk based evidence metformin appears promising therapeutic tool patients thyroid disease clinical studies necessary evaluate clinical significance metformin treatment thyroid diseases
sequence sequence preestimator scheme direct sequence spread spectrum signal acquisition using block sequence estimation bse proposed analyzed proposed scheme consists estimator verifier work according sequence chip clock provides enhanced chip estimates threshold decision logic one chip error correction among first received chips also reliability check estimates additional decision logic probabilities estimator verifier operations calculated results detection false alarm missing probabilities proposed scheme derived addition using signal flow graph average acquisition time calculated proposed scheme used preestimator easily implemented changing internal signal path generally used digital matched filter dmf correlator correlator lot sampling data memories sampled sequence numerical results show rapid acquisition performance relatively good cnr
ongoing discussion partner violence literature exists concerning respective roles perpetrator victim gender based classical feminist argument women victims violence sustained social perception victims recently increased recognition mutual violence taken place calling question gender based victim perpetrator model recent research calls question role differentiation findings indicating majority protagonists drama view victims corollary controversy whether man woman victim principal client conventional intervention woman paper argue relevancy gender based role differentiation cases supported recent data incorporating interactive perspective enables complex view classical victim perpetrator one may improve practice populations
optimal controller high precision spiral positioning piezoelectric tube scanner used atomic force microscope afm proposed paper proposed control scheme second order vibration compensator incorporated piezoelectric tube scanner pts suppress vibration pts resonant frequency internal model reference sinusoidal signal included augmented plant model integrator introduced linear quadratic gaussian controller reduces phase error input output sinusoids proposed method allows commercial afm scan high scanning speeds alternative raster scanning approach performance controller assessed closed loop frequency response tracking accuracy set spiral scanned images raster scanned images obtained using standard afm controller also presented comparison spiral images experimental results prove effectiveness proposed method note practitioner main motivation work propose control system high speed imaging using afm scanning speed commercial afm limited positioning accuracy scanner scanner made piezoelectric tube actuator commercially available scanners following problems creep effect slow speed scanning hysteresis effect large range scanning two effects result inaccurate reference motion tracking vibration effect high frequencies due mechanical flexibility overcome limitations internal reference model based linear quadratic gaussian control approach designed experimentally implemented using dspace real time prototype system control design scanner modelled experimentally using system identification method vibration compensator incorporated identified model apart control design spiral motion scanner considered instead well known raster scanning adopted commercial afms designed controller applied piezoelectric tube scanner experimentally obtained results presented terms tracking accuracy damping scanners vibration generating high quality images compared existing commercially available methods existing commercial system generate sensible image scanning frequency using proposed method high quality image achieved slight software modification proposed improvement used commercial afms
optimization design simulating electro mechanical property conductive elastic knitted fabric built based loops structure biaxial extensions computer program give fabric equivalent resistance obtained solving circuit network equations simplify computational process immensely order simplify calculation contacting forces overlapped yarns two hooked yarns used represent loop configurations theoretical analysis experimental investigations found resistance changing due yarn segment transfer key factor sensitivity elastic fabric sensors makes resistance linear increasing strain increasing analysis experimental results show change resistance fabric sensor due contact resistance minor contribution sensitivity sensor large strain regime also fabric structure yarn elongating affect characteristics fabric sensor
output feedback dynamic control scheme proposed efficient velocity trajectory tracking tasks direct current electric motors asymptotic differentiation approach signals also introduced applied real time angular acceleration estimation novel feature differentiator signals require system mathematical model hence presented differentiation approach admits wide variety practical applications diverse electric power systems require signal differentiation control identification synthesis differentiation scheme considers possible practical scenario contaminated output signals reasonably small noise computer simulations results included show controller robustness reject completely unknown chaotic load torque disturbances parametric uncertainty well effectiveness differentiation scheme signals elsevier rights reserved
overview wind tunnel activities methodologies developed last years support design long span suspension bridges proposed important aspects wind bridge interaction investigated considering aerodynamic phenomena affecting different parts bridge mainly deck towers experimental activities results proposed framework synergic approach numerical experimental methodologies represents common practice defining full scale aeroelastic behavior bridge starting scaled reproduction wind bridge interaction static dynamic wind loads aeroelastic stability vortex induced vibrations investigated elsevier ltd rights reserved
update published esur recommendations mri sonographically indeterminate adnexal mass integrating functional techniques provided algorithmic approach using sagittal set transaxial twi allows categorization adnexal masses one following three types according predominant signal characteristics bright masses due fat blood content simply effectively determined using combination fstw imaging concern solid component within mass requires additional assessment complex cystic cystic solid mass low solid adnexal masses dwi recommended masses low dwi signal high value image regarded benign solid adnexal mass displaying intermediate high dwi signal requires assessment contrast enhanced imaging ideally dce type curve highly predictive malignancy complex cystic cystic solid masses dwi cetw preferably dce mri recommended characteristic enhancement curves solid components discriminate lesions highly likely malignant highly likely benign aeuro cent mri useful complementary imaging technique assessing sonographically indeterminate masses aeuro cent categorization allows confident diagnosis majority adnexal masses aeuro cent type contrast enhancement curve strong indicator malignancy aeuro cent sonographically indeterminate masses complementary mri assists triaging patient management
upsurge popularity homestays provided newer economic opportunities remote indian himalayan communities despite benefits homestays offer acceptance mountain communities fraught challenges qualitative research study listened given voice homestay scheme non participants community members villages kuilu region thematic analysis rational understandable reasons leading decisions engage identified socio cultural practical apprehensions reasons include inability comply certain guidelines scheme inadequacy sanitary infrastructure gender roles complex socio cultural issues also home model issues condition scheme implementation concept deliberate non participation advanced extends previous typologies community participation theoretical practical implications study discussed along recommendations future development homestay scheme elsevier ltd rights reserved
analysis sunlight solar potential requires data targeted scene authentic accessible much possible regard data real world scene acquired ground based laser scanners comprehensive convenient thus potentially meeting requirement get accurate result offer automatic solution sunlight analysis paper proposes solar potential analysis method run directly ground laser scanning point clouds method simulates natural illumination sunlight hours solar radiation targeted scene specified period method first extracts region interest roi obtain targeted points compute solar position virtual light source propose control method acting roi constraint deviation point light source finally adopt generalized hidden point removal algorithm cast shadow obstruction roi besides experiments validate shading method results carried three different periods quantitative results xiamen case evaluated hausdorff distance demonstrate advantage feasibility proposed method
analytic two dark soliton solutions variable coefficient nonlinear schrodinger equation obtained via modified hirota method parallel solitons observed soliton control soliton compression realized different group velocity dispersion profiles besides soliton interactions investigated interaction distance adjusted addition soliton repulsive structures well attractive ones obtained exponential dispersion profile results research may useful soliton control inhomogeneous optical fibers benefit realistic optical communication systems elsevier ltd rights reserved
analytical solutions modeling geotextile tubes filling process approximation method determine densified tube shape reviewed geotextile tube filling analysis based plaut suherman two dimensional solution geotextile tubes weightless frictionless inextensible membrane resting rigid horizontal foundation subjected internal external hydrostatic pressures approximation densified tube shape developed leshchinsky adopted modified method approximating densified tube shape based areal strain deformation analysis introduced design diagrams useful approximating geotextile tube measurements design process provided
analytical solutions van der waals normal form fluidized granular media done study phase separation phenomenon using two different exact methods painleve analysis discussed illustrate integrability model equation auto backlund transformation presented via truncated expansion symbolic computation results show exact solutions model introduce solitary waves different types solutions hydrodynamic model van der waals equation exhibit behavior similar one observed molecular dynamic simulations two pairs shock rarefaction waves appear move away giving rise bubbles dispersion properties relation group phase velocities model equation studied using plane wave assumption diagrams drawn illustrate physical properties exact solutions indicate stability bifurcation elsevier rights reserved
anaplastic thyroid cancer medullary thyroid cancer primary thyroid lymphoma primary thyroid sarcoma rare thyroid cancers comprise thyroid malignancies unlike well differentiated thyroid cancers malignancies treatment options carry worse prognosis literature surrounding pathologies limited remains area active research despite rarity conditions remain important part differential diagnosis thyroid nodule awareness presentation work management critical oncologists head neck surgeons purpose article provide broad overview malignancies emphasis emerging clinical research therapies royal college radiologists published elsevier ltd rights reserved
androgen deprivation therapy adt mainstay treatment advanced prostate cancer treatment goal suppression plasma testosterone levels established decades evidence growing though suppression even lower levels may add clinical benefit therefore undertook pooled retrospective analysis efficacy month sustained release formulations gonadotropin releasing hormone gnrh agonist triptorelin suppress serum testosterone concentrations beyond current standards data male patients enrolled prospective studies using testosterone serum concentrations primary endpoint pooled patients aged years eligible adt either hormonal treatment undergone appropriate washout prior enrolment patients treated triptorelin formulations months primary endpoints analysis serum testosterone concentrations treatment success rates overall per formulation based testosterone target threshold months treatment patients reached testosterone levels respectively month formulations success rates ranged median interquartile range serum testosterone values study end respectively large majority patients triptorelin formulations suppressed serum testosterone concentrations even testosterone routinely monitored patients adt although studies clinical benefit low testosterone levels target concentrations still warranted
androgens play pivotal role cardiovascular function effects differ men women postmenopausal women testosterone replacement within physiological levels associated overall well however definitive explanation androgens impact cardiovascular health postmenopausal women whether may used cardiovascular treatment yet established aims systematic review existing studies link androgens cardiovascular disease effects testosterone therapy cardiovascular outcomes postmenopausal women conducted existing studies cardiovascular outcomes postmenopausal women indicate effect deleterious effect increasing androgens increased cardiovascular risk however evidence favorable effect androgens surrogate cardiovascular markers postmenopausal women high density lipoprotein cholesterol total cholesterol body fat mass triglycerides studies therefore needed clarify impact therapy androgens cardiovascular health postmenopausal women cardiovascular effect testosterone methyltestosterone without concomitant estrogens needs elucidated
andrographis paniculata paniculata chuanxinlian medicinal herb extremely bitter taste native china parts southeast asia possesses immense therapeutic value however therapeutic properties rarely applied field skin care study investigated effect paniculata extract ape human epidermal stem cells epscs confirmed anti aging effect vitro vivo vivo study mtt assay used determine cell proliferation flow cytometric analysis propidium iodide used evaluate cell cycle expression integrin stem cell marker detected antibodies using flow cytometry vitro immunohistochemical assays vivo type collagen vegf vascular endothelial growth factor measured using enzyme linked immunosorbent assay elisa clinical study skin hydration elasticity wrinkling sagging dermal density evaluated treatment four eight weeks treatment test product containing ape face proliferation epscs treated ape increased significantly cell cycle analysis ape increased stages dose dependent manner expression integrin related epidermal progenitor cell expansion regulated ape treated epscs skin explants addition production vegf epscs increased significantly response ape treatment consistent results vegf ape treated epscs conditioned medium enhanced type collagen production normal human fibroblasts nhfs clinical study ape improved skin hydration dermal density wrinkling sagging significantly findings revealed ape promotes proliferation epscs regulation integrin vegf expression vegf might affect collagen synthesis nhf paracrine factor clinical studies suggested treatment formulations containing ape confers anti aging benefits based results suggest ape may introduced possible anti aging agent
anesthesiologists face stressful working conditions culminate burnout syndrome despite various studies protective measures attempted prevent situation burnout continues problem within profession impacting negatively physicians lives performance review article mechanisms consequences burnout described addition individual strategies stress management burnout reduction potential impact health care quality wellbeing anesthesiologists organizational strategies appear important role burnout reduction need used conjunction individual programs latter essential reducing stress burnout anesthesiologists improving happiness wellbeing new measures emotion regulation strategies mindfulness self compassion resilience empathy promotion shown approaches substantial supporting evidence reducing burnout improving stress management evaluation implementation self regulatory competencies challenge research necessary identify programs best suit needs anesthesiologists measure effects patient care health care system quality
angioedema asymmetric non pitting oedema face lips tongue mucous membranes delay diagnosis treatment fatal treatment lisinopril angiotensin converting enzyme ace inhibitor reason angioedema report case developed oral facial edema four years using lisinopril hydrochlorothiazide laryngeal oedema main cause death angioedema treatment choice angioedema including fresh frozen plasma inhibitor concentrations brk antagonists bradykinin receptor antagonists used case years old female patient suffering hypertension considered patient suffering two days swelling face neck non allergic angioedema distinguished five major forms acquired aao hereditary hae renin angiotensin aldosterone system raas blocker dependent pseudoallergic angioedema pas idiopathic angioedema iao admitted clinic diagnosis hereditary angioedema patient skin edema life threatening laryngeal edema emergency department treatment started using intravenous methylprednisolone diphenydramine well inhaled subcutaneous epinephrine simultaneously despite initial treatment patient died due insufficient respiration cardiac arrest patient history kidney disease
angioedema episodic swelling deep dermis subcutis submucosal tissue due increase local vascular permeability swelling may involve skin respiratory gastrointestinal tracts commonly involved areas periorbital region lips report case fatal laryngeal obstruction due angioedema likely caused angiotensin converting enzyme inhibitor decedent year old man witnessed developing sudden facial swelling acute respiratory difficulties quickly followed unresponsiveness past medical history suggested second episode angioedema without urticaria postmortem examination revealed complete laryngeal obstruction absence infection neoplasm autoimmune disease postmortem computed tomography head neck showed complete obstruction upper airway based current understanding pathophysiology different types angioedema suggest workup angioedema without urticaria forensic setting offer readers resources use practice
angioedema distinct disease entity often becomes clinical challenge physicians may cause life threatening condition whereas prompt accurate laboratory diagnostics may available although bedside diagnosis needs established based clinical symptoms signs family history therapeutic response later laboratory tests available currently five nine different types angioedema diagnosed laboratory testing occur minority patient population hereditary angioedema inhibitor inh deficiency type diagnosed low inh function concentration whereas type inh function low concentration normal even elevated concentration normal forms acquired angioedema inh deficiency type characterized low inh function concentration however concentration also low autoantibodies inh detected complement profile acquired angioedema inh deficiency type similar type form autoantibodies inh present hereditary angioedema due mutation coagulation factor xii diagnosed exclusively mutation analysis fxii gene diagnostic metrics available idiopathic histaminergic acquired angioedema idiopathic non histaminergic acquired angioedema acquired angioedema related angiotensin converting enzyme inhibitor hereditary angioedema unknown origin angioedemas diagnosed medical family history clinical symptoms therapeutic response excluding forms previously described several potential biomarkers angioedema used date research future could utilized clinical practice improve differential diagnosis therapy well prognosis angioedema
angiomyofibroblastoma rare benign tumor usually involves vulvovaginal area women reproductive age early menopause report lipomatous angiomyofibroblastoma year old multigravid woman tumor measured size contained prominent mature adipose tissue comprised approximately tumor
animal assisted psychotherapy aap inherently incorporates standpoints interventions ways action promoting development reflective function mentalization thus special value parent child psychotherapy two central tools aap contribute process first ethical stance therapist sees animals full partners therapy situation respecting subjects needs desires thoughts second tool combines nonverbal communication animals together relating understanding decoding body language everyone setting nonverbal communication aap enables access implicit communication patterns occurring parent child article provides survey theoretical development research constituting basis development therapeutic approaches improvement parent children dynamics followed description dyadic therapy model mentalization based treatment originating psychoanalytic relational orientation clinical examples provided illustrate aap processes parent child psychotherapy consent received examples aggregated
ankle injuries common health problem data ankle injury rates time trends population large scarce aim investigate incidence time trends population based emergency department treated ankle injuries related sports activities activities related daily living data obtained one national survey accidents injuries one based emergency department data linear regression used determine linear trends ankle injuries per person years number ankle injuries related sports activities activities daily living increased per person years number sports related ankle injuries treated emergency departments decreased per person years per person years activities daily living according data incidence rates ankle injuries around times higher registered emergency departments high incidence rates ankle injuries highlight need proper ankle injury treatment prevention
ankylosing spondylitis autoimmune disease characterized chronic inflammatory arthritis tumor necrosis factor induced protein like tipe responsible maintaining immune homeostasis inhibiting secretion inflammatory cytokines condition inflammation however whether tipe participates development remains unknown study measured mrna expression tipe tipe peripheral blood mononuclear cells pbmcs patients healthy controls qrt pcr results showed tipe expression significantly increased patients compared controls significant difference tipe two groups moreover expression tipe mrna patients decreased treatment tnf alpha blocker addition found tnf plasma patients induced tipe expression thp cells vitro importantly tipe mrna expression levels negatively correlated tnf alpha hscrp bath ankylosing spondylitis disease activity index basdai respectively patients results indicated tipe contributes pathogenesis published elsevier inc behalf american society histocompatibility immunogenetics
annually hunters shoot millions birds lead ammunition many studies indicate diverse often high lead levels edible parts game considering number hunters determined levels may pose public health risk shotgun pellets main source lead contamination game animal tissues despite numerous studies indicating lead contamination game birds significant reasons diverse contamination tissues toxic metal reported analysis presented paper suggests explanation diverse levels contamination game animal tissues sought physical phenomena generated projectile damaged animal tissues projectile penetrating target generates multi phase medium destroyed tissues simultaneously changes shape front part movement projectile example turbulent flow interpretation interaction projectile damaged tissues indicate variable unpredictable parameters projectile shot medium created projectile make impossible determine degree interaction phenomenon temporary cavity created shot seems determine magnitude lead transfer tissues surrounding path wound fluid mechanics also explains relatively high lead levels game birds comparison levels determined big game animals view unpredictability projectile animal body interactions assumed game bird shot lead pellets contains lead levels dangerous human health therefore use lead pellets bird shooting banned
anomalous pitting sensitivity titanium ammonium bromide solutions detected saturation conditions pitting observed visually anodic polarization positive hysteresis loop recorded electrochemical impedance spectroscopy eis shows increase resistance time without inductive element equivalent electrical circuits anomalous behavior may related changes molecular structure bonds saturation dilute ammonium bromide solutions pitting attack observed visually anodic polarization cyclic polarization shown positive hysteresis loop eis shows inductive loop related active pits exist anodic surface
anorexia nervosa serious psychiatric disorder high morbidity mortality established pharmacological treatments neurobiology condition poorly understood previous studies using magnetic resonance spectroscopy mrs shown may associated reductions indices brain glutamate however conventional field strengths difficult separate glutamate precursor metabolite glutamine objective present study use high field mrs measure concentrations glutamate three separate brain voxels women studied female participants healthy female controls underwent mrs scanning voxels placed anterior cingulate cortex occipital cortex putamen neurometabolites calculated using unsuppressed water signal reference corrected individual cerebrospinal fluid concentration voxel found participants significantly lower concentrations glutamate three voxels mean reduction glutamine levels altered concentrations acetylaspartate creatine gaba glutathione also unchanged however inositol lower participants anterior cingulate occipital cortex women apparently widespread reductions brain glutamate work needed assess change pathophysiological relevance whether consequence many physical changes produced food restriction
anterior cruciate ligament acl commonly injured ligament great impact athletes causing long absence play linked increased risks osteoarthritis today literature suggests knee braces may completely reduce acl injury mechanism risks ankle braces hand shown promising results aspects thus purpose research study effectiveness knee ankle brace restraint reducing acl injury risks increasing knee flexion reducing knee valgus angles eighteen healthy asian male subjects performed drop vertical jump maneuver platform motion analysis capture carried measure knee flexion knee valgus angles results show effect knee ankle brace restraint insignificant increasing knee flexion reducing knee valgus angles initial contact peak vertical ground reaction force vgrf ankle brace showed trends increasing knee flexion angles initial contact effect insignificant similarly ankle brace show significant effects knee flexion angles peak vgrf knee valgus angles instances knee brace little effect knee flexion angles showed significant effects valgus angle increase conclusion knee ankle brace restraint found effect reducing acl injury risks jump landing ankle brace use adversely increase acl injury risks shown weak effects reducing risks knee brace used study found suitable reducing valgus angles authors published elsevier ltd selection peer review responsibility school aerospace mechanical manufacturing engineering rmit university
antigen presentation mhc cells important adaptive immune responses class transactivator ciita human cta mouse master regulator mhc gene expression coordinates transcription factors necessary transcription mhc molecules humans genetic variations ciita associated differential expression mhc susceptibility autoimmune diseases made use cta congenic mouse strain expressing mhc haplotype investigate effect natural genetic polymorphisms type promoter cta mhc expression function demonstrate allelic variant type promoter cta resulted increased expression mhc macrophages higher mean florescence intensity conventional dendritic cells higher mean florescence intensity spleen peripheral blood increase mhc expression resulted increase antigen presentation cells vitro increased cell activation differential mhc expression cta however alter disease development models rheumatoid arthritis collagen induced arthritis human glucose phosphate isomerase peptide induced arthritis multiple sclerosis mog protein induced mog peptide induced experimental autoimmune encephalomyelitis first study address role allelic variant type promoter cta mhc expression autoimmune diseases shows cta polymorphisms regulate mhc expression cell responses necessarily strong impact autoimmune diseases
antimicrobial peptides amps produced living organisms play important role innateimmunity readily available non specific invading pathogenic microorganisms snakin tomato short cationic peptide forms lethal pores biomembranes microbes plant cells produced prepeptide signal sequence targeting acidic region decrease toxicity producing organism gene expression analysis qrt pcr tomato plants demonstrated constitutively expressed mostly leaves flowers fungal infection wounding external application phytohormones methyl jasmonate meja operating dependent defense response systemic reaction elevated expression gene triggered parts tomato plants abiotic stress factors like extreme temperatures dehydration affect expression upon wounding expression loxd strongly enhanced tomato fruits furthermore provide evidence protein level bioactive also increased upon application methyl jasmonate tomato seedlings elsevier gmbh rights reserved
antioxidants important compounds prevention diseases like cancer diabetes cardiovascular neurodegenerative diseases premature aging however sensitive light heat oxygen study caffeic acid caf chlorogenic acid cga rosmarinic acid natural antioxidants encapsulated spray drying using sodium carboxymethyl cellulose cmc overcome limitations industrial applications product yield values around encapsulation efficiency values higher particles revealed smooth spherical shape mean diameter considering volume size distribution microparticles loaded caf cga fully released min respectively antioxidant activity compromised highlighting potential spray dried cmc microparticles carriers natural antioxidants elsevier rights reserved
antiretroviral pre exposure prophylaxis prep demonstrated decrease hiv acquisition multiple efficacy trials medication adherence critical suboptimal several studies fifty hiv uninfected risk men sex men msm randomized cognitive behavioral intervention condition time session matched comparison counseling intervention experimental intervention entailed four nurse delivered initial two booster sessions based life steps art treatment adherence intervention comparison condition provided information supportive counseling primary analyses compared adherence wisepill tenofovir plasma levels months fifty eight msm screened enroll participants median age years old white completed college wisepill adherence high groups statistically different plasma tenofovir levels significantly higher intervention group months using mean substitution analysis computing missing variables however completer analyses using completing study visits statistically significant differences randomization conditions medication adherence high across cognitive behavioral life steps time matched counseling intervention prep adherence evidence suggesting superiority life steps pilot rct evaluation fully powered efficacy trial warranted assess robustness intervention
antisocial personality disorder aspd characterized pattern socially irresponsible exploitative guiltless behaviour aspd associated occurring mental health addictive disorders medical comorbidity rates natural unnatural death suicide homicide accidents excessive aspd predictor poor treatment response aspd begins early life usually age years diagnosed conduct disorder childhood diagnosis converts aspd age antisocial behaviours persisted chronic lifelong people aspd disorder tends improve advancing age earlier onset associated poorer prognosis moderating factors include marriage employment early incarceration adjudication childhood degree socialization
anxiety depression frequently occur borderline personality disorder relatively little research examined presence borderline personality features main domains affective instability identity problems negative relationships self harm individuals remitted current anxiety depression participants current remitted anxiety depression healthy controls selected netherlands study depression anxiety assessments included personality assessment inventory borderline features scale several clinical characteristics anxiety depression borderline personality features common depression anxiety current comorbid anxiety depression associated borderline personality features anxiety depression status explained variance borderline personality features self harm identity problems variance four domains large part variance shared anxiety depression disorders also explained significant amount unique variance severity anxiety depression level daily dysfunctioning positively associated borderline personality features individuals longer duration anxiety depression showed affective instability identity problems findings suggest patients anxiety depression may benefit assessment personality pathology may implications psychological pharmacological treatment elsevier ireland ltd rights reserved
anxiety disorders one common debilitating mental illnesses worldwide growing evidence indicates age dependent rise incidence anxiety disorders adolescence adulthood suggestive underlying neurodevelopmental mechanisms kappa opioid receptors kors known contribute development expression anxiety however functional role kors basolateral amygdala bla brain structure critical mediating anxiety particularly across ontogeny unknown using whole cell patch clamp electrophysiology acute brain slices adolescent postnatal day adult male sprague dawley rats found kor agonist increased frequency gaba mediated spontaneous inhibitory postsynaptic currents sipscs adolescent bla without effect adult bla sipsc amplitude either age kor effect blocked kor antagonist bni alone alter gaba transmission either age effect kor agonist ttx sensitive additionally kor activation alter glutamatergic transmission bla either age contrast inhibited sipsc frequency central amygdala cea ages without altering sipsc amplitude western blot analysis kor expression indicated kor levels different two ages either bla cea first study provide compelling evidence novel unique neuromodulatory switch one primary brain regions involved initiating mediating anxiety may contribute ontogenic rise anxiety disorders elsevier ltd rights reserved
anxiety common among postpartum women adverse effects mother child somatic psychological health left untreated nurses midwifes specialisation community public health nursing also called health visitors hvs work families children younger years age therefore key position identify support women postpartum mental health issues recently postpartum mental health support provided hvs mainly focused identifying managing depression updated clinical guidance national institute health care excellence also includes guidance regarding screening psychological interventions perinatal anxiety study therefore aimed explore hvs experiences supporting women postpartum anxiety views currently available care using qualitative approach depth semi structured interviews conducted hvs may october participants interviewed person workplace phone skype using thematic analysis four main themes emerged identification screening issues importance training service usage status current service provision women postpartum anxiety commonly encountered hvs clinical practice described often heavily using related healthcare services puts additional strain hvs already heavy workload issues identifying screening postpartum anxiety raised current lack perinatal mental health training hvs highlighted addition hvs described current lack good perinatal mental health services general specifically anxiety study highlights need perinatal mental health training general postpartum anxiety specifically well better coverage specialist mental health services need development interventions targeted postpartum anxiety
anxiety common treated primary care behavioral health providers embedded primary care help address treatment gap guidance anxiety treatment preferences would help inform tailoring clinical practice new interventions patient centered increase treatment engagement surveyed non treatment seeking veteran primary care patients male white age years reporting current anxiety symptoms generalized anxiety disorder questionnaire likelihood attending anxiety treatment featuring various levels attributes modality type location format provider visit frequency visit length treatment duration type psychotherapy symptom focus topic skill participants indicated clear preferences individual face face treatment primary care occurring month least min lasting least three sessions also tended prefer stress management approach focused trouble sleeping fatigue topics skills rated equivalently attributes highest rated options consistent characteristics integrated care implications research practice discussed
application multifrequency magnetic resonance elastography mmre brain parenchyma patients neuromyelitis optica spectrum disorder nmosd compared age matched healthy controls nmosd patients age gender matched examined using mmre two three dimensional viscoelastic parameter maps magnitude phase angle phi complex shear modulus reconstructed simultaneous inversion full wave field data isotropic resolution harmonic drive frequencies nmosd patients significant reduction observed within white matter fraction predominantly within thalamic regions compared parameters exceeded reduction brain volume measured patients versus whole brain volume reduction volumetric differences white matter fraction thalami detectable patients however phase angle phi decreased patients within white matter thalamic regions mmre reveals global tissue degeneration accelerated softening brain parenchyma patients nmosd predominant reduction stiffness found within thalamic region related white matter tracts presumably reflecting wallerian degeneration aeuro cent magnetic resonance elastography reveals diffuse cerebral tissue changes patients nmosd aeuro cent premature tissue softening nmosd patients indicates tissue degeneration aeuro cent hypothesis widespread cerebral neurodegeneration form diffuse tissue alteration
applying arguments social exchange theory theoretically derive empirically test multilevel model informs theory leadership cynicism deviant withdrawal namely examine moderating effect upward exchange relationship leader empowering leadership behaviors affect subordinate psychological empowerment cynicism time theft sample employees across direct supervisors empowering leadership associated reduced employee cynicism directly indirectly employee psychological empowerment positive relationship empowering leadership employee psychological empowerment however significant leader enjoyed high quality relationship boss turn cynicism associated increased time theft suggesting employees may reciprocate frustrating experiences withdrawing minor yet impactful deviant ways efforts balance exchange organization
appropriate site planning design spd key solution effective land use construction sites green building rating tool gbrt includes systematic assessment criteria evaluate whether building green effectiveness gbrts explored energy use waste management indoor air quality green buildings however investigation made evaluate effectiveness gbrts site planning design aspects research five international gbrts selected comparative analysis better understand measures help improve spd green buildings content analysis applied record compare relevant significance spd related items selected gbrts comparative study revealed terms spd building environmental assessment method beam plus allocates highest importance green mark allocates lowest gbrt emphasizes different aspects spd green buildings beam plus involves spd related items addition main variables effective spd identified theoretical framework proposed proposed theoretical framework serve foundation successful spd green buildings application potential limitations theoretical framework also discussed elsevier ltd rights reserved
appropriate structure first key issue designer efficient hybrid vehicle pay attention paper presents three different structures concept series parallel structure hybrid electric vehicles hevs compares application toyota prius well known case study first structure consisting one electric motor one electric generator one power split device conventional structure one existing toyota prius called ths literature second third structures based two special electric machines named transmotor based structure tbs dual mechanical port dmp machine based structure dmpbs respectively three structures compared considering different aspects weight occupied volume overall efficiency surface mounted fractional slot concentrated winding dmp machine designed design verified applying finite element analysis simulation results presented support accomplished comparison structures study simulation results show structures approximately equal weight volume efficiency dmpbs compact efficient simple way convert existing fossil fuel cars hev one dmp machine prototype implemented experimental results included
approximately patients treated depression respond trial antidepressant aim proposed study evaluate efficacy safety switching vilazodone patients major depressive disorder unresponsive partially responsive trial citalopram seventy nine adults major depressive disorder enrolled open label study citalopram day weeks still symptomatic weeks citalopram randomly assigned either higher dose citalopram day vilazodone double blind trial weeks received citalopram day weeks responders defined reduction montgomery angstrom sberg depression rating scale respond assigned citalopram day randomized day vilazodone groups showed decreases outcome measures significant differences groups initial nonresponders low dose citalopram seem equally likely respond higher dose citalopram vilazodone whether increase selective serotonin reuptake inhibitor switch different antidepressant may best determined basis adverse event profile
approximately thyroid cancers medullary thyroid carcinomas mtc mtc mainly sporadic nature cases hereditary genetic testing hereditary mtc important patient family patients must receiving appropriate genetic counseling patients hereditary mtc germline mutations exons intron rearrangement transfection ret proto oncogene etiology frequent sporadic form mtc smtc well understood recently reported apparently sporadic mtc may involve point mutations braf ras genes overall prevalence almost also alteration abnormal expression mirna described mtc review attempted mention mutations molecular changes sporadic hereditary mtc pathogenesis
aptamers short single stranded nucleic acids fold well defined three dimensional structures allow binding target molecule affinities specificities rival cases exceed antibodies compatibility aptamers nanostructures thin films combination affinity selectivity conformational changes upon target interaction could set foundation development novel smart materials study development biocompatible aptamer polyelectrolyte film system investigated using layer layer approach using fluorescence microscopy demonstrated ability sulforhodamine aptamer bind cognate target sequestered chitosan hyaluronan film matrix studies using ultraviolet visible vis spectrophotometry also suggest deposition conditions rinsing time volume play strong role internal film interactions growth mechanisms chitosan hyaluronan films continued study development aptamer functionalized thin films provides endless new opportunities novel smart materials potential revolutionize field controlled release
aquaporin aqp important salivary fluid secretion found acinar cells salivary glands several species recently studies shown aqp transcript protein expression patterns well temporal spatial protein distribution development mouse submandibular salivary gland aqp distribution pattern closely located sublingual gland slg however well known thus study aqp rna expression pattern temporal spatial distribution aqp protein prenatal development adult mouse slg investigated slgs embryonic day postnatal days examined using real time pcr immunohistochemistry aqp transcript detected found increase towards birth young adults protein first detected scattered pattern canalicular stage became organized luminal membrane acinar cells towards birth postnatal developmental stages studied aqp localized luminal lateral membrane acinar cells aqp also detected intercalated duct additional apical membrane staining entire intralobular duct found terminal bud stage results indicate aqp plays role embryonic salivary gland development
archivedb data archive scientific technical data collected wendelstein project distributed system allowing continuous data archival archivedb demanding requirements regarding performance efficiency storage performance experiments expected storage amount year reliability availability days year maintainability testability portability including change hardware software data acquisition continuous operation high time resolutions nanoseconds scale physics data supported well long term recording days operational data similar rate moreover results data analysis stored archive another challenge uniform retrieval measured analyzed data allowing time structure information selection criteria mastered well key concepts data storage retrieval partitioning incoming data groups stream chunking data boxes manageable size covering finite time period indexing data using absolute time ordering indexing criteria continuous operation archivedb software hardware various systems components relevant wendelstein done successfully several years thus showing key requirements satisfied overall data amount far reached terabyte years data taking round clock operation archive place since years initial plasma operation wendelstein supported downtime whole experimental campaign paper describes software engineering concepts used consolidated refined years continuing productive archivedb use development changes underlying techniques change data store encapsulated via application programming interface api api unifies different implementations also suitable data migration elsevier rights reserved
arcuate neurons coexpress kisspeptin kiss neurokinin tac dynorphin pdyn mediate negative feedback beta estradiol hpg axis previous studies report fasting caloric restriction reduce arcuate kiss expression objective study determine interactions fasting caloric restriction diet induced obesity kndy gene receptor expression ovariectomized female mice separated control estradiol benzoate treated groups decreased kiss tachykinin receptor tacr arc tissue tact tac neurons diet induced obesity decreased kiss oil treated animals kisspeptin receptor kissr tacr arc treated animals chronic caloric restriction reduced three neuropeptides oil treated females kissr animals taken together experiments suggest steroidal environment energy state negatively regulate kndy gene expression arc tac neurons elsevier ireland ltd rights reserved
arginine semi essential amino acid affects physiological biochemical functions cpa gene yeast encodes large subunit arginine specific carbamoyl phosphate synthetase cps involved arginine biosynthesis ortholog yeast cpa identified rice blast fungus magnaporthe oryzae named mocpa mocpa amino acid protein contains atp grasp domain two cpsase domains targeted deletion mocpa supported role novo arginine biosynthesis oryzae mutant phenotypes complemented arginine ornithine delta mocpa mutant exhibited defects asexual development pathogenicity appressorium formation examination revealed invasive hyphae delta mocpa mutant restricted mainly primary infected cells addition delta mocpa mutant unable induce plant defense response ability scavenge ros pathogen plant interactions structure analysis revealed atp grasp domain cps domain indispensable proper localization full function mocpa summary results indicate mocpa plays important role arginine biosynthesis affects growth conidiogenesis pathogenicity results suggest research metabolism processes mediate amino acid synthesis valuable understanding oryzae pathogenesis
aristotle politics discusses territorial size city state division land public private size population desired per citizen product determined basis concept good life paper elements combined construct model describes long run equilibrium position economy city state position determined optimal land population ratio reached changes population means birth control policies
aroma rice greatly affects palatability well consumer acceptability one main factors rice quality work gas chromatography mass spectrometry used investigate volatile organic compounds voc rice samples different storage time found compounds benzaldehyde fluoro methylaniline increased remarkably storage hexanal octaethylene glycol monododecyl ether continuously decreased colorimetric sensor array composed sensitive dyes used rice sample discrimination ccd camera employed capture images colorimetric sensor array difference map sensor array exposure voc obtained red green blue components images extracted difference map moreover images processed turned digital data subsequent analysis recently harvested rice stored months samples distinguished three dimensional spaces personal computer assistant cluster trend linear discriminant analysis lda model based pca scores used discriminate storage time rice samples result indicates samples correctly identified
artificial synaptic devices implemented emerging post cmos non volatile memory technologies resistive ram rram made great progress recently however still big challenge fabricate stable controllable multilevel rram benefitting control electron spin instead electron charge spintronic devices magnetic tunnel junction mtj binary device explored neuromorphic computing low power dissipation paper compound spintronic device consisting multiple vertically stacked mtjs proposed jointly behave synaptic device termed compound spintronic synapse css based theoretical experimental work demonstrated proposed compound spintronic device achieve designable stable multiple resistance states interfacial materials engineering components additionally compound spintronic neuron csn circuit based proposed compound spintronic device presented enabling multi step transfer function spin artificial neural network asann constructed css csn circuit conducting system level simulations mnist database handwritten digital recognition performance asann investigated moreover impact resolution css csn device variation system performance discussed work
technology including computer graphics virtual reality printing rapidly developed past years models gaining increasingly huge demand traditional modeling platforms maya zbrush utilize windows icons menus pointers wimp interface paradigms fine grained control construct detailed models however modeling progress tedious frustrating thus hard novice user even well trained artist therefore intuitive interface needed sketch intuitive communication modeling tool human beings becomes first choice modeling community far various sketch based modeling systems created studied paper attempt show systems work give comprehensive survey review categorize systems four aspects input knowledge use modeling approach output also discuss inherent challenges open problems researchers future
basic method monitoring activities internet applications traffic identification important internet management security internet traffic data naturally exhibits imbalanced distributions problem rarely considered research community data gravitation based classification dgc new classification model handling imbalance data sets proposed imbalanced dgc idgc model previous study present study developed idgc based model resolve imbalanced internet traffic identification problems first constructed six imbalanced traffic data sets three original traffic data sets extracted early stage features according packet sizes identification experiments compared performance six standard algorithms including dgc four imbalanced algorithms idgc experimental results demonstrated standard classification models could achieve high accuracy imbalanced traffic data imbalanced performance good generalizability also problem contrast idgc performed well stable manner terms imbalanced performance measures thereby demonstrating effectiveness imbalanced traffic identification elsevier rights reserved
first step toward development closed loop medical cyber physical systems paper presents monitor blood oxygen concentration predicts critical drops oxygen levels caused pulmonary shunts infants although blood oxygen concentration one closely monitored vital signs modern operating rooms measured noninvasively currently monitored time delayed proxy hemoglobin oxygen saturation predict sharp drops blood oxygen concentration employ available noninvasive respiratory measurements build parameterized physiological model circulation gases cardiopulmonary system since model parameters metabolic rate unknown vary greatly across patients utilize parameter invariant detector designed provide constant false alarm rate different patients regardless values parameters robust missing measurements finally evaluate performance detector real patient data collected surgeries performed children hospital philadelphia evaluated patients experiencing drop blood oxygen concentration detector achieves detection rate potentially life saving early warning average addition achieves false alarm rate false alarms per hour tests across patients experience pulmonary shunt
method mechanical surface treatment shot peening widely used improve fatigue strength materials however influence residual stresses introduced shot peening depends stability stability residual stresses fatigue may studied two stages first cycle successive cyclic loading study stability development residual stresses first cycle strain controlled fatigue normalized steel investigated influence total strain amplitude loading direction studied residual stresses obtained using ray diffraction technique shown stability relaxation residual stresses depend amount direction loading stresses finite element modeling fem used rationalize experimental data good agreement experimental fem results observed doi
replacement mineral materials geotextiles pervasively used civil engineering provide separation filtration study aims recycle kevlar selvages preparation nonwoven geotextiles effects fiber types manufacturing processing examined terms pore size water permeability shear resistance bursting strength puncture strength test results statistical analyses indicate combination kevlar fibers three dimensional crimped polyester pet fibers low melting point pet lmpet fibers creates geotextiles small pore size good water permeability good shear resistance geotextiles prevent soil loss greater water permeability higher resistance sharp objects elsevier rights reserved
result assignment federal bureau investigation fbi behavioral science unit author consulted firsthand knowledge cases discussed cheit book came believe middle ground victims allege may true accurate may misperceived distorted may symbolic may contaminated false problem challenge however determine basically agrees much cheit sets forth seeds truth many allegations concerns confusing inconsistent definitions referred many backlash confused cheit refers book witch hunt narrative many professionals including possibly cheit seem fully aware wide diversity ways children sexually victimized author believes delayed reporting minimization recent cases involving catholic priests penn sate inaccurate stereotypes perpetuated child abuse idealists witch hunt narrative law enforcement perspective benefit would come cheit extensive research focused documenting allegations became bizarre inaccurate less alleged far ranging harm caused witch hunt narrative author opinion process witch hunt narrative caused long term damage discussed
result rapid growth popularity portable digital devices recent years power requirements computer operating systems used devices also rapidly increased complexity processing power increased compared systems based dram main memory pcm phase change memory new memory technology significantly reduce power consumption data stored pcm disappear device powered paper first discuss several pcm ram based hybrid systems systems amount read data influences design hybrid structure experiment section found almost data semi read
result peculiar features carbon nanotubes cnts emerging many areas nanotechnology applications cnt based technology increasingly proposed biomedical applications develop biomolecule nanocarriers bionanosensors smart material tissue engineering purposes following chapter latter application explored describing cnts considered ideal material able support boost growth proliferation many kinds tissues
special case quay crane scheduling problem unidirectional quay crane scheduling problem received attention paper analyze computational complexity unidirectional quay crane scheduling problem propose tighter mixed integer programming formulation next develop three makespan constrained models obtain risk averse solutions mitigate impacts ship instability solution infeasibility thus need revamp even reschedule plans comprehensive numerical experiments designed investigate benefits tighter formulation three optimization models risk aversion elsevier rights reserved
overlay cognitive radio transform domain communication system tdcs proposed support reliable communications low probability interception however research tdcs assume perfect synchronization simplify algorithm design paper present low complexity symbol timing offset sto carrier frequency offset cfo estimation method practical tdcs applications utilizing preamble consisted multiple identical training sequences sto estimated demodulation procedure cyclic code shift keying ccsk circular correlation performed utilizing fast fourier transform fft thus estimation procedure significantly simplified considerable complexity reduction analyzed compared two conventional methods simulation results demonstrates proposed sto cfo estimation scheme low complexity solution tdcs multipath rayleigh fading channels comparable estimation performance terms probability incorrect timing offset mean square error cfo
building information modeling bim systems continue widely adopted increasing demand active construction schedule management system advanced decision making capabilities example overlapping construction activities significant performance construction operations corresponding activities may deteriorate thus viable construction schedule formulated order minimize overlapping proximate construction activities active system regarded certain solution issue purpose study develop systematic methodology computer system optimal construction schedule simulation minimize overlapping activities enhancement project operational performance study centers identifying overlapping activities applying fuzzy theory analyzing risk levels schedule overlap issues addition genetic algorithm theory adopted minimization overlapping highly risky activities finally optimal construction schedule minimizes overlapping activities suggested optimal schedule visualized bim based four dimensional computer aided design cad environment cad system developed study includes fuzzy analysis functions schedule simulator case study actual project introduced validate effectiveness proposed methodology
captured proposed new definition epilepsy increasingly recognized disorder characterized enduring predisposition recurrent seizures explicitly also neurobiological cognitive psychological social consequences condition estimated million people worldwide ongoing seizures despite optimal management substantial proportion remission consequences comorbidities epilepsy major determinants quality life include mood disorders anxiety depression dose related longer term effects antiepileptic drugs including prenatal development bone health neurobehavioural effects whilst separating part underlying condition unrelated contributors potentially remediable difficult given range tools available assist screening management excuse least trying part standard care people epilepsy managing epilepsy well much controlling seizures needs recognized planning delivering services well prioritizing research
chronic kidney disease progresses slowly early detection effective treatment cure reduce mortality rate machine learning techniques gaining significance medical diagnosis classification ability high accuracy rates accuracy classification algorithms depend use correct feature selection algorithms reduce dimension datasets study support vector machine classification algorithm used diagnose chronic kidney disease diagnose chronic kidney disease two essential types feature selection methods namely wrapper filter approaches chosen reduce dimension chronic kidney disease dataset wrapper approach classifier subset evaluator greedy stepwise search engine wrapper subset evaluator best first search engine used filter approach correlation feature selection subset evaluator greedy stepwise search engine filtered subset evaluator best first search engine used results showed support vector machine classifier using filtered subset evaluator best first search engine feature selection method higher accuracy rate diagnosis chronic kidney disease compared selected methods
computer programming computational thinking become integrated instruction content teachers special educators need understand provide instructional supports wide range learners including students disabilities cross case analysis study examined supports two students disabilities initially disengaged computing activities received computing instruction data revealed students support needs computing activities specific rather supports specific students needs successful educational areas also successful sufficient although additional studies would need conducted ascertain transferability findings contexts students results contribute evidence students disabilities participate provided supports need areas curriculum present framework evaluating student engagement identify student specific supports needed refine emerging pedagogy facilitate full participation students offer list four implications practice based findings elsevier ltd rights reserved
emergency contraception pills become easily accessible general public women able purchase contraception less completely without guidance medical professionals public knowledge effective option copper red poor access difficult many women resorting familiar highly available pills rather alternative may better suit needs present interactive engaging mobile based application app aims increase awareness knowledge methods thereby support user informed choice goal app make choice user rather enable user make well informed decision
location aware applications location based services continue increase popularity data sources describing range dynamic processes occurring near real time multiple spatial temporal scales becoming norm time existing frameworks useful understanding dynamic spatio temporal data time geography unable scale high volume velocity variety emerging data sources paper introduce computational framework turns time geography scalable analysis tool handle large rapidly changing datasets hierarchical prism tree hpt dynamic data structure fast queries spatio temporal objects based time geographic principles theories takes advantage recent advances moving object databases computer graphics demonstrate utility proposed hpt using two common time geography tasks finding similar trajectories mapping potential space time interactions taking advantage open data space time vehicle emissions envirocar platform
networks applications growing fast data generated transmitted leaving vulnerable modification besides significance sensitivity preciseness information cause big security issue increasing needs keep safe one proper solution problem cryptography technique used transform data unrecognizable information useless unauthorized person main core network security since new attacks techniques daily invented ciphers constantly test cryptanalysis attacks harden safety paper contains fair comparison serval ciphers speed test different platforms also performance risk globalize vision fast safe algorithm
obesity rates continue rise effective prevention treatment programs urgently required combating obesity requires weight management programs accessible scalable large numbers people growing evidence commercial programs combine behavior change techniques key motivators changing habits effective first line helping people adopt healthier dietary activity patterns particular digital programs potential provide service large numbers people widely accessible cost effective individual however date digital programs relatively utilized evaluated little published evidence performance programs large scale outside partnerships primary care participants self refer pay nominal fee purpose following study examine interrelated effect motivation opportunity ability behavioral outcomes digital commercial weight management program address aim thematic content analysis participants qualitative responses habits learned changes adopted conducted findings reveal habits learned changes adopted result participating program influence weight loss outcomes health well outcomes well
social movements relying weak ties found social networks spread around world researchers taken several approaches understanding networks function instances arab spring social scientists primarily relied survey content analysis methodology network scientists used social network analysis research combines content analysis automated techniques network analysis determine roles played using twitter communicate turkish gezi park uprising based network analysis nearly million tweets content analysis subset tweets found information sharing far common use tweets retweets tweets indicated leadership movement constituted small percentage overall number tweets using automated techniques experimented coded variables content analysis compute discriminative tokens predict values variable using textual information achieved precision identifying types shared information results detecting position user protest purpose tweets achieved precision respectively illustrating necessity user cooperation shortcomings automated techniques based annotated values user tweets computed similarities users considering information production consumption user similarities used compute clusters individuals similar behaviors interpreted average activities groups
summarized first article continuing medical education series currently available epidemiologic data suggest psoriasis may risk factor cardiometabolic disease emerging data also suggest associations psoriasis comorbidities beyond psoriatic arthritis including chronic kidney disease inflammatory bowel disease hepatic disease certain malignancies infections mood disorders recognizing comorbid disease burden psoriasis essential ensuring comprehensive care patients psoriasis clinical implications comorbid diseases associated psoriasis recommendations clinical management reviewed article
area software engineering matures role human factors software development commonly recognized important increasingly see empirical studies investigate connection example personalities preferences attitudes performances software engineers statistical analysis holds key role providing means uncovering associations various facets human factors behavioral effects projects outcomes traditional statistical techniques tend explore interpret multidimensional personality behavioral data average point perspective targeting central trends paper introduces methodology statistical tools provide new different perspective type data seeks boundaries psychometric dataset discovers reference benchmark personalities archetypal personalities method examines placement individuals dataset relation archetypes furthermore preference characteristics generally types behavioral data analyzed respect archetypes case exemplify methodology analyze personality project preference data master level students compare previous average point statistical analysis data also discuss archetypal analysis heart proposed methodology combined multi correspondence analysis might general use empirical
detection methods covert channels provide better way detect existence advanced persistent threat become hot research topic field network security although existing methods achieve feasible performance detecting jitterbug covert timing channel ineffective covert timing channels implemented sparse embedding especially low embedding probability paper new method detect jitterbug covert timing channel sparse embedding proposed timing intervals first modeled histogram statistics kolmogorov smirnov statistic used detection addition diversifications references model updating scheme practical usage analyzed experimental results show proposed method effective embedding probability existing methods effective embedding probability larger copyright john wiley sons ltd
elderly population rapidly expanding needs adequate health housing services elderly people continue grow resources providing services becoming increasingly scarce thus using modern technologies efficiently providing intelligent home care ihc services regarded pressing issue order handle issues coming aging society article analyzes health monitoring health prevention health advisor knowledge service requirements ihc platform proposes architecture ihc platform based chronic disease knowledge management excepted offer intelligent accurate personal care service elderly people
network size grows becomes difficult understand entire network complex network theory used analyze characteristics current network trust management schemes suggested understand entire network security situation results paper reveal order solve security problem complex network reliably security policy needs established prevent hub infected
physiological impact chronic stress difficult study humans naturalistic stressors invaluable sources information area review systematically evaluates research literature examining biomarkers chronic stress including neurocognition informal dementia caregivers identified papers inclusion final review including papers examining differences caregivers controls well interventions aimed counteracting biological burden chronic caregiving stress results indicate cortisol increased caregivers majority studies examining biomarker mixed evidence differences epinephrine norepinephrine cardiovascular markers high level heterogeneity immune system measures caregivers performed poorly attention executive functioning tests mixed evidence memory performance interventions reduce stress improved cognition mixed effects cortisol risk bias generally low moderate given rising need family caregivers worldwide implications findings longer neglected elsevier ltd rights reserved
processing control sensory evaluation green tea highly subjective tea industry highly professionalized desirable find objective way evaluating quality tea found paper two models set using mlp rbf neural networks sensory quality prediction model using eleven parameters measured processing variables leaf temperature moisture content etc sensory quality evaluation model using fourteen parameters related green tea variables image information set overall results suggested leaf temperature moisture content measured production could effectively predict sensory quality green tea parameters image information green tea able effectively evaluate sensory quality compared mlp neural network rbf model displayed much greater accuracy prediction model reducing relative error institution chemical engineers published elsevier rights reserved
research ambient assisted living aal matures expect data generated aal iot devices benefit analysis well established machine learning techniques also potential new research artificial intelligence used data generated sensors used aal paper present survey research related topics identify shortcomings propose future work integrate fields collecting ambient sensor data process data framework detect classify activities
stages emergency response shift important task early stage emergency response handle emergency supply collection fuzzy demand multi hub collection network taking consideration constraints limit collection time capacity constraint single hubs different demand levels met collection paper aims establishing mathematic planning model two objectives namely shortest collection time optimal collection cost terms algorithm design sequential enumeration method sem employed solve model higher iteration efficiency lower difficulty level algorithm first step find optimal collection time collection route allocation program direct shipment mode hub spoke mode mixed mode three modes compared terms collection route planning shortest collection time shortest collection route optimal collection cost entire collection network numerical example showed compared simulated annealing algorithm result sem basically algorithm however sem simpler practical easier operate better promotional value
urbanisation land development rapidly increase water quality stress due urban stormwater runoff becoming increasingly prominent problem although variety technologies exist improve urban runoff quality ultra urban areas pose specific challenge geotextile filters easy maintain long lifespan alternative sand filters urban areas demonstrated previous laboratory studies study examines field effectiveness geotextile filter means stormwater runoff treatment maryland results indicate filter able significantly reduce total suspended solids tss concentrations parking lot stormwater storms analysed tss demonstrated event mean concentration emc less target value however significant reduction total phosphorus emc occurred filters porosities characteristic pore opening sizes field exhumed geotextiles dropped accompanied comparable permittivities however final hydraulic conductivities field exhumed geotextiles still times higher typical unclogged uniform sand stormwater tss geotextile modelling developed earlier study successful predicting hydraulic conductivity decrease field
ascospores frequently found airborne fungal spores recognized various areas important cause respiratory allergies main objective study determine relationship airborne ascospores meteorological parameters using multivariate canonical correspondence analysis cca spearman correlation aerobiological monitoring fungal spores performed years using burkard volumetric spore traps seven main types ascospores identified leptosphaeria pleospora venturia diatrype chaetomium sporormiella ascobolus cca results showed applied variables accounted total variance spore data years largest contribution total variance explained period maximum air temperature effect meteorological factors varied among years highest values total variance spore data explained statistically significant variables observed highest contribution minimum relative humidity ascospores showed positive statistically significant correlation relative humidity rainfall contrast ascospores chaetomium negatively correlated precipitation relative humidity positively temperature based results epidemiological allergological studies must deserve attention estimate allergenic potential ascospores
aspergillus flavus fusarium primary causative agents keratitis results corneal tissue damage leading vision loss particularly individuals tropical parts world proteins tear film collected control keratitis patients profiled compared total proteins control proteins patient tear identified mass spectrometry proteins found glycosylated patient tear glycosylated control tear tear proteins showed alterations glycosylation pattern infection complement system proteins proteins specific neutrophil extracellular traps proteins involved would healing found patient tear presence innate immune system proteins tear film patients supports previous data indicating involvement neutrophil complement pathways antifungal defense high levels wound healing proteins keratitis patient tear implied activation tissue repair infection early appearance host defense proteins wound healing response indicates tear proteins could used early marker system monitoring progression pathogenesis identification negative regulators defense pathways keratitis tear indicates intricate balance pro anti defense mechanisms operating fungal infection eye significance tear proteins control mycotic keratitis patients separated glycoproteins non glycosylated proteins identified mass spectrometry tear proteins keratitis patients showed alteration glycosylation pattern indicating alteration glycosylation machinery due infection neutrophil extracellular traps specific proteins complement pathway proteins well wound healing proteins found patient tear showing activation antifungal defense patient tear negative regulators defense pathways also found patient tear indicating fine balance pathogen clearance host tissue destruction fungal infection depending upon individual specific host pathogen interaction understanding could used predict progression outcome infection elsevier rights reserved
assessment physical properties agricultural food products always major importance purpose study investigate possibility estimating physicochemical properties raw cane sugars using digital image processing colorimetric measurements various characteristics raw cane sugars ash sucrose invert sugar solution color starch dextran moisture refractive index iranian imported raw cane sugar samples examined additionally images samples captured flat scanner different morphological characteristics area perimeter squareness count number crystal determined using matlab software addition cie color coordinates spectroradiometer wavelength range measured results demonstrated good correlation certain morphological behaviors physicochemical properties raw cane sugars example relationships area mean dextran perimeter mean dextran squareness starch found moreover correlations certain physicochemical parameters ash sucrose invert sugar solution color dextran refractive index cie color coordinates values indicated determining physicochemical properties raw cane sugars appears feasible using digital image analysis technique
associations variability sympathetic nervous system arousal individual differences symptom severity examined children autism spectrum disorder asd thirty four families participated laboratory visit included continuous measurement electrodermal activity eda battery naturalistic structured parent child child alone direct testing tasks multiple indices eda considered greater variability eda associated higher levels asd symptoms findings generally consistent across tasks intellectual functioning moderate relation eda asd symptoms sympathetic arousal tendencies may represent important individual difference factor population future directions conceptualizations eda discussed
asthma one common chronic diseases childhood allergen sensitization high frequencies comorbid allergic diseases characteristic severe asthma children omalizumab anti ige mab first targeted biologic therapeutic approved treatment moderate severe persistent allergic asthma remains uncontrolled despite high dose inhaled corticosteroids plus controller medications since initial licensing use adults adolescents years age older clinical efficacy safety tolerability omalizumab demonstrated several published clinical trials children aged less years moderate severe studies supported approval pediatric indication use children aged years european medicines agency food drug administration recent change licensing review outcomes clinical trials children persistent receiving omalizumab therapy observational studies past years clinical experience europe data sources identified using pubmed guidelines management recommendations materials recent food drug administration pediatric advisory committee meeting also reviewed
asthma chronic obstructive pulmonary disease cystic fibrosis idiopathic pulmonary fibrosis among common chronic diseases prevalence increasing diseases characterized secretion cytokines pro inflammatory molecules thought play critical role pathogenesis moreover immune cells particularly neutrophils macrophages dendritic cells well structural cells epithelial airway smooth muscle cells also involved pathogenic cycle diseases pressing need development new therapies pulmonary diseases particularly existing treatment shown reduce disease progression hmgb high mobility group box originally identified nuclear non histone protein dna binding domains secreted living dying cells regarded important endogenous danger signaling molecule besides signal tissue injury hmgb considered powerful mediator inflammation high levels hmgb found chronic lung diseases role hmgb respiratory diseases still elusive nevertheless studies suggest involvement cytokine pathogenesis nucleic acid based drugs nabds novel class pharmaceuticals including antisense oligonucleotides dna zymes rna interference mediated small interfering rna sirna used dampen expression disease causing genes therapeutic potential controlling chronic airway diseases due inherent difficulties example sensitivity endonucleases delivery vivo assured vectors non viral lipid polymer based nanosystems acquired much importance context review discuss emerging tools gene therapy chronic lung diseases particularly use sirna regulation critical molecules pathogenesis chronic lung diseases particular emphasis hmgb therapeutic target
astm standard test method determining average bonding peel strength top bottom layers needlepunched geosynthetic clay liners used index test quality control manufacturing geosynthetic clay liners gcls acceptance test delivery materials project title indicates normally used measure peel strength top bottom geotextile layers within gcl paper evaluates use test method measure peel strength thin film coating laminated gcl geotextile adhered paper also shows moisture content hydrating conditions affect peel strength products
astronomy rich tradition using color photography imaging visualization research well sharing scientific discoveries formal informal education settings public outreach modern era astronomical research benefitted tremendously electronic cameras allow data images generated analyzed purely digital form level precision previously possible advances image processing software also enabled color composite images made ways much complex darkroom techniques optical wavelengths across electromagnetic spectrum internet made possible rapidly disseminate images eager audiences alongside technological advances gains understanding make images scientifically illustrative well aesthetically pleasing studies also given insights public interprets astronomical images different professional astronomers understanding differences help creation images meaningful groups invited review discuss techniques behind making color composite images well examine factors one consider whether data visualization public consumption also provide brief history astronomical imaging focus origins modern era distribution highquality astronomical images public part nearly every professional observatory public outreach review relevant research expectations misconceptions often affect public interpretation images
birth newborn mammal undergoes transition sterile uterine environment constant nutrient supply microbe rich environment intermittent oral intake complex milk nutrients via gastrointestinal tract git functional challenges partly explain relatively high morbidity mortality neonates preterm birth interrupts prenatal organ maturation including git increases disease risk exemplary necrotizing enterocolitis nec associated closely git immaturity enteral feeding bacterial colonization infants nec may require resection necrotic parts intestine leading short bowel syndrome sbs characterized reduced digestive capacity fluid loss dependency parenteral nutrition review presents preterm pig translational model pediatric gastroenterology provided new insights important pediatric diseases nec sbs describe protocols delivery care handling preterm pigs show immature git responds delivery method different nutritional therapeutic interventions preterm pig may also provide sensitive model postnatal adaptation weak term piglets showing high mortality attributes preterm pig model include close similarities preterm infants body size organ development many clinical features thereby providing translational advantage relative rodent models git immaturity hand need sow surgical facility piglet intensive care unit clinically trained personnel may limit widespread use preterm pigs studies organ adaptation preterm pigs help identify physiological basis neonatal survival hypersensitive newborns aid defining optimal diet rearing conditions critical neonatal period
best field bilingualism dynamic discipline informed diverse perspectives carroll critical review situated within linguistics framework contends current research bilingual exposure language development suffers lack theoretical clarity makes little contribution understanding bilingual acquisition carroll push carroll towards greater precision thinking relation input outcomes important welcome challenge however also critical keep mind social context motivates much current research bilingual development leave room studies whose main goal provide answers societally important questions bilingual children health development
least since practically continuous somewhat fragmented discussion relevance management research discussion addressed practically fields management besides general management operations management project management construction management examined detail although many different proposals made rectify situation definitive resolution found paper argued prior analyses reached root causes irrelevance problem analysis recent history management research following novel findings reached first root cause irrelevance argued lie reports american business education written pierson gordon howell second proposed direction reports deficient several ways rejection production integral part organizations management perhaps damaging feature reports third current research management suffers variety immediate causes irrelevance insufficiently recognized scholarly community suggested reaching root causes irrelevance facilitate finding suitable cures
present many techniques available applicable wide range datasets provide effective way mine frequent pattern datasets use different kind data structures processing provide variations requirement time space generally traditional techniques restricted narrow area provide effective results specific environment requires continuous optimization updation dynamic data structure mapping shows effectiveness compared traditional techniques terms time space requirement processing
present users utilize authenticated key agreement protocol wireless sensor network wsn securely obtain desired information numerous studies investigated authentication techniques construct efficient robust wsns chang recently presented authenticated key agreement mechanism wsns claimed authentication mechanism prevent various types attacks well preserve security properties however discovered chang method possesses security weaknesses first mechanism guarantee protection password guessing attack user impersonation attack session key compromise second mechanism results high load gateway node gateway node always maintain verifier tables third session key verification process authentication phase end describe previously stated weaknesses occur propose security enhanced version wsns present detailed analysis security performance authenticated key agreement mechanism enhances security compared related schemes also takes efficiency consideration
paris conference countries accepted challenge fight green house gas emissions ghg next decades attempt stop global warming europe aim future new buildings aim nearly zero energy consumption highly material efficient whilst existing building stock refurbished rate annually numerous international scientific studies found timber framed buildings result lower ghg emissions steel concrete counterparts green building construction relative new timber products connection methods conquer market cross laminated timber products clt products allow fast cost effective execution building structural limitations disadvantages traditional timber frame construction overcome examples multi storey timber structures presented steps forward ministered development innovative timber fastener connections like self tapping screws reinforced dvw tube connections authors published elsevier ltd
atherosclerotic coronary artery disease result coronary artery stenosis acute coronary artery occlusion eventually myocardial infarction major cause morbidity mortality worldwide non invasive characterization coronary blood flow important improve understanding prevention treatment disease computational simulations produce clinically relevant hemodynamic quantities using non invasive measurements combining detailed three dimensional fluid mechanics physiological models multi scale framework models however require specification numerous input parameters typically tuned manually without accounting uncertainty clinical data hindering application large clinical studies propose automatic bayesian approach parameter estimation based adaptive markov chain monte carlo sampling assimilates non invasive quantities commonly acquired routine clinical care quantifies uncertainty estimated parameters computes confidence local predicted hemodynamic indicators elsevier ltd rights reserved
atopic dermatitis chronic relapsing highly pruritic skin condition resulting disruption epithelial barrier associated immune dysregulation skin genetically predisposed hosts generally develops early childhood characteristic age dependent distribution commonly associated elevated ige peripheral eosinophilia allergic diseases medications antihistamines demonstrated poor efficacy controlling associated itch education patients regarding primary underlying defects provision comprehensive skin care plan essential disease maintenance management flares
atopic dermatitis common chronic inflammatory skin disease predominantly affects children however persist adulthood start older ages due chronic nature frequently occurring relapses substantial effect patients quality life often requiring long term systemic treatment especially adult patients frequently refractory adequate topical treatment mid high potent corticosteroids calcineurin inhibitors therefore treatment systemic therapies often needed take control disease prevent exacerbations improve quality life however data regarding systemic treatment effectiveness long term safety adult patients insufficient indeed standardized international guidelines lacking treatment approach widely differs among diverse countries review focuses use systemic treatments adult patients analyzing published literature
atopic dermatitis known aggravate thymic stromal lymphopoietin tslp tslp also known regulate mast cell proliferation via production interleukin thus investigated whether cordycepin could regulate mast cell proliferation induced tslp human mast cell line hmc cell cordycepin significantly diminished production mrna regulation phosphorylated signal transducer activation transcription tslp stimulated hmc cells cordycepin also significantly diminished cell proliferation via regulating mdm levels regulating caspase cleaved poly adp ribose polymerase levels tslp stimulated hmc cells moreover cordycepin significantly diminished production tumor necrosis factor alpha beta tslp stimulated hmc cells conclusion study shows cordycepin potential effect treatment allergic inflammatory diseases blockade mdm exacerbated tslp
atrial fibrillation significantly increases risk stroke disease burden established predictor poor outcomes stroke however data regarding sex differences long term outcomes following stroke patients scarce thus aimed assess differences recruited consecutive patients acute ischemic stroke non valvular atrial fibrillation nvaf treated three hospitals tianjin china january september information regarding stroke subtype severity risk factors outcomes mortality dependency recurrence months stroke recorded prevalence nvaf overall higher frequency women men among patients nvaf women older men women likely men severe stroke high levels total cholesterol high low density lipoprotein cholesterol hypertension dyslipidemia obesity less likely men current smokers consume alcohol greater risks dependency recurrence months stroke women men odds ratios confidence intervals dependency recurrence adjustment stroke subtype severity risk factors findings suggest crucial emphasize need individualized stroke prevention education promotion healthy lifestyles order improve nvaf related stroke outcomes reduce disease burden women
attention important cognitive behavioral process means individual able focus single aspect information ignoring others time drawn notifications beeps vibrations blinking messages ability focus becomes increasingly important true many different domains workplace classroom paper present non intrusive distributed system monitoring attention teams people especially suited teams working computer presented system able provide real time information individual well information team useful team managers identify potentially distracting events individuals well detect onset mental fatigue boredom significantly influence attention overall tool may prove useful team managers implement better human resources management strategies
attentional lapses usually defined temporary often brief shifts attention away primary task unrelated internal information processing study addressed incidence attention lapses differences attentional functioning children attention deficit hyperactivity disorder adhd healthy children children spina bifida myelomeningocele hydrocephalus sbh assessments conducted using computerized tonic phasic attention tests symbol digit modalities test sdmt trail making test form tmt group sbh differed normal controls cognitive measures attention executive functions adhd group obtained lower scores sbh group healthy children anova results showed effect shunt revisions shunt related infections neuropsychological performance lapses attention together reaction time may thus represent important factors understanding cognitive deficits sbh
attribute reduction one fundamental important topics rough set theory uncertainty measures play important role attribute reduction classical rough set model uncertainty measures monotonicity respect granularity partition however monotonicity uncertainty measures hold uncertainty measures classical rough set model directly extended probabilistic rough set model makes reasonable use evaluate uncertainty probabilistic rough set model moreover monotonicity important constructing attribute reduction algorithms monotonicity uncertainty measures simplify algorithm design paper focuses constructing monotonic uncertainty measures probabilistic rough set model firstly analyze non monotonicity problem uncertainty measures probabilistic rough set model secondly propose three basic uncertainty measures three expected granularity based uncertainty measures monotonicity measures proved held relationship measures corresponding uncertainty measures classical rough set model also obtained finally new attribute reduct defined based proposed monotonic uncertainty measure corresponding heuristic reduction algorithms developed results experimental analysis included validate effectiveness proposed uncertainty measures new reduct definition elsevier inc rights reserved
audio forensics based fluctuations electrical network frequency enf become one major approaches authentication digital audio recordings yet little known circumstances preconditions battery powered devices leave enf artifacts recordings study multiple mobile recording devices confirms hypothesis background noise generated mains powered electronic devices proximity recording device carrier enf artifacts experiments indoor setting suggest high robustness indicate presence enf artifacts even multiple rooms apart noise source
auditory verbal hallucinations avh frequently occurring phenomenon general population considered psychotic symptom presented context psychiatric disorder neuroimaging literature shown avh subserved variety alterations brain structure function primarily concentrate around brain regions associated processing auditory verbal stimuli executive control functions however direction association avh brain function remains equivocal certain research areas needs carefully reviewed interpreted avh significant impact daily functioning several efficacious treatments attempted antipsychotic medication brain stimulation cognitive behavioural therapy interestingly neural correlates treatments largely overlap brain regions involved avh suggests efficacy treatment corresponds normalization avh related brain activity selected review give compact yet comprehensive overview structural functional neuroimaging literature avh special focus neural correlates efficacious treatment
austin texas one worst places respect allergies winter mountain cedar juniperus ashei producing high pollen amounts exerting called cedar fever individuals allergic pollen species study evaluated extent effect prescribed fires semi arid ecosystem decreases pollen concentrations local scale study performed patches characterized human induced fire disturbances unmanaged areas control sites southwest austin pollen sampled four consecutive days january using ten pollen traps installed microscope slides inserted every second hour station equipped meteorological devices account influencing factors wind speed direction mean cedar pollen concentrations differed across studied days plots ranged january pollen grains january determined diurnal patterns peak values pollen concentrations average lower burnt control plots comparing pairs adjacent plots even revealed reduction therefore local land management alter pollen concentrations drastically walk across previously burnt areas may trigger less severe symptoms allergic people flowering period mountain cedar results add knowledge individual cedar pollen exposure heterogeneous areas help improving mitigation strategies elsevier rights reserved
autism considered today neurological development disorder appears early infancy characterized social interaction difficulties communication problems reduced repetitive behavioral patterns interests activities paper presents bibliographic review different treatments currently deal communication difficulties children disorder two axis conceptual basis approaching modalities underlying theoretical perspectives one hand two different ways approach defined according objectives pursued practice educative therapeutic modalities hand practices according theoretical framework support presented related cognitive behavioral theory based psychoanalysis introduces importance subject social ties objective article analyze contributions limitations different theoretical approaches presented detailing scope achieved regarding aforementioned diagnosis
autism spectrum disorder asd affects individuals across racial ethnic groups yet rates diagnosis disproportionately higher black hispanic children caregivers children asd experience significant stressors associated parental strain inadequate utilization mental health services lower quality life family peer advocate fpa model utilized across service delivery systems provide family family support facilitate engagement increase access care study used randomized controlled design examine efficacy fpas racially ethnically diverse sample results demonstrate significantly increased knowledge asd reduced levels stress caregivers received fpa intervention compared treatment usual
autism spectrum disorder asd neurodevelopmental disorder atypical cortical maturation leading deficiency social cognition language numerous studies attempted classify asd using brain measurements cortical thickness surface area volume promising results however underpowered sample sizes studies limit external validity generalizability population level large scale collaborations enhancing neuroimaging genetics meta analysis enigma autism brain imaging data exchange abide aim bring together like minded scientists improve investigations brain disorders best knowledge study represents largest classification analysis detection asd healthy age sex matched controls using cortical thickness brain parcellations intracranial volume normalized surface area subcortical volumes able increase classification accuracy overall females novel findings using evolving partitions improve connectomics epic underscore importance large scale data driven approaches collaborations discovery brain disorders
autism spectrum disorder asd pervasive neurodevelopmental condition characterized variable impairments communication social interaction well restricted interests repetitive behaviors heterogeneity presentation hallmark investigations immune system problems asd including aberrations cytokine profiles signaling increasing recent times subject ongoing interest aim establishing whether cytokines utility potential biomarkers may define subgroup asd function objective measure response treatment review summarizes role immune system discusses relationship immune system brain behavior presents previously identified immune system abnormalities asd specifically addressing role cytokines aberrations roles identification biomarkers also addressed particularly respect cytokine profiles asd
autism spectrum disorder asd commonly diagnosed neurodevelopmental disorder current estimates affected children across nations patients form highly heterogeneous group behavioral phenotype common genetic heterogeneity reflected plethora animal models representing multiple mutations found families affected children despite many years scientific effort majority cases genetic cause remains elusive therefore crucial include well validated models idiopathic autism studies searching potential therapeutic agents one models btbr itpr mouse current review summarizes data gathered recent research potential molecular mechanisms responsible autism like behavioral phenotype strain elsevier ltd rights reserved
autism spectrum disorder asd condition defined along continuum sociocommunicative difficulties associated unique patterns memory functioning including difficulties autobiographical memory refers memory information related self personally experienced events strong social function current paper reviews empirical studies assessing among individuals asd across lifespan results support children adults asd manifest difficulties characterized reduced specificity less elaborated detailed narratives lower coherence increased reliance scaffolding retrieval individuals asd also demonstrate intact certain memory indices show evidence using compensatory strategies facilitate retrieval results interpreted relation models typically developing broad memory theory well models information processing specific asd advance knowledge develops within context asd developmental psychopathology perspective applied consideration candidate processes underlying developing among individuals asd future research consider support mechanisms promote performance multiple ecological levels limitations clinical implications intervention future directions discussed elsevier inc rights reserved
autoantibodies aabs glycolytic enzymes aldolase alpha enolase glyceraldehyde phosphate dehydrogenase pyruvate kinase prevalent sera patients blinding retinal diseases paraneoplastic cancer associated retinopathy car non paraneoplastic autoimmune retinopathies well many autoimmune diseases car degenerative disease retina characterized sudden vision loss patients cancer serum anti retinal aabs review discuss widespread serum presence anti glycolytic enzyme aabs significance autoimmune diseases multiple mechanisms responsible antibody generation including innate anti microbial response anti tumor response autoimmune response released self antigens damaged inflamed tissue aabs enolase gadph aldolase exist single patient elevated titers suggesting participation pathogenicity lack restriction aabs one disease may related increased expression glycolytic enzymes various metabolically active tissues triggers autoimmune response generation aabs specificity several chronic autoimmune conditions car importance serum anti glycolytic enzyme aabs previously dismissed retina may without pathological consequence failure blood retinal barrier function would allow pathogenic aabs access retinal targets ultimately leading damaging effects
autoinflammatory diseases aids genetically heterogeneous group diseases caused mutations genes encoding proteins play pivotal role regulation inflammatory response pathogenesis aids role genetic background triggered environmental factors modulation innate immune system monogenic aids characterized mendelian inheritance caused highly penetrant genetic variants single genes last years remarkable progress made identification disease associated genes using new technologies next generation sequencing allowed genetic characterization undiagnosed patients sporadic cases means targeted resequencing gene panel whole exome sequencing review delineate genetics monogenic aids report role common gene mutations describe evidences sound genotype phenotype correlations aid
automated regulatory contractual compliance checking requires automated rule extraction regulatory contractual textual documents contract specifications automated rule extraction challenging task requires complex processing text proposed automated compliance checking acc approach first step automating rule extraction process automatically classifying different documents parts documents contract clauses predefined categories environmental safety health etc preparing text analysis rule extraction categories defined semantic model normative reasoning paper presents semantic machine learning based text classification algorithm classifying clauses subclauses general conditions supporting acc construction multilabel classification problem transformed set binary classification problems different machine learning algorithms text preprocessing techniques methods text feature scoring methods feature weighting feature sizes implemented evaluated different thresholds developed classifier achieved recall precision respectively testing data american society civil engineers
automated regulatory compliance checking requires automated extraction requirements regulatory textual documents formalization computer processable rule representation information extraction challenging task requires complex analysis processing text natural language processing nlp aims enable computers process natural language text human like manner paper proposes semantic rule based nlp approach automated construction regulatory documents proposed approach uses set pattern matching based rules conflict resolution rules variety syntactic syntax grammar related semantic meaning context related text features used patterns rules phrase structure grammar psg based phrasal tags separation sequencing semantic information elements proposed used reduce number needed patterns ontology used aid recognition semantic text features concepts relations proposed algorithms tested extracting quantitative requirements international building code achieved precision recall respectively american society civil engineers
automatic detection brain tumors single spectral magnetic resonance images challenging task existing techniques suffer inadequate performance dependence initial assumptions sometimes need manual interference research reported paper seeks reduce shortcomings remove others achieving satisfactory performance reasonable computational costs success system described explained synergy following aspects broad choice high level features characterize image texture efficient mechanism eliminate less useful features machine learning technique induce classifier signals presence tumor affected tissue improved version skippy greedy snake algorithm outline tumor contours paper describes system reports experiments synthetic well real data elsevier ltd rights reserved
automation processes design final component manufacturing poses numerous challenges problems need addressed tolerances geometry dimensional accuracy surface quality component first two addressed integrating computer aided design computer aided manufacturing machining systems real time monitoring performance estimation systems surface quality need developed approach work front end software developed input software surface image machined workpiece taken camera image processed image processing module mat lab texture feature extraction namely curvelet transforms data software turn classifies machining processes undergone according trend curvelet transform data sends corresponding process model estimation machining performance work software tested sample test data displayed machining process accurately estimated machining performance results encouraging method used real time estimation machining process machining performance elsevier gmbh rights reserved
automotive materials core course master engineering international automotive engineering program developed consultation industry representatives aims link material properties automobile design manufacturing requirements course content focuses niche areas component design including alternative materials topic presented relation particular application formal lectures combined case study materials selection projects deepen students knowledge understanding topic innovative aspect course curriculum case study approach properties materials discussed context particular applications approach enables students construct materials knowledge develop intrinsic motivation learn subject material course running four years positive student feedback
automotive systems widely used industry daily life reliability automotive systems becoming greater challenge community increasingly automotive companies interested applying formal methods improve reliability automotive systems focus automotive operating systems conforming osek vdx standard operating systems considered important components ensure reliability automotive systems previous work proposed framework verify design models reactive systems specifications framework allows check whether design model conforms specification based simulation relation paper shows case study framework applied real design osek vdx operating system result found able check several important properties design model show effectiveness practicality framework based results case study
autonomous adaptation self adapting embedded real time systems introduces novel risks may lead unforeseen system behavior anomaly detection framework integrated real time operating system ease identification suspicious novel behavior thereby offers potential enhance reliability considered self system however anomaly detection based knowledge normal behavior dealing self reconfiguring applications normal behavior changes hence knowledge base requires adaptation even construction runtime stringent restrictions real time systems considering runtime memory consumption make task really challenging problem present idea online construction application behavior knowledge rely training phase applications behavior defined application system call invocations knowledge base exploit suffix trees offer potentials represent application behavior patterns associated information compact manner online algorithm provided suffix trees basis construct knowledge base low computational effort anomaly detection classification integrated online construction method new behavioral patterns unconditionally update behavior knowledge base evaluated context related manner inspired danger theory special discipline artificial immune systems copyright john wiley sons ltd
autonomous landing become core technology unmanned aerial vehicle uav guidance navigation control system recent years novel autonomous landing approach computer vision studied applied rotary wing uav landing successfully paper aims fixed wing uav focus two problems find runway depending airborne front looking camera align uav designated landing runway paper divided two parts solve two problems respectively first part paper firstly presents algorithm region interest roi detection based spectral residual saliency map algorithm feature vector extraction based sparse coding spatial pyramid matching spm proposed finally roi including designated landing runway recognized linear support vector machine second part paper presents approach relative position pose estimation uav landing runway estimation algorithm firstly selects five feature points runway surface establishes new earth fixed reference frame finally uses orthogonal iteration estimate landing parameters including three parameters distance height offset three pose parameters roll yaw pitch experimental results verify effectiveness algorithms proposed paper
availability long term solar data quality available data usually obstacle development proposals new concentrating solar power plants typical representative meteorological years using hourly solar weather data selected match long term averages often used perform preliminary design performance assessment solar power plants although use data convenient due reduced computational requirements plant optimization may result simplistic prediction plant operations reflect real plant performance neglecting impact short term variability solar irradiance variations weather available solar energy different years study conducts systematic analysis influence multi year data sets range different time step sizes min thermal storage capacities using physical parabolic trough molten salt storage model nrel system advisor model results indicate appropriateness different step sizes likely vary depending purpose modelling however sensitivity step size reduced larger storage capacities crown copyright published elsevier ltd rights reserved
average happiness big cities inhabitants usa lower average happiness towns country adam kozaryn offers several explanations one explanation core characteristics cities size density heterogeneity lead deterioration social relations explanation insufficient average happiness cities also relatively high case poor nations compared happiness towns country important factors like relative safety availability services considered additionally second explanation capitalism plays dominant role cities similar negative effects explanation also insufficient negative effects capitalism limited cities plausible explanation average happiness american cities relatively low interaction core characteristics capitalism people live smaller places impossible many people big cities needed minimize ecological footprint overpopulation root problem discussion maximum size population needed reason fear negative impact individual freedom people pay attention discussion make mind children
azacitidine first class demethylating agent widely used globally first line treatment higher risk myelodysplastic syndrome mds report case patient mds suffered rare adverse event acute lung injury ali suspected caused azacitidine successfully treated corticosteroids rare critical adverse event clinicians consider ali one differential diagnoses cases pneumonia fever unknown etiology arise mds patients treated azacitidine antimicrobial agents effective microbiological tests produce negative results
azd non steroidal glucocorticoid receptor modulator low aqueous solubility developed treatment asthma copd work aim evaluate compare absorption pharmacokinetics azd inhalation via four devices spira neb turbuhaler new dry powder inhaler new dpi two formulations using differently sized primary particles compare pulmonary bioavailability predicted lung deposited dose plasma concentration time data intravenous oral inhaled administration via four devices available two clinical studies healthy asthmatic subjects population modelling approach taken sequentially incorporate route administration assuming parallel absorption compartments inhaled azd non compartmental analysis derivation parameters performed comparison pulmonary bioavailability varied devices lowest estimates neb turbuhaler highest new dpi spira pulmonary bioavailability substantially lower predicted lung deposited dose range lung absorption separated faster slower process model half life faster absorption appeared formulation dependent slower absorption half life appeared independent formulation large difference estimated pulmonary bioavailability predicted lung deposited dose azd implies impact mucociliary clearance lung absorption half life indicates azd retained lung relatively short time
back pain one major musculoskeletal pain problems affect many people considered one main causes disability world lower back pain common type back pain estimated affect least adult population united kingdom time lives patients develop serious condition namely chronic lower back pain physicians must carry involved diagnostic procedure determine cause cases procedure involves long laborious task physicians visually identify abnormalities patient magnetic resonance images limited technological advances made past decades support process paper presents comprehensive literature review technological advances presents framework methodology diagnosing predicting chronic lower back pain framework combine current state art computing technologies including area artificial intelligence physics modelling computer graphics argued able improve diagnosis process
background characteristics primary headaches patients ruptured brain aneurysm embolization well understood date aims study study conducted evaluate influence endovascular treatment evt ruptured intracranial aneurysm ria pattern previous primary headache methods evaluated pattern headache patients suffered ria evt within one year rupture prospectively evaluated characteristics headache months evt sixty patients evaluated questionnaire headache applied time admission patients contacted months treatment complete study filling follow questionnaire headache results thirty seven patients headache rupture tension type headache tth migraine without aura nine migraine aura one nonspecific characteristics significant reduction frequency pain months patients tth migraine without aura reduction pain intensity period tth migraine aura migraine without aura conclusion reduction primary headache endovascular treatment ruptured brain aneurysm
background aims acute rejection detrimental transplanted solid organs considered less consequence transplanted livers evaluated risk factors outcomes biopsyproven acute rejection bpar based analysis recent national sample recipients liver transplants living deceased donors methods analyzed data adult adult living donor liver transplantation cohort study aall exploratory cohort scientific registry transplant recipients srtr validation cohort examined factors associated time first bpar using multivariable cox regression discrete survival analysis competing risks methods used compare causes death graft failure recipients living deceased donors results least bpar episode occurred recipients aall recipients srtr database risk rejection significantly lower livers came biologically related living donors aall hazard ratio confidence interval srtr higher liver transplant recipients primary biliary cirrhosis younger age hepatitis database bpar associated significantly higher risks graft failure death risks highest month post bpar period patients whose first episode occurred year liver transplantation hrs graft failure aall srtr hrs death aall srtr analyses cause specific mortality associations observed liver related graft failure causes death causes conclusions contrary previous data acute rejection liver transplant associated significantly increased risk graft failure cause mortality graft failure related death regardless primary liver disease etiology living donor liver transplantation biologically related donor associated decreased risk rejection
background aims approximately one third patients present gastroenterology care constipation rectal evacuation disorders aimed compare rectal gas volume measured computerized tomography constipated patients without rectal evacuation disorders methods retrospective study wecollected data patients constipation evaluated years analyzed data patients evaluated anorectal manometry balloon expulsion tests colon transit tests collecting records abdominal pelvic examinations patients classified subgroups rectal evacuation disorders slow transit constipation normal transit constipation two observers used standard software identify variable regions interest cross sectional image contained rectum measured areas gas slice summated entire volumes rectal gas groups compared rectal gas volume maximal rectal gas transaxial area measured area rectal gas vertical dimensional abdominal film scout using kruskal wallis test results intraclass correlation coefficient observers measurements rectal gas volume overall group differences rectal gas volume maximal rectal gas transaxial area themedian rectal gas volumewas higher patients rectal evacuation disorders patients slow transit normal transit constipation similarly area rectal gas correlated maximal rectal gas transaxial area spearman correlation coefficient showed overall group differences greater areas rectal gas abdominal scout film patients rectal evacuation disorders normal transit constipation conclusions analysis patients constipation found rectal gas volume determined abdominal imaging greater patients without rectal evacuation disorders
background aims cryoglobulins circulating immune complexes polyclonal igg monoclonal igm rheumatoid factor detected circulation patients chronic hepatitis virus infection cryoglobulinemic vasculitis observed approximately patients aimed assess clinical immune effects direct acting antiviral treatment methods performed prospective study patients hcv infection circulating cryoglobulins receiving direct acting antiviral therapy single center barcelona spain january april patients classified asymptomatic circulating cryoglobulins acc clinical response considered complete patient birmingham vasculitis activity score version affected organs improved weeks end therapy complete immunologic response cir defined detection circulating cryoglobulins normalized levels complement rheumatoid factor results clinical manifestations included purpura weakness arthralgia myalgia peripheral neuropathy renal involvement baseline patients significantly higher levels rheumatoid factor lower levels complement patients acc whereas cryocrits similar groups overall patients sustained viral response weeks therapy among patients median birmingham vasculitis activity score version decreased range range twenty five patients achieved complete clinical response immune suppressive therapy reduced patients withdrawn overall patients achieved cir low baseline cryocrit level factor associated cir odds ratio confidence interval conclusions viral eradication associated clinical improvement patients markers immune activation including circulating cryoglobulins persisted patients acc despite sustained viral response weeks therapy longer follow period viral eradication might necessary ensure normal immune response
background aims data deficits lean body mass lbm total body skeletal muscle mass anorexia nervosa scarce inconsistent furthermore usefulness reported body mass index bmi severity cut tested respect important parameters study two aims namely study lbm patterns adult females weight restoration examine clinical usefulness bmi cut assessing protein status terms lbm patients methods body composition measured dual energy ray absorptiometry dxa weight gain adult female inpatients controls matched post treatment bmi age patients stratified two groups using bmi cut results weight restoration patients bmi displayed lower lean extremity mass percentage higher lbm significant differences lbm respect controls moreover time subgroup interaction significant terms lbm meaning changes occur different manner time two subgroups however differences found two subgroups either demographic eating disorder characteristics weight gain normalization lbm lbm lean extremity mass percentage achieved across entire sample bmi subgroup fat mass major determinant gain lbm higher baseline greater increase lbm conclusions results suggest bmi cut clinical threshold determining severity short term weight restoration associated normalization lbm appears biological regulation weight gain remains intact unaffected severity malnutrition elsevier ltd european society clinical nutrition metabolism rights reserved
background aims falls major threat patients parkinson disease associated higher risk morbidity loss functional ability institutionalization mortality metabolic syndrome mets associated poorer physical performance middle age impact older frailer subjects unclear present study aimed assessing association mets falls patients parkinson disease methods analyzed data elderly parkinson disease attending geriatric day hospital history falls occurred last year well number falls recorded metabolic syndrome diagnosed according national cholesterol education program atp iii criteria results falls reported participants logistic regression analysis showed mets associated reduced occurrence falls also among participants fell poisson regression indicated mets predicted reduced number falls irr conclusions population mets associated reduced probability falls among subjects fell mets associated reduced number falls dedicated studies needed better understand subsystems involved well therapeutic implications association elsevier ltd european society clinical nutrition metabolism rights reserved
background aims protein coupled receptor gpr recently orphanized estrogen receptor mediates effects estrogens different cells postulated inflammatory bowel diseases ibd activation gpr blocks pathways dependent pro inflammatory cytokines aim study investigate gpr expression patients ibd potential implication future therapies methods fifty seven patients enrolled study subjects crohn disease ulcerative colitis controls subject biopsies taken various left colonic locations gene protein expression gpr quantified using real time pcr western blot results gpr mrna protein expression detected tested colonic tissues significant differences gpr gene expression observed non inflamed areas gpr protein strongly increased patients moderately patients respectively controls patients significantly lower gpr protein content inflamed non inflamed tissue observed change independent patient gender conclusion observations indicate gpr may play role development progression inflammatory lesions ibd thus affecting disease severity consequently ibd treatment therefore gpr may become attractive target novel anti ibd drugs particularly
background aims little known prevalence burden undiagnosed celiac disease individuals younger age determined prevalence morbidity undiagnosed celiac disease individuals younger age community methods tested sera residents olmsted county minnesota without prior diagnosis celiac disease assay using assay iga tissue transglutaminase subjects positive test results celiac disease confirmed using assay endomysial iga performed nested case control study compare proportion comorbidities undiagnosed cases celiac disease age sex matched seronegative controls medical records abstracted identify potential comorbidities results identified adults positive results serologic tests based finding estimated prevalence celiac disease confidence interval children tested positive iga tissue transglutaminase confidence interval typical symptoms classic consequences diagnosed celiac disease diarrhea anemia fracture associated undiagnosed celiac disease undiagnosed celiac disease associated increased rates hypothyroidism odds ratio lower average cholesterol level ferritin level median follow period years cumulative incidence subsequent diagnosis celiac disease years testing persons undiagnosed celiac disease seronegative persons celiac disease status associated overall survival conclusions based serologic tests community population celiac disease estimated prevalence undiagnosed celiac disease undiagnosed celiac disease appeared clinically silent remained undetected long term outcomes determined
background aims treatments crohn disease linked serious infections malignancies dermatologic complications pooled analyzed clinical trials certolizumab pegol pegylated humanized fab fragment tumor necrosis factor quantify safety events patients methods collected data placebo controlled trials open label studies dose regimen study conducted globally april total patients moderate severe treated certolizumab pegol patient years exposure data analyzed groups patients placebo controlled trials treated placebo certolizumab pegol weeks group patients exposed certolizumab pegol durations weeks studies group incidence rates irs incidence patient years adverse events aes calculated first dose days approximately half lives last dose results group irs serious aes similar among patients given certolizumab pegol patient years placebo patient years irs serious infections malignancies low among patients receiving short term treatment certolizumab pegol patient years patient years respectively group increase long term treatment patient years patient years respectively studies group irs psoriasis psoriasiform dermatitis low group patient years patient years respectively placebo group irs per patient years per patient years respectively irs psoriasis psoriasiform dermatitis increase long term treatment patient years patient years respectively studies group conclusions based analysis data pooled trials patients safety profile long term therapy certolizumab pegol therapy similar reported short term studies overall rates aes serious infections malignancies psoriasis increase long term treatment suggesting favorable risk benefit ratio long term certolizumab pegol therapy
background objective rehabilitation focuses brain behavior relationship highlights interaction psychological neurobiological factors better patient care missing link literature socio cognitive aspects frontal lobe epilepsy objective examine prefrontal cortical functioning pcf empathic abilities patients frontal lobe epilepsy fle analyzed whether relationship components dispositional empathy pcf exists patients fle methods study designed experimental paradigm sixty patients fle recruited sheikh zayed jinnah hospital pakistan sixty healthy individuals response advertisement took part study control subjects participants completed interpersonal reactivity index following performed clock drawing test word color identification task switching experiment result patients fle demonstrated weaker pcf cognitive flexibility executive function compared healthy control subjects patients fle scored lesser cognitive empathy compared healthy control subjects contrary significant difference patient control group affective empathy cognitive affective empathy potential predictor pcf conclusion cognitive empathy significant marker prefrontal cortical functioning pcf fle higher cognitive empathy would lead efficient pcf
background objectives primary health care phc physicians foremost confront childhood adolescent obesity objective evaluate phc physicians perspectives managing overweight obesity children adolescents methods phc services eight public hospitals riyadh participated self administered tool maintaining anonymity evaluated facilitators barriers managing overweight obese children adolescent patients physicians always recommended weight management overweight obese patient past year involving patient parents others classified positive appropriate practice results respondents appropriate practices lack patient motivation parental involvement major barriers physicians appropriate practices differed perspectives less appropriate practices attending continued education forums referring patients sub specialty clinical knowledge convinced interventions low concern precipitating eating disorders comfortable examining obese patients considered patient readiness weight change conclusion efforts needed equip phc physicians managing overweight obesity saudi children adolescents
background acute cerebellitis inflammatory process commonly involving cerebellar hemispheres bilateral cerebellar hemisphere involvement common finding acute hemicerebellitis childhood extremely rare unilateral presentation cerebellitis mimicking tumor etiology unknown although inflammatory post infectious origin presumed clinical outcome generally good self limited evolution clinical improvement regression pathological findings serial mri help differentiate acute hemicerebellitis neoplastic process case presentation present case hemicerebellitis year old girl presenting severe headache projectile vomiting mixed neuropsychiatric manifestation mri brain revealed unilateral cerebellar involvement
background agriculture among hazardous industries united states methods longitudinal study injury among migrant hispanic farm workers residing six northern california migrant family housing centers mhcs harvest season conducted participants completed initial interviewer administered work health questionnaire beginning harvest season addressing preceding year three periodic follow surveys results adult farm workers participation completed initial questionnaire completed final follow survey agricultural injuries incidence full time equivalent employees ftes fte increased risk agricultural injury occurred among women paid piece rate sprains strains common followed lacerations conclusions agricultural injury experience cohort comparable agricultural workers settings increased risk among women paid piece rate suggests study potential policy changes regarding payment regimens heterogeneity injury population presents major prevention challenge view high frequency strain sprain injuries ergonomic interventions deserve study wiley liss inc
background although ageing workers face specific health safety concerns conflicting evidence exists regarding effects age workplace injury rates workers compensation claims aims examine injury workers compensation claim rates age injury type aluminium smelter year period methods routinely collected data workplace injuries workers compensation claims retrieved period results study included total workers experienced work injuries submitted claims employees aged proportion doubled injury claim rates age groups change significantly period workers younger years age highest injury rates differences significant injuries sprains strains claim rates significantly different across age groups conclusions findings provide evidence support notion older workers sustain injuries likely claim compensation injuries findings demonstrate workplace older workers able maintain ability work safely contrasts finding younger workers highest injury claim rates adapting needs ageing workforce employers lose sight need nurture strong culture working safely among youngest workers
background aim decreased adherence mediterranean diet may related rise chronic non communicable diseases childhood onward aim systematic review summarize available literature regarding adherence children adolescents focusing specifically association adherence demographic anthropometric variables body composition lifestyle diet adequacy methods results search scientific literature carried pubmed scopus clinical trials results google scholar british library inside studies published last years fifty eight papers finally included according following criteria adherence evaluated quantifying score index age years sample size participants observational intervention studies regarding general population kidmed index widely used scoring system adherence widely varied within mediterranean countries children adolescents also large differences among various european countries data available non mediterranean countries eligible studies showed adherence directly associated physical activity possibly diet adequacy inversely sedentary behavior results gender age socioeconomic status weight status consistent conclusions validation indexes terms reproducibility consistency needed time prospective cohort intervention studies may better elucidate relationships adherence behavioral health outcomes italian society diabetology italian society study atherosclerosis italian society human nutrition department clinical medicine surgery federico university published elsevier rights reserved
background aims bowel damage crohn disease defined presence intestinal strictures fistulas abscesses early disease may represent window opportunity timely intervention evaluated disease activity severity lemann index magnetic resonance index activity maria score prognostic value early methods consecutive patients diagnosed two referral centres assessed magnetic resonance imaging computerized tomography prospectively included disease activity bowel damage early correlation maria score value cross sectional imaging findings predicting disease progression assessed statistical analyses employed time event methods results included consecutive patients median time diagnosis baseline imaging years median follow time years diagnosis patients bowel damage multivariable analysis bowel damage independent prognostic factors intestinal surgery hazards ratio respectively related hospitalization patient follow respectively disease activity expressed maria score predict disease course correlation maria score weak rho conclusion four ten patients bowel damage time first imaging study presence bowel damage maria score early associated worse outcome increased risks surgery hospitalization
background aims internet gaming disorder igd imposes potential public health threat worldwide gaming motives potentially salient factors igd research chinese gaming motives scarce study empirically evaluated psychometric properties chinese version motives online gaming questionnaire mogq first inventory measures seven different gaming motives applicable type online games also investigated associations various gaming motives igd symptoms among chinese gamers methods three hundred eighty three chinese adult online gamers mean age years voluntarily completed online anonymous survey december results confirmatory factor analysis results supported factor model general factor subsuming mogq items general motivation seven uncorrelated domain specific factors escape coping fantasy skill development recreation competition social high internal consistencies overall scale subscales observed criterion related validity chinese version also supported positive correlations mogq scale scores psychological need satisfaction time spent gaming furthermore found high general motivation coupled high escape motive low skill development motive associated igd symptoms reported chinese participants discussion conclusions findings demonstrated utility mogq measuring gaming motives chinese online gamers recommend consideration total score subscale scores future studies
background aims limited evidence available relationship apoptosis cardiovascular disease population based samples examined whether blood soluble fas sfas associated mortality cardiovascular diseases methods nested case control study large prospective cohort japan collaborative cohort jacc study total subjects years age provided serum samples followed years measured sfas levels among cases controls matched sex age area residence year serum storage conditional logistic regression models used calculate odds ratio mortality stroke stroke types according quartiles increment sfas levels results follow identified men women deaths total stroke comprising subarachnoid hemorrhages intra parenchymal hemorrhages ischemic strokes coronary heart diseases adjustment cardiovascular risk factors multivariable odds ratio subarachnoid hemorrhage associated increment sfas men women association found blood sfas levels risk intraparenchymal hemorrhage ischemic stroke coronary heart disease conclusions higher blood sfas levels associated higher mortality subarachnoid hemorrhage suggesting potential role apoptosis factors development prognosis subarachnoid hemorrhage published elsevier ireland ltd
background aims aim study investigate hong kong nationals ability recognize different mental disorders examine whether may relationship mental health literacy mhl tendency describe explain symptoms mental disorders physical terms methods total participants took part study vignettes depict post traumatic stress disorder depression obsessive compulsive disorder ocd dependent personality disorder schizotypal personality disorder generalized anxiety disorder agoraphobia bipolar disorder social phobia panic disorder narcissistic personality disorder schizophrenia antisocial personality disorder results overall ocd best identified personality disorders worst significant negative correlation found participants mhl rate offering physical rather psychological explanation mental disorders better recognized others ocd depression however majority disorders poorly recognized labelled rest correct response rates lower half mental disorders correct response rates lower conclusion accordance many studies area study found asian participants poor recognizing mental disorders probably due fact mental illnesses kinds remain taboo topic
background aims impact tobacco use cessation atherogenesis remains unclear aimed study association tobacco use prior cessation presence extent severity atherosclerosis coronary computed tomographic angiography cta methods examined consecutive symptomatic patients without known coronary artery disease cad referred cta stratified smoking status never current within days former days cta plaque severity none stenosis composition non calcified ncp partially calcified pcp calcified plaque segment involvement score sis visually graded multivariate analysis performed adjusting cad risk factors cholesterol lowering medication use results median age patients years iqr male never smokers current smokers former smokers median quit duration years iqr smoking exposure former versus current smokers iqr iqr pack years respectively compared never smokers current smokers demonstrated increased odds ratio plaque types adjusted ncp pcp non obstructive cad aor obstructive cad aor sis aor compared current smoking prior smoking cessation years associated decreased odds ratio ncp aor aor obstructive cad aor conclusions current smoking independently associated presence extent coronary plaque higher risk non obstructive obstructive cad compared never smoking prior smoking cessation correlated improvements cta identified plaque measures published elsevier ireland ltd
background aims determine relationship risk exercise addiction rea health status amateur endurance cyclists methods men women cyclists inactive subjects men women examined rea exercise addiction inventory training status volume frequency experience performance socioeconomic status quality life qol quality sleep pittsburgh sleep quality index anxiety depression hospital anxiety depression scale cardiometabolic risk body mass index physical activity international physical activity questionnaire physical condition international fitness scale adherence mediterranean diet mediterranean diet adherence screener alcohol tobacco consumption results total cyclists showed evidence rea showed low rea rea occurred independent age sex training socioeconomic status regardless rea cyclists displayed better physical qol lower cardiometabolic risk inactive subjects cyclists rea displayed worse values mental qol quality sleep anxiety cyclists low rea rea group better values mental qol anxiety similar values quality sleep inactive subjects differences mental qol rea low rea groups significantly greater women addiction sex interaction analyzed variables conclusion results suggest increased prevalence rea limits benefits amateur endurance cycling mental health quality sleep
background aimsalcohol use major contributor injuries mortality burden disease review updates knowledge risk relations dimensions alcohol use health outcomes used global national comparative risk assessments cras methodssystematic review reviews meta analyses alcohol consumption health outcomes attributable alcohol use dimensions exposure volume alcohol use blood alcohol concentration patterns drinking particular heavy drinking occasions studied liver cirrhosis quality alcohol additionally considered outcomes mortality morbidity cause death disease injury categories based international classification diseases icd codes used global cras harm others resultsin total reviews meta analyses identified alcohol use found linked causally many disease injury categories icd three digit categories fully attributable alcohol partially attributable disease categories showed monotonic relationships volume alcohol use alcohol consumed higher risk disease death exceptions ischaemic diseases diabetes curvilinear relationships beneficial effects light moderate drinking people without heavy irregular drinking occasions biological pathways suggest impact heavy drinking occasions additional diseases however lack medical epidemiological studies measuring dimension alcohol use precluded depth analysis injuries except suicide blood alcohol concentration important dimension alcohol use alcohol use caused marked harm others yet researched sufficiently conclusionsresearch since confirms importance alcohol use risk factor disease injuries health outcomes one dimension use needs considered epidemiological studies include measurement heavy drinking occasions line biological knowledge
background aimsgambling disorder characterized poor regulation negative emotions impulsive behaviours study aimed compare gambling disorder patients gdps healthy controls hcs self report brain activation measures emotion regulation establish relationship negative emotion driven impulsivity designtwo cross sectional case control studies including gdps hcs setting participantsgdps hcs recruited specialized gambling clinics andalusia spain following patient treatment community respectively study included gdps hcs males age standard deviation respectively study included gdps hcs males age respectively measurementsin study compared groups suppression appraisal emotion regulation strategies emotion regulation questionnaire erq study compared gdps hcs brain activation associated regulation negative emotions cognitive appraisal task measured functional magnetic resonance imaging fmri studies correlated measures emotion regulation mood related impulsivity indicated negative urgency upps impulsive behaviour scale findingsgdps relative hcs showed higher levels emotional suppression means difference hcs gdps confidence interval higher activation premotor cortex middle frontal gyrus negative emotion regulation fmri task cluster size voxels negative urgency correlated positively emotional suppression one tailed middle frontal gyrus activation negative emotion regulation gdps conclusionsgambling disorder associated greater use emotional suppression stronger pre motor cortex middle frontal gyrus activation regulating negative emotions compared healthy controls emotional suppression use middle frontal gyrus activation negative emotion regulation linked negative emotion driven impulsivity disorder
background aimsprevious studies mostly focused diagnostic accuracy transbronchoscopic lung biopsy tblb diagnosis interstitial lung diseases ilds aimed explore clinical usefulness tblb results diagnostic procedure undefined ilds methodsthe retrospective analysis included patients undergoing tblb diagnosis undefined ilds january december clinically useful tblb defined lead specific histopathological diagnosis consistent working diagnosis based existing clinical radiological data resultsa total patients included study tblb failed obtain lung parenchyma cases tblb considered clinically helpful procedures including cases provided definitive histopathological diagnoses cases consistent working diagnoses among cases clinically useful tblbs majority diagnosed pulmonary alveolar proteinosis pap cases connective tissue disease related ilds ctd ilds idiopathic pulmonary fibrosis ipf although tblb could provide definitive histopathological diagnoses cases diagnosed pap cases ipf ipf diagnoses ctd ilds ctd ild diagnoses could identified tblbs conclusionthe clinical usefulness tblb conjunction thorough clinical radiological data diagnosis ilds may varied depending different subtypes use histopathological analysis type biopsy employed therefore considered case case basis
background aimssubstance use disorders associated commonly comorbid physical illness fewer data dental disease conditions spite high rates dry mouth xerostomia well associated indirect life style effects poverty lack access care compared oral health people substance use disorders suds non using controls methodthis systematic search studies last years oral health people reporting suds used medline psycinfo ovid google scholar embase article bibliographies results compared general population oral health assessed terms dental caries periodontal disease using following standardized measures mean number decayed missing filled teeth dmft surfaces dmfs probing pocket depth non carious tooth loss assessed clinically resultswe identified studies sufficient data meta analysis comprising patients controls people sud significantly higher mean scores dmft mean difference confidence interval dmfs mean difference decayed teeth fewer restorations indicating reduced access dental care patients sud also exhibited greater tooth loss non carious tooth loss destructive periodontal disease compared controls conclusionpatients substance use disorders greater severe dental caries periodontal disease general population less likely received dental care
background objective according world health organization epilepsy affects approximately million people electroencephalogram eeg records neurological activity brain used identify epilepsy visual inspection eeg signals time consuming process may lead human error feature extraction classification two main steps required build automated epilepsy detection framework feature extraction reduces dimensions input signal retaining informative features classifier assigns proper class label extracted feature vector aim present effective feature extraction techniques automated epileptic eeg signal classification methods study two effective feature extraction techniques local neighbor descriptive pattern lndp one dimensional local gradient pattern lgp introduced classify epileptic eeg signals classification epileptic seizure non seizure signals performed using different machine learning classifiers benchmark epilepsy eeg dataset provided university bonn used research classification performance evaluated using fold cross validation classifiers used nearest neighbor support vector machine svm decision tree artificial neural network ann experiments repeated times results lndp lgp feature extraction techniques ann classifier achieved average classification accuracy respectively classification normal epileptic eeg signals eight different experimental cases tested classification results better existing methods conclusions study suggests lndp lgp could effective feature extraction techniques classification epileptic eeg signals elsevier ltd rights reserved
background objective light funding constraints sub saharan africa ssa value research performed must increased objective study describe epidemiology published randomized controlled trials rcts performed ssa methods searched pubmed cochrane library african index medicus identify reports rcts performed ssa published january march systematically recorded country affiliation corresponding author funding source overall burden disease assessed disability adjusted life years sexes ages percentages two locations ssa high income countries hics results rcts conducted sub saharan africa another region rcts trial centers exclusively located ssa corresponding author affiliation ssa trials institutions hics almost half trials funding source nonprofit trials hics overall rcts targeted diseases high burden ssa trials targeted five diseases highest burden ssa mainly malaria hiv aids lower respiratory tract infection diarrheal diseases preterm birth complications nevertheless among diseases health related conditions highest burden ssa assessed rct conclusions published rcts performed ssa mainly funded led hic institutions although investigations concerned diseases highly prevalent ssa elsevier inc rights reserved
background objective males females use methamphetamine differ sociodemographics diagnoses comorbidities brain activity objective study investigate sex differences characteristics use dependence patients thai substance treatment center methods demographic use diagnostic data users obtained using semi structured assessment drug dependence alcoholism thai version categorical comparisons males females made chi square test factors significantly differentiating men women respect dependence identified logistic regression analysis controlling demographic diagnostic use variables results males admitted residential drug treatment use earlier age onset use years dependence years females likely males dependent chi experiencemawithdrawal chi withdrawal related hypersomnia chi fatigue chi psychomotor retardation chi similarly females heavier largest daily amount chi frequent chi greater lifetime episodes use chi males controlling variables logistic regression female remained significant factor influencing occurrence dependence odds ratio confidence interval shared associated factors comorbidities dependence sexes included nicotine dependence males females greater lifetime episodes use males females frequent use males females comorbid antisocial personality disorder predicted dependence males conclusions current study highlights common nicotine dependence severity use sex specific differences use dependence characteristics comorbidities including sex respect dependence thai treatment cohort
background objective medical image processing contribute detection diagnosis human body anomalies represents important tool assist minimizing degree uncertainty diagnosis providing specialists additional source diagnostic information strabismus anomaly affects approximately population strabismus modifies vision eyes properly align influencing binocular vision depth perception additionally results aesthetic problems reversed age however use low cost computational resources assist diagnosis treatment strabismus yet widely available work presents computational methodology automatically diagnose strabismus digital videos featuring cover test using workstation computer process videos methods method proposed validated patients exotropia consists eight steps acquisition detection region surrounding eyes identification location pupil identification location limbus eye movement tracking detection occluder identification evidence presence strabismus diagnosis results detect presence strabismus proposed method achieved specificity value sensitivity value accuracy diagnosis patients extropia procedure recognized diagnose strabismus accuracy value acknowledging measures lower average error deviation measure delta conclusions demonstrated feasibility using computational resources based image processing techniques achieve success diagnosing strabismus using cover test despite promising results proposed method must validated greater volume video including types strabismus elsevier rights reserved
background objective isolated cardiomyocyte preparation amenable several experimental approaches suitable myocardial tissue allowed gain important information pathophysiology cardiac muscle thus development techniques functional studies preparation important goal present study develop computer program extract contraction traces generated cyclic cell shortening cardiomyocyte video image files methods canny algorithm widely used computer vision implemented cell edge recognition continuous tracking changes cardiomyocyte length could monitored program applied demonstrate effect classical inotropic maneuvers contraction parameters well assess development spontaneous activity response defibrillator like electrical shocks rat isolated cardiomyocytes results method resulted successful monitoring variations cell length electrically triggered post shock spontaneous contractions rate significantly related shock strength conclusions proposed approach might useful analysis contractile activity isolated muscle cells allows detection even typically low amplitude noisy spontaneous contractile events additionally experimental data suggest rate spontaneous contraction could used index shock induced electrical membrane damage
background objective medical research council dyspnoea score mrcds simple objective scale assess dyspnoea main complaint patients chronic interstitial lung disease ild sought investigate whether mrcds predictor outcome patients chronic ild methods one hundred fifteen patients idiopathic pulmonary fibrosis ipf non ipf ild retrospectively studied baseline time diagnosis mrcds month changes considered endpoints month clinical progression defined either absolute reduction forced vital capacity fvc percent predicted decline min walk distance hospitalization respiratory causes lung transplantation ltx assessment death month survival results end observation period subjects experienced clinical progression including deaths ltx patients ipf longitudinal increase mrcds predicted clinical progression significantly area curve auc sensitivity specificity baseline mrcds strong predictor mortality auc sensitivity specificity patients non ipf ild longitudinal increases mrcds baseline values predictive clinical progression auc sensitivity specificity mortality auc sensitivity specificity considering whole population mrcds increase fvc decline independent predictors mortality conclusion longitudinal increases mrcds predict poor outcome chronic ild good accuracy baseline mrcds remains strong predictor mortality ipf mrcds included global assessment clinical course chronic ild
background objective volume healthcare data including different variable text types sounds images increasing day day therefore storage processing data necessary challenging issue generally relational databases used storing health data able handle massive diverse nature methods study aimed presenting model based nosql databases storage healthcare data despite different types nosql databases document based dbs selected survey nature health data presented model implemented cloud environment accessing distribution properties data distributed database applying shard property results efficiency model evaluated comparison previous data model relational database considering query time data preparation flexibility extensibility parameters results showed presented model approximately performed sql server read query acted efficiently sql server write query also performance presented model better sql server case flexibility data preparation extensibility conclusions based observations proposed model effective relational databases handling health data elsevier ireland ltd rights reserved
background objectiveidiopathic pulmonary fibrosis ipf specific form chronic progressive fibrosing interstitial pneumonia nintedanib significantly reduced annual rate decline forced vital capacity fvc compared placebo patients ipf two replicate trials inpulsis examined efficacy safety nintedanib japanese patients methodswe conducted pre specified subgroup analyses annual rate decline fvc time first acute exacerbation change baseline george respiratory questionnaire sgrq total score safety using pooled data inpulsis trials japanese patients resultsin overall population patients nintedanib placebo groups respectively japanese results japanese patients consistent overall population japanese patients adjusted annual rate decline fvc year nintedanib group year placebo group difference year hazard ratio time first adjusted mean change baseline sgrq total score week nintedanib group placebo group difference diarrhoea liver related adverse events common events nintedanib group reversible following dose reduction drug interruption symptomatic therapy conclusionthe present results indicate efficacy safety nintedanib japanese patients comparable overall population pre specified subgroup analysis two phase iii randomized placebo controlled trials inpulsis involving sites countries including japanese sites revealed efficacy safety profiles nintedanib japanese patients idiopathic pulmonary fibrosis similar observed overall population trials
background objectivein two replicate randomized phase iii inpulsis trials patients idiopathic pulmonary fibrosis ipf nintedanib significantly reduced annual rate decline forced vital capacity fvc compared placebo key secondary endpoints time first investigator reported acute exacerbation change baseline george respiratory questionnaire total score weeks assessed effect nintedanib asian patients methodspre specified subgroup analyses effect nintedanib primary key secondary endpoints asian versus white patients undertaken based pooled data two inpulsis trials safety data analyzed descriptively resultsof treated patients asian nintedanib placebo white nintedanib placebo asian patients nintedanib versus placebo difference adjusted annual rate decline fvc year treatment effect nintedanib annual rate decline fvc asian white patients similar treatment subgroup interaction consistent overall population significant treatment subgroup interaction observed key secondary endpoints asian white patients asian patients common adverse event nintedanib group diarrhoea patients placebo conclusionin pre specified subgroup analyses asian versus white patients ipf inpulsis trials race influence effect nintedanib disease progression
background objectiveperiodontal diseases major public health concern leading tooth loss also shown associated several chronic systemic diseases smoking major risk factor development numerous systemic diseases well periodontitis clear smokers significantly enhanced risk developing periodontitis leading tooth loss population varies regarding susceptibility disease associated smoking investigation focused identifying differences four broad sets variables consisting host response molecules periodontal clinical parameters iii antibody responses periodontal pathogens oral commensal bacteria variables interest population smokers without periodontitis material methodsbayesian network structured learning bnsl techniques used investigate potential associations cross talk four broad sets variables resultsbnsl revealed two broad communities markedly different topology populations smokers without periodontitis confidence edges resulting network also showed marked variations within periodontitis nonperiodontitis groups conclusionthe results presented validated known associations discovered new ones minimal precedence may warrant investigation novel hypothesis generation cross talk clinical variables antibody profiles bacteria especially pronounced case periodontitis mediated antibody response profile porphyromonas gingivalis
background objectives women need different forms contraception lifetime developed world access different methods developing countries options available paper focuses four used methods intrauterine devices implants emergency contraception female condoms examines reasons low uptake strategies used adoption challenges sustaining efforts two countries laos zambia methods country documentation reports international partners reviewed questionnaires sent interviews carried ministry officials senior providers local representatives international organisations international non governmental organisations results laos family planning programme relatively young challenges include ensuring sustainability services supplies improving quality iec dispel misconceptions surrounding contraception developing novel distribution systems reach rural populations zambia much older programme lost ground face competing health priorities challenges include strengthening supply chain management coordinating multiple groups providers ensuring sustainability services rural areas conclusions contrast offered laos zambia illustrates importance regular evaluation identify priority areas improving contraceptive delivery
background objectives adolescence related increases anxiety risk taking may originate variability intolerance uncertainty rendering study importance therefore studied psychometric properties intolerance uncertainty scale short version ius including associations trait anxiety risk taking among adolescents methods sample dutch adolescents diverse educational levels equal distribution boys girls classically tested obtain indices self reported trait anxiety need risk taking questionnaires administrated obtain index risk taking behavior adolescents performed risk taking task results multi group confirmatory factor analyses revealed ius consists prospective inhibitory subscale partially measurement invariant across sex cronbach alphas item total correlations revealed ius subscales reasonable good internal consistency correlational analyses support convergent validity higher ius scores related respectively higher lower levels self reported trait anxiety need risk taking however found relationship ius scores risk taking behavior operationalized performance risk taking task limitations community instead clinical sample included also measured paper pencil version ius instead computerized version conclusions ius good psychometric properties may central measure assess enables explain adolescence related increase anxiety risk taking elsevier ltd rights reserved
background objectives alexithymia multidimensional personality construct including components difficulties identifying feelings dif difficulties describing feelings ddf externally oriented thinking eot different features alexithymia thought reflect specific deficits cognitive processing regulation emotions aim present study examine first time patterns deployment attention function alexithymia components healthy persons using eye tracking technology assumed eot linked avoidance negative images methods healthy adults viewed freely pictures consisting anxiety related depression related positive neutral images gaze behavior registered alexithymia assessed item toronto alexithymia scale measures anxiety depression visual perceptual intelligence also administered results main effect emotion condition dwell times observed viewing time lowest neutral images longer depression related happy images longest anxiety related images gender eot significant effects dwell times eot correlated negatively dwell time depression related anxiety related images correlations dwell times depression trait anxiety intelligence dif ddf limitations alexithymia assessed exclusively self report conclusions results show eot dif ddf influences attention deployment simultaneously presented emotional pictures eot may reduce attention allocation dysphoric information attentional characteristic eot individuals might mood protecting effects also detrimental impacts social relationships coping competencies elsevier ltd rights reserved
background objectives cognitive models obsessive compulsive disorder ocd highlight role cognitive biases development disorder one biases inflated sense responsibility associated higher anger scores latent aggression self report scales especially patients compulsive checking validity self report assessment however compromised inaccuracy social desirability low metacognitive awareness traits behaviors patients aim present study extend research latent aggression individuals ocd using indirect implicit measure aggression methods fifty eight patients ocd healthy controls assessed aggressiveness implicit association test iat reaction time task assesses strength associations concept aggressiveness compared others results contrary expectation ocd patients checking symptoms showed peaceful implicit self concept healthy controls result corroborated negative correlations checking symptoms implicit aggressiveness ocd sample limitations self report measures aggression anger included study conclusions comparison previous research using self report measures study indicates implicit aspects aggression indeed differ controlled aspects patients checking compulsions future research necessary better understand role aggressiveness ocd derive implications therapy elsevier ltd rights reserved
background objectives mortality substance misuse constantly changing pattern notable rising trends certain regions country particular camden county new jersey historically struggled problem inclusion camden city high poverty rate high availability illicit drugs broader regional impact economic recession analysis substance misuse related death population might facilitate understanding contributory factors development maintenance addiction resulting mortality methods mortality population data obtained public sources subjects demographic information substance profile found death investigated regression trend analysis results across study period overwhelming majority subjects white adult males opiate derivatives highest offending agent occurring deaths followed stimulants benzodiazepines furthermore subjects found substances death significant trends found mortality rates camden county significantly higher rates drug mortality rest new jersey study period conclusions scientific significance study highlights opiate epidemic major player camden county also notes significant mortality contributions stimulant drugs benzodiazepines setting polysubstance use elicited time death imperative focus basic needs particularly housing outpatient long term programs rather inpatient rehabilitation especially population high poverty rate
background objectives patients social anxiety disorder suffer pronounced fears social situations gaze perception crucial situations examined factors influence range gaze directions mutual gaze experienced cone gaze methods social stimulus modified changing number people heads present emotional expression faces participants completed psychophysical task adjust eyes virtual head gaze edge range mutual eye contact experienced results number heads affected width gaze cone heads wider gaze cone emotional expression virtual head consistent effect width gaze cone however affect emotional state participants angry expressions produced highest arousal values highest valence emerged happy faces lowest valence angry faces conclusion results suggest widening gaze cone social anxiety disorder primarily mediated altered emotional reactivity implications gaze assessment gaze training therapeutic contexts discussed limitations due interindividual variability enlarged gaze cones necessarily indicative social anxiety disorder merely constitute correlate group level elsevier ltd rights reserved
background objectives seeds sophora alopecuroides var alopecuroides may benefit treatment opioid dependence therefore plant alkaloid composition toxicity effects morphine withdrawal studied methods alkaloid composition determined analysis mice made dependent morphine injected times day days withdrawal jumping diarrhea induced administration naloxone injection morphine day ethanol extract alkaloid fraction morphine saline injected min naloxone drugs injected subcutaneously groups consisting mice assess toxicity different doses ethanol aqueous extracts dissolved normal saline gavaged groups consisting mice afterward numbers dead animals within gavage counted calculated results matrine cytisine sophoridine methyl cytisine sophocarpine sophoramine major alkaloids doses total extract alkaloid fraction morphine decreased jumping diarrhea significantly compared saline ethanol aqueous extracts respectively conclusion plant inhibited opioid withdrawal efficacy comparable morphine alkaloids may involved effect ethanol aqueous extracts moderately slightly orally toxic respectively
background objectivethe copd assessment test cat reported potential utility measuring health status idiopathic pulmonary fibrosis ipf although cat developed assessment copd patients fully evaluated exclusively ipf study designed evaluate validity cat ipf methodsthe clinical data consecutive subjects newly diagnosed ipf completed pulmonary function tests partial pressure oxygen arterial blood pao rest min walk test mwt cat george respiratory questionnaire sgrq modified medical research council mmrc dyspnoea grade hospital anxiety depression scale hads analysed assessed validity cat comparison sgrq resultsthe present subjects showed mild moderate restrictive impairment spirometry mean cat score total sgrq respectively concurrent validity cat score comparison sgrq total score significant internal consistency cronbach repeatability months intraclass correlation coefficient cat also significant single regression analysis showed cat significant construct validity multiple regression analysis mmrc pao rest minimum spo mwt anxiety hads independent predictors cat conclusionsthe cat valid health status measurement ipf patients multiple regression analysis showed cat significantly correlated dyspnoea severity oxygenation impairment anxiety validity copd assessment test cat evaluated exclusively idiopathic pulmonary fibrosis ipf patients comparison george respiratory questionnaire sgrq cat significant correlation sgrq independently predicted dyspnoea severity oxygenation impairment anxiety
background purpose pancreatic fistula pancreatoduodenectomy uncommon reports describe stricture pancreatogastrointestinalstomy investigated clinical influence anastomotic stricture caused pancreatogastrointestinalstomy methods subjects prospective cohort study patients underwent pylorus preserving reviewed relationships pancreatic duct dilatation remnant pancreas several risk factors also compared pancreatic duct dilatation pancreatic atrophy analyzed nutrient parameters first postoperative year results patients preoperative pancreatic duct diameter less significantly dilated postoperative pancreatic duct diameter average atrophy rate remnant pancreas lowest atrophy rate seen patients without pre postoperative pancreatic duct dilation normal pancreas pancreatic duct dilatation developed postoperatively high atrophy rate moreover patients without pre postoperative pancreatic dilatation gained body weight conclusions study shows significant correlation pancreatic atrophy rate weight loss atrophy remnant pancreas caused anastomotic stricture influences exocrine function patients anastomotic method must improved prevent pancreatic duct dilatation allow early diagnosis management stenotic lesions
background purpose improved biomarkers needed facilitate clinical decision making surrogate endpoints clinical trials multiple sclerosis assessed whether neurodegenerative neuroinflammatory markers cerebrospinal fluid csf initial sampling could predict disease activity years follow patients clinically isolated syndrome cis relapsing remitting methods using multiplex bead array enzyme linked immunosorbent assay cxcl cxcl cxcl cxcl ccl ccl neurofilament light chain nfl neurofilament heavy chain glial fibrillary acidic protein chitinase like matrix metalloproteinase osteopontin analysed csf patients cis relapsing remitting healthy controls disease activity relapses magnetic resonance imaging activity disability worsening patients recorded years follow prospective longitudinal cohort study results logistic regression analysis model nfl csf baseline emerged best predictive marker correctly classifying patients showed evidence disease activity years follow patients overall proportion patients correctly classified combining nfl either neurofilament heavy chain osteopontin resulted overall correctly classified patients whereas combining nfl chemokine improve results conclusions study demonstrates potential prognostic value nfl baseline csf cis relapsing remitting supports use predictive biomarker disease activity
background purpose significant effects clinical neuroradiological disease activity reported patients relapsing remitting multiple sclerosis treated delayed release dimethyl fumarate dmf phase iii define confirm trials conducted post hoc analysis integrated data define confirm evaluate effect dmf achieving evidence disease activity neda patients relapsing remitting multiple sclerosis methods analysis included patients randomized dmf twice daily placebo glatiramer acetate confirm years time event method used estimate percentage patients achieving neda clinical neda relapses week confirmed disability progression analysed intention treat itt population neuroradiological new newly enlarging hyperintense lesions gadolinium enhancing lesions overall neda clinical neuroradiological neda analysed magnetic resonance imaging mri cohort results itt mri populations comprised patients respectively percentage patients clinical neda itt population neuroradiological neda mri cohort higher dmf versus placebo years clinical neda relative reduction hazard ratio confidence interval neuroradiological neda relative reduction percentage patients achieving overall neda mri cohort also higher dmf versus placebo years relative risk reduction conclusions significantly higher percentage patients treated dmf achieved neda status years compared placebo
background aspirin use effective prevention cardiovascular disease however patients equally responsive aspirin oxidative stress reflected isoprostane iso prostaglandin alpha isopgf alpha potential mechanism failure aspirin adequately inhibit cyclooxygenase objective examine relation cause mortality concentrations urinary dehydro thromboxane dhtxb isopgf alpha patients stable coronary artery disease cad methods data analysis prospective study patients categorized four groups based median values dhtxb isopgf alpha results patients included analysis median range age years median range values dhtxb isopgf alpha respectively total patients died median follow days reference group cox proportional hazards survival analysis patients values dhtxb isopgf alpha corresponding medians adjusting age sex patients values dhtxb greater median significantly higher risk mortality compared reference group high dhtxb low isopgf alpha adj hazard ratio confidence interval high dhtxb isopgf alpha adj hazard ratio confidence interval findings similar adjusted comorbidities cancer kidney function ejection fraction conclusion found dhtxb appears better prognostic marker mortality compared isopgf alpha suggesting aspirin resistance stronger independent determinant death cad patients treated aspirin coron artery dis copyright wolters kluwer health inc rights reserved
background association antiphospholipid syndrome systemic lupus erythematosus sle valvular heart disease vhd well reported relatively studies carried establish linkage vhd sle aimed investigate link vhd sle evaluate association diverse factors vhd among patients large scale population based study materials methods used databases largest state mandated health service organization israel sle patients included well age sex matched controls creating cross sectional population based study medical records subjects analysed documented vhd presence antiphospholipid antibodies apls logistic regression model carried evaluate diverse factors including sle apls independent risk factors vhd results valvular heart disease found frequent among sle group compared controls aortic stenosis respectively aortic insufficiency respectively mitral stenosis respectively mitral insufficiency respectively male sex hypertension apls sle found significant independent risk factors vhd conclusion vhd prevalent among sle patients compared controls sle apls independent risk factor vhd respectively physicians must aware significant association routine echocardiography considered sle patients regardless apl status
background childhood obesity become global epidemic recent studies reported risk thyroid dysfunction due obesity therefore study intends compare relative frequency thyroid function disorders obese overweight children non obese children materials methods case control study birjand iran done children adolescents years overweight obesity case group non obese subjects control group body mass index bmi thyroid stimulating hormone tsh free triiodothyronine free thyroxine measured analyzed using spss software version results tsh level obese children significantly levels less non obese subjects control group case group patients showed hypothyroidism disorder difference significant control group significant relationship tsh moreover case group significant relationship tsh also conclusion overweight obesity children adolescents effect increase tsh decrease long term studies larger sample size suggested
background children adolescents involving antisocial behaviour one strongest predictors development antisocial personality disorder adults rapid cognitive physical development occurs stage life even though knowing antisocial behaviour highly problematic society due disruption societal norms prevalence behaviour community known aim estimate prevalence antisocial behaviour among children adolescent age groups materials methods total participants sexes children adolescents age years educational institution shimoga district parents advised come school get interviewed using child behaviour check list cbcl years order assess antisocial behaviour among children adolescent age groups along self constructed questionnaires assess personal bio data factors responsible behaviours considered statistically significant results overall prevalence antisocial behaviour age groups males higher prevalence antisocial behaviour compared female counterparts prevalent antisocial behaviour vehicle related nuisances followed criminal damages differences causal factors among genders significant conclusion identifying factors associated antisocial behaviour among children adolescents critical developing effective preventive strategies early intervention minimise risk progression serious criminal behaviour later life study concluded much antisocial behaviour exists among children adolescents school students behaviours found significantly associated respondents gender parents economic status parenting style
background chronic exposure environmental triggers house dust mite hdm drives helper cell mediated asthma recent evidence shown cell interaction particular germinal centre reactions follicular helper tfh cells required development eosinophilic airway inflammation hdm driven models containing sensitization challenge phase whether cell interactions essential pulmonary eosinophilic inflammation following chronic allergen provocation remains unknown aims study investigated importance cell interaction development eosinophilic airway inflammation pulmonary remodelling chronic hdm driven asthma model methods exposed cbl cdl mice hdm three times week five consecutive weeks results chronic hdm exposure induced pronounced eosinophilic allergic airway inflammation broncho alveolar lavage fluid balf lung tissue associated formation immunologically active inducible bronchus associated lymphoid tissue ibalt lungs absence cells lack cdl signalling hamper eosinophilic inflammation airways although number tfh cells substantially reduced lungs importantly type innate lymphoid cell ilc numbers balf lung affected absence cells cell interaction furthermore eosinophilic airway inflammation sufficient induce pulmonary remodelling airway hyperresponsiveness conclusion clinical relevance findings conclude cell interaction required robust tfh cell induction essential eosinophilic airway inflammation chronic hdm driven asthma model
background cognitive differences including deficits self awareness common high functioning individuals autism spectrum disorder asd represent fruitful target intervention current project presents preliminary research undertaken development metacognitive training mct intervention designed increase knowledge personal strengths challenges adolescents asd method two groups adolescents asd completed mct well measures assess satisfaction adverse effects visual inspection thematic analysis used interpret data results overall participants parents rated mct favourably youth enjoyed interactive activities whereas parents appreciated opportunity socialising psychoeducation systematic changes quantitative measures adverse effects self esteem depression conclusion although results suggest investigation mct may warranted certain modifications mct protocol research methodology needed
background context half perforations reported usage cervical pedicle screws cps lateral perforations endangering vertebral artery medial cortical pedicle screw mcps technique partial drilling medial cortex shifts trajectory pedicle screws medially decreasing lateral perforations purpose evaluate decrease lateral perforations cps use mcps technique relation medial angulation study design setting retrospective analysis technical report mcps technique safety patient sample total patients operated december may insertion pedicle screws included study outcome measures axial reconstructed computed tomography scan images inserted screws evaluated placement perforations transverse plane angulations using surgimap software surgimap spine intl nemaris llc angulations screws analyzed type level placement unpaired test analysis variance test methods total patients operated december may insertion pedicle screws included study males females thirty seven patients cervical trauma cervical spondylotic myelopathy two tumors two ankylosing spondylitis average age years range years screws inserted using mcps technique patients underwent postoperative scans optima slice scanner healthcare chalfont giles buckinghamshire axial reconstructed images along axis inserted screws evaluated placement perforations screws evaluated transverse plane angulations using surgimap software angulations screw analyzed type level placement unpaired test analysis variance test funds received authors purpose present study results total screws assessed postoperative scans two hundred fifty six found placed within pedicle screws found perforations forty screws grade medial perforations screws grade lateral perforations screws grade medial perforations screws grade lateral perforations average angulation nonperforated screws degrees degrees degrees laterally perforated screws degrees degrees degrees medially perforated screws degrees degrees degrees statistical analysis series range screw angles degrees degrees laterally perforated screw series degrees degrees medially perforated screw series degrees degrees conclusions mcps technique represents shift concept placement cps cancellous core medial cortex avoiding screw deflection laterally thick proximal medial cortex present study shows lateral perforations consistently avoided medial angulation degrees primary concern use pedicle screws lower cervical spine mcps technique reduces lateral perforations lesser insertion angle technically desirable elsevier inc rights reserved
background controversy exists impact acute atrial fibrillation termination prolongation atrial fibrillation cycle length afcl ablation long term procedural outcome objective purpose study analyze influence termination afcl prolongation freedom patients star substrate trigger ablation reduction atrial fibrillation trial part trial methods acute changes afcl termination collected index procedure star trial compared recurrence months recurrence assessed ecg holter months weekly transtelephonic ecg monitoring months results terminated pulmonary vein isolation pvi arm pvi complex electrogram arm pvi linear ablation arm freedom differ among groups freedom significantly higher patients presented laboratory sinus rhythm compared without termination patients termination intermediate outcome significantly different terminate termination univariable predictor success multivariable analysis presence early strongest predictor success hazard ratio prolongation afcl predictive month freedom conclusion acute termination prolongation afcl consistently predict month freedom presence early ablation strongest predictor better outcome
background current data lacking incidence correlates prognosis associated incident myocardial infarction patients stable coronary artery disease cad furthermore contribution late stent thrombosis vlst events remains poorly understood objectives study aimed analyze residual risk together relevant associated factors related mortality stable cad outpatients methods multicenter coronor suivi une cohorte patients coronariens stables region nord pas calais study enrolled unselected outpatients stable cad coronary revascularization year previously five year follow achieved patients results identified linear risk incident annually segment elevation constituting one third cases current smoking low density lipoprotein cholesterol multivessel cad diabetes glycosylated hemoglobin persistent angina associated increased risk prior bypass surgery associated decreased risk used time dependent variable incident associated increased risk death hazard ratio among patients prior stent implantation vlst causal cases presented often segment elevation versus related stented site adjusted mortality times higher patients vlst related stented site conclusions stable cad outpatients incident occurs stable rate annually related vlst one fifth cases associated increased mortality risk especially vlst multivessel cad residual uncontrolled risk factors strongly associated american college cardiology foundation
background daclatasvir asunaprevir combination therapy shown high virological response chronic genotype hepatitis virus hcv infected patients however safety efficacy therapy older patients unknown methods one hundred seventy patients younger years patients aged years older genotype hcv infection treated weeks daclatasvir plus asunaprevir pretreatment drug resistance associated variants nsa nsa determined invader assay virological response adverse events according age analyzed results sustained virological response svr rate older patients similar younger patients respectively multivariate regression analysis prior simeprevir treatment odds ratio absence identified significant independent predictor svr svr rate patients pretreatment resistance associated variants ravs low population frequency less similar patients detectable ravs frequency adverse events similar younger older patients elderly patients years older completed weeks treatment achieved svr conclusion older patients virological response tolerance daclatasvir plus asunaprevir therapy similar younger patients even though ravs detected virological response similar patients detectable ravs may still expected patients ravs long population frequency low
background elbasvir ebr combination grazoprevir gzr demonstrated efficacy patients hepatitis virus hcv infections trials primarily conducted usa europe investigated safety efficacy ebr combination gzr japanese patients chronic hcv infection without cirrhosis methods study conducted two parts part noncirrhotic patients randomized receive ebr combination gzr daily weeks part noncirrhotic patients randomized receive immediate deferred treatment ebr gzr determined part weeks cirrhotic patients received open label immediate treatment primary efficacy end point rate sustained virologic response weeks completion study treatment result part patients randomized receive ebr combination gzr dose svr rates gzr dose gzr dose tolerability similar arms part noncirrhotic patients randomized receive immediate treatment deferred treatment cirrhotic patients enrolled svr rates immediate treatment noncirrhotic cirrhotic patients respectively safety generally similar immediate deferred treatment conclusion treatment ebr combination gzr weeks effective well tolerated japanese patients chronic hcv infection
background equal access mainstream healthcare services people intellectual disabilities still requires attention although recent studies suggest health professionals hold positive attitudes towards people stigmatising attitudes may influence efforts serve people community healthcare practice stimulate inclusion mainstream healthcare services systematic review focussed barriers attitudes mainstream health professionals towards people method five electronic databases systematically searched references full text articles checked studies published english language january january social psychological triad cognitive affective behavioural dimensions stigmatising attitudes used structure discuss results results literature search generated records studies passed exclusion criteria studies mostly cross sectional moderate quality respect stigma lack familiarity knowledge people found considered stable condition personal control moreover mainstream health professionals either low high expectations capabilities people professionals reported stress lack confidence fear anxiety tendency treat people differently lack supporting autonomy conclusions stigmatising attitudes towards people appeared present among mainstream health professionals might affect ongoing challenges regarding inclusion mainstream healthcare services facilitate inclusion mainstream healthcare services recommended include contact collaboration experts experience education programs health professionals future research progress beyond descriptive accounts stigma towards exploring relationships cognitive affective behavioural dimensions pointers intervention finally inclusion would benefit understanding equal treatment means reasonable adjustments instead undifferentiated treatment
background fall injuries constitute significant problem commercial fishing injuries hitherto subject closer analysis methods distribution characteristics occupational injuries among commercial fishermen described using data emergency department period recorded special registration system results consistent investigations injuries falls made injuries cause contusions fractures sprains strains injuries lower extremities injuries chest proportion fall injuries different age groups shaped constitutes around men years years age around ages frequent types injury mechanisms falls slips getting caught contact objects persons foreign body cuts conclusions use proportionate data gave detailed description injuries falls slips showing important areas prevention avoid possible misclassification fall injuries future studies recommended include extra specific variable whether falling slipping preceded crash phase injury wiley liss inc
background femoroacetabular impingement fai describes painful abnormal bony contact femoral neck acetabulum left untreated contributes early osteoarthritis hip despite flat learning curve long operation times hip arthroscopy used increasingly often recent years surgery femoroace tabular impingement mini open technique mot offers possible alternative addresses abnormal morphological prominence allows minimally invasive clearance hip motion still lack information influence greater degree soft tissue intrusion inherent mini open approach therefore decided evaluate medium term outcome mini open technique compare results arthroscopic technique reported literature patients material und methods patients hips women men underwent mini open surgical treatment fai followed average months evaluation focused pre postoperative pain intensity nrs numeric rating scale clinical functional outcomes rom range motion hos hip outcome score mhhs modified harris hip score changes athletic behaviour satisfaction patients radiological analysis angle anterior head neck offset hno head neck offset ratio ossification grade performed using preoperative immediate postoperative well follow radiographs finally results compared reported arthroscopic technique literature results average pain level decreased confirmed amean postoperative pain free period months months still almost pain free time final followup mhhs increased seemto experience insufficient gains surgery surgeons reluctant apply technique circumstances
background geriatric falls leading causes hospital trauma admissions injury related deaths medication use crucial element among extrinsic risk factors falls reduce fall risk prevalence adverse drug reactions potentially inappropriate medication pim lists widely used objective aim investigate possible predictors geriatric falls annualized year long period well evaluate medication use nursing home residents setting nursing home residents recruited institution szeged hungary method retrospective epidemiological study performed patient data analysed first months residency chi squared test fisher test applied compare categorical variables student test compare continuous variables groups binary logistic regression analysis carried determine association falls variables found significant univariate analysis microsoft excel ibm spss statistics version programs used data analysis main outcome measure falls affected age gender number chronic medications polypharmacy pim meds results total nursing home residents included women men fallers annual fall prevalence rate non fallers gender predisposing factor falls prevalence males females fallers older mean years non fallers years significant risk factor falls number chronic medications higher male fallers non fallers polypharmacy taking four chronic medications significant risk factor falls taking pantoprazole vinpocetine trimetazidine significant risk factor falls conclusion older age polypharmacy independent use pantoprazole vinpocetine trimetazidine found major risk factors falls real life epidemiological studies necessary confirm role particular active agents help professionals prescribe evaluate review geriatric medication use
background headache common patients moyanoya angiopathy mma usually underestimated management well characterized methods validated self administered headache screening questionnaire telephone interview used order investigate headache characteristics frequency pain intensity large cohort german patients mma results thirty seven patients suffered headache past year headache intensity rated verbal rating scale seventeen patients reported migraine like headache patients reported tension type like headache patients combination majority patients migraine like headache described migrainous aura headache frequency intensity improved significantly revascularization surgery however nine patients developed new onset headache postoperatively conclusion headache common mma often migraine like phenotype tension type like headache also found patients new finding reported
background health care providers fill central role prevention child abuse neglect unintentional childhood injury health communication interventions hold promise promoting attitudes behaviours among parents increase positive parenting practices may linked decreased rates intentional unintentional childhood injuries manuscript describes development rise ambulatory clinic based childhood injury prevention programme provides tailored injury prevention print materials parents children ages methods fifteen semi structured key informant interviews conducted clinic healthcare providers staff develop communication strategies materials caregivers cognitive response testing conducted caregivers priority population assess materials interviews recorded transcribed analyzed using thematic coding methods results formative research revealed health care providers caregivers responsive messages materials health care providers reported abuse neglect particularly relevant patients noted several benefits implementing rise programme health care setting caregivers generally found messages reducing risks injuries well graphics displayed rise programme helpful conclusions addressing common determinants intentional unintentional childhood injury customized print materials may useful component comprehensive prevention efforts address childhood injury risk greater impact providers parents responded favourably communication strategy
background champion cardiomems heart sensor allows monitoring pressure improve outcomes new york heart association nyha functional class iii heart failure patients trial heart failure hospitalization hfh rates lower patients managed guidance implantable pulmonary artery pressure sensor compared usual care objectives study examined effectiveness ambulatory hemodynamic monitoring reducing hfh outside clinical trial setting methods conducted retrospective cohort study using medicare claims data patients undergoing pulmonary artery pressure sensor implantation june december rates hfh pre defined periods implantation compared using andersen gill extension cox proportional hazards model accounting competing risk death ventricular assist device implantation cardiac transplantation comprehensive heart failure related costs compared periods results among patients receiving implants hfhs months compared hfhs deaths ventricular assist device implantations transplants months implantation hazard ratio confidence interval lower rate hfh associated month comprehensive cost reduction per patient iqr robust analyses restricted month survivors similar reductions hfh costs noted subset patients complete data available months implantation conclusions clinical trials use ambulatory hemodynamic monitoring clinical practice associated lower hfh comprehensive costs benefits sustained year support real world effectiveness approach management american college cardiology foundation
background ischaemic colitis common form intestinal ischaemia wide spectrum severity possible risk death objective purpose study evaluate predictive factors hospital short term mortality cohort patients methods retrospective analysis cases diagnosed single tertiary centre assessment factors time diagnosis associated hospital day mortality results patients included women died follow median months patients died hospitalization days deaths total multivariate analysis need vasopressor support odds ratio confidence interval intermediate intensive care unit icu admission atrial fibrillation independently significantly associated hospital mortality using coefficients estimated logistic model calculated scoring model predict occurrence hospital mortality presence three risk factors predicted probability death area receiver operating characteristic curve auroc days presence chronic kidney disease male sex also independently associated mortality conclusions deaths ischaemic colitis occur first days admission sharing similar risk factors assessment presence atrial fibrillation need vasopressor support hospitalization intermediate intensive care unit provides useful tool estimate hospital mortality establish management patients admitted ischaemic colitis
background kallmann syndrome rare genetic condition characterized congenital early onset hypogonadotropic hypogonadism anosmia hyposmia male subjects frequently affected present absent delayed puberty low testosterone levels higher risk osteoporosis therefore maintain normal levels sex steroids prevent bone loss male needs life long hormonal replacement therapy hrt aims objective study assess bone involvement subjects currently treated hrt methods retrospective study analyzed data medical records patients treated hrt either gonadotropins testosterone preparations including clinical history biochemical parameters following outcome measures bone mineral density bmd lumbar spine femoral neck total body less head tblh vertebral fracture assessment vfa dual energy ray absorptiometry dxa results clinical instrumental data patients evaluated mean age years mean body mass index bmi four patients bmd score expected range age five patients vertebral deformities observed vfa duration hrt related bone health parameters bmd measured sites higher patients receiving adequate hrt years compared patients treated less months deficient vitamin status found cases prevalent patients shorter hrt discussion conclusion early starting adequate duration hrt related bone health parameters patients congenital hypogonadotropic hypogonadism due restoring vitamin sufficiency might also advisable condition
background migraine prevention guidelines recommend oral prophylactic medications patients frequent headache study examined oral migraine preventive medication ompm treatment patterns evaluating medication persistence switching initiation patients chronic migraine methods retrospective claims analysis truven health marketscan databases evaluated patients years old diagnosed initiated ompm january september treatment persistence measured six months follow time discontinuation assessed ompm compared using cox regression models among discontinued proportion switched ompms within days initiated treatment days associated persistence rates also assessed results total patients met inclusion exclusion criteria persistence initial ompm six months months based kaplan meier curves sharp decline patients discontinuing observed days approximately half discontinued days similar trends time discontinuation seen following second third ompm amitriptyline gabapentin nortriptyline significantly higher likelihood non persistence compared topiramate among patients discontinued switched another prophylactic initiated therapy within one year among patients switched persistence among initiated patients persistence months conclusions persistence ompms poor six months declines months switching ompms common results indicate persistence worsens patients cycle various ompms
background formal systematic review meta analysis performed summarize risk factors delirium hip surgery aims present study aimed quantitatively comprehensively conclude risk factors delirium hip surgery elderly patients methods search applied cnki embase medline cochrane central database august studies assessing risk factors delirium hip surgery elderly patients without language restriction reviewed qualities included studies assessed using newcastle ottawa scale data pooled meta analysis completed results total studies selected altogether included patients hip fracture one thousand ninety cases delirium occurred surgery suggesting accumulated incidence results meta analyses showed elderly patients preoperative cognitive impairment odds ratio confidence interval advanced age standardized mean difference living institution heart failure total hip arthroplasty multiple comorbidities morphine usage likely sustain delirium hip surgery females less likely develop delirium hip surgery conclusions related prophylaxis strategies implemented elderly patients involved mentioned risk factors prevent delirium hip surgery
background noise cluster analyses potentially mask true underlying patterns tease patterns uniquely certain populations bayesian semi parametric clustering method presented infers adjusts background noise method built upon mixture dirichlet process point mass function simulations demonstrate effectiveness proposed method method applied analyze longitudinal data set allergic sensitization asthma status elsevier rights reserved
background counter medicines must supplied appropriate user friendly medicine information satisfactorily support consumer self management safe use product labels written medicine information leaflets highly accessible counter medicine information sources consumers factors comprehensibility design underpin usefulness counter labels leaflets examined better inform future optimisation strategies aim review undertake depth exploration studies evaluated design comprehensibility counter labels written medicine information leaflets methods database searches performed using medline embase international pharmaceutical abstracts pubmed studies exploring counter medicine label leaflet comprehensibility design identified additional author reference list searches performed identify studies met inclusion criteria key terms results total studies included review explored otc medicine information design comprehensibility via researcher evaluation alone consumers researcher determined counter written medicine information leaflet readability highlighted suboptimal readability studies evaluating counter leaflet performance using gold standard method user testing consumers variable counter label comprehensibility identified consumer studies ranging satisfactory understanding considerable misunderstanding review findings indicate consumer outcomes influenced information design implementation good design principles generally improved counter label leaflet performance significant diversity existed study design aspects sampling frames sample sizes tools used evaluate counter medicine information hindered ability adequately compare various study aspects findings conclusion wide spectrum consumer understanding counter medicine labels evident literature limited studies examining counter written medicine information leaflet comprehensibility consumers application good information design principles counter labels leaflets contribute improved performance well designed consumer studies needed ascertain optimise overthe counter label leaflet performance
background paramedics respond emergency scenes often uncontrolled settings without aware potential risks makes paramedicine one dangerous occupations one dangers risk contracting infectious diseases research area predominantly focused compliance use protective equipment attitudes perceptions paramedics infectious disease policy exposure rates blood body fluids purpose scoping review determine known impact infectious disease health paramedics methods using arskey malley methodological framework scoping review undertaken allows broad search available evidence results literature search identified eight articles review reported paramedic exposure trends lack reported blood borne infections contracted hepatitis hepatitis human immunodeficiency virus hiv instances severe acute respiratory syndrome sars infections higher prevalence methicillin resistant staphylococcus aureus mrsa nasal infections amongst paramedics conclusions exposure infectious diseases decreasing yet remains significant decrease attributed prevention strategies however paramedic knowledge attitudes well uncontrolled environment paramedics work barrier contraction infectious diseases generally low exceptions mrsa colonization influenza sars paramedics greater risk acquiring infectious diseases compared general public effect health paramedics well reported
background percutaneous patent foramen ovale pfo closure therapeutic option prevent recurrent cerebral ischaemia patients cryptogenic stroke transient cerebral ischaemia tia apparent lack benefit seen previous randomised trials part reflected inclusion patients alternate mechanisms stroke role formal neurology involvement accurately delineating likely aetiology stroke tia crucial appropriate identification patients device closure furthermore benefits device closure may accrue time long term follow essential define role device closure management presumed cryptogenic stroke methods retrospectively reviewed experience percutaneous pfo device closure since subjects underwent pfo closure john hunter lake macquarie private hospitals included study patients referred device closure following cryptogenic stroke tia first undergone formal neurology review appropriate imaging exclusion paroxysmal atrial arrhythmia patients history transient ischaemic attack tia frequently referred specialised clinic aimed identify patients conditions referable cerebral ischaemia investigations initiated specialist clinic elucidate underlying aetiology outcome data derived hunter new england area local health district cardiac stroke outcomes unit addition review medical record cardiac stroke outcomes unit prospectively identified patients presenting stroke tia atrial fibrillation results one hundred twelve consecutive patients undergoing percutaneous patent foramen ovale closure identified average age years patients male cryptogenic stroke transient cerebral ischaemia common indications pfo closure amplatzer device used cases early residual shunting visible seven patients however follow agitated saline study two patients residual shunt annual risk recurrent stroke tia conclusions percutaneous patent foramen ovale closure performed safely effectively patients paradoxical embolism selected patients following appropriate multidisciplinary specialist pre procedural assessment excellent long term results low incidence recurrent events may achieved
background spinal cord stimulation scs form therapy used treat certain types chronic pain involves electrical generator delivers pulses targeted spinal cord area leads implanted laminectomy percutaneously source power supplied implanted battery external radio frequency transmitter exact mechanism action scs poorly understood objectives assess efficacy effectiveness spinal cord stimulation relieving certain kinds pain well complications adverse effects procedure search methods searched medline embase september cochrane central register controlled trials central issue textbooks reference lists retrieved articles also contacted experts field pain main manufacturer stimulators selection criteria included trials control group either randomized controlled trials rcts non randomized controlled clinical trials ccts assessed spinal cord stimulation chronic pain data collection analysis two independent reviewers selected studies assessed study quality extracted data one assessors methodological quality blinded authors dates journals data analysed using qualitative methods best evidence synthesis main results two rcts patients total met inclusion criteria one judged high quality score jadad scale low quality score jadad scale one trial included patients complex regional pain syndrome type reflex sympathetic dystrophy patients failed back surgery syndrome follow periods varied months studies reported scs effective however meta analysis undertaken small number patients heterogeneity study population authors conclusions although limited evidence favour scs failed back surgery syndrome complex regional pain syndrome type trials needed confirm whether scs effective treatment certain types chronic pain addition needs debate trial designs provide best evidence assessing type intervention
background systemic lupus erythematosus sle patients often treated glucocorticoids place risk bone loss objectives objectives article determine prevalence low bone mineral density bmd factors associated low bmd prevalence symptomatic fragility fractures inception patients toronto lupus cohort tlc methods prospectively collected data tlc inception patients first bmd analyzed pre menopausal women males years bmd expected range age defined score post menopausal women males age older osteoporosis defined score low bone mass score patients bmds defined abnormal score score remainder normal descriptive analysis logistic regression employed results patients inception patients bmd results mean age years female overall prevalence abnormal bmd pre menopausal women prevalence bmd expected range post menopausal women prevalence osteoporosis low bmd respectively age cumulative dose glucocorticoids statistically significantly associated abnormal bmd multivariate analysis inception patients tlc experienced symptomatic fragility fractures peripheral vertebral course disease conclusion prevalence low bmd high sle patients associated older age higher cumulative glucocorticoid dose
background clinical utility serum igg measurement diagnosis allergy food induced hypersensitivity largely discredited recent studies however shown specific igg inhibit ige mediated allergies may play role allergen specific desensitization accurate reference intervals igg specific allergens widely established needed better interpretation serum antibody concentrations study established igg reference intervals common food allergens venoms molds design specific igg concentrations determined employing automated fluorescent enzyme immunoassay serum samples normal adults males females age range mean results lower reference interval limit allergens tested mcg median upper reference interval value allergens mcg tuna lowest upper interval limit mcg mold setomelanomma rostrate demonstrating highest upper interval limit mcg conclusions considerable variation observed among upper reference interval limits emphasizes need establishment allergen specific ranges igg newly established ranges useful aid clinicians interpretation laboratory serum igg results
background promotion healthy eating physical activity within school settings important component population based strategies prevent obesity however adolescents may vulnerable weight related messages rapid development life stage often leads preoccupation body size shape objective study examines secular trends secondary school curricula topics relevant prevention unhealthy weight control behaviors describes crosssectional associations weight related curricula content students use weight control behaviors assesses whether implementation school based obesity prevention policies practices longitudinally related students weight control behaviors design minnesota school health profiles minnesota student survey grades data used along national center education statistics data examine secular trends cross sectional associations schools longitudinal associations schools main outcome measures students self reported height weight along past year use healthy exercise unhealthy fasting extreme use laxatives weight control behaviors statistical analyses performed descriptive statistics generalized estimating equations generalized linear regression models accounting school level demographics results observable pattern years mean number curricula topics addressing unhealthy weight control behaviors despite increase prevalence curricula addressing acceptance body size differences including three fewer weight control topics specifically including topic eating disorders curricula related lower school level percent students using extreme weight control behaviors contrast overall measure implementing school based obesity prevention policies practices prohibited advertising unrelated use unhealthy extreme behaviors conclusions results suggest obesity prevention policies practices unintended consequences student weight control behaviors support importance school based health education part efforts prevent unhealthy behaviors
background triarchic model psychopathy characterizes disorder terms three distinguishable phenotypic facets disinhibition meanness boldness present study sought inform current debates regarding role boldness definition psychopathy clarify boundaries psychopathy antisocial personality disorder aspd method study evaluated degree facets triarchic model represented widely used clinical inventory psychopathy psychopathy checklist revised pcl comparison aspd defined dsm criteria adult male offenders two distinct correctional settings investigated ensure replicability findings across samples exhibiting high base rates psychopathy antisocial behavior results found evidence convergent discriminant validity three triarchic facets predicting symptomatic components psychopathy assessed pcl additionally crucially vis vis current debates field found boldness contributed incrementally disinhibition meanness prediction pcl psychopathy particular interpersonal style component aspd conclusions three distinct facets triarchic model psychopathy represented clearly distinctly pcl boldness interpersonal facet dsm defined aspd findings suggest boldness central diagnostic conceptions psychopathy distinguishes psychopathy prevalent diagnosis aspd
background thromboembolism prevention central atrial fibrillation management randomized controlled trials rcts primarily focused stroke prevention detailed analyses extracranial thromboembolic events particularly patients low dose nonvitamin antagonist oral anticoagulants noacs scarce objective purpose study assess efficacy noacs prevention extracranial arterial venous thromboembolism methods searched pubmed central cinahl april phase iii rcts noacs patients information regarding systemic embolism pulmonary embolism deep vein thrombosis dvt retrieved compared risk ratio confidence interval fixed effects model network additional rcts involving antiplatelet agents constructed surface cumulative ranking curve sucra treatment calculated assessing best treatment network meta analysis results among patients rcts relative warfarin standard dose noacs associated lower risk similar risks dvt respectively compared warfarin risks dvt low dose noacs similar network meta analyses standard dose noacs associated largest sucra prevention conclusion patients standard dose noacs efficacious treatment preventing whereas dose regimens noacs reasonable alternatives warfarin preventing venous thromboembolism
background thyroid disorders known involve organ systems body skin exception present study aimed study various cutaneous manifestations see cutaneous manifestations thyroid disorders know various dermatologic associations thyroid disorders materials methods prospective observational study conducted period months department dvl tertiary care centre patients thyroid abnormality cutaneous manifestations included study detailed clinical examination done findings recorded results thyroid disorders common females common age group affected hypothyroidism years hyperthyroidism yrs weight gain dry skin commonest symptoms among hypothyroid patients heat intolerance increased sweating commonest among hyperthyroid patients xerosis dry rough coarse skin among hypothyroid patients warm soft velvety skin among hyperthyroid commonest findings urticaria common autoimmune association noted among hypothyroid patients conclusion study could concluded better understanding complex interaction skin thyroid may help diagnose underlying thyroid abnormality also monitor response cutaneous features treatment
background characterize work related injuries illnesses minors methods analyzed washington state workers compensation claims results claims among adolescents age years accepted year period including three occupational fatalities amputations fractures injuries occurred among year olds claims frequent restaurants food stores service industry retail wholesale trade agriculture washington state census data used denominator calculating injury rates adolescents adults crude injury rate year olds employed time census similar seen among adults per workers despite minors work fewer hours per year rate among boys almost twice seen among girls per workers highest rates per workers public administration construction agriculture restaurants using census data working anytime course year adjusted number hours worked injury rate year olds full time equivalents compared full time equivalents adults injuries lacerations sprains strains contusions burns conclusions public health policy injury prevention strategies working adolescents developed implemented wiley liss inc
background total hip arthroplasty tha frequently performed despite low complication rates revisions play important clinical economical role aim study identify comorbid diseases patients undergoing primary tha potential influence survival hip replacements patients material methods total patients included retrospective study revisions reviewed took place hospital within one year primary implantation tha comorbid diseases detected administrative data using elixhauser definition includes thirty diseases cox regression model fisher exact test used examine correlations comorbidities risk revision results patients required operation within first year surgery presence one analysed comorbidities associated greater risk revision deficiency anemia obesity drug abuse alcohol abuse fluid electrolyte disorders peripheral vascular disorders associated increased risk revision comparisons conclusion total number comorbidities specific comorbid diseases independently associated increased risk operation within first year total hip arthroplasty information could helpful pre post operative risk adjustment patient selection
background true essential thrombocythemia may carry one known driver mutations jak mpl calr none triple negative neg cases patients mutational status seems delineate clinical manifestations materials methods report data patients diagnosed strictly according criteria full molecular diagnosis including following patients jakvf calr type calr type mpl neg thrombotic risk assessed means ipset thrombosis score ipset results calr neg patients lower haemoglobin levels leucocyte count jak patients calr patients type particular higher mean platelet counts extreme thrombocytosis often groups based ipset stratification neg calr mutated patients belonged frequently low risk group significant favourable thrombosis free survival rate jak mutation conclusion findings indicate three different molecular markers significant impact clinical course true giving rise different phenotypes disease
background child abuse neglect risk factor development psychiatric disorders untreated disorders sustain adulthood objectives study compares rates psychiatric disorders mental health care utilization victims methods three regions germany children adolescents aged non abusive caregiver assessed child history mental health mental health care utilization via semi structured interviews results approximately two thirds participants present state lifetime suffered psychiatric disorder classifiable icd posttraumatic stress disorder conduct disorders attention hyperactivity disorders frequently diagnosed merely using mental health care time assessment conclusions provision mental health care victims insufficient improve access appropriate services vulnerable clientele cooperation psychiatrists psychotherapists child welfare system essential implementation dissemination evidence based diagnostic methods treatments must advanced
background contact allergy rubber additives common particularly patients occupational dermatitis objectives descriptively analyse compare patch test reactions patients patch tested baseline series additional rubber series used department methods patch test data members european surveillance system contact allergies essca network www essca org also contributed data rubber series patch test results retrospectively analysed results among patients patch tested eligible patch tested baseline series special rubber series positive reaction one baseline screening rubber allergens compared patients often carba mix positive reaction allergens additional rubber series positive reaction conclusions additional testing dedicated rubber series containing break single ingredients mixes baseline series additional rubber allergens warranted patients suspected contact allergy rubber avoid false negative results
background cystic fibrosis chronic catabolic disease often requiring hospitalization acute episodes worsening pulmonary exacerbations limited data suggest vitamin may beneficial clinical affects impact vitamin systemic metabolism setting unknown objective used high resolution metabolomics hrm assess impact baseline vitamin status high dose vitamin administration systemic metabolism adults acute pulmonary exacerbation design twenty five hospitalized adults enrolled randomized trial high dose vitamin vitamin bolus versus placebo age matched healthy subjects served reference group baseline comparisons plasma analyzed liquid chromatography ultra high resolution mass spectrometry using recent hrm bioinformatics metabolic pathway enrichment methods examined associations baseline vitamin status sufficient deficient per serum hydroxyvitamin concentrations day response vitamin supplementation results several amino acids lipid metabolites differed healthy control subjects indicative overall catabolic state subjects metabolites differed baseline vitamin status enriched within metabolic pathways including fatty acid amino acid carbohydrate metabolism total metabolites showed enrichment metabolic pathways predominantly representing amino acid pathways differed vitamin placebo treated subjects time placebo group several tricarboxylic acid cycle intermediates increased several amino acid related metabolites decreased contrast little change metabolites occurred vitamin treatment conclusions numerous metabolic pathways detected hrm varied association vitamin status high dose vitamin supplementation adults experiencing pulmonary exacerbation overall pilot data suggest anti catabolic effect high dose vitamin clinical setting elsevier inc rights reserved
background false positive test results children tested food allergies may lead inappropriate dietary restrictions objective aim study report experience year old boy presented multiple food allergies however passed food challenges review experience regarding management children high specific food iges high total ige methods medical records children food challenges reviewed median age subjects months history adverse clinical reaction food specific ige greater decision point elevated total serum ige level underwent challenges offending food results subjects successfully exposed suspected foods continued tolerate foods well conclusion finding suggests much lower clinical risk previously defined specific ige decision points children high levels total ige
background healthcare workers hcws risk developing occupational skin disease osd objectives ascertain causes osd australian hcws tertiary referral clinic methods retrospective review performed patients assessed occupational dermatology clinic melbourne results hcws assessed clinic period years diagnosed osd common diagnosis irritant contact dermatitis icd followed allergic contact dermatitis acd natural rubber latex allergy also relatively frequent major substances causing acd rubber glove chemicals thiuram mix tetraethylthiuram disulfide preservatives formaldehyde formaldehyde releasers isothiazolinones excipients hand cleansers hard avoid weak allergens antiseptics acd caused commercial hand cleansers occurred frequently acd caused alcohol based hand rubs abhrs occupational icd mostly caused water wet work hand cleansers environmental irritants heat sweating conclusions understanding causes osd hcws important order develop strategies prevention suggest skin care advice incorporated hand hygiene education use abhrs encouraged weak allergens skin cleansers substituted accelerator free gloves recommended hcws osd
background patients bipolar disorder frequently exhibit impulsive behaviors independent mood state trait impulsivity increasingly recognized crucial biomarker study aimed investigate structural correlates trait impulsivity measured using barratt impulsiveness scale bis healthy controls hcs patients method recruited patients diagnosed years age sex matched hcs years participants underwent structural magnetic resonance imaging clinical evaluations bis scores evaluated automated surface based method freesurfer used measure cortical thickness generate thickness maps participant brain wise regression analysis association cortical thickness bis scores performed separately groups using general linear model results patients obtained significantly higher bis scores hcs hcs higher bis scores associated thinner cortex left inferior middle medial frontal cortices contrast patients higher bis scores associated thicker cortex right insula patients showed thinner cortex hcs four structures conclusions findings indicate left prefrontal cortex plays cardinal role trait impulsivity healthy individuals patients different structural correlate trait impulsivity right insula however use various psychotropics patients may limit interpretation findings
background rheumatoid arthritis chronic auto inflammatory disorder joints present study aimed identify key genes better understanding underlying mechanisms methods integrated analysis expression profiling conducted identify differentially expressed genes degs moreover functional annotation protein protein interaction ppi network transcription factor regulatory network construction applied exploring potential biological roles degs addition expression level identified candidate degs preliminarily detected peripheral blood cells patients gse dataset quantitative real time polymerase chain reaction qrt pcr conducted validate expression levels identified degs results total degs including regulated genes identified synovial tissues patients compared healthy controls degs significantly enriched axon guidance rna transport mapk signaling pathway rbfox lck serbp hub proteins ppi network target gene network rbfox pouf wipf pfkfb high connectivity tfs expression status candidate degs detected gse expression levels mata nsa significantly regulated regulated tendency peripheral blood cells patients compared healthy individuals qrt pcr results mata nsa compatible bioinformatics analyses discussion study might provide valuable information exploring pathogenesis mechanism identifying potential biomarkers diagnosis
background sensory processing deficits appear crucial clinical expression symptoms schizophrenia visual cortex displays dysconnectivity aberrant spontaneous activity patients persistent symptoms cognitive deficits paper examine visual cortex context remerging notion thalamic dysfunction schizophrenia examined specific regional longer range abnormalities sensory thalamic circuits schizophrenia whether patterns strong enough discriminate symptomatic patients controls method using publicly available resting fmri data controls schizophrenia patients derived conjunction maps regional homogeneity reho fractional amplitude low frequency fluctuations falff inform seed based granger causality analysis gca study effective connectivity patterns reho falff gca maps entered multiple kernel learning classifier determine whether patterns local effective connectivity differentiate controls patients results visual cortex shows reho falff reductions patients visuothalamic effective connectivity patients significantly reduced local connectivity reho patterns discriminated patients controls highest level accuracy conclusions inflow outflow granger causal information visual cortex thalamus affected schizophrenia occurs conjunction highly discriminatory localized dysconnectivity reduced neural activity within visual cortex may explain visual processing deficits present despite symptomatic remission schizophrenia
background sepsis associated decreased levels high density lipoprotein hdl cholesterol hdl anti inflammatory properties use apo mimetic peptides associated renal function improvement animal models sepsis however known whether decreased hdl level results impaired renal function human sepsis investigated whether low levels hdl conferred increased risk sepsis associated acute kidney injury aki long term decreased estimated glomerular filtration rate egfr sepsis methods hdl concentration measured plasma samples patients septic shock admission emergency department divided patients using median hdl cut value assessed frequency sepsis associated aki long term decreased egfr sepsis univariate multivariate analyses performed results patients low hdl significantly greater frequency kdigo sepsis associated aki decreased long term egfr compared high hdl adjusted sepsis associated aki decreased egfr sepsis lower hdl group respectively conclusion low hdl levels sepsis associated increased risk sepsis associated aki subsequent decreased egfr results suggest hdl may involved may marker kidney injury sepsis
background different patterns emotional intelligence deficits schizophrenia bipolar disorder yet well understood study compares levels among groups highlights potential impact non social cognition method fifty eight schizophrenia bipolar outpatients investigated using mayer salovey caruso emotional intelligence test msceit brief assessment cognition schizophrenia bacs analyses covariance performed adjustment bacs composite score results compared bipolar subjects schizophrenia patients showed significantly lower levels nonsocial cognition adjustment bacs composite score difference lost mediation analysis revealed differences schizophrenia bipolar patients strategic almost fully attributable mediating effect non social cognition conclusions findings suggest schizophrenia bipolar patients strongly influenced nonsocial cognitive functioning taken account interpreting msceit data comparative studies serious mental illness emphasizes importance cognitive remediation
background report translation cultural adaptation english turkish languages standard health utilities index hui questionnaire interviewer administration proxy assessment patients health status use assessing consecutive pediatric oncology patients periods subsequent recovery neutropenia procedure preparation turkish language questionnaire collaborative effort physician researchers turkey senior health utilities inc staff extensive experience development translation hui questionnaires turkish born residents canada standard hui questionnaires cover hui mark hui hui mark hui results mean improvement overall health related quality life hrql scores neutropenic non neutropenic phases clinically important according hui hui instruments single attribute utility scores showed clinically important size improvements phases hui mobility emotion hui self care significant reductions disability rates phases also detected pain hui hui rate decreases hui ambulation rate decline conclusions study results provide evidence turkish language questionnaire acceptable valid useful collecting parental assessments health status among young cancer patients turkey neutropenia associated important deficits overall hrql disabilities ambulation mobility emotion self care pain treatment plans include strategies addressing emotion pain problems improve hrql neutropenic patients pediatr blood cancer pediatr blood cancer wiley liss inc
background develop latent classes exposure traumatic experiences age years urban community sample use latent classes predict development negative behavioral outcomes adolescence young adulthood method total participants epidemiologically based randomized field trial children completed comprehensive psychiatric assessments young adults reported experiences nine traumatic experiences age years used latent class analysis create latent profiles traumatic experiences latent classes used predict psychiatric outcomes age years criminal convictions physical health problems traumatic experiences reported young adulthood results three latent classes childhood traumatic experiences supported data one class sample primarily female characterized experiences sexual assault reported significantly higher rates range psychiatric outcomes young adulthood another class primarily male characterized experiences violence exposure reported higher levels antisocial personality disorder post traumatic stress final class reported low levels childhood traumatic experiences parental psychopathology related membership sexual assault group conclusions classes childhood traumatic experiences predict specific psychiatric behavioral outcomes adolescence young adulthood long term adverse effects childhood traumas primarily concentrated victims sexual non sexual violence gender emerged key covariate classes trauma exposure outcomes
background travellers diarrhoea common problem affecting millions tourists year creating large economic burden risk factors known guidelines exist assist practitioners advising travellers prevent treat however data lacking regarding actual prescribing practices approaches used management study aims establish baseline identifies uniformities diversities practice methods online survey created using surveymonkey tool developed test respondent approaches pre travel management invitation participate survey distributed early selected australian new zealand speciality travel medicine centres electronic mailing list international society travel medicine istm descriptive statistics analyses using chi square analysis two sided fishers exact tests significance used results three hundred sixty four completed partially completed surveys collected respondents countries approach antibiotic choice management four different clinical scenarios assessed analyses focused identifying significant differences approach according region practice professional background level experience responses clinical scenarios suggest uniformity recommended treatment strategies clearly mild severe disease greater variability moderate disease conclusions practice diversity discussion preventative techniques prescribing self treatment medications especially moderate disease evidence based guidelines address competing issues patient health morbidity risk colonization resistant organisms may lead consistent antibiotic prescribing practices
background describe recruitment men testosterone trials designed determine efficacy treatment methods men eligible years average two morning total values symptoms objective evidence mobility limitation sexual dysfunction low vitality men eligible enroll least one three main trials physical function sexual function vitality results men recruited primarily mass mailings communities men contacted sites response mailings men responded screened telephone ascertain eligibility telephone screens eligible screening initial screening visits men eligible second screening visit completed men met criteria one trials level criterion exclusions randomized three trials two trials mean age years mean body mass index bmi mean standard deviation total conclusion despite telephone screening enrollment ratio met recruitment goals trial recruitment symptomatic older men low testosterone levels difficult feasible
background determined temporal trends hepatitis virus hcv incidence associated behavioral exposures people inject drugs pwid united states boston baltimore san francisco canada montreal netherlands amsterdam australia sydney melbourne methods using population based cohort data hcv negative pwid calculated overall within city hcv incidence trends hcv rates study enrollment period temporal trends exposure behaviors poisson regression models estimated trends hcv incidence calendar time survival models identified risk factors hcv incidence across cities estimated independent effects city calendar period hcv infection risk results among initially hcv negative participants followed prospectively person years observation pyo hcv incident infections resulted overall incidence per pyo confidence interval incidence highest remained elevated baltimore pyo san francisco pyo montreal pyo lowest melbourne amsterdam pyo pyo respectively moderate pyo sydney higher rates syringe equipment sharing lower prevalence opioid agonist therapy associated hcv incidence cities highest incidence risk infection dropped every year increase calendar time adjusted hazard ratio multivariable model conclusions differences prevention strategies injecting contexts may explain ongoing high hcv incidence north american cities emphasize need scale opioid agonist therapy increased coverage needle syringe programs north america
background postural headaches commonly associated spontaneous intracranial hypotension cerebrospinal fluid csf leakage spine subarachnoid pleural fistula spf rare serious type csf fistula mostly reported following traumatic causes case report case year old woman suffered postural headaches chiropractic manipulation neck reported brain spinal magnetic resonance imaging showed brain sagging dural defect overt csf leakage heavy weighted myelography revealed paravertebral fluid collections communicating pleural effusions bilateral spfs postural headaches relieved courses epidural blood patches discussions patient history severe spfs attributed rupture spinal leptomeninges vigorous chiropractic manipulation neck heavy weighted myelography could delineate route spfs csf leakages
background aim chronic migraine common debilitating disease limited treatment options aimed develop novel model chronic migraine ligating nasociliary nerve ncl administering nitroglycerin ntg exacerbate acute headache attacks materials methods exacerbation headache induced ntg subcutaneously administered male wistar rats days following unilateral ncl cutaneous cold allodynia tested using von frey filaments acetone respectively elevated plus maze epm results fos immunoreactivity tnc investigated results ntg administration significantly decreased threshold values nasociliary nerve ncn territory ipsilateral forepaw cold allodynia developed bilateral ncn territories number rate entrance open arms epm significantly decreased ncn ligated rats immunohistochemistry disclosed significantly increased fos positive neurons ipsilateral brainstem tnc compared contralateral side brain stem ipsilateral contralateral chronic ncn ligated rats exposed acute ntg conclusion presented model provides valid chronic migraine model relevant humans ntg challenge chronic ncl rats generated lateralized headache cephalic extracephalic allodynia altered cold sensitivity anxiety neuronal activation nociceptive laminae brainstem trigeminal pain nuclei
background aim gesturing plays important role social behavior social learning deficits frequent schizophrenia may contribute impaired social functioning information deficits course disease presence severity patterns impairment first episode patients missing hence aimed investigate gesturing first compared multiple episode schizophrenia patients healthy controls methods first episode patients multiple episode patients healthy controls matched age gender education gesturing assessed comprehensive test upper limb apraxia performance two domains gesturing imitation pantomime recorded video raters gesture performance blinded results patients multiple episodes severe gestural deficits almost gesture categories performance worse multiple first episode patients first episode patients demonstrated subtle deficits comparable pattern conclusions subjects multiple psychotic episodes severe deficits gesturing mild impairments found first episode patients independent age gender education negative symptoms results indicate gesturing impaired onset disease likely deteriorate course karger basel
background aims abnormal immune regulation increased intestinal permeability augmenting passage bacterial molecules activate immune cells monocytes macrophages reported irritable bowel syndrome ibs aim compare maturation phenotype monocytes macrophages ibs patients controls presence absence escherichia coli lipopolysaccharides lps vitro methods mononuclear cells isolated peripheral blood rome ibs patients controls cultured without lps hours maturation phenotype examined flow cytometry follows early cdc advanced cdc cxcr expression membrane markers reported mean fluorescence intensity mfi mann whitney test used significance set results cells cdc expression decreased without lps ibs mfi controls early cells without lps showed lower cdc expression ibs controls mfi groups showed less cdc response lps furthermore percentage intermediate cdc cxcr cells without lps higher ibs controls ibs finally fractalkine receptor cxcr expression advanced cells increased treated lps controls ibs conclusions initial phase monocyte macrophage maturation appears advanced ibs compared controls however decreased cxcr patients ibs compared controls stimulated lps suggests state immune activation ibs
background aims erythropoiesis hepatitis virus infection unclear aimed evaluate erythropoietic components chronic hepatitis chc patients methods red blood cell rbc components serum erythropoietin epo levels relationship clinical characteristics evaluated age matched sex matched healthy controls histology proven chc patients results chronic hepatitis patients significantly higher serum levels epo log miu versus log miu lower hemoglobin concentrations versus compared healthy controls among chc patients serum epo level negatively associated concentration confidence intervals rbc counts positively correlated necroinflammatory activity fibrosis liver histopathology non cirrhotic chc patients severity liver necroinflammatory activity positively correlated reticulocyte serum epo levels respectively negatively related rbc counts using stepwise multivariate linear regression analysis grade necroinflammatory activity positive whereas concentration inversely associated serum epo levels chc patients conclusions disease activity chc patients negative impact erythropoiesis compensatory higher blunted epo responses
background aims although polycystic ovary syndrome pcos common endocrinopathy pathogenesis entirely understood typically high androgen levels associated increased virilization report rare groups patients either unexpectedly high testosterone levels despite low virilization well patients low testosterone levels despite high grade virilization one possibility atypical pcos may based altered androgen receptor signaling methods patients available parents included study alterations metaphase chromosomes gtg staining length trinucleotide cag ggc repeats androgen receptor gene determined pcr entire gene sequenced analyzed results gtg banding revealed chromosomal alterations range cag ggc repeat lengths within normal range interestingly sequencing entire gene genetic mutations identified conclusion detected mutations alter protein sequence change codon usage towards less frequent codons potentially may alter protein levels androgen signaling addition postulate also causes manifestation atypical pcos may include coregulators epigenetic alterations knowledge first report combining chromosomal analysis pcos patients full sequencing human gene linking codon usage pcos
background aims autoimmune hypophysitis rare inflammatory disease pituitary gland causing varying degrees hypopituitarism sellar compression cranial mri remains best noninvasive tool diagnose although diagnosis certainty requires pituitary biopsy objective study assess utility detecting pituitary antibodies diagnosis methods year old female turner syndrome hypothyroidism ovarian failure presented acutely hypocortisolism laboratory studies revealed secondary adrenal insufficiency mri showed hypotrophic pituitary gland loss posterior pituitary bright spot establish autoimmune basis adrenal insufficiency serum analyzed double indirect immunofluorescence presence pituitary autoantibodies results patient serum contained autoantibodies recognized adrenocorticotropic hormone secreting cells suggesting adenohypophyseal cells targeted autoimmunity serum contained antibodies identified majority gonadotropin secreting cells fsh recognition prolactin tsh secreting cells found preabsorption experiments showed antigenic targets autoantibodies anterior pituitary hormones conclusion demonstration circulating pituitary antibodies expands diagnostic options adolescent positive cell specific pituitary antibodies suggested cause secondary adrenal insufficiency karger basel
background aims sensitive skin frequently reported condition western world suggested underlined impaired skin barrier aim study investigate skin barrier molecular composition subjects using confocal raman microspectroscopy crs compare non nss individuals well atopic dermatitis allergic rhinoconjunctivitis subjects frequently report methods subjects nss included stratum corneum thickness water ceramides fatty acids natural moisturizing factor nmf measured crs along transepidermal water loss capacitance ventral forearm thenar cheek sebum levels additionally measured forearm cheek results differences nss subjects found regarding thickness water nmf content yet trend towards lower ceramides fatty acids observed cheek compared subjects group showed higher ceramides fatty acid content forearm whereas differences emerged correlation macroscopic biophysical techniques crs weak yet crs confirmed well known lower content nmf water thinner subjects filaggrin mutations conclusion skin barrier impaired terms thickness water nmf ceramides fatty acid content failure biophysical techniques follow alterations molecular composition skin barrier revealed crs emphasizes strong need sensitive specific tools vivo skin barrier analysis karger basel
background purpose anti gastric parietal cell antibody gpca anti thyroglobulin antibody tga anti thyroid microsomal antibody tma yet reported patients recurrent aphthous stomatitis ras study mainly assessed frequencies presence serum gpca tga tma different types ras patients methods serum gpca tga tma levels measured ras patients different subtypes age sex matched healthy control individuals results found ras patients major typed ras patients minor typed ras patients atrophic glossitis positive ras ras patients negative ras ras patients presence gpca tga tma sera respectively ras major typed ras minor typed ras ras ras patients significantly higher frequency gpca tga tma positivity healthy control individuals tga tma positive ras patients whose serum thyroid stimulating hormone tsh levels measured tga tma positive ras patients normal lower higher serum tsh levels respectively conclusion conclude approximately one third ras patients may gpca tga tma positivity sera gpca positive patients may develop pernicious anemia autoimmune atrophic gastritis gastric carcinoma tga tma positive patients may thyroid dysfunction hyperthyroidism hypothyroidism patients referred doctors management copyright formosan medical association published elsevier taiwan llc
background purpose studies investigated feasibility using pudendal neuromodulation regulate bladder function spinal cord injured sci animals present study aimed determine effects electrical activation pudendal sensory branch improving voiding functions rats weeks spinal cord injury explore underlying neuromodulatory mechanisms methods two urodynamic measurements used assess effects electrical stimulation bladder urethral functions simultaneous recordings intravesical pressure ivp continuous isotonic transvesical infusion isotonic ivp external urethral sphincter eus electromyography eus emg simultaneous recordings transvesical pressure isovolumetric conditions isovolumetric ivp urethral perfusion pressure upp results six weeks sci rats showed voiding dysfunction indicated abnormal cystometric measurements increased volume threshold increased contraction amplitude increased residual volume decreased voided volume voiding efficiency decreased sci increased applying pudendal afferent stimulation addition pudendal stimulation significantly increased eus burst period increased difference upp high frequency oscillation hfo baselines changed time offset bladder eus activities findings suggest pudendal afferent stimulation improved prolonging micturition interval decreased urethral resistance recovered detrusor sphincter dyssynergia voiding phase conclusion study demonstrates feasibility using pudendal neuromodulation chronic sci rats results could aid developing advanced neural prosthesis restore bladder function clinical settings copyright formosan medical association published elsevier taiwan llc open access article license
background purpose treatment atopic dermatitis psoriasis requires differentiation eczematoid dermatitis determination disease severity however clinically difficult findings subjectively interpreted investigated utility vivo autofluorescence measurements diagnosis diseases determination severity materials methods thirty patients psoriasis recruited together sex age matched patients healthy skin intensity measured using ecoskin fluorescence video dermatoscope psoriasis patients non sun exposed lesional non lesional skin measured identify locations reflect characteristics also measured sites patients results associated lower psoriasis higher intensity peaking around addition skin intensity disease associated severity lesion conclusions non invasive measurement skin vivo aid diagnosis psoriasis well treatment monitoring
background purposewashing face mild cleanser generally recommended acne care occasionally general public misconception acne exacerbated cleansers furthermore concerns inducing skin irritation xerosis intensive washing recently developed new cleanser based sodium laureth carboxylate alkyl carboxylates aec soap cleans sebum well without penetrating stratum corneum methodswe designed controlled clinical trial conducted adult japanese males moderate less acne twenty subjects washed faces aec soap base cleanser twice day weeks assessment efficacy conducted prior start study end weeks resultssignificant improvement acne observed within weeks acne lesions detectable subjects week sebum secretion levels skin significantly increased forehead significantly decreased cheek correlated improvement complaints dryness irritation occurred study conclusionwashing face twice day facial cleanser based aec soap effective care moderate less grade facial acne
background gluten related disorders term encompasses different diseases induced ingestion gluten containing food incidence scientific community intensively studying aim support gastroenterologists correct nomenclature diagnostic approach gluten related disorders adulthood methods italian association hospital gastroenterologists endoscopists aigo commissioned panel experts prepare position statement clarifying nomenclature diagnosis gluten related disorders focusing gastroenterological interest member assigned task levels evidence recommendation proposed results panel identified celiac disease wheat allergy non celiac gluten sensitivity gluten related disorders gastroenterological interest celiac disease autoimmune nature wheat allergy ige mediated pathogenesis non celiac gluten sensitivity still unknown case non ige mediated allergy diagnosis start serological screening celiac disease wheat allergy case normal values response gluten free diet evaluated confirmatory blind food challenge carried conclusions gluten related disorders clinically heterogeneous patients carefully managed specific protocols applied correct differential diagnosis gastroenterological setting editrice gastroenterologica italiana published elsevier ltd rights reserved
background better understanding potential relationship mood disorders sleep quality pain headache frequency may assist clinicians determining optimal therapeutic programs aim current study analyze effects sleep quality anxiety depression potential relationships headache intensity burden headache headache frequency chronic tension type headache ctth methods one hundred ninety three individuals ctth participated headache features collected weeks headache diary hospital anxiety depression scale used assessing anxiety depression headache disability inventory evaluated burden headache pain interference determined bodily pain domain questionnaire sleep quality assessed pittsburgh sleep quality index path analyses maximum likelihood estimations conducted determine direct indirect effects depression anxiety sleep quality frequency headaches result two paths observed first depression second sleep quality mediators direct effects noted sleep quality emotional burden disease pain interference depression depression headache frequency first path showed indirect effects depression emotional burden sleep quality headache frequency first model direct effects second path depression pain interference sleep quality sleep quality headache frequency sleep quality indirectly mediated effects depression emotional burden pain interference headache frequency second model conclusions depression sleep quality anxiety mediated relationship headache frequency emotional burden disease pain interference ctth
background current focus biofilm research chemical interaction microorganisms within biofilms prerequisites research bioassay systems integrate reliable tools planning experiments robot assisted measurements rapid data processing data structures human machine readable may particularly useful results report present several simplification robotisation options assay bacteria induced biofilm formation freshwater diatom achnanthidiumminutissimum also tested several proof concept robotisation methods pipetting well measuring biofilm absorbance directly multi well plates furthermore exemplify implementation improved data processing workflow assay using konstanz information miner knime free open source data analysis environment workflow integrates experiment planning files absorbance read data towards automated processing analysis conclusions workflow lead substantial reduction measurement data processing workload still reproducing previously obtained results minutissimum biofilm assay methods scripts files designed described offering adaptable options medium throughput biofilm screenings
background diet low fermentable oligosaccharides disaccharides monosaccharides polyols fodmaps increasingly recommended patients irritable bowel syndrome ibs aimed investigate effects blinded low fodmap high fructo oligosaccharides fos diet symptoms immune activation gut microbiota composition short chain fatty acids scfas methods twenty patients diarrhea predominant mixed ibs instructed follow fodmap diet lfd throughout week study period weeks randomized double blindly assigned receive supplement either fos fodmap maltodextrin placebo next days followed week washout period crossover irritable bowel syndrome severity scoring system ibs sss used evaluate symptoms cytokines interleukin tumor necrosis factor alpha analyzed blood samples gut microbiota composition rrna scfas analyzed fecal samples key results irritable bowel syndrome symptoms consistently improved weeks lfd significantly participants reported symptom relief response placebo fos serum levels proinflammatory well levels fecal bacteria actinobacteria bifidobacterium faecalibacterium prausnitzii total scfas butyric acid decreased significantly lfd compared baseline ten days fos supplementation increased level bacteria whereas levels cytokines scfas remained unchanged conclusions inferences findings support efficacy lfd alleviating ibs symptoms show changes inflammatory cytokines microbiota profile scfas may consequences gut health
background free floating ball thrombus left atrium rare clinical condition however diagnosis condition facilitated advent development echocardiography multi detector row computed tomography mdct several cases reported case report report case year old woman recurrent giant spherical thrombi left atrium diagnosed chronic atrial fibrillation years age pacemaker implantation performed years age complete atrioventricular block mitral valve replacement performed severe mitral regurgitation years age history cerebral infarction treatment chronic heart failure despite intensive anticoagulant therapy developed ball thrombi left atrium three times six months hospitalization acute myocardial infarction treated percutaneous catheter intervention transthoracic echocardiography computed tomography revealed free floating giant spherical thrombus left atrium treated intensive anticoagulation therapy left atrial ball thrombus disappeared however two ball thrombi left atrium left atrial appendage recurred three months surgical removal thrombi closure left atrial appendage performed unfortunately ball thrombus left atrium recurred three months conclusions present case highlights difficulty treating refractory thrombi left atrium
background growing body research explored altered physical pain threshold tolerance non suicidal self injury nssi suicidal self harm evidence however inconsistent nature relationship unclear whether effect also present suicidal self harm equivocal methods keyword search three major psychological medical databases psycinfo medline web knowledge conducted yielding records following duplicate removal screening articles quality assessed included final systematic review results strong evidence increased pain tolerance nssi evidence suicidal individuals notably prospective studies review found lack substantive focus psychological correlates altered pain tolerance population several candidate explanatory mechanisms proposed within reviewed studies limitations current review narrative systematic review methods used assess pain considered heterogeneous conduct meta analysis conclusions evidence suggests elevated pain tolerance among engage nssi future prospective research determine altered pain tolerance cause consequence behaviour identification psychological correlates increased pain tolerance neglected area research could provide opportunities treatment intervention development mediating moderating pathways identified studies directly investigated candidate explanatory mechanisms draw definitive conclusions elsevier rights reserved
background high percentage sports injuries occur school sports aim study collect statements opinions sports teachers safety physical education methods cross sectional study teachers without teaching qualification exercise sports tyrolean new middle schools former secondary schools interviewed judged various statements school sports safety using point verbal rating scale results irrespective gender teachers teaching qualification stated significantly frequently participated continuing education accident prevention colleagues without qualification applies checking gymnastic sports equipment use warming beginning lesson female sports teachers allowed pupils often participate without adequate sportswear physical education male counterparts respondents knew technical faults sports halls also reported school administration half reported defects repaired completely one third partial repair reported participants estimated major risk school sports injuries due low motor skills pupils inhomogeneous groups large numbers pupils outdated sports equipment ball games conclusion since third surveyed teachers teaching qualification exercise sports group come focus regular continuing education accident prevention
background high prevalence symptoms mental disorders somd found among people living hiv aids plhiv additionally somd may impact prevalence high risk health behaviours hrb study investigates relationship somd hrb large sample vietnamese hiv positive outpatients methods cross sectional study conducted outpatients two hiv aids clinics chi minh city vietnam selected using systematic sampling technique validated scales used measure somd specifically symptoms depression anxiety alcohol use disorder aud substance use disorder sud hiv associated dementia participants completed self report questionnaire assessing hrb preceding months including unsafe sexual practices illicit drug use multivariable logistic regression models used evaluate associations somd hrb results majority participants male median age years unsafe sexual practices illicit drug use reported participants prevalences depression aud anxiety sud symptoms respectively association somd hrb either without adjusting correlates hrb except symptoms sud illicit drug use plhiv symptoms sud likely use illicit drugs adjusted odds ratio conclusions prevalence somd among hiv positive outpatients high somd associated increased hrb illicit drug use predicted symptoms sud screening plhiv symptoms sud may useful detecting people likely engaging illicit drug use reduce risk secondary disease transmission
background lifestyle characterized poor eating habits physical inactivity risk factor multiple lifestyle diseases young adults study assessed effects implementing intensive day health promotion program combining diet physical activities body composition physical fitness biochemical parameters young adults material methods randomized pilot study female undergraduate students randomly allocated intervention control group health promotion program consisted unlimited amounts vegetarian food aerobic flexibility strength exercises hours day lectures health hours day massage practice hours day healthy cooking practice hour day effects intervention analyzed using mann whitney test wilcoxon signed rank test results intensive day health promotion program significantly reduced body weight body mass index triglyceride total cholesterol low density lipoprotein cholesterol blood glucose homeostasis model assessment insulin resistance time participants demonstrated increased back muscle leg muscle grip strength waist shoulder flexibility balance cardiorespiratory endurance conclusions intensive day health promotion program viable intervention improving body composition physical fitness glycemic control blood lipid levels young adults
background low birth weight extensively related poor adult health outcomes birth weight seen proxy environmental conditions prenatal development identical twin pairs discordant birth weight provide extraordinary model investigating association birth weight adult life health controlling genetics also postnatal rearing environment performed epigenome wide profiling blood samples pairs adult monozygotic twins discordant birth weight look molecular evidence epigenetic signatures association birth weight discordance results association analysis revealed cpg site genome wide statistical significance fdr either qualitative larger smaller quantitative discordance birth weight even selected samples extremely birth weight discordant twin pairs significant site found except cpgs displayed age dependent intra pair differential methylation fdrs among three sites intra pair differential methylation increased age decreased age genome wide statistical significance sex dependent effects intra pair differential methylation either whole samples extremely discordant twins conclusions genome wide dna methylation profiling reveal epigenetic signatures birth weight discordance although sites displayed age dependent intra pair differential methylation extremely discordant twin pairs
background major challenge bioinformatics era precision medicine identify molecular biomarkers complex diseases general expectation biomarkers signatures strong discrimination ability also readable interpretations biological sense generally conventional expressionbased network based methods mainly capture differential genes differential networks biomarkers however biomarkers focus phenotypic discrimination usually less biological functional interpretation meanwhile conventional function based methods could consider biomarkers corresponding certain biological functions pathways ignore differential information genes disregard active degree particular genes involved particular functions thereby resulting less discriminative ability phenotypes hence strongly demanded develop elaborate computational methods directly identify functional network biomarkers discriminative power disease states readable interpretation biological functions results paper present new computational framework based integer programming model named comparative network stratification cns extract functional interpretable network biomarkers strongly discriminative power disease states also readable interpretation biological functions addition cns recognize pathogen biological functions disregarded traditional expression based networkbased methods also uncover active network structures underlying dysregulated functions underestimated traditional function based methods validate effectiveness compared cns five state art methods gsva pathifier stsvm frsvm aep four datasets different complex diseases results show cns enhance discriminative power network biomarkers provide biologically interpretable information disease pathogenic mechanism biomarkers case study type diabetes demonstrates cns identify many dysfunctional genes networks previously disregarded conventional approaches conclusion therefore cns actually powerful bioinformatics tool identify functional interpretable network biomarkers discriminative power disease states readable interpretation biological functions cns implemented matlab package available http www sysbio chenlab images cnspackage rar
background physician survey conducted united states october february revealed wide variability hereditary angioedema hae management objective follow survey conducted assess impact newly available treatment options investigate changes hae care patterns methods march june physicians contacted hae treating physicians responded participants completed question online survey thatwas closely patterned initial survey although data analyzed descriptively selected questions underwent statistical analysis evaluate differences treatment patterns surveys results compared prior survey follow survey found proportion physicians reported danazol preferred long term prophylaxis agent declined conversely esterase inhibitor increased category percentage attacks self treated home increased decreases observed emergency department visits significant hospitalizations hae attacks percentage patients perceived physicians satisfied hae treatment increased convenience reported frequently important patient factor drove long term prophylaxis choice whereas adverse effects cited less frequently surveys cost insurance coverage greatest driver category conclusion analysis findings suggests change hae treatment increased self treatment home decreased emergency department visits hospitalizations provided greater patient satisfaction american academy allergy asthma immunology
background preceptorship model clinical teaching introduced support new graduate nurse education programme ireland little known model impacts upon pedagogical practices preceptor student learning clinical practice leading question constitutes effective teaching learning clinical practice undergraduate level aim study aimed explore clinical teaching learning within preceptorship model acute care hospital ireland identify best practice based current theoretical professional educational principles occurred method qualitative research study purposively selected sample students preceptors working together four clinical areas one hospital ireland methods semi structured interviews analysed thematically complemented documentary analysis relating teaching assessment students ethical approval gained hospital ethics committee findings preceptor student contact time within empowering student preceptor learning relationship foundation effective teaching learning assessment dialoguing talking practice enhanced students knowledge understanding ability preceptor ask higher order questions promoted students clinical reasoning problem solving skills insufficient time teach reliance students ability participate contribute practice minimal guidance found negatively impact students learning conclusions implications concepts cognitive apprenticeship scaffolding learning communities practice helpful understanding processes entailed preceptorship preceptors need extensive educational preparation support ensure pedagogical competencies necessary provide cognitive teaching techniques foster professional performance clinical reasoning national competency based standards preceptor preparation developed elsevier ltd rights reserved
background variety innate subsets lymphoid cells natural killer cells several populations innate lymphoid cells ilcs mucosal associated invariant mait cells innate like lymphocytes involved asthma may important effector functions asthmatic immune responses present study investigated whether cells ilcs mait cells peripheral blood patients asthma would associated clinical asthma parameters methods recruited adult patients mild severe asthma peripheral blood mononuclear cells peripheral venous blood samples patients purified stained different combinations appropriate antibodies cells analyzed flow cytometry results percentage activated cells total cell population negatively correlated fev calculated forced expiratory volume fev forced vital capacity fvc percentages ilcs ilcs negatively correlated fev fev percentage ilcs positively correlated bmi percentage mait cells negatively correlated fev moreover percentage cells ilcs ilcs ilcs mait cells positively correlated conclusions first time data showed activated cells ilcs ilcs ilcs mait cells positively correlated may associated airflow limitation patients asthma copyright japanese society allergology production hosting elsevier
background worldwide population suffers mental neurological substance use disorders unfortunately affected persons access treatment need data magnitude mental health problem kenya scarce objectives study establish prevalence socio demographic factors associated mental substance use disorders kosirai division nandi county western kenya methods cross sectional descriptive study participants selected simple random sampling sampling frame obtained data base population study area developed door door testing counseling exercises hiv aids four hundred twenty consenting adults interviewed psychologists using mini international neuropsychiatric interview version diagnostic statistical manual edition researcher designed social demographic questionnaire results one hundred ninety one participants lifetime diagnosis least one mental disorders anxiety disorder major depressive disorder alcohol substance use disorder experienced psychotic episode life time suicidal attempt ever diagnosed mental illness mental condition associated age less years medical condition conclusion large proportion community mental disorder lifetime conditions undiagnosed therefore treated findings indicate need strategies promote diagnosis treatment community members psychiatric disorders order screen people mental illness recommend research evaluate strategy similar home based counseling testing hiv use simple screening tools
background abuse methylphenidate treatment attentiondeficit hyperactivity disorder reported increasing among students purpose improving cognition methods single capsule containing methylphenidate placebo administered healthy young adults orally following hours sleep deprivation measurements included percent change score sleep deprived baseline four standardized tests cognitive function hopkins verbal learning digit span modified stroop trail making tests measurements also included percent changes blood pressure heart rate sleep deprived baseline plasma methylphenidate concentration results differences cognitive test performance observed intervention groups subjects receiving methylphenidate mean percent changes baseline systolic blood pressure heart rate increased relative placebo minutes following capsule administration maximum increases respectively timing peak differences physiologic measures correlate peak serum methylphenidate concentrations exit questionnaire ratings capsule effect perceived performance postcapsule administration challenging cognitive test higher respectively methylphenidate group placebo group conclusions cognitive improvement among sleep deprived young adults observed following methylphenidate administration benefits perceived abusers may relate increased confidence sense well well sympathetic nervous system stimulation moreover methylphenidate administration results physiologic effects could harmful certain individuals
background across industrialized world men experience earlier onset cardiovascular disease cvd life expectancy years shorter women low total testosterone concentrations men suggested novel cvd risk factor contribution gender gap less well studied methods used data individuals women men aged years longitudinal population based cohort study health pomerania germany multivariable poisson cox proportional hazard regression models used investigate risk incident cardiovascular morbidity year examination follow well cause cvd mortality year follow men women additionally added risk attributable low men percentile assessed results compared women men uniformly higher risk incident cardiovascular morbidity including overweight hypertension dyslipidemia metabolic syndrome type diabetes mellitus men also increased cause mortality hazard ratio year cvd risk compared women subgroup analyses men low showed highest year cvd mortality risk compared men higher women also negatively associated cardiovascular risk defined framingham risk score multivariable adjustment conclusions analyzing large population based sample observed men generally higher risk incident cardiovascular morbidity mortality furthermore men low concentrations identified high risk individuals regard year cvd mortality risk gend med elsevier journals inc rights reserved
background addicts specific internet applications involving communication features showed increased social anxiety emotional competence deficits impaired prefrontal related inhibitory control dorsal anterior cingulate cortex dacc likely plays important role cognitive control negative affect social exclusion pain anxiety aim assess social anxiety related inhibitory control specific internet addiction addicted use games social networks relation altered dacc activation methods controls specific internet addicts completed anxious words based affective task agn subsample healthy controls specific internet addicts underwent functional magnetic resonance imaging fmri completing emotional stroop task est socially anxious positive negative neutral words subgroups internet gaming social network addicts exploratively assessed psychometric measures social anxiety emotional competence impulsivity additionally explored results specific internet addicts showed higher impulsivity social anxiety reduced emotional competence group differences agn est behavioral measures detected group differences found dacc explorative analyses revealed decreased left middle superior temporal gyrus activation interference socially anxious words internet gaming relative social network addicts
background adhering antiretroviral therapy reduces rate disease progression death among people living human immunodeficiency virus though manifold factors reported determinant factors antiretroviral therapy adherence status perhaps determinants non adherence differ activities patients study setting methods institution based unmatched case control study conducted aksum town individuals month follow complete individual information included study document review interviewer based techniques used collect data binary logistic regression analysis used identify determinant factors non adherence results total cases control study participants included study majority male sex years duration art aor history adverse effect aor substance use aor living parents aor depression symptom aor cells cluster differentiation count aor low dietary diversity aor found significant determinants non adherence antiretroviral drug conclusion program social individual related factors showed statistically significant associated nonadherence antiretroviral therapy managing lifestyle developing self efficacy individuals treating related threat improve adherence status antiretroviral therapy recommended study
background adnexal tumours frequently diagnosed asymptomatic postmenopausal women due liberal use modern high resolution imaging study objective determine would difference intervention rates using simple rules management protocol srmp compared risk malignancy index royal college obstetricians gynaecologists guideline rmi rcog methods prospective randomised controlled trial participants researchers non blinded surgeons pathologists blinded recruited pain free postmenopausal women diagnosed adnexal tumour ultrasound scan women randomised either two protocols determined offered conservative surgical management intention treat analysis performed primary outcome measure rate surgical interventions ovarian cysts months randomisation secondary outcome measures number staging surgical procedures surgical complications number delayed diagnoses ovarian cancer results total women randomised months rmi rcog arm srmp arm outcome data months two groups balanced terms age length time since menopause use hormone replacement therapy women rmi rcog arm surgery women srmp arm chi test difference proportions confidence interval relative risk significant differences number staging surgical procedures surgical complications two groups delayed diagnoses ovarian cancer months conclusions surgical intervention rates asymptomatic postmenopausal women ultrasound diagnosis adnexal tumours significantly lower novel srmp protocol used triaging compared standard rmi rcog protocol without increase delayed malignant diagnoses
background adolescence young adulthood important developmental periods screening health compromising behaviours mental health disorders routine primary care visits potential assist clinicians identify areas concern provide appropriate interventions objective systematic review investigate whether screening subsequent interventions multiple health compromising behaviours mental health disorders primary care settings improves health outcomes young people methods using preferred reporting items systematic reviews meta analyses prisma guidelines literature searches conducted medline psycinfo scopus cochrane library databases prospero registration number crd using search terms representing four thematic concepts primary care young people screening mental health health compromising behaviour eligible inclusion studies include measure health outcome include least participants aged years use screening tool assessed one health domain conducted within primary care setting risk bias assessed using quality rating scale results articles identified nine studies fulfilled inclusion criteria reviewed two randomised controlled trials rcts one pilot rct two clustered rcts one randomised study multiple intervention groups control group one cluster rct two active arms one longitudinal study one pre post study seven studies including two rcts one clustered rct found positive changes substance use diet sexual health risky sexual behaviour alcohol related risky behaviour social stress stress management helmet use sleep exercise two studies reporting harms one reported negative health outcome increased alcohol use conclusions evidence use screening intervention young people mental health disorder health compromising behaviours clinical settings improves health outcomes along evidence young people value discussions health risks providers discussions part routine primary care young people quality studies needed strengthen evidence
background adolescence vulnerable period afflicted inflammatory bowel disease ibd limited knowledge factors influencing transition readiness population sought determine whether self efficacy resilience would informative predictors transition readiness independent age methods patients ibd aged years cared pediatric setting prospectively enrolled entry patients filled transition readiness assessment questionnaire traq ibd self efficacy scale adolescent ibd ses connor davidson resilience scale demographic data disease specific information collected medical record provider general linear modeling autocorrelation performed investigate predictors transition readiness results eighty seven patients crohn disease ulcerative colitis included median age years interquartile range min max controlling age ibd ses predicted traq accounting variance connor davidson resilience scale also independently predicted traq score accounting variance ibd ses connor davidson resilience scale significantly auto correlated final predictive model ibd ses predictive traq none patients demographic disease socioeconomic parameters informed transition readiness self efficacy resilience considered conclusions first study identify reliable predictor transition readiness scores adolescents ibd seem influenced age
background advancements research clinical care considerably extended life expectancy cystic fibrosis patients however extended survival come comorbidities one leading morbidities related bone disease cfbd progresses disease severity places patients high risk fractures particularly ribs vertebrae evidence patients vertebral fractures higher bone mineral density bmd nonfracture group led postulate bone quality impaired patients therefore examined rib specimens resected time lung transplant patients measure parameters bone quantity quality methods exploratory study analysed end stage control rib specimens resected otherwise healthy lung donors bmd bone microarchitecture static parameters bone formation resorption microcrack density rib specimens quantified imaging histomorphometric histological methods variables reflecting mineralization ribs assessed digitized microradiography degree bone mineralization heterogeneity index mineralization calculated trabecular cortical bone results compared controls ribs exhibited lower areal trabecular volumetric bmd decreased trabecular thickness osteoid parameters increased microcrack density particularly pronounced specimens patients related diabetes static parameters bone resorption similar groups degree mineralization total bone heterogeneity index increased specimens conclusion combination reduced bone mass altered microarchitecture imbalanced bone remodeling maintained bone resorption decreased formation increased microdamage small increase degree mineralization may lead decreased bone strength coupled chronic coughing chest physical therapy may provide explanation increased incidence rib fractures previously reported population elsevier inc rights reserved
background affective dysregulation core feature bipolar disorder inter episodic affect lability associated severe outcomes including comorbidity rates daily tobacco smoking substance use disorders high knowledge regarding relationships affective lability abuse commonly used substances tobacco alcohol cannabis limited methods investigated whether dimensions inter episodic affective lability measured affective lability scale short form als associated lifetime daily tobacco use alcohol aud cannabis use disorders cud sample french norwegian patients results als total score sub dimensions anxiety depression depression elation anger significantly associated aud depression elation sub dimension associated cud controlling possible confounders gender age interview age illness onset subtype duration illness substance use disorders daily tobacco smoking significantly associated affective lability limitations data recent substance use psychiatric comorbidities personality hyperkinetic disorders available could mediated relationships conclusion aud associated several dimensions inter episodic affective lability cud associated increased oscillations depression elation increased affective lability may partly explain increased illness severity patients aud cud affective lability treated order prevent comorbidities
background african american black hispanic persons living hiv aabh plwh evidence insufficient engagement hiv care low uptake hiv antiretroviral therapy leading suboptimal clinical outcomes present qualitative study used critical race theory incorporated intersectionality theory understand aabh plwh perspectives mechanisms structural racism macro level systems reinforce inequities among racial ethnic groups influence health decisions behaviors methods participants adult aabh plwh new york city taking antiretroviral therapy well engaged hiv care participants purposively sampled maximum variation larger study engaged semi structured depth interviews audio recorded professionally transcribed verbatim data analyzed using systematic content analysis approach results found aabh plwh experienced hiv care medication decisions historical cultural lens incorporating knowledge past present structural racism contextual knowledge included awareness past maltreatment people color medical research understandings linked history hiv antiretroviral therapy including awareness first hiv antiretroviral regimen namely azt zidovudine mono therapy initially prescribed unacceptably high doses causing serious side effects modest efficacy historical cultural context aspects structural racism negatively influenced health care decisions behavior four main ways via extent healthcare settings experienced overly institutionalized therefore dehumanizing distrust medical institutions healthcare providers led aabh plwh feel pressured take hiv antiretroviral therapy offered perceptions patients excluded health decision making process emphasis antiretroviral therapy compared non hiv related priorities found although participants located intersection multiple social categories gender social class aabh race ethnicity race ethnicity social class described primary factors conclusions critical race theory proved useful uncovering macro level structural racism affects individual level health decisions behaviors hiv clinical settings counter balance effects structural racism building structural competency interventions fostering core self determination needs including autonomy may prove culturally appropriate beneficial aabh plwh
background age related decline kidney function important risk factor cognitive impairment older adults study examined several kidney function measures association cognitive function older adults hope identify early sensitive markers used detection screening cognitive impairment methods total older participants aged years national health nutrition examination survey analyzed association kidney function cognitive impairment using multivariate logistic regression general linear models cognitive functioning assessed household interview using version digit symbol substitution test wechsler adult intelligence scale iii study participants score percentiles distribution unable complete sample exercise due cognitive limitations classified cognitive impairment results older adults cognitive impairment weighted prevalence among kidney function measures examined levels serum cystatin urinary albumin found significantly associated cognitive impairment adjusting age sex race ethnicity poverty status education physical activity bmi cigarette smoking alcohol consumption cognitive functioning scores significantly decreasing increasing levels kidney dysfunction markers conclusion serum cystatin urinary albumin early markers chronic kidney disease might serve early effective markers cognitive decline older adults mechanisms underlying observed association need characterized elsevier rights reserved
background alterations gray matter development represent potential pathway childhood abuse associated psychopathology several prior studies find reduced volume thickness prefrontal pfc temporal cortex regions abused compared nonabused adolescents although prior research based adults volume based measures study tests hypothesis child abuse independent parental education predicts reduced cortical thickness prefrontal temporal cortices well reduced gray mater volume gmv subcortical regions adolescence methods structural mri scans obtained adolescents exposed physical sexual abuse nonabused adolescents ages abuse operationalized using dichotomous continuous measures examined associations abuse brain structure several priori defined regions controlling parental education age sex race total brain volume subcortical gmv significance evaluated false discovery rate correction results child abuse exposure severity associated reduced thickness ventromedial prefrontal cortex pfc right lateral orbitofrontal cortex right inferior frontal gyrus bilateral parahippocampal gyrus phg left temporal pole bilateral inferior right middle right superior temporal gyri neither abuse measure predicted cortical surface area subcortical gmv bilateral phg thickness inversely related externalizing symptoms conclusions child abuse experience characterized high degree threat associated reduced cortical thickness ventromedial ventrolateral pfc medial lateral temporal cortex adolescence reduced phg thickness may mediator linking abuse externalizing psychopathology although prospective research needed evaluate possibility
background although hypertension guidelines define treatment resistant hypertension blood pressure uncontrolled antihypertensive medications including diuretic unknown whether patient prognosis differs diuretic included methods participants antihypertensive lipid lowering treatment prevent heart attack trial allhat randomly assigned first step therapy chlorthalidone amlodipine lisinopril year follow visit average blood pressure systolic diastolic antihypertensive medications blood pressure antihypertensive medications identified apparent treatment resistant hypertension prevalence treatment resistant hypertension association allhat primary combined fatal coronary heart disease nonfatal myocardial infarction secondary cause mortality stroke heart failure combined coronary heart disease combined cardiovascular disease outcomes identified treatment group results participants assigned chlorthalidone amlodipine lisinopril respectively treatment resistant hypertension mean follow years primary outcome incidence similar assigned chlorthalidone compared amlodipine lisinopril amlodipine chlorthalidone adjusted hazard ratio confidence interval lisinopril chlorthalidone adjusted secondary outcome risks similar comparisons except coronary revascularization higher amlodipine chlorthalidone treated analysis based diuretic use produced similar results conclusions study titrated medications goal participants assigned chlorthalidone less likely develop treatment resistant hypertension however prognoses treatment resistant hypertension similar across treatment groups elsevier inc rights reserved
background although past decade management invasive fungal infections improved number controversies persist regarding empirical antifungal treatment critically ill hematology patients aims identify key clinical knowledge elaborate set recommendations high level consensus necessary approach fungal infections critically ill hematology patients methods spanish prospective questionnaire measures consensus delphi technique anonymously answered mailed multidisciplinary national experts specialists fungal invasive infections six scientific national societies intensivists anesthesiologists microbiologists pharmacologists specialists infectious diseases responded questions prepared coordination group thorough review literature published last years category selected level agreement among experts category must equal greater second round specialists attended face face meeting held extracting recommendations chosen topics validated pre selected recommendations derived algorithm results assess administering antifungal treatment patients high medium risk factors fever days onset antibiotic therapy event negative galactomannan detection analysis performed relevant findings sinus chest computed tomography detected case patient receive prophylaxis administered fluconazole caspofungin treatment recommended event patient received prophylaxis azole activity filamentous fungi administration liposomal amphotericin recommended caspofungin second choice therapy event prophylaxis received echinocandin liposomal amphotericin therapy recommended voriconazole second choice assess administering antifungal treatment patients high medium risk factors fever days onset antibiotic therapy event positive galactomannan sinus chest suggests fungal infection caused filamentous fungi event patient receive antifungal prophylaxis administered fluconazole recommended treatment choice voriconazole liposomal amphotericin patient received prophylaxis azole activity filamentous fungi administration liposomal amphotericin caspofungin recommended monotherapy liposomal amphotericin combination voriconazole anidulafungin recommended second choice therapies event echinocandin administered prophylaxis liposomal amphotericin voriconazole recommended treatments choice consider administration antifungal treatment patients high medium risk factors fever days onset antibiotic therapy event negative galactomannan sinus chest suggests fungal infection caused filamentous fungi patient receive prophylaxis administered fluconazole recommended treatment choice liposomal amphotericin voriconazole case patient received prophylaxis azole activity filamentous fungi administration liposomal amphotericin recommended first choice therapy liposomal amphotericin combined caspofungin second choice event echinocandin administered prophylaxis liposomal amphotericin voriconazole recommended treatments choice conclusions empirical antifungal approach critically ill hematology patients requires application broad range knowledge skills described recommendations algorithm recommendations based delphi methodology may help identify potential patients standardize management improve overall prognosis asociacion espafiola micologia published elsevier espana rights reserved
background although suggested generalized joint hypermobility gjh risk factor injury soccer players remains unclear whether applies elite female soccer players purpose investigate whether gjh risk factor injury elite female soccer players study design cohort study level evidence methods elite female soccer players netherlands screened start competitive season gjh assessed using beighton score soccer injuries soccer exposure registered throughout entire season poisson regression performed calculate incidence risk ratios irrs using different cutoff points beighton score indicate gjh results players included study classified hypermobile beighton score mean injury incidence per player injuries hours soccer significant difference hypermobile nonhypermobile players gjh risk factor injuries using beighton score cutoff points irr irr irr similarly gjh significant risk factor thigh knee ankle injuries evaluated separately conclusion study indicates gjh risk factor injuries elite female soccer players irrespective beighton score cutoff point hypermobile players elite level might improved active stability used braces compensate joint laxity
background although mentoring involves achievement mutual relationship mentors mentees studies focused effects mentoring mentees rather mentors necessitates need identify mentors experiences provide original resources mentoring objectives purpose study explore mentoring experience nursing students participated mentors mentoring learning program offer evidence based resources nursing educators develop mentoring programs use mentorship educational method design qualitative content analysis transcribed focus groups conducted describe explore undergraduate nursing students mentoring experiences setting study conducted two nursing schools south korea participants fifteen student mentors peer mentoring program participated present study aged years participants female methods experiences mentors explored focus groups collected data analyzed content analysis results mentors experiences could summarized core theme self growth leader consisting following themes taking pride guiding mentees coping conflicts building leadership conclusion themes codes derived mentors experiences would provide evidence based guidelines resources nursing educators professionals related disciplines regarding successful peer mentoring could facilitate self growth foster development leadership skills undergraduate students elsevier ltd rights reserved
background although researchers identified strong associations emergent literacy early childhood later conventional reading skills typically developing children unclear whether associations extend children autism spectrum disorder asd method analyzed degree three emergent literacy skills alphabet knowledge print concept knowledge phonological awareness children ages three five years old asd predicted decoding degree associations differed comparison group children hypothesized emergent literacy skills would predict later decoding groups children autism status would moderate association print concept knowledge decoding results found phonological awareness statistically significant predictor later decoding children asd find evidence asd status moderated relationships emergent literacy skills decoding conclusions based findings early educators consider emergent literacy skills important learning targets young children asd children without disabilities furthermore phonological awareness might even important young children asd children without disabilities elsevier ltd rights reserved
background alzheimer disease one disabling diseases affect large numbers elderly people worldwide characteristics disease patients require daily assistance service providers nursing homes home domiciliary assistance demonstrated cost effective efficient first phase disease helping slow course illness improve quality life care extend independence patients caregivers context aim work demonstrate technical effectiveness acceptability innovative domiciliary smart sensor system providing domiciliary assistance patients developed ambient assisted living aal approach methods design development testing evaluation innovative technological solution performed multidisciplinary team sociomedical operators patients directly involved defining end users needs requirements identifying design principles acceptability usability features evaluating technological solutions real experimentation results modular technological system produced help caregivers continuously monitor health status safety daily activities patients experimentation acceptability utility usability efficacy system evaluated quite positive conclusion experience described article demonstrated aal technologies feasible effective nowadays actively used assisting patients homes extensive involvement caregivers experimentation allowed assess use technological system proven improvement care performance efficiency care provision formal informal caregivers consequently increase quality life patients relatives caregivers
background american cocker spaniels overrepresented among breeds require surgery treatment end stage otitis externa however prevalence otitis externa breed remains unknown reviewed year medical records private veterinary clinics finland determine prevalence american cocker spaniels compared english cocker english welsh springer spaniels american cocker spaniel owner questionnaire designed identify potential risk factors end stage results medical records dogs prevalence highest welsh springer spaniels confidence interval followed american cocker english springer english cocker spaniels mean number episodes ear diseased dogs number ear surgeries highest american cocker spaniels owner questionnaires received american cocker spaniels suffered dogs occurred without concurrent skin lesions displayed first signs year age dogs signs recurred within month continued despite treatment required surgery euthanized operated dogs others due severe onset age year significantly increased risk end stage conclusions prevalence american cocker spaniels finland higher previously reported cocker spaniels highest prevalence found welsh springer spaniels compared spaniels often recurrent frequently surgically managed american cocker spaniels based questionnaire early onset year increased risk end stage american cocker spaniels requires intensive approach first treatment prevention recurrence emphasised causes treatment breed warrant study
background amygdala hyper reactivity sometimes assumed vulnerability factor predates depression however healthy people experience early life stress become depressed may represent resilience mechanism aimed test hypothesis examining whether increased amygdala activity association history early life stress els negatively positively associated depressive symptoms impact negative life event stress never depressed adults methods twenty four healthy participants completed individually tailored negative mood induction task functional magnetic resonance imaging fmri assessment along evaluation els results mood change amygdala reactivity increased never depressed participants reported els compared participants reported els yet increased amygdala reactivity lowered effects els depressive symptoms negative life events stress amygdala reactivity also positive functional connectivity bilateral dlpfc motor cortex striatum people els sad memory recall conclusions increased amygdala activity els associated decreased symptoms increased neural features consistent emotion regulation suggesting preservation robust amygdala reactions may reflect stress buffering resilience enhancing factor depression negative stressful events
background estimated one billion children experience child abuse year highest rates low middle income countries sinovuyo teen programme part parenting lifelong health unicef initiative develop test violence prevention programmes implementation low resource contexts objectives parenting support programme prevent abuse adolescents improve parenting reduce adolescent behavioural problems trial aims evaluate effectiveness sinovuyo teen compared attention control group water hygiene programme methods design pragmatic cluster randomised controlled trial stratified randomisation settlements rural peri urban study clusters eastern cape south africa settlements receive either session parenting support programme day water hygiene programme primary outcomes child abuse parenting practices secondary outcomes include adolescent behavioural problems mental health social support concurrent process evaluation qualitative research conducted outcomes reported primary caregivers adolescents brief follow measures collected immediately intervention full follow measures collected months post intervention month follow planned depend financial practical feasibility given delays related high levels ongoing civil political violence research sites discussion first known trial parenting programme prevent abuse adolescents low middle income country study also examine potential mediating pathways moderating factors
background individual subjective perception well increasingly recognized essential complement clinical symptomatology functional impairment children mental health measurement quality life qol potential give due weight child perspective scope methodology aim critically review current evidence childhood mental disorders affect qol first major challenges research field outlined present systematic review qol children adolescents aged years formally diagnosed mental behavioural disorder compared healthy typically developing children children health conditions finally discuss limitations current evidence base future directions based results systematic review relevant literature findings conclusions systematic review identified eligible studies published year originated europe majority examined qol neurodevelopmental disorders including attention deficit hyperactivity disorder autism spectrum disorder motor disorders intellectual disability despite substantial heterogeneity studies demonstrate self reported global qol significantly reduced compared typical healthy controls across several disorders qol dimensions parents ratings average substantially lower casting doubt validity proxy report studies large diagnostic groups depressive disorders anxiety disorders early onset schizophrenia eating disorders largely lacking conclude representative well characterized normative clinical samples well longitudinal qualitative designs needed clarify construct qol derive measures high ecological validity examine qol fluctuates time attributable specific conditions contextual factors
background angioedema due hereditary deficiency inhibitor causes temporarily disability guidelines recommend early demand treatment attacks reduce morbidity prospective observational study evaluated efficacy demand approach methods january august data attacks treatments collected patients centre milan results total attacks reported treated approved therapies pdc inh icatibant tranexamic acid treated attack locations peripheral cutaneous abdominal multiple facial laryngeal attack severities moderate mild severe median attack duration data available attacks approved therapies significantly shorter without treatment tranexamic acid treatments self administered icatibant inh median attack duration icatibant inh median time onset symptoms drug administration icatibant cinh median time drug administration complete resolution respectively second treatment required icatibant treated attacks pdc inh treated attacks conclusion study provides evidence demand treatment effective reducing disease related morbidity use demand treatment italy increased attacks last years reflecting better adherence international guidelines
background animals show seasonal changes endocrine immune system response vvinter stressors even though increased inflammation implicated pathophysiology depression whether immune disorder key mediator seasonal affective depression sad unknown hypothesized short photoperiods vvinter may induce inflammatory response contributes sad light treatments normalize immune function improve depressive symptoms methods twenty patients vvith diagnosis sad score ham higher recruited study twenty one healthy subjects personal family history psychiatric disorder matched patients according age sex patients controls sampled winter november january inclusive subset sad patients sampled weeks light therapy blood samples assayed macrophage activity lymphocyte proliferation cytokine release results sad patients showed significantly higher macrophage activity lower lymphocyte proliferation winter compared healthy subjects concentrations macrophage produced proinflammatory cytokines interleukin beta tumour necrosis factor alpha helper produced cytokine interferon significantly increased contrast significant changes produced cytokines observed light therapy significantly improved depressive scores associated attenuation decreased lymphocyte functions increased macrophage activity level proinflammatory cytokines conclusion sad patients increased macrophage thl type responses winter light therapy normalized immune functions depressive symptoms results support inflammatory hypothesis sad immunomodulatory role light lherapy elsevier rights reserved
background ankle joint injuries extremely common sports injuries anterior talofibular ligament involved majority ankle sprains large magnetic resonance imaging mri studies associated structural injuries ankle sprains purpose describe injury pattern athletes referred mri assessment acute ankle sprain assess risk associated traumatic tissue damage including lateral syndesmotic ligament involvement study design cross sectional study level evidence methods total ankle mri scans athletes acute ankle sprains evaluated lateral syndesmotic ligament injury concomitant injuries deltoid spring ligaments sinus tarsi peroneal flexor extensor retinacula tendons traumatic nontraumatic osteochondral osseous changes joint effusion patients average years old average time injury mri days six exclusive injury patterns defined based lateral syndesmotic ligament involvement risk associated injuries assessed logistic regression using ankles low grade lateral ligament injuries syndesmotic ligament damage reference results regard injury pattern ankles complete anterior talofibular ligament disruption syndesmotic injury ankles syndesmotic injury without lateral ligament damage acute osteochondral lesions lateral talar dome seen ankles percentage chronic lateral osteochondral lesions risk talar bone contusions increased fold ankles complete lateral ligament ruptures adjusted odds ratio aor ankles syndesmotic involvement risk associated deltoid ligament injuries increased ankles complete lateral ligament injuries aor compared patients low grade lateral ligament injuries conclusion athletes referred mri suffering acute ankle sprain evidence syndesmotic injury regardless lateral ligament involvement half evidence lateral ligament injury without syndesmotic involvement concomitant talar osseous deltoid ligament injuries common
background anti cancer treatment may reduce fertile life span induce premature menopause review aims provide overview available literature effects chemotherapy incidence ovarian dysfunction evaluate relationship dose chemotherapy age time treatment time since treatment female survivors childhood young adult cancer methods comprehensive search electronic databases performed search date december results studies included describing total female survivors median age menopause earlier cancer survivors general population prevalence amenorrhoea varied exposed mvpp protocols highest risk amenorrhoea breast cancer survivors receiving cyclophosphamide containing regimens prevalence amenorrhoea important risk factors ovarian dysfunction alkylating agents specifically procarbazine busulfan older age treatment conclusion breast cancer survivors treated procarbazine alkylating agents higher age diagnosis highest risk diminished ovarian function however studies included review showed methodological limitations imperative nation wide registries guarantee long term follow adult life cancer survivors elsevier ltd rights reserved
background antipsychotics essential treatment schizophrenia however due side effects continuity treatment patients general health jeopardized drugs especially clozapine class side effects attributed antimuscarinic properties dysmotility condition muscles digestive system become impaired dysmotility may also alter speed strength coordination digestive organs causing distention disturbing gastrointestinal transit leading symptoms bloating nausea vomiting even malnutrition study aim develop vivo assay capable identifying studying antimuscarinic effects antipsychotics zebrafish model methods performed video recordings vivo day postfertilization dpf zebrafish larvae gastrointestinal tracts analyzed frequency spontaneous regular cycles contractions gut key results assay first validated treatment atropine showed antimuscarinic drug reduces peristaltic cycles subsequently larvae treated antipsychotics haloperidol risperidone clozapine neither haloperidol risperidone reduced gut motility clozapine significantly reduced frequency cycles contractions confirms existing clinical data conclusions inferences conclude zebrafish assay efficiently identifies anticholinergic side effects antipsychotics thus quick useful way screen property new drugs
background aripiprazole lauroxil extended release prodrug aripiprazole intramuscular injection approved schizophrenia treatment developed population pharmacokinetic poppk model characterize aripiprazole lauroxil evaluate dosing scenarios likely encountered clinical practice methods data patients schizophrenia collected clinical studies used construct poppk model model subsequently used evaluate various dose levels frequency impact dosing delay aripiprazole concentrations findings results model indicate aripiprazole released systemic circulation days release continues additional days slow increase aripiprazole concentration injection necessitates coadministration oral aripiprazole days first injection based poppk model simulations dosing interval every weeks results aripiprazole concentrations fall within concentration range associated efficacious aripiprazole lauroxil dose range dosed monthly monthly dose also resulted aripiprazole concentrations within efficacious dose range aripiprazole lauroxil administration results prolonged exposure dose delays weeks depending dose regimen require oral aripiprazole supplementation upon resumption dosing conclusions poppk model model based simulations effective means evaluating aripiprazole lauroxil dosing regimens management missed doses analyses play important role determining use long acting antipsychotic clinical practice
background asparaginase important component pediatric acute lymphoblastic leukemia therapy unfortunately treatment hampered hypersensitivity reactions general allergies regardless severity cause complete inactivation drug however report atypical allergic reactions without inactivation asparaginase called allergic like reactions procedure patients allergic like reaction treated according dutch childhood oncology group coall protocol described reactions identified continual measurement asparaginase activity levels characteristics including timing occurrence symptoms grade presence antiasparaginase antibodies compared real allergies results fourteen allergic like reactions occurred nine patients five reactions pegas paraginase nine erwinia asparaginase allergic like reactions occurred relatively late start infusion compared real allergies antibodies absent one patient allergic like reaction detected patients real allergy symptoms grade differ groups asparaginase continued formulation six patients four finished treatment adequate activity levels conclusions conclusion allergic like reactions occur relatively late start infusion without antibodies despite clinical differences allergic like reactions distinguished real allergies continually measuring asparaginase activity levels clinically tolerated formulations switched case allergic like reactions moreover failure recognize reactions may lead less favorable prognosis asparaginase therapy terminated unnecessarily
background asthma global problem prevalence varies among different countries cities aimed obtain prevalence describe characteristics discover factors may relate asthma hangzhou methods cross sectional study conducted hangzhou subjects children aged years younger control group non asthma children matched age sex asthmatic patient also randomly selected interviewed international study asthma allergies childhood national epidemiology study asthma allergies china questionnaires used survey results questionnaired children children diagnosed asthma guardians regarded cost asthma management affordable tolerable intolerable guardians children absent work school due children asthma respiratory tract infection common trigger asthma attacks common causes included cold air house dust exercise fish shrimp pollen interestingly also found children years older triggers happened children years younger factors included exercise emotional changes house dust pollen renovation works home mosquito repellent incense pets values compared factors may relate asthma development higher percentage family history asthma personal history allergy atopic dermatitis drug allergy food allergy comorbidities allergic rhinitis sinusitis adenoidal hypertrophy urticaria caesarean birth complications ever happened pregnancy discovered asthma children non asthma children values exclusive breastfeeding within first months keeping animals higher percentage non asthma children asthma values inhaled corticosteroid ics ics long acting beta agonists laba applied patients traditional chinese medicine tcm used asthma children leukotriene receptor antagonist ltra used adherence scored higher tcm ics ics laba ltra conclusions conclusion conducted epidemiology study hangzhou prevalence childhood asthma asthma economic social burden children guardians risk factors asthma development may include caesarean birth personal history allergy concomitant allergic diseases exclusive breastfeeding within first months keeping animals might protecting factors tcm really popular china besides ics ics laba ltra
background asthma heterogeneous disease characterised chronic inflammatory airways affected several immunological factors one discussed researched hypotheses relationship vitamin serum levels asthma study aimed investigate relationship vitamin serum levels asthma pulmonary functions children kurdistan province iran materials methods case control study children ranging years referred summer investigation participants divided two groups asthma group control group serum separation samples analysed using vitamin elisa kit additionally pulmonary function test serum ige levels measured groups data analysed using chi square test multiple regression analysis spss results difference shown groups terms gender composition male female average vitamin serum level case group less control group addition difference vitamin deficiency level suboptimal asthma control group statistically significant positive correlation existed vitamin levels fev fvc fev fvc multiple regression analysis showed reverse relationship vitamin levels ige serum levels remained adjustment potential confounders age sex bmi fev fvc conclusion results showed serum levels vitamin asthma patients less healthy people also reduced lung function patients serum levels vitamin asthma patients must checked continuously seicap published elsevier espana rights reserved
background atopic dermatitis chronic skin disease known negatively influence mental health patients however studies explored prevalence psychiatric problems among patients particularly among adolescents study aimed assess association depressive symptoms suicidal behaviors among adolescents analyzing data korean youth risk behavior survey nationwide web based survey methods data adolescent middle high school students korea analyzed students self reported diagnosed doctor yes answers questions depressive symptoms suicide ideation suicide planning suicide attempts analyzed relationships depressive symptoms suicidal behaviors tested logistic regression models controlling potential confounding factors results proportion adolescents proportion adolescents reporting depressive feelings suicide ideation suicide planning suicide attempts compared adolescents without adolescents significantly likely experience depressive feelings odds ratio confidence interval suicide ideation suicide planning suicide attempts multivariate model relationships suicide ideation suicide planning suicide attempt statistically significant conclusion adolescents associated higher prevalence depression symptoms suicidal behaviors adolescent patients may need interventions clinicians caregivers use holistic approach prevent psychological comorbidities although research needed clarify relationship
background atopic dermatitis characterized heterogeneous clinical spectrum forms associated initial steps allergic march aims study determine phenotypes school age children investigate associations allergic march cluster methods included children years current children health environmental research study year prospective follow study year survey intervals latent class analysis used serum thymic stromal lymphopoietin tslp levels time enrollment measured using elisa results identified four current phenotypes children characterized early onset low atopy sample group early onset high atopy high eosinophil percentages group late onset low atopy group late onset high atopy normal eosinophils group although groups demonstrated high atopic burden children group showed persistence eosinophilia associated high prevalence new cases bronchial hyper responsiveness asthma symptoms follow serum level significantly increased early onset groups significant difference serum tslp levels across four groups conclusion allergic march associated phenotype exists characterized early onset persistence increased serum levels high atopy persistently increased blood eosinophil percentage
background atrial arrhythmias aas frequent lung transplantation late postoperatively several predictive factors early postoperative aas identified late aas remain unknown whether affects mortality still debated study assessed large cohort patients incidence aas early late surgery predictive factors effect mortality methods results studied consecutive patients years mean follow years patients developed postoperative aas age odds ratio confidence interval chronic obstructive pulmonary disease independent predictive factors early aas late aas occurred years transplant patients pretransplant systolic pulmonary arterial pressure ptspap independent predictive factor late double associated long term freedom atrial fibrillation atrial flutter afl early late surgery effect mortality double associated better survival conclusions early following common contrast low occurrence late often organized early late aas affect mortality ptspap independent predictor late double protects late afl
background atrial fibrillation one common complications cardiac surgeries incidence postoperative risen continuously past decades associated lengthened hospital stays risk stroke sought study relationship pulmonary artery pressure pap occurrence coronary artery bypass graft surgery cabg methods prospective observational study designed assess relationship pap occurrence post cabg patients chronic paroxysmal surgery excluded patients complete evaluation via echocardiography ecg laboratory testing patients monitored days surgery tachycardia monitored noted study population divided groups postoperative without results selected patients sinus rhythm results confirmed occurrence rate cabg higher older patients univariate multivariate analyses showed significant relationship higher occurrence rate post cabg higher pap mean value patients respectively conclusions although age important predictor occurrence cabg past present studies many variables affecting occurrence among variables evaluated study higher pap significant predictor higher occurrence rate following cabg
background autism spectrum disorder asd neurodevelopmental disease characterized difficulties social communication unusually restricted repetitive behavior interests specific abnormalities language perception precise etiology asd still unknown probably heterogeneous subgroup patients toxic environmental exposure might lead imbalance oxidative stress anti oxidant systems previous serum postmortem studies measuring levels glutathione gsh main cellular free radical scavenger brain supported hypothesis compound might play role pathophysiology autism methods using method single voxel proton magnetic resonance spectroscopy mrs analyzed gsh signal dorsal anterior cingulate cortex dacc dorsolateral prefrontal cortex dlpfc asd patients normal average iqs matched control subjects hypothesized would find decreased gsh concentrations regions results find overall group differences neurometabolites including gsh neither dorsal acc wilks lambda test dlpfc dacc found trend decreased gsh signals asd patients conclusions unable confirm working hypothesis regarding decreased gsh concentrations asd group studies combining mrs serum cerebrospinal fluid measurements gsh metabolism including regions interest even whole brain spectroscopy needed
background autochthonous hepatitis occurs sporadically developed countries consumption undercooked pork containing hepatitis virus genotype hev hev major risk factor infection serological diagnostic kits currently used hospitals sometimes produce false negative positive results therefore detection hev rna antibodies virus required confirmative diagnosis hepatitis objectives aimed detect hev serum samples patients cryptogenic hepatitis determine origin hev study design nested polymerase chain reaction pcr method developed detection hev hev patients hepatitis total serum samples deposited patients acute cryptogenic hepatitis serologically negative hepatitis examined using method amplified pcr products genetically analyzed results four hev isolates detected serum samples phylogenetic analysis indicated three four isolates closely related hev isolates found pigs korea patients hepatitis japan conclusions newly developed nested pcr method useful detection hev patients cryptogenic hepatitis close relationship human hev isolates identified study swine isolates implied zoonotic transmission hev might source infection patients hepatitis elsevier rights reserved
background avascular necrosis avn psoriasis pathogenic mechanisms associated conditions common objective examine association psoriasis avn methods study used data taiwan national health insurance research database period identified patients psoriasis matched age sex controls without psoriasis taiwan longitudinal health insurance database multivariate cox proportional hazards models used analysis results unadjusted risk avn significantly higher patients psoriasis controls hazard ratio remained significant adjustment risk factors adjusted confidence interval risk avn increased relation psoriasis severity higher patients psoriasis arthritis patients without arthritis adjusted hrs higher male patients female patients patients younger years compared older patients limitations lacked information daily tobacco use alcohol consumption physical activity conclusion risk avn increased disease severity psoriasis
background bacteria present cave often survive modifying metabolic pathway mechanism understanding adopted bacteria survival strategy inside cave important aspect microbial ecology present study focuses bacterial community geochemistry five caves mizoram northeast india objective study explore taxonomic composition presumed functional diversity cave sediment metagenomes using paired end illumina sequencing using region rrna gene bioinformatics pipeline results actinobacteria proteobacteria verrucomicrobia acidobacteria major phyla five cave sediment samples among five caves highest diversity found lamsialpuk shannon index lowest bukpuk shannon index addition imputed metagenomic approach used predict functional role microbial community biogeochemical cycling cave environments functional module showed high representation genes involved amino acid metabolism carbohydrate metabolism kegg pathways genes responsible carbon degradation carbon fixation methane metabolism nitrification nitrate reduction ammonia assimilation also predicted present study conclusion cave sediments biodiversity hotspot region possessing oligotrophic environment harbours high phylogenetic diversity dominated actinobacteria proteobacteria among geochemical factors ferric oxide correlated increased microbial diversity silico analysis detected genes involved carbon nitrogen methane metabolism complex metabolic pathways responsible survival bacterial community nutrient limited cave environments present study paired end illumina sequencing along bioinformatics analysis revealed essential ecological role cave bacterial communities results useful documenting biospeleology region systematic understanding bacterial communities natural sediment environments well
background biomarkers metastatic castration resistant prostatic cancer mcrpc unmet medical need methods prognostic predictive value survival response salvage hormonal therapy sht baseline testosterone level analysed cohort mcrpc patients participating non hormonal first line chemotherapy phase iii trials inclusion criteria trials required results median age years visceral metastases median prostate specific antigen psa median median overall survival months significantly longer baseline high low median value months respectively hazard ratio presence anaemia unfavourable prognostic factor median months patients presenting anaemia low testosterone worse outcome compared one none median months high low associated psa response rate patients receiving sht conclusion testosterone level castration range prognostic factor survival mcrpc patients psa response sht differed depending tls testosterone levels might help treatment decision
background bipolar disorder major psychiatric disorder characterized alternating mood episodes including major depressive hypomanic manic episodes previous genetic studies reported several genes potentially associated ank gene identified possible susceptibility gene genome wide association analyses aims goal present study evaluate association ank variants korean population methods based previous results two single nucleotide polymorphisms snps selected ank gene study included patients healthy controls case control association case control haplotype analyses two ank variants performed results significant association found either single snp case control association analysis however showed significant association overall permutation case control haplotype analysis conclusions haplotype analysis results suggest ank variants may confer susceptibility korean population association analysis revealed probable genetic difference korean caucasian populations degree ank involvement pathogenesis
background bipolar disorder chronic illness year recurrence rate approximately among individuals receiving treatment community aim month open label continuation study evaluate long term safety effectiveness lurasidone patients initially presented major depressive episode associated bipolar disorder completed least months initial treatment lurasidone methods patients bipolar depression enrolled one three week double blind placebo controlled trials monotherapy lurasidone study adjunctive therapy lurasidone lithium valproate studies study completers eligible month open label extension study lurasidone utilizing flexible daily doses extension completers eligible additional months continuation treatment flexible daily doses lurasidone range concomitant therapy mood stabilizers permitted throughout open label extension continuation studies results total patients entered completed initial double blind acute treatment entered completed month extension study patients entered month continuation study discontinued including due adverse events due insufficient efficacy mean dose lurasidone month continuation study day modal dose day mean change weight acute baseline month continuation endpoint completers median changes cholesterol triglycerides respectively based kaplan meier analysis probability relapse months continuation treatment lurasidone estimated monotherapy group adjunctive therapy group improvement global illness severity also maintained months continuation therapy cgi continuation baseline month completers locf endpoint conclusions years treatment lurasidone safe well tolerated bipolar disorder population presenting index episode depression improvement depressive symptoms maintained majority patients treated lurasidone relatively low rates relapse minimal effects weight metabolic parameters
background bipolar disorder often associated lifetime indication treatment psychotropic drugs thus pregnant women face dilemma whether continue treatment study describes psychopharmacological drug utilization patterns among women bipolar disorder months preconception months postpartum methods conducted register based cohort study among danish women aged diagnosis bipolar disorder gave birth first singleton child january december psychotropic drug use determined prescriptions obtained danish national prescription registry results identified women proportion women redeeming prescriptions psychotropic drug decreased pregnancy months preconception third trimester lithium dosing increased significantly pregnancy total women psychotropic monotherapy women psychotropic polypharmacy used antidepressant without concomitant use mood stabilizer time pregnancy limitations redemption prescriptions assessable thus able assess compliance discontinuation treatment end treatment duration information drug use hospitalizations conclusions found decrease proportion women redeeming prescriptions pregnancy high prevalence antidepressant use without mood stabilizer potentially putting women risk switch mania although still debated calls investigation
background body composition prediction equations using skinfolds useful alternatives advanced techniques utility across diverse paediatric populations unknown aim evaluate published new prediction equations across diverse samples children health conditions affecting growth body composition subjects methods anthropometric dual energy ray absorptiometry dxa body composition measures obtained children syndrome crohn disease steroid sensitive nephrotic syndrome healthy reference group published body composition equations evaluated new equations developed ages years using healthy reference sample validated groups national survey data results fat mass fat free mass ffm percentage body fat published equations highly correlated dxa derived measures poor agreement mean difference ffm new equations produced similar correlations improved agreement reference group ffm respectively sub groups conclusions new body composition prediction equations show excellent agreement dxa improve body composition estimation healthy children selected conditions affecting growth
background bone morphogenetic protein bmp proven regulate white adipogensis aimed demonstrate correlation bmp fat distribution exenatide treatment methods enrolled obese patients anthropometric metabolic indexes collected fat distribution measured dual energy ray absorptiometry bpm levels assessed using enzyme link immunosorbent assay kit obese patients treated exenatide twice day change body weight metabolic related indices bpm levels evaluated weeks results mean bmp levels obese bpm levels significantly positively correlated estimated visceral adipose tissue mass subjects also females respectively bpm levels also significantly positively correlated body mass index hip circumference total fat females respectively bpm levels negatively correlated total cholesterol subjects males also respectively bpm levels also significantly positively correlated free triiodothyronine males multivariate analyses showed risk factor bmp concentration males est vat area risk factor bmp levels females bmp levels significantly higher obesity slightly increased thyroid stimulating hormone tsh obesity without slightly increased tsh exenatide treatment leads significant decreased bmp independent weight loss conclusion bmp levels associated visceral adipose tissue may play certain role fat distribution subclinical hypothyroidism obesity exenatide treatment reduced bmp levels independent weight loss
background bowel dysfunction including slow transit constipation defecatory dysfunction frequent often troubling nonmotor manifestation parkinson disease variety agents employed treatment constipation dissatisfaction available treatment approaches common relamorelin synthetic ghrelin agonist demonstrated prokinetic properties within gastrointestinal tract methods carried multi center randomized double blind placebo controlled study relamorelin patients experiencing chronic inadequately controlled constipation results intended subjects completed trial part unexpected occurrence multiple partially complete bowel movements constipated patients made many subjects ineligible participation conclusions although recruitment goals met precluded demonstration potential beneficial effect relamorelin unique important insights regard nature constipation recognized hopefully lead effective clinical trials future clear patients understand constipation may complex previously realized appear characterized decreased stool frequency alone elsevier ltd rights reserved
background boys autism spectrum disorder asd lower areal bone mineral density abmd typically developing controls tdc studies volumetric bmd vbmd bone microarchitecture provide information fracture risk beyond provided abmd currently lacking asd objectives assess ultradistal radius distal tibia vbmd bone microarchitecture strength estimates adolescent boys asd compared tdc design methods cross sectional study boys asd tdc assessed abmd whole body less head wblh hip spine using dual ray absorptiometry dxa vbmd bone microarchitecture ultradistal radius distal tibia using high resolution peripheral quantitative hrpqct iii bone strength estimates stiffness failure load using micro finite element analysis fea controlled age groupwise comparisons hrpqct fea measures activity questionnaires food records physical exam fasting levels vitamin bone markers terminal collagen crosslinks terminal telopeptide ctx ntx bone resorption terminal propeptide type procollagen pnp bone formation obtained results asd participants slightly younger tdc participants years tanner stage height scores fasting serum bone marker levels differ groups asd participants higher bmi scores percent body fat igf scores lower lean mass abmd scores tdc wblh femoral neck radius asd participants lower trabecular thickness compressive stiffness failure load tdc asd participants also smaller cortical area thickness compared tdc tibia asd participants lower compressive stiffness failure load smaller cortical area compared tdc lower proportion asd participants categorized physically active differences physical activity calcium intake igf responsiveness may contribute group differences stiffness failure load conclusion bone microarchitectural parameters impaired asd reductions bone strength estimates stiffness failure load ultradistal radius distal tibia may result lower physical activity calcium intake decreased igf responsiveness elsevier inc rights reserved
background brain mitogen activated protein kinase mapk potential therapeutic target cognitive dysfunction based neuroinflammation synaptic dysfunction cycle pathophysiology progression offers innovative pharmacological strategy via inhibiting activated target glia neurons thereby enhancing possibility efficacy highly selective brain penetrant pamapk inhibitor attenuates cognitive dysfunction two distinct alzheimer disease relevant models avoids problems encountered previous mixed kinase inhibitor drug candidates therefore essential glial effects cns active kinase inhibitor addressed order anticipate future use clinical investigations methods explored effects glial biology relevant app knock mouse model previously showed efficacy suppression hippocampal dependent associative spatial memory deficits day administered daily month old mice days levels proinflammatory cytokines beta tnfa measured homogenates mouse cortex using elisa glial markers iba gfap assessed immunohistochemistry microglia amyloid plaques quantified immunofluorescence staining followed confocal imaging levels soluble insoluble beta beta measured elisa studies vivo pharmacodynamic effects markers neuroinflammation complemented mechanistic studies murine microglia cell line using live cell imaging techniques monitor proliferation migration phagocytosis activities results intervention mice established therapeutic time window attenuated increased levels beta tnfa treatment also increased iba microglia within radius amyloid plaques without significantly affecting overall microglia plaque volume levels iba gfap beta beta affected treatment significantly alter microglial migration proliferation phagocytosis cells conclusions results demonstrate efficacious dose selectively modulate neuroinflammatory responses associated pathology progression without pan suppression normal physiological functions microglia
background breast fibromatosis rare disease characterized monoclonal fibroblast proliferation ability metastasize high local recurrence rate often infiltrates surrounding tissues surgical treatment reference recently new targeted therapies emerged report original case patient breast fibromatosis received exclusive medical treatment aim analyze treatments based clinical radiological outcome iatrogenic effects pharmacological action case presentation report case year old woman developed desmoid type fibromatosis lower inner quadrant right breast measuring volume initial surgery possible potential esthetic functional prejudice thus exclusive medical treatment including several lines nsaids tamoxifen triptorelin followed sorafenib interferon finally sunitinib tyrosine kinase inhibitors tkis sunitinib significant partial response observed reduction maximal tumoral volume treatment provided clinical radiological outcome association known pharmacological action conclusions tki interesting alternative option initial surgery providing least partial response potentially allowing less mutilating surgery however pharmacological mechanism unequivocally explain tki efficacy general breast fibromatosis treated along oncologist interventional radiologists trans disciplinary modality thus offering adapted treatment particular desmoid type fibromatosis localization
background bright light intervention reported successfully treat depression particular seasonal affective disorder neural pathways molecular mechanisms mediating effects unclear amygdala prefrontal cortex corticolimbic circuit regulates responses salient environmental stimuli threat may underlie effects serotonin signaling modulates circuit implicated pathophysiology seasonal affective disorders methods evaluated effects bright light intervention protocol threat related corticolimbic reactivity functional coupling assessed emotional faces functional magnetic resonance imaging paradigm preintervention postintervention double blind study conducted winter healthy male subjects received bright light intervention dose range participants kilolux minutes daily period weeks additionally considered serotonin transporter linked polymorphic region httlpr genotype status model differences serotonin signaling moderator intervention effects results bright light dose significantly negatively affected threat related amygdala prefrontal reactivity dose dependent manner conversely amygdala prefrontal intraprefrontal functional coupling increased significantly dose dependent manner genotype status significantly moderated bright light intervention effects intraprefrontal functional coupling conclusions first study evaluate effects clinically relevant bright light intervention threat related brain function show amygdala prefrontal reactivity communication significantly affected bright light intervention effect partly moderated genotype novel findings support threat related corticolimbic circuit sensitive light intervention may mediate therapeutic effects bright light intervention
background bupropion used treat depression pregnancy however usefulness smoking cessation aid pregnant women fully known objective objective study evaluate preliminary efficacy bupropion sustained release smoking cessation pregnancy study design conducted randomized prospective double blind placebo controlled pilot trial pregnant women smoked daily received individualized behavior counseling randomly assigned week twice day treatment bupropion sustained release placebo primary study objectives determine whether bupropion sustained release reduces nicotine withdrawal symptoms quit date treatment period compared placebo whether increases day point prevalence abstinence end treatment period end pregnancy results subjects bupropion placebo groups comparable age smoking history number daily smoked cigarettes nicotine dependence controlling maternal age race bupropion sustained release reduced cigarette cravings total nicotine withdrawal symptoms treatment period administration bupropion sustained release reduced tobacco exposure determined levels carbon monoxide exhaled air concentrations cotinine urine increased overall abstinence rates treatment however significant difference day point prevalence abstinence rates groups end medication treatment end pregnancy conclusion individual smoking cessation counseling along twice daily use bupropion sustained release increased smoking cessation rates reduced cravings total nicotine withdrawal symptoms treatment period however significant difference abstinence rates groups end medication treatment end pregnancy likely small sample size larger study needed confirm findings examine potential benefit risk ratio bupropion sustained release smoking cessation pregnancy
background time clinical symptoms alzheimer disease manifest patients already substantial tau pathology brain recent evidence also suggests tau pathology become self propagating accelerating disease progression last decade several groups tested efficacy protein based anti tau immunotherapeutics various animal models tauopathy report immunological therapeutic potency first anti tau dna vaccine based multitep platform thy tau transgenic mice methods starting months age mice immunized intramuscularly vaccine targeting tau cell epitope spanning followed electroporation humoral cellular immune responses vaccinated animals analyzed elisa elispot respectively neuropathological changes brains experimental control mice analyzed biochemical elisa immunohistochemical ihc methods months age results mediated vaccinations thy tau mice induced activation cells specific multitep vaccine platform triggered robust humoral immunity response specific tau importantly activation potentially harmful autoreactive cell responses specific endogenous tau species detected maximum titers anti tau antibodies reached two immunizations remained slightly lower steady five subsequent monthly immunizations vaccinations followed significantly reduced total tau phosphorylated tau levels brains extracts vaccinated mice produced subtle non significant effects phosphorylated tau species conclusions data demonstrate multitep based dna epitope vaccination targeting terminus tau highly immunogenic therapeutically potent thy tau mouse model tauopathy indicate mediated dna immunization attractive alternative protein based adjuvanted vaccines inducing high concentrations anti tau antibodies elsevier ltd rights reserved
background calprotectin mrp leukocyte derived proteins interleukin vascular endothelial growth factor vegf markers inflammation angiogenesis ultrasound sensitive detection greyscale synovitis power doppler vascularization objective present study explore associations calprotectin vegf erythrocyte sedimentation rate reactive protein comprehensive assessment patients rheumatoid arthritis starting biologic disease modifying anti rheumatic drug bdmard treatment methods total patients assessed clinical examination biomarker levels baseline months initiation bdmards assessment joints tendon sheaths scored semi quantitatively scale european league rheumatism eular response calculated statistical assessments performed explore associations biomarkers sum scores included spearman rank correlation analysis well linear linear mixed model regression analyses results calprotectin showed overall strongest correlations sum scores swollen joint counts examinations association sum scores remained adjusted age sex disease duration markers regression analysis baseline decreased calprotectin first month predictive eular response decreased sum scores months conclusions calprotectin highest association synovitis predicted treatment response may thus considered marker evaluating inflammation responsiveness patients bdmard treatment
background candidemia third leading cause morbidity mortality preterm low birth weight infants incidence risk factors candidemia population poorly known western china methods case control retrospective study candidemia conducted january november liuzhou maternity child healthcare hospital data analyzed univariate analysis multivariate logistic regression results forty eight confirmed cases candidemia identified study period indicating incidence per admissions low birth weight infants candida albicans common pathogen isolated infants candidemia mortality rate case group versus control group multivariable logistic regression model identified carbapenem use odds ratio confidence interval total parenteral nutrition prolonged hospitalization associated risk developing neonatal candidemia conclusion low birth weight infants significantly high risk developing candidemia local neonatal intensive care unit management teams effectively focus decreasing overall use carbapenems improving catheter care removing catheters early shortening hospitalizations reduce incidence candidemia association professionals infection control epidemiology inc published elsevier inc rights reserved
background cardiac catheterization often required patients extracorporeal membranous oxygenation ecmo support though efficacy remains unclear study aimed assess impact catheterization successful ecmo weaning methods single center retrospective study patients congenital heart disease underwent cardiac catheterization cardiac ecmo support included logistic regression analysis kaplan meier survival analysis log rank test performed determine predictors successful weaning patient outcome results forty nine catheterizations patients median age days range day years median body weight range included median duration ecmo cannulation catheterization day range days thirty three patients succeeded decannulation patients survived hospital discharge absence renal respiratory complications significant prognostic factors successful weaning multivariate analysis patients received catheterization within ecmo cannulation demonstrated less respiratory complications better survival days ecmo initiation underwent later catheterization mortality however nine major catheterization related complications detected conclusion catheterization pediatric patients ecmo support performed although group contained high risk serious adverse events absence ecmo complications predictor successful weaning earlier catheterization appears associated better short term survival cohort wiley periodicals inc
background cardiac rehabilitation one widely recommended strategies reduce burden cardiovascular disease multicomponent nature cardiac rehabilitation programs requires multidisciplinary team healthcare professionals including nurses equipped extensive knowledge skills however lack comprehensive explicit career pathway contains academic clinical development prepare nurses become cardiac rehabilitation specialists objective aim study identify essential components cardiac rehabilitation professionals educational preparation role responsibility competency inform framework career development cardiac rehabilitation nurses methods scoping review stages methodological framework scoping review arksey malley int soc methodol used results attempts made developing frameworks career development cardiac rehabilitation professionals components guidelines standards core curriculum development worldwide among united states country well established system including guidelines cardiac rehabilitation secondary prevention programs position statement terms competencies certification examination cardiac rehabilitation professionals nevertheless development integration efforts specifically cardiac rehabilitation nurses required conclusions vital raise awareness significant contribution appropriately educated trained nurses make reducing global burden cardiovascular disease cardiac rehabilitation therefore action establishing system comprehensive clearly defined career development pathway cardiac rehabilitation nurses worldwide immediate priority
background cardiomyocyte apoptosis common pathological manifestation occurs several heart diseases study aimed explore mechanism microrna mir cardiomyocyte apoptosis interfering activated bcl associated mitochondrial pathway methods mir mimics inhibitors transfected primary cardiomyocytes suckling sprague dawley rat pups used induce apoptosis flow cytometry tunel used detect cardiomyocyte apoptosis relative mrna transcript protein levels mir bbc bcl cleaved caspase detected using pcr western blot analysis respectively results mir overexpression significantly decreased expressions bbc cleaved caspase bcl expression significantly increased turn caused significant decrease rate cardiomyocyte apoptosis contrast mir silencing resulted elevated rate cardiomyocyte apoptosis conclusion mir may regulate cardiomyocyte apoptosis via mediated bcl associated mitochondrial apoptotic pathway therefore regulating mir expression cardiomyocytes effectively reduce activation bcl associated mitochondrial apoptotic pathway consequently protecting cardiomyocytes
background care women babies time birth sensitive measure functionality health system engaging communities preventing newborn deaths promising strategy achieve progress child survival sub saharan africa objective assess effect home visit strategy combined health facility strengthening uptake newborn care seeking practices services link results national policy scale uganda design uganda newborn study unest two arm cluster randomised controlled trial rural eastern uganda intervention villages volunteer community health workers chws trained identify pregnant women make five home visits two pregnancy three first week birth offer preventive promotive care counselling extra visits sick small newborns assess refer health facility strengthening done facilities improve quality care primary outcomes coverage key essential newborn care behaviours breastfeeding thermal care cord care analyses intention treat study registered clinical trial number isrctn results intervention significantly improved essential newborn care practices although many interventions saw major increases arms study period immediate breastfeeding birth exclusive breastfeeding significantly higher intervention arm compared control arm respectively skin skin care immediately birth cord cutting clean instrument marginally higher intervention arm versus control arm respectively half mothers intervention arm waited hours bathe baby compared control arm dry umbilical cord care also significantly higher intervention areas difference care seeking newborn illness high around arms skilled attendance delivery increased intervention control arms baseline endline significant difference coverage across arms endline home visits pro poor women poorest quintile visited chw compared families least poor quintile women delivered home visited chwafter birth compared delivered hospital health facility chws visited women newborns first week birth receiving visit critical first day life conclusions consistent results community newborn care studies volunteer chws effective changing long standing practices around newborn care home visit strategy may provide greater benefit poorer families however chw strategies require strong linkages concurrent improvement quality health system strengthening especially settings high increasing demand facility based services
background cavernous hemangiomas common benign vascular malformations existence intraventricular region rare case reports year old woman occipital headache admitted emergency ward brain computed tomography scan showed mild hydrocephalus multiple intraventricular isodense lesions imaging findings especially gradient resonance echo imaging favor multiple intraventricular cavernous malformations conclusion rare presentation multiple cavernous malformation occipital headache without needing surgical intervention phase coexistence periventricular plaques like radiologically isolated syndrome multiple sclerosis another unique aspect report
background childhood maltreatment potent predictor poor mental health across life span argue need improve understanding mechanisms confer psychiatric vulnerability following maltreatment progress simply treating manifest disorder developing effective preventative approaches help offset likelihood disorders emerge first place methods review extant functional neuroimaging studies children adolescents exposed early neglect maltreatment including physical sexual emotional abuse across four neurocognitive domains threat processing reward processing emotion regulation executive control findings discussed context latent vulnerability alterations neurocognitive function considered carry adaptive value early adverse caregiving environments confer long term risk results studies threat processing indicate heightened well depressed neural responsiveness maltreated samples particularly amygdala thought reflect threat hypervigilance avoidance respectively studies reward processing generally report blunted neural response anticipation receipt rewards particularly striatum patterns associated depressive symptomatology studies emotion regulation report increased activation anterior cingulate cortex acc active emotion regulation possibly reflecting greater effortful processing finally studies executive control report increased dorsal acc activity error monitoring inhibition conclusions emerging body work indicates altered neurocognitive functioning following maltreatment evident even absence overt psychopathology consistent perturbations seen individuals presenting psychiatric disorder predict future psychiatric symptomatology findings suggest maltreatment leads neurocognitive alterations embed latent vulnerability psychiatric disorder establishing compelling case identifying children risk developing mechanistically informed models preventative intervention interventions aim offset likelihood future psychiatric disorder
background childhood pneumonia one leading single causes mortality morbidity children worldwide etiology still remains unclear objective investigate association childhood pneumonia exposure diurnal temperature variation dtv different timing windows methods conducted prospective cohort study children aged years changsha china lifetime prevalence pneumonia assessed questionnaire administered parents individual exposure dtv prenatal postnatal periods estimated logic regression models used examine association childhood pneumonia dtv exposure terms odds ratios confidence interval results lifetime prevalence childhood pneumonia preschool children changsha high found childhood pneumonia significantly associated prenatal dtv exposure adjusted particularly second trimester however childhood pneumonia associated postnatal dtv exposure sensitivity analysis indicated boys susceptible pneumonia risk diurnal temperature variation girls observed prevalence childhood pneumonia decreased recent years dtv shrinked conclusions early childhood pneumonia associated prenatal exposure diurnal temperature variation dtv pregnancy particularly second trimester suggests fetal origin childhood pneumonia
background children reactive attachment disorder rad serious socio behavioral problems often rely socially abnormal aggressive manipulative forms communication little known however influence teachers socio behavioral development children symptoms rad aims longitudinal study examined influence teacher sensitivity socio behavioral development children symptoms rad across one school year method sample included belgian children teachers special education schools previous school year teachers rated inhibited disinhibited rad symptoms next school year teacher sensitivity observed interactions individual children first trimester teacher rated overt aggression relational aggression prosocial behavior assessed first second third trimester results found effects sensitivity prosocial behavior also effects found children disinhibited rad symptoms children inhibited rad symptoms increases overt relational aggression observed sensitivity low whereas decreases observed sensitivity high conclusions implications results suggest teacher sensitivity associated socio behavioral development children inhibited rad symptoms socio behavioral development children disinhibited rad symptoms paper adds children reactive attachment disorder rad exhibit socio behavioral problems hinder school adjustment socio behavioral problems appear relatively stable known influence special education teachers might development problems across school year study suggests teacher sensitivity associated changes socio behavioral development children inhibited rad symptoms whereas high sensitivity associated improvements low sensitivity appeared exaggerate socio behavioral problems children children inhibited rad symptoms difficulties communicating needs wishes socially adaptive ways may easy teachers understand children teachers may misinterpret child behavior consequently fail respond child underlying needs may reinforce child socio behavioral problems increase child reliance egocentric aggressive means interactions others study therefore highlights need support teachers interactions children inhibited rad symptoms order help understand children observable behaviors classroom may convey underlying socio emotional needs respond needs importantly teacher sensitivity associated socio behavioral development children disinhibited rad symptoms indiscriminate friendliness consistent previous research study suggests children inhibited rad symptoms susceptible quality caregiving environment children disinhibited rad symptoms extends finding school context elsevier ltd rights reserved
background china large population children years age whose health great concern chinese health care system however studies conducted analyze factors associated children unnecessary health care utilization china objective study provide empirical evidence issue investigating role parental health care utilization children unnecessary health care use methods data obtained fifth health service survey shaanxi province employed three dependent variables measure children health care utilization number children outpatient visits past weeks whether infusion used child outpatient visits past weeks number children inpatient visits last year based specific characteristics outcome variables negative binomial models used non negative numbers outpatient inpatient visits probit model used zero one indicator variable showing whether infusion used outpatient visits results based sample children results multivariate analysis showed children whose parents used outpatient care estimated larger number outpatient visits whose parents outpatient visits past weeks difference visits among children outpatient visits last weeks probability obtaining infusion percentage points higher children whose parents used infusion past weeks probability whose parents use infusion predicted number inpatient visits higher children whose parents used inpatient services last year compared group whose parents use difference visits moreover noted positive association parental children health care use prominent among younger children conclusions chinese children whose parents high health care users likely overuse health care services holding factors constant parents play important role reducing children unnecessary outpatient visits infusion use inpatient visits results suggest interventions aimed affecting patterns parental use may helpful improving appropriate health care utilization children
background chiropractic manipulation popular treatment neck pain headache may increase risk cervical artery dissection stroke patients carotid artery dissection present neck pain headache experiencing stroke common symptoms seen chiropractors primary care physicians pcps aimed assess risk carotid artery stroke chiropractic care comparing association chiropractic pcp visits subsequent stroke methods population based case crossover study undertaken ontario canada incident cases carotid artery stroke admitted hospitals year period identified cases served controls exposures chiropractic pcp services determined health billing records results compared cases control periods using exposure windows days prior stroke positive associations found chiropractic pcp visits subsequent stroke patients less years age associations tended increase analyses limited visits neck pain headache related diagnoses significant difference chiropractic pcp risk estimates found association chiropractic visits stroke years age older conclusions found excess risk carotid artery stroke chiropractic care associations chiropractic pcp visits stroke similar likely due patients early dissection related symptoms seeking care prior developing strokes
background chronic alcohol intake impacts skin directly organ dysfunction modifying preexisting dermatoses however dermatoses afflicting chronic alcoholics figure studies aim study aims correlate spectrum dermatoses chronic alcoholics quantum duration alcohol intake raised liver transaminases materials methods adult males totaling ascertained fulfill royal college psychiatry criteria chronic alcoholism addiction center referred dermatological consult enrolled cases similar number age sex matched teetotallers controls data emanating detailed history clinical examination routine liver functions tests summarized subsequently analyzed including statistically using chi square independent spearman rank correlation tests compared data previous studies results majority drank units alcohol week since mean years generalized pruritus odds ratio xerosis seborrheic dermatitis significantly common cases controls infections eczemas generalized hyperpigmentation major presenting complaints spider nevi gynecomastia pellagroid dermatitis present respectively exclusively cases commonly seen systemic abnormalities alcoholic liver disease diabetes mellitus peripheral neuropathy conclusion knowledge cutaneous manifestations chronic alcoholism could prompt depth history taking alcohol intake lead specialist referral thereby enable timely addiction hopefully serious adversities chronic alcoholics
background chronic hcv patients taking peg ifn alpha different ethnic groups different probabilities reaching sustained viral response svr many influence factors hcv genotype single nucleotide polymorphisms snp fibrosis index fib aspartate aminotransferase platelet ratio index apri score baseline factors relation treatment outcome still much clear methods evaluated data chronic hcv patients without liver fibrosis antiviral efficacy treatment pegylated interferon plus ribavirin peg ifn alpha weeks snp hcv genotypes analyzed genome sequencing using pyrosequencing results sustained viral response svr rates patients hcv genotypes addition apri hcv patients hcv patients could obtain svr conclusions high proportion hcv genotype northwest china hcv genotypes patients protective genotype likely obtain svr however significant fibrosis cirrhosis less likely matter genotype combined factors hcv genotype genotype fib arpi may indicate high prediction clinical value regarding treatment peg ifn alpha prognostic evaluation chronic hepatitis patients
background chronic immune diseases asthma highly prevalent currently available pharmaceuticals improve symptoms cure disease prompted demands alternatives pharmaceuticals probiotics prevention allergic disease however clinical trials produced inconsistent results least partly explained highly complex crosstalk among probiotic bacteria host microbiota immune cells identification bioactive substance probiotic bacteria could circumvent difficulty objective sought identify characterize bioactive probiotic metabolite potential prevention allergic airway disease methods probiotic supernatants screened ability concordantly decrease constitutive ccl secretion human hodgkin lymphoma cell line prevent upregulation costimulatory molecules lps stimulated human dendritic cells results supernatants tested probiotic strains showed immunoactivity bioassay guided chromatographic fractionation supernatants according polarity followed total ion chromatography mass spectrometry yielded chno molecular formula bioactive substance proton nuclear magnetic resonance enantiomeric separation identified tryptophan contrast tryptophan amino acids inactive feeding tryptophan mice experimental asthma induction increased numbers lung gut regulatory cells decreased lung responses ameliorated allergic airway inflammation hyperresponsiveness allergic airway inflammation reduced gut microbial diversity increased tryptophan conclusions tryptophan newly identified product probiotic bacteria findings support concept defined bacterial products exploited novel preventative strategies chronic immune diseases
background chronic migraine disabling condition worsened associated medication overuse mindfulness emerging technique effective different pain conditions yet explored report results study assessing one year course patients status hypothesis effectiveness mindfulness based approach would similar conventional prophylactic treatments methods patients code international classification headache disorders beta completed withdrawal program day hospital setting withdrawal patients either treated prophylactic medications med group participated mindfulness based training group consisted weekly sessions guided mindfulness patients invited practice min per day headache diaries headache impact test hit migraine disability assessment midas state trait anxiety stai beck depression inventory bdi administered withdrawal follow withdrawal patients groups outcome variables analyzed separate two way mixed anovas group mindfulness pharmacology time baseline month follow results total patients participated study average age average headache frequency month average monthly medication intake pills data revealed similar improvement time groups headache frequency approximately days reduction use medication approximately intakes reduction midas hit med group bdi changes state trait anxiety found groups revealed significant equivalent improvement respect become classical endpoint area research reduction headaches compared baseline majority patients condition longer satisfied current criteria conclusions taken whole results suggest longitudinal course patients group prescribed medical prophylaxis substantially similar patients administered medical prophylaxis
background chronic stress shown associated disease link direct also indirect harmful health behavior smoking changing eating habits recent mhealth trend offers new promising approach support adoption maintenance appropriate stress management techniques however studies dealt inclusion evidence based content within stress management apps mobile phones objective aim study evaluate stress management apps basis new taxonomy effective emotion focused stress management techniques established taxonomy behavior change techniques methods two trained independent raters evaluated free apps found google play regard behavior change emotion focused stress management techniques october results apps included average behavior change techniques emotion focused stress management techniques behavior change technique score stress management technique score highly correlated conclusions broad variation different stress management strategies found sample apps goes line found conventional stress management interventions self help literature moreover study provided first step toward detailed standardized taxonomies used investigate evidence based content stress management interventions enable greater comparability different intervention types
background chronic subdural hematoma csdh spinal anesthesia rare complication experienced patient developed csdh postdural puncture headache pdph following combined spinal epidural anesthesia cse case presentation week gestation parturient history previous cesarean delivery underwent elective cesarean section cse receiving aspirin therapy kawasaki disease many years developed symptom pdph day surgery fluid administration analgesics started although headache relatively severe persistent suddenly disappeared third postoperative day aspirin administration restarted third postoperative day patient discharged week surgery weeks discharged readmitted hospital severe headache diagnosed csdh epidural blood patch performed resulting resolution hematoma conclusions experienced case csdh pdph patient receiving aspirin therapy aspirin therapy restarted confirmation absence headache consider possibility unexpected disappearance pdph postoperative period may due development csdh
background circadian theories major depressive disorder suggested rhythm circadian pacemaker misaligned stable phase relationships internal rhythms temperature rest activity external day night cycle considered crucial adapting life external environmental therefore relationship possible alterations among light exposure activity rhythm iii temperature rhythm could important factors clinical depression study aimed investigate rhythmic alterations depression evaluate ability chronobiological parameters discriminate healthy subjects depressed patients methods thirty female subjects including healthy subjects depressed patients first episode major recurrent depression patients symptoms assessed using hamilton depression scale beck depression inventory montgomery asberg scale motor activity temperature light values determined days actigraph circadian rhythms calculated results depressed groups showed lower amplitude circadian rhythm activity light exposure higher amplitude rhythm peripheral temperature correlation temperature activity values different day night among control depressed groups level activity depressed patients lowest temperature values day amplitudes temperature activity highest discriminant parameters conclusions results indicate study rhythms useful diagnosis therapy depressive mood disorders
background classical thyroid hormones established necessary role normal development central nervous system recently considered decisive factors influencing cognitive functions adult brain involved development alzheimer disease picture summarizing thyroid hormone effects adult brain however include classical thyroid hormones also products peripheral metabolism latter considered inactive breakdown products long recently proved produce significant biological effects objective review article presented recent evidence supporting hypothesis thyroid hormones exert neuroprotective effect brain areas involved learning memory moreover summarized evidence suggests non classical thyroid hormones produce significant neurological effects adult brain also discussed possible role thyroid hormones cognitive impairment typical alzheimer disease methods comprehensive review literature based current knowledge effects classical non classical thyroid hormones adult brain role alzheimer disease performed results available literature suggests classical non classical thyroid hormones act neuroprotective agents brain areas related learning memory role areas supports idea may involved development alzheimer disease conclusion thyroid hormones produce significant neurological effects act neuroprotective agents might considered future diagnostic therapeutic tools alzheimer disease
background climacteric associated depression metabolic dysregulation scarce evidence suggests metabolic dysregulation may predict poor response conventional antidepressants response depression treatment studied homeopathic medicine aim study investigate prevalence metabolic disorders depressed climacteric women treated homeopathic medicines fluoxetine placebo alterations association response depression treatment methods one hundred thirty three mexican women years depression enrolled homdep menop study randomized placebo controlled double blind double dummy three arm trial week follow underwent complete medical history clinical examination metabolic parameters assessed baseline association baseline metabolic parameters response depression treatment analyzed bivariate analysis three groups odds ratios confidence interval calculated metabolic parameters considered inclusion logistic regression model statistically significant relationship response rate bivariate analysis clinically relevant results overall combined prevalence obesity overweight hypertriglyceridemia hypercholesterolemia insulin resistance subclinical hypothyroidism statistically significant association dyslipidemia overweight insulin resistance non response homeopathy group respectively conclusion metabolic dysregulation significantly associated response depression treatment depressed climacteric women treated individualized homeopathic treatment iht fluoxetine placebo due high prevalence metabolic disorders relationship depression climacteric investigation focused whether individualized prescriptions based classical homeopathy depressed climacteric women effect metabolic parameters treating metabolic disorders time could lead higher response rates
background coagulation abnormalities involved pathogenesis acute exacerbations idiopathic pulmonary fibrosis ipf administration recombinant human soluble thrombomodulin rhtm anti inflammatory anticoagulant activities improves outcomes respiratory function patients acute respiratory distress syndrome therefore conducted prospective clinical study examine effects rhtm respiratory function coagulation markers outcomes patients ipf methods registration protocol patients ipf satisfied study inclusion criteria treated daily rhtm days steroid pulse therapy concomitant administration immunosuppressants polymyxin immobilized fiber column treatment prohibited sample size subjects primary study outcome improvement pao fio ratio week treatment initiation secondary outcomes change dimer level time day survival rate patients without intubation study data compared historical untreated comparison group including patients ipf treated without rhtm registration results mean pao fio ratio rhtm treatment group day significantly improved compared day one two way analysis variance mean dimer level tended decrease rhtm group day change significant day survival rate higher rhtm group historical untreated comparison group difference significant post hoc analysis showed overall survival time significantly longer treated group compared historical untreated comparison group log rank test conclusion rhtm plus steroid pulse therapy improves respiratory functions patients ipf expected improve overall patient survival without using combination therapies
background cognitive impairment diagnosed magnetic resonance imaging mri functional magnetic resonance imaging fmri paradigms immediate delayed memory task dmt detect varying degrees working memory preliminary findings using dmt showed differences blood oxygenation level dependent bold activation impaired msci non impaired msni multiple sclerosis patients objectives aim study confirm detection based dmt bold activation larger cohort patients role lesion volume expanded disability status scale edss magnitude bold signal also sought methods total patients edss mean disease duration years age years underwent minimal assessment cognitive function multiple sclerosis macfims dmt working memory activation wma represents bold signal dmt minus signal imt based macfims results total msni msci borderline patients included analyses analysis variance anova showed msni significantly greater wma msci left prefrontal cortex left supplementary motor area regression analysis showed significant inverse correlations wma edss similar areas respectively conclusion dmt based bold activation detects larger studies needed confirm findings
background colitis exacerbated patients concurrent cytomegalovirus cmv infection inflammatory bowel disease ibd assessed prevalence clinical features cmv colitis hospitalized ibd patients methods retrospective study reviewed data january december compiled national taiwan university hospital cmv colitis patients demographic data clinical information treatment regimens pathologic findings outcome analyzed results total ibd patients hospitalized study period patients diagnosed crohn disease ulcerative colitis cmv colitis diagnosed positive inclusion bodies colonic tissue six patients five patients diagnosed cmv colitis compared patients without cmv colitis patients cmv colitis often older higher steroid usage noted cmv positive group compared age gender matched cmv negative ibd patients eight patients received ganciclovir treatment three patients receive antiviral treatment colitis flare ups index admission conclusions prevalence cmv colitis hospitalized ibd inpatients taiwan two associated factors cmv colitis hospitalized ibd patients elderly higher doses steroids routine histopathology studies pcr refractory colitis patients suggested diagnose cmv colitis diagnosis made antiviral treatment recommended decrease colitis relapse rate
background compared ischemic stroke sex differences response intracerebral hemorrhage ich largely unexplored potential interactions patient age examined study hypothesized risk poor outcome greater women increasing age methods results get guidelines stroke database used assess differences men women ich data ich patients admitted january march fully participating sites analyzed using logistic regression test interactions age sex outcome results total study population women median age male median age admission women years less likely atrial fibrillation dyslipidemia use antiplatelet therapy cholesterol reducers likely suffer worse neurological deficit men age increased odds hospital mortality increased men women although relationship stronger men odds combined mortality discharge hospice similar men women increasing age odds discharge home independent ambulation discharge decreased women increasing age conclusions adjusting covariates modest sex differences early outcomes ich linked age statistically significant detected interactions considered context future study may examine whether sex based interactions represent biologic treatment differences unmeasured covariates combination thereof
background computational analysis protein protein interaction provided crucial information increase binding affinity without change basic conformation several docking programs used predict near native poses protein protein complex top rankings universal criteria discriminating near native pose available since several classes recognition protein currently explicit criteria identifying near native pose ankyrin protein complexes apks reported yet results study established ensemble computational model discriminating near native docking pose apks named ankplex dataset apks generated seven ray apks consisted internal domains using reliable docking tool zdock dataset composed near native non near native poses respectively used generate eleven informative features subsequently scoring rank generated ankplex using combination decision tree algorithm logistic regression ankplex achieved superior efficiency near native complexes top rankings nine ray complexes compared zdock obtained six ray complexes addition feature analysis demonstrated van der waals feature dominant near native pose potential ankyrin protein docking poses conclusion ankplex model achieved success predicting near native docking poses led discovery informative characteristics could improve understanding ankyrin protein complex computational study could useful predicting near native poses binding proteins desired targets especially ankyrin protein complexes ankplex web server freely accessible http ankplex ams cmu
background congenital hypothyroidism common endocrine diseases one major causes preventable mental retardation study conducted investigate prevalence transient permanent congenital hypothyroidism kurdistan province iran materials methods cross sectional study registered congenital hypothyroidism neonate health centers cities covered kurdistan university medical sciences entered study demographic laboratory information neonates collected entered stata analyzed using student test chi square statistic value less considered results overall incidence rate province respectively per neonates period number diagnosed patients cases including boys girls cases urban areas total patients permanent significant difference gender location type childbirth season birth transient permanent types disease significant statistical relationship consanguineous marriages congenital hypothyroidism conclusion prevalence congenital hypothyroidism kurdistan province significantly higher global country levels emphasize continuation reinforcement screening program infants therefore complementary studies research priorities health system kurdistan province order clarify environmental genetic factors related
background controlled attenuation parameter cap liver stiffness measured transient elastography fibroscan used steatosis fibrosis assessment evaluated effect meal intake cap values methods forty patients liver biopsy within previous month recruited biopsy graded fibrosis steatosis stagings performed overnight fasting baseline values min following intake standard commercial formula meal every min cap values returned baseline effect meal intake cap values analyzed multilevel mixed model approach results mean age years old mean bmi fibrosis stages found respectively steatosis stages seen respectively mean cap median iqr values baseline kpa significant decrease cap values observed patients min meals cap peak value min mean post meal delta reduction min cap values declined meals early fibrosis stages across stages steatosis significant increase values meal intake observed within min peak value min mean post meal delta increase kpa post meal cap values returned baseline within min following meals conclusion following meal patients cap values declined peak value min contrasting rising values peak value min post meal cap values returned baseline min fasting period min meal recommended patients undergoing
background converging evidence suggests subjective cognitive concerns scc associated biomarker evidence alzheimer disease prior objective clinical impairment however sensitivity scc reports early may biased demographic factors sought investigate whether age education sex influence relationship scc amyloid beta burden methods cross sectional study examined clinically normal individuals females enrolled harvard aging brain study ages years mean years education mean scc assessed composite score comprising three questionnaires cortical beta burden assessed pittsburgh compound positron emission tomography imaging series linear regression models assessed potential modifying role demographic variables respect beta burden scc post hoc mediation model implemented understand relationship beta burden scc via relationship education results age beta sex beta modify relationship scc beta burden fewer years education correlated greater scc relationship beta burden scc stronger education beta partial mediation effect found beta burden scc via education
background cough variant asthma cva cough predominant asthma cpa major causes persistent cough japan utility fractional exhaled nitric oxide feno measurement differential diagnosis persistent cough reported influence atopic status associated higher feno levels diagnostic utility feno unknown methods retrospectively analyzed non smoking patients prolonged chronic cough treated corticosteroids anti leukotrienes results cpa diagnosed patients cva non asthmatic cough nac feno levels significantly higher cpa ppb cva ppb groups nac group ppb kruskal wallis test optimal cut distinguishing asthmatic cough cpa cva nac ppb area curve auc ppb meanwhile patients feno levels ppb stratified cut levels ppb auc atopic subjects ppb auc non atopic subjects auc conclusions although high feno levels suggested existence lower feno levels limited diagnostic significance atopic status affects utility feno levels differential diagnosis prolonged chronic cough copyright japanese society allergology production hosting elsevier
background craniovertebral junction complex anatomical location posing unique challenges surgical management pathologies aimed identify fifty cited articles dedicated field methods keyword search using thomson reuters web knowledge conducted identify articles relevant field craniovertebral junction surgery articles reviewed based title abstract methods necessary ranked based total number citations identify fifty cited articles characteristics articles determined analyzed results earliest top cited article published stratified decade productive articles cited article anderson dalonzo classification odontoid fractures citation rate cited article herms melcher described goel technique atlantoaxial fixation using lateral mass screws pedicle screws rod fixation atlantoaxial fixation common topic united states barrow neurological institute sonntag represented country institute author respectively significant majority articles designed case series providing level evidence conclusion using citation analysis provided list cited articles representing important contributions various authors many institutions across world field craniovertebral junction surgery
background data biological samples medical evaluations plays essential part clinical decision making data equally important clinical studies critical infrastructure ensures quality preserved throughout entire lifetime running year longitudinal clinical study kol orestad objective identify new copd chronic obstructive pulmonary disease biomarkers blood study clinical data blood samples collected private public health care institutions stored research center databases biobanks respectively blood analyzed mass spectrometry results analysis linked clinical data method built infrastructure allows efficiently collect analyze data chose use redcap edc electronic data capture tool study due short setup time ease use flexibility redcap allows users easily design data collection modules based existing templates addition provides two functions allow users import batches data web api application programming interface well uploading csv files comma separated values results created software dart data rapid translation translates biomarker data format fits redcap csv templates addition dart configurable work many data formats well use dart import clinical chemistry data redcap database conclusion shown powerful internationally adopted edc tool redcap extended used efficiently proteomic studies study accomplish using dart translate clinical chemistry data format fits templates redcap
background davallia formosana hayata herb used chinese medicine treat bone diseases including arthritis bone fractures osteoporosis rhizome formosana found rich epicatechin beta allopyranoside ecap considered active component plant terms antiosteoporotic effect study investigated molecular mechanism antiosteoporotic property ecap isolated roots formosana using vitro vivo models methods studied effects ecap signaling pathways receptor activator nuclear factor kappa ligand rankl stimulated osteoclastogenesis ovariectomy induced osteoporosis vitro study inhibitory action ecap rankl induced osteoclastogenesis expression osteoclast related marker genes investigated vivo study effects ecap bone evaluated using ovariectomized ovx mice orally administered ecap weeks results demonstrated ecap dose dependently inhibited rankl nuclear factor activated cells cytoplasmic nfatc induced osteoclastogenesis raw cells reduced extent bone resorption furthermore images trap staining showed oral administration ecap ovx mice prevented bone loss ecap administration also exerted recovery effects serum terminal telopeptide type collagen osteocalcin levels ovx mice addition also found mmp expression decreased vivo vitro conclusions overall findings suggested ecap suppresses rankl induced osteoclastogenesis kappa nfatc signaling pathways potential use osteoporosis treatment
background daylight hours high latitude regions tend longer japan summer shorter japan winter example daylight hours london winter one third tokyo therefore study investigated compared seasonal changes mood behaviours japanese individuals living outside japan methods surveys conducted japanese residents summer winter nordic countries southeast asia japan first summer winter general health questionnaire ghq scores regional group analysed subsequently month wise differences mood behaviours compared across four geographical regions results summer winter ghq scores participants living nordic countries differed significantly seasonal differences observed residents japan southeast asia nordic countries summer associated better mood activity winter linked lowered mood reduced activity conclusion results indicate japanese living nordic countries high latitude regions experience seasonal fluctuations depressive symptoms may linked drastic seasonal environmental changes observed month period mood behaviour declined winter improved summer therefore considering prevalence overseas stressors differ home country necessary investigate effectiveness support systems help migrants adapt seasonal changes high latitude regions
background default mode network dmn vulnerable effects apoe genotype given reduced brain volumes apoe epsilon related brain changes elderly carriers less known whether changes would influence functional connectivity extent study aimed examine functional connectivity within dmn diagnostic value age related morphometric alterations considered methods whole brain seed based resting state functional connectivity rsfc analysis conducted cognitively normal apoe epsilon carriers matched non carriers absolute values mean correlation coefficients values used measure functional connectivity strength fcs dmn subregions also used estimate diagnostic value receiver operating characteristic roc curves results apoe epsilon carriers demonstrated decreased interhemispheric fcs particularly right hippocampal formation left inferior parietal lobular ipl roc analysis showed fcs ipl could differentiate apoe epsilon carriers healthy counterparts auc value moreover adjusting impact morphometry differentiated value fcs ipl markedly improved auc value conclusions findings suggest apoe epsilon allele affects functional connectivity within posterior dmn particularly atrophy corrected interhemispheric fcs clinical expression neurodegenerative disease
background dementia common end stage renal disease esrd patients hemodialysis associated worse outcomes study aimed investigate risk major adverse cardiac cerebrovascular event macce elderly patients dementia initiating methods using database health insurance review assessment service analyzed patients aged years older initiated dialysis macce defined composite outcome cause mortality nonfatal acute myocardial infarction target vessel revascularization nonfatal ischemic hemorrhagic stroke kaplan meier method cox proportional hazards model used comparisons using propensity score matching ratio also performed results total elderly patients dementia initiating follow dementia significant predictor macce adjustment confounding variables addition analyzed propensity score matched groups dementia independent predictor nonfatal ischemic stroke cause mortality conclusions dementia independent risk factor mortality ischemic stroke elderly esrd patients initiating patients dementia start dialysis closely monitored reduce risk mortality ischemic stroke
background designing evidence based interventions address socioeconomic disparities health health behaviours requires better understanding specific explanatory mechanisms aimed investigate comprehensive range potential theoretical mediators physical activity screen time different socioeconomic status ses groups high ses group high school students low ses group vocational school students com system including theoretical domains framework tdf used heuristic framework synthesise different theoretical determinants exploratory study methods finnish vocational high school students aged responded survey assessing psychological social environmental determinants activity screen time determinants mappable com domains capability opportunity motivation outcome measures validated self report measures screen time statistical analyses included bootstrapping based mediation procedure results regarding ses differences com domains example vocational school students reported using less self monitoring weaker injunctive norms engage regular fewer intentions high school students mediation analyses identified potential mediators ses relationship three domains important candidates included self monitoring identity material resources available however ses related determinants screentime mainly gender differences determinants similarly related behaviours ses groups indicating major moderation effect ses relationships conclusions study revealed already first years educational differentiation levels key determinants differ contributing socioeconomic differences analyses identified strongest mediators ses association additional investigation utilising longitudinal experimental designs needed study demonstrates usefulness combining constructs various theoretical approaches better understand role distinct mechanisms underpin socioeconomic health behaviour disparities
background despite considerable progress treatment post traumatic stress disorder ptsd large percentage individuals remain symptomatic following gold standard therapies one route improving care examining affective disturbances involve emotions beyond fear threat growing body research implicated shame ptsd development course although date review specific literature exists scoping review investigated link shame ptsd sought identify research gaps methods systematic database search pubmed psycinfo embase cochrane cinahl conducted find original quantitative research related shame ptsd results forty seven studies met inclusion criteria review found substantial support association shame ptsd well preliminary evidence suggesting utility treatment target several design limitations investigated areas recognized including need multimodal assessment shame longitudinal treatment focused research conclusion review provides crucial synthesis research date highlighting prominence shame ptsd likely relevance successful treatment outcomes present review serves guide future work critical area study
background despite links early relational experiences psychopathology data regarding childhood emotional neglect among canadian mental health services users scarce aims explore absence emotional support experiences reported canadian psychiatric outpatients examine relationship childhood emotional support borderline personality disorder bpd features methods survey regarding childhood emotional support completed consecutively admitted adult outpatients along self report assessments symptom distress bpd features results substantial proportion outpatients reported absent emotional support experiences controlling effects age symptom distress childhood emotional support found significantly negatively associated bpd features conclusion findings add support need clinical attention early relational experiences mental health service users
background despite importance coping caregiving studies relationship coping quality life caregivers frail dependent elderly thus study aims analyze relationship coping strategies quality life dimensions primary caregivers dependent elderly relatives methods cross sectional study conducted caregivers predictive variables coping strategies problem focused emotion focused socially supported dysfunctional dependent variables quality life dimensions psychological physical relational environmental potential confounding variables age gender perceived health burden caregiver functional capacity care receiver correlation coefficients calculated multiple linear regression analysis performed results controlling potential confounders dysfunctional coping related worse quality life psychological dimension emotion focused socially supported coping related superior psychological environmental dimensions quality life physical relational dimensions quality life related coping strategies conclusions important consider coping strategies assessment primary caregivers dependent elderly relatives quality life caregivers related coping strategies quality life worsened avoidance type coping quality life improved active emotion focused coping socially supported coping
background determination hepatitis virus hcv genotype discrimination hcv subtypes still mandatory prior anti hcv treatment initiation aim study evaluate performance recently introduced cobas hcv assay roche compare two comparator assays methods cobas hcv assay based primerspecific real time polymerase chain reaction pcr comparison trugene hcv genotyping kit siemens versant hcv genotype assay siemens employed accuracy new assay determined using proficiency panels clinical evaluation residual clinical samples obtained patients chronic hepatitis infection included results accuracy tested panel members containing hcv subtypes identified expected however new assay failed identify low titer panel members containing hcv subtype correctly clinical samples gave concordant results seven samples indeterminate result reported cobas hcv assay remaining samples found discordant one comparator assays time results assays compared new assay showed shorter total time similar handson time per sample conclusions cobas hcv assay showed good performance proved suitable use routine diagnostic laboratory due high level automation fast reliable results obtained short hands time
background dfn novel intranasal spray formulation composed sumatriptan permeation enhancing excipient comprised dodecyl beta maltopyranoside ddm composition dfn allows sumatriptan rapidly absorbed systemic circulation exhibit pharmacokinetics comparable subcutaneously administered sumatriptan rapid rate absorption suggested important optimal efficacy objective study evaluate safety tolerability dfn acute treatment episodic migraine without aura month period based incidence treatment emergent adverse events evaluation results clinical laboratory tests vital signs physical examination electrocardiograms methods multi center open label repeat dose safety study adults episodic migraine without aura subjects diagnosed migraine without aura according criteria set forth international classification headache disorders edition experienced attacks per month fewer headache days per month least headache free hours attacks used dfn treat migraine attacks acutely course months results total subjects enrolled subjects used least dose study medication evaluable safety subjects completed month study total migraine attacks reported doses dfn administered mean per subject monthly use dfn doses adverse events expected triptans well nasally administered compounds new safety signals emerged dysgeusia application site pain commonly reported treatment emergent adverse events months respectively treatment emergent adverse events mild serious adverse events considered unrelated study medication early discontinuation rate month treatment period conclusion dfn shown well tolerated used months treat episodic migraine acutely
background diabetes become challenging health priority globally given tensions financially burdened health systems europe mobilisation community resources like voluntary organisations community groups seen health policy strategy sustain management long term conditions like diabetes however little known happening practice europe objectives explore diabetes self management interventions undertaken promoted voluntary organisations community groups europe describe types working relationships organisations european health systems users implementing diabetes self management programmes different areas design mixed method study survey qualitative interviews undertaken research formed part european project framework programme european commission exploring link resources like community organisations peoples capacities manage long term conditions settings six european countries bulgaria greece norway spain netherlands united kingdom participated study three areas deprived urban area relatively affluent urban area deprived rural area purposefully selected participants purposeful sample bottom strategies representatives voluntary organisations community groups recruited geographical areas organisations least three members existing least one year could provide information type support directly indirectly relevant patients diabetes included methods participants completed item questionnaire survey voice recorded semi structured interview data collection focused type activities roles developed promote health relationships communication channels organisations health services users descriptive comparative statistical qualitative content analyses used results participants perceived better reach people health needs health providers filled administration gaps left capacity deal basic diabetes practical needs humanized care acted mediators services communities significant differences countries relation types activities value roles value funding sources value organisations concerning diabetes self management non affluent countries organisations tend promote social activities twice often conclusions community voluntary organisations provide complimentary going support diabetes management involves shift focusing illness also longing social cohesion sense community wellbeing diabetes health practices policies authors published elsevier ltd open access article license http creativecommons org licenses
background diagnosis syphilis difficult follow therapy evaluation syphilitic patients poor little known positron emission tomography pet syphilis review systematically review usefulness pet diagnosis disease extent evaluation follow treatment response assessment patients syphilis methods searched pubmed embase scopus cochrane library web science clinicaltrials gov three chinese databases sinomed wanfang cnki english chinese language articles inception september also collected potentially relevant studies reviews using manual search search keywords included combined text mesh terms syphilis positron emission tomography included studies reporting syphilis pet scan antibiotic treatment diagnosis syphilis based serological criteria dark field microscopy outcomes include pre post treatment pet scan pre post treatment computed tomography pre post treatment magnetic resonance imaging excluded articles published english chinese involving humans results identified articles observational studies included thirty three studies single patient case reports one study small case series patients adults mean age patients years primary syphilis increased fluorodeoxyglucose fdg accumulation could seen site inoculation regional lymph nodes secondary syphilis lung bone gastrointestinal involvement generalized lymphadenopathy increased fdg uptake commonly detected changes tertiary syphilis increased glucose metabolic activity hypometabolic lesions normal glucose uptake might seen pet five types pet scans neurosyphilis repeated pet scan treatment revealed apparent complete resolution asymmetry radiotracer uptake conclusion pet helpful targeting diagnostic interventions characterizing disease extent assessing nodal involvement treatment efficacy syphilis
background diarrheal diseases one major causes mortality common health problems developing countries important role malnutrition children due effects diarrhea malnutrition improving diarrhea treatment programs important children health aim study evaluate effect vitamin improvement watery diarrhea years old children methods study performed children aged years affected acute watery diarrhea admitted shahidbeheshti hospital patients divided two groups vitamin group control group duration diarrhea average diarrheal episodes length hospitalization recorded data analyzed use chi squared tests findings study included patients two groups patients intervention group patients control group found average duration diarrhea group receiving vitamin significantly lower days intervention group days control group well diarrhea frequency respectively length hospitalization days intervention group days control group conclusion intramuscular vitamin prescription treatment diarrheal diseases children reduces duration severity diarrhea
background differentiation malignant benign liver tumors remains challenging problem recent years mass spectrometry technique emerged promising strategy diagnose wide range malignant tumors purpose study establish classification models distinguish benign malignant liver tumors identify liver cancer specific peptides mass spectrometry material methods study serum samples patients malignant liver tumors patients benign liver tumors treated weak cation exchange chromatography magnetic beads wcx kits analyzed matrix assisted laser desorption time flight mass spectrometry maldi tof established genetic algorithm supervised neural networks snn quick classifier models distinguish malignant benign liver tumors confirm clinical applicability established models blinded validation test performed clinical serum samples discriminatory peaks associated malignant liver tumors subsequently identified qtof synapt system results total discriminant peaks mass spectra serum samples found clinpro tools software recognition capabilities established models snn cross validation rates snn accuracy rates blinded validation test snn discriminatory peptide peaks analyzed peaks identified fragment fibrinogen alpha chain fibrinogen beta chain inter alpha trypsin inhibitor heavy chain itih respectively conclusions results demonstrated technique helpful differentiation benign malignant liver tumors fibrinogen itih might used biomarkers diagnosis malignant liver tumors
background difficulties diagnosis inflammatory bowel disease ibd motivate search new diagnostic tools including laboratory tests aim study evaluate concentrations neutrophil neu proteins leukocyte elastase hle alpha lactoferrin calprotectin potential biomarkers used diagnosis assessment clinical activity crohn disease ulcerative colitis material methods study included patients patients healthy controls plasma concentrations calprotectin lactoferrin hle alpha measured using elisa results patients higher concentrations hle alpha calprotectin lactoferrin control group found patients higher plasma concentrations hle alpha calprotectin lactoferrin control group found hle alpha neu lactoferrin neu ratios patients significantly higher compared patients calprotectin lactoferrin levels higher patients active compared inactive phase conclusions diagnostic characteristics plasma granulocyte protein concentrations indicate usefulness tests diagnosis ibd higher hle alpha lactoferrin neu ratios patients may suggest usefulness ratios differential diagnostics plasma calprotectin lactoferrin levels may useful activity assessment
background digital health interventions dhis including computer assisted therapy smartphone apps wearable technologies heralded enormous potential improve uptake accessibility efficiency clinical effectiveness personalisation mental health interventions generally assumed dhis preferred children young people cyp given ubiquitous digital activity however remains uncertain whether dhis cyp clinically cost effective cyp prefer dhis traditional services dhis widen access evaluated adopted mental health services review evaluates evidence base dhis considers key research questions approaches evaluation implementation methods conducted meta review scoping narrative systematic meta analytical reviews investigating effectiveness dhis mental health problems cyp also updated systematic review randomised controlled trials rcts dhis cyp published last years results twenty one reviews included meta review findings provide support clinical benefit dhis particularly computerised cognitive behavioural therapy ccbt depression anxiety adolescents young adults systematic review identified new rcts evaluating dhis attention deficit hyperactivity disorder adhd autism anxiety depression psychosis eating disorders ptsd benefits dhis managing adhd autism psychosis eating disorders uncertain evidence lacking regarding cost effectiveness dhis conclusions key methodological limitations make difficult draw definitive conclusions existing clinical trials dhis issues include variable uptake engagement dhis lack agreed typology taxonomy dhis small sample sizes lack blinded outcome assessment combining different comparators short term follow poor specification level human support research practice recommendations presented address key research questions methodological issues evaluation clinical implementation dhis cyp
background direct acting antivirals daas dramatically improve treatment hepatitis virus hcv infections however effects daas extra hepatic manifestations hcv associated glomerulonephritis especially cases renal dysfunction well elucidated case presentation year old japanese woman diagnosed chronic hepatitis genotype age presented hypertension microscopic hematuria proteinuria renal dysfunction purpura arthralgia age also hypocomplementemia cryoglobulinemia renal biopsy revealed membranoproliferative glomerulonephritis mpgn diagnosed hcv associated cryoglobulinemic mpgn declined interferon therapy time treated antihypertensive medications well oral corticosteroid effective reducing proteinuria however corticosteroid dose reduced proteinuria worsened began antiviral treatment daclatasvir asunaprevir dcv asv clearance hcv rna obtained weeks sustained liver function normalized addition microhematuria turned negative proteinuria decreased hypocomplementemia estimated glomerular filtration rate improved whereas cryoglobulinemia persisted completed weeks therapy without significant adverse effects conclusion case hcv associated cryoglobulinemic mpgn renal dysfunction dcv asv based daas ameliorated microhematuria proteinuria renal function without significant side effects
background disc golf sport played much like traditional golf rather using ball club players throw flying discs various throwing motions played estimated million people united states like sports injuries sustained playing disc golf uncommon although formalized grown rapid pace however disc golf related injuries yet described medical literature purpose describe common injuries incurred disc golf players comparing different types throwing styles study design descriptive epidemiology study methods data study collected disc golf players responded online survey collected month period respondents answered questions related demographics experience style play injury details using chi square analysis common injuries sustained players using backhand forehand throwing styles compared results respondents stated sustained injury playing disc golf including injuries elbow shoulder back knee injuries commonly described muscle strain sprain tendinitis type throw primarily used players varied using backhand using forehand using overhead throw players using forehand throw likely sustain elbow injury many players stated undergone surgery due disc golf related injury common surgeries including meniscal shoulder spine foot ankle surgeries conclusion majority surveyed disc golfers sustained least injury playing disc golf many requiring surgery types injuries sustained players varied types throw primarily used sport disc golf continues expand health professionals aware injuries sustained future studies focusing injury prevention education strategies
background diseases digestive system found contribute higher symptom burden older adults thus therapeutic strategies able treat gastrointestinal discomfort might impact overall health status help older adults increase overall health status optimal functionality objective aim double blinded randomized placebo controlled clinical trial evaluate effect probiotic strain lactobacillus reuteri digestive health wellbeing older adults methods study enrolled general older adults years eligibility screening qualified subjects participated arm study design arm consisting weeks intervention either active placebo product primary outcome measure set changes gastrointestinal symptoms secondary outcome measures changes level wellbeing anxiety stress follow performed weeks results persistent significant effects observed primary secondary outcome parameters study modest effect observed probiotic arm levels stress decreased week similarly found subjects suffering indigestion abdominal pain respectively showed significant decrease anxiety week probiotic treatment week conclusion rct failed show improvement digestive health daily intake probiotic supplement containing reuteri neither significant improvement wellbeing stress anxiety observed even though rct negative outcome study highlights issues important take consideration designing trials among older adults
background dna methylation important epigenetic mechanism involved gene regulation alterations dna methylation nuclear genome linked numerous complex diseases mitochondrial dna methylation phenomenon receiving ever increasing interest particularly diseases characterized mitochondrial dysfunction however studies limited investigation specific target regions analyses spanning entire mitochondrial genome limited potentially due amount input dna required mitochondrial genetic studies previously confounded nuclear mitochondrial pseudogenes methylated dna immunoprecipitation sequencing technique widely used profile dna methylation across nuclear genome however reads mapped mitochondrial dna often discarded developed approach control nuclear mitochondrial pseudogenes within methylated dna immunoprecipitation sequencing data highlight utility approach identifying differences mitochondrial dna methylation across regions human brain pre mortem blood results able correlate mitochondrial dna methylation patterns cortex cerebellum blood identified nominally significant differentially methylated regions mitochondrial genome anatomically separate cortical regions cerebellum matched samples matched donors analysis identified eight significant differentially methylated regions total cortex cerebellum correcting multiple testing using unsupervised hierarchical clustering analysis mitochondrial dna methylome able identify tissue specific patterns mitochondrial dna methylation blood cerebellum cortex conclusions study represents comprehensive analysis mitochondrial methylome using pre existing methylated dna immunoprecipitation sequencing data identify brain region specific patterns mitochondrial dna methylation
background docetaxel cytostatic agent approved treatment non small cell lung cancer well cancers although docetaxel effective cytostatic agent effectiveness clinical practice associated variety acute long term side effects overcome systemic side effects slow release formulation based calcium sulfate docetaxel intra tumoral administration developed methods two formulations calcium sulfate nanozolid technology generated twofold difference docetaxel drug load formulations injected intra tumorally paste solidified within tumor effects two intra tumoral injection formulations tested female mice inoculated subcutaneous lewis lung carcinoma cells two formulations compared systemic intraperitoneal injection docetaxel placebo formulation without docetaxel tumor volumes measured systemic side effects evaluated using body weight cell counts whole blood well plasma concentrations results docetaxel formulations showed significantly higher antitumor efficacy compared placebo comparable systemic administration docetaxel moreover intra tumoral formulations docetaxel showed reduced systemic toxicity compared systemic treatment including less weight loss decrease blood cell counts conclusions results suggest intra tumoral slow release calcium sulfate based formulations docetaxel alternative strategy efficient local antitumoral treatment reduced systemic toxicity elsevier rights reserved
background syndrome common chromosomal aberration characteristics brainstem component condition childhood newborn preteen stages clarified objective evaluate morphological features brainstem magnetic resonance imaging mri materials methods mris children boys girls age range years without major brain insults age matched controls boys girls retrospectively analyzed height width area midbrain pons medulla oblongata measured sagittal weighted images compared children age matched controls ratios brainstem size posterior fossa index calculated also compared children control group results width area midbrain height width area pons area medulla oblongata significantly smaller children control children area pons particularly ventral part showed largest differences mean relative differences indices height width area pons significantly smaller children control group however indices midbrain medulla oblongata differ two groups conclusions children may small brainstems particularly pons may characteristic morphological feature brainstem mri childhood including neonates japanese society child neurology published elsevier rights reserved
background dysregulation prostaglandin pge signaling pathway implicated interstitial pneumonia pathogenesis due unstable nature pge available detection methods may precisely reflect pge levels explored clinical usefulness measuring stable prostaglandin major urinary metabolite pge mum respect pathogenesis extent chronic fibrosing cfip including idiopathic pulmonary fibrosis ipf pge mum reflective systemic pge production methods pge mum measured radioimmunoassay controls patients lung diseases bronchial asthma chronic obstructive pulmonary disease copd cfip extent lung fibrosis assessed fibrosing score computed tomography immunohistochemical evaluation cox performed find pge producing cells ipf human bronchial epithelial cells hbec lung fibroblasts lfb used vitro experiments results compared control pge mum levels significantly elevated cfip pge mum levels positively correlated inversely correlated dlco cox highly expressed metaplastic epithelial cells ipf lower expression receptor demonstrated lfb derived ipf tgf beta induced cox expression hbec conclusions pge mum elevated cfip promising biomarker reflecting disease activity metaplastic epithelial cells source elevated pge mum ipf elsevier ltd rights reserved
background earlier studies shown absolute number neutrophil granulocytes ngs may increase attack hereditary angioedema due inhibitor deficiency inh hae whether ngs undergo activation attack yet investigated however neutrophil elastase cleave inactivate inh may contribute dysregulation kallikrein kinin system hence edema formation aim investigate possible activation ngs attacks methods studied blood samples obtained patients inh hae symptom free periods attacks along samples healthy volunteers count ngc myeloperoxidase mpo pentraxin ptx crp factor tnf alpha levels measured results ngc higher attacks symptom free periods observed mpo ptx levels strong positive correlation mpo levels attacks furthermore tnf alpha levels also elevated attacks compared symptom free periods contrast factor levels similar samples obtained attacks symptom free periods conclusion increased ngc associated elevated mpo levels suggests neutrophil activation attacks strong positive correlation mpo levels together elevated ptx concentration may indicate expression neutrophil extracellular traps processes may contribute activation kallikrein kinin system leads onset edematous episode
background early accurate prediction outcome acute stroke important aim prospective study explore correlation serum triiodothyronine level prognosis acute ischemic stroke patients methods prospective observational study included consecutive patients acute ischemic stroke december november interrogated serum triiodothyronine concentrations measured admission understand value predicting functional outcome within using multivariable models adjusted confounding factors receiver operating characteristic roc curves calculated define best cut value triiodothyronine predict outcome accuracy test assessed measuring area roc curve auroc results triiodothyronine significantly decreased patients unfavorable functional outcome compared patients favorable functional outcome within binary logistic regression analyses revealed lower triiodothyronine concentrations admission associated risk poor outcomes addition roc curve analysis triiodothyronine may improve national institutes health stroke scale nihss score predicting functional outcome combined model auroc significantly higher aurocs original nihss triiodothyronine age conclusions low serum triiodothyronine levels predictive marker short term outcome ischemic stroke combined model triiodothyronine age nihss score add significant additional predictive information clinical score nihss
background early life stress els addiction related age related diseases telomere shortening however role telomere length crack cocaine addiction remains unknown purpose study investigate sample crack cocaine dependent women reported els history community based sample elderly women reference group senescence methods study included treatment seeking crack cocaine dependents women elderly women without psychiatric diagnosis eld crack cocaine sample divided two groups according childhood trauma questionnaire ctq scores presence history childhood abuse neglect crack els absence els history crack assessed ratio obtained peripheral blood dna using quantitative pcr assay esults crack crack els subjects exhibited shortened comparison eld group despite younger age among crack cocaine sample crack els group significantly shorter telomeres crack group correlation analysis within crack cocaine group indicated negatively correlated emotional abuse scores conclusions results support previous findings associating telomere shortening els drug addiction study suggests new evidence distinct biological phenotype drug dependent women els results support biological senescence hypothesis underpinning els experience elsevier inc rights reserved
background early research documented young children show increased interest toward objects verbally labeled adult compared objects presented without label unclear whether phenomenon occurs neurodevelopmental disorders affecting social development autism spectrum disorder asd williams syndrome methods present study used novel eye tracking paradigm determine whether hearing verbal label increases salience novel objects preschoolers asd preschoolers typically developing peers results found typically developing children asd spent significantly time looking objects verbally labeled adult compared objects presented without label conclusions children without asd information accompanied speaker verbal label accorded special status likely attended contrast children asd appear attribute special salience labeled objects compared non labeled objects result consistent notion reduced responsivity pedagogical cues hinders social learning young children asd
background early stage lung cancer represents key focus numerous multicenter clinical trials common exclusion criteria prior cancer diagnosis may limit enrollment examined prevalence prognostic impact prior cancer diagnosis among patients early stage lung cancer methods identified patients years age early stage lung cancer diagnosed surveillance epidemiology end results medicare linked database prior cancers characterized type stage timing respect lung cancer diagnosis cause lung cancer specific survival rates compared patients without prior cancer using cox regression analyses propensity scores results among patients early stage lung cancer one fifth prior cancer common prior cancers prostate breast gastrointestinal genitourinary prior cancers localized diagnosed within years lung cancer diagnosis difference cause survival patients without prior cancer hazard ratio lung cancer specific survival improved among patients prior cancer conclusions prior cancer history may exclude substantial proportion patients early stage lung cancer enrollment clinical trials without adverse effect clinical outcomes inclusion patients age years prior cancer clinical trials considered improve study accrual completion rates generalizability
background ecallantide human plasma kallikrein inhibitor indicated treatment acute attacks hereditary angioedema patients years age older ecallantide produced pichia pastoris yeast cells recombinant dna technology use ecallantide associated risk hypersensitivity reactions including anaphylaxis objective objective detailed retrospective data review characterize anaphylaxis cases within ecallantide clinical trials database methods potential cases hypersensitivity reactions ecallantide clinical development program identified examining reported adverse events national institute allergy infectious disease criteria used identify events consistent anaphylaxis cases reviewed detail results investigational antibody testing also examined results among patients received subcutaneous ecallantide patients doses ecallantide patients reactions met national institute allergy infectious disease criteria anaphylaxis none occurred first exposure drug reactions symptom onset within hour exposure cutaneous manifestations commonly observed type hypersensitivity reactions reactions responded standard management type hypersensitivity reactions resolved without fatal outcomes ige antibody testing ecallantide pastoris consistently positive patients experienced apparent type hypersensitivity reactions conclusion anaphylaxis episodes subcutaneous ecallantide exposure clinical features suggestive type hypersensitivity reactions however anti ecallantide antie pastoris ige antibody status found reliably associated anaphylaxis authors published elsevier inc behalf american academy allergy asthma immunology
background education outside classroom eotc teaching method aims promote schoolchildren learning physical activity social relations motivation well eotc activities characterized teachers using local environment teaching involve innovative teaching methods child led approaches problem solving experimentation cooperation play eotc become common practice many teachers scandinavia however case studies evaluated impacts teachout study aims evaluate impacts eotc danish schoolchildren social relations motivation well learning methods teachout quasi experimental cross disciplinary study sixteen schools participated containing eotc school classes parallel non eotc classes total children aged years measures children social relations motivation school well academic performance collected beginning end school year data levels collected ten day periods school year using accelerometers amount characteristics actual eotc provided eotc non eotc classes monitored day day throughout school year using online teacher survey platform effects eotc mainly analysed comparing eotc pupils non eotc control pupils based scores outcome variables school performance well motivation social relations end school year adjusting baseline values beginning year impacts eotc evaluated comparing total well context specific amounts children participating eotc children parallel non eotc classes furthermore interdependencies social relations well motivation learning explored using path analysis help describe understand processes led quantitative outcomes qualitative case observations children practices interactions eotc well classroom teaching carried combined qualitative interviews children perceptions practices discussion teachout study represents holistic multidisciplinary approach educational school health promotion research study design combination scientific disciplines methods well focus interdependent relations learning social relations well motivation result comprehensive picture school health promotion children health well broaden understanding potential benefits eotc school health promotion primary education results used inform guide future policy practice
background efficacious well tolerated direct antiviral agents drastically changed prognosis hepatitis virus hcv disease real world data oral treatments limited key populations hiv hcv coinfection advanced liver disease daclatasvir dcv efficacy safety assessed french autorisation temporaire utilisation atu program providing dcv ahead market authorization patients advanced hcv disease without treatment options methods subanalysis hiv hcv coinfected atu patients treated dcv plus sofosbuvir sof recommended duration weeks addition ribavirin rbv shorter treatment physician discretion primary efficacy analysis sustained virologic response posttreatment week svr modified intention treat safety assessed spontaneous adverse event reporting results efficacy population mostly cirrhotic decompensated hcv treatment experienced infected genotypes median cells hiv rna copies treated weeks received rbv svr overall confidence interval patients cirrhosis patients without cirrhosis svr consistent across hcv genotypes antiretroviral regimens among patients safety data discontinued adverse event died conclusions dcv sof rbv achieved high svr well tolerated large real world cohort hiv hcv coinfected patients advanced liver disease
background ehealth literacy gaining importance maintaining promoting health studies found individuals high ehealth literacy likely adopt healthy eating exercise sleep behaviors addition previous studies shown various individual factors frequency seeking information health issues degree health concern frequency eating organic food students college major associated ehealth literacy health promoting lifestyles nevertheless studies explored associations among individual factors ehealth literacy health promoting lifestyles among college students moreover lack studies focus ehealth literacy predictor psychological health behaviors objective examine associations among various individual factors ehealth literacy health promoting lifestyles methods ehealth literacy scale item instrument designed measure college students functional interactive critical ehealth literacy health promoting lifestyle scale item instrument developed measure college students self actualization health responsibility interpersonal support exercise nutrition stress management nationally representative sample valid college students taiwan surveyed questionnaire administered gather respondents background information including frequency seeking information health issues frequency eating organic food degree health concern students major conducted multiple regression analysis examine associations among individual factors ehealth literacy health promoting lifestyles results study found factors medical majors greater concern health predicted college students health promoting lifestyle dimensions dimensions ehealth literacy moreover critical ehealth literacy positively predicted health promoting lifestyle dimensions functional literacy positively predicted dimensions interactive literacy predicted self actualization dimension conclusions study found participants majored medical fields greater concern health frequently sought health information exhibited better ehealth literacy positive health promoting lifestyle moreover study showed college students higher critical ehealth literacy engaged better health promoting activities functional interactive literacy
background eisenmenger syndrome associated substantial morbidity mortality consensus however mortality risk stratification aimed investigate survival predictors death large contemporary cohort eisenmenger syndrome patients methods multicenter approach identified adults eisenmenger syndrome follow examined survival association clinical electrocardiographic echocardiographic laboratory parameters results studied patients median age years range years female syndrome majority posttricuspid defect followed patients complex pretricuspid lesion median follow years interquartile range allowing patient years observation patients died underwent transplantation twelve parameters emerged significant predictors death univariable analysis multivariable cox regression analysis age hazard ratio years confidence interval pretricuspid shunt oxygen saturation rest presence sinus rhythm presence pericardial effusion remained significant predictors death conclusions significant premature mortality among contemporary adults eisenmenger syndrome report herewith multivariable mortality risk stratification model based simple noninvasive predictors death population
background elderly patients undergoing colorectal surgery increasingly become scrutiny accounting largest fraction geriatric postoperative deaths significant proportion postoperative complications including anastomotic leak objective study aimed determine predictors anastomotic leak elderly patients undergoing colectomy creating novel nomogram simplistic prediction anastomotic leak risk given patient design study retrospective review settings database review american college surgeons national surgical quality improvement program conducted single institution patients patients aged years underwent elective segmental colectomy anastomosis different levels abdominal low pelvic identified multi institutional procedure targeted database main outcome measures constructed stepwise multiple logistic regression model anastomotic leak outcome predictors selected stepwise fashion using akaike information criterion validity nomogram externally tested elderly patients years age american college surgeons national surgical quality improvement program colectomy targeted database results total patients analyzed anastomotic leak occurred patients developed anastomotic leak men based unadjusted analysis factors associated increased risk anastomotic leak asa score chronic obstructive pulmonary disease diabetes mellitus smoking history weight loss previously infected wound omitting mechanical bowel preparation preoperative oral antibiotic use wounds classified contaminated dirty infected patients developed anastomotic leak longer length hospital stay operative time min multivariate model nomogram created limitations study limited retrospective nature short term follow conclusions accurate prediction anastomotic leak affecting morbidity mortality colorectal surgery using proposed nomogram may facilitate decision making elderly patients healthcare providers
background emergency contraception refers contraceptive methods used sexual intercourse aim analyze evolution emergency contraception consultations chilean public health system communal level relation legal changes recently took place aimed ease delivery benefit analyze association socioeconomic demographic municipal healthcare system characteristics material methods analyzed data bases ministry health study consultation rates chilean communes including consultations emergency departments rape evaluated association communal characteristics obtained national municipal information system results communal consultation rates percentage communes consultations increased progressively period explosive increase observed high dispersion consultations communal regional level inverse significant association number consultations communal poverty rate conclusions results reveal impact legal modifications implemented chile since communal consultation rates hand results reveal although modifications oriented favor delivery benefit high dispersion subsists associated population socioeconomic factors mainly communal poverty level
background essential tremor exclusively tremor disorder also associated cognitive gait dysfunction however gap knowledge relationship cognitive gait dysfunction studied detail examined relationship cognition balance falls hypothesized cognitive dysfunction patients would associated greater problems balance falls methods cases recruited clinical pathological study cognition comprehensive cognitive assessment performed included montreal cognitive assessment moca measure global cognition multiple motor free tests comprehensively assessing performance cognitive domain assignment clinical dementia rating cdr scores collected data number reported falls past year balance confidence assessed using item activities balance confidence scale cross sectional analyses utilized baseline data results cases mean age years linear regression models considered effects numerous confounding variables lower global cognition poorer cognition associated greater number falls reduced balance confidence similar adjusted linear regression models higher cdr score poorer functional cognition associated greater number falls reduced balance confidence also assessed whether number falls balance confidence associated performance specific cognitive domains number falls closely linked performance tests executive function balance confidence executive function attention memory conclusion data indicate correlate poorer cognition greater number falls lower balance confidence cognition enter dialog patients issue clinical significance
background evidence extreme ambient temperature effects risk mental disorders mds limited study evaluated short term effects daily mean temperature hospital admissions mds shanghai china methods obtained daily hospital admission data mds daily meteorological ambient pollution data shanghai january december adjusted time trend air pollution relative humidity confounders quasi poisson generalized additive model gam combined distributed lag non linear model dlnm used analyze lag exposure response relationship daily mean temperature hospital admissions mds results total daily hospital admissions mds study period reference median temperature degrees significant positive association temperature threshold degrees hospital admission visits lag days relative risks extreme hot temperatures degrees percentile lag days compared median temperature confidence intervals effect cold weather hospital admissions mds observed conclusions study suggests extreme hot temperature poses significant risks health counseling cooling measures considered susceptible population elsevier rights reserved
background evidence linking prenatal exposure outdoor air pollution eczema early childhood scare role components air pollution exposure timing remains unclear objectives investigated association exposure air pollution preconceptional perinatal period risk eczema preschool children methods conducted prospective cohort study children aged years changsha china prevalence eczema assessed standardized health questionnaire administered parents individual exposures nitrogen dioxide sulfur dioxide particulate matter aerodynamic diameter month pregnancy entire pregnancy three trimesters estimated inverse distance weighted idw method based concentrations measured monitoring stations association childhood eczema exposure air pollution examined logistic regression models terms odds ratio confidence interval interquartile range iqr increase exposure results life time prevalence eczema preschool children changsha childhood eczema associated traffic related air pollutant months pregnancy entire pregnancy adjusted ors respectively highest risk eczema observed trimester exposure however association detected philio exposure window high level exposure whole time period significantly increased effect windows eczema risk compared low level exposure sensitivity analysis indicated association preconceptional perinatal exposure childhood eczema consistent robust association modified personal parental hereditary indoor environmental factors conclusion findings support hypothesis early childhood eczema associated exposure traffic related air pollutant preconceptional perinatal period especially high level exposure japanese society investigative dermatology published elsevier ireland ltd rights reserved
background exacerbations copd often accompanied pulmonary systemic inflammation associated increased susceptibility prevalence weight loss muscle wasting muscle mass loss disease exacerbations may contribute emphysema associated muscle atrophy however whether pulmonary inflammation presence emphysema differentially affects skeletal muscle including protein synthesis degradation signaling pathways previously addressed aims study develop mouse model disease exacerbation associated muscle wasting evaluate whether emphysema muscle wasting monitored non invasively assess alterations muscle protein turnover regulation methods emphysema induced three weekly intra tracheal elastase vehicle control instillations followed one single lps bolus instillation mimic pulmonary inflammation driven disease exacerbation consequently four experimental groups defined lps lps using micro cone beam scans emphysema development muscle mass changes monitored correlated muscle weight lps instillation protein turnover signaling assessed muscle tissue collected post lps instillation results micro imaging correlated strongly established invasive measurements emphysema muscle atrophy pulmonary inflammation following lps instillation developed irrespective emphysema body muscle weight similarly reduced groups accordingly mrna protein expression levels genes ubiquitin proteasome pathway ups autophagy lysosomal pathway alp upregulated skeletal muscle following lps contrast mtor signaling controls alp protein synthesis reduced pulmonary inflammation well emphysema single insult compared control conclusion changes lung tissue density muscle mass monitored non invasively evaluate emphysema muscle atrophy longitudinally acute loss muscle mass evoked pulmonary inflammation similar control emphysematous mice although muscle atrophy cues response pulmonary inflammation altered emphysema emphysema affects protein synthesis alp signaling may interfere muscle mass recovery impair maintenance muscle mass emphysema
background exposures prenatal period may lasting effects maternal child health outcomes better understand effects utero environment children short long term health large representative pregnancy cohorts comprehensive information broad range environmental influences including biological behavioral ability link prenatal child maternal health outcomes needed research program genes environment health rpgeh pregnancy cohort kaiser permanente northern california kpnc established create resource conducting research better understand factors influencing women children health recruitment integrated routine clinical prenatal care kpnc integrated health care delivery system detail study design data collection methodologies establishing cohort also describe baseline characteristics cohort representativeness underlying pregnant population kpnc methods recruitment ongoing october rpgeh pregnancy cohort included pregnancies racial ethnic minorities rpgeh pregnancy cohort participants consented blood samples obtained first trimester mean gestational age weeks second trimester mean gestational age weeks stored future use women invited complete questionnaire health history lifestyle information women clinical health assessments pregnancy women children health outcomes available health system electronic health records also allows long term follow discussion large racially ethnically diverse cohort pregnancies prenatal biospecimens clinical data valuable resource future studies utero environmental exposures maternal child perinatal long term health outcomes baseline characteristics rpgeh pregnancy cohort demonstrate highly representative underlying population living broader community northern california
background extensive backflow treated wastewater caused household water contamination finnish town drinking water residents became heavily polluted faecal microbes resulting large gastroenteritis epidemic cases reactive arthritis milder joint symptoms prolonged gastrointestinal symptoms observed outbreak follow survey performed study less familiar long term health consequences within year outbreak methods contaminated group comprised sample residents area polluted water supply control group sample residents nearby municipality presence general symptoms complaints inquired mail survey quarterly prevalence symptom complaint measured twelve proceeded analysis results response rate contaminated group control group rash eye irritation heartburn weight loss prevalent contaminated group first year quarter last year quarter eye irritation significantly common contaminated group conclusion excess prevalence four complaints first year quarter explained acute gastroenteritis intensive water chlorination excess prevalence eye irritation fourth year quarter explained chlorination anymore might sign existing reactive joint disease general long term consequences outbreak considered minor terms surveyed symptoms complaints
background familial pulmonary fibrosis fpf defined idiopathic diffuse parenchymal lung disease affecting two members primary biological family aim present study contribute clinical functional radiological characterisation fpf particular regards disease progression survival methods baseline clinical functional radiological data fpf population patients retrospectively collected analysed according ipf guidelines hrct classification pft follow year survival analysis conducted among different hrct patterns results female male patients age diagnosis years old belonging families included study radiological analysis demonstrated presence uip pattern hrct patients poss uip incon uip incon uip patients younger frequently female pulmonary function tests showed restrictive ventilatory defect patients uip incon uip patterns poss uip patients normal volumes mild reduction dlco bal composition revealed increased lymphocytes percentage incon uip patients respiratory functional year follow showed significant worsening uip patients hrct pattern progression demonstrated poss uip uip patients median survival statistically different among hrct groups although poss uip patients presented better outcome conclusions fpf confirmed complex condition poor prognosis present study firstly analysed functional radiological follow data patients fpf showing may manifests several hrct patterns different rates progression possible uip uip could considered phases disease inconsistent uip patients may represent different clinical radiological condition elsevier ltd rights reserved
background fatigue highly prevalent hematopoietic stem cell transplantation hct described intense may last years following treatment objective aim study compare fatigue physical activity sleep emotional distress cognitive function biological measures hct survivors persistent fatigue age gender matched healthy controls occasional tiredness methods data collected using objective real time assessments physical activity sleep days patient reported fatigue assessments computerized objective testing cognitive functioning biological measures differences groups examined using multivariate analysis variance results survivors hct reported increased physical mental overall fatigue well increased anxiety depression compared healthy controls red blood cell rbc levels significantly lower hct survivors levels rbc groups however normal range tumor necrosis factor interleukin levels significantly higher hct survivors conclusions persistent fatigue hct survivors compared healthy controls occasional tiredness accompanied increased anxiety depression along decreased rbc counts elevated tumor necrosis factor alpha interleukin levels may important biomarkers implications practice study provides preliminary support conceptualization fatigue existing continuum tiredness anchoring one end exhaustion persistent fatigue experienced hct survivors severe occasional tiredness everyday life
background feature selection methods commonly used identify subsets relevant features facilitate construction models classification yet little known feature selection methods perform diffusion tensor images dtis study feature selection machine learning classification methods tested purpose automating diagnosis migraines using dtis questionnaire answers related emotion cognition factors influence pain perceptions methods select adult subjects study divided three groups control group subjects sporadic migraine subjects chronic migraine medication overuse subjects underwent magnetic resonance diffusion tensor see white matter pathway integrity regions interest involved pain emotion tests also gather data pathology dti images test results introduced feature selection algorithms gradient tree boosting based random forest univariate reduce features first dataset classification algorithms svm support vector machine boosting adaboost naive bayes perform classification migraine group moreover implement committee method improve classification accuracy based feature selection algorithms results classifying migraine group greatest improvements accuracy made using proposed committee based feature selection method using approach accuracy classification three types improved using naive bayes classifier support vector machine classifier boosting features determined useful classification included related pain analgesics left uncinate brain connected pain emotions conclusions proposed feature selection committee method improved performance migraine diagnosis classifiers compared individual feature selection methods producing robust system achieved accuracy classifiers results suggest proposed methods used support specialists classification migraines patients undergoing magnetic resonance imaging
background female moths synthesize species specific sex pheromone components release attract male moths depend precise sex pheromone chemosensory system locate females two types genes involved sex pheromone biosynthesis degradation pathways play essential roles important moth behavior understand function genes sex pheromone pathway study investigated genome wide digital gene expression sex pheromone biosynthesis degradation genes various adult tissues diamondback moth dbm plutella xylostella notorious vegetable pest worldwide results massive transcriptome data least generated sequencing adult tissues including male antennae female antennae heads legs abdomen female pheromone glands dbm using illumina next generation sequencing mapping published dbm genome bioinformatics analysis yielded total unigenes among transcripts putatively related seven gene families sex pheromone biosynthesis pathway among seven two desaturases des three fatty acyl coa reductases far one acetyltransferase act one alcohol dehydrogenase mainly expressed pheromone glands likely function three essential sex pheromone biosynthesis steps desaturation reduction esterification also identified odorantdegradation related genes including sex pheromone degradation related genes seven major enzyme groups among genes genes new identified two aldehyde oxidases aoxs one aldehyde dehydrogenase aldh five carboxyl cholinesterases cces five udp glycosyltransferases ugts eight cytochrome cyp three glutathione transferases gsts displayed robust expression antennae thus proposed participate degradation sex pheromone components plant volatiles conclusions date comprehensive gene data set sex pheromone biosynthesis degradation enzyme related genes dbm created genome transcriptome wide identification characterization expression profiling findings provide basis better understand function genes tissue enriched expression results also provide information genes involved sex pheromone biosynthesis degradation may useful identify potential gene targets pest control strategies disrupting insect insect communication using pheromone based behavioral antagonists
background folate vitamin homocysteine concentrations pregnancy important factors early development may persistently influence kidney function offspring examined associations folate vitamin homocysteine concentrations pregnancy kidney outcomes school aged children study design population based prospective cohort study fetal life onward settings participants study performed among pregnant women children predictors folate vitamin homocysteine blood concentrations measured early pregnancy median gestational age iqr weeks birth cord blood outcomes measurements median age iqr years measured combined kidney volume ultrasound estimated glomerular filtration rate based creatinine egfr cystatin egfr cys concentrations microalbuminuria results observed higher maternal folate concentrations associated larger childhood combined kidney volume whereas higher maternal vitamin concentrations associated higher childhood egfr cys associations independent homocysteine concentrations higher maternal homocysteine concentrations associated smaller combined kidney volume lower childhood egfr cys association maternal homocysteine concentrations childhood egfr cys largely explained combined kidney volume higher cord blood homocysteine concentrations associated larger combined kidney volume lower egfr cys folate vitamin homocysteine concentrations associated microalbuminuria limitations observational study causality established conclusions findings suggest folate vitamin homocysteine concentrations fetal life associated offspring kidney development however effect sizes small studies replicate findings assess causality consequences kidney health later life needed national kidney foundation inc
background food fitness going multi component health promotion programme delivered primary secondary schools community nutrition assistants programme uses nutritional interventions aimed promoting healthier eating practices children service evaluation investigated receipt delivery programme perceived local stakeholders experienced administered service methods semi structured interviews focus groups carried three key stakeholder groups health professionals school teachers senior health officials qualitative data transcribed verbatim received thematic analysis deductive inductive processes results stakeholders reported programme contributed development food education healthy eating practices children local area stakeholders considered main concern limited capacity size service described problems long term sustainability supporting schools maintaining nutritional interventions highlighting issues regarding contact planning organisation several interventions conclusions findings service evaluation inform service management organisation ground level delivery use stakeholder opinion provided contextualised information factors impact implementation programme richness qualitative results guide future planning provision similar health promotion nutrition programmes delivered school environment
background gal ovomucoid dominant allergen chicken egg white hypoallergenic variants allergen used immunotherapy egg allergy treatment approach hypothesised disruption two nine cysteine cysteine bridges site directed mutagenesis allow production hypoallergenic variant protein methods two cysteine residues domain iii protein mutated alanine using site directed mutagenesis disrupt two separate cysteine cysteine bridges mutated non mutated proteins expressed escherichia coli coli induction isopropyl beta thiogalactopyranoside iptg expressed proteins analysed using sodium dodecyl sulfate polyacrylamide gel electrophoresis sds page immunoblotting confirm expression immunoglobulin ige reactivity two proteins analysed immunoblotting pool egg allergic patients sera pool non allergic patients sera also used separate blot negative control results mutant gal showed diminished ige reactivity immunoblot showing lighter bands compared non mutated version although mutant protein immobilised membrane compared wild type protein non allergic negative control showed bands indicating absence non specific binding secondary antibody proteins conclusion disruption two cysteine bridges domain iii gal reduces ige reactivity following downstream laboratory clinical testing mutant protein used immunotherapy induce tolerance gal egg allergy diagnosis
background gambling disorder previously known pathological gambling behavioural addiction included revised diagnostic statistical manual mental disorders dsm american psychiatric association chapter substance related addictive disorders often comorbid substance use disorder two disorders also common individuals impulsive personality including individuals antisocial personality disorder aspd research investigated association aspd identify risk factors traits thai methamphetamine dependent sample methods demographic diagnostic data based dsm american psychiatric association obtained methamphetamine dependent individuals using semi structured assessment drug dependence alcoholism ssadda part ongoing study genetics methamphetamine induced psychosis thai substance dependence treatment cohort associations aspd analyzed using chi square test risk factors aspd identified logistic regression analysis results comorbidity aspd methamphetamine dependence high respectively individuals aspd likely without chi demographic variable associated aspd male sex aspd youth age years predicted diagnosis aspd addition host substance dependence variables associated aspd including severe methamphetamine dependence aspd nicotine dependence aspd alcohol dependence aspd cannabis use associated opiate use occurrence methamphetamine induced paranoia conclusions risk factors common aspd gender substance dependence severity substance dependence aspd associated neuropsychiatric disorders methamphetamine dependent individuals age predictor diagnosis aspd suggesting pathophysiological differences basis substance dependence different age groups
background gastroesophageal reflux ger associated idiopathic pulmonary fibrosis ipf pathogenesis may related chronic micro aspiration aimed assess objective measures ger multichannel intraluminal impedance study mii relationship pulmonary function testing pft results compare performance acid reflux parameters corresponding mii bolus parameters predicting pulmonary dysfunction ipf methods retrospective cohort study ipf patients undergoing prelung transplant evaluation mii acid suppression received pft within months patients prior fundoplication excluded severe pulmonary dysfunction defined using diffusion capacity lung carbon monoxide dlco six acid reflux parameters corresponding mii bolus reflux measures specified priori multivariate analyses applied using forward stepwise logistic regression predictive value parameter severe pulmonary dysfunction calculated area receiver operating characteristic curve statistic key results forty five subjects age mild moderate severe met criteria inclusion patient demographics clinical characteristics similar pulmonary dysfunction groups abnormal total reflux episodes prolonged bolus clearance time significantly associated pulmonary dysfunction severity univariate multivariate analyses parameters significant statistic parameter lower mii counterpart predicting pulmonary dysfunction conclusions inferences mii bolus reflux acid reflux associated pulmonary dysfunction prelung transplant patients ipf mii may valuable testing alone characterizing ger ipf
background gastrointestinal dysfunction vein thrombosis well known acute complications spinal cord injuries scis objective determine frequency risk factors deep vein thrombosis dvt small intestinal bacterial overgrowth sibo patients sci methods total consecutive eligible sci patients tested sibo glucose hydrogen methane breath test january december also undergone venous ultrasound study suspected dvt evaluated within months admission results seventy six sci patients dvt positive confidence interval sibopositive among dvt positive patients sibo positive sibo negative difference statistically significant versus odds ratio among sibo positive patients dvt positive dvt negative difference statistically significant versus stepwise multivariate logistic regression family history venous thrombosis chronic kidney disease presence sibo remained associated dvt conclusions data support association sibo dvt sci patients studies carried respect relationship sibo dvt
background grasses poaceae one largest plant families distributed worldwide grass pollen allergy one important pollen allergies affecting large parts population worldwide grass pollen season special since caused flowering various grass species present unique profiles allergenicity assumingly plays significant role impact grass pollen sensitization profiles allergy sufferer aim study conducted vienna analyze possible contribution prevalent grass species grass pollen season symptom load grass allergy sufferers methods first study combines phenological observations grass species flowering periods aerobiological measurements daily grass pollen concentrations concert allergic symptoms local users patient hayfever diary symptom load index calculation results pollen concentrations symptom levels higher first half main grass pollen season therefore show highest impact pollen allergy sufferers important note following species widely distributed vienna kentucky bluegrass poa pratensis orchard grass dactylis glomerata false oat grass arrhenatherum elatius fescue grass festuca perennial rye grass lolium perenne conclusion monitoring different grass species provided evidence varying contribution pollination across main grass pollen season highlighted significance impact may pollen allergy sufferers elsevier rights reserved
background group cognitive behavior therapy gcbt effective treatment improving self management behaviors quality life asthmatic patients however mechanisms gcbt improves asthma related clinical symptoms remain unknown previous studies indicated insula important region involved neuropathology asthma therefore examined possible alteration functional connectivity insula subregions gcbt asthmatic patients methods forty two asthmatic patients healthy controls hcs received resting state functional magnetic resonance imaging fmri scan clinical assessments asthmatic patients completed gcbt treatment consisting sessions received fmri scan clinical assessments results asthmatic patients greater left ventral anterior insula vai left cerebellum posterior lobe right middle temporal gyrus bilateral anterior cingulate cortex acc less bilateral postcentral gyrus bilateral occipital lobe left precentral gyrus compared hcs left posterior insula left medial frontal gyrus also increased patients addition right vai showed increased right caudate left putamen right dorsal anterior insula dai left calcarine however decreased increase insula subregions significantly improved following gcbt left vai connectivity left postcentral gyrus positively correlated percentage improvement items hamilton depression rating scale scores right dai left calcarine negatively associated improvement percentage asthma control test scores conclusions study first time demonstrated gcbt led significant improvement insula subregions brain regions
background growing evidence points key role somatostatin sst schizophrenia bipolar disorder amygdala neurons expressing sst play important role regulation anxiety often comorbid disorders tested hypothesis sst immunoreactive neurons decreased amygdala subjects evidence circadian sst expression amygdala disrupted circadian rhythms rhythmic peaks anxiety suggest disruption rhythmic expression sst disorder methods amygdala sections control subjects processed immunocytochemistry sst neuropeptide neuropeptide partially coexpressed sst neurons total numbers neurons measured time death used test associations circadian rhythms results sst neurons decreased lateral amygdala nucleus normal control subjects sst neurons varied according time death pattern altered subjects characterized decreases sst neurons selectively subjects time death corresponding day numbers neuropeptide neurons affected conclusions decreased sst neurons amygdala patients interpreted decreased sst expression may disrupt responses fear anxiety regulation individuals findings raise possibility morning peaks anxiety depend disruption circadian regulation sst expression amygdala
background health service providers restrict access contraceptives imposed biases method appropriateness study provider biases toward contraceptive service provision among urban nigerian providers assessed methods health providers working health facilities well pharmacists patent medical vendors pmv abuja benin city ibadan ilorin kaduna zaria surveyed concerning self reported biases service provision based age parity marital status results minimum age bias common bias minimum parity least common bias reported providers condoms consistently provided least amount bias followed provision emergency contraception pills injectables iuds experience service training health facility providers associated decreased prevalence marital status bias pill injectable iud however training experience opposite effect pharmacists pmv operator reports service provision bias conclusions provider imposed eligibility barriers urban study sites nigeria pervasive prevalent restriction across method provider type minimum age given large growing adolescent population interventions aimed increasing supportive provision contraceptives youth context urgently needed results show effect service training provider biases limited future efforts address provider biases contraceptive service provision among provider types must find creative ways address critical barrier increased contraceptive use
background healthcare providers generate huge amount biomedical data stored either legacy system paper based format electronic medical records emr around world collectively referred big biomedical data bbd realize promise bbd clinical use research essential step extract key data elements unstructured medical records patient centered electronic health records computable data elements objective introduce novel solution known double reading entry system dress extracting clinical data unstructured medical records creating semi structured electronic health record database well demonstrate reproducibility empirically methods utilizing modern cloud based technologies developed comprehensive system includes multiple subsystems capturing mrs clinics securely transferring mrs storing managing cloud based mrs facilitating machine learning manual reading performing iterative quality control committing semi structured data desired database evaluate reproducibility extracted medical data elements dress conduct blinded reproducibility study mrs patients undergone surgical treatment lung cancer china study uses kappa statistic measure concordance discrete variables uses correlation coefficient measure reproducibility continuous variables results using dress demonstrated feasibility extracting clinical data unstructured mrs create semi structured patient centered electronic health record database reproducibility study patient mrs shown overall high reproducibility varies across six modules pathology radio chemo therapy clinical examination surgery information medical image general patient information conclusions dress uses double reading double entry independent adjudication manually curate structured data elements unstructured clinical data distributed computing strategies dress protects data privacy dividing data identified modules finally internet based computing cloud dress enables many data specialists work virtual environment achieve necessary scale processing thousands mrs within days hybrid system represents probably workable solution solve big medical data challenge
background hemoglobin alc hbac measurement great value diagnosis monitoring diabetes many manufacturers developed various experiments determine hbalc concentration however longitudinal use tests requires strict quality management study aimed analyze quality hbalc measurement systems china using six sigma techniques help improve performances methods total laboratories involved investigation bias values coefficients variation collected hba trueness verification external quality assessment program internal quality control program organized national center clinical laboratories china sigma sigma values quality goal index qgi used evaluate performances different groups divided according principles instruments results majority participants scored improvement needed sigma among laboratories whose values laboratories needed improve measurement precision qgi respectively remaining laboratories needed improve measurement precision trueness addition laboratories tosoh arkray groups respectively scored world class whereas none laboratories bio rad group scored world class conclusions study indicated although participating laboratories laboratories better performance china performances still unsatisfactory actions taken improve hbalc measurement performance include hbalc assays diabetes diagnosis china
background hereditary proximal spinal muscular atrophy sma severe neuromuscular disease childhood caused homozygous loss function survival motor neuron smn gene presence second nearly identical smn gene smn human genome ensures production residual levels ubiquitously expressed smn protein alpha motor neurons ventral horns spinal cord vulnerable reduced smn concentrations development function tissues may also affected cardiovascular abnormalities frequently reported patients sma mouse models methods systematically reviewed reported cardiac pathology relation smn deficiency investigate relevance possible association detail used clinical classification systems characterize structural cardiac defects arrhythmias conclusions seventy two studies total sma patients reported cardiac pathology identified along publications sma mouse models abnormalities heart structural cardiac pathology mainly septal defects abnormalities cardiac outflow tract reported predominantly severely affected patients sma type cardiac rhythm disorders frequently reported patients milder sma types sma type included studies lacked control groups standardized approach cardiac evaluation convergence specific abnormalities cardiac structure function may indicate vulnerability specific cell types developmental processes relevant cardiogenesis future studies would benefit controlled standardized approach cardiac evaluation patients sma
background high prevalence rates psychological distress medical training later professional life indicate need prevention different types intervention shown good effects little known relative efficacy different types stress management interventions methodological limitations reported order overcome limitations present study aimed evaluating effect specifically developed mindfulness based stress prevention training medical students medimind measures distress coping psychological morbidity methods report prospective randomized controlled trial three study conditions experimental treatment medimind standard treatment autogenic training control group without treatment sample consisted medical dental students second eighth semester completed self report questionnaires baseline training one year follow distress trier inventory assessment chronic stress tics assessed primary outcome coping brief cope primary outcome effects psychological morbidity brief symptom inventory bsi secondary outcome expected one year trainings results initially students randomly allocated study groups one year follow could included per protocol analysis medimind autogenic training control group selective drop students suffered often psychological symptoms detected mancova tics brief cope revealed significant interaction effects bsi significant overall interaction effect became apparent eta partial post hoc analyses significant means global severity index bsi indicated medimind may contribute decrease psychological morbidity conclusion due high selective dropout rates results generalized research necessary since participation rate trainings high need prevention programs indicated study gives important suggestions implementation evaluation stress prevention medical schools
background hiv infection associated early menopausal onset may adverse long term health consequences antimullerian hormone biomarker ovarian reserve gonadal aging reduced hiv infected women objective sought assess relationship antimullerian hormone age menopause onset hiv infected women study design used antimullerian hormone levels measured plasma hiv infected participants women interagency hiv study model age final menstrual period multivariable normal mixture models censored data used identify factors associated age final menstrual period results higher antimullerian hormone age years associated later age final menstrual period even multivariable adjustment smoking cell count plasma hiv rna hepatitis infection history clinical aids doubling antimullerian hormone associated year increase age final menstrual period median age final menstrual period ranged years percentile antimullerian hormone years percentile factors independently associated earlier age final menstrual period included smoking hepatitis infection higher hiv rna levels history clinical aids conclusion antimullerian hormone highly predictive age final menstrual period hiv infected women measuring antimullerian hormone hiv infected women may enable clinicians predict risk early menopause potentially implement individualized treatment plans prevent menopause related comorbidities aid interpretation symptoms
background hiv infection linked decreased fertility fertility desires sub saharan africa due biological social factors investigate relationship hiv infection fertility fertility desires context universal access antiretroviral therapy introduced rwanda methods used data women aged rwandan demographic health surveys rdhs respectively rdhss included blood tests hiv well detailed interviews fertility demographic behavioral outcomes years multiple logistic regression used assess association hiv fertility outcomes within three age categories years controlling confounders compensating complex survey design results find difference odds pregnancy last years hiv seropositive hiv seronegative women controlling potential biological social confounders controlling confounders found hiv seropositive women age less likely desire children compared hiv seronegative women years adjusted odds ratio aor years aor difference found among women aged older associations hiv fertility fertility desire found conclusions findings suggest difference births current pregnancy among hiv seropositive hiv seronegative women hiv seropositive women earlier childbearing years desired fewer children hiv seronegative women could suggest women hiv survived stigma fear transmitting hiv realism living hiv prematurely dying hiv may affect desire children findings emphasize importance delivering appropriate information pregnancy childbearing hiv infected women enabling women living hiv make informed decisions reproductive life
background hiv increasingly considered chronic illness individuals living longer aging health related consequences associated hiv multi morbidity exercise self management approach promote health people aging hiv examined safety effectiveness progressive resistive exercise pre interventions immunological virological cardiorespiratory strength weight body composition psychological outcomes adults living hiv methods conducted systematic review using cochrane collaboration protocol searching databases april included randomized controlled trials compared pre exercise another intervention performed least three times per week least four weeks adults living hiv two reviewers independently determined study eligibility extracted data included studies assessed risk bias using cochrane collaboration risk bias tool meta analyses conducted using random effects models review manager revman computer software results twenty studies met inclusion criteria participants study completion majority participants men taking antiretroviral therapy included studies exercise interventions included pre alone studies combination resistive aerobic exercise studies ranging weeks duration thirty four meta analyses performed results demonstrated statistically significant improvements cardiorespiratory status maximum oxygen consumption exercise time strength chest press knee flexion weight body composition arm thigh girth leg muscle area among exercisers versus non exercisers found significant differences change count viral load unable perform meta analyses psychological outcomes however results individual studies demonstrated improvements health related quality life exercisers compared non exercisers conclusions performing progressive resistive exercise pre combination resistive aerobic exercise least three times per week least six weeks safe lead improvements cardiorespiratory fitness strength weight body composition adults hiv exercise may considered safe beneficial enhancing health medically stable adults aging hiv
background hodgkin lymphoma one prevalent lymphoproliferative disorders pakistan however risk factors disease yet established population epstein barr virus ebv well known risk factor hodgkin lymphoma endemic regions world however frequency association population widely studied latent membrane protein lmp expression immunohistochemistry ihc surrogate marker ebv hodgkin lymphoma therefore aimed evaluate frequency expression lmp cases hodgkin lymphoma institute correlation clinical histologic parameters methods study included cases hodgkin lymphoma diagnosed liaquat national hospital duration years january december slides blocks cases retrieved representative blocks selected lmp ihc lmp expression cells considered positive expression correlated histologic subtypes clinical parameters like age gender site involvement results mean age patients lmp expression found cases hodgkin lymphoma mean age patients lmp expression lmp expression found cases lymphocyte rich lymphocyte depleted mixed cellularity nodular sclerosis classic hodgkin lymphoma nos significant correlation lmp expression clinical histological parameter could established studied patient population conclusions high frequency expression lmp seen cases hodgkin lymphoma setup comparable endemic regions world therefore preventive treatment protocols designed accordingly
background home parenteral nutrition hpn mainstay treatment patients type intestinal failure however long term data mortality nutritional outcomes limited objectives assess long term survival requirements ongoing hpn patients receiving treatment national referral centre intestinal failure methods patients received hpn months intestinal failure unit clinical records reviewed spss utilised perform cox regression analysis generate kaplan meier curves aim identifying factors associated death continued need hpn results case notes patients reviewed overall survival patients without malignancy commencement years starting treatment crohn disease mesenteric ischaemia chronic intestinal pseudo obstruction associated better scleroderma radiation enteritis multivariate analysis older age onset associated poor shorter small bowel length central line sepsis deaths due complications hpn central line sepsis associated liver disease continued hpn dependence survivors years respectively among patients without malignancy achieved nutritional independence hpn surgical reconstruction alimentary tract hpn duration mean months range months patients weaned hpn without undergoing surgical reconstruction conclusion largest reported data set long term survival dependence hpn inform indications benefits risks treatment disease specific groups significant proportion patients achieved nutritional autonomy without surgical intervention elsevier ltd european society clinical nutrition metabolism rights reserved
background hospitalization events exact substantial toll across age spectrum frailty associated cause hospitalization among hiv uninfected adults aged years older limited data exist frailty relationship hospitalization among hiv infected persons aged less years comparative investigation frailty relationship specific classes hospitalizations rarely reported among adults age study sought determine frailty relationship three distinct classes hospitalization events among hiv infected persons uninfected counterparts methods frailty ascertained semiannually among persons prior injection drug use using five fried phenotypic domains hospitalization events categorized using agency healthcare research quality clinical classification software chronic infectious nonchronic noninfectious conditions cox proportional hazards models used examine frailty relationship time first hospitalization event results among subjects mean age years hiv infected adjusting sociodemographics comorbidity substance use hiv disease stage time updated frailty status associated risk hospitalization classes baseline frailty significantly associated cause hazards ratio confidence interval chronic infectious disease hospitalization nonchronic noninfectious hospitalization risk conclusion frailty phenotype predicts vulnerability chronic infectious disease related hospitalization frailty targeted interventions may mitigate substantial burden infectious chronic disease related morbidity health care utilization hiv infected uninfected populations
background hypertension high blood pressure rise affect elderly also increasingly spreading younger sectors population treating condition involves exhaustive monitoring patients current mobile health services improved perform task effectively objective develop useful user friendly robust efficient app monitor hypertensive patients adapted particular requirements hypertension methods work presents bpcontrol android ios app allows hypertensive patients communicate health care centers thus facilitating monitoring diagnosis usability robustness efficiency factors bpcontrol evaluated different devices operating systems android ios system aware furthermore features compared similar apps literature results bpcontrol robust user friendly respective start efficiency android ios versions bpcontrol times faster system aware app similar values obtained communication efficiency times faster android ios respectively comparing plotting performance bpcontrol average times faster android case apps literature communication server thus making impossible compare performance bpcontrol conclusions optimal design good behavior facilities make bpcontrol promising mobile app monitoring hypertensive patients
background hypofractionation become standard care breast conserving therapy bct many european others western countries though still debatable tumor cavity boost routinely practised centre hypofractionation yet current standard practice asian countries employing hypofractionation simultaneous integrated boost lumpectomy cavity conformal technique current practice region hence study performed see whether accelerated hypofractionation simultaneous boost combined using volumetric modulated arc therapy vmat treating early breast cancer ebc patients patients methods female patients ebc treated whole breast radiation boost treated simultaneously dose fifteen fractions three weeks entire breast tumor cavity respectively vmat dosimetry including target coverage oar organ risk sparing acute radiation toxicity evaluated results ten consecutive patients treated planning target volume ptv coverage oar sparing mostly satisfactory mean volume ptvwb ptvboost respectively mean dmean ptvwb ptvboost respectively max ptvwb ptvboost respectively ipsilateral lung mean dose respectively heart respectively patients disease free median follow two years acute toxicities grade two patients ten developed grade skin reaction radiation early cosmesis using harvard cosmesis scale good excellent conclusions accelerated hypofractionated using sib vmat clinically feasible technique acceptable initial result initial results encouraging mini abstract simultaneous integrated boost accelerated hypofractionated whole breast radiotherapy using volumetric modulated arc therapy novel approach patient selection technical considerations paramount importance present study describes successful implementation approach national cancer institute cairo university production hosting elsevier open access article license
background hypogonadism men total testosterone associated higher risk cardiovascular disease mortality men dialysis therapy evaluated association hypogonadism cause mortality men non dialysis dependent chronic kidney disease ckd study design retrospective cohort study setting participants men ckd stages estimated glomerular filtration rate min total testosterone measured cause january october tertiary care center cleveland predictors total testosterone measured using immunoassay measurement forms categorized low testosterone replacement therapy versus normal continuous log testosterone quintiles outcomes factors associated low total testosterone level association low total testosterone level cause mortality evaluated using logistic regression cox proportional hazard models kaplan meier survival curves results hypogonadism found men multivariable logistic regression analysis african american ethnicity higher estimated glomerular filtration rate associated lower odds hypogonadism diabetes higher body mass index associated higher odds hypogonadism patients died median follow years multivariate cox model testosterone level testosterone replacement therapy associated mortality multivariable model also adjusted testosterone supplementation higher log testosterone associated significantly lower mortality per log unit compared highest quintile second lowest quintile testosterone associated higher mortality limitations single center study timing testosterone testing lack adjustment proteinuria sampling bias conclusions low total testosterone level may associated higher mortality men ckd stages studies needed national kidney foundation inc
background ibrutinib idelalisib venetoclax approved treating cll patients united states however guidance optimal sequence patients methods conducted multicenter retrospective analysis cll patients treated kinase inhibitors kis venetoclax examined demographics discontinuation reasons overall response rates orr survival post salvage strategies primary endpoint progression free survival pfs results total patients identified baseline characteristics similar ibrutinib idelalisib groups orr ibrutinib idelalisib first respectively median follow months range median pfs entire cohort months reached patients treated ibrutinib versus idelalisib first significantly better pfs settings front line hazard ratios relapsed refractory delp complex karyotype time initial failure use alternate venetoclax superior pfs compared chemoimmunotherapy furthermore patients discontinued ibrutinib due progression toxicity marginally improved outcomes received venetoclax orr versus idelalisib orr pfs conclusions largest real world experience novel agents cll ibrutinib appears superior idelalisib first furthermore setting failure alternate venetoclax therapy appear superior chemoimmunotherapy combinations use venetoclax upon ibrutinib failure might superior idelalisib data support need trials testing sequencing strategies optimize treatment algorithms
background identifying neural profiles predictive future psychopathology risk individuals important efficiently direct preventive care alterations reward processing may risk factor depression current study characterized neural substrates reward processing children low high risk psychopathology due maternal depression status methods children without maternal depression ages years performed monetary incentive delay task received rewards successfully hit target reward regardless performance fmri acquisition results multiple dorsal prefrontal temporal striatal regions showed significant group high lowrisk xperformance hit miss xcondition reward reward interactions whole brain analysis regions exhibited similar patterns whereby high risk group showed blunted activation differences trials without rewards participants hit target moreover high risk children showed activation differences trials without rewards opposite direction compared low risk group missed target limitations study modest sample size though larger existing studies children maternal depression elevated risk future psychopathology yet experience clinically significant symptoms longitudinal research necessary fully track pathway risk disorder conclusion children depressed mothers exhibited attenuated neural activation differences activation patterns opposite children without depressed mothers findings may provide targets hypothesis driven preventive interventions lead earlier identification individuals risk
background idiopathic toxic pulmonary fibrosis severe diseases starting classically subpleural area lung recently suggested pleural mesothelial cells acquire myofibroblast phenotype fibrotic conditions induced tgf beta bleomycin importance role inflammation fibrogenesis still controversial work explored role beta caspase signaling bleomycin lung toxicity pleural mesothelial cell transformation methods cbl mice intravenously injected either bleomycin nigericin nacl control vitro meta cell line used model human pleural mesothelial cells results intravenous injections bleomycin induced lung fibrosis histologically proven peripheral distribution collagen accumulation pleural subpleural area overexpression markers myofibroblast transformation pleural cells migrated lung events associated inflammatory process increase neutrophil recruitment pleural lavage fluid increased caspase activity tgf beta also overexpressed pleural lavage fluid produced pleural cells following intravenous bleomycin model local pleural inhibition beta beta inhibitor anakinra diminished tgf beta collagen accumulation vitro caspase inhibition interfered meta cell transformation myofibroblast like phenotype induced bleomycin tgf beta moreover nigericin caspase activator triggered transformation meta cells intra pleural delivery induced fibrogenesis mice conclusions demonstrated intravenous bleomycin injection mice role pleura highlighted key role beta caspase axis fibrogenesis process
background idiopathic nonspecific interstitial pneumonia insip presents varying degrees interstitial inflammation fibrosis exhibiting uniform appearance lack knowledge underlying mechanisms insip contributed effective treatment strategies study designed explore aberrantly expressed cytokines involvement insip development methods oligo gearray employed detect expression cytokines insip patients idiopathic pulmonary fibrosis ipf setup isotype control real time pcr immunohistochemistry analysis used confirm expression abnormally expressed cytokines correlationship cytokines expression overall survival rate patients ipf insip analyzed results microarray detection transforming growth factor beta tgf beta fibroblast growth factor fgf platelet derived growth factor pdgf predominantly regulated patients insip real time pcr immunohistochemistry also showed cytokines abnormally expressed insip addition clinical relevance analysis demonstrated relatively lower expression pdgf patients longer overall survival rate higher expression pdgf conclusions study suggests tgf beta fgf pdgf required pathogenesis insip may therefore ideal targets insip treatment moreover insip patients lower expression pdgf better survival rate
background idiopathic pulmonary fibrosis ipf chronic progressive interstitial lung disease severe pulmonary fibrosis main cause ipf associated death acute exacerbation ipf ipf study aims develop rat model ipf two intratracheal perfusions bleomycin blm methods ninety male sprague dawley rats randomized three groups ipf model group blm blm group ipf model group blm group normal control group rats blm blm group underwent second perfusion blm day first perfusion blm rats two groups received saline second perfusion six rats group sacrificed day day day first perfusion respectively additional rats group observed survival results rats blm blm group significantly worse pulmonary alveolar inflammation fibrosis rats blm group rats blm blm group also developed large amounts hyaline membrane showed high levels albumin alb various inflammatory factors bronchoalveolar lavage fluid balf markedly increased lung water content furthermore rat survival reduced blm blm group pathophysiological characteristics rats blm blm group resemble patients ipf conclusions second perfusion blm appears induce acute exacerbation pulmonary fibrosis may used model ipf rats
background idiopathic pulmonary fibrosis ipf lethal lung disease unknown etiology major limitation transcriptomic profiling lung tissue ipf dependence snap frozen fresh tissues project sought determine whether genome scale transcript profiling using rna sequencing rna seq could applied archived formalin fixed paraffin embedded ffpe ipf tissues results isolated total rna ipf control ffpe lung tissues performed base pair paired end sequencing illumina hiseq tophat used map sequencing reads human genome average similar million reads similar million reads mapped per sample genes differentially expressed ipf controls increased decreased fdr compared results differentially expressed genes calculated previously published dataset generated tissues analyzed agilent microarrays gse overlap differentially expressed genes high increased decreased fdr differentially expressed genes changed opposite directions pathway enrichment analysis performed using metacore confirmed numerous ipf relevant genes pathways including extracellular remodeling tgf beta wnt gene network analysis mmp highly differentially expressed gene datasets revealed canonical pathways gene network candidates rna seq microarray data validation nanostring ncounter selected genes fold change least one dataset discordant significantly differentially expressed one dataset concordant genes high concordance fold change fdr observed type samples ffpe microarrays rna seq number discordant genes reduced four conclusions results demonstrate rna sequencing rna obtained archived ffpe lung tissues feasible results obtained ffpe tissue highly comparable tissues ability perform rna seq archived ffpe ipf tissues greatly enhance availability tissue biopsies research ipf
background idiopathic pulmonary fibrosis ipf characterized complex interaction cells involved chronic inflammation fibrosis global gene expression homogenous cell population identify novel candidate genes methods gene expression fibroblasts derived lung tissues ipf controls profiled ontology functional pathway analyzed genes exhibiting absolute fold changes values fold change among novel relation ipf ccl expression fold higher ipf fibroblasts levels ccl mrna protein fold higher ipf fibroblasts control fibroblasts real time pcr elisa respectively ccl concentrations bal fluid significantly higher patients ipf controls interstitial lung diseases including non specific interstitial pneumonia hypersensitivity pneumonitis sarcoidosis showed shorter survival compared lower levels ccl expressed sma positive cells interstitium ipf conclusions transcriptome analysis identified several novel ipf related genes among ccl candidate molecule differential diagnosis prediction survival
background immune mediated diseases rheumatoid arthritis ankylosing spondylitis inflammatory bowel disease ibd commonly affect young adolescent females anti tumor necrosis factor tne alpha agents increasingly used treat conditions safety pregnancy remains unclear objectives evaluate risk pregnancy related outcomes patients various immune mediated diseases treated anti tnf alpha agents methods electronic databases searched studies assessing outcome pregnancy female patients various immune mediated diseases treated anti tnf alpha agents direct network meta analyses performed anti tnf alpha users non users general population results thirteen studies including ibd various immune mediated diseases identified among studies compared outcome anti tnf alpha users general population anti tnf alpha users non significant trend towards reduced rate live birth odds ratio confidence interval significantly increased risk preterm birth spontaneous abortion low birth weight compared general population risk anomalies elevated among studies compared outcome anti tnf alpha users non users significant differences rates live birth pregnancy related complications among studies compared outcome non anti tnf alpha users general population risk spontaneous abortion elevated significant differences rates live birth pregnancy related complications network meta analysis confirmed rank order outcomes general population non users users anti tnf alpha agents ascending order based safety conclusions female patients immune mediated diseases treated anti tnf alpha agents significantly increased risks preterm birth spontaneous abortion low birth weight compared general population comparable outcomes non users results provide useful information female patients reproductive age raise awareness conditions facing among clinicians managing care elsevier ltd rights reserved
background immunosuppressive therapy places pediatric patients risk developing life threatening sinonasal infections diagnosis treatment challenging owing nonspecific signs symptoms aim study present department experience surgical management acute rhinosinusitis immunosuppressed children methods records children hematologic oncologic disease underwent endoscopic sinus surgery ess acute rhinosinusitis january may reviewed data retrospectively collected demographics clinical imaging characteristics microbiology pathology treatment outcome results thirty four immunosuppressed children underwent ess acute rhinosinusitis patients fungal infection nineteen patients died end follow deaths infection related facial swelling symptom correlated death infection relapse underlying disease bone marrow transplantation long duration neutropenia correlated infection related mortality fungal infection specifically aspergillus correlated death infection conclusions ess safe efficient procedure diagnosing treating immunosuppressed pediatric patients acute rhinosinusitis early detection aggressive medical surgical treatment control underlying risk factors crucial improve outcome
background impaired heart functions newborns hypothyroidism reversed levothyroxine substitution therapy aim study investigate heart functions congenital hypothroidism newborns changes levothyroxine substitution therapy measured tissue doppler echocardiography conventional echocardiography methods study included neonates healthy controls echocardiography performed baseline week month therapy results heart systolic function normal mitral velocities mitral ratios significantly lower patients baseline tei indices significantly higher patients significant negative correlation detected free thyroxine levels tei indices early late post treatment echocardiography findings compared non significant difference detected conclusions neonates may exhibit systolic diastolic heart dysfunction reversed early substitution treatment tei index index measured addition conventional echocardiography
background impaired interpretation nonverbal emotional cues patients schizophrenia reported several studies clinical relevance deficits social functioning assumed however unclear extent impairments depend specific emotions specific channels nonverbal communication methods effect cue modality emotional categories accuracy emotion recognition evaluated patients schizophrenia compared healthy control group end dynamic stimuli comprising speakers genders three different sensory modalities auditory visual audiovisual five emotional categories happy alluring neutral angry disgusted used results patients schizophrenia found impaired emotion recognition comparison control group across stimuli considering specific emotions severe deficits revealed recognition alluring stimuli less severe deficits recognition disgusted stimuli compared emotions regarding cue modality extent impairment emotional recognition significantly differ auditory visual cues across emotional categories however patients schizophrenia showed significantly severe disturbances vocal compared facial cues sexual interest expressed alluring stimuli whereas severe disturbances facial compared vocal cues observed happiness anger expressed conclusion results confirmed perceptual impairments observed vocal well facial cues conveying various social emotional connotations observed differences severity impairments severe deficits alluring expressions might related specific difficulties recognizing complex social emotional information interpersonal intentions compared basic emotional states therefore future studies evaluating perception nonverbal cues consider broader range social emotional signals beyond basic emotions including attitudes interpersonal intentions identifying specific domains social perception particularly prone misunderstandings patients schizophrenia might allow refinement interventions aiming improving social functioning
background impeccable assessment symptoms central palliative care practice objectives study objectives test validity arabic questionnaire symptom assessment aqsa self administered tool assessing severity listed symptoms among patients test validity aqsa completed proxy methods aqsa tool assessing severity symptoms addition overall suffering experience numeric scale symptom scores aqsa compared scores obtained interviews patients procedure repeated patients sitters explore validity using tool symptom assessment proxy results study involved pairs patient sitter mean age years females patients years females sitters correlation coefficient agreement interview based scores patients ranged drowsiness pain aqsa showed positive correlation sitters patients scores ranging depression vomiting conclusions strong positive correlation aqsa indicates former valid tool aqsa used proxy showed moderate strong positive correlation patients actual scores symptoms
background improvement quality life crucial hiv infected people social behavioral interventions implemented different contexts improve quality life among hiv infected people review appraises evidence available interventions focused quality life hiv infected people receiving antiretroviral therapy art methods searched electronic databases randomized controlled trials interventions improve quality life hiv infected people receiving art searched pubmed cochrane centre register controlled trials central terms social behavioral educational quality life hiv rct searches conducted articles published december standardized data abstraction methods searching steps applied results twenty eight studies reported impact social behavioral interventions quality life among hiv infected people conducted united states america total participants enrolled studies four studies included females two studies included males remaining studies excluded males females overall reported methodological quality studies subject high risk bias study criteria unclear studies twenty one studies reported significant intervention effect least one quality life domain meta analyses showed significant improvement general health mental health physical function environment domains quality life among intervention groups however expected impact intervention low moderate rigorousness studies low information limited sample sizes small quality study designs poor conclusions although available evidence suggests existing social behavioral interventions improve quality life domains quality evidence insufficient support notion interventions improve overall quality life hiv infected people receiving art well designed rigorous randomized controlled trials high methodological quality required
background impulsivity multidimensional low impulse control may result behavioural disorders acting spur moment may also advantageous previous studies shown negative associations different facets impulsivity serotonergic function investigations found negative correlations serum lipid levels impulsivity methods investigated whether functional polymorphism serotonin hta receptor gene htra associated impulsivity levels whether interaction serum lipid levels analysis based data population representative estonian children personality behaviour health study age impulsivity self reported adaptive maladaptive impulsivity scale results subjects genotype htra polymorphism higher scores maladaptive impulsivity adaptive impulsivity females high ldl total cholesterol levels increased genotype effect males highest quartile total ldl cholesterol genotype effect altered homozygotes highest maladaptive impulsivity levels limitations one cohort european youth heart study eyhs used current study impulsivity measures self reported conclusions results support notion low cholesterol levels universally lead higher impulsivity found high total ldl cholesterol levels moderate effect htra gene promoter polymorphism suggests future studies impulsivity need consider interaction serotonergic measures whole range cholesterol levels elsevier rights reserved
background field video game violence experienced serious reversals repudiations current research supreme court australian government non compelling fundamentally flawed scholars calling higher quality research issue current study seeks answer call providing longitudinal data youth aggression dating violence potential consequences violent video game exposure using well validated clinical outcome measures controlling relevant predictors youth aggression method sample mainly hispanic youth tested intervals initial interview year year intervals results results indicated exposure video game violence related negative outcomes depression antisocial personality traits exposure family violence peer influences best predictors aggression related outcomes interpretation current study supports growing body evidence pointing away video game violence use predictor youth aggression public policy efforts including funding would best served redirecting toward prevention programs youth violence elsevier ltd rights reserved
background japan bivalent hpv vaccine approved october became available non routine vaccine december routine vaccinations free cost responsibility non routine vaccinations left individual exceptional circumstances regional governments fund non routine vaccinations case shiki city saitama prefecture high uptake rate individual non school based hpv vaccination obtained materials january mayor shiki city announced media decision vaccinate adolescent girls shiki city hpv project team hpv vaccination set city health promotion center gain mutual consent hpv vaccination senior health professionals city officials head board education school principals health care teachers met several times cohort vaccinated girls aged years individual notifications mailed girl april along information hpv vaccine conclusions april uptake rate girls aged years old dose vaccine registry managed health care system city success hpv vaccination program high uptake rates shiki city good model nationwide hpv vaccination program started february elsevier ltd rights reserved
background many countries opioid agonists buprenorphine methadone licensed maintenance treatment opioid dependence many short term studies performed little known long term effects therefore study described years mortality retention abstinence rates changes concomitant drug use somatic mental health methods prevalence sample maintenance patients recruited nationally representative sample substitution doctors evaluated year prospective longitudinal naturalistic study months patients assessed outcome full outcome data primary outcome data died individuals lost follow results year retention rate average mortality rate follow patients became abstinent referred drug free addiction treatment concomitant drug use decreased somatic health status social parameters improved conclusions study provides evidence efficacy safety maintenance treatment opioid agonists long term number opioid free patients low patients less continuously opioid maintenance therapy implications discussed karger basel
background patients mild moderate parry romberg syndrome prs plastic surgeons mainly focused restoration soft tissue deficiencies bone deficits easily overlooked study developed new method combines autologous mandibular outer cortex moc grafting fat grafting mild moderate patients prs apply computer assisted techniques improve surgical outcomes accuracy methods seven patients mild moderate prs prospectively enrolled study preoperative days months postoperative computed tomography photographs performed computer aided design done based preoperative data surgical templates moc harvesting grafting designed printed topographic map fat grafting generated accuracy moc bone grafting evaluated moc thickness relative error moc thickness accuracy preop severe bone atrophy point preop msbap moc volume accuracy percentage volume maintenance fat grafting surgery assessed results patients ideal clinical outcomes significant improvement facial symmetry major complications happened average moc thickness relative error average moc thickness accuracy preop msbap average moc volume accuracy average percentage volume maintenance fat grafting conclusions combination moc grafting fat grafting excellent choice reconstruction mild moderate patients prs applying computer assisted techniques offers reliable accurate outcome
background pigs perinatal period critical time survival piglet maturation occurs end gestation leads state full development birth therefore maturity important determinant early survival skeletal muscle plays key role adaptation extra uterine life glycogen storage thermoregulation study performed microarray analysis identify genes biological processes involved piglet muscle maturity progeny two breeds extreme muscle maturity phenotypes analyzed two time points gestation gestational days large white breed selected breed increased rate mortality birth whereas meishan breed produces piglets extremely low mortality birth impact parental genome analyzed reciprocal crossed fetuses results microarray analysis identified differentially expressed probes gestational age genotype high number reflects important transcriptomic change occurs days gestation probes corresponding unique annotated genes involved particularly maturation process studied functional enrichment graph inference studies underlined genes involved muscular development around days gestation genes involved metabolic functions gluconeogenesis around days gestation moreover difference expression key genes pck ldha pgk detected birth reciprocal crossing analysis resulted identification genes expression preferentially regulated one parental genome genes regulated paternal genome among paternally regulated genes known imprinted genes magel igf identified could key role maturation process conclusion results reveal biological mechanisms regulate muscle maturity piglets maturity also conflicting regulation parental genomes crucial genes could explain biological differences maturity observed breeds identified genes could excellent candidates key role maturity
background spain law came effect january turning point smoking regulation prevention serving guarantee progress future strategies direction marked international organizations expected regulatory policy benefit relatively lower socioeconomic groups thus contributing reduction socioeconomic health inequalities research analyzes effect tobacco regulation spain law initiation cessation tobacco consumption whether effect unequal across distinct socioeconomic levels methods micro data national health survey editions used study numbers respectively inventory statistical operations iso code sample size approximately households divided census areas allows individuals tobacco consumption records reconstructed five years initiation survey well identifying individuals started stopped smoking methodology based time event analysis cox proportional hazard models adapted show effects set explanatory variables conditional probability change tobacco consumption initiation daily smoker young people cessation daily smoking adults results initiation rates among young people went confidence interval following implementation law change cessation rates among smokers even greater rates increasing however effect equal socioeconomic groups shown relative risks regulation policy social class statistically significant factor initiation daily smoking however following implementation law young people belonging social classes relative risk starting smoking higher young people higher social classes hand lower social class also means lower probability smoking cessation however relative risk cessation smoker belonging household social class compared classes went lower law lower following law implementation conclusion law effective promulgation decrease rate smoking initiation among young people increase rate cessation among adult smokers however effect equal socioeconomic groups favoring relatively individuals belonging higher social classes
background emergency setting non traumatic headache benign symptom cases serious underlying conditions need ruled copeptin improves risk stratification several acute diseases herein investigated value copeptin discriminate serious secondary headache benign headache forms emergency setting methods patients presenting acute non traumatic headache prospectively enrolled observational cohort study copeptin measured upon presentation emergency department primary endpoint serious secondary headache defined neurologic cause requiring immediate treatment underlying disease secondary endpoint combination mortality hospitalization within months two board certified neurologist blinded copeptin levels verified endpoints structured month telephone interview results patients included serious secondary headache copeptin associated serious secondary headache focal neurological abnormalities thunderclap onset symptoms copeptin remained independent predictive factor serious secondary headache moreover copeptin improved auc multivariate logistic clinical model test even though copeptin values higher patients reaching secondary endpoint association significant multivariate logistic regression conclusions copeptin independently associated serious secondary headache compared benign headaches forms copeptin may promising novel blood biomarker validated rule serious secondary headache emergency department
background fitquit randomised controlled trial insufficiently active adult cigarette smokers contacted quitline support quit smoking randomised usual quitline support also receive contacts icer point prevalence sic ppp adjusted adherent subgroup markov model estimated discounted quality adjusted life year gains lifetime year old males icer sic ppp adjusted females icer sic ppp adjusted conclusions exercise counselling intervention cost effective adherence minimum intervention calls turn leads sufficient number quitters health gains
background individuals high risk develop alcoholism often manifest neurocognitive deficits well increased impulsivity goal present study elucidate reward processing deficits externalizing disorders impulsivity elicited electrophysiological clinical behavioral measures subjects high risk alcoholism families densely affected alcoholism context brain maturation across age groups gender methods event related potentials erps current source density csd monetary gambling task mgt measured year old offspring families collaborative study genetics alcoholism coga prospective study high risk subjects families densely affected alcoholism low risk subjects community families externalizing disorders impulsivity scores also compared groups results offspring older years male younger years female subgroups showed lower amplitude subjects amplitude decrement prominent males loss condition overall amplitude increase anterior sites decrease posterior areas seen older compared younger subjects suggesting frontalization brain maturation subgroups also exhibited hypofrontality manifested weaker csd activity loss gain conditions frontal regions fir subjects higher impulsivity scores increased prevalence externalizing disorders amplitudes gain condition negatively correlated impulsivity scores conclusions older male younger female offspring compared counterparts manifested reward processing deficits indexed lower amplitude weaker csd activity along higher prevalence externalizing disorders higher impulsivity scores significance reward related valuable measure reflecting neurocognitive dysfunction subjects risk alcoholism well characterize reward processing brain maturation across gender age group elsevier rights reserved
background individuals traumatic brain injury tbi often difficulty processing nonverbal communication ekman published research area focused tbi patient ability recognize facial expression vocal intonation postural expression croker hopkins dywan segalowitz objective study compared non verbal processing skills brain injured patients versus non injured controls three domains methods stimuli photographs facial postural expressions audio recordings intonational expressions results results indicated persons tbi particular difficulty recognizing non verbal communication resulting vocal intonations conclusions tbi patients difficulty processing tonality therefore reasonable suggest clinicians friends family members emphasize explicit verbal content spoken language speaking person tbi
background individuals intermittent explosive disorder ied previously found exhibit amygdala hyperactivation relatively reduced orbital medial prefrontal cortex ompfc activation angry faces performing implicit emotion information processing task functional magnetic resonance imaging fmri study examines neural substrates associated explicit encoding facial emotions among individuals ied method twenty unmedicated ied subjects twenty healthy matched comparison subjects underwent fmri viewing blocks angry happy neutral faces identifying emotional valence face positive negative neutral compared amygdala ompfc reactivity faces ied subjects also examined relationship amygdala ompfc activation aggression severity results compared controls ied group exhibited greater amygdala response angry neutral facial expressions contrast ied control groups differ ompfc activation angry faces across subjects amygdala activation angry faces correlated number prior aggressive acts conclusions findings extend previous evidence amygdala dysfunction response identification ecologically valid social threat signal processing angry faces among individuals ied substantiating link amygdala hyperactivity social signals direct threat aggression elsevier ltd rights reserved
background infective exacerbations copd common accompanied neutrophilic bronchitis sputum increased respiratory iron content associated respiratory tract infection though unclear represents predisposing factor infection sequelae inflammation iron overload assessed airways may important biomarker recurrent infective exacerbations copd purpose study determine hemosiderin sputum macrophages related infective exacerbations copd methods undertook retrospective observational study consecutive patients presented exacerbation copd sputum examined including assessment hemosiderin alveolar macrophages relation infective exacerbations previous two years percent hemosiderin positive macrophages analyzed linear regression account non parametric distribution infective exacerbations negative binomial regression modelling used account covariates results percent hemosiderin positive alveolar macrophages hemosiderin index analyzed parametrically non parametrically demonstrated significant correlation increasing numbers infective exacerbations previous two years multivariate regression analysis hemosiderin index independent predictor infective exacerbations copd patients raised hemosiderin index higher levels sputum compared patients lower levels conclusions high hemosiderin index sputum alveolar macrophages measured time aecopd may related frequency infective exacerbations copd
background inflammatory bowel diseases ibd including crohn disease ulcerative colitis characterized chronic inflammation intestine reduce absorption nutrients vitamin calcium objective investigate bone alterations serum levels vitamin patients ibd method cross sectional study based review medical records patients private office curitiba brazil serum levels vitamin bone densitometry measured diagnosis ibd total patients included irritable bowel syndrome ibs comparison group results compared patients patients showed higher prevalence bone alterations osteoporosis osteopenia bone alterations occurred cases osteoporosis osteopenia vitamin levels among patients vitamin deficiency insufficiency sufficient cases deficiency insufficiency sufficient serum levels vitamin group ibs deficiency observed cases insufficiency sufficiency significant difference groups conclusion ibd patients high prevalence bone changes especially serum levels vitamin recommended evaluated groups
background initiating tobacco use adolescence increases risk nicotine dependence continued smoking physician screening tobacco use increases odds physicians intervening patients smoke however without appropriate follow physician screening tobacco use enough significantly increase cessation rates given critical phase development adolescence poses tobacco use evidence physician intervention improves adult cessation efforts sought examine physician tobacco use screening advice quit among adolescents years methods using data national survey drug use health nsduh examined prevalence correlates tobacco use screening adolescent respondents reported visiting physician within past year multivariable logistic regression analyses explored relationship tobacco use screening physician advice quit sub set sample reported physician advice quit controlling sociodemographics cigarette use substance use screening results adolescents visited physician within past year reported screened tobacco use adolescents screened physician predominantly female white late adolescence covered private health insurance screening tobacco use highly correlated physician advice quit smoking controlling sociodemographic characteristics cigarette use relationship attenuated remained significant screening alcohol marijuana added model hispanic adolescents significantly less likely receive physician advice quit multivariable models conclusions findings suggest missed opportunities youth tobacco use prevention cessation efforts clinical setting research needed better facilitate open dialogue tobacco use physicians adolescent patients
background interleukin required helper cell responses production hepatitis virus infection previous study showed axis aggravates immune injury patients chronic hepatitis virus infection however role acute liver injury remains unclear objective purpose study determine role inflammatory cytokine lipopolysaccharide galactosamine lps galn induced acute liver injury mice methods serum patients chronic hepatitis virus chb acute chronic liver failure aclf healthy individuals served healthy controls hcs measured elisa neutralizing antibody neutralizing antibody administered intravenously time challenge lps galn cbl mice hepatic pathology expression related cytokines including tnf alpha neutrophil chemoattractants including cxcl cxd cxcl cxcl stabilization factor csf assessed liver tissue results serum significantly upregulated aclf patients compared chb patients hcs serum significantly upregulated non survival group compared survival group aclf patients consistent lps galn induced acute hepatic injury mice moreover treatment serum downregulated survival group aclf patients compared lps galn mice mice treated either neutralizing antibody neutralizing antibody showed less severe liver tissue histopathology significant reductions expression related inflammatory cytokine including tnf alpha neutrophil chemoattractants including cxcl cxcl cxcl cxcl stabilization factors csf within liver tissue compared lps galn mice conclusion high serum associated mortality aclf patients lps galn induced acute liver injury mice neutralizing antibodies attenuated liver injury reducing expression related inflammatory cytoldnes neutrophil chemoattractants stabilization factors within liver tissue indicated likely functions upstream related cytokine chemokine expression recruit inflammatory cells liver elsevier rights reserved
background intermittent parathyroid hormone pth used treat osteoporosis spine hip however whether used treat osteoporosis mandible unclear purpose study explore influence applying intermittent pth ovariectomized rats trabecular bone microarchitecture mandible femoral head methods eighteen female rats divided three groups healthy group ovariectomized ovx group ovx pth group ovx group ovx pth group ovx weeks age ovx pth group received intermittent pth therapy weeks mandibles femurs rats removed weeks scanned using microcomputed tomography micro results micro analysis trabecular bone microarchitecture mandible femoral head offered follows bone volume fraction trabecular thickness ovx group lower healthy group bone volume fraction trabecular thickness ovx pth group approximated healthy group conclusion conclusions study regarding trabecular bone microarchitecture mandible femoral head offered follows tbth ovx group lower healthy group tbth ovx pth group approximated healthy group therefore intermittent pth displayed high efficacy treating femoral mandibular deterioration bone microstructure resulting loss ovarian function osteoporosis femur mandible rats ameliorated intermittent pth therapy
background internal hip abduction moment major indicator hip loading new hip bracing concept designed unload cartilaginous area hip osteoarthritis via abduction external rotation force intended alter weight bearing area reduce compression joint objective assess effect novel brace hip rotation transverse coronal planes hip abduction moment study design repeated measures methods gait analysis performed subjects unilateral symptomatic hip osteoarthritis pain joint motion moments vertical ground reaction force compared braced unbraced control randomly assigned conditions results nine participants felt immediate reduction pain walking hip brace peak hip abduction moment significantly decreased osteoarthritis side peak hip adduction internal rotation angles significantly decreased stance brace conclusion wearing brace would appear reduce compressive joint reaction force femuroacetabular interface indicated reduction internal hip abduction moment along immediate pain reduction nine participants long term studies warranted
background internal medicine residents expected able provide gender specific care objective study develop consensus list core topics procedural skills women health allow residency program directors prioritize standardize educational efforts women health methods conducted two round delphi women health experts participants given list topics asked rank topic based important felt topic internal medicine residents proficient upon graduation identify topics critical women health curriculum mean importance ratings topics mean agreement ratings critical topics calculated list critical topics mirrored list important topics therefore consensus list included topic received mean importance rating results experts invited participate completed first round completing second round majority topics received importance rating highest ranking topics included cervical cancer screening screening osteoporosis diagnosis sexually transmitted infections mean rating highly rated topics included related contraception reproductive planning breast disease menopause performing breast pelvic examinations diagnosis gender specific conditions generally rated important management conditions addition pregnancy related topics overall deemed less important internal medicine training conclusion study generated consensus list core topics women heath serve guide residency programs development women health curricula
background isotretinoin systemic retinoid used treat acne binds receptors member steroid thyroid hormone superfamily certain types retinoids may cause abnormalities serum thyroid function tests stfts suppressing thyroid stimulating hormone tsh however uncertain whether systemic isotretinoin effect stfts objective aim study find alteration stfts patients acne vulgaris treated systemic isotretinoin methods total patients male female severe acne vulgaris treated total dose isotretinoin included study prospectively serum free free tsh levels measured baseline months treatment results mean serum tsh levels baseline months treatment uiu respectively mean serum tsh levels increased significantly following isotretinoin therapy respectively mean serum levels baseline months treatment pmol respectively mean serum levels baseline months treatment pmol respectively mean serum levels decreased significantly months compared baseline levels respectively conclusion systemic isotretinoin therapy causes significant alterations stfts dose dependent long term effects systemic isotretinoin stfts needs evaluation
background denied many improvements female child health achieved worldwide international family planning programs half females unintended pregnancy admitted used birth control month conception objectives aim study promote family planning practice among females zahedan southeast iran transtheoretical model ttm patients methods current quasi experimental study conducted eligible females allocated either case control group selected homes border zahedan city southeast iran convenience sampling door door visits used finding eligible cases attm based self administrated family planning questionnaire used data collection participants intervention group received education two groups based stage change precontemplation contemplation preparation action maintenance groups followed three months results result chi square test significant difference stage change precontemplation contemplation preparation action maintenance education control intervention groups education subjects intervention group moved forward stage change got least one step closer family planning behavior change significant movement participants stage change significant control group results statistical tests illustrated mean knowledge intervention group versus control group mean attitude intervention group versus control group practicing family planning methods intervention group higher control group education based ttm conclusions according study educational plan based ttm effective changing knowledge attitude practice directing females towards taking action moreover self efficacy perceived barriers benefits factors affect use family planning methods
background suggested probiotics may improve gastrointestinal discomfort probiotics exhibit effects consequently meta analyses probiotics confined well defined strains strain combinations aim study evaluate effectiveness probiotic fermented milk pfm includes bifidobacterium lactis lactis cncm lactic acid bacteria gastrointestinal discomfort general adult population methods double blind randomized controlled trials general adult population comparing pfm control dairy product least weeks searched multiple literature databases february meta analyses using random effects models individual participant data undertaken calculate odds ratio standard mean difference smd confidence interval results search strategy identified documents overall three trials total adults female met inclusion criteria consumption pfm product associated significant improvement overall gastrointestinal discomfort compared control product number needed treat nnt pfm also superior control reducing digestive symptoms measured using composite score smd sensitivity analyses produced similar results heterogeneity studies minimal conclusions meta analysis shows consumption pfm lactis cncm lactic acid bacteria associated modest consistent significant improvement outcomes related gastrointestinal discomfort healthy adults
background assumed beside alterations filaggrin gene flg disturbances within genes encoding cornified envelope proteins also involved atopic dermatitis identify new potential markers studied polymorphisms genes encoding repetin rptn cornulin crnn expression skin patients methods polymorphisms crnn rptn flg mutations analyzed taqman genotyping assay pcr rflp blood samples patients healthy subjects expression levels crnn rptn determined qrt pcr skin samples lesional nonlesional skin biopsies healthy volunteers patients recruited clinic university hospital results crnn allele associated severe course disease elevated ige levels eosinophilia concomitant asthma mrna level crnn decreased skin patients without flg mutations genotype rptn associated early age onset pruritus severity concomitant asthma elevated mrna levels rptn lesional nonlesional skin observed conclusions single nucleotide polymorphisms crnn rptn may contribute development studies larger group patients needed verify assumption karger basel
background unclear interventions effective improving medication adherence individuals serious persistent mental illness goal systematic review synthesize evidence examining effectiveness harms costs interventions improve medication adherence patients psychotic spectrum disorders bipolar disorder methods conducted systematic search several electronic databases january using structured search strategy studies included involved adult patients general mental health settings reported measures medication adherence clinical outcomes sufficient methodological rigor studies quality assessed synthesized using established methods results idented studies met inclusion criteria overall studies addressed interventions patients psychotic spectrum disorders interventions varied widely generally mixed findings contributing low insufficient strength evidence studies involving family members technology interventions consistently associated positive effect however strength evidence low intervention heterogeneity evidence insufficient determine effectiveness interventions patients bipolar disorder conclusions individuals psychotic spectrum disorders interventions family members technology consistent positive effect adherence although replication objective adherence measures along evaluation harms costs needed insufficient evidence draw conclusions interventions individuals bipolar disorder
background unclear whether health related quality life hrql may predictive value mortality idiopathic pulmonary fibrosis ipf investigated relationship hrql assessed using george respiratory questionnaire sgrq survival time patients ipf tried determine clinical meaningful cut value predict poorer survival rates methods retrospectively analyzed consecutive patients ipf underwent initial evaluation may december diagnosis ipf made according international consensus guidelines used cox proportional hazard models identify independent predictors mortality rate patients ipf results examined eligible cases average age years old male mean levels percent predicted fvc dlco six minute walk test distance sgrq total score around points multivariate analysis sgrq total score hazard ratio confidence interval percent predicted fvc independent predictors mortality rate moreover score higher points sgrq total score showed higher mortality rate conclusions sgrq total score one independent prognostic factors patients ipf total scores higher points associated higher mortality rates
background widely accepted excessive drinking contributes health social problems considerable interest potential community pharmacies setting health advice evidence suggests interventions pharmacists effective research interventions relating alcohol consumption primary care focused general practice although evidence exists efficacy pharmacy interventions little research date taken place aim study evaluate acceptability alcohol screening brief interventions women accessing emergency hormonal contraception ehc community pharmacies methods initiative whereby women accessed community pharmacies ehc would asked complete audit questionnaire following ehc consultation introduced primary care trust pct north east england evaluation incorporated three strands interviewing pharmacists implementation acceptability initiative interviewing clients identified low risk understand perceptions initiative conducting online follow surveys clients risky group evaluate impact initiative alcohol consumption contraceptive behaviour well perceptions service results pharmacists attitudes towards screening generally positive although organisational obstacles providing service felt uncertain engaging clients conversation sensitive topic however clients report feeling embarrassed upset happy talk pharmacist given advice clients felt pharmacist appropriate person carry alcohol screening advice conclusions feasible pharmacists carry screening brief advice customers find acceptable however pharmacist take service participation study low pharmacists enthusiastic providing screening health promotion services targeting different population groups alcohol screening may successful delivery audit tool pharmacists may obtain reliable responses specific client groups
background japanese encephalitis virus jev mosquito borne flavivirus causes japanese encephalitis acute encephalitis syndrome aes humans genotype circulating cases genotype iii isolated jev jev jev midnapur district west bengal first time clinical patients previously vaccinated live attenuated strain apply bioinformatics immunoinformatics sequence structure protein analysis crucial substitutions might cause genotypic transition affecting protein function altering specificity epitopes results although frequency substitutions glycoprotein jev jev jev isolates vary homologous patterns remain exactly similar earlier japan isolate ishikawa sequence model structure based analyses protein show four substitutions critical genotype specific effect common among isolates indicating role transition genotype iii genotype predicted cell cell epitopes seen harbor critical substitutions affect overall conformational stability protein epitopes subjected conservation analyses using large set protein asian continent conclusions study identifies crucial substitutions contribute emergence genotype predicted epitopes harboring substitutions may alter specificity might reason reported failure vaccine conservation analysis epitopes would useful design genotype specific vaccine
background joint pain including back pain arthritis common conditions united states affecting million individuals costing upwards billion year although activity limitations associated disorders impose substantial economic burden relationship explored large cohort methods study used medical expenditures panel survey investigate whether functional limitations explain difference medical expenditures patients arthritis joint pain without used sequential explanatory linear models investigate relationship accounted various covariates results unadjusted mean expenditures joint pain arthritis compared without fully adjusted model accounting also functional limitations joint pain arthritis paid without statistically significant difference conclusions growing economic public health burden arthritis joint pain well corresponding complications functional activity sensory limitations calls interdisciplinary approach heightened awareness among providers identify strategies meet needs high risk patients order prevent delay disease progression
background laboratory examination great value confirm diagnosis estimate disease activity rheumatoid arthritis ankylosing spondylitis since little research related diagnosis done iran aim present study evaluate diagnosis markers patients methods study conducted among patients patients iran inclusion criteria according american college rheumatology acr european league rheumatism eular criteria five blood samples collected patients laboratory studies consisted esr anti ccp tests also determination presence crp patients finally statistical analysis test conducted using spss version results study patients included males females average age patients positive negative also crp positive negative mean esr patients hour mean levels anti ccp mean ages patients including male females years among patients positive crp patients negative patients positive patients positive hla patients negative mean levels esr patients hour conclusions early diagnosis rheumatoid arthritis ankylosing spondylitis help prevent complications progression help patients recover quickly
background lack information described major factor non use oral emergency contraception following unprotected intercourse despite ongoing vociferous debate liberalisation access little evidence available knowledge germany particularly among adolescents methods conducted cross sectional survey among ninth graders convenience sample berlin schools assessed perceived actual knowledge effectiveness timeframe availability pregnancy risk six scenarios results total students years age participated mean age years standard deviation participants male whilst never heard knew effectiveness knew timeframe sources gynaecologists widely known students correctly evaluated pregnancy risk given scenarios girls knowledgeable topics except pregnancy risk attending school lower academic standard immigrant background associated lower knowledge majority items conclusions generally students aware existence many lacked knowledge take access especially light recent liberalisation access germany increased educational efforts warranted ensure population knowledge necessary make truly informed choice regarding use
background little known care management foreign patients pediatric oncology european centers aimed describe care given children adolescents young adults came france cancer treatment determine whether geographical origin influence decision making procedure conducted monocentric retrospective study foreign patients aged years hospitalized least one night institut curie paris france analyzed potential advantages receiving treatment france well social familial consequences results total foreign patients files retrieved patients came africa accord specific expertise institution retinoblastoma frequent tumor type antitumor treatment already administrated native country patients considered patients received significant medical advantage care institution treatment provided france considered impossible native country cases social familial impact patients families high almost patients received treatment would proposed french counterparts conclusions notable medical advantages foreign patients come france oncologic treatment despite important familial consequences patients geographical origin influence medical decisions
background little known drug use patterns among people living hiv comparison uninfected group general population aim study investigate association legal illegal drug use hiv infection nationally representative sample adults united states methods public use data files national survey drug use health nsduh used respondents asked whether medical professional ever told hiv aids ever lifetime past year past month use cigarettes alcohol marijuana cocaine heroin hallucinogens inhalants nonmedical use psychotherapeutics assessed logistic regression used estimate adjusted odds ratios aor relationship drug use hiv infection adjusting demographics results respondents age older categorized hiv infected ever use cigarettes tobacco marijuana cocaine heroin hallucinogens inhalants psychotherapeutics higher hiv infected individuals compared hiv uninfected individuals adjustment sex age race ethnicity education total family income marital status past year past month use also higher hiv infected individuals substances aside alcohol conclusions nationally representative sample higher levels drug use dsm dependence among hiv infected population compared hiv uninfected population concern drug use dependence impede engagement hiv care adherence antiretroviral therapy elsevier ltd rights reserved
background longitudinal patient centered care represents challenge general practitioners gps context reminder systems offer targeted support study aimed identify details reminders contents care addressed mode display electronic health record ehr visual appearance personnel responsibilities editing applying reminders use reminders patient recall methods mixed methods study comprised cross sectional survey among practices german university network structured observations reminder utilization six practices based clinical vignette describing multimorbid senior care needs descriptive statistics performed survey data practice observations analyzed portraying different types reminders results seventy three practices completed survey reported using reminders ehr frequent care contents addressed allergies adverse drug events preventive measures participation disease management programs chronic diseases upcoming vaccinations practice observations showed variety mainly self configured reminders patients ehr information displayed compiled separate field scattered throughout ehr pop window visual appearance electronic reminders varied colored fields short text ehr entries billing codes pre defined colors abbreviations within treatment documentation symbols within treatment documentation symbols linked free text fields traffic light schemes five practices self designed reminders needed one practice applied ehr embedded pre defined reminder system practices used reminders mean aspects care detailed clinical vignette range standard deviation practices needed min mean retrieve information requested conclusions practices use self designed visual reminders aspects care yet data based sophisticated solutions needed improve longitudinal care
background low testosterone levels associated coronary heart disease chd morbidity mortality men influence hormones postmenopausal women unclear meta analysis aimed examine whether association endogenous sex hormones chd risk postmenopausal women methods systematic search pubmed embase databases november performed prospective studies reported association endogenous sex hormones chd postmenopausal women summary relative risks rrs confidence intervals cis combined using random effects model results total publications studies including six prospective cohort six nested case control studies included summary rrs chd comparing highest versus lowest tertile total testosterone evidence high heterogeneity subgroup meta regression analyses none variables identified contributing significant heterogeneity based comparison highest versus lowest tertile models summary rrs cis chd free testosterone estradiol sex hormone binding globulin dehydroepiandrosterone conclusion limited evidence suggest endogenous levels sex hormones significantly associated chd risk postmenopausal women
background low testosterone acute chronic stress hypercoagulation associated hypertension hypertension related diseases interaction factors future risk coronary artery disease africans fully elucidated study associations testosterone acute cardiovascular coagulation stress responses fibrinogen von willebrand factor african caucasian men south african cohort investigated methods cardiovascular variables studied means beat beat ambulatory blood pressure monitoring fasting serum salivary testosterone citrate coagulation markers obtained venous blood samples acute mental stress responses evoked stroop test results african group demonstrated higher cardiovascular risk compared caucasianmen elevated blood pressure low grade inflammation chronic hyperglycemia hbac lower testosterone levels elevated vonwillebrand factor vwf fibrinogen levels blunted testosterone acutemental stress responses demonstrated african males multiple regression analyses higher circulating levels fibrinogen vwf africans associated low environment circulating fibrinogen caucasians regarding endothelial function low testosterone environment profile augmented alpha adrenergic acute mental stress responses diastolic dimer testosterone associated circulating vwf levels africans adj conclusions interdependence acute mental stress salivary testosterone dimer vascular responses existed african males association circulating vwf interdependence independent variables occurred fibrinogen levels elsevier ireland ltd rights reserved
background maladaptive emotional control defining feature personality disorders yet little known underlying physiological dynamics emotional reactivity psychosocial stress across distinct personality disorders current study compared subjective emotional responses autonomic nervous system hpa axis physiological responses psychosocial stress women cluster personality disorder cpd borderline personality disorder bpd methods subjective mood ratings salivary cortisol heart rate skin conductance level scl assessed exposure standardized psychosocial stress paradigm trier social stress test tsst women bpd women cpd healthy female controls subjects free medication including hormonal contraceptives regular menstrual cycle tested luteal phase menstrual cycle results cpd bpd patients reported similar burden subjective mood disturbance however bpd patients demonstrated reduced baseline cortisol levels blunted cortisol reactivity tsst addition bpd patients exhibited generalized increase scl significant differences baseline tsst reactivity cortisol scl observed cpd patients healthy controls conclusion findings indicate patients bpd significant alterations physiological stress reactivity notably distinct patients cpd healthy controls elsevier ltd rights reserved
background malignant pleural effusion mpe common complication advanced malignancy little known regarding prevalence overall burden population level methods conducted retrospective analysis mpe associated hospitalizations using healthcare cost utilization project nationwide inpatient sample agency healthcare research quality hcup nis cases included mpe coded primary secondary diagnosis unspecified pleural effusion coded addition diagnosis cancer either primary diagnosis results weighted sample admissions mpe identified among weighted admissions included database admissions female patients median age admission years interquartile range iqr years lung breast hematologic tract gynecologic cancers common primary malignancies associated mpe median length stay days iqr days inpatient mortality rate median hospitalization total charges iqr multivariate analyses female sex large fringe county residential area medicare insurance elective type admission independently associated lower risk inpatient mortality conclusions considerable inpatient burden high inpatient mortality associated mpe united states potential demographic geographic socioeconomic disparities
background many countries recently expanded childhood immunisation programmes schools increasingly attractive setting delivery new immunisations ability reach large numbers children short period time however organisational challenges delivery large scale vaccination programmes schools understanding facilitators barriers important improving delivery future school based vaccination programmes methods undertook systematic review evidence school based vaccination programmes order understand influence organisational factors delivery programmes eligibility criteria studies focused childhood adolescent vaccination programmes delivered schools considered organisational factors influenced preparation delivery programmes conducted developed high income country peer reviewed searched articles published english using medline hmic electronic databases additional studies identified searching cochrane library bibliographies extracted data studies assessed quality risk bias categorised findings using thematic framework eight organisational factors results found recent published literature united states concerned delivery pandemic seasonal flu vaccination programmes regional state local level found literature largely descriptive informed use theory despite identified common factors influence implementation programmes factors included programme leadership governance organisational models institutional relationships workforce capacity roles particularly concerning school nurse communication parents students including methods obtaining consent clinic organisation delivery conclusions first time information brought together organisational factors influencing delivery vaccination programmes school based settings understanding factors underpinned robust theory informed research may help policy makers managers design deliver better programmes identified several gaps research literature propose future research agenda informed theories implementation organisational change
background many obstacles obtaining psychotherapy continue diminish reach despite documented positive effects using short message service sms texting web platforms enable licensed psychotherapists deliver therapy directly lived context client one possible solution introduction employing feasibility study design pilot trial evaluated external validity treatment outcomes text therapy extended findings include mobile enabled text platforms materials methods adults seeking text therapy treatment variety disorders recruited text therapy service clinical outcomes measured using general health questionnaire ghq weeks treatment process variable therapeutic alliance measured working alliance inventory treatment acceptability assessed ratings satisfaction several aspects treatment including affordability effectiveness convenience wait times receiving treatment cost effectiveness results results indicate evidence effectiveness intervention ghq cohen twenty five participants experienced clinically significant symptom remission therapeutic alliance scores lower found traditional treatment settings still predicted symptom improvement high levels satisfaction text therapy reported dimensions affordability convenience effectiveness cost effectiveness analyses suggest text therapy cost traditional services offers much reduced wait times conclusion mobile enabled asynchronous text therapy licensed therapist acceptable clinically beneficial medium individuals various diagnoses histories psychological distress
background many patients bipolar disorder experience residual symptoms inter episodic periods study aimed analyse relationship residual depressive symptoms sleep disturbances self reported cognitive impairment determinants psychosocial functioning large sample euthymic patients methods cross sectional study euthymic outpatients evaluated residual depressive symptoms bipolar depression rating scale sleep disturbances pittsburgh sleep quality index perceived cognitive performance using visual analogic scales functioning functioning assessment short test structural equation modelling sem used describe relationships among residual depressive symptoms sleep disturbances perceived cognitive performance functioning results sem showed good fit normed chi square comparative fit index root mean square error approximation standardized root mean square residuals model revealed residual depressive symptoms path coefficient perceived cognitive performance path coefficient important features significantly related psychosocial functioning sleep disturbances indirectly associated functioning via residual depressive symptoms perceived cognitive performance path coefficient conclusions study contributes better understanding determinants psychosocial functioning inter episodic periods patients findings facilitate decision making therapeutics improve functional outcomes period
background many placebo controlled studies demonstrated allergen immunotherapy ait effective therapy treating allergies commonly used routes subcutaneous scit sublingual immunotherapy slit require high patient adherence successful literature numbers describing adherence vary widely investigation compares two routes therapy directly methods data retrieved patient data management system center dermatology specific allergology environmental medicine germany patients aged years included study commenced ait thus allowing full year ait cycle considered investigated patient results specific center scit prescribed slit included patients total dropout rate whole patient cohort overall slit patients showed higher dropout rate scit patients however difference groups significant also significant difference overall dropout rates men women observed kaplan meier curve patient collective showed remarkably high dropout rate first year therapy conclusion analysis presented single center study shows patients discontinue ait first year therapy patients seem likely finish year therapy cycle manage adhere treatment throughout first year strategies preventing nonadherence ait therefore need developed standardized future investigations
background many studies indicated immune dysfunction might involved physiopathology schizophrenia aggression study aimed investigate correlation high sensitivity reactive protein hscrp interleukin clinical characteristics especially aggression explore potential role hscrp plasma biomarkers schizophrenia methods forty one patients schizophrenia forty healthy individuals enrolled psychopathological severity aggression assessed using positive negative syndrome scale panss modified overt aggression scale moas plasma concentrations hscrp assessed enzyme linked immunosorbent assay elisa results higher levels hscrp lower levels logil higher ratio hscrp observed plasma patients schizophrenia compared healthy controls roc receiver operating characteristic curve analysis revealed ratio hscrp predictive value sensitivity specificity applicable biomarker distinguish patients schizophrenia control group hscrp alone predictive value respectively found positive correlations hscrp total score verbal aggression score moas hscrp total score moas conclusions results suggest possible function hscrp pathogenesis schizophrenia possible value hscrp potential peripheral biomarker schizophrenia finding also suggests relationship hscrp ratio aggression patients schizophrenia elsevier rights reserved
background martial arts judo taekwondo wrestling regulated usually athletic duels aim score better opponent win type sport athletes martial arts sustain minor major injuries may many negative consequences addition sports injuries rehabilitation generate high costs healthcare system contrast fifa warm program preventive programs postulated injury prevention martial arts therefore aim systematic review summarise latest research findings evaluate whether initial recommendations given reduction injuries martial arts judo wrestling taekwondo methods gain overview latest research findings searched systematic reviews pedro pubmed cochrane internet search engine google scholar methodological quality reviews assessed using critical appraisal tool systematic review casp data extracted risk injury injury location injury type results found three review articles low moderate methodological quality regarding injury location became evident extremities particularly vulnerable injury three martial arts effusion observed common type injury conclusion due moderate methodological quality injury type effusion possible formulate recommendations injury prevention moreover uniform definitions developed describe sports injuries
background maternal allergic disease history impaired regulatory cells tregs critical risk factors allergy development children however mechanisms underlie risk factors remain poorly defined therefore aim study assess whether maternal allergies affect tregs offspring lead allergy development childhood methods total mothers healthy newborns allergic mothers allergic mothers recruited study detailed questionnaires administered yearly determine allergy status mothers newborns birth years age cord blood samples obtained time birth analysed treg counts well treg activity based response toll like receptor tlr stimuli lipid lpa peptidoglycans ppg surface markers associated genes suppressive capacity cytokine levels tregs also measured possible correlations treg activity maternal neonate allergies assessed addition environmental microbial content known risk factors allergies measured results cord blood mononuclear cells cbmcs offspring allergic mothers showed fewer foxp cells lower expression levels associated genes reduced cytokine production interleukin interferon gamma especially via ppg tlr pathway suppression effector cells tregs children mothers allergies impaired especially production type helper cells children developed allergies first years life lower numbers foxp cells reduced foxp expression production newborns maternal allergic background identified risk factor allergy development children odds ratio declining treg numbers production foxp expression neonates ppg lpa stimulated identified independent risk factors allergic diseases offspring years age adjusting maternal allergic history environmental factors conclusion maternal allergy correlated impaired tregs neonates could enhance susceptibility offspring allergic diseases early childhood due imbalance cells
background maternal education influences skeletal growth offspring adult blood pressure height components negatively associated high income countries aim evaluate association maternal education offspring adult systolic diastolic sbp dbp assessing whether different height components might mediate association subjects methods simple mediation modelling used evaluate maternal education offspring sbp dbp association estimating contribution offspring height components cross sectional sample brazilians aged elsa brasil study results full adjustment confounders compared participants whose mothers received low education whose mothers received high education average lower sbp result link maternal education offspring adult height turn influenced sbp thus maternal education sbp association occurred indirectly height trunk leg length alternatively conclusions better maternal education might influence higher leg trunk lengths offspring turn might contribute prevent higher adults negative height association reported high income countries also present middle income country recent economic development
background medial ulnar collateral ligament ucl injuries elbow require surgical management uncommon growing evidence however suggesting incidence ucl reconstruction uclr procedures rapidly increasing sought quantify incidence age related trends uclr subsequently project future trends hypothesized total number uclrs performed increased disproportionate incidence among younger patients would observed methods new york state statewide planning research cooperative system database queried identify individuals years old undergoing uclr poisson regression used develop future projections uclr new york state population incidence estimates per people calculated results new york state patients underwent uclr average annual incidence per people equaling ages years significantly greater age groups projections suggest incidence year olds year olds continue rapidly increase rates age groups remain relatively stable conclusions number uclrs performed increased disproportionate trend average annual incidence patients years old observed review literature questioned outcomes adolescent athletes uclr continued attempts preventing injuries young throwing athlete remain paramount journal shoulder elbow surgery board trustees
background menarche age associated inconsistently occurrence timing severity major depressive disorder mdd rarely studied women bipolar bds anxiety disorders methods investigated women patients sardinian mood disorder center associations age menarche age illness onset major affective anxiety disorders year birth selected factors using bivariate comparisons multivariate regression modeling results among women dsm mdd anxiety disorders born mean age years menarche age averaged years illness onset age averaged years ranking anxiety disorders mdd years menarche age declined secularly birth years associated younger illness onset fewer siblings psychiatrically ill first degree relatives living rural environments suicidal substance abuse unemployed earlier menarche earlier illness onset significantly associated onset age groups years menarche age versus diagnosis ranked anxiety disorders mod conclusions age menarche sardinia elsewhere declined past decades strongly associated age onset bipolar anxiety well major depressive disorders across age range suggesting sustained effects biological maturational factors elsevier masson sas rights reserved
background meniscal root tears cause menisci insertions inadequately distribute loads potentially leave underlying articular cartilage unprotected untreated meniscal root tears becoming increasingly recognized induce joint degradation however little information known anterior meniscal root tears affect joint tissue purpose observe early degenerative changes within synovial fluid menisci tibial articular cartilage subchondral bone arthroscopic creation untreated anterior meniscal root tears study design controlled laboratory study methods anterolateral meniscal root tears created knee joint adult flemish giant rabbits anteromedial meniscal root tears created additional rabbits contralateral limbs used nonoperated controls animals euthanized weeks postoperatively synovial fluid aspirated tissue samples menisci tibial articular cartilage collected processed multiple analyses detect signs early degeneration results significant changes found within synovial fluid meniscal tissue tibial subchondral bone knees anterior meniscal root tears compared controls significant changes identified tibial articular cartilage comparing tear groups controls conclusion study demonstrated early degenerative changes within synovial fluid menisci tibial subchondral bone leaving anterior meniscal root tears untreated weeks results suggest meniscal tissue presents measurable degenerative changes prior changes within articular cartilage anterior meniscal root tears anterior destabilization meniscus arthroscopically may lead measurable degenerative changes useful future vivo natural history animal repair studies clinical relevance present study first investigate various tissue changes anterior meniscal root tears medial lateral menisci results study suggest degenerative changes occur within synovial fluid meniscus tibial subchondral bone prior measurable changes tibial articular cartilage studies expand study evaluate components continue progress left untreated long periods
background menopause derived estrogen deprivation related endocrine factors linked symptoms typical middle aged women hot flashes aches joint pain stiffness depressed mood bone degeneration nutritional dysfunction difficulty maintain body mass clinical approaches problems often involve hormone replacement therapy modalities therapeutic intervention however well known side effects associated pharmacological alternatives led physicians patients pursue new strategies alleviate symptoms physiological state first recommended option natural healthy therapy alone combination pharmacotherapy severe cases among natural alternatives mhk nutraceutical lipoprotein extracted mytilus galloprovincialis found beneficial properties methods reviewed numerous high impact references show controversies current treatments used alleviate menopausal symptoms presented results obtained mhk good natural alternative results mhk showed positive effects hot flashes mood swings joint pain bone stability associated glucosamine related anti inflammatory effect high content vitamins minerals iron substances selenium vitamin significant increase serum growth hormone mediated hepatic secretion insulin growth factor slight decrease bone alkaline phosphatase calcium similar crosslaps concentrations contribute beneficial impact bone turnover mhk also showed powerful antioxidant effect increase iron stores particular importance women low basal ferritin levels conclusion findings review confirm efficiency natural therapies menopause symptoms emhk healthy choice inclusion clinical practice
background mental health services mhs use complex behaviour concern individuals current mental disorder date studies examined age related contextualisation mhs use reasons seeking help may vary according development stages adulthood aims study aimed determine predisposing enabling need factors using andersen model associated mhs use according adult development stages among individuals without current psychiatric diagnosis methods three age groups examined year olds year olds year olds data obtained montreal longitudinal catchment area study bivariate multivariate logistic regression analyses conducted age group separately determine predisposing enabling need factors associated mhs use past months results year olds one enabling factor internet search two need factors presence major depressive disorder number stressful events positively associated mhs use year olds one predisposing factor family history mental disorder four enabling factors currently working school perceiving neighbourhood disorder social cohesion internet searching one need factor major depressive disorder correlated help seeking year olds two predisposing factors family history mental disorder higher self perceived stigma two enabling factors low satisfaction personal relationship internet searching one need factor alcohol dependence associated mhs use conclusions factors associated mhs use differ according adult development stages programmes policies based age related contextualisation increase mhs use
background mental health related stigma major public health issue obstacle possibility successful treatment recovery reintegration aim examine attitudes towards mental illness among employees social services methods study design part large randomized trial data presented study baseline data trial respondents completed baseline questionnaire assess respondents attitudes results significant difference found employees personal attitudes towards depression schizophrenia significant difference found employees perceived attitudes furthermore significant difference found employees personal perceived attitudes significant difference found respondents wish social distance towards depression schizophrenia cases except regarding willingness provide job one workplace conclusion employees social services comparable general public concerning attitudes towards mental illness implications results indicate employees social services could great use gaining knowledge mental illness ways recognize mental illness order able offer right kind help reduce treatment gap concerning people suffering mental illness
background mesothelioma resistant conventional treatments often defective pathways examined anti tumor effects metformin agent type diabetes combinatory effects metformin nutlin inhibitor ubiquitin mediated degradation human mesothelioma methods examined effects colorimetric assay cell cycle analyses investigated molecular events cells treated metformin nutlin western blot analyses involvement tested sirna results metformin suppressed cell growth kinds mesothelioma including immortalized cells mesothelium origin irrespective functional status whereas susceptibility nutlin partly dependent genotype investigated combinatory effects metformin nutlin nutlin sensitive msto nci cells insensitive ehmes cells wild type gene knockdown expression sirna demonstrated susceptibility msto nci cells nutlin dependent whereas ehmes cells nevertheless cells treated agents produced additive synergistic growth inhibitory effects cell cycle analyses also showed combination increased sub fractions greater metformin nutlin alone msto ehmes cells western blot analyses showed metformin inhibited downstream pathways mammalian target rapamycin mtor activate pathways whereas nutlin phosphorylated suppressed mtor pathways cleaved caspase conversion lca also detected dependent cells treatments combination agents msto cells rather suppressed pathways activated nutrin treatments whereas combination rather augmented actions nci ehmes cells conclusion data collectively indicated possible interactions mtor pathways combinatory effects attributable differential mechanisms induced cross talk pathways
background metabolic syndrome one important health issues worldwide obesity causes insulin resistance hyperlipidemia diabetes various diseases throughout body liver phenotype called nonalcoholic steatohepatitis nash frequently progresses hepatocellular carcinoma recently established new animal model tsumura suzuki obese diabetic tsod mice spontaneously exhibit obesity diabetes hyperlipidemia nash liver nodules methods examined effects coffee intake various conditions metabolic syndrome using tsod mice daily volume coffee administered limited reflected appropriate quantities consumed humans clarify effects specific components animals divided two coffee intake groups included without caffeine results coffee intake significantly affect obesity hyperlipidemia tsod mice contrast coffee intake caused various degrees improvement pancreatic beta cell damage steatohepatitis liver carcinogenesis effects believed caused synergistic effect caffeine components polyphenols however antifibrotic effects coffee appeared due polyphenols rather caffeine conclusions daily habit drinking coffee could possibly play role prevention metabolic syndrome
background methods silico screening large databases molecules increasingly complement replace experimental techniques discover novel compounds combat diseases techniques become complex computationally costly faced increasing problem provide research community life sciences convenient tool high throughput virtual screening distributed computing resources results end recently integrated biophysics based drug screening program flexscreen service applicable large scale parallel screening reusable context scientific workflows conclusions implementation based pipeline pilot simple object access protocol provides easy use graphical user interface construct complex workflows executed distributed computing resources thus accelerating throughput several orders magnitude
background migraine debilitating neurological disorder trigeminovascular activation plays key role previously reported local application complete freund adjuvant cfa onto dura mater caused activation rat trigeminal ganglion abolished systemic administration kynurenic acid kyna derivate szr hypothesize activation may extend trigeminal complex brainstem attenuated treatment szr methods activation trigeminal nucleus caudalis tnc trigeminal tract achieved application cfa onto dural parietal surface szr given intraperitoneally one dose prior cfa deposition repeatedly daily days immunohistochemical studies performed mapping glutamate fos pacap substance beta tnf alpha tnc regions brainstem regions spinal cord results found cfa increased fos glutamate immunoreactivity tnc neurons effect mitigated szr pacap positive fibers detected fasciculus cuneatus gracilis substance tnfa beta immunopositivity detected fibers neither molecules showed change immunoreactivity following cfa administration conclusion first study demonstrating dural application cfa increases expression fos glutamate tnc neurons treatment kyna analogue prevented expression
background mitochondrial dysfunction oxidative stress main toxic events leading dopaminergic neuronal death parkinson disease identified vital objective therapeutic intercession study investigated neuro protective effects demethoxycurcumin dmc derivative curcumin rotenone induced neurotoxicity methods syy neuroblastoma cells divided four experimental groups untreated cells cells incubated rotenone cells treated dmc rotenone dmc alone treated treatment rotenone treatment dmc cell viability assessed using mtt assay levels ros mmp plus expression apoptotic protein analysed results rotenone induced cell death syy cells significantly reduced dmc pretreatment dose dependent manner indicating potent neuroprotective effects dmc rotenone treatment significantly increases levels ros loss mmp release cyt expression pro apoptotic markers decreases expression anti apoptotic markers conclusions even though results present study indicated dmc may serve potent therapeutic agent particularly treatment neurodegenerative diseases like pre clinical clinical studies required
background mobile phoned based interventions increasingly used clinical populations improve health health care delivery literature shown mobile phone based text messages short message service sms instantaneous cost effective less chance misplaced studies using mobile phone based text messages reported text messages effective reminders resulted increased appointment attendance adherence treatment better self management reports adverse events using text messaging terms misreading misinterpreting data transmitting inaccurate data losing verbal nonverbal communication cues privacy issues failure delay message delivery however literature cited need personalized messages responsive individual needs addition dearth information use reminders nonclinical populations objective goal study assess effectiveness adding reminders form text messaging versus reminder calls versus text messages reminder calls increase use service referrals provided community outreach methods total participants recruited study participant randomized one three arms group receives reminder calls callsonly group receives text message reminders textonly group receives reminder calls text messages calls text groups receive reminder intervention day baseline receive medical social service referrals community health workers chws standard script used administer call text reminders item telephone based satisfaction survey administered assess participant satisfaction process receiving periodic reminders results study recruitment follow phase authors anticipate completion recruitment interventions data entry july preliminary results expected available september conclusions study provide opportunity test effectiveness mobile based interventions nonclinical community recruited populations particular protocol would increase effectiveness community based engagement program instating formal reminder system program members receive social medical service referrals outreach community findings study would guide development implementation reminder protocols community based engagement programs nationwide
background monoamine oxidase inhibitors maois developed major depressive disorder alzheimer parkinson disease newer maois minimal sensitivity tyramine key limitation optimizing development standards vivo monoamine oxidase mao occupancy humans well established objectives determine dose occupancy relationship moclobemide occupancy phenelzine typical clinical dosing methods major depressive episode mde subjects underwent harmine positron emission tomography scanning prior following weeks treatment moclobemide phenelzine results mean brain mao occupancies moclobemide daily moclobemide daily phenelzine daily regional dose occupancy relationship moclobemide fit hyperbolic function mean mean multivariate analyses variance showed significantly greater occupancy phenelzine higher dose moclobemide compared lower dose moclobemide conclusions findings suggest first line mde treatment daily moclobemide doses correspond mao occupancy whereas treatment resistant mde either phenelzine higher doses moclobemide correspond mao occupancy least therefore novel mao inhibitor development aim similar thresholds findings provide rationale treatment algorithm design raise moclobemide doses inhibit mao sites suggest switching high dose moclobemide phenelzine best justified binding additional targets
background morbidly obese women increased risk breast cancer majority surgical weight loss patients older years old objective purpose present study determine technical interpretive changes mammography following bariatric surgery setting accredited academic hospital methods two breast imaging radiologists reviewed screening mammograms performed morbidly obese women undergoing bariatric surgery pre postoperatively american college radiology breast imaging reporting data system acr rads density imaging quality measurements compression force breast thickness pectoral nipple line pnl length ray beam kilovoltage kvp miliamperes per second mas recorded results average patient age years old mean age menarche years old patients postmenopausal average age years menopause family history breast cancer significant reduction bmi waist circumference following bariatric surgery significant reduction breast thickness reduction pnl length reduction kvp reduction mas even though compression force change pre postoperative mammograms detected breast densities fatty scattered though scattered fewer fatty images surgery conclusion morbidly obese women undergo quality mammograms bariatric surgery however weight loss bariatric surgery leads slightly denser mammograms furthermore weight loss reduces mammographic radiation doses american society metabolic bariatric surgery rights reserved
background children western populations meet recommendations fish consumption oily fish important source long chain polyunsaturated fatty acids lcpufa reduce blood pressure plasma triacylglycerol adults may affect cognitive development behavior however knowledge potential effects oily fish cardiometabolic health cognitive function behavior children investigated aim fisk junior study investigate effects oily fish consumption cardiovascular risk markers cognitive function behavior healthy children methods design conducting randomized controlled trial year old danish children comparing effect consuming week oily fish poultry control weeks august june primary outcomes blood pressure fasting plasma triacylglycerol measured baseline endpoint addition assess erythrocyte fatty acid composition compliance heart rate plasma cholesterol markers glucose homeostasis growth body composition dietary intake physical activity sleep also examine effects cognitive function attention memory executive functions using standardized tests behavior emotions administering parent rated questionnaires child interviews measure physiological stress response cortisol levels need children complete trial detect groups difference mmhg diastolic blood pressure mmol plasma triacylglycerol thus aim recruit children outcomes analyzed completer analysis supplemented sensitivity analyses primary outcomes attention given potential sex genotype specificity discussion results fisk junior study expected fill important gaps current knowledge importance dietary fish lcpufa children health development may used setting dietary recommendations
background countries started educate students special educational needs sen mainstream schools remains unclear inclusive attitudes towards students sen promoted aims study investigated role adolescents friendships socio moral competencies attitudes towards inclusion students sen specifically studied whether adolescents without sen would develop inclusive attitudes close friendships sen students expressed negative emotions social exclusion methods adolescents inclusive attitudes emotions gathered survey data swiss students aged social network data collected assess adolescents friendship relationships results results indicated adolescents friendship closeness sen students positively related inclusive attitudes however true adolescents anticipated negative positive emotions student sen excluded implications findings highlight role friendship relationships adolescents without sen adolescents socio moral experiences attitudes towards inclusion peers sen thus inclusive education may benefit promoting friendships among students without sen well adolescents sociomoral competencies elsevier ltd rights reserved
background particulate matter health studies children asthma use exposures averaged course day take account spatial temporal variability presumably occurs children move home transit school microenvironments objectives work identify increases morning exposure occurring within home transit school microenvironments determine associations asthma related inflammation rescue medication use methods thirty denver area schoolchildren asthma performed personal exposure monitoring using real time sensor integrated geographic information system gis apportion exposures home transit school microenvironments concurrently daily monitoring airway inflammatory biomarker urinary leukotriene ulte albuterol usage performed results mean exposures morning relatively well correlated microenvironments subject samples thus limiting use exposure metric attribute health effects exposure specific microenvironments within microenvironment increases exposure would characterized one series transient spikes sustained increase concentration exposure event however strongly correlated microenvironments vertical bar vertical bar exposure event transit demonstrated increase ulte increase albuterol usage compared days without transit exposure events associations exposure events health outcomes home school microenvironments tended positive well weaker transit conclusions school children asthma moving across morning microenvironments experience spatially heterogeneous exposures potentially varying health effects
background mothers motion mim community based lifestyle behavioral intervention designed conducted help low income overweight obese young mothers prevent weight gain via promotion stress management healthy eating physical activity paper presents intervention effect body weight primary outcome summarizes lessons learned methods participants recruited special supplemental nutrition program women infants children wic offices michigan individually randomized intervention comparison group ratio week intervention intervention participants watched theory based culturally sensitive videos dvd format featuring peers target audience learn skills managing stress eating healthier physically active also dialed peer support group teleconferences enhance skills learned videos increase motivation lifestyle behavioral changes body weight primary outcome measured baseline immediately week intervention months week intervention intervention effect tested via general linear mixed model repeated measures using baseline measures adjusting covariates results baseline mean age participants years intervention comparison mean body weight lbs intervention comparison mean body mass index bmi intervention comparison sample obese months week intervention significant weight differences found intervention lbs bmi comparison groups lbs bmi controlling baseline body weight conclusions lifestyle behavioral intervention focused stress management healthy eating physical activity effective helping low income overweight obese young mothers prevent weight gain
background multiple sclerosis autoimmune disorder common disease occurring central nervous system cns remyelination plays pivotal role alleviating neurological impairment catalpol effective component extracted chinese herb radix rehmanniae proved protective cerebral diseases methods determine protective effects mechanisms catalpol mice experimental autoimmune encephalomyelitis eae induced myelin oligodendrocyte glycoprotein mog model human cells counted flow cytometric fcm expressions nerve glial antigen myelin basic protein mbp measured immunohistochemical staining olig olig brdu cells counted immunofluorescence olig olig gene expressions detected real time fluorescent quantitative reverse transcription qrt pcr results results showed catalpol improved neurological function reduced inflammatory cell infiltration demyelination could decrease cells peripheral blood increased protein expressions mbp mice brains regulated markedly protein gene expressions olig olig terms timing site targets conclusions data demonstrated catalpol strong neuroprotective effect eae mice catalpol also plays role remyelination promoting expressions olig olig transcription factors
background myeloproliferative neoplasms mpn group blood cancers boost normal blood cell production bone marrow abnormal mutations stem cells found accompanying occurrence mpn shown mpl mutations mpl mpl involved patients mpn since tyrosine residues mediate normal mpl signaling whether affect mpl induced myeloproliferative neoplasms mpns unknown results study tested functions mpl induced myeloproliferative neoplasms mpns substituting either phenylalanine mpl termed mpl mpl mpl respectively vitro mpl mpl mpl retained ability induce tpo independent proliferation increase colony forming unit megakaryocytes cfu accordingly differential activation downstream signaling four mutants observed constitutively active stat akt instead stat partially compensated mpl function support stat deficiency impaired mpl induced cfu expansion vivo mpl mpl mpl induced typical features mpns high wbc platelet counts splenomegaly hepatomegaly hypercellularity bone marrow surprisingly mpl also caused hypercellularity bone marrow splenomegaly without significant features also observed differential effects four mutants progenitors myeloid cells megakaryocytes conclusions studies revealed distinct features tyrosine sites mediating mpl induced megakaryocyte hyperproliferation mpns study also suggests mpl cytosolic phosphorylated flanking amino acids could become targets pharmacologic inhibition mpns
background myeloproliferative neoplasms mpns group chronic hematologic malignancies carry significant physical psychological symptom burdens significantly affect patients quality life objectives sought identify relationship early childhood adversity eca psychological distress patients mpns eca may compound symptom burden methods patients mpns assessed eca risky families questionnaire subscales include abuselneglectichaotic home environment distress distress thermometer problem list anxiety hospital anxiety depression scale anxiety hads depression hospital anxiety depression scale depression hads meeting standardized cutoff thresholds distress distress thermometer problem list lanxiety hads ldepression hads demographic factors results total participants completed study response rate eca associated depression anxiety distress pmyelofibrosis essential thrombocythemia taking antidepressant conclusion eca associated psychological distress meets screening criteria anxiety depression patients mpns eca may help explain individual patient trajectories understanding may enhance patient centered care among patients mpns
background myogenesis positively regulated thyroid hormone triiodothyronine amplified type deiodinase activation thyroxine global inactivation dio gene impairs skeletal muscle skm differentiation regeneration response muscle injury given newborn adult mice late developmental skm dio disruption develop significant phenotype hypothesized plays early role process methods tested mice skm disruption dio driven two early developmental promoters myf myod results myf myoblasts culture differentiate normally myotubes despite loss almost activity dio mrna levels developing skm obtained myf dko embryos control littermates expression responsive genes myh atpa affected myf dko myod dko neonatal hind limb muscle expression myh atpa remained unaffected despite loss activity mrna myod dko neonatal muscle reduction atpa mrna postnatal growth mouse models skm function assessed exercise capacity measurement muscle strength normal furthermore analysis adult soleus revealed changes expression responsive genes except increase myod dko sol myh mrna conclusion two mouse models early developmental disruption dio myocyte precursor exhibit significant skm phenotype
background national working groups identify need return investment research conducted purchaser perspective however field developed standardized methods measuring basic components return investment including costing value work productivity loss due illness recent literature divided whether commonly used method underestimates overestimates loss goal manuscript characterize within variation cost work productivity loss illness estimated commonly used method two refinements methods one senior health benefit specialist companies employing workers completed cross sectional survey describing company size industry policies practices regarding work loss allowed research team derive variables needed estimate work productivity loss illness using three methods compensation estimates derived multiplying lost work hours presenteeism absenteeism wage fringe disruption correction adjusted estimate account worker disruption friction correction accounted labor substitution analysis compared bootstrapped means medians within three methods results average company realized annual per capita loss depression compensation methods loss disruption correction compared loss friction correction agreement across estimates conclusion although methods identify similar companies high costs lost productivity friction correction reduces size compensation estimates productivity loss one half analyzing potential consequences method selection dissemination interventions employers intervention developers encouraged include friction methods estimate economic value interventions designed improve absenteeism presenteeism business leaders industries labor substitution common encouraged seek friction corrected estimates return investment health policy analysts encouraged target dissemination productivity enhancing interventions employers high losses rather employers
background neonatal period one important critical phases humanlife intensive care unit stressful environment infant patient pressure factors noise nursing intervention harsh light important factor regard separation parents objectives study aimed investigate effect skin skin care fathers salivary cortisol infant methods study randomized clinical trial premature infants paired fathers neonatal intensive care unit nicu tabriz alzahra teaching hospital conducted november control group received standard care intervention group minutes skin skin care saliva samples collected infants intervention measure cortisol level spss statistical software used analyze data significance level results salivary cortisol babies control group mean value intervention group mean value conclusions groups showed decreasing cortisol levels study reduction skin skin care group control group significant difference thus making possible fathers take care infants effective helpful secure way
background next generation sequencing making critical robustly rapidly handle genomic ranges within standard pipelines standard use cases include annotating sequence ranges gene genomic annotation merging multiple experiments together subsequently quantifying visualizing overlap widely used tools tasks work command line bedtools small number available packages either slow distinct semantics features command line interfaces results provide robust based interface standard command line tools genomic coordinate manipulation created bedr open source package use either bedtools bedops back end performs data manipulation extremely quickly creating data structures readily interfaced existing computational pipelines includes data visualization capabilities number data access functions interface standard databases like ucsc cosmic conclusions bedr package provides open source solution enable genomic interval data manipulation restructuring programming language commonly used bioinformatics therefore would useful bioinformaticians genomic researchers
background nivolumab anti programmed cell death anti monoclonal antibody approved food drug administration treatment metastatic non small cell lung cancer metastatic melanoma relapsed hodgkin lymphoma advanced renal cell cancer report rare case myxedema crisis induced nivolumab patient metastatic squamous cell carcinoma lung case presentation fifty three year old woman metastatic squamous cell carcinoma currently treatment nivolumab presented diffuse facial tongue swelling slurred speech depressed mentation fatigue weakness initial evaluation revealed severe hypothyroidism thyroid stimulating hormone micro unit normal reference range micro unit undetectable free patient diagnosed nivolumab induced myxedema crisis treated successfully levothyroxine complete resolution symptoms nivolumab safely restarted symptoms myxedema resolved conclusion nivolumab cause immune mediated endocrinopathies including thyroiditis hypophysitis adrenal insufficiency type diabetes mellitus high index suspicion periodic measurement thyroid function tests recommended patients receiving nivolumab therapy case also suggests myxedema crisis treated symptoms resolved nivolumab safely challenged
background danish guidelines screening sexually transmitted infections stis women living hiv wlwh exist except annual syphilis testing drug drug interaction hormonal contraceptives types highly active antiretroviral therapy haart occurs assessed prevalence stis contraceptive choices predictors condom use cohort wlwh denmark methods wlwh consecutively enrolled outpatient visits gynaecological examination interview performed entry month follow inclusion criteria hiv infection years age exclusion criteria pregnancy alcohol drug abuse impeding adherence protocol entry participants tested appropriate treated according guidelines chlamydia trachomatis neisseria gonorrhoeae syphilis herpes simplex hsv hsv follow predictors condom use estimated sexually active wlwh results total eligible wlwh denmark included median age hiv duration years chlamydia trachomatis present four individuals six tested positive hsv pcr none positive neisseria gonorrhoeae hsv active syphilis follow participated sexually active contraceptives used condoms preferred hiv negative partner predicted condom use adjusted group participants reproductive age without pregnancy desires used birth control possible drug drug interaction hormonal contraceptives haart found wlwh receiving kinds medication conclusion prevalence stis wlwh denmark low need annual sti screening questionable condoms preferred contraceptives especially wlwh hiv negative partner cohort wlwh reproductive age risk unintended pregnancies due lack birth control finally subgroup wlwh receiving hormonal contraceptives haart possible drug drug interactions could occur
background systematic evaluations comprehensive clinical pharmacy process measures currently exist determine optimal ambulatory care collaboration model chronic obstructive pulmonary disease copd patients objective describe impact pharmacist provided clinical copd bundle management copd hospital based ambulatory care clinic methods retrospective cohort analysis evaluated patients copd managed outpatient pulmonary clinic primary objective study assess completion metrics known improve management copd medication therapy management quality measures including smoking cessation vaccines patient adherence patient education secondary objective evaluate impact clinical copd bundle clinical economic outcomes days post initial visit results total patients included study patients served controls patients received copd bundle clinical pharmacist patients control group metrics completed documented compared copd bundle group additionally statistically significant difference found metrics evaluated individually clinical pharmacy services reduced number phone call consults days statistically significant impact additional pre identified clinical outcomes conclusion pharmacist driven clinical copd bundle associated significant increases completion documentation metrics known improve outpatient management copd
background nonanesthetic colonoscopy popular clinical practice china however intestinal spasms often result prolonged examination time increased operating difficulties decreased polyp detection rate failure complete procedure clinically therefore exploring alternative approaches reduce pain patients colonoscopy utmost importance finding optimal preoperative administration improve quality nonanesthetic colonoscopy also necessary study aimed investigate effects prophylactic administration pinaverium bromide colonoscopy effects pinaverium bromide alone different time points combined scopolamine butylbromide methods randomized controlled trial performed cohort patients underwent colonoscopy outpatient clinic wuhan union hospital patients randomly assigned following groups group given oral pinaverium bromide three times day one day examination combined intramuscular injection scopolamine butylbromide min colonoscopy group given pinaverium bromide alone day colonoscopy three times day group given pinaverium bromide alone three times day one day colonoscopy group given pinaverium bromide alone three times day two days colonoscopy group given scopolamine butylbromide alone colonoscopy successful rate colonoscopy procedure time degree abdominal pain polyp detection rate recorded compared among groups results successful rate colonoscopy group group significantly higher group successful rate colonoscopy group significantly higher group group moreover time colonoscope reach ileocecal region group markedly shorter compared group group polyp detection rate group significantly higher group group conclusion administration pinaverium bromide alone one day examination beneficial relieve symptoms abdominal pain nonanesthetic colonoscopy addition therapeutic effects improved pinaverium bromide administration combined intramuscular injection scopolamine butylbromide therefore combined use pinaverium bromide scopolamine butylbromide might great application value improve quality nonanesthetic colonoscopy preoperative preparation
background non celiac wheat sensitivity ncws new clinical entity world gluten related diseases nickel frequent cause contact allergy found wheat results systemic nickel allergy syndrome mimics irritable bowel syndrome ibs objective evaluate frequency contact dermatitis due nickel allergy ncws patients diagnosed double blind placebo controlled dbpc challenge identify characteristics ncws patients nickel allergy methods performed prospective study patients females males mean age years diagnosed ncws december november age sex matched subjects functional gastrointestinal symptoms served controls patients reporting contact dermatitis related nickel containing objects underwent nickel patch test clinicaltrials gov registration number nct results six sixty patients ncws suffered contact dermatitis nickel allergy frequency statistically higher observed control group main clinical characteristic ncws patients nickel allergy higher frequency cutaneous symptoms wheat ingestion compared ncws patients suffer nickel allergy conclusions contact dermatitis nickel allergy frequent ncws patients subjects functional gastrointestinal disorders furthermore patients high frequency cutaneous manifestations wheat ingestion nickel allergy evaluated ncws patients cutaneous manifestations wheat ingestion
background nonverbal communication deficits characteristic autism spectrum disorder asd reported later born siblings children asd heightened risk children however little work investigated gesture function language ability varies greatly population aims longitudinal study characterizes gesture children examines differences related diagnostic outcome asd language delay diagnosis age methods procedures coded communicative gesture use children ages years interactions caregiver home outcomes results children asd group produced fewer gestures peers years though large individual differences observed within subgroup ages addition reliance particular types gestures varied age outcome asd language delay children exhibited pattern reduced pointing relative diagnosis peers conclusions implications similarities differences exist communication infants language delay peers reinforcing understanding links verbal nonverbal communication populations risk language delay
background numerous reported studies shown vertebral compression fractures associated impaired function disability however examined association objective measures physical performance functioning methods examined association vertebral compression fractures physical performance measures japanese women aged years lateral spine radiographs obtained radiographic vertebral compression fractures assessed quantitative morphometry defined vertebral heights normal mean measures physical performance included walking speed chair stand time functional reach adjusted means performance based measures according number severity vertebral compression fractures calculated using general linear modeling methods results adjusting age body mass index back pain number painful joints number comorbidities regular physical activities walking speed women two compression fractures significantly slower women without compression fracture compared women without compression fracture chair stand time longer women two compression fractures functional reach shorter significant differences observed walking speed chair stand time functional reach women one compression fracture without compression fracture conclusions multiple vertebral compression fractures affects physical performance community dwelling japanese women poor physical functioning may lead functional dependence accelerated bone loss increased risk falls injuries fractures preventing vertebral compression fracture considered important preserving independence older adults
background numerous statistically derived composite measures recently proposed clinical outcome assessments coas clinical trials early stages alzheimer disease critical path institute coalition major diseases camd advanced proposed statistically derived composite measure regulatory agencies goal qualifying coa pre dementia trials response fda requirement demonstrate proposed coas meaningful patients project aimed identify important cognition related concerns patients informants report early disease determine information maps assessed several statistically derived composite measures methods leveraging qualitative research completed critical path institute patient reported outcome consortium camd utilized summary report included frequency grids reported concerns amnestic mild cognitive impairment patients informants well narrative transcripts focus groups transcripts reviewed analyzed identify cognitive domains patient informant reported concerns mapped onto results compared see well cognitive domains represented various statistically derived composite measures results patient informant reported concerns primarily mapped cognitive domains episodic memory secondarily orientation language depending specified composite varying levels alignment subcomponents cognitive domains conclusion secondary analyses existing qualitative data study examined several statistically derived composite measures found generally capture cognitive domains reflect aspects day day functioning patients informants consider meaningful
background nutrition environmental factor affecting bone health nutrition considered essential achieve maintain optimal bone mass mediterranean diet shown prevent bone disease aim study investigate relationship bone health status adherence methods four hundred eighteen healthy people males females age years recruited outdoor hospital campus salute onlus held piazza del plebiscito naples october october subjects underwent clinical assessment calcaneal quantitative ultrasound qus scanner prevencion con dleta mediterranea predimed questionnaire results globally prevalence osteoporosis osteopenia respectively majority subjects average score score adherence score showed positive correlation predimed score higher scores positively associated higher consumption extra virgin olive oil evoo vegetables fruits legumes fish negatively associated consumption red meat higher scores positively associated highest odds predimed scores higher adherence multiple regression analysis models indicated among single food items investigated high score predicted consumption evoo fish fruit intake predimed score found predictive low score squared index conclusions results demonstrate positive correlation bone health status adherence suggesting high adherence promotes bone health observations reported confirmed specific dietary approach represent modifiable environmental factor osteoporosis prevention
background obesity remains major public health concern mobile apps weight loss management found effective improving health outcomes adults adolescents pursued cost effective scalable intervention combating overweight obesity recent years commercial market weight loss apps expanded rapid pace yet little known regarding evidence based quality tools weight control objective characterize inclusion evidence based strategies health care expert involvement scientific evaluation commercial mobile apps weight loss management methods electronic search conducted july july official app stores four major mobile operating systems three raters independently identified apps stated goal weight loss management well weight loss management apps targeted pediatric users discrepancies regarding selection resolved discussion fourth rater metadata included apps abstracted standard assessment criteria form evidence based strategies health care expert involvement scientific evaluation included apps assessed evidence based strategies included self monitoring goal setting physical activity support healthy eating support weight health assessment personalized feedback motivational strategies social support results total apps included review self monitoring common followed physical activity support weight assessment healthy eating support goal setting motivational strategies social support personalized feedback apps underwent scientific evaluation reported health care expert involvement apps comprehensive assessment criteria majority apps meeting less two criteria conclusions commercial mobile apps weight loss management lack important evidence based features involve health care experts development process undergone rigorous scientific testing calls question validity apps claims regarding effectiveness safety time availability growth adoption tools rapidly increasing collaborative efforts developers researchers clinicians patients needed develop test high quality evidence based mobile apps weight loss management widely disseminated commercial markets
background office workers demonstrate high levels sitting workdays sitting positively associated adverse health risks adults theory driven web based computer tailored intervention influence workplace sitting named start stand developed intervention found effective reducing self reported workplace sitting among flemish employees aim study investigate mechanisms web based computer tailored intervention influenced self reported workplace sitting methods employees participated clustered randomised controlled trial reported socio demographics age gender education work related hours work employment duration health related weight height workplace sitting physical activity psychosocial knowledge attitudes self efficacy social support intention regarding changing sitting behaviours variables baseline month follow product coefficients test mackinnon based multiple linear regression analyses conducted examine mediating role five psychosocial factors knowledge attitudes self efficacy social support intention influence one self regulation skill action planning association intervention self reported workplace sitting time investigated via moderation analyses results intervention positive influence knowledge none psychosocial variables mediate intervention effect self reported workplace sitting action planning found significant moderator decrease self reported workplace sitting occurred group completing action plan conclusions future interventions aimed reducing employees workplace sitting suggested focus self regulatory skills promote action planning using web based computer tailored advice
background one essential aspects provision care cultural issues cultural sensitivity key cultural care aim study explore culturally sensitive care pediatric nursing care iran materials methods study conventional content analysis participants consisted nurses parents selected purposive sampling three pediatric referral centers tabriz tehran iran data collected using semi structured interviews field notes concurrently analyzed using graneheim lundman method data transcribed verbatim words sentences phrases considered meaning units abstracted labeled compared developing categories results culturally sensitive care sick child consisted three themes cultural exposure intercultural communication reconciliation cultural conflict families care cultural exposure nurses informed cultural manifestations strived identify understand patients families cultural diversities respect cultural beliefs nurse used native language intercultural communication combination verbal nonverbal communication methods reach common understanding finally nurse conflict culture child family care took actions making decisions develop compliance care family culture amended parents harmful desires negotiation appropriate care conclusion understanding concept culturally sensitive care help resolving problems cultural exchanges pediatric wards providing cultural facilities interpreters communicate patients family increase satisfaction
background one key challenges biomedical cyber physical system combine cognitive neuroscience integration physical systems assist people disabilities electroencephalography eeg explored non invasive method providing assistive technology using brain electrical signals methods paper presents unique prototype hybrid brain computer interface bci senses combination classification mental task steady state visual evoked potential ssvep eyes closed detection using two eeg channels addition microcontroller based head mounted battery operated wireless eeg sensor combined separate embedded system used enhance portability convenience cost effectiveness experiment conducted five healthy participants five patients tetraplegia results generally results show comparable classification accuracies healthy subjects tetraplegia patients offline artificial neural network classification target group patients tetraplegia hybrid bci system combines three mental tasks three ssvep frequencies eyes closed average classification accuracy average information transfer rate itr system bits min real time testing intentional signal patients tetraplegia average success rate detection speed detection varies
background one frequently investigated hypotheses pathophysiology underlying seasonal affective disorder sad disturbance circadian rhythms since circadian system well non visual effects especially sensitive blue light new light therapy device blue enriched polychromatic light tested efficacy treat sad methods within one winter patients treated one three conditions min full spectrum light min blue enriched light min blue enriched light study lasted days days morning light treatment weekdays first weeks results depressive symptoms sigh sad diminished week period conditions significant differences conditions percentage responders high differing standard min blue enriched min blue enriched respectively conclusion lack superiority high intensity blue enriched light standard bright light treatment clearly support rule possibility important role circadian system blue sensitive non visual image forming system general pathophysiology sad lack difference conditions may also result saturated response high light intensities used recent data indeed suggest low intensity blue enriched light may effective standard bright light treatment possibility improving light therapy sad patients applying light shorter duration lower light intensities highly relevant optimizing treatment help clarify role circadian system non image forming photoreceptors sad pathophysiology
background biomarkers available assessing disease activity systemic lupus erythematosus sle mean platelet volume mpv recently studied inflammatory biomarker currently unclear whether mpv may also play role biomarker disease activity adult patients sle objective investigated association mpv disease activity adult patients sle methods retrospective study compared two groups adult patients divided according disease activity per group subjects age gender matched results mpv significantly decreased respect inactive patients cutoff level mpv sensitivity specificity detection disease activity modest positive correlation found mpv albumin turn inversely associated disease activity conclusions summary mpv decreased adult patients active lupus disease positively correlated albumin another biomarker disease activity prospective studies needed evaluate prognostic value biomarker elsevier editora ltda
background osteosarcoma typically develops puberty tumors arising sites rapid bone growth suggesting role growth regulating pathways tumor etiology birthweight one measure perinatal growth investigated osteosarcoma risk factor whether birthweight affects clinical features osteosarcoma remains unexplored method six hundred seventy patients osteosarcoma aged years identified california cancer registry analyzed birth certificate data california department public health vital statistics unit patients controls matched sex birth year race ethnicity examined impact birthweight risk timing clinical presentation pediatric osteosarcoma including tumor location size extension differentiation presence metastasis age onset regression models adjusted race sex gestational age socioeconomic status tumor site results higher birthweight associated advanced tumor stage trend toward greater tumor extension surrounding tissues occurrence tumors sites long bones arms legs higher birthweight also associated increased likelihood metastases present diagnosis increase birthweight associated fold increase odds metastatic disease confidence interval conclusions association higher birthweight aggressive osteosarcoma frequently occurring sites long bones suggests growth pathways active gestation may play important role future osteosarcoma progression especially anatomic sites diminished rates osteoblastic proliferation
background otilonium bromide spasmolytic agent acting type calcium channel antagonist intestinal colonic smooth muscle cells smcs analyzed three independent clinical trials homogeneous design patients irritable bowel syndrome ibs weeks receiving placebo patients randomized receive daily placebo weeks aimed perform pooled analysis data homogeneous clinical trials evaluate efficacy treatment symptoms global response patients methods total patients ibs women mean age years mixed type included treated placebo efficacy results three studies weeks pooled intention treat itt strategy analyzed logistic regression model described forest plots results despite placebo effect efficacy variables significant therapeutic effect observed weeks reference intensity frequency abdominal pain rate responders evaluated patients week week severity bloating rate responders evaluated physicians week week significant effect observed stool frequency consistency conclusions effective placebo ibs treatment therapeutic benefits significant weeks maximal weeks treatment
background nurse delivered comprehensive self management csm program cognitive behavioral therapy intervention effective reducing gastrointestinal psychological distress symptoms patients irritable bowel syndrome ibs findings non ibs studies indicate catechol methyltransferase comt valmet polymorphism may moderate efficacy cognitive behavioral therapy unknown whether comt polymorphism associated symptom improvements patients ibs objective tested whether comt valmet polymorphism influences efficacy month csm intervention methods analyzed data two published randomized controlled trials csm combined european american sample included women men ibs csm usual care primary outcomes daily reports abdominal pain depression anxiety feeling stressed measured months randomization secondary outcomes additional daily symptoms retrospective psychological distress ibs quality life cognitive beliefs ibs interaction comt valmet polymorphism treatment group csm generalized estimating equation model tested main objective results months participants least one val allele benefited csm met met genotype anxiety feeling stressed abdominal pain depression moderating effect genotype weaker months discussion persons least one val allele may benefit csm homozygous met allele future studies larger racially diverse samples needed confirm findings
background overactive bladder oab relatively common disease linked variety comorbidities reductions quality life increased healthcare costs antimuscarinic agents standard care among pharmacologic treatments oab drugs linked high levels anticholinergic burden especially elderly objective demonstrate efficient data analysis used identify gaps care result improvement strategies oab within integrated healthcare delivery system setting methods developed oab treatment patterns analyzer clinical outcomes software analysis program identify gaps care high anticholinergic burden potential quality improvement initiatives deidentified pharmacy medical claims data integrated delivery network imported oab treatment patterns analyzer patients diagnosis oab continuously enrolled network january december identified imported analyzer analyzer used national drug code international classification diseases ninth edition clinical modification current procedural terminology codes measure treatment patterns comorbid conditions anticholinergic burden concomitant use anti cholinesterases costs healthcare resource utilization results members integrated delivery network population patients met study eligibility criteria patients taking medications oab nonadherent discontinued treatment within year among patients integrated healthcare delivery system using medications oab patients concomitantly taking anticholinesterase drugs antimuscarinic agent per month plan paid cost per member patients oab within population rates cause office visits emergency department visits hospitalizations respectively rate clinically relevant anticholinergic burden higher rates among patients dementia also receiving branded generic antimuscarinic drug conclusion patients using medications treatment oab rates medication persistence adherence poor antimuscarinic medications may place certain patient populations risk increased anticholinergic burden data included analyzer used implement member specific strategies prevent poor outcomes reduce associated healthcare costs utilization
background overt subclinical hypothyroidism common finding adult populations affected non alcoholic fatty liver disease nafld currently sparse data available association thyroid dysfunction nafld obese children adolescents objective study aims investigate association thyroid function test values nafld metabolic risk factors population obese children adolescents methods total overweight obese children adolescents girls aged years analysed subjects underwent ultrasound examination liver thyroid function evaluated laboratory determination thyroid stimulating hormone tsh total triiodothyronine total thyroxine levels included subjects either euthyroid subclinical hypothyroidism tsh uml normal thyroxine metabolic profiling included determination lipid status insulin liver function tests anthropometric parameters body mass index waist hip circumference documented results prevalence hepatic steatosis subjects nafld significantly higher tsh levels without dividing tsh values quartiles univariate multivariate analyses adjusted age body mass index standard deviation scores stage puberty showed significant association hepatic steatosis conclusion taking possible variables consideration results show significant association hepatic steatosis tsh levels obese children adolescents mild thyroid dysfunction may therefore role determining unfavourable metabolic profile obese children adolescents
background oxidative stress one important factors involved pathogenesis idiopathic pulmonary fibrosis ipf equilibrium nuclear factor erythroid related factor nrf btb broad complex tramtrack bric brac cnc cap collar protein homology bach determines expression level antioxidant factors regulating function oxidation antioxidation capacity pirfenidone pfd one two currently ipf therapy approved drugs pfd regulates intracellular antioxidants inhibits secretion inflammatory cytokines collagen synthesis however mechanisms antioxidant effects remain elusive methods effects pfd treatment studied mouse lung fibroblasts mlf following induction transforminggrowth factor beta tgf beta mice following bleomycin induced lung fibrosis mrna protein levels oxidative stress related factors nrf bach downstream antioxidant factors heme oxygenase glutathione peroxidase gpx determined pcr western blot fibrosis related cytokines interleukin myofibroblast markers type collagen alpha cola levels supernate mlf serum bronchoalveolar lavage fluid balf well malondialdehyde mda serum balf detected elisa reactive oxygen species ros generation measured dichlorofluorescin diacetate dcfh assay lung pathological morphological alterations mice observed masson assess antioxidant mechanism therapeutic effects pulmonary fibrosis induced bleomycin results pfd inhibited bach mrna protein expressions mouse lung fibroblasts induced tgf beta lung tissues pulmonary fibrosis induced bleomycin furthermore improved nrf gpx mrna protein expressions pfd treatment colaand levels supernate mlf serum balf well ros lung tissues mda serum balf mouse pulmonary fibrosis significantly decreased infiltration lung inflammatory cells fibrosis degree alleviated conclusions theraputic effects pfd ipf involved nrf bach equilibrium regulated capacity oxidative stress study provided new insights antioxidant mechanism pfd
background patients advanced cancer dependent children important population life limiting illness high levels psychological distress studies addressed experience parent advanced cancer potential palliative needs aim describe experience living advanced cancer parent including illness experience parental concerns treatment decision making explore whether experiences differ functional status design conducted cross sectional qualitative study using depth semi structured interviews data analyzed using thematic content analysis setting participants total participants metastatic cancer least one child age years recruited comprehensive cancer center participants rated high functional status eastern cooperative oncology group ecog performance status scale low functional status ecog results identified four themes regarding experience parent advanced cancer parental concerns impact illness death children missing losses parental role responsibilities maintaining parental responsibilities despite life limiting illness parental identity influencing decision making treatment parental functional status influenced physical responsibilities also intensified parenting psychological concerns conclusion parents metastatic cancer may unique palliative care needs experience parenting concerns managing psychological physical demands advanced cancer
background patients angioedema experience unpredictable attacks tissue swelling bradykinin implicated several distinct mutations factor xii fxii associated hereditary angioedema hae inthe presence normal esterase inhibitor activity fxii hae underlying disease mechanisms unclear complicates diagnosis treatment objective sought identify natural trigger fxii activation causes uncontrolled bradykinin production patients fxii hae methods generated recombinant variants fxii representing health disease studied behavior functional studies investigated bradykinin forming pathways blood plasma newly developed nanobody based analytic methods results report fxii hae mutations collectively introduce new sites sensitive enzymatic cleavage plasmin fxii mutants rapidly activate cleavage plasmin escape inhibition esterase inhibitor elicit excessive bradykinin formation furthermore findings indicate plasmin modulates disease activity patients fxii hae finally show soluble lysine analogs attenuate mechanism explaining therapeutic value patients hae conclusion findings indicate new pathway bradykinin formation patients hae fxii cleaved activated plasmin lead identification new markers diagnosis targets treatment
background patients crohn disease higher failure rate ileal pouch surgery compared counterparts ulcerative colitis objective hypothesized risk continent ileostomy failure stratified based timing crohn disease diagnosis aimed assess long term outcomes design retrospective cohort study settings investigation took place high volume specialized colorectal surgery department patients patients crohn disease underwent continent ileostomy surgery evaluated main outcome measures functional outcomes postoperative complications requirement revision surgery continent ileostomy failure analyzed results patients male patients median age years time continent ileostomy creation crohn disease diagnosis continent ileostomy intentional made delayed fashion median years continent ileostomy patients median follow years range index continent ileostomy creation major minor revisions performed patients complications fistula pouchitis valve slippage hernia afferent limb stricture difficult intubation incontinence bowel obstruction valve stricture leakage bleeding valve prolapse median cleveland global quality life score continent ileostomy failure occurred patients based kaplan meier estimates continent ileostomy survival years continent ileostomy failure similar regardless timing diagnosis crohn disease limitations study limited retrospective nonrandomized nature conclusions outcomes continent ileostomy patients crohn disease poor regardless timing diagnosis careful consideration given surgeon patient undertaking procedure patients crohn disease
background patients major depressive disorder mdd present heterogeneous clinical symptoms childhood abuse associated deepening psychopathology aim study identify structural brain abnormalities mdd assess differences gray matter density gmd associated childhood abuse mdd methods differences regional gmd mdd patients healthy controls assessed using magnetic resonance imaging optimized voxel based morphometry within mdd group comparisons performed focusing experience maltreatment childhood mdd child abuse mdd without child abuse results compared healthy controls mdd patient group showed decreased gmd bilateral orbitofrontal cortices right superior frontal gyrus right posterior cingulate gyrus bilateral middle occipital gyri left cuneus addition patient group showed increased gmd bilateral postcentral gyri parieto occipital cortices putamina thalami hippocampi left cerebellar declive tuber vermis within mdd patient group subgroup abuse showed tendency decreased gmd right orbitofrontal cortex showed increased gmd left postcentral gyrus compared subgroup without abuse conclusions findings suggest complicated dysfunction networks cortical subcortical circuits mdd addition increased gmd postcentral gyrus possible reduction gmd orbitofrontal cortex mdd patients abuse subgroup may associated abnormalities body perception emotional dysregulation
background pendred syndrome pds mim autosomal recessive disorder characterized congenital sensorineural hearing loss goiter study describing possible pds causal mutations malaysian family daughters diagnosed bilateral hearing loss hypothyroidism methods results whole exome sequencing performed sisters pds unaffected parents results showed sisters inherited monoallelic mutations known pds genes slca enst serleu gjb enst thrasn father well another deafness related gene scarb enst thrmet mother postulated three heterozygous mutations combination may causative deafness warrants investigation furthermore also identified compound heterozygosity involving duox gene enst lys arggln sisters inherited parents may correlated early onset goiter candidate mutations predicted deleterious silico tools conclusions summary proposed pds family could polygenic disorder possibly arises combination heterozygous mutations slca gjb scarb associated deafness well compound heterozygous duox mutations associated thyroid dysfunction
background people treatment substance use disorder commonly comorbid personality disorders including antisocial personality disorder little known treatments specifically address comorbid antisocial personality disorder methods self rated help received antisocial personality disorder assessed follow ups months post randomization randomized trial psychoeducation people comorbid substance use antisocial personality disorder results randomization psychoeducation associated increased perceived help antisocial personality disorder perceived help antisocial personality disorder turn associated days abstinent higher treatment satisfaction month follow reduced risk dropping treatment month follow perceived help mediated effects random assignment days abstinent month follow conclusions brief psychoeducation antisocial personality disorder increased patients self rated help antisocial personality disorder substance abuse treatment reporting received help antisocial personality disorder turn associated better short term outcomes days abstinent dropout treatment treatment satisfaction
background phanerochaete sordida species wood rotting fungus degrade lignin cellulose hemicellulose contained wood hard biodegrade organic substances however date reports demonstrating sordida infect humans case presentation year old japanese man presented mass increasing size left thigh suffering rheumatoid arthritis years chronic obstructive pulmonary disease years treated day prednisolone week methotrexate mass resection performed two months later diagnosed malignant fibrous histiocytosis however computed tomography examination tumor recurrence surgery showed newly emergent pulmonary nodule therefore decided resect nodule thoracoscopic procedure histopathological examination excised specimen showed lesion granuloma necrotic tissue clumping aspergillus like hyphae therefore nodule diagnosed fungal infection tissue specimens cultured microbiologically however fungal growth observed consequently performed genetic analysis using broad range polymerase chain reaction rrna sequence demonstrated homology sordida using ncbi blast program genbank dna databases conclusions using broad range polymerase chain reaction identified sordida causative agent pulmonary nodule findings indicate sordida may additional opportunistic causative organism pulmonary infection immunocompromised patients
background population structure inference using software structure become integral part population genetic studies covering broad spectrum taxa including humans ever expanding size genetic data sets poses computational challenges analysis although least one tool currently implements parallel computing reduce computational overload analysis fully automate use replicate structure analysis runs required downstream inference optimal pressing need tool deploy population structure analysis high performance computing clusters results present updated version popular python program strauto streamline population structure analysis using parallel computing strauto implements pipeline combines structure analysis evanno delta analysis visualization results using structure harvester using benchmarking tests demonstrate strauto significantly reduces computational time needed perform iterative structure analysis distributing runs two processors conclusion strauto first tool integrate structure analysis post processing using pipeline approach addition implementing parallel computation set ideal deployment computing clusters strauto distributed gnu gpl general public license available download http strauto popgen org
background postoperative major bleeding relatively common complication patients undergoing corrective surgery tetralogy fallot tof life threatening blood losses lead aggressive transfusions reoperation little known risk factors associated bleeding tendency tof patients study aimed establish predictive models postoperative blood loss mortality tof patients methods conducted retrospective observational study involving patients tof posted corrective cardiac surgery single hospital hospital records including sociodemographic pre intra operative characteristics extracted postoperative blood loss within day mortality primary secondary outcomes respectively multivariate linear logistic regression models used identify determinants outcomes results total patients included study median age year interquartile range male female ratio mean postoperative blood loss within multivariate linear regression preoperative hematocrit beta duration intraoperative oxygenator cpb beta significantly correlated postoperative blood loss within adjusting sociodemographic intra post operative characteristics preoperative hematocrit odds ratio confidence interval postoperative red blood cell transfusions showed statistically significant association day mortality area receiver operating characteristic curve multivariable model conclusions preoperative levels erythrocytosis appear predict postoperative blood loss short term mortality tof patients undergoing corrective surgery
background postpartum depression causes harm mothers infants purpose study find several potential risk factors identify intrinsic interrelationships factors postpartum depression constructing path model results study may help control increasing incidence maternal postpartum depression methods study based sample mothers cross sectional study set weeks mother childbirth conducted three streets kaifu district changsha hunan province january december questionnaires distributed subjects responded questions concerning factors related pregnancy delivery infants within weeks childbirth edinburgh postnatal depression scale epds used measure postpartum depression chi square test used detect significant differences non postpartum depression group postpartum depression group path model constructed explore interrelationships variables verify relationships variables postpartum depression results proportion maternal postpartum depression univariate analysis showed significant differences non postpartum depression group postpartum depression group values part maternal age parity frequent exposure mobile phone pregnancy gestational hypertensive disorders fetus number premature delivery birth weight initiation breastfeeding mode feeding infant illness within weeks delivery infant weight weeks path analysis results showed final model could fitted well sample data cmin nfi rfi ifi tli cfi rmsea frequent exposure mobile phone pregnancy maternal age gestational hypertensive disorders direct indirect effects postpartum depression mode feeding infant weight weeks total effect postpartum depression direct impact postpartum depression fetus number premature delivery initiation breastfeeding birth weight indirect influence postpartum depression conclusion findings study suggest constructing path analysis model could identify potential factors explore potential interrelations factors postpartum depression effective way prevent maternal postpartum depression taking appropriate intervention measures carrying health education pregnant women
background postresection intestinal adaptation augmented self renewal process might increase risk malignant transformation intestine furthermore patients short bowel syndrome sbs characteristics might increase risk aim determine incidence new intestinal malignancy sbs patients methods reviewed records adult sbs patients identified men women ranging age years follow time diagnosis sbs ranged months total patients followed years results cause sbs postoperative patients malignancy radiation mesenteric vascular disease crohn disease twenty eight patients received growth stimulatory medications fifteen percent patients prior total colectomy twenty eight patients underwent intestinal transplantation patients previous abdominal malignancy including colorectal cancer patients thirty six received radiation therapy recurrent colon cancer found patients one stoma lung metastases new colon cancer found patient year old woman long standing crohn disease conclusion incidence colon cancer heterogenous group patients sbs similar normal population suggests risk developing new colon cancer patients sbs increased
background posttransplantation bone disease significant problem well evidenced therapeutic options proton pump inhibitors ppis associated hip fracture general population widely prescribed kidney transplant recipients study design case control study setting participants renal data system identified diagnoses procedures kidney transplant recipients first hip fracture cases matched hip fracture index date controls age sex race transplantation year predictor ppi use outcomes first hip fracture results year prior index date ppi prescribed cases controls additionally cases controls ppi prescribed year preceding index date higher ppi users unadjusted ors hip fracture associated higher ppi use respectively adjusted baseline demographic clinical pharmacologic covariables higher ppi use remained associated hip fracture ors respectively limitations potential residual confounding either incorrectly ascertained unavailable confounders cohort limited medicare beneficiaries receiving low income subsidy conclusions summary ppi use associated hip fracture risk kidney transplant population national kidney foundation inc
background post traumatic osteoarthritis ptoa responsible majority cases ankle arthritis acute end stage intra articular inflammation previously described state joint fracture healing end stage ptoa remains undefined study characterized synovial fluid composition ankles bone healing intra articular fracture identify factors may contribute development ptoa methods original patients whose characterized acutely following intra articular ankle fractures returned planned hardware syndesmotic screw removal bone healing approximately months consented second bilateral collection concentrations cytokines matrix metalloproteinases mmps markers cartilage catabolism ctxii glycosaminoglycan hemarthrosis biliverdin bilirubin compared previously fractured contralateral uninjured ankles patient analysis also performed determine effect number fracture lines involvement soft tissue composition results interleukin mmp mmp mmp significantly elevated healed ankles compared matched contralateral uninjured ankles approximately months fracture differences markers cartilage catabolism hemarthrosis affected number fracture lines differences detected analytes respect involvment soft tissue conclusions sustained intra articular inflammation even complete bone healing suggested elevations pro inflammatory cytokines addition elevated concentrations mmps also noted consistent persistent inflammatory environment study suggests new evidence persistent intra articular inflammation intra articular ankle fracture healing suggests potential mediators ptoa development clinical relevance work may relevant clinical diagnosis treatment post traumatic osteoarthritis
background posttraumatic stress disorder ptsd complex ptsd borderline personality disorder bpd share etiological risk factors overlapping set associated symptoms since icd proposal trauma related disorders relationship disorders clarified novel approach psychopathology network analysis allows fora detailed analysis comorbidity symptom level methods symptoms assessed adult survivors childhood abuse using newly developed icd trauma questionnaire scid psychopathological network analyzed using network approach results ptsd complex ptsd symptoms strongly connected within disorders lesser degree disorders symptoms bpd weakly connected others experiencing dissociation central symptoms conclusions mental disorders discrete entities clear boundaries unlikely found psychopathological network revealed central symptoms might important targets specific first interventions elsevier ltd rights reserved
background pregnancy strongly influences thyroid gland function thyroid guidelines recommend increase preconceptional levothyroxine dose women hypothyroidism pregnancy diagnosed case year old week pregnant woman hypothyroidism presents week history palpitations sweating nervousness fatigue physical examination shows tachycardia bpm distal tremors diffuse goiter biochemical confirmation hyperthyroidism levothyroxine dose reduced finally interrupted propylthiouracil started maintained delivery healthy baby week two weeks postpartum hyperthyroidism worsens propylthiouracil replaced methimazole eighteen months delivery mci iodine given two months later hypothyroidism developed levothyroxine initiated conclusion although conversion hashimoto hypothyroidism graves disease exceptional pregnancy pregnant women autoimmune hypothyroidism ideally tsh concentrations measured empirically increasing levothyroxine dose
background previous estimates economic burden crohn disease varied widely billion per year adjusted however estimates reflect recent changes pharmaceutical treatment options guidelines objective goal study update cost estimates crohn disease based representative sample population recent years medical expenditure panel survey meps secondary aim described expenditure trends respondents without crohn disease pre post fda approvals new biologics american college gastroenterology crohn disease treatment guidelines methods average annual expenditures total prescription inpatient outpatient evaluated using pooled cross sectional design respondent data recent years meps analyzed two part generalized linear models power link used estimate average annual expenditures per patient adjusted multiple covariates confidence intervals estimated using bootstrap methods difference differences estimations performed compare changes health care expenditures pre post fda approvals new biologics american college gastroenterology crohn disease treatment guidelines results annual aggregate economic burden billion respondents higher total prescription inpatient outpatient expenditures compared respondents without difference differences estimation respondents significantly higher total prescription expenditures compared respondents without although inpatient outpatient expenditures higher respondents statistically significant conclusions respondents diagnosis higher expenditures compared respondents without diagnosis study captured recent availability new treatment options changes treatment guidelines providing updated estimates economic burden inthe however research unable study causes increased health care expenditures respondents future investigations need determine causal factors increased expenditures elsevier inc rights reserved
background previous studies noticed high incidence suboptimal vitamin vtd status bone loss short bowel syndrome sbs parenteral nutrition dependence however limited data focused adult sbs without dependence therefore objective investigate incidence risk factors suboptimal vtd status bone loss adult sbs even weaning materials methods performed prospective study adult patients sbs serum hydroxyvitamin ohd measured radioimmunoassay bone mineral density bmd measured using dual energy ray absorptiometry dexa medical records various laboratory parameters collected participants results suboptimal vtd status identified individuals including vtd insufficiency vtd deficiency residual small bowel length duration sbs significantly correlated suboptimal vtd levels overall patients presented normal bmd osteopenia osteoporosis noted individuals respectively low ohd concentration associated decreased bmd demographic characteristics clinical examinations associated suboptimal vtd levels bone loss conclusion suboptimal vtd status bone loss common adult sbs even weaning despite routine oral vtd supplementation patients achieve satisfactory status emphasizes critical importance routine surveillance ohd bmd well consideration alternative methods supplementation weaning
background prices anti cancer drugs skyrocking aimed assess clinical benefit new drugs treating advanced solid tumors time approval food drug administration fda search relation price clinical benefit drugs materials methods included new molecular entities new biologics treating advanced solid cancer approved fda clinical benefit drugs graded based fda medical review pivotal clinical trials using updated american society clinical oncology value framework asco european society medical oncology magnitude clinical benefit scale esmo mcbs characteristics drugs approvals obtained publicly available fda documents price evaluated according medicare veterans health administration united kingdom market systems results fda approved new drugs advanced solid cancer could evaluate value drugs esmo mcbs five drugs grade one lowest nine grade two grade three grade four two grade five highest thus drugs showed meaningful clinical benefit scale levels asco range median drug value interquartile range found relationship clinical benefit drug price characteristic drugs approval significantly associated clinical benefit conclusion many recently fda approved new cancer drugs high clinical benefit measured current scales found relation price drugs benefit society patients
background prior research repeatedly shown alcohol dependence associated large range impairments psychological processes could lead interpersonal deficits specifically suggested interpersonal difficulties underpinned reduced recognition sharing others emotional states however pattern deficits remains clarified study thus aimed investigate whether alcohol dependence associated impaired abilities decoding contextual complex emotions altered sharing others emotions methods forty one alcohol dependent individuals adi matched healthy individuals completed multifaceted empathy test instructed identify complex emotional states expressed individuals contextual scenes state extent shared results compared healthy individuals adi impaired identifying negative cohen positive cohen emotional states conversely presented preserved abilities sharing others emotional states conclusions study shows alcohol dependence characterized impaired ability decode complex emotional states positive negative despite presence complementary contextual cues preserved emotion sharing therefore results extend earlier data describing impaired ability decode noncontextualized emotions toward contextualized ecologically valid emotional states also indicate essential emotional competences emotion sharing preserved alcohol dependence thereby offering potential therapeutic levers
background psychiatric illness common among young adults studies examining views care receive paradigm shift towards person centred care therefore need patients perspectives development clinical guidelines aim aim study examine views provided psychiatric care group young adult psychiatric patients method study part larger study patients ages years old diagnosed bipolar disorder borderline personality disorder attention deficit hyperactivity disorder interviewed participants answered open ended questions concerning views provided psychiatric care six different areas result results categorized six themes wish better diagnostic assessments dissatisfaction treatment inadequate information lack professional attitude feeling abandoned satisfaction care conclusion young psychiatric patients expressed need improvement services implemented could make psychiatric care person centred
background psychosocial distress among patients limited life expectancy influences treatment decisions treatment adherence physical health veterans may elevated risk psychosocial distress end life understanding mental healthcare needs may help identify hospitalized patients psychiatric services targeted objective examine mental illness prevalence mental health treatment rates among national sample hospitalized veterans serious physical illnesses design subjects measurements retrospective study veterans hospitalized veterans health administration acute care facility fiscal year diagnoses advanced cancer congestive heart failure chronic obstructive pulmonary disease advanced hiv aids prevalent incident mental illness diagnoses hospitalization rates psychotherapy psychotropic use among patients incident depression anxiety measured results least one quarter patients sample mental illness substance use disorder common diagnoses hospitalization depression followed alcohol abuse dependence post traumatic stress disorder patients incident past year depression incident past year anxiety nearly two thirds received least psychotherapy guideline concordant medication within days diagnosis patients incident depression incident anxiety time hospitalization fewer half received mental healthcare discharge conclusions many veterans hospitalized serious physical illnesses comorbid mental illnesses may benefit depression anxiety treatment
background segment prolongation high risk factor fatal arrhythmias several studies indicated possible relation low testosterone levels interval prolongation objectives compare interval length elderly patients prostate carcinoma anti testosterone treatment methods screened electrocardiograms ecgs prostate cancer patients divided two groups patients anti testosterone drug treatment patients interval length measured according accepted methods results mean qtc leads entire group sec close upper limit mean qtc actually longer control group qtc difference groups adjustment possible confounders prolonged qtc lead ecg treated non treated lead interval treated non treated differ significantly groups analysis qtc lead ecg indicated significant effects anti testosterone drug treatment use furosemide associated prolongation conclusions results preliminary study support initial concern alarmingly prolonged interval anti testosterone treated group however prospectively designed studies needed meanwhile call fora close follow interval length patients receiving anti testosterone treatment
background radiogenetic therapy novel approach treatment cancer employs genetic modification alter sensitivity tumor cells effect applied radiation aim select potent radiation inducible promoter context brain tumors investigate carg radio responsive motifs elements promoter nucleotide sequences correlate response radiation methods select initial candidates promoter inducible elements levels mrna expression six different promoters assessed using quantitative rtpcr cells radiation exposure recombinant reporter genes driven five different promoters cmv vegf flt survivin constructed glioma cell lines infected different multiplicity infection promoter cmv cells exposed range radiation single fraction fluorescent microscopy luc assay gal staining used detect level expression related genes different glioma cell lines normal astrocytes infected survivin exposed radiation promoters analyzed presence carg radio responsive motifs ccaat box consensus using ncbi blast bioinformatics software results radiotherapy increases expression gene expression fold different promoters survivin radiation rna analysis done shown increase copy number tenfold survivin importantly cells treated luc driven survivin promoter showed fivefold increase expression radiation comparison non irradiated cells presence absence carg motifs correlate promoter response radiation survivin best response radiation lowest number ccaat box conclusion survivin selective potent radiation inducible promoter glioblastoma viral gene therapy response radiation could independent carg motifs
background radiotherapy head neck cancers hnc causes alteration oral mucosal barrier predisposing colonization infection infections often result pain burning sensation thus contributing major morbidity objective identify fungi isolated patients undergoing radiotherapy hnc determine antifungal susceptibility week colonization find association oral fungal infection severity oral mucositis materials methods study done patients hnc treated concurrent chemoradiotherapy three samples throat urine blood collected fungal culture sensitivity samples collected start radiotherapy radiotherapy week post radiotherapy week results patients available analysis fungal infection found patients non albicans candida isolated candida albicans cases isolates sensitive fluconazole maximum isolation yeast week radiotherapy grade grade oral mucositis found patients positive fungal infection conclusion spectrum fungal species throat swab non albicans candida candida albicans observed patients respectively higher rate fungal colonization infection found patients grade oral mucositis prophylactic fluconazole hnc patients concurrent chemoradiotherapy potential reduce emerging invasive fungal infection associated morbidity national cancer institute cairo university production hosting elsevier open access article license
background ratios digit lengths studied intensively markers prenatal sex hormone levels aim study sexual dimorphism ratios metacarpals received less attention methods studied six metacarpal ratios deceased human fetuses ages weeks results conclusion found indication sexual dimorphism early stage development elsevier ireland ltd rights reserved
background reactome aims provide bioinformatics tools visualisation interpretation analysis pathway knowledge support basic research genome analysis modelling systems biology education pathway analysis methods broad range applications physiological biomedical research one main problems analysis methods performance point view constantly increasing size data samples results present new high performance memory implementation well established overrepresentation analysis method achieve target representation analysis method divided four different steps specific data structures used improve performance minimise memory footprint first step finding whether identifier user sample corresponds entity reactome addressed using radix tree lookup table second step modelling proteins chemicals orthologous species composition complexes sets addressed graph third fourth steps aggregate results calculate statistics solved double linked tree conclusion use highly optimised memory data structures algorithms reactome achieved stable high performance pathway analysis service enabling analysis genome wide datasets within seconds allowing interactive exploration analysis high throughput data proposed pathway analysis approach available reactome production web site either via analysisservice programmatic access user submission interface integrated pathwaybrowser reactome open data open source project source code including one described available analysistools repository reactome github
background recent evidence demonstrates benefits integrated agriculture nutrition programs children health nutrition outcomes programs may also improve mothers nutrition empowerment outcomes however evidence rigorous evaluations scarce objective examined impacts helen keller international enhanced homestead food production hfp program burkina faso secondary impact measures mothers nutrition empowerment methods used cluster randomized controlled trial whereby villages mothers young children randomly assigned groups control hfp behavior change communication bcc strategy implemented older women leaders hfp bcc implemented health committee members data treatment groups pooled analysis differences found groups key mothers outcomes used difference differences estimates assess impacts mothers dietary intake diversity body mass index bmi prevalence underweight bmi empowerment results hfp program significantly increased mothers intake fruit percentage points marginally increased intake meat poultry percentage points dietary diversity points prevalence underweight significantly reduced among mothers treatment compared control villages percentage points although changes bmi differ mothers treatment control villages marginally significant interaction baseline underweight change bmi interaction indicating underweight mothers greater increase bmi mothers underweight hfp program also positively affected mothers overall empowerment score points possible points components empowerment meeting women points possible points purchasing decisions points possible points health care decisions points possible points conclusions helen keller international hfp program burkina faso substantially improved mothers nutrition empowerment outcomes positive impacts benefit mothers may also improve ability care children
background recommendations care first week newborn life include thermal care practices drying wrapping skin skin contact immediate breastfeeding delayed bathing paper examines beliefs practices related neonatal thermal care three african countries methods data collected way site included narrative interviews recent mothers eight observations neonatal bathing depth interviews mothers grandmothers eight health workers birth attendants site results found similarities across sites relation understanding importance warmth lack opportunities skin skin care beliefs importance several baths per day beliefs vernix caseosa related poor maternal behaviours variation sites beliefs practices around wrapping drying delivery timing first bath recent behavior change sites near universal early bathing babies nigerian sites linked deep rooted belief body odour asked keeping baby warm respondents across sites rarely mentioned recommended thermal care practices suggesting perceived salient conclusion effort needed promote appropriate thermal care practices facilities home programmers aware changing deep rooted practices early bathing nigeria may take time utilize current beliefs importance neonatal warmth facilitate behaviour change
background reduction risk injury crucial football clubs previous injuries important risk factor football injuries due important myofascial restrictions since effectiveness procedures observed physium may useful device could used prevent risk injury objective evaluate safety effectiveness physium reduction risk injuries injury rate one season indoor football matches players present risk injuries material methods indoor football players years chronic injury included study confirmed clinically risk injury assessed physiotherapist using biomechanical test salo darder players myofascial restrictions match received sessions minutes treatment physium week results physium reduce risk injuries points score maximum professional players players declared fit play next game therapy discussion physium device designed improve muscle recovery prevent sports injuries present research innovative field recovery injury players physium appears safe reduces risk injuries football players doubt conclusions reached help improve health many players athletes future comparative studies would prove physium role reducing risk injury
background registries drug deaths may include different persons provide different characteristics deceased aim study establish whether database drug induced deaths cause death registry cdr using european monitoring centre drugs drug addiction emcdda definition police registry drug deaths included persons provided characteristics deceased thus yielded information establishing targeted prevention measures methods notifications drawn cdr police registry drug deaths unique norwegian personal identification number used match registrations results two sources drug deaths yielded registrations encompassing individuals included registries large proportion deceased listed police registry group older mean age years years dependence suicide listed often cause death heroin listed less often type drug causing death included registries particular among women included police registry cause death identified much greater frequency pharmaceuticals morphine codeine conclusion large discrepancies size overlap characteristics deceased included two sources drug death imply prevention measures based two sources differ elsevier rights reserved
background remission arguably ultimate therapeutic goal rheumatoid arthritis applying modern strategies clinical remission achieved substantial number patients early era even patients number scope erosions increase therefore investigated value mri detection radiological progression patients das improvement clinical remission german remission plus cohort methods data sets patients according acr eular criteria remission plus study cohort fulfilled following criteria retrospectively analysed availability two consecutive mri scans low field mri follow interval year clinically dominant hand wrist presence das crp scores time points used assess disease activity results seventy one investigated patients presented numerical improvement das crp months das crp average empty set das month empty set also improved ramris score demonstrated increase despite das improvement showed equal values patients improved das reached eular remission patients increase ramris erosion subscore months considering eular response criteria non response moderate response good response increase erosions found non responders moderate responders good responders months compared baseline conclusion patients study demonstrated progressive erosive disease detected mri despite das improvement eular remission future studies needed determine prognostic clinical impact disease progression mri despite clinical remission investigate das remission may insufficient therapeutic goal accompanied mri remission criteria
background research found injury rates football higher competition practice however little research association injury rates type football practices specific rates compare competitions purpose study utilized data national collegiate athletic association injury surveillance system ncaa iss describe men collegiate football practice injuries academic years event types competitions scrimmages regular practices walkthroughs study design descriptive epidemiological study methods football data academic years analyzed annually average men football programs provided data universities sponsoring football injury rates per athlete exposures aes injury rate ratios rrs cis injury proportions reported results ncaa iss captured football injuries injuries reported regular practices followed competitions scrimmages walkthroughs aes reported regular practices followed walkthroughs competitions scrimmages highest injury rate found competitions aes followed scrimmages aes regular practices aes walkthroughs aes rates significantly different one another distributions injury location diagnoses similar across event types injuries occurring lower extremity consisting sprains strains however injury mechanisms varied proportion injuries due player contact greatest scrimmages followed regular practices walkthroughs contrast proportion injuries due noncontact overuse greatest walkthroughs followed regular practices scrimmages conclusion injury rates highest competitions varied type practice event higher practice injury rates reported scrimmage addition greater proportions injuries reported regular practices greater proportions exposures reported regular practices walkthroughs efforts minimize injury types practice events essential mitigating injury incidence related contact noncontact
background research association antisocial personality disorder aspd comorbid mental disorders sexually transmitted infection sti hiv risk among inmates scant despite high prevalence psychopathology sti hiv population methods used baseline data project disrupt cohort study conducted among incarcerated african american men measure associations aspd sti hiv risk also conducted latent class analyses lcas identify subgroups defined aspd comorbid stress depression borderline personality disorder symptoms measured associations latent class membership sti hiv risk results approximately aspd reported depression controlling sociodemographics stress depression aspd independently associated illicit aor confidence interval injection drug use aor sexual risk lcas suggested high risk aspd likely experience morbid mental disorders aspd comorbid disorders linked drug sex risk conclusions sti hiv prevention inmates incorporate diagnosis treatment aspd comorbid disorders interventions address aspd related factors impulsivity drive sti hiv risk
background researchers examined relationship mental health weather pollution mixed results current study aimed examine range weather atmospheric phenomena association time bound mental health data methods nineteen different weather pollution variables examined connection archive self reported mental health data university students participating mental health treatment using outcome questionnaire statistical approach involved randomly selecting subjects sample different times testing variable interest using mixed models analyses results seasonal changes sun time found best account relationships weather variables variability mental health distress increased mental health distress found periods reduced sun time hours separate analysis examining subjects endorsement suicidality item though statistically significant demonstrated similar pattern initial results showed relationship pollution changes mental health distress however mediated sun time limitations study examined relatively homogenous predominantly european american religious sample college counseling clients area subject inversions high altitude latitude sun time vacillates significantly locations closer equator conclusions seasonal increases sun time associated decreased mental health distress suggests need institutions public health entities plan intervention prevention resources strategies periods reduced sun time elsevier rights reserved
background responding joint attention rja reduced young children asd despite vital early development social communication reason rja frequent target early intervention programs clinical guidelines suggest exaggerating facial expressions gestural pointing may improve rja children autism clarifying meaning gaze gesture current study investigate effect intensity emotional expression rja preschoolers asd method twenty five preschoolers asd typically developing peers administered specifically designed eye tracking task actor directs attention moving object looking expression either neutral mildly surprised intensely surprised supplementary condition gestural pointing accompanied neutral gaze shift results commensurate previous studies children asd oriented less face actor less responsive rja compared typically developing peers however children autism differed response rja according different task conditions demonstrated frequent responses rja actor facial expression either intense supported gestural pointing conclusions report initial evidence importance clarifying content cues order help preschoolers autism adhere receptive joint attention rja opportunities findings inform knowledge early treatment attention emotional expressions autism improve understanding early interventions may work increase rja young children asd elsevier ltd rights reserved
background retinoblastoma typically diagnosed young children andmay present unique parenting challenges qualitative research suggests parents experience distress related initial diagnosis treatment subsequently resolves objectives systematically assess parenting stress time parents young childrenwith retinoblastoma examine associations parenting stress child outcomes procedures parents children retinoblastoma completed parenting stress index psi serial psychological assessments scheduled based child age months years caregivers patients mothers completed assessments child outcomes included developmental functioning parent reported adaptive functioning results baseline age subscales psi within normal limits significantly normative means demonstrating low levels stress domains remained relatively stable time associations parenting stress child outcomes much stronger age baseline child directed parenting stress small significant contributor declines child functioning time conclusions parents children retinoblastoma report normal levels parenting stress children young however baseline parenting stress appears contribute changes child functioning time future studies assess illness related aspects adjustment understand parenting experience young children cancer visually impaired child
background retrospective analyses demonstrated correlation patient reported allergies negative outcomes total joint arthroplasty sought validate observations prospective cohort methods one hundred forty four patients undergoing total hip arthroplasty patients undergoing total knee arthroplasty prospectively enrolled preoperatively patients listed allergies completed medical outcomes study short form charlson comorbidity index cci questionnaire mean months range months postoperatively cci western ontario mcmaster universities osteoarthritis index womac obtained telephone survey regression analysis used determine strength correlation patient age comorbidity burden number allergies outcome measurements results patients reported least allergy number allergies reported ranged penicillin derivative frequently reported allergy followed sulfa environmental allergen narcotic pain medication patients reporting least allergy significantly lower postoperative physical component score compared reporting allergies postoperative mental component score different groups multivariate regression analysis showed age patient reported allergies comorbidities independently associated worse postoperative physical component summary pcs womac score patients allergies experienced improvement pcs without allergy comorbidities correlate patient reported function postoperatively conclusion patients report allergies lower postoperative outcome scores may experience increment improvement total joint arthroplasty elsevier inc rights reserved
background reversible cerebral vasoconstriction syndrome rcvs clinicoradiologic syndrome characterized thunderclap headache reversible multifocal arterial constrictions resolves within months rcvs either spontaneous related trigger vasoactive drugs including counter medicine common culprits nevertheless sparse data association herbal supplements genesis unexplained rcvs methods describe case rcvs temporal association consumption diet pill composed green tea carnitine conjugated linoleic acid reviewed literature describing rcvs cases associated consumption herbal supplements plants results year old black woman presented emergency room thunderclap headache less week beginning new herbal supplement weight loss purpose angiographic study revealed multiple arterial constriction virtually intracranial territories reversed days later patient discharged minimal symptoms review identified previous reports herbal product related triggers conclusions different factors trigger rcvs besides case least nutraceutical products described associated disorders patients without clear cause clinicians aware possible role herbal supplements rcvs use systematically assessed large rcvs cohorts clarify association
background rheumatoid arthritis rheumatic conditions fundamentally affect patients quality life physiological needs also negatively associated work ability costs poor work ability sum treatment costs pose economic burden society patients work ability appears multifactorial symptoms pain swelling stiffness play major role directly affect functional disability also patients typically suffer reduced muscle strength lower extremity function grip strengths especially impair quality life however role muscle strength disease activity determinants work ability yet studied objective primary objective study compare work ability working age participants seropositive high low disease activity secondary objective evaluate association muscle strength functional ability frailty work ability methods monocentric cross sectional study conducted rheumatologic outpatient clinic day hospital approximately seropositive patients aged years clinical disease activity index measure rheumatoid disease activity assessed patients routine visits clinic work ability frailty functional disability evaluated self reported questionnaires well physical tests work ability index score health assessment questionnaire disability index survey health ageing retirement europe frailty instrument short physical performance battery muscle strength determined dynamometer measurements isometric hand grip strength quadriceps femoris muscle contraction strength sleep quality medical outcomes study sleep scale sexual functioning physiological needs additionally determined self reported questionnaires results study funding already awarded enrollment completed data currently evaluated conclusions study evaluate association work ability modifiable parameters muscle strength functional ability provide insights work ability associated risk factors evidence association motivate research findings might encourage interventions focused specifically improving muscle strength lower extremity function positively affect work ability
background rhinoconjunctivitis global health problem one common chronic conditions children development rhinoconjunctivitis depends genetic environmental factors many studies investigated rhinoconjunctivitis studies evaluated risk factors non allergic rhinoconjunctivitis children finding family history atopic diseases gender importance aim study investigate possible risk factors early life rhinoconjunctivitis allergic well non allergic adolescence methods children danish allergy research center cohort examined eight times birth years age visits included questionnaire based interview clinical examination skin prick test specific ige used univariate multivariate logistic regression investigate relationship early life risk factors development rhinoconjunctivitis allergic well non allergic adolescence results follow rate years prevalence rhinoconjunctivitis family history atopic diseases aor atopic dermatitis aor food allergy aor early sensitization inhalant food allergens aor aor male gender aor associated allergic rhinoconjunctivitis non allergic rhinoconjunctivitis early environmental tobacco exposure inversely associated rhinoconjunctivitis aor allergic aor well non allergic aor conclusion different patterns associations revealed stratifying rhinoconjunctivitis allergic non allergic suggesting allergic rhinoconjunctivitis non allergic rhinoconjunctivitis different phenotypes
background rosacea chronic inflammatory skin condition associated four distinct subtypes erythematotelangiectatic papulopustular phymatous ocular purpose review different kinds management subtypes methods divided rosacea management three main categories patient education skin care pharmacological procedural interventions results flushing better prevented rather treated avoiding specific triggers decreasing transepidermal water loss moisturizers blocking ultraviolet light nonselective beta blockers alpha adrenergic agonists decrease erythema flushing topical adrenergic receptor agonist brimonidine tartrate reduces persistent facial erythema intradermal botulinum toxin injection almost safe effective erythema flushing flashlamp pumped dye potassium titanyl phosphate pulsed dye laser intense pulsed light used telangiectasias metronidazole azelaic acid cream reduce severity erythema systemic topical remedies treat papulopustules systemic remedies include metronidazole doxycycline minocycline clarithromycin isotretinoin topical remedies based metronidazole azelaic acid sodium sulfacetamide ivermectin permethrin retinoid ocular involvement treated oral topical antibacterial rhinophyma corrected dermatosurgical procedures decortication various types lasers conclusion many options rosacea management patients may multiple subtypes phase treatment karger basel
background rotator cuff muscle degeneration important parameter consider planning shoulder arthroplasty hypothesis hypothesized rotator cuff muscle degeneration correlated scapulohumeral subluxation patients planned anatomical total shoulder arthroplasty tsa materials methods developed semi automated quantitative method measure rotator cuff muscle degeneration retrospectively analyzed preoperative shoulder scans patients primary osteoarthritis standardized sagittal oblique slice perpendicular scapular axis two observers measured cross sectional areas residual rotator cuff muscle tissues normalized estimated area healthy muscles muscle degeneration quantified semi automated manner divided atrophy fatty infiltration scapulohumeral subluxation determined distance humeral head center glenoid surface center projected slice normalized humeral head radius tested potential correlations muscle degeneration scapulohumeral subluxation results muscle degeneration primarily due atrophy predominated supraspinatus varied scapulohumeral subluxation varied mainly posterior postero superior orientation significant weak correlation amount subluxation supraspinatus infraspinatus degeneration inter intra observer reproducibility muscle degeneration measurements excellent iccs range respectively conclusion new semi automated method allows quantitatively reproducibly measure rotator cuff muscle degeneration shoulders primary osteoarthritis muscle degeneration weakly correlated scapulohumeral subluxation patients planned anatomical tsa level evidence level type study diagnostic retrospective study elsevier masson sas rights reserved
background salome study assess longer term opioid medication effectiveness tested double blind non inferiority clinical trial hydromorphone could effective diacetylmorphine severe opioid use disorder although participants guess treatment correctly beyond expected chance perceived treatment assignment could affect patients response treatment study tested treatment allocation guess associated treatment outcomes identified predictors guess methods data obtained questionnaires clinical records participants asked medication thought receiving diacetylmorphine hydromorphone unsure open ended reasons multinomial logistic regression used assess predictors treatment guess inductive thematic analysis used code open ended responses clinical trial registered national institutes health https clinicaltrials gov show nct findings participants referred prior experiences opioids presence absence specific drug effects reasons guesses differences illicit opioid use retention guess however guessed diacetylmorphine better physical mental health scores participants treatment related observed drowsiness event higher perceived drug related high scores likely guess diacetylmorphine compared hydromorphone guessing hydromorphone likely among made negative comments reasons treatment guesses conclusions understanding clues participants use treatment allocation guesses relating treatment expectations could integrated accurate information treatment providing opportunity patient physician shared decision making opioid maintenance treatment clinical trial registration national institutes health clinicaltrials gov identifier nct https clinicaltrials gov show nct
background selective serotonin reuptake inhibitors ssris serotonin norepinephrine reuptake inhibitors snris widely prescribed mood anxiety disorders however clear whether snris strongly associated cardiovascular cerebrovascular events ssris methods propensity score matched population based cohort study manitobans started ssri snri april march primary outcomewas composite acute myocardial infarction ami stroke cardiovascular related hospitalization within year drug initiation component primary outcome death analyzed separately secondary analyses results total patients initiated treatment ssri snri respectively propensity score matching higher risk observed primary outcome among snri users weighted hazards ratio confidence interval secondary analyses showed risk nonfatal stroke higher among snri users weighted risk death higher among snri users without mood anxiety disorders weighted differences observed risk ami fatal stroke ssri snri use conclusions new snri use associated higher risk nonfatal stroke relative ssri use investigation warranted regarding higher risk death observed subgroup analysis among incident snri users without mood anxiety disorders
background selenium reported protect neurotoxicity mercury however effect cardiovascular diseases remains unclear inuit living arctic high exposure marine mammal fish rich traditional diet objective characterize exposure among inuit canada assess associations cardiovascular health outcomes including stroke hypertension myocardial infarction methods data collected international polar year inuit health survey ihs conducted blood measured self report cardiovascular health outcomes collected questionnaire interview adults aged results mean age years participants male geometric means blood total respectively crude prevalence heart attack stroke hypertension respectively participants categorized exposure groups according blood high low low odds ratio cardiovascular outcomes estimated using general linearized models results showed low high group higher prevalence cardiovascular disease hypertension stroke however prevalence decreased high low group hypertension stroke high high group hypertension stroke conclusions high low group lowest prevalence cardiovascular outcomes except stroke results provide evidence may exhibit protective effect cardiovascular disease elsevier ltd rights reserved
background serpina gene implicated pathogenesis chronic obstructive pulmonary disease copd smoking known risk factor copd little known effect serpina gene interaction smoking chinese population study effect serpina gene polymorphisms copd risk interaction smoking status investigated method total copd patients healthy controls recruited armed police corps hospital data demographic variables smoking status history occupational dust exposure allergies collected genotyping single nucleotide polymorphism snp performed participants results snp genotype associated significantly higher risk copd odds ratio confidence interval whereas snps exhibit association smoking habit also significantly increased risk copd stepwise logistic regression analysis advanced age smoking snp variant associated increased risk copd female gender higher educational status decreased risk additive interaction analysis significant interactive effect snp smoking observed population relative excess risk due interaction attributable proportion due tointeraction conclusion snp serpina gene significantly interacted smoking status associated higher risk copd chinese population
background several studies shown antimuscarinic treatment overactive bladder characterized low long term persistence rates investigated persistence solifenacin real life means telephonic interviews prospective cohort included patients idiopathic overactive bladder well neurogenic overactive bladder methods june july patients idiopathic neurogenic overactive bladder newly prescribed solifenacin included total subjects followed prospectively one year means four telephonic interviews included questions medication use adverse events results one year patients included still using solifenacin discontinued lost follow neurogenic group still using solifenacin versus idiopathic group one year main reasons stop solifenacin lack efficacy side effects combination conclusions prospective cohort study showed real life continuation rate months continuation rate higher found studies use regular telephonic evaluation might improved medication persistence findings study also suggest patients neurogenic overactive bladder better persistence method evaluation compared patients idiopathic overactive bladder
background sexual dimorphism blood pressure associated differential expression angiotensin aii receptors activity nervous system generally accepted ageing affects kidney function well autonomic nervous system hormonal balance given hypertension prevalent men women women reach seventh decade hypothesised females would relatively protected adverse effects ageing compared males would mediated protective effect ovarian steroids methods intact gonadectomised male female normotensive wistar rats aged months used study renal function blood pressure heart rate blood pressure variability results observed intact females lower levels proteinuria higher creatinine clearance compared intact males difference abolished castration ovariectomy ovariectomy resulted change heart rate resulting similar cardiovascular parameters observed males gonadectomised males spectral analysis systolic blood pressure revealed high frequency power spectra significantly elevated females males reduced ovariectomy conclusions taken altogether results show females protected age related declining renal function lesser extent rising blood pressure comparison males whilst ovariectomy deleterious effects females strongest effects associated gonadectomy males suggesting damaging effect male hormones
background sexual dysfunction common among women reproductive age many use contraception various contraceptive methods associated changes sexual function methods narrative review selected key articles based collective clinical experience summarized findings best practice recommendations addressing woman contraception potential relationship sexual function results although hormonal contraception associated sexual dysfunction studies show mixed results based route administration progestin component interestingly nonuse contraception also appears associated sexual dysfunction dissatisfaction low dose vaginal estrogen lubricants moisturizers may used treating vaginal dryness setting hypoestrogenic states reproductive age women conclusion review current contraception appropriate women presenting sexual health concerns sexual dysfunction chronologically associated contraceptive may addressed trial alternative method multidisciplinary approach treatment recommended including sex therapy pelvic floor physical therapy consultation women health specialist needed
background sezary syndrome characterized erythroderma leukemic involvement atypical leukemic involvement present without erythroderma little known presentation prognosis outcome patients objective sought describe experience patients without erythroderma methods retrospectively identified patients without erythroderma mayo clinic patients met criteria high blood tumor burden clinical characteristics disease course prognosis reviewed compared previously described cohort patients institution results among patients identified cutaneous findings consistent cutaneous cell lymphoma commonly erythematous patches plaques patients deceased time study median time diagnosis without erythroderma date death years range years survival different patients without erythroderma hazard ratio confidence interval limitations single institution retrospective study conclusion leukemic involvement may confer shortened survival patients presence erythroderma affect survival atypical cases could potentially accurately described using tnmb classification
background shared decision making cornerstone patient centred care item shared decision making questionnaire sdm brief self assessment tool measuring patients perceived level involvement decision making related treatment care information related psychometric properties sdm multiple sclerosis patients limited objective study assess performance items composing sdm dimensional structure patients relapsing remitting methods non interventional cross sectional study adult patients relapsing remitting conducted units throughout spain nonparametric item response theory irt analysis used assess latent construct dimensional structure underlying observed responses parametric irt model general partial credit model fitted obtain estimates relationship latent construct item characteristics unidimensionality sdm instrument assessed confirmatory factor analysis results total patients studied mean age years female median expanded disability status scale score patients reported taking part step decision making process internal reliability instrument high cronbach alpha overall scale scalability score indicative strong scale items except item showed scalability indices higher four items items conveyed half sdm overall information sdm good fit unidimensional latent structure comparative fit index root mean square error approximation freely estimated parameters statistically significant exception item presented lowest loading items relevant items shared decision making conclusions sdm presents appropriate psychometric properties therefore useful assessing different aspects shared decision making patients multiple sclerosis
background shared genetic influences attention deficit hyperactivity disorder adhd symptoms autism spectrum disorder asd symptoms reported cross trait genetic relationships however subject dynamic changes development investigated continuity genetic overlap asd adhd symptoms general population sample childhood adolescence also studied uni cross dimensional trait disorder links respect genetic adhd asd risk methods social communication difficulties social communication disorders checklist scdc combined hyperactive impulsive inattentive adhd symptoms strengths difficulties questionnaire sdq adhd repeatedly measured birth cohort alspac age years genome wide summary statistics clinical asd cases pseudo controls adhd cases controls pseudo controls available psychiatric genomics consortium genetic trait variances genetic overlap phenotypes estimated using genome wide data results general population genetic influences scdc sdq adhd scores shared throughout development genetic correlations across traits reached similar strength magnitude cross trait min repeated measures trait within trait min shared genetic influences traits especially later adolescence may implicate variants ras signalling upregulated genes meta uni dimensionally population based trait mapped expected behavioural continuum risk increasing alleles clinical adhd persistently associated sdq adhd scores throughout development marginal regression age specific genetic overlap clinical asd social communication difficulties childhood also shown per previous reports cross dimensionally however neither scdc sdq adhd scores linked genetic risk disorder conclusions general population genetic aetiologies social communication difficulties adhd symptoms shared throughout child adolescent development may implicate similar biological pathways vary development within asd adhd dimension population based traits also linked clinical disorder although much larger clinical discovery samples required reliably detect cross dimensional trait disorder relationships
background signal transduction inhibitors stis considerably improved treatment advanced metastasized renal cell carcinoma mrcc safety data drugs derived clinical trials purpose study evaluate adverse drug reactions documented first line treatments routine clinical practice patients methods ongoing prospective german mrcc clinical registry recruiting patients oncology urology outpatient centers data first patients completed first line treatment analyzed regarding adverse drug reactions adrs documented patients medical records results patients older clinical trials comorbidities patients treated stis sunitinib temsirolimus sorafenib bevacizumab combined interferon adrs documented resulted treatment modifications frequently affected organ system gastrointestinal system frequently documented adrs mucositis stomatitis fatigue diarrhea nausea conclusions routine practice mrcc first line treatments using stis frequently lead adrs partly necessitating treatment modifications pattern reported adrs similar reported clinical trials frequencies events differ especially symptoms multifactorial origin immediately associated treatment results indicate perception documentation adverse reactions different clinical trials routine practice reviews patients medical records might best method assess safety routine practice
background skin skin care immediately following delivery common practice term infants shown improve cardiorespiratory stability facilitate early bonding promote breastfeeding since use skin skin care practiced preterm infants weeks gestation delivery room olav university hospital present study aim investigate whether skin skin care following delivery safe affects early late outcomes compared standard care preterm infants methods design randomized controlled trial rct skin skin care delivery room preterm infants born gestational age weeks birth weight grams infants severe congenital malformations need intubation delivery room excluded detailed checklist flowchart prepared study involved professionals neonatologists neonatal nurses obstetricians anesthesiologists midwives participated medical simulation training prior study start february consultant neonatology neonatal nurse present deliveries infants birth weight grams receive intravenous line glucose amino acids caffeine citrate delivery room infants gestational age weeks routinely put continuous positive airway pressure cpap initial stabilization infants randomized skin skin care transferred nursery incubator primary outcome cognitive development years measured bayley scales infant development third edition secondary outcomes safety defined hypothermia respiratory failure cardiopulmonary resuscitation physiological stability birth motor language cognitive development year child mental health measured state trait anxiety inventory stai discharge months years expected date delivery mothers discussion study may important implications initial care preterm infants delivery increase understanding early skin skin care affects preterm infants mothers
background sleep disorder sleep complaints common subjects migraine although association sleep disorders migraine reported association perceived insufficient sleep migraine rarely reported aim study evaluate association insufficient sleep migraine using data korean headache sleep study khss methods khss nation wide cross sectional population based survey regarding headache sleep korean adults aged years difference one hour sleep need average sleep time indicated insufficient sleep results participants individuals classified insufficient sleep prevalence insufficient sleep among individuals migraine significantly higher compared among individuals non migraine headache among non headache average sleep time differ among migraine non migraine headache non headache groups multivariable logistic regression analyses demonstrated migraine increased odds ratio insufficient sleep adjusting sociodemographic variables short sleep time insomnia poor sleep quality anxiety depression confidence interval conclusions prevalence insufficient sleep significantly higher among migraineurs compared non migraine headache non headache group
background sleep disturbance common symptom patients positively related greater somatic psychiatric symptoms methods participants adult outpatients measures constipation constipation scoring system css patient assessment constipation symptoms pac sym sleep pittsburgh sleep quality index psqi anxiety general anxiety disorder gad depression patient health questionnaire phq qol patient assessment constipation quality life pac qol patients divided sleep disorder normal sleep groups psqi scores results sleep disorder group significantly higher rates incomplete defecation blockage higher css scores pac sym total scores pac sym rectal item scores normal sleep group gad phq scores significantly higher patients poor sleep furthermore sleep disorders depression anxiety positively correlated constipation severity worry anxiety score pac qol scale significantly higher scores seven subscales significantly lower patients poor sleep addition correlation analyses showed significant negative relations qol constipation sleep disturbance anxiety well depression however multiple regression revealed pac qol positively associated severe constipation negatively associated anxiety depression sleep disturbance independent risk factor qol patients conclusion sleep disorders may worsen physical mental health patients sleep disturbance may lower patients qol indirectly combined effects anxiety depression constipation
background sleep disturbance commonly reported following traumatic brain injury tbi adversely impact health wellbeing interfere rehabilitation process effective treatment sleep disturbance critical overall recovery sleep hygiene non invasive low cost low risk could serve suitable first line treatment individuals experiencing sleep disturbance post tbi objective assess efficacy sleep hygiene sleep outcomes post tbi design psycinfo medline embase databases systematically searched using mesh terms keywords related traumatic brain injury sleep treatment studies met inclusion criteria assessed methodological quality using validated assessment tools results ten studies met inclusion criteria none contained child adolescent population methodological quality varied following interventions shown improve sleep outcomes amongst adults tbi cognitive behaviour therapy insomnia blue light therapy problem solving treatment combined sleep hygiene prazosin mixed evidence efficacy exercise sleep outcomes conclusion preliminary findings suggest sleep hygiene related interventions either isolation combination treatments may reduce sleep difficulties post tbi
background sli dysfunction defined difficulties acquiring one native language ones appear primary apart language code two codes play significant part process communication paralinguistic nonlinguistic code often described together nonverbal communication goal research find answers question ability recognize facial vocal expression emotion follow course children sli contemporaries typical development speech tds material methods study conducted children typical development speech children sli aged years employed experimental method called emotional recognition czaplewska results ability recognize signs facial expressions emotion increases age children sli achieve similar optimal results peers tds sli recognized better children tds vocal signs emotion case called contradictory messages children tds important receiving message content children sli nonverbal signs emotion conclusions results studies cast doubt suggestion source problems children sli symbol meaning relation also social dimensions context speaking rather appears problems language acquisition contribute difficulties social learning
background social connections important transition parenthood wide body literature suggests connections enhance health contribute wellbeing case parents families social connections influence child development nurses public health agencies unique position advocate resources approaches enhance social connectivity parents important life transition objectives aim review identify universal social connectivity interventions work conditions foster social connections parents enhance child development review undertaken part larger research project inform question population level interventions public health implement promote social emotional cognitive development prenatal period end first year life social connectivity one three domains explored full study design realist synthesis data sources medline cinahl eric socabs psychinfo grey literature review methods literature search conducted using relevant key words mesh headings nearly papers reviewed title sorted based inclusion exclusion criteria data extraction aided quality appraisal analysis informed development explanatory mechanism results twenty seven papers included synthesis findings described four theme areas connections community internet connections prenatal connections connections fathers literature available answer research question scant varying quality community development family systems intervention practices principles father inclusive practice group prenatal care models demonstrated foster social connectivity parents online social networking provides valuable informational support conclusions changing social structures technology influenced way new parents access support social connections fostered parenting environment potential enhance wellbeing parents thus contribute children positive development nurses position advocate use evidence informed approaches planning programs services parents authors published elsevier inc
background soleus muscle injuries common different sports disciplines time required recovery often difficult predict reinjury common length recovery time might influenced different variables involved part muscle hypothesis injuries central aponeurosis worse prognosis injuries lateral medial aponeurosis well myofascial injuries study design case series level evidence methods total high level professional athletes several sports disciplines soccer tennis track field basketball triathlon field hockey reviewed prospectively determine recovery time soleus muscle injuries clinical magnetic resonance imaging evaluation performed soleus muscle injuries association different characteristics typical muscle sites including anterior posterior myofascial lateral central medial aponeurosis disruption well injury recovery time determined recovery time correlated age sport extent edema volume cross sectional area retraction extension gap results patients muscle injuries analyzed strains affecting myotendinous junction strains myofascial junction injuries involving myotendinous medial mtm affecting central mtc lateral mtl myofascial anterior mfa myofascial posterior mfp median recovery time injuries days statistically significant differences myotendinous myofascial injuries regarding recovery time site worst prognosis mtc aponeurosis mean recovery time days site best prognosis mtl amean recovery time days statistically significant correlation recovery time age recovery time extent retraction conclusion wide variation exists among different types soleus injuries corresponding recovery time return level competitive sports injuries central aponeurosis significantly longer recovery time injuries lateral medial aponeurosis myofascial sites
background spasticity multiple sclerosis results imbalance inputs descending pathways spinal motor circuits well damage corticospinal tract cst objectives assess cst impairment patients without spasticity evaluate evolution sativex treatment methods ten patients spasticity cases underwent clinical edss hole peg ashworth scale timed foot walk nrs spasticity mri cst fractional anisotropy electrophysiological central motor conduction time cmct ratio evaluations baseline months selected patients without spasticity control group baseline results baseline cases showed lower cst higher cmct compared control group correlations found clinical electrophysiological mri features months cases showed decrease non prevalent degree impairment pdi side without differences electrophysiological features compared baseline treatment sativex resulted reduction nrs spasticity conclusions confirm presence cst impairment patients spasticity identify structural electrophysiological correlates could explain sativex clinical effect
background specific knowledge urinary incontinence interrelation physical cognitive health essential working towards prevention improving quality treatment care purpose study determine association activities daily living adl hierarchy scale cognitive performance scale cps comorbid conditions methods cross sectional retrospective analysis nursing homes switzerland based data minimum data set resident assessment instrument rai mds analysis examined effect adl hierarchy scale cps joint motion comorbidities women years included january september time admission nursing home statistical analysis done means descriptive statistics logistic regression analysis results prevalence mean adl hierarchy scale range mean cps range gradual increase odds ratio depending adl hierarchy scale hierarchy scales supervised total dependence cps borderline intact severe impairment considering interaction adl cps adl hierarchies remained significantly associated however cps case lower hierarchies examined comorbid conditions diabetes mellitus dementia arthrosis arthritis significantly associated conclusion study indicated impairment adl performance strongly associated cps performance comorbidities physical cognitive training order improve least stabilize adl performance could way prevent reduce process developing
background spinal cord pathology important substrate long term disability multiple sclerosis objective investigate longitudinal changes spinal cord lesions atrophy patients non spinal clinically isolated syndrome cis relate development disability methods patients non spinal cis brain spinal cord imaging time cis approximately years later median years range years brain magnetic resonance imaging mri measures consisted hyperintense hypointense lesion loads plus brain atrophy spinal cord mri measures consisted lesion number upper cervical cord cross sectional area ucca disability measured using expanded disability status scale edss multiple linear regression used identify independent predictors disability years results follow patients diagnosed baseline spinal cord lesion number change cord lesion number change ucca independently associated edss follow including brain lesion load brain atrophy modestly increased predictive power model conclusion asymptomatic spinal cord lesions spinal cord atrophy contribute development related disability first years non spinal cis
background spinal cord stimulation scs improves microcirculatory blood flow relieves ischemic pain reduces amputation rate patients severe peripheral arterial occlusive disease aim evaluate transcutaneous oxygen tension tcpo measurements specific prognostic parameter prediction permanent device implantation prospective controlled study patients lower limb ischemia methods patients men women mean age years range years submitted implantation spinal cord electrical generator rest pain trophic lesions dry gangrene severe lower limb ischemia failed conservative surgical treatment clinical status classified fontaine stages iii main pathology essentially due atherosclerosis diabetic vascular disease pedal transcutaneous oxygen tension tcpo ankle toe pressure doppler measurements performed weeks weeks implantation results months follow pain relief limb salvage achieved patients patients partial success pain relief limb salvage obtained least months patients method failed patients limbs amputated tcpo assessed dorsum foot clinical improvement scs success associated increase tcpo within first weeks implantation temporary period limb salvage achieved patients presented significant tcpo increase within first weeks testing period mmhg mmhg patients rest pain mmhg mmhg trophic lesions mmhg mmhg independently stage disease initial tcpo value tcpo changes related presence adequate paresthesias warmth painful area trial period systolic ankle brachial blood pressure index change stimulation conclusions patients failed conservative surgical treatment severe critical lower limb ischemia scs increases skin blood flow associated significant pain relief could prove excellent alternative therapy improves quality life also demonstrate tcpo increase within test period weeks predictive index scs therapy success considered terms cost effect final decision permanent implantation
background stress anxiety identified significant issues experienced student nurses education studies suggested stress experienced nursing students greater experienced medical students non nursing healthcare students degreed nurses female population general recently introduced energy type therapy emotional freedom technique eft shown success reducing symptoms anxiety stress fear variety settings objective purpose study determine efficacy eft decreasing anxiety stress potential intervention assist students stress management design study used mixed method design qualitative quantitative measures quantitatively one group pretest posttest design participants received group instruction technique encouraged repeat daily self reported anxiety measured baseline weekly four weeks using perceived stress scale pss state trait anxiety inventory stai qualitative survey completed participants end study order capture subjective experience setting pilot study conducted two year college southeastern region united states participants enrolled nursing students associate degree nursing program invited participate participation voluntary resulting original convenience sample thirty nine nursing students methods data collection instruments included demographic questionnaire pretest state trait anxiety inventory stai perceived stress scale pss qualitative questionnaire also administered end four weeks stai pss administered weekly data analysis using rmanova performed second third fourth week results decreases anxiety measured stai pss statistically significant pss stai state trait data reduction self reported stress statistically significant mean difference baseline week qualitative data suggested nursing students experienced decrease feelings stress anxiety including decrease somatic symptoms conclusions overall findings suggested eft effective tool stress management anxiety relief nursing students elsevier ltd rights reserved
background strontium zinc potassium salts demonstrated inhibit irritation inflammation applied topically particularly strontium chloride potassium nitrate reported reduce skin tooth sensitivity aim present study compare anti irritant effects four inorganic salts assign ingredient suppress skin irritation due chemical environmental exposure effectively compared anti inflammatory effects strontium nitrate zinc chloride materials methods double blind trial conducted healthy volunteers sensitive skin irritation induced exposure sodium lauryl sulfate arms treatments applied ointment hexahydrate concentrations prepared dosage twice daily days irritated areas skin reactions evaluated instrumentally results beneficial effect significant overall treatments exert protective effect skin barrier function significantly exception test substances improved skin hydration effect significant respect colorimetric assessment treatments excluding reduced erythema significantly compared untreated control days treatment start support dose response effect conclusion analysis biometric measurements revealed strontium salts best treating worst little difference treatments hence skin care products containing may reduce signs symptoms irritant contact dermatitis
background studies aiming identify palliative care populations used data death certificates cases hospital records size characteristics identified populations show considerable variation depending data sources used important service planners researchers aware aim illustrate differences size characteristics potential palliative care population depending differential use linked hospital records death certificate data design retrospective cohort study setting participants cohort consisted people aged years died western australia january december excluding deaths related pregnancy trauma within cohort number proportion characteristics people died one medical conditions considered amenable palliative care identified using linked hospital records death certificate data results depending information source used people died condition potentially amenable palliative care identified median age death sex distribution decedents condition also varied information source conclusion health service planners researchers need aware limitations using hospital records death certificate data determine potential palliative care population use emergency department administrative data sources could exacerbate variation
background studies pathophysiology comorbidities associated lichen planopilaris lpp frontal fibrosing alopecia ffa limited objective purpose study determine prevalence androgen excess postmenopausal lpp population relation demographics comorbidities methods retrospective data analysis patients lpp ffa lpp ffa seen department dermatology cleveland clinic foundation ohio conducted cohort patients met inclusion criteria results androgen excess identified patients lpp subtypes androgen deficiency identified patients ffa androgen excess group significantly likely present hirsutism seborrheic dermatitis polycystic ovary syndrome ovarian cysts combination limitations study limited retrospective conclusion study demonstrated lpp associated androgen excess ffa associated androgen deficiency
background sub saharan africa heavily dependent global health initiatives ghis funding antiretroviral therapy art scale indications global investments art scale flattening unclear new funding channels bridge funding gap art service delivery many previous studies focused domestic government spending international funding especially ghis objective study identify funding strategies adopted health facilities uganda sustain art programs explore variations financing mechanisms ownership health facility methods mixed methods approach employed survey health facilities across uganda commenced art delivery conducted six health facilities purposively selected depth examination semi structured interviews conducted art clinic managers three six health facilities statistical analyses performed stata version qualitative data analyzed coding thematic analysis results multiple funding sources art programs common health facilities indicating least two concurrent grants supporting art service delivery private philanthropic aid emerged important source supplemental funding art service delivery art financing strategies differentiated ownership health facility private profit providers externally focused multiple grants philanthropic aid profit providers client oriented fee service insurance schemes public facilities sought additional funding streams dissimilar health facility ownership types conclusion year study period health facilities uganda diversified funding sources art service delivery identified alternative funding mechanisms could reduce dependence ghi funding increase local ownership hiv programs research evaluating potential contribution identified alternative financing mechanisms bridging global hiv funding gap recommended
background suicide major public health concern particularly among people use illicit substances non prescribed medications methods present study prospectively assessed incidence predictors suicidal ideation suicide attempt among substance using patients months receiving primary care within seven public primary care clinics results participants reported high incidence year following primary care visits suicidality elevated patients female lacked high school diploma unemployed reported depression anxiety hallucinations concentration difficulty violent behavior used nicotine stimulants used emergency department mental health services past days reported current quality life impairment mobility usual activities reported recent lifetime baseline multiple regression analyses past day lifetime past day violent behavior current impairment due anxiety depression baseline uniquely predicted beyond variables conclusions results support need screening suicidality among primary care patients use illicit substances identify key patients particularly elevated risk suicidality
background suo quan wan sqw effective traditional chinese prescription treated lower urinary tract symptoms luts proved modulation effect expression transient receptor potential vanilloid trpv accordance recovery bladder function overactive bladder rat study investigated mechanism sqw modulated trpv signaling bladder function using trpv knockout mice methods study conducted using wild type trpv mice animals grouped group sqw treated group applied vivo cystometrogram recording techniques analyze voiding control urinary bladder well vitro organ bath study bladder distension response various compounds subsequently elicited normal smooth muscle excitation real time polymerase chain reaction western blot analysis performed quantify expression trpv bladder atp released bladder strips measured using luciferin luciferase atp bioluminescence assay kit results preparation inhibited decrease micturition times micturition interval volume increased results urodynamic record trpv mice infusion showed reduced bladder pressure contraction exhibited decreased response atp kcl carbachol response cap atp released trpv mice strips bladder smooth muscles significantly reduced along trpv expression reduced expression level bladder sqw could increase atp release degree effect trpv expression sqw could improve bladder pressure slightly make significantly effects force response meatp cap carbachol gradient concentration kcl well mbc voiding activities conclusions trpv plays important role urinary bladder mechanosensitivity effective sqw hard play proper role bladder function mice without trpv
background support self management ssm prominent strand health policy internationally particularly primary care often discussed evaluated terms patients knowledge skills confidence health related behaviours disease control risk reduction service use costs however goals limited guides professional practice indicators quality order better understand means support self management well examined health professionals views success work people long term conditions study formed part broader project develop conceptual account ssm reflect promote good practice methods semi structured individual interviews subsequent group discussions groups participants diverse health professionals working people diabetes parkinson disease nhs services london northern england scotland interviews explored examples less successful work ways defining success ideas facilitates success practice subsequent group discussions considered practical implications different accounts ssm interviews group discussions audio recorded transcribed analysed thematically results participants identified wide range interlinked aspects elements success relating health wellbeing quality life well people manage professional patient relationships also mentioned number considerations important implications assessing quality performance considerations part reflect variations matters realistically achievable particular people particular situations particular times well complexity questions attribution conclusions nuanced assessment quality support self management requires attention responsiveness professional practice wide complex range personal situational states well actions interactions time narrow focus particular indicators lead insensitive even perverse judgements perhaps counterproductive effects open critical discussions success assessment quality needed facilitate good professional practice service improvement initiatives
background supraspinatus tears common pitchers however effect tears glenohumeral mechanics incompletely understood purpose hypothesis describe effect supraspinatus tears repairs kinematics abbreviated throwing motion using intact shoulder girdle hypothesis supraspinatus tears would lead increase translation coronal plane supraspinatus repairs would restore kinematics study design controlled laboratory study methods six shoulders fresh frozen cadavers tested novel degrees freedom robotic testing system torsos mounted wrist pinned actuator mounted upper frame deltoid removed shoulders studied abbreviated throwing motion atm maximum external rotation midcoronal plane establish baseline atm repeated creation supraspinatus tear creation supraspinatus tear repair transosseous equivalent toe technique retroreflective bone markers high speed infrared cameras used measure kinematics calculate center rotation joint corgh instantaneously results supraspinatus tears significantly alter translation toe repair shifted corgh posteriorly evidenced significant decrease overall translation planes planes respectively conclusion contrast toe repair supraspinatus tendon isolated supraspinatus tears perturb kinematics cadaveric model throwing shoulder clinical relevance throwing athletes treatment rotator cuff tears addressed caution avoid unintended alteration kinematics due overtightening tendon
background survivors childhood non hodgkin lymphoma nhl increased risk chronic health conditions objective study characterize health conditions neurocognitive function physical performance among clinically evaluated cohort childhood nhl survivors method chronic health neurocognitive conditions graded per modified version national cancer institute common terminology criteria adverse events ctcae impaired physical function defined performance percentile normative data multivariable regression used investigate associations sociodemographic characteristics therapeutic exposures outcomes results survivors median age years range diagnosis years range evaluation eighty eight received radiation cranial radiation high dose methotrexate prevalent ctcae grades severe life threatening conditions obesity hypertension impairment executive function attention memory many impaired strength flexibility muscular endurance mobility demographic treatment related factors associated development individual chronic diseases functional deficits conclusions clinical evaluation identified high prevalence chronic health conditions neurocognitive deficits performance limitations childhood nhl survivors
background suspected child physical abuse sexual abuse neglect uncommon presentations part assessment cases forensic medical history may taken forensic history used determine steps necessary address child wellbeing also direct forensic examination currently clear consensus whether forensic medical history consistently considered integral element within paediatric forensic evaluation study examines value derived medical practitioner taking forensic medical history rather relying hearsay evidence child presents assessment methods retrospective review paediatric cases seen victorian forensic paediatric medical service vfpms undertaken forensic case reports reviewed data entered excel spread sheet analysed using chi squared tests within stata results increasing age child forensic medical history significantly likely taken additional information made available medical practitioner would otherwise provided medical practitioner relied interview conducted police discrepancies observed official third parties police child protection report child said child says medical practitioner decrease age discrepancies observed child version events third party parents caregivers friends version events conclusions study showed taking forensic medical history child additional information obtained value examining medical practitioner taking forensic medical history children cases child physical sexual abuse neglect elsevier ltd faculty forensic legal medicine rights reserved
background teens young adults united states need sexual reproductive health information evidenced elevated rates sexually transmitted infections stis pregnancy births among population person sexuality education programs helpful unlikely rapidly accommodate teens young adults moment crisis evidence suggests technologies instant messaging text messaging may effective ways provide teens young adults sexual reproductive health information september planned parenthood federation america launched text program designed provide immediate answers urgent sexual reproductive health questions reliable confidential source link young people sexual reproductive health services needed objective assess whether program successful reaching target population whether user characteristics vary mode text whether mode associated reaching individuals high levels worry reducing worry postchat methods data collected prechat postchat surveys text message conversations september august bivariate analysis conducted using chi square tests differences main covariates mode conversation multivariable analysis logistic regression used identify factors independently associated prechat levels worry changes worry postchat results total conversations occurred program first year odds feeling worried prechat highest users adjusted odds ratio aor users years younger aor latino hispanic users aor black users aor controlling study covariates significant difference odds feeling better less worried postchat text message users feeling better postchat associated younger years aor years aor latino hispanic aor reporting service helpful aor asking emergency contraception aor odds feeling better lowest users questions stis aor conclusions results process evaluation suggest program able provide informational support vulnerable groups teens racial minorities moments particular worry differences text message users reveal mode appeals different population necessary reach diverse audience
background testosterone deficiency patients heart failure associated decreased exercise capacity mortality however impact hospital readmission rate uncertain furthermore relationship testosterone deficiency sympathetic activation unknown objective investigated role testosterone level hospital readmission mortality rates well sympathetic nerve activity patients methods total testosterone free testosterone measured hospitalized male patients left ventricular ejection fraction new york heart association classification patients placed low testosterone normal testosterone groups hypogonadism defined pmol muscle sympathetic nerve activity msna recorded microneurography subpopulation patients results length hospital stay longer group compared group days similarly cumulative hazard readmission within year greater group compared group single predictor analysis hazard ratio confidence interval predicted hospital readmission within days addition readmission within days predicted increased mortality neurohumoral activation estimated msna significantly higher group compared group bursts heart beats conclusion results support concept independent risk factor hospital readmission within days increased mortality patients furthermore increased msna observed patients
background alpha alkylated derivatives testosterone often used prevention oedematous episodes hereditary angioedema inhibitor deficiency inh hae however agents many adverse effects including erythrocytosis polyglobulia aim investigate occurrence erythrocytosis polyglobulia long term danazol prophylaxis inh hae methods initial stage retrospective study explored whether inh hae associated susceptibility erythrocytosis polyglobulia second stage analyzed haematological parameters inh hae patients well treatment danazol years third stage studied incidence erythrocytosis polyglobulia dosing danazol years results find significant difference inh hae patients receiving danazol healthy controls regards occurrence erythrocytosis polyglobulia haematological parameters change treatment danazol years platelet count exception decreased significantly versus baseline within reference range treatment related polyglobulia occur observed erythrocytosis single female patient year three female patients year long treatment danazol erythrocytosis require intervention discontinuation danazol therapy conclusions conclude neither erythrocytosis polyglobulia occurs often inh hae patients healthy individuals observed sporadically even treatment danazol
background accurate reliable measurement foot bone density challenging currently gold standard technique measurement particularly valuable populations risk foot bone pathology long term diabetes research development computed tomography may prove useful tool assessment aim study establish reliability novel method foot bone density measurement people diabetes using computed tomography methods ten feet people diabetes scanned computed tomography twice repositioning bone density hounsfield units assessed trabecular cortical bone tarsals metatarsals reliability assessed intra class correlation coefficients confidence intervals limits agreement standard error measurement results reliability trabecular density bones excellent intra class correlation coefficients ranging additionally cortical bone density showed fair good reliability talus calcaneus navicular cuboid intermediate cuneiform first metatarsal conclusions study established reliability practical method assessing trabecular cortical foot bone density using computed tomography scanning methodology may useful investigation foot bone disease occurring diabetes early diagnosis intervention assessment treatment efficacy development method warranted
background aim study describe clinical features children adolescents celiac disease assess presenting symptoms vary age sex methods cross sectional study total known cases patients males females diagnosed namazi hospital large referral center south iran census studied detailed data clinical features associated disorders patients assessed based medical records also clinical examination two groups made per age patients time diagnosis groups less equal years old years old resultlts mean age diagnosis years growth failure abdominal pain frequent presenting features diarrhea common females common presenting features group growth failure abdominal pain anorexia group growth failure short stature abdominal pain cases convulsion male abdominal distention anxiety common among female participants frequently associated disorder diabetes mellitus type patients conclusions considered children adolescents growth failure short stature even absence gastrointestinal symptoms especially diarrhea
background aim study investigate possible association repeat polymorphism interleukin receptor antagonist gene ilrn quantitative ultrasound qus parameters calcaneus korean males interaction nutritional factor environmental factor methods several qus parameters including broadband ultrasound attenuation bua sound speed sos measured using ultrasound bone densitometer calcaneus korean males mean age year study group divided non vegetarians mean age year vegetarians mean age year depending nutritional status also repeat polymorphism ilrn gene performed polymerase chain reaction pcr agarose gel electrophoresis method results significant differences genotype allele distribution polymorphism nonvegetarians vegetarians respectively also significant associations qus parameters among genotype group study groups respectively statistically significant differences among normal osteopenia osteoporosis groups allele genotype distributions polymorphism respectively conclusions taken together results suggest repeat polymorphism ilrn gene may one useful genetic markers severity osteoporosis korean males nevertheless study yet preliminary studies using larger sample size needed
background aim assess variability spontaneous blink rate sbr without chin forehead support methods forty eight healthy non contact lens wearers aged years five minute video recordings made ambient lighting lux directing gaze distant target head height half subjects group seated resting chair head rest half group seated chin forehead slitlamp first blinks analysed detail results assessed five minutes blinks counted sbr blinks per min average per min initial blinks average momentary sbr values calculated inter blink intervals averaged blinks per minute group blinks per minute group significantly different statistically significant decrease sbr observed initial blinks group variability momentary sbr values assessed successive blinks coefficient variation cov values per cent respectively blinks conclusions averaged spontaneous blink rates short time periods five minutes suitable compare various experimental paradigms short periods used example one minute less could significant time related changes especially subject seated chin forehead support
background automatic analysis facial expressions evolving field finds several clinical applications one applications study facial bradykinesia parkinson disease major motor sign neurodegenerative illness facial bradykinesia consists reduction loss facial movements emotional facial expressions called hypomimia new method work propose automatic method studying facial expressions patients relying video based methods parkinsonian patients healthy control subjects asked show basic facial expressions upon request clinician imitation visual cue screen existing face tracker euclidean distance facial model neutral baseline computed order quantify changes facial expressivity tasks moreover automatic facial expressions recognition algorithm trained order study expressions differed standard expressions results results show control subjects reported average higher distances patients along tasks comparison existing methods confirms control subjects show larger movements posed imitated facial expressions moreover results demonstrate anger disgust two impaired expressions patients conclusions contactless video based systems important techniques analyzing facial expressions also rehabilitation particular speech therapy patients could get definite advantage real time feedback proper facial expressions movements perform elsevier rights reserved
background benefits addition carnitine diet cats control weight gain removal ovaries highlighted recently also used women menopause whether supplementation alters sexual hormones concern objectives objective study evaluate effect dietary supplementation carnitine estrogen progesterone testosterone cats following ovariohysterectomy methods conventional midline ovariohysterectomy performed dsh adult healthy female cats days surgery cats divided two groups randomly group single dose day carnitine added regular diet days cats group received carnitine diet blood samples taken cats prior surgery days post operatively serum levels estrogen progesterone testosterone measured using commercially available amh enzyme linked immunosorbent assay elisa results serum levels estrogen progesterone significantly decreased days surgery cats conclusions concluded dietary supplementation carnitine effect serum levels estrogen progesterone testosterone cats following ovariohysterectomy long term study recommended
background best predictors short medium term mortality cirrhotic patients receiving intensive care support unknown methods conducted meta analyses studies cirrhotics selection original articles response standardized questionnaire corresponding authors end points icu hospital month mortality icu survivors total pooled analyses including analyses restricted month mortality among icu survivors conducted considering variables including reason admission organ replacement therapy composite prognostic scores results icu hospital month mortality respectively forty eight patients underwent liver transplantation follow icu mortality lower patients admitted variceal bleeding baseline ppv high sofa longer predicted mortality months icu survivors twelve variables related infection predictors icu mortality including sirs ppv pneumonia ppv sepsis associated refractory oliguria ppv fungal infection ppv among therapeutics dopamine ppv dobutamine ppv epinephrine ppv mars ppv associated icu mortality without heterogeneity icu survivors eight markers liver renal failure predicted month mortality including child pugh stage ppv hepatorenal syndrome ppv conclusions prognosis cirrhotic patients admitted icu poor since minority undergo liver transplant prognostic performance general icu scores decreases time unlike child pugh meld scores even recorded context organ failure infection related parameters short term impact whereas liver renal failure sustained impact mortality
background consumption certain drugs cause urinary incontinence aim study determine frequency consumption drugs favour incontinence incidence polypharmacy incidence potentially dangerous drug drug interactions female patients suffering overactive bladder oab presented urogynaecological outpatient department methods undertook retrospective case series study data female patients attended urogynaecological outpatient department vienna general hospital vgh allgemeinen krankenhauses wien akh period evaluated patients suffered either dab mixed incontinence predominantly urge components among factors interested drugs taken longer periods time well general urogynaecological case histories parameters recorded age bmi menopausal status parity pelvic organ prolapse diappers criteria delirium infection urinary atrophic urethritis vaginitis pharmaceuticals psychological disorders especially depression excessive urine output restricted mobility stool impaction drug side effects drug drug interactions descriptive statistical analysis performed drugs checked help drug information system intranet particular interest consumption drugs could favour urinary incontinence adverse side effect addition frequency polypharmacy frequency potentially health threatening drug combinations registered results patients consumed least one drug could reinforce urinary incontinence frequency polypharmacy patients possibility health damaging interactions existed result consumed drugs conclusion frequencies consumption drugs favour urinary incontinence polypharmacy high among patients attend specialist outpatient department urinary incontinence emphasises importance complete drug history diagnostic work urinary incontinence
background costs treating eating disorders often considered high aims objective perform cost utility analysis estimate cost effectiveness treatment anorexia nervosa methods thirty nine patients entering treatment completed health related quality life hrqol questionnaire years start treatment direct hospital costs obtained quality adjusted life years qalys gained calculated cost utility assessed results patients baseline hrqol severely impaired follow mean hrqol improved statistically significantly cost per qaly gained euro best case scenario euro base case scenario euro euro discounted depending assumptions used analysis conclusions cost per qaly range many interventions provided specialized medical care within limits usually considered acceptable indicating treatment cost effective
background cryo japan pms study indicated cryoballoon ablation cryo abl lower acute success rate pulmonary vein isolation pvi right left inferior pvs ripv lipv respectively superior pvs study aimed determine orientation position inferior pvs related difficulty acute success pvi methods results investigated consecutive patients underwent cryo abl difficult defined requirement cooling applications touch ablation achieve pvi measured ventral angle vertical line direction trunk angle transverse plane enhanced images position defined difference levels bottom ripvs non coronary cusp aorta angle position independent factors difficult ripv isolation angle odds ratio confidence interval position position also related difficulty lipv isolation conclusions ripv ventral orientation may require difficult maneuvers advance ablation system towards low take inferior pvs may cause non coaxial configuration balloon catheters towards direction veins
background diagnosis cardiac involvement rheumatic disorders challenging due varying clinical presentation since clinical consequences range immediate treatment changes adverse long term outcome individual risk stratification great clinical interest primary aim evaluate prevalence cardiac involvement patients different rheumatic disorders using late gadolinium enhancement cardiac magnetic resonance imaging lge cmr addition sought investigate different rheumatic disorders would demonstrate different lge patterns methods two hundred ninety seven patients rheumatic disorders included underwent lge cmr work cardiac involvement defined presence lge myocardium patients divided five subgroups anca associated vasculitis non anca associated vasculitis connective tissue disorders arthritis sarcoidosis results mean ejection fraction overall population mean age yrs prevalence cardiac involvement five subgroups follows anca associated vasculitis group non anca associated vasculitis group group connective tissue disorders arthritis group sarcoid patients five subgroups demonstrated distinct pattern lge conclusion wide range prevalence cardiac involvement different rheumatic disorders different groups rheumatic disorders demonstrate different patterns lge condensed abstract primary aim study evaluate presence cardiac involvement patients different rheumatic disorders using lge cmr addition sought investigate different rheumatic disorders would reveal different lge patterns patients highest prevalence cardiac involvement found patients anca associated vasculitis whereas lowest prevalence demonstrated patients connective tissue disorders furthermore different groups rheumatic disorders demonstrate distinct patterns lge elsevier ireland ltd rights reserved
background early age retinoblastoma occurrence common eye malignancy childhood suggests perinatal factors may contribute etiology methods large multicenter study non familial retinoblastoma conducted structured interviews parents cases controls elicit information health perinatal period used unconditional logistic regression assess associations retinoblastoma parental fertility treatment birth control use year prior pregnancy maternal health conditions use prescription medications pregnancy whether mothers breastfed index child results bilateral retinoblastoma related maternal underweight body mass index prior pregnancy odds ratio confidence interval regards unilateral retinoblastoma observed negative association use condoms year prior pregnancy trend towards positive association maternal diabetes conclusions results study suggest role several maternal health reproductive factors given epidemiologic studies retinoblastoma results require replication studies utilize medical record review
background effects radiation skin particularly troublesome patients result impaired quality life inability perform activities daily living skin care radiation therapy needed prevent treat radiation dermatitis patient adherence prescribed skin care protocols paramount optimal outcome always monitored closely objectives focus study optimize patient adherence oncology nursing society putting evidence practice recommendations skin care radiation therapy methods multidimensional approach used enhance adherence skin care protocol outcomes measured included adherence patient satisfaction skin condition findings five interacting dimensions affect adherence health system socioeconomic therapy related patient related condition related factors self reported adherence washing moisturizing protocol treatment week treatment week high implementation skin care protocol introduced study led statistically significant decrease level skin toxicity
background efficacy safety direct acting antiviral agents daas evaluated cohort prospectively enrolled patients hepatitis virus hcv related mixed cryoglobulinaemia immune complex mediated vasculitis small medium vessels pathogenetic role hcv clearly established methods twenty two patients received daas clinical laboratory features recorded baseline every weeks end treatment eot weeks afterwards primary efficacy endpoints sustained virological response weeks therapy completion svr regression symptomatology clinical response cryoglobulin disappearance cryocrit reduction immunological response complete response defined occurrence three primary endpoints partial response defined occurrence svr without either immunological clinical response response defined missing achievement three endpoints results patients reached svr compared basal values mean cryocrit values significantly decreased eot svr significant reduction alanine transaminase parallel increase complement component levels also detected rheumatoid factor activity significantly reduced eot svr svr established patients patients one patient small lymphocytic lymphoma tumour progressed despite viral clearance mild adverse events recorded nine patients conclusions response rates induced use daas patients remarkably higher previously achieved pegylated interferon ribavirin without rituximab much longer follow desirable achieve useful information terms persistent viral clearance clinical response
background efficacy disease management programs improving outcome heart failure patients remains uncertain may vary across health systems study explores whether countrywide disease management program superior usual care reducing adverse health outcomes improving well among community dwelling adult patients moderate severe chronic heart failure universal access advanced health care services technologies methods multicenter open label trial patients recruited hospitalization heart failure exacerbation community randomly assigned either disease management usual care disease management delivered multi disciplinary teams included coordination care patient education monitoring disease symptoms patient adherence medication regimen titration drug therapy home tele monitoring body weight blood pressure heart rate patients assigned usual care treated primary care practitioners consultant cardiologists primary composite endpoint time elapsed till first hospital admission heart failure exacerbation death cause secondary endpoints included number hospital admissions health related quality life depression follow intention treat comparisons treatments adjusted baseline patient data study center results follow patients assigned disease management assigned usual care primary endpoint event median range time elapsed primary endpoint event end study years among patients assigned disease management years among patients assigned usual care adjusted hazard ratio confidence interval hospital admissions mostly unrelated heart failure patients assigned disease management better health related quality life lower depression score follow conclusions comprehensive disease management intervention superior usual care respect primary composite endpoint improved health related quality life depression disease centered approach may suffice make significant impact hospital admissions mortality patients chronic heart failure universal access health care
background existing literature suggests presence possible relationship high anger levels smoking behavior however available data highlighting possible differences moderate heavy smokers putative effect gender smoking behavior objectives aims current study assess relationship among anger depression anxiety smoking patterns taking account possible mediator role gender methods smokers nonsmokers volunteers recruited staff university messina italy final sample consisted smokers divided heavy smokers cigarettes per day moderate smokers cigarettes per day nonsmokers subjects assessed state trait anger expression inventory self rating depression scale self rating anxiety scale results anger depression anxiety measures group scored higher groups showed higher expected levels trait anger greater tendency control anger reactions access anger management techniques moderate consumption cigarettes cigarettes per day associated negative emotions showed higher expected levels state anger cigarettes consumption related gender specific anger features conclusions importance study highlighted importance anger smoking behavior related gender differences recognizing link among anger gender differences smoking behavior could improve knowledge future focused interventions smoking cessation
background expansion methadone maintenance treatment mountainous areas still limited little known health impacts drug users study aimed examine health related quality life hrqol health care access among patients engaging methadone maintenance treatment mmt tuyen quang mountainous province vietnam methods conducted cross sectional survey patients conveniently recruited two mmt clinics son duong tuyen quang euroqol dimensions levels visual analogue scale vas employed measure hrqol multivariate logistic tobit regressions used determine factors associated hrqol health care utilization results overall mean score index vas respectively utilized inpatient services used outpatient services highly educated suffering acute diseases using health service within last months associated decreased index individuals multiple substance abusers recently inpatient care likely lower vas older respondents taking medications impoverished clinic substance abusers individuals struggling anxiety depression usual daily activities likely use inpatient outpatient care conclusions summary observed good hrqol high prevalence anxiety depression low rates service utilization among mmt patients tuyen quang province improve outcomes mmt services mountainous areas necessary introduce personalized integrative services models counseling interventions multiple substance use
background explosion consumer electronics social media facilitating rise quantified self movement millions users tracking various aspects daily life using social media mobile technology wearable devices data mobile phones wearables social media facilitate better understanding health behaviors individuals time unprecedented increase childhood obesity rates worldwide cause grave concern due potential long term health consequences diabetes cardiovascular diseases childhood obesity highly prevalent qatar gulf region study examine feasibility capturing quantified self data social media wearables mobiles within weight lost camp overweight children qatar methods children years old parents used wide range technologies including wearable sensors actigraphy mobile social media whatsapp instagram collect data related physical activity food integrated physiological data gain insights health habits paper report acquired data visualization techniques following degrees quantified self methodology haddadi ichi results allows capturing insights behavioral patterns children serves mechanism reinforce education mothers via social media also identified human factors gender cultural acceptability aspects affect implementation technology beyond feasibility study furthermore technical challenges regarding visualization integration heterogeneous sparse data sets described paper conclusions proved feasibility using childhood obesity pilot study however order fully implement technology careful planning integration health professionals workflow needed
background gain function mutation jakvf frequently found philadelphia chromosome negative myeloproliferative neoplasm mpn patients however tumorigenic properties jakvf mostly characterized vivo vitro murine models due lack appropriate human cell lines methods using multipotent hematologic cell line established novel human cell line expresses jakvf upon tetracycline addition assessed cellular differentiation cells jakvf induced used microarrays analyze changes mrna expression caused jakvf results using human cell line demonstrated induction jakvf leads cytokine independent cell growth increased stat activation erythroid differentiation mimicking characteristics observed polycythemia vera making suitable vitro model studying disorder interestingly jakvf dependent erythroid cell differentiation blocked csf added culture suggesting csf pathway antagonizes jakvf induced erythroid cell differentiation microarray analysis identified several genes involved inflammasome activation aim ilb casp significantly regulated jakvf induced cells conclusions observed inflammasome activation following jakvf induction consistent recent report demonstrating involvement ilb myelofibrosis development jakvf model mouse results indicate cell line useful characterizing signaling pathways downstream jakvf allowing identification effector molecules contribute development mpn
background human chromosome mirna cluster cmc genes primate specific mirna cluster may biological significance genetic complexity primate despite previous reports individual cmc mirna expression cancer stem cells systematic studies cmc mirna expression biological functions lacking results cluster wide cmc mirna expression profiling microarray analysis showed wholesome cmc activation embryonic stem cells escs induced pluripotent stem cells ipscs however multipotent adipose derived mesenchymal stem cells mscs unipotent human white pre adipocyte cell line selected cmc mirnas expressed mirna copy number analysis also showed selective cmc expression cancer cells expression patterns highly similar mscs suggesting similar mirna regulatory mechanisms cells selective mirna expression also suggests complex transcriptional mechanism regulating cmc expression specific cellular pathological conditions bioinformatics analysis showed sixteen cmc mirnas share aagugc seed sequence members mir family known cellular reprogramming factors particular cmc aagugc mirnas nucleotides canonical seed position mir mirnas may play similar roles mir induced pluripotency biased arm selection cmc aagugc mirnas observed indicating targets species mirnas may biologically significant regulating stemness furthermore bioinformatics analysis putative targets cmc aagugc mirnas predicted significant involvement signaling pathways reprogramming many contribute promoting apoptosis indirect activation pro apoptotic proteins bak bax via suppression genes cell survival pathways enhancing caspase activation targeting inhibitors trail inducing apoptosis conclusions work demonstrated selective cmc expression mscs cancer cells mirna profiling bioinformatics analysis predicted cmc modulation apoptosis induced pluripotency tumorigenesis
background ichthyoses rare genetic disorders associated generalized scaling erythema epidermal barrier impairment pathogenesis basedtherapy largely lacking underlying molecular basis poorly understood objective sought characterize molecularly cutaneous inflammation correlation clinical barrier characteristics methods analyzed biopsy specimens genotyped patients ichthyosis congenital ichthyosiform erythroderma lamellar ichthyosis epidermolytic ichthyosis netherton syndrome using immunohistochemistry pcr compared specimens healthy control subjects patients atopic dermatitis patients psoriasis clinical measures included ichthyosis area severity index iasi integrates erythema iasi scaling iasi transepidermal water loss pruritus results ichthyosis samples showed increased epidermal hyperplasia increased thickness keratin expression tcell dendritic cell infiltrates increases general inflammatory innate beta interferon ifn gamma markers patients ichthyosis comparable patients psoriasis tnf alpha levels patients ichthyosis increased netherton syndrome much lower patientswith psoriasis withad expression cytokines similar seen control subjects striking induction related genes markers synergistically induced tnf alpha cxcl ccl ilg patients ichthyosis similar seen patients psoriasis iasi iasi scores strongly correlated tnf synergistic additive gene expression markers also significantly correlated transepidermal water loss suggesting link barrier defect inflammation patients ichthyosis conclusion data associate shared immune fingerprint major orphan forms ichthyosis raise possibility targeting strategies
background importance process evaluations examining interventions successful increasingly recognized process evaluations mainly studied implementation process quality implementation fidelity however adopting approach participatory organizational level occupational health interventions important aspects context participants perceptions missing objective systematically describe implementation process participatory organizational level occupational health intervention aimed reducing work stress increasing vitality two schools applying framework covers aspects intervention implementation well context participants perceptions methods program theory developed describing requirements successful implementation requirement operationalized making use framework covering initiation communication participation fidelity reach communication satisfaction management support targeting delivery exposure culture conditions readiness change perceptions requirements assessed quantitative qualitative data collected months baseline schools questionnaire interviews continuously logbooks results intervention consisted needs assessment phase phase implementing intervention activities needs assessment phase implemented successfully school school participation readiness change insufficient second phase several intervention activities implemented school whereas partly case school delivery schools however participants felt involved choice intervention activities targeting participation support resulting negative perception partial exposure intervention activities conditions culture events hindered implementation intervention activities schools conclusions framework helped understand implementation process successful therefore considered added value evaluation implementation processes participatory organizational level interventions foremost context mental models dimensions however less demanding methods detailed process evaluations need developed done know important process components study contributes knowledge base
background incidence rates irs factors associated injuries sport paralympic athletics track field comprehensively prospectively studied purpose determine injury irs characteristics injuries associated factors sport athletics london paralympic games study design cohort study level evidence methods total athletes competing sport athletics followed total day competition period paralympic games daily injury data obtained via databases custom built web based injury illness surveillance system web iiss maintained team medical personnel organizing committee database maintained medical providers medical stations operated london organising committee olympic paralympic games athlete impairment event discipline obtained via international paralympic committee athlete database irs injuries per athlete days impairment event discipline sex age examined results overall injuries per athlete days track disciplines ambulant athletes cerebral palsy experienced lower incidence injuries compared ambulant athletes impairment categories athletes seated throwing experienced higher incidence injuries compared athletes wheelchair racing track field disciplines majority injuries result time loss competition training ambulant athletes experienced greatest proportion injuries thigh injuries observed predominantly track athletes wheelchair seated athletes experienced greatest proportion injuries shoulder clavicle injuries observed predominantly field athletes conclusion first prospective cohort study examining injury irs associated factors sport athletics paralympic games injury patterns specific event discipline athlete impairment majority injuries occurred thigh ambulant athletes shoulder clavicle wheelchair seated athletes result time loss
background increased physical demands professional athletes predispose patient population unique set injuries typically seen general population systematic literature review investigates nature injury reporting orthopedic nonorthopedic conditions medical literature professional athletes national football league nfl major league baseball mlb national basketball association nba national hockey league nhl rigorous reporting sports injuries helps clinicians better understand disease mechanisms relevant specific sports hypothesis nature injury reporting differ within professional sport reflect anatomic emphasis sport methods electronic literature search publications addressing injuries medical conditions among professional athletes nfl mlb nba nhl conducted using pubmed medline scopus embase databases january retrieved publications categorized journal type medical type area focus results total publications met inclusion criteria higher number articles regarding nfl mlb compared nba nhl nfl significantly articles addressing nonorthopedic injuries medical issues found mlb nba nhl respectively nfl nhl relatively high percentage articles regarding concussions neurology mlb relatively high percentage articles dedicated vascular medicine proportion publications dedicated knee lower leg highest nfl nba dedicated shoulder elbow highest mlb dedicated hip pelvis highest nhl conclusions number type publications vary among professional sports leagues generally reflect nature sport played
background increasing use computers science allows scientific analyses large datasets increasing pace provided examples interactive demonstrations dundee science centre part women science festival present aspects computational science general public used low cost raspberry computers provide hands experience computer programming demonstrated application computers biology computer games used means introduce computers younger visitors success event evaluated voluntary feedback forms completed visitors conjunction self evaluation work builds original work bioinformatics education program barker bmc bioinform provides open source education materials bioinformatics work looks potential adapt similar materials public engagement events results appears least small sample visitors basic computational science conveyed people ages means interactive demonstrations children young five able successfully edit simple computer programs supervision many cases first experience computer programming feedback predominantly positive showing strong support improving computational science education also included suggestions improvement conclusions conclusions necessarily preliminary however feedback forms suggest methods generally well received among participants easy follow clear explanation easy demonstrators informative event held local science centre dundee demonstrates computer games programming activities suitable young children performed alongside specialised applied introduction computational science older visitors
background learning environment within school medicine influences medical students values professional development despite national requirements monitor learning environment mistreatment medical students persists methods designed program called smile eradicate student mistreatment learning environment vision enhance trainee faculty awareness ultimately eliminate medical student mistreatment provide description program early outcomes results program enhanced student awareness constitutes mistreatment report faculty members also aware formal processes procedures review incidents proposed model influences learning environment clinical workforce informs quality trainee education safety patient care institutional leadership culture play prominent role model integrated institutional response learning environment concerns offered strategy improve policy awareness reporting management student mistreatment concerns conclusions smile program developed enhance education awareness constitutes mistreatment provide multiple pathways student reporting clear responsibilities review adjudication enforcement program demonstrating several signs early success offered strategy schools adopt adapt recognized delicate balance preserving student anonymity informing specific actions taken providing students stakeholders clear evidence institutional response accountability remains key challenge multiple methods reporting advantageous eliciting information learning environment infringements routes types reporting enhanced understanding student perceptions specific contexts mistreatment occurs allowing targeted interventions common platform across healthcare professions report review concerns afforded opportunities deal interprofessional issues respectful trustworthy manner offer model learning environment influences leadership institutional culture helm way frame comprehensive perspective challenging complex concern
background natural history chronic hepatitisb chb infection divided different phases including immune tolerance immune clearance immune active inactive carrier reactivation despite utilizing high throughput data distinct immunological mechanisms phases insufficiently investigated objectives aim present study determine candidate disease associated genes significantly altered biological processes phase chb infection methods gene expression profiles chbpatients phases obtainedfromgene expression omnibus geo dataset gse analyzed bioinformatics tools several plugins cytoscape software used construct proteinprotein interaction ppi networks measure topological properties subsequently functional annotation signaling pathway enrichment carried using database annotation visualization integrated discovery david kyoto encyclopedia genes genomes kegg results deregulated genes identified patients respectively gene ontology kegg pathway analyses showed several immune response associated genes signaling pathways cytokine cytokine receptor interaction chemokine signaling pathway cell receptor signalling pathway upregulated phase downregulated phase lck encoding tyrosine kinase determined important hub gene constructed ppi networks furthermore otherimmuneresponse associated genes cxcr vcan myc stat found important hub genes clinical phases chb conclusions immune response related pathways found downregulated immune clearance phase inactive carrier phase chb respectively lck hub genemight help pathogenesis different phases chb serve therapeutic target treatment hepatitis virus
background objective epidemiological study evaluate effect length sunlight exposure interleukin levels depressive non depressive subjects methods cross sectional study subjects males mean age years living rural area south brazil chronobiological light parameters assessed using munich chronotype questionnaire sleep quality evaluated using pittsburgh sleep quality index depressive symptoms assessed beck depression inventory plasma levels inflammatory cytokines tumor necrosis factor interferon collected daytime measured results levels showed positive correlation light exposure negative correlation mid sleep phase work free days multiple linear regression analysis showed length light exposure independent factor predicting levels beta non depressed subjects exposure different intensity light affect levels however two depressive groups low high light exposure compared low light exposure group lower levels compared high light exposure group conclusions amount time participants exposed sunlight directly related levels additionally depressed subjects differ levels exposed light differing amounts time
background objective research develop caregiver reported clinical outcome assessment coa measure designed assess observable behaviors children ages years autism spectrum disorder asd supporting labeling claims treatment benefit methods development measure included review literature existing instruments conceptual disease model development concept elicitation focus groups item generation cognitive debriefing interviews results predominant characteristics behaviors asd identified literature instrument reviews included sociability communication deficits stereotypy inattention hyperactivity irritability anxiety familial impact instruments reviewed evidence content validity limited nonexistent predominant themes arose across major categories concept elicitation total concepts identified focus group feedback formed basis item development cognitive pre testing revisions items yielded final version daily diary containing items assessing observable behaviors characteristics asd children years old conclusions observable behaviors asd scale obas developed self administered caregiver reported measure containing predominant themes items scored one two point ordinal categorical response scales recall period item past hours research provides evidence obas content valid assessing treatment benefit found lacking instruments
background overexpression histone deacetylases hdacs observed many cancers inhibition specific hdacs emerged new target cancer therapy found hdac expression selectively reduced hdac inhibitor apicidin salivary mucoepidermoid carcinoma mec cells show hdac suppression potent antitumor effect mec cells methods histone deacetylases knocked using hdac sirnas cell proliferation quantified cell cycle progression apoptosis autophagy measured flow cytometry immunoblotting results histone deacetylases sirnas inhibited cell proliferation myc expression increased expression caused phase cell cycle arrest cells hdac silencing increased sub population annexin positive apoptotic cells cleaved caspase levels hdac silencing induced increase autophagic markers number acidic vesicular organelles lcb levels decrease levels hdac sirnas reduced activation erk hdac knockdown resulted growth inhibition phase cell cycle arrest induced apoptosis autophagy mec cells conclusions study indicates inhibition hdac might become novel effective therapeutic approach treating mec
background pituitary adenoma causing acromegaly typically resected transsphenoidal approach visualized operating microscope endoscope undertook systematic review meta analysis examining clinical efficacy endoscopic microsurgical approaches methods relevant studies using either endoscopic microscopic transsphenoidal approaches growth hormone pituitary adenomas identified february data extracted analyzed according predefined clinical end points results identified studies patients underwent endoscopic transsphenoidal resection patients underwent microsurgical transsphenoidal resection patients undergoing microsurgery less likely present hypothyroidism patients less likely macroadenomas patients adenomas cavernous sinus invasion patients lower mean tumor volume patients patients treated via endoscopic approach likely achieve remission noninvasive macroadenomas patients sinusitis patients intraoperative cerebrospinal fluid leak patients common patients treated endoscopically meningitis patients common patients undergoing microsurgical approach conclusions study shows clinical utility endoscopic approach demonstrates potential benefits including increased remission rates noninvasive macroadenomas lower rate meningitis
background postpartum period represents major transition lives many women time women increased risk emergence psychopathology including depression ptsd current study aimed better understand unique contributions clinically significant postpartum depression ptsd comorbid ptsd depression mother infant bonding observed maternal parenting behavior behavioral sensitivity negative affect positive affect months postpartum methods mothers oversampled history childhood maltreatment given parent study focus perinatal mental health women trauma histories infants participated month home visit dyads engaged interactional tasks varying level difficulties mothers also reported childhood abuse histories current depression ptsd symptoms bonding infant using standardized validated instruments results mothers clinically significant depression parenting impairment self report ant observed mothers clinically significant ptsd alone due interpersonal trauma occurred predominately childhood showed similar interactive behaviors healthy controls trauma exposed resilient postpartum psychopathology childhood maltreatment absence postpartum psychopathology infer parenting risk limitations findings limited small cell sizes per clinical group limiting power sample size sample demographics prohibited examination third variables might also impact parenting income education self report symptoms rather use psychiatric interviews conclusions findings show context child abuse history current ptsd clinically significant maternal depression salient factor infancy associated parenting impairment level analysis
background presence coronary artery calcification associated significant burden coronary artery disease along predictor increased adverse ischemic events diamondback coronary orbital atherectomy system oas novel device designed facilitate treatment calcified lesions study aimed evaluate cost effectiveness oas compared standard treatment methods decision tree model utilizing orbit clinical trial medicare data health system perspective constructed target population patients age coronary atherosclerosis due calcified coronary lesion inpatients outpatients combined time horizon two years costs lifetime mortality oas compared standard treatment use balloon angioplasty prepare stent placement site outcomes costs index event target vessel revascularization two years life years gained incremental cost effectiveness ratios icers results average oas projected cost less standard treatment inpatients standard treatment outpatients standard treatment overall projected mortality reduction implies life years gained compared standard treatment oas dominant inpatient setting icer per qaly outpatient setting icer per qaly overall icers accepted threshold highly cost effective interventions per qaly conclusions compared standard treatment oas likely cost effective projected cost saving inpatient setting summary decision tree health system perspective used evaluate cost effectiveness diamondback coronary orbital atherectomy system oas novel device designed facilitate treatment calcified lesions oas projected cost less standard treatment inpatients standard treatment outpatients standard treatment overall projected mortality reduction implies life years gained compared standard treatment oas dominant inpatient setting icer per qaly outpatient setting overall icer per qaly authors published elsevier inc open access article license http creativecommons org licenses
background prevalence comorbid knee pathology examined sports related anterior cruciate ligament acl injuries examined ice hockey players purpose compare concomitant bone bruising collateral ligament injuries intra articular injuries acl injuries suffered ice hockey versus sports study design cross sectional study level evidence methods total patients acl injuries sustained ice hockey identified prospective registry male contact mechanism injury moi thirteen cases controls sustained acl injuries ice hockey sports respectively included inclusion criteria cases controls male sex contact moi prior knee surgery magnetic resonance imaging mri within weeks injury surgery within months injury age body mass index bmi mri findings bone bruising medial lateral collateral ligament mcl lcl injuries arthroscopic findings meniscus tears chondral injuries compared cases versus controls using tests exact chi square tests results age years bmi differ cases controls cases less lateral bone bruising lateral femoral condyle lateral tibial plateau medial bone bruising medial femoral condyle medial tibial plateau compared controls cases less frequent lateral meniscus tears controls significant differences mcl lcl medial meniscus tears chondral injuries cases versus controls conclusion male ice hockey players acl injuries less lateral femoral condyle medial tibial plateau bone bruising compared sports injuries also fewer lateral meniscus tears trend toward fewer medial meniscus tears differences may reflect different mois ability dissipate energy contact acl injuries occur ice hockey versus sports
background prevalence depression young people increasing predominant morbidities juvenile depression include sleep disturbances persistent problems sleep wake rhythm shown influence treatment outcomes negatively severe mood dysregulation another condition includes depressive symptoms problems sleep wake rhythm patients severe mood dysregulation show symptoms depression reduced need sleep disturbances circadian functioning negatively affect disorder specific symptoms daytime functioning one approach treating depression problems sleep wake rhythm use light therapy light therapy standard therapy ameliorating symptoms seasonal affective disorder depression adults yet investigated children adolescents trial effects weeks morning bright light therapy juvenile depression severe mood dysregulation evaluated methods design total patients depression aged years cases presenting additional symptoms affective dysregulation included trial morning bright light therapy implemented weeks sessions minutes either active light lux inactive light lux comprehensive test battery conducted treatment follow weeks later assess depression severity sleep attention parameters melatonin levels measured assessing dim light melatonin onset discussion pilot study use morning bright light therapy juvenile depression severe mood dysregulation shall evaluated discussed
background prevention severe hypoglycaemia based art accurately anticipating occurrence aim study analyse effect feedback procedure glycaemic state children type diabetes well associated symptoms estimated bgl method days participants performed scheduled capillary blood tests estimate self analysis whenever thought changes bgl results total trials analysed mean estimates corresponded hypoglycaemia states areas clinically dangerous consequences accurate bgl reached levels children reported symptoms random made mistakes linking bgl demanded opportunity feedback believing state hypoglycaemia hyperglycaemia conclusions bgl highly variable certain glycaemic profiles peaked greater average hypoglycaemia children usual daily surroundings present profile reliable signs indicative bgl tendency underestimate values glycaemia hyperglycaemic levels confirmed
background proteasome catalyzes degradation many mis folded proteins otherwise cytotoxic interest discovery proteasome agonists previous efforts disappointing methods cleavage small fluorogenic peptides used routinely assay screen proteasome modulators developed follow assays employ physiologically relevant substrates results demonstrate efficacy workflow nih clinical collection ncc screened many compounds stimulated proteasome mediated proteolysis pro fluorogenic peptide substrates failed evince activity assays larger peptide protein substrates also show two molecules claimed previously proteasome agonists oleuropein betulinic acid indeed accelerate hydrolysis fluorogenic substrate effect turnover mis folded protein vitro cellulo however two small molecules ncc stimulate proteasome mediated turnover mis folded protein living cells fold conclusion assays monitor proteasome mediated degradation larger peptides proteinscan distinguish bona fide agonists compounds able stimulate cleavage short non physiologically relevant peptides general significance suite assays established allows discovery bona fide proteasome agonists useful tools cell culture experiments serve scaffolds generate potent stimulators elsevier rights reserved
background relationship symptoms autism spectrum disorder asd generalised anxiety disorder gad complex sometimes confounding however exploration relationship significant potential assist treatment avoidance gad identifying asd related behaviours targets intervention anxious children well preventative treatments could implemented daily routines children become anxious understanding relationship association parent ratings sons asd symptoms gad symptoms investigated two samples boys high functioning asd methods parents sample pre adolescent age adolescent males age completed social responsiveness scale srs gad subscale child adolescent symptom inventory casi gad sons results pre adolescents significantly higher srs scale scores adolescents pre adolescents high levels tension social situations associated times greater likelihood gad adolescents experiencing difficulty changes routine associated fold increase risk gad conclusions addition focussing upon gad preventative treatment options aimed reducing gad risk might profitably recognise focus upon two aspects asd different across two age groups significantly associated gad severity prevalence study elsevier ltd rights reserved
background rhinovirus first identified produce high symptom burdens children asthmatics however primary target host cell airways remains unknown primary hypotheses target ciliated airway epithelial cells aecs cell specificity determined restricted high expression known cell entry factor cadherin related family member cdhr methods infection differentiated human bronchial epithelial cell hbec cultures assessed using immunofluorescent time lapse epifluorescent imaging morphology infected differentiated aecs assessed immunohistochemistry results produced scattered pattern infection infected cells shed epithelium percentage cells infected varied depending cell culture conditions infected cells increased staining markers ciliated cells acetylated alpha tubulin aat markers goblet cells wheat germ agglutinin mucac cdhr expression increased ciliated epithelial cells epithelial cells infection caused reduction ciliated cells expressing cdhr differentiation aecs cdhr expression progressively increased correlated binding replication conclusions replicate ciliated aecs vitro leading infected cell shedding cdhr expression positively correlates binding replication largely confined ciliated aecs data imply factors regulating differentiation cdhr production may important determinants illness severity
background risk benefit antithrombotic treatment att established patients dialysis objective determine influence att risk hemorrhage patients hemodialysis methods included patients began dialysis determined rates fatal bleeding bleeding leading hospitalization transfusion results two hundred twenty one patients included follow period months hemorrhages patients fatal bleedings annual incidence patients presenting hemorrhagia bleeding occurred treated aspirin acenocumarol clopidogrel aspirin clopidogrel anticoagulants antiplatelets low molecular weight heparin without att multivariate analysis masculine gender hazard ratio confidence interval treatment dicumarins treatment clopidogrel treatment low molecular weight heparin independent predictors bleeding conclusions att increases risk bleeding patients hemodialysis incidence hemorrhage varies type antithrombotics used
background skin extremely preterm infants underdeveloped poor barrier function skin maintenance interventions initiated neonatal intensive care unit nicu immediate lifelong implications potential infection allergen sensitization altered aesthetic outcomes considered addition high level medical needs extremely preterm infants demand skin level medical interventions often result unintended skin harm purpose describe use harm prevention consequence centered approach skin care facilitates safer practice extremely premature infants method neonatal pediatric advanced practice registered nurses aprn came together monthly meetings review evidence around best skin care practices extremely preterm infants emphasis reduction skin harm findings focused population interest clinical implementation strategies findings skin care extremely preterm infants remains overlooked current literature however clinical practice pearls extracted applied manner promotes safer skin care practices nicu implications practice gentle adhesives silicone tapes hydrogel backed electrodes help reduce medical adhesive related skin injuries diaper wipes appropriate use among extremely preterm infants many ingredients may contain potential allergens skin cleansers neutral skin prophylactic use petrolatum based emollients avoided implications research exploration understanding skin care practices examine issues true risk versus hypothetical risk harm
background success facilitator based model advance care planning acp lacrosse wisconsin inspired health systems aim widespread documentation advance directives limited resources impair efforts replicate model one promising strategy development interactive internet based tools might increase access individualized acp minimal cost however widespread adoption implementation internet based acp efforts yet described objective describe early experiences building systematic population based acp initiative focused health system wide deployment internet based tool adjunct facilitator based model methods sponsorship healthcare system population health leadership engaged diverse group clinical stakeholders champions design internet based acp tool facilitate local practice change describe simultaneously began train clinicians acp conversations engage patients health system employees thinking acp redesign clinic workflows accommodate acp discussions integrate internet based tool electronic medical record emr results months project engaged two subspecialty clinics systematic acp process began work large primary care practice large medicare accountable care organization risk population overall people registered internet site completed acps conclusion learned changing culture systems promote acp requires comprehensive vision simultaneous interconnected strategies targeting patient education clinician training emr documentation community awareness
background swallowing quality life questionnaire swal qol considered gold standard assessing health related qol oropharyngeal dysphagia dutch translation dswal qol adjusted version adswal qol validated using classical test theory ctt however scales tested rasch measurement model required establish structural validity objectivity total scale subscale scores thus purpose study examine psychometric properties scales using item analysis according rasch model methods item analysis rasch model performed using rumm software previously collected data validation study patients assessment included evaluations overall model fit reliability unidimensionality threshold ordering individual item person fits differential item functioning dif local item dependency lid targeting results analysis could establish psychometric properties either scales subscales fit rasch model multidimensionality disordered thresholds dif lid found reliability power fit high total scales psi low subscales psi targeting persons items suboptimal main source misfit disordered thresholds total scales subscales based results analysis adjustments improve scales implemented follows disordered thresholds rescaled misfit items removed items split dif however multidimensionality lid could resolved reliability power fit remained low subscales conclusions study represents first analyses dswal qol adswal qol rasch model relying dswal qol adswal qol total subscale scores make conclusions regarding dysphagia related hrqol treated caution structural validity objectivity scales established larger well targeted sample recommended derive definitive conclusions items scales solutions psychometric weaknesses suggested model practical implications discussed
background synovial membrane lines luminal side joint capsule synovial joints maintains joint homeostasis plays crucial role equine joint pathology trauma inflammation induced joint synovial membrane influences progression joint damage equine synovial membrane research hampered lack markers fibroblast like synoviocytes fls distinguish fls fibroblast like cells musculoskeletal connective tissues aim study identify potential fls markers equine synovial membrane using microarray compare gene expression equine synovial membrane joint capsule metacarpophalangeal joints results microarray analysis tissues horses resulted regulated genes synovial membrane compared joint capsule pathway analysis resulted candidate genes genes selected confirmation genes potentially expressed fibroblast like synoviocytes four genes foxo pxk pycard samdl confirmed horses qpcr differentially expressed synovial membrane compared joint capsule conclusions conclusion foxo pxk pycard samdl confirmed differentially expressed synovial membrane compared joint capsule four genes potential markers fibroblast like synoviocytes synovial membrane genes overexpressed synovial membrane compared joint capsule genes could shed light synovial membrane physiology role joint disease
background title family planning program provides affordable access range sexual reproductive health services priority low income people disproportionate burden unintended pregnancy breast cervical cancer sexually transmitted diseases among minority groups teens young adults underscore need affordable access services however increased access sexual reproductive health services resulting affordable care act aca create questions regarding continued need program methods study conducted assess clients perceptions title funded family planning clinics preferences clinics range sexual reproductive health services anonymous self administered paper pencil survey administered clients received services one eight title funded family planning clinics northeast ohio results majority participants stated positive perceptions title funded clinics always title funded clinic birth control std hiv testing pregnancy testing title funded clinic regular source health care females likely males prefer title clinic birth control physical exams pregnancy testing health information teens age preferred use title clinic std hiv testing physical exams pregnancy testing health information conclusions findings indicate title funded family planning clinics successfully reached populations need sexual reproductive health services suggest facilities help play important role reducing disparities even full implementation affordable care act however research needed fully quantify need value title funded family planning clinics relation changing health care environment
background transtheoretical model ttm widely used promote healthy behaviors different groups however questionnaire yet developed evaluate health behaviors medical practitioners often consider individuals cancer high risk developing cancer purpose aim study construct validate health behavior stages change questionnaire hbscq based ttm health recommendations related risk factors protect cancer methods content validity conducted two phases qualitative quantitative item difficulty index item discrimination index discrimination coefficient obtained based classical test theory finally cronbach alpha used results measure concordance showed scores considered adequate excellent item discrimination index obtained rating excellent suggested preservation items discrimination coefficient scores global internal consistency hbscq hbscq specification groups internal consistency sample men sample women conclusion implications practice hbscq represents proposal fast simple innovative screening test aims identify persons may benefit interventions promote health behaviors delimited stage change
background trend increasing numbers patients type diabetes emphasizes need active screening high risk individuals intensive lifestyle modification lsm methods design community based korean diabetes prevention study kdps randomized controlled clinical trial prevent type diabetes intensive lsm using web based program two public healthcare centers korea involved subjects recruited months followed months participants allocated randomly intensive lsm individual sessions weeks usual care control group major goals kdps lifestyle intervention program minimum loss initial body weight months maintenance weight loss increased physical activity min week moderate intensity activity balanced healthy eating quitting smoking alcohol stress management web based program includes education contents video files visit schedules inter communicable keeping track sites primary outcomes diagnoses newly developed diabetes oral glucose tolerance test hemoglobin level determination cardiovascular risk factor assessment scheduled months discussion active screening high risk individuals effective lsm program essential prerequisite successful diabetes prevention hope kdps program reduce incidence newly developed type diabetes implemented throughout country merging community based public healthcare resources web based system
background ultimate ambient intelligent care room contains numerous sensors devices monitor patient sense adjust environment support staff sensor based approach results large amount data processed current future applications task management alerting systems today nurses responsible coordinating applications supplied information reduces added value slows adoption rate aim presented research design pervasive scalable framework able optimize continuous care processes intelligently reasoning large amount heterogeneous care data methods developed ontology based care platform ocareplatform consists modular components perform specific reasoning task consequently easily replicated distributed complex reasoning achieved combining results different components ensure components receive information interest time able dynamically generate register filter rules semantic communication bus scb scb semantically filters heterogeneous care data according registered rules using continuous care ontology scb distributed cache employed ensure scalability results prototype implementation presented consisting new generation nurse call system supported localization home automation component amount data filtered performance scb evaluated testing prototype living lab delay introduced processing filter rules negligible fewer rules registered conclusions ocareplatform allows disseminating relevant care data different applications additionally supports composing complex applications set smaller independent components way platform significantly reduces amount information needs processed nurses delay resulting processing filter rules linear amount rules distributed deployment scb using cache allows improvement performance results
background theoretically specific pragmatic functions intentional communication differentially associated language use children autism spectrum disorder asd primary purpose meta analysis compare relation declarative imperative intentional communication acts icas respectively language skills also examined five possible moderators separate associations difference associations metric used quantify icas expressive versus receptive language longitudinal concurrent correlations within study interobserver reliability rating pragmatic function icas risk correlated measurement error method included studies provided least zero order correlation concurrent longitudinal language measures declarative imperative ica participants children asd aged years younger results twenty three studies included declarative icas significantly associated language weighted mean imperative icas significantly associated language moderator effects detected conclusions association declarative icas language implications early treatment asd related language deficits failure find significant association imperative icas language could due low statistical power publication bias research imperative icas needed elsevier ltd rights reserved
background estimated million surfers worldwide million recreational surfers australia recreational activity sport surfing grown dramatically since scientific research poorly mirrored comparison mainstream sports purpose identify incidence severity location type mechanism acute injuries recreational competitive surfers month period study design descriptive epidemiology study methods online survey using open source survey application utilized survey consisted primary sections section included demographic information participation levels age height weight hours surfed competitive level section incorporated injury type mechanism severity injury management results total participants males competitive surfers included data analysis total acute injuries classified major providing incidence proportion acute injuries per year incidence rate calculated major injuries per hours surfing shoulder ankle head face regions highest frequencies acute injury representing respectively injuries predominantly muscular joint skin origin representing respectively skin injuries primarily result direct trauma joint muscular injuries mainly result maneuvers performed repetitive actions key risk factors increased incidence sustaining acute injury included competitive status hours surfed hours week ability perform aerial maneuvers incidence proportion surfers completing aerial maneuvers calculated major injuries per year highest incidence proportion irrespective competitive status conclusion largest surfing specific survey included recreational competitive surfers conducted australia date shoulder ankle head face identified key regions acute injuries occur surfers research may aid reducing occurrence injury musculoskeletal screening key injury prone regions use sport specific strength training conditioning
background recent swell activity health research funding organizations science journal editors increase uptake sex gender considerations study design conduct reporting order ensure research results apply everyone however examination implementation research literature reveals attention sex gender yet infiltrated research methods field discussion rationale routinely considering sex gender implementation research multifold sex gender important decision making communication stakeholder engagement preferences uptake interventions gender roles gender identity gender relations institutionalized gender influence way implementation strategy works circumstances emerging evidence programme theories may operate differently within across sexes genders intersectional characteristics various circumstances furthermore without proper study implementation strategies may inadvertently exploit ignore rather transform thinking sex gender related factors techniques described measuring analyzing sex gender implementation research using quantitative qualitative methods summary present paper describes application methods integrating sex gender implementation research consistently asking critical questions sex gender likely lead discovery positive outcomes well unintended consequences result potential strengthen practice science implementation improve health outcomes reduce gender inequities
background debate older patients idiopathic pulmonary fibrosis ipf worse prognosis evaluated whether age affects survival patients ipf methods korean interstitial lung disease ild research group conducted national survey evaluate clinical physiological radiological survival characteristics patients ipf total patients ipf stratified three groups according age years results year observed survival rates total population respectively year relative survival rates patients respectively observed survival rate group years age significantly lower groups contrast significant difference relative survival rate detected among three age groups compared patients less years age patients years age increased risk worse relative survival hazard ratio confidence interval conclusions prognosis patients years age ipf different patients less years age using relative survival rate age may affect survival patients ipf
background increasing need evidence based efficiency providing growing amount cancer care one example quality gap use multiple fraction palliative radiation patients advanced cancer uncomplicated bone metastases evidence suggests similar pain outcomes treatment regimens lower burden treatments methods first phase quality improvement work used rand ucla appropriateness methodology understand radiation oncologists one academic medical center rate appropriateness different treatment regimens painful uncomplicated bone metastases compared radiation oncologist appropriateness ratings radiation treatments radiation therapy provided oncologists patients painful bone metastases july june results appropriateness ratings showed single fraction treatment low burden treatment consistently considered appropriate option treat variety uncomplicated bone metastases use fractions consistently rated inappropriate regardless factors eighty one patients receiving radiation therapy painful bone metastases study period available medical record chart abstraction almost one third metastases considered complicated concern spinal cord compression history prior irradiation associated pathological fracture among uncomplicated bone metastases treated stereotactic body radiation treatment sbrt among uncomplicated bone metastases treated conformal radiation one treated single fraction treatment treated greater fractions conclusions treatment study site demonstrates room improvement providing low burden radiation oncology treatments patients painful bone metastases choosing radiation treatment schedule patients advanced cancer painful bone metastases requires consideration many medical patient centered factors experience suggests take existence guidelines change practice area
background evidence inverse association endogenous testosterone blood pressure furthermore low plasma testosterone associated increased risk major cardiovascular events middle aged hypertensive men central aortic blood pressures determine left ventricular hypertrophy predict cardiovascular mortality aim present study assess relationship total testosterone central haemodynamics left ventricular mass hypertensive men methods investigated non diabetic middle aged hypertensive men age matched normotensive males participants subject measurement aortic systolic aosbp pulse pressure aopp pulse wave analysis using sphygmocor device wave reflections assessed measurement heart rate corrected augmentation index aix echocardiography performed individuals left ventricular mass lvm calculated using devereux formula plasma measured enzyme immunoassay results hypertensive men univariate analysis showed inverse significant correlation aosbp aopp aix lvm multivariate regression analysis demonstrated independent inverse association aopp aix lvm adjustment age bmi smoking total cholesterol triglycerides fasting glucose mean arterial pressure antihypertensive treatment statin use independent associations retained even inclusion normotensive subjects analysis conclusions hypertensive men independently inversely associated central pulse pressure wave reflections left ventricular mass considering adverse prognostic role central blood pressures hypertrophy cardiovascular outcomes hypertensive patients present findings might explain part increased cardiovascular risk associated low testosterone whether measurement central haemodynamics may improve risk stratification hypertensive men low testosterone warrants investigation elsevier ireland ltd rights reserved
background increasing evidence pathological overeating underlying forms obesity compulsive nature therefore contains elements addictive disorder however direct physiological evidence linking obesity synaptic plasticity akin occurring addiction lacking sought establish whether propensity diet induced obesity dio associated addictive like behavior well synaptic impairments nucleus accumbens core considered hallmarks addiction methods sprague dawley rats allowed free access palatable diet weeks separated weight gain dio prone dio resistant subgroups access palatable food restricted daily operant selfadministration sessions using fixed ratio progressive ratio schedules subsequently nucleus accumbens brain slices prepared tested changes ratio alpha amino hydroxy methyl isoxazole propionic acid ampa methyl aspartate currents ability exhibit long term depression results found propensity develop dio linked deficits ability induce long term depression nucleus accumbens well increased potentiation synapses measured ampa methyl daspartate currents consistent impairments observed addictive like behavior dio prone rats including heightened motivation palatable food excessive intake increased food seeking food unavailable conclusions results show overlap propensity dio synaptic changes associated facets addictive behavior supporting partial coincident neurological underpinnings compulsive overeating drug addiction
background still much know differences sports injuries young male female athletes factors may increase risk injuries regard purpose describe compare differences males females pediatric sports related injuries study design cross sectional study level evidence methods retrospective chart review performed using random sampling medical records children aged years seen years sports medicine clinic large academic pediatric hospital information collected analyzed age sex height weight injury type overuse acute traumatic location injury sports involvement results overall female athletes higher percentage overuse injuries compared traumatic injuries opposite seen male athletes respectively looking specific areas injury female athletes sustained injuries lower extremity spine compared male athletes respectively male patients greater percentage injuries upper extremity compared female patients type hip pelvis injuries differed greatly sex females sustaining overuse soft tissue injuries versus males suffered injuries tended traumatic bony nature males likely females participate team contact collision sports percentage females patellofemoral knee pain approximately times greater males respectively males twice likely females diagnosed osteochondritis dissecans respectively fractures respectively percentage males females sustained anterior cruciate ligament injury almost equal respectively conclusion sports injuries young males females differed injury type diagnosis body area results may related referral patterns unique division hospital including high number female dancers investigation required better understand injury risk pediatric male female athletes
background year prospective cohort study aimed compare changes clinical symptoms functional disability patients coexisting patellofemoral tibiofemoral osteoarthritis isolated tfoa methods seventy two patients medial knee enrolled knee pain functional disability assessed baseline year follow using japanese knee osteoarthritis measure jkom visual analog scale vas performed two way analysis covariance clinical outcome variables examine time baseline follow group coexisting pfoa isolated tfoa time group interaction effects furthermore conducted post hoc exploratory analysis address possibility dividing patients according location pfoa isolated lateral isolated medial mixed bilateral may identify distinct subgroup different changes clinical outcomes year follow results detected group effects scores jkom pain subscale vas adjusted age sex body mass index patients coexisting pfoa stable moderate level knee pain functional disability throughout year significantly worse isolated tfoa post hoc subgroup analysis demonstrated change knee pain likely varied location pfoa patients isolated lateral pfoa mild moderate level knee pain vas scores likely improve whereas mixed pfoa exhibited stable worsening moderate severe knee pain conclusions although detect differences changes clinical symptoms functional disability patients coexisting pfoa isolated tfoa findings indicate patients coexisting pfoa worse clinical symptoms functional disability isolated tfoa results exploratory analysis suggested patients coexisting pfoa might heterogeneous clinical outcomes presence mixed pfoa might indicator severe clinical knee
background article reports evaluation psychometric properties clinically important difference cid threshold ucsd performance based skills assessment upsa major depressive disorder mdd using data large scale study effects vortioxetine cognitive functioning functional capacity mdd patients methods adults moderate severe recurrent mdd self reported cognitive dysfunction randomized weeks double blind treatment vortioxetine flexible duloxetine placebo pearson correlation coefficients calculated upsa composite score demographic disease characteristics baseline examine construct validity two methods distribution based anchor based used establish cid threshold results total patients randomized comprised full analysis set entire sample mean upsa composite scores baseline week mean change hypothesized baseline upsa composite score correlated cognitive functioning digit symbol substitution test workplace productivity work limitations questionnaire depressive symptoms montgomery asberg depression rating scale subjective cognitive dysfunction perceived deficits questionnaire limitations two versions upsa used inclusion exclusion criteria based upsa conclusions results support construct validity upsa assessing functional capacity independent mood symptoms estimated cid changes upsa scores quite consistent points based distribution based anchor based methods respectively
background pilot study focused feasibility potential effectiveness protocol based narrative exposure therapy net integrated standard inpatient program treat patients comorbid borderline personality disorder bpd posttraumatic stress disorder ptsd methods eleven patients male female without previous stabilization periods absence intentional self injury received net ten week inpatient program patients assessed post treatment month follow results drop rates treatment low completing net furthermore acceptance net high one patient rejecting treatment program safe lead aggravations symptom severity either post treatment month follow additionally rate self harming behaviors throughout treatment phase low fact treatment associated positive effects ptsd bpd symptom severity well secondary outcome measures including depression dissociation quality life conclusions present study found net feasible safe inpatient setting treating highly burdened patients bpd ptsd also evidence potential effectiveness net highly burdened population
background review focuses treatment emergent mania hypomania tem associated repetitive transcranial magnetic stimulation rtms methods english language studies involving possible rtms induced mania hypomania published retrieved medline search using search terms mania hypomania mixed affective state treatment emergent repetitive transcranial magnetic stimulation rtms fifteen case series controlled studies describing tem associated rtms treatment published involving individuals whomwere diagnosed either bipolar disorder major depressive disorder results rtms shown possibly induce manic hypomanic episodes patients depression sometimes also taking antidepressants high frequency low frequency rtms different stimulus parameters may associated tem males females conclusions given findings highly recommended patients bipolar disorder experiencing depressive episode prescribed mood stabilizer patients diagnosed major depressive disorder reevaluated consider possibility might bipolar disorder rtms treatment initiated tem occurs discontinuation rtms considered continuing mood stabilizing medications research needed concerning underlying neurobiological mechanisms epidemiologic characteristics tem associated rtms
background study aimed assess association single nucleotide polymorphisms snps six genes irf tmema ikzf ormdl gsdmb zpbp systemic lupus erythematosus sle chinese han population sample methods carried case control study patients sle healthy controls without autoimmune disease cancer dna genetic analysis isolated blood subjects using standard phenol chloroform method tagsnps identified using genotype data panel han chinese beijing hapmap project selected using haploview program genotyping assay conducted using sequenom massarray iplex gold platform frequencies alleles genotypes calculated analyzed association studies haplotype analysis also performed results genotypic frequencies significantly different sle patients healthy controls compared common homozygous genotype genotypes genotypes observed significantly reduce risk sle haplotype analysis tmema polymorphisms showed cgta haplotype frequency significantly low sle patients conclusion findings identified three novel associations snps located tmema gene associated sle susceptibility chinese han population
background study aimed examine associations age presence complications glycemic control northwest iran methods total people diabetes years old caring record diabetes clinics two northwestern provinces iran recruited cross sectional study general information including demographic socioeconomic status lifestyle factors collected trained interviewers clinical information retrieved clinic record univariate multivariate logistic regression performed assess predictors diabetes outcome interest well clarify role age relation outcomes results compared age group years disease record times likely complications oradj conclusion although prevalence complications higher among older diabetic patients better glycemic control influential factors variably associated two diabetes related outcomes therefore comprehensive risk profiles assessment needed glycemic control
background study aims establish adult patients major depressive disorder mdd childhood attention deficit hyperactivity disorder adhd symptoms would frequently within bipolar spectrum depressed patients without childhood adhd methods study carried outpatients recruited psychiatrists private practice participants included final sample clinicians filled questionnaires current depressive symptoms patients lifetime bipolar symptoms global assessment functioning parental history major depression bipolar disorder patients assessed current level anxiety depressive symptoms antecedents childhood adhd symptoms results depressed adults significant childhood adhd symptoms specific pattern major depressive episode compared depressed patients without symptoms subjects childhood adhd symptoms likely report lifetime symptoms mania hypomania parent type bipolar disorder developmental trajectories familial risk lifetime bipolar symptoms showed parental bipolar disorder influenced lifetime bipolar symptoms direct pathway indirect pathway involving childhood adhd symptoms childhood adhd number depressive symptoms made direct contributions lifetime bipolar symptoms
background study examines socioeconomic inequality children health factors moderate inequality socioeconomic measures include household wealth maternal education urban rural area residence moderating factors include reproductive behavior access health care time economic development health expenditures foreign aid methods data taken demographic health surveys conducted african countries results birth spacing skilled birth attendants economic development greater per capita health expenditures benefit children disadvantaged mothers wealthy benefit services skilled birth attendant higher per capita expenditure health conclusion health behavior policy changeswould reduce social inequality wealthy benefit poor provision health services
background three successive editions international classification headache disorders multiple guideline papers headache care described evidence based diagnosis treatment headache disorders remains unknown however extent improved diagnosis management headache aim study also analysed differences three social groups russia methods studied students females males mean age age range workers females males mean age age range blood donors females males mean age age range conducted semi structured validated face face professional interview data prevalence associated factors previously published section interview focused previous diagnosis treatment topic paper results participants headache russia consulted headache students consulted frequently workers blood donors less often patients ichd beta diagnosis migraine ichd beta diagnosis tension type headache tth previously correctly diagnosed triptans used migraine patients migraine patients tth patients received prophylactic treatment conclusion despite existing guidelines diagnosis treatment remain poor russia according literature slightly better europe america dissemination existing knowledge higher priority future
background mounting genetic investigations established ilb ilr gene single nucleotide polymorphisms significant associations autoimmune diseases including inflammatory bowel disease psoriasis ankylosing spondylitis pathway plays pivotal role etiopathogenesis multiple sclerosis suggested studies patients animal models methods case control study patients healthy subjects genotyped polymorphisms ilb ilr genes using real time pcr allelic discrimination approach additionally quantitative analysis mrna expression ilb peripheral blood mononuclear cells patients controls conducted real time pcr using taqman gene expression assay results single nucleotide polymorphism snp ilb gene showed association susceptibility genotype variation frequent patients mrna expression ilb upregulated patients expression ilb mrna patients collectively genotype snp correlated negatively onset age patients conclusions genotype snp ilb gene plays role etiopathogenesis
background tinnitus associated depression anxiety disorders severely adversely affecting quality life functional health status people dearth clinical psychologists embedded audiology services cessation training hearing therapists left audiologists meet psychological needs many patients tinnitus however universally standardized training manualized intervention specifically audiologists across whole public healthcare system similar systems elsewhere across world objectives primary aim scoping review catalog components psychological therapies people tinnitus used tested psychologists might inform development standardized audiologist delivered psychological intervention secondary aims article identify types psychological therapy people tinnitus reported tested clinical trial well job roles clinicians delivered psychological therapy people tinnitus literature design authors searched cochrane ear nose throat disorders group trials register cochrane central register controlled trials pubmed embase cinahl lilacs koreamed indmed pakmedinet cab abstracts web science biosis previews isrctn clinicaltrials gov trp google scholar addition authors searched gray literature including conference abstracts dissertations editorials records excluded basis controls used outcomes reached timing setting study design except reviews search results records included psychological therapy intervention reported address adults years tinnitus related distress restrictive criteria placed upon term tinnitus records excluded intervention included biofeedback habituation hypnosis relaxation necessary parts treatment results total records retrieved retained twenty five themes components included within psychological therapy identified including tinnitus education psychoeducation evaluation treatment rationale treatment planning problem solving behavioral intervention thought identification thought challenging worry time emotions social comparison interpersonal skills self concept lifestyle advice acceptance defusion mindfulness attention relaxation sleep sound enrichment comorbidity treatment reflection relapse prevention common therapeutic skills frequently reported psychological therapies cognitive behavioral therapy tinnitus education internet delivered cognitive behavioral therapy records reported audiologist delivered psychological therapies context empirical trial role clearly delineated clinicians conclusions scoping review methodology attempt appraise quality evidence synthesize included records research therefore determine relative importance different components psychological therapies perspective patient clinician
background determine whether heavily drinking alcohol dependent workers higher risk occupational injury analyzed nationally representative cohort people enrolled national longitudinal survey youth since methods analysis restricted respondents annual interview age employed months interview studied occupational injuries excluding sprains strains reported within months interview cross sectional analysis prospective analysis results among current drinkers significant two fold increases odds injury one episodes heavy drinking reduced odds ratio confidence interval cross sectional analysis prospective analysis adjustment confounding dose response relationship frequency heavy drinking found alcohol dependent respondents higher risk injury cross sectional prospective analyses adjustment confounding conclusions young workers common occupational injuries excluding sprains strains may strongly associated alcohol dependence confounding risk factors may explain much association heavy drinker occupational injuries population
background extract information properties infectious disease data including hidden relationships could considered blood leukocyte data explored elucidate whether hidden information uncovered could forecast mortality methods three sets individuals investigated blood leukocyte profiles microbial tests conducted cross sectional analyses performed admission bacteriological tests completed two groups hospital patients randomly selected different time periods met septic criteria confirmed infection least three systemic inflammatory response syndrome sirs criteria lacked chronic conditions study study similar group tested days iii non infected sirs negative individuals tested data analyzed method creates complex data combinations based graphic patterns partitions data subsets approach partition data admission data sirs infection patients related day hospital mortality results non partitioning approach informative study study leukocyte data intervals non survivors survivors overlapped contrast combinatorial method distinguished two subsets later showed twofold larger differences mortality two subsets differ gender age microbial species antimicrobial resistance revealed different immune profiles non infected sirs negative individuals express high mortality profile longitudinal data septic patients displayed pattern associated highest mortality within first post admission suggesting inflammation coexisted immunosuppression one high mortality sub subset displayed high neutrophil lymphocyte ratio values low lymphocyte percents second high mortality subset showed monocyte mediated deficiencies numerous within subset comparisons revealed statistically significantly different immune profiles conclusion analysis non partitioned data result information loss complex combinatorial data structures uncover hidden patterns guide data partitioning subsets differ mortality rates immune profiles information facilitate diagnostics monitoring disease dynamics evaluation subset specific patient specific therapies
background facilitate priority setting health policymaking compiled best available information estimate adult mortality years burden attributable metabolic lifestyle infectious environmental risk factors taiwan methods obtained data risk factor exposure nationally representative health surveys cause specific mortality national death registry relative risks epidemiological studies meta analyses applied comparative risk assessment framework estimate mortality burden attributable individual risk factors risk factor clusters results high blood glucose accounted deaths deaths year followed tobacco smoking deaths high blood pressure deaths ambient particulate matter pollution deaths dietary risks high sodium intake low intake fruits vegetables deaths overweight obesity physical inactivity accounted deaths deaths respectively cardiometabolic risk factors high blood pressure high blood glucose high cholesterol overweight obesity jointly accounted deaths cardiovascular diseases domestic risk factors infections hepatitis virus hbv hepatitis virus hcv responsible deaths deaths respectively betel nut use associated deaths oral laryngeal esophageal cancer leading risk factors years life lost similar impact tobacco smoking alcohol use became larger attributable deaths risk factors occurred among young adults aged less years conclusions high blood glucose tobacco smoking high blood pressure major risk factors deaths diseases injuries among taiwanese adults large number years life would gained modifiable risk factors could removed reduced optimal level
background understand hiv drug resistance prefectures hebei province china implemented cross sectional hiv molecular epidemiological survey methods blood samples collected newly diagnosed drug naive hiv positive individuals antiretroviral therapy art failure individuals prefectures hebei province china patient demographic data obtained via face face interviews using standardized questionnaire blood samples collected genotyping hiv drug resistance implemented using house assay results study overall prevalence hiv prevalence hiv participants experiencing treatment failure art naive participants respectively mutations protease inhibitors nucleoside reverse transcriptase inhibitors nrtis non nrti nnrtis well dual multiple mutations extensively seen participants experiencing treatment failure proportions nnrti mutations chi dual mutations nrtis nnrtis chi participants experiencing treatment failure significantly higher art naive participants distributions mutations differed significantly among three main hiv genotypes identified viral load symptoms past months counts transmission route duration art found associated hiv conclusions results suggest new prevention control strategies formulated according epidemic characteristics hiv resistant strains hebei province antiretroviral drugs widely used
background extent serum cytokines may predict asthma control adults remains understudied objectives investigated cross sectional longitudinal associations cytokine profiles asthma outcomes methods serum interleukin tne alpha levels determined adults current asthma survey epidemiological study genetics environment asthma egea participants followed seven years later asthma symptom control assessed according gina guidelines cytokine profiles identified principal component analyses expressed median results first two pcs captured variability seven cytokines scored high scored high egea neither related exacerbations asthma attacks asthma symptom control lung function allergic diseases high level median associated higher blood neutrophil counts high level associated lower ige levels high level egea associated lower bronchial hyperresponsiveness adjusted subsequent lower risk worsening asthma control attacks aor respectively conclusions serum cytokine profiles high levels associated lower subsequent risks worsening asthma control attacks adults study adds new findings role serum cytokine profiles help identifying adults subsequent risk asthma burden could targeted specific therapies elsevier ltd rights reserved
background traumatic brain injury tbi major cause death disability may cause transient persistent isolated multiple hypopituitarism variable percentage cases objectives primary aim study determine incidence isolated multiple anterior pituitary hormone deficiency subjects tbi single institution secondary aim determine correlation pituitary deficiency quality life qol tbi methods thirty five patients aged years evaluated months years tbi evaluated qol questionnaire measured serum basal igf fsh testosterone males beta estradiol women prl tsh patients low igf ghrh arginine test performed results single multiple pituitary failure found patients low testosterone found males low fsh low igf patients hypogonadotropic hypogonadism insufficiency assessed ghrh arginine test found respectively patients one patient displayed concomitant insufficiency low tsh level twenty six patients showed reduction qol correlations altered qol hormonal deficiency observed conclusions isolated multiple hypopituitarism resulting tbi frequent alterations qol pituitary function resulting tbi associated ijs publishing group limited published elsevier ltd rights reserved
background treatment urgency urinary incontinence focused pharmacologically treating detrusor overactivity recent recognition altered perception internal stimuli interoception plays role urgency urinary incontinence suggests exploration abnormalities brain function disorder could lead better understanding urgency incontinence treatment objective sought evaluate relationship bladder filling perceived urgency activation brain sites within interoceptive network urgency urinary incontinence identify coactivation brain networks could affect interoception bladder filling urgency incontinence demonstrate interaction sites prior bladder filling evaluating resting state connectivity study design performed observational cohort study using functional magnetic resonance imaging compare brain function women urgency urinary incontinence controls whole brain voxelwise analyses covariance performed examine differences functional brain activation groups task consisting bladder filling hold static volume withdrawal phases task performed previously established levels baseline bladder volume highest exceeding strong desire void volume women continuously rated urge point likert scale throughout task mixed measures analysis variance used test differences urge ratings empirically derived regions interest analysis activation task used seeds examining group differences resting state functional connectivity results urgency urinary incontinent participants controls changes urge ratings greatest bladder filling initiated high baseline bladder volume urgency incontinent participants rating changes greater controls bladder filling phase urgency incontinent participant activation interoceptive network greater controls including left insula anterior middle cingulate cortex urgency incontinent participant activation also greater controls sites ventral attention network posterior default mode network urgency incontinent participant connectivity greater controls middle cingulate seed point dorsal attention network top attentional network control connectivity greater midcingulate seed point ventral attention network bottom attentional network conclusion increasing urge associated greater urgency incontinent participant control activation interoceptive network activation networks determinants self awareness default mode network response unexpected external stimuli ventral attention network differences connectivity interoceptive networks opposing attentional networks ventral attention network dorsal attention network present even bladder filling resting state findings strong evidence central nervous system component urgency urinary incontinence could mediated brain directed therapies
background tritrichomonas foetus emergent important enteric pathogen cats causes prolonged diarrhoea cats case presentation study describes foetus infection seven month old entire male domestic shorthair kitten six month history persistent large intestinal diarrhoea faecal incontinence prostration apathy weight loss parasites microscopically observed confirmed pcr dna sequencing molecular analyses carried comparing sequence obtained study foetus suis retrieved genbank treatment ronidazole cat showed resolution clinical signs conclusions first clinical case foetus infection chronic diarrheic cat brazil south america confirming presence pathogen part world highlighting importance protozoa considered differential diagnosis cats presenting diarrhoea large intestine case report enriches knowledge geographical distribution foetus cats brazil provides understanding clinical significance feline intestinal trichomoniasis country
background tuberculosis remains major global threat two billion world population latently infected mycobacterium tuberculosis risk progression active disease bacillus calmette guerin bcg licensed vaccine prophylaxis strategy protects children disseminated form tuberculosis therefore postexposure vaccine strategy targets individuals latent tuberculosis infection important strategy control disease globally objectives present study designed novel postexposure multi epitope dna construct based latency associated antigens rvc rvc rvc microtubule associated protein light chain hallmark protein autophagy system methods mouse construct designed based predicted mhc class class restricted cell epitopes fused together tandemly mhc class class restricted epitopes linked aay gpgpg motifs respectively directly fused mhc class restricted epitopes terminus peptide varieties expressed construct features analyzed bioinformatics tools finally construct codons optimized mrna structure optimized construct analyzed results mhc class class predicted epitopes showed high potential binding human hlas alleles global broad spectrum population coverage construct allergenicity analysis indicated desirable antigenicity construct construct several posttranslational modifications signal peptide cytoplasmic localization high score also mrna analysis showed low delta demonstrated high stability efficient translation conclusions results revealed novel multi epitope dna construct could effective candidate tuberculosis vaccine development qualified investigate potential induce cell immune response experimental animal model
background understanding risk factors may vary culturally help improve preventive strategies obesity first cross sectional study aimed determine risk factors overweight obesity children aged years central anatolian city turkey methods total children healthy overweight obese aged years included anthropometry turkish children aged years database age gender birth weight birth order mother age mother body mass index bmi weight gain mothers pregnancy presence gestational diabetes breastfeeding duration history formula feeding mother father education mother job monthly income smoking home physical activity sleep duration duration television watching children evaluated independent risk factors logistic regression analyses performed investigate risk factors overweight obesity results high family income compared bad odds ratio confidence interval increased time watching weekend similar physical activity level according peers compared less found significantly associated higher risk overweight obesity children aged years old conclusions early childhood period seems important establishment healthy behavioral patterns especially limitation watching encouragement physical activity obesogenic environment families high incomes need revealed
background unintended pregnancy complex phenomenon raise take emergency decision low contraceptive prevalence high user failure rates leading causes unexpected situation high user failure rates suggest vital role emergency contraception prevent unplanned pregnancy levonorgestrel commonly used progestin emergency contraception however little known pharmacokinetics optimal dose use hence need conduct systematic review available evidences methods randomized double blind trials sought evaluating healthy women regular menstrual cycles requested emergency contraception within unprotected coitus one three regimens single dose levonorgestrel two doses levonorgestrel given apart two doses levonorgestrel given apart primary outcome unintended pregnancy outcomes side effects timing next menstruation results every trial consideration successfully established contraceptive effectiveness levonorgestrel preventing unintended pregnancy moreover single dose levonorgestrel emergency contraception supports safety efficacy profile two doses levonorgestrel intended administration second dose positively taken first dose without compromising contraceptive efficacy main side effect frequent menstrual irregularities serious adverse events reported conclusions review shows emergency contraceptive regimen single dose levonorgestrel inferior efficacy two dose regimen regimens studied efficacious emergency contraception prevented high proportion pregnancies taken within unprotected coitus single levonorgestrel dose substitute two doses apart either regimen earlier treatment given effective seems
background unintended pregnancy important public health issue developing countries like india association adverse social health outcomes emergency contraception safe effective way prevent unplanned pregnancy objectives study assess attitude practices need assessment emergency contraception among married women years urban area delhi methods community based cross sectional study done urban locality central delhi pretested semi structured questionnaire used take interview eligible females results study subjects favourable attitude towards use emergency contraception future need arises siginificant association attitude age parity contraceptive usage study subjects ever used purchased emergency contraception chemist pill found common used study subjects practice found associated education contraceptive usage knowledge conclusion government health facilities first choice study subjects receiving information getting emergency contraceptive pills however unavailability emergency contraceptive pills health centres long waiting time government health facilities found reasons going government health facilities getting emergency contraceptive pills
background untold numbers women worldwide survivors intimate partner violence ipv substantial number experiencing occurring mental health substance use problems despite complex interconnections among problems funding mechanisms organizational structures mandates designed address single focal problem one challenges frontline providers lack effective evidence informed inter professional education training help identify appropriately respond occurring problems developed evidence informed competency based curriculum address gap paper report effectiveness increasing knowledge changing beliefs enhancing skills frontline workers three sectors methods curriculum consists multiple elements text manual interactive online series modules person workshop frontline workers violence women vaw mental health addiction treatment associated sectors recruited attend workshop instructed read manual complete online modules attending failed respond online pre post tests used assess changes knowledge beliefs skills evaluations workshop also collected results matched pre post tests available half participants results show statistically significant improvements across six competency domains pre post test significant changes participants knowledge stigmatizing beliefs achieved correlation among differences sector age size organization years experience prior training participant feedback made evident prior misconceptions women experiencing occurring problems improved understanding need bridge silos well need enhanced self care conclusions educational intervention designed sensitize frontline workers realities women experiences occurring problems educate challenges accessing help occurring problems bridge discipline practice based silos effectively challenge alter providers negative attitudes stigmatizing beliefs
background patients bipolar disorder history traumatic events associated greater episode severity higher risk comorbidity higher relapse rates trauma focused treatment strategies thus necessary studies currently scarce aim study examine whether eye movement desensitization reprocessing emdr therapy focusing adherence insight idealisation manic symptoms prodromal symptoms mood stabilization reduce episode severity relapse rates increase cognitive performance functioning patients methods design single blind randomized controlled multicentre trial patients history traumatic events recruited randomly allocated one two treatment arms emdr therapy supportive therapy patients groups receive psychotherapeutic sessions min months primary outcome reduction affective episodes months favour emdr group secondary outcome postulate greater reduction affective symptoms emdr group measured bipolar depression rating scale young mania rating scale clinical global impression scale modified better performance cognitive state social cognition functioning measured screen cognitive impairment psychiatry mayer saloveycaruso emotional intelligence test functioning assessment short test respectively traumatic events evaluated holmes rahe life stress inventory clinician administered ptsd scale impact event scale discussion results study provide evidence whether specific emdr protocol patients effective reducing affective episodes affective symptoms functional cognitive trauma
background urinary incontinence defined complaint involuntary leakage urine pregnancy prevalence urinary incontinence ranges different factors like demographic factors obstetric factors external factors affect urinary incontinence ethiopia study conducted far magnitude urinary incontinence factors associated among pregnant women objective study determine prevalence urinary incontinence associated factors among pregnant women following antenatal care university gondar hospital methods institution based cross sectional study conducted among pregnant women following antenatal care university gondar hospital data collected using structured questionnaire analyzed using spss version descriptive bivariate multivariate analyses performed results considered significant value result overall prevalence urinary incontinence among participants adjustment episiotomy constipation obese women chronic cough sneezing asthma allergies sinusitis associated urinary incontinence conclusions study lower prevalence found previous studies significant association urinary incontinence previous history episiotomy constipation maternal bmi respiratory problems
background uterine fibroids affect women menopause account billion annual healthcare costs type diabetes inconsistently associated protection ufs prior studies evaluate relationship ufs tested association risk large clinical population well potential differences due medications interaction race methods nested case control study derived clinical cohort outcome case control status exposure outcomes exposure classified using validated electronic medical record emr algorithms logistic regression adjusted covariates used model association diagnosis risk secondary analyses performed evaluating interaction exposure race stratifying exposed subjects medication taken results identified subjects outcomes cases controls diabetic non diabetic observed nominally significant interaction exposure race adjusted models interaction race stratified analyses demonstrated protection exposure risk among european americans adjusted odds ratio aor african americans aor also observed protective effect regardless type medication taken slightly protection among subjects insulin treatments european americans aor african americans aor conclusions data conducted large population cases controls support prior studies found protective association diabetes presence risk modified race protection ufs exposure observed regardless medication type slightly protection among insulin users mechanistic research larger cohorts necessary reconcile potential role risk
background venous thromboembolism vte potentially fatal complication orthopedic surgery recently antithrombotic compounds available postoperative thromboprophylaxis introduction non vitamin antagonists oral anticoagulants noac including apixaban extended therapeutic armamentarium field therefore estimation noac net clinical benefit comparison established treatment needed inform clinical decision making objectives systematic review assess efficacy safety apixaban twice day versus low molecular weight heparins lmwh thromboprophylaxis patients undergoing knee hip replacement data sources medline embase central searched inception september systematic reviews reference lists experts consulted study eligibility criteria participants intervention major orthopedic surgery randomized controlled trials comparing apixaban twice daily lmwh reporting thrombotic bleeding events data extraction two independent reviewers using predetermined form study appraisal synthesis methods cochrane tool assess risk bias used two independent authors revman software used estimate pooled risk ratio confidence intervals using random effects meta analysis trial sequential analysis tsa performed statistical significant results evaluate whether cumulative sample size powered obtained effect overall confidence cumulative evidence assessed using grading recommendations assessment development evaluation grade working group methodology results four studies comparing apixaban twice daily lmwh included total patients undergoing knee hip replacement overall risk bias across studies low comparison lmwh regimens apixaban showed significantly lower risk vte events overall mortality combined major vte events symptomatic vte events vte related mortality combined trial sequential analysis showed risk reduction obtained vte mortality based underpowered cumulative sample size effect dimension subgroup analysis according lmwh regimens showed apixaban reduced risk vte events overall mortality major vte events compared lmwh daily without differences apixaban lmwh twice daily conclusions low moderate evidence patients undergoing knee hip replacement apixaban seems equally effective safe lmwh twice day compared lmwh day apixaban seems superior thromboprophylaxis option however results underpowered precludes definite answers regarding true net clinical benefit apixaban versus lmwh clinical context
background verbal memory impairment prominent bipolar disorder linked functional outcomes however intricacies impairment yet studied large sample patients moreover proposed deficits may mediated organizational strategies semantic serial clustering thus exact nature break patients well understood limiting remediation efforts investigated intricacies deficits patients versus healthy controls hcs examined whether verbal learning differences mediated use clustering strategies methods california verbal learning test cvlt administered affectively stable patients hcs compared diagnostic groups cvlt indices investigated whether group differences verbal learning mediated clustering strategies results although patients showed significantly poorer attention learning memory indices mildly impaired however patients evidenced poorer use effective learning strategies lower recall consistency indices falling moderately impaired range moreover relative reliance semantic clustering fully mediated relationship diagnostic category verbal learning reliance serial clustering partially mediated relationship conclusions deficits affectively stable bipolar patients widespread generally mildly impaired however patients displayed inadequate use organizational strategies clear separation hcs semantic serial clustering remediation efforts may benefit education mnemonic devices chunking techniques attenuate deficits
background vitamin thought contribute brain health unclear whether low vitamin levels associated increased incidence parkinson disease using ultraviolet surrogate vitamin levels conducted nationwide ecologic study france order examine association incidence methods used french national drug claims databases identify cases using validated algorithm data solar radiation database derived satellite images estimated incidence canton level small administrative french unit used multilevel poisson regression examine association annual average adjustment age sex deprivation index density neurologists smoking proportion agricultural land vitamin supplementation results analyses based incident patients association incidence quadratic modified age incidence higher bottom quintile relative risk rrq compared middle quintile lower top quintile rrq opposite pattern observed older subjects rrq rrq analysis based continuous yielded similar conclusions conclusions nationwide study age dependent quadratic association incidence study suggests reasonable exposure associated lower risk younger persons future studies examine dose response relations take age account
background aimed evaluate potential benefits leadership coaching health leach program physical activity dietary habits distress management cancer survivors methods randomly assigned cancer survivors allocation ratio two one leach program group coached long term survivors usual care group baseline months used scores intake vegetables fruits post traumatic growth inventory ptgi primary outcomes secondary outcomes ten rules highly effective health behavior adhered quality life qol hospital anxiety depression scale hads european organization research treatment cancer quality life questionnaire eortc qlq results primary outcomes two groups significantly differ scores intake differed marginally ptgi secondary outcomes group showed significantly greater improvement hads anxiety score social functioning score appetite loss financial difficulties scores eortc qlq scales baseline months baseline months group showed significantly greater decrease eortc qlq fatigue score significantly greater increase number ten rules highly effective health behavior conclusion findings indicate leach program coached long term survivors provide effective management qol cancer survivors dietary habits
background compared effect propofol sevoflurane combined remifentanil comparable bispectral index bis levels transcranial electric motor evoked potentials tcemeps somatosensory evoked potentials sseps brainstem surgery materials methods total consecutive patients per group undergoing brainstem surgery randomly assigned groups receiving either mac sevoflurane propofol effect site concentration maintenance anesthesia remifentanil administered groups rate min along cisatracurium tcemep recordings carried abductor pollicis brevis abductor hallucis tibialis anterior muscles whereas cortical sseps measured posterior tibial nerve stimulation amplitudes latencies tcemeps sseps recorded hours induction anesthesia results bis values remained range amplitudes tcemeps significantly higher propofol group sevoflurane group study time points abductor pollicis brevis abductor hallucis muscles anesthetic induction tibialis anterior muscle whereas latencies shorter propofol group sevoflurane group differences observed latency amplitude recording sseps anesthetic techniques none patients tcemeps sseps amplitude latency changes exceeding set limit conclusions sevoflurane propofol low dosages combined remifentanil comparable bis values partial muscle relaxation used monitoring tcemeps sseps required brainstem surgery
background strong understanding health care organization capacity attempting completing multiple sometimes competing change initiatives capacity change implementation critical success factor health care industry faced ongoing demands change transformation technological advances market forces regulatory environment purpose aim study develop validate tool measure health care organizations capacity change building upon previous conceptualizations absorptive capacity organizational readiness change methodology approach multistep process used develop organizational capacity change survey survey sent two populations requesting answers questions organization leadership culture technologies use throughout organization exploratory confirmatory factor analyses conducted validate survey measurement tool organizational capacity change health care setting findings resulting organizational capacity change measurement tool proves valid reliable method evaluating hospital capacity change measurement population perceptions related leadership culture organizational technologies practical implications organizational capacity change measurement tool help health care managers leaders evaluate capacity employees departments teams change large scale implementation
background examine association leisure time activities risk developing cognitive impairment among chinese older people investigate whether association varies educational level methods follow study included participants aged years range years female chinese longitudinal healthy longevity survey aged years free cognitive impairment incident cognitive impairment defined survey following education based cut adapted chinese version mini mental state examination mmse participation cognitive activities reading non exercise physical activity housework assessed self reported scale cox proportional hazard models employed examine association leisure activities incident cognitive impairment controlling age gender education occupation residence physical exercise smoking drinking cardiovascular diseases risk factors negative well physical functioning baseline mmse score results five year follow participants developed incident cognitive impairment overall high level participation leisure activities associated decreased risk cognitive impairment compared low level engagement leisure activities controlling age gender education confounders moreover significant interaction leisure activity educational level beneficial effect leisure activities cognitive function larger educated elderly uneducated counterparts educated elderly benefited cognitive activities conclusions late life leisure activities protect cognitive impairment among elderly chinese people protective effects profound educated elderly
background whether gastrointestinal motor sensory function primary cause secondary effect abnormal body weight uncertain moreover studies relating continuous postprandial sensations satiation measurable pathology scarce work assessed postprandial gastrointestinal function concurrent sensations satiation across wide range body weight weight change methods patients anorexia nervosa obesity investigated reference normal weight controls additionally investigated longitudinally gastric emptying antral contractions oro cecal transit ingestion solid meal investigated mri lactose ureide breath test dependency self reported sensations satiation varying degree stomach filling gastric emptying compared groups results bmi studied gastric half emptying time slower negative association bmi observed bmi antral contractions oro cecal transit different given gastric content volume self reported postprandial fullness greater weight rehabilitation tended become shorter postprandial fullness less marked conclusions relationship body weight gastric emptying well self reported feelings satiation present slower gastric emptying heightened visceral perception compared longitudinal follow weight rehabilitation suggests abnormalities primary feature secondary factors determine abnormal body weight
background opiate substitution therapy injecting equipment provision iep reduced blood borne viruses bbv among people inject drugs pwid pwid continue share injecting equipment acquire bbv psychosocial interventions address risk behaviours could reduce bbv transmission among pwid methods pragmatic two armed randomised controlled open feasibility study pwid attending drug treatment iep four regions ninety nine pwid randomly allocated receive three session manualised psychosocial group intervention bbv transmission information booklet plus treatment usual tau information booklet plus tau intervention developed evidence based literature qualitative interviews pwid key stakeholder consultations expert opinion recruitment rates retention treatment followup completion rates health economic data completion measured feasibility results fifty six percent eligible pwid recruited participants attended least one intervention session london north wales glasgow york participants attended sessions compared attending least one session likely homeless injected drugs greater number days median used greater number needles iep last month median adverse events reported followed month post intervention feedback forms confirmed intervention acceptable intervention facilitators participants attended follow attendance associated fewer days injecting last month median fewer injections cocaine analysis questionnaires identified several service use questionnaire categories could excluded assessment battery full randomised controlled trial conclusions findings interpreted caution due small sample sizes future definitive rct psychosocial intervention feasible complex needs pwid may limited engagement intervention flexible delivery methods may greater reach
background health related benefits intimate partnership well documented little attention paid couples exposed high levels social stigma exclusion project investigated important site stigma partnerships collecting accounts changing hepatitis hcv status sero change among couples inject drugs explored accounts reveal meaning hcv couples understanding contributes collective efforts prevention care methods drawing large dataset qualitative interviews couples focussed containing reports sero change adopting methodology positioned partnerships rather individuals primary unit analysis addressed commonplace tendency either overlook discount dysfunctional sexual relationships people inject drugs results couples sought greater biomedical understanding means coming terms sero change others drew alternative logics rationalities sat firmly outside conventional biomedical discourse privileging notions kinship example regardless explanatory framework drew participants ultimately prioritised security relationship dangers viral infection conclusions effectively engaging couples hcv prevention care requires acknowledging working competing priorities complex realities partnerships beyond simply identification viral risk new era direct acting antiviral treatments provide ongoing opportunities learn integrate biomedical information within socially sophisticated relationally aware approaches elsevier rights reserved
background marked increase prevalence diabetes mellitus purpose study assess potential association time cumulated exposure systolic cumsbp diastolic blood pressure cumdbp onset impaired glucose tolerance diabetes mellitus methods prospective investigation included participants longitudinal kailuan study three baseline examinations examination diabetes mellitus baseline cumulative blood pressure calculated cumbp time time based cumsbp study population stratified four groups cumsbp mmhgxyear mmhgxyear cumsbp mmhgxyear mmhgxyears cumsbp mmhgxyears results adjusting demographic anthropomorphic biochemical socioeconomic lifestyle parameters compared first group second third fourth group showed significantly higher incidence diabetes trend hazard ratio confidence interval respectively higher incidence impairment glucose tolerance trend respectively higher incidence diabetes developing impairment glucose tolerance trend respectively increase cumsbp mmhg year increase cumdbp mmhg year associated hazard ratio incident diabetes respectively hazard ratio incident impairment glucose tolerance respectively hazard ratio incident diabetes developing impairment glucose tolerance respectively conclusions time cumulated exposure elevated blood pressure significantly associated elevated incidence impaired glucose tolerance diabetes
background minamata convention use mercury phased undoubtedly effect dental treatment regimens economic resources composite resin restorations considered viable alternatives amalgam fillings however covered completely health insurance systems many countries recently high viscosity glass ionomer cement hvgic processed resinous coating introduced marketed restorative material load bearing class cavities class cavities limited size thus serving possible alternative amalgam fillings objective discuss outcome based evaluation presented part paper critically appraise methodologies various studies results two included studies industry funded status clinical trials remained unclear quality study reporting considered perfectible use light cured nanofilled resin coating material would seem advantageous least regarding short medium term outcomes conclusion within respective indications cavity geometries hvgic approach would seem promising could merge phase mercury objectives minimally invasive treatment extent might restorative alternative patients suffering allergies willing afford sophisticated expensive techniques recommendations based studies evaluating equia fil transferable clinical perspectives glass hybrid successor product equia forte
background women receiving radiation breast likely recommended use topical cream minimize delay development radiation dermatitis although many topical products commercially available tested safety efficacy studies compared various products one another superiority cost effectiveness objectives purpose pilot study compare three commonly used skin care products prospectively one homogenously controlled group women undergoing whole breast irradiation assess superiority minimizing common toxicity criteria grade radiation dermatitis effect quality life cost methods authors conducted systematic review determine three types skin care products strongest evidence minimizing radiation dermatitis patients voluntarily enrolled randomized one three possible skin care topical regimens patients completed quality life survey assess preference topical skin care regimen cost arm topical product assessed completion patient participation findings statistical difference noted severity occurrence radiation dermatitis among groups addition statistical difference found among three treatment arms quality life score changes patients required treatment interruption radiation skin care product treatment cost difference among treatment arms noted
background work related stress highly prevalent educational sector aim current study evaluate effectiveness organizational level participatory intervention need recovery vitality educational workers hypothesized intervention would decrease need recovery increase vitality methods quasi experiment conducted two secondary vocational education training schools months follow measurements intervention consisted needs assessment phase wherein staff teachers developed actions happy healthy working supervision facilitator implementation phase wherein actions implemented management teams mixed model analysis applied order assess differences intervention control group average time analyses corrected baseline values several covariates results effects intervention found need recovery vitality secondary outcomes two small statistically significant effects unfavorable direction intervention group scored average time significantly lower absorption subscale work engagement organizational efficacy control group conclusions since beneficial effects intervention found primary secondary outcomes implementation intervention current form eligible recommend future organizational level interventions occupational health incorporate elaborate implementation strategy specific relating actions stressors context integrated secondary preventive individual focused stress management interventions
background xiao qixingcha exq extensively applied relieve dyspepsia constipation children hundreds years china however therapeutic mechanism underlying efficacy remained defined present study aimed clarify possible laxative immune regulating effects exq two models experimental constipation mice mimicked pediatric constipation caused high heat high protein diet hhpd methods two models constipated mice induced hhpd hhpd atropine respectively investigate laxative immune regulating activities exq animals treated three doses exq consecutive days fecal output parameters number weight weight intestinal content thymus spleen indexes measured levels siga tnf alpha lps colon serum determined elisa furthermore pathological changes colon tissue examined routine staining results hhpd hhpd atropine treatments obviously inhibited fecal output reduced colonic siga prominently increased levels tnf alpha colonic tissue elevated contents lps serum colonic tissues contrast oral administration exq significantly improved feces characters dose dependently decreased intestinal changes models hhpd model test exq efficaciously boosted siga level dose dependent manner significantly elicited decreases tnf alpha levels evidently decreased spleen thymus indexes hhpd atropine model test exq treatment reversed pathological changes dramatically decreasing spleen index levels lps also markedly elevating thymus index furthermore microscopic observation revealed exq treatment maintained integrity colonic mucosa protected colonic tissues inflammation models conclusions exq exhibited prominent laxative activity effectively protected colonic mucosal barrier two models constipated mice mechanism might closely associated propulsive immune regulating properties current results validated rationale clinical application exq pediatric constipation related symptoms also threw new light immune inflammatory responses accompanied chronic constipation pathology
background horizontal advancement genioplasty extremely rewarding microgenia however challenging even experienced surgeon determine three dimensional position distant bone fragment operation study aimed apply evaluate computer aided design cad computer aided manufacturing techniques horizontal advancement genioplasty improve surgical accuracy methods seven patients microgenia prospectively enrolled study preoperative postoperative computed tomography photographs lateral cephalograms performed computer aided design done based preoperative data surgical templates cutting guide templates fixation templates designed accordingly guide horizontal advancement genioplasty surgeries performed junior surgeons accuracy authors method evaluated relative error mean value discrepancy postoperative preoperative design points selected randomly preoperative design movement position error postoperative advancement preoperative cad advancement preoperative cad advancement position error postoperative downward movement preoperative cad downward movement preoperative cad downward movement calculated geomagic automatically results patients satisfied aesthetic outcomes average absolute relative error average absolute position error average absolute position error value conclusions authors study showed applying computer assisted techniques horizontal advancement genioplasty provided accurate surgical result technique best result horizontal advancement genioplasty could achieved even inexperienced surgeons
background discharge phone call dpc important initiative aimed improving transitions care reducing readmissions added importance financial penalties imposed hospitals excessive medicare readmissions study examines impact dpcs percentages patients reached dpcs hospital readmission rates based centralized noncentralized mode dpcs methods health system centralized studer group discharge phone call program one central call center goals reaching discharged patients ultimately reduce hospital readmissions study analyzed hospital visits patient admissions could result unplanned hospital readmission hospital discharge data analyzed august january primary outcomes included dpcs reaching discharged patients effects hospital readmission rates result centralizing dpc program results centralized dpcs significantly associated increases percentage patients reached dpc turn reduces readmissions rates patients reached times likely readmitted patients reached centralized dpcs conclusions centralizing dpc program within call center helps reach patients reduce readmission rates compared noncentralized dpcs
backgroundq deletion syndrome qds genetic disorder greatly increases risk developing schizophrenia previously characterized cerebral surface morphology trajectories late childhood mid adolescence cohort youth qds herein extend study period early adulthood describe trajectories associated severe psychiatric symptoms cohort methodsparticipants included youth qds unaffected siblings assessed three timepoints high resolution anatomic magnetic resonance images acquired high dimensional nonlinear warping algorithms applied images order derive characteristics cerebral surface morphology participant timepoint repeated measures linear regressions using mixed model conducted covarying age sex resultsalterations cerebral surface morphology late adolescence early adulthood individuals qds observed lateral frontal orbitofrontal temporal parietal occipital cerebellar regions age diagnosis interaction revealed relative unaffected siblings individuals qds showed age related surface protrusions prefrontal cortex remained stable increased early adulthood surface indentations posterior regions seemed level late adolescence symptoms psychosis associated trajectory surface indentations orbitofrontal parietal regions conclusionsthese results advance understanding cerebral maturation individuals qds provide clinically relevant information psychiatric phenotype associated longitudinal trajectory cortical surface morphology youth genetic syndrome
backgroundan extensive clinical literature noted gender differences etiology clinical characteristics individuals alcohol dependence despite knowledge many important questions remain methodsusing national epidemiologic survey alcohol related conditions examined differences sociodemographic characteristics psychiatric medical comorbidities clinical correlates risk factors treatment utilization patterns men women lifetime resultsmen lifetime likely women diagnosed substance use disorder antisocial personality disorder whereas women likely mood anxiety disorders adjusting sociodemographic characteristics gender differences psychiatric comorbidity general population associated externalizing disorders mood disorder among women men met criteria longer episodes younger age first drink gender differences remission rates women likely family spouse history alcohol use disorders treatment rates low genders women likely report social stigmatization treatment barrier conclusionsthere important gender differences psychiatric comorbidities risk factors clinical characteristics treatment utilization patterns among individuals lifetime
backgroundbph luts associated obesity hypogonadism metabolic syndrome mets mets induced prostate bladder alterations including inflammation tissue remodeling related low testosterone high estrogen milieu addition ers gpr gper able mediate several estrogenic non genomic actions methodssupplementing subgroup mets rabbits tamoxifen analyzed vivo effects mets induced prostate bladder alterations effects selective gper ligands gper silencing prostate inflammation also studied vitro using hbph cells resultser expression upregulated mets bladder tamoxifen decreased expression stimulating addition tamoxifen dosing decreased mets induced overexpression inflammatory tissue remodeling genes prostate sex steroid receptors pro inflammatory pro fibrotic genes upregulated mets however tamoxifen affect even increased cox hbph cells estradiol increased secretion effect blunted treatment gper antagonist antagonist ici increased gper agonist dose dependently induced secretion vitro analysis demonstrated gper silencing reverted stimulatory effects conclusionsgper considered main mediator estrogen action prostate whereas bladder mechanism appears rely indicated vivo experiments tamoxifen dosing limiting effects mets induced estrogen action via gper could offer new perspectives management bph luts whereas tamoxifen dosing showed potential benefits bladder prostate wiley periodicals inc
backgroundchildren parents intellectual impairment thought risk poor social emotional well study investigated relationship maternal intellectual impairment poor child social emotional well methodsecondary analysis data waves millennium cohort study social emotional well measured maternal report waves teacher child self report wave bivariate multivariate analyses conducted resultsunadjusted maternal intellectual impairment associated elevated risk overall poor social emotional well ages age controlling individual family environmental characteristics statistically significant association found maternal intellectual impairment poor child social emotional well conclusionschildren mothers intellectual impairment likely peers exposed adverse living conditions living conditions may explain least part children face heightened risk poor social emotional well ages improving living conditions mothers intellectual impairment may offer pathway child social emotional well
backgroundchronic fatigue syndrome myalgic encephalomyelitis cfs characterised unexplained fatigue least months accompanied diverse consistent set symptoms diet modification nutritional supplements could used improve patient outcomes fatigue quality life reviewed discussed evidence nutritional interventions may assist alleviating symptoms cfs methodsmedline cinahl scopus systematically searched may studies nutrition intervention included cfs patients modified diet supplemented habitual diet patient centred outcomes fatigue quality life physical activity psychological wellbeing resultsseventeen studies included meet inclusion criteria different interventions investigated study outcomes many studies show therapeutic benefit cfs improvements fatigue observed nicotinamide adenine dinucleotide hydride nadh probiotics high cocoa polyphenol rich chocolate combination nadh coenzyme conclusionsthis review identified insufficient evidence use nutritional supplements elimination modified diets relieve cfs symptoms studies limited number studies investigating interventions small sample sizes study duration variety instruments used studies reporting dietary intake method research warranted homogeneous cfs populations
backgroundcraniocervical dystonia focal segmental dystonia distribution classically known spasmodic torticollis pure cervical presentation although craniocervical dystonia recognized possible cause headache since publication second version international classification headache disorders studies entity methodthis narrative review resultscraniocervical dystonia associated muscle pain cases headaches kind affected approximately patients craniocervical dystonia located mainly occipital cervical regions headache attributed craniocervical dystonia specifically rarely found described one patient one study treatment botulinum neurotoxin considered first line treatment focal dystonias including craniocervical dystonia besides reducing clinical severity impairment pain scores among patients craniocervical dystonia also descriptions improvements headaches attributed craniocervical dystonia headaches associated dystonia conclusionsheadache attributed craniocervical dystonia poorly studied need studies evaluate characteristics treatment
backgrounddiets reduced low carbohydrates becoming increasingly popular replacement foods accompanying nutrients determine health effects diets however little known dietary intake people consuming reduced low carbohydrate diets methodsin cross sectional study dietary nutrient intake individuals aged years consuming less energy carbohydrate compared individuals consuming equal energy carbohydrate using national diet nutrition survey resultsthose consuming less total energy carbohydrate reported higher consumption red processed meat butter oily fish vegetables well lower consumption soft drinks pulses normal carbohydrate intake adjusting socio economic status red meat intake different groups reached maximum recommended daily intake daily intake significant differences micronutrient intakes groups although magnesium selenium potassium along fibre lower recommended amounts across cohort conclusionsindividuals consuming reduced low carbohydrate diets could benefit replacing red meats white meats vegetable sources protein increasing vegetable intake
backgroundfarm exposure protects development allergies early life years protection asthma farm milk exposure partially mediated regulatory cells tregs aim study investigate critical time window asthma protective farm effect via tregs childhood immune maturation methodstregs assessed longitudinally years children farm reference children pasture efraim birth cohort flow cytometry peripheral blood mononuclear cells cultured unstimulated phorbol myristate acetate ionomycin lipopolysaccharide lps stained tregs high foxp upper mrna expression treg associated cell markers measured vivo suppressive capacity tregs effector cells cytokines assessed detailed questionnaires assessing farm exposures clinical phenotypes birth age years answered parents resultstreg percentage stimulation foxpmrna expression vivo decreased age years lps foxp high low farm milk animal stable exposure associated decreased lps stimulated treg percentage age years lps elevated lps stimulated treg percentage age associated increased risk asthma aor tregs asthmatics nonasthmatics suppressed ifn less efficiently mrna expression associated cell markers decreased years conclusionstregs age years decreased farm exposure increased within asthmatics opposite age years immunological switch defines critical time window treg mediated asthma protection via environmental exposure age years
backgroundfatigue frequent symptom patients irritable bowel syndrome ibs associated poor quality life however studies evaluated impact daily life perceived distress cause using multi methods approach study describes impact manifestations fatigue patients ibs investigates relationship fatigue severity illness related health promoting factors methodsa total patients ibs completed self reported questionnaires assessing fatigue gastrointestinal symptoms psychological distress sense coherence fatigue assessed fatigue impact scale also includes structured open ended questions analyzed deductive qualitative analysis patients classified severe moderate mild fatigue based frequency distress impact daily life key resultsthe open ended questions revealed multidimensional impact life fatigue mainly interfered ability perform physical activities work domestic work ability interact socially decreased stamina evident along strategies limit bodily consequences tiredness severe fatigue accompanied severe ibs symptoms anxiety depression lower sense coherence conclusions inferencesfatigue distressing symptom occurs sizeable proportion patients ibs affects life multidimensional way poor bodily stamina prominent feature fatigue along sense coherence depression anxiety needs assessed confirmed targeted interventions
backgroundhepatic venous pressure gradient hvpg measurement correlates staging liver fibrosis patients nonalcoholic steatohepatitis nash different pattern fibrosis compared hepatitis virus hcv possible alterations pressures aimthe aim study compare portal pressures stage fibrosis nash comparison liver diseases patients methodsrecords patients undergone transjugular liver biopsy pressure measurements january june reviewed wedge hepatic venous pressure whvp hvpg compared stages fibrosis liver diseases different etiologies resultsamong patients included study liver disease etiology follows hcv nash remaining grouped categories mean age patients years men hcv compared nash terms etiology strong correlations stage fibrosis hvpg whvp nash patients compared hcv patients nash patients lower hvpg mmhg stage coefficient estimate whvp mmhg stage stage fibrosis conclusionhvpg whvp measurements strongly correlated stages fibrosis nash patients nash lower hvpg whvp stage fibrosis compared hcv patients raises concern underestimation pressures hvpg nash etiology stage disease increased fibrosis despite lower pressures copyright wolters kluwer health inc rights reserved
backgroundknowledge kidney disease among general population poor assessed population selected referral nephrology care aimthis study aimed determine patients understanding chronic kidney disease ckd first presenting nephrology clinic methodsnewly referred patients nephrology clinic surveyed open ended questions understanding ckd causes symptoms management resultstwo hundred ten patients surveyed median age years interquartile range female mean body mass index prevalence risk factors ckd included diabetic hypertension family history ckd aboriginal torres strait islander ckd stage prevalence eighty two per cent referred primary care physician seen nephrologist previously kidney health australia mentioned sixteen per cent unsure referred ckd causes identified patients unsure alcohol hypertension diabetes symptoms identified included asymptomatic kidney pain management suggested patients uncertain dialysis anti hypertensive medication eighty two per cent reported unsatisfactory education primary care physician conclusionsnew patients referred renal outpatient department poor knowledge kidney disease education patients begin primary care prior referral patients education programmes need targeted simplistic level
backgroundlittle known comparative effectiveness safety non vitamin antagonist oral anticoagulants noac compared warfarin chinese atrial fibrillation patients aim compare ischemic stroke risk reduction incidence intracranial hemorrhage ich warfarin relation quality anticoagulation control reflected time therapeutic range ttr dabigatran rivaroxaban real world cohort chinese patients hypothesisnoac rather warfarin preferred chinese patients methodsof patients studied years female cha vasc bled nonvalvular patients warfarin ttr patients rivaroxaban patients dabigatran resultsafter mean follow months ischemic strokes annual incidence year incidence ischemic stroke highest patients warfarin ttr year followed rivaroxaban year warfarin ttr year whereas patients dabigatran lowest incidence ischemic stroke year incidence ich lowest patients dabigatran year compared rivaroxaban year warfarin ttr year ttr year patients rivaroxaban daily similar ischemic stroke risk year ich risk year compared dabigatran conclusions chinese patients benefits warfarin therapy stroke prevention ich reduction depend ttr treatments compared dabigatran well rivaroxaban daily associated lowest ischemic stroke ich rates
backgroundlongitudinal population based studies natural history allergic sensitization rare aim study incidence persistence airborne allergen sensitization young adulthood risk factors early late onset sensitization methodsall children aged years two municipalities northern sweden invited parental questionnaire skin prick tests spts ten airborne allergens participated protocol repeated age years participated three examinations resultsprevalence positive spt increased age years years years animals primary sensitizers age years followed pollen mite mold sensitization low mean annual incidence positive spt varied per year decreased age animal stable pollen sensitization age years independently associated family history allergy urban living male sex negatively associated birth order furry animals home incidence age years associated family history allergy multisensitization age years significantly associated early age sensitization remission sensitization uncommon conclusionthe increasing prevalence allergic sensitization age explained high incidence persistence age years factors urban living number siblings male sex lost importance
backgroundlow defined decreased triiodothyronine normal thyroid stimulating hormone tsh thyroxin levels present many acute diseases related increased mortality studied low level relation long term mortality non elevation acute coronary syndrome nste acs patients methodst tsh levels consecutive nste acs patients measured patients normal tsh levels low level defined low group patients normal tsh levels defined normal group clinical laboratory findings two groups compared addition examined low level relation early long term mortality resultsmean patient age male patients low level free values negatively correlated age serum creatinine brain type natriuretic peptide values time admission respectively mortality month year higher low group respectively multivariate analysis low found related mortality year roc analysis free good area curve auc value mortality year auc conclusionlow related increased early late mortality nste acs patients free levels may used identify nste acs patients high mortality risk
backgroundmost studies brain white matter posttraumatic stress disorder ptsd focused combat trauma often confounded neurological substance dependence comorbidity study used tract based spatial statistics tbss probabilistic tractography characterize microstructure mixed sex community sample ptsd patients exposed diverse multiple traumas trauma exposed normal comparison tenc subjects methodstbss compared diffusion measures adults dsm ptsd tenc using whole brain voxel wise approach probabilistic tractography using freesurfer tracula employed measure diffusion tensor imaging dti metrics within anatomically defined pathways dti metrics compared groups correlated ptsd symptom severity trauma load resultscontrolling age sex motion ptsd subjects significantly reduced fractional anisotropy left frontal lobe cluster compared tenc family wise error corrected tractography identified significant group differences inferior longitudinal fasciculus ilf including lower higher radial diffusivity ptsd compared tenc within ptsd group values correlated symptom severity trauma load results remained significant removing participants using psychotropic medication comorbid major depression conclusionsptsd patients reduced integrity left hemisphere frontal temporal occipital tracts compared trauma exposed controls reduced frontal consistent compromised top attentional control emotion regulation ptsd reduced ilf may related sensory processing gating abnormalities disorder
backgroundneglect often overlooked adolescence due part assumptions autonomy misinterpretation behaviors part normal adolescent development emotional maltreatment abuse neglect damaging effect throughout lifespan rarely recognized amongst adolescents review aims identify features adolescents experiencing neglect emotional maltreatment report methoda rapid review methodology searched databases supplemented hand searching journals references identifying abstracts two independent reviews undertaken articles trained reviewers using standardised critical appraisal eligible studies primary studies children aged years substantiated neglect emotional maltreatment containing self reported features results publications studies included demonstrating associations neglect emotional maltreatment internalising features studies including depression post traumatic symptomatology anxiety emotional maltreatment associated suicidal ideation neglect study neglect associated alcohol related problems studies substance misuse studies delinquency boys study teenage pregnancy study general victimization girls study emotionally maltreated girls reported externalising symptoms study dating violence victimization associated neglect emotional maltreatment studies emotional abuse boys neglect associated dating violence perpetration study neither neglect emotional maltreatment association low self esteem studies neither neglect emotional maltreatment effect school performance study neglected boys showed greater school engagement neglected girls study conclusionsif asked neglected emotionally maltreated adolescents describe significant difficulties mental health social relationships alcohol substance misuse practitioners working youths exhibit features recognize detrimental impact maltreatment developmental stage identify whether maltreatment contributory factor addressed
backgroundnursing plays central role facilitating care transitions complex older adults yet consensus components nurse led care transitions interventions facilitate high quality care transitions among complex older adults structured expert panel established purpose identifying effective nurse led care transition interventions methodsa modified delphi consensus technique based rand method employed panelists asked individually rate series statements derived realist synthesis literature relevance feasibility likely impact statements receiving aggregate score reviewed revised face face consensus meeting second round rating following process round one used followed final ranking statements resultsthe five highest ranked intervention components contextual factors educating coaching patients family members caregivers self management skills ensuring patients family members caregivers aware follow medical appointments postdischarge care plan using standardized documentation tools comprehensive communication strategies care transitions optimizing nurses roles scopes practice across care transitions spectrum strong leadership strategic alignment accountability structures organizations enable quality care transitions complex older person population linking evidence actionkey insights optimizing nurses roles scope practice care transitions included nurses provide warm hand offs serve person panel also identified current challenges optimizing nurses roles scope practice across care transition points future research required determine effective nurse led intervention components context work
backgroundpain acceptance involves willingness experience pain engaging valued activities pain present though pain acceptance could limit headache related disability pain interference individuals migraine studies addressed issue study evaluated whether higher levels total pain acceptance two subcomponents pain willingness activity engagement associated lower levels headache related impairment women migraine overweight obesity methodsin cross sectional study participants seeking weight loss headache relief women health migraine trial completed baseline measures pain acceptance chronic pain acceptance questionnaire cpaq headache related disability headache impact test pain interference brief pain inventory migraine headache frequency pain intensity assessed daily via smartphone diary using cpaq total subcomponent pain willingness activity engagement scores headache frequency pain intensity body mass index bmi predictors linear regression headache related disability pain interference modeled outcomes resultson average participants age years bmi reported migraine days month pain intensity scale headache days correcting multiple comparisons adjusted pain willingness independently associated lower headache related disability pain interference activity engagement associated headache related disability pain interference cpaq total score associated headache related disability pain interference pain intensity significantly associated outcomes analyses conclusionshigher pain willingness independent degree migraine severity overweight associated lower headache related disability general pain interference treatment seeking women migraine overweight obesity future studies needed clarify direction causality test whether strategies designed help women increase pain willingness relinquish ineffective efforts control pain improve functional outcomes women migraine overweight obesity
backgroundpatients ehlers danlos syndromehypermobility type eds increased prevalence gastrointestinal symptoms particularly reflux dyspepsia eds associated dysautonomia psychopathology chronic pain associated symptoms association symptoms eds non patient population effect mentioned factors never studied methodsin cross sectional study hypermobility questionnaire used screen university students clinical examination established diagnosis eds validated questionnaires assessed somatic pain autonomic symptoms psychopathology quality life qol compared students without eds logistic regression analysis examined associations eds symptoms variables key resultsof students screened included eds years female non eds years female compared non eds students eds students likely multiple symptoms particularly postprandial fullness early satiety greater autonomic association eds postprandial symptoms dependent autonomic factors independent pain psychopathology pain related qol scores reduced eds group conclusions inferencesthe previously described association eds dyspepsia pain autonomic symptoms patients also present non patient groups future studies necessary explore etiological role connective tissue extra intestinal symptoms
backgroundpatients posttraumatic stress disorder ptsd often share morbidity chronic pain conditions recent studies suggest role receptors atp signaling pain conditions however underlying mechanisms visceral hyperalgesia following exposure ptsd like stress conditions remain unclarified methodsthe behavior hormones relevant ptsd studied visceromotor responses vmr abdominal withdrawal reflexes awr colorectal distention crd recorded determine receptor mediated alteration hyperalgesia following single prolonged stress sps exposure immunofluorescence western blotting patch clamp used key resultsthe escape latency adrenocorticotropic hormone cortisol increased days visceromotor responses awr reduced day sps rats increased higher levels controls exposure day intrathecal administration receptor antagonist tnp atp abolished crd response based immunofluorescence western blotting analysis sps treated rats exhibited reduced expression dorsal root ganglia drg day compared controls expression drg enhanced day sps increase expression maintained day compared controls receptor agonist atp induced fast desensitizing inward current drg neurons control sps treated rats average peak current densities sps treated group increased fold tnp atp markedly blocked fast atp induced inward currents drg neurons control sps treated rats conclusions inferencesthe data indicate important role signaling visceral hyperalgesia following ptsd like stress
backgroundpeanut allergy children often associated allergies tree nuts legumes aim study analyze cluster cohort children allergic peanuts assessed cross reactivity nuts legumes identify different phenotypes methodswe included retrospectively children peanut allergy evaluated allergy unit saint vincent hospital lille last years complete workup peanut allergy nuts legumes carried patient hierarchical agglomerative clustering method used search clusters individuals evaluated cohort resultscross allergy legumes identified patients atopic dermatitis major risk factor adjusted three phenotypes emerged cluster analysis cluster patients characterized high level rara low threshold reactive doses peanut high proportion asthma cluster patients characterized high threshold reactive doses peanut lowest proportion cross allergy legumes cluster patients high risk cross allergy legumes patients suffer eczema conclusionsthe three phenotypes highlighted study could useful identify children high risk cross allergic reaction tns legumes early diagnosis
backgroundposaconazole active available azole antifungal drug absorption pharmacokinetics available guide dosing regimens cats objectiveto determine pharmacokinetics posaconazole cats given solution suspension animalssix healthy adult research cats methodsafter hour fast cat received posaconazole suspension food four cats also received posaconazole day washout period plasma collected predetermined intervals analysis using high pressure liquid chromatography hplc concentration data analyzed using compartment pharmacokinetic analysis administration data compartment analysis first order input administration data using phoenix software resultsafter dosing volume distribution mean standard deviation terminal half life hours clearance dosing peak concentration max hours bioavailability suspension adverse effects observed either route administration conclusion clinical importancedespite low absorption data allow simulation dosage regimens could explored clinical studies two regimens considered maintain targeted trough concentrations extrapolated studies humans loading dose followed loading dose followed
backgroundprior work shows post traumatic stress disorder ptsd predicts increased risk preterm birth causal pathway uncertain evaluate associations ptsd antepartum complications explore ptsd pathophysiology impacts pregnancy methodsthis retrospective cohort analysis veterans health administration covered deliveries used data clinical administration mothers current ptsd identified using icd diagnostic codes code present antepartum year historical ptsd medical administrative data used identify relevant obstetric diagnoses demographics health military deployment history used poisson regression robust error variance derive adjusted relative risk estimates association ptsd five clinically relevant antepartum complications gestational diabetes gdm preeclampsia gestational hypertension growth restriction abruption secondary outcomes included proxies obstetric complexity repeat hospitalisation prolonged delivery hospitalisation caesarean delivery resultsof singleton deliveries mothers ptsd diagnoses current ptsd mothers complication gdm preeclampsia births adjustment current ptsd diagnosis reference ptsd associated increased risk gdm confidence interval preeclampsia ptsd also predicted prolonged day delivery hospitalisation repeat hospitalisations caesarean delivery conclusionsthe observed association ptsd gdm preeclampsia consistent nascent understanding ptsd disruptor neuroendocrine cardiovascular health
backgroundrecent human studies evaluated effect daily apple consumption plasma cholesterol level recognized important risk factor cardiovascular disease cvd nevertheless slightly significant effects generally registered although consuming two apples day several weeks resultsthis study describes influence daily consumption annurca apples cholesterol levels mildly hypercholesterolaemic healthy subjects monocentric randomized parallel group placebo controlled month study conducted subjects randomly assigned five treatment groups one subjects men women four groups administered one apple per day among following red delicious granny smith fuji golden delicious fifth group asked consume two annurca apples per day since weight cultivar average half commercial ones considered study comparing results annurca led significant outcome allowing reduction total low density lipoprotein cholesterol levels respectively increase high density lipoprotein cholesterol levels conclusionour data would reasonably indicate annurca apple useful tool contribute prevention cvd risk normal diet society chemical industry
backgroundreports positive effects aerobic exercise cognitive function persons syndrome extremely limited however novel exercise intervention termed assisted cycling therapy act resulted acutely improved cognitive planning ability reaction times well improved cognitive planning weeks act adolescents young adults syndrome report effects weeks act reaction time set shifting inhibition language fluency adolescents syndrome methodsadolescents syndrome age similar years randomly assigned weeks act voluntary cycling convenience sample assigned inactive comparison group act cycling cadence participants augmented average cadence faster voluntary cadence group increase cadence achieved electric motor stationary bicycle reaction time set shifting inhibition language fluency assessed weeks intervention resultspower output heart rates act groups almost identical act cadence significantly faster act group groups showed significantly improved reactions times hedges inhibitory control group showed improved set shifting ability act groups displayed improved semantic language fluency respectively discussionsthese previous results support hypothesis increased neuroplasticity prefrontal cortex function following act smaller extent following act appear associated cortical benefits based current previous results act seems maximize benefits
background school cardiopulmonary resuscitation cpr training become mandatory many countries whether legislation translated implementation cpr training largely unknown assessed cpr training students following years legislative mandates denmark methods results nationwide cross sectional survey danish school leadership ninth grade homeroom teachers carried school year qualitative interviews theory planned behavior used construct survey logistic regression models employed identify factors associated completed cpr training information eligible schools collected leadership teachers responded according teachers eligible classes completed cpr automated external defibrillator training respectively among leadership reported cpr training occurred years prior survey factors associated completed cpr training included believing schools conducting training odds ratio awareness mandating legislation presence school cpr training coordinator teacher feeling competent conduct training easy access training material conclusions despite mandating legislation school cpr training successfully implemented completed cpr training associated believing schools conducting training awareness mandating legislation presence school cpr training coordinator teachers teacher feeling competent conduct training easy access training material facilitating factors may increase rates school cpr training
backgroundsilkworm pupae good resource edible oil especially rich unsaturated fatty acids considered excellent dietary supplement hyperlipidemia resultsgroups fed high cholesterol diet hcd silkworm pupae oil spo supplementation mlkg day orally significantly lower levels serum total cholesterol low density lipoprotein cholesterol compared hcd group regard antioxidant parameters except levels glutathione peroxidase gsh liver mlkg day spo supplementation leaded higher total antioxidant capacity superoxide dismutase gsh levels well lower malondialdehyde levels serum liver compared hcd group conclusionthe results present study indicate supplementation spo improve lipid profiles alleviate oxidative stress high cholesterol diet fed rats society chemical industry
backgroundtemporal discounting refers tendency rewards lose value expected delay receipt increases individuals anorexia nervosa found show reduced temporal discounting rates indicating greater preference delayed rewards compared healthy peers obsessive compulsive disorder ocd social anxiety disorder sad commonly occur anxiety related development prognosis examined whether reduced temporal discounting present across potentially related disorders explored relationship temporal discounting anxiety transdiagnostically methodsone hundred ninety six individuals healthy controls ocd sad completed two temporal discounting tasks chose smaller sooner larger later monetary rewards two measures discountingdiscount rate discount factorwere compared diagnostic groups associations anxious traits examined resultsindividuals showed decreased temporal discounting compared ocd sad groups differ significantly across sample anxiety associated decreased discounting anxious individuals showed greater preference delayed reward conclusionswe replicated findings individuals show increased preference delayed reward relative individuals ocd differ also showed individuals sad differ discounting across large sample two measures anxious temperament associated temporal discounting data raise new questions relationship dimensional trait psychopathology
backgroundthe absence abnormalities noninvasive cardiac assessment possibly confers reduced risk atrial fibrillation despite presence traditional risk factors hypothesisnormal findings noninvasive cardiac assessment associated lower risk development methodswe examined clinical utility normal findings routine noninvasive cardiac assessment participants white women cardiovascular health study free baseline combination normal electrocardiogram ecg normal echocardiogram assessed development events normal ecg defined absence major minor minnesota code abnormalities normal echocardiogram defined absence contractile dysfunction wall motion abnormalities abnormal left ventricular mass cox regression used compute year risk developing resultsduring year study period total events detected normal ecg multivariable hazard ratio confidence interval normal echocardiogram multivariable associated reduced risk isolation association improved normal ecg normal echocardiogram multivariable compared participants abnormal ecg abnormal echocardiogram referent conclusionsnormal findings routine noninvasive cardiac assessment identify persons risk low studies needed explore utility profile regarding decision implement certain risk factor modification strategies older adults reduce burden
backgroundthe current recommendation treatment latent tuberculosis infection ltbi solid organ transplant candidates isoniazid months treatment main problem frequently reaching posttransplant period methodsthis study efficacy safety month regimen isoniazid rifampicin lung transplant candidates reina sofia hospital cordoba resultsthree hundred ninety eight lung transplant patients evaluated ninety two ltbi received treatment one additional patient treated history previous incomplete treatment active none treated patients developed posttransplant tuberculosis compared three patients ltbi treated three patients could conclude treatment two adverse effects conclusionstreatment ltbi lung transplant candidates using short course appears effective safe preventing posttransplant lung transplant recipients
backgroundthe first classification angioedema without wheals recently reported comprises different forms disease distinguished aetiology mediator oedema inheritance methodsin total consecutive patients angioedema without wheals examined centre excluded analysis patients incomplete data angioedema related specific factor resultsaccording new classification angioedema patients included analysis diagnosed hereditary hae acquired angioedema aae former group included hae inhibitor inh deficiency inh hae hae normal inh levels six factor xii mutation fxii hae disease unknown origin hae aae group included disease inh deficiency inh aae aae related angiotensin converting enzyme inhibitor treatment idiopathic histaminergic aae idiopathic nonhistaminergic angioedema inh aae compared hereditary aae uncertain aetiopathogenesis fxii hae hae groups pooled fxii hae versus inh aae median age onset fxii hae inh aae years respectively addition patients fxii hae inh aae reported five attacks per year median duration location angioedema patients fxii hae versus inh aae following face versus tongue oral cavity larynx versus limbs versus gastrointestinal mucosa versus prophylaxis tranexamic acid effective six patients hae inh aae started treatment conclusionour findings cohort patients angioedema provide new information clinical characteristics diagnosis treatment disease
backgroundthe majority patients psoriasis mild moderate disease managed primary care topical therapies supportive role pharmacists patients long term dermatological conditions largely unknown objectiveto assess impact educational intervention delivered community pharmacists improve self management people psoriasis methodthe study involved pre post intervention design seven community pharmacies selected based location urban rural etc pharmacists recruited via local comprehensive research networks patients mild moderate psoriasis recruited either opportunistically via letter invite pharmacists undertook face face consultation one follow visit weeks primary outcome change person centred dermatology self care index pedesi score secondary outcomes self assessed psoriasis severity index sapasi measuring disease severity dermatology quality life index dlqi key findingsa total patients recruited weeks patients completed follow consultation significant increase mean pedesi scores versus weeks compared baseline similarly sapasi versus dlqi versus scores improved significantly conclusionpharmacist assisted support patients psoriasis improved knowledge reduced disease severity impact quality life results suggest community pharmacists might important role play facilitating self management patients psoriasis
backgroundthere limited literature data migraine like accompanying features mlf patients cluster headache symptoms frequently reported patients may delay diagnosis objectivethe aim present study investigate occurrence migraine like symptoms italian case series patients determine whether features influence clinical phenotype methodsa cross sectional study performed consecutive patients referred parma headache centre affected cases subsequently reviewed applying ichd beta criteria initial study sample consisted subjects men women identified patients reported least one migraine accompanying symptoms nausea vomiting photophobia phonophobia resultswe found patients mlf men initial male sample women initial female sample patients without mlf men initial male sample women initial female sample multiple logistic regression analysis highlighted demographic clinical features significantly characterized patients mlf adjusting confounding frequently female relatively younger age onset expected attacks longer duration accompanied frequent ptosis sweating miosis osmophobia also frequently reported conclusionour study confirms high proportion patients mlf reported literature presence mlf seems relate peculiar demographic clinical characteristics sufferers whether features influence response therapy remains determined
backgroundvegetarian diets may associated certain benefits toward human health although current evidence scarce contrasting present study systematic review meta analysis prospective cohort studies performed respect association vegetarian diets breast colorectal prostate cancer risk methodsstudies systematically searched pubmed embase electronic databases eligible studies prospective design compared vegetarian semi pesco vegetarian diets non vegetarian diet random effects models applied calculate relative risks rrs cancer diets statistical heterogeneity publication bias explored resultsa total nine studies included meta analysis studies conducted six cohorts accounting individuals cases breast colorectal prostate cancer respectively none analyses showed significant association vegetarian diet lower risk either breast colorectal prostate cancer compared non vegetarian diet contrast lower risk colorectal cancer associated semi vegetarian diet confidence interval heterogeneity pesco vegetarian diet confidence interval heterogeneity compared non vegetarian diet subgroup analysis cancer localisation showed differences summary risk estimates colon rectal cancer conclusionsa summary existing evidence cohort studies vegetarian diets showed complete exclusion source protein diet associated benefits human health
bacterial colonization gut shapes local systemic immune response implicated modulation immunity healthy disease states recently quantitative qualitative changes composition gut microbiota detected crohn disease ulcerative colitis reinforcing hypothesis dysbiosis relevant mechanism underlying inflammatory bowel disease ibd pathogenesis humans microbes coexisted evolved long time mutually beneficial symbiotic association essential maintaining homeostasis however microbiome dynamic changing age response environmental modifications among environmental factors food alimentary habits progressively altered modern societies appear critical modulators microbiota contributing participating dysbiosis addition food constituents micronutrients important regulators mucosal immunity direct indirect effects gut microbiota moreover food constituents recently shown modulate epigenetic mechanisms result increased risk development progression ibd therefore likely better understanding role different food components intestinal homeostasis resident microbiota essential unravelling complex molecular basis epigenetic genetic environment interactions underlying ibd pathogenesis well offering dietary interventions minimal side effects
bad blood revisited attachment psychoanalysis article attempts trace intellectual history relationship tachment theory psychoanalytic thinking considers discourse two fields authors describe points convergence well areas continuing contention suggest future directions attachment work bearing relation ship psychoanalysis particular mentalizing theory discussed line thinking draws attachment ideas psychoanalysis recent developments mentalizing described within argument future development attachment thinking two constructs connected attachment mentalizing epistemic trust concept general factor psychopathology discussed along implications ideas thinking common factors effective psychotherapeutic interventions share
badly scaled matrix pencils could reduce reliability accuracy computed results many numerical problems including computation eigenvalues deflating subspaces needed many key procedures optimal infinity control model reduction spectral factorization standard balancing techniques improve results many cases situations solution scaled problem much worse unscaled problem paper presents new structure preserving balancing technique skew hamiltonian hamiltonian matrix pencils illustrates good performance solving eigenvalue problems algebraic riccati equations large sets examples well known benchmark collections difficult examples
barriers access long term complications remain challenge transplantation advancements may achieved research priority setting patient engagement strengthen relevance evaluated research priority setting solid organ transplantation described stakeholder priorities databases searched october synthesized findings descriptively studies participants addressed kidney heart liver lung pancreas nonspecified organ transplantation using consensus conferences expert panel meetings workshops surveys focus groups interviews delphi technique nine reported patient involvement research priorities addressed following organ donation priorities studies waitlisting allocation studies histocompatibility immunology studies immunosuppression studies graft related complications studies recipient non graft related complications studies reproduction study psychosocial lifestyle studies disparities access outcomes studies priorities identified broad one third initiatives engaged patients caregivers details process lacking setting research priorities explicit manner patient involvement guide investment toward shared priorities patients health professionals
bartlett developed procedures repeated reproduction person repeatedly recalling information serial reproduction people transmitting information one person another experiment directly compared recall accuracy across two techniques previously reported using drm word lists recall initial study list words remained constant across repeated reproductions declined markedly across serial reproductions contrast recall associated words originally studied critical words steady across conditions original list words forgotten across link serial reproduction chain proportion critical items recalled relative list words increased significantly list passed people using output bound scoring serial reproduction resulted lower accuracy repeated reproduction final recall trial results broadly consistent bartlett informal observations serial reproduction produces greater forgetting original material repeated reproduction also leads greater distortion relative proportion correct material recalled society applied research memory cognition published elsevier inc rights reserved
basal cell carcinomas bcc squamous cell carcinomas scc common malignancies humans caused neoplastic transformation keratinocytes basal suprabasal layers epidermis respectively tumor infiltrating lymphocytes tils frequently found bcc scc functionally promote epithelial carcinogenesis tils secreting particular participate bcc scc growth inducing keratinocyte proliferation migration well expression inflammatory anti apoptotic pro angiogenic genes study identified socs valid candidate manipulated suppressing tumorigenic functions bcc scc found socs socs expression reduced vivo tumor lesions bcc scc compared skin inflammatory conditions psoriasis despite high number secreting tils moreover able induce vitro transcriptional expression socs bcc scc derived keratinocytes contrarily healthy cells aimed rescuing socs activity tumor contexts socs derived peptide named kir ess synthesized ability suppressing induced responses evaluated healthy transformed keratinocytes found kir ess peptide efficiently suppressed molecular signaling keratinocytes acting stat erk cascade well expression stat dependent downstream genes interestingly treatment peptide healthy transformed keratinocytes could longer aberrantly proliferate migrate response finally treatment athymic nude mice bearing scc xenografts kir ess peptide concomitantly reduced tumor growth activated stat levels whole data provides rationale use bcc scc skin tumors socs mimetics able inhibit deleterious effects contexts
base bleed important extended range technology wherein low speed mass flux injected high temperature using ammonium perchlorate based burning composite propellant range projectile increased effectively controlling burning rate propellant study burning rate type bimodal hydroxyl terminated polybutadiene htpb base bleed composite propellant measured ground free ambient pressure atm using laser ignition highspeed video image processing technology difficult determine existing burning rate bimodal htpb base bleed composite propellant numerical calculation model burning rate constructed numerical calculation result agrees well experimental value elsevier masson sas rights reserved
based case report overview differential diagnostic considerations respect blood hypereosinophilia hypereosinophilic syndromes hes childhood given year old boy admitted clarification asthma blood count increased found along elevated total serum ige level lung function showed obstruction fev radiologically picture bronchiectasis mucus pluggine appeared bal raised level apparent histologically asthma diagnosed mucostasis hypertrophy bronchial wall musculature lung differential diagnostically abpa churg strauss syndrome parasitosis drug associated allergies malignant disease could excluded aberrant cell clone peripheral blood detected flow cytometry cell receptor clonal rearrangements pcr leading diagnosis lymphoid variant hes hes failure detect fipl pdgfra gene fusion normal bone marrow examination could exclude neoplastic hes hesn steroid initiation prompt decrease blood eosinophilia resolution symptoms observed steroid discontinuation led eosinophilia recurrence associated disease symptoms steroid sparing agent immunosuppressive azathioprine additionally given steroid doses could decreased stopped course case demonstrated range evaluation infancy asthma one also consider possibility hes
based method proposed authors new tension stiffening law proposed short term deformational analysis flexural reinforced concrete members derived experimental moment curvature diagrams beams reported authors quantitative dependence established length descending branch reinforcement ratio proposed relationship applied simple engineeing technique based layered approach principles strength materials assess accuracy technique deflections curvatures calculated large number experimental reinforced concrete beams reported literature comparison carried proposed relationship design code methods aci eurocode new russian code
based aggression theories previous researches examined effects viewing violent movie via computer aggressiveness among college students total females undergraduates participated study distributed violent movie group allocated non violent movie group results indicated aggressiveness violent movie group non violent movie group significantly strengthened moreover aggressiveness males females significantly enhanced among violent movie group instead non violent movie group aggressiveness viewers high aggression low aggression significantly enhanced among violent movie group instead non violent movie group males viewers violent movie significantly intensify aggressiveness indicating gender aggressive level responsible aggressiveness among college students implications findings discussed elsevier ltd rights reserved
based comprehensive analysis structure potential safety problem oil gas scada supervisor control data acquisition network aiming shortcomings traditional evaluation methods combining factor state space fuzzy comprehensive evaluation method new network security risk evaluation method oil gas scada proposed first formal description factor state space complete mathematical definition presented secondly factor fuzzy evaluation steps discussed using analytic hierarchy method evaluation index system oil gas scada system established index weights factors determined two two comparisons structure design three layers reasoning machine completed experiments tests show proposed method accurate reliable practical research results provide template new method industries elsevier ltd rights reserved
based fredrickson broaden build theory positive emotion explored role school affect positive affect school negative affect school connecting gratitude prosocial behavior school satisfaction among sample males elementary school students grades using structural equation modeling participants completed packet questionnaires including gratitude questionnaire elementary school students subjective well school scale essswbss primary school upper grade students prosocial behaviors questionnaire psugspbq results showed elementary school students positive affect school negative affect school significantly related school satisfaction prosocial behavior fully mediated relation gratitude school satisfaction gratitude related school satisfaction indirectly positive affect school negative affect school hypothesized effect stronger positive affect school limitations practical applications study discussed
based generalized bilinear forms lump solutions rationally localized directions space dimensionally reduced gkp gbkp equations dimensions computed symbolic computation maple sufficient necessary conditions guarantee analyticity rational localization solutions presented resulting lump solutions contain six parameters two totally free due translation invariance four need satisfy presented sufficient necessary conditions three dimensional plots particular choices involved parameters made show energy distribution
based integration thought cdio standard cdio education idea model laboratory system controlling engineering cdio mode studied three integration features system analyzed taking construction control engineering laboratory example overall structure concrete connotation system clarified three key segments establishing laboratory system proposed analyzed namely strengthening construction experimental teaching staff innovating experiment management system optimizing approach laboratory construction
based aerodynamic interaction heaving vortex induced vibration torsional flutter another explanation drastic change vibrational mode symmetrical heaving mode asymmetrical torsional mode introduced fundamental characteristics coupled flutter thin plate plate like structure flutter modes flutter branches explained use step step flutter analysis flutter properties obtained dof multi modes flutter analysis compared ones dof modes flutter analysis dof multi modes flutter analysis recommended use accurate verification flutter property lessons aerodynamic behavior full scale elastic model akashi kaikyo bridge reduction key equivalent aerodynamic derivatives suitable span wise arrangement girders different girder shapes significantly effective stabilize flutter instability long spanned suspension bridge furthermore significantly similar formula selberg formula derived simple assumptions application coupled flutter generation mechanism propulsion force use coupled flutter motion introduced finally confirmed mode produce propulsion force test ship navigation flapping plate controlled particular flutter mode shown elsevier ltd rights reserved
based characteristics teaching problems electronic technology courses paper proposed use multisim simulation software whole process analog electronic technology teaching integrating theory practice teaching strengthen theory teaching make lack hardware experimental teaching teaching practice basic amplifier integrated operational amplifier core components analog electronics example analysis based integration theory practice teaching methods multisim stimulate students interest learning improve learning initiative enhance understanding content students learned well practical abilities developing sense innovation achieving ideal teaching effect
based depth analysis basic principle non stationary parallel hot wire method existing measuring standards foundation heat transfer differential mathematical model hot wire cylindrical coordinates research made measurement method solid materials thermal conductivity thermal diffusivity temperature measuring points originally arranged parallel hot wire changed specimen thickness direction combined computer programming numerical algorithms used directly measure materials thermal conductivity thermal diffusivity without looking table analyzes detail effect heat penetration measurement results explores treatment measures develops device thermo physical properties measurement measuring experiments conducted thermo physical properties glass asbestos diatomite bricks others experimental results close compliance individual thermo physical properties tester literature values less relative error
based invariant subspace method symbolic computation scheme corresponding maple package developed construct exact solutions nonlinear evolution equations symbolic computation scheme crucial step constructing linear differential equations invariant subspaces systems evolution equations admin taking solutions subspaces construct exact solutions maple package proved provide easy way constructing exact solutions evolution equations automatically inputting several necessary parameters three different types examples given illustrate scope demonstrate validity package especially wave equation results examples reveal polynomial subspaces trigonometric subspaces exponential subspaces complex subspaces invariant subspaces evolutions equations admit addition maple software package provides helpful easy use tool science engineering deal wide variety dimensional nonlinear evolution equations
based methodology understanding design ubd course design hydraulic structures developed implemented series learning experiences emphasis hydraulics hydrology civil engineering undergraduate students presented encourages development high technical scientific competence communication skills oral written ability teamwork capability learn experiences designed using methodology based learning desired taught course results obtained compared based planned framework expectations characterization student population course products well activities according students considered relevant learning process
based orthogonal superposition theorem three alternating magnetic components universal uniform magnetic spin vector superimposed using tri axial helmholtz coils achieving successive digital control orientation rotational speed magnetic flux density universal magnetic spin vector increasing magnitude orientation accuracy magnetic spin vector paper presents mathematical model associated magnitude error orientation error universal magnetic spin vector along double error compensation method magnitude orientation universal magnetic spin vector superimposed three alternating magnetic components double error compensation method includes current magnitude compensation three different structural coefficients tri axial helmholtz coils current phase compensation two relative phase differences linear polarization results shown double compensation method increase magnitude orientation accuracy rotating magnetic vector effectively would achieve accurate posture adjustment steering control capsule robots curving environment
based unit cell concept analytical solutions presented predict deformation behaviors geotextile encased stone columns depth top plane columns vertical loads tops stone columns axial compression deformation occurs often accompanied lateral expansion near top deformation characteristic stone columns incorporated directly proposed analytical method shear stress encased stone column surrounding soil vertical direction also taken account method confining pressure provided soil analyzed based analogy passive earth pressure method verified via comparison two analytical solutions parametric studies conducted investigate effects geotextile encasement vertical applied stress column spacing diameter deformation behaviors columns results indicated geotextile encasement higher stiffness beneficial effect reducing column bulging settlement moreover selection geotextile stiffness encased stone columns done relation column diameter spacing increased column diameter decreased spacing great effect settlement reduction
basic emotion theory suggests effectiveness different emotion regulation strategies vary intensity emotionally salient stimulus although findings studies using healthy samples concordant proposed theory unclear whether relationships hold true among individuals borderline personality disorder bpd twenty five individuals bpd hcs exposed negative images varying levels emotional arousal instructed either react normally would distract use mindful awareness self reported negativity ratings heart rate skin conductance level scl monitored throughout scl data indicated increases image arousal resulted larger reductions scl distracting implementing mindful awareness self report data suggested hcs effectiveness mindful awareness decreased greater extent distraction image arousal increased findings consistent basic emotion research suggest forms emotion regulation distraction suited high emotion arousal contexts others mindful awareness compared hcs individuals bpd may resilient deteriorating effectiveness mindful awareness respect increasing emotional arousal elsevier ireland ltd rights reserved
bat inspired algorithm bia recently explored develop novel algorithm distributed optimization control paper bia based design model predictive controllers mpcs proposed load frequency control lfc enhance damping oscillations power systems proposed model predictive load frequency controllers termed mplfcs two area hydro thermal system equipped mplfcs considered accomplish study suggested power system model considers generation rate constraint grc governor dead band gdb time delays imposed power system governor turbine thermodynamic process communication channels accounted well bia utilized search optimal controller parameters minimizing candidate time domain based objective function performance proposed controller compared conventional controller based integral square error ise technique controller optimized genetic algorithms order demonstrate superior efficiency bia based mplfcs simulation results emphasis better performance proposed mplfcs compared conventional based controllers wide range operating conditions system parameters uncertainties elsevier ltd rights reserved
cell novel protein bcnp family member famc identified cell specific plasma membrane protein bioinformatics analysis predicted bcnp might heavily phosphorylated bcnp protein contains pleckstrin homology domain two proline rich regions leucine zipper domain suggesting may involved protein protein interactions using cancer genome atlas tcga data sets investigated correlation alteration bcnp copy number changes mutations several cancer types also investigated function bcnp cellular signalling pathways found bcnp highly altered types cancers bcnp copy number changes mutations occur molecular alteration events tumour protein pikca phosphatidylinositol bisphosphate kinase catalytic subunit alpha mapk mitogen activated protein kinase erk extracellular signal regulated kinase kras kirsten rat sarcoma viral oncogene homolog akt akt murine thymoma viral oncogene homolog also found pik phoshoinositide kinase inhibition mapk mitogen activated protein kinase activation leads reduction phosphorylation bcnp serine residues suggesting bcnp phosphorylation pik pmapk dependent might involved cancer degradation depends proteasome mediated pathway
cardiovascular disease remains major cause mortality morbidity world wide remains compelling need new insights novel therapeutic avenues regard senescence accelerated mouse prone samp line particularly good model studying effects aging cardiovascular health accumulating evidence suggests model may shed light age associated cardiac vascular dysfunction disease animals manifest evidence inflammation oxidative stress adverse cardiac remodeling may recapitulate processes involved human disease early alterations oxidative damage promote endoplasmic reticulum stress trigger apoptosis cytokine production genetically susceptible mouse strain conversely pharmacological treatments reduce inflammation oxidative stress improve cardiac function animals therefore samp mouse model provides exciting opportunity expand knowledge aging cardiovascular disease potential identification novel targets treatment herein review previous studies performed samp mice provide insight age related cardiovascular alterations elsevier rights reserved
data dissemination crucial wireless sensor networks wsns energy efficiency reliability paramount importance achieving two goals together highly nontrivial situation exacerbated wsn nodes duty cycled transmission power adjustable paper study problem minimizing expected total transmission power reliable data dissemination multicast broadcast wsns due hardness problem design efficient approximation algorithms provable performance bounds facilitate algorithm design propose novel concept time reliability power trp space general data structure designing data dissemination algorithms wsns performance ratios algorithms based trp space proven log delta log multicast broadcast delta maximum node degree network number source destination nodes involved data dissemination session also conduct extensive simulations firmly demonstrate efficiency algorithms
health care demand among ibs patients imposes heavy economic burden identifying high utilizers potential improving quality efficiency care previous research identified reliable predictors utilization ibs patients sought identify factors predictive health care utilization among severe ibs patients ibs patients completed testing whose content mapped onto andersen model health care utilization stage hurdle models used determine predictors health care use probability frequency separate analyses conducted mental health medical services whether patients used medical care predicted diet insurance status tobacco use education health insurance predicted probability using mental health care frequency medical care associated alcohol use physical health status frequency mental health services associated marital status tobacco use education distress stress control beliefs ibs symptoms ibs patients demand health care involves complex decision making process influenced many factors particularly strong determinants include predisposing characteristics dietary pattern tobacco use enabling factors insurance coverage impede facilitate demand factors impact use depends whether focus decision use care much care used decisions use medical mental health care simply influenced symptom specific factors variety lifestyle dietary pattern education smoking economic insurance coverage factors elsevier ltd rights reserved
nature one dimensional structure good conductivity excellent ballistic transport property single walled carbon nanotubes considered important nanomaterial building new generation electrical circuits article mainly focus two strategies developed installing diverse functionalities single walled carbon nanotube based molecular transistors nanolithographic method surface chemical modification overcome ill defined contacts molecules electrodes highlight current effort direction creation reliable single molecule devices using carboxylic acid functionalized single walled carbon nanotubes nanogapped point contacts contacts made high resolution electron beam lithography oxygen plasma oxidative etching electrically functional molecules covalently bridged nanogaps robust amide linkages thus forming stable molecular electronic devices results open new opportunities develop unique single molecule biosensors high selectivity high speed hold great promise industrial applications basic scientific researches
problems existing setting professional development trend material forming control engineering specialty core curriculum leading problems rigid core curriculum value deviation core curriculum proportion time arrangement paper based value chain proposes optimization scheme material forming control engineering specialty core curriculum first paper discusses problems existing core courses explains value chain finally optimizes core curriculum value chain theory considering external internal resources factors influencing core curriculum comprehensively finally achieves consistency external resources internal resources gets optimal value
scour contributed collapse large number bridges many researchers tried find general method predicting scour prevent failure bridge foundations however existing scour depth equations recommended federal highway administration fhwa united states generally give excessively conservative estimates scour depth one reason equations based primarily idealized simplified laboratory experiments rectangular flumes addition idealized simplified laboratory experiments another possible reason scour depth overprediction current practice adding separate estimates contraction scour local scour fact processes occur simultaneously interact study focuses specifically hydraulic modeling local pier scour contraction scour scaled field site constructed hydraulics laboratory georgia institute technology based froude number similarity used several flow rates including year peak flood discharge historical flood discharge field measurements provided geological survey usgs used compare scour measurements contraction scour local scour laboratory field based findings procedure hydraulic modeling scaled field geometry suggested
begin robotics successful open online course developed university reading run futurelearn platform around participants enrolled first three runs whilst aimed introducing robotics associated subjects cybernetics artificial intelligence control haptics key stage pupils taken groups around world paper discusses control engineering introduced accessible way used undergraduate degrees
beginning infancy diagnosis made children autism spectrum disorder asd show significant impairments foundation social communication interactions including eye gaze contexts requesting joint attention addressing early impairments early possible toddlers receive diagnosis asd provides foundational social communication repertoire necessary learning study examined effects social communication intervention involving prompting reinforcement teach gaze shift shifting gaze object interventionist eyes context responding request initiating four toddlers asd intervention lasted weeks toddlers demonstrating mastery across contexts toddlers also showed generalization repertoire social communication behavior including initiating requests increases smiling improvements symptoms asd overall functioning observed results suggest promising brief intervention address earliest form social communication remains part successful social communication interactions throughout life
behaviors involving interaction multiple individuals complex frequently crucial animal survival interactions ranging across sensory modalities length scales time scales often subtle difficult characterize contextual effects frequency behaviors become even difficult quantify physical interaction animals interferes conventional data analysis due visual occlusion introduce method quantifying behavior fruit fly interaction combines high throughput video acquisition tracking individuals recent unsupervised methods capturing animal entire behavioral repertoire find behavioral differences solitary flies paired individual opposite sex identifying specific behaviors affected social spatial context pipeline allows comprehensive description interaction two individuals using unsupervised machine learning methods used answer questions depth complexity variance fruit fly courtship
behavioural variant frontotemporal dementia bvftd idiopathic normal pressure hydrocephalus inph neurodegenerative diseases present similar symptoms include decline executive functions psychomotor slowness behavioural personality changes ventricular enlargement key radiological finding inph may also present bvftd caused corf expansion mutation due bvftd hypothesized potential comorbidity inph bvftd patients never identified studies focusing clinical comorbidities inph describe patient corf expansion associated bvftd also showed enlarged ventricles brain imaging main clinical symptoms severe gait disturbances psychiatric problems mild cognitive decline cerebrospinal fluid removal increased patient walking speed ventriculoperitoneal shunt placed insertion shunt significant improvement walking speed well mild improvement cognitive function neuropsychiatric symptoms relating bvftd comorbid inph considered bvftd patients enlarged ventricles severely impaired gait
appropriately aware extent stress experienced daily life essential motivating stress management behaviours excessive stress underestimation obstructs process expected exert adverse effects health prospectively examined associations stress underestimation mental health outcomes japanese workers web based surveys conducted twice interval year japanese male workers participants asked complete survey items concerning stress underestimation depressive symptoms sickness absence antidepressant use multiple logistic regression analysis revealed high baseline levels overgeneralization stress insensitivity stress significantly associated new onset depressive symptoms antidepressant use respectively year follow period study clearly demonstrated stress underestimation including stress insensitivity overgeneralization stress could exert adverse effects mental health
complex non linear coupled system robotic manipulator effectively controlled using classical proportional integral derivative pid controller enhance effectiveness conventional pid controller nonlinear uncertain systems gains pid controller conservatively tuned adapt process parameter variations work mix locally recurrent neural network mlrnn architecture investigated mimic conventional pid controller consists three hidden nodes act proportional integral derivative node gains mix locally recurrent neural network based pid mlrnnpid controller scheme initialized newly developed cuckoo search algorithm csa based optimization method rather assuming randomly sequential learning based least square algorithm investigated online adaptation gains mlrnnpid controller performance proposed controller scheme tested plant parameters uncertainties external disturbances links two link robotic manipulator variable payload rmwvp stability proposed controller analyzed using lyapunov stability criteria performance comparison carried among mlrnnpid controller csa optimized nnpid optnnpid controller csa optimized conventional pid optpid controller order establish effectiveness mlrnnpid controller isa published elsevier ltd rights reserved
beliefs problem solving connected studied different contexts one common results previous research students tend prefer algorithmic approaches mathematical tasks study explores swedish upper secondary school students beliefs reasoning solving non routine tasks results regarding beliefs indicated students found deductively include expectations motivational beliefs security comes reasoning variety approaches found even though tasks designed demand imitation algorithms students used method failed solve task
beliefs surrounding practice eating animals widely held argued constitute ideology named carnism joy developed validated novel carnism inventory measure two positively related components carnistic beliefs carnistic defense carnistic domination anticipated carnistic defense would legitimate practice eating animals carnistic domination would support killing animals meat carnism inventory showed hypothesized two dimensional structure well good internal consistencies stability study also demonstrated convergent discriminant validity carnism inventory study expected carnistic defense predicted meat consumption carnistic domination significant predictor slaughtered animal study scales significantly related sociopolitical beliefs including right wing authoritarianism social dominance orientation carnistic domination related symbolic racism sexism study taken together findings highlight utility two dimensional conceptualization measurement carnistic beliefs offer new insights one common human behaviors eating animals gustatory behavior widely believed also ideological one elsevier ltd rights reserved
million people attempt suicide every year worldwide suicide attempts represent major economic burden suicide attempters suffer high rates comorbidity comorbidity rule suicide attempters comorbidity complicates treatment prognosis causes protracted course present narrative review included patterns comorbidity intra axis disorders intra axis disorders axis axis disorders psychiatric physical illnesses also briefly reviewed patterns comorbidity suicide attempters concluded comorbidity different levels appears rule suicide attempters particularly attempt however several issues deserve research regarding patterns comorbidity suicide attempters
riverbank ottawa river protected erosion using rounded granular material glaciofluvial origin local gravel pits method require slope reprofiling installation key geotextile allows slopes structure banks reach equilibrium state relies natural vegetation regrowth banks embankments rather bioengineering revegetation techniques follow done assess effectiveness fifteen years structures halted erosion blended local landscape created riparian ecotone quickly acquired natural gently sloping profile recreated sinuous shoreline dotted sandy beaches follow also shows banks structures covered indigenous vegetation furthermore vegetation diverse natural vegetation seen unstabilized sections riverbank work minimized damage riverbanks done winter shore ice could used access approach helped avoid interventions banks protected existing vegetation availability granular sources near work site key criterion riverbank protection work scale uncommon article discusses effectiveness protection method environmental advantages limitations method could prove alternative traditional rock fill methods bioengineering techniques often quite complex costly elsevier rights reserved
bus rapid transit system brts india increased implementation two cities eight cities significant increase total ridership paper attempts give detailed review brts implementation cities india systematic effort could inform readers current system network characteristics indian brts different system corridor characteristics including board board ticketing systems adopted india gross cost revenue collection model adopted almost special purpose vehicle spv companies developed manage brt systems variety carriageway concept designs brts implemented cities considering right way meters respectively eight cities ahmedabad almost total fleet size terms regulatory context spv companies formed almost eight cities observing ahmedabad brt success documentation operating systems shall provide sound database planners decision makers actively involved brt system implementation developing countries
may june equipped barren ground grizzly bears ursus arctos satellite radio collars within study area centred northeast yellowknife northwest territories estimated annual ranges radio tracked animals greater equal locations years using fixed kernel technique least squares cross validation annual ranges males bar larger ranges females bar ranges increased size proportional amount exposed bedrock marginal habitats environment increased annual ranges largest reported grizzly bears north america
bhakri indian unleavened white flat bread prepared sorghum largely consumed economically poor sections country present study efforts made standardize optimise measure glycaemic index bhakri different legume flours green gram black gram soybean chick pea fenugreek seed added bhakri proportion ranging bhakri flours addition received highest sensory score selected analysis determined vitro enzymatic method control bhakri showed whereas addition chickpea flour significantly lowered bhakri bhakri soft palatable low
bicmos bandgap reference bgr advantage mos based bgr terms accuracy reference output less temperature coefficient paper presents bandgap reference circuit folded cascode operational amplifier amp order improve stability final ref output temperature stability output improved using trimming circuit voltage mode architecture bandgap reference operating less power consumption using first order temperature compensation technique proposed circuit gives output voltage degrees degrees temperature variations corresponds ppm degrees output reference voltage exhibits line variations supply range typical process corner single stage folded cascode amp included proposed bandgap improves stability output voltage closed loop power supply rejection ratio psrr bgr input common mode range proposed circuit includes start circuit avoid start problem closed loop reference current amp generated bgr current mirror impact final ref negligible simulation results shows psrr proposed bgr khz frequency phase margin degrees input offset amp closed loop gain amp bgr total current overall bgr total power consumption proposed bandgap reference simulated using mentor graphics pyxis tool eldo spice simulator cmos technology proposed bgr output used low drop ldo regulator circuit operating supply gives regulated output
bidirectional associations sibling relationships children problem behaviors robust links prosocial behavior also reported using cross lagged models able conservatively test temporal directions links positive negative aspects sibling relationships children prosocial behavior conduct problems across year time span middle childhood avon longitudinal study parents children alspac http www bristol alspac researchers data access data dictionary ongoing population based study designed investigate effects wide range factors children health development purposes current analyses included alspac families older sibling well target child age gap years mothers reported quality sibling relationship children prosocial behavior conduct problems target child years age target child years old confirming hypothesis individual child behavior predictive sibling relationship quality sibling relationship quality predictive later child behavior providing robust evidence bidirectionality prosocial behavior conduct problems would consistent expect improvement either sibling relationship quality individual children behavior could positive spill effect also found evidence older sibling dominance domain prosocial behavior positive aspects sibling interaction
bidirectional reflectance distribution function brdf estimation one fundamental problems computer graphics computer vision related fields yet work relies conventional local minimisation two global optimisation methods estimating anisotropic ward brdf model variants cost function introduced presented algorithms based branch bound search guarantees provide globally optimal solutions contrast traditional local optimisation methods mentioned affected setting initial brdf parameter values experiments carried validate presented methods using anisotropic materials utia brdf database
big data deals enormous volumes complex exponentially growing data sets multiple sources rapid growth technology able generate immense amount data almost field imaginable including physical biological biomedical sciences diversity amount data health care industry increasing need evaluate components big data frameworks gauge adaptability analytics techniques however key step adapting big data tools portability relational databases big data environment since sql considered facto language interactive queries paper evaluate performance sql like big data solutions portability existing relational databases work focuses benchmarking multiple sql like big data technologies hadoop based distributed file system hdfs study data tabulation model sdtm used clinical trial databases improving efficiency research clinical trials use publically available clinical trial data national institute drug abuse nida follows sdtm test bed measure key parameters like usability adaptability modularity robustness efficiency solutions intention demonstrate current clinical trial functionality replicated big data backend high sql like functionality evaluate several types hoc sql queries
bill reynolds remarkably creative scientist combined natural curiosity enormous energy make significant contributions fluid mechanics research article combine recollections many others capture aspects bill personality sense humor made irrepressible person discuss works turbulent flow touch others illustrate wide range interests survey involvement education classroom teaching mentoring research students lifelong support division fluid dynamics american physical society cover many contributions long career stanford university spent entire working life especially seminal role center turbulence research
binary space partitioning bsp one successful method acceleration ray tracing computer graphics bsp applied ray tracing coupled geometrical optics modeling wireless propagation performance acceleration bsp investigated result accelerated bsp compared full wave electromagnetic simulating method finite difference time domain fdtd
bioflavonoids utilised neuroprotectants treatment various neurological disorders including alzheimer disease astilbin bioflavanoid reported potent neuroprotective effects preventive effects amyloid beta beta induced alzheimer disease related cognitive impairment underlying mechanisms effects well characterised five month old appswe psde transgenic mice randomly assigned vehicle group two astilbin either per day intraperitoneally groups weeks treatment observed beneficial effects astilbin per day including lessening learning memory deficits reducing plaque burden beta levels furthermore expressions camp responsive element binding protein creb brain derived neurotrophic factor bdnf significantly increased disturbance akt gsk beta signalling pathway markedly ameliorated hippocampus astilbin treated per day group data suggest astilbin might potential therapeutic agent
biogenic amines nitrogen compounds products decarboxylation free amino acids produced participation bacterial microflora producing enzymes may introduced together food human body highest amounts biogenic amines found meat fish cheeses consumption products containing biogenic amines cause food poisoning allergies consumers common amines cheeses tyramine histamine putrescine cadaverine phenylethylamine formation amines depends technology food production storage conditions temperature time moisture quality raw materials content free amino acids proteins salts sugars presence microorganisms producing decarboxylases article describes different types biogenic amines formation detection methods health risks consumers information harmfulness biogenic amines factors conducive production may help prevent poisoning compounds
bioluminescence imaging transgenic mice expressing firefly luciferase doublecortin dcx neuroblasts might serve powerful tool study role neurogenesis models brain injury neurodegeneration using non invasive longitudinal vivo imaging therefore aimed use bli tyrc dcx luc doublecortin luciferase dcx luc mice investigate suitability assess neurogenesis unilateral injection model parkinson disease aimed assess blood brain barrier leakage associated intranigral ohda injection evaluate impact substrate delivery bioluminescence signal intensity two weeks lesion observed increase bioluminescence signal ipsilateral hippocampal region ohda vehicle injected dcx luc mice time corresponding increase dcx neuroblast numbers could observed dentate gyrus cbl mice blood brain barrier leakage observed hippocampal region degenerating substantia nigra cbl mice vivo using weighted magnetic resonance imaging gadovist vivo using evans blue fluorescence reflectance imaging mouse immunoglobulin staining data suggests bli signal dependency blood brain barrier permeability underlining major pitfall substrate tracer dependent imaging invasive disease models
bioremediation plays important role oil spill management bio electrochemical treatment systems supposed represent new technology effective remediation energy recovery diesel removal rate increased four times microbial fuel cells mfcs since electrode served electron acceptor high power density current density achieved using diesel sole substrate revealed scanning electron microscope images carbon fibres anode electrode covered biofilm bacterial colloids build link carbon fibres enhance electron transmission trace metabolites produced anaerobic biodegradation identified gas chromatography mass spectrometry metabolites may act emulsifying agents benefit oil dispersion play vital role bioremediation oil spills field applications elsevier ltd rights reserved
bipolar disorder associated periodic symptom exacerbations leading functional impairment increased risk suicide although clozapine never approved treatment occasionally used severe mania aim study evaluate risks benefits switching clozapine remitted patients observational mirror image study consecutive remitted outpatients treated clozapine twenty five patients switched another antipsychotic following change drug reimbursement rule continued clozapine mean time remission shorter switched group months months number patients relapsed larger results suggest switching clozapine another antipsychotic may increase risk relapses remitted patients
bipolar disorder recurrent highly incapacitating illness related inflammation changes insulin like growth factor igf objective study evaluate serum levels igf bipolar disorder patients relation inflammation included patients bipolar disorder healthy controls serum concentrations igf growth hormone insulin tumor necrosis factor tnf alpha analyzed serum levels igf seem increased bipolar disorder patients compared controls comparing reference values igf serum concentrations groups found patients increased igf serum concentrations subjects normal range find statistically significant differences groups concentration insulin tnf alpha study suggests association igf pathophysiology bipolar disorder possible peripheral increase related central nervous system increased resistance igf thus reducing neuroprotective action
bipolar disorder characterized sleep dysregulation suggesting role reticular activating system ras postmortem studies showed increased expression neuronal calcium sensor protein ncs brains bipolar disorder patients reduced aberrant gamma band activity present disorder lithium shown effectively treat mood disturbances bipolar disorder patients previously showed ncs low levels increased high levels decreased gamma oscillations ras pedunculopontine neurons ppn decreased oscillations previously described effects agent oscillations protein mechanisms currents however designed present experiments determine nature interaction ncs physiological concentrations would effect within minutes application expected decreased gamma oscillation amplitude ncs increased amplitude gamma oscillations identified ncs mol concentration increased gamma oscillations within min mol concentration decreased gamma oscillations within min combined application ncs concentrations showed reduced effects ncs oscillation amplitude within min results demonstrate physiological levels acts reduce effects ncs given expression ncs would salutary effects
bisphenol bpa endocrine disrupting chemical edc prevalent many household items rodent models human epidemiological studies linked chemical neurobehavior impairments california mice developmental exposure bpa results sociosexual disorders adulthood including communication biparental care deficits behaviors primarily regulated hypothalamus thus sought examine transcriptomic profile brain region juvenile male female california mice offspring exposed periconception lactation bpa ethinyl estradiol estrogen present birth control pills considered positive estrogen control bpa studies two weeks prior breeding females fed control diet diet supplemented bpa feed weight ppb continued diets lactation weaning brains male female offspring collected hypothalamic rna isolated rna seq analysis performed results indicate bpa groups clustered separately controls bpa exposure leading unique set signature gene profiles kcnd downregulated hypothalamus bpa exposed females whereas tbl topors kifa phactr upregulated groups comparison transcripts differentially expressed bpa groups revealed significant enrichment gene ontology terms associated microtubule based processes current results show perinatal exposure bpa result several transcriptomic alterations including associated microtubule functions hypothalamus california mice remains determined whether genes mediate bpa induced behavioral disruptions
blends ethylene propylene diene monomer epdm polyaniline pani doped dodecylbenzene sulfonic acid prepared mechanical mixing internal mixer various compositions times reflectivity characteristics blends ghz range investigated naval research laboratory arch method microwave absorption behavior affected processing time blend composition correlation reflectivity measurements morphology observations made scanning electron microscopy suggested distribution concentration pani phase within epdm matrix altered wave matter interactions radar absorbing materials prepared work showed broadband behavior microwave radiation absorption john wiley sons inc appl polym sci
body image primary school hutchinson calland body image curriculum widely available yet evaluated study evaluates set available lessons curriculum seventy four girls boys aged recruited four primary schools schools randomly allocated intervention condition students received hours body image lessons lessons normal body esteem significantly higher among girls intervention group compared control group immediately post intervention month follow moreover girls lowest levels body esteem baseline reported largest gains internalization significantly lower among boys control group compared intervention group month follow pattern results among control group raises interesting issues intervention evaluation published elsevier ltd
bond strength important factor electronic photonic packaging measuring bond characteristics strength fracture toughness particularly difficult microelectronic devices miniaturized bonds used wafer bonding dimensional integrated circuits since applying load directly bonds proven difficult four point bending test notched specimen typically used facilitate fracture toughness measurements small scale method based experiencing large peeling shear stresses interface two layers different materials notch however lack analytical solution used determine peeling shear stresses interface four point bend specimen manuscript presents analytical modeling peeling shear stresses tri layer four point bend specimens strength materials approach assumption small strains within elastic region adopted study evaluation stresses displacements furthermore beam theory utilized develop equations describe moments shear forces assembly due four point bending loads second fourth order differential equations derived shear peeling stresses respectively interfaces assembly boundary conditions determined based load supports shear force moment diagrams assembly problem solution obtained solving governing differential equations instantaneously using standard methods finite element based simulation used compare verify analytical solution work also presents alternative approach stresses notch used determine fracture toughness experiment conducted specimen inter metallic material bond material analytical approach verified results four point bending experiment validated using conventional technique based energy equilibrium presented elsevier ltd rights reserved
bone turnover markers assist fracture risk prediction management monitoring osteoporosis patients without chronic kidney disease ckd use ckd mineral bone disorder mbd limited many markers breakdown products renally excreted including commonly used well standardized procollagen type propeptide terminal cross linking telopeptide type collagen markers unaffected renal function bone specific alkaline phosphatase associated mortality fracture rate ckd subjects available several automated analysers used combination pth bone specific alkaline phosphatase bone formation marker correlated well bone biopsy histomorphometry predicting adynamic bone disease tartrate resistant acid phosphatase resorption marker development automation high low bone turnover ckd mbd patients associated increased fracture mortality risk bone biopsy gold standard differentiate adynamic bone disease osteitis fibrosa limited availability cost appropriate use bone turnover markers vital decision commence anti resorptive agents monitor efficacy order avoid suppression bone turnover may lead stress fractures efforts required develop markers unaffected renal function standardized cut values fracture well vascular calcification end points
borderline personality disorder bpd shown valid reliable diagnosis adolescents associated decrease general social functioning evidence linking bpd adolescents poor prognosis important develop better understanding factors mechanisms contributing development bpd could potentially enhance knowledge facilitate design novel treatment programs interventions group paper outline theoretical model bpd adolescents linking original mentalization based theory bpd recent extensions theory focuses hypermentalizing epistemic trust provide clinical case vignettes illustrate extended theoretical model bpd furthermore suggest treatment approach bpd adolescents focuses reduction hypermentalizing epistemic mistrust conclude integration theory practice final section paper make recommendations future work area
borderline personality disorder bpd severe challenging treat mental disorder schema therapy individual therapy proven effective psychological treatment bpd group format gst developed evaluated randomized controlled trial united states piloted netherlands results suggest gst speeds amplifies treatment effects might reduce delivery costs however feasibility german health care system bpd patients high bpd severity comorbidity frequent hospitalization tested date investigated gst severely impaired highly comorbid female patients bpd needed frequent hospital admission patients received outpatient treatment program weekly group individual sessions year outcome measures including bpd severity general psychopathology psychosocial functioning quality life happiness schemas modes days hospitalization assessed start treatment months later semi structured interviews self report measures observed significant decreases severity bpd symptoms general symptom severity dysfunctional bpd specific modes schemas days hospitalization functional modes quality live happiness improved results feasibility study promising encourage implementation outpatient treatment programs even patients severe bpd high hospitalization risk however small sample size missing control group allow generalizability findings
air pollution meteorological factors metropolitan areas increased emergency department visits people chronic obstructive pulmonary disease copd studies investigated associations air pollution meteorological factors copd related health disorders asian countries study aimed investigate relationship environmental factors copd associated visits susceptible elderly population largest taiwanese metropolitan area taipei area including taipei city new taipei city data air pollutant concentrations meteorological factors daily temperature relative humidity air pressure daily copd associated visits collected taiwan environmental protection administration air monitoring stations central weather bureau stations taiwan national health insurance database taipei area used case crossover study design conditional logistic regression models odds ratios ors confidence intervals cis evaluating associations environmental factors copd associated visits analyses showed significantly greater lag effects lag days days copd associated visits elderly population years old warmer days significantly greater effect elderly copd associated visits estimated coexistence additionally either combined air pollutants increased risk elderly copd associated visits days high relative humidity air pressure difference respectively study showed joint effect urban air pollution meteorological factors contributed copd associated visits susceptible elderly population largest metropolitan area taiwan government authorities review existing air pollution policies strengthen health education propaganda ensure health susceptible elderly population elsevier ltd rights reserved
cognitive radio full duplex transmissions effective means enhance spectrum efficiency network capacity paper investigate problem power control underlay network nodes capable full duplex transmissions objective guarantee required quality service qos form minimum signal interference plus noise sinr ratio user keep interference primary users prescribed threshold design effective distributed power control scheme integrates proportional integral derivative pid controller power constraint mechanism achieve goals analyze stability performance proposed scheme develop hybrid scheme switch half duplex modes proposed scheme validated extensive simulations elsevier rights reserved
daily stress tendency react stress heightened levels negative affect stress sensitivity important vulnerability factors adverse mental health outcomes mindfulness based stress reduction mbsr may help reduce perceived daily stress stress sensitivity purpose study examine change perceived stress negative affect decoupling perceived stress evolved course mbsr program without making priori assumptions shape change seventy one adults general population participating mbsr provided daily diary assessments perceived stress mbsr time varying effect model tvem indicated perceived stress decreased linear fashion rather nonlinear fashion function time function cumulative number days mindfulness practice tvem multilevel growth modeling showed association perceived stress decrease course mbsr findings support hypothesis mbsr reduces also reduces extent individuals perceive days stressful also results suggest dose response relationship amount mindfulness practice reductions daily stress
finite element method cable numerical calculation limitations calculation main cable shape self anchored suspension bridge paper combined characteristics two methods worked cable shape internal force self anchored suspension bridge though iterative computation sanchaji bridge self anchored suspension bridge changsha city main cable shape calculated method calculating results show real shape main cable fit results well carefully calculate length girder compression influences unstressed length main cable position hangers calculating method adopted sanchaji bridge offered reference design construction similar bridges
boxing remains subject controversy often classified dangerous discussion based mostly retrospective studies survey conducted prospective study october september competitive boxers asked report injuries month questionnaire collected general information training competition recorded number bouts fought injuries resulting lost days total injuries recorded resulted interruption training competition boxer sustained injuries per year average injury rate injuries per training boxers fighting bouts per year sustain injuries injury rate function age age injuries head upper limbs occur frequently common injuries soft tissue lacerations contusions head injuries neurological symptoms rarely occur boxing high injury rate comparable contact sports injuries minor injury frequency function whether boxer competes junior adult category athletes fighting many bouts per year greater risk injury
bradykinin induces inflammation rheumatoid arthritis resveratrol potent activator sirtl could modulate inflammation deacetylating histones transcription factors investigated mechanisms underlying induced cox expression modulated resveratrol sirtl human rheumatoid arthritis synovial fibroblasts rasfs found induced cox protein mrna expression associated pge synthesis promoter activity mediated receptors attenuated selective antagonist hoel transfection sirna induced responses mediated pkc mapks kappa inhibited respective inhibitors sirnas regulation sirtl resveratrol suppressed induced cox pge production inhibiting interaction kappa cox promoter rasf induced cox pge expression mediated pkc dependent mapks kappa cascade resveratrol inhibited phosphorylation acetylation jun fos reduced binding cox promoter thereby attenuated cox expression therefore resveratrol may promising therapeutic intervention treatment inflammatory arthritis elsevier inc rights reserved
brand communities corporate social responsibility touted ability generate significant equity brands strong bonds among community members however reciprocal capacity brands mobilize followers engage prosocial behavior promising largely ignored researchers practitioners alike given untapped potential product aficionados said possess considerable knowledge expertise engagement lack research managerial guidance somewhat perplexing address shortcoming conducted longitudinal investigation two brand communities one non brand based product category community drawn five years data scientific crowdsourcing project aimed curing medical diseases alzheimer parkinson aids employing hazard modeling approach find contrary conventional wisdom brand community participation reduces likelihood joining participation non brand based product category community increases likelihood joining prosocial distributed computing project furthermore willingness help fellow community members plays important role likelihood join findings provide important insights firms seeking engage product category brand communities prosocial causes direct marketing educational foundation inc dba marketing edge rights reserved
brassinosteroids steroidal phytohormones significant role amelioration various stresses objective study determine effect foliar application epibrassinolide ebl growth quality perennial ryegrass lolium perenne tall fescue festuca arundinaceae schreb grown salt stress plants grown non saline saline conditions sprayed mgl ebl salt stress significantly reduced shoot growth turfgrass quality however ebl alleviated detrimental effects salt stress enhancing turfgrass quality increasing shoot growth clipping yield ebl application salt stress alleviated loss clipping yield reduced leaf firing weeks post application perennial ryegrass tall fescue respectively ebl may find additional use stress management turfgrass areas
bread wheat durum wheat strongly affected septoria tritici blotch caused hemibiotrophic fungus zymoseptoria tritici however tritici pathosystem well studied far compared compatible interactions tritici species cytological biochemical molecular levels fungal infection process investigations showed close spore germination leaf penetration features interactions although differences patterns events observed necrotrophic phase disease severity sporulation levels associated interactions increases two cell wall degrading enzyme activities endo beta xylanase endo beta glucanase well protease analysis plant defense responses first five days post inoculation revealed inductions gluc chi pox pal repression lox gene expressions wheat species although differences kinetics levels induction repression observed addition peroxidase catalase glucanase phenylalanine ammonia lyase lipoxygenase activities induced wheat species weak accumulations hydrogen peroxide polyphenols detected fungal penetration sites study revealed overall similarity tritici infection process triggered wheat defense pathways pathosystems
bread wheat one major staple foods worldwide population iron plays significant role growth development plant report presenting genome wide identification iron binding proteins bread wheat wheat genome derived putative proteome screened identification iron binding sequence motifs putative iron binding proteins able produce reliable structural models homology techniques analyzed presence iron binding structural motifs computationally identified proteins appear bind ferrous ferric ions showed diverse coordination geometries glu asp cys amino acid residues found mostly involved iron binding classified proteins basis localization different cellular compartments identified proteins classified protein folds families functional classes ranging structure maintenance cellular components regulation gene expression post translational modification membrane proteins enzymes signaling storage proteins comprehensive report regarding structural iron binding proteome provides useful insights diversity iron binding proteins wheat plants utilized study roles plant growth development physiology elsevier inc rights reserved
bright light blue green range administered early morning hours prior waking may particularly effective shifting circadian rhythms may increase gonadotropin production accordingly tested feasibility utility mask emits bright blue green light compared similar mask emitted dim red light towards end sleep randomized placebo controlled pilot study study included three day baseline period immediately followed day intervention period subjects healthy young men minimal mild depression bright light masks well tolerated demonstrated adequate safety feasibility following intervention wore bright light mask demonstrated altered sleep timing suggestive earlier sleep period excreted slight increase follicle stimulating hormone fsh overall light masks may prove useful future studies bright light therapy
bright light therapy blt considered among first line treatments seasonal affective disorder sad yet growing body literature supports use neuropsychiatric conditions including non seasonal depression despite evidence antidepressant efficacy clinical use blt remains highly variable internationally article explore autonomic effects blt suggest effects may play role antidepressant chronotherapeutic properties providing brief introduction clinical application blt review chronobiological effects blt depression autonomic nervous system depressed non depressed individuals emphasis non seasonal depression theory autonomic modulation via blt could serve integrate aspects recent work centered alleviating allostatic load polyvagal theory neurovisceral integration model emerging evidence roles glutamate gamma hydroxybutyric acid gaba
bright light therapy shown positive impact seasonal affective disorder sad depression anxiety smell also shown effects mood stress anxiety depression objective study investigate effect combination light smell non adaptive cycle human subjects given smell lemon lavender peppermint light stimuli triangular wave cycle min blood pressure heart rate monitored session consecutive days profile mood states poms test administered sensory stimulation days light smell stimulus lowered blood pressure systolic diastolic reduced heart rate odours compared control two sensory stimuli odour stimulus contributed effect different aromas light smell combinations could distinguished different effects mood factors lemon inducing greatest mood changes dejection depression anger hostility tension anxiety conclusion combined light smell stimulation effective lowering blood pressure reducing heart rate improving mood combination effective either smell light stimuli alone suggesting light smell combination would robust efficacious alternative treatment depression anxiety stress authors published elsevier inc
britain education act stimulated partial migration pupils special mainstream schools onus since teachers meet needs capitalise capabilities pupils special educational needs disabilities send mainstream school settings research analysed learning support assistant lsa special educational needs coordinator senco views inclusion physical education individual interviews conducted lsas sencos working mainstream schools north west england open axial selective coding performed interview transcripts identify reoccurring themes research found sencos lsas considered inclusive subject conceptualisation left however developing provision met needs optimised capabilities pupils autism spectrum disorders asd supporting pupils send team games competitive sports identified key challenges inclusion may concern educationalists given types curriculum activities recently repositioned heart england key challenge involved educating pupils send especially teachers lsas plan teach team games competitive sports ways meet needs stretch pupils particular asd
building strong therapeutic alliance patient utmost importance management psychocutaneous disease optimal management psychocutaneous disease includes pharmacotherapy psychotherapy article reviews psychotropic medications currently used psychocutaneous disease including antidepressants antipsychotics mood stabilizers anxiolytics discussion relevant dosing regimens adverse effects pruritus management addressed addition basic complex forms psychotherapy cognitive behavioral therapy habit reversal training described
building construction one largest final consumers environmental resources well one largest emitters greenhouse gas pollution paper aims propose ecological indicators green building construction applying slack based data envelop analysis approach resource conservation environmental protection incorporated conduct empirical analysis ecological indicators green building construction using china regional panel dataset use analysis discuss technological gaps across regions findings show half china provinces substantial potential increase ecological performance green building construction developed areas perform better developing areas iii five year plan period turning point china green building construction development policies green construction haye significant effects elsevier ltd rights reserved
building discriminative robust texture representation deal changes texture appearance fundamental issue texture classification local binary pattern lbp variants gain lot attention past decade achieve great success texture description however current existing lbp based features treat lbp local differential orientation gradient operator exploited local orientation pattern anisotropic structure information separately paper investigate theoretical scheme local differential approximation polar coordinate system order build new lbp based descriptor better takes account radial plus tangential components derivative information first present operator called circumferential derivative based tangential information different order derivatives present operator called radial derivative based radial information different order derivatives extract complementary information locally around central pixel new descriptor local binary circumferential radial derivative pattern crdp constructed fuse local circumferential radial derivative features based different orders well global feature based global difference central pixel intensity extensive experiments outex curet kth tips kth tips texture datasets indicate proposed crdp descriptor discriminative robust results obtained proposed crdp descriptor outperforms twenty recent lbp based state art methods including best reported results literature aforementioned texture datasets best knowledge elsevier ltd rights reserved
building information modeling bim technology provides broad ranging support aec architecture engineering construction industry needs inclusion web display provides increased support bim users desirable global cad computer aided design bim design software provide increased access building product specifications via web browser recent actions towards develop bim based webd environments evidence effort facing situation request integrate ifc industry foundation classes web technology webgl paper discusses method create visualization bim models web browser combining ifc standard webgl technology solution developed based upon conversion ifc text object file obj subsequent obj compilation webgl main work consists three parts first based ifc standard ifc obj transforming method constructed encoding specific ifc attributes obj file second webgl programming visualization method presented creating performance web browser thirdly visualization platform three layered structure designed based ifc webgl integration bim data testing approach platform suggested demonstrated consistency conversion process stability rendering quality display models web browser method may applied planning design workflows particularly multiuser multi bim application real time environments require bim models exported ifc files visualized easily web browser
building information modelling bim represents long term investment could allow time reduction cost enhancement means optimised design construction processes paper focuses first official italian public pilot project dealing implementation bim based validation construction optimisation construction process case study concerns residential building located dense urban district causing confined construction site affected space shortage coordination issues research aims implement interoperable ifc based process order support design construction phases performing advanced model code checking analysing construction phase bim architectural structural mep models enriched alphanumeric attributes required semi automatic validation processes auto matching bim objects construction activities also achieved early results showed possibility bim based semi automatic validation design choices improved coordination design disciplines moreover construction site simulation allowed comparison different layout options baseline schedules research also tested joint use model checking bim tools order analyse construction progresses exporting ifc based construction site configuration directly bim tool tested process created open interoperable multi disciplinary approach main findings concerning domestic special constraints described analysed elsevier rights reserved
building psychological research linking essentialist beliefs human differences prejudice test whether lay belief biological basis political ideology associated political intolerance social avoidance two studies american adults study study find belief biological basis political views associated greater intolerance social avoidance ideologically dissimilar others association substantively large robust demographic religious political control variables findings stand contrast theoretical expectations biological attributions political ideology associated tolerance conclude biological lay theories especially likely correlated prejudice political arena social identities tend salient linked intergroup competition animosity
building sustainability subject rational use green building systems techniques suitable combination systems techniques heart design parameters achieve user comfort health well environmental protection long term economic benefits designers must optimize combinations particular systems techniques imperative efficient design strategies achieving optimum solutions effectively leading complex process selecting system technique combinations integrated overall design goal optimize design effort research aims propose different methodologies help incorporate various green building systems techniques design process systems techniques prioritized relative weights may ease design process hence focus semi arid climatic conditions interviews conducted researchers building practitioners help express design priorities use priorities proposed design approach case study sustainable residential building validates workability design methodology consequently model proposed integration three sustainability dimensions design criteria building simulation programs facilitating realization green building design
buildings major consumers energy hong kong urban areas world building environmental assessment schemes green building rating tools gbrts adopted architects engineers researchers years help promote sustainable construction activities rating tool highlights energy use significant portion assessment provides guidance energy efficient strategies building energy efficiency usually improved passive active technologies active design involves making energy efficient heating ventilation air conditioning hvac systems hot water production lighting building services application whereas passive design focuses building envelope related aspects determined architectural design reduce demand building energy recently renewed interest passive strategies low extra investment potential benefits energy saving passive design approach also recognized latest versions green building rating tools five representative rating systems developed passive design criteria leading award credits subject comparative examinations respect comprehensiveness effectiveness accuracy criterion paper passive design criteria including building layout envelope thermophysics building geometry air tightness infiltration performance effects building energy consumption also comprehensively reviewed results show holistic design approach based passive energy saving strategies proves effective way reduce building energy budgets however consolidated weighting systems enable comparison different passive strategies incorporated green building rating tools based sensitivity parametric studies elsevier ltd rights reserved
buildings represent total primary energy consumption contribute approximately one third total greenhouse gas emissions green building standards certification systems include requirements new existing buildings however vast part existing building stock cities built limited consideration green design energy efficiency low carbon emissions yet refurbishment help reach national energy reduction goals decreasing environmental impact furthermore retrofitting existing buildings often cost effective building new facilities potential existing building achieve certification certain green standard defined work green potential depends heavily factors determined original design construction process paper present development method tool analysis determination existing buildings allowing quick evaluation single building comparison different buildings order understand potential limitations designers intervention planning authorities ways determining development plans retrofitting potential cities districts
buildings tend operate intended pronounced gap often exists measured predicted environmental energy performance although causes performance gap multi faceted issues surrounding data integration key contributory factors distributed nature architecture engineering construction aec industry presents many challenges effective capture integration assessment building performance data building data described semantically feasible create adapters many different software tools similarly building contextual data easily captured single product centric model paper presents new solution problem based upon hybrid architecture links data retained original format architecture links existing efficient relational databases storing time series data semantically described building contextual data main contribution work original rdf syntax structure ontology represent existing database schema information new mechanism automatically prepares data streams processing rule based performance definitions two test cases evaluate concept applying hybrid architecture building performance data actual building evaluating efficiency architecture purely rdf based solution also stores time series data rdf virtual building hybrid architecture also avoids duplication time series data overcomes differences found database schemas database platforms published elsevier
bulk strain solitons solids attract considerable attention applications due small decay permanent bell shape wave parameter dependence waveguide elasticity geometry one reasons evident gap theory numerical simulation strain solitons propagation various waveguides comparatively rare experimental verification rigorous results lies extensive variability physical constants data available polymers show dramatic improvement experimental setup provides new opportunities solitary wave observation parameters measurements digital holography based high speed registration cameras allowed refine accuracy measurements precise pulse synchronization provided direct measurements bulk strain soliton velocity proper accuracy confirms fact soliton parameters depend rather waveguide geometry material initial pulse power provides either single soliton soliton train elsevier rights reserved
bundelkhand region central india hot spot water scarcity land degradation poverty poor socio economic status impacts integrated watershed development iwd interventions water balance different ecosystem services analyzed one selected watershed bundelkhand region improved soil water crop management interventions garhkundar dabar gkd watershed bundelkhand region india enhanced compared untreated control watershed receiving annual average rainfall reduced storm flow along increased base flow groundwater recharge total rainfall received recorded treated watershed compared untreated control watershed economic water productivity total income increased inr inr implementing integrated watershed development interventions gkd watershed respectively moreover iwd interventions helped reducing soil loss compared control watershed results demonstrated integrated watershed management practices addressed issues poverty watershed benefit cost ratio project interventions found three pay back period within four years suggest economic feasibility scale iwd interventions bundelkhend region scaling integrated watershed management drought prone rainfed areas enabling policy institutional support expected promote equity livelihood along strengthening various ecosystem services however region specific analysis needed assess trade offs downstream areas along onsite impact elsevier rights reserved
burgeoning online environments offer completely new opportunities ethnographic forms qualitative research yet clear standards study online texts ethnographic perspective article identify barriers application traditional qualitative methods online using example systematic thematic analysis weight loss blogs barriers include influence technology structuring online content fluid nature online texts blogs highly connected public nature online identities may span multiple social media platforms discuss potential approaches addressing challenges preliminary steps toward developing tool kit suited ethical high quality online modes ethnographic research
considering loaded empty moving tie robots moving among loading station machines unloading station flexible robotic manufacturing cell scheduling problem multiple robots studied improved discrete particle swarm optimisation genetic operator random heuristic initialisation method created minimise makespan addition multi robot scheduling strategy proposed minimise displacement operation inserting transportation tasks exchanging positions critical operations neighbourhood structure established enhance capacity algorithm local search detailed algorithm design description report results computational study provides evidence proposed optimisation based approach delivers high quality solutions well known algorithms
exchanging information directly non adjacent protocol layers cross layer interaction significantly improve optimize network performances energy efficiency delay particularly important wireless sensor networks wsns sensor devices energy constrained deployed real time monitoring applications existing schemes mainly exploit information exchange physical medium access control mac routing layers handful involving application layer first time proposed framework optimization based user context ambient intelligence ami application ontology based context modeling reasoning mechanism applied proposed framework jointly optimize mac network net layer protocols wsns extensive evaluations show resulting optimization context awareness interaction mac net layer protocols yield substantial improvements terms throughput packet delivery delay energy performances
means symbolic computation darboux transformation analytically numerically investigated paper two coupled sasa satsuma system describe pulse propagation birefringent fibers increase bit rate optical fibers achieve wavelength division multiplexing analytical bright soliton solution system firstly derived based bright one two soliton solutions numerical simulation figure illustration carried multi parametric management different choices among eight parameters two soliton solutions interaction mechanisms bright two solitons revealed three aspects separating evolution behaviors elastic collision behaviors inelastic collision behaviors exist three different cases inelastic collision two soliton reflect correspondingly different energy transfer mechanisms intensity redistribution two components manakov typed collision near elastic collision another completely inelastic collision two components four single solitons two components undergo shape changes inelastic elastic due intensity redistribution one single soliton keeps invariant three single solitons change collision collision mechanisms may viewed two solitons interact waveguide supporting propagation two nonlinear waves simultaneously general partial suppression enhancement intensity components dependent values soliton parameters elsevier rights reserved
use thermodynamics formalism irreversible processes complex systems theory systems biology derived relationship production entropy per unit time fractal dimension tumor growth rate human tumors cells thermodynamics framework developed demonstrates dissipation function landau potential also lyapunov function dynamical behavior tumor growth indicate directional character stability robustness phenomenon entropy production rate may used quantitative index metastatic potential tumors current theoretical framework hopefully provide better understanding cancer contribute improvements cancer treatment elsevier rights reserved
using ghz like states entanglement swapping kang chin phys proposed controlled mutual quantum entity authentication protocol find proposed protocol secure center charlie eavesdrop secret keys shared alice bob without detected
inhibitor deficiency rare disorder manifesting recurrent attacks disabling potentially life threatening angioedema present updated united kingdom consensus document management inhibitor deficient patients representing joint venture united kingdom primary immunodeficiency network hereditary angioedema develop consensus assembled multi disciplinary steering group clinicians nurses patient representative steering group first met developing total recommendations across themes statements distributed relevant clinicians representative group patients scored agreement likert scale statements achieved high degree consensus indicating strong alignment opinion recommendations evolved significantly since document particularly notable developments including improved evidence base guide dosing indications acute treatment greater emphasis home therapy acute attacks strong focus service organization
cad modelers enable designers construct complex shapes high level rep operators avoids burden low level geometric manipulations however gap still exists shape designers mind way decompose sequence modeling steps bridge gap variational modeling enables designers specify constraints shape must respect constraints converted explicit system mathematical equations potentially inequalities modeler numerically solves however available programs sketchers basically higher dimension constraints may complex mathematical expressions paper introduces new approach sketch constrained shapes main idea replace explicit systems mathematical equations mainly computer graphics routines considered black box constraints obvious difficulty arguments routines must known numerical values paper shows solve issue solve optimize without equations feasibility promises approach illustrated developed deco deformation constraints prototype elsevier ltd rights reserved
cadmium one toxic metals widely distributed freshwater marine environments received much attention toxicological perspective aim study assess effect peacock blenny salaria pavo species family blennies used bioindicator water pollution performed sublethal contamination fish cdcl days accumulation measured gills liver displayed significant increase concentration throughout experiment slightly higher levels liver except days partial length cdna mnsod cuznsod cat gpx characterized results mrna expression levels displayed regulation mnsod biomarker activities determined gills liver gills data displayed inhibition erod gst activities exposure significantly increased gpx activities affect cat levels throughout experiment lpo induction observed gills exposed fish regarding liver activity enzymes mda levels increased significantly beginning experiment except erod increased days contamination histological level fish exhibited pathological symptoms gills liver predominance circulatory disturbances gills regressive changes liver results displayed peacock blennies able survive toxicity due various physiological adaptation mechanisms
calcium bioavailability two types enriched calcium citrate calcium carbonate milks homogenized nano sized particle distribution studied among female sprauge dawley rats skim milk powder enriched essential nutrients inulin dha epa vitamins enhancers calcium bioavailability according recommended dietary allowances west european north american ovariectomized ovariectomized osteoporosis rats used menopause menopause osteoporosis model respectively although nano sized enriched milk powders greatest calcium bioavailability among groups bioavailability nano sized calcium carbonate enriched milk significantly better nano sized calcium citrate enriched milk moreover trends similar bone calcium strength morphology therefore based current results calcium carbonate nano sized enriched milk could effective enriched milk powder ovariectomized osteoporosis ovariectomized rats model menopause osteoporosis menopause women elsevier ltd rights reserved
camera motion estimation observed scene features important task image processing increase accuracy many methods optical flow structure motion due curved geometry state space nonlinear relation observed optical flow many recent filtering approaches use first order approximation assume gaussian posteriori distribution restrict state euclidean geometry physical model usually also limited uniform motions propose second order optimal minimum energy filter copes full geometry well nonlinear dependencies state space observations results recursive description optimal state corresponding second order operator derived filter enables reconstructing motions correctly synthetic real scenes kitti benchmark experiments confirm derived minimum energy filter higher order state differential equation copes higher order kinematics also able minimize model noise also show proposed filter superior state art extended kalman filters lie groups case linear observations method reaches accuracy modern visual odometry methods
campus fraternity homes long associated party houses ample alcohol sexual activity development party culture universities fraternities associated high levels alcohol use alcohol consumption commonly cited risk factor perpetration victimization sexual violence review examines party culture applied campus climate traditional gender roles rape culture focus fraternity organizations fraternities risk protective factor discussed review discusses prevention program techniques varying success fraternity brothers offers suggestions future research prevention programs
positivity bias observed across various social network sites snss predict use prosocial lies sns facebook positivity bias may product politeness norms positive face concern influenced communication phenomena sites existed addition positive face concern may also affected unconscious cues primes promote prosocial behavior facebook conducted online experiment using current facebook users examine positive face concern surveillance primes affect prosocial lying public private facebook contexts although positive face concern publicness predicted use prosocial lying positive face concern affected publicness surveillance primes affect positive face concern use prosocial lies study hints towards nuance positive face concern potential limitations surveillance primes prosocial lying behavior elsevier ltd rights reserved
capacitor current feedback active damping extensively used grid connected converters lcl filter however systems tends become unstable digital control delay taken account especially low switching frequencies paper discusses issue deriving discrete model digital control delay presenting stable region active damping loop high low switching frequencies order overcome disadvantage capacitor current feedback active damping paper proposes modified approach using grid current converter current feedback expand stable region provide sufficient active damping whether high low switching frequencies applying modified approach active damping loop simplified fourth order second order design grid current loop simplified modified approach work well grid impedance varies active damping performance dynamic performance current loop verified simulations experimental results
cardiovascular risk factors aging dementia caide finnish population based study cognitively normal women self reported hormone therapy data use use years information type available prescription register cognition assessed longterm years use especially use estradiol alone among women hysterectomy bilateral oophorectomy associated better episodic memory although strong evidence protective effect estradiol cognition observed study improved global cognition among long term users suggests long term postmenopausal may beneficial cognitive domains
case files cook county medical examiner office reviewed analyze homicides due physical child abuse children years old fatal cases mostly involved younger subjects intracranial injuries leading cause death death due extracranial injuries uncommon eyes involved cases spinal cord involved cases mostly thoracic area cases previous injuries present significant differences pattern injuries age groups subjects showing signs impact head subjects evidence impact showed significant difference internal injuries association multiple injuries highly suggestive child abuse suspected child abuse postmortem examination including neuropathological ophthalmological radiological information always evaluated together investigative reports medical history
case reporta male domestic short hair cat presented chronic weight loss lethargy hyporexia complete haematological examination revealed non regenerative anaemia neutropenia thrombocytopenia well howell jolly bodies anisocytosis polychromasia macrocytosis blood smear evaluation histopathological evaluation bone marrow biopsy disclosed hypocellularity consistent bone marrow failure concurrent hypocobalaminaemia identified treated parenteral cyanocobalamin supplementation differential diagnoses pancytopenia including infectious toxic immune mediated neoplastic causes ruled conclusionthe cat erythrocyte leucocyte platelet counts normalised months cyanocobalamin supplementation suggesting pancytopenia may rare manifestation feline cobalamin deficiency
case year old man hospitalized schizophrenia psychiatric hospital drank hot water estimated degrees eight hours injury laryngopharynx edema gradually progressed breathing deteriorated upon arrival emergency room secured respiratory tract nasal intubation bronchoscope outcome edema gradually improved peaking hospital day extubated hospital day apparent respiratory esophageal problems discharged back psychiatric hospital day conclusion types laryngopharynx burns caused ingesting hot foods drinks rarely reported adults cases adults patient special situation psychiatric disorder necessary assume laryngopharynx burns might aggravated
catheter ablation treatment arrhythmia associated significant complications often repeated procedures consequently less invasive efficient technique required high intensity focused ultrasound hifu enables generation precise thermal ablations deep seated tissues without harming tissues propagation path potential used new ablation technique system capable delivering hifu heart transesophageal route using ultrasound imaging guidance developed tested vivo six male pigs hifu exposures performed atria ventricles time autopsy visual inspection identified thermal lesions targeted areas three animals lesions confirmed histologic analysis mean size esophageal thermal injury observed one animal presented bradycardia due atrio ventricular block provides real time confirmation interaction hifu electrical circuits heart thus guided hifu potential minimally invasively create myocardial lesions without intra cardiac device mail francis bessiere inserm world federation ultrasound medicine biology
catheter radiofrequency ablation rfa effective treatment symptomatic paroxysmal atrial fibrillation demonstrated multielectrode pulmonary vein ablation catheter pvac favourable outcomes months post ablation studies long term follow retrospectively reviewed consecutive pvac procedures centre november december rfa attempted patients symptomatic paroxysmal mean age years men ablation strategy consisted circumferential pulmonary vein isolation cpvi pvac system questionnaire used follow period assess efficacy ablation success defined freedom atrial flutter atrial arrhythmia period ranging months seventy seven patients included paroxysmal mean duration procedure min fluoroscopy time min time rfa min acute complication rate frequent vascular injury patients patient presented sepsis patient presented transient ischemic stroke single procedure mean months patients free symptomatic long term results suggest pvac efficient system cpvi symptomatic paroxysmal
glycosylphosphatidylinositol anchored glycoprotein negatively regulates tgf beta signaling originally identified hematopoietic tumors however significance hematopoietic malignancies remains unclear study association diffuse large cell lymphoma dlbcl prognosis eighty four dlbcl specimens immunohistochemically analyzed expression cases classified low high expression groups respectively expression associated overall survival using kaplan meier analysis log rank tests however significant association observed high expression low year survival moreover combination revised international prognostic index ipi ipi poor high associated poorer prognosis compared ipi poor alone assessed tgf beta signaling depleted nalm cells human lymphoblastic leukemia lymphoma cell line found prolonged smad phosphorylation compared control cells tgf beta stimulation suggesting attenuates tgf beta signaling human cell tumors results suggest putative biomarker identifying high risk group among dlbcl patients
centralised electricity systems integrated multitude small distributed generation clusters called nanogrids capable ensuring full utilisation renewable energy sources high flexibility efficiency improved reliability power grid due redudancy study small photovoltaic plants combined energy storage systems represent promising solution full exploitation renewable energies effective development electromobility purpose study two fold first deals nanogrid suitable small energetic clusters residential office buildings consisting photovoltaic arrays fuel cells electric vehicle charger stations loads proposes multifunctional full bridge llc resonant converter building block latter accepting large input output ranges suitable photovoltaic fuel cells energy conversion electric vehicle recharging stations applications available nanogrid proposed power system interconnected conventional grid voltage source converter description proposed nanogrid analyses performed core element converter building block
cephalopods employ chromomorphic skins rapid versatile active camouflage signalling effects achieved using dense networks pigmented muscle driven chromatophore cells neurally stimulated actuate affect local skin colouring allows cephalopods adopt numerous dynamic complex skin patterns commonly used blend environment communicate animals ultimate goal create artificial skin mimic pattern generation techniques could produce host novel compliant devices cloaking suits dynamic illuminated clothing paper presents design mathematical modelling analysis dynamic biomimetic pattern generation system using bioinspired artificial chromatophores artificial skin made electroactive dielectric elastomer soft planar actuating smart material show effective mimicking actuation biological chromatophores proposed system achieves dynamic pattern generation imposing simple local rules artificial chromatophore cells sense surroundings order manipulate actuation modelling sets artificial chromatophores linear arrays cells explore capability system generate variety dynamic pattern types show possible mimic patterning seen cephalopods passing cloud display complex dynamic patterning
ceramic matrix composites cmc continuous fiber reinforcements potential enable next generation high speed hypersonic vehicles significant improvements gas turbine engine performance due exhibited toughness subjected high mechanical loads extreme temperatures reinforced fiber composites rfc provide increased fracture toughness crack growth resistance strength though little known stochastic variation imperfections material effect material properties work tools developed quantifying anomalies within microstructure several scales detection characterization anomalous microstructure critical step linking production techniques properties well accurate material simulation property prediction integrated computation materials engineering icme rfc based components desired find statistical outliers number material characteristics fibers fiber coatings pores fiber orientation velocity velocity gradient developed examined anomalous behavior categorizing anomalous behavior cmc approached multivariate gaussian mixture modeling gaussian mixture employed estimate probability density function pdf features question anomalies classified likelihood belonging statistical normal behavior feature
ceramides cers major components outermost layer skin stratum corneum play crucial role permeability barrier functions alterations cer composition causing skin diseases compensated semisynthetic skin identical cers plants constitute new resources cer production contain glucosylceramides glucers major components glucers purified industrial waste plant materials apple pomace malus domestica wheat germs triticum coffee grounds coffea glucer contents per plant material forty five species glucers identified different sphingoid bases saturated monounsaturated hydroxy fatty acids glucose polar headgroup three main glucers hydrolyzed recombinant human glucocerebrosidase produce phyto cers studies showed rare expensive phyto cers obtained industrial food plant residues
cervical cancer common important public health problem adult women developing countries contrast cervical cancer incidence low saudi arabia high risk types human papilloma viruses hpv hpv significant risk factors cervical cancer hpv oncoprotein associated hpv etiology viral persistence epithelial transformation cell cycle protein inka plays important role pathophysiology cervical carcinomas aims study investigate expression hpv uterine cervical carcinomas qassim region saudi arabia relate results established clinicopathological prognostic parameters age patient educational level birth control methods number pregnancy smoking status degree histological differentiation clinical stage lymph node metastasis study included specimens uterine cervical squamous cell carcinomas diagnosed confirmed biopsy histopathological classification cervical tumors cases performed according international federation gynecology obstetrics figo immunohistochemical analysis hpv carried formalin fixed paraffin embedded sections cervical tissues using avidin biotin peroxidase method significant statistical correlation hpv expression cervical carcinoma nationality smoking status size tumor hpv oncoprotein expression normal lymphocytes endothelial cells tumor tissues adjacent normal cervical tissues suggest possibility hpv infection might spread organs blood circulation expression correlated high grade stage cervical scc hpv expression current study supports critical function hpv specific markers cervical carcinoma however potential usage hpv prognostic markers require detailed follow data larger group patients
change detection one important applications remote sensing technology challenging task due obvious variations radiometric value spectral signature limited capability utilizing spectral information paper improved sparse coding method change detection proposed intuition proposed method unchanged pixels different images well reconstructed joint dictionary corresponds knowledge unchanged pixels changed pixels first query image pair projected onto joint dictionary constitute knowledge unchanged pixels reconstruction error obtained discriminate changed unchanged pixels different images select proper thresholds determining changed regions automatic threshold selection strategy presented minimizing reconstruction errors changed pixels adequate experiments multispectral data tested experimental results compared state art methods prove superiority proposed method contributions proposed method summarized follows joint dictionary learning proposed explore intrinsic information different images change detection case change detection transformed sparse representation problem authors knowledge publications utilize joint learning dictionary change detection automatic threshold selection strategy presented minimizes reconstruction errors changed pixels without prior assumption spectral signature result threshold value provided proposed method adapt different data due characteristic joint dictionary learning proposed method makes prior assumption modeling handling spectral signature adapted different data
changes retrovirus acquisition transmission behaviors reported brazil concerning increase hiv infected individuals aged years sao paulo hiv htlv hiv htlv coinfections associated intravenous drug use failure detect htlv human cell lymphotropic virus types immunosuppression use highly active antiretroviral therapy haart negative results htlv serologic western blotting molecular real time pcr pol qpcr confirmatory assays reported whereas best sensitivity found inno lia lia study expand previous data analyzing group young patients median age years recently acquired hiv sexual contact majority haart naive comparing performances four htlv confirmatory assays lia qpcr pcr rflp tax confirmed htlv infection blood samples htlv htlv htlv htlv htlv lia qpcr pcr rflp sensitivities respectively associations htlv infection female gender age years detected results confirm low sensitivities molecular assays best performance lia detecting htlv patients hypothesize negative pcr results due presence defective provirus low proviral load circulating patients inconclusive coinciding seroconversion period corroborating associations obtained repeated exposure required htlv sexual transmission acquisition efficient male female
channel deepening may result channel incision river metamorphosis changing wide shallow channel narrow deep one first type channel change leads increased flow capacity channel lowering water stage associated given discharge rather lowering river bed used identify channel incision lowering minimum annual stage gauging stations typically used assess relative importance channel incision along river within particular region rivers polish carpathians incised twentieth century amount incision greater lower middle courses upper ones variability hydraulic importance channel incision increasing river size analysed comparing changes frequency valley floor inundation gauging stations located along seventh order dunajec river despite lower absolute amount channel incision upper river course incision increased channel conveyance reduced frequency valley floor inundation considerably lower course hydraulic effects channel incision depend also lateral stability incising river low energy rivers eastern part polish carpathians remained laterally stable channel incision resulted substantial lowering stages low flood discharges markedly smaller one high magnitude floods whereas velocity flows conveyed highly elevated floodplains decreased considerably high energy rivers western part polish carpathians alternation incision lateral channel migration led formation incised meander belts substantially lowered stages flood discharges increased velocity flows conveyed newly formed low lying floodplains elsevier rights reserved
character based video games allow one practice various kinds behaviors virtual environment allow one practice different kind person propose games alter self perceptions personal characteristics attitudes values broad consequences behavior multiwave longitudinal study adolescents examined extent play mature rated risk glorifying mrrg games associated increases alcohol use cigarette smoking aggression delinquency risky sex consequence effects personality attitudes affiliations indicative increased tolerance deviance participants selected random digit dial procedures followed years data analyzed linear mixed modeling assess change time structural equation modeling latent variables test hypothesized mediational processes among play video games playing mrrg games associated increases measures behavioral deviance mediational models support hypothesis effects part consequence effects gameplay sensation seeking rebelliousness attitudes toward deviant behavior oneself others affiliation deviant peers effects similar males females strongest reported heavy play mature rated games games involved protagonists represent nonnormative antisocial values sum current research supports perspective mrrg gameplay consequences deviant behavior broadly defined affecting personality attitudes values player
characterization hardness mass loss friction coefficient carried valve guides internal combustion engines manufactured powder metallurgy aim finding fulfill requirements internal combustion engine mass produced currently available brass casting valve guides used comparative parameter analyzed whether properties present homogeneous way piece lengthwise additional repressing process carried production line respect sintered guides evaluated therefore brinell vickers dry slip pin disk tests done order determine friction coefficient wear rate scanning electron microscopy sem metallographic analysis used study wear mechanism chemical composition guides effect repressing quantifying porosity clear pieces manufactured powder metallurgy process showed lower values mechanical tribological properties compared commercially available valve guides taken reference results company manufactures guides powder metallurgy make adjustments suggested parameters guide production line
characterization thermoelectric generators teg widely discussed equipment built perform analysis one method often used perform characterization constant temperature variable thermal power input maximum power point tracking mppt methods teg systems mostly tested steady state conditions different constant input temperatures however teg applications input temperature gradient changes exposing mppt variable tracking conditions example exhaust pipe hybrid vehicles intermittent operation internal combustion engine tegand mppt controller exposed cyclic temperature profile furthermore guidelines fast mppt must dynamic conditions work discussed paper temperature gradients teg integrated several applications evaluated results showed temperature variation degrees teg systems electrical characterization calcium manganese oxide teg performed steady state different input temperatures maximum temperature degrees using electrical data characterization oxide module solar array simulator emulated performas teg trapezoidal temperature profile different gradients used teg simulator evaluate dynamic mppt efficiency known perturb observe algorithm may difficulty accurately tracking rapidly changing conditions solve problem compromise must found magnitude increment sampling frequency control algorithm standard performance evaluated experimentally using different temperature gradients different mppt sampling frequencies efficiency values provided cases results showed tracking speed successfully implemented teg system provide similar mppt efficiency input temperature changing degrees
chemical enzymatic barriers gastrointestinal tract hamper oral delivery many labile drugs epithelium also contributes poor permeability numerous drugs drugs poor aqueous solubility difficulty dissolving tract resulting low bioavailability nanomedicine provides opportunity improve delivery efficiency orally administered drugs solid lipid nanoparticles slns categorized new generation lipid nanoparticles consisting complete solid lipid matrix slns used oral administration offer several benefits conventional formulations including increased solubility enhanced stability improved epithelium permeability bioavailability prolonged half life tissue targeting minimal side effects nontoxic excipients sophisticated material engineering slns tailor controllable physicochemical properties nanoparticles penetration via mucosal lymphatic transport review highlight recent progress development slns disease treatment recent application oral slns includes therapies cancers central nervous system related disorders cardiovascular related diseases infection diabetes osteoporosis addition drugs may active cargos slns natural compounds pharmacological activity also suitable sln encapsulation enhance oral bioavailability article systematically introduce concepts amelioration mechanisms nanomedical techniques drug natural compound loaded slns copyright food drug administration taiwan published elsevier taiwan llc
chemoheterotrophic denitrification technologies using woodchips solid carbon source wood chip bioreactors widely trialed treatment diffuse source agricultural nitrogen pollution growing interest use simple relatively low cost biological wastewater treatment option waters relatively higher total suspended solids tss chemical oxygen demand cod aquaculture wastewater work evaluated hydraulic retention time hrt impacts cod tss removal assessed potential woodchip clogging wastewater chemistry four pilot scale woodchip denitrification bioreactors operated showed excellent tss removal occurred primarily near inlet cod removal maximized lower hrts removal efficiency cod removed per bioreactor per data hrt however influent wastewater took progressively longer move woodchips likely due combination woodchip settling clogging due removed wastewater solids accumulated bacterial growth pulsed flow system pushing chips away inlet bioreactor received highest loading rate experienced altered hydraulics statistically significant increases woodchip content time woodchip bags placed near bioreactor outlets along bioreactor floor confirmed wastewater solids removed may pose concern subsequent nutrient mineralization release nevertheless excellent nitrate nitrogen tss removal along notable cod removal indicated woodchip bioreactors viable water treatment technology types wastewaters given used downstream filtration device authors published elsevier ltd
chest computed tomography findings nodules ground glass opacities consolidations often interpreted representing invasive fungal infection individuals febrile neutropenia assessed whether findings present asymptomatic individuals acute myeloid leukemia aml low risk invasive fungal disease retrospective study consecutive asymptomatic adult patients newly diagnosed aml year period performed tertiary care oncology center radiology reports baseline chest cts reviewed scans majority pulmonary abnormalities many one unspecified opacities nodules ground glass opacities consolidations occurred less frequently radiologists suggested pneumonia possible diagnosis scans chest may result diagnosis invasive fungal disease individuals febrile neutropenia interpreted without correlation patients clinical status
child abuse neglect occur epidemic numbers united states around world resulting major physical mental health consequences abused children present future vast amount information available signs symptoms short long term consequences abuse limited number instruments empirically developed screen child abuse focused physical abuse context emergency department found minimally effective lacking rigor literature review focuses physical sexual psychological abuse neglect occurring one multiple forms polyabuse systematic depth analysis literature conducted literature review provides information identifying children abused neglected exposes need comprehensive screening instrument protocol capture forms child abuse neglect screening needs succinct user friendly amenable use children every point care healthcare system
child abuse major public health concern explain proportion fractures children osteogenesis imperfecta common inherited syndrome predisposes skeletal fractures conducted retrospective analysis data clinical laboratory radiographic information children evaluated child abuse molecular testing cola cola genes conducted total patients underwent molecular testing pathogenic variants predicted result mild form found two patients clinically suspected diagnosis none cases molecular testing ordered maltreatment concerns thought likely identified pathogenic variants reviewing individual case final diagnosis child abuse cases additional radiographic laboratory studies identify inherited metabolic predisposition fracture rickets conclude routine testing setting child abuse suggestive clinical findings present low yield careful review medical history detailed clinical evaluation help identify risk genetic alterations wiley periodicals inc
child adolescent abuse neglect children growing social problem limited medical legal social services professions dental professionals must able identify document report often help treat patients families study descriptive retrospective cross sectional design population consisting children adolescents treated forensic medicine cicpc merida venezuela period january june aim describing clinical findings dental interest child adolescent victims abuse information collected tab results presented tables graphs percentage bar findings showed physical injuries caused violent events usually unnoticed susceptible age group years wounds located lips frequent injuries present dental lesions required general dental treatment recommended promote research order know magnitude impact child adolescent abuse
child health literacy hot topic late researchers practitioners work attain equitable healthy future health literacy emphasizes wide range skills people need access understand evaluate use health information promote good health light recognition health literacy important determinant health adults addressing child health literacy early essential maximize future health outcomes meeting children specific needs arguably includes delivery information easily accessed understood younger age groups much academic discourse pertains importance building parental health literacy less literature explicitly focuses child centred health literacy premise health literacy asset paper provides argument investing children health literacy working children encourage meaningful contributions research practice
child protective services cps identifies victims child maltreatment united states annually research shows risk factors children may persist despite cps intervention mothers unique often untapped perspectives experiences consequences cps intervention may inform future practice explored perspectives interviews mothers first time cps finding maltreatment resulting home placement male partners primary perpetrators cases mothers sitters identified perpetrators remaining cases data analyzed using grounded theory mothers described risk factors roots maltreatment prior cps involvement reported variable experiences recognition response maltreatment divergent outcomes emerged feel stronger better findings provide understanding household experiences around child maltreatment may support practice policy changes improve outcomes vulnerable children
child sexual abuse csa causal agent many negative adulthood outcomes including risk life threatening behaviors suicide ideation suicide attempts traumatic events csa may pose risk healthy development cognitive emotional functioning childhood fact high impulsivity risk factor suicidal behavior characteristic csa victims current study aims understand relations among csa impulsivity frequency lifetime suicide attempts among female patient sample admitted suicidal behavior participants included female patients ages years admitted two hospitals buenos aires argentina number previous suicide attempts csa assessed via structured interviews impulsivity assessed barratt impulsiveness scale bis model structural equations employed evaluate role impulsivity relation csa suicide attempts csa beta impulsivity beta csa impulsivity independently associated lifetime suicide attempts among female patients recent suicidal behavior elsevier ltd rights reserved
child temperament well parenting behaviors linked adolescent depression beyond main effects interplay factors interest example interactive model differential susceptibility temperamental variants parenting suggested however far differential susceptibility hypothesis mostly studied focus externalizing disorders hand parenting may shape child temperament vice versa transactional process prospective longitudinal risk sample boys girls assessed emotional easy difficult regulative self control temperament ages years respectively well parenting quality age years using home inventory hierarchical linear regression analysis used investigate prediction depressive symptoms age measured child depression inventory including interaction terms temperament variable parenting additionally tested whether parenting mediated child temperament previously reported self control parenting longitudinally associated preadolescent depressive symptoms interactive effects temperament parenting however effects parenting partly mediated self control data support differential susceptibility temperamental variants development preadolescent depression however results line assumption parenting may shape young children temperament positive parenting early childhood fostering development regulative temperament
childhood trauma associated various forms emotion dysregulation including stress reactivity believed one mechanisms underlying link psychological disorders purpose present study line research using intensive longitudinal research design examine among college students women whether reports interpersonal specifically emotional abuse neglect uniquely moderate within person association repeated assessments daily stress negative affect stress reactivity study also examined whether link stress reactivity stronger discrete forms whether effects emotional abuse neglect unique trauma types distinct recent life stress neuroticism results indicated individuals severe histories emotional abuse showed stronger stress reactivity anxiety forms affect control variables introduced neglect also moderated association opposite direction extensive histories neglect exhibited lower anxiety response daily stress results highlight unique complex associations various forms interpersonal stress reactivity published elsevier ltd
children adults respond negatively inequity traditional accounts inequity aversion suggest children mature adults become less likely endorse forms inequity challenge idea children unified concern inequity simply becomes stronger age instead argue developmental trajectory inequity aversion depends whether inequity seen fair unfair three studies year olds likely year olds create inequity disadvantaged themselvesa fair type inequity findings consistent theory year olds likely year olds endorse advantageous inequity study inequity created third parties studies unfair types inequity discuss results expand recent accounts children developing concerns generosity partiality
children increased vulnerability many environmental contaminants compared adults due unique behavior patterns increased contaminant intake per body weight developing biological systems depending upon age young children may crawl floor may practice increased hand mouth activity may increase dose intake specific contaminants accumulate dust matrices children also smaller size adults resulting greater body burden given contaminant dose children undergo rapid transitions particular developmental stages also especially vulnerable certain growth related time windows special issue organized focused latest findings field children environmental exposure reasons editorial introduces articles special issue emphasizes main findings advancing field many articles submitted special issue around world accepted published focus variety research areas children activity patterns improved risk assessment methods estimate exposures exposures various contexts various contaminants future health nation relies protecting children adverse exposures understanding etiology childhood diseases field children environmental exposures must consider improved comprehensive research methods aimed introducing mitigation strategies locally nationally globally happy introduce special issue focused children environmental exposure children health hope contributes towards improved health children
children pre school age present limited cognitive development restricted vocabulary short attention span allow conducting classical taste sensitivity measures developed adults aim study develop validate age appropriate protocol sensitivity testing five basic tastes pre schoolers one hundred forty children aged years mean age months performed paired comparison task consisting discriminating water magic water relying affect order accommodate age group task gamified require verbal responses sweet sucrose ranging sour citric acid monohydrate umami monosodium glutamate salty sodium chloride bitter quinine hydrochloride dihydrate water dilutions tested four levels subsets children per taste participated retest sessions individual sensitivity scores derived two manners following experimenter success criterion water taste classified magic child criterion magic water children individual magic labelling strategies results show protocol highly engaging children performed task consistently children performances dependent cognitive level differences thus validating protocol study average children clearly sensitive sour stimuli selected dilutions equivalent across tastes different sensitivity distributions children obtained across taste modalities scoring criteria key elements age appropriate protocol pre schoolers discussed elsevier ltd rights reserved
children spend lot time parents first agents educate parenting style implemented family influences contexts outside home school evidence positive parenting style influence school success however variables related school success example temperament influence parenting decreases age children develop abilities self regulate without parents external control aim present study evaluate contribution parenting style temperament years old children academic performance school adjustment skills hypothesis parenting style crucial academic performance school adjustment also temperament plays important role used parenting guide line questionnaire evaluate parenting style early adolescence temperament questionnaire evaluate temperament health resources inventory assess children school adjustment academic grades indicator academic performance interested testing whether effect parenting style academic performance school adjustment mediated temperament found emotional behavioral regulationmediates relation parenting academic performance findings inform relevance child temperament school success implications education discussed emphasis importance understanding students temperament promote school adjustment good academic performance
children prosociality emerges early life suggests helping others rooted deeply human nature time motivation underlying young children instrumental helping poses puzzle children express specific emotion sympathy removing physical obstacles others instead motivated concern others well toddlers may act tie loose ends engage social interactions may motivated goals align others recent research addressed underlying motivation children helping directly measuring children internal arousal via changes dilation pupils several studies children arousal response others unfulfilled needs genuinely prosocial linked well others prosocial arousal may lie heart children instrumental helping also prosociality general
chili culinary well medical importance studies humans using wide range doses chili intake varying single meal continuous uptake weeks concluded facilitates weight loss regard main targets chili fat metabolism energy expenditure thermogenesis induce weight loss active substance chili capsaicin activates transient receptor potential cation channel sub family member trpv channels receptors causing increase intracellular calcium levels triggering sympathetic nervous system apart trpv chili directly reduces energy expenditure activating brown adipose tissue weight loss chili also result improved control insulin supports weight management positive effects treatment diseases like obesity diabetes cardiovascular disorders review summarizes major pathways chili contributes ameliorating parameters help weight management consumption chili help accelerating weight loss dietary modifications
china implemented national strategies major function oriented zones mfozs realize goal national sustainable development since study analyzed compared spatio temporal characteristics differences built area china mfozs using china land use database clud derived high resolution remotely sensed images periods sum percentage built area mfozs significantly different revealing gradient feature national land development based distribution main functions annual growth built area optimal development zones odzs decreased significantly compared period annual growth built area key development zones kdzs agricultural production zones apzs key ecological function zones kefzs increased significantly odzs average annual increase built area yangtze river delta region significantly higher regions average area increase rate increase built area kdzs faster western region regions average annual area growth built area apzs northeast central western regions twice high previous decade average annual rate change increase dynamic degree built area notable kefzs central region spatial pattern characteristics built area expansions period reflected gradient feature plan mfozs rate increase locally built area odzs apzs kefzs fast effective measures must adopted implementation national regional policies conclusions indicated methods results meaningful future regulation strategies optimizing national land development china
china suffered various water source pollution incidents past decades resulted severe threats safety water supply millions residents aspects quantity fluctuation temporal volatility regional inequality pollutant category variation accident type differences study first characterizes current status water source contaminations china analyzing pollution events period spanning results show general increase number accidents period rapid decline starting spring summer high incidence seasons pollution accident rate developed southeastern coastal areas far higher northwestern regions hazardous chemicals petroleum frequently occurring pollutants whereas heavy metals tailings becoming emerging contaminants occasional pollutions accidents occurred blamed illegal emissions traffic accidents however leakage production gradually become major accident type past decade combination government actions policy constraints paper explores deep inducements offers valuable insight measures taken ensure future prevention mitigation emergent source water pollution
china characterized low fertility intention strong preference sons well stringent birth control policy study used data fertility intention behavior survey questionnaires conducted shaanxi province northwestern china event history analysis methods examine effect fertility intention preference sons probability second child results validate correlation fertility intention second child empirically even low fertility intention stringent birth control context china also show women preference sons less likely second child women son preference turn sex selective abortion ensure first child son thus reducing likelihood second child decreasing fertility rate findings also shed light china potential fertility policy adjustment
china electronics industry seen significant development last decades electronics manufacturing industry become one country largest industries many well qualified researchers engineers needed meet demands microelectronics industry research fast developing electronics industry challenges conventional university education innovate education curriculum provide qualified engineers electronics industry challenging task universities education program microelectronic packaging assembly established guet paper experiences establishing multi level education program microelectronics manufacturing briefly summarized focus put new bachelor degree program microelectronic manufacturing engineering objective scope curriculum structure education program proposed emphasis sectors electronic packaging assembly test proposal supported fact existing huge demands qualified engineers sectors achieve goal core courses educational curriculum educational means proposed discussed effort enhance educational ability needed
china one child policy introduced late effect three decades article reviews china low fertility rate implementation stringent birth control policy context low fertility first china fertility intention behavior low fertility level trend presented official response low fertility level consequent misguided policy making investigated next various obstacles abolishment strict birth control policy discussed including national leaders authority related family planning regulations laws inertia basic state policy auspices common good displacement family planning systems necessity social maintenance fees keep grassroots governments operation discussing recent reform birth control policy subsequent results incentives universal two child policy elucidated include official acknowledgment low fertility effect birth control policy fertility decline reactions general public attitudes grassroots family planning cadres appeal scholars international experiences merging population family planning commissions national leaders attitudes paper concludes analysis cost birth control policy past decades
chinese herbal medicine chm plays significant role breast cancer treatment conduct study ascertain relative molecular targets effective chinese herbs treating stage breast cancer survival benefit chm verified kaplan meier method cox regression analysis bivariate correlation analysis used find establish effect herbs complex chm formulas network pharmacological approach adopted explore potential mechanisms chm patients chm group median survival time months longer months patients non chm group cox regression analysis indicated chm independent protective factor correlation analysis showed herbs strongly correlated favorable survival outcomes bioinformatics analyses suggested herbs might achieve anti breast cancer activity primarily inhibiting hsp alpha top related pathways
chitinases important disease related proteins play critical roles plant defense disease investigate function chitinases resistance hami melon penicillium infection gene encoding chitinases hmcht cloned rtpcr used measure expression levels hmcht hami melon infected penicillium results showed comparing control group time expression levels reaching peak delayed expression levels maintained significantly high level longer time results suggest hmcht may contribute defense hami melon fungal infection
choice control birthing women recently come global spotlight human rights issue likely remain midwives targetted providing home birth care focussing issues appears widen dichotomy medicine midwifery understanding divide maintained necessary move beyond article utilising foucault theory genealogy recapitulates midwifery knowledge came subjugated dominant medical discourse particularly process hospitalising birth submission australian medical association government enquiry maternity services examined illustrate discourse perpetuated medicine still configures dominant birth discourse australia importance focussing midwifery specific knowledge using notion embodiment put forward
cholangitis common felines including neutrophilic lymphocytic chronic cholangitis liver fluke history physical examination laboratory testing abdominal ultrasound support diagnosis diagnosis using hepatic histopathology bile analysis ideal always practical neutrophilic cholangitis associated bacterial cholecystitis pancreatitis inflammatory bowel disease typical presentation short illness lethargy inappetence pyrexia jaundice lymphocytic cholangitis suspected immune mediated prolonged clinical course weight loss ascites predominant features prevalence liver fluke infestation cats varies worldwide clinical manifestations uncommonly reported
choosing best sweetener green tea face big problem due several composition changes green tea registers sweetening process level gained toxicity different health level consumers especially diabetes cardiovascular digestive problems allergies additives management especially certain categories sweeteners food coloring preservatives big issue technologists also treating physicians adding sweeteners food coloring preservatives food products higher sensitive quality also higher risk potential consumers certain health problems obtained paper presents personal method determine best natural synthetic sweetener used without problems sweetening green tea free contamination area
chromophoric dissolved organic matter cdom riverine systems affected environmental conditions land use thus could provide important information regarding human activities surrounding landscapes optical properties water samples collected locations across liaohe river lhr china watershed examined using vis fluorescence spectroscopy determine cdom characteristics composition sources total nitrogen total phosphorus concentrations sampling sites exceeded national quality standards surface waters china standard class waters respectively trophic state index tsim indicated sites investigated mesotrophic eutrophic time redundancy analysis showed total suspended matter tsm dissolved organic carbon doc turbidity strong correlation cdom parameters chl tsim exhibited weak correlations cdom absorption high spectral slope values low suva specific absorption values indicated cdom lhr primarily comprised low molecular weight organic substances analysis excitation emission matrices contour plots showed cdom water samples collected upstream locations exhibited fulvic acid like characteristics whereas protein like substances likely predominant samples collected estuarine areas downstream large cities patterns interpreted indicative water pollution urban industrial activities several downstream sections lhr watershed
chronic benzodiazepine use common patients mental illness associated cognitive impairment unclear whether benzodiazepine induced cognitive impairment reversible amelioration cognitive dysfunction may facilitated benzodiazepine tapering add melatonin due anti inflammatory neuroprotective properties examined melatonin benzodiazepine withdrawal affect cognition subjective well psychosocial functioning eighty patients schizophrenia bipolar disorder randomized add treatment daily either prolonged release melatonin placebo week double blind clinical trial participants gradually tapered usual benzodiazepine dosage closely monitored treatment setting used brief assessment cognition schizophrenia bacs assess neurocognitive performance additional assessments subjective well psychosocial functioning bacs composite subscale scores except motor speed significantly improved parallel benzodiazepine dose reduction additional effect melatonin cognitive performance still markedly impaired post tapering compared normative data neither benzodiazepine withdrawal treatment group affected subjective well psychosocial functioning conclusion add melatonin seem affect cognition well psychosocial functioning patients severe mental illness observed improvement cognitive performance could distinguished retest effects may turn facilitated benzodiazepine tapering
chronic breathlessness common source psychological physical stress patients advanced progressive disease suggesting hypothalamic pituitary adrenal hpa axis dysregulation may prevalent aim study measure salivary diurnal cortisol profile patients receiving supportive palliative care range malignant non malignant conditions compare profile experiencing moderate severe disability due breathlessness patients mild breathlessness healthy controls saliva samples collected two consecutive weekdays awakening patients moderate severe breathlessness medical research council mrc dyspnoea grade patients mild breathlessness mrc dyspnoea grade healthy controls measures breathlessness stress anxiety depression wellbeing sleep examined concomitantly diurnal cortisol slope dcs calculated participant regressing log transformed cortisol values collection time mean dcs compared across groups using ancova individual slopes categorised one four categories consistent declining consistent flat consistent ascending inconsistent controlling age gender socioeconomic status mean dcs significantly flatter patients moderate severe breathlessness compared patients mild breathlessness healthy controls furthermore higher prevalence flat ascending cortisol profiles patients moderate severe breathlessness compared healthy controls variable correlated significantly dcs mrc dyspnoea grade findings suggest patients moderate severe breathlessness evidence hpa axis dysregulation dysregulation may related functional disability imposed breathlessness elsevier ltd rights reserved
chronic cardiovascular diseases significant health problems although current treatment strategies tremendously improved disease management patients successfully treated current treatment approaches new treatment strategies clearly needed gene therapy therapeutic vascular growth may provide new treatment option patients several growth factors like vascular endothelial growth factors fibroblast growth factors hepatocyte growth factor tested clinical trials however apart demonstration increased vascularity results clinical significance obtained problems gene transfer efficiency short duration transgene expression selection endpoints suboptimal patients gene therapy recognized ongoing gene therapy trials included improvements study protocols vector delivery endpoints addressing identified problems better targeted delivery systems new optimal growth factors taken clinical testing recent advances areas discussed concept angiogenic therapy sole treatment evaluated combination regenerative therapies standard revascularization operations might needed improve tissue function clinical benefits
chronic craniofacial pain involves head face oral cavity associated significant morbidity high levels health care utilization bidirectional relationship suggested literature poor sleep pain craniofacial pain sleep reciprocally related review relationship discuss management options part reviews relationship pain sleep disorders context four diagnostic categories chronic craniofacial pain primary headaches migraines tension type headache tth trigeminal autonomic cephalalgias tacs hypnic headache secondary headaches sleep apnea headache temporomandibular joint disorders tmd painful cranial neuropathies trigeminal neuralgia post herpetic trigeminal neuropathy painful post traumatic trigeminal neuropathy pttn burning mouth syndrome bms part discusses management patients chronic craniofacial pain sleep disorders addressing factors modulate pain experience well sleep disorders including non pharmacological pharmacological modalities elsevier ltd rights reserved
chronic diarrhoea common presenting symptom primary care medicine specialized gastroenterology clinics estimated population chronic diarrhoea nearly patients older years clinicians often need select best diagnostic approach patients choose multiple diagnostic tests available catalan society gastroenterology formed working group main objective creating diagnostic algorithms based clinical practice evaluate diagnostic tests scientific evidence available use grade system used classify scientific evidence strength recommendations consensus document contains recommendations diagnostic algorithms document also describes criteria referral primary specialized care elsevier espana aeeh aeg rights reserved
chronic exposure cocaine vivo induces long term synaptic plasticity associated brain circuitry underlies development repetitive automatic behaviors called habits fact prolonged drug consumption results aberrant expression protein coding genes small regulatory rnas including mirnas involved synaptic plasticity neuroadaptations however mechanisms mediating cocaine use disorder still fully understood present study designed examine expression mir mir mir mir well levels ago pum rest mrnas proteins implicated regulation applied rat cocaine self administration extinction training procedures yoked triad assess changes levels four mirnas three protein coding genes corresponding proteins dorsal striatum demonstrated elevated expression mature mir mir long lasting persists drug free period till day abstinence moreover mrna protein rest regulator neuronal transcription raised selectively cocaine self administering rats ago transcript decreased cocaine treatment unexpectedly expression level ago pum proteins changed active cocaine receiving animals results point important aspects long lasting alterations micrornas genes protein expressions involved control synaptic plasticity associated reward motivation learning related cocaine addiction
chronic exposure propiverine frequently prescribed pharmaceutical treatment overactive bladder incontinence provokes massive protein accumulation cytosol nucleus renal proximal tubule epithelial cells rats previously accumulating protein identified amino acid oxidase daao peroxisomal flavoenzyme expressed kidney liver brain cellular mechanism propiverine induced daao accumulation however remains unexplained poorly characterized therefore increase understanding daao accumulation rat kidney study aimed characterize daao accumulations using differential immunofluorescent staining rat kidney sections well vitro binding analyses proteasomal activity studies demonstrated propiverine neither ligand daao inhibitor proteasome vitro however propiverine treatment resulted significant decrease peroxisomal size rat proximal tubule epithelial cells moreover peroxisomal catalase also accumulated cytosol nuclei propiverine treated rats concurrently daao taken together study indicates propiverine treatment affects trafficking degradation peroxisomal proteins daao catalase far unique unknown mechanism
chronic hepatitis virus hcv infection leading cause hepatocellular carcinoma hcc need liver transplantation unclear hcv related outcomes vary race ethnicity aim evaluate ethnic disparities specifically among patients chronic hcv usa using data united network organ sharing registry evaluated race ethnicity specific disparities waitlist survival probability receiving among chronic hcv patients listed among hcv patients listed non hispanic white black hispanic asian hcv related waitlist registrations increased period proportion hcv patients hcc increased hcv patients hcc accounted hcv related waitlist registrations stratified race ethnicity hispanics hcv significantly lower waitlist mortality compared non hispanic whites significant differences seen among blacks asians furthermore compared non hispanic whites hispanics significantly less likely receive differences seen among blacks asians among patients chronic hcv usa meld score reduced race ethnicity specific disparities waitlist mortality however hispanic hcv patients significantly better waitlist survival lower probability receiving possibly reflecting slower disease progression compared non hispanic whites chronic hcv
chronic inflammatory rheumatic diseases ird including rheumatoid arthritis ankylosing spondylitis psoriatic arthritis prevalent conditions worldwide considerable burden healthcare systems associated increased cardiovascular morbidity mortality review focused epidemiology traditional risk factors genetics link chronic inflammation atherosclerosis disease remarkably patients ird higher vulnerability atheromatous plaques risk unstable plaques higher patients rheumatoid arthritis controls active disease characteristic ascribed vulnerability rupture plaques cause thrombosis ird management risk patients ird includes optimal control disease activity risk stratification applying risk charts also essential imaging techniques might useful determine actual risk patients ird included category intermediate moderate risk elsevier ltd rights reserved
chronic kidney disease ckd emerging worldwide epidemic data available african populations study assessed prevalence ckd adults living saint louis northern senegal population based survey january may adults living saint louis assessed sociodemographical clinical biological data collected household visits glomerular filtration rate estimated using variable modification diet renal disease equation factors associated ckd identified multivariate regression analysis mean age participants years majority participants lived urban areas school education overall prevalence rates hypertension diabetes mellitus obesity respectively prevalence ckd confidence interval estimated glomerular filtration rate less min study patients aware disease multivariable logistic analysis presence ckd significantly associated hypertension age study shows ckd frequent adult population northern senegal kidney health program urgently needed reduce disease burden urban rural areas
chronic liver disease cld starts becomes established adolescent young adult aya age group study aimed estimate trends cld prevalence among ayas assess factors associated cld cross sectional data ayas population weighted aged years enrolled national health nutrition examination survey used nonalcoholic fatty liver disease nafld defined elevated alanine aminotransferase females males subjects bmi alcoholic liver disease ald excessive alcohol use drinks day men drinks day women elevated aminotransferases excluding alternative etiologies participants considered hepatitis virus hcv positive antibody hcv hcv rna positive sharp increase prevalence cld remained stable nafld common etiology accounting cld later period prevalence ald steadily increasing throughout years hcv decreasing multivariate analysis overweight obese mexican american ethnicity later study period older age male gender associated higher odds cld one quarter ayas might affected cld cld prevalence age group doubled past three decades mainly due rise nafld prevalence
chronic migraine severely disabling neurological condition characterized episodes pulsating unilateral bilateral headache united states food drug administration fda approved onabotulinumtoxina botox prophylactic treatment shown onabotulinumtoxina effective reduction headache frequency severity patients treatment well tolerated patients review reports history botulinum neurotoxin bont presents current clinical evidence use onabotulinumtoxina treatment
chronic myelomonocytic leukemia cmml unique disease entity overlap components myelodysplastic syndrome myeloproliferative neoplasms cmml clonal hematopoietic stem cell neoplasm characterized monocytosis cytopenias extramedullary manifestations splenomegaly disease rare undergone revisions classification review recent classification strategies well diagnostic criteria focusing new insights genetic alterations unique pathophysiology disease also discuss latest molecular characterization disease including molecular factors affect current prognostic models finally focus available treatment strategies special emphasis experimental forthcoming therapies elsevier ltd rights reserved
chronic obstructive lung disease among leading causes adult hospital admissions readmissions united states preventing acute exacerbations primary approach therapy combinations smoking cessation pulmonary rehabilitation vaccinations inhaled oral medications may reduce overall risk acute exacerbations prevention unsuccessful treatment exacerbations often require hospitalization safely executed outpatient setting patient require mechanical ventilation manifests respiratory acidosis oxygen supplementation frequent short acting inhaled bronchodilators oral corticosteroids often antibiotics abort decompensation sometimes return patient pre attack baseline lung function several models exist delivering care ambulatory setting follow care exacerbation resolved important though hard data suggesting approach best setting
chronic obstructive pulmonary disease copd common worldwide predominant cause copd environmental exposure toxicants inflammatory processes copd multifactorial complex interacting leading many potential therapeutic targets although typically associated neutrophilic macrophagic inflammation type known copd also associated eosinophilic inflammation type particularly exacerbations accordingly active program investigation highly selective biologic therapeutic agents management copd review summarizes clinical trials use novel agents management copd
chronic renal liver heart failure children associates multiple skeletal complications increased fracture incidence often persists transplantation could related alterations bone material properties present cohort study evaluated bone mineralization density distribution bmdd quantitative backscattered electron imaging qbei pediatric solid organ allograft recipients suspected osteoporosis measured bmdd entire cross sectional area transiliac bone biopsies obtained kidney liver heart transplant recipients aged years years posttransplantation patients history clinical fractures bmdd findings compared age appropriate references previously presented cohort children chronic kidney disease dialysis ckdd furthermore related bmdd parameters patients clinical bone histomorphometric outcomes compared healthy children qbei results cancellous cortical bone transplant recipients revealed increase frequently occurring calcium concentration portion fully mineralized bone fivefold fold heterogeneity mineralization respectively moreover bmdd parameters nonsignificantly distinct ckdd cohort except heterogeneity mineralization higher posttransplantation strong inverse correlation average calcium content bone matrix patients biochemical alp levels histomorphometric indices bone formation resorption abnormally high bone matrix mineralization transplant recipients consistent serum histomorphometric outcomes suggests history low bone turnover accumulation fully mineralized bone packets additionally increased heterogeneity mineralization suggests local alterations mineralization kinetics may linked dysfunctional osteocytes recently shown accumulate within bone matrix organ failure concomitant glucocorticoid immunosuppressive medication american society bone mineral research
chronic unpredictable stress cus influence risk progression cancer increased oxidative stress pomegranate known protect carcinogenesis antioxidative properties study carried examine whether cus affects chemopreventive potential pomegranate oxidative stress pathway role cus early stages dimethyl benz anthracene dmba induced carcinogenesis pre exposure effect chemopreventive efficacy pomegranate juice examined terms vivo antioxidant biochemical parameters swiss albino rats rats divided various groups subjected cus paradigm dmba administration body weight single dose treatment exposure stress alone dmba alone led increased oxidative stress significantly decreasing antioxidant enzymes activities altering glutathione gsh malondialdehyde mda glutamate oxaloacetate transaminase got glutamate pyruvate transaminase gpt levels significant increase dna damage demonstrated comet assay seen liver cells stress exposure dmba treated rats increased oxidative stress disturbed biochemical parameters compared dmba alone treated rats chemoprevention dmba alone treated rats restored altered parameters however pre stress dmba treated rats overall antioxidant potential significantly diminished results indicate chronic stress increases severity carcinogenesis also diminishes anti oxidative efficacy broader perspective special emphasis given stress management healthy diet cancer chemoprevention
chronic long term respiratory morbidity crm common patients history repaired congenital esophageal atresia typically associated tracheoesophageal fistula tef tef patients high risk aspiration retrospective studies associated crm recurrent aspiration atopy however studies evaluating association crm population either aspiration atopy reported conflicting results furthermore crm population may due related conditions well tracheomalacia recurrent infections aspiration difficult confirm short lung biopsy moreover even within largest evidence base assessing association crm aspiration evaluated potential relationship gastroesophageal reflux asthma findings contradictory studies attempting relate crm prior aspiration events may inadequately estimate frequency severity previous aspiration episodes convincing evidence documenting chronic massive aspiration patients repaired tef associated development bronchiectasis chronic aspiration likely associated crm patients repaired tef appear confirmed data currently available prospective studies systematically evaluate aspiration risk allergic disease patients repaired tef document subsequent crm needed clarify causes crm population given prevalence crm patients repaired tef ideally receive regular follow multidisciplinary teams expertise condition throughout childhood adulthood
chronic kidney disease unknown etiology ckdu reported developing countries like sri lanka india central america without sparing indian sub district namely canacona located south goa disease etiology unlinked common causes diabetes hypertension assumed environmentally induced due asymptomatic nature occurrence groundwater relying communities study aimed understand environmental risk factors underlying ckd uetiology using indian sub district canacona case study biochemical analysis ckdu affected non affected individual blood detailed hydro geochemical analyses ckdu affected non affected region groundwater drinking water conducted trace geogenic element silica highly dominant affected region groundwater thus nephrotoxic potential analysed via vitro cytotoxicity assays human kidney cell lines ckdu affected subjects showed increased levels serum urea creatinine uric acid normal blood glucose distinct biomarkers environmentally induced ckd thronic tubulo interstitialnephritis affected subjects reported high blood lead levels suggesting direct nephrotoxicity resulting impaired blood clearance also exhibits indirect nephrotoxicity disrupting calcium homeostasis causing skeletal disorders prolonged consumption nsaid pain alleviation indirectly causing renal damage affected region groundwater acidic resulting borderline lead high silica mgl contamination silica bio availability determining nephrotoxicity enhanced groundwater acidic deficient composition since cations complex silica reducing bioavailability silica exhibited renal proximal tubular cytotoxicity long term exposure comparable affected region groundwater silica levels apoptosismediated cell death resulting tubular atrophy interstitial fibrosis irreversible renal damage ckd thus study provides novel insights nephrotoxic potential trace geogenic elementsilica ckdu causation highlights direct indirect nephrotoxicity exhibited lead low levels due bio accumulative capacity silica nephrotoxic potential considered deciphering etiology ckdu problem developing countries relying groundwater elsevier ltd rights reserved
circadian rhythms sleep wake cycle along range physiological measures severely disrupted individuals major depressive disorder mdd moreover several central circadian genes implicated potential genetic factors underlying illness candidate gene studies genome wide association studies however investigations molecular underpinnings circadian disturbances human brain quite challenging recent publication colleagues used novel approach determine rhythmic patterns circadian gene expression several regions human brain patterns disrupted mdd findings demonstrate healthy subjects several brain regions outside suprachiasmatic nucleus master clock exhibit diurnal gene expression patterns disrupted brains mdd subjects findings provide foundation future studies gene specific drug targets biomarkers disease
circadian typology morning type neither type evening type individual difference related numerous aspects mental health paper present review findings published topic searching main databases total number works selected published spanish english collected databases isi scopus medline works show individuals evening type typology exhibit greater prevalence seasonal affective disorder mayor depression bipolar disorder schizophrenia eating disorders sleep disorders addictive behaviours adhd higher anxiety levels morning type typology individuals sense evening type considered factor risk whereas morning type would protective factor development several mental disorders could result clock gene polymorphisms social jet lag personality traits circadian typology must considered evaluation treatment prevention mental disorders affects start course remission relapse diverse problems mental health chronobiological therapy must also considered therapeutic approaching circadian rhythmical expression altered
circulating micrornas presented venous plasma demonstrated powerful biomarkers complex diseases like cancer nevertheless presented arterial plasma remained largely unexplored using microarray technique compared microrna expression profiles matched arterial venous plasma samples male rats though microrna profiles largely similar identified differentially expressed micrornas including arterial highly expressed micrornas venous highly expressed micrornas differentially expressed micrornas validated qrt pcr computational analysis micrornas targets indicated arterial highly expressed micrornas overrepresented functional terms like hematopoiesis diseases like crohn disease leukemia venous highly expressed micrornas enriched cell differentiation function diseases like distal myopathies heart failure analysis also suggested significant correlations plasma microrna expression tissue microrna expression four arterial highly expressed micrornas also showed enriched expression specific tissues would novel biomarker candidates
cissus quadrangularis cissus medicinal plant commonly used centuries various conditions lacks critical appraisal clinical effects study aimed determine efficacy safety cissus conditions publications electronic databases searched inception november total nine studies patients included outcome pooled using random effects model effects cissus hemorrhoid symptoms different comparators significant effects bone pain effects cissus combination products body weight reduction low density lipoprotein triglyceride total cholesterol fasting blood sugar superior placebo weighted mean difference respectively serious adverse effects reported quality evidence based grades recommendations assessment development evaluation grade indicated low bone fractures high quality hemorrhoids body weight reduction conclusion cissus benefit bone fractures hemorrhoids obesity overweight combination products pooled show benefit however high quality studies remain needed copyright john wiley sons ltd
cities described masculine simultaneously emancipatory women giving possibility experiment new identities women gained access masculine sphere working life financial independence new interest among families live inner cities interpreted way particularly mothers combine work family life drawing depth qualitative study paper investigates mothering fathering practices family leave helsinki finland explores parenting incorporated mothers fathers urban self identity argues parenting city traditional gender roles blurred paper proposes term domesticfication describe urban middle class mothering fathering inscribed nordic contemporary urban space
cities play prominent role economic development gross world product gwp comes cities urban areas world population generate gwp rapid urbanization climate change inadequate maintenance water wastewater infrastructures poor solid waste management may lead flooding water scarcity water pollution adverse health effects rehabilitation costs may overwhelm resilience cities megatrends pose urgent challenges cities cost inaction high present overview population growth urbanization water waste climate change water governance transitions background discuss categorization cities based baseline assessments city blueprint research municipalities regions predominantly europe bias towards europe mind challenges discussed globally clustering cities distinct categories sustainability providing additional data information global regions distinguish five categories sustainability cities lacking basic water services wasteful cities water efficient cities resource efficient adaptive cities water wise cities many cities western europe belong categories cities eastern europe cities assessed latin america asia africa categorized cities lacking basic water services lack water infrastructures obsolete infrastructures solid waste management climate adaptation priorities concluded cities require long term framing sectoral challenges proactive coherent urban agenda maximize benefits adaptation minimize cost furthermore regional platforms cities needed enhance city city learning improve governance capacities necessary accelerate effective efficient transitions towards water wise cities learning alliances needed time window solve global water governance crisis narrow rapidly closing water sector play important role needs reframe refocus radically
civic learning teaching form critical democratically engaged pedagogy utilized upper level undergraduate sexual ethics course leverage public problem solving around sexual violence mid size catholic collegiate campus course students faculty staff community members work together deepen understanding causes consequences sexual violence within society local community order evaluate design programming bystander intervention education sexual violence prevention advocacy discussion application civic teaching learning sexual violence course module describes learning outcomes assignments used assess see well donna freitas response essay risk reward teaching sexual assault theologian catholic campus published issue journal
inhibitor cinh multi functional serine protease inhibitor plasmatic cascades inactivating various proteases also regulating complement contact system activation study described identification characterization cinh ortholog nile tilapia oreochromis niloticus molecular protein cellular levels full length cdna oreochromis niloticus cinh oncinh consisted nucleotide sequence encoding polypeptides amino acids deduced protein possessed serpin domain terminal domain two like domains terminal domain significant homology teleost expression analysis revealed oncinh extremely highly expressed liver however much weakly exhibited tissues including spleen kidney blood heart vivo challenges lipopolysaccharide lps streptococcus agalactiae expression oncinh significantly regulated liver spleen late phase confirmed protein level immunohistochemical analysis regulation oncinh expression also demonstrated head kidney monocytes macro phages vitro stimulated lps aeromonas hydrophila streptococcus agalactiae positively correlated protein expression pattern culture media taken together results study indicated oncinh might involved immune response nile tilapia bacterial challenge elsevier ltd rights reserved
classical computing shifted gradually cloud offering completely new possibilities information usage computing power application learning algorithms paper cloud based architecture control systems investigated showing benefit multi stage production systems sequential manufacturing assembly processes connected via cloud based architecture allows using information previous production step one subsequent steps downstream deviation compensation strategy applied rotor production electric motors automotive industry current production shows high defect rates due lack adequate sensor signals optimization algorithms magnetization process permanent magnets executed saturation generation deviations avoided process control process optimization instead variance magnetization signal must compensated downstream process rotor assembly stage project results show cloud based architecture increase product quality decreasing amount scrap parts real industrial scenario consequently saving valuable resources like energy raw materials reduction deviations crucial emerging industrial sector electric motor production vehicles moving towards mass production
climate change shown increase number mountain lakes across various mountain ranges world central asia particular territory uzbekistan detailed assessment glacier lakes evolution time however lacking reason created first detailed inventory mountain lakes uzbekistan based recent satellite observations usingworldview spot ikonos imagery spatial resolution record complemented data field studies last years previous data mostly form inventories lakes available soviet archives primarily included localized situ data inventory mountain lakes presented contrast includes overview lakes territory uzbekistan lakes considered located altitudes lakes area exceeding mountain regions world ongoing increase air temperatures led increase lake number area moreover frequency overall number lake outburst events rise well therefore also present first outburst assessment updated version well known approaches considering local climate features event histories result lakes identified territory uzbekistan considered prone outburst lakes assigned low outburst potential remainder lakes average level outburst potential conclude distribution lakes elevation shows significant influence lake area hazard potential significant differences contrast exist distribution lake area outburst potential lake location respect glaciers regions elsevier rights reserved
climate change impacts arctic differentiated gender yet empirical studies investigated use case study inuit community iqaluit nunavut identify characterize vulnerability adaptive capacity inuit women changing climatic conditions interviews conducted inuit women complimented focus group discussions participant observation examine women experienced responded changes climate already observed three key traditional activities identified exposed sensitive changing conditions berry picking sewing amount time spent land several coping mechanisms described help women manage exposure sensitivities altering timing location berry picking importing seal skins sewing adaptive capacity employ mechanisms differed among participants however mental health physical health traditional western education access country food store bought foods access financial resources social networks connection inuit identity emerged key components inuit women adaptive capacity study finds gender roles result different pathways changing climatic conditions affect people locally although broad determinants vulnerability adaptive capacity women consistent identified men scholarship broadly
climatic conditions commonly considered primary determinant consumers choices energy use heating besides current regulations matter focus physical characteristics buildings relying strict relationship efficiency savings nevertheless literature shows energy demand determinants difficult estimated accuracy required predictive purposes energy savings stemming efficiency gains partly outweighed consumers behavior deal issues analyzing spatial series data natural gas consumptions space heating hot water production residential sector regression analysis takes four fields covariates account climate building characteristics market aspects technological development estimation process based following cornerstones spatially lagged dependent variable deal problem spatial autocorrelation linear logarithmic functional forms two stage interpolation strategy meant provide unbiased estimates dispersion matrix statistics combining ordinary least squares weighted least squares models turn well specified explanatory power high results suitable demand forecasting although spatial autoregressive term appear among significant regressors show space matter shaping natural gas consumption different regions analysis proves heating gas demand characterized positive elasticity income use results provide estimates rebound effect nevertheless additional consumption directly attributable income effect moderate magnitude gas price vary elsevier ltd rights reserved
clinical data sharing healthcare institutions practitioners often hindered privacy protection requirements problem critical collaborative scenarios data sharing fundamental establishing workflow among parties anonymization patient information burned dicom images requires elaborate processes somewhat complex simple identification textual information usually sharing need manual removal specific areas containing sensitive information images paper present pipeline ultrasound medical image identification provided free anonymization rest service medical image applications software service streamline automatic identification medical images freely available end users proposed approach applies image processing functions machine learning models bring automatic system anonymize medical images perform character recognition evaluated several machine learning models convolutional neural networks cnn selected best approach accessing system quality processed images manually inspected showing anonymization rate tool accessed https bioinformatics dicom anonymizer available recent version google chrome mozilla firefox safari docker image containing proposed service also publicly available community
clinical evidence accumulating role microbiome contributing modulating severity inflammatory diseases studies organized various organ systems involved well type study approach utilized whether investigators compared microbiome cases versus controls followed patients longitudinally intervened antibiotics prebiotics bacterial introduction review summarize clinical evidence supporting microbiome important mechanism onset maintenance inflammation
clinical evidence supports need changing diagnostic criteria updated classification polycythemia vera essential thrombocythemia primary myelofibrosis pmf jak mutated patients show characteristic bone marrow morphology clinical studies demonstrated hemoglobin level men women hematocrit value men women optimal cut levels distinguishing jaic mutated masked prodromal therefore morphology upgraded major diagnostic criterion regarding key issue improve standardization prominent features enhancing differentiation true prefibrotic early primary myelofibrosis prepmf two entities shown different epidemiology clinical outcomes concerning prepmf explicit clinical characterization minor criteria mandated improved distinction overt pmf accurate diagnosis outcome prediction elsevier ltd rights reserved
clinical observation suggests might important overlap borderline personality disorder bpd autism spectrum disorders ass given background aim study investigate autistic traits patients borderline personality disorder special attention cognitive empathy alexithymia women borderline personality disorder participated autistic traits assessed autism spectrum quotient facets empathy interpersonal reactivity index iri und alexithymia toronto alexithymia scale tas results show almost half bpd patients scored beyond ass cut subgroup high autistic traits lower scores cognitive empathy higher alexithymia scores implications clinicians discussed
clinical studies indicate reciprocal impact nicotine use antipsychotic medications patients schizophrenia present study used conditioned avoidance response car test behavioral test antipsychotic effect examined specific drug drug interactions nicotine haloperidol clozapine following acquisition avoidance response rats first tested either vehicle nicotine haloperidol clozapine combination nicotine haloperidol nicotine clozapine seven consecutive days afterward challenged nicotine haloperidol clozapine car assess haloperidol clozapine affected behavioral effect nicotine avoidance response nicotine altered avoidance suppressive effect haloperidol clozapine seven avoidance drug test days nicotine alter avoidance suppressive effect haloperidol clozapine however challenge test prior nicotine treatment attenuated haloperidol sensitized effect avoidance response hand prior haloperidol treatment increased nicotine avoidance disruptive effect even engendered nicotine exhibit acquired avoidance suppressive effect combined nicotine clozapine treatment produce detectable interactive effects avoidance response motor activity findings suggest nicotine capable altering long term antipsychotic efficacy haloperidol haloperidol alter behavioral effects nicotine clozapine nicotine less likely influence
clinical trial design amyotrophic lateral sclerosis als remains hampered lack reliable sensitive biomarkers disease progression present study evaluated peripheral nerve diffusion tensor imaging dti surrogate marker axonal degeneration als longitudinal studies undertaken als patients studied months patients months results compared age matched controls imaging metrics correlated across range functional assessments including amyotrophic lateral sclerosis functional rating scale revised alsfrs lower limb muscle strength medical research council sum score mrcss compound muscle action potential amplitudes motor unit number estimation mune fractional anisotropy reduced baseline als patients tibial peroneal nerve fractional anisotropy axial diffusivity declined tibial nerve baselines month scans functional perspective alsfrs correlated fractional anisotropy values tibial peroneal nerves similarly peroneal nerve mune values correlated fractional anisotropy values tibial peroneal nerve correlations change alsfrs tibial nerve axial diffusivity change mrcss peroneal nerve fractional anisotropy conclusion study demonstrated peripheral nerve dti metrics sensitive axonal degeneration als dti metrics correlated measures functional disability strength neurophysiological measures lower motor neuron loss
clinicians currently use different low weight cut offs diagnose anorexia nervosa determine severity adolescent girls purpose study evaluate clinical utility existing cut offs severity criteria determining strongly associated risk low bone mineral density bmd height adjusted bmd scores calculated females healthy controls controls years using data bmd childhood study lumbar spine whole body less head total hip cut offs used define low weight bmi percentile bmi median bmi lower bmd scores controls expected body weight height ebw differ bmd scores controls differed significantly ebw among amenorrhea associated lower bmd lower bmd controls across dsm society adolescent health medicine sahm severity categories sahm moderate severity classification differentiated mildly malnourished classification lower bmd hip spine sites amenorrhea ebw markers severity bone loss within among severity categories bmi scores sahm may greatest utility assessing degree malnutrition adolescent girls corresponds lower bmd
cloud computing paradigm information permanently stored servers internet cached temporarily clients virtual private network vpn widely used technology secure cloud access unfortunately vpn based cloud services become unavailable vpn failure occurs paper propose new scheme improve availability vpn connections failures called high availability virtual communication havc unlike multipath transmission schemes literature proposed scheme implemented using virtualization technique protocol functions independent existing networks potential clients required modify applications operating systems simulation results show havc tolerate vpn failures also achieve high transmission performance
cloud computing set information technology services provided customer network leased basis ability scale service requirements cloud computing new general purpose internet based technology information stored servers provided service demand clients builds decades research virtualization distributed computing utility computing recently networking web software services implies service oriented architecture reduced information technology overhead end user great flexibility reduced total cost ownership demand services many things paper discusses concept cloud computing issues tries address available cloud computing implementation
cloud computing one increasing technology connected grid computing utility computing distributed computing today world securing data plays vital role computing environment data privacy data security popular fields like government industry business future development inter related hardware software hence paper analyses data security solutions cloud computing
cloud computing one information technology services provided infrastructures application services combination distributed computing virtualization technology using virtual machines essential component cloud computing therefore task scheduling important matter consider virtual machines balance load machine efficiently use resources cloud computing paper proposes use heuristic task scheduling artificial bee colony algorithm virtual machines heterogeneous cloud computing called habc research aim introduce habc new task scheduling load balancing algorithm virtual machines heterogeneous environments reduce makespan system experiments cloudsim simulated compare various types optimization task scheduling using virtual machines experimental results indicated using proposed artificial bee colony algorithm large job considered first habc ljf virtual machine scheduling improved efficiency task scheduling load balancing virtual machines cloud computing addition proposed algorithm minimize makespan even tasks increased different types data distributed
cloud computing proven service delivery model internet network play important role service provisioning cloud network major security issue service delivery network security reliability achieve together much difficult task day cloud traditional network replaced programmable unified software defined network separate control plane data plane managing network traffic sdn capability reduce cost networking device using network virtualization facilitate hardware software virtualization using nfv network function virtualization sdn nfv integration cloud computing give power virtualization improve network security service paper describe sdn nfv integrate openstack cloud minimize network attack surface improve network service provide salient advantage sdn
cloud computing long envisaged vision computing utility innovative advances hardware networking middleware virtual machine technologies led emergence new globally distributed computing platforms namely cloud computing cloud computing provides computation facilities storage services accessible anywhere via internet without investing new infrastructure training software licensing words cloud computing way increase capacity add capabilities dynamically main advantage cloud computing users utilize require pay really use exponential growth mobile applications evolution cloud computing concept mobile cloud computing mcc presented potential technology mobile services mcc incorporates cloud computing mobile environment mobile cloud computing refers infrastructure data processing storage happen away mobile device mobile cloud computing mcc transformed way mobile users across globe leverage services obstacles related performance battery life storage bandwidth environment heterogeneity scalability availability security reliability privacy overcome integrating cloud computing mobile environment using mcc mobile cloud service model mobile device use cloud information storage searching data mining multimedia processing cloud computing technology also brings forth many new challenges data security access control users store sensitive data cloud servers users longer physical possession outsourced data makes data integrity privacy authenticity protection cloud computing challenging potentially difficult task though cloud computing benefits clear surrendering physical possession user data inevitably poses new security risks paper discuss mobile cloud computing security frameworks found literature related cloud computing environment
cloud computing represents recent enterprise trend information technology refers virtualization computing resources available demand cloud computing saves cost time businesses moreover computing process reflects radical technological revolution companies develop deploy manage enterprise applications internet virtualized cloud computing mainly offers cloud computing delivery models software service platform service infrastructure service security privacy presently considered critical factors adaptation cloud service delivery model cloud computing leverages several technologies process model inherit potential security threats thus far security issues cloud computing rarely addressed service delivery level key security concerns include web application security network security data security integration vulnerabilities virtualized environment physical security aim research comprehensively present security threats respect cloud service deliver models study also determines service delivery models differ existing enterprise applications classify models investigate inherent security challenges study primarily focuses security concerns layer cloud service delivery model well existing solutions approaches addition countermeasures potential security threats also presented cloud model copyright john wiley sons ltd
cloud environments become standard method enterprises offer applications means web services data management systems simply renting computing resources previous work presented use modeling language together new features java overcome certain drawbacks data structures synchronization mechanisms parallel applications extend solution design pattern allows application specific optimizations distributed setting validate integration using previous case study prime sieve eratosthenes illustrate performance improvements terms speed memory consumption copyright john wiley sons ltd
cloud based mobile networks foreseen technological enabler next generation mobile networks design requires substantial research pose unique challenges especially point view additional delays fronthaul network commonly used network protocols therefore adjusted cope peculiarities networks paper investigate optimized design transmission control protocol tcp plays central role mobile networks ensure optimal performances application layer services tcp implementations popular operating systems investigated network model results influential parameters used design optimized tcp cloud based mobile networks
cloud based software service saas providers want grow space business process outsourcing bpo bpo refers systematic controlled delegation many steps company business process bpo new important extension saas allows provider add value online application services enables outsourcer obtain cost efficiency bpo results decentralized federated workflows describe workflows companies often use business process modeling languages currently business process modeling notation bpmn one best known standards crucial ascertain modeled workflow executed intended errors happen execution federated workflow come huge costs validating model limited syntactical checks little support validating execution design time paper method presented validate correct execution bpmn collaborations methods research use concepts virtual time previously described web services choreography description language cdl validate results research eclipse bpmn modeler extended implementation validation method
clustering one important data mining issues especially large distributed data analysis distributed computing environments peer peer networks involve separated scattered data sources distributed among peers according unpredictable growth dynamic nature networks data peers constantly changing due high volume computing communications privacy concerns processing types data applied distributed way without central management today applications systems focus unstructured systems unstructured networks spreading gossip simple efficient method communication adapt dynamic conditions networks recently algorithms different pros cons proposed data clustering networks paper combining novel method extracting representative data gossip based protocol new centralized clustering method gossip based distributed clustering algorithm networks called gbdc proposed gbdc algorithm suitable data clustering unstructured networks adapts dynamic conditions networks gbdc algorithm peers perform data clustering operation distributed approach communications neighbours gbdc need rely central server performs asynchronously evaluation results demonstrate superior performance gbdc algorithm also comparative analysis well established methods illustrates efficiency proposed method elsevier rights reserved
clustering regarded one significant task data mining widely used large data sets soft clustering unlike traditional hard clustering allows one data belong two clusters soft clustering fuzzy means rough means proposed successfully applied deal uncertainty vagueness however influx large amount noisy blur data increases difficulties parallelization soft clustering techniques question deploy clustering algorithms tremendous amount data get clustering result within reasonable time paper provides overview mainstream clustering techniques proposed past decade trend progress clustering algorithms applied big data moreover improvement clustering algorithms big data introduced analyzed possible future advanced clustering techniques illuminated based today information era
cobalamin deficiency common patients crohn disease intramuscular cobalamin continues standard therapy deficiency maintenance treatment patients although oral route demonstrated effective pathologies impaired absorption aims evaluate efficacy oral therapy treatment cobalamin deficiency long term maintenance patients crohn disease performed multicenter retrospective cohort study included patients crohn disease cobalamin deficiency seventy six patients deficiency normalized cobalamin levels oral treatment used dose day significant differences treatment effectiveness depending dose used eighty two patients previous documented deficiency treated oral maintain correct cobalamin levels mean follow years oral route effective maintenance treatment patients lack treatment adherence admitted patients oral route failed conclusion study shows oral cyanocobalamin provides effective acute maintenance treatment vitamin deficiency caused without ileum resection
cocaine addiction growing health problem among complications highlights high prevalence mental disorders occurring abuse dependence psychopathological comorbidity varies according time consumption age patient early detection psychopathological disorders associated drug consumption necessary optimize health care improve prognosis main aim present study estimate prevalence characteristics psychopathological comorbidity population subjects seeking outpatient treatment cocaine use recruited subjects using cocaine nasal insufflations evaluated prism psychiatric research interview substance mental disorders semi structured diagnostic interview differentiates primary mental disorders induced drug population presented male mean age displayed pathological use cocaine years presence psychopathology associated higher number dsm diagnostic statistical manual mental disorders criteria substance dependence lifetime prevalence psychopathological comorbidity highlighting mood disorders followed anxiety disorders psychotic disorders showed antisocial personality disorder borderline personality disorder among mood psychotic disorders induced disorders frequent primary disorders prevalent anxiety
cocaine addiction characterized alterations motivational cognitive processes recent studies shown alterations present cocaine users may related activity large functional networks aim study investigate functional networks modulated non drug rewarding stimuli cocaine dependent individuals twenty abstinent cocaine dependent healthy matched male controls viewed erotic neutral pictures undergoing functional magnetic resonance imaging scan group independent component analysis performed order investigate functional networks modulated reward cocaine addicts results showed cocaine addicts compared healthy controls displayed diminished modulation left frontoparietal network response erotic pictures specifically unpredicted additionally positive correlation length cocaine abstinence modulation left frontoparietal network unpredicted erotic images found agreement current addiction models results suggest cocaine addiction contributes reduce sensitivity rewarding stimuli abstinence may mitigate effect
cocaine addiction remains serious challenge clinical medical research effective pharmacological treatment thp natural product isolated corydalis yanhusuo wang one frequently used traditional herbs treat drug addiction china laboratory first reported demethylated metabolites icp high affinity dopamine receptors report chemical synthesis metabolites derivatives binding affinities dopamine receptors synthesis bioactive metabolites allow vivo study potential treating cocaine addiction published elsevier ltd
cocaine use induce transient psychotic symptoms include suspiciousness paranoia hallucinations cocaine related behaviors commentary authors provide international perspective reviewing recent advances epidemiology clinical features risk factors related cocaine induced psychosis exhibited patients cocaine use disorders settings occurrence cocaine induced psychosis shown high many risk factors linked cocaine induced psychosis including quantity cocaine consumed lifetime amount cocaine use onset cocaine dependence years use routes administration substance use disorder comorbidity weight gender comorbidity medical mental health disorders genetics pharmacological interactions research shown evaluation cocaine induced psychosis patients cocaine use clinically relevant especially patients consume high amounts cocaine cannabis dependence history antisocial personality disorder use administration routes intranasal exhibit attention deficit hyperactivity disorder adhd comorbidity currently literature lacks information regarding evolution cocaine dependence cocaine dependent patients risk developing schizophrenia psychotic disorders furthermore clinicians still evidence based pharmacological approach management cocaine dependence available additional research also needed regarding risk factors neurobiological markers personality traits finally recommend development integrative model including risk factors protective factors cocaine induced psychosis
code cloning one active research areas software engineering community specifically researchers conducted numerous empirical studies code cloning reported code typical software system cloned however less awareness code clones dynamically typed languages studies limited statically typed languages java addition previous studies consider different application domains standalone projects web applications result little known clones dynamically typed languages javascript different application domains paper report large scale clone detection experiment dynamically typed programming language javascript different application domains web pages standalone projects experimental results showed unlike javascript standalone projects javascript web applications inter file clones widely scattered clones observed web application developers created clones intentionally clones may risky claimed previous studies understanding risks cloning web applications requires studies cloning may due either good bad intentions also identified unique development practices including browser dependent device specific code code clones javascript web applications indicates features programming languages technologies affect developers duplicate code
cognitive decline major biomedical challenge global population ages elevated levels longevity factor klotho suppress aging enhance cognition promote synaptic plasticity neural resilience aging alzheimer disease related pathogenic proteins examined relationship human genetic variants klotho systemic klotho levels assessed neuroanatomic correlates serum klotho cohort healthy older adults serum klotho levels increased heterozygosity anticipated report first time serum klotho levels paradoxically decreased homozygosity found higher serum klotho levels associated measures greater intrinsic connectivity key functional networks brain vulnerable aging fronto parietal default mode networks findings suggest elevated klotho promotes resilient brain possibly increased network connectivity critical brain regions
cognitive impairments depression common non motor manifestations parkinson disease recent evidence suggests partially arise via frontostriatal network opening opportunity concomitant treatment non invasive brain stimulation nibs techniques repetitive transcranial magnetic stimulation rtms transcranial direct current stimulation tdcs systematic review evaluate effects nibs cognition mood placebo controlled studies involving patients outcomes depended area stimulated technique used rtms dorsolateral prefrontal cortex dlpfc resulted significant reductions scores depressive symptoms moderate large effect sizes along increased performance several tests cognitive functions tdcs dlpfc improved performance several cognitive measures including executive functions large effect sizes additional effects tdcs mood detectable however non depressed patients assessed confirmatory research needed clarify contribution nibs could make care patients elsevier ltd rights reserved
cognitive radio systems intended opportunistic spectrum access large portion mobile radio spectrum require highly isolated wideband multiport antennas subject paper approach mapping characteristic modes cms radiation modes rms build multiple input multiple output mimo antenna system meeting requirements isolation bandwidth set mutually orthogonal rms antenna system constructed superpositions cms chassis device exploitation orthogonality properties permutation relations couplers due symmetry complexity matching network number tunable reactances reduced approach applied design four port antenna system femto cell form factor device operating mhz range proceed computation cms device selection efficient ones excitation couplers whose locations respect symmetry structure current density distributions chosen modes theoretical considerations simulations compared measured results hardware prototype
cognitive emotional arousal responses violent games play central role theoretical explanations violent media may affect aggression however existing research focused relatively narrow range responses violent games experimental settings limits understanding whether violent game induced responses relate aggression real life address gaps study investigated cognitive effort emotional valence arousal response violent games relate early adolescents aggression cross sectionally period one year addition investigated social context variable family conflict predicts responses violent games subsequent aggression sample early adolescents years completed survey questions media diaries measured responses violent games results showed outside lab positive cross sectional relationship violent game induced arousal aggression exists addition arousal mediated relationship family conflict aggression study findings justify increased research attention media responses outside lab need theoretical methodological refinement elsevier ltd rights reserved
coherent techniques expected used meet demand higher data rates short reach optical links near future digital coherent receivers used long haul applications suitable short reach links excessive power dissipation size cost power consumption size cost receiver drastically reduced processing signals analog domain dual polarization quadrature phase shift keying receiver uses analog domain signal processing presented receiver designed bicmos technology consumes power simulations show bit error rates less presence dispersion laser linewidths khz frequency offset mhz transmitter receiver lasers
collaborative systems form warp smart networked environments wherein humans organizations intelligent agents devices collaborate smart environments near future context sensitive systems within physical world richly transparently interwoven sensors actuators computational elements seamlessly embed everyday objects interconnect networks modeling design development collaborative systems context support large number emerging applications including security care assistance transportation construction sustainability energy management education government manufacturing context brief survey trends challenges presented
colloidal quantum dots cqds highly versatile nanoscale optoelectronic building blocks despite materials engineering flexibility considerable lack fundamental understanding electronic structure couple within thin films employing joint experimental theoretical study reveal impact connectivity cqd assemblies going beyond single cqd picture high resolution transmission electron microscopy tem demonstrates connectivity motifs across different cqd sizes length scales provides necessary perspective build robust computational models systematically study achievable degree connectivity materials focused state art surface ligand treatments taking account degree connectivity nanocrystal orientation performed initio simulations within phonon assisted hopping regime importantly tem studies simulation results revealed morphological electronic defects could dramatically reduce optoelectronic performance yet would captured within single cqd model neglects connectivity calculate carrier mobility presence defect states conclude best achievable cqd assemblies optoelectronics require modest degree fusing via facet followed atomic ligand passivation generate clean band gap unprecedentedly high charge transport
combined hormonal contraceptives chcs contain estrogen progestin stimulate estrogen sensitive progesterone sensitive breast cancer growth recently ethinylestradiol almost estrogen used decades dose greatly reduced time first generations birth control pills contained approximately five times estrogen four times progestin latest contraceptives newer chcs also contain steroids closely mimic physiological estradiol progesterone effects newer chc formulations thus expected less influence breast although difficult demonstrate difference among recent available preparations human studies recently nomegestrol acetate nomac neutral nonandrogenic progesterone like profile progestin become available combination natural estrogen according literature nomac expected either lesser stimulating effect neutral effect estrogen sensitive breast cancers performed analysis available studies bibliographical review endocrine metabolic effects nomac formulation might lead lesser breast tissue stimulation data reported confirmed clinical studies considered choosing hormonal contraceptive especially breast stimulation concern anti cancer drugs wolters kluwer health vertical bar lippincott williams wilkins
combined power characteristics electric vehicles modern internet vehicles paper proposes new optimization algorithm speed electric vehicles based fuzzy theory conventional pid control rules study characteristics different factors process driving wherein park equation used establish relationship motor current dynamic situation selection input variables takes internet vehicles technology account consideration target energy conservation acceleration defined output variable whole optimization algorithm proved accurate circumstances examination matlab fis illustrates new algorithm better control effect providing new method fuzzy pid control speed electric motor
combining substructure finite element model updating method response surface model updating method one novelty finite element model updating method bridge structure proposed updating finite element model certain combined cable stayed suspension model bridge light specific configurations mechanical features combined cable stayed suspension bridge substructures partitioned updating design parameters need updated preselected basis variance analysis updating parameters determined parameter significance test samples updating parameters obtained homogeneous design method corresponding structural responses obtained finite element analysis finally response surface model updating parameter fitted verified jointed objective function linear combination fitness functions based natural frequency static displacement introduced experimental data static dynamic testing model bridge adopted update design parameters genetic algorithm minimization discrepancies measurements finite element model updating results achieved experimental results show updated parameters obtained proposed method reasonable clear physical meaning finite element model bridge structure updated effectively proposed finite element model updating method elsevier ltd rights reserved
commercial buildings central cities contribute significantly urban demand natural resources including freshwater green building benchmarking tools include efficient water use key indicator sustainability paper explores options substituting mains drinking water alternative non potable water source fit purpose basis research findings based monitoring study commercial building brisbane australia harvesting rainwater meeting non potable water demand results demonstrated system achieving moderate reliability meeting demand due operational problems case study analysis highlighted need include validation monitoring ensure system operating per design intent paper also investigates potential local non potable water sources high rise commercial buildings particular air conditioning condensate groundwater inflow basement wet well paper concludes comparing advantages disadvantages different local water sources highlights need undertake site specific investigation identify suitable alternative water source considers complexity capacity facilities management crown copyright published elsevier rights reserved
communication cortical regions necessary optimal cognitive processing functional relationships cortical regions inferred measurements temporal synchrony spontaneous activity patterns relationships elaborated surveying effects cortical lesions upon inter regional connectivity lesions cortical hubs heteromodal association regions expected induce distributed connectivity changes higher order cognitive deficits yet functional consequences remain relatively unexplored used resting state fmri investigate intrinsic functional connectivity graph theoretical metrics patients circumscribed lesions medial prefrontal cortex mpfc portion default network compared metrics observed healthy matched comparison participants sample healthy individuals despite significant mpfc destruction patients demonstrate weakened intrinsic among undamaged nodes instead network specific changes manifested weaker negative correlations attentional somatomotor networks findings conflict homogenous system functionally anchored mpfc rather implicate role mpfc mediating cross network functional interactions broadly data suggest lesions association cortical hubs might induce clinical deficits disrupting communication interacting large scale systems
communication construction still depends communication network much like romans used face face meetings paper surprisingly situation identified inhibitor increasing productivity source miscommunication rework avoidable accidents paper present holonic construction management hcm model allowing inclusion multitype holons organized resource clusters well flowing construction material carrying critical information hcm successfully tested provide smooth interface five different types holons equipment human laborer operator material three dimensional space information supply logistics results also illustrate potential hcm integrate many information communication technology ict applications resilient construction environment electronic designs turned physical products results initial site observations well safety statistics used identify important problem areas comparative work studies provided means measure differences performance traditional hcm enhanced approaches analysis field study results highlighted effectiveness key element hcm creation new communication corridors previously disconnected production units holon hardware testing field conditions highlighted difficulties embedding modern ict systems rugged environment construction well human responses changes finally successful realization hcm rebar supply management emphasized need reevaluation traditional contractual relationships large gains benefit participants evenly american society civil engineers
communicators motivated strategic self presentation selectively underreport negative content describing impressions individuals stereotypes groups particularly targets view ambivalently respect warmth competence communicators avoid overtly inaccurate descriptions preferring omit negative information emphasize positive information mixed individual targets study public audiences communicators increasingly prefer negativity omission complete accuracy study process driven self presentation concerns study moderated bidimensional ambivalence similarly extension princeton trilogy studies reported stereotypes ethnic national outgroups systematically omitted negative dimensions years anti prejudice norms intensified neutral positive stereotype dimensions remained constant study multiple assessment methods confirm stereotyping omission phenomenon study implications negativity omission innuendo stereotype stagnation discussed
communities practice cops received significant attention within variety literatures remain largely ignorant potential purposefully created cops global organisations context challenge likely convincing masters wenger merits joining conversation practice distance thus making willingness exchange key quality longevity community posed question would busy dispersed knowledgeable professionals want join participate deliberately organised cop year collaborative action study allowed observe cop membership close range conclude autonomy competence belonging underscore participation production diffusion innovative problem solving practice beyond cop study inform organisations contemplating similar interventions also serves basis investigation theory building organized cops research community elsevier ltd apm ipma rights reserved
comparative analysis material criteria embedded building sustainability assessment tools performed material related issues identified classified summarized framework triple bottom line sustainability environment economy society used examine material assessment criteria evaluation parameters descriptions material criteria evaluated identify current features weaknesses balanced material assessments sustainable development criteria showed significant differences scopes covering social economic aspects beyond environmental aspect comprehensive sustainability assessment purposes essential adequate attention paid three dimensions finally paper proposes indicators sustainable material assessment analysis material related items
compared conventional electrical machines permanent magnet machines experience higher efficiency higher power weight ratio simpler construction paper new three slot three phase four pole rare earth radial flux variable speed electrical generator proposed designed using finite element technique fet investigated topology soft magnetic material rotor placed pole faces rectangular high energy magnets air gap flux density distribution close sinusoidal achieved curving faces rotor soft magnetic pieces steady state characteristics different rotational speeds loading conditions addressed compared basically slotted electrical machines suffer cogging torque cogging torque generator predicted compared rated value machine windings located flat slots short ends therefore adds improvements efficiency power weight ratio operational performance cost active material obtained output operational performance characteristics generator along acceptable peak value cogging torque demonstrate success topology effectiveness design methodology elsevier ltd rights reserved
compared different types renewable energies wind energy fastest annual growing rate last decade hence employing framework based numerical algorithms optimal design electrical generator especially adopted wind power systems great challenge electrical systems recently rigid structure high torque density lower mass flux switching permanent magnet fspm generators attracted much interest capable supplementing conventional permanent magnet synchronous generators paper new analytical hierarchy process ahp approach proposed multi objective optimization design fspm generator carry optimization trade offs considered among conflicting targets cost mass electromagnetic performance finite element method numerical results experimentally validated means prototype used assess required data optimization optimal solutions given ahp method compared solutions obtained using different classical optimization methods results showed ahp approach gives best solution respect earlier designs also respect conventional optimization methods confirming effectiveness used optimal design electrical machines copyright john wiley sons ltd
compared full terms preterm individuals risk infancy adulthood developing internalizing symptoms early maternal interactive behavior especially maternal sensitivity found resilience factor developmental outcome preterm children present longitudinal study aimed examining whether early interactive parenting behaviors long term impact internalizing symptoms preterm born young adolescents total sample preterm full term children participated year follow study maternal interactive behavior assessed mother infant interaction infant months old years internalizing symptoms assessed child behavior checklist cbcl hierarchical regression analyses revealed interaction groups preterm full term maternal sensitivity months significantly explained cbcl internalizing symptoms years beta specifically although prematurity related internalizing problems preterm children higher maternal sensitivity differ full term born peers cbcl internalizing problems domain results suggest maternal sensitivity long term resilience factor preventing development internalizing problems early adolescence preterm individuals
compared traditional integer order pid controller fractional order pid controller expand range parameters control controlled objects flexibly become one research focuses control field recent years directing problem easy model parameters nonlinear fractional order pid controller determined paper presents new adaptive particle swarm optimization algorithm named ylpso conduct automatic setting parameters fractional order pid controller algorithm mainly adopting strategies adaptive dynamic weight asynchronization adjustment learning factors realizes ability intensifying algorithm convergence global optimum balancing global searching performance local searching performance pso algorithm simulation results show compared differential evolution algorithm standard particle swarm optimization algorithm ylpso control parameter optimizing effect better algorithm put forward paper provides new reference combination intelligent optimization algorithm nonlinear fractional order controller
compared vertical photogrammtry oblique photogrammetry radically different images acquired sensor big yaw pitch roll angles image matching vital step core problem oblique low altitude photogrammetric process among popular oblique images matching methods currently sift asift many affine invariant feature based approaches mainly used computer vision methods unsuitable requiring evenly distributed corresponding points high efficiency simultaneously oblique photogrammetry paper present oblique low altitude images matching approach using robust perspective invariant features firstly homography matrix estimated corresponding points obtained top pyramid images matching several projective simulation images matching implemented sub pixel harris corners descriptors shape perspective transforming basis homography matrix finally error gross error matched points excluded epipolar geometry ransac algorithm back projection constraint experimental results show proposed approach achieve excellent performances oblique low altitude images matching common methods including sift surf proposed approach significantly improve computational efficiency compared asift affine surf
compensating frequency offset transmitter receiver lasers major challenge coherent optical receivers necessitates use carrier phase recovery compensation circuitry receiver end capable tracking large frequency offsets laser linewidths propose frequency detector capable detecting frequency offsets mhz mhz proposed frequency detector designed bicmos technology design verified gbps qpsk gbps qpsk signals using circuit simulations gbps low power analog domain qpsk receiver consisting proposed frequency detector consumes power receiver capable working transmitter receiver lasers upto khz linewidth mhz frequency offset
complete transposition great arteries tga frequent cyanotic heart defect diagnosed neonates however exact etiology tga unknown aim present study assess association tga pathogenesis single nucleotide polymorphisms snps dna methyltransferases dnmts chinese children genotyped snps dnmt dnmta patients complete tga healthy children statistical analysis performed explore association snps complete tga susceptibility compared genotypes heterozygous genotype correlated decreased risk complete tga codominant dominant overdominant models contrast genotype correlated higher risk tga recessive model compared genotypes furthermore tgc tgt cgc cgt haplotypes dnmt differ significantly two groups whereas frequency tac haplotype lower case group significant differences frequencies haplotypes dnmta found two groups furthermore logistic regression showed sex snp two independent risk factors complete tga overall genotype snp dnmt might decrease risk complete tga pathogenesis southern chinese population elsevier rights reserved
complex information processing systems example quantum circuits cryptographic protocols multi player games naturally described networks composed basic information processing systems modular analysis systems requires mathematical model systems closed composition network objects object type propose model call corresponding systems causal boxes causal boxes capture superpositions causal structures messages sent causal box superposition different orders superposition sent box box furthermore causal boxes model systems whose behavior depends time instantiating abstract cryptography framework causal boxes obtain first composable security framework handle arbitrary quantum protocols relativistic protocols
complex networks heterogeneous relational data sets nontrivial substructures statistical properties typically represented graphs consisting vertices edges analysis intricate structure relevant many areas science commerce data sets may reach sizes require distributed storage processing describe compare programming models distributed computing focus graph algorithms large scale complex network analysis four frameworks graphlab apache giraph giraph apache flink used implement algorithms representative problems connected components community detection pagerank clustering coefficients implementations executed computer cluster evaluate frameworks suitability practice compare performance single machine shared memory parallel network analysis package networkit distributed frameworks graphlab apache giraph generally show best performance experiments cluster eight computers running apache giraph enables analysis network billion edges large single machine type however networks fit memory one machine performance shared memory parallel implementation usually far better distributed ones study provides experimental evidence selecting appropriate framework depending task data volume
complex older patients represent half acute public hospital admissions australia people dementia classic example complex older patients identified higher rates hospital acquired complications complications contribute poorer patient outcomes increase length stay cost hospitals care older people dementia complex attributed cognitive response hospitalised limited ability self care lack nursing engagement family caregiver registered nurses offer simultaneous assessment intervention prevent mitigate hospital acquired complications however known demand nursing care exceeds supply care prioritised according acute medical need consequently basic essential nursing care activities patient mobility communication skin care hydration nutrition implicitly rationed paper offers theoretical proposition failure maintain conceptual framework indicate implicit care rationing nurses care rationing contributes functional cognitive decline complex older patients contributes higher rates hospital acquired complications four key hospital acquired complications pressure injuries pneumonia urinary tract infections delirium proposed measurable indicators failure maintain hospital focus throughput constrains nurses privilege predictable solvable medically related procedures processes lead efficient discharge patient mobility communication skin care hydration nutrition privileging also known implicit rationing theoretically physiologically associated rise incidence complications pressure injuries pneumonia urinary tract infection delirium complex older patients including dementia higher risk complications therefore higher delivery prophylactic intervention higher care needs failure maintain offers conceptual framework inclusive sensitive vulnerable population implicit rationing occurring likely contributes functional cognitive decline complex older patients hospital acquired complications however lack patient functional ability data admission discharge hospitalised patients lack usable ward hospital level nurse staffing workload data makes difficult monitor understand improve quality care current research fields acute geriatrics nursing work environments show promise enabling multidisciplinary team communication facilitating clinical autonomy provide patient focussed care avoid failing maintain research field acute geriatrics understand act risk modification role nurses including controlling nurse staffing work environment variables intervention studies research field nurse sensitive outcomes incorporate different profile complex older patients including age brackets functional ability variables studies clinically nursing work environments designed recognise different profile complex older patients adapting practices privilege mobility hydration nutrition skin care communication midst acute care interventions elsevier ltd rights reserved
component deployment combinatorial optimisation problem software engineering aims finding best allocation software components hardware resources order optimise quality attributes reliability problem often constrained limited hardware resources communication network may connect certain resources owing non linear nature reliability function current optimisation methods focused mainly heuristic metaheuristic algorithms approximate methods find near optimal solutions reasonable amount time paper present mixed integer linear programming milp formulation component deployment problem design set experiments compare milp solver methods previously used solve problem results show milp solver efficient finding feasible solutions even methods fail prove infeasibility feasible solutions exist
composing queries evidently tedious task particularly true graph queries typically complex prone errors compounded fact graph schemas missing loose helpful query formulation despite great success query formulation aids particular automatic query completion graph query autocompletion received much less research attention paper propose novel framework subgraph query autocompletion called autog given initial query user preference input autog returns ranked query suggestions output users may choose query iteratively apply autog compose queries novelties autog follows first formalize query composition second propose increment query logical units called prime features frequent subgraphs constructed smaller prime features ways third propose algorithms rank candidate suggestions fourth propose novel index called feature dag fdag optimize ranking study query suggestion quality simulations real users conduct extensive performance evaluation results show query suggestions useful saved roughly users mouse clicks autog returns suggestions shortly large variety parameter settings
composite lymphomas consist distinct lymphomas occurring single anatomical site simultaneously different sites composed combination cell non hodgkin lymphoma nhl cell nhl hodgkin lymphoma cases composite lymphomas lymphomas extremely rare reports literature report case year old man triple composite lymphoma single lymph node consisting small lymphocytic lymphoma follicular lymphoma mantle cell lymphoma situ patient received multiple courses chemotherapy autologous stem cell transplant resulted complete remission years stem cell transplant developed classical unique case knowledge first report patient triple composite lymphoma consisting small mature cell nhls subsequently developed fourth lymphoma
comprehensive models targeting development eating disorders eds males often employ sociocultural perspective empathize importance body dissatisfaction illuminate psychological factors contributing development pathology propose mediator model disturbed eating compensatory behavior decb men model suggests emotion dysregulation susceptibility body related cognitive distortions thought shape fusion tsf mediate relationship decb based data cross sectional online survey tested model non clinical community sample young men years found significant positive association decb accounting participant body mass index bmi age depressive symptoms tsf partially mediated relationship decb detect corresponding effect emotion dysregulation based findings concluded tsf describes specific distorted cognitions respect one body triggered fattening forbidden food contributes pathological eating body related behavior men dissatisfied body suggest tsf included etiological models relevant aspect cognitive information processing emotional behavioral consequences elsevier ireland ltd rights reserved
computational fluid dynamic cfd calculations geometrically complex domains porous media require high geometric discretisation accurately capturing tested physical phenomena moreover considering large area analysing local effects necessary deploy multi scale approach memory intensive time consuming hence type analysis must conducted high performance parallel computing infrastructure paper coupling two different scales based navier stokes equations darcy law described followed generation complex geometries discretisation numerical treatment subsequently necessary parallelisation techniques rather specific tool capable retrieving data supercomputing servers visualising computation runtime situ described advantages possible drawbacks approach together preliminary results sensitivity analyses discussed detail elsevier ltd rights reserved
computational grids established intention providing shared access hardware software based resources special reference increased computational capabilities fault tolerance one important issues faced computational grids main contribution survey creation extended classification problems incur computational grid environments proposed classification help researchers developers maintainers grids understand types issues anticipated moreover different types problems omission interaction timing related identified need handled various layers computational grid survey analysis examination also performed pertaining fault tolerance fault detection mechanisms conclusion dependable reliable grid established emphasis fault identification moreover survey reveals adaptive intelligent fault identification tolerance techniques improve dependability grid working environments
computational micromechanical studies effect nanostructuring nanoengineering interfaces phase grain boundaries materials mechanical properties strength materials potential interface nanostructuring enhance materials properties reviewed several groups materials composites nanocomposites nanocrystalline metals wood considered view effect nanostructured interfaces properties structures various nanostructured interfaces protein structures mineral bridges biopolymers nacre microfibrils wood pores interphases nanoparticles fiber matrix interfaces polymer fiber reinforced composites nanocomposites dislocations precipitates grain boundaries nanocrystalline metals methods modeling discussed concluded nanostructuring interfaces phase boundaries powerful tool controlling material deformation strength behavior allows enhance mechanical properties strength materials heterogeneous interfaces low stiffness leading localization deformation nanoreinforcements oriented normally main reinforcing elements ensure highest damage resistance materials elsevier ltd rights reserved
computational simulation tools become critical components supporting learning well research science engineering one objective tools help students develop deeper conceptual understanding difficult concepts explanatory sequential mix method design study characterizes influence use computational tool called gibbs students understanding representation core concepts thermodynamics participants included sophomore engineering students large midwestern university enrolled course entitled thermodynamics materials first phase quantitative results examined students conceptual understanding exposed computational tool part laboratory session second phase qualitative evaluation characterized nature students representational forms way used results quantitative study revealed positive gains students conceptual understanding majority concepts tested addition insight gained qualitative analysis identified students representational systems used support conceptual understanding thermodynamics materials concepts
computationally intensive digital signal processing dsp systems sometimes real time requirements beyond programmable processor platform solutions consisting risc dsp processors achieve addition field programmable gate array fpga components platforms provides configurable hardware resource increased parallelism levels allow large computational rates techniques implement circuit architectures signal flow graph sfg algorithm expression produce highly efficient processor implementations applying folding transformations produces implementations hardware resource usage reduced possible expense throughput paper new development methodology presented analyses sfg algorithm suggest appropriate folding techniques characterizing different folding techniques template circuit architecture created early design process alter throughout remainder implementation process retiming techniques applied algorithm sfg produces properly timed implementation template applying methodology architectural exploration quickly efficiently performed generate set implementations implementation space best meet constraints system applied normalised lattice filter design example results demonstrate high savings fpga resource usage little reduction real time performance demonstrating implementation advantage employing methodology
computer networks consist several assets hardware software data sources assets often vulnerabilities exploited attackers violate security policies network considering limited budget network administrator analyze prioritize vulnerabilities able efficiently protect network mitigating risky ones far several security parameters offered analyze security risks network security administrator perspective major drawback methods consider attacker motivation depending motivation potential attackers different attack path may selected network security compromise attacker motivation key factor predicting attacker behavior paper attacker motivation considered process security risk analysis network administrators able analyze security risks accurately proposed method applied network results compared novel works area experimental results show network administrator able precisely predict behavior attackers apply countermeasures efficiently
computer numerical control machine tool typical complex product related multidisciplinary fields complex structure high performance requirements difficult identify overall optimal solution machine tool structure multiple objectives new integrated multidisciplinary design optimization method proposed using latin hypercube sampling kriging approximate model multi objective genetic algorithm design space parametric model built choosing appropriate design variables value ranges samples design space generated optimal latin hypercube method design variable contributions design performance discussed aiding designer judgments kriging model built using polynomial approximation according response outputs samples multidisciplinary design model established based three optimization objectives setting mass optimum deformation first order natural frequency two constraints second order natural frequency third order natural frequency optimal solution identified using multi objective genetic algorithm proposed method applied multidisciplinary optimization case study typical computer numerical control machine tool optimal solution mass decreases first order natural frequency increases contrast original solution
computer programming courses important specialized courses computer science teaching effects courses closely related students learning subjective initiative article took programming course example proposed set teaching strategies promote students learning initiative bank programming exercises hides programming knowledge designed integrated online judge system theory teaching organized around students programming practice like idea flipped classroom four special time nodes course study pointed corresponding measures taken continuously stimulate students programming initiative practice proved teaching strategies well mobilize enthusiasm students finally receive good teaching effects
computer programming learning requires declarative procedural knowledge novice learners acquire programming declarative knowledge via lectures tutorials self assessment cognitive overload within programming learning materials one several learning barriers self assessing important assist learners identify misconceptions encourage correct construction knowledge self test questions stq solutions print common learning methods used typical programming learning environment comparatively self assessment object sao type learning object used examine usefulness order impart declarative knowledge one hundred three foundation engineering students enrolled programming module took part study randomly assigned two groups control group used stq experimental group used sao programming lab seven teaching weeks post test supporting survey results suggest sao able support programming learning mitigate learning difficulties addressed study authors published elsevier ltd
computer programming remains difficult discipline teach learning help improve student engagement outcomes offerings designed teach programming university context rudimentary compared publicly available sites code academy paper describes nooblab learning platform teaching programming environment provides complete suite features surpassing prior work successfully used number undergraduate modules improve student outcomes satisfaction inform pedagogy
computer science students usually enthusiastic learning artificial intelligence due possibility developing computer games incorporate behaviors scenario search algorithms fundamental subject broad variety games implementing deterministic games varying tic tac toe chess games commonly approaches used teach considering perspective game playing however stochastic games usually fun play much explored learning process approaches learning include developing searching algorithms compete approaches relevant engaging lack environment features algorithm design benchmarking capabilities address issue present cap environment support learning process analysis adversarial search algorithms using stochastic card game conducted pilot experiment computer science students developed different adversarial search algorithms hanafuda traditional japanese card game
computer vision based human activity recognition har become famous days due applications various fields smart home healthcare elderly people video based activity recognition system basically many goals react based people behavior allows systems proactively assist tasks novel approach proposed work depth video based human activity recognition using joint based motion features depth body shapes deep belief network dbn depth video different body parts human activities segmented first means trained random forest motion features representing magnitude direction joint next frame extracted finally features applied training dbn used recognition later proposed har approach showed superior performance conventional approaches private public datasets indicating prominent approach practical applications smartly controlled environments
computer aided design cad models thin walled solids sheet metal plastic parts often reduced dimensionally corresponding midsurfaces quicker fairly accurate results computer aided engineering cae analysis computation midsurface still time consuming mostly manual task due lack robust automated techniques existing techniques work final shape typically form boundary representation rep complex reps make hard detect subshapes midsurface patches computed joined forcing usage hard coded heuristic rules developed case case basis midsurface failures manifest form gaps overlaps nonmimicking input model etc take hours even days correct research presented proposes address problems leveraging feature information available modern cad models effectively using techniques like simplification abstraction decomposition proposed approach first irrelevant features identified removed input fbcad model compute simplified gross shape remaining features undergo abstraction transform corresponding generic loft equivalents profile guide curve model decomposed cellular bodies graph populated cellular bodies nodes fully overlappingsurface interfaces edges nodes classified midsurface patch generating nodes called solid cells scells interaction resolving nodes interface cells icells scell midsurface patch generated either offset sweeping midcurve owner loft feature profile along guide curve midsurface patches connected icells generic manner thus resulting wellconnected midsurface minimum failures output midsurface validated topologically correctness end paper real life parts used demonstrate efficacy proposed approach
computer based assessments complex problem solving performance often take place group settings like classrooms computer laboratories computer based procedures provide excellent opportunity examine setting effects might occur participants tested non group session online time place choosing purpose teacher students randomly assigned one two settings individual online condition computer laboratory group condition strong factorial measurement invariance evidenced participants performed significantly better individual online condition group condition knowledge acquisition knowledge application worse performance group setting compared individual setting could neither explained exploration time ndr time task internal experimental design validity strengthens conclusion setting related differences cognitive ability testing negligible noteworthy elsevier ltd rights reserved
computers leading technology century programming development software thus fundamental activity many people engaged worldwide therefore programming courses included part curriculum courses students primarily introduced language features traditionally students practice applying acquired knowledge solve logically straightforward problems giving less scope programming skills paper focuses application coding standards coding techniques debugging code review refactoring code optimization test driven programming pair programming based learning master programming language features also integrated approach gain problem solving programming skills subject introduced first year course students without smaller amount background experience computer programming taking consideration activities like programming designed activities enhanced learning ability problem solving skills programming skills debugging skills
computing education researchers become increasingly interested leveraging log data automatically collected within computer programming environments order understand students learning processes tailor instruction student needs data students programming activities positively correlated learning outcomes data tell part story another part story lies students social activities according social learning theory also predictive students learning outcomes order gain insight computing students learning processes influence learning outcomes present empirical study explores interplay students social activities programming activities course outcomes early computing course analyzing log data collected programming environment augmented social networking style activity stream found answers questions posed activity stream positively correlated students ability make programming progress eventual success course based findings present recommendations design pedagogical environments support social programming process
computing recently introduced core subject british schools meaning children need learn computer programming teachers prepared able deliver new curriculum many feel confident teaching formal background computer science also learning programme children need correct environment support succeed paper presents turinglab environment assist teachers delivering practical elements computing curriculum also proving engaging challenging children teachers create programming challenges pupils see progressing struggling completion challenges students undertake challenges engaging environment displays graphical output code assists understanding errors may encounter turinglab used teach children programme number volunteer led coding clubs children engaged well turinglab volunteers acted teachers sessions found turinglab extremely valuable educational tool
concept map model method creates domain model identifying relationship concepts course contents study presents adaptive intelligent web based learning system called opcomits object oriented programming tutor using concept map model opcomits free domain model regulated expert course uses concept map model regulate topic hierarchy measure student knowledge topic stimulate learning employing concept map model structures course provides environment lecturer arrange chapters topics concepts prerequisite relationships concepts thus offers adaptive effective learning environment measuring level student knowledge topic offering reinforcing feedback diagnosing students weaknesses directing related chapter topic domain revisions evaluate effectiveness proposed approach experiment conducted computer programming department object oriented programming course experimental results found opcomits contributed academic success students using students exhibited much better learning used conventional learning system wiley periodicals inc
concerns adverse effects air pollution children health rapidly rising however effects air pollution childhood growth remain poorly studied investigated association prenatal postnatal exposure children weight birth months age birth cohort study evaluated mother child pairs south korea children weight measured birth six months average levels children exposure particulate matter diameter estimated pregnancy period visit months age exposure pregnancy lowered children weight months exposure seven months negatively affected weight months repeated measures weight months revealed negative association postnatal exposure children weight children continuously exposed high level pregnancy months age weight scores times lower children constantly exposed lower level period furthermore growth vulnerable exposure children birth weight air pollution may delay growth early childhood exposure air pollution may harmful children birth weight low elsevier ltd rights reserved
conclusions purpose set describe modern day management lymphocytic hypophysitis respect diagnosis treatment long term endocrine visual outcomes deliberately included patients clinical diagnosis compared histological diagnosis following surgery methods multi centre observational study performed twenty two patients included studied mean follow period years range years results patients presented headache visual field disturbances combination symptoms time lag onset symptoms diagnosis months approximately third patients respectively two thirds patients diagnosed based clinical biochemical radiological findings surgical cohort statistically likely presented larger lesions suprasellar extension greater visual field defects follow improvement headaches visual symptoms rate hypopituitarism reflected need going pituitary hormone replacement persisted year follow significant difference medically surgically managed cohorts terms ongoing symptomatology need pituitary hormone replacement modern era patients diagnosed non surgical means managed medically remains significant time lag onset symptoms eventual diagnosis despite considerable morbidity attached overall prognosis good
conclusions delay abr caeps wave latencies children type indicates abnormality neural conduction patients duration greater effect auditory function control background diabetes mellitus common endocrine metabolic disorder evoked potentials offer possibility perform functional evaluation neural pathways central nervous system objectives investigate effect type diabetes mellitus tdm auditory brain stem response abr cortical evoked potentials caeps method study included two groups control group consisted healthy children normal peripheral hearing study group gii consisted children type basic audiological evaluation abr caeps done groups results delayed absolute latencies abr caeps waves found amplitudes showed significant difference groups positive correlation found abr wave latencies duration correlation found abr caeps glycated hemoglobin
concurrent data structures fast predictable performance critical importance harnessing power multicore processors ubiquitous although wait free objects whose operations complete bounded number steps devised two decades ago wait free objects deliver scalable high performance still rare paper present first wait free fifo queue based fetch add faa compare swap cas based non blocking algorithms may perform poorly due work wasted cas failures algorithms coordinate using faa guaranteed succeed principle perform better high contention along faa queue uses custom epoch based scheme reclaim memory architectures requires extra memory fences algorithm typical execution path empirical study new faa based wait free fifo queue high contention four different architectures many hardware threads shows outperforms prior queue designs lack wait free progress guarantee surprisingly highest level contention throughput queue often high microbenchmark performs faa result fast waitfree queue implementation useful practice multi core systems today believe design serve example construct fast wait free objects
conditional differential cryptanalysis nfsr based cryptosystems first proposed knellwolf asiacrypt successfully used attack reduced variants grain paper greatly improve conditional differential attacks grain following four aspects first new differential engine derived correctly track differential trails grain second propose new difference searching strategy serves find suitable differences conditional differential attack given reduced variant grain third highly saving condition imposing strategy presented last propose bias increasing strategy particular improvements difference searching strategy condition imposing strategy crucial mount conditional differential attacks variants grain rounds shown improved conditional differential attacks could retrieve distinct secret key expressions round grain could retrieve distinct secret key expressions round grain attacks succeed constant probabilities thus far results best known reduced variants grain far number rounds attacked concerned
conducting polymers used many years coating materials corrosion however coated materials absorb water time resulting reduction resistivity anticorrosion properties study poly ethylpyrrole mpy mpy titanium dioxide tio nanocomposite films synthesized oxalic acid solution electrode chronoamperometric method modified electrodes characterized scanning electron microscopy energy dispersive ray analysis fourier transform infrared attenuated transmission reflectance electrochemical impedance spectroscopy eis tafel extrapolation techniques corrosion tests results obtained sodium chloride nacl solution tafel plots addition equivalent electrical circuit model mpy mpy tio nanocomposite films investigated nacl solution different time periods eis study polymer nanocomposite analyzed matlab program first time tina equivalent electrical circuits program used
configuration management practices allied quality management processes prove indispensable solution software development article presents case study company develops software public management implemented process configuration management associated changes process software quality management one discussed points article benefits remarkable decrease number requests fix problems software twelve months approximately time spent correct problems reduced another aspect associated software review inspection techniques conducted release tests allow problems software found test team getting customer although proposals conducted improve processes changes brought many benefits quality software
congenital heart disease chd one prevalent birth defects world however underlying molecular mechanism fully understood report increased chd susceptibility associated genetic polymorphisms novo nucleotide biosynthesis northern chinese population reported lower plasma folate levels nine tagsnps four genes gart atic mthfd shmt novo nucleotide biosynthesis sequenced sporadic chd patients controls two han chinese populations located north china shandong south china shanghai respectively six snps found significantly associated chds septation defects shandong population dataset none displayed significant association chds shanghai population dataset well combined dataset also showed minor allele gart reduced transcriptional activity displayed lower affinity unknown transcription factor demonstrating allele functional risk factor chd shandong population study indicates dysregulation novo nucleotide biosynthesis pathway may conditionally contribute chd pathogenesis northern chinese
congenital hypothyroidism fetal goiter rare condition associated severe possibly preventable intrauterine postnatal complications ultrasound examination weeks pregnancy enables prenatal diagnosis early treatment due limited transplacental transport thyroid hormones direct intrauterine treatment needed far reports fetal goitrous hypothyroidism published consensus adequate management exists present case severe fetal goitrous hypothyroidism diagnosed gestational weeks treated sequential intra amniotic administration thyroxin treatment resulted significant goiter reduction normalization amniotic hormone levels enabled uncomplicated vaginal delivery term current knowledge regarding prenatal diagnosis intrauterine treatment unified applied within case recommendation clinical practice provided report
congenital penile anomalies cpas among common human birth defects reports cpas include hypospadias chordee micropenis ambiguous genitalia risen sharply recent decades causes malformations rarely identified genetic anomalies environmental factors antiandrogenic estrogenic endocrine disrupting chemicals edcs suspected cause cpas however little known temporal window sensitivity edcs tissue specific roles downstream targets androgen receptor external genitalia show full spectrum cpas produced disrupting different developmental stages specific cell types mouse genital tubercle inactivation narrow window prenatal development results hypospadias chordee whereas earlier disruptions cause ambiguous genitalia later disruptions cause micropenis neonatal phase penile development controlled balance estrogen receptor alpha activity either inhibition androgen augmentation estrogen signaling induce micropenis alpha opposite effects cell division apoptosis regulation hedgehog fibroblast growth factor bone morphogenetic protein wnt signaling genital tubercle identify indian hedgehog ihh novel downstream target external genitalia show conditional deletion ihh inhibits penile masculinization studies reveal previously unidentified cellular molecular mechanisms antiandrogenic estrogenic signals induce penile malformations demonstrate timing endocrine disruption determine type cpa
connections present electrical circuits come many shapes materials share one common trait involved directly indirectly many grid faults integrity power system grids plays fundamental role smart grid context monitoring equipment assets contributes significantly reliability electric power systems article aims relate causes connection degradation well describe system continuous monitoring connections
consider tree nodes weight drawn sigma article study problem supporting various path queries tree path counting query asks number nodes query path whose weights query range path reporting query requires report nodes path median query asks median weight path two given nodes path selection query returns smallest weight design succinct data structures encode using sigma bits space support path counting queries sigma time path reporting queries occ sigma time path median path selection queries sigma sigma time entropy multiset weights nodes occ size output results greatly improve best known data structures chazelle krizanc also match lower bounds path counting median selection queries patrascu jorgensen larsen sigma omega polylog
considered cooperation container truck quayside container crane container terminal paper constructs model quay cranes operation trucks scheduling problem container terminal hybrid intelligence swarm algorithm combined particle swarm optimization algorithm pso artificial fish swarm algorithm afsa proposed hybrid algorithm pso afsa adopt particle swarm optimization algorithm produce diverse original paths optimization choice nodes set problem use afsa preying chasing behavior improved ability pso avoid premature proposed algorithm effectiveness quick convergence feasibility solving problem results stimulation show scheduling operation efficiency container terminal improved optimized
considering condition regarding discipline construction chinese university paper proposes measures enhance level discipline construction chinese universities contains refine characteristics improve advantages disciplines construction first class basic disciplines strengthen cross disciplinary promote discipline international construction innovate discipline construction management operation mechanism etc
considering wood currently used construction domain may observed possesses good strengths reduced modules elasticity drawback may prevented creating structures rigid nodes using hybrid built cross sections structural elements paper consists numerical analysis timber frame rigid nodes assuming built cross sections structural elements made four chords cross sectional dimensions columns two chords beams analyzing type structures considering equivalent cross sections properties structural elements real phenomena may covered since consider elastic characteristics wood resulting different stress distribution structural elements analysis structure considering real solid cross sections elastic properties wood using specialized software leads laborious work high number finite elements thereby two step analysis proposed first one consists solving spatial timber frame bar type finite elements elastic properties parallel grain provided design codes second step intermediary node detached loaded internal forces obtained first step considering elastic parameters wood using solid type finite elements currently design process first step performed two step analysis aims compare results obtained using strength materials methods relieving necessary corrections case one step design process
construction industry influences environment great deal using different resources efficient use resources important sustainability considerations heavy consumption energy one reasons causing adverse impacts built environment interest sustainable construction growing worldwide green building systems used certify projects green buildings different countries systems similar approaches build sustainably highlight requirements related energy consumption significant emphasis one recognized green building certification systems leed addresses energy optimization green power site renewable energy much detail maximum credit points achieved energy atmosphere category leed however use leed countries difficult local conditions practices influential earning credentials study aims review practices energy atmosphere category leed new construction european countries analysis practices selected countries made based credit performances display variations depending local conditions expected practitioners countries benefit credit patterns providing improved insights site real applications authors published elsevier ltd
construction professionals agree building information modelling bim revolutionize architectural engineering construction aec industry impact felt project stakeholders including owners facility managers statistics show many owners stakeholders perceive bim technology make project delivery efficient allows project information fully integrated future owners expected demand use bim prevent budget time project delivery however preparing contribution level implementation use bim varies widely across globe paper probes state bim alberta three points view current understanding implementation motivations driving use iii challenges hindering implementation findings paper extracted individual responses web based survey proposed professionals albertan aec industries
construction projects require effective planning management site equipment tower cranes heavily employed large scale construction projects thus incurring additional costs delays used inefficiently research aims optimize crane operations high rise buildings considering overlap space cranes look ahead planning lap employed perform daily operations planning provide reliable constraint free daily schedule crane operations simulation model performing metaheuristic optimization developed optimize near real time allocation cranes tasks lap schedule calculating crane movements three dimensional environment checking collisions lap simulation model tested case study project results show overlaps coupling lap optimization better reduce duration balance work demand study provides practitioners daily planning optimization process tool enhance crane operations american society civil engineers
construction projects usually encompass numerous disciplines requiring integration knowledge civil mechanical electrical engineering domains researchers contend integration construction knowledge experience early design phase would improve overall project performance domination tacit knowledge design phase building projects major source knowledge flow problems involved professionals therefore study intends explicate required mechanical electrical knowledge considered conceptual design phase green building project fulfil goal case study conducted specify entity required mechanical electrical knowledge primary method data collection observation furthermore study employs triangulation method order validate collected data results contain required mechanical electrical knowledge considered conceptual design phase green building project
constructivists memory argue memory capacity building representations past events generalized information store brigard synthese michaelian philos psychol view motivated memory errors discovered cognitive psychology little known neural mechanisms false memories produced recently using method call optogenetic false memory technique fame neuroscientists created false memories mice ramirez science paper examine constructivism fares light fame results aims two fold first argue errors found fame cognitive psychology similar behaviorally second constructivists able explain former since purport explain latter conclude fame studies reveal details mechanism false memories produced incompatible explanatory approach false memories favored constructivism
contact angles grain boundaries gbs based binder measured use special model alloys ultra coarse grained microstructure either low high carbon content low carbon sample contained significantly low angle contacts binder high carbon sample therefore wettability gbs liquid based binder noticeably worse high carbon sample low carbon sample established worse wettability gbs binders high carbon content sheds light mechanism binder drift sintering functionally graded cemented carbides containing high carbon surface layers elsevier rights reserved
contact behaviours touch shown influential channels nonverbal communication mothers infants existing research examined communicative roles maternal infant touch isolation mutual touch whereby touching behaviours occur simultaneously mothers infants yet examined present study designed investigate mutual touch face face interactions mothers month old fullterm low birth weight preterm vlbw preterm infants infants psychosocial risk objectives examine quantitative qualitative aspects touch employed mothers infants varied across normal periods still face procedure associated risk status mutual touch systematically coded using mother infant touch scale interactions found largely consist mutual touch one sided touch plus movement highlighting active touching pervasive mother infant interactions consistent literature period negatively affect amount mutual touch engaged mothers fullterm infants mothers infants psychosocial risk mothers vlbw preterm infants together results illuminate mothers infants participate shaping regulating interactions use touch underscore contribution examining influence birth status mutual touch elsevier inc rights reserved
context number systematic literature reviews mapping studies slrs covering numerous primary research studies various aspects agile software development asd exist objective aim paper provide overview slrs asd research topics software engineering researchers practitioners method followed tertiary study guidelines kitchenham find slrs published late december results found slrs focusing ten different asd research areas adoption methods practices human social aspects cmmi usability global software engineering gse organizational agility embedded systems software product line engineering number slrs asd topics similar software engineering topics general rise majority slrs applied standardized guidelines quality slrs asd topics found slightly higher journal publications conferences individuals institutions seem lead area spread authors institutions wide respect prior review recommendations significant progress noticed area connecting agile established domains usability cmmi gse considerable progress observed focusing management oriented approaches scrum sustaining asd different contexts embedded systems conclusion slrs asd studies rise cover variety asd aspects ranging early adoption issues newer applications asd product line engineering asd research benefit primary secondary studies evaluating benefits challenges asd methods agile hybrids large scale setups sustainability motivation teamwork project management well fresh review empirical studies asd cover period post elsevier rights reserved
context objective many researchers suggested aspirin prevents migraines however evidence unclear aim study analyze available evidence effect aspirin migraine prophylactic design setting systematic review conducted pontificia universidade catalica parana brazil university sao paulo brazil methods performed electronic searches databases medline pubmed embase web science world health organization central opengrey also searched manually interventional studies published april compared effects aspirin control adults two authors independently extracted data publication population recruited intervention aspirin dosage follow combined treatment main outcomes frequency severity duration migraine evaluated quality studies using cochrane risk bias tool results search retrieved references met selection criteria systematic review total population participants years old men dosage varied day across studies risk bias generally low unclear outcome studies included reported significant reduction frequency migraine reduced aspirin dosage least day conclusion aspirin reduce frequency migraines however optimal dosage unclear
context information shapes spin states individual asteroids important study whole asteroid population asteroids main belt shape models available reconstructed disk integrated photometry lightcurve inversion method aims want significantly enlarge current sample similar available asteroid models methods use lightcurve inversion method derive new shape models spin states asteroids sparse time photometry compiled lowell photometric database speed time consuming process scanning period parameter space use convex shape models use distributed computing project asteroids home running berkeley open infrastructure network computing boinc platform way period search interval divided hundreds smaller intervals intervals scanned separately different volunteers joined together also use alternative faster approach searching best lit period using model triaxial ellipsoid independently confirm periods found convex models also find rotation periods asteroids convex model approach gives many solutions results analysis lowell photometric data first numbered asteroids derived new models almost doubles number available models tested reliability results comparing models derived purely lowell data based dense lightcurves found rate false positive solutions low also present updated plots distribution spin obliquities pole ecliptic longitudes confirm previous findings non uniform distribution spin axes however models reconstructed noisy sparse data heavily biased towards elongated bodies high lightcurve amplitudes conclusions lowell photometric database rich reliable source information spin states asteroids expect hundreds asteroid models asteroids numbers larger derivable data set models able reconstructed lowell data merged photometry
context prolonged use benzodiazepines increases risk addiction impact disease use health services older adults known objective examine association benzodiazepine dependence use health services older adults quebec methodology data comes survey conducted quebec representative sample elderly benzodiazepine consumption community benzodiazepine dependence defined according criteria diagnostic statistical manual mental disorders fourth revised edition use health services measured incidence consultations health professionals period months results seniors consumed average daily dose diazepam equivalent average days prevalence benzodiazepine dependence estimated dependence increases likelihood consulting specialist odds ratio confidence interval visits health professionals frontline significant conclusion results study suggest proportion seniors become addicted benzodiazepines use health services condition important need develop programs improve quality benzodiazepine use population
context agile approaches alternative organizations developing software particularly develop web applications besides cmmi capability maturity model integration models well established approaches focused assessing maturity organization develops software web engineering field software engineering responsible analyzing studying specific characteristics web suitability agile approach help organizations reach certain cmmi maturity level web environments interesting able keep ability quickly react adapt changes long development processes get mature objective paper responds whether feasible organization developing web systems achieve certain maturity level cmmi dev model using agile methods method proposal analyzed means systematic literature review relevant approaches field defining characterization schema order compare introduce current state art results results achieved systematic literature review presented analyzed compared defined schema extracting relevant conclusions different dimensions problem compatibility compliance experience maturity web conclusion concluded although definition agile approach meet different cmmi maturity levels goals could possible organization developing web systems still lack detailed studies analysis field elsevier rights reserved
context alpha blockers abs alpha reductase inhibitors established role treating male lower urinary tract symptoms luts attributed benign prostatic hyperplasia bph recently newer drugs shown promise indication objective assess comparative effectiveness adverse effects aes newer drugs treat luts attributed bph systematic review meta analysis evidence acquisition ovid medline cochrane central register controlled trials ovid embase bibliographic databases june hand searches references relevant studies eligible studies included randomized controlled trials published english newer abs antimuscarinics beta adrenoceptor agonist phosphodiesterase type inhibitors combination therapy one medications active comparator observational studies agents duration reported aes also included evidence synthesis synthesized evidence randomized controlled trials well five observational studies based improvement mean international prostate symptom score quality life scores effectiveness newer abs different older abs moderate strength evidence soe aes low soe antimuscarinics combination therapy similar outcomes monotherapy moderate soe often aes phosphodiesterase type inhibitors alone combination abs similar inferior outcomes abs alone evidence insufficient beta adrenoceptor agonist newer agents evidence generally insufficient assess long term efficacy prevention symptom progression aes conclusions none drugs drug combinations newly used treat luts attributed bph showed outcomes superior traditional treatment given lack superior outcomes studies short time horizon less assurance safety current value treating luts attributable bph appears low patient summary paper reviewed evidence newer drugs treat men urinary problems attributable enlarged prostate wefound none new drugs better concern side effects european association urology published elsevier rights reserved
context newcomer industrial practitioner likely experience difficulties digesting large volumes knowledge software testing ideal world knowledge used industry education research based high quality evidence since decision made based single study secondary studies become essential presenting evidence according search secondary studies published area software testing since high number secondary studies important conduct review area provide overview research landscape area objective goal study systematically map classify secondary studies software testing propose tertiary studies serve summarizing indexes facilitate finding relevant information secondary studies thus supporting evidence based decision making given area software engineering research questions rqs investigate software testing specific areas types rqs investigated numbers trends citations secondary studies method conduct tertiary study use systematic mapping approach additionally contrast testing topics number google hits address general popularity testing topic study popular papers terms citations furthermore demonstrate practicality usefulness results mapping istqb foundation syllabus swebok provide implications practitioners testing educators researchers results systematic search voting process study pool included secondary studies area software testing among results following terms number secondary studies model based approach popular testing method web services popular system test sut regression testing popular testing phase quality secondary studies measured criteria set established community slowly increasing years analysis research questions raised studied pool secondary studies showed lack causality relationship type research questions situation needs improved community want advance scientific field among secondary studies found regular surveys receive significantly citations sms slrs conclusion despite large number secondary studies found many important areas software testing currently lack secondary studies test management role product risk testing human factors software testing beta testing testing exploratory testing testability test stopping criteria test environment development secondary studies areas important satisfying industrial educational needs software testing hand education material istqb foundation syllabus swebok could benefit inclusion latest research topics namely search based testing use cloud computing testing symbolic execution elsevier rights reserved
context constructing bespoke software development methodologies specific project situations become crucial need giving rise situational method engineering sme compared software engineering sme long way yet sme approaches especially deficient support modeling portability automation model driven development mdd effectively used addressing issues software engineering also considered promising approach resolving sme objective paper aims address shortcomings existing sme approaches introducing novel mdd approach specifically intended sme purposes uses pattern based approach model transformation method developing mdd approach sme requires modeling framework consisting modeling levels defined modeling software development methodologies transformation patterns also specified converting models one level next process defined applying framework transformations patterns real sme projects resulting mdd approach requires proper evaluation demonstrate applicability results framework semi automated process proposed adapt pattern based model transformation techniques application methodology models used sme transformation patterns implemented medini qvt model transformation tool along two supplementary method bases one mapping situational factors sme projects requirements mapping requirements method fragments method engineer produce methodology models using method bases executing transformation patterns via tool conclusion validity proposed approach assessed based special evaluation criteria also application real world project evaluation results indicate proposed approach addresses deficiencies existing approaches satisfies practicality requirements sme approaches elsevier rights reserved
context study report systematic mapping study sms domain specific languages dsls based automatic search including primary studies journals conferences workshops period objective main objective described work perform sms dsls better understand dsl research field identify research trends possible open issues set research questions inspired dsl survey paper published method conducted sms stages defining research questions conducting search screening classifying data extraction sms included candidate primary studies isi web science acm digital library primary studies classified screening results sms discusses two main research questions research space trends demographics literature within field dsls research questions subdivided several research sub questions results first research question clearly show dsl community focuses development new techniques methods rather investigating integrations dsls software engineering processes measuring effectiveness dsl approaches furthermore clear lack evaluation research amongst different dsl development phases attention needed regard domain analysis validation maintenance second research question revealed number publications remains stable increased years top cited papers venues mentioned well identifying active institutions carrying dsl research conclusion statistical findings regarding research questions paint interesting picture mainstreams dsl community well open issues researchers improve research future work elsevier rights reserved
context methods processes along tools support heart software engineering discipline however know often use method neither impacts software projects comparable manner software result lacking understanding methods affect software development objective article develops set concepts based practice concept philosophy sociology base describe software development social practice develop understanding methods application explains heterogeneity outcome practice understood opposed theory commonly agreed upon way acting acknowledged team method article applies concepts philosophy sociology social theory describe software development develops concepts method method usage results steps philosophical argumentation exemplified using published empirical research results article develops conceptual base understanding software development social epistemic practices defines methods practice patterns need related integrated existing development practice application method conceptualized development practice practice certain aspects aligned description method method always defines practice implication research industrial software development teaching indicated conclusion theoretical philosophical concepts allow explaining heterogeneity application software engineering methods line empirical research results elsevier rights reserved
context neurocognitive test scores often considered important aspect concussion management best use data clinicians must understand potential factors may influence baseline performance tests objective determine preexisting factors may influence performance immediate post concussion assessment cognitive test impact design cross sectional study setting research laboratory patients participants total national collegiate athletic association division collegiate student athletes main outcome measure determine neurocognitive functioning total symptom score baseline impact administered outcomes verbal memory visual memory visual motor speed reaction time total symptom score self report demographic section beginning impact used gather information concerning previous treatment headaches migraines psychiatric conditions diagnosis attention deficit hyperactivity disorder exposure previous strenuous exercise conducted multivariate analyses variance determine impact composite total symptom scores differed according preexisting factors results sex showed effect verbal memory visual motor speed reaction time women performing better men previous diagnosis attention deficit hyperactivity disorder affected visual motor speed previous treatment headaches migraines psychiatric condition diagnosis ofattention deficit hyperactivity disorder showed effects total symptom score strenuous exercise affect neurocogntive performance total symptom score conclusions based findings previous literature suggest many preexisting factors influence baseline neurocognitive data baseline testing important aspect concussion management sports medicine professionals cognizant factors developing concussion management protocols
context past years numerous studies investigated possible effect software engineers personalities may upon individual tasks teamwork led improved understanding relationship however analysis personality traits impact software development process still area investigation debate personality traits team climate also another factor also investigated given relationship software teams performance objective aim paper investigate software professionals personality associated team climate team performance method paper detail systematic literature review slr effect software engineers personality traits team climate software team performance results main findings include primary studies addressed relationship personality team performance without considering team climate findings showed team climate comprises wide range factors fall within fields management behavioral sciences studies used undergraduate students subjects surrogates software professionals conclusions findings slr would beneficial understanding personality assessment software development team members revealing traits personality taxonomy along measurement software development team working environment measurements would useful examining success failure possibilities software projects development processes general terms human factors performance elsevier rights reserved
context patients schizophrenia display abnormalities pitch discrimination non verbal tones revealed tone matching task tmt may lead deficits higher order cognitive functions clinical symptoms objectives conducted systematic review meta analysis pooling data tmt score differences patients schizophrenia healthy controls evaluate deficit effect size develop reliable knowledge pitch processing impairment pejorative impact method relevant publications identified systematic search pubmed embase databases excluded non relevant studies meta analysis effect size percent correct responses tmt expressed standardized mean difference smd results eighteen identified studies met eligibility criteria review included meta analysis meta analysis showed effect size percent correct response tmt patients controls large smd value value meta analysis showed moderate heterogeneity studies relationship tone matching impairment clinical symptoms schizophrenia remains heterogeneous across studies authors observed significant correlations tone matching performance number higher order cognitive abilities conclusion review meta analysis highlights large significant disturbance tone matching ability patients compared controls study basic auditory processing opens promising perspectives pathophysiological modelling disorder therapeutic issues elsevier rights reserved
context recent years seen increasing interest general theories software engineering academic fields theories aim explain predict key phenomena discipline objective present article proposes general theory software engineering labeled tarpit theory reference epigram alan perlis method integrative theory development approach employed develop tarpit theory four underlying theoretical fields languages automata cognitive architecture iii problem solving organization structure applicability explored three test cases results theory demonstrates explanatory predictive potential diverse set software engineering phenomena demonstrates capability explaining brooks law making predictions domain specific languages evaluating pros cons practice continuous integration conclusion presented theory appears capable explaining predicting wide range software engineering phenomena refinement application theory remains future work elsevier rights reserved
context several research efforts targeted support architecture centric development evolution software robotic systems last two decades objective aimed systematically identify classify existing solutions research progress directions influence architecture driven modeling development evolution robotic software research method used systematic mapping study sms method identifying analyzing peer reviewed papers review taxonomically classified existing research systematically mapped solutions frameworks notations evaluation methods highlight role software architecture robotic systems results conclusions identified eight themes support architectural solutions enable operations evolution iii development specific activities robotic software research area progressed object oriented component based service driven robotics representing different architectural models emerged overtime emerging solution cloud robotics exploits foundations service driven architectures support interconnected web robots results sms facilitate knowledge transfer benefiting researchers practitioners focused exploiting software architecture model develop evolve robotic systems elsevier inc rights reserved
context sunscreen lotions important protect skin outdoor exercise may interfere sweating objective measure effect water resistant sunscreens local sweat production men women exercising heat compare effects expected inhibition resulting use antiperspirant design randomized crossover study setting exercise heat ambient temperature degrees degrees dry bulb relative humidity controlled environment laboratory patients participants twenty physically active apparently healthy college students men age years height mass women age years height mass intervention sweat collection patches applied right left scapular regions participants performed exercise sessions consecutive days assigned skin treatments antiperspirant organic chemical sun filter sunscreen inorganic physical sun block sunscreen lotion randomly side session participants pedaled maximum heart rate minutes heat main outcome measure scapular localized sweat rate results baseline environmental exercise condition different among skin treatments scapular localized sweat rate lower antiperspirant treatment min confidence interval min inorganic physical sun block sunscreen treatment min min organic chemical sun filter sunscreen treatment min min lotion treatment min min conclusions inorganic physical sun block sunscreen hindered effective sweating extent antiperspirant whereas treatment organic chemical sun filter sunscreen different control treatment stage possible identify specific ingredient responsible effect
context thyroid hormones influence kidney function thereby might alter serum urate levels major risk factor gouty arthritis objective assess risk developing incident gout association hypothyroidism hyperthyroidism design retrospective population based case control analysis setting based clinical practice research datalink primary care research database patients identified adult patients diagnosis incident gout matched one control gout case terms age sex general practice calendar time years active history database main outcome measure used conditional logistic regression calculate odds ratios ors confidence intervals cis developing gout association hypo hyperthyroidism adjusted potential confounders results study population encompassed incident gout cases male number matched controls increased risk gout patients hypothyroidism adjusted gout compared hypothyroidism current short term treatment thyroid hormone replacement therapy associated adjusted gout compared treatment neither hyperthyroidism current treatment thyroid suppression therapy associated gout adjusted respectively conclusion large observational study provide evidence hypothyroidism hyperthyroidism irrespective treatment associated clinically relevant increased risk developing incident gout may exception among patients newly diagnosed treated hypothyroidism
context youth exposure explicit film violence sex linked adverse health outcomes serious public health concern motion picture association america mpaa rating system effectiveness reducing youth exposure harmful content questioned purpose determine mpaa rating system effectiveness screening explicit violence sex since system initiation introduction category also examine evidence less restrictive ratings time ratings creep design top grossing movies coded explicitness violent sexual content trends rating assignments content different rating categories since assessed results explicitness violent sexual content significantly increased following rating system initiation system differentiate violent content well sexual content ratings creep evident violent films explicit violence rated films increased films would previously rated increasingly assigned pattern evident sex rated films exhibited higher levels explicit sex compared preratings period conclusions relatively effective screening explicit sex rating system allowed increasingly violent content films thereby increasing youth access harmful content assignment films current rating system sensitive link violent media exposure youth violence society adolescent health medicine rights reserved
context aware data tailoring studies means system furnish users moment set data relevant current context data may traditional databases sensor readings environmental information close people points interest etc implement context awareness use formal representation conceptual context model used design context schema intensionally represents contexts user may involved considered application scenario following line thought paper develop formal approach corresponding strategy manage evolution context schema given context aware application context perspectives initially envisaged system designer applicable unexpected contexts activated accordingly context schema evolves also evolution corresponding context aware data portions must taken care aim paper thus provide necessary conceptual formal notions manage evolution context schema perspective data tailoring introducing set operators manage evolution proving soundness completeness analyze impact context evolution context based data tailoring process study sequences operator applications optimized finally present prototype validating feasibility approach elsevier ltd rights reserved
contraception cervical cancer screening human papillomavirus hpv vaccination sexually transmitted infection sti screening menstrual disorders issues need addressed reproductive aged women including history solid organ transplantation specific considerations may alter routine care population due teratogenic immunosuppressive medications highly effective contraception important planning appropriately timing pregnancy estrogen containing methods pill patch ring may contraindicated immunosuppression also consideration screening treating stis including precancerous conditions cervix chapter provide framework address specific gynecologic needs women history solid organ transplantation elsevier ltd rights reserved
conventional methods verify gears based manual measurement instruments vernier caliper gauges gear pitch micrometers profilometers among others use instruments widely described technical literature actual industrial arena coordinate measurement machines cmm commonly used obtain appropriate software parameters including tooth profile commercial software measuring gears cmm usually based continuous touch teeth flanks educational centres still common find single point probing point point touch machines transform continuous touch machines new software accessories required costs excessive instructional purposes paper presents geometrical mathematical principles develop software application measuring gears describes implementation using general purpose spreadsheet software purpose conventionally used software cmm supported spreadsheet calculates probe positions direction measurement communication spreadsheet cmm software established ascii files end process spreadsheet displays measurement results thanks graphical computing power making possible improve learning process students training professionals elsevier ltd rights reserved
conventional microcontroller mcu based devices provide fixed services executing statically compiled software chip flash memory paper newly designed demand remote code execution layer microcontroller bus architecture proposed enables seamless execution accessed instructions dynamically loaded cloud side runtime proposed concept applied commercial mcus based arm cortex implemented using cmos process input nand gates overhead experimental results show proposed approach results reduction total chip area eliminating chip flash memory still requiring reasonable code access latency
conventional planar transistor shows shrinking substrate bias effect scaled technology hand epitaxial delta doped channel edc transistor shows substantial amount substrate bias effect even channel length paper unveils physics behind substrate bias effect channel edc transistor technology computer aided design simulation analytical justifications depletion width edc transistor weakly depends upon applied substrate bias scaling channel length depletion width insignificantly gets widened substrate control channel high significant amount substrate depletion charge terminates gate instead source drain degradation threshold voltage roll drain induced barrier lowering coefficient increase substrate bias less edc transistor compared conventional halo free transistor dependence substrate bias sensitivity thickness low doped epitaxial layer concentration high doped layer explored effects reverse substrate bias leakage power dissipation intrinsic delay edc conventional transistors discussed
conventional therapies inflammatory bowel diseases ibd involve combinations pharmacologic agents aminosalicylates azathioprine corticosteroids recently therapeutic scenario heavily increased introduction agents including monoclonal antibodies targeted specific proinflammatory cytokines adhesion molecules induction anti inflammatory cytokines cell activation however use drugs accompanied certain number side effects quite severe rising concerns safety profile furthermore cost emerging therapeutic strategies significant considering increasing incidence chronic trend ibd nutraceuticals broad term used describe product derived food sources claiming extra health benefits beyond intrinsic nutritional value found foods beneficial effects nutraceutical compounds human health emerging last decades although clinical trials performed ibd patients nutraceuticals herbal products vitamins generally accepted safer alternative supplementation conventional therapy vitro ibd animal models studies shown involvement several biological processes including antioxidant defenses cell proliferation gene expression could account role maintenance mucosal barrier integrity control inflammatory pathways modulation immune response data suggest wide spectrum positive effects exerted nutraceuticals high potential therapeutic use humans present review beneficial effects investigated nutraceutical compounds setting human ibd discussed
conventional time series forecast models hardly develop inherent rules complex non linear dynamic systems strict assumptions need always met reality whereas fuzzy time series fts techniques used even records times series uncertainty instability since need strict assumptions previous study fts process aggregating past observations assigning proper weights fuzzy logical relationship groups ignored may lead poor forecasting accuracy since important aspects time series prediction analysis determination future trends depends past observations paper novel high order fts model constructed make time series forecasting specifically applying harmony search intelligence algorithm optimal lengths intervals tuned moreover regularly increasing monotonic quantifiers employed fuzzy sets obtain weights ordered weighted aggregation simultaneously weights right hand side fuzzy logical relationship groups explored compensate presence bias prediction part empirical analysis developed model applied predict three well known time series numbers enrollment alabama university taiex electricity load demand new south wales results obtained compared several counterparts including old recently developed models experimental results demonstrate developed model achieve higher accuracy prediction also capture fuzzy features characters elsevier rights reserved
conversion coal dedicated hydrocarbons developed beginning last century still practiced areas world scarcity insecure oil gas supply given need carbon chemistry possible political disruptions oil gas producing regions rise renewable energy lignite secure domestic raw material serve chemical feed stock furthermore serve energy storage using polygeneration ratio power hydrocarbon products follow fluctuating grid requirements north rhine westphalia nrw committee inquiry regarding future chemical industry advocates idea final report released april line position rwe generation rweg pursuing alternative use lignite besides generation electricity expediting related technology development decades far economical reasons prevented option realized commercial scale germany last years together partners science well industry partly government funded rweg develops innovative plant concepts technologies coal product concepts especially challenges chances taken consideration resulting given circumstances changing market situation shifting political goals meet challenge high investment costs rweg pursues called annex approach improve economic viability alternative use lignite annex means use synergies infrastructure established power plant chemical sites planning ctl ctg plant addition process steps critically questioned gas treatment plant whether amine scrubbing applied less costly alternative commonly used rectisol scrubbing reduce footprint use renewable energy hydrocarbon products next way integrating electrolytically produced process another way substitute carbon consumption needed gasification temperatures electrical heating elsevier ltd rights reserved
converting geographic features place names map images vector format first step incorporating cartographic information geographic information system gis advancement computational power algorithm design map processing systems considerably improved last decade however fundamental map processing techniques color image segmentation map layer separation object recognition sensitive minor variations graphical properties input image scanning resolution result map processing results would meet user expectations user properly scan map interest preprocess map image using compression train processing system accordingly issues could slow advancement map processing techniques unsuccessful attempts create discouraged user community less sophisticated tools would perceived viable solutions thus important understand kinds maps suitable automatic map processing types results process related errors expected paper shed light questions using typical map processing task text recognition discuss number map instances vary suitability automatic processing also present extensive experiment diverse set scanned historical maps provide measures baseline performance standard text recognition tool varying map conditions graphical quality text representations vary even within map sheet experimental results help user understand expect fully semi automatic map processing system used process scanned map certain varying graphical properties complexities map content elsevier ltd rights reserved
cooking oils integral part human diet used almost types culinary practices serve sources lipids significant nutritive value health benefits attributed fatty acid compositions biological antioxidants however cooking oils usually subjected thermal oxidation occurs fresh cooking oil heated high temperatures various food preparations repeated use cooking oils commercial food industry also common maximize profit thermal oxidation edible oils since attracted great attention nutritionist researchers given deteriorative effect generation cytotoxic compounds loss carotenoid phenolics vitamins thus reducing overall antioxidant properties oils furthermore several vivo studies suggested consumption thermally oxidized cooking oils might healthy might negatively influence lipid profile increased low density lipoprotein ldl decreased high density lipoprotein hdl elevated cholesterol level haematological system alteration concentration heamoglobin packed cell volume pcv white blood cell wbc count neutrophil lymphocyte counts kidney function induce lipid peroxidation oxidative stress associated pathogenesis various degenerative diseases therefore thermal oxidation seems provide health benefit deteriorates cooking oils consumption oils may predispose consumers various disease conditions may ensue free radical generation thereby deleterious effect human health
coping strategies exert important influence development course substance use disorder sud major depressive disorder mdd treatment outcomes examined coping strategics related treatment sud sud mdd patients associations clinical characteristics forty sud sud mdd males group composed therapeutic community ambulatory treatment patients assessed coping strategies inventory clinical characteristics questionnaires sud mdd patients scored higher disengagement strategies social withdrawal lower engagement ones problem solving cognitive restructuring social support well self perceived capacity coping differences treatment found sud specially sud mdd patients scored higher norms maladaptive strategies time abstinence age onset severity sud related maladaptive coping sud sud mdd patients prone employ disengagement coping strategies sud mdd patients coping repertory maladaptive sud ones likewise clinical characteristics associated maladaptive coping might differ diagnosis modality treatment male patients findings could considered treatment design improve recovery prevent relapses
copper produced large scales high specific activities late using compact cyclotrons based reaction many radiopharmaceuticals developed since various groups based interesting physicochemical nuclear properties radionuclide unique emission beta particles well positron particles offers spectacular real therapeutic diagnostic theranostic radionuclide nuclear medicine although development copper radiopharmaceuticals continued slower rate due availability tracers however recent advances application therapeutic doses emerged new trend radiopharmaceutical development based coppe review recent advances copper theranostic radiopharmaceuticals including introduction new chelating groups enhanced stability well radiolabelling conditions well application simple cucl radiopharmaceutical areal theranostic agent human subjects summarized proposed strategy development peptide based copper radiopharmaceuticals high low dose therapeutic applications suggested
coral reefs maintain extraordinary biodiversity provide protection tsunamis storm surge inshore coral reef health degrading many regions due deteriorating water quality deconvolving natural anthropogenic changes water quality hampered lack long term dated water quality data records required forward modelling reef health aid management reef corals provide excellent archive high resolution geochemical trace element proxies span hundreds years potentially provide records used holocene hence geochemical proxies corals hold great promise understanding changes ancient water quality inform broader oceanographic climatic changes given region article reviews highlights use coral based trace metal archives including metal transported rivers ocean incorporation trace metals coral skeletons current state art utilizing coral trace meatl proxies tools monitoring various types local regional source specific pollution river discharge land use changes dredging dumping mining oil spills antifouling paints atmospheric sources sewage three commonly used coral trace element proxies closely associated river runoff great barrier reef considerable uncertainty remains regarding complex biogeochemical cycling controlling mechanisms however coral based water quality reconstructions suffered lack understanding called vital effects early marine diagenesis main challenge identify eliminate influence extraneous local factors order allow accurate water quality reconstructions develop alternate proxies monitor water pollution rare earth elements great potential self referencing reflect basic terrestrial input elsevier rights reserved
coral reefs provide important ecological services biodiversity climate regulation cultural benefits recreation tourism however many world reefs declining caribbean reefs suffering significant decline living corals past half century situation emphasizes need assess monitor reef conditions using variety methods study new method assessing reef conditions inform management using participatory mapping coral reef experts virgin islands usvi described occupational scuba divers recruited map coral reef conditions uses threats stressors using internet based mapping website data reveal uneven geographic distribution reef conditions usvi frequently mapped perceived healthy reef characteristics large amount physical reef structure markers endangered threatened species present large amount live coral cover greatest perceived threats invasive species water pollution unsustainable fishing areas important reef characteristics perceived threats reefs perceived recovery potential plotted identify areas requiring critical management attention authors found perceptions healthy reef conditions outnumbered perceptions reef threats nine ten familiar coral reefs frequent activity type within coral reefs tourism diving familiar coral reefs divers perceived high recovery potential given novelty participatory mapping methods assess coral reefs strengths weaknesses method evaluated authors propose management typology categorizing reef areas inform future management absence primary data supplement underwater surveys remotely sensed data reef condition participatory mapping provide cost effective means assessing coral reef conditions identifying place specific reef locations requiring management attention
cordyceps bassiana one cordyceps species anti oxidative anti cancer anti inflammatory anti diabetic anti obesity anti angiogenic anti nociceptive activities mushroom recently demonstrated ability reduce dinitrofluorobenzene induced atopic dermatitis symptoms nga mice study examined phytochemical properties mushroom column chromatography hplc analysis chromatographic separation spectroscopic analysis compounds dimethylguanine adenosine uridine nicotinamide methyluracil dimethylxanthine nudifloric acid mannitol identified different fractions subfractions evaluation anti inflammatory activities using reporter gene assay mrna analysis compound found block luciferase activity induced kappa suppress mrna levels cyclooxygenase cox tumor necrosis factor tnf alpha therefore data strongly suggests compound acts one major principles cordyceps bassiana anti inflammatory anti atopic dermatitis activities
cornelia lange syndrome cdls due mutations genes structural regulatory proteins make cohesin complex considered cohesinopathy disorder recently transcriptomopathy new phenotypes recognized expanding field multiple clinical issues facing individuals forms cdls particularly neurodevelopmental system also gastrointestinal cardiac musculoskeletal aspects developmental cell biology found common endpoints biology cohesin complex improved understanding mechanisms easier diagnostic tests possibility potential therapeutics major clinical implications individual cdls following abstracts presentations cornelia lange syndrome scientific educational symposium june orlando conjunction cornelia lange syndrome foundation national meeting addition scientific clinical discussions talks related practical aspects behavior including autism transitions communication access medical care databases end symposium panel held included several parents affected individuals genetic counselors discussed greatest challenges life information assist guiding future research research committee cdls foundation organizes meeting reviews accepts abstracts subsequently disseminates information families members clinical advisory board publications ama cme credits provided greater baltimore medical center baltimore
correlations early late efficacy endpoints assessed identify potential surrogate endpoints overall survival progression free survival pfs clinical trial level data three non hodgkin lymphoma nhl subtypes diffuse large cell lymphoma dlbcl follicular lymphoma mantle cell lymphoma mcl one hundred eight phase iii trials trial arms dlbcl mcl identified included database correlations efficacy endpoints analyzed using weighted linear regression pearson coefficient determination newly diagnosed dlbcl month pfs strongly correlated year confidence interval six month pfs strongly correlated year pfs moderately correlated year mcl trials linear regression determined increase month pfs would yield increase year dlbcl increase year pfs increase year mcl month pfs complete response rate moderately correlated median pfs trials respectively six month pfs potential surrogate endpoint year newly diagnosed dlbcl mcl year pfs month pfs rate potential surrogate endpoints median pfs patients confirmation validation correlations may facilitate early interpretation nhl trials
corrosion high strength steel wires suspension bridge main cable attributed environment within cable wrapping sensor network developed monitor provide information order indirectly assess environmental conditions deterioration interior suspension bridge main cables overall functionality individual sensors monitoring system tested full scale mock cable cable mock covered aluminum wrapping environmental chamber built around order subject test specimen sensor network aggressive corrosive environment created cyclic temperature humidity conditions temperature relative humidity corrosion rate levels recorded sensors recorded data analyzed attempt determine general trends correlations environmental variables effects corrosion rates recorded temperature fluctuations highly dependent sensor depth within cable however levels cyclic testing near linear temperature increases decreases recorded close cable center baseline corrosion rate levels affected levels significant increases corrosion rates levels greater temperature changes proved impact corrosion rates cyclic level high correlations temperature corrosion rate readings recorded linear polarization resistance corrosion rate sensors
corrosion steel bars concrete major problem reducing concrete structure lifetime must considered design structures many parameters involved corrosion propagation contain different uncertainties therefore probabilistic analysis performed paper proposed reliability analysis method frames subjected simultaneous corrosion static loads consists analysis arbitrary frame time step take account steel bars mass loss due corrosion calculated instantaneous load bearing capacity elements analysis outputs would extracted probability failure reliability index could calculated time step moreover conducted sensitivity analysis parameters shown various parameters cover thickness dimensions strength materials reinforcements could improve vulnerability concrete structure subjected corrosion obtained outputs based various corrosion models proposed different researchers obtained results compared one another good agreement experimental results literature proposed method shows corrosion process could decrease strength structural elements significantly
cortical spreading depression plays important role multiple neurological disorders studied primarily experimental models use highly invasive methods developed relatively non invasive optogenetic model induce cortical spreading depression transcranial stimulation channelrhodopsin ion channels expressed cortical layer neurons light evoked cortical spreading depression anesthetized freely behaving mice studied intracortical potentials multi unit activity non invasive laser doppler flowmetry optical intrinsic signal imaging anesthetized mice cortical spreading depression induction thresholds propagation rates similar invasive potential non invasive laser doppler flowmetry recording paradigms cortical spreading depression related vascular parenchymal optical intrinsic signal changes similar evoked kcl freely behaving mice potential multi unit activity recordings combined laser doppler flowmetry revealed cortical spreading depression characteristics comparable anesthesia except shorter cortical spreading depression duration cortical spreading depression resulted short increase followed prolonged reduction spontaneous active behavior motor function assessed wire grip tests transiently unilaterally suppressed following cortical spreading depression optogenetic cortical spreading depression induction significant advantages current models multiple cortical spreading depression events elicited non invasive cell type selective fashion
cortical surface area tremendously expanded human evolution similar patterns cortical expansion observed childhood development intriguing hypothesis high expanding cortical regions also show strongest correlations intellectual function humans however know regional distribution correlations intellectual function cortical area maps onto expansion development evolution sample participants show regions cortical area correlates visuospatial reasoning abilities generally high expanding development evolution several regions frontal cortex especially anterior cingulate showed high expansion development evolution area regions related intellectual functions humans low expanding areas related cognitive scores findings suggest cortical regions involved higher intellectual functions expanded development evolution radial unit hypothesis provides common framework interpretation findings context evolution prenatal development additional cellular mechanisms synaptogenesis gliogenesis dendritic arborization intracortical myelination likely impact area expansion later childhood
cosmetic development exclusively guided notions rational effectiveness also notions sensoriality thus sensorial properties cosmetic product studied using internationally recognized discriminating descriptive methods descriptive sensory profiling essential tool process allows experienced panel assess qualitative quantitative characteristics product results obtained method enable get accurate image product however given new demands industrial world new innovation paths shorter development times complex products willingness include consumers process need access new methods arisen alternative methods offer product positioning ratings attribute citation frequency implemented either panel experts consumers flash profile pivot profile check apply cata methods cosmetic professionals started test article reviews methods used sensory assessment cosmetic products analysis carried shows complementarity application sensory assessment essential upstream innovation phase product
covert channels communication channels transmit information utilizing existing system resources without detected network security elements firewalls thus utilized leak confidential governmental military corporate information malicious users like terrorists use covert channels exchange information without detected cyber intelligence services therefore covert channels grave security concern important detect eliminate disrupt covert communications active network wardens attempt eliminate channels traffic modification implementation also hamper innocuous traffic always acceptable owing large number covert channel algorithms possible deal case case basis therefore necessitates unified system model represent paper present event based model represent timing covert channels based model calculate capacity various covert channels evaluate essential features impact network jitter noise packet losses also used simulations obtain parameters verify accuracy applicability
criminal psychopathy defined emotional detachment psychopathy checklist revised pcl factor antisocial behaviour pcl factor previous work associated antisocial behaviour psychopathy abnormalities ventral temporo amygdala orbitofrontal network however little known neural correlates emotional detachment imaging studies indicated default mode network dmn particular dorsomedial medial prefrontal posterior cingulate component contributes affective social processing healthy individuals furthermore recent work suggests network may implicated psychopathy however research examined relationship psychopathy emotional detachment white matter underpinning dmn therefore used diffusion tensor imaging dti tractography offenders psychopathy non offenders investigate relationship emotional detachment microstructure white matter connections within dmn included dorsal cingulum containing medial prefrontal posterior cingulate connections dmn ventral cingulum containing posterior cingulate medial temporal connections dmn found fractional anisotropy reduced left dorsal cingulum psychopathy group moreover within group emotional detachment negatively correlated tract portion bilaterally left right results suggest importance dorsal dmn emotional detachment observed individuals psychopathy propose dual network model white matter abnormalities disorder incorporates previous findings elsevier ltd rights reserved
criminologists conspicuously absent debate media violence aggression article author attempts fill void discussing relationship exposure television film violence violent behavior context empirical theoretical literature violent crime criticisms literature media violence offered disjuncture absence media violence criminological literature emphasis disciplines also discussed concluded empirical literature media violence aggression established exposure media violence causes violent criminal behavior
crocodilians nature difficult animals study however research wild animals essential development reliable long term management describe methods acquisition monitoring behavioural physiological variables free ranging crocodilians use archival tags data loggers via satellite radio acoustic telemetry specifically attachment implantation electronic tags described examples provided type data collected research group used combination approaches monitor movements diving activity body temperatures heart rates crocodilians including studies australian freshwater crocodile crocodylus johnstoni estuarine crocodile crocodylus porosus caiman caiman latirostris approach method presents unique challenges problems chiefly consequence differences body morphology size crocodilian species behaviours habitats occupy
crohn disease chronic relapsing inflammatory disease increasing incidence prevalence worldwide previous years accumulation microarray data provided approach obtain insight present study microarray data comprehensively analyzed using multiple bioinformatics methods pathobiological process disease examined gene expression data colon tissues patients obtained gene expression omnibus database following differentially expressed genes identified control sample groups subsequently gene ontology kyoto encyclopedia genes genomes analyses performed investigate functions pathways differentially expressed genes enriched targetscan mirdb databases used predict micrornas mirnas regulated differentially expressed genes result total differentially expressed genes including upregulated downregulated genes including matrix metallopeptidase glutathione transferase alpha identified samples differentially expressed genes significantly involved regulation inflammatory response innate immune response cell migration extracellular matrix organization janus kinase signal transducers activators transcription signaling pathway cytokine cytokine receptor interaction mirna gene network showed mir mir regulated differentially expressed genes findings extend current understanding mechanisms underlying differentially expressed genes regulator mirnas identified may used potential biomarkers therapeutic targets
crop water status important parameter plant growth yield performance greenhouses thus early detection water stress essential efficient crop management dynamic response plants changes environment called speaking plant multisensory platforms remote sensing measurements offer possibility monitor real time crop health status without affecting crop environmental conditions therefore aim work use crop reflectance temperature measurements acquired remotely crop water status assessment two different irrigation treatments imposed tomato plants grown slabs filed perlite namely tomato plants irrigation certain period well watered plants plants grown controlled growth chamber measurements carried august september crop reflectance measurements carried two types sensors multispectral camera measuring radiation reflected three spectral bands centred regions spectroradiometer measuring leaf reflected radiation based measurements several crop indices calculated results showed crop reflectance increased due water deficit detected reflectance increase significant following irrigation withholding results first derivative analysis reflectance data showed spectral regions centred could used crop status monitoring addition results present study point sphotochemical reflectance index modified red simple ratio index modified ratio normalized difference vegetation index could used indicator plant water stress since values correlated well substrate water content crop water stress index last extensively used crop water status assessment greenhouses open field thus could concluded reflectance crop temperature measurements might combined provide alarm signals crop water status reaches critical levels optimal plant growth
cross sectional ovalization thin walled circular steel tube large plastic bending also known brazier effect usually occurs initial stage tube continuous rotary straightening process amount ovalization defined maximal cross section flattening important technical parameter tube straightening process control tube bending deformation prevent buckling however lack special analytical model maximal section flattening determined accordance specified charts developed experienced operators basis experimental data thus inevitable localized buckling might occur actual straightening operations new normal strain component formulas derived based thin shell theory strain energy thin walled tube per unit length obtained using elastic plastic theory rational model predicting maximal section flattening thin walled circular steel tube straightening process presented principle minimum potential energy new model validated experiments numerical simulations results show new model agrees well experiments numerical simulations error less new model expected find potential application thin walled steel tube straightening machine design
cryptography via public key cryptosystems pkc widely used providing services confidentiality authentication integrity non repudiation security computational efficiency another major issue concern pkc largely controlled either modular exponentiation scalar multiplication operations found rsa elliptic curve cryptosystem ecc respectively one approach address operational problem via concept addition chain exhaustive single operation involving large integer reduced sequence operations consisting simple multiplications additions existing techniques manipulate representation integer binary ary prior performing series operations paper proposes iterative variant sliding window method swm form ary family shorter sequence multiplications corresponding modular exponentiation thus called iterative swm moreover specific ecc imposes extra resource point negation paper proposes iterative recoded swm operating integers recoded using modified non adjacent form naf speeding scalar multiplication relative behaviour also examined number additions scalar multiplications integers hamming weight proposed iterative swm methods reduce number operations standard swm heuristic result even shorter chains operations ones returned many metaheuristic algorithms
cuznsns czts narrow band gap semiconductor used couple tio enhancing utilization solar energy article tio thiol reduce grapheme oxide trgo czts heterostructure constructed via facile situ solvothermal method situ solvothermal method could acquire uniform particles sizes aggregation czts adjusting sulfur source reactant solvent formation mechanism tio trgo czts structure combination behavior trgo czts proposed thiol groups trgo give site czts grow form chemical bond could stabilize connection czts trgo situ reaction czts composite electrode exhibited better photoelectrochemical performance self assemble czts elsevier rights reserved
cubic splines euclidean space minimize mean squared acceleration among curves interpolating given set data points extend observation riemannian manifold discrete shells associated metric measures bending membrane distortion generalization replaces acceleration covariant derivative velocity introduce effective time discretization novel paradigm navigating shell space transferring concept space triangular surface descriptorsedge lengths dihedral angles triangle areasresults simplified interpolation method high computational efficiency
cue reactivity important concept relapse substance use disorders sud although cue exposure therapy discussed relapse prevention current approaches still need improvement considering efficacy neurobiological perspective related activation sensitized subcortical structures projections motivationally relevant cortical structures orbitofrontal cortex ofc deficient prefrontal inhibitory control therefore analyzed prefrontal cortical activation relation craving smoking focused ofc projection area sensitized subcortical structures due importance processing reinforcement value dorsolateral prefrontal cortex dlpfc based importance behavioral inhibition functional near infrared spectroscopy fnirs used assess hemodynamics prefrontal regions smoking subjects occasional smokers controls subjective craving intensity minimum craving marker baseline inhibition range marker inhibition time course additionally assessed craving ratings indicated elicited solely smokers controls subjective ratings correlated hemodynamic activity ofc craving range dlpfc minimum craving ofc activation found earlier throughout smokers compared controls connectivity seed based correlation ofc dlpfc increased smokers fnirs capture prefrontal hemodynamic activity involved elicited therefore promising method investigate implications relapse prevention sud
culture plays important role arab middle east society unique historical social religious traditions require special attention cultural traits exercise authority control interaction however little research investigated effects national culture management practices construction companies research investigates relationship questionnaire survey interviews sample construction companies united arab emirates uae solicits views type experiences concerning effect key national cultural dimensions adopted management practices research demonstrates construction companies within uae construction industry developed adopted unique management style mixture western eastern management applications companies primarily adopted clan culture emphasizes development human resources flexibility decentralization teamwork consensus decision making information sharing
cultures honor turkey prioritize defending individual family reputations gender specific ways nisbett cohen men maintain honor via reputations toughness aggression control women avenging insults women maintain honor obedience men sexual modesty religious piety honor beliefs support women subordination justifying violence sev yurdakul violence women therefore challenged understanding honor beliefs ideological correlates may inform efforts hypothesized benevolent sexism subjectively favorable system justifying ideology would strongly positively predict turkish women versus men honor beliefs whereas hostile sexism openly antagonistic toward women would strongly positively predict turkish men versus women honor beliefs additionally due justifications gender inequality embedded islamic religious teachings expected islamic religiosity positively predict honor beliefs genders convenience sample turkish undergraduates women men ankara completed ambivalent sexism inventory religious orientation scale honor endorsement index regression analyses revealed benevolent hostile sexism positively predicted women honor beliefs whereas hostile benevolent sexism positively predicted men honor beliefs islamic religiosity positively predicted honor beliefs genders unexpectedly strongly men women suggest combating benevolent sexism promoting feminist interpretations islamic religiosity may help empower turkish women challenge honor beliefs
current approaches visual inertial odometry vio able attain highly accurate state estimation via nonlinear optimization however real time optimization quickly becomes infeasible trajectory grows time problem emphasized fact inertial measurements come high rate hence leading fast growth number variables optimization paper address issue preintegrating inertial measurements selected keyframes single relative motion constraints first contribution preintegration theory properly addresses manifold structure rotation group formally discuss generative measurement model well nature rotation noise derive expression maximum posteriori state estimator theoretical development enables computation necessary jacobians optimization posteriori bias correction analytic form second contribution show preintegrated inertial measurement unit model seamlessly integrated visual inertial pipeline unifying framework factor graphs enables application incremental smoothing algorithms use structureless model visual measurements avoids optimizing points accelerating computation perform extensive evaluation monocular vio pipeline real simulated datasets results confirm modeling effort leads accurate state estimation real time outperforming state art approaches
current atherosclerosis treatment strategies primarily focus limiting cholesteryl esters accumulation reducing endogenous synthesis cholesterol liver therapy currently available enhance removal crucial step reduce burden existing disease given central role hepatic cholesteryl ester hydrolase ceh intrahepatic hydrolysis subsequent removal resulting free cholesterol work applied galactosefunctionalized polyamidoamine pamam dendrimer generation gal hepatocyte specific delivery ceh expression vector data presented herein show increased specific uptake gal ceh expression vector complexes simply gal ceh hepatocytes vitro vivo furthermore upregulated ceh expression hepatocytes significantly enhanced intracellular hydrolysis high density lipoprotein associated hdl subsequent conversion secretion hydrolyzed bile acids increased ceh expression liver significantly increased flux hdl biliary well fecal meanwhile gal induce hepatic renal toxicity also immunotoxic encouraging pre clinical testing results using safe highly efficient hepatocyte specific gene delivery platform enhance hepatic processes involved cholesterol elimination promising strategy alleviation atherosclerosis elsevier ltd rights reserved
current concepts growth hydraulics higher plants critically revisited concluded partly fail interpret experimental data adequately particularly case hydroponics grown roots theoretical considerations indicate growth rate roots controlled extensibility cell wall excluding water availability hydraulic conductance major constraint supported findings growth rate scale turgor radial axial water potential gradients observed root elongation zone nevertheless water potential deficit ranging mpa repeatedly reported growing cells far exceeds shallow trans membrane water potential difference required uptake growth water unexpectedly growth also shown depend hydraulic conductance plasma membrane root cells even though generally large impact growth leaves similar observations reported interpretation data less straightforward inconsistencies associated current model growth hydraulics prompt author suggest revised model comprises addition passive mechanism water transport across plasma membrane growing cells mediated aquaporins leak secondary active water transport pump analogy mechanism previously demonstrated mammalian epithelia postulated xylem parenchyma cells roots water hypothesised secreted trans membrane water potential difference cotransport solutes salts sugars amino acids taking advantage free energy released transport step solute concentration gradient supposed maintained subsequent retrieval solutes apoplast back transport expense metabolic energy water secretion tends reduce turgor pressure retards growth turgor turn growth upregulated rapidly independent adjustment osmolyte deposition rate increasing reducing secondary active water transport root exposed mild osmotic stress confirmed experimental studies
current differencing transconductance amplifier cdta receiving considerable attention building block current mode analog signal processing signal generation paper new cdta based lossless grounded floating inductance simulation circuits proposed proposed grounded simulated inductance circuit employs two cdtas single grounded capacitor whereas floating simulated inductance circuit employs three cdtas grounded capacitor circuit grounded inductance require realization conditions whereas case floating inductance equality two transconductances needed easily maintained practice ensuring equal bias currents two transconductance amplifiers sample results demonstrating applications new simulated inductors using cmos cdtas given confirm workability new circuits
current image processing techniques capture large vessels reliably often fail preserve connectivity bifurcations small vessels imaging artifacts noise create gaps discontinuity intensity hinders segmentation vascular trees however topological analysis vascular trees require proper connectivity without gaps loops dangling segments proper tree connectivity also important high quality rendering surface meshes scientific visualisation printing present fully automated vessel enhancement pipeline automated parameter settings vessel enhancement tree like structures customary imaging sources including rotational angiography magnetic resonance angiography magnetic resonance venography computed tomography angiography output filter pipeline vessel enhanced image ideal generating anatomical consistent network representations cerebral angioarchitecture topological statistical analysis filter pipeline cornbined computational modeling potentially improve computer aided diagnosis cerebrovascular diseases delivering biometrics anatomy vasculature may serve first step fully automatic epidemiological analysis large clinical datasets automatic analysis would enable rigorous statistical comparison biometrics subject specific vascular trees robust accurate image segmentation using validated filter pipeline would also eliminate operator dependency observed manual segmentation moreover manual segmentation time prohibitive given vascular trees thousands segments bifurcations interactive segmentation consumes excessive human resources subject specific trees first step toward patient specific hemodynamic simulations assessing treatment outcomes
current product lifecycle management systems plm concentrated product design manufacturing engineering development material flows layouts paper proposes approach describe represent main required manufacturing process data using ontologies together generic data standards approach makes possible develop translations different software also providing users meaning different concepts contributes efficient management manufacturing information focus material flow information used discrete event simulation des
current research suggests incidence heterogeneity autism spectrum disorder asd symptoms may arise variety exogenous endogenous factors subject routine clinical practice generally considered safe exists speculation though human data diagnostic ultrasound may also contribute asd severity supported experimental evidence exposure ultrasound early gestation could perturb brain development alter behavior explored modified triple hit hypothesis williams casanova assay possible relationship severity asd symptoms ultrasound exposure first trimester pregnancy fetuses genetic predisposition asd using retrospective analysis data ssc simon simplex collection autism genetic repository funded simons foundation autism research initiative found male children asd copy number variations cnvs exposure first trimester ultrasound significantly decreased non verbal increased repetitive behaviors relative male children asd cnvs ultrasound data suggest heterogeneity asd symptoms may result least part exposure diagnostic ultrasound early prenatal development children specific genetic vulnerabilities results also add weight going concerns expressed fda non medical use diagnostic ultrasound pregnancy autism res international society autism research wiley periodicals inc
current treatment pediatric inflammatory bowel disease ibd patients often ineffective serious side effects manipulating gut microbiota via fecal microbiota transplantation fmt emerging treatment approach remains controversial aimed assess composition fecal microbiome comparison pediatric ibd patients healthy siblings evaluating risks prospects fmt setting case control sibling study conducted analyzing fecal samples six children crohn disease six children ulcerative colitis healthy siblings metagenomic sequencing addition lifetime antibiotic intake retrospectively determined species richness diversity significantly reduced patients compared control mann whitney test false discovery rate mwu fdr bacteria positively influencing gut homeostasis eubacterium rectale faecalibacterium prausnitzii significantly reduced abundance mwu fdr known pathobionts like escherichia coli enriched patients mwu fdr moreover coli abundance correlated positively several virulence genes scc fdr shift toward antibiotic resistant taxa ibd groups distinguished controls mwu benjamini hochberg yekutieli procedure fdr mwu fdr collected results confirm microbial dysbiosis pediatric lesser extent patients replicating associations found previously using different methods taken together observations suggest microbiotal remodeling therapy family donors least children viable option
currently power gas technologies considered viable solutions face onset problems associated renewable capacity firming indeed carbon free hydrogen production converting renewable electricity excess injection natural gas pipelines considered short medium term solution way called blends fired within internal combustion engines micro gas turbines operating chp mode offering better environmental energy performances machines regards distributed energy generation scenario local production means electrolysis methane enrichment cost effective oxygen fruitfully used instead venting like product usually occurs study focuses usefulness using oxygen enrich air fuel mixture internal combustion engine micro chp applications fuelled hng blends thus main aim paper provide set values benchmarking blends ranging vol burn within ice partial oxy fuel conditions particular preliminary energy analysis carried based experimental data reporting engine operating parameters gains losses electrical heat recovery efficiency oxygen content air varies vol volkswagen blue tender chp commercial version rated electrical power output considered reference machine energy characterization reported operated unconventional conditions authors published elsevier ltd
currently centers disease control prevention recommends persons years get tested human immunodeficiency virus hiv least lifetime persons hiv risk factors get tested frequently limited research examining factors associated never testing hiv among non hispanic black men united states purpose study examine prevalence never testing hiv reasons never testing hiv correlates never testing hiv analyzed national survey family growth data restricted analyses male respondents aged years self identified non hispanic black logistic regression models estimated adjusted prevalence ratios apr assessing association socio demographic behavioral factors never testing hiv estimated non hispanic black males aged years never tested hiv non hispanic black men aged years apr years apr visit doctor healthcare provider apr report sexual risk behaviors past months apr likely never test hiv compared respective counterparts continued expansion hiv testing initiatives prevention programs focus non hispanic black men critical addressing hiv related health disparities public health burden hiv population
currently two basic types intrauterine devices iuds copper hormonal however types iuds development clinical trials around world continued development focused increasing efficacy longer duration use noncontraceptive benefits review discusses currently available intrauterine contraceptives cua iud levonorgestrel releasing intrauterine systems novel intrauterine contraceptives available select parts world including intrauterine ball low dose copper products frameless devices intrauterine delivery systems impregnated noncontraceptive medication novel products currently development
customisation increasingly becoming necessity areas life one special field interest area medical products example textile orthotics enable customer specific individualised optimum curing current personalisation processes within development production processes textile orthotics barely address full range customer diversity efficient development production customer specific textile orthotics established many process steps currently characterised manual labour increasing public private expense need efficient development production customer specific diversity aware orthotics realised virtualised processes paper describes basic characteristics virtual development production framework individualisation textile orthotics respect diversity customers characteristics computer aided design cad approaches adapt dimensions individualised orthotics virtually asses fit discussed detail digital functionalisation flexible module production individualised orthotics introduced paper reduction time consumption improvement process flexibility process performance cad approaches digital funtionalisation qualitatively specified
customizing desired naturalistic fluid simulation result video obtain similar artistic effect significant practice art directed customizing challengeable due chaotic nature physics contained still remains difficult task spite rapid advancements computer graphics last two decades paper focuses problem physically based fluid simulation foundational customize desired naturalistic simulation result video example previous achievements conventional algorithms primarily recover geometry fluid surface obtain velocity fluid particles video however launch new derivative results geometry velocity enough physically based driven models promising present novel method capable efficiently recovering physically driven model existing video advocate new approach calculate velocity non normalized surface geometry constraints appearance dynamic behavior example fluid multi scale framework use calculated physical properties quickly recover fluid driven model particular calculate surface geometry accurately introduce scale factor normalized geometry non normalized geometry acquire accurate result propose novel recovery algorithm particle densities lattice boltzmann method recovered accurately matching fluid advection geometry calculated non normalized geometry fluid simulations different types density achieved including constrained particle density auto advection density enhanced particle density demonstrate results several challenging scenarios provide qualitative evaluation method applications based approach also demonstrated implementation
cutting plane algorithm cpa generalization iterative first order gradient method objective function approximated successively supporting hyperplanes cpa tailored solve regularized loss minimization machine learning exploiting regularization structure particular linear support vector machine svm embedding line search procedure effectively remedies fluctuations function value speeds convergence practical issue however existing line search strategy based sorting algorithm takes mlogm time paper propose effective line search solver spends linear time extended multiclass svm optimized explicit piecewise linear function finding algorithm prearranged total svm training time proved reduce theoretically experiments consistently confirm effectiveness proposed algorithms elsevier ltd rights reserved
cytochrome cyp enzymes heme containing monooxygenases catalyze metabolisms various endogenous exogenous compounds constitute superfamily enzymes present various organisms including mammals plants bacteria insects cyps diverse metabolize wide variety substrates structures largely conserved study bioinformatic analyses cyp enzymes performed seed plants organisms protein sequences including species different families according conserved motifs obtained meme mast tools four motifs common seed plants structural functional analyses six selected species seed plants organisms investigated protparam sopma predotar signalp tmhmm tools expasy database tertiary structures arabidopsis thaliana sample seed plants five samples organisms predicted phyre server using model pdb accession code protein sequences aligned clustalw algorithm megalign dnastar lasergene mega phylogenetic tree constructed using neighbor joining method protein protein interactions analysis string tool six enriched pathways identified arabidopsis thaliana species according results high similarity among cyp proteins different species seed plants organisms derived common ancestor obtained data provide background bioinformatic studies function evolution proteins seed plants
dagger modeling visualization framework addresses challenge representing knowledge information decision makers enabling better comprehend operational context network security data allows users answer critical questions given care mission reason worried going cyberspace system fails still able accomplish mission
dairy foods long considered nutrient dense health promoting products offer many health benefits consumers review overview health benefits associated drawing recent research conducted associations dairy food components bone cardiometabolic cognitive digestive health cross sectional intervention studies section details associations dairy certain aspect health focuses benefits milk product consumption may prevention management chronic health conditions osteoporosis metabolic syndrome dementia dairy food components well potential biological mechanisms responsible effects health also addressed although several biological mechanisms warrant research current evidence suggests dairy consumption confers beneficial effects bone cardiometabolic cognitive digestive health due nutrient profile current evidence benefits least daily serving dairy item recommended dietary guidelines several countries yet even united states many individuals consume recommended cups dairy foods day therefore review concludes description current public health impact dairy food research well recommendations food industry formulate dairy foods palatable health promoting consumers
damaged building detection high spatial resolution remote sensing image helps rapid disaster losses assessment however majority traditional methods relies single category feature damaged building letter presents new strategy detecting damaged buildings postquake remote sensing image multiple feature analysis integrity building edge interior roof considered intactness building edge assessed proposing new feature parameter edge significance using significance test quantify difference gradient values edge edge buffer addition gradient orientation inside building analyzed local gradient orientation entropy loe parameter adopted determine whether interior roof damaged general damaged buildings lower values broken edges higher loe values owing debris final decision made basis feature parameters quickbird image yushu china used experiment among total buildings detected correctly overall accuracy better traditional methods
data clustering popular analysis tool data statistics many fields pattern recognition data mining machine learning image analysis bioinformatics aim data clustering represent large datasets fewer number prototypes clusters brings simplicity modeling data thus plays central role process knowledge discovery data mining paper novel data clustering algorithm based modified gravitational search algorithm proposed called bird flock gravitational search algorithm bfgsa bfgsa introduces new mechanism gsa add diversity mechanism inspired collective response behavior birds mechanism performs diversity enhancement three main steps including initialization identification nearest neighbors orientation change initialization generate candidate populations second steps orientation change updates position objects based nearest neighbors due collective response mechanism bfgsa explores wider range search space thus escapes suboptimal solutions performance proposed algorithm evaluated real benchmark datasets well known uci machine learning repository performance compared standard gsa artificial bee colony abc particle swarm optimization pso firefly algorithm means four clustering algorithms literature simulation results indicate bfgsa effectively used data clustering
data become important individuals organizations companies therefore safeguarding sensitive data relational databases become critical issue however despite traditional security mechanisms attacks directed databases still occur thus intrusion detection system ids specifically database provide protection possible malicious users necessary paper present random forests method weighted voting task anomaly detection graph based technique suitable modeling sql queries weighted voting enhances capabilities balancing voting impact tree experiments show weighted voting exhibits superior performance consistency well better error rates increasing number trees compared conventional moreover outperforms state art data mining algorithms terms false positive rate false negative rate
data models central piece information systems relational data models popular extensively used big data due characteristics nosql databases data modeling task seen another perspective databases considered schema free nevertheless databases also need data models ensure proper storage querying data considering vast amount relational databases ever increasing volume data importance data models big data increases work specific set rules proposed automatic transition traditional big data environment considering two specific objectives identification columnar data model hbase supporting operational needs identification tabular data model hive supporting analytical needs obtained results show applicability proposed rules relevance data modeling big data environments
data models knowledge models often use engineering difference technical field short presentation knowledge models offers pre defined solutions delivering knowledge process interested data models put accepted format piece reality purpose paper underline difference two notions sharpen notion knowledge components explicit implicit tacit knowledge approach consists review science literature also presented notion surface knowledge examples work placed context manufacturing engineering technology field
data olfactory bulb development human fetuses stages week birth provided immunohistochemical markers presynaptic terminals anti snap synapsin synaptophysin used evaluate maturation differentiation layers begins periphery indirectly confirms growth olfactory nerve fibers induces anatomical differentiation also differentiation functional layers sites developing glomeruli revealed using immunohistochemical procedure prior stage distinct glomeruli identified using common histological procedure conductive system demonstrates immunoreactivity antibodies presynaptic proteins stages starting weeks fetal development four stages development described functional layers mature week stage differentiation neuroblasts including lamina formation internal granular layer glomerular layer development growth continue week stage weeks fetal development patterns immunoreactivity antibodies snap synapsin synaptophysin weeks prenatal development fully consistent adult complete maturity human reached week prenatal development
data structure important compulsory course computer science engineering topics course require detailed view various algorithms queues stacks sort search trees graphs due complexity teaching understanding course focusing measuring student performance course learning outcomes paper describes methodology providing quantitative measurement data structure course methodology uses combination three approaches average threshold performance vector assess course learning outcomes method utilizes data obtained students marks exams tests projects formal assessments computerized system developed based method expedite analysis process
data structures algorithms important foundation topics computer science education however considered hard teach learn usually model complicated concepts refer abstract mathematical notions describe complex dynamic changes data structures many students programming courses difficulties master required competencies skills especially introductory level literature different ways enhance learning programming deal important dropout rate recently games increasingly used education various fields hypothesize games potential important teaching tool interactive engaging immersive activities improve student engagement motivation consequently learning end developing game teach basic algorithmic concepts algorithms aim initially investigate educational games developed used computer programming domain review level address aforementioned difficulties propose role playing game called algogame based existing solutions incorporates new elements pre validation game novice students encouraging demonstrates learning programming enhanced playing algogame
database systems play important role computer science software mobile applications store populate data server site relational databases dominate professional market requires students familiar structured query language sql client server standard architecture database industry therefore students strongly motivated hands sql assignments projects using tier architecture database courses best learning experience student tables environment data interfere data students however difficult teachers manage individual privileges every student tables sql programs students accessing common shared database paper proposes mechanism students use create database account grant proper privileges minimizes instructor workload eliminating need manage students accounts tables teaching databases proposal also provides interface allows students perform exercises allows instructor review share students real time answers class methods minimize workload grading sql assignments teaching databases providing students opportunity practice lab assignments students also verify whether sql statements working using review module instructor results show assignments simple sql statements grading efficiency increased least allows instructor increase amount assignments result increased practice students grades improved
database table lots records record ranked ranking process problems like ranked selection condition record ranked first using find highest possible among tables record implement maximizing problem relation used find application promotion characterization baseline approach applied greedy method gives high accurate result compared exhaustive enumeration work going propose naive method fining ranking priority based give efficient fining rank contributions include linear time algorithm determining optimal selection range ordinal attribute techniques choosing prioritizing promising selection predicates apply addition require single predicate attribute dis junction predicates include table inferior attributes predicates input size predicate selection module whole dataset large compared attributes domain size
david triggle career educator researcher essayist ethicist many ways paralleled post wwii emergence biomedical research ecosystem originated concept endless frontier ensuing years biomedical research irreparably changed nature society vaccines birth control pill new generations drugs biologics treat infections sexually transmitted diseases psychiatric disorders cardiovascular diseases led shift population demographic elderly chronically sick leading major issues provision effective affordable healthcare much world population present article addition providing brief biography appreciation david triggle contributions science authors expand three topics major interest improving quality reproducibility relevance basic biomedical research declining career opportunities graduates era decreased funding end endless frontier dynamic provision universal healthcare dysfunctional wasteful politicized systems current medical industrial complex delivering healthcare elsevier inc rights reserved
dbmask system implements encrypted query processing support complex queries fine grained access control create update delete cryptographically enforced read crud operations data stored untrusted database server hosted public cloud past research efforts adequately addressed flexible access control encrypted data different granularity levels critical data sharing among different users applications dbmask proposes novel technique separates fine grained access control encrypted query processing evaluating sql queries encrypted data enforces fine grained access control granularity level column row cell based expressive attribute based group key encryption scheme dbmask require modifications database engine thus maximizes reuse existing dbms infrastructures experiments evaluate performance encrypted database managed dbmask using queries tpc benchmark comparison plain text postgres evaluate functionality prototype using policy simulator multi user web application results show dbmask efficient scalable large datasets
deap dielectric electro active polymer new type smart material actuator based deap material tends applied variety occasions prosperous future employed automotive field paper focused design implementation low input voltage high output voltage bidirectional converter driving deap actuator detailed design implemented parameters summarized especially high voltage transformer experiments performed validate design implementation
decades research emphasized role coercive ineffective discipline plays shaping child adolescent conduct problems yet emerging body evidence suggested parents emotion socialization behaviors esbs reactions emotions discussion emotions emotion coaching may also implicated meta analysis examined concurrent longitudinal associations parental esbs conduct problems tested moderators associations systematic search identified studies data concurrent associations esbs conduct problems available studies reporting prospective associations parental esbs found significantly associated concurrent prospective conduct problems order small effect sizes key findings moderator analyses esbs strongly associated conduct problems younger ages esbs focused socialization negative rather positive emotions findings support integration esbs family based models antisocial behavior potential inform design parent training interventions prevention treatment child conduct problems
decentralization improve service delivery also generate externalities across jurisdictional boundaries examine nature size water pollution externalities rivers flow across jurisdictions panel data water pollution brazilian rivers coupled county splits change locations borders allow identify spatial patterns pollution rivers approach cross borders controlling fixed effects trends specific location theory externalities predicts pollution increase increasing rate river approaches downstream exit border structural break slope pollution function border larger number managing jurisdictions exacerbate pollution externalities find support four predictions data satellite data growth night time lights along rivers show local authorities allow settlements develop close rivers downstream portions counties likely underlying mechanism border effects pollution pronounced cost inter jurisdictional coordination lower
decision support systems enhance health monitoring iot scenarios early detection neurodevelopmental disorders children thus ambient intelligence could support innovative application domains like motor cognitive impairments detection home environment paper describes design innovative cooperative system galatea supports refinement process knowledge base expressed owl ontology ontology supports decision making process core web based smart system aimed enhance screening language disorders medical centers schools fostering identification developmental disorders years old age set child smart care services use ambient intelligent paradigm early attention motor impairments children often diagnosed treated health care entities
declining costs solar photovoltaics excitement new technologies led speculation self sufficient battery storage systems soon become competitive traditional electricity service compare grid tied residential solar system grid solar plus battery system locations calculate three effects grid defection private net costs homeowner change system generation costs change system emissions average location grid solar system almost double price grid connected solar associated higher system generation costs emissions benefit elsevier ltd rights reserved
deep convolutional neural networks demonstrated breakthrough accuracies image classification series feature extractors learned cnn used computer vision tasks however cnn features different layers aim encode different level information high layer features care semantic information less detail information low layer features contain detail information suffer problem background clutter semantic ambiguity propose exploit complementary strengths different layers simple effective way mapping function designed highlight effectiveness low layer similarity measuring fine grained similarity query linage nearest neighbors similar semantic extensive experiments show method achieve competitive performance popular retrieval benchmarks extensive experiments show proposed method outperforms features extracted single layers direct concatenations meanwhile method achieves competitive performance popular retrieval benchmarks
deep learning popular feature learning method used variety computer vision applications past years surprisingly technique especially convolutional neural networks convnets structure exploited identify human actions achieving great success algorithms existence directly adopt basic convnets structure works pretty well ideal situation stable lighting conditions however performance degrades significantly intra variation relation image appearance occurs within category solve problem propose new method integrating semantically meaningful attributes deep learning hierarchical structure basically idea add simple yet effective attributes category level convnets attribute information able drive learning procedure experimental results based three popular action recognition databases show embedding auxiliary multiple attributes deep learning framework improves classification accuracy significantly
deep well dnw maps developed two different flavors approach specifications vertex detectors dissimilar experimental environments super factory ilc first generation maps pixel data sparsification time stamping capabilities available tested beam first time september devices fabricated commercial cmos process triple well structure available ultra deep submicron technology exploited using deep well charge collecting electrode high integration density technology complex digital functions included pixel implementing sparsified readout architecture pixel matrix time stamping paper reviews features ilc class superb class maps devices discussing different design terms pixel pitch analog signal processing digital readout architecture superb data driven continuously operating readout scheme adopted along macropixel matrix arrangement whereas ilc matrix read long inter train period versions address hit pixels transmitted chip along time stamp experimental performance chips provides assessment deep well maps potential view future applications paper also discusses way forward development devices outlining issues tackled design full size deep well maps actual experiments sensors could take advantage technological advances microelectronic industry vertical integration impact new technologies design performance dnw pixel sensors could large potential benefit various device features charge collection properties digital readout architecture
deep transcranial magnetic stimulation dtms relatively new technique uses different coils treatment different neuropathologies coils made soft copper windings multiple planes lie adjacent skull located within special helmet magnetic fields combine improve depth penetration dtms coil designed stimulate bilateral prefrontal cortices greater effective stimulation left right positioning left side coil close left dorsolateral prefrontal cortex dlpfc coil used multisite study leading fda approval treatment resistant depression position coil also explored possible treatment negative symptoms schizophrenia bipolar depression migraine moved different positions subject skull coil also explored possible treatment conditions manipulation coil demonstrated ptsd alcohol dependence positioning medial prefrontal cortex mpfc anxiety positioning right prefrontal cortex rpfc auditory hallucinations tinnitus positioning temporoparietal junction tpj parkinson fatigue multiple sclerosis positioning motor cortex pfc corresponding electrical field diagrams measured oscilloscope saline filled head included
defect detection classification ceramic tile surface defects occurred firing units usually performed human observations factories paper automatic image processing system high accuracy time efficient approaches presented end first defect detection rotation invariant measure local variance rimlv operator statistical methods employed defect edges detection cooperatively close morphological operator structural methods used fill smooth detected regions detected defects one ceramic tile labeled corresponding geometric features extracted finally multi class support vector machine classifier winner takes strategy based statistical pattern recognition theories employed identify defect type
deficits behavioral cognitive regulation prevalent children reared poverty relative affluent children due effects adverse conditions developmental underpinnings skills despite evidence suggest emergent processes susceptible environmental inputs research documenting short term intervention program influences regulatory domains young impoverished children limited sought determine proximal effects universal school based intervention paths curriculum social emotional relational cognitive outcomes urban poor kindergarten children four schools high poverty neighborhoods similar demographic characteristics randomly assigned either paths attentional control teacher reported measures behavior attention concentration aggression peer nominations likability aggression acceptance tasks gauging inhibitory control administered fall kindergarten spring one academic year months paths children received paths exhibited significantly greater improvements control students across teacher rated behavioral measures social competence emotion regulation prosocial behavior peer relations behavioral problems aggression internalizing behaviors impulsivity hyperactivity post test well improvements motor inhibition line research constitutes important frontier prevention research given implications improving ultimate outcomes otherwise disadvantaged children
deficits social interaction hallmarks neurological psychiatric disorders however underlying mechanism still unclear show loss dendritic cell factor dcf nervous system mice induces social interaction deficiency autism like behaviour influences social interaction via dopamine system dopamine receptor agonist rescues social cognition phenotype improves short term plasticity together study presents new genetic mechanism affects social interaction may provide new way improve positive social interaction treat autism spectrum disorders elsevier rights reserved
defining unified modelling language uml profiles allows adaptation uml metamodel specific domain area platform etc context awareness one particular domains need well adapted use uml language model specific situations users applications therefore necessary create specific modelling notations particular domain paper present extension uml notations profile used context aware applications development ubiquitous computing environment proposed uml context aware profile package specific profiles extend standard notations three uml diagrams chosen according different views system use case diagram sequence diagram activity diagram diagram propose uml extension mechanisms stereotypes constraints tagged values model contextual situation adequate graphic representation element context use able represented uml profile demonstrate feasibility work example medical field shown using staruml software modelling platform work complete list extended notations class diagram presented previous work order propose complete uml profile
degradation extracellular matrix type collagen col induced proinflammatory cytokines tumor necrosis factor alpha tnf alpha important hallmark osteoarthritis oxytocin well known neurohypophysical hormone synthesized paraventricular pvn supra optic nuclei son hypothalamus study found oxytocin receptor otr expressed human primary chondrocytes expression reduced chondrocytes patients response tnf alpha treatment dose dependent manner notably shown tnf alpha induced degradation col restored treatment dose dependent manner addition tnf alpha treatment highly elevated expression mmp mmp chondrocytes reversed dose dependent manner gene protein expression levels addition demonstrated jak stat pathway involved restoration effects degradation col lastly knockdown otr abolished inhibitory effects degradation col induction mmp mmp expression suggesting involvement otr study implied therapeutic potential cartilage degradation elsevier inc rights reserved
deliberate practice important many areas learning including learning program computers however beliefs nature personal traits known mindsets profound impact practice previous research shown fixed mindset believe traits change tend reduce level practice encounter difficulty contrast growth mindset believe traits flexible tend maintain regular practice despite level difficulty however focusing mindset single construct focused intelligence may appropriate field computer programming exploring notion self belief survey distributed undergraduate software engineering students revealed beliefs intelligence programming aptitude formed two distinct constructs furthermore mindset programming aptitude greater utility predicting software development practice follow survey showed became fixed throughout instruction thus educators consider role programming specific beliefs design evaluation introductory courses software engineering particular need situate contextualize growth messages motivate students experience early setbacks
demand management residential buildings key component toward sustainability efficiency urban environments recent advancements sensor based technologies hold promise novel energy consumption models better characterize underlying patterns paper propose probabilistic data driven predictive model consumption forecasting residential buildings model based bayesian network framework able discover dependency relations contributing variables thus relax assumptions often made traditional forecasting models moreover able efficiently capture uncertainties input variables quantify effect system output test proposed approach data provided pacific northwest national lab pnnl collected pilot smart grid project examine performance model multiscale setting considering various temporal min hourly intervals spatial households region household resolutions analyzing data demand forecasting individual households levels first step toward designing personalized targeted policies customer widely studied topic digital marketing researches done energy sector results indicate bayesian networks efficiently used probabilistic energy modeling residential buildings discovering dependencies variables elsevier ltd rights reserved
demonstrating non inferiority clinical trials usually challenging showing superiority multiple sclerosis non inferiority trials rarely designed since would require prohibitive sample sizes brief report reasons non inferiority trials usually larger superiority trials explored
deployment large scale grid connected photovoltaics power plants requires reliable technical evaluation reduce electricity demand achieve efficient utilization electricity generated lower penetration levels likely energy mix could supply utility demand thus requiring extra units generators higher penetration levels may oversupply demands thus wasting generator capacity thus determining optimum installed capacity technical limits economic benefits large scale systems main issues power utilities decision makers study describes development validation alternative method called generation demand matching model gdmm evaluating large scale implementation grid connected power plants peninsular malaysia relative interface traditional power grid system method explicitly provides detailed assessment temporal spatial factors facilitate match generated electricity electricity demand evaluation factors analyzed using simulations performance located optimal sites optimal sites along physical constraints mapped using geographic information systems gis visualization representation location electricity generation different levels penetration predicted hourly year using time series analysis allowed comparison electricity generation electricity demand evaluate impacts increasing levels penetration novel feature proposed method combination topographical topological map data metric data ability new method accurately predict performance compared pvwatts demonstrates robustness method evaluating technical limits systems conventional power systems elsevier ltd rights reserved
deposition dust solar collectors potential costly part utility scale solar energy production operation maintenance large facilities frequently located arid regions dusty soils orientation solar fields respect wind may affect vulnerable protected soil surface erosive power wind field measurements wind flow utility scale solar photovoltaic facility presented multiple measurements wind speed spinning cup anemometer wind direction rotating vane collected consecutive rows panels two heights ground dataset provides preliminary insight mean flow field nominally two dimensional solar array better understanding non steady flow components turbulence conditions initiation sand transport needed accurate prediction dust impacts facilities
depressed mood complex relationship self evaluation personal competence multiple populations absence depression may associated overestimation abilities mild depression seems lead accurate self assessment significant depression may lead underestimation functioning study expand previous work directly comparing association different levels depression everyday functioning cognitive functional capacity performance self assessment everyday functioning large sample outpatients schizophrenia participants low self reported depression overestimated everyday functioning compared informant reports higher levels depression associated accurate self assessment subgroup patients underestimated functioning depressive symptom severity associated poorer informant rated social functioning differences vocational functioning everyday activities cognitive performance functional capacity associated severity self reported depression minimal evidence impact depression aspects everyday functioning objective test performance substantial relationship depression accuracy self assessment
depression hypertension frequently present together clinical practice evaluating interaction depression hypertension would help stakeholders better understand value depression prevention primary care retrospective study aimed evaluate excessive burden depression overall health health care utilization expenditure among hypertensive patients total hypertensive patients icd identified medical expenditure panel survey meps data patients depression icd hypertension depression associated worse health status physical component score reduction mental component score reduction higher utilization health care services outpatient visits higher nights hospitalization higher medication prescription higher higher health care expenditures inpatient higher prescription drugs higher
depressive delusion key symptom psychotic depression also known major depressive disorder psychotic features icd delusional topics limited guilt impoverishment hypochondria kurt schneider described three primordial fears human beings psychotic depression distinguished particular severity frequency episodes illness well increased suicidal tendencies although one five patients major depression experiences psychotic symptoms condition easily overlooked appropriate therapy initiated use case histories illustrate obstacles diagnosis arising difficulty identifying delusions hidden person experience depression life history personality targeted active exploration difficulties significant taking account observable symptoms subjectively experienced symptoms phenomenological approach chosen explore matter depressive delusion investigate interaction delusion affect special importance anxiety genesis delusion accordance current treatment recommendations background proposed pharmacological strategy supplemented use benzodiazepines often past
depressive symptomatology ibd patients known predict disease activity turn increase depressive symptoms perpetuating cycle depression ibd symptomatology mechanisms contribute relationship disease activity depressive symptoms clearly investigated yet since emotion regulation considered particularly relevant define impact adverse experiences different outcomes current study aimed examine longitudinal influence two maladaptive emotion regulation processes cognitive fusion brooding association disease activity depressed mood study conducted month period using sample ibd patients completed self report validated measures three different waves correlation analyses cross lagged panel models performed main result study discovered experience ibd symptomatology baseline although positively linked manifestation depressed mood months later directly predict depressive symptoms relationship rather indirect explained engagement cognitive fusion brooding maladaptive emotion regulation processes revealed consistent time link ibd symptoms subsequent depressed mood findings indicate clinicians aware emotion regulation processes patients tend use handle difficult experiences inclusion psychological assessments interventions healthcare ibd patients seriously considered implications discussed
design development advanced materials electromagnetic applications bringing materials use one challenging tasks materials engineering silicon based polymer derived ceramics pdcs natural candidates demanding applications due attractive microstructure properties compared sintered technical ceramics sic sin alo zro polymer derived ceramics offer possibility flexible plastic technical processing instance means injection molding extrusion without employment additional binder systems chemical synthesis permits purposeful optimization polymers respect workability ceramic yield composition substitution different elements basic structure well organic side groups many cases microstructure pdcs characterized homogeneous distribution semiconducting conducting nano phases amorphous matrix lead good microwave absorbing properties thus materials may satisfy impedance matching also rapidly attenuate electromagnetic waves absorption properties pdcs easily tailored design molecular precursor changes morphology volume fraction filler particles different classes preceramic polymers briefly introduced absorption properties adjustable phase compositions microstructures presented review elsevier ltd rights reserved
design manufacturing dfm especially use manufacturing knowledge support design decisions received attention academic domain however industry practice studied enough provide solutions mature industry current state art dfm often rule based functionality within computer aided design cad systems enforce specific design requirements rule based functionality may may dynamically affect geometry definition rule based functionality exists cad system typically customisation case case basis manufacturing knowledge phrase vast meanings may include knowledge effects material properties decisions machine process capabilities understanding unintended consequences design decisions manufacturing one dfm questions answer manufacturing knowledge depending definition used earlier product life cycle enable collaborative development environment paper discuss results workshop manufacturing knowledge highlights several research questions needing study paper proposes recommendations investigating relationship manufacturing knowledge shape behaviour context characteristics product produce better understanding knowledge important addition proposal includes recommendations investigating system level barriers reusing manufacturing knowledge model based manufacturing may ease burden knowledge sharing lastly proposal addresses direction future research holistic solutions using manufacturing knowledge earlier product life cycle
design effective efficient fractional order pid fond controller generalization standard pid controller based fractional order calculus industrial control system obtain high quality performances great theoretical practical significance perspective multi objective optimization paper presents novel fopid controller design method based improved multi objective extremal optimization moeo algorithm automatic regulator voltage avr system problem designing fond controller avr firstly formulated multi objective optimization problem three objective functions including minimization integral absolute error iae absolute steady state error settling time improved moeo algorithm proposed solve problem adopting individual based iterated optimization mechanism polynomial mutation plm perspective algorithm design proposed moeo algorithm relatively simpler nsga single objective evolutionary algorithms genetic algorithm particle swarm optimization pso chaotic anti swarm cas due fewer adjustable parameters furthermore superiority proposed moeo fopid condoner nsga based fopid single objective evolutionary algorithms based fopid controllers moeo based nsga based pid controllers demonstrated extensive experimental results avr system terms accuracy robustness elsevier rights reserved
design optimal fuzzy scheme fuel cell battery vehicle control power flow main components fuel cell electric motor battery various driving conditions considered paper purpose firstly optimum sizes main components calculated means particle swarm optimization pso algorithm subsequently fuzzy logic controller flc devised control power flow finally flc optimized various driving patterns optimal control scheme based pso application proposed energy management fuel cell vehicle fcv various traffic conditions one mentioned stages optimization process conducted applying genetic algorithm comparison result pso results computer simulation compared diverse driving conditions results give acceptable indication progress fuel economy various driving patterns using proposed optimal fuzzy controller sharif university technology rights reserved
design proportional integral derivative pid controllers based imc principles various types integrating systems time delay proposed pid parameters given terms process model parameters tuning parameter tuning parameter imc filter time constant present work imc filter chosen manner order denominator imc controller one less order numerator imc filter time constant tuned way good compromise made performance robustness servo regulatory problems improve servo response controller set point filter designed closed loop response similar first order plus time delay system proposed controller design method applied various transfer function models non linear model equations jacketed cstr demonstrate applicability effectiveness performance proposed controller compared recently reported methods terms iae itae smooth functioning controller determined terms total variation compared recently reported methods simulation studies carried various integrating systems time delay show effectiveness superiority proposed controllers isa published elsevier ltd rights reserved
designing efficient effective keypoint descriptors image plays vital role many computer vision tasks traditional binary descriptors local binary pattern variants directly perform binarization operation intensity differences local affine covariant regions thus performance usually drops lot limited distinctiveness paper propose novel image keypoint descriptor namely local derivative quantized binary pattern object recognition incorporate spatial information first divide local affine covariant region several subregions according intensity orders sub region quantize intensity differences central pixels neighbors adaptive way order differences use hash function map differences binary codes binary codes histogramed form feature subregion furthermore utilize multi scale support regions pool histograms together represent features image approach need prior codebook training hence flexible easy implemented moreover descriptor preserve local brightness edge information traditional binary descriptors also descriptor robust rotation illumination variations geometric transformations finally conduct extensive experiments three challenging datasets objects zubud kentucky object recognition experimental results show descriptor outperforms existing state art descriptors
designing lightweight security protocols cloud based internet things iot applications battery limited mobile devices smart phones laptops topic recent focus ciphertext policy attribute based encryption abe viable solution particularly cloud deployment encryptor write access policy authorized users decrypt access data however existing abe schemes based costly bilinear maps require long decryption keys ciphertexts incur significant computation costs encryption decryption costs least linear number attributes involved access policy design drawbacks prevent deployment abe schemes battery limited mobile devices paper propose new rsa based abe scheme constant size secret keys ciphertexts cskc time complexity decryption encryption scheme shown secure chosen ciphertext adversary well efficient solution expressive gate access structures comparison related existing schemes thus proposed scheme suitable deployment battery limited mobile devices
desktop toontalk first released twenty years ago successfully used children young construct computer programs uniquely programs constructed demonstration using game elements robots birds trucks boxes magic wands user avatar inhabits town computations created executed animated manner toontalk reborn conceptualization toontalk web runs modern browser without plugins move become web based tool web programming resulted much gained lost
despite advances psychological interventions pediatric chronic pain little research examining mindfulness meditation conditions study presents data pilot clinical trial six week manualized mindfulness meditation intervention offered adolescents aged years measures pain intensity functional disability depression parent worry child pain obtained baseline post treatment results indicated significant changes pain depression however functional disability frequency pain functioning complaints improved small effect sizes parents worry child pain significantly decreased large effect size participants rated intervention components positively teens suggested number sessions increased three case examples illustrate mindfulness meditation effects precautions mindfulness meditation shows promise feasible acceptable intervention youth chronic pain future research optimize intervention components determine treatment efficacy
despite eliminating incidences many diseases united states parents increasingly rejecting vaccines children article examines reasons parents offer argues parents construct dichotomy natural artificial vaccines come seen unnecessary ineffective potentially dangerous using qualitative data interviews observations article shows first parents view children bodies particularly experiences birth infants naturally perfect need protection second parents see vaccines artificial intervention enters body unnaturally injection third parents perceive immunity occurring illness natural superior immunity derived vaccines inferior potentially dangerous finally parents highlight ways natural living serves enhance children immunity rendering vaccines unnecessary taken together dichotomy allows parents justify rejection vaccines form protecting children health findings expose perceptions science technology health meanings body ways inform public health efforts elsevier ltd rights reserved
despite evidence suggesting one earliest indicators eventual autism spectrum disorder diagnoses early motor delay remain interventions targeting motor behavior primary outcome young children autism spectrum disorder aim pilot study measure efficacy intensive motor skill intervention motor skills test gross motor development physical activity accelerometers socialization playground observation peer engagement young children autism spectrum disorder total children autism spectrum disorder aged years participated experimental group participated week intervention consisting motor skill instruction day days week control group receive intervention repeated measures analysis covariance revealed statistically significant differences groups three motor outcomes locomotor partial object control partial gross quotient partial findings shed light importance including motor programming part early intervention services delivered young children autism spectrum disorder
despite virtually universal acceptance gold standard treating bipolar disorder prescription rates lithium decreasing recently although observation multifactorial one obvious potential contributor side effect toxicity burden associated lithium additionally side effect concerns assuredly play role lithium nonadherence paper summarizes knowledge base side effects toxicity suggests optimal management problems thirst excessive urination nausea diarrhea tremor rather common side effects typically annoying even though rather prevalent simple set management strategies involve timing lithium dose minimizing lithium levels within therapeutic range situations prescription side effect antidotes minimize side effect burden patients contrast weight gain cognitive impairment lithium tend distressing patients difficult manage likely associated lithium nonadherence lithium adverse effects kidneys thyroid gland parathyroid glands necessitating monitoring organ functions periodic blood tests cases lithium associated renal effects relatively mild small measurable percentage lithium treated patients show progressive renal impairment infrequently lithium need discontinued progressive renal insufficiency lithium induced hypothyroidism relatively common easily diagnosed treated hyperparathyroidism lithium relatively recently recognized phenomenon
despite post racial rhetoric stereotypes remain salient american youth surveyed elementary middle schoolers northern california conducted case studies students findings showed students hold school related stereotypes get stronger middle school african american latino students experience greater divergence stereotype awareness group endorsement students students eschewed applicability stereotypes demonstrated higher engagement achievement math study implications studying race schools mathematics need urban educators facilitate racialized counter narratives
despite rapid advances cardiovascular research therapeutic strategies ischemic heart disease ihd remains leading cause mortality worldwide micrornas mirnas small noncoding rnas post transcriptionally regulate gene expression past years mirnas emerged key tools understanding pathophysiology ihd potential uses new biomarkers therapeutic targets several studies report regulatory role mirnas regard fundamental components ihd pathogenesis progression lipoprotein metabolism atherogenesis vascular calcification platelet function angiogenesis due high stability biofluids circulating mirnas attracted attention promising biomarkers ihd especially cardiovascular risk prediction diagnosis myocardial infarction furthermore experimental studies demonstrated potential mirna targeted therapy improving hyperlipidemia atherosclerosis angiogenesis review current knowledge role mirnas ihd translational perspectives use discussed
despite similar emotional deficiencies primary psychopathic individuals situated continuum spans controlled disinhibited constructs primary psychopaths found diverge self control cognitive flexibility executive functioning crucially regulated dopamine goal review examine specific alterations mesa cortico limbic system corresponding genes dat comt drd drd might bias development towards controlled disinhibited expression primary psychopathy based empirical data argued primary psychopathy generally related higher tonic population activity striatal neurons lower levels type receptors meso cortico limbic projections may boost motivational drive towards incentive laden goals dampen punishment sensitivity increase future reward expectancy however increasingly higher levels activity striatum moderate versus pathological elevations lower levels functionality prefrontal cortex higher type receptor ratios meso cortico limbic projections may lead increasingly disinhibited impetuous phenotypes primary psychopathy finally order provide coherent view etiological mechanisms discuss interactions serotonin relevant primary psychopathy elsevier ireland ltd rights reserved
despite similarity disinhibited behaviors cognitive affective mechanisms characterize psychopathy externalizing relatively distinct one theoretical perspective suggests psychopathy associated early attention bottleneck precludes processing contextual information leading rigid goal directed focus alternatively externalizing may associated overallocation processing resources motivationally salient information disrupts use cognitive control study male prisoners assessed psychopathic externalizing traits performed new gaze detection task involving affective faces predicted psychopathy externalizing associated superior performance gaze detection task necessity using contextual affect regulate goal directed behavior minimized conversely externalizing psychopathy associated increased errors trials required participants use affective expressions specifically fear cue inhibit dominant responses results theoretical applied significance psychopathic externalizing forms disinhibition recognition utilization facial affect important socialization interpersonal interactions therefore cognitive affective processes interrupt fluency information processed may important understanding underpinnings disinhibition
despite abundance research negative intrusive thoughts far less known positive counterparts two studies explored positive spontaneous thoughts related people favorite activities passions vallerand pers soc psychol doi passions associated thoughts contribute mental health study participants reported valence frequency spontaneous thoughts tend several activities harmonious obsessive passion predicted frequent spontaneous thoughts harmonious passion predicted thought positivity study participants completed measures pertaining physical activity spontaneous thoughts mental health predicted positivity spontaneous thoughts physical activity predicted frequency physical activity positivity spontaneous thoughts physical activity mediated relationship harmonious passion indices mental well
despite existence popularity many new classical computer languages evolutionary algorithm community mostly exploited popular ones avoiding especially compiled asumption compiled languages always faster interpreted languages wide ranging performance analyses implementation evolutionary algorithms usually focused algorithmic implementation details data structures usually limited specific languages paper measure execution speed three common operations genetic algorithms many popular emerging computer languages using different data structures implementation alternatives several objectives create ranking operations compare relative speeds taking account different chromosome sizes data structures dispel show evidence several hypotheses underlie popular evolutionary algorithm libraries applications find indeed basis consider compiled languages java faster general sense languages including interpreted ones hold ground
despite gargantuan market potential printed electronics circuits systems flexible substrate remain nascent number reasons including inavailability process development kits pdks facilitate circuits systems design predict manufacturability due innately high process variations paper describe open platform pdk fully additive low temperature air printing process low process variations pdk embodies novel simple yet accurate transistor model accurately model printed transistors depending layout flat unbent substrate also accurately model process variations bent bent substrate pdk bending important circuits systems whose substrate adhered uneven surfaces bent fit odd spaces thereby expanding applicability circuits systems efficacy open platform proposed transistor model verified means comparisons simulations measurements basic individual printed electronic elements several fundamental printed digital analog circuits comparisons include substrate flat bent depicting bending detrimental may conversely advantageously exploited proposed pdk compatible commercial computer aided design simulation tools
despite importance delegation managerial tool know little leaders characteristics affect decision delegate paper demonstrate holding objective markers power constant psychological sense power predicts preferences delegation specifically individuals feel relatively powerless less willing delegate decision making authority compared feel powerful find support pattern two studies results provide insight factors linking power delegation elsevier ltd rights reserved
despite increasing use portable tablets learning impact received little attention research five different projects media ethnographic design based analysis use portable tablets learning resource science museums investigates young people learning portable tablets matches intentions museums applying media information literacy mil components analytical dimensions pattern discrepancies young people expectations actual learning museums approaches framing learning identified argued paradoxically museums decisions innovate introducing new technologies portable tablets new pedagogies support conflict many young people traditional ideas museums learning assessment implications museums integration portable tablets indicates making pedagogical transformations accommodate new technologies museums risk opposing didactic intention pedagogies sufficiently attend young learners systemic expectations learning expectations digital experience influenced leisure use
despite perceived importance labor market opportunities shaping married women outside option bargaining power within households result link received little empirical attention using longitudinal data makes decision wide range issues within mexican households data administrative records mexican social security institute paper identifies effects relative changes labor market opportunities men women working non working women decision making power find increases labor market opportunities improve women decision making power well children health using differential labor demand shocks across mexican industries caused china admission wto gives similar results elsevier rights reserved
despite proliferation work within construction management draws upon management organizational theory two omissions stand body published work absence real debate values rigour relevance research underuse dominant perspectives business management research institutional theory frame construction management organizational issues drawing specifically upon ideas institutional logics institutional work paper explores tensions ironies contradictions rigour relevance debate challenges opportunities facing construction management research cmr institutions furthering management organizational research agendas attention directed complex contested changing nature knowledge base within business management field well key differences community practice cmr
despite unconditionally secure theory quantum key distribution qkd several attacks successfully implemented commercial qkd systems systems exhibited flaws secret key rate corresponding protocols remains unaltered eavesdropper obtains entire secret key propose negative acknowledgment state quantum key distribution protocol novel protocol capable detecting eavesdropping activity intercept resend faked sates irfs attack without requiring additional optical components different protocol system implemented high software module approach transmitter interleaves pairs quantum states referred parallel orthogonal states receiver uses active basis selection
despite widespread acknowledgement public health organizations media reporting matters suicide link much debated mechanisms undergirding poorly understood study combine media analysis ethnographic data collected examine social dynamics surrounding media reporting suicide community call poplar grove usa enduring adolescent suicide problem illustrate media crafted particular story youth die suicide emphasized academic pressure plausible causes media may broadened ideas suicide seen option however also provide evidence cautions attributing much causal power media media coverage poplar grove reflected conditions already present community already high pressure place youth live widespread mental health stigma factors likely shaped media reporting also contributing independently suicide problem finally found suicide deaths received media coverage triggered significant cognitive dissonance thus much discussed among youth independent media reporting generated ample opportunities peer role modeling suicide thus media may helped solidify certain view suicide community social force contributing suicide poplar grove findings study negate importance responsible reporting suicide contextualize role media suicide suggest researchers must take broader view suicide suggestion operates media social contexts elsevier ltd rights reserved
despite widespread use non vitamin kaeurodependent oral anticoagulants noac recommendations regulatory agencies interdisciplinary expert panels handling bleeding situations noac uncertainty dealing situations still exists especially hospitals low emphasis hemostatics cases mild bleeding clinical perspective medical surveillance patients delay next intake temporary discontinuation recommended cases moderate severe bleeding primary measures focused stabilization cardiopulmonary circulatory functions simultaneously treatment depending localization source bleeding cases life threatening bleeding intracranial hemorrhage special hemostatic management necessary addition hemodynamic stabilization measures predominantly oriented clinical severity
despite via ferrata klettersteig climbing become popular currently appropriate safety equipment available lightweight climbers typical example missing user friendliness children via ferrata carabiner whose dimension compared customary adult equipment unlocking procedure might inadequate child hand new designed effort saving via ferrata carabiner ergotec salewa sportgerate gmbh germany evaluated respect ergonomics user friendliness children adults twelve adults years twelve children adolescents years tested new effort saving via ferrata carabiner ergotec two conventional carabiners one touch edelrid gmbh germany attac salewa sportgerate gmbh germany activities produced flexors brachioradialis flexor carpi ulnaris measured two loading situations using electromyography emg noraxon inc usa new effort saving via ferrata carabiner reduction muscle activity compared two conventional carabiners observed adults well children adolescents however due different hand anthropometry muscle forces differences operation handling via ferrata carabiners position transmission finger forces observed compensate lower finger forces children use advantage better lever arm three tested carabiners distance force transmission hinge joint increased position fingers difficult mount customary carabiners steel cable design via ferrata carabiner ergotec user friendly handling observed also anthropometry smaller child hands authors published elsevier ltd selection peer review responsibility school aerospace mechanical manufacturing engineering rmit university
detecting correlated network flows aids exposing attackers hide behind anonymous networks stepping stones recent flow watermarking schemes link flows often impossible achieve invisibility robustness concurrently letter proposes innovative connection correlation scheme capable remaining invisible attackers idea exploit burstiness chaos inherent network traffic collect unique stable traffic traits used later construct identifier based shamir threshold secret sharing scheme experimental results indicate proposed scheme robust network jitter packet insertions losses
detecting fake accounts online social networks osns protects osn operators users various malicious activities detection mechanisms attempt classify user accounts real benign honest fake malicious sybil analyzing either user level activities graph level structures mechanisms however robust adversarial attacks fake accounts cloak operation patterns resembling real user behavior article show victims real accounts whose users accepted friend requests sent fakes form distinct classification category useful designing robust detection mechanisms particular present integro robust scalable defense system leverages victim classification rank real accounts higher fakes osn operators take actions low ranking fake accounts fntegro starts identifying potential victims user level activities using supervised machine learning annotates graph assigning lower weights edges incident potential victims finally fntegro ranks user accounts based landing probability short random walk starts known real account walk unlikely traverse low weight edges steps land fakes fntegro achieves desired ranking implemented fntegro using widely used open source distributed computing platforms scaled nearly linearly evaluated fntegro sybilrank state art fake account detection using real world datasets large scale deployment tuenti largest osn spain million active users show fntegro significantly outperforms sybilrank user ranking quality requirement employed victim classifier better random moreover deployment fntegro tuenti resulted order magnitude higher precision fake account detection compared sybilrank elsevier ltd rights reserved
detecting sentiment sentences online reviews still challenging task traditional machine learning methods often use bag words representations properly capture complex linguistic phenomena sentiment analysis recently recursive autoencoder rae methods proposed sentence level sentiment analysis use word embedding represent word learn compositional vector representation phrases sentences recursive autoencoders although rae methods outperform state art sentiment prediction approaches commonly used datasets tend generate deep parse trees need large amount labeled data node process learning compositional vector representations furthermore rae methods mainly combine adjacent words sequence greedy strategy make capturing semantic relations distant words difficult solve issues propose semi supervised method combines hownet lexicon train phrase recursive autoencoders call chl prae chl prae constructs phrase recursive autoencoder prae model first model calculates sentiment orientation node hownet lexicon acts sentiment labels train softmax classifier prae furthermore chl prae model conducts bidirectional training capture global information compared rae supervised methods support vector machine svm naive bayesian english chinese datasets experiment results show chl prae provide best performance sentence level sentiment analysis elsevier rights reserved
determination whether magnesium nutrient public health concern hindered questionable dietary recommended intakes dris problematic status indicators make deficiency assessment formidable balance data obtained since indicate ear rda healthy individuals day respectively dris decrease increase based body weight dris less established usa canada urinary excretion data tightly controlled metabolic unit balance studies indicate urinary excretion mmol day intakes mmol day however changing low high urinary excretion increase dietary intake occurs within days vice versa thus urinary stand alone status indicator would useful population studies useful individual status assessment tightly controlled metabolic unit depletion repletion experiments indicate serum concentrations decrease prolonged depletion individual good reserves experiments also found although individuals serum concentrations approaching mmol physiological changes respond supplementation thus metabolic unit findings suggest individuals serum concentrations mmol high mmol could deficit respond supplementation especially dietary intake history showing mmol day urinary excretion mmol day
develop devthis research development module media technology bachelor tries teach third year students scientific research introduce technological design scientific developments area ubiquitous computing internet things iot context sensitivity location based services design use emergent design practices ambient pervasive design ambiperv second year course following practice oriented vision human centered creative technology educating internet things techniques ambiperv students learn work sensors effectors iot applications paper evaluates research versus practice oriented approach educating creative technology internet things compares results terms research opportunities student motivation effort versus outcomes make recommendation teach creative technology internet things
developed green building council leadership energy environmental design leed certifies green buildings different grades according number credit points building achieved leed managers often attempt achieve many credits possible limited budgets resources however referring credit requirements alone help evaluate difficulty achieving credits data leed credits achieved previous projects may offer insights yet research quantitatively analyzed previous records study aims analyze leed credit achievements previous projects using data driven techniques provide leed managers better understanding achievements individual credits related credits projects certified leed collected case base measurement called percentage average score pas proposed analyze individual credits attained past credits like mrc mrc discovered stringent requirements rarely achieved addition relationships among credits analyzed using association rule mining thresholds support confidence identified implementing classification algorithm namely cmar among pairs related credits suggested usgbc pairs identified strongly related addition new pairs related credits suggested usgbc discovered elsevier ltd rights reserved
developers work together software development maintenance resolve issues implement features large software projects structure development collaboration activity may impact quality final product terms higher number defects paper aim understand effect collaboration defect proneness software model collaboration developers undirected network extract centrality developers collaboration network using different measures quantifies importance nodes analyze defect inducing fixing data developers two large software projects findings study summarized follows centrality source code change activity developers collaboration network may change defect induction rates defect proneness change sets contrary common perception experienced people relatively higher defect induction rates elsevier inc rights reserved
developing bead shape process parameter model challenging due multi parameter nonlinear dynamic nature laser cladding environment introduces unique predictive modeling challenges single bead overlapping bead configurations essential develop predictive models boundary conditions overlapping beads different single bead configuration single bead model provides insight respect process characteristics overlapping model relevant process planning travel path generation surface cladding operations complementing modeling challenges development framework methodologies minimize experimental data collection maximizing goodness fit predictive models additional experimentation modeling facilitate important understand key process parameters predictive model methodologies data structures two modeling methods employed develop predictive models analysis variance anova generalized reduced gradient grg approach assist process parameter solutions provide initial value nonlinear model seeding data clustering performed identify characteristic bead shape families research illustrates good predictive models generated using multiple approaches
development new ways provide clean onboard electric energy key feature sailing boat industry sail race teams marine turbines considered provide onboard energy turbines used harness kinetic energy water flow related ship motion paper propose study unconventional design turbine electrical generator located periphery blades magnetic gap water filled kind solution called rim driven structure allows increase compactness robustness system due strong interaction multi physical phenomena electromagnetic model thermal model generator associated hydrodynamic model blades water flow underwater air gap models used global coupled design approach order optimize constraints global efficiency system solution allows optimize system design
diabet med abstract aims studies suggest inadequate sleep duration poor sleep quality increase risk impaired glucose regulation diabetes however associations specific markers glucose homeostasis less well explained objective study explore possible associations sleep duration sleep quality markers glucose homeostasis glucose tolerance status healthy population based study sample methods study comprised participants danish population based cross sectional health study sleep duration sleep quality measured self report markers glucose homeostasis derived point oral glucose tolerance test included fasting plasma glucose plasma glucose hbac two measures insulin sensitivity insulin sensitivity index homeostasis model assessment insulin sensitivity homeostasis model assessment beta cell function glucose tolerance status associations sleep duration sleep quality markers glucose homeostasis tolerance analysed multiple linear logistic regression results increment sleep duration associated mmol mol decrement hbac reduction risk impaired glucose regulation point increment sleep quality associated increase insulin sensitivity index homeostasis model assessment insulin sensitivity well decrease homeostasis model assessment beta cell function conclusions present study shorter sleep duration mainly associated later alterations glucose homeostasis whereas poorer sleep quality mainly associated earlier alterations glucose homeostasis thus adopting healthy sleep habits may benefit glucose metabolism healthy populations
diabetes disrupts operation eye leads vision loss affecting particularly nerve layer capillary vessels layer changes blood vessels retina suddenly loss blurred vision problems occur image depending phase disease called diabetic retinopathy hard exudates one primary signs diabetic retinopathy automatic recognition hard exudates retinal images contribute detection disease present automatic screening system detection hard exudates system consists two main steps firstly features extracted patch images consisting hard exudate normal regions using daisy algorithm based histogram oriented gradients utilized recursive feature elimination rfe method using logistic regression support vector classifier svc estimators raw dataset therefore obtained two datasets containing important features number important features dataset created svc respectively afterward observed different classifier algorithms performances using fold cross validation important features dataset observed random forest classifier best classifier secondly obtained important features feature vector corresponds region interest accordance keypoint information new retinal fundus image performed detection hard exudate regions retinal fundus image using classifier
diabetes increases cardiovascular risk reduces pharmacodynamic response oral antiplatelet drugs study aimed determine whether ticagrelor twice daily bid provided potent consistent platelet inhibition patients without diabetes pegasus timi platelet function substudy patients studied patients randomised received least four weeks ticagrelor bid diabetes patients received ticagrelor bid diabetes patients received placebo diabetes blood sampled pre hours post maintenance dose patients treated ticagrelor bid treatment platelet reactivity adp determined light transmission aggregometry lta verifynow vasp similar patients without diabetes lta post dose adp respectively consistent inhibitory effect ticagrelor bid observed pre post dose regardless diabetes status even insulin treated patients patients diabetes increased incidence high platelet reactivity either ticagrelor group platelet reactivity similar patients diabetes treated ticagrelor bid pharmacokinetics ticagrelor affected diabetes status conclusion ticagrelor bid equally effective reducing platelet reactivity patients without diabetes yielding consistently high level platelet inhibition regardless diabetes status
diabetes chronic systemic disease affecting general population thus constituting important clinical financial problem healthcare systems throughout world complications diabetes damage many internal organs skin skin complications diabetes anticipate clinical symptoms diabetic skin irritated dry many cases susceptible skin infections however little known molecular changes skin diabetes many studies concentrated epidermal barrier damage dysfunction epidermis integrity dysfunction sebaceous glands another complex problem skin care diabetic patients profound understanding cellular level processes diabetes could lead discovery new therapy efficacy markers new skin care products
diabetes mellitus cancer two growing health problems common many modifiable risk factors including sex age obesity physical activity diet alcohol smoking long latency overtly manifesting patients diabetes experience roughly higher cancer incidence compared individuals without diabetes depends cancer site moreover patients diabetes develop cancer increased early late mortality comparison cancer patients without diabetes prediabetes metabolic syndrome also related increased risk developing die cancer possible mechanisms linking diabetes prediabetes cancer include hyperglycemia endogenous exogenous hyperinsulinemia alterations insulin like growth factor system chronic subclinical inflammation abnormalities sex hormone metabolism adipokines becomes crucial define right orientation associations diabetes cancer order identify modifiable pathogenic mechanisms common soil hypothesis claims prediabetes diabetes well metabolic syndrome may considered surrogate sign dietary risk factors cancer clepsydra foods may help choose foods associated healthy benefit avoiding foods associated harm including cancer
diabetic ketoacidosis dka hyperglycemic hyperosmolar state hhs serious life threatening hyperglycemic emergencies diabetes dka common young people type diabetes hhs adult elderly patients type diabetes features disorders ketoacidosis hyperosmolality may coexist characterized insulinopenia severe hyperglycemia early diagnosis management paramount treatment aggressive rehydration insulin therapy electrolyte replacement treatment underlying precipitating events article reviews epidemiology pathogenesis diagnosis management hyperglycemic emergencies
diabetic kidney disease dkd occur approximately type type diabetic patients well established features dkd include increased serum glucose levels along chronic low grade inflammation oxs increased advanced glycation end products sorbitol accumulation increased hexosamine protein kinase pathway activation hand accumulating evidence suggests novel pathways including apoptosis autophagy might also play important roles pathogenesis progression dkd review integrated mechanisms inflammation oxidative stress apoptosis autophagy discussed pathogenesis well progression dkd
diabetic peripheral neuropathy dpn remains one common serious complications diabetes currently pharmacological agents limited treating pain associated dpn address underlying pathological mechanisms driving nerve damage thus leaving significant unmet medical need interestingly research conducted using exercise treatment dpn revealed interleukin signaling associated many positive benefits enhanced blood flow lipid metabolism decreased chronic inflammation peripheral nerve fiber regeneration known solely pro inflammatory cytokine understood signal multifunctional cytokine capable eliciting pro antiinflammatory responses context dependent fashion released muscle response exercise signals myokine unique kinetic profile whereby levels transiently elevated fold return baseline levels within importantly kinetic profile stark contrast long term elevation associated pro inflammatory states given exercise induces myokine signaling exercise shown elicit numerous beneficial effects treatment dpn causal link suggested discuss clinical preclinical literature related application treatment strategy dpn addition discuss may directly modulate schwann nerve cells explore mechanistic understanding treatment elicits neuroprotective regenerative response collectively studies suggest administered low dose pulsatile strategy mimic body natural response exercise may prove effective treatment protection restoration peripheral nerve function dpn review highlights studies supporting assertion provides rationale continued investigation treatment dpn
diacylglycerol kinases dgks catalyze phosphorylation conversion diacylglycerol dag phosphatidic acid dgk isozymes unique primary structures expression patterns subcellular localizations regulatory mechanisms dag preferences dgk hydrophobic segment promotes attachment membranes shows substrate specificity dag arachidonoyl acyl chain position substrate determined role dgk regulation energy glucose homeostasis relation diet induced insulin resistance obesity using dgk epsilon wild type mice lipidomic analysis revealed elevated unsaturated saturated dag species skeletal muscle dgk epsilon mice paradoxically associated increased glucose tolerance although skeletal muscle insulin sensitivity unaltered whole body respiratory exchange ratio reduced abundance mitochondrial markers increased indicating greater reliance fat oxidation intracellular lipid metabolism dgk epsilon mice jlr thus increased intracellular lipids skeletal muscle dgk epsilon mice may undergo rapid turnover increased mitochondrial function lipid oxidation rather storage turn may preserve insulin sensitivity conclusion dgk epsilon plays role glucose energy homeostasis modulating lipid metabolism skeletal muscle
diagnosis specific learning disability dysgraphia impacts children academic progress well dysgraphia diagnosed clinicians based children written product educational staff impressions process time consuming subjective consequently many children mild dysgraphia remain undiagnosed especially lower socioeconomic backgrounds work method automatic identification characterization dysgraphia third grade children described method based analyzing child writing dynamics sampling pressure pen exerts paper well pen position orientation using standard digital writing pad ninety nine samples collected writers dysgraphia proficient writers wide range features covering dynamic properties writing typographic visual properties extracted participant machine learning methodologies used infer statistical model capable discriminating dysgraphic products proficient products approximately accuracy model analyzed conclude handwriting features discriminative since model provides sensitivity specificity first step toward future use effective standard indicator dysgraphia detection
diagnostics drug delivery biomedical industries rely cross linking ligands microbead surfaces microbead functionalization requires multiple steps liquid exchange incubation mixing laborious time intensive although automated systems exist expensive cumbersome limiting routine use biomedical laboratories present small bench top robotic system automates microparticle functionalization streamlines sample preparation robot uses programmable microcontroller regulate liquid exchange incubation mixing functions filters pore diameter smaller minimum bead diameter used prevent bead loss liquid exchange robot uses three liquid reagents processes microbeads per batch effectiveness microbead functionalization compared manual covalent coupling process evaluated via flow cytometry fluorescent imaging mean percentages successfully functionalized beads robot manual methods respectively less bead loss although two methods share similar qualities automated approach required approximately min active labor compared manual approach results suggest low cost automated microbead functionalization system streamline sample preparation minimal operator intervention
diamond foods comprehensive case provides opportunity students apply several financial auditing concepts professional auditing standards real world context diamond overstated earnings fiscal percent percent respectively delaying recognition cost walnuts acquired later accounting periods case requires students determine whether diamond external auditor deloitte touche llp deloitte fulfilled responsibility obtain reasonable assurance financial statements free material misstatement students need determine whether deloitte issuance unqualified opinion diamond financial statements internal controls violated professional auditing standards addition students required evaluate whether deloitte obtained sufficient understanding diamond business industry exercised needed professional skepticism used appropriate analytical procedures discharge professional responsibilities case presents opportunity achieve several learning objectives including development research critical thinking communication problem solving skills case appropriate use graduate undergraduate course financial auditing also used fraud examination course capstone course accounting curriculum
diet speculated factor pathogenesis inflammatory bowel disease may important factor managing disease symptoms patients manipulate diet attempt control symptoms often leading adoption inappropriately restrictive diets places risk nutritional complications health professionals struggle provide evidence based nutrition guidance patients due overall lack uniformity clarity amongst research studies well designed diet studies urgently needed create enhanced understanding role diet plays management inflammatory bowel disease aim review summarize current data available dietary management inflammatory bowel disease demonstrate dietary modulation may important consideration managing disease addressing relevance diet inflammatory bowel disease health professionals able better support patients collaborate dietitians improve nutrition therapy
diet one largest modifiable risk factors chronic kidney disease ckd related death disability ckd largely progressive disease however increasingly appreciated hallmarks chronic kidney disease albuminuria regress time factors driving albuminuria resolution remain elusive since albuminuria strong risk factor gfr loss modifiable lifestyle factors lead improvement albuminuria would likely reduce burden ckd high risk individuals patients diabetes dietary therapy protein sodium restriction historically used management ckd evidence emerging indicate nutrients may influence kidney health either metabolic haemodynamic pathways via modification gut homeostasis review focuses role diet pathogenesis progression ckd discusses latest findings related mechanisms diet induced kidney disease possible optimizing diet quality restricting dietary intake could harnessed adjunct therapy ckd prevention progression susceptible individuals thereby reducing burden ckd
dietary restriction certain fermentable carbohydrates low fermentable oligosaccharides disaccharides monosaccharides polyols fodmap diet effective managing symptoms irritable bowel syndrome ibs however potential consequences diet relate impact nutritional microbiological health related quality life outcomes evidence suggests low fodmap diet leads alterations nutrient intake example carbohydrate intake reduced decrease proportion patients meeting recommended intake calcium intake macro micro nutrients appears adequate short term well impact nutrient intake extensive dietary modification pronounced impact gastrointestinal microbiota indeed recent data suggests diet markedly reduces luminal bifidobacteria concentration limited evidence reduces total bacteria abundance concentration bacterial groups example faecalibacterium prausnitzii finally despite evidence clinical effectiveness patients ibs restrictive nature diet could pose significant burden patients thereby limiting improvements indeed worsening health related quality life conclusion robust evidence supports clinical effectiveness low fodmap diet important considering likelihood continued widespread use ibs functional bowel disorders extend understanding impact diet endpoints may potential consequences long term health
digit ratios contain information concerning individual propensity towards aggression study adds first clue better understanding relationship exposure aggressive contents entertainment products findings suggest individuals low prefer aggressive contents action films sports telecast killing achieving games hip hop music erotic video clips rather individuals high also individuals low tend demonstrate less preference romance films individuals high addition found low associated preference sports instead genres entertainment products therefore putative correlate prenatal sex steroids helps better understand rationale individuals preferences media violence elsevier ltd rights reserved
digital earth global reference model integrating processing visualizing geospatial datasets reference model various data types including digital elevation models dem imagery orthophotos universally openly available entire globe however content detailed terrains features man made structures water bodies vegetation commonly available digital earth paper present interactive system rapid creation integration types content augment digital earth inputs system include available data sources dem imagery information depicting landscapes urban environments proposed system employs sketch based image assisted tools support interactive creation textured content adding terrain features visible orthophotos also basin water bodies use multiscale least square surface fitting generate adaptive triangular subdivision modeling forests vegetation use image based techniques take advantage visible regions colors forests orthophotos man made structures starting single photograph provide simple image assisted sketching tool extract objects correct perspective distortion place desired locations
digital images may contain undesired blurred regions automatic detection regions estimation amount blurriness given image important issues many computer vision applications paper presents simple effective method automatically detect blurred regions proposed method consists two main parts first novel blur metric significantly distinguish blur non blur regions proposed metric used generate blur map encode amount blurriness individual pixels given image finally estimated blur map used segment input image blurred non blurred regions applying pixon based technique proposed approach evaluated focus motion blurred natural images conducting experiments large dataset containing real images defocus blur partial motion blur regions qualitative quantitative measures performed obtained results paper show proposed approach outperforms state art methods blur estimation digital images
digital pulse width modulation dpwm one elementary parts digital control systems control power switch hence become integral part system chips also broadly acknowledged control method power converters principal focus paper design fpga based digital controller buck convertor soc output voltage convertor relies switching control circuit fundamentally fpga digital controller pwm vhdl employed coding digital controller synthesis done using xilinx xst behavioral timing simulation handled modelsim also power analysis using xpower analyzer carried verification code downloaded onto spartan fpga board
digital rights management problem become critical issue due increasing number database applications proposed watermarking methods deal copyright management problem multimedia applied databases directly methods watermark databases use date fields relation work propose method uses time field date attribute watermark relation method uses seconds field hide watermark hour minute field determine date attributes current tuple accommodate watermark information primary key sha used together choose records relation watermarking purposes tuples relations also partitioned make method robust attacks proposed method gives better results various attacks subset deletion alteration modification compared works literature seen results
digital ulcers dus common visible manifestation progressive vascular disease characterizes ssc disease process dus impact significantly patients quality life hand function also biomarker internal organ involvement disease severity aetiology digital vascular disease ssc multifactorial many factors potentially amenable therapeutic intervention management disease ssc multifaceted patient education non pharmacological interventions smoking cessation neglected number drug therapies available prevent phosphodiesterase type inhibitors receptor antagonists treat iloprost dus dus also important two reasons firstly primary end point ssc related clinical trials secondly dus included acr eular ssc classification criteria however reliability rheumatologists grade dus poor moderate best poses challenges clinical practice research purpose review provide reader description spectrum disease ssc including pathophysiology epidemiology clinical burden inform multifaceted approach management
dimensionality reduction challenging task high dimensional data processing machine learning data mining help reduce computation time save storage space improve performance learning algorithms effective dimension reduction technique unsupervised feature selection aims finding subset features retain relevant information paper propose novel unsupervised feature selection method called robust unsupervised feature selection via matrix factorization rufsm robust discriminative feature selection robust clustering performed simultaneously norm local manifold structures data preserved advantages work three fold firstly latent orthogonal cluster centers sparse representation projected data points based matrix factorization predicted selecting robust discriminative features secondly feature selection clustering performed simultaneously guarantee overall optimum thirdly efficient iterative update algorithm based alternating direction method multipliers admm used rufsm optimization compared several state art unsupervised feature selection methods proposed algorithm comes better clustering performance almost datasets experimented elsevier rights reserved
discharge olive mill wastewater omww rivers system crete led heavy organic pollution several drastic environmental impacts current research study aims map evaluate environmental hazards initiated olive mill wastewater pollution discharged surface stream network kolymvari agricultural area located western crete greece implemented methodology based locating source points pollution determining pollutant surface flow paths gis environment hydrological features area delineated gis environment using basically elevation data provided ministry agriculture microscale proved implementation mca quantify environmental risk surface water resources caused omww macroscale risk mapping implemented establishing spatial connection source points pollution possible sedimentation areas furthermore mapping olive mill waste tanks positively improve exercised methodology term assessing potential risks soil groundwater pollution
discovering kinship relations face images wild become interesting important problem multimedia computer vision despite rapid advances face analysis unconstrained environment kinship verification still remains challenging problem subtle kinship relation difficult discover changes pose lighting condition complicate task paper propose kinship verification approach based multi linear coherent space learning local image patches different scales independently projected corresponding coherent spaces learned robust canonical correlation analysis patch pairs kinship relations improved correlation addition discriminative patches verification selected via constrained linear programming experimental results two widely used kinship verification datasets show proposed method effectively identify different kinship relations image pairs compared state art techniques proposed method achieves competitive performance use simple feature descriptors
discrete wavelet transform dwt widely used signal processing applications paper describe hardware implementation lifting based dwt used image compression cdf lifting based wavelet transform modeled simulated using matlab based dsp methodologies signal flow graph dependence graph derived dependence graph optimized used implement hardware description circuit verilog synthesized implemented circuit using field programmable gate array fpga application specific integrated circuit asic design approaches confirm circuit operation post synthesis post layout simulations done fpga asic designs respectively
discretization rasterization introduced method images context deterministic radio propagation modeling way exploit spatial coherence electromagnetic propagation fine grained parallelism traditional algebraic treatment bounding regions surfaces replaced computer graphics rendering reflections double refractions building image tree visibility reception points surfaces also resolved shader programs proposed rasterization shown comparable run time fundamentally parallel shooting bouncing rays rasterization affect signal evaluation backtracking step thus preserving advantage brute force ray tracing methods terms accuracy moreover rendering resolution may scaled back given level scenario detail marginal impact image tree size allows selection scene optimized execution parameters faster execution giving method competitive edge proposed variant run gpu supports real time graphics
discrimination odorous molecules amniotic fluid occur weeks gestation fetuses exhibit differential responses maternal diet olfactory reflexes enable reliable neonatal testing olfactory bulbs demonstrated reliably mri weeks gestation hypoplasia aplasia also documented late prenatal postnatal mri olfactory axons project nasal epithelium telencephalon olfactory bulbs form fetal olfactory maturation remains incomplete term neuronal differentiation synaptogenesis myelination persistence transitory fetal ventricular recess immaturity signify nonfunction olfaction sensory system without thalamic projection intrinsic thalamic equivalent diverse malformations olfactory bulb diagnosed clinical examination imaging neuropathology epileptic auras might primarily generated olfactory bulb cranial nerve tested neonates especially patients brain malformations endocrinopathies chromosomopathies genetic metabolic diseases
discusses design machine building production certain steps formalized problems forecast number parts calculate estimated time simulation application tasks performed approximation fractional power series possibility shown numerical solution models using combined genetic algorithms
disease prevention health care delivery areas traditionally governed nation state local communities increasingly inhabited mobile sovereigns carry global currency prevention strategies treatments grounded universal standards scientific evidence drawing ethnographic evidence research conducted hiv southwest china paper examines impact evidence based science effectiveness global health programming interrogates intentions global health partnerships balance power waged money science technical expertise seeking assistance resources influences global health programming ultimately paper demonstrates disconnect demand system universal standards developed basis scientific evidence appreciation local context shapes way standards modified effective implementation global health programs
disheveled axin domain containing dixdc involved development progression multiple cancers however function significance dixdc prostate cancer remains unclear study investigated function dixdc prostate cancer regulation dixdc micrornas mirnas found dixdc highly expressed prostate cancer cells knockdown dixdc small interfering rnas markedly suppressed proliferation invasion wnt signaling prostate cancer cells dixdc identified target gene mir bioinformatics analysis dual luciferase reporter assay real time quantitative polymerase chain reaction western blot analysis furthermore dixdc expression inversely correlated mir expression prostate cancer tissues overexpression mir significantly inhibited proliferation invasion wnt signaling prostate cancer cells however inhibition mir exhibits opposite effects moreover overexpression dixdc significantly reversed inhibitory effects mir expression taken together results suggest dixdc plays important role regulating prostate cancer cell proliferation invasion targeting dixdc mir may promising therapeutic strategy prostate cancer elsevier inc rights reserved
dislocation behavior critical feature describing reliable properties structures materials new kind smart material multiferroic solids special applications coupling systems mechanical electric magnetic fields moving dislocation multiferroic solids special interests strength characteristics present work moving edge dislocation studied eigenstrain theory explicit solutions derived reduced piezoelectric even pure elastic materials special cases
disorders sex development dsds congenital anomalies affect sexual differentiation genitourinary organs secondary sex characters common cause female genital virilization congenital adrenal hyperplasia cah excess androgen production development females result vaginal atresia masculinization urethra single urogenital sinus clitoral hypertrophy ambiguous external genitalia development vagina depends sexual differentiation urogenital sinus ridge epithelial thickening forms sex ducts attach anterior urethra females sinus ridge descends posteriorly allow vaginal opening form vulva whereas males females cah androgens inhibit descent sinus ridge mechanisms regulate development female urethra vagina largely unknown show timing duration cell population targeted androgen signaling determine position vaginal attachment urethra manipulations androgen signaling utero reveal temporal window development sinus ridge fate determined cell type specific genetic deletions androgen receptor identify subpopulation mesenchymal cells regulate sinus ridge morphogenesis results reveal common mechanism coordinates development vagina feminization urethra may account development single urogenital sinus females exposed excessive androgen critical period prenatal development
dispersed micro nano particle laden gas flows common many engineering environmental applications characterizing dispersed carrier phase using experimental methods important determining properties behavior paper reviews techniques measuring carrier phase well dispersed particles ranging micro nano scale focus developments specific techniques last years also relationships comparisons among techniques addition systematic description classification methods discuss parameters measure particle velocity size composition concentration detailed review provided several important measurement techniques including particle image velocimetry phase doppler particle analyzer light scattering intensity measurements microparticles well scanning mobility particle sizer fast mobility particle sizer electrical low pressure impactor nano particles founding principles development histories various applications techniques going summarized article provides resource investigators plan study micro nano particle laden gas flows various contexts
disruptive behavior disorders dbds inclusive oppositional defiant disorder odd conduct disorder associated outcomes likely increase risk mortality using danish national registers total million individuals including individuals ebds diagnosed specialist services followed first birthday without dbds compared using mortality rate ratios mrrs estimated using poisson regression adjusted calendar period age sex family history psychiatric disorders maternal age time birth paternal age time birth parental education status parental employment status course follow totalled million person years cohort members died including individuals dbds mortality rate per person years individuals dbds compared diagnosis corresponded fully adjusted mrr confidence interval comorbid substance use disorder attention deticit hyperactivity disorder resulted highest mrr across categories findings demonstrate excess mortality associated dbds
distress intolerance inability tolerate stressful experiences linked multiple psychiatric conditions maladaptive coping patterns although often considered trait like variable evidence indicates self report behavioral indices manipulated contextual factors understanding contextual influences important given evidence unexpected variability presumed trait like measures brief intervals current study examined influence context manipulated priming concepts interminability brevity predicting behavioral persistence relation self reported results indicated priming brevity associated terminating cold pressor task quickly self reported linked earlier termination interaction self reported priming condition results indicate contextual cues modulate performance behavioral measures hence models consider trait like contextual factors understanding variability measures
distributed computing good alternative expensive supercomputers plenty frameworks enable programmers harvest remote computing power however today much computation power edges internet remains unused idle devices could contribute distributed environment generic computation resources computation intense applications could use pool resources enhance execution quality paper identify heterogeneity major burden distributed edge computing heterogeneity present multiple forms draw vision comprehensive distributed computing system show existing frameworks fall short dealing heterogeneity distributed computing afterwards present tasklet system approach distributed computing framework tasklets fine grained computation units issued remote local execution tackle different dimensions heterogeneity show make use available computation power edge resources prototype use middleware virtualization technologies well host language concept
distributed denial service ddos austere menace network security time detection ddos attacks poses stiff challenge network security professionals paper authors initiatively propose using novel set information theory metrics called phi entropy phi divergence metrics detecting ddos attacks flash events proposed metrics highly sensitive towards detecting meek variations network traffic elicit information distance legitimate attack traffic flows compared existing predominantly used generalized entropy generalized information divergence gid metrics part work generalized detection algorithm proposed uses entropy difference traffic flows detect different types ddos attacks fes proposed detection algorithm validated using various publically available datasets mit lincoln caida fifa synthetically generated ddostb dataset terms various detection system evaluation parameters elsevier rights reserved
disturbances emotion regulation depressive symptoms common menopause transition reproductive hormone levels directly correlated depressive symptoms factors may influence mood symptoms menopause study sought determine role metabolic function mood symptoms menopause hypothesizing association menopause status long term glucose load studied women across three menopause transition stages premenopause perimenopause postmenopause examining effects age hormones metabolism mood neural activation emotional discrimination assessed participants using behavioral functional mri measures negative emotion emotion discrimination glycated hemoglobin assess long term glucose load found emotionally unpleasant images activated emotion regulation amygdala cognitive association brain regions prefrontal cortex posterior cingulate temporal parietal occipital tpo junction hippotampus cognitive association region activity increased menopause stage perimenopausal women left tpo junction activation postmenopausal women prefrontal cortex posterior cingulate tpo junction activation negative affect associated decreased amygdala activation depression symptoms negative mood associated increased tpo junction activation hemoglobin associated negative interpretation bias neutral images cognitive region recruitment emotion discrimination fsh levels indicating menopause stage associated negative mood age associated behavioral measures activation patterns emotion task results suggest interaction metabolic hormonal factors may influence emotion regulation leading increased risk depression menopause elsevier ltd rights reserved
disturbances microcirculation play significant role development progression acute chronic cerebrovascular diseases cvd one reasons prothrombogenic state endothelium increase number blood corpuscles leading myeloproliferative disorders non mpd headache one prominent clinical symptoms cvd often preceded hematological diagnosis often headache associated focal vascular lesions magnetic resonance imaging acute cerebral events occurring result thrombotic occlusion one several carotid arteries tend exhibit fluctuating clinical course latter closely linked dynamics thrombus progression data suggest decrease vascular wall elasticity athrombogenic properties may lead pathologic change endothelial function consequently leading stroke important clinical feature mentioned cvd young age patients underlines necessity hematological tests cases cryptogenic stroke
diurnal variations ventricular tachyarrhythmias vas demonstrated idiopathic arrhythmogenic heart disease electrophysiological characteristics diurnal variations idiopathic right ventricular outflow tract rvot previously elucidated sixty two consecutive patients undergoing catheter ablation idiopathic rvot mean age years females enrolled diurnal variation type group defined patients ventricular premature contractions vpcs night hours preprocedure holter recordings group defined patients significant vpc variations baseline characteristics electrophysiological properties collected analyzed rates recurrence catheter ablation compared groups study heart rate variability analysis demonstrated lower low frequency high frequency ratios group group significant differences baseline characteristics echocardiography electrophysiological characteristics groups mean follow period months total patients recurrences including patients group patients group study demonstrated effect autonomic nervous system idiopathic rvot vas diurnal variation type leads higher recurrence rate catheter ablation
diverse classes ligands recently discovered relax airway smooth muscle asm despite transient increase intracellular calcium concentrations however cellular mechanisms well understood gelsolin calcium activated actin severing capping protein found many cell types including asm cells gelsolin also binds phosphatidylinositol bisphosphate making substrate less available phospholipase beta mediated hydrolysis inositol triphosphate diacylglycerol hypothesized gelsolin plays critical role asm relaxation mechanistically accounts relaxation ligands transiently increase isolated tracheal rings gelsolin knockout mice showed impaired relaxation beta agonist chloroquine bitter taste receptor agonist relaxes asm despite inducing transiently increased single inhalation methacholine increased lung resistance similar extent wild type gelsolin mice subsequent spontaneous relaxation less gelsolin mice asm cells derived gelsolin mice serotonin induced coupled activation increased inositol triphosphate synthesis greater extent compared cells wild type mice possibly due absence gelsolin binding phosphatidylinositol bisphosphate single cell analysis showed higher filamentous globular actin ratio baseline slower cytoskeletal remodeling dynamics gelsolin cells gelsolin asm cells also showed attenuated decrease cell stiffness chloroquine flufenamic acid findings suggest gelsolin plays critical role asm relaxation activation gelsolin may contribute relaxation induced ligands relax asm despite transient increase
dns domain name system one prevalent protocols modern networks essential correct operation many network activities including malicious operation monitoring dns traffic effective method detect malicious activities paper proposed approach detect malicious domains analyzing massive mobile web traffic data used multiple features classify including textual features traffic statistics features domains presented three typical classifiers compare classifying effect spark framework leveraged speed calculation large scale dns traffic efficiency system makes believe approach help lot field network security
document embedding technology captures informative representations high dimensional observations structure preserving maps corpus intensively explored machine learning recently manifold inspired embedding methods become hot topic mainly due ability capturing discriminative embedding however existing methods capture embeddings based geometrical information nearest neighbors without considering intrinsic documents generating structure subspace thus leads limitation uncover intrinsic semantic information paper propose semi supervised local invariant method called discriminative locally document embedding disc lde aiming build smooth affine map document embedding preserving documents generating structure subspace disc lde models documents generating structure pseudo document generative probabilistic model subspace subspace acquired transductive learning multi agent random walk neighborhood graph regularizes training auto encoders aes jointly recover input document pseudo document general regularized function learning framework regularized training impact parameterized encoder network become smooth variations along documents generating structure local field manifold experimental results three widely used corpora demonstrate disc lde could efficient capture intrinsic semantic structure improve clustering classification performance state arts methods elsevier rights reserved
physical warmth lead caring sharing research suggests physically warm versus cold conditions induce prosocial behaviors cognitions importantly previous research traced developmental origins association physical warmth affection association physical warmth sharing may captured specific cognitive models close social relations often referred attachment styles line notion using dictator game set current study demonstrates children relate friends secure attachment style generous toward peers warm cold conditions effect absent children relate friends insecure attachment style notably however children always shared less allocated stickers friend stranger findings provide important first step understand fundamental embodied relations develop early life discuss broader implications grounded cognition person perception
dopamine immunomodulatory molecule acts immune effector cells cns peripheral tissues however role changes dopamine levels neuroinflammatory response controversial local paracrine renin angiotensin system ras plays major role inflammatory processes peripheral tissues brain present study investigated possible role brain ras effects dopamine glial inflammatory responses astrocytes major source precursor protein angiotensinogen angiotensin aii brain neurotoxins mpp methyl phenylpyridinium act directly astrocytes increase levels angiotensinogen conversely dopamine via type receptors inhibited production angiotensinogen decreased expression angiotensin type receptors increased expression receptors microglia dopamine dopamine agonists also regulated ras activity first indirectly via downregulation astrocyte derived second via dopamine induced regulation microglial angiotensin receptors dopamine decreased microglial ratio leading inhibition pro inflammatory nadph oxidase superoxide axis receptors particularly responsible microglial ras inhibition basal culture conditions however agonists inhibited nadph oxidase axis lipopolysaccharide treated lps activated microglia results indicate decrease dopamine levels observed early stages parkinson disease aging may promote neuroinflammation disease progression via glial ras exacerbation elsevier inc rights reserved
dopamine levels brain influence emotional experiences empathic responses others misfortune inspired roles catechol methyltransferase comt dopamine degradation link moral judgment empathic responses study investigated extent vamet polymorphism comtgene contributes individual differences moral permissibility empathic dispositions one thousand two hundred seventy two chinese han college students differentiated comt vamet polymorphism rated permissibility harm moral dilemmas scored empathic dispositions interpersonal reactivity index results showed significant association comtvamet moral permissibility committing harm individuals val val genotype associated lower levels dopamine endorsed impersonal harm impermissible val met met met genotypes results also showed individuals val val genotype showed higher empathic concern others misfortune findings provide first evidence link comt gene moral permissibility highlighting roles dopamine social cognition elsevier ltd rights reserved
double layer cladding materials fabricated roll bonding using stainless steel sts aluminum sheets investigate thermal conduction multi layer composites measured thermal conductivities compared values calculated cross plane models widely used resistor connections electrical circuits measured thermal conductivity sample containing vol unexpectedly measured cross plane thermal conductivities always higher values calculated series model high cross plane thermal conductivities attributed contribution phonons thermal transfer deviation index thermal conductivity proposed effectively describes cross plane thermal conductivity characteristics double layer materials elsevier ltd rights reserved
double salient electrical machine dsem new type brushless machine advantages simple structure high reliability easy maintenance generator voltage easily controlled excited fault characteristics give dsem unique advantage application non grid connected wind power generator system control theory double salient electrical generator dseg introduced control law system analyzed paper also provides control method realizes maximum power output control parameters increase generator resistance load disturbances load characteristics system examined experiments prototype controlled digital regulator experimental results confirm dseg satisfies resistance load disturbances optimizing control parameters thus meets requirements application wind power generator system
driven dominance relational model requirements modern applications revisit fundamental notion key relational databases null sql primary key columns null unique constraints guarantee uniqueness tuples without null investigate notions possible certain keys keys hold possible worlds originate sql table respectively possible keys coincide unique thus providing semantics syntactic definition sql standard certain keys extend primary keys include null columns uniquely identify entities whenever feasible primary keys may addition basic characterization axiomatization discovery extremal combinatorics problems investigate existence construction armstrong tables describe indexing scheme enforcing certain keys experiments show certain keys nulls occur real world data related computational problems solved efficiently certain keys therefore semantically well founded able meet codd entity integrity rule handling high volumes incomplete data different formats
driving complex task relies manual cognitive visual social skill social demands driving may challenging individuals autism spectrum disorder asd due known social impairments study investigated drivers asd respond social pedestrians non social vehicles hazards driving simulator compared typically developing drivers overall participants responded faster social hazards non social hazards also found drivers typical development reacted faster social hazards drivers asd showed difference reaction time social versus non social hazards future work investigate social impairments asd may affect driving safety
droop control common method universal microgrid applications conventional droop control unpractical low voltage microgrid line impedance among distributed generation units dgs mainly resistive generate active reactive power coupled besides accurate reactive power sharing achieved due voltage deviation dgs caused disparate line impedance microgrid improved droop control based virtual power source vps composite virtual impedance constituted negative resistance negative inductance proposed low voltage microgrid virtual negative resistance counteracts line resistance decouple power reactive power sharing accuracy based virtual negative inductance vpss control increases analysing line virtual voltage drop finally fractional order pid controller adopted control inverter voltage optimal controller parameters obtained differential evolution algorithm verify viability availability improved control strategy simulations carried matlab simulink
droughts typically caused deficiencies precipitation soil moisture affect water resources agriculture soil moisture key importance understanding interaction atmosphere earth surface used monitor droughts study high resolution soil moisture drought index hsmdi proposed evaluated meteorological agricultural hydrological droughts hsmdi developed using downscaled soil moisture data produced advanced microwave scanning radiometer earth observing system amsr march november korean peninsula seven products moderate resolution imaging spectroradiometer modis tropical rainfall measuring mission trmm satellite sensors used downscale amsr soil moisture based random forest machine learning downscaled soil moisture correlated well situ amsr soil moisture mean coefficient determination respectively standardized precipitation index spi time scales months crop yields sesame highland radish highland napa cabbage streamflow data used validate hsmdi various types droughts results showed hsmdi depicted meteorological drought well especially dry season similar pattern month spi however performance fluctuated bit wet season possibly due limited availability optical sensor data heterogeneous land covers around stations hsmdi also showed high correlation crop yield data particular highland radish napa cabbage cultivated non irrigated regions mean however hsmdi monitor streamflow well hydrological drought presenting various range correlations streamflow data elsevier rights reserved
drug drug interactions corticosteroids causing cushing syndrome secondary adrenal suppression well known hiv patients corticosteroids widely prescribed hiv positive population however digoxin rarely used hiv patients hence digoxin toxicity due drug drug interaction widely recognised nevertheless practice might change future hiv cohorts patients ageing due successful treatment hiv infection combination antiretroviral therapy report case digoxin toxicity hiv positive year old man due combination drug drug interaction renal impairment first case report digoxin toxicity due drug drug interaction ritonavir hiv positive woman published best knowledge similar case report since published literature case alerts profession importance drug drug interaction highlights clinical features digoxin toxicity
dry eye increasingly common disease modern society affects wide range population negative impact daily activities working computers driving diagnosed automatic clinical test tear film lipid layer classification based color texture analysis researchers mainly focused improvement image analysis step however still large room improvement machine learning side paper presents methodology optimize problem means class binarization feature selection classification methodology used baseline classification problems provide several solutions evaluate performance using set representative metrics decision making methods several decision making methods used may offer disagreeing rankings solved conflict handling rankings merged single one experimental results prove effectiveness proposed methodology domain also general purpose allows adapt classification problems different fields medicine biology
dryland vegetation developed morphological physiological strategies cope drought however aridity increases vascular plant coverage gets sparse microbially dominated surface communities msc comprising cyanobacteria algae lichens bryophytes together heterotropic bacteria archaea fungi gain relevance nevertheless relevance msc net primary prodtictivity rarely considered ecosystem scale studies detailed information contribution total photosynthetic biomass reservoir largely missing study mapped spatial distribution two different msc biological soil crusts quartz fields hosting hypolithic crusts two different sites within south african succulent karoo soebatsfontein knersvlakte characterized types msc terms chlorophyll content combining data biocrust quartz field maps estimated total biomass values mscs spatial patterns within two different ecosystems results revealed msc important vegetation components south african karoo biome revealing clear differences two sites soebatsfontein msc occurred biological soil crusts biocrusts covered one third landscape reaching overall biomass value similar chlorophyll landscape scale knersvlakte characterized harsher environmental conditions higher solar radiation potential evapotranspiration msc occurred biocrusts also formed hypolithic crusts growing lower soil immersed parts translucent quartz pebbles whereas chlorophyll concentrations biocrusts hypolithic crusts insignificantly lower knersvlakte overall msc biomass reservoir far larger similar chlorophyll thus complementary microbially dominated surface communities promoted biomass formation within environmentally harsh knersvlakte ecosystem elsevier rights reserved
dual boundary integral equation bie developed problems containing degenerate boundaries hong chen journal engineering mechanics asce termed dual boundary element method bem portela international journal numerical methods engineering near years dual bie bem problem containing zero thickness barrier revisited mathematically study rank deficiency viewpoint updating term updating document singular value decomposition svd journal mechanics paper revisit dual bem physical point view although zero thickness barrier real world always required simulate finite thickness degenerate boundary zero thickness comparison sea air earth scale example sheet pile screen crack problem thin airfoil breakwater modeled geometry zero thickness role dual bem evident since lafe journal hydraulics division asce used conventional bem model finite thickness pile wall geometrically approximate zero thickness barrier numerically yielding divergent solution contrary physically model finite thickness breakwater zero thickness barrier breakwater employed illustrative case demonstrate dual bem simulated zero thickness barrier yield acceptable results match experiment data comparison finite thickness using conventional bem finally single horizontal plate two dual horizontal plates vertical direction horizontal direction three illustrative cases tell dual bem necessary mathematics also physics
due engineering application intricacy flow rotating coiled duct become one challenging research fields fluid mechanics paper spectral based numerical study presented fully developed two dimensional flow viscous incompressible fluid rotating coiled rectangular duct emerging parameters controlling flow characteristics rotational parameter taylor number grashof number prandtl number pressure driven parameter dean number rotation duct center curvature imposed positive negative direction combined effects centrifugal coriolis buoyancy forces investigated detail two cases dean numbers case case positive rotation investigated unsteady solutions found chaotic flow turns steady state flow periodic multi periodic flows increased positive direction negative rotation however unsteady solutions investigated found unsteady flow undergoes various flow instabilities increased negative direction typical contours secondary flow patterns temperature distributions obtained several values found unsteady flow consists asymmetric two eight vortex solutions present study demonstrates role secondary vortices convective heat transfer found convective heat transfer significantly enhanced secondary flow chaotic flow occurs large enhances heat transfer effectively steady state periodic solutions study also shows strong interaction heating induced buoyancy force centrifugal coriolis instability curved channel stimulates fluid mixing consequently enhances heat transfer fluid elsevier ltd rights reserved
due network security situation affected threat degree network attacks significance network services frangibility network system situation evaluation values possess fuzzification uncertainty situation evaluation values real timely demand network security situation improved prediction model based clonal selection system cloud scgm model namely scgm model proposed used predicting time series network security situation scgm model scgm model viewed basic prediction model clonal selection principle used optimizing parameters scgm model order improving prediction precision proposed model experimental results show scgm model accurate scgm model provide effective prediction approach network security situation
due conventional teaching method mainly focus impartment memorization knowledge points initiative student activated still substantial room improving professional abilities including independent learning ability problem solving capability hands practical ability etc aiming improving teaching results computer programming courses practical mode classroom instruction diverse collaboration proposed paper teaching mode theoretical teaching learning closely integrated professional practice opening lab problems scientific research project course assessment emphasizes project evaluation instead paper test proper evaluation actual practice level students
due appearance new characteristics electric power industry widely interconnection high intelligent open interactive energy internet architecture put forward new requirements electric information network security prevention information security faced severe challenge present method information security extensive management model prevention system exist weak links paper put forward new model guide overall development information security work quantization risk indicator fuzzy intelligent analysis
due broadcast nature radio propagation wireless air interface open accessible authorized illegitimate users completely differs wired network communicating devices physically connected cables node without direct association unable access network illicit activities open communications environment makes wireless transmissions vulnerable wired communications malicious attacks including passive eavesdropping data interception active jamming disrupting legitimate transmissions therefore paper motivated examine security vulnerabilities threats imposed inherent open nature wireless communications devise efficient defense mechanisms improving wireless network security first summarize security requirements wireless networks including authenticity confidentiality integrity availability issues next comprehensive overview security attacks encountered wireless networks presented view network protocol architecture potential security threats discussed protocol layer also provide survey existing security protocols algorithms adopted existing wireless network standards bluetooth wimax long term evolution lte systems discuss state art physical layer security emerging technique securing open communications environment eavesdropping attacks physical layer several physical layer security techniques reviewed compared including information theoretic security artificial noise aided security security oriented beamforming diversity assisted security physical layer key generation approaches since jammer emitting radio signals readily interfere legitimate wireless users also introduce family various jamming attacks countermeasures including constant jammer intermittent jammer reactive jammer adaptive jammer intelligent jammer additionally discuss integration physical layer security existing authentication cryptography mechanisms securing wireless networks finally technical challenges remain unresolved time writing summarized future trends wireless security discussed
due increasing vulnerabilities cyberspace security alone enough prevent breach cyber forensics cyber intelligence also required prevent future attacks identify potential attacker unobtrusive covert nature biometric data collection keystroke dynamics high potential use cyber forensics cyber intelligence paper investigate usefulness keystroke dynamics establish person identity propose three schemes identifying person typing keyboard use various machine learning algorithms combination proposed pairwise user coupling technique show performance separate technique well performance combining two together particular show pairwise user coupling bottom tree structure scheme gives best performance concerning accuracy time complexity proposed techniques validated using keystroke data however techniques could equally well applied pattern identification problems also investigated optimized feature set person identification using keystroke dynamics finally also examined performance identification system user unlike normal behaviour types one hand show performance optimal expected
due limited range long charging time electric vehicles proper utilization stored battery energy crucial current methods electric vehicle range estimation help driver formulate driving strategy based trip parameters trip speed related power savings done predicting driving range based optimal trip parameters prior trip enabling driver formulate suitable driving strategy study proposes novel strategy presents number optimal trip speeds driver along total trip time corresponding predicted range optimal speeds obtained solving multi objective optimization problem maximized electric motor efficiency minimized power consumption two approaches calculate objective functions considered using constant battery voltage using battery voltage function state charge pareto optimal fronts obtained plot predicted range trip times optimal speeds created found shape fronts affected approach however range overestimated constant battery voltage used elsevier rights reserved
due manifold effects thyroid hormone across virtually organ systems complications associated thyroid dysfunction numerous diverse stresses encountered perioperative period may exacerbate underlying thyroid disorders potentially precipitating decompensation even death thus utmost importance clinician comprehend mechanisms thyroid disease may complicate surgery postoperative recovery cognizant effective means optimizing status thyrotoxic hypothyroid patients perioperatively article describes adverse effects thyroid dysfunction relate patient undergoing thyroid nonthyroid surgery recommends treatment approaches aimed decreasing perioperative risk
due massive parallel computing capability outstanding image signal processing performance cellular neural network cnn one promising type non boolean computing system outperform traditional digital logic computation mitigate physical scaling limit conventional cmos technology cnn originally implemented vlsi analog technologies operational amplifiers operational transconductance amplifiers neurons synapses respectively power area consuming paper propose hybrid structure implement cnn magnetic components cmos peripherals complete driving sensing circuitry addition propose digitally programmable magnetic synapse achieve positive negative values templates rigorous performance analyses comparisons optimal energy achieved based various design parameters including driving voltage cmos driving size comparable footprint area operation speed spintronic cnn projected achieve one order magnitude energy reduction per operation compared cmos counterpart
due proliferation web technology commerce evolved social commerce social commerce era consumers increasingly dependent look social support informational emotional online even making purchases study examines content consumer reviews fundamental construct social commerce topics expressed consumer reviews collected amazon com explored using machine learning technique latent semantic analysis study documents thematic differences positive negative reviews finds negative reviews report service related failures positive reviews relate product among things next informational support aspect social commerce explored identifying topics expressed reviews helpful purchase decisions findings demonstrate potential customers would like purchase product near future currently reading reviews intention decide whether buy product find negative reviews containing service failure information positive reviews containing information core functionalities technical aspects aesthetics helpful theoretical managerial implications discussed elsevier ltd rights reserved
due quick growth data created analyzed industry business requirements become complex many companies come employ one key value store together serve different tasks considering key value stores currently define interfaces different attributes semantics interoperability among key value stores weak get best interoperability may choose store whose interfaces similar others may define interface specification sql specification relational databases propose interface description model idm short abstract interfaces different key value stores algorithm quantify differences named conversion cost help algorithms measure compare interoperability given two stores studying interoperability many stores propose interface prototype minimum conversion cost interfaces stores reference interface specification key value store experiments show features interfaces prove proposed prototype best interoperability typical stores elsevier rights reserved
due wide range water levels reservoir operation hydraulic functionality free surface tunnels supercritical flow conditions discharging beyond design conditions deserve studies investigate safe discharging low drop tunnels scale model spillway system built tested different flow conditions structural configurations water depth velocity flow regime tunnel flip bucket reach measured experiments emptying reservoir operations surprising phenomenon observed specifically low discharges supercritical flow occurred inside tunnel subcritical flow characterized exit section hydraulic jump forming moving back tunnel forcing work pressure critical discharge conditions hydraulic jump occurs tunnel theoretically derived hydraulic analytical computation experimentally confirmed eliminate risk choked tunnel modification envisioned setting torsion angle side weir along flip bucket section experiment results indicate combination skewed flip bucket side weir effectively decrease outlet water depth mitigate hydraulic jump avoiding tunnel choking thanks redirecting flow side weir centrifugal force effects ski jump flow skewed flip bucket downstream river regime also improved
due high peak performance energy efficiency massively parallel accelerators gpus quickly spreading high performance computing large amounts floating point data processed transferred stored environments greatly benefit data compression done sufficiently quickly unfortunately conventional compression algorithms unsuitable highly parallel execution fact generally unknown design good compression algorithms massively parallel systems remedy situation study lossless compression algorithms single double precision floating point values built exclusively easily parallelizable components analyze best algorithms explain compress well derive massively parallel compression mpc algorithm novel algorithm requires almost internal state achieves heretofore unreached compression ratios several data sets roughly matches best cpu based algorithms compression ratio outperforming one two orders magnitude throughput
actual drilling process wellbore pressure might critical pressure rock surrounding wellbore begins fail therefore optimizing wellbore trajectory based critical pressure improve wellbore stability may unreasonable critical pressure reflect degree difficulty initial damage occur wellbore rather extent wellbore damage accordance linear poroelastic rock mechanics theory combined mogi coulomb criterion shape initial shear failure zone arbitrary wellbores simulated order predict degree wellbore damage initial shear failure location failure width failure depth arbitrary wellbores determined new model calculating initial collapse volume directional wellbore derived paper help computer programming failure position critical pressure failure depth failure width initial collapse volume arbitrary wellbores different situ stresses analysed results show wellbore trajectory optimized according critical pressure significantly different optimized according degree wellbore damage trajectories completely opposite case southwest sichuan shows wellbore pressure critical pressure drilling process new model provided paper used optimizing wellbore trajectory ensure safety drilling operation elsevier rights reserved
brain damage ischemia cytokine interleukin beta rapidly upregulated due activation inflammasomes studied whether interleukin beta influences cortical spreading depolarization whether lipopolysaccharide often used microglial stimulation influences cortical spreading depolarizations anaesthetized rats cortical spreading depolarizations elicited microinjection kcl interleukin beta receptor antagonist gaba receptor blocker bicuculline lipopolysaccharide administered either alone combined interleukin beta receptor antagonist interleukin beta bicuculline lipopolysaccharide receptor antagonist local cortical treatment area using microelectrodes cortical spreading depolarizations recorded non treatment treatment area plasma extravasation cortical grey matter assessed evans blue local application interleukin beta reduced cortical spreading depolarization amplitudes treatment area high dose reduction prevented receptor antagonist bicuculline however interleukin beta induced pronounced plasma extravasation independently cortical spreading depolarizations application lipopolysaccharide reduced cortical spreading depolarization amplitudes prolonged duration eeg activity still present effects also blocked receptor antagonist interleukin beta evokes changes neuronal activity vascular functions thus although reduction cortical spreading depolarization amplitudes lower doses interleukin beta may reduce deleterious effects cortical spreading depolarizations sum interleukin beta effects excitability vasculature rather promote brain damaging mechanisms
fasting animals rely mixture fats carbohydrates proteins derived solely endogenous sources relative contributions metabolic fuels chiefly depend duration fast factors including previous diet environmental temperature activity level modulate fuel mixture long held endogenous proteins spared catabolism final stages prolonged fasting contribute significant proportion energy metabolic fuels depleted however evidence mounting protein catabolized supplemental fat metabolism circumstances shown migratory birds exhibit dramatic reductions lean mass flights one hypothesis explain seemingly maladaptive metabolic strategy catabolism oxidation protein situ yields five times metabolic water generated fat oxidation alone recent support hypothesis birds benefit strategy due uricotelic nature however remains unclear whether ureotelic mammals would also employ strategy test protein water hypothesis resting laboratory mice subjected water deprivation fasting tracked rates protein lipid catabolism using endogenously incorporated leucine palmitic acid found differences instantaneous leucine oxidation however cumulative differences instantaneous leucine oxidation ultimately resulted higher total leucine oxidation fasting water deprived animals also found lipid oxidation higher hydrated mice difference significant presumably concomitant reduction metabolic rates water deprived mice results indicate mammals increase rates protein catabolism dehydration lesser degree birds ability mammals produce highly concentrated urine lower inherent rates protein turnover apparently preclude mammals taking full advantage protein water strategy fasting dehydrating conditions
four days prenatal development mouse morphology first lower molar moves early cap bell stage five phenomena characterize period growth tooth germ development cervical loop histogenesis enamel organ folding epithelial mesenchymal junction associated cusp formation change cellular heterogeneity mesenchyme processes controlled epithelial mesenchymal interactions complex histo morphogenetic events documented using histological sections reconstructions combined functional tests vitro approach allowed searching possible relationships simultaneous changes occurring epithelial ecto mesenchymal compartments parallel changes occur two tissues could result different mechanisms illustrated increasing number pre odontoblasts pre ameloblasts crown growth cell division involved mainly ecto mesenchyme proliferation cell organization occurred inner dental epithelium reconstructions also raised still unsolved questions possible relationship cusp size spatial specification cell kinetic parameters changes cell position within inner dental epithelium tracing cell migration mesenchyme development
political elections voters rely various cues signal good social leadership indicators physical strength masculinity adult men masculine traits related testosterone levels one traits low pitched voice hence lower pitch presidential candidate may related election outcome prediction supported experimental evidence showing people prefer vote candidate low pitched voice aim study investigate relationship presidential candidates vocal characteristics actual election outcomes presidential elections held across world analysis voices opposing candidates results showed winners lower pitched voices less pitch variability moreover regression analysis revealed interaction effect voice pitch voice pitch variability election outcome candidates lower pitched voices greater likelihood winning election higher pitch variability study extends previous findings shows importance assessing vocal characteristics voice pitch offers external validity experimental evidence candidates vocal characteristics related election outcome elsevier inc rights reserved
domestication canids humans selected particular traits selected others wild canids phylogenetically primitive breeds might expected show less desirable traits recently derived european breeds dog order examine divided domestic dog breeds according apparent genetic relatedness wolf compared wild canid dingo using validated behavioural assessment tool barq sample included dingoes modern dogs ancient dogs overall number differences discovered breed groups accounting demographic effects variability breeds dingoes significantly less trainable ancient modern dogs displayed greater stranger directed fear non social fear modern dogs dingoes also prone escaping roaming urinating objects modern dogs tended exhibit compulsive staring rolling animal droppings ancient modern dogs using multivariate test found dingoes represented significant outlier range typical breed variation domesticated dogs taken together results provide evidence selective processes domestication reflected behaviour dog breeds primitive breed behaviour tends reflect earlier different selection pressures natural rather artificial selection elsevier rights reserved
folding process substrates exposed high localized stresses case coated papers boards lead decreased aesthetic features complete loss functionality production efficiency folding process could improved automated computer vision based inspection system task different existing computer aided fold crack evaluation approaches analyzed detailed research conducted propose image processing based fold cracking assessment via finding optimal sample preparation digitization techniques developing algorithm digital image analysis feature extraction analysis applicability different sample preparation digitization parameters well proposed digital image feature done correlation evaluation one way analysis variance anova corresponding post hoc tests results indicated developed algorithm fulfils set requirements proposed feature digitized samples faithfully describes analyzed fold cracks elsevier ltd rights reserved
heroic age antarctic exploration number early explorers developed psychiatric illness either antarctic shortly leaving psychotic illnesses stress reactions least six explorers committed suicide either antarctic return cases described possible reasons apparent high incidence psychiatric disease suicide discussed also examples possible misuse psychiatric labels
last decade leadership energy environmental design leed rating system embodied efforts green building council usgbc recognize buildings designed achieve superior performance several areas including energy consumption given emergent interest improving buildings energy efficiency researchers generated predictive physical data driven models energy consumption although physical approaches aiming calculate energy consumption behavior building level accurate necessity continuously inspecting gathering data input parameters often makes approaches impractical applications objective study introduce novel assessment method investigates correlation leed certification actual energy consumption investigating case study leed certified research buildings climate zone research approach first consists developing testing eight performance models non leed buildings inspecting fit best model five comparable leed certified buildings heating cooling electricity data collected buildings addition multiple weather time building characteristics variables data used generate several regression models predict energy consumption conventional research buildings results show differences energy use leed non leed buildings large anticipated paper contributes body knowledge first introducing novel generic assessment method leed buildings second applying method case study sample leed certified research buildings climate zone findings paper support actual performance assessment leed buildings helping practitioners make better decisions throughout project life order ensure fair representative assessment leed certification system future studies invited adopt new method comparing actual performance leed buildings non leed buildings american society civil engineers
last decades photogrammetric computer vision systems well established scientific commercial applications recent developments image based reconstruction systems resulted easy way creating realistic visually appealing accurate models present fully automated processing pipeline metric geo accurate reconstructions complex geometries supported online feedback method user guidance image acquisition approach suited seamlessly matching integrating images different scales different view points aerial terrestrial different cameras one single reconstruction evaluate approach based different datasets applications mining archaeology urban environments thus demonstrate flexibility high accuracy approach evaluation includes accuracy related analyses investigating camera self calibration georegistration camera network configuration elsevier inc rights reserved
last decades focus food nutrition security research shifted issues macro level availability problems unequal access distribution within household little systematic attention however paid role family systems household food allocation processes study focuses extent family relations particularly gender roles two himalayan communities different family systems influence intra household food allocation subsequent nutritional status women reproductive age depth interviews conducted buddhist hindu women latter belonging either higher chhetri lower dalit castes additionally anthropometric data women collected results show women hindu families worse women buddhist households terms nutritional status due different intra household allocation patterns secondly women nutritional status varied reproductive life course women vulnerable menses pregnancy post partum period comparison research conducted area suggests influence family level values practices women nutritional status slowly changing
last two decades third wave computing emerged move model accessing internet internetworks almost exclusively via desktop computer alternative forms distributed information technologies smartphones wearable computers sensors microprocessors embedded everyday objects paper undertakes critical review literature offers discusses definitions third wave surprisingly area innovation definitions evolving overlapping inconsistent paper analyses consolidates literature order identify key aspects new phenomenon coined term eobjects central element third wave paper presents framework research technologies implications distinguishing core common attributes identifying categories inter device interaction subsequent paper apply research framework legal research intention understanding areas litigation anticipated uncovering areas law may adequately deal emergent social business practices kayleen manwaring published elsevier ltd rights reserved
last years several studies construction materials incorporation encapsulated phase change material pcm published however utilization non encapsulated pcm one main gaps main objective work study physical mechanical properties cement mortars incorporation non encapsulated pcm possible conclude utilization non encapsulated phase change materials seen good economical solution energy efficiency buildings without prejudice properties elsevier ltd rights reserved
operation stage parallel bridges may become nonparallel result unequal load distribution two parallel bridges special conditions aerodynamic performance could change significantly nonparallel positions become different parallel positions paper stationary aerodynamic performance two parallel bridges various nonparallel positions operation stage studied series wind tunnel tests includes investigation two horizontal gap distances hgds five relative vertical displacements rvd five relative torsional displacements rtd first sectional models two closed box girders tested smooth flow stationary aerodynamic force coefficients optimum iteration method used calculate structural displacements torsional divergence critical wind velocities two assumed suspension bridges stationary aerodynamic force research outcomes demonstrated changes stationary aerodynamic force coefficients dependent relative displacements two girders wind attack angles addition revealed interference effects detrimental stationary aerodynamic instability two bridges larger gap width ratio related aerodynamic shape girders bridge structures ucr leeward bridge significantly decline vertical position leeward bridge become higher windward bridge importantly showed combination rvd rtd rvd rtd degrees could potentially lead worst stationary aerodynamic performance decreasing windward leeward bridge respectively
past decades polymeric micelles raised special attention novel nano sized drug delivery systems optimizing treatment diagnosis numerous diseases nanocarriers exhibit several vitro vivo advantages well increased stability solubility hydrophobic drugs interesting approach optimizing properties overcoming disadvantages combination two polymers order assemble polymeric mixed micelles review article gives overview current state art several mixed micellar formulations nanocarriers drugs imaging probes evaluating ongoing status preclinical clinical stage special emphasis type copolymers physicochemical properties vivo progress achieved far toxicity profiles besides present article presents relevant research outcomes polymeric mixed micelles better drug delivery systems compared polymeric pristine micelles reported data clearly illustrates promise nanovehicles reaching clinical stages near future elsevier rights reserved
dynamic environmental modelling spatio temporal systems often requires representation fields agents fields continuous values whole spatio temporal domain model agents bounded space often mobile currently difficult environmental modellers limited software engineering background construct field agent models modelling frameworks mostly support integration fields agents overcome issue describe data model combining fields agents single concept data model represents fields agents relations grouping items sharing properties phenomenon concepts domain property set value handle spatio temporal attribute representations data model implemented software prototype shows data fields agents stored manipulated elsevier ltd rights reserved
dynamic programming algorithm design technique difficult learn apply paper introduce two extensions recursion visualization system srec intended support dynamic programming firstly srec supports generation recursion forests structured collections recursion trees enhance understanding complex multiple recursive algorithms secondly srec supports phases systematic development dynamic programming algorithms checking recursion redundancy generation dependency graph associated recursion tree matching graph table facilities require high degree interactivity effective paper illustrates new facilities dynamic programming algorithm sequence alignment problem successfully applied new version srec number algorithms currently using course con advanced algorithms
dysfunction iron metabolism includes uptake storage release plays key role neurodegenerative disorders including parkinson disease alzheimer disease huntington disease understanding iron accumulates substantia nigra specifically targets dopaminergic daergic neurons particularly warranted knowledge may provide new therapeutic avenues targeted neurotherapeutic strategy disease review begin brief introduction describing brain iron metabolism regulation provide detailed description iron accumulates specifically daergic neurons especially vulnerable iron furthermore focus possible mechanisms involved iron induced cell death daergic neurons finally present evidence support iron chelation represents plausable therapeutic strategy
earlier studies demonstrated strong relationships manual assembly high physical load levels increased amounts quality defects compared assembly low physical load levels recent swedish interview study engineers design manufacturing engineering indicated assembly complexity factors additional importance assembly quality objective study therefore examine significance high low complexity criteria relationships assembly ergonomics assembly complexity quality failures analyzing manual assembly tasks car manufacturing total cars analyzed results showed several significant correlations assembly ergonomics assembly complexity assembly time failures action costs action costs high complexity tasks times increased per task per car compared low complexity tasks relevance industry assembly ergonomics assembly complexity factors interact proactively considered order keep assembly related failures action costs low possible elsevier rights reserved
early childhood educators ece perceptions gender roles may contribute development children gender role identities qualitative study examined canadian female eces perceptions gender children shy aggressive prosocial behaviors content analysis extensive interviews revealed three themes shyness personality based influences behaviors teachers role addressing gender behavior eces believed shyness personality trait exhibited equally among genders displayed differently contrast inconsistencies gender perceived participants aggressive prosocial well findings suggested participants believed teacher role address behaviors within classroom help children express understand feelings discussion educational aids books videos community examples results discussed terms educational implications ece training
early enriched environment prevents several deficits associated postnatal methylo aspartate nmda receptor antagonist treatment cognitive locomotor deficits sought physiological correlates changes looking inhibitory synaptic inputs onto pyramidal cells prefrontal cortex slice preparation pharmacologically isolated gamma amino butyric acid gaba receptor mediated currents measured using whole cell patch clamp recordings wistar rats raised standard birth time experiments injected saline postnatal days recorded miniature inhibitory post synaptic currents mipscs pyramidal cells layer prefrontal cortex measured frequency amplitude kinetics control animals amplitude frequency mipscs increased strikingly development accelerated development mipscs frequency caused significant decrease amplitude mipscs suggesting significant reduction inhibition onto pyramidal cells per led significant increase frequency amplitude mipscs application treated rats resulted moderate rescue gabaergic transmission conclude postnatal leads reduced inhibitory transmission onto pyramidal cells prefrontal cortex adolescence may underlie behavioural morphological differences detected vivo rats presentation birth rather prevents gabaergic alterations associated postnatal treatment adolescence isdn published elsevier ltd rights reserved
early integration sustainability decisions mineralogical attributes design minerals processing units offers potential reducing environmental impacts mining processing sites objective study demonstrate integration sustainability indicators mineralogical attributes could achieved developing integrated modelling framework magnetic separator magnetic separator unit model based existing literature developed include process stream mineralogical data output sustainability indicators overall sustainability processing three ore types low medium high grade iron ore evaluated using developed model novel measures evaluating magnetic separation grade recovery deviation index grdi energy efficiency rotational energy transfer efficiency rete incorporate use ore characteristics developed study measures used calculate separation energy efficiency sustainability indicator ratings total eleven magnetic separator sustainability indicators identified indicator assigned weighting value based importance sustainability indicators identified safety reliability carbon dioxide emissions water use noise job creation ratings vary changing mineralogical attributes feed ore grdi rete electricity cost particle emissions waste generation ratings observed dependent ore characteristics therefore values varied different feed ore grades analytic hierarchy process ahp weighted sum method wsm methods applied sustainability indicator ratings weightings evaluate overall sustainability cardinal score processing particular ore feed results study demonstrate dependence overall process sustainability indicators feed ore mineralogical attributes results also provide indication effect ore variability typical within single deposit sustainability indicators elsevier ltd rights reserved
early onset ethanol consumption predicts later development alcohol use disorders age related differences reactivity ethanol effects may underlie effect adolescent rats sensitive less sensitive adults appetitive aversive behavioral effects ethanol respectively sensitive neurotoxic effects experimenter administered binge doses ethanol however less known age related differences neural consequences self administered ethanol delta fosb transcription factor accumulates chronic drug exposure serves molecular marker neural plasticity associated transition addiction analyzed impact chronic two bottle choice intake sessions spread across days session length ethanol vehicle control group self administration adolescence adulthood induction delta fosb several brain areas anxiety like behavior ethanol induced locomotor activity conditioned place preference cpp wistar rats adolescent rats exhibited progressive escalation ethanol intake preference whereas adult rats exhibited stable pattern ingestion behavioral differences open field light dark test observed intake test furthermore ethanol self administration promote expression ethanol induced cpp however large age related differences neural consequences ethanol drinking significantly greater number ethanol induced delta fosb positive cells found adolescents adults prelimbic cortex dorsolateral striatum nucleus accumbens core shell central amygdala nucleus capsular basolateral amygdala sex related differences found central amygdala greater ethanol induced delta fosb induction may represent yet another age related difference sensitivity ethanol may put adolescents higher risk problematic ethanol use elsevier inc rights reserved
earth observation data great interest wide spectrum scientific domain applications enhanced access remote sensing images domain experts thus represents great advance since allows users interpret remote sensing images based domain expert knowledge however advantage also turn major limitation knowledge formalized thus difficult shared understood users context knowledge representation techniques ontologies play major role future remote sensing applications implemented ontology based prototype automatically classify landsat images based explicit spectral rules ontology designed modular way order achieve generic versatile representation concepts think utmost importance remote sensing prototype tested four subsets landsat images results confirmed potential ontologies formalize expert knowledge classify remote sensing images
earthen masonry made compressed stabilized earth blocks csebs emerging sustainable locally appropriate construction material affordable high quality dwellings compelling features include local availability affordability suitable soils thermal insulation humidity control properties small embodied energy compared fired clay masonry mechanical properties csebs subject several investigations however research response design optimization cseb masonry building structures infancy significant knowledge technological gap exists regard resistance extreme loads due natural hazards high winds earthquakes necessary address gap understand whether engineered earth masonry enlisted respond growing demand hazard resistant dwellings also affordable sustainable paper discusses feasibility using earth masonry low rise dwelling structures withstand extreme winds hurricanes tornadoes periodically scourge vast areas central north america caribbean low income families live demand sustainable construction meets structural resistance affordability feasibility studied based structural analysis main wind force resisting system mwfrs typical one story single family dwelling subject wind pressures resulting gust speeds output consists parametric curves relate wind speed masonry compressive tensile shear strength demand wall thicknesses ranging structural adequacy mwfrs assessed cases flat gable roof design implications discussed vis vis strength reduction factors design strength demands sustainable reinforcement options concluded feasible design one story cseb masonry dwellings withstand winds loads category hurricanes tornadoes provided rigid horizontal diaphragm used grouted steel reinforcement may used safety shelter cseb masonry structures designed extreme wind loads elsevier ltd rights reserved
eating disorders related symptoms occur midlife however little known aetiology hypothesised perimenopause represents window vulnerability development exacerbation eating disorder symptomatology like puberty perimenopause period reproductive hormone change compared symptoms bulimia nervosa bulimic symptomatology assessed via mean scores self report questionnaire premenopausal perimenopausal women also examined association hormone concentrations reproductive appetite bulimic symptomatology mean differences bulimic symptomatology observed premenopause perimenopause however significant positive association leptin binge eating although significant associations reproductive hormones bulimic symptomatology observed additional research needed provide definitive information essential learn aetiology eating disorders related symptomatology across lifespan order develop age relevant treatment prevention programs copyright john wiley sons ltd eating disorders association
cigarettes remain controversial scientific evidence short term long term effects tolerance health value switch tobacco cigarettes contested controversial nevertheless quality cigarettes liquids improved main ingredients propylene glycol vegetable glycerine nicotine pharmaceutical grade quality liquids flavors almost food grade high quality ingredients decreased presence impurities liquids emissions cigarettes contain solid particles carbon monoxide nitrosamine content least one hundred times lower tobacco smoke cigarette emissions normal use contain harmful constituents significant levels except nicotine public health authorities stated cigarette use likely least less toxic cigarette use benefits well regulated legal market countries liquid containing nicotine allowed liquids common handling risks may sometimes contain toxic impurities though cigarettes never assumed safe products non smokers smokers cigarette least times less dangerous cigarette tobacco cessation specialists countries nicotine containing cigarettes available increasingly provide counselling cigarette use stop smoking reduce smoking request patients based current knowledge patients lung forms cancer would otherwise continue smoke cigarettes offer alternative way quit smoking undergo medical treatment elsevier ireland ltd rights reserved
ecology ecotoxicology different historical roots despite similar names slowly converging meet challenge addressing massive global proliferation release chemicals environment conceptual methodological review standard research papers special issue reflect emerging trend blending ecological ecotoxicological perspectives assess impacts freshwater ecosystems assessing community ecosystem impacts chemical contaminants complex however require approaches explicitly consider biological chemical diversity well natural variability environmental factors multiple spatial temporal scales central themes papers issue importance indirect effects chemical contaminants species interactions food webs effects multiple stressors especially interactions contaminants environmental factors iii consequences chemical exposure ecosystem processes primary production litter decomposition need account context dependency potentially harmful community ecosystem effects emerging contaminants among nanoparticles prominently represented collectively papers show integrating ecological principles design implementation ecotoxicological research essential assessing predicting contaminant impacts biological communities ecosystems conversely applied ecology bioassessment would benefit concepts approaches developed ecotoxicology fully embracing chemical contaminants key drivers community structure ecosystem processes
economic games offer convenient approach study prosocial behavior advantage allow straightforward implementation different techniques reduce socially desirable responding investigated effectiveness prominent techniques namely providing behavior contingent incentives maximizing anonymity three versions trust game hypothetical version without monetary incentives typical level anonymity incentivized version monetary incentives typical level anonymity iii indirect questioning version without incentives maximum level anonymity rendering responses inconclusive due adding random noise via randomized response technique results large heterogeneous sample showed comparable levels trust hypothetical incentivized versions using direct questioning however levels trust decreased maximizing inconclusiveness responses indirect questioning implies levels trust might particularly sensitive changes individuals anonymity necessarily monetary incentives
ecosystem modeling critically important tool environmental scientists yet rarely taught undergraduate graduate classrooms address gap developed teaching module exposes students suite modeling skills tools including computer programming numerical simulation modeling distributed computing students apply study lakes around globe experiencing effects climate change module students develop hypotheses effects different climate scenarios lakes test hypotheses using hundreds model simulations taught module hour workshop found participation module significantly increased undergraduate graduate students understanding climate change effects lakes moreover participation module also significantly increased students perceived experience level using different software technologies modeling tools embedding modeling environmental science context non computer science students able successfully use master technologies previously never exposed overall findings suggest modeling powerful tool catalyzing student learning effects climate change
eczema herpeticumin immunocompromised cancer patients identified treated early life threatening commonly found patients skin integrity disorders atopic dermatitis immunocompromised patients herpes simplex type infection trunk head neck regions commonly involved early antiviral therapy crucial immunocompromised hosts prevent rapid progression infections present case adult generalized eczema herpeticum review differential diagnosis management options
eczema frequent childhood manifestation atopic children allergic certain foods aeroallergens anxious parents atopic children often fear topical steroid related side effects may try range elimination diets avoid allergies elimination diets increase risk anaphylaxis exposure previously tolerated foods loss oral tolerance unbalanced diets together inadvertent excessive consumption fruits vegetables may lead carotenemia carotenoids plant foods carotenemia benign unusual diets consumption preformed vitamin health supplements lead vitamin toxicity discuss child eczema exclusion diet presenting anaphylaxis dairy food carotenemia hepatomegaly resolved dietary management
education democratic south africa saddled extraordinary task sanitising dehumanising splintered education system singular narrative social justice creative problem solving individuals extraordinary effort witnessed pendulum swing openness outcomes based education less flexible national curriculum statement recently criticised restrictive curriculum assessment policy statement caps narrow focus assessment learning caps appears trapped particular understanding teaching learning understood terms measurement thereby discounting education happening outside measured article contend firstly education averse measurement allowed dominate educative process instead possible reconcile measurement expressed language needs language coming presence recognises learners enter education arena ideas known yet known secondly argue post apartheid education system hopes humanise citizens society possible cultivating curriculum understood process socially encountersone always becoming therefore necessarily measurable
education management information system emis widely acceptable developing technology within information technology field advancement technology century collaborated scientific invention explorer information strengthening development paper presents results experiences gained applying students oriented emis monitoring managing mental health mental health students depends acquiring adequate knowledge basic concepts within time period academic schedule obviously significance evaluate appraise stress stimulators challenge threat theoretical framework study designed analyzing stress stimulators academic performance emis accessibility sample examined study stratified random sample students specifically engineering college dindigul district tamilnadu primary factor academic stress stimulators form one module emis key variable curriculum instruction related stressors placement related teamwork related assessment related mental health related stress stimulators namely curriculum syllabus placement related assessment related team work related significant influence academic performance students various institution important factor leading emis application monitoring stress stimulators curriculum syllabus related assessment related
educational administration rich domain scholarship practice one subject rarely discussed dark side study explored question types maladministration occur schooling systems goal develop findings inform existing prevention strategies focused canadian context data sources included reports disciplinary hearings administrators provinces ontario british columbia complemented publicly available sources news stories findings indicated small minority populations administrators subjected disciplinary investigations sanctions targeted misconduct often severe analysis revealed eight dimensions maladministration sexual misconduct students financial transgressions frequent academic dishonesty context standardized testing gendered patterns maladministration also stood typology emerged highlighted main forms misconduct negative leader behaviours schooling communities bolster defences populated data frequencies acts maladministration typology help schooling communities establish prevention priorities data study supports making issues sexual misconduct duty report sexual abuse central planned interventions leadership system
educational context undergone several changes mainly driven contemporary lifestyle fast progress field computing information communication technologies ict increasingly present important daily life therefore incorporation technologies education became frequent enabling number innovative exciting experiences achievement learning various fields knowledge within scenario distance learning highlighted type education thrives technological advances sharp integration human computers computer systems distance learning broadened horizons mainly adult education within undergraduate graduate professionalization area example professionals intense work journeys face difficulties join continuing education facilities offered distance learning flexible working hours place studies represent solution health area initiatives grown considerably due advantages brazil government focused distance learning offer continuing medical education professionals within public health care network open university brazilian national health system una sus works partnership public universities several states maranhao support federal university state ufma una sus developed various mechanisms educational tools facilitate learning distance learning among possible highlight educational electronic games created institution provide realistic interactive study experiences seeking integrate specific play activities make learning dynamic creative fun games developed able provide motivating attractive atmosphere teaching simulating practical situations encouraging development strategies solutions decision making therefore contributing construction concepts psychomotor function stimulation games developed una sus ufma match storytelling genre following comic book format using player interaction complete story paper aims expose game production process developed una sus ufma address issues related area nephrology subject one courses offered institution object question developed using unityd graphics engine allows quick easy implementation multi platform games also facilitates creation interfaces gameplay mechanisms animations thus reducing time required development also listed advantages using game question address nephrology well potential weaknesses production use learning object creation learning objects one presented work contributes significantly development distance learning therefore cooperating democratization expansion knowledge
effective interpersonal communication depends ability perceive interpret nonverbal emotional expressions multiple sensory modalities current theoretical models propose visual auditory emotion perception involves network brain regions including primary sensory cortices superior temporal sulcus sts orbitofrontal cortex ofc however relatively little known dynamic interplay regions gives rise perception emotions recent years increasing recognition importance neural oscillations mediating neural communication within functional neural networks review studies investigating changes oscillatory activity perception visual auditory audiovisual emotional expressions aim characterize functional role neural oscillations nonverbal emotion perception findings reviewed literature suggest theta band oscillations consistently differentiate emotional neutral expressions early theta synchronization appears reflect initial encoding emotionally salient sensory information later fronto central theta synchronization may reflect integration sensory information internal representations additionally gamma synchronization reflects facilitated sensory binding emotional expressions within regions ofc sts potentially amygdala however evidence ambiguous comes role oscillations within alpha beta frequencies vary function modality modalities presence absence predictive information attentional task demands thus synchronization neural oscillations within specific frequency bands mediates rapid detection integration evaluation emotional expressions moreover functional coupling oscillatory activity across multiples frequency bands supports predictive coding model multisensory emotion perception emotional facial body expressions facilitate processing emotional vocalizations
effective solar energy harvesting charge carrier separation two key factors photocatalysis system work heterojunction photocatalyst cds cowo fabricated facile hydrothermal method compared pristine cds cowo cds cowo heterojunction photocatalyst showed enhanced photocatalytic activity methylene blue degradation visible light irradiation particularly sample molar ratio cds cowo sample controlled showed highest degradation ratio among samples times pure cds times pure cowo respectively greatly enhanced photocatalytic activity times cds cowo due efficient separation electron hole pairs heterojunction structure strong visible light absorption cds work provides new insight application tungstate based heterojunction photocatalysts environmental remediation
effective surface treatments suppress possible recombination losses confine photogenerated electrons holes within bulk silicon wafer thus maximizing number electrochemical potential deliver load happen necessary create regions high conductivity one carrier low basis separation common thread joining surface passivation carrier selective contacts principles apply one manipulation concentrations electrons holes achieved doping depositing materials appropriate bandgap work function conductivity method use hydrogen rich semi insulators bond chemically silicon atoms used part contact structure need sufficiently thin permit current flow examples passivated contacts dopant diffusions coated thin insulators doped polysilicon sio structures transparent conductors
effects chitosan trans resveratrol glycine betaine dipping quality biochemical changes sukkarf bananas studied ripening shelf life conditions days weight loss increased shelf life affected treatments peel color index increased lower resveratrol treatments control membrane stability index msi peel decreased higher especially days resveratrol treatments control firmness decreased higher especially days resveratrol low moderate rates control tss increased lower treatments control acidity concentration decreased higher especially days low rate chitosan resveratrol high rate control increased higher low rate lower low moderate rates resveratrol control vitamin concentration decreased affected treatments total phenols concentration decreased higher moderate rate resveratrol control total flavonoids concentration decreased lower resveratrol low high rates control frsc dpph increased lower low moderate rates resveratrol treatments especially days relations biochemical changes alpha amylase xylanase polygalacturonase peroxidase polyphenoloxidase activities discussed conclusion postharvest trans resveratrol treatments retained quality sukkari bananas suggested natural alternatives synthetic chemicals elsevier rights reserved
effects sex handedness production spontaneous click evoked otoacoustic emissions oaes explored non hearing impaired population ages years sex difference oaes either produced spontaneously spontaneous oaes soaes response auditory stimuli click evoked oaes ceoaes reported infants children healthy young adults seldom target study current data robust sexual dimorphism confirmed women producing numerous stronger soaes ceoaes greater response amplitude compared men right ear advantage found number soaes produced women soae power although handedness moderate ear asymmetry production exploratory analyses revealed departures strong right hand preference associated present sample reduced numbers strengths oaes results discussed respect differential exposure androgens prenatal development elsevier inc rights reserved
efficient charge separation vital factor gain high photocatalytic activity alternative spatial electric field generated piezoelectric effect could significantly accelerate charge separation introduced photocatalyst system work famous piezoelectric lead magnesium niobate lead titanate pbtio pmn firstly constructed tio prepare composite photocatalyst pmn tio results indicate alternative spatial electric field excited ultrasonic wave vibration greatly improves photocatalytic degradation efficiency rhodamine rhb pmn tio durability experiments suggest pmn tio keep excellent photocatalytic stability even several runs moreover photocatalytic degradation methylene blue enhancement effect alternative spatial electric field photocatalytic performance also observed importantly study provides general method constructing piezoelectric based photocatalyst capture solar energy acoustic wave energy wind energy realize multi field energy coupling high photocatalysis elsevier rights reserved
efficient control irrigation systems depends attaining representative water status data irrigated field spatial variability soil hydraulic properties root growth patterns hamper use single value representations work proposes two pronged approach designed determining optimal sensor location irrigation water management combines experimental results offer method pre determining root growth patterns modeling analysis effect tensiometer location coefficient variation matric head measurements irrigation system operation investigated experimental part effect geotextile material wrapped around drippers along drip line create geotextile drip interface gdi root growth patterns field evaluated results showed higher root density around gdi regular buried drippers well defined peak root density former one location peak root density latter genetic root architecture smaller effect root distribution gdi treatment modeling part consisted hydrus simulations high frequency subsurface drip irrigation heterogeneous soils gdi root distribution observed experiment simulations explored different locations tensiometer placement result low variability system operation hydrus simulations showed optimal location tensiometer placement near subsurface dripper resulting low matric head measurements applied irrigation water high sensitivity irrigation lower drainage root zone overall results show measuring soil water status tensiometers located close drippers gdi volume improve control high frequency irrigation systems allow greater water application efficiency drip irrigated fields elsevier rights reserved
egg allergy one common food allergies childhood along cow milk allergy measles mumpsrubella mmr vaccine included pediatric immunization schedule contains egg protein currently accepted opinion mmr vaccination done single dose medical observation patients egg allergy although reported mmr vaccine safe patients patients developed anaphylaxis generally development anaphylaxis previous vaccination reported contraindication present successful administration mmr vaccine gradually increased doses patient developed anaphylaxis previous vaccination
either cardiovascular peripheral vascular diseases become major cause morbidity mortality worldwide recently growth factors therapeutics whatever administrated form exogenous growth factors relevant genes discovered effective strategy prevention therapy vascular diseases promoting angiogenesis besides alternative stem cell based therapy also developed view paracrine mediated effect ability differentiation toward angiogenesis related cells assistance growth factors despite specific potent matter growth factors stem cells based therapy full clinical transformation limited bench bedside review potential choices therapeutic modes based types different growth factors stem cells firstly summarized vascular diseases confronted various challenges lack non invasive delivery method physiochemical challenge short half life time poor cell survival carefully analyzed therapeutic modes various strategies overcome limitations put forward perspective drug delivery expertised design suitable delivery form undoubtedly provide valuable insight clinical application regenerative medicine
electric machines corresponding power electronic drives key components electric hybrid electric vehicle hev powertrains thus computationally efficient models electric machines drives essential powertrain level design simulation optimization paper finite element based method quickly generating torque speed curves efficiency maps electric machines drives presented first magneto static finite element analysis fea conducted base machine design analysis produces normalized torque flux linkage current losses operating points interest values adjusted based upon changing size machine effective number turns machine windings quickly generate variety new machine designs corresponding efficiency maps results suggest proposed techniques useful hev powertrain design optimization
electric mobility playing important growing role context sustainable transport sector development study presents life cycle assessment electric car based technology lithium ion battery bev europe compares internal combustion engine vehicle icev according cradle grave approach manufacturing use disposal phases vehicles included assessment order identify hot spots entire life cycles electric vehicles two manufacturing inventories analysed different vehicle disposal pathways also considered furthermore environmental performances hybrid vehicles analysed based life cycle models bev icev results hot spot analysis showed bev manufacturing phase determined highest environmental burdens mainly toxicity categories result use metals battery pack however greenhouse gas emissions associated bev use phase shown half recorded icev use phase trend results also investigated future energy mixes electricity diesel mixes year considered modelling use phase bev icev institution chemical engineers published elsevier rights reserved
electric motor driving reciprocating compressor cause large power pulsations electric systems result necessary oversize protections circuit breakers fuses may require reactive compensation equipment increase voltage stability supply system reciprocating compressors driven synchronous asynchronous motors due characteristics peculiarities synchronous motors widespread studied compared induction motors recent years extensive use electric drives induction motors increasingly involved implementation compression trains first time analysis compression train made considering induction motor simple inertia synchronous motor recently effects air gap torque considered induction motor model allowing simulate accurately entire system paper transient power pulsation evaluation reciprocating compressor train based air gap torque effects electric motor presented analysis involves electrical parts mechanical parts multiphysics equations derived matlab simulink model realized finally verify proposed procedure real compressor train simulated
electric motors becoming increasingly popular propulsion control unmanned systems order optimize power generation energy use unmanned systems important understand dynamics electric motors corresponding powertrain paper provides early preliminary study electric motor used unmanned aerial systems uas electric motor dynamometer used collecting data motor trends discussed future work look implementing mathematical models unmanned ground system built experimentation
electric power system instantaneous frequency also referred electrical network frequency enf pollutes digital recordings due variety factors transformer hum unwanted interference used forensic tool conjunction database ground truth enf measurements determine time recording made well detect tampering recent work suggested enf could used geolocate digital recording assumption low energy location unique power system dynamics observable always case presence noise interference letter aims take advantage intrinsic nature power system instantaneous frequency order frame enf extraction problem one demodulation considering enf sinusoid nominal power system frequency frequency modulated weak stochastic signal intermediate frequency signal created analyzed rather direct measurements significant data reduction achieved extensive downsampling demodulation algorithms applied extract enf spectrum signal provides straightforward way estimating maximum observable frequency content enf buried digital recording findings supported analysis audio recordings made presence enf interference eastern interconnection power system
electric vehicles considered promising alternative internal combustion engine vehicles towards cleaner transportation sector null tailpipe emissions electric vehicles contribute fight localized pollution particularly important overpopulated urban areas however electric vehicle implies greenhouse gas emissions related production electricity generation needed charge batteries study focuses analysis electric vehicle emissions vary compared internal combustion engine vehicles depending electric power plant fleet efficiency use phase done global warming potential gwp associated electricity generation electric vehicle selling european countries calculated similarly electric vehicle use phase energy efficiency calculated wide range driving conditions using monte carlo method results energy production energy use phases compared gwp calculated internal combustion engine vehicles six different driving cycles obtain threshold values electric vehicles provide gwp reduction threshold values matched current electricity power plant fleet electric vehicle promotion incentives european countries considered study showing countries france norway better suited electric vehicles adoption countries like spain portugal boost electric vehicle promotion policies furthermore countries europe germany effort decarbonizing power plant fleet offer immediate greenhouse gas emission reductions uptake electric vehicles instead conventional cars elsevier ltd rights reserved
electrical machines especially combination modern power electronics driving horse industry traction automotive applications lot research ongoing fields new improved topologies better performance increased efficiency latter one requires better knowledge loss mechanisms machine order find solutions reduce iron losses resulting varying magnetization ferromagnetic lamination sheets complex loss component electrical machine one factor influencing iron losses significantly manufacturing process among different production steps punching machines lamination considered high impact magnetic properties knowledge properties depend mechanical process parameters considerable potential optimize process machine design increase machines efficiency paper present simulation models trying forecast losses punched lamination sheets therefore punching process simulated finite element software resulting distribution mechanical stress plastic strain incorporated jiles atherton model calculate magnetic hysteresis lamination sheet comparison measurements show applicability methodology
electricity generated using photovoltaic system commercial photovoltaic modules operate reliably years field conditions understanding performance degradation photovoltaic modules critical optimizing financial viability performance degradation photovoltaic modules due multiple factors installation site module technologies order gain insight performance degradation crystalline silicon technology harsh environment degradation effects study photovoltaic modules desert environment carried main contribution paper focused evaluation modules performance operated extreme environmental conditions evaluation usually consists curve field measurements visual inspections elsevier ltd rights reserved
electricity basic tool drives industrialization technological advancement engineering transformation economic growth world situation nigeria electricity power sector one defied virtually every effort made resurrect state dilapidation major concern ever stable cost effective electricity nigeria authors positive realised without considering forms electricity energy resources available nigeria conventional sources electricity currently mainstay deliberate transition conventional sources electricity energy renewable environmental friendly sources critical national development even though recent development show nigerian government backsliding adopting renewable energy technologies paper used highlight different sources renewable energy critical solve lingering problem electricity generation nigeria hence based literature modeled scenarios field experience authors discovered much easier individuals drive transition renewable energy continue depend government forever
electrochemistry coupled liquid chromatography mass spectrometry used simulating biological environmental fate polycyclic aromatic hydrocarbons pahs well studying pah degradation behavior electrochemical remediation pyrene benzo pyrene selected model compounds oxidized within electrochemical thin layer cell equipped boron doped diamond electrode atpotentials quinones found major oxidation products investigated pahs quinones belong large group pah derivatives referred oxygenated pahs gained increasing attention recent years due high abundance environment significant toxicity separation oxidation products allowed identification two pyrene quinone three benzo pyrene quinone isomers known formed via photooxidation mammalian metabolism good correlation electrochemically generated pah quinones formed natural processes also confirmed irradiation experiments microsomal incubations potentials higher degradation initial oxidation products observed highlights capability electrochemistry used remediation technique elsevier ltd rights reserved
electrocoagulation iron air fuel cell innovative arsenate removal system operate without external electricity supply thus technology advantageous treating wastewater remote regions difficult supply electricity study possibility real applications system arsenate treatment electricity production verified electrolyte effect investigations using small scale fuel cell performance testing liter scale fuel cell stack electrolyte species studied nacl naso nahco nacl overall effective electrolyte arsenate treatment although naso produced greatest electrical current power density addition although current density power density proportional concentrations nacl naso use concentrations nacl naso inhibited arsenate treatment due competition effects anions arsenate adsorption onto iron hydroxide dominant iron hydroxide produced iron anode found lepidocrocite means raman spectroscopy liter scale four stack iron air fuel cell nacl electrolyte found able treat ppm arsenate solution ppb day based min treatment capacity well produce maximum power density elsevier ltd rights reserved
electromagnetic design min high speed permanent magnet motor hspmm carried based analysis pole number stator slot number rotor outer diameter air gap length permanent magnet material thickness pole arc load full load performance hspmm investigated paper using finite element method fem addition power losses hspmm including core loss winding loss rotor eddy current loss air friction loss predicted based analysis prototype motor manufactured experimentally tested verify machine design
electromagnetic interference emi shielding effectiveness carbon foam containing different amounts silicon carbide nanowires sic nws determined band ghz carbon foam prepared powdered precursors containing polyurethane novolac pitch situ sic nws grown inside porous body using different weight ratios silicon powder ranging zero pyrolyzing degrees argon atmosphere decorated nanowires led different cellular structure compared pristine carbon foam improved absorptivity radiations due high level dielectric loss loss tangent ghz maximum emi specific shielding effectiveness similar ghz achieved carbon foam containing highest amount sic nws two times higher pristine carbon foam presence nws stacking faults heterostructure interfaces long tortuous paths carbon foam caused strong dielectric loss induced higher dielectric permittivity study shows controlling amount sic nws possible improve multiple properties achieving lightweight material stealth technology elsevier ltd techna group rights reserved
electrospinning process extruding fine fiber charged polymer solution fiber continuously stretched electrostatic forces evaporation solvent traveling air prior deposition fibers provide high surface area volume ratio high porosity useful many engineering areas biomedical materials engineering one major issue process lack functional model link processing parameters polymer solution properties fiber morphology fiber diameter distribution developed models far functional specific polymer solvent system study present application gene expression programming gep model prediction electrospun fiber morphology polymer solution properties poly ethylene oxide peo poly ethylene glycol peg solution characteristics surface tension conductivity viscosity relaxation time fed molecular weight mol elastic modulus extensional stress used predictor variables prediction accuracy compared classification regression trees cart method results show gep model predicts better cart model promising nanofiber morphology prediction
electrosynthesized cadmium indium selenide cdinse thin films photo electrochemically analyzed current voltage characteristics photoresponse speed response electrochemical impedance study capacitance voltage characteristics improved phottdsleve oconversion efficiency electrosynthesized cdinse thin film based photoelectrochemical cell explained help theoretical modeling energy band diagram equivalent circuit model impedance spectra photoelectrochemical cell elsevier rights reserved
elevated levels homocysteinemia hcy risk factor late onset alzheimer disease associated changes cell methylation alzheimer disease characterized upregulation lipoxygenase whose promoter regulated methylation however whether hcy activates enzymatic pathway influencing methylation status promoter remains unknown brains mice high hcy assessed pathway neuronal cells exposed hcy implemented study mechanism regulating expression levels effect amyloid formation diet genetically induced high hcy resulted protein mrna upregulation associated significant increase adenosylhomocysteine sah adenosylmethionine ratio reduced dna methyltrasferases hypomethylation lipoxygenase dna vitro studies confirmed results demonstrated mechanism involved hcy dependent activation amyloid formation dna hypomethylation secondary elevated levels sah taken together findings represent first demonstration hcy directly influences expression levels establish previously unknown cross talk two pathways highly relevant pathogenesis discovery novel link provides new mechanistic insights neurobiology hcy importantly new therapeutic opportunities individuals bearing risk factor disease
elevated vertebral bone marrow fat bmf among individuals osteoporosis established histomorphometric studies several studies found negative correlation bmf bone mineral density bmd spine men women across different age groups animal studies also observed bone loss increased bmf mice induced diabetes study objective test hypothesis association bmf bmd varies diabetic status performed cross sectional study men aged years osteoporotic fractures men study pittsburgh clinical site men spine bmf scans using proton magnetic resonance spectroscopy spine hip bmd scans dual energy ray absorptiometry bmf expressed lipid lipid water ratio men considered diabetic self reported physician diagnosis diabetes diabetes medication fasting glucose men diabetes significantly higher spine bmf spine bmd total hip bmd without differences observed body weight body mass index waist circumference pearson correlation tests showed significant correlation spine bmf age bmd non diabetics significant inverse correlations observed bmf bmd femoral neck total hip among diabetic men conclusion men diabetes higher bmf compared non diabetic men correlation bmf bmd differed diabetes status investigation association diabetes bmf bmd may provide better understanding high fracture rates among individuals diabetes despite higher bmd elsevier inc rights reserved
elevation blood triglycerides primarily triglyceride rich lipoproteins tgrl linked cerebrovascular inflammation vascular dementia alzheimer disease brain microvascular endothelial cells astrocytes two cell components neurovascular unit participate controlling bloodbrain barrier bbb permeability regulating neurovascular unit homeostasis studies showed infusion high physiological concentrations tgrl lipolysis products tgrl lipoprotein lipase activate injure brain endothelial cells transiently increase bbb transfer coefficient permeability surface area volume vivo however little known blood lipids affect astrocyte lipid accumulation inflammation address first demonstrated tgrl lipolysis products increased lipid droplet formation cultured normal human astrocytes evaluated transcriptional pathways activated astrocytes tgrl lipolysis products found upregulated stress inflammatory related genes including activating transcription factor atf macrophage inflammatory protein alpha mip alpha growth differentiation factor gdf prostaglandin endoperoxide synthase cox tgrl lipolysis products also activated jnk cjun atf pathway induced endoplasmic reticulum stress protein ebp homologous protein chop kappa pathway increasing secretion mip alpha gdf thus results demonstrate tgrl lipolysis products increase bbb transfer coefficient induce astrocyte lipid droplet formation activate cell stress pathways induce secretion inflammatory cytokines observations consistent evidence lipid induced neurovascular injury inflammation therefore speculate lipid induced astrocyte injury could play role cognitive decline
elliptic curve cryptography ecc branch public key cryptography widely accepted secure data exchange many resource limited devices paper presents novel hardware cryptographic processor ecc general prime field optimized circuit level introducing new parallel modular multiplication algorithm efficient hardware architecture offers significant improvement previously used techniques subsequently system level optimized exploiting available high degree parallelism using projective coordinates incorporating four parallel multiplier units proposed hardware implemented xilinx virtex virtex field programmable gate arrays bit scalar multiplication completed cycle count virtex virtex field programmable gate array paltforms respectively virtex implementation attains maximum frequency mhz occupies look tables whereas virtex mhz slices results show proposed design offers significant improvement computation time significant reduction cycle count compared reported designs therefore good choice used many ecc based schemes copyright john wiley sons ltd
emerging data epidemiologic microbiome physiology research patients functional bowel disorders fbds provide evidence linkage alterations intestinal microbiota fbds however currently data based association studies causality role microbiota disorders established growing evidence compositional changes increasing recognition association intestinal microbiota gut brain functions relevant pathophysiology clinical symptoms fbds led increased interest manipulating intestinal microbiota treatment disorders
emoticons new visual nonverbal communication cues used digital interaction elders recognize discriminate emotional states emoticons well young people study uses emoticons investigate recognizable emotional differences thirty older thirty younger adults total representative emoticons used stimuli consisting realistic facial expressions abstract facial expressions positive emotions neutral emotions negative emotions four questions including emotional state imitative level preference understanding emoticons applied questionnaire results showed older adults positive response toward perceived emoticons younger adults two age ranges different cognition design appearances realistic abstract emoticons older adults showed less preference toward emoticons younger adults result also denotes older adults analogize realistic faces emoticons
empathy facilitates everyday social interactions often linked literature prosocial behavior robust evidence found positive relationship experiencing empathy behaving prosocially however empathy empathy prosocial behavior relationship particular studied mostly combination negative emotions less research conducted empathy positive emotions link positive empathy displayed prosocial behavior intensively investigated far purpose present article thus twofold first review summarize research evidence empathy positive emotions second propose people motivation maintain experienced positive affect viable mechanism linking positive empathy prosocial behavior
empathy essential ability prosocial behavior previous imaging studies identified number brain regions implicated affective cognitive aspects empathy study investigated neural correlates empathy network perspective using graph theory beta series correlations two independent data sets acquired using paradigm elicited empathic responses socioaffective stimuli one data set used define network nodes modular structure data set used investigate effects emotional versus neutral stimuli network connectivity emotional relative neutral stimuli increased connectivity nodes belonging different networks nodes belonged extended default mode network edmn nodes belonged cognitive control network visual networks within edmn posterior stg tpj regions identified provincial hubs edmn also showed stronger connectivity cognitive control network encompassing lateral pfc regions connector hubs two networks posterior cingulate cortex ventrolateral pfc stresses advantage network approach regions similarly modulated task conditions dissociated distinct networks regions crucial network integration identified
empirical analysis price fluctuations financial markets received extensive attention substantial amount financial market data collected advances data mining techniques price fluctuation trends help investors make informed trading decisions decisions may also affected psychological factors anchoring effect study explores intraday price time series taiwan futures applies diffusion model quantitative methods analyze relationship anchoring effect price fluctuations first passage process results indicate power law scaling anomalous diffusion stock price fluctuations related anchoring effect moreover microscopic price fluctuations switching point first passage process correspond long term price fluctuations taiwan stock market find microscopic trends could provide useful information understanding macroscopic trends stock markets elsevier rights reserved
enamel unique epithelial derived mineralized tissue mammals distinct micro nanostructure nanofibrous apatite crystals building blocks synthesized highly specialized cell ameloblast secretes matrix proteins little homology known amino acid sequence composed primary structure makes competent self assemble control apatite crystal growth nanometer scale end product ameloblast activity marvel structural engineering material optimized provide tooth maximum biting force withstanding millions cycles loads without catastrophic failure also protecting dental pulp bacterial attack review attempts bring context mechanical behavior enamel developmental process amelogenesis structural development since linked tissue function importance controlling calcium phosphate mineralization nanometer scale origins apatite nanofibers development stiffness gradient biological processes responsible synthesis hard fracture resistant dental tissue discussed reference evolution enamel fibrous composite complex tough damage tolerant coating dentin
endocrine disrupting chemicals edcs including mass produced component plastics bisphenol bpa widely prevalent aquatic terrestrial habitats many aquatic species fish amphibians aquatic reptiles mammals exposed daily high concentrations bpa ethinyl estradiol estrogen birth control pills review predominantly focus bpa well described estrogenic edcs first evidence bpa detectable almost bodies water discussed consider bpa affects sexual neural development species effects best characterized across taxa instance chemicals many cases reported cause sex reversal males females even chemicals overtly alter gonadal sex indications several edcs might demasculinize male specific behaviors essential attracting mate chemicals may reduce likelihood males reproduce exposed males reproduce concern passing compromised genetic fitness offspring transmitting potential transgenerational effects sperm epigenome thus consider diverse epigenetic changes might unifying mechanism bpa disrupt several processes across species changes might also serve universal species diagnostic biomarkers bpa edcs exposure lastly evidence estrogenic edcs induced effects aquatic species might translate humans considered elsevier inc rights reserved
endogenous cannabinoids endocannabinoids small molecules biosynthesized membrane glycerophospholipid anandamide aea endogenous intestinal cannabinoid controls appetite energy balance engagement enteric nervous system cannabinoid receptors uncover role aea receptor cannabinoid receptor regulation immune tolerance gut pancreas work demonstrates major immunological role endocannabinoid pungent molecule capsaicin similar effect aea however acts engagement vanilloid receptor trpv causing local production aea acts show engagement cannabinoid vanilloid receptors augments number immune suppressive function regulatory cxcr macrophages express highest levels receptors among gut immune cells additionally trpv mice fewer cxcrhi gut treatment mice also leads differentiation regulatory subset cells cells dependent manner vitro vivo functional demonstration tolerance elicited engagement trpv transferred naive nonobese diabetic nod mice model type diabetes transfer cells oral administration aea nod mice provides protection study unveils role endocannabinoid system maintaining immune homeostasis gut pancreas reveals conversation nervous immune systems using distinct receptors
endogenous progestogens important regulators vertebrate reproduction synthetic progestins components human contraceptive hormone replacement pharmaceuticals progestogens progestins enter environment number sources shown cause profound effects reproductive health various aquatic vertebrates progestins designed bind human progesterone receptors also shown strongly activate androgen receptors fish levonorgestrel lng activates fish androgen receptors induces development male secondary sex characteristics females species although behavior postulated sensitive early indicator exposure certain environmental contaminants research reproductive behavior gestagen exposed fish conducted date goal study examine exposure effects human contraceptive progestin lng reproductive development behavior viviparous eastern mosquitofish gambusia holbrooki internal fertilization requisite characteristic viviparous species enabled androgen driven elongation anal fin male gonopodium phallus study exposed adult mosquitofish ethanol etoh control lng using static replacement exposure design subset males females treatment examined differences anal fin ratio addition paired social interaction trials performed using individual control males control females females treated lng female mosquitofish exposed lng masculinized evidenced elongation anal fin rays feature normal males abnormal females lng caused significant increases anal fin ratios female mosquitofish treatments although differences significant two treatments lng caused significant increases anal fin ratio males exposed effects observed treatment addition reproductive behavior control males paired female mosquitofish exposed lng also altered males spent time exhibiting reproductive behavior decreased attending behavior lower number gonopodial thrusts compared control males paired control female mosquitofish given rapid effects anal fin morphology behavior observed study mosquitofish excellent sentinel species detection exposure lng likely nortestosterone derived contraceptive progestins environment elsevier inc rights reserved
energy consumption vehicle described energy balance relationship energy energy consists energy produced energy consumed internal losses well need overcome inertia resistance motion hybrid vehicles show big potential reduction fuel consumption exhaust gas emissions therefore nothing strange fact hybrid cars often identified step journey sustainable future currently powertrain concept allows synchronization operation ice electric motor redistribution mechanical energy flows help transmission shifts depending mode operation hybrid powertrain hpt different hpt control algorithms applied hybrid vehicle designs however purpose minimize fuel consumption minimize exhaust gas emission iii minimize system price ensure good vehicle control characteristics paper presents novel algorithms suitable real time estimation economic ecological characteristics hybrid high mobility multipurpose wheeled vehicle hmmwv vehicles moving urban extra urban road conditions
energy efficiency carbon reduction new buildings key objectives policies aim decrease electric use nationwide particularly summer electricity usage highest case study developed test energy conservation performance economic feasibility creative intelligent open building mega house mega house focuses making improvements four key areas material electronic green building automation paper focuses applications areas electronic green building economic analysis paper electricity consumption potential energy savings based use energy conservation equipment earth tubes solar chimneys situation simulations field measurements four experimental stages economic calculations according results measurement economic analysis mega house demonstrated optimal energy conservation performance using earth tube fan solar chimney exhaust fans mega house lowered indoor temperature similar degrees summer using earth tube fan instead electric heater increased indoor temperature much degrees terms economic benefits using energy conservation facilities installed mega house reduced electricity expenditures decreased emissions around per year elsevier ltd rights reserved
energy efficiency touted critical component societies response challenges climate change economic development energy security although rich literature exists various impediments energy efficiency insufficient attention given political institutional barriers propose classification obstacles group three broad categories political obstruction conflicting guidelines governance structure lack policy coordination illustrate work three cases energy efficiency measures prevented impeded slowed barriers although welcome increased attention types barriers energy efficiency recent years efforts regard may severely limited attention given barriers political institutional type elsevier ltd rights reserved
energy primary universal measure kinds work human beings nature everything happens world expression energy one forms energy neither created destroyed converted one form another wind energy converted one form another wind energy readily converted mechanical energy turbine blades converted electrical energy connecting turbine electrical generator paper analyze aerofoil cross section blade using ansys show velocity profile blade positioned parallel flow wind another blade tilted certain angle flow wind paper also visualizes use variable geometry blade minimize drag wind flows blade
energy management strategies emss critical improvement fuel economy plug hybrid electric vehicles phevs however conventional emss hardly consider influence uphill terrain fuel economy battery life leaving vehicles insufficient battery power continuous uphill terrains hence study optimal control strategy phev based road grade information proposed target state charge soc estimated based road grade information well predicted driving cycle uphill road obtained gps gis system furthermore trajectory soc preplanned ensure sufficient electricity uphill terrain charge depleting charge sustaining modes genetic algorithm applied optimize parameters control strategy maintain soc battery mode pre charge mode designed charge battery mode reasonable distance uphill terrain finally simulation model powertrain system phev established using matlab simulink platform results show proposed control strategy based road grade information helps successfully achieve better fuel economy longer battery life
energy recovery economic aspects also sustainable use energy necessitated optimal operational equipment inside building synchronous monitoring real time analysis system using integrated monitor control energy recovery presented test vicinity taken approach based analysis energy usage bill pay taylor university malaysia scaled approach test area restricted room design employing new methodology optimize energy usage design system based analysing energy wastage caused human factors utility usage factor system design proposes real time monitoring load also health condition various equipment physical environment condition major source operational inefficiency performing utilities usage control using smart system electricity saving expected
energy use buildings significant contributor greenhouse gas emissions climate change residential sector uses energy united states reason among others important implement sustainable design practices construction previous research shown significant barriers sustainability main consideration choosing structural system improve understanding structural engineers attitudes toward sustainability opinion survey conducted oregon washington quantitative qualitative methods used results highlight lack information major barrier adopting sustainable design practices respondents request standardized current reputable data applicable codes standards results also indicate clients important influence structural engineers results suggest structural engineers expand thinking techniques engineering fits larger context sustainable development results also suggest profession whole needs become assertive advising educating clients sustainability american society civil engineers
engineering common sense study refers students level knowledge elementary engineering application characteristic considered essential facilitating students able move involved topics engineering assessment common sense carried among newly enrolled students mechanical manufacturing engineering programs using marks obtained several questions test results showed students already mastered simple mathematical operations hence common sense significant proportion failed apply based answers three simple questions assessment showed two extremes common sense levels almost distribution one lowest highest although admission grade points cohort students considered high appears problem common sense half students think enter tertiary level engineering studies learning becomes formal room using common sense published elsevier ltd
environmental issues become topical subject recent years numerous recycling resources found living environment fallen leaves wood chips recovered iron powder waste newspaper waste concrete reservoir silt etc utilizable waste materials related regulations stipulate waste blending ratio recycling green building materials higher study three waste materials including wood chips concrete waste newspaper mixed gypsum dissolved thermochromic material made bricks thermal radiation sunlight absorbed bricks change hue experimental modules divided abcd groups mixed allochroic powder different specifications rgb values bricks different temperatures hours measured color analyzer results showed rate change rgb values abcd groups higher day night temperature difference exceeds allochroic bricks applied external walls buildings providing landscape building interior designers another media artistic creation elsevier ltd rights reserved
environmental problems positive slope position goes worse point day day side sensitive chemical processes controlled modern controllers chemical process modelling translated transfer function state space representation system theory utilized purpose create state space presentation chemical equations matrix formation combined alternative carrier signal applied acid molarity create square form system matrix transfer function obtained validate novelty new approach applied weak acid strong base neutralization process obtained simulation results shows algorithm effective performance ways modern control theories opened chemical procesess
epidemiologic studies revealed asian sand dust particles asds affect respiratory immune health represented asthma factors responsible exacerbation asthma remain unclear fungus bjerkandera adusta polycyclic aromatic hydrocarbons benzo pyrene bap identified asds collected atmosphere asd event occurred investigated effects bap related asds respiratory immune systems bone marrow derived antigen presenting cells apcs splenocytes atopic prone nga mice human airway epithelial cells exposed bap presence absence heated asds asds bap presence absence asds increased expression cell surface molecules apcs asds alone slightly activated apcs expressions induced higher induced bap presence absence asds remarkable effects activation splenocytes proinflammatory responses airway epithelial cells results suggest rather bap contributes exacerbation asthma regardless presence absence sand particles particularly activation immune system via apcs copyright john wiley sons ltd
epidemiological evidence indicates high consumption tomatoes tomato based products reduces risk chronic diseases cvd cancer potential benefits often ascribed high concentrations lycopene present tomato products mainly results vitro studies potential biological mechanisms carotenoids could protect heart disease cancer suggested include cholesterol reduction inhibition oxidation processes modulation inflammatory markers enhanced intercellular communication inhibition tumourigenesis induction apoptosis metabolism retinoids antiangiogenic effects however regard cvd results intervention studies gave mixed results fifty human intervention trials lycopene supplements tomato based products conducted date majority underpowered many showed beneficial effects mostly non established cardiovascular risk markers lipid peroxidation dna oxidative damage platelet activation inflammatory markers studies showed improvement lipid profiles reactive protein blood pressure however recent findings indicate lycopene could exert cardiovascular protection lowering hdl associated inflammation well modulating hdl functionality towards antiatherogenic phenotype furthermore vitro studies indicate lycopene could modulate lymphocyte activity would also inhibit atherogenic processes confer cardiovascular protection findings also suggest hdl functionality deserves consideration potential early marker cvd risk modifiable dietary factors lycopene
epidemiological studies showed strong association alcoholism incidence stroke underlying causative mechanisms remain understood found infiltration immune cells deposition cholesterol site brain artery capillary injury induced atherosclerosis chronic alcohol ethanol consumption presence absence high fat diet conversion cholesterol sharp edges cholesterol crystals ccs alcohol intake key activation nlrp inflammasome induction cerebral atherosclerosis development neuropathy around atherosclerotic lesions presence alcohol critical formation ccs development neuropathology thus observed alcohol consumption elevated level plasma cholesterol deposition crystallization cholesterol well activation nlrp inflammasome led arteriole capillary walls thickening increase intracranial blood pressure distinct neuropathy around atherosclerotic lesions indicated vascular inflammation initial cause neuronal degeneration demonstrated molecular mechanisms nlrp activation downstream signaling cascade event primary culture human brain arterial capillary endothelial cells setting dose time dependent effects alcohol ccs using nlrp gene silencing technique also detected ccs blood samples alcohol users validated clinical importance findings finally combined therapy acetyl carnitine lipitor prevented deposition cholesterol formation ccs activation nlrp thickening vessel walls elevation intracranial blood pressure conclude alcohol induced accumulation crystallization cholesterol activates nlrp caspase cerebral vessel leads early development atherosclerosis
epilepsy migraine common diseases nervous system share genetic pathophysiological mechanisms familial hemiplegic migraine autosomal dominant disease often used model migraine four genes often contain one mutations epilepsy hemiplegic migraine patients cacnaa atpa scna prrt better understanding shared genetics epilepsy hemiplegic migraine may reveal new strategic directions research treatment disorders
escherichia coli one frequently isolated gram negative pathogens cases foodborne diseases hospital infections diarrheal diseases including associated pathogenic coli strains leading causes morbidity mortality worldwide especially among children improvements management diarrheal diseases caused bacteria spotlight world health organization therefore still need develop new methods improve ones commonly used characterize distinguish coli strains precisely work trs based pcrs effectively used discrimination coli strains isolated children diarrhea lodz region poland composite trs pcr approach based similarity comparisons gtg pcr cgg pcr fingerprints enabled distinguish strains good efficacy confirmed high diversity index high reproducibility band patterns obtained results showed great variation strains may cause infections children months however stains grouped three separate clusters different terms phylogenetic affiliation virulence factor repertoire obtained results support consistent need public health surveillance searching new fast assays far children health concerned trs pcr profiling effective tool genotyping coli strains isolated children diarrhea
esophageal hypersensitivity important gastroesophageal reflux disease gerd patients refractory acid suppressive therapy stress affects visceral sensitivity exacerbates heartburn gerd peripheral crh key mediator gut stress response hypothesize crh increases esophageal sensitivity alters esophageal motility health esophageal sensitivity thermal mechanical electrical chemical stimuli assessed healthy subjects administration placebo crh perception scores assessed first perception pain perception threshold ppt pain tolerance threshold ptt esophageal motility investigated high resolution impedance manometry crh evaluated distal contractile integral dci intrabolus pressure ibp pressure flow analysis assessed bolus clearance impedance ratio degree pressurization needed propel bolus onward ibp slope pressure flow pressure flow index pfi stress mood assessed study sensitivity mechanical distention increased crh compared placebo ppt ptt crh influence stimulations dci increased boluses liquid semisolid solid impedance ratio liquid semisolid swallows decreased crh ibp slope increased crh semisolid solid swallows pfi increased semisolid solid swallows crh increased esophageal sensitivity mechanical distention stimulation modalities crh increased esophageal contractility tone decreased les relaxation increased esophageal bolus pressurization improved esophageal bolus clearance increased pressure flow new noteworthy first study address effect corticotropin releasing hormone crh esophageal sensitivity alterations motility health crh administration increased esophageal sensitivity mechanical distention effect accompanied increase esophageal contractility tone decrease lower esophageal sphincter relaxation crh increased esophageal bolus pressurization improved esophageal bolus clearance increased pressure flow changes esophageal contractile properties may underlie increased sensitivity mechanical distention crh
especially seniors ambient intelligence provide assistance daily living emergency situations example automatically recognizing critical situations use systems may involve trade offs regard privacy social stigmatization changes well known living environment raises question older adults perceive restrictions privacy accept technology requirements placed ambient intelligent systems order better understand related concerns expectations surveyed senior citizens results show experience ambient intelligence increases technology acceptance reduces fears regarding privacy violations insufficient system reliability participants generally tolerate monitoring activities home including bathrooms accept commercial service providers data recipients comparison four exemplary systems shows camera based solutions perceived much greater fears wearable emergency solutions burglary detection rated similarly important assigned health features whereas living comfort features considered less useful
essential oils eos leaves one patchouli oil yielding wild species pogostemon plectranthoides collected three bio geographical regions india namely western ghats central india northeast india nei characterized using fid chemical analyses showed eos rich sesquiterpenes exhibited wide variation chemical compositions total volatile components oils identified eight present oils three regions tyrosinase inhibitory anti inflammatory activities eos studied using vitro assays showed three oils exhibited activities however degree activities varied studies kinetic behavior eos showed oils mixed type inhibitors whereas oil nei competitive inhibitor among eos studied oil nei demonstrated high activities may used cosmetics skin care products exhibited tyrosinase inhibitory anti inflammatory activities elsevier rights reserved
essure hysteroscopic sterilization food drug administration approved united states since complications associated essure device include improper placement malpositioning unintended pregnancy pain infection nickel allergy rarity complications compounded underreporting makes difficult determine best practices insofar management systematic review synthesizes national global experience management essure related complications suggests treatment options data allow aagl rights reserved
estimating transformations degraded point sets necessary many computer vision pattern recognition applications paper propose robust non rigid point set registration method based spatially constrained context aware gaussian fields first construct context aware representation shape context assignment initialization use graph laplacian regularized gaussian fields estimate underlying transformation likely correspondences one hand intrinsic manifold considered used preserve geometrical structure priori knowledge point set extracted hand using deterministic annealing presented method extended projected high dimensional feature space reproducing kernel hilbert space kernel trick solve transformation local structure propagated coarse fine scaling strategy way proposed method gradually recovers much correct correspondences estimates transformation parameters accurately robustly facing degradations experimental results synthetic real data point sets demonstrate proposed method reaches better performance state art algorithms
estimation optimal controller fundamental problem control engineering widely known optimization numerous computation numerical techniques evolved past years estimation optimal solution optimal control discrete time system concerned optimizing given objective function using homogenous polynomial lyapunov function hplf research focuses upon design optimal guaranteed cost controller gcc discrete time uncertain system using hplf uncertainties assumed norm bounded uncertainties effect actuator saturation also incorporated system sufficient conditions existence hplf derived terms linear matrix inequalities lmi lmi approach advantage solved efficiently using convex optimization lmi combined hplf helps design guaranteed cost controller minimizes cost minimizing cost function furthermore state trajectories invariant set also shown observation overall performance sharif university technology rights reserved
estimation draft requirement tillage implements important machine design tractor selection viewpoints study model developed calculate draft force power disk plow model effects soil cutting soil displacement soil metal friction processes specific draft force disk plow considered model inputs consisted soil parameters plow parameters working condition parameters simplify required calculations derived equations entered excel software finalized spreadsheet utilized disk plow draft force power calculator one advantages developed model required calculations depend upon dimensionless factors model verification carried comparing model outputs corresponding results studies moreover output model measured draft force plowing silty clay loam soil compared according results study form equation developed paper hendrick formula regarding specific draft force compatible since equations polynomials order respect forward velocity plow hand developed model overestimated required draft force disk blade comparison godwin model however average value overestimation moreover draft force power requirements three blade disk plow working silty clay loam soil forward velocity respectively lower results obtained developed model therefore developed model used calculate disk plow draft force power reasonable accuracy elsevier rights reserved
estradiol supplementation shown enhance cognitive performance old ovariectomized rhesus macaques macaca mulatta determine similar benefits could achieved perimenopausal animals using alternative hormonal supplements administered dehydroepiandrosterone dhea old ovary intact female rhesus macaques similar months using computerized touch screen memory tasks including delayed response delayed matching sample dms observed improved performance time animals failed detect significant effect dhea hand gene expression profiling disclosed significant correlation cognitive performance expression several steroidogenic steroid responsive genes performance positively correlated hippocampal expression akrc star negatively correlated expression sdrda positive correlation also found dms performance prefrontal cortical expression akrc negative correlation star well negative correlation hippocampal expression hsdb nrc taken together results suggest steroidogenic gene regulation within brain may help maintain cognitive function perimenopausal transition period despite decline sex steroid levels circulation
ethnopharmacological relevance saraca asoca roxb wilde ashok popular traditional plant used gynecological disorders india juice ashok flowers traditionally consumed tonic women case uterine disorders despite use estrogenic potency yet evaluated thus lacks scientific recognition acclaim aim study study designed investigate estrogenic potential standardized ethanolic extract saraca asoca flowers saf using ovariectomized ovx female albino wistar rat model materials methods saraca asoca flowers extracted ethanol using hot maceration technique extract standardized terms content four phytoestrogens like quercetin kaempferol beta sitosterol luteolin using hptlc technique safety extract evaluated dose body weight female albino wistar rats per oecd guidelines bilateral ovariectomy surgery performed excision ovaries ovx animals treated ethanolic extract saf three dose levels body weight distilled water vehicle orally day two weeks estradiol valerate employed modern drug comparative evaluation results estrogenic potency studied assaying activities serum plasma marker enzymes hormones viz gpdh ldh beta estradiol progesterone along cholesterol triglycerides hdl vaginal cornification uterotrophic effect evaluated studying histoarchitecture uterus effect uterine weight changes levels uterine glycogen content results hptlc revealed presence markers like quercetin kaempferol beta sitosterol luteolin ethanolic extract saf content four markers found respectively saf extract found safe oral dose body weight rats among three doses administered ovariectomized rats treatment high dose found efficacious compared ovariectomized rats conclusion findings study firmly support estrogenic potency ethanolic extract saf may reason phytoestrogens
ethnopharmacological relevance traditional medicine used uvaria rufa blume ethnomedicinal plant treating fever skin allergies intestinal ulcers prostate disorders including bph however scientific evidence supports traditional use aim study study aimed evaluate therapeutic potential rufa bph using vitro vivo models materials methods vitro studies screened efficacy alpha reductase alpha inhibition antioxidant activity petroleum ether ethyl acetate ethanol aqueous extracts stem rufa phytochemical screening performed determine active compound using high performance liquid chromatography hplc ethyl acetate extract etoac rufa used evaluate therapeutic efficacy vivo models bph induced subcutaneous injection testosterone propionate male rats days days oral administration etoac doses finasteride dose prostate weight prostate index testosterone androgen receptor levels histopathological alteration prostate gland determined also oxidative status toxicity indices assessed results etoac exhibited highest potency inhibition alpha possessed potent antioxidants rich phenolics flavonoids contents active compound analyzed hplc beta sitosterol vivo results show significant reduction prostate weight treated groups compared bph model group also etoac finasteride treated groups increased prostatic serum testosterone levels compared bph model group histopathological investigation prostate glands supported results etoac elevated antioxidant enzymes reduced malondialdehyde level bph induced rats moreover treatment etoac doses toxic effects vital organs serum biochemical indices conclusions etoac stem uvaria rufa blume appears potential phytotherapeutic agent management bph provides scientific evidence traditional use
evaa autophagy related protein plays important role embryonic neurogenesis study found loss evaa could decrease neural differentiation brain adult evaa mice determine mechanism underlying phenotype performed label free quantitative proteomics bioinformatics analysis using brains evaa wild type mice identified proteins regulated regulated brains knockout mice compared wild type counterparts bioinformatics analysis indicated biological processes including atp synthesis oxidative phosphorylation tca cycle involved evaa regulatory network addition gene set enrichment analysis showed neurodegenerative diseases alzheimer disease huntington disease strongly associated evaa knockout western blot experiments showed changes expression nicotinamide nucleotide transhydrogenase important mitochondrial enzyme involved tca cycle brains evaa knockout mice study provides valuable information molecular functions regulatory network evaa gene well new perspectives relationship autography related proteins neural differentiation
evacuation simulation potential used part decision support system large scale incidents provide advice incident commanders viable applications essential simulation run many times faster real time parallel processing method reducing run times large computational simulations distributing workload amongst number processors paper presents development parallel version rule based evacuation simulation software buildingexodus using domain decomposition four case studies tested using cluster consisting intel core duo dual core ghz cpus involved idealised large geometry exits intended illustrate peak computational speed performance parallel implementation population consisted agents peak computational speedup pcs peak real time speedup prts long area single exit area population agents pcs prts storey high rise building population agents pcs prts large realistic urban area agents pcs prts type computational performance opens evacuation simulation range new innovative application areas real time incident support dynamic signage smart buildings virtual training environments
evapotranspiration one important components hydrological cycle often difficult variable determine basin scale traditionally estimated using pointbased measurements collected meteorological stations non spatial nature measurements often leads significant errors utilized watershed scale study metric mapping evapotranspiration high resolution internalized calibration approach evaluated using remotely sensed observations moderate resolution imaging spectroradiometer sensor data meteorological stations lower catchment buyuk menderes basin western turkey form actual maps daily monthly intervals april september energy fluxes daily maps resulting metric compared data estimated help meteorological parameters results found compatible ground based estimations suggest considerable potential metric model estimating spatially distributed actual values little ground based weather data
even though researchers paid great deal attention wetland loss status actual extent wetland loss global scale especially loss caused directly human activities actual extent currently surviving wetlands remains uncertain paper simulated potential distribution global wetlands employing new precipitation topographic wetness index ptwi global remote sensing training samples results show earth would approximately million wetlands humans interfere wetland ecosystems combining datasets related global wetlands found least global wetlands beett lost including million non water wetlands million open water areal extent wetland loss greatest asia europe experienced serious losses wetland related datasets suffer major inconsistencies estimates areal extent remaining global wetlands ranged million therefore although challenging thematic mapping global wetlands necessary urgently needed elsevier rights reserved
event history studies based disease clinic data often face several complications specifically patients may visit clinic irregularly intermittent observation times could depend disease related variables cause failure time outcome dependently interval censored propose weighted estimating function approach dependently interval censored failure times analysed consistently called inverse intensity visit weight employed adjust informative inspection times left truncation failure times also easily handled additionally observational studies treatment assignments typically non randomized may depend disease related variables inverse probability treatment weight applied estimating functions adjust measured confounders simulation studies conducted examine finite sample performances proposed estimators finally toronto psoriatic arthritis cohort study used illustration copyright john wiley sons ltd
events temporal figures defined identifiable segments time bounded beginnings endings functions importance two boundaries differ argue beginnings loom larger endings attracting attention judged important interesting warranting explanation causal power difference follows lay notion additions introduction something new imply change demand effort subtractions returning previous state affairs beginning advantage demonstrated eight studies people representations epochs events historical timeline well cyclical change annual seasons people think important know wars reigns started ended interested reading beginnings endings historical movements transitional events elections passages one season next claim interest grow importance framed beginnings follows conclusions came beginnings often identified retrospect beginning advantage may distort exaggerate actual historical importance elsevier rights reserved
every day primarily experience actions agents concrete perspective actions means goals peculiar perspective allows successfully plan execute actions dense social environment nevertheless environment actions also perceived observer perspective adopting perspective helps understand respond people actions outcomes importantly similar experiences agent observer occur also actions physically acted perceived merely linguistically shared paper present two exploratory studies one italian one german applied direct comparison three singular perspectives combination different verb categories first second third person pronouns combined action interaction verbs verbs implying interaction object grasp interaction object another person give means kinematics recording analyzed participants reaching grasping responses mouse presented different combinations linguistic stimuli pronouns verb type results experiment reaching show preceded interaction verbs reached velocity peak earlier action verbs since motor act follow thus pronouns influence perspective taking comprehending language sensitive motor chain organization verbs absence effects experiment likely due fact pronoun german mandatory perceived less salient italian overall result supports idea language grounded motor system flexible way highlights need cross linguistic studies field embodied language processing
evidence clinical experimental data suggests thyrotropin receptor tshr signaling involved energy expenditure impact white adipose tissue wat brown adipose tissue bat tshr expression increases mesenchymal stem cell msc differentiation fat hypothesize tshr activation tshr elevated thyroid stimulating hormone thyroid stimulating antibodies tsab activating mutation influences msc differentiation contributes body composition changes seen hypothyroidism graves disease role tshr activation adipogenesis first investigated using vivo samples neck fat euthyroid surgery obtained tsab positive toxic multinodular goiter tmng tsab negative control patients benign euthyroid disease tsab negative effect tshr activation analyzed using human primary abdominal subcutaneous preadipocytes cells cultured complete medium adipogenic medium adm containing thiazolidinedione tzd ppar agonist able induce bat formation without tshr activation gain function mutant weeks adipogenesis evaluated using oil red oro counting adipogenic foci qpcr measurement terminal differentiation marker lpl bat pgc alpha uncoupling protein ucp zic pre bat prdm brite cited wat leptin markers analyzed semiquantitative pcr qpcr vivo analysis differences expression ucp pgc zic brite marker cited levels highest followed tmng control trend associated higher wat marker leptin level two groups primary cell culture tshr activation substantially enhanced adipogenesis oro foci lpl fold increases compared controls surprisingly tshr activation also significantly increased pre bat marker prdm furthermore tzd adm induced adipogenesis showed substantially increased bat markers pgc ucp study revealed tshr activation plays important role adipogenesis process brite pre bat formation leads wat bat phenotype may contribute weight loss heat hyperthyroidism later transforms wat posttreatment patients gain excess weight
evidence steadily accumulating support neurodevelopmental basis pedophilia includes increased incidence non right handedness result primarily prenatal neural development solidified early life minor physical anomalies mpas superficial deviations typical morphological development detached earlobes also develop prenatally suggesting another potential marker atypical physiological development prenatal period among pedophiles study administered waldrop physical anomaly scale assess prevalence mpas clinical sample men referred assessment following sexual assault another illegal clinically significant sexual behavior significant associations emerged mpa indices indicators pedophilia including penile responses depictions children number child victims possession child pornography moreover greater sexual attraction children associated elevated craniofacial peripheral anomalies ratio overall sample demonstrated greater number mpas relative prior samples individuals schizophrenia well healthy controls
evidence high increasing incidence childhood onset bipolar disorder united states viewed skeptically review evidence childhood onsets bipolar disorder common europe treatment delays longer illness course adverse difficult epidemiological data studies offspring high risk also support findings cohort outpatients bipolar disorder two major vulnerability factors early onset genetics environmental adversity childhood also greater europe increased familial loading multiple psychiatric disorders apparent generations family members patients familial burden linked early onset bipolar disorder since early onset treatment delay risk factors poor outcome adulthood new clinical research public health initiatives needed begin address ameliorate ongoing potentially devastating clinical situation authors published elsevier ltd open access article license http creativecommons orgilicensesiby
evidence shows increased risk psychological distress mental health problems refugee populations despite refugees often display ability continue function recover live meaningful productive lives parents mental health coping style significant mental health wellbeing children aim study explore coping mechanisms utilised displaced syrian refugees care children twenty seven mothers two professional aid workers refugee camps humanitarian contexts turkey syria participated interviews focus groups data analysed using thematic analysis data structured three themes adaptation new norm acceptance normalisation gratitude reaching support aiding problem solving gaining support keeping mentally strong using faith soothe pain motivate parent well number themes associated syrian refugee coping pre resettlement identified themes may translated strategies improve culturally appropriate psychosocial interventions settings
evidence suggests idiopathic parkinson disease consequence neurodevelopmental disruption rather strictly consequence aging thus hypothesized maternal supplement omega polyunsaturated fatty acids omega pufa may associated neuroprotection mechanisms self sustaining cycle neuroinflammation neurodegeneration lipopolysaccharide lps model test hypothesis behavioral neurochemical assay performed prenatally lps exposed offspring postnatal day determine whether prenatal lps exposure maternal omega pufas supplementation persisting effects brain injury induced rats following bilateral intranigral lps injection pre postnatal inflammation damage affected dopaminergic neurons directly also modified critical features activated microglia astrocyte cells disrupting support provided microenvironment unexpectedly results failed show involvement caspase dependent independent apoptosis pathway neuronal death mechanisms hand learning memory deficits detected second toxic exposure significantly attenuated maternal omega pufas supplementation group addition omega pufas promote beneficial effect synaptic function maintaining neurochemical integrity remaining neurons without necessarily protect neuronal death thus results suggest omega pufas affect functional ability central nervous system complex way multiple inflammation induced neurotoxicity animal model disclose new ways understanding fatty acids control responses brain different challenges
evidence based treatment manualized psychotherapy recent rich history interest research progressed defining role treatment manuals resident training clinical practice become important although universal definition treatment manual clinicians researchers agree treatment manuals essential piece evidence based therapy despite several limitations offer advantages training residents psychotherapy requirements resident training psychotherapy changed years treatment manuals offer simple straightforward way meet training requirements search limited depression two treatment manuals emerged support research regarding clinical practice resident training looking toward future important clinicians remain updated advances evidence based manualized treatment tool training residents psychotherapy including recent developments online smartphone based treatments
evolution low energy nuclear physics publications last years analyzed using nuclear physics databases extensive study nuclear science references experimental nuclear reaction data exfor evaluated nuclear structure data file ensdf contents provides unique picture refereed non refereed nuclear physics references significant fractional contributions non refereed reports private communications conference proceedings exfor ensdf databases reflect extensive experimental campaigns insufficient number research journals trend reversed recent years number measurements much lower number journals higher addition nuclear physics results mainly published limited number journals physical review nuclear physics present work historic publication trends averages extracted analyzed using nuclear data mining techniques results study implications discussed conclusions presented
evolutionary algorithms one popular forms optimization algorithms comparatively easy use successfully employed wide variety practical applications however frequently necessary execute parallel order reduce runtime number different approaches parallelization evolutionary algorithms various hardware platforms used parallel execution however every platform equally suitable kind parallelization evolutionary algorithms addition also depends properties concrete optimization problem solved used evolutionary algorithm platform best suited execution present work observes detail two common forms parallelization evolutionary algorithms island model global parallelization four widely used parallel computing platforms multi core cpus clusters graphics cards grids based empirical analytical investigations determined circumstances architecture better suited execution parallel evolutionary algorithm another vice versa guidelines derived support users parallel evolutionary algorithms choice appropriate platform copyright john wiley sons ltd
excess proinflammatory cytokines owing activation kappa nlrp inflammasome play key role inflammatory bowel disease ibd previously reported anti inflammatory activity carboxyamidotriazole cai resulting decreasing cytoldnes therefore investigated therapeutic effects cai trinitrobenzene sulfonic acid tnbs induced rat colitis involvement cai action nlrp inflammasome kappa pathway cai orally administered tnbs induced colitis rat severity colitis assessed nlrp inflammasome kappa pathway cytokines determined results showed cai significantly reduced weight loss disease activity index dai scores colitis rats alleviated colonic macroscopic signs pathological damage addition intestinal inflammatory markers permeability index markedly ameliorated cai treatment decreased levels tumor necrosis factor alpha tnf alpha interleuldn beta also detected colon tissues cai treated colitis rats moreover activation nlrp inflammasome inflamed colon significantly suppressed showing obvious reduction nlrp activated caspase levels furthermore cai reduced expression kappa alpha phosphorylation degradation colitis rats therefore cai attenuates tnbs induced colitis may attributed inhibition nlrp inflammasome kappa activation regulation proinflammatory cytokines results provide understanding intestinal anti inflammatory effect cai highlight potential drug treatment ibd elsevier rights reserved
excessive beta deposition brain associated formation senile plaques diffuse distribution related alzheimer disease thirty rats irradiated light emitting diode photobiomodulation pbm frontal region skull inoculated beta toxin hippocampus rats used control group analysis conducted days irradiation observed decreased beta deposits treated animals compared animals behavioral motor assessment revealed group covered larger ground distance explored open field group days group statistically significant spatial memory test compared group day use pbm significantly reduced presence beta plaques improved spatial memory behavioral motor skills treated animals day
excessive internet use adolescents young people related intrapersonal interpersonal difficulties aim research study relationship problematic internet use psychological well responses social anxiety obsessive compulsive participants male female high school college students aged years results indicate age influences factors compulsive internet use gender affects levels problematic internet use males scoring higher compulsive internet use negative outcomes significant direct correlation found problematic internet use responses social anxiety obsessive compulsive main predictors problematic internet use environmental mastery social anxiety obsessive compulsive symptoms concluded tentatively young people social anxiety could find internet use means pleasant interaction young people obsessive compulsive symptoms could become excessive internet users means eliminate compulsive anxiety
excessive plastic waste river water pollution never ending environmental problems faced every country around world paper polymeric membrane synthesized plastic waste high density polyethylene hdpe type treat contaminated river water plastic waste grinded powder different particle sizes synthesizing membrane sintering method membranes synthesized without addition solvents heating temperature membrane synthesis also study membrane performance terms percentage permeate rejection permeate flux hdpe membrane produced average particle size achieved highest permeate rejection highest heating temperature degrees field emission scanning electron microscopic fesem analysis showed sintered membranes exhibit porous asymmetric structure meanwhile fourier transform infrared spectroscopy ftir analysis denote hdpe membranes grouped alkanes aromatics compounds penerbit utm press rights reserved
excessive sedimentation derived anthropogenic activities main factor habitat biodiversity loss freshwater ecosystems prevent offsite movement soil particles many environmental regulatory agencies mandate use perimeter silt fences however research regarding efficiency devices applied settings lacking fences often ineffective due poor installation maintenance provide overview current state research regarding silt fences address current culture surrounding silt fence installation maintenance provide several recommendations improving knowledge base related silt fence effectiveness clear need integrated long term extending prior fence installation well fence removal multi disciplinary research appropriate controls evaluates effectiveness silt control fences laboratory experiments silica modelling field studies many factors experimentally manipulated soil types sediment feed rate precipitation regimes flow rate season slope level site disturbance fence installation method type fence material depth toe type spacing support structures time since installation level inspection maintenance among others require systematic evaluation inform practice well identify specific technical research needs related silt fence design use moreover constitutes proper installation maintenance unclear especially given regional site level variation precipitation slope soil characteristics educating empowering construction crews proactive maintenance silt fencing needed given apparent lack compliance monitoring regulatory agencies realities damage almost instantaneous silt fences fail goal dismiss silt fences potentially useful tool instead question way currently used call better science determine factors terms fence design installation site characteristics influence effectiveness well better training install maintain inspect devices also encourage efforts look beyond fence consider silt fences combined sediment control strategies part integrated sediment control program elsevier ltd rights reserved
excitation contraction coupling cardiac myocytes requires calcium influx type calcium channels sarcolemma gates calcium release sarcoplasmic reticulum ryanodine receptors process known calcium induced calcium release producing myoplasmic calcium transient enabling cardiomyocyte contraction spatio temporal dynamics calcium release buffering reuptake sarcoplasmic reticulum play central role excitation contraction coupling normal diseased cardiac myocytes however quantitative understanding cells calcium machinery study mechanisms underlie normal cardiac function calcium dependent etiologies heart disease requires accurate knowledge cardiac ultrastructure protein distribution subcellular function current imaging techniques limited spatial resolution limiting insight changes calcium handling computational models excitation contraction coupling increasingly employed probe structure function relationships review focus development structural models cardiac calcium dynamics subcellular level orienting reader broadly towards development models subcellular calcium handling cardiomyocytes specific focus given progress recent years terms multi scale modeling employing resolved spatial models subcellular calcium machinery review state art followed review emergent insights calcium dependent etiologies heart disease finally offer perspective future directions related computational modeling simulation efforts
existing automated compliance checking acc efforts limited automation reasoning capabilities state art acc still uses hoc reasoning schema methods lack support complete automation acc reasoning first order logic fol representation reasoning provide generalized reasoning method facilitate complete automation acc reasoning paper presents new fol based information representation compliance reasoning irep schema representing reasoning regulatory information design information checking regulatory compliance building designs schema formalizes representation regulatory information design information form semantic based ontology based logic clauses could directly used automated compliance reasoning two alternative subschemas following closed world assumption open world assumption noncompliance detection respectively proposed tested proposed irep schema tested representing reasoning quantitative regulatory requirements chapter international building code design information two story duplex apartment test case two ways using perfect information imperfect information closed world assumption subschema selected based performance results achieved recall precision noncompliance detection using perfect information recall precision noncompliance detection using imperfect information american society civil engineers
expectations others reciprocate benefits received play crucial role establishment stable reciprocal exchange within social relationships current study year old preschool children allocated first phase resources one recipient another recipient subsequently possibility ask one valuable resources results experiment show preschool children expect others reciprocate strategically ask ones benefitted share experiment demonstrates selective resource request recipients absent children resource allocations experiment showed children focused absolute amount resources given recipients monitor relative generosity judging recipients nicer study provides first evidence preschool children possess reciprocity expectations point thus strategic nature early social behavior
experimental observations plasma dielectric material interaction reported planar sheet shaped dielectric barrier discharge plasma produced atmospheric pressure helium gas epoxy resin dielectric covered stripe electrodes energized high voltage source khz frequency observed discharge remain stable uniform parametric range discharge process dielectric erosion observed form powder formation dielectric insulation sem analysis reveals powder contains individual well cluster particles size micron may possible produce sub micron particles dielectrics using dbd plasma small particles may find significant applications materials engineering biomedicine
experimental self driving cars tested public roads point commercially sold made otherwise available public self driving car digital control systems take control tasks previously performed human driver places high demands control system perform highly complex task driving car traffic system perform task adequately damage ensues failure control system may used stepping stone claim liability manufacturer car control system uncertainties application product liability law may slow uptake self driving cars warranted basis technical progress article examines decision timing market introduction approached possible chilling effects liability law redressed adequate system obligatory insurance maurice schellekens published elsevier ltd rights reserved
experiments computer teaching process often need use number operating systems often destroys computer room common operating system maintenance engine room brought difficulties traditional experiments build virtual experimental platform complete basis virtual machine technology improve use engine room also release administrator tedious maintenance work therefore important practical value
exploration search space optimisation phenotypic diversity increasing interest within field evolutionary robotics novelty search recent map elites two state art evolutionary algorithms diversify low dimensional phenotypic traits divergent exploration paper introduce novel alternative rapid divergent search feature space unlike previous phenotypic search procedures proposed spatial hierarchical illuminated neuro evolution shine algorithm utilises tree structure maintenance selection potential candidates shine penalises previous solutions crowded areas landscape experimental results show shine significantly outperforms novelty search map elites performance exploration conclude shine algorithm viable method rapid divergent search low dimensional phenotypic landscapes
exploring visible light responsive media remains challenge solar energy photocatalysis applications report nis reduced graphene oxide hybrid composites sheet sheet structures synthesized facile microwave assisted method morphology structure photocatalytic activity reduction characterized scanning electron microscopy ray diffraction vis absorption spectroscopy electrochemical impedance spectra respectively results show hybrid composites show excellent visible light photocatalytic activity reduction compared pure nis reduction rate higher achieved reduced graphene oxide visible light irradiation min improvement attributed efficient charge separation active sites due integrative effect good interfacial contact nis reduced graphene oxide elsevier inc rights reserved
exposure children domestic violence abuse dva form child maltreatment short long term behavioural mental health impact health care professionals generally uncertain respond domestic violence particularly unclear best practice regards children exposure role multiagency response systematic review report educational structural whole system interventions aim improve professionals understanding response dva survivors children searched bibliographic databases contacted topic experts studies reporting quantitative outcomes type intervention aiming improve professional responses disclosure dva child involvement included interventions physicians nurses socialworkers teachers twenty one studiesmet inclusion criteria three randomised controlled trials rcts pre post intervention surveys training three system level interventions training interventions generally positive effects participants knowledge attitudes towards dva clinical competence results rcts consistent surveys results system level interventions aimed change organisational practice inter organisational collaboration demonstrates benefit coordinating system change child welfare agencies primary health care organisations implications policy research discussed authors child abuse review published john wiley sons ltd
exposure media violence including violent video gaming cognitive desensitization effect lowering empathic concern others need since emerging adulthood offers increased opportunities volunteer strengthen relationships initiate new relationships decreases empathic concern prosocial behavior may prove inhibitive optimal development time reasons current study investigated associations violent video gaming empathic responding prosocial behavior enacted toward strangers friends family members participants consisted emerging adults age range female caucasian four universities united states results showed small moderate effects playing violent video gaming lowered empathic concern males females addition lowered empathic concern partially mediated pathways violent video gaming prosocial behavior toward three targets level trend females strongly associated lower prosocial behavior toward strangers discussion highlights violent video gaming associated lower levels prosocial behavior mechanism decreased empathic concern association affect prosocial behavior differently across target finally implications might development emerging adulthood
extensible markup language xml gaining popularity used widely internet storing exchanging data large xml files transferred network create bottleneck also degrade query performance therefore efficient mechanisms compression decompression applied xml files paper algorithm performing xml compression decompression suggested suggested approach reads xml file removes tags divides xml file different parts compresses different part separate core achieving efficiency compare performance results proposed algorithm parallel compression decompression xml files using gzip performance results show suggested algorithm performs better parallel gzip compression decompression intel xeon intel core intel core based architectures respectively
extracting powerful image features plays important role computer vision systems many methods previously proposed extract image features various computer vision applications scale invariant feature transform sift speed robust feature surf local binary patterns lbp histogram oriented gradients hog weighted hog recently convolutional neural network cnn method image feature extraction classification computer vision used various applications research propose new gender recognition method recognizing males females observation scenes surveillance systems based feature extraction visible light thermal camera videos cnn experimental results confirm superiority proposed method state art recognition methods gender recognition problem using human body images
extranodal natural killer cell lymphoma nasal type enkl rare subtype non hodgkin lymphoma treatment outcome previously poor novel treatment strategies improved outcomes enkl remarkably last decade nowadays patients localized nasal enkl recommended treatment concurrent chemoradiotherapy year overall survival rate approximately patients advanced relapsed refractory disease efficacy asparaginase containing therapy confirmed however still remain unmet needs treatment enkl continued efforts made improvements treatment enkl
extremely large complex projects numerous geographically distributed stakeholders experience substantial risks related interfaces among stakeholders particularly true project definition design despite discrete deliverables across interfaces decisions require iteration managing interfaces become feasible advent internet electronic product process management systems extent full time interface management positions exist practice however lacks formal structure integration critical path method scheduling methods identify high risk interface points ips throughout paper graph based algorithm developed identify key ips network ips capital project furthermore new approach discussed link key ips interface milestones identify schedule related risks mitigate adverse impact functionality proposed algorithms demonstrated offshore model project contributions paper provide foundational material research american society civil engineers
fluorodeoxyglucose positron emission tomopraphy computed tomography fdgpet proven useful imaging many types cancer however role well defined hepatocellular carcinoma hcc assessed prognostic value metabolic imaging biomarkers established baseline pretreatment fdg pet patients hcc retrospectively analyzed records patients hcc underwent fdg pet initial treatment may may four pet parameters measured maximum standardized uptake value suvmax total lesion glycolysis tlg metabolic tumor volume mtv tumor normal liver suv ratio tnr optimal cut values pet parameters stratify patients terms overall survival determined multivariate analysis performed determine whether pet parameters could add prognostic value cancer liver italian program clip scoring system barcelona clinic liver cancer bclc staging system analysis included patients univariate analysis association continuous variables including pet parameters suvmax tlg tumor size total bilirubin level alkaline phosphatase level significant predictors suvmax tlg mtv tnr identified cut values multivariate analysis revealed suvmax tnr independent factors predicting poor prognosis clip scoring system bclc staging system tlg bclc staging system pretreatment fdg pet patients hcc add prognostic value standard clinical measures incorporation imaging biomarkers derived fdg pet hcc staging systems considered
face recognition becoming common among section study computer vision also one effective programs comprehension image analysis may employed confirmation moment lots means front watch face recognition nicely one instant picture per course obtained nevertheless handful perhaps work paper discuss different face recognition techniques find better method pose variation non uniform motion blur illumination using reference face graph face recognition one example image problem two generalized eigenface algorithms proposed face recognition analyzed thoroughly nevertheless real world face recognition stays job difficult interest unconstrained useful face recognition increasing using surge online media example video surveillance video internet sites wherever encounter evaluation substantial significance face recognition approached within data theory framework identify unfamiliar encounter utilizing exterior reference face graph rfg rfg produced evaluating towards encounters within built rfg acknowledgement given encounter attained centrality steps used recognize encounters unique within reference face graph
facial expressions constitute rich source non verbal cues face face communication provide interlocutors resources express interpret verbal messages may affect cognitive emotional processing contrarily computer mediated communication cmc particularly text based communication limited use symbols convey message facial expressions transmitted naturally scenario people use emoticons paralinguistic cues convey emotional meaning research shown emoticons contribute greater social presence result enrichment text based communication channels additionally emoticons constitute valuable resource language comprehension providing expressivity text messages latter findings supported studies neuroscience showing particular brain regions involved emotional processing also activated people exposed emoticons reach integrated understanding influence emoticons human communication socio cognitive neural levels review literature emoticons three different areas first present relevant literature emoticons cmc second study influence emoticons language comprehension finally show incipient research neuroscience topic mini review reveals plenty studies influence emoticons communication social psychology perspective little known neurocognitive basis effects emoticons communication dynamics
facility based antiretroviral therapy art provision stable patients hiv congests health services resource limited countries assessed outcomes risk factors attrition decentralization community based art refill centers among patients hiv kinshasa democratic republic congo using multilevel poisson regression model death loss followup transfer respectively months overall attrition person years patients years art cluster differentiation type count body mass index receiving nevirapine stavudine showed reduced attrition art refill centers promising task shifting model low prevalence urban settings high levels stigma poor art coverage
facing plethora network security events network security risk evaluation effective method prevent respond security problems ignoring possible changes maybe occurred traditional network security risk evaluation emphasizes preventive management advance article presents approach explore probability network attributes breached accurately bayesian attack graph particular approach extends bag observation node used imply adjustment compromising probability timely dynamically
false working memories readily emerge using visual item recognition variant converging associates task two experiments manipulating study test modality extended prior working memory results demonstrating reliable false recognition effect false alarms associatively related lures unrelated lures within seconds encoding either visual auditory modality however false memories nearly twice frequent study lists seen heard regardless test modality although study test modality mismatch generally disadvantageous consistent encoding specificity final experiment varied study test modality using hybrid short long term memory test flegal atkins reuter lorenz replicated auditory advantage short term revealed reversal long term false memory effect greater auditory study test condition visual study test condition thus encoding conditions gave rise opposite modality advantage depending whether recognition tested short term long term memory conditions although demonstrating continuity associative processing across delay results indicate delay condition affects availability modality dependent features memory trace thus distinctiveness leading dissociable patterns short long term memory performance
families living mental illness express needs support experiences burden may affect health detrimentally hence also ability support patient mindfulness based interventions shown beneficial health effects clinical healthy populations aim current study explore effectiveness usability web based mindfulness program families living mental illness first tested feasibility study study designed randomized controlled trial experiment group wait list control group assessments primary secondary outcomes baseline post intervention month follow significant positive improvements mindfulness self compassion significant decreases perceived stress certain dimensions caregiver burden found good program usability easily accessible mindfulness based interventions may useful addressing caregivers needs support preventing ill health caregivers studies needed among others customize interventions investigate cost effectiveness programs
family structure risk child maltreatment long viewed static state child maltreatment literature drawing data fragile families child wellbeing study author uses series individual fixed effects models investigate whether particular types relationship transitions children first decade life associated increased risk maternal paternal child abuse maternal neglect findings question confirm number long standing theoretical empirical findings child maltreatment literature results indicate transitions single associated increased risk maternal child abuse neglect addition frequency severity paternal harsh parenting may closely linked nature fathers relationship transitions last results largely provide support theory presence social nonbiological fathers increases mothers risk engaging child abuse neglect
fanconi anemia characterized congenital malformations progressive bone marrow failure predisposition malignancy hematopoietic stem cell transplantation used treat best results attained sibling donors human leukocyte antigen hla identical matches preimplantation genetic diagnosis pgd offers parents affected child opportunity unaffected child hla match research investigated parents experiences pgd process published studies specifically address factors influencing decision making process long term interpersonal outcomes aims study examine parents expectations influence media bioethics religion decision undergo pgd examine parents social support emotional experiences pgd process characterize long term effects pgd relationship dynamics partner family friends others attitudes parental regret nine parents participated semi structured interviews thematic analysis revealed decision use pgd variously influenced media bioethics religion particular affecting parents initial confidence levels moreover pgd process emotionally complex parents desiring varying amounts types support different sources different times parents reported others attitudes towards similar different pgd parental regret regarding pgd negligible results study promote optimization long term care families
fatigue cracking considered one main pathologies asphalt pavements contributing reduction service life generating high costs consequence maintenance works importance road quality society economic development techniques avoid reduce adverse effects derived cracking phenomena necessary purpose research focuses development sustainable economic solution uses reinforced polyethylene pond wastes antireflective cracking system placed asphalt pavements layers three different pavement sections studied laboratory reference one anticracking system pavement section geotextile common anticracking system similar one reinforced polyethylene pond waste results obtained mechanical performance testing showed technique could provide optimal solution reduce effect pathology offer new way valorize wastes addition comparison solutions reinforced polyethylene pond liners effective reducing propagation cracks asphalt pavement
fatigue especially mental form one worrying health problems nowadays affects health also motivation emotions feelings impact individual organizational level fatigue monitoring management assumes thus century increased importance promoted private organizations governments alike traditional approaches mostly based questionnaires paper present alternative one relies observation individual interaction computer show interaction changes onset fatigue changes significant enough support training neural network classify mental fatigue real time main outcome work development non invasive systems continuous classification mental fatigue support effective efficient fatigue management initiatives especially context desk jobs elsevier rights reserved
fatty acid functionalized chitosan conjugates great interest cancer therapeutics internalization receptor mediated endocytosis cancer cells keeping fact consideration herein synthesized undec enoic acid functionalized chitosan based undecyl chitosan nano bioconjugate use dcc coupling agent conjugate synthesized confirmed characterized ftir nmr tga xrd sem tem analysis generally well established conjugates oleic acid human alpha lactalbumin hamlet induce cytotoxicity altered cells healthy cells check presumptions anti bacterial anti cancer potential evaluated bacterial pathogens gram gram human cancer cell lines hela mda hepb results study clearly revealed conjugate showed enhance anti bacterial anti biofilm well anti cancer efficacy compared pure free form chitosan elsevier ltd rights reserved
fusion proteins important new class biotherapeutics however currently little published data behavior proteins downstream processing operations objective study evaluate ultrafiltration behavior highly purified fusion protein citrate phosphate histidine buffers wide range protein concentrations filtrate flux data obtained using pellicon tangential flow filtration cassette results analyzed using modified version recently developed ultrafiltration model accounts effects intermolecular interactions protein mass transfer suitably extended include flux pressure dependent regime key parameters model evaluated independent measurements solution viscosity osmotic pressure protein concentrations filtrate flux maximum achievable protein concentration histidine buffer significantly lower corresponding values citrate phosphate buffer due primarily greater viscosity histidine buffer modified concentration polarization model good agreement filtrate flux data full range protein concentrations pressure dependent pressure independent regime results provide important insights factors controlling ultrafiltration behavior fusion protein
feature selection one significant steps machine learning reduces features space order achieve faster learning yielding simpler models high accuracy interpretability rapid development technologies large scale high dimensional datasets common today degrades performance traditional feature selection techniques suffer scalability issues parallel feature selection obvious solution deal problem due advent many distributed computing frameworks scalable computing become viable strategy reference feature selection present work proposes distributed parallel feature selection technique employs vertical distribution strategy dataset exploit parallel computation uses information gain filter based ranking method evaluates multiple disjoint feature subsets dataset parallel key idea distribution evaluation rank generation features several computing nodes parallel experiments performed multiple large scale high dimension datasets significant reduction overall computation time achieved
feed restriction could relevant strategy preserve gut health reduce systemic inflammatory response finally limit antibiotic use study assessed effect feed restriction growing pigs submitted moderate inflammatory challenge induced degradation environmental hygiene known alter growth rate experiment run pigs selected weeks age according factorial design two feeding levels libitum feed restricted two conditions environmental hygiene clean dirty pigs housed individually throughout experiment days age day pigs housed post weaning unit feed restriction applied half pigs day day days age day experiment pigs transferred growing unit half half pigs housed dirty environment poor hygiene half clean environment good hygiene day growth performance recorded weekly blood faeces samples collected measure indicators inflammation nutrient digestibility microbiota composition faecal consistency monitored daily detect diarrhoeas feed restriction decreased daily weight gain increased feed conversion ratio digestibility reduced occurrence diarrhoeas irrespective hygiene conditions poor hygiene conditions decreased growth performance total tract digestibility nutrients haptoglobin concentrations lymphocyte granulocyte numbers higher poor hygiene conditions confirming model effective induce systemic inflammatory response feed restriction hygiene modified profile faecal microbiota study feed restriction reduce systemic inflammatory response caused poor hygiene conditions despite limitation occurrence digestive disorders however study opens discussions regarding impact hygiene feed restriction gut microbial communities digestive health
feline hepatic lipidosis fhl common potentially fatal liver disorder although pathophysiologic mechanisms fhl remain elusive imbalance influx fatty acids peripheral fat stores liver novo liposynthesis rate hepatic oxidation dispersal hepatic tag via excretion low density lipoproteins diagnosis fhl based anamnestic clinical clinicopathologic findings associated diagnostic imaging liver cytology histological examination liver biopsies fluid therapy electrolyte correction adequate early nutrition essential components therapy fhl
female inmate populations united states tend overweight physically inactive experience high stress history nicotine drug dependence thus bear elevated risk cardiovascular disease general population however evidence based health interventions exist population study test proof concept feasibility potential efficacy multiple health behavior change intervention integrates health promotion education delivered physical activity program indoor cycling tailored population study uses quasi experimental group design two measurement time points baseline week end treatment incarcerated women years age medically cleared participation enrolled indoor cycling instructors trained deliver five health education topics week period twice weekly cycling classes topics match american heart association recommendations health nutrition promotion weight management stress management smoking cessation relapse prevention modes intervention include instructor advice written materials audio video clips reviewed class related mental health measures assessed time points results guide full scale efficacy study future research area potential impact health female inmates high risk population moreover multiple health behavior change intervention model represents community approach health promotion could generalize underserved populations may benefit similar intervention efforts elsevier inc rights reserved
female perpetrated family violence difficult phenomenon understand easily conform normative gendered expectations women however women sometimes perpetrate family violence children spouses aim study describe make visible women experiences perpetrating family violence nineteen women interviewed experiences perpetrating family violence data analysed inductive content analysis three categories emerged threat losing sense self acknowledging harming behaviour challenges obtaining help categories describe women conception self feminine identity gender role expectations family violence perpetrator context female perpetrated family violence acknowledged part women behaviour would reflect shift society notions gender roles results study may used nurses encountering women perpetrated family violence development nursing policies aimed enhancing wellbeing family
ferroxidase activity reported altered various biological fluids neurodegenerative disease sources contributing altered activity uncertain assay fractions serum cerebrospinal fluid newly validated triplex ferroxidase assay data indicate ceruloplasmin multi copper ferroxidase predominant source serum activity activity csf predominantly derives kda component specifically polyanions citrate phosphate confirm human biological samples ceruloplasmin activity serum decreased alzheimer disease csf reduction activity alzheimer disease originates polyanion component
fertility rate influence country population quantity age gender structure future population changes thesis analyzes history china family planning policy resistance explores influence zero adjustment current policy birth control suggests change formation adjustment family planning policy
ferulic acid natural phytochemical gained importance potential therapeutic agent virtue easy commercial availability low cost minimal side effects derivative curcumin possesses necessary pharmacokinetic properties retained general circulation several hours therapeutic effects ferulic acid mediated antioxidant anti inflammatory properties exhibits different biological activities anti inflammatory anti apoptotic anti carcinogenic anti diabetic hepatoprotective cardioprotective neuroprotective actions etc current review addresses therapeutic effects different pathophysiological conditions cancer cardiomyopathy skin disorders brain disorders viral infections diabetes etc elsevier ltd rights reserved
fetal alcohol spectrum disorder fasd devastating disease brain caused exposure alcohol prenatal development prevalence exceeds majority fasd cases represent milder forms disease often remain undiagnosed even diagnosed treatment options patient limited due lack information mechanisms underlie disease zebrafish proposed model organism exploring mechanisms fasd laboratory studying effects low doses alcohol embryonic development zebrafish review discusses methods alcohol exposure effects behavioral performance including social behavior learning potential underlying biological mechanisms zebrafish based upon recent keynote address delivered author focuses findings obtained mainly laboratory paints promising future small vertebrate fasd research wiley periodicals inc dev psychobiol
fetal exposure environmental insults increases susceptibility late onset neuropsychiatric disorders alcohol listed one prenatal environmental risk factors known exert devastating teratogenetic effects developing brain leading complex neurological psychiatric symptoms observed fetal alcohol spectrum disorder fasd performed coordinated transcriptome analysis human mouse fetal cerebral cortices exposed ethanol vitro vivo respectively regulated genes conserved human mouse models biological annotation expression profiles included many genes terms related neural development cell proliferation neuronal migration differentiation providing reliable connection two species data indicate use combined rodent human model systems provides effective strategy reveal analyze gene expression changes inflicted various physical chemical environmental exposures prenatal development also potentially provide insight pathogenesis environmentally caused brain disorders humans
findings cognitive science proved influential composite face effect top half one face aligned bottom half another presented upright resulting composite arrangement induces compelling percept novel facial configuration findings obtained using composite face procedures contributed significantly understanding holistic face processing detrimental effects face inversion development face perception aberrant face perception clinical populations composite paradigms continue advance knowledge face perception exemplified recent use investigating perceptual mechanisms underlying dynamic face processing however paradigm subject intense scrutiny particularly last decade growing sense composite face illusion whilst easy illustrate deceptively difficult measure interpret review provide focussed overview existing composite face literature identify six priorities future research addressing gaps knowledge aid evaluation refinement theoretical accounts illusion
interventions used faith based approaches health promotion programs among latinos notably religious population article explores perceptions church leaders promotoras program participants catholic religious context content community based intervention addressing physical activity nutrition stress management chicago latinas aged nineteen depth interviews conducted viewed trustworthy natural authentic church setting nurtured community bonds moreover program religious content encouraged latinas feel motivated connected engaged program meaningful ways overall faith based health promotion programs offer promising approach latino centered interventions
research developed early intervention models deployed tested real world preschool programs study teaching staff implemented social communication modularized intervention jasper daily program sixty six preschool children autism twelve classrooms teachers randomized receive immediate jasper training waitlisted months month follow measures core deficits initiations joint engagement joint attention gestures language play skills standardized cognitive measures improved children teachers achieved maintained high fidelity teachers implement evidence based interventions significant improvements core deficits children asd
studies identified effects arthroscopic surgery clinical outcomes open wedge high tibial osteotomy owhto arthroscopic surgery performed together purpose study evaluate clinical efficacy arthroscopic surgery patients varus osteoarthritic knee treated owhto combined arthroscopic surgery among knees patients underwent owhto january march knees patients years follow reviewed retrospectively patients divided two groups group knees underwent owhto group knees underwent owhto combined arthroscopic surgery clinical evaluation range motion rom pain visual analog scale knee society knee score knee society function score complication used radiologic evaluation kellgren lawrence grade mechanical femorotibial angle posterior tibial slope used average follow period months group showed significant increase rom last follow degrees compared preoperative time point degrees comparison radiologic parameters groups significant difference minimum month follow owhto combined arthroscopic surgery performed arthroscopic surgery helped increase rom patients mechanical symptoms however amount rom increase degrees unknown clinical significance
digital scheduling system realize functions centralized monitoring remote maintenance fault diagnosis environmental monitoring etc remote equipment attended way railway scheduling station station communication adapt future development railway communication paper describes common faults processing methods application digital dispatching system
fibrosis characteristic chronic kidney diseases recognized independent predictor disease progression deposition pathological matrix walls glomerular capillaries interstitial space around arterioles predicts contributes functional demise nephron surrounding vasculature recent identification major cell populations fibroblast precursors kidney interstitium pericytes tissue resident mesenchymal stem cells glomerulus podocytes parietal epithelial mesangial cells enabled study fibrogenic process much greater depth directly fibroblast precursors cells matrix producing cells also important innate immune surveillance cells regulate inflammatory process exacerbate tissue damage release radicals cytokines contribute parenchymal microvascular dysfunction aberrant wound healing responses innate immune signaling fibroblasts precursors intimately intertwined process fibrogenesis addition genomic genetic studies also point defective responses loci close genes involved solute transport metabolism autophagy protein handling vascular homeostasis principally epithelium endothelium upstream drivers fibrotic process indicating cellular crosstalk vital development fibrosis move beyond tgf beta inhibition central target fibrosis targeting innate immune signaling metabolic dysfunction appear increasingly tenable alternative targets novel therapies
field inversion dominates cost modern software implementations certain elliptic curve cryptographic operations point encoding hashing elliptic curves brown submission nist brown iacr cryptology eprint archive aranha cryptology eprint archive report itoh tsujii inversion using polynomial basis precomputed table based multi squaring demonstrated highly effective software implementations taverne ches oliveira cryptogr eng aranha cryptology eprint archive report performance memory use depend critically choice addition chain multi squaring tables prior work determined suboptimal hoc methods manual selection thoroughly investigated performance memory tradeoff table based linear transforms used efficient multi squaring based upon results investigation devised comprehensive cost model itoh tsujii inversion corresponding optimization procedure empirically fast provably finds globally optimal solutions tested method eight binary fields commonly used elliptic curve cryptography method found lower cost solutions hoc methods used previously first time enables principled exploration time memory tradeoff inversion implementations
filament growth breakup investigated context ceramic inkjet printing several inks formulated ejected printer dedicated ceramic materials consisted six colloidal inks four simple fluids two graphic inks stroboscopic snapshots acquired filament shape extracted analysed different nozzle actuation pulses filament length thread minimum radius measured ejection process scaling breakup time rayleigh number obtained well general behaviour filament growth rate ejection process elsevier ltd rights reserved
finding connected components fundamental task applications dealing graph analytics social network analysis web graph mining image processing exponentially growing size today graphs required definition new computational models algorithms efficient processing highly distributed architectures paper present cracker efficient iterative mapreduce like algorithm detect connected components large graphs strategy cracker transform input graph set trees one connected component graph nodes iteratively removed graph added trees reducing amount computation iteration prove correctness algorithm evaluate computational cost provide extensive experimental evaluation considering wide variety synthetic real world graphs experimental results show cracker consistently outperforms state art approaches terms total computation time volume messages exchanged
finding simple reliable mathematical models describing complex process difficult task deriving reasonably model frequently find necessary ignore certain properties system active disturbance rejection control adrc method require detailed mathematical description system supposes unmodeled elements dynamics external disturbances estimated trough extended state observer eso rejected adding estimate control law work input output behavior coupled tanks system approximated second order uncertain model allows employing linear quadratic regulator lqr approach design proportional integral derivative pid controller adrc framework proposed criterion selecting weighting matrices lqr order desired percentage overshoot settling time closed loop system response
findings presented regarding childcare providers use evidence based strategies promote preschoolers social emotional competence urban childcare classrooms descriptive results classroom observations childcare teachers interviews indicated absence training childcare teaching staff implemented strategies teachers also reported lack infrastructure elements professional development leadership team data based tools decision making monetary resources associated adoption sustained use strategies findings described recommendations presented support implementation practices associated young children social emotional competence childcare settings
fingolimod oral disease modifying drug relapsing remitting multiple sclerosis preventing egress cells lymph nodes relevant first dose adverse events include bradycardia atrioventricular conduction slowing cardiac side effects fingolimod combinational pharmacotherapy including duloxetine tolterodine monitored mice different age using implantable ecg telemetric systems cardiac tissue assessed receptor subtype girk expression fingolimod led significant heart rate reduction within min returned baseline values within older mice bradycardia pronounced compared younger mice atrioventricular conduction affected older mice showed higher spr expression state receptor expression reduced fingolimod administration combination duloxetine tolterodine alleviated fingolimod induced heart rate decrease data provide preclinical evidence negative chronotropic effects fingolimod might age dependent possibly due altered expression internalization cardiac spr older animals data could relevant future clinical monitoring patient selection aging population combinational therapies fingolimod duloxetine tolterodine well tolerated safe without increased risk pronounced bradycardia arrhythmia
first impressions social traits trustworthiness dominance reliably perceived faces despite questionable validity considerable real world consequences sought uncover information driving judgments using attribute based approach attributes physical facial features objectively measured feature positions colors database highly variable ambient face photographs used input neural network model factor dimensions approachability youthful attractiveness dominance thought underlie social attributions linear model based approach able account variance raters impressions previously unseen faces factor attribute correlations could used rank attributes importance factor reversing process neural networks used predict facial attributes corresponding image properties specific combinations factor scores way factors driving social trait impressions could visualized series computer generated cartoon face like images depicting attributes change along dimension study shows despite enormous variation ambient images faces substantial proportion variance first impressions accounted linear changes objectively defined features
first using delphi method field trips literature research method builds manufacturing engineering enterprise standardized management index system second using ahp calculates index weights manufacturing engineering enterprise standardization management system third study constructs manufacturing engineering enterprise standardized management hierarchy model manufacturing engineering standardized management maturity model built last provides reference manufacturing engineering enterprise grasping overall standardization management level enterprise improve overall standardized management level
five decades research shown clear links exposure violent visual media subsequent aggression however little research directly compares effects exposure violent visual versus auditory media experimentally tested effect violent song lyrics musical tone held constant current study participants heard music either without lyrics without violent music video given chance aggress using hot sauce paradigm musical tone held constant across groups fifth control group media exposure experimental groups average significantly aggressive controls strongest effect elicited exposure violent lyrics regardless whether violent imagery accompanied music regardless various person based characteristics implications theories media violence models aggression discussed elsevier inc rights reserved
five homologous acetylated acylglycerols hydroxyfatty acids chain lengths named euphrasianins characterized first time euphrasia rostkoviana hayne orobanchaceae gas chromatography mass spectrometry high performance liquid chromatography atmospheric pressure chemical ionization mass spectrometry hplc apci msn addition mass spectrometric data structures euphrasianins verified via three step total synthesis one representative homologue euphrasianin structure latter confirmed nmr experiments well high resolution electrospray ionization mass spectrometry esi absolute configuration hydroxyfatty acid moiety found natural euphrasianins determined alkaline hydrolysis methylation purified fraction followed chiral analysis furthermore extracts euphrasia tetraquetra breb arrond euphrasianins detected exclusively indicating subclass lipid constituents possibly valuable fingerprinting methods
five years passed since japanese pediatric guideline food allergy jpgfa first revised original version many scientific papers related food allergy published last years second major revision jpgfa carried guideline food allergies generally classified four clinical types neonatal infantile gastrointestinal allergy infantile atopic dermatitis associated food allergy immediate type food allergy urticaria anaphylaxis etc special forms immediate type food allergy food dependent exercise induced anaphylaxis oral allergy syndrome oas much guideline covers immediate type food allergy seen childhood adolescence infantile atopic dermatitis associated food allergy type especially important onset food allergies occurs infancy discussed neonatal infantile gastrointestinal allergy special forms immediate type food allergy types separately diagnostic procedures highlighted probability curves component resolved diagnosis including recent advancement utilizing antigen specific ige oral food challenge using stepwise approach recommended avoid complete elimination causative foods although oral immunotherapy oit approved routine treatment nationwide insurance included chapter oit focusing efficacy problems prevention food allergy currently focus interest many changes made based recent evidence finally contraindication adrenaline antipsychotic drugs japan discussed among related medical societies reached agreement use adrenaline allowed based physician discretion conclusion guideline encourages physicians follow principle let patients consume causative foods way early possible copyright japanese society allergology production hosting elsevier
fixed geo satellite communications impaired long rtts possible presence packet losses satellite radio channel moreover satellite receiver mobile short long disruptions due line sight obstructions cause performance deterioration paper present preliminary assessment disruption impact performance comparing different approaches end end tcp pep based tcp splitting dtn performance evaluated linux testbed emulating satellite link interruptions caused tunnels real railway tine results show good performance achieved approaches considered provided satellite channel efficient tcp variant like hybla adopted however dtn offers best performance dtn superiority emerges disrupted satellite channel lost leg congested path thanks dtn custody transfer mechanism store forward capability
fixed parameter algorithms approximation algorithms moderately exponential algorithms three major approaches algorithm design active increasing attention connection different frameworks particular whether independent set would better approximable endowed subexponential time fpt time central question article provide new insights question using two complementary approaches former makes strong link linear pcp conjecture inapproximability latter builds class equivalent problems approximation subexponential time
binding protein fkbp chaperone heat shock protein significantly influences glucocorticoid receptor sensitivity single nucleotide polymorphisms snps fkbp gene associated altered hypothalamus pituitary adrenal hpa axis function changes structure function several cognitive brain areas increased susceptibility post traumatic stress disorder major depression bipolar disorder suicidal events mechanisms underlying associations largely unknown speculated influence snps emotional memory systems may play role present study participants exposed socially evaluated cold pressor test stress control stress conditions immediately prior learning list words participant memory assessed immediately learning free recall later free recall recognition participants provided saliva sample enabled genotyping three fkbp polymorphisms results showed stress impaired immediate recall risk allele carriers importantly stress enhanced long term recall recognition memory non carriers risk alleles effects completely absent risk allele carriers follow analyses revealed memory performance correlated salivary cortisol levels non carriers carriers findings suggest fkbp risk allele carriers may possess sensitized stress response system perhaps specifically stress induced changes corticosteroid levels might aid understanding snps fkbp gene confer increased risk stress related psychological disorders related phenotypes
flanders hilbert space finite power theory infinite networks extended networks zemanian new approach uses approximation finite networks priori bounds gain properties arzela ascoli continuous function space paper compares contrasts reconciles existence uniqueness theories
flash based fpgas frequently used space applications common designs include small microcontroller paper present results detailed study two implementations arm cortex processor first implementation uses standard design flow second implementation protected rhbd techniques including tmr flip flops designs tested using heavy ion micro beam using methodology enables individual ions localized space time rate silent data corruption sdc reduced protected version many error scenarios reproduced using simulation based fault injection overall results suggest contribution single event transients sets neglected results show limitations flip flop based tmr
flexible bed sills extensively used rivers several applications protect pipeline crossings slope control enhance environmental aspects use riprap provides flexibility required adjust small changes river bed level makes material one commonly used shear failure riprap extensively studied little knowledge available edge failure flexible bed sills design required extent sills protect assets experimental work large test facility carried gain improved understanding flat sills sills protruding bed significantly lower depth length scour hole observed downstream edge flat riprap sills rigid sills existing equations rigid bed sills found appropriate estimating scour flexible bed sills tested expected protrusion enhances scour potential significantly found scour depths order greater associated flat sills research provided useful evidence avoiding placement pipelines straight river beds instead adopt trenches whenever feasible
flexible hybrid electronics combine best characteristics printed electronics silicon ics create high performance ultra thin physically flexible systems new static dynamic tests developed evaluate performance systems dynamic radius curvature torsional test results presented flexible hybrid electronics system flex silicon polymer operational amplifier manufactured cmos process levels metal interconnect mounted pet substrate
floating gate mos transistor fgmos proved suitable low voltage analog applications owing threshold voltage programmability tutorial paper presents fgmos based circuit structures applications analog signal processing fgmos based current mirror application voltage controlled current source presented performance structures verified using pspice simulations cmos technology number
flow patterns around bodies undergoing flow induced vibrations biomimetic flows intriguing similarities similar flow mechanisms used understand principal properties find ways alter behavior long history extensive study flow structure interaction allowed rapid development new field biomimetic fluid mechanics return properties revealed discoveries made study swimming fish cetaceans bird flight entering engineering domain suggesting new ways control flow devise new technology well invigorating profession
fluvial dynamics riverine borders play important role political relationships countries rivers move evolve influence natural processes external drivers land use change river catchments hirmand river important riverine border iran afghanistan present study shows evolution lateral shifting hirmand river along international border period decades seven data series aerial photos topographic maps landsat images used analyze land cover channel changes study reach land cover changed dramatically sides border last decades especially afghan part overall land surface changed cover type especially area agriculture residential land contributed increase surface area respectively hand natural cover water bodies decreased respectively impact land use changes morphological evolution hirmand river investigated sub reaches found average decrease active channel width years average river network change index whole study reach years year deposition narrowing turned main processes occurring within study reach furthermore due natural riverine processes hirmand river moved towards afghanistan average lateral shifting found sections elsevier rights reserved
follicular thyroid carcinoma ftc aggressive form thyroid cancer common papillary type alpha sialyltransferase stsia family members expressed various cancers may associated ftc progression study measured stsia family expression two ftc cell lines different invasive potentials ftc ftc nthy ori cell lines well ftc normal thyroid tissues stsia downregulated highly invasive ftc cells ftc tissues additionally stsia inhibited proliferation migration invasion ftc vitro vivo mir mir previously shown upregulated thyroid carcinoma bioinformatics analyses indicated mir mir inhibit stsia found mir mir significantly upregulated ftc promoted tumour progression furthermore stsia restoration decreased invasiveness mir overexpressing ftc cells stsia suppression reversed effects mir inhibition ftc cells showed mir activated pik akt mtor signalling pathway least partially via suppression stsia thus results demonstrate mir mir promote proliferation migration invasion ftc via inhibition stsia
food allergies become global challenge food safety industrialized countries recent years governmental monitoring legislation moving towards establishment threshold allergen doses need sensitive quantitative analytical methods determination allergenic food contaminants targeted proteomics employing liquid chromatography mass spectrometry emerged promising technique offers increased specificity reproducibility compared antibody dna based technologies detection trace levels allergenic food contaminants also demands excellent sensitivity aimed significantly increase analytical performance utilizing multiple reaction monitoring cubed mrm technology following bottom proteomics approach including straightforward sample preparation process mrm experiments specific proteotypic peptides developed optimized permitted highly specific identification peanut almond cashew hazelnut pistachio walnut analytical performance method assessed three relevant food matrices different chemical compositions limits detection around fortified matrix samples accounting effects food processing compared mrm based approach mrm based method showed increase sensitivity fold regression analysis demonstrated high linearity mrm signal spiked matrix samples together robust intersample reproducibility confirming method highly applicable quantitative purposes best knowledge describe sensitive multi method food allergen detection thus far addition first study systematically compares mrm mrm analysis complex foods
food assistance recipients higher risk poor cardiovascular health given propensity poor dietary intake tobacco use study sought evaluate cardiovascular health status determine impact low intensity smoking cessation education intervention connected mobile food pantry participants state quit smoking resources pre post design week follow used evaluate impact min smoking cessation education session implemented five food pantries delaware baseline cardiovascular health smoking behaviors food security status assessed smoking cessation knowledge intention quit use state quit line also assessed follow participants reported hypertension diabetes stroke current smokers low intensity intervention significantly increased smoking cessation knowledge intention quit follow seven percent current smokers reported calling quit line current tobacco use five times likely food insecure versus food secure adults even adjustment demographic factors systems based approaches address tobacco use cardiovascular health low income populations needed extent smoking cessation could reduce food insecurity risk cardiovascular disease population warrants investigation
food insecurity among children families negatively affects children health well link household resources food insecurity well established family income alone explain food insecurity neighborhood disadvantage shown affect areas children development may also play role food insecurity study examines associations neighborhood poverty children food insecurity whether family characteristics account identified associations merge data kinder garten age children early childhood longitudinal study kindergarten cohort ecls data poverty rates american community survey acs food access usda food environment atlas using children residential census tracts children tracts using series multilevel models test associations neighborhood poverty household economic demographic parenting characteristics food insecurity child adult household levels children living higher poverty neighborhoods likely experience food insecurity lower poverty neighborhoods associations neighborhood poverty household adult level food insecurity disappear household characteristics controlled however living high poverty neighborhood remains predictive child level food insecurity may indicator severe hardship findings indicate neighborhood poverty may useful proxy identify vulnerable children elsevier ltd rights reserved
foods consumed children without parental supervision always healthy cause disease especially digestive diseases children knowledge happening digestive reaction consuming food avoid consuming bad food health medium used convey games activities mobile application app called nomnom research conducted field references studies children favorite character similar mobile apps character design accordance simple yet attract children attention
given septic bezier curve distinct ordered sequence control points determine whether curve via exact symbolic computation theory problem motivated study necessary sufficient condition planar septic bezier curve possess pythagorean hodograph based definition curve complex representation planar curve develop geometric conditions terms leg lengths angles control polygon must separated guarantee property relation compatibility solutions respect complex coefficients equations geometric constraints analyzed moreover septic curves inflections extended construct shaped transition curves elsevier rights reserved
long distance water transfer system guaranteeing safety water transferred long open canal challenge potential pollution sources locations identified first bridges canal considered typical location pollution accidents could happen truck responses road conditions human responses main factors resulting sudden pollution accidents bayesian network model developed calculate risk water pollution evaluate effects pollutants water key causes human judgment truck condition determined calculate unfavorable accidental risk six types hydraulic structures included canal reach mike one dimensional hydrodynamic water quality model used simulate fluid field pollutants transportation process water quality situations cyanide four pollution loads simulated emergent countermeasures measures including management diversion check gate proposed according calculate result elsevier rights reserved
centuries highest level mathematics seen isolated creative activity produce proof review acceptance research peers mathematics remarkable inflexion point new technology radically extending power limits individuals crowdsourcing pulls together diverse experts solve problems symbolic computation tackles huge routine calculations computers using programs designed verify hardware check proofs long complicated human comprehend social machines new paradigm identified berners lee viewing combination people computers single problem solving entity paper outlines research agenda new vision mathematics social machine combination people computers archives create apply mathematics places context verification research computational logic roy dyckhoff pioneering work computer proof
children serious persistent academic behavior problems parent involvement education particularly teacher perceptions involvement essential avert expected long term negative outcomes despite widespread interest perceived importance parent involvement education however experimental studies evaluated programs practices promote group randomized trial examined effects incredible years teacher classroom management program tcm teacher perceptions contact comfort parents one hundred five classrooms students randomly assigned tcm control business usual condition measures key constructs included teacher ratings parent student behaviors direct observations classroom standardized academic achievement test latent transition analysis lta used identify patterns involvement time determine intervention condition predicted postintervention patterns transitions four patterns involvement identified baseline follow parents students academic behavior problems likely classes least adaptive involvement patterns intervention status predicted group membership follow specifically intervention classroom parents significantly likely transition adaptive teacher rated parenting profiles follow compared control classroom parents first randomized trial aware found teacher training alter teacher perceptions parent involvement patterns clinical implications students behavior academic problems discussed
decades increasing intergroup contact preferred method improving cooperation groups however even proponents approach acknowledge intergroup contact may effective context intractable conflicts one question whether anything done increase impact intergroup contact cooperation present study tested whether changing perceptions group malleability pre encounter intervention could increase degree cooperation contact encounters jewish palestinian israeli adolescents randomly assigned either condition taught groups malleable coping control condition subsequent intergroup encounter used two behavioral tasks estimate levels cooperation results indicated relative controls participants group malleability condition showed enhanced cooperation findings suggest new avenues enhancing impact contact context intractable conflicts
military personnel positive negative aspects marriage may contribute mental health times high stress present study investigated relationship marital status three mental health outcomes general mental health posttraumatic stress disorder ptsd depression among canadian military personnel recently deployed support mission afghanistan greater combat exposure associated poorer postdeployment mental health marital status slightly associated ptsd marital status significantly moderated relationship combat exposure mental health single married participants mental health declined combat exposure increased association stronger married members association could due additional familial demands married personnel may face upon return deployment stresses associated poor marital satisfaction overall results suggest relationship marital status mental health deployment complex may vary according factors
years motor interference paradigms used investigate influence action observation action execution research called automatic imitation focused variables play modulating role investigated potential confounding factors interestingly furthermore number functional magnetic resonance imaging fmri studies tried shed light functional mechanisms neural correlates involved imitation inhibition however fmri studies presumably due poor temporal resolution primarily focused high level processes neglected potential role low level motor perceptual processes current eeg study therefore aimed disentangle influence low level perceptual motoric mechanisms high level cognitive mechanisms focused potential congruency differences visual component related processing biological motion readiness potential component related motor preparation high level component interestingly detected congruency effects components suggesting interference effect automatic imitation paradigm related high level processes self distinction also low level influences perception action action perception moreover documented relationships neural effects autistic behavior
neurodegenerative conditions like parkinson disease early accurate diagnosis still difficult task evaluations time consuming patients must often travel metropolitan areas different cities see experts misdiagnosis result improper treatment date handful assistive remote methods exist help physicians evaluate patients suspected neurological disease convenient consistent way paper present low cost interface designed support evaluation diagnosis neurodegenerative disease test use clinical setting using commercially available display infrared camera integrated lens constructed virtual environment designed emulate common tasks used evaluate patients fixating point conducting smooth pursuit object executing saccades virtual tasks designed elicit eye movements commonly associated neurodegenerative disease abnormal saccades square wave jerks ocular tremor next conducted experiments patients diagnosis parkinson disease healthy controls test system potential emulate tasks clinical diagnosis applied eye tracking algorithms image enhancement eye recordings taken experiment conducted short follow study two physicians evaluation results showed interface able elicit five common types movements usable evaluation physicians able confirm three four abnormalities visualizations rated potentially useful diagnosis
oblique arch curved beam space oblique composite system suspension bridge whose force transmission path spatial stress complex robustness characteristics strong engineering experience used reference order analyse wind resistant performance tongtai bridge aeroelastic model bridge designed fabricated accurately simulating flow field boundary layer field using wind tunnel test technique calculated vortex vibration buffeting aerodynamic stability arch rib whole bridge uniform flow field turbulent flow field different attack angle angle condition experimental results show bridge good aerodynamic stability obvious vortex vibration occurs vertical lateral displacement arch rib section higher crown meets requirement wind resistance
self anchored suspension bridges fabrication camber subjected live loads new deflection theory formulated optimized initial state solution found dead loads analytical solution three span continuous suspension bridges consistently derived considering tower effects compared derived conventional deflection theory earth anchored bridges hand unstrained length method ulm keeps element lengths constant nonlinear iteration process extended applied nonlinear finite element analysis suspension bridges live loads finally earth anchored self anchored bridge examples analytically numerically solved using two methods numerical results compared verify accuracy effectiveness proposed deflection theory ulm american society civil engineers
facing prosocial request feels like trapped rock hard place requiring either resource money psychological self reproach cost outcomes dissatisfying propose people motivated avoid prosocial requests even face requests private anonymous contexts two experiments participants anonymity privacy assured participants avoided facing prosocial requests willing personal cost true people would otherwise complied request would otherwise refused request suggests anticipatory self reproach motivates people avoid prosocial requests regardless whether self reproach would strong enough cause comply direct request discuss theoretical practical implications findings prosocial behavior maintenance moral self regard elsevier inc rights reserved
successful software system maintenance efforts dominate initial development costs far however research practice still place attention initial development phase consequence companies suffer mission critical systems extremely hard maintain better support practitioners writing maintainable software need empirically sound understanding software properties help hinder maintenance tools useful practice requires work includes research practitioner perspectives article outline work towards goal
dimensional gardner equation truncated painleve method developed obtain nonlocal residual symmetry bucklund transformation symmetry group transformation computed extended system moreover dimensional gardner equation proved consistent riccati expansion cre solvable help riccati equation cre method obtain soliton cnoidal wave interaction solution equation physical society republic china taiwan published elsevier rights reserved
balanced consumption rare earth elements cerium partially used ndfeb magnets instead corrosion behaviour feb magnet different contents nacl solution investigated sem xrd eds electrochemical tests immersion weight loss calculated magnetic properties samples measured results showed affected corrosion feb magnet compared ndfeb magnet without grade magnetic energy product feb magnet showed better corrosion resistance increased content corrosion resistances magnetic properties feb magnets investigated elsevier rights reserved
many application domains concerning entities connections often data formally represented graphs important problem detecting anomalous subgraph within numerous methods proposed speed anomalous subgraph detection however incurs non trivial costs detection accuracy paper formulate anomalous subgraph detection problem maximization non parametric scan statistic approximate submodular maximization problem propose two parallel algorithms non coordination anomalous subgraph detection ncasd coordination anomalous subgraph detection ucasd anomalous subgraph detection best knowledge paper first solve problem parallel ncasd emphasizes speed expense approximation guarantees ucasd achieves higher approximation factor additional coordination controls reduced parallelism experiments demonstrate effectiveness efficiency proposed approaches real world application domain water pollution detection comparing five state art methods copyright john wiley sons ltd
time dependent control problems class sub optimal algorithms popular parallelization usually applied spatial dimension paper develop class fully optimal methods based space time domain decomposition methods boundary distributed control fluid flow heat transfer problems fully optimal approach focus use inexact newton solver necessary optimality condition arising implicit discretization optimization problem use one level two level space time overlapping schwarz preconditioners jacobian system show numerical solution fully optimal approach generally better solution sub optimal approach terms meeting objective optimization problem demonstrate robustness parallel scalability efficiency proposed algorithm present numerical results obtained parallel computer thousand processors
young children autism spectrum disorders one choice interventions early intensive behavioral intervention past ten years effectiveness abundantly evaluated based various parameters including intensity duration intervention despite major advances effectiveness evaluation data concerning implementation intervention often described briefly active ingredients intervention rarely linked documented effects objectives study aims reviewing systematic method studies pertaining eibi provided children autism spectrum disorders past ten years documenting program implementation components described studies based dane schneider model accordance prisma guidelines results results show although variables related intervention dosage protocol relatively well described authors always consider effects analysis furthermore majority studies report information intervention participation differentiation quality conclusions data concerning implementation intervention partially described articles retained regard better description intervention provided systematic evaluation implementation seem necessary detect subtle differences effects intervention elsevier ltd rights reserved
forecasting output power solar systems required good operation power grid optimal management energy fluxes occurring solar system forecasting solar systems output essential focus prediction solar irradiance global solar radiation forecasting performed several methods two big categories cloud imagery combined physical models machine learning models context objective paper give overview forecasting methods solar irradiation using machine learning approaches although lot papers describes methodologies like neural networks support vector regression shown methods regression tree random forest gradient boosting many others begin used context prediction performance ranking methods complicated due diversity data set time step forecasting horizon set performance indicators overall error prediction quite equivalent improve prediction performance authors proposed use hybrid models use ensemble forecast approach elsevier ltd rights reserved
forensic clinical anatomy new practical application discipline clinical anatomy ascertaining evaluating medicolegal questions particular individual anatomy normal anatomy anatomical variations age disease surgery related modifications acquire significant relevance various fields legal medicine child abuse sudden death medical responsibility liability personal injury damage anatomical data forensic interest frequently arise correct application methods ascertainment anatomical methods may required comprehensive analysis rigorous interpretation anatomical data derived ascertainment phase analyzed basis pertinent literature pivotal correct application evaluation criteria various forensic contexts clin anat wiley periodicals inc
forest management agroforestry tree planting key approaches sustainable rural development climate change adaptation mitigation west african savannas however planning land management interventions hindered lack information relevant spatial resolution examined predictive models mapping various tree soil species diversity attributes comparison rapideye landsat imagery field data collected vicinity community managed forest southern burkina faso main environmental threats agricultural expansion fuelwood extraction modelling done using random forest algorithm according results tree crown cover correlated attributes basal area tree species richness predicted accurately high spatial resolution rapideye imagery provided best accuracy difference medium resolution landsat imagery negligible attributes burn scar masked landsat time series performed similar dry season single date landsat imagery former avoids image selection mosaicking could less sensitive artifacts due burn scars presented approach provides valuable information important tree soil species diversity attributes spatial planning land management interventions elsevier ltd rights reserved
formal verification plays crucial role dealing correctness systems previous work authors proposed class models unary resource description framework petri nets rdf integrated petri nets rdf based semantic information work also proposed model checking approach analysis system behavioural properties made use net reachability graph computing graph specially dealing high level structures rdf graphs expensive task must considered paper describes development parallel solution computation reachability graph rdf models besides paper presents experimental results tool deployed cluster cloud frameworks results show improvement total time required computing graph also high scalability solution make useful thanks current future availability cloud infrastructures copyright john wiley sons ltd
fracking become hot topic media public discourse economic benefit also environmental impacts recently scientists investigated environmental impacts fracking studies focus air ground water pollution systematic research structure overall evaluation fraddng impacts environment needed fracking influence ground water environmental elements including limited air water soil rock vegetation wildlife human many ecosystem components standpoint total environment communication assesses overall impacts fracking environment designs total environmental study paradigm effectively examines complicated relationship among total environment fracking dramatically changes anthroposphere turn significantly impacts atmosphere hydrosphere lithosphere biosphere significant input output water air liquid solid waste disposals complex chemical components fracking fluids proposed total environment study paradigm fraddng applied significant human activities dramatic impacts environment mountain top coal mining oil sands environmental studies elsevier rights reserved
fragile premutation carriers cgg repeats untranslated region fmr gene women premutation face many physical emotional challenges life approximately women develop fragile associated primary ovarian insufficiency fxpoi addition suffer increased rates menstrual dysfunction diminished ovarian reserve reduction age menopause infertility dizygotic twinning risk offspring premutation full mutation consequent chronic hypoestrogenism may result impaired bone health increased cardiovascular risk neuropsychiatric issues include risk developing fragile associated tremor ataxia syndrome neuropathy musculoskeletal problems increased prevalence anxiety depression sleep disturbances independent stress raising offspring fragile syndrome higher risk postpartumdepression studies reported higher prevalence thyroid abnormalities hypertension women reproductive health providers play important role health supervision women fragile premutation awareness risks correlation various manifestations could help early diagnosis coordination care services women families paper reviews current evidence regarding possible conditions may present women premutation sized repeats beyond fxpoi
frailty associated inferior survival increased resource requirements among kidney transplant candidates assessments time intensive costly require direct patient interaction waitlist hospitalization may proxy patient fitness could help risk poor outcomes examined united states renal data system data adult end stage renal disease patients continuous medicare coverage waitlisted transplant january december heavily admitted patients higher subsequent resource requirements increased waitlist mortality decreased likelihood transplant death listing days hazard ratio confidence interval days days days graft recipient survival inferior higher admissions although survival benefit preserved model including waitlist admissions alone performed better statistic predicting postlisting mortality estimated posttransplant survival statistic although heavy burden admissions may still benefit kidney transplant less utility derived allografts placed population current kidney allocation policy based part longevity matching could significantly improved consideration hospitalization records transplant candidates
freshwater lake sediments support variety submerged macrophytes may host groups bacteria exerting important ecological functions collected three kinds commonly found submerged macrophyte species ceratophyllum demersum vallisneria spiralis elodea nuttallii investigate bacterial community associated rhizosphere sediments high throughput pyrosequencing bioinformatics analyses performed examine diversity composition bacterial community results obtained indicated diversity bacterial community associated rhizosphere sediments submerged macrophytes significantly lower bulk sediment remarkable differences bacterial community composition rhizosphere bulk sediments also observed
friction phenomenon involving elastic interactions plastic deformation failure processes different length scales friction coefficient one relevant parameters rolling contact railway wheels rails model dry friction established based method movable cellular automata mca influence pressure sliding velocity investigated means large number numerical simulations general qualitative conclusion fact dynamic processes plastic deformation fracture nanolevel great importance within model contact temperature also considered influence strength materials new friction law applied calculation stresses deformations tractive forces wheel rail contact rough surfaces thus understanding physical background dry friction engineering applications considerably improved elsevier rights reserved
frictionless plain bearing post tensioned slab ground new method building large concrete slabs ground frictionless support developed vienna university technology austrian patent method granted international patent application filed feasibility new method demonstrated large field tests concrete slab strips length width thickness frictionless support obtained first placing air tight membrane geotextile last second air tight membrane ground concrete slab built next step membranes sealed boundary casting slab top second membrane low air pressure applied clearance two membranes clearance created geotextile shortening slab due loss hydration heat early shrinkage post tensioning possible without causing friction forces slab subsoil self weight slab balanced applied air pressure
frogeye leaf spot fls caused fungus cercospora sojina one important soybean diseases cause great yield losses several studies demonstrated silicon enhances plant antioxidant system especially subjected stresses thus study designed evaluate effect soybean resistance fls antioxidant system concentration reactive oxygen species cellular damage infection process sojina plants cultivars bossier conquista susceptible resistant fls respectively supplied either non inoculated inoculated sojina fls severity greater bossier conquista regardless supply increased cultivars activities antioxidant enzymes lower plants plants inoculated inoculated plants usually showed increased enzyme activities higher concentrations ascorbate reduced glutathione non inoculated plants regardless supply advanced stages fungal infection inoculated plants bossier higher activity antioxidant enzymes higher concentrations superoxide malondialdehyde compared non inoculated plants result increased oxidative stress results study provide first evidence reduces basal activity antioxidant enzymes soybean leaves leading increase host susceptibility fls
fronto limbic brain networks involved regulation impulsivity aggression abnormal borderline personality disorder bpd however unclear whether extent personality traits actually modulate brain responses cognitive processing using fmri examined effects trait impulsivity aggression depressed mood regional brain responses female bpd control subjects task using ekman faces targets first level contrasts modeled effects negative emotional context second level regression models used trait impulsivity aggression depressed mood predictor variables regional brain activations bpd trait impulsivity positively correlated activation dorsal anterior cingulate cortex orbital frontal cortex ofc basal ganglia dorsolateral prefrontal cortex areas negative correlation contrast aggression negatively correlated activation ofc hippocampus areas positive correlation depressed mood generally dampening effect activations effects trait impulsivity healthy controls differed effects bpd suggesting disorder specific response negative emotional context trait impulsivity aggression depression diminished task performance across groups negative emotional context may interfere cognitive functioning bpd interaction neurobiology personality traits
fuel shortage energy crisis boundless dumping greenhouse gases atmosphere challenging issues human societies overcome energy related environmental problems solar conversion carbon based fuels promising route achievable atomistic hydrogenation molecules inside semiconductor assisted water photosplitting reactors paper using facile hydrothermal method eco friendly low price nanocomposite solar energymaterial synthesized absence presence carbon nanotube cnt applied aqueous media photochemical synthesis ethanol oxalic acid formaldehyde enhancing power cnt photocatalyst performance explained detail terms ability harvest incident photons temporarily store atoms increase surface area improve charge separation phenomenon based atomistic hydrogenation hypothesis reaction scheme finally proposed photochemically synthesized product elsevier ltd rights reserved
full packet analysis firewalls intrusion detection although effective found recent times detrimental overall performance networks receive large volumes throughput reason partial packet analysis technologies netflow protocol emerged better mitigate bottlenecks log generation paper researches use log files generated netflow version ipfix identify successful unsuccessful exploit attacks commonly used automated systems malicious communications include limited exploits attack microsoft rpc samba ntp network time protocol irc internet relay chat attacks recreated existing exploit implementations metas ploit hand crafted reconstructions exploits via known documentation vulnerabilities attacks monitored preconfigured virtual testbed containing gateways network connections commonly found internet common attack identification system intended insertion parallel module bolvedere order increase bolvedere system attack detection capability
functional electrode materials play increasingly important role advancement energy conversion storage technologies used batteries electrolyzers supercapacitors fuel cells electrochemical devices address problems related accelerating demand called renewable energy simultaneously coupled environmental concerns new generations materials engineering methodologies innovative techniques necessary among many synthetic methods microwave assisted synthesis becomes nowadays popular approach efficiently control composition morphology solids review focus applications create new advanced energy electrode materials
functional errors analog portion mixed signal circuits become severe improvements verification methods increasingly important current verification methods fall two categories simulation based verification formal verification barke focusing verifying analog circuit function performance paper proposes novel approach verifying analog circuit design using causal reasoning causal reasoning inductive reasoning process create new design flow begins mining causal reasoning steps design plan produced circuit including starting ideas design step sequence justifications jiao topological features corresponding starting ideas design step sequence verified individually replacing related devices ideal behavior model performance evaluated cadence spectre simulation comparison new circuit performance reveals incorrect functional issues performance potentials improvement negative causes certain starting ideas design steps might omitted design process paper discusses three operational amplifier designs realized cmos technology illustrate verification approach elsevier rights reserved
fungal infections like paecilomyces keratitis emerged childhood recently diagnosis treatment paecilomyces keratitis difficult outcome usually poor corneal culture performed fungal media sabouraud glucose neopeptone agar sda soon possible diagnosis report rare case paecilomyces keratitis immunocompetent child unresponsive amphotericin case managed multidisciplinary approach involving departments ophthalmology microbiology pediatric infectious diseases want draw attention fungal keratitis caused unusual agents increasing physicians consider fungal causes keratitis patients predisposing factors like ocular surgery prolonged use topical corticosteroids
gabor wavelet extract informative efficient texture features different computer vision multimedia applications features extracted gabor wavelet similar information visualized receptive field simple cells visual cortex mammalian brains motivates researchers use gabor wavelet feature extraction gabor wavelet features used many multimedia applications stereo matching face facial expression recognition fer texture representation segmentation motivates analyze gabor features evaluate effectiveness representing image paper three major characteristics gabor features established viz real coefficients gabor wavelet alone sufficient enough represent image local gabor wavelet features overlapping regions represent image accurately compared global gabor features local features extracted non overlapping regions iii real coefficients overlapping regions robust radiometric changes compared features extracted global local non overlapping regions using real imaginary magnitude information gabor wavelet efficacy effectiveness findings evaluated reconstructing original image using extracted features subsequently reconstructed image compared original image experimental results show local gabor wavelet features extracted overlapping regions represent image efficiently global non overlapping region based features experimental results also show real coefficients alone sufficient enough represent image accurately compared imaginary magnitude informations
gallstone disease associated low serum levels plant sterols evaluated impact laparoscopic roux gastric bypass lrygb non alcoholic fatty liver disease nafld association low levels serum plant sterols two hundred forty two consecutive morbidly obese patients recruited prospective study histological analysis liver biopsy diagnose nafld performed bile sample taken lrygb associations serum non cholesterol sterol cholesterol ratios measured using gas liquid chromatography mrna expression genes participating cholesterol bile fatty acid metabolism liver analyzed participants lower weight female sex associated serum plant sterols campesterol sitosterol avenasterol lower patients compared without association remained significant adjustment nafld use statin medication previous laparoscopic cholecystectomy lcc levels sitosterol campesterol remained lower obese individuals also obesity surgery liver mrna expression genes regulating cholesterol synthesis bile metabolism increased individuals serum plant sterols lower patients independent nafld history lcc use statin medication weight loss lrygb low serum plant sterols patients suggest potentially inherited alterations sterol absorption biliary transport subjects susceptible
games became popular within formal verification community application automatic synthesis circuits specifications receiving attention since paper focuses coding sokoban puzzle complex single player strategy game show solution encoded represented bounded model checking problem solved sat solver cope complex instances game propose two different hoc divide conquer strategies strategies somehow similar state art abstraction refinement schemes able decompose deep bounded model checking instances easier subtasks trading efficiency completeness analyze vast set difficult hard solve benchmark games trying push forward applicability state art sat solvers field results show games may provide one next frontier sat community
gardasil quadrivalent human papillomavirus hpv vaccine approved use food drug administration june hpv vaccine routinely recommended administration women usa years old advisory committee immunization practices previous studies suggest hpv vaccine administration associated autoimmune diseases consequence epidemiological assessment vaccine adverse event reporting system database undertaken adverse event reports associated vaccines administered year old recipients listed residence specified female gender cases serious autoimmune adverse event saae outcomes gastroenteritis odds ratio confidence interval rheumatoid arthritis thrombocytopenia systemic lupus erythematosus vasculitis alopecia cns demyelinating conditions ovarian damage irritable bowel syndrome significantly likely controls received hpv vaccine median onset initial symptoms ranged days post hpv vaccination cases outcome guillain barre syndrome likely controls received hpv vaccine addition cases known hpv related outcome syncope significantly likely controls received hpv vaccine cases general health outcomes infection conjunctivitis diarrhea pneumonia likely controls received hpv vaccine confirmatory epidemiological studies databases undertaken long term clinical consequences hpv linked saaes examined
gaussian noise important problem computer vision novel methods become popular recent years gaussian noise reduction bayesian techniques wavelet domain wavelet domain bayesian techniques require prior distribution wavelet coefficients general case wavelet coefficients might better modeled non gaussian density laplacian two sided gamma pearson type vii densities however statistical analysis textural image gaussian model require flexible model non gaussian gaussian models indeed gumbel density suitable model present new bayesian estimator gumbel random vectors awgn additive white gaussian noise proposed method applied dual tree complex wavelet transform cwt well orthogonal discrete wavelet transform dwt simulation results show proposed methods outperform state art methods qualitatively quantitatively
gender specific differences also evident adverse food reactions present article prevalence food allergies intolerances incidence different symptoms possible underlying factors summarized focus gender sex specific differences eventually becomes clear starting adolescence female male patients suffer food associated symptoms many factors held responsible among hormonal influences gender specific behavior life style processing information awareness risk intake different medications concrete studies evaluating factors context adverse food reactions still missing
gene polymorphisms lead varied structure functional properties single nucleotide polymorphism snp ileval rsl glutathione transferase gstp gene influences cytological toxicity modulates risk occupational diseases apart cancer neuropathy nox sox ozone mediated respiratory function decline including lung inflammation asthma allergy etc reported people missense mutation functional properties polymorph revisited computational approach changes incurred gstp antioxidant protein result alteration sequence studied docking followed poisson boltzmann electrostatic equation interpretation grid coulombic energy profile mapping protein polymorphs delphi molecular docking simulation variant wild type protein carried eight fda approved compounds target gstpi treatment various diseases observe binding pattern variation upon mutation induction grid reaction field coulombic energy calculation vvt mutated polymorph complexed without moieties attempted alteration conformation energy observed apo holo form gstpi ligand bound complexes result mutation study demo appraising gene environment interaction based deleteriousness molecular docking dynamics simulation approach elsevier rights reserved
general english four skills courses usually intended help learners achieve satisfactory level language proficiency focusing speaking listening reading writing skills however extent students attend kind courses well prepared communicate satisfactorily real contexts seems effective enough appears little attention usually paid aspects non verbal communication english complement spoken language must avoid future cross cultural misunderstandings contrast non verbal communication verbal communication commonly takes priority general english four skills courses paper aimed discussing importance implications incorporating teaching non verbal communication kinds courses mexican spanish speakers raise learners awareness non verbal communication issues prepare natural effective communication order carry well informed discussion issue nature main characteristics non verbal communication well significance current role efl english foreign language learning first established secondly specific comparison common patterns non verbal behavior mexican spanish speakers american british english speakers take place decide non verbal contents general english four skills course may comprise thirdly suggested teaching approach methodology activities materials teacher role teaching non verbal cues stated finally implications teaching nonverbal communication issues general english four skills courses mexican spanish speakers general conclusions discussion annotated
generally roofs best candidates rainwater harvesting context correct evaluation quantity quality runoff roofs essential effectively design rainwater harvesting systems study aims evaluate performance kinematic wave based numerical model simulating runoff sloping roofs comparing numerical results ones obtained laboratory rainfall simulations real scale lusa ceramic tile roof studied slopes simulated discharge hydrographs good adjust observed ones coefficient determination nash sutcliffe efficiency values close particularly peak discharges times peak peak durations runoff volumes well simulated
general purpose computing gpus graphics processing units emerging new paradigm several fields science although far applications tailored specific strengths devices accelerator offline computation steady reduction gpu latencies increase link memory throughput use devices real time applications high energy physics data acquisition trigger systems becoming ripe discuss use online parallel computing gpu synchronous low level trigger focusing cern experiment trigger system use gpu higher level trigger system also briefly considered elsevier rights reserved
generating synthetically mixed data library spectra provides direct means train empirical regression models subpixel mapping order best represent subpixel composition image data generation synthetic mixtures must incorporate multitude mixing possibilities lead excessive amount training samples show increasing mixing complexity training set improves model performance quantifying urban land cover support vector regression svr cope challenging increase number training samples propose use ensemble learning based bootstrap aggregation synthetically mixed training data workflow tested simulated spaceborne imaging spectrometer data acquired berlin germany comparisons svr without bagging multiple endmember spectral mixture analysis reveal usefulness methodology quantitative urban mapping
genetic environmental factors contribute risk rheumatoid arthritis epigenetics serving possible interface risk factors contribute high throughput technologies interrogating genome epigenome availability genetic epigenetic datasets across diversity cell types enable identification candidate causal genetic variants study function core processes date risk variants studied immune cells joint resident cells example synovial fibroblasts synovial fibroblasts different joints distinct anatomically specialized cells defined joint specific transcriptomes epigenomes phenotypes cell type specific analysis epigenetic changes together genetic fine mapping interrogation chromatin interactions may identify new disease relevant pathways potential therapeutic targets biomarkers progression therapy response
genetic lesions activate kras account similar million annual cases lung cancer despite clinical need kras still undruggable using traditional small molecule drugs inhibitors oncogenic kras suppressed rna interference tumors initially regress eventually recur proliferate despite suppression kras show tumor cells survive knockout oncogenic kras indicating existence kras independent survival pathways thus even clinical kras inhibitors available resistance would remain obstacle treatment kras independent cancer cells exhibit decreased colony formation vitro retain ability form tumors mice comparing transcriptomes oncogenic kras cells kras knockout cells identified genes specifically regulated kras knockout cells including fas gene encodes cell surface death receptor involved physiological regulation apoptosis antibodies recognizing fas receptor efficiently induced apoptosis kras knockout cells oncogenic kras expressing cells increased fas expression kras knockout cells attributed decreased association repressive epigenetic marks fas promoter concordant observation treating oncogenic kras cells histone deacetylase inhibitor fas activating antibody efficiently induced apoptosis thus bypassing need inhibit kras results suggest activation fas could exploited achilles heel tumors initiated oncogenic kras
genetic sequences multiple genes becoming increasingly common wide range organisms including viruses bacteria eukaryotes data may sometimes treated single locus practice number biological statistical phenomena lead phylogenetic incongruence cases different loci least preliminary step examined analysed separately software become popular platform phylogenetics several packages implementing distance based parsimony likelihood based phylogenetic reconstruction even greater number packages implementing phylogenetic comparative methods unfortunately basic data structures tools analysing multiple genes far lacking thereby limiting potential investigating phylogenetic incongruence study introduce new package apex fill gap apex implements new object classes extend existing standards storing dna amino acid sequences provides number convenient tools handling visualizing analysing data study introduce main features package illustrate functionalities analysis simple data set
genetic variations clock related genes hypothesized involved susceptibility mood disorders unipolar upd bipolar bpd disorders work investigated role gene variants form four core period proteins clock arntl tim per total sample comprised mood disorders inpatients upd bpd healthy voluntary controls snps four genes interest genotyped used single polymorphisms haplotypes snps interactions prediction analysis using classical statistical machine learning methods observed association two polymorphisms clock bpdii two polymorphisms tim upd also detected arntl haplotype variant rsc rsg rst associated increased risk bpd types established significant epistatic interaction per arntl case bpd additionally relation per clock appeared case upd classification regression trees showed significant predictive value polymorphisms analyzed genes however failed obtain model sufficient predictive power analyses sleep disturbances sample found carriers homozygote variants arntl per showing frequent falling asleep difficulties compare genotypes carriers study suggested putative role clock tim arntl per polymorphisms susceptibility analyses showed association specific gene variants particular types also confirmed necessity performing separate analyzes bpd upd patients comprehensive statistical approach required even individual symptoms analyses
genistein preventive role bone mass loss menopause however experimental data animal models osteoporosis suggest anti osteoporotic potential isoflavone performed post hoc analysis previously published trial investigating effects genistein postmenopausal women low bone mineral density parent study randomized double blind placebo controlled trial involving postmenopausal women femoral neck density cohort enrolled women fact identified baseline osteoporotic basis score analyzed thereafter months treatment either calcium vitamin placebo calcium vitamin genistein aglycone day genistein according femoral neck scores genistein placebo recipients osteoporotic baseline placebo genistein groups year hip fracture probability risk assessed fracture risk assessment tool frax respectively mean bone mineral density bmd femoral neck increased baseline year years genistein recipients decreased baseline year years placebo recipients end study postmenopausal women osteoporosis genistein group prevalence whereas placebo group number postmenopausal women osteoporosis unchanged months post hoc analysis proof concept study suggesting genistein may useful postmenopausal osteopenia also osteoporosis however proof concept study needs confirmed large well designed appropriately focused randomized clinical trial population high risk fractures
genome wide association studies gwas ethnic racial minority populations help fine map previously identified risk regions discover new risk loci genetic diversity populations conducted gwas colorectal cancer crc african americans cases controls stage followed promising markers replication set participants african descent cases controls stage identified novel variant gene sympk associated colon cancer risk odds ratio risk allele frequency allele african americans compared europeans asians amerindians genomes project addition variant previously identified fine mapping gwas region confirmed strongly associated crc african american replication set variant originally reported europeans association crc borderline significance hispanic population gwas crc cases controls three datasets combined odds ratio risk allele confidence interval study highlights importance conducting gwas studies diverse ancestry populations new heritability sporadic colorectal cancer fully explained known genetic risk variants genome wide association studies african americans help identifying ethnic specific risk variants fine mapping known susceptibility loci study authors identified novel risk variant colon cancer african americans results highlight importance conducting genome wide association studies diverse ancestry populations
genome wide association studies meta analyses implicated increased risk developing alzheimer diseases associated abca apoe bin cass cdap celf clu dsg epha fermt hla drb hla drb inppd mefc msaa msae msae nme picalm pld ptkb rin slca sorl zcwpw genes study assessed whether single nucleotide polymorphisms snps within associated genes linked cognitive aging independently complex interactions older taiwanese population also analyzed interactions lifestyle genes influencing cognitive aging total taiwanese subjects aged years taiwan biobank analyzed mini mental state examination mmse scores performed subjects evaluate cognitive functions snps tested study association cass cognitive aging persisted significantly bonferroni correction data also showed nominal association cognitive aging snps six key associated genes including epha fermt mefc pld rin slca similar additionally found interactions among cass epha fermt mefc slca cognitive aging similar moreover analysis suggested interactions slca mefc lifestyle alcohol consumption smoking status physical activity social support cognitive aging similar study indicates associated genes may contribute risk cognitive aging independently well genegene gene lifestyle interactions
geocell effective type geosynthetics improving performance reinforced soil foundations due provision lateral confinement infill soil research order study bearing pressure settlement response geocell reinforced sand reduced scale physical model developed geocells various geometrical dimensions height pocket size width produced woven geotextile used reinforce sand bed strip footing model loaded monotonically ultimate failure level influence geocell geometrical properties improvement bearing capacity settlement footing described results show increasing height decreasing pocket size geocell beneficial effect geocell reinforcement increases substantially highest geocell used tests settlement level improvement bearing capacity percentage reduction footing settlement obtained respectively optimum width geocell determined five times foundation width beyond improvement effect negligible also concluded substituting single layer geocell reinforcement half height quarter height geocell layers results decrease ultimate bearing capacity respectively sharif university technology rights reserved
geogrids geotextiles used routinely stabilize weak subgrade soils road construction typical subgrade stabilization applications temporary haul roads unpaved low volume roads also include paved roads built poorer foundation materials full scale test sections constructed trafficked monitored compare relative operational performance geosynthetics used subgrade stabilization well determine material properties related performance unpaved test sections constructed using twelve geosynthetics consisting variety geogrids geotextiles multiple control test sections also built evaluate effect subgrade strength base course thickness presence geosynthetic performance even though geotextile materials used study showed good performance subgrade stabilization material properties associated performance difficult establish due limited number test sections lack relevant tests properly characterize types materials application using longitudinal rut primary indicator performance determined linear regression analysis stiffness geogrid junctions cross machine direction correlated best performance application conditions using knowledge design equation associated giroud han method calibrated make geogrid junction stiffness cross machine direction primary property geosynthetic thereby replacing geogrid aperture stability modulus calibration verification method described herein elsevier ltd rights reserved
geomembrane tubes sometimes stacked layers form higher flood control dykes types geotechnical structures study analytical solution two layer stacked geomembrane tubes proposed evaluated using large scale laboratory model tests geometries three geomembrane tube models width length respectively cross sections two layer geomembrane tubes obtained analytical solutions agree well obtained model tests tensile forces measured model tests scattered show trend similar indicated analytical solutions parametric studies also carried investigate major factors influence design geomembrane tubes several charts also produced design two layer impermeable geomembrane tubes resting rigid foundation
geosynthetic reinforced soil grs widely used infrastructure projects retaining wall road railway subgrade technical economical reasons despite worldwide usage basic mechanism reinforcement remains obscure owing discontinuous heterogeneous nature instead layered planar geosynthetic sheets soil wrapped entirely geosynthetic containers soilbags improves bearing capacity contains dilatancy soil gain insights soilbag reinforcement mechanisms facilitate development soilbag constitutive relation authors numerically investigated micromechanical behavior grs inside woven geotextile soilbag simple shear using discrete element method dem global local stress states fabric anisotropies grs investigated sustained shear global stress path first approaches critical state line grs turns soilbag compression line meanwhile local loading unloading stress paths experienced may account high damping soilbags cyclic shear reducing fabric anisotropies normal tangential force chains suggest greater confinement lateral sides geotextile container simple shear new findings stress states fabric anisotropies wrapped grs confinement mechanism soilbag better understood
geosynthetics developing rapidly civil engineering water project transportation engineering fields recent years due advantages lightweight good continuity easy construction excellent tensile anti ripping strength good resistance chemicals microorganism development specific classification application geosynthetics depicted paper
geotextile tubes made woven geotextile materials widely applied dewater waste sludge digested bio solids sewage sludge dredged materials industrial solid wastes fly ash coal slurry however dewatering process single geotextile tubes time consuming two methods accelerate dewatering process slurry geosynthetic tubes studied using laboratory model tests first method stack one tube top another use weight top tube preload bottom one second method vacuum method proposed paper use vacuum pressure consolidate slurry geosynthetic tube thick woven polypropylene geosynthetic sheet selected geotextile tubes deformation pore water pressure tensile forces monitored model tests time presented analysed paper properties soil consolidation also measured compared model test data showed vacuum method resulted lower water content higher deformation rate two layer stacking geotextile tube method compared stacking method vacuum method could reduce risk geotextile sheet explosion
geotextiles used control soil losses civil engineering effects geotextiles runoff soil erosion documented however conditions studied date limited insufficient optimization selection application geotextiles sites result systematic studies various rainfall intensities still required study four geotextiles coir blanket mixed coir straw blanket mcsb straw blanket nonwoven fabric bare control group examined simulated rainfall events four rainfall intensities simulated min plots used experiment long wide deep slope gradient tested soil sandy loam primary soil type northern china results show geotextiles effective soil loss control runoff control especially case stronger rainfall events effectivenesses geotextiles reducing runoff soil erosion decrease increasing rainfall intensity geotextiles effective moderate rainfall intensity levels effective geotextile reducing runoff reduces soil loss rainfall intensity level natural geotextiles reduce runoff soil erosion runoff control sbs effective mcsb followed cbs soil erosion control cbs effective followed mcsbs sbs
given nonlinear infinite resistive network operating point determined approximating network finite networks obtained shorting together various infinite sets nodes taking limit nodal potential functions finite networks initially taking completion node set infinite network metric given resistances limit points obtained represent generalized ends call terminals infinite network terminals shorted together obtain generalized kind node special case node operating point involve kirchhoff current law holding nodes current terminals studied give existence bounds operating point also nodal potential function continuous nodes existence derived said approximations
given planar point set sampled object boundary process approximating original shape called curve reconstruction paper novel non parametric curve reconstruction algorithm based delaunay triangulation proposed theoretically proved proposed method reconstructs original curve epsilon sampling starting initial delaunay seed edge algorithm proceeds finding appropriate neighbouring point adding edge experimental results show proposed algorithm capable reconstructing curves different features like sharp corners outliers multiple objects objects holes etc proposed method also works open curves based study users paper also discusses application proposed algorithm reconstructing hand drawn skip stroke sketches useful various sketch based interfaces
given globalization construction industry increasing numbers expatriate construction professionals excps work practices living environment different home host countries often induce stress excps cause underperformance reduce intention stay expatriates study aims investigate interactions among stressors stress performance intention stay excps development stressors stress performance outcome model questionnaire survey purposive sampling conducted research results show work home conflict organizational centralization heavy workload affect excps overall performance intention stay indirectly vicious cycle emotional physical stress poor transportation exacerbates excps physical stress language fluency relieves physical stress impairs overall performance reducing intention stay poor transportation directly reduces excps intention stay recommendations including flexible work schedules stress management programs made study results enhance current understanding complicated stress expatriate management excps cross cultural context american society civil engineers
given importance appropriate diagnosis appropriate assessment cutaneous symptoms treatment atopic dermatitis basics treatment guideline composed investigation countermeasures causes exacerbating factors correction skin dysfunctions skin care pharmacotherapy three mainstays based disease concept atopic dermatitis inflammatory cutaneous disease eczema atopic diathesis multi factorial onset aggravation accompanied skin dysfunctions three points equally important appropriately combined accordance symptoms patient treatment important transmit etiological pathological physiological therapeutic information patient build favorable partnership patient family may fully understand treatment guideline discusses chiefly basic therapy relation treatment disease goal treatment enable patients lead uninterrupted social life control cutaneous symptoms quality life qol may meet satisfactory level basics treatment discussed guideline based guidelines treatment atopic dermatitis prepared health labour sciences research guidelines management atopic dermatitis adgl prepared atopic dermatitis guidelines advisory committee japanese society allergology principle guidelines treatment atopic dermatitis summarized japanese guideline diagnosis treatment allergic disease together allergic diseases copyright japanese society allergology production hosting elsevier
given lack active nurses industrialized countries throughout world combination demographic changes utmost importance protect nurses well prevent psychological distress strong association premature occupational leave aim study investigate effects quality leadership social support work well psychological distress nurses determine whether nurses overcommitment mediates relationship abovementioned determinants outcomes cross sectional survey design used gather data study utilized part database nurses early exit study total nurses covering nurse qualifications working hospitals nursing homes home care institutions european countries filled questionnaire response rate model variables job satisfaction satisfaction salary positive affectivity personal burnout negative affectivity quality leadership social support immediate supervisor social support near colleagues overcommitment psychometrically sound valid reliable measures used outcomes testing structural equation mediation model indicated respectively positive negative influences leadership quality social support supervisor colleagues nurses wellbeing psychological distress partially mediated reduced nurses overcommitment social work environment highly important relation nurses well psychological distress
glaciers changes important indicator global warming interpretation satellite images offers good source information monitoring important select areas interest detection glaciers bodies particular capture also part covered debris open issue remote sensing glaciers use enhancing features physical meaning provide coarse segmentation image lys glacier belonging monte rosa district alps image data correspond electromagnetic sensing sunlight reflected band visible red spectral range two infrared bands operated thematic mapper sensor aboard landsat satellite clear sunny days international association mathematics computers simulation imacs published elsevier rights reserved
glass fiber reinforced composite materials finding numerous applications many engineering domestic fields due excellent mechanical properties corrosion resistance among machining processes used drilling one important processes mainly used joining composite structures maintaining proper surface roughness drilled holes important controlled present work prediction surface roughness drilling composite materials carried using fuzzy logic recent years fuzzy logic artificial intelligence used manufacturing engineering modeling monitoring orthogonal array used experimentation fuzzy rule based model developed predict surface roughness drilling glass fiber reinforced plastic gfrp composites good agreement observed model results experimental values analysis experimental results carried using pareto analysis variance pareto anova anova presented detail
glass photonics widespread everyday objects around high tech specialized devices among different technologies sol gel synthesis allows nanoscale materials engineering exploiting unique structures transparent glass ceramics tailor optical electromagnetic properties boost photon management yield briefly discuss state technology show choice sol gel synthesis method brings advantage process versatility regarding materials composition ease implementation context present tin dioxide silica sno sio glass ceramic waveguides activated europium ions focus photorefractive properties system photoluminescence properties already discussed papers presented bibliography main findings include high photosensitivity sol gel sno sio glass ceramic waveguides ultraviolet induced refractive index change delta similar easy fabrication process low propagation losses make glass ceramic interesting photonic material smart optical applications
glial cell line derived neurotrophic factor gdnf plays important roles protecting damaged dying dopamine neurons animal models parkinson disease study determine effect mechanisms gdnf apoptosis neurons hydroxydopamine ohda induced parkinson disease model rats healthy male sprague dawley rats randomly divided six groups ohda used establish rat model tyrosine hydroxylase immunohistochemistry used assess neuron loss ohda lesioned rats tunel western blot used identify effects mechanisms gdnf rat model numbers positive neurons ohda injected lesioned substantia nigra decreased significantly compared sham group gdnf treatment effectively ameliorated apoptosis neuronal cells induced ohda addition gdnf significantly increased serine protein kinase akt glycogen synthase kinase beta gsk beta phosphorylation induced ohda contrast application triciribine reversed roles gdnf models results implicated anti apoptosis effects gdnf neurons might mediated pik akt gsk beta pathway therefore gdnf may promising agent treatment
glioblastoma multiforme gbm malignant brain tumor limited therapeutic options temozolomide tmz novel cytotoxic agent used first line chemotherapy gbm however individual cells isolated surgical resection show treatment resistance thus inducing poor prognosis using hiseq sequencing bioinformatics methods identified lncrnas showing different expression levels tmz resistant non resistant patients qpcr performed tissues serum samples lncrna malat finally identified show considerable discriminating potential identify responding patients non responding patients moreover high serum malat expression associated poor chemoresponse survival gbm patients receiving tmz treatment subsequently tmz resistant cell lines established cck assay showed lncrna malat knockdown significantly reversed tmz resistance gbm cells gain loss function experiments revealed mir downregulated malat interaction reciprocal effects besides thymidylate synthase mrna identified direct target mir lncrna malat inhibition sensitized tmz resistant cells regulating mir downregulating expression hand malat overexpression promoted resistance suppressing mir promoting expression conclusion integrated approach demonstrates enhanced expression lncrna malat confers potent poor therapeutic efficacy inhibition malat levels could future direction develop novel therapeutic strategy overcome tmz resistance gbm patients
global existence theorems large data hyperbolic fluid models often restrictions size relaxation parameter depending size initial data therefore leave general question well posedness large data open note show blow results corresponding model problems underline complexity question hence also show strength global existence theorems small parameters elsevier ltd rights reserved
global navigation satellite system gnss positioning technology employed dynamic monitoring long span bridges recent years however difficulties meet higher accuracy requirements dynamic monitoring small medium span bridges due presence measurement noise multipath cycle slips ionosphere delay orbital errors etc verify feasibility using current gnss technology monitor bridges series monitoring experiments carried wilford suspension bridge nottingham gnss triaxial accelerometer three gnss data processing modes real time kinematic rtk network rtk post processing kinematic ppk considered innovative multimode adaptive filtering maf combining adaptive filter chebyshev highpass filter used identify dynamic displacements bridge multimode gnss data validate gnss results dynamic displacements also computed double integration accelerometer measured accelerations differences displacements gnss accelerometer results obtained standard deviation mean deviation differences less good enough monitoring purposes modal frequencies bridge accurately identified gnss measurements successfully validated accelerometer data using multimode gnss data proposed map algorithm sub millimeter level accuracy gnss used monitor vibration response small medium span bridges well long span bridges authors published elsevier ltd open access article license
globally nationally locally men violence women endemic social problem enduring human rights issue within societies cultures challenging attitudes condone violence individual community level key priority prevention paper brings together findings two separate studies based children young people understandings men violence women studies located glasgow scotland used qualitative methods explore children young people views men violence women two studies conducted nearly ten years apart involved children aged young people aged despite differences age interval remarkable similarities identified within studies centring around children young people normalisation men violence women paper presents discussion three key themes identified studies construction men violence gender roles naturalisation difference normalisation men violence studies techniques normalisation employed participants minimise seriousness violence significance victims findings clearly illustrate widespread justification gendered violence boys girls thus development implementation domestic violence abuse education programmes need take account gender differences targeting boys attitudes fails acknowledge important component reducing domestic violence abuse internalisation patriarchal norms girls women
glucocorticoids gcs control essential metabolic processes virtually every cell body play vital role development fetal tissues organ systems biological actions gcs mediated via glucocorticoid receptors grs cytoplasmic transcription factors regulate transcription genes involved placental fetal growth development several experimental studies demonstrated fetal exposure high maternal levels early gestation associated adverse fetal outcomes including low birthweight intrauterine growth restriction anatomical structural abnormalities may increase risk cardiovascular metabolic neuroendocrine disorders adulthood response fetus gcs dependent gender female fetuses becoming hypersensitive changes levels whereas male fetuses develop resistance environment high maternal gcs paper review function physiological pathological effects gcs fetal development propose induced changes placental structure function including alterations expression mrna protein levels may play role inhibiting utero fetal growth
goal understanding process interactants make inferences others objectives conversation previous research examined goal understanding without concern timing goal pursuit accordingly experiment examined timing pursuers efficiency communicative behavior employed reach goal results indicated timing modified relationship pursuers efficiency detectors accuracy lesser extent detectors certainty efficiency positively correlated accuracy initial minute minute interaction subsequent minutes
goat production important agricultural activity jordan country one poorest countries world terms water scarcity provision sufficient quantity good quality drinking water important goats maintain feed intake production study aimed evaluate seasonal availability quality goats drinking water sources accessibility utilization different zones karak governorate southern jordan data collection methods comprised interviews purposively selected farmers quality assessment water sources provision drinking water considered one major constraints goat production particularly dry season long travel distances water sources waiting time watering points high fuel labor costs key reasons associated problem values water quality parameters within acceptable limits guidelines livestock drinking exception iron showed slightly elevated concentration one borehole source findings show water shortage important problem leading consequences goat keepers alleviate water shortage constraint view depleted groundwater sources alternative water sources reasonable distance tapped monitored water quality efficient use rainwater harvesting systems study area recommended
graph based semi supervised learning ssl performs well hyperspectral image classification small amount labeled samples drawn lot attention past years key step graph based ssl construct good graph represent original data structures among existing graph construction methods sparse representation based methods shown impressive performance graph based ssl however based methods fail take consideration class structure data ssl obtain probabilistic class structure implies probabilistic relationship sample class whole data utilizing small amount labeled samples class structure information help model yield discriminative coefficients motivates exploit class structure information order learn discriminative graph paper present discriminative graph construction method called probabilistic class structure regularized sparse representation pcssr approach incorporating class structure information model pcssr learn discriminative graph data class structure regularization developed make use probabilistic class structure therefore improve discriminability graph formulate problem constrained sparsity minimization problem solve alternating direction method adaptive penalty admap experimental results hyperion aviris hyperspectral data show method outperforms state art elsevier ltd rights reserved
graphene graphene like two dimensional materials attracted much attention due extraordinary electronic optical properties accommodate large potential optoelectronic applications photodetection however although much progress made many challenges exist fundamental practical aspects hindering graphene graphene like materials photodetector photonic optoelectronic applications review recent progress photodetection based graphene graphene like materials start summary important physical mechanisms including photoelectric photo thermoelectric photo bolometric regimes methodology level discussions given viewpoints state art designs device geometry materials worth emphasizing emerging photodetection photodetectors based graphene like materials metal chalcogenide nanosheets reviewed systematically finally conclude review brief discussion remaining challenges photodetection two dimensional photonics optoelectronics poe note complete understandings materials poe may inspire solar energy conversion new applications
graphic processing unit gpu proved efficient processor field conventional computations dramatic acceleration achieved earlier work different database operations gpus part conventional database languages like sql gpus designed geometric primitive visualization also used execute database operations efficiently using inherent pipelining parallelism multi threaded architecture vector processing functionality gpus along single instruction multiple data simd capabilities evaluate semi linear queries based attributes efforts required database administrators learn languages like cuda change modules order provide aid libraries present sql reduced research work focuses mainly developing system enhance execution speed select queries effective would comparison traditional methods work intends provide clear portrayal gpu hardware used query execution area relational databases future algorithms implemented databases consisting nearly million records aid programmable gpu existing results suggests using gpu processor significantly improve execution database operations optimized cpu based implementation
graphics processing unit gpu significantly increased computing capacity state art high performance computing systems paper presents novel gpu acceleration approach transient stability constrained optimal power flow tscopf one computational challenging tasks large scale power system applications enabled revealed two level decomposition parallelism reduced space interior point method gpus serve plug andplay coprocessors time consuming linear algebra operations tscopf solving enhanced multi gpu processing mixed precision iterative refinement technique efficiency solving tscopf greatly improved without redesigning reimplementing existing algorithm framework numerical studies based series test cases buses indicate effectiveness proposed gpu based approach large scale tscopf problems
graphs considered one best studied data structures discrete mathematics computer science hence data mining graphs become quite popular past years problem finding frequent itemsets conventional data mining transactional databases thus transformed discovery subgraphs frequently occur graph dataset containing either single graph multiple graphs existing algorithms field frequent subgraph discovery adopts apriori approach based generation candidate set test approach problem approach costlier candidate set generation particularly exist number large subgraphs research goals frequent subgraph discovery evolve mechanisms effectively generate candidate subgraphs excluding duplicates mechanisms find best processing techniques generate necessary candidate subgraphs order discover useful desired frequent subgraphs paper two phase approach proposed integrating apriori algorithm graphs frequent subgraph tree discover frequent subgraphs graph datasets
great investment made design installation stormwater control measures scms substantial research investment made optimise performance scms however installed scms often suffer lack maintenance even outright neglect key maintenance needs wet ponds constructed stormwater wetlands bioretention infiltration practices permeable pavement swales rainwater harvesting systems reviewed many tasks cleaning pre treatment areas preservation infiltration surfaces common maintenance themes among scms consequences lacking maintenance illustrated mainly insufficient function failure probable reasons neglect include insufficient communication unclear responsibilities lack knowledge financial barriers decentralised measures future designs research maintenance lack thereof considered assessing performance scms conservatively including safety factors may prevent consequences maintenance requiring regular inspection may help enforce sufficient maintenance
greedy algorithms important class algorithms teaching greedy algorithms complex task ensuring students design greedy algorithms new problems also complex built guided discovery based greedy algorithm tutor gatutor teach process designing greedy algorithms gatutor guides student discover greedy algorithm well known problems asking two important questions satisfying condition step selection criterion next item result students learn algorithms given problems also process designing greedy algorithms new problems conducted study compare greedy algorithm design abilities students trained gatutor versus worked traditional algorithm visualizations results indicate students worked gatutor performed better designing greedy algorithm new problem students also said confidence greedy algorithm design increased gatutor
greedy forward technique data routing wireless sensor networks wsns data packets forwarded node geographically closer destination node two main concerns found routing algorithms based technique first requires sensor nodes know physical location second kind algorithm work cases node located network hole node neighbor closer destination node work propose new greedy forward algorithm used routing protocols wsns require localization nodes also able deal nodes located near network holes differently current greedy forward algorithms approach uses received signal strength indicator rssi exchanged packets based observation propose rssr received signal strength routing algorithm two variants rssr election rssr selection rssr election next hop dynamically elected packets required routing task rssr selection neighbors exchange packets rssi information next hop packet selected routing table present novel technique dealing network holes even physical location nodes unknown technique improves reliability applicability proposed schemes wsn scenarios results indicate clearly proposed algorithms benefits greedy forward algorithm better performance better packet delivery rate without requiring position information published elsevier inc
green building becoming main trend current construction industry due main characteristics energy saving low carbon emission environmental protection exist evaluation systems green residential districts little consideration social humanity demand based methods social impact assessment social life cycle assessment considering chinese situation evaluation framework green residential districts view social humanity demand established series indexes included framework evaluation program developed make evaluation convenient end case study carried verify effectiveness proposed framework developed program
green building rapidly becoming strong momentum construction industry recognizing many negative environmental issues problems potential social economical benefits green building stakeholders including architect contractor engineers etc need collaborate successfully complete integrated green design construction eventually achieve goals sustainability construction since many negative environmental issues problems well many opportunities important develop integrated construction process icp help stakeholders successfully implement green building strategies technologies construction phase project development thus study develops icp including goals green construction processes step step procedure roles responsibilities three main stakeholders architect contractor subcontractor help stakeholder achieve sustainability construction phase published elsevier ltd
green building rating system outlines many requirements considered order building certified one however rating tools failed truly addressing acoustical aspect turn deteriorates acoustical quality green buildings preliminary stage study objective assess acoustical performance three green office buildings malaysia comparison selected standard acceptability criteria four spaces containing meeting rooms open plan offices selected green building subjects assessments limited selected acoustical parameters background noise level noise criteria reverberation time speech transmission index background noise levels found within acceptable criteria range despite meeting rooms exceeded maximum recommended level however noise criteria ratings found spaces acceptable noise criteria reverberation times data varied satisfactory unacceptable nonetheless background noise noise criteria reverberation time data collected found unbiased volume space speech transmission indexes found ample within good fair speech intelligibility range still maintaining normal tendency decreasing distance
green buildings achieved rapid development past two decades yet research efforts risk management green building projects still limited study aims identify evaluate risk factors green commercial building projects singapore compare risk criticalities traditional counterparts propose mitigation measures tackle risk factors achieve goals comprehensive literature review structured interviews carried questionnaire survey conducted singapore based construction companies survey results showed top five critical risk factors green commercial building projects inflation currency interest rate volatility worsened import green materials durability green materials damages caused human error shortage green materials results also showed green commercial building projects faced risks design change poor construction quality less criticality traditional counterparts adoptions green ideas materials technologies posed additional risks green commercial building projects additionally seven widely used risk mitigation measures also proposed study elsevier ltd rights reserved
green construction conserve resources reduce negative impact construction activities environment maximum extent scientific management technological progress premise ensuring quality safety basic requirements recent years accompanied rapid development construction industry considerable proportion energy resources particularly high carbon materials consumed construction activities emitting mass greenhouse gases damaging impact environment especially mega public projects therefore green sustainable perspective actions control carbon dioxide emissions construction industry imperative case emissions reduction considered beforehand bid evaluation stage contractors guided bid evaluation indicators therefore improve construction schemes enabling construction phase green energy saving sustainable bid evaluation indicators serve guiding effect contractors given emissions rarely given sufficient consideration traditional bid evaluation study conducts systematic analysis identify major sources construction phase attempts develop conceptual computational model terms emission linguistic group decision making framework bid evaluation mega public projects considering emissions reduction developed framework entropy relative entropy standard deviation method weighted aggregation operators applied determine indicator weights expert weights information aggregation bid evaluation decision making finally scenario comparison proposed linguistic group decision making bid evaluation framework traditional framework made case study scientific basis reliability new framework validated establishment framework enrich decision making methods construction management field provide meaningful reference owners choose qualified contractors spur contractors improve construction schemes enabling construction phase green energy saving sustainable elsevier ltd rights reserved
green real estate development one measures implemented reduce negative impacts building industry environment society economy however lack systematic review large number studies critical future endeavor paper reviews existing body knowledge related green development first common research themes green real estate development identified including concept measure business result connotation denotation green real estate development introduced four dimensions third stakeholders green real estate development benefits costs expatiated realize green real estate development current weakness analyzed various aspects found existing studies mainly focus environmental aspect green building dimensions sustainability green building especially social sustainability largely overlooked future research opportunities identified innovation evaluation systems integration planning design frameworks management mechanisms financing modes future proofing elsevier ltd rights reserved
green roofs alleviate environmental impacts reduced green areas resulting rigorous urban developments taiwan hot crowded urban environment green roofs indicative green buildings rooftop plants must able withstand harsh natural environmental conditions coastal vegetation high level tolerance therefore study selected seashore coastal region seashore vegetation landscape scenic features well drought wind temperature resistance characteristics materials green roof based records analysis vegetation characteristics provided flora vegetation taiwan study selected coastal hilly plants well coastal beach herbaceous plants plant species green roofs taiwan reinforced concrete flat roof structure selected designed demonstration site present coastal vegetation rooftop garden
green tea green tea extracts gte often incorporated diet intended weight reduction although information efficacy obese individuals insufficient present study designed follow effect defined standardized gte mice obesity induced monosodium glutamate obese mice fed gte supplemented diet three dosage regimens day day intake gte diet day intake gte diet information body weight food intake oxidation stress parameters blood antioxidant enzymes activity liver small intestine obtained high doses gte decreased specific activities glutathione reductase catalase increased concentrations malondialdehyde blood specific activities antioxidant enzymes liver small intestine altered gte treatment except decrease nad quinone oxidoreductase activity results showed gte affect average body weight markedly improve antioxidant status glutamate induced obese mice moreover intake high doses gte made antioxidant defense obese animals even worse
green vehicles electric vehicles evs getting noteworthy popularity among consumers worldwide purpose paper establish evs feasible long term solution future technology vehicle industry decrease current dependency fossil fuels also decrease greenhouse gas ghg emissions part long term benefits adoption evs gives environmentally friendly innovation society despite positive environmental implications total number evs usage still inadequate one major causes insubstantial adoption evs largely dependent perceptions consumers regarding evs however particular research study offers inclusive outline existing hurdles consumer adoption evs well framework theoretical standpoints developed adoption behaviour addition considering consumer intentions direction evs particular study researcher found literature regarding adoption tried address diffusion method evs whereas study highlights consumer innovations provides wide insight consumer emotions overlook major aspect consumer evs adoption research theme particular literature implemented order better understand consumers emotions behaviour towards adoption evs scholars stated possible cause recent developments within technological adoption part assist standard upcoming developments last years knowledge regarding problems surrounding adoption diffusion evs gained less attention study expands line research focusing making chance developing theoretical frameworks terms adding emotions psychological perspective consumer behaviour ethics considered copyright john wiley sons ltd
greenhouse gas emissions transport sector significantly reduced replacing fossil based fuels green alternatives various alternative fuel concepts developed differing used sustainable feedstock synthesis technology final fuel characteristics whether fuels succeed market depend fuel net production costs expected cost reduction potentials political intention mitigate climate change results previous studies techno economic assessment alternative fuels difficult compare due significant differences applied methodology level detail key assumptions terms economic factors market prices work standardized methodology techno economic analysis fuel production processes presented exemplarily applied sustainable fuels fischer tropsch synthesis methodology adapted best practice approach chemical industry consists three main steps literature survey feasible production designs flowsheet simulation techno economic assessment house software tool tepet techno economic process evaluation tool shown standardized approach enables qualitative quantitative statements regarding technical economic feasibility fuel synthesis concepts including identification appropriate fuel production concept due predefined framework conditions results case study green fuels reveal biomass liquid btl concepts lowest production costs high electricity costs whereas power liquid ptl power biomass liquid pbtl concepts superior low electricity prices fuel production costs range sic estimated elsevier ltd rights reserved
greenhouse gases gags one main reasons behind earth warming iran majority power plants utilize fossil fuels generating electricity also production gags fossil fuels high gas production system gps found good candidate lowering amount gags produced therefore study optimal size operation different gpss used combined cool heat power system investigated particle swarm optimization algorithm used optimization results show sewage sludge gps reciprocating engine lowest payback period addition highest pollution cost condition selling electricity electrical network
grid computing high performance distributed computing platform solve complex large scale scientific problems consists heterogeneous computing resources connected network across dynamic geographically distributed organisations create distributed high performance computing infrastructure job scheduling computational grid known complete problem owing problem complexity intractable nature problem problem could solved using heuristic algorithms types algorithms ability find near optimal solution reasonable time rather optimal solution long processing time primary objective scheduling minimise makespan system paper improved cuckoo search ics optimisation method proposed scheduling user jobs available resources various performance metrics optimised attention focused improvement computational grid performance terms makespan completion time study reveals proposed ics algorithm provides better results comparison cuckoo search simulated annealing
grid voltage feedforward extensively used controlling grid connected converters however conventional voltage feedforward control reduces stability margins converter connected high impedance grid effect mechanism voltage feedforward grid connected converter control high inductive conditions grid impedance clearly explained study using equivalent transformations control block diagrams results show delay produced digital control root cause effect improved voltage feedforward strategy bandpass filter bpf introduced feedforward path proposed strengthen converter robust stability grid impedance variations selection method bpf bandwidth also provided considering tradeoff response speed grid voltage sag system robust stability converter work stably wide range grid impedance proposed approach simulation experimental results fully verify effectiveness bpf based voltage feedforward strategy
grounded dual risk biosocial perspective developmental psychopathology study examined role higher vagal suppression providing young adolescents protection four parenting stressors expected lower vagal suppression would increase youth vulnerability deleterious effects parenting stressors depressive symptoms examined central marker socioemotional difficulties early adolescence four parenting stressors examined interparental hostility maternal use harsh discipline maternal inconsistent discipline maternal psychological control participants young adolescents grade mothers greater vagal suppression provided protection lower depressive symptoms interparental hostility harsh discipline maternal psychological control boys girls elsevier inc rights reserved
grounded tripartite model perfectionism previous empirical support current study explored qualitatively different types perfectionists well total college students responded measures perfectionism conscientiousness neuroticism well latent profile analysis identified three distinct latent classes perfectionists adaptive maladaptive non perfectionists adaptive perfectionists exhibited highest levels presence meaning subjective happiness life satisfaction maladaptive perfectionists showed highest levels search meaning findings call attention value exploring heterogeneity perfectionists well elsevier ltd rights reserved
groundwater management practices need take hydrogeology agro climate demand groundwater account since agroclimatic zones already demarcated government india would aid policy makers understand status groundwater recharge discharge agroclimatic zone however developing effective policies manage groundwater agroclimatic zone state levels constrained due paucity temporal data information launch gravity recovery climate experiment grace mission possible obtain frequent data broad spatial scales use examine past trends rain induced recharge groundwater use study grace data used estimate changes monthly total water storage tws groundwater storage different agroclimatic zones rajasthan india furthermore long term annual seasonal groundwater storage trends state estimated using grace data trends compared rainfall data methodology based grace data found useful detecting large scale trends groundwater storage changes covering different agroclimatic zones analysis data shows groundwater storage trends depend rainfall previous years therefore antecedent moisture conditions overall study indicates suitable groundwater recharge methods sites identified state potential achieve groundwater recharge currently occurring thus enhancing availability water irrigated agriculture
group signature scheme method allowing member group sign message anonymously behalf group group administrator charge adding group members ability reveal original signer event disputes based controlled quantum teleportation three particle entangled states propose new quantum group signature scheme designated receiver security analysis proves proposed scheme possesses characteristics group signature resists usual attacks compared previous proposed schemes scheme follows security definition group signature fully meets basic requirements
growing evidence epidemiological studies strongly suggests maternal infection risk factor psychiatric disorders including bipolar disorder schizophrenia autism animal studies support association demonstrate maternal immune activation mia changes brain morphology inflammatory cytokines adult offspring evidence changes inflammatory cytokines also demonstrated human post mortem brain peripheral blood studies subjects psychiatric disorders perspective briefly highlights convincing evidence epidemiological preclinical human pathological studies support role mia major psychiatric disorders better understanding link mia brain development psychiatric disorders lead development novel immunomodulatory interventions individuals risk psychiatric disorders ibro published elsevier ltd rights reserved
gut microbiota patients parkinson disease healthy volunteers analyzed method high throughput rrna sequencing bacterial genomes patients parkinson diseases changes content genera species microorganisms revealed reduced content dorea bacteroides prevotella faecalibacterium bacteroides massiliensis stoquefichus massiliensis bacteroides coprocola blautia glucerasea dorea longicatena bacteroides dorei bacteroides plebeus prevotella copri coprococcus eutactus ruminococcus callidus increased content christensenella catabacter lactobacillus oscillospira bifidobacterium christensenella minuta catabacter hongkongensis lactobacillus mucosae ruminococcus bromii papillibacter cinnamivorans microbiological pattern gut microflora trigger local inflammation followed aggregation alpha synuclein generation lewy bodies
gypsy name conjures wide variety images peoples minds romanticised freedom reviled antisocial behaviour roma people turns subject exotic myth virulent prejudice roma depicted romantic criminal outsiders anything thieves talented artistic people exploiting potentiality item response theory models study aims assess level consolidation positive negative stereotypes roma people italy addition investigate socio demographic covariates affect degree acceptance cliched depiction roma results suggest images representations gypsies confirm distinction nature culture persist culture one hand roma perceived free societal constrains nature hand portrayed criminals untruthful relational qualities arise societal organised condition culture distinction continues misused delegitimise minority groups especially roma elsevier ltd rights reserved
hacking improving software process trial error mode rehearsal claim made miguel escobar varela article furthers exploring similarities ways theatre makers software programmers speak crafts understanding software programming essentially creative process interest theatre scholars constantly searching modes academic discourse sensitive specificity theatre offering examples interface design study javanese theatre escobar argues creating software iterative process trial error become part methodological palette theatre scholars miguel escobar varela assistant professor theatre studies national university singapore worked theatre researcher computer programmer translator mexico netherlands indonesia singapore articles intersection digital technology theatre studies published digital scholarship humanities asian theatre journal performance research contemporary theatre review forthcoming tdr theatre research international
hadoop become widely used open source framework large scale data processing mapreduce core component hadoop programming paradigm allows massive scalability across hundreds thousands servers hadoop cluster allows processing extremely large video files image files data nodes used implementing content based image retrieval cbir algorithms hadoop compare match query images previously stored terabytes image descriptors databases work presents implementation one well known cbir algorithms called scale invariant feature transformation sift image features extraction matching using hadoop platform gives focus utilizing parallelization capabilities hadoop mapreduce enhance cbir performance decrease data input output operations leveraging partitioners combiners additionally image processing computer vision tools hadoop image processing hipi open computer vision opencv integration shown
halobetasol propionate ultra potent corticosteroid used management severe recurrent cases atopic dermatitis marketed cream formulations based synthetic surfactants often aggravate present studies investigate biocompatible pluronic lecithin organogel plo halobetasol propionate management organogels prepared aqueous titration method preliminary ternary phase studies optimized ratio surfactant phospholipon surfactant propylene glycol optimized organogel comprised surfactant surfactant ratio exhibited satisfactory morphology rheology systematic analysis employing statistical models revealed increasing concentration lecithin pluronic enhanced viscosity formulation inhibited drug release developed formulation showed enhanced drug retention skin compared marketed cream exvivo permeation studies across rodent skin increased deeper layer permeation plo confirmed confocal microscopy using fluorescent marker histopathological evaluation excised skin treated rats revealed non irritating nature plo present studies indicate possibility non irritating biocompatible dosage form potent steroids increase drug permeation aggravate also expected alleviate xerosis potential dose reduction drug
haloferax alexandrinus strain jcm ifo extreme halophilic archaeon able produce significant amounts canthaxanthin genome sequence analysed work using bioinformatics tools available expasy order look genes encoding nitrate reductase like proteins respiratory nitrate reductase nar assimilatory nitrate reductase nas ability cells reduce nitrate aerobic conditions tested enzyme charge nitrate reduction aerobic conditions nas purified characterised monomeric enzyme kda requires high salt concentration stability activity optimum value activity effectiveness different substrates electron donors cofactors inhibitors also reported high nitrite concentrations detected within culture media aerobic microaerobic cells growth main conclusion results haloarchaeon reduces nitrate aerobically thanks nas may induce denitrification anaerobic microaerobic conditions using nitrate electron acceptor study sheds light role played haloarchaea biogeochemical cycle nitrogen paying special attention nitrate reduction processes besides provides useful information future attempts microecological biotechnological implications haloarchaeal nitrate reductases
hand injuries account sports injuries common contact sports sports high risk falling appropriate management requires knowledge type injury demands sport position competitive level athlete future athletic demands expectations role rehabilitation protective splints return play management athlete requires aggressive expedient diagnostic intervention treatment article describes ligamentous injuries thumb including thumb carpometacarpal dislocations thumb metacarpophalangeal dislocations collateral ligament injuries interphalangeal dislocations evaluation treatment outcomes
hardware based image processing offers speed convenience found software centric approaches show theoretically periodic array dipole coupled elliptical nanomagnets delineated piezoelectric substrate act dynamical system specific image processing functions nanomagnet two stable magnetization states encode pixel color black white image containing black white pixels first converted voltage states mapped magnetization states nanomagnet array magneto tunneling junctions mtjs mtjs employed read processed pixel colors later dipole interaction nanomagnets implements specific image processing tasks noise reduction edge enhancement detection functions triggered applying global strain nanomagnets voltage dropped across piezoelectric substrate image containing arbitrary number black white pixels processed nanoseconds low energy cost
harvested rainwater alternative water source buildings especially non potable uses irrigation toilet flushing rainwater harvesting perceived sustainable design approach limited information environmental economic performance technology address literature gap life cycle assessment life cycle costing tools applied dormitory could potentially use harvested rainwater flush toilets irrigate lawn five scenarios modeled including new versus renovated building irrigation versus toilet flushing water end use rainwater cisterns scenarios sized using yield spillage approach long term daily precipitation toledo energy greenhouse gas emissions calculated using economic input output life cycle assessment construction phase energy use pump gabi water wastewater treatment databases life cycle environmental impacts costs estimated compared business usual scenario water supply demands met municipally supplied potable water combined separate sanitary sewer network discovered energy greenhouse gas emission payback periods achieved almost every scenario yet cost payback periods implementing harvested rainwater found longer life time building except two scenarios using rainwater irrigation renovation project using rainwater toilet flushing new construction project two scenarios lowest cost energy greenhouse gas emission impacts among scenarios modeled reducing occupancy match toilet flushing demand increased per person impact however general per person impacts much lower person impact driving electricity use separate sewers divert stormwater runoff water bodies thereby prevent environmental problems resulting combined sewer overflows rainwater harvesting system connected separate sewers found reduce energy greenhouse gas emissions less rainwater harvesting system connected combined sewers elsevier ltd rights reserved
access right information right time remains pervasive problem operations maintenance thus hinders asset owner ability ensure facilities performance optimized typically asset managers often confronted built documentation prepared using computer aided design cad often incomplete erroneous redundant adversely impacts asset integrity productivity mind quality information contained within built electrical documentation underground railway station evaluated quantifying errors omissions contained within cost document information using cad compared development system information model sim determined retrospective sim constructed directional link three dimensional model established ensure integrity information required use sim instead cad provide engineers new medium process preparing design documentation electrical systems provides ability obtain significant productivity cost benefits empirical research presented paper provides impetus future research fertile unexplored area digital asset management infrastructure projects elsevier ltd rights reserved
hcci homogeneous charge compression ignition combustion offers high efficiency low nox particulate matter emissions however operating range hcci engines limited excessive prr pressure rise rate high load region main reason engine knock problem shown hcci combustion ignition timing retarded tdc top dead center controlling gas temperature properly addition combustion duration also needs ensured adequately egr exhaust gas recirculation gas known impacts history gas temperature objective study investigate influence egr ratio combustion characteristics computational modeling work conducted using single zone code detailed chemical kinetics order investigate influence egr ratio engine speed contribution matrix used extract important reaction paths reaction mechanism elsevier ltd rights reserved
hcv global sequences classified genotypes several subtypes number unassigned sequences aim perform depth investigation taxonomic relationships unclassified cyhcv strain means phylogenetic analysis phylogenetic tree reconstructions performed using methods full length genomic partial hcv alignments phylogenetic analysis full length sequences revealed cyhcv clustered close root node genotype showing distant genetic relationships previously classified subtypes unclassified sequences single section analysis using sse showed distances query subtypes much higher distances within subtypes genotype recombination analysis revealed evidence intersubtype genetic mixing query references different genotype subtypes different analyses revealed cyhcv genetically divergent within genotype showing high low level clustering previous subtypes unclassified sequences identification single lineage within genotype without late branching explained genetic isolation late stage hcv epidemic spread elsevier inc rights reserved
present work aimed develop novel composite material made activated cow bone powder cbp starting material reducing chemical oxygen demand cod ammonia nitrogen palm oil mill effluent pome optimization reduction efficiency investigated using response surface methodology rsm six independent variables used optimization experiments include speed rcf contact time particle size dilution factor adsorbent dosage chemical functional groups determined using fourier transform irradiation ftir elemental composition detected using sem edx thermal decomposition investigated using thermo gravimetric analysis tga order determine effects carbonization temperature adsorbent results revealed optimal reduction cod raw pome observed rpm within particle size well dilution factor adsorbent dosage observed predicted reduction respectively cod main functional groups adsorbent sem edx analysis revealed cbp composite smooth surface high contents carbon activated cbp stable temperature profile significant weight loss conclusion cbp composite investigated characteristics high potential remediation cod raw pome elsevier ltd rights reserved
headaches extensively reported antiphospholipid syndrome aps antiphospholipid antibodies apl positive patients aim study highlight prevalence headaches among aps apl positive patients discuss association laboratory clinical imaging findings searched literature google scholar pubmed publications epidemiology pathogenesis laboratory imaging clinical findings management headaches aps apl positive patients following keywords used antiphospholipid hughes syndrome anticardiolipin lupus anticoagulant anti beta glycoprotein headache migraine tension cluster reports published included migraine commonly reported type headache aps apl positive patients thrombotic platelet dysfunction hypotheses studied uncover pathogenic role apl development headaches several studies reporting higher levels apl primary secondary aps migraineurs reached statistical significance migraine patients without clinical signs symptoms cerebral infarction rarely show positive imaging findings digital subtraction angiography shows promise demonstrating small vascular lesions otherwise detected computed tomography magnetic resonance imaging cerebral angiograms although may solitary harmless many cases deleterious effect migraine quality life aps patients prompts rapid diagnosis proper management anticoagulation trial advisable aps patients migraine many cases severe refractory migraine resolved anticoagulation therapy profile migraine headaches discussed study permits candidacy inclusion future aps classification criteria
health aspect daylight revalued recent years whereas urban congestion multistory buildings architectural design minimize daylight openings high energy performance buildings tend constrain people enjoying benefits daylight buildings urban building act established japan building standard law replaced protection life health property nation public welfare building standard law provides regulations sunlight daylighting restrictions height form buildings requirements daylight openings regulations gradually relaxed urban growth paper outlines historical changes japanese regulations standards sunlight daylighting example discusses challenges future development revision international standards sunlight daylighting especially inclusion criteria health
health systems employing physicians growing numbers implications trend poorly understood controversial use rich data centers medicare medicaid services examine effects set physician acquisitions hospital systems outpatient utilization spending find financial integration systematically produces economically large changes acquired physicians behavior less consistent effects acquiring system level published elsevier
heart disease defined abnormality heart whether cardiac dysrhythmia structural heart disease either congenital acquired heart failure occurs cardiac abnormality results inability heart pump enough blood meet body needs heart disease present without leading heart failure heart failure however consequence heart disease main areas clinician intervene improve cardiac output heart failure preload afterload myocardial contractility heart rate
heat transfer affects performance phasing internal combustion engines correlations equilibrium wall function models typically employed engine simulations predict heat transfer however many studies shown significant errors expected owing failure fundamental assumptions deriving equilibrium wall function models non equilibrium wall models provide accurate way describing near wall region cylinder flows study simultaneous high speed high resolution particle image velocimetry heat flux measurements conducted optically accessible engine experiments performed motored fired conditions two different engine speeds experimental data utilized assess performance different models predicting thermoviscous boundary layer models include commonly used heat transfer correlations equilibrium modified wall function models recently developed non equilibrium wall model found equilibrium wall function model significantly underpredicts heat flux motored fired conditions considering heat release effects boundary layer non equilibrium wall model shown able adequately capture structure dynamics momentum thermal boundary layers comparison experimental measurements demonstrating improved performance previously employed correlation functions equilibrium model
heat resistant high temperature materials used manufacture components devices systems operated high temperatures severe heat loads gas turbines used power industry traction marine aircraft engines aerospace technology etc good examples systems generally temperature increases mechanical strength materials decreases making materials tendency keep possibly low thermal weakening course operating gas turbines various kinds failures defects damages may occur components thereof particular blades predominating failures damages attributable material overheating thermal fatigue resulting loss mechanical strength paper intended present findings changes microstructure blades made nickel base alloy due high temperature material gets overheated results deterioration microstructure condition material condition presents low high temperature creep resistance component within effect occurs exposed failure damage usually resulting malfunctioning turbine sometimes aero engines fatal accident failures damages kind always need major repairs expensive
heavy traffic loading produce loss functionality pipeline networks consequential interference economic social impacts areas involved breakage consequences breakage disconnection pipelines technical economic social case sewer network failure illness epidemics might result paper protect buried pipe use three dimensional geosynthetic geocell investigated reinforce trench two series three dimensional full scale tests repeated loadings performed first test programme compares performance buried pipes installed beneath soil unreinforced planar reinforced geocell trench compaction difficulties necessitated change process compaction second installation proposed series tests understanding behaviour geocells different opening areas heights buried pipes repeated loads presented discussed observed effective reinforcement improvement backfill system achievable geocell installed backfill appropriate compaction process results indicate importance compaction level geocell installation result modified compaction process trench reinforced geocell showed superior performance delivering reduction soil surface settlement vertical diametral strain respectively compared unreinforced soil
heightened cutaneous immune surveillance atopic patients may inhibit development melanoma aim study analyse association atopy melanoma development outcome total cases melanoma healthy controls interviewed telephone standardized questionnaire atopic demographic melanoma characteristics cases matched controls important confounders age sex sunburn sensitivity hair colour number moles sunburn juvenile ever sunbed use familial melanoma melanoma outcome data disease relapse death within cases retrieved analysis showed general inverse association atopy melanoma development statistically significant history personal atopy odds ratio confidence interval value among melanoma patients atopy affect survival progression conclusion study suggests inverse association history atopy melanoma development disease progression
helicobacter pylori pylori common gastrointestinal bacterial strain closely associated incidence chronic gastritis peptic ulcers gastric mucosa associated lymphoid tissue lymphoma gastric cancer current research clinical challenge increased rate antibiotic resistance pylori led decreased pylori eradication rate article review recent pylori infection reinfection rates pylori resistance antibiotics discuss pertinent treatments pubmed literature search performed using following keywords helicobacter pylori infection reinfection antibiotic resistance bismuth proton pump inhibitors vonoprazan susceptibility quintuple therapy dual therapy probiotic prevalence pylori remained high areas despite decreasing trend pylori prevalence observed time additionally pylori reinfection rate varied different countries due socioeconomic hygienic conditions helicobacter pylori monoresistance clarithromycin metronidazole levofloxacin common countries however prevalence amoxicillin tetracycline resistance remained low pylori infection reinfection present serious challenges pylori resistance clarithromycin metronidazole levofloxacin remains high countries selection efficient regimen eradicate pylori critical currently bismuth containing quadruple therapies still achieve high eradication rates moreover susceptibility based therapies alternatives may avoid use unnecessary antibiotics novel regimens vonoprazan containing triple therapies quintuple therapies high dose dual therapies standard triple therapies probiotics require studies concerning efficiency safety treating pylori
helium cooled pebble bed hcpb blanket concept one demo demonstration power plant blanket concepts running final demo design selection paper transient analyses cooling channels carried means cfd simulations selected accidental scenarios loss coolant accident loca loss flow accident lofa ansys cfx used simulations simulation results help understand fast temperature increase time window available temperature structural material reaches design limit order able define suitable protection strategy system view later developments models heat transfer coefficients calculated cfd compared values predicted two widely used correlations turbulent pipe flows euratom published elsevier rights reserved
hepatic retransplantation surgically challenging since beginning liver transplant outcomes improved time patient survival retransplant continues significantly worse primary transplant many studies focused factors predict outcomes models developed help predict risk decision retransplant must multidisciplinary transplant team decision question much guided recipient donor factors ethical decision must made liver transplant team
hepatitis virus hcv displays restricted host species tropism humans chimpanzees susceptible infection robust immunocompetent animal model still lacking hampering mechanistic analysis virus pathogenesis immune control prophylactic vaccine development closest homolog hcv equine nonprimate hepacivirus nphv shares similar features hcv thus represents animal model study hepacivirus infections natural hosts aimed dissect equine immune responses experimental nphv infection conducted challenge experiments investigate immune protection secondary nphv infections horses injected nphv containing plasma flow cytometric analysis used monitor immune cell frequencies activation status infected horses became viremic viremia could detected two horses several weeks followed delayed seroconversion viral clearance histopathological examinations liver biopsies revealed mild periportally accentuated infiltrations lymphocytes macrophages plasma cells horses displaying subclinical signs hepatitis following viral challenge activation equine immune responses observed importantly primary nphv infection horses protected rechallenge homologous well distinct isolate minute amounts circulating virus detectable
hepatitis virus hcv global health concern vaccine available hcv polymerase responsible critical function replicating rna genome virus transitions least two conformations open closed necessary allow enzyme replicate rna study molecular dynamic simulations initiated multiple crystal structures understand free energy landscape fel explored enzyme interconverts conformations studies reveal location distinct states within fel well molecular interactions associated states specific hydrogen bonds appear play key role modulating conformational transitions knowledge essential elucidate role conformations replication may also valuable understanding basis enzyme inhibited small molecules wiley periodicals inc
hepatitis virus hcv enveloped rna virus belonging flaviviridae family infects mainly human hepatocytes causes chronic liver diseases including cirrhosis cancer hcv encodes two envelope proteins form heterodimer mediate virus entry extensively studied less done role hcv life cycle still needs elucidated developed new cell culture model hcv infection based trans complementation virus production hcv genome lacking encoding sequence efficiently rescued ectopic expression trans resulting virus designated hcv propagate packaging cells expressing results single cycle infection naive cells using hcv system explored role putative fusion peptide hcv infection interestingly found contributes hcv entry previously reported also may involved virus morphogenesis finally identified amino acid residues critical biological functions summary work provides new cell culture model studying hcv also provides insights understanding role hcv life cycle importance hepatitis virus hcv enveloped rna virus encodes two envelope proteins form heterodimeric complex mediate virus entry compared biological functions virus life cycle adequately investigated developed new cell culture model single cycle hcv infection based trans complementation hcv genome lacking encoding sequence efficiently rescued virus production ectopic expression trans new model renders unique system dissect functional domains motifs using system found putative fusion peptide multifunctional structural element contributing hcv entry morphogenesis work provided new cell culture model study hcv provides insights understanding biological roles hcv life cycle
hepatocellular carcinoma hcc common type primary liver cancer second common cause cancer deaths worldwide top three causes hcc hepatitis virus hbv hepatitis virus hcv alcoholic liver disease owing recent advances direct acting antiviral agents hcv eradicated almost patients hbv infection alcoholic liver disease expected therefore become leading causes hcc future however association alcohol consumption chronic hepatitis progression liver disease less well understood chronic hepatitis mechanisms underlying complex interaction hbv alcohol fully understood enhanced viral replication increased oxidative stress weakened immune response could play important role development hcc remains controversial whether hbv alcohol synergistically increase incidence hcc herein review currently available literature regarding interaction hbv infection alcohol consumption disease progression
herbs spices used food medicinal purposes centuries first recorded evidence use dates back ebers papyrus mentioned spices anise mustard saffron cinnamon cassia century variety secondary compounds produced plants used many fields industry food production improve taste provide vitamins macro microelements also inhibit food spoilage caused foodborne bacteria medicine treatment various diseases chemoprevention cancer therapy source natural antimicrobials treatment infectious disease pharmacology cosmetology dietary supplements result demand preservative free cosmetics reduce risk methylparaben allergies aim review present major active compounds herbs spices explore potential applications industry
present technical economical performances small scale trigeneration power plant based solid oxide fuel cells designed small residential cluster apartments energy system features natural gas solid oxide fuel cell boiler refrigerator thermal storage system compare different power plant configurations varying size fuel cell refrigeration technology satisfy chilling demand absorption mechanical chiller given ability meet power demand crucial kind applications plant performances assessed following optimal control strategy function different energy demand profiles electricity prices rated part load efficiencies energy converter optimization energy system operating strategy performed graph theory based methodology results provided terms electrical thermal efficiency operating strategy well economic saving primary energy consumption reduction pay back period considering different capital costs fuel cell elsevier ltd rights reserved
provide evidence repeated immobilization stress ris rats induces persistent increase noradrenergic activity anterior aspects anterolateral bed nucleus stria terminalis aibnst increase noradrenergic activity results enhanced synthesis reuptake norepinephrine leads decrease synaptic availability elicits augmented noradrenergic response inhibitors reuptake nris desipramine dmi antidepressant enduring depression like behavior augmentation climbing behavior seen repeatedly stressed rats following subchronic administration dmi forced swimming test fst might explained dysregulation noradrenergic transmission observed albnst taken together propose dysregulation noradrenergic transmission one described present work may represent mechanism underlying major depressive disorders mdd melancholic features humans elsevier ltd rights reserved
report novel type smart material capable specifically responding changing rate environmental signal shown example lightly cross linked syndiotactic polypropylene reacts temperature increase adapting shape change according applied heating rate general material properties used predict system failure used defined environment therefore called predictive material
hereditary angioedema hae rare serious potentially life threatening autosomal dominant condition caused low dysfunctional esterase inhibitor inh uncontrolled contact pathway activation symptoms characterized spontaneous recurrent attacks subcutaneous submucosal swellings typically involving face tongue larynx extremities genitalia bowel prevalence hae estimated without known racial differences causes psychological stress well significant socioeconomic burden early treatment prevention attacks associated better patient outcome lower socioeconomic burden new treatments better evidence base management emerging together move hospital centered patient centered care enable individualized tailored treatment approaches
hereditary angioedema hae deficiency inhibitor inh autosomal dominant disease characterized recurrent episodes potentially life threatening angioedema objective study incidence hae among patients visit emergency department year prospective observational screening study involving urban tertiary emergency centers osaka prefecture japan patients included met following criteria unexplained edema body upper airway obstruction accompanied edema anaphylaxis acute abdomen intestinal edema including ileus acute pancreatitis asthma attack inh activity level measured time emergency department admission period july june study comprised patients median age iqr years three patients newly diagnosed hae patient already diagnosed hae inh activity levels patients hae detection limit whereas non hae patients iqr normal range median level significantly lower patients hae compared without hae iqr iqr normal range three patients undiagnosed hae diagnosed hae emergency department year period patients signs symptoms suspicious hae levels inh activity measured
hereditary angioedema rare disease caused deficiency compleman esterase inhibitor regulatory protein compleman system priapism involuntary painful prolonged erection penis without sexual desire case report elucidated patient diagnosed hereditary angioedema recurrent priapism
hereditary angioedema autosomal dominant inherited disease leading oedema attacks variable severity localization predominantly caused inh deficit mutations already identified however genetic analysis brazilian cohort hae patients inh deficiency published aim perform genetic analysis inh gene serping brazilian hae patients screened whole serping coding region subjects unrelated families confirmed diagnosis hae due inh deficiency clinical diagnosis based symptoms quantitative functional analysis inh identified fifteen different mutations among eight previously described according databases found five small deletions del delg del del delga producing frameshifts leading premature stop codons seven missense mutations one nonsense mutation two intronic alterations despite small number participants study results show mutations previously identified serping gene study represents first brazilian hae cohort evaluated mutations introduces possibility perform genetic analysis case need differential diagnosis
herein examined insulin resistance insulin sensitivity beta cell activity glucose metabolism subjects antisocial personality disorder aspd whether serotonin htb receptor testosterone role energy metabolism cohort subjects belonging founder population included aspd males aged divided groups based presence heterozygous htb receptor loss function gene mutation htrb serum glucose insulin levels measured oral glucose tolerance test indices describing beta cell activity calculated body mass index bmi also determined concentrations serotonin metabolite hydroxyindoleacetic acid measured cerebrospinal fluid testosterone levels serum like state comprising high low high beta cell activity indices observed among aspd subjects without htrb allele contrast aspd htrb carrier appeared preventive pathophysiologies htrb allele testosterone predicted lower bmi independently interaction htrb testosterone lead increased insulin sensitivity among htrb carriers low testosterone levels htrb allele also predicted reduced beta cell activity enhanced glucose metabolism reduced htb receptor function low normal testosterone levels may protective obesity results observed among finnish males antisocial personality disorder limits generality elsevier ltd rights reserved
herpes zoster infection common condition elderly immunosuppression involving cellular immunity favors occurrence pain frequent complications occurs people aged years virological diagnosis typical useful diagnosis mainly based clinical data skin care essential limit cutaneous damage antiviral drugs reduce risk post herpetic neuralgia early prescribed within hours rash onset analgesia essential conducted relation evolution vaccination effective way prevent occurrence complications elderly particular post herpetic neuralgia
heterogeneous computing combining devices different architectures cpus gpus rising popularity promises increased performance combined reduced energy consumption opencl proposed standard programming systems offers functional portability however suffers poor performance portability applications must retuned every new device paper use machine learning based auto tuning address problem benchmarks run random subset tuning parameter spaces results used build machine learning based performance model model used find interesting subspaces search evaluate method using five image processing benchmarks tuning parameter space sizes using different input sizes several devices including intel haswell cpu nvidia tesla gpu amd radeon gpu compare different machine learning algorithms performance model model achieves mean relative error low able find solutions average slower best configuration cases evaluating less search space source code framework available https github com acelster autotuning
heterozygous triggering receptor expressed myeloid cells trem mutations alzheimer disease risk factor nonmutated trem dysregulation occurs brain whether trem altered prodromal remains unknown western blotting used determine levels trem similar kda iba frontal cortex trem hippocampus people died antemortem clinical diagnosis non mild cognitive impairment mild moderate severe sad immunohistochemistry defined relationship amyloid iba profiles polymerase chain reaction analysis revealed subjects carry common trem variant trem significantly upregulated sad frontal cortex stable hippocampus frontal trem mrna protein level patterns similar significantly different iba immunopositive microglia counts increased significantly frontal cortex containing plaques sad trem iba levels associated plaques tangles neuropathological criteria cognitive performance frontal cortex trem upregulation late event may play major role early pathogenesis disease elsevier inc rights reserved
high oxygen affinity hemoglobins responsible rare heterogeneous autosomic dominant genetic diseases cause pure erythrocytosis sometimes accountable hyperviscosity thrombosis hemolysis differential diagnoses must first ruled diagnosis based identification decreased possible characterization cation exchange high performance liquid chromatography capillary electrophoresis finally genetic studies responsible globin chain gene confirm mutation prognosis mainly relies decrease rate hemoglobin cooperativity impairment disease management personalized primarily depend smoking cessation physical activity phlebotomy platelet aggregation inhibitors prescriptions discussed contraindication flights high altitude conditions pregnancy nevertheless blood donation must prohibited societe nationale francaise medecine interne snfmi published elsevier masson sas rights reserved
high penetration wind energy network may introduce stability power quality problems due fluctuating nature wind increasing complexity power system paper describes novel approach voltage power control radial electrical distribution network using wind farm wind farm consists seven induction generators dfig supplying two converters feed structure dfig allows operating system conversion wide range speed variations recommended solution due capacity increase generator power twice nominal power consequently system size cost reduced another advantage system decoupled electrical network disturbances affect dfig also avoids problems coupling machine power grid node distribution network study proves method feasible simulation work carried software matlab simulink results obtained prove control suitable regulating desired power flows power network providing best voltage profile system well minimizing system transmission losses inserting wind farm electrical network
high rates relapse following substance misuse treatment highlight urgent need effective therapies although number empirical studies investigating effects mindfulness treatment substance misuse increased dramatically recent years reviews examined findings mindfulness studies thus systematic review examined methodological characteristics substantive findings studies evaluating mindfulness treatments substance misuse published review also includes first meta analysis randomized controlled trials mindfulness treatments substance misuse comprehensive bibliographic searches pubmed psyclnfo web science identified pertinent studies meta analytic results revealed significant small large effects mindfulness treatments reducing frequency severity substance misuse intensity craving psychoactive substances severity stress mindfulness treatments also effective increasing rates posttreatment abstinence cigarette smoking compared alternative treatments mindfulness treatment substance misuse promising intervention substance misuse although research needed examining mechanisms mindfulness interventions exert effects effectiveness mindfulness treatments diverse treatment settings elsevier inc rights
high definition video becoming standard clinical endoscopy state art systems medical endoscopy provide video streams high resolutions frame rates real time execution image processing tasks far trivial requiring careful algorithm design development article propose fully functional software based solution correcting radial distortion video runs real time personal computer equipped conventional graphics processing unit gpu video acquisition card system acquires video feed directly digital output endoscopic camera control unit warps frame using heterogeneous parallel computing architecture outputs result back display although target particular problem correcting geometric distortion medical endoscopy concepts framework herein described extended image processing tasks hard real time requirements show heterogeneous approach well efficient memory access patterns gpu improve performance highly memory bound algorithm leading frame rates fps
higher education ought support identification training needs industrial building information modelling bim curriculum development sustainability education fields civil engineering management cem paper proposes framework based four phase step step quality function deployment qfd application cem curriculum planning quality management framework attempts respond requests collected professionals professors order integrate bim higher education curriculum china specific focus construction management programs accredited american council construction education acce entropy method scale adapted bloom revised cognitive process employed evaluate cem curriculum qfd proposed framework successfully applied cem curriculum planning included two curriculums four main knowledge areas provided chinese cem guidelines construction cost flow construction two curriculum areas showed content focus knowledge program evaluation review technique pert planning construction optimization flow construction principles bill quantities construction consumption construction costs teaching quality management china higher education curriculum focus three aspects promote curriculum integration pedagogical design teaching resource material curriculum assessment research sheds light pedagogical shift similar context established guidelines accredited acce respect reviewing curriculum planning knowledge system perspective order meet industrial demands operational level
higher order sliding mode control algorithms second order particular become popular research area research analyzes performance optimally designed super twisting stw controllers application liquid level process problem optimal design stw controller formulated solution methodology presented performance stw controller compared performance optimally tuned pid controller study carried analytical approach simulations experiments comparison performance conclusions drawn suitability use stw controller process specifically considered research well process control applications
higher order structures originate specific reversible dna directed self assembly microscopic building blocks hold great promise future technologies functionalized biotinylated soft colloid oil water emulsion droplets biotinylated single stranded dna oligonucleotides using streptavidin intermediary linker show components modular linking system stable induce sequence specific aggregation binary mixtures emulsion droplets three length scales thereby involved nanoscale dna base pairing linking microscopic building blocks resulted macroscopic aggregates visible naked eye aggregation process reversible changing temperature electrolyte concentration addition competing oligonucleotides system reset reused subsequent refunctionalization emulsion droplets dna directed self assembly oil water emulsion droplets therefore offers solid basis programmable recyclable soft materials undergo structural rearrangements demand range application information technology medicine
high level exposures number agents known direct nephrotoxic effects children growing body literature supports hypothesis chronic relatively low level exposure various nephrotoxicants may also increase risk chronic kidney disease ckd accelerate progression review highlight several environmental nephrotoxicants association ckd children adolescents also discuss unique epidemiological challenges use kidney biomarkers environmental nephrotoxicology
high resolution peripheral quantitative computed tomography pqct quantifies bone microstructure density distal tibia also sizable amount myotendinous muscle tendon tissue however method quantification study aimed assess feasibility using pqct distal tibia scans estimate properties using custom algorithm determine relationship properties distal tibia mid leg muscle density obtained pqct postmenopausal women hamilton cohort canadian multicenter osteoporosis study single slice site pqct scan measuring muscle cross sectional area mcsa standard pqct scan acquired distal tibia pqct derived cross sectional area csa density mtd calculated using custom algorithm thresholds identified muscle seed volumes iteratively expanded pearson bland altman plots used assess correlations systematic differences pqct pqct derived muscle properties among women mean age years body mass index mtd moderately correlated mid leg across modalities bland altman analyses revealed evidence directional bias mtd pqct pqct measures csa mcsa moderately correlated bland altman plots csa revealed larger mcsas related larger discrepancy distal mid leg locations first study assess ability pqct measure size density morphometry pqct derived mtd moderately correlated mid leg pqct relationship suggests distal may share common properties muscle throughout length leg future studies assess value pqct derived properties context falls mobility balance
high resolution quantitative precipitation estimation qpe radar satellite combined rain gauges one important guides hydrological forecasts whereas rain gauges provide accurate measurement point remote sensing helps retrieve spatial pattern algorithm named siprec used blend rain gauges radar mosaic data satellite eumetsat mpe estimates using poisson equation two basins brazil results indicated siprec decreased root mean square error rmse compared radar satellite estimates well improved correlation errors related precipitation mmh due large spatial variability typical deep convection solution poisson equation acts directly data received certain time converging amplitude rain gauge values keeping spatial distribution radar satellite measurement without priori adjustments important advantage operational environment require frequent processing update weights like schemes american society civil engineers
high resolution ultrasound imaging musculoskeletal tissue increasing popularity patient tolerability low cost ability visualize tissue real time motion superior resolution highly organized tissue tendon prolotherapy defined injection growth factors growth factor production stimulants grow normal cells tissue controversial procedure decades currently gaining popularity among physiatrists musculoskeletal physicians report describes imaging tendons ligaments media meniscus disease trauma degeneration although tissues poorly responsive nonsurgical treatment proposed tissue growth repair prolotherapy structures documented ultrasound confirmed magnetic resonance imaging directions future research application discussed
high temperature superconducting hts generators large scale wind power generation systems attract much research attention excitation systems hts generators particularly brushless hts exciters new challenge verify possibility brushless hts exciter large scale wind power generator designed fabricated hts coils laboratory scale wind power generator employing brushless exciter order supply current hts coils brushless exciter considered generator field coils wound hts coated conductor made gdbco wire conduction cooling test executed cryogenic test chamber check performances detailed results operating performance hts coils discussed detail
hippocampal sclerosis aging aging common neurodegenerative condition associated dementia learn genetic risk aging pathology tested gene based associations grn tmemb abcc kcnmb genes reported associated aging pathology previous studies genetic data obtained alzheimer disease genetics consortium linked autopsy derived neuropathological outcomes national alzheimer coordinating center subjects included study identified aging case significant gene based association abcc gene aging appeared driven region significant haplotype based association found tested haplotype expression quantitative trait locus using different public access brain gene expression databases aging pathology protective abcc haplotype associated decreased abcc expression indicating possible toxic gain function elsevier inc rights reserved
histone deacetylase hdac inhibitor abexinostat investigation treatment various cancers epigenetic changes including aberrant hdac activity associated cancers including myelodysplastic syndromes mds acute myeloid leukemia aml acute lymphoblastic leukemia phase dose escalation study patients relapsed refractory higher risk mds aml received oral abexinostat starting dose twice daily bid days day cycles common treatment related grade adverse events thrombocytopenia neutropenia none led discontinuation maximum tolerated dose reached evaluable patients best response stable disease patient study closed due limited clinical benefit future development oral abexinostat bid patients mds aml focus combination regimens isrctn registry
historians regarded passage comstock laws death knell public discourse gender sex reproduction thrived early nineteenth century united states view given way complex appreciation strategies available actors seeking knowledge body examine strategies late century health hygiene manuals although certain discourses sex became closed others persisted evolved interstices comstock regulatory state readers demand information abate savvy publishers found different ways meet utilizing suggestion allusion nontextual cues active readers could extract useful knowledge public debate morality effectiveness appropriate use contraception become coded pages health hygiene manuals pointing readers burgeoning mass market contraceptive devices locus reproductive control
historians usually analyze changing gender constructions criminal courts world war cases involving men women using different analytical lens article explores two well publicized murder trials involving war veterans illegiti mate children one soldier murdered wife daughter adulterous affair one killed son although notions masculinity changed police courts home office used traditional factors assess punishments including degree provocation behavior women involved issue deterrence press however sympathetic veterans regarding victims circumstances much like women committed infanticide new presentation succeed home office especially war moved past men war service less influence punishment victorian ideas gender criminal responsibility
historically recovery substance use disorders sud focused exclusively use non use addictive substance recently samsha defined recovery holistic way using quality life qol measure recovery individuals substance use mental health disorders however little known myriad experiences inform affect qol individuals substance use disorders using attachment informed stress buffering framework purpose study examine contribution parental warmth recovery support qol among women substance abuse treatment linear regression bootstrapping used examine direct mediated effects parental warmth recovery support qol among women recruited three inner city women addiction treatment programs relationships assessed across three domains quality life physical psychological social parental warmth recovery support directly associated psychological social qol controlling influence trauma symptoms recovery support mediated relationship parental warmth qol across psychological social qol domains findings suggest interventions focus attachment related constructs enhance recovery support may improve quality life among women sud
hiv treatment prevention tasp initiatives promote antiretroviral therapy art access optimal adherence produce viral suppression among people living hiv plhiv prevent onward transmission hiv art treatment interruptions common among plhiv use drugs undermine effectiveness tasp semi structured interviews conducted plhiv use drugs experienced treatment art interruptions setting community wide tasp initiative vancouver canada examine influences outcomes study participants attributed art interruptions treatment fatigue analysis revealed individual social structural influences events including prior adverse art related experiences among long term treatment histories experiences social isolation breakdowns continuity hiv care following disruptive events eviction incarceration findings reconceptualise treatment fatigue focusing attention underlying mechanisms demonstrating need comprehensive structural reforms targeted interventions optimize tasp among drug using plhiv
hiv aids scourge remains high countries sub saharan africa nigeria home million hiv positive individuals represents second largest burden hiv aids care treatment demand worldwide south africa anti retroviral treatment options though welcome development increased number people living chronic illness depend family members physical emotional support traditional gender norms nigeria ensure legitimately women girls first options caregiving roles mandatory role turn imposed psychosocial disruption lives female family members calabar nigeria descriptive study utilized convenient sampling technique zarit burden interview scale semistructured questionnaires data collection respondents data analyses achieved using spss study showed significant proportion women involved providing care including children years caregivers minimal social support increased burden experienced need policy recognizes supports female caregivers silent cornerstone reduce burden ensure high quality care people living hiv aids plwha nigeria advocated
hiv positive kenyan men sex men msm highly stigmatized group facing barriers care engagement antiretroviral therapy art adherence care providers views important improving outcomes sought perspective serving msm patients optimize art adherence setting sex behavior criminalized conducted focus group discussions total healthcare workers hcws experienced providing hiv care msm semistructured open ended topic guide used based access information motivation proximal cues model adherence added focus trust providers stigma discrimination detailed facilitator notes transcripts translated english reviewed common themes hcw identified adherence challenges msm patients similar general population including hiv related stigma lack disclosure addition hcws noted challenges specific msm lack access msm friendly health services economic social challenges due stigma difficult relationships care providers discrimination clinic community hcws recommended clinic staff sensitivity training use trained msm peer navigators stigma reduction community interventions might improve adherence health outcomes msm despite noting msm specific barriers hcws recommended strategies improving hiv care msm rights constrained settings merit future research attention likely multilevel interventions incorporating individual structural factors necessary
hmgcs mitochondrial hydroxy methylglutaryl coa synthase control enzyme ketogenesis mitochondrial localization interaction app beta amyloid precursor protein suggest hmgcs may play role pathophysiology alzheimer disease report overexpression hmgcs decreased levels app related ctfs carboxy terminal fragments largely prevented autophagic inhibitor chloroquine addition hmgcs enhancement autophagic marker lcii diminished rapamycin inhibitor mechanistic target rapamycin moreover deprivation ebss earle balanced salt solution significantly augmented effect hmgcs lcii acetoacetate reversed reduction lcii app ctfs induced hmgcs knockdown presence acetoacetate rapamycin failed induce increase lcil mimicked effect hmgcs overexpression finally hmgcs enhanced antioxidant response collectively hmgcs shares ketone bodies common features autophagic clearance app ctfs suggesting ketone bodies play important role hmgcs regulation autophagy elsevier inc rights reserved
hollow silica spheres synthesized template sol gel approach using cationic polystyrene template tetraethoxysilane teos precursor void size hollow silica sphere decided diameter templates hollow silica spheres controllable size obtained varying parameters polymerization monomer initiator stabilizer polarity dispersion medium shell thickness hollow silica spheres could easily changed range changing teos concentration mmol mmol size shell thickness hollow silica spheres effects bulk density thermal conductivity strength materials
homeless adults use emergency department services frequently adults relationships homelessness health status outpatient service use utilization poorly understood data collaborative initiative help end chronic homelessness cich used compare use among chronically homeless adults receiving comprehensive housing case management mental health addiction primary care services cich sites use among comparison group clients receiving generally available community services sites multiple imputation used account missing data differential rates attrition cohorts longitudinal models constructed compare use groups first year initiation cich services mediation analysis performed determine relative contributions housed receipt outpatient services health status group differences utilization participants receiving cich services significantly less likely report use odds ratio confidence interval year program entry decreased use primarily mediated decreased homelessness increased access services health status suggests becoming housed key driver reduced utilization efforts provide housing homeless adults may result significantly decreased use research needed determine long term effects housing health status develop services improve health outcomes
hormones present hair provide summative information endocrine activity hair growing therefore collected infant birth still provide retrospective information hormone exposure prenatal development employed approach determine whether delimited period maternal stress pregnancy affected concentrations glucocorticoids gonadal hormones hair neonatal rhesus monkeys hair infant monkeys exposed weeks gestational disturbance compared specimens infants undisturbed control pregnancies using based technique permitted seven steroid hormones quantified simultaneously found hormones significantly different infants disturbed pregnancies cortisol testosterone levels lower hair male female neonates maternal hair hormone levels collected day delivery longer showed effects disturbance earlier pregnancy study documents period acute stress lasting gestation sustained effects hormones developing fetus exposed elsevier ltd rights reserved
host genetic factors may influence establishment chronicity spontaneous clearance viral hepatitis infections light shed role played interferon stimulated genes innate immunity myxovirus resistance one key genes reported inhibit several viruses present study aims explore possible association promoter variants susceptibility chronic hepatitis spontaneous clearance moroccan population snps genotyped pcr rflp individuals stratified hbv chronically infected patients hcv chronically infected patients hbv spontaneously resolved subjects hcv spontaneously resolved group healthy controls significant association allele hbv spontaneous clearance found addition significant correlation haplotype hbv spontaneous clearance found significant association polymorphisms regard hcv infection observed study show north african patients chronic hepatitis gene variation position may influence outcome hbv infection hcv infection wiley periodicals inc
hot forging processes spur gear shaft three billet sizes simulated using fem billet size phi best formability hot forging spur gear shaft effects initial billet temperature friction coefficient hot forging formability spur gear shaft obtained respectively simulation hot forging experiments carried experimental results show good agreement simulation last reasonable hot forging parameters spur gear shaft manufacturing engineering suggested follows billet size phi billet initial temperature degrees friction coefficient
hotel premises fundamental component tourism hospitality design construction operation end life cycle processes hotel premises built environment exerts positive negative impacts guest surrounding environment carbon emission hotel premises one major sources greenhouse effect urban areas counteract tendencies therefore necessary identify green building practices implemented hotel building carbon emission order reduce environmental impact minimize operational cost maximizing economic social opportunities study proved substantial integration spatial landscape design combination right selection plant materials based characteristics carbon sequestration rate hotel premise optimized consequently role plants trees sequestering carbon emission best understood greatest opportunity carbon sink may explored study aimed predict carbon sequestration rate plant materials integration vertical horizontal landscape design decisive outcome study green practice applied monitoring carbon toxicity cost effective environmental friendly carbon neutralization
find general way choose suitable samples training classifier even limited prior information active learning regarded iterative optimization procedure plays key role construct refined training set improve classification performance variety applications text analysis image recognition social network modeling etc although combining representativeness informativeness samples proven promising active sampling state art methods perform well certain data structures find way fuse two active sampling criteria without assumption data paper proposes general active learning framework effectively fuses two criteria inspired two sample discrepancy problem triple measures elaborately designed guarantee query samples possess representativeness unlabeled data also reveal diversity labeled data appropriate similarity measure employed construct triple measures meanwhile uncertain measure leveraged generate informativeness criterion carried different ways rooted framework practical active learning algorithm proposed exploits radial basis function together estimated probabilities construct triple measures modified best versus secondbest strategy construct uncertain measure respectively experimental results benchmark datasets demonstrate algorithm consistently achieves superior performance state art active learning algorithms
donors reason justify choices faced dilemmas charitable context two studies swedish students confronted helping dilemmas based identifiable victim effect proportion dominance effect ingroup effect dilemma consisted two comparable charity projects participants asked choose one project asked provide justifications choice stating relative importance different types reasons faced identified victim dilemma participants choose project including identified victim often project framed statistically emphasized emotional reasons empathic feelings reasons choosing statistical project faced proportion dominance dilemma participants often chose project high rescue proportion save project low rescue proportion save emphasized efficacy reasons money make greater difference reasons favoring low recue proportion project finally faced ingroup dilemma participants often chose project could help ingroup victims project could help outgroup victims emphasized responsibility reasons greater obligation reasons favoring outgroup projects results consistent extend previous findings different helping effects related different psychological processes
people appropriate virtual hand representation interacting virtual environments order answer question conducted experiment studying sense embodiment interacting three different virtual hand representations one providing different degree visual realism keeping control mechanism main experimental task pick place task participants grasp virtual cube place indicated position avoiding obstacle brick barbed wire fire additional task considered participants perform potentially dangerous operation towards virtual hand place virtual hand close virtual spinning saw qualitative measures questionnaire data gathered order assess sense agency ownership towards virtual hand results show sense agency stronger less realistic virtual hands also provide less mismatch participant actions animation virtual hand contrast sense ownership increased human virtual hand provides direct mapping degrees freedom real virtual hand
epstein barr virus ebv affects clinical outcome ebv positive diffuse large cell lymphoma dlbcl remains largely unknown viral oncogene lmp crux tumorigenesis cell survival therefore examined association lmp high cells drug resistance first assessed slamf surrogate marker lmp high cells lmp target gene ccl highly expressed slamfhigh farage cells cells survived longer following treatment combination cyclophosphamide doxorubicin vincristine prednisone chop genes associated interferon alpha allograft rejection kappa stat also overexpressed surviving farage cells specifically chop treatment increased lmp pstat expression levels dose dependent fashion addition exogenous greatly increased levels lmp pstat rendered farage cells resistant chop regulating anti apoptotic genes bcl mcl farage cells sensitive velcade stat inhibitors inhibition kappa stat combination chop decreased lmp levels effectively induced cell death farage cells suggest lmp high cells responsible poor drug response ebv dlbcl perturbation kappa stat signaling pathways increases toxicity cells
evolutionary novelties evolve major question evolutionary biology widely accepted changes environmental conditions shift position selective optima advancements phylogenetic comparative approaches allow rigorous testing correlated transitions longstanding question vertebrate biology evolution terrestrial life histories amphibians investigating african bufonids test whether terrestrial modes reproduction evolved adaptations particular abiotic habitat parameters reconstruct date complete species level molecular phylogeny estimate ancestral states reproductive modes correlating continuous habitat measurements remote sensing data locality records life history transitions discover terrestrial modes reproduction including viviparity evolved multiple times group often directly fully aquatic modes terrestrial modes reproduction strongly correlated steep terrain low availability accumulated water sources evolutionary transitions terrestrial modes reproduction occurred synchronously transitions habitat therefore interpret terrestrial breeding adaptation abiotic conditions rather exaptation facilitated colonization montane habitats
control monitor devices home question last century overwhelming answer engineering field technological development recent years allowed perform task using software hardware tools monitoring different devices smart phone comes simply downloading app entering website article presents application example answer aforementioned question
transfer trained detector target scenarios important topic long time field computer vision unfortunately existing transfer methods need keep source samples label target samples detection phase therefore difficult apply real applications problem propose framework consists controlled convolutional neural network ccnn modulating neural network mnn ccnn parameters last layer classifier dynamically adjusted mnn target sample ccnn adaptively generates proprietary classifier contributions include first detector based unsupervised transfer method suitable real applications new scheme dynamically adjusting classifier new object function invented experimental results confirm method achieve state art results two pedestrian datasets spie
describe similarity relationship biological sequences basic important problem bioinformatics first graphical representation method similarity relationship rather single sequence proposed article makes similarity intuitional properties sensitivity continuity similarity proved theoretically indicate similarity describer advantage alignment alignment free methods aid multiresolution analysis tools exhibit similarity different profiles high resolution low resolution idea multiresolution clustering raised first reassortment analysis benchmark flu virus genome data set test method shows better performance alignment method especially dealing problems involving segments order
human activities affect ecosystem dynamics pose continuous challenge individuals communities trying survive arid semi arid regions development method employ rainwater harvesting rwh management agricultural drought arid semi arid regions comprised two phases detection agricultural drought egypt beheira governorate using normalized difference vegetation index differencing technique delineation rwh locations potentially suitable management agricultural drought region using gis decision support system dss temporal vegetation cover analysis showed significant spatio temporal changes occurred last years general decrease vegetation cover reflecting trend towards ecosystem degradation contrasted greening trend pockets within region potentially suitable rainwater harvesting areas agricultural drought management attendant vegetation recovery delineated region using dss model generated rwh map five categories suitability excellent good moderate poor unsuitable average study area classified excellent good rwh respectively area classified moderate unsuitable poor respectively areas excellent good suitability predominantly lie areas faced severe drought successfully implement drought management plan number rwh sites within excellent areas must developed
human activity recognition har important research area computer vision due vast range applications specifically past decade witnessed enormous growth applications human computer interaction intelligent video surveillance ambient assisted living entertainment human robot interaction intelligent transportation systems review paper provides comprehensive state art survey different phases har techniques related segmentation image physical objects feature extraction activity classification thoroughly reviewed compared finally paper concluded research challenges future directions
human antimicrobial rnases belong vertebrate rnase superfamily secreted upon infection display wide spectrum antipathogen activities work examined antifungal activity eosinophil rnase skin derived rnase two proteins expressed innate cell types directly involved host defense fungal infection candida albicans selected suitable working model testing rnase activities toward eukaryotic pathogen explored distinct levels action rnases yeast combining cell viability membrane model assays together protein labeling confocal microscopy site directed mutagenesis applied ablate either protein active site key anchoring region cell binding first integrated study highlights rnases dual mechanism action along overall membrane destabilization process rnases could internalize target cellular rna data support contribution enzymatic activity antipathogen action antimicrobial proteins envisaged suitable templates development novel antifungal drugs suggest human rnases work multitasking antimicrobial proteins provide first line immune barrier
human behaviour context dependent based predictions influenced environment people live dynamic world social stimuli context constantly changing similar dynamic natural stimuli future increasingly used study social brain functions parallel development appropriate signal analysis methods understanding dynamic neural processes also requires accurate time sensitive characterization behaviour beyond traditional stimulus response approaches brain activity recorded simultaneously two interacting subjects reveal human social interaction critically different reacting theme issue attending neglecting people contains original work review papers person perception social interaction articles cover research neuroscience psychology robotics animal interaction research microsociology papers authored scientists presented independent views recent attention performance xxvi conference brave enough join forces colleague different background views future information needs converge across disciplines provide holistic view human behaviour interactive nature well temporal dynamics social world
human immunodeficiency virus hiv negative factor nef protein accessory pathogenic factor plays significant role acquired immune deficiency syndrome aids nef deficient hiv virus took longer time progress aids therefore targeting nef protein considered key strategy towards hiv aids treatment date compounds reported nef inhibitors prompted provide first account integrated computational framework order identify potential nef inhibitors herein using hybrid ligand shape similarity pharmacophore structure molecular docking based virtual screening approaches combined molecular dynamics well post dynamics analysis potential new hits identified hiv nef inhibitors top ranked compounds molecular docking shape similarity based library zinc delta bind kcal mol pharmacophore based library zinc delta bind kcal mol possess comparatively better binding affinities reference molecule delta bind kcal mol hits zinc zinc showed similar binding mode binding site like prototype hydrophobic electrostatic interactions seemed prominent binding forces hold ligands dimer interface nef protein finally set chemical structural features used guide design novel potential nef inhibitors also highlighted herein believe information gained study would great importance discovery design potential small molecules targeting hiv nef
human movement patterns shown particularly variable many combinations activity different muscles achieve task goal goal equivalent nervous system appears automatically vary output among goal equivalent combinations muscle activity minimize muscle fatigue distribute tissue loading neural mechanism good variation unknown use bimanual finger task electroencephalography eeg machine learning determine cortical signals predict goal equivalent variation finger force output healthy participants applied left right index finger forces repeatedly perform task involved matching total sum right left finger force previous studies observed significantly variability goal equivalent muscle activity across task repetitions compared variability muscle activity would achieve goal participants achieved task repetitions right finger force less left finger force right left repetitions less right finger force left finger force left right found eeg signals milliseconds prior task repetition could make significant prediction repetitions would right left would left right also found cortical maps sites contributing prediction contain motor pre motor representation appropriate hemisphere thus goal equivalent variation motor output may implemented cortical level
human pharmaceuticals commonly detected environment concern compounds environment center around potential pharmaceuticals interfere endocrine system aquatic organisms main focus endocrine disruption research centered estrogenic androgenic compounds interact endocrine system elicit reproductive effects classes compounds progestins overlooked recently studies investigated potential synthetic progestins impair reproduction growth aquatic organisms present study utilizes oecd early life stage els study investigate impacts levonorgestrel lng synthetic progestin fathead minnow fhm survival growth days post hatch survival larval fhm impacted growth significantly reduced analysis conducted measuring specific endocrine related mrna transcript profiles fhm larvae following day els exposure lng transcripts beta hsd beta hsd cyp alpha fsh significantly regulated following exposure lng exposure significantly regulated beta hsd beta hsd cypa fsh lng significant regulation occurred cypa beta transcripts mpr alpha mpr beta profiles significantly induced significant changes occurred beta hsd cypa star beta vtg mrna expression following lng exposure vivo steroidogenesis assay conducted sexually mature female fhm following day exposure lng significant reductions observed pregnenolone alpha beta dihydroxy pregnen one dhp testosterone ketotestosterone together data suggest lng negatively impact fhm larval survival growth significant alterations endocrine related responses elsevier rights reserved
human serpinb serpinb evolutionary duplicated serine cysteine protease inhibitors genomic analysis indicates paralogous genes encoded independent loci arising tandem gene duplication although two molecules share identity amino acid sequences distinct reactive center loop rcl including hinge region catalytic sequences accounts altered substrate specificity elevated expression two molecules reported contribute numerous pathological conditions inflammatory diseases cancer review focus summarizing biochemical features serpinb discussing mechanistic basis biological functions implications human diseases published elsevier ltd
humane education long standing field education endeavors nurture kindness compassion concern nonhuman animals people environment despite long history however randomized control studies evaluated effectiveness promote development relevant outcomes current study sought address dearth investigating effects humane education program participating students attitudes also behaviors classes served fourth grade students two major cities randomly assigned participate either school based humane education program chess club control group students participated respective activity period week weeks data collected attitudes behaviors participating students exactly one week exactly one week programs conducted students self reported attitudes treatment animals environment via intermediate attitude scale teachers rated students prosocial disruptive behaviors sub scales teacher observation classroom adaptation checklist nested multilevel models change found development prosocial behaviors self reported attitudes significantly interacted group assignment students participated humane education program showed stronger growth outcomes compared students control group changes disruptive behaviors ever found differ groups results support effectiveness humane education program teach relatively large diverse group upper elementary students learn animal welfare issues improve prosocial behaviors effects appeared strongest attitudes behavioral effects found largely limited behaviors directly addressed humane education program
humans exhibit extensive large scale cooperation form unprecedented natural world suggest cooperation arises species alone uniquely potent capacities social learning imitation teaching combined evolutionary feedbacks capabilities generated human mind culture took human populations evolutionary pathways available non cultural species either creating conditions promoted established cooperative mechanisms indirect reciprocity mutualism generating novel cooperative mechanisms seen taxa cultural group selection process gene culture evolution seemingly generated evolved psychology comprising enhanced ability motivation learn teach communicate language imitate emulate well predispositions docility social tolerance sharing goals intentions attention evolved psychology entirely different observed animal could evolved conventional selection genes alone
hybrid electrical vehicles hevs able improve fuel economy reduced emissions due effective power management regenerative power utilization however developing optimal supervisory control strategy distribute power quite challenging due high degrees freedom introduced multiple power sources hevs conventional approach uses called power follower scheme power management also achieved minimizing equivalent fuel consumption given instant without guaranteeing battery state charge soc maintains target level paper proposes model predictive control mpc strategy based linear quadratic tracking lqt control follow predicted driver power demand given horizon keeping battery soc operated target level lqt controller developed based upon linearized control oriented model used optimally track predicted desired torque trajectory minimizing total equivalent fuel consumption internal combustion engine electric motor given finite prediction horizon operational point performance mpc based lqt controller validated simulations four typical driving cycles simulation results show fuel economy greatly improved baseline power follower control strategy especially ftp driving cycles time battery state charge maintained desired level
hydraulic turbine governing system htgs complicated nonlinear system regulates frequency power hydropower generating unit previous study control model htgs always overly simplified elastic water hammer model seldom considered paper nonlinear htgs model elastic water hammer effect studied fuzzy pid controller designed improve control quality system order optimize fuzzy pid controller novel gravitational search algorithm based cauchy mutation mass weighing gsa proposed two improvements weighting strategy designed accelerate convergence assigning weights agents mass calculation combined mutation strategy based cauchy gaussian distribution proposed balance exploration exploitation ability proposed algorithm first searching ability gsa verified set complex benchmark functions statistical analysis gsa applied optimize fuzzy pid controller different meta heuristics different pid controllers employed comparison experimental results indicate fuzzy pid controller optimized gsa effective improve control quality nonlinear htgs elsevier rights reserved
hydrogen produced solar energy via photocatalytic water splitting process hydrogen oxygen produced environment inert gas nitrogen used reactor order eliminate explosion hazards case study membrane cascade design implemented recover hydrogen outside flammability range using commercial polyimide membrane industries japan two different ternary mixtures investigated recover purify hydrogen outside flammability range mixture contains mol hydrogen mixture contains mol process optimization defined nonlinear programming nlp aim objective function minimize present value outgoing cash flows income separation process flammability recovery constraints satisfied kmol hydrogen feed basis results showed high investment operating costs mixture specific cost maximum recovery purity achieved without increase cost respectively switching mixture result specific cost reduction around due lower feed flow rates higher molar concentrations hydrogen maximum recovery purity beyond values specific cost increase dramatically first fundamental process optimization considering safety issues well product recovery yield simultaneously tertiary gas mixture hydrogen energy publications llc published elsevier ltd rights reserved
hydrogen promising energy carrier port fuel injection pfi fuel flexible durable relatively cheap method energy conversion however contradiction increasing power density controlling nox emissions limits wide application pfi hydrogen internal combustion engines address issue two typical thermodynamic cycles miller otto cycles studied based calculation model proposed study thermodynamic cycle analyses two cycles compared results show thermal efficiency miller cycle eta miller higher eta otto multiplied result inlet pressure miller cycle coefficient delta gamma larger otto cycle value inlet pressure ratio multiplied miller cycle coefficient larger value inlet pressure ratio otto cycle results also show intake valve closure ivc miller cycle limited inlet pressure valve lift two factors show boundaries miller cycle increasing power density turbocharged pfi hydrogen engine ways lean burn otto cycle stoichiometric equivalence ratio burn egr otto cycle seo miller cycle turbocharged hydrogen engine compared results show miller cycle highest power density lowest bsfc among three methods engine speed rpm nox emissions ppm brake power miller cycle increases higher higher seo gamma bsfc miller cycle decreases lower lower seo however advantage miller cycle decreases increase engine speed findings used guidelines developing turbocharged pfi hydrogen engines miller cycle indicate boundaries development new hydrogen engines elsevier ltd rights reserved
hydrogen peroxide one reactive oxygen species ros cause intracellular oxidative stress associated skin aging photoaging curcumin polyphenol turmeric reported exhibit biological activity study five naturally occurring curcuminoids curcumin demethoxycurcumin dmc bisdemethoxycurcumin bdmc monohydroxy dmc monohydroxy bdmc used investigate protective roles hydrogen peroxide induced oxidative stress immortalized human keratinocyte cell lines hacat cells five curcuminoids shown exhibit cytotoxicities toward hacat keratinocytes therefore concentration five curcuminoids selected investigations cells pretreated without curcuminoids hydrogen peroxide treatments pretreatments minor components monohydroxy dmc monohydroxy bdmc curcumin dmc bdmc showed protective activity elevating cell viability compared cells direct hydrogen peroxide treatments pretreatments monohydroxy dmc monohydroxy bdmc showed best protective effects reducing apoptotic cell populations intracellular ros demonstrated flow cytometry well reducing changes mitochondrial membrane potential compared cells direct hydrogen peroxide treatments pretreatments monohydroxy dmc monohydroxy bdmc reduced jun fos mrna expression tumor suppressor protein expression increased protein expression glutathione peroxidase gpx activity respectively compared cells direct hydrogen peroxide treatments five curcuminoids exhibited similar hydrogen peroxide scavenging activity vitro proposed monohydroxy dmc monohydroxy bdmc could induce antioxidant defense systems better curcumin dmc bdmc could hydrogen peroxide induced oxidative stress apoptosis hacat keratinocytes may potential ingredients antiaging cosmetics skin care
hydrological investigation behavior watershed depend upon geo morphometric characteristics catchment morphometric analysis commonly used development regional hydrological model ungauged watershed critical valuation assessment geomorphometric constraints carried prioritization watersheds based water plot capacity piperiya watershed evaluated linear aerial relief aspects morphometric analysis attempted prioritization nine sub watersheds piperiya watershed hasdeo river basin tributary mahanadi sub watersheds delineated arcmap software per digital elevation model dem assessment drainages relative parameters stream order stream length stream frequency drainage density texture ratio form factor circulatory ratio elongation ratio bifurcation ratio compactness ratio calculated separately sub watershed using remote sensing geospatial techniques finally prioritized score basis morphometric behavior sub watershed assigned thereafter consolidated scores estimated identify sensitive parameters analysis reveals stream order varies however first order stream covers maximum area total number stream segment order watershed study emphasizes prioritization sub watersheds basis morphometric analysis final score entire nine sub watersheds assigned per erosion threat sub watershed least compound parameter value assigned highest priority however sub watersheds categorized three classes high medium low priority basis maximum minimum prioritized score
hydrological processes play important roles soil erosion processes hillslopes study conducted investigate hydrological processes associated erosional responses purple soil slope based comprehensive survey wangjiaqiao watershed three gorges reservoir four typical slope gradients degrees degrees degrees degrees applied five rainfall intensities min results showed surface subsurface runoff varied greatly depending rainfall intensity slope gradient surface runoff volume times subsurface runoff critical slope gradient degrees sediment yield rate increased increases rainfall intensity slope gradient effect rainfall intensity sediment yield rate greater slope gradient good linear relationship sediment yield rate reynolds numbers flow velocity stream power froude numbers darcy weisbach manning friction coefficients good hydraulic indicators sediment yield rate purple soil erosion among three good indicators stream power best predictor sediment yield rate finally based power regression relationship sediment yield rate runoff rate slope gradient rainfall intensity erosion model proposed predict purple soil erosion results help understand relationship flow hydraulics sediment generation slope erosion offer useful data building erosion model purple soil
hyperosmotic stress affects cell growth decreasing cell volume increasing uptake organic osmolytes however sensitivity embryonic cells osmotic treatment remains established analysed aspects cell cycle control amino acid transport hypertonic conditions prenatal life effects hyperosmotic stress amino acid uptake mediated system thymidine incorporation regulation cell cycle proteins analysed chick embryo hepatocytes hypertonic stress increased system activity caused cell cycle delay effects amino acid transport involved kinase activation new carrier synthesis cyclin cdk cyclin dependent kinase pcna proliferating cell nuclear antigen levels decreased whereas cyclin levels unchanged incorporation leucine indicated decreased synthesis cyclin contrast analysis mrna qrt pcr quantitative real time showed net increase cyclin transcripts suggesting post transcriptional regulation data show chick embryo hepatocytes respond hyperosmotic conditions arresting cell growth prevent dna damage increasing osmolyte uptake regulate cell volume indicating adaptive response environmental stress exists prenatal life
hyperspectral image hsi classification become active research area remote sensing field order construct simple reliable classifier learning adequate distance metric given hsi dataset still critical challenging task many hsi applications paper novel distance metric learning dml framework based manifold embedding dme named dldme proposed hsi classification dme framework developed using recently developed smooth ordering technique framework enables elaborately exploit benefits dml development dme algorithm core state art dml learn amahalanobis matrix given dataset better describes similarity pixels largest margin nearest neighbors lmnn information theoretic metric learning itml employed mahalanobis matrix learning based affinity defined mahalanobis matrix preclassifiers constructed using simple regularization dme predict labels test data voting rule pixels labeled class preclassifiers voted confidently predicted set merged current labeled set labeled set enlargement process repeated original one small size final classifier constructed dme framework based enlarged labeled set according aforementioned strategy two novel dml based dme classification algorithms dldme lmnn dldme itml developed paper
hyperspectral remote sensing data carry information leaf area index lai forests thus principle lai estimated based data inverting forest reflectance model however lai usually unknown reflectance model especially leaf spectral albedo understory reflectance also known uncertainties parameters accounted inversion forest reflectance model lead biased estimates lai paper study effects reflectance model uncertainties lai estimates investigate whether lai estimates could recover uncertainties aid bayesian inference proposed approach unknown leaf albedo understory reflectance estimated simultaneously lai hyperspectral remote sensing data feasibility approach tested numerical simulation studies results show presence unknown parameters bayesian lai estimates account model uncertainties outperform conventional estimates based biased model parameters moreover results demonstrate bayesian inference also provide feasible measures uncertainty estimated lai elsevier ltd rights reserved
hypertension male aging female rodents associated glutamate dependent plasticity hypothalamus existing models failed capture distinct transitional menopausal phases could significant impact synaptic plasticity emergent hypertension rodents accelerated ovarian failure aof induced systemic injection vinylcyclohexane diepoxide mimics estrogen fluctuations seen human menopause including perimenopause transition peri aof postmenopause post aof thus used mouse aof model determine impact slow pressor angiotensin ang administration blood pressure subcellular distribution obligatory methyl aspartate nmda receptor giun subunits paraventricular hypothalamic cleus pvn key estrogen responsive cardiovascular regulatory area estrogen sensitive neuronal profiles identified mice expressing enhanced green fluorescent protein promoter estrogen receptor beta major pvn slow pressor angll increased arterial blood pressure mice peri post aof time points control oil injected nonhypertensive mice angll decreased total number giun err containing pvn dendrites contrast angll resulted reapportionment giun cytoplasm plasma membrane beta containing pvn dendrites peri aof mice moreover post aof mice angll increased total giun dendritic size radical production err containing neurons results indicate unique patterns hypothalamic glutamate receptor plasticity dendritic structure accompany elevated blood pressure peri post aof time points findings suggest possibility distinct neurobiological processes associated increased blood pressure perimenopausal postmenopausal periods
hypertension risk factor cognitive impairment older age however evidence neural basis relationship deterioration cognitive function elevated blood pressure sparse based previous research speculate variations brain connectivity closely related elevated blood pressure even onset clinical conditions apparent cognitive decline individuals years age forty cognitively healthy adults recruited received blood pressure test cognitive assessment various domains diffusion tensor imaging dti resting state functional magnetic resonance imaging rsfmri data collected findings confirm elevated blood pressure associated brain connectivity variations cognitively healthy individuals integrity splenium corpus callosum closely related individual differences systolic blood pressure particular elevated systolic blood pressure related resting state ventral attention network van information processing speed serial mediation analyses revealed lower integrity splenium statistically predicts elevated systolic blood pressure turn predicts weakened functional connectivity within van eventually poorer processing speed current study sheds light neural correlates involved impact elevated blood pressure cognitive functioning
hypertension important modifiable risk factor cardiovascular disease mortality high salt intake may predispose children develop hypertension later modest reduction population salt intake worldwide would result major improvement public health regarding smoking another risk factor various strategies used promote smoking cessation physicians excellent position help patients stop smoking targeted weight loss interventions population subgroups might effective prevention hypertension general population approach diet rich high potassium fruit vegetables strongly recommended fresh products best normal potassium content reduced foods canned frozen calcium supplementation reduces blood pressure hypertensive individuals chronic nitric oxide synthase inhibition high calcium diet enhances vasorelaxation nitric oxide deficient hypertension magnesium considered anyone seeking prevent treat high blood pressure foundation healthy blood pressure consists healthy diet adequate exercise stress reduction sufficient amounts potassium magnesium investigations required making definitive therapeutic recommendations magnesium use alcohol usage frequent contributor hypertension generally appreciated hypertensive patients stress appears important issue stress management considered intervention individualized cognitive behavioral interventions likely effective single component interventions
ibudilast ibd non selective phosphodiesterase pde inhibitor used mainly bronchodilator treatment bronchial asthma pde play central role cellular function differentiation synaptic plasticity inflammatory response metabolizing cyclic nucleotides results preclinical clinical studies indicate ibd broader range action suppression pro inflammatory cytokines beta tnf alpha toll like receptor blockade tlr inhibition macrophage migration inhibitory factor mif regulation anti inflammatory cytokine promotion neurotrophic factors gdnf ngf recent data indicate efficacy ibd appears independent pde inhibition activity rather linked glial activity attenuation additional advantages ibd crossing blood brain barrier good tolerance activity oral administration makes promising therapeutic candidate treating neuroinflammatory conditions currently available treatment remains unsatisfying due poor tolerability sub optimal efficacy ibd direct receptor affinity exemption undefined effect adenosine receptors makes drug devoid receptorsme diated adverse effects current article provides overview pharmacology ibd focus preclinical clinical data supporting potential neuroprotective benefits neurological conditions including multiple sclerosis neuropathic pain medication overuse headache stroke opioid alcohol methamphetamine abuse
identification somatic frameshift mutations exon calreticulin gene calr myeloproliferative neoplasms mpns december remarkable finding provided new molecular diagnostic marker particularly essential thrombocythemia primary myelofibrosis pmf second common altered gene jakvf two main types calr mutants type type evidence distinct clinical prognostic implications instances believed favorable outcome might restricted type pmf using reasoned approaches recent publications supported classifying alternative mutants type like type like studies confirm results new considerations may taken account molecular diagnosis mpns implies precise mutation characterization must performed caution taken screening technique selection editorial summarize current information regarding issues
idiopathic pulmonary fibrosis ipf chronic fibrosing interstitial pneumonia unknown cause characterised progressive worsening lung function dyspnoea associated prognosis similar worse many cancers better understanding emerges around pathogenesis mechanisms driving disease pathology host novel agents tested pre clinically clinically however even deeper understanding positive pre clinical supportive data negative trial outcomes frequently reported highlighting problems faced treating heterogeneous disease varied clinical course recently two therapies slow disease progression nintedanib pirfenidone approved treatment ipf yet clinical unmet need still high ipf patients given failure stop disease progression potential side effect profiles efforts made understand underlying pathways genetics might influence clinical course disease also non invasive biomarkers reflect activity specific pathways turn may highlight progressive treatment plans individual patients cumulative data may based identification subgroups patients via biomarker analysis ongoing clinical trials investigation cohorts patients time understand relative role mediators disease progression review ongoing quest novel therapeutic approaches highlight appropriate attempts made identify patients specific pathway mediator may driving disease progression elsevier inc rights reserved
idiopathic pulmonary fibrosis ipf progressive interstitial lung disease unclear etiology poor prognosis despite numerous studies pathogenesis ipf scant treatment options available management ipf glaucocalyxin gla ent kaurane diterpenoid demonstrated exert anti inflammatory anti neoplastic anti platelet activities study evaluated role gla anti fibrotic agent bleomycin induced pulmonary fibrosis mice investigated underlying mechanisms gla attenuates lung fibrosis intraperitoneal administration gla significantly reduced collagen deposition hydroxyproline content mouse lungs treated bleomycin importantly gla significantly improved survival bleomycin treated mice addition gla reduced weight loss mice reflects cachexia due pulmonary fibrosis mechanistically gla alleviated infiltration macrophages neutrophils lungs attenuated increases proinflammatory cytokines lung tissue bronchoalveolar lavage fluid inhibited activation kappa fibrotic lungs induced bleomycin results provide evidence gla effectively ameliorate pulmonary fibrosis antagonism leukocyte infiltration proinflammatory cytokine production suggesting may become potential anti fibrotic agent ipf management elsevier inc rights reserved
idiopathic pulmonary fibrosis ipf common form chronic interstitial lung disease severe progressive fibrotic disorder unknown aetiology disease heterogeneous clinical course frequent poor prognosis similar malignant disease correctly diagnosing ipf become particularly important view availability precise therapeutic indications thus avoiding steroid treatment allowing new approaches novel drugs date limited information biomarkers predictive progressive disease associated complications efforts made future appropriately study lung tissue extrapolate clinically fitting biomarkers approach already used routine management many cancers provides potential road map appropriate clinical care ipf review mainly focus histology etiopathogenesis highlighting morphological molecular features may influence overall management ipf
iga vasculitis primarily pediatric disease rarely encountered adults adults gastrointestinal manifestations quite common yet nonspecific may overlap diseases particularly crohn disease make diagnosis challenging task treatment controversial given disease course usually self limited serious complications present case iga vasculitis adult patient limited extraintestinal findings illustrating complexity arriving correct diagnosis
ige mediated cannabis sativa marihuana allergy seems rise active passive exposure cannabis allergens may trigger sativa sensitization allergy clinical presentation sativa allergy varies mild life threatening reactions often seems depend route exposure addition sensitization cannabis allergens result various cross allergies mostly plant foods clinical entity designated cannabis fruit vegetable syndrome might also imply cross reactivity tobacco natural latex plant food derived alcoholic beverages hitherto cross allergies predominantly reported europe appear mainly rely upon cross reactivity nonspecific lipid transfer proteins thaumatin like proteins present sativa homologues ubiquitously distributed throughout plant kingdom present diagnosis cannabis related allergies predominantly rests upon thorough history completed skin testing using native extracts crushed buds leaves however quantification specific ige antibodies basophil activation tests also helpful establish correct diagnosis absence cure treatment comprises absolute avoidance measures whether avoidance use halt extension related cross allergies remains uncertain
tissue signaling cytokines favor protection regeneration barrier organs skin lung gastrointestinal system cytokines share cellular sources signaling pathways functional aspects however taking closer look differ pro inflammatory regenerative potential imbalance carefully orchestrated tissue signaling system might result autoimmune diseases promote cancer growth predispose infectious diseases review highlights recent understandings cellular sources signaling mechanisms physiologic well pathogenic role double faceted cytokines
cytokines expressed variety cells mediate host defence extracellular pathogens upregulated sites inflammation synergize cytokines tnf alpha amplify inflammatory response activation signalling pathways hypothesized contribute underlying pathogenesis several inflammatory diseases including psoriasis psa asthma thus signalling pathway attractive target development therapeutic agents modulate aberrant inflammatory responses review clinical development therapeutic agents target signalling pathways inflammatory diseases focuses brodalumab human anti receptor mab cumulative findings early clinical studies anti agents including brodalumab secukinumab ixekizumab provide strong evidence role signalling pathophysiology certain inflammatory diseases support potential use agents treating diseases
ilrl also known member superfamily known ligand exists two forms splice variants soluble form sst acts decoy receptor sequesters free signal membrane bound form activates myd kappa signaling pathway enhance mast cell regulatory cell treg innate lymphoid cell type functions sst levels increased patients active inflammatory bowel disease acute cardiac small bowel transplant allograft rejection colon gastric cancers gut mucosal damage viral infection pulmonary disease heart disease graft versus host disease recently sst shown secreted intestinal pro inflammatory cells gut inflammation contrary protective expressing tregs decreased implicating signaling may play important role intestinal disease review focus known signaling various inflammatory disease states highlight potential avenues intervene signaling treatment options
image coding systems currently undergoing standardisation within iso ccitt final outcome process incremental improvements classical hybrid transform predictive algorithms task vlsi architecture synthesis complete systems made somewhat awkward due unstructured irregular non modular nature algorithms hoc methodology pruning architectural search space directed goal minimizing overall internal memory leads strongly control flow solution using pipeline scheme efficient original signal flow graph generic image coding processor using parallel programmable architecture another solution may inferred second generation image coding techniques designed massive fine grain parallelism view take advantage full potential dedicated vlsi implementations
image registration deals establishing correspondences images scene object image registration algorithm handle variations introduced imaging system capturing scene scale invariant feature transform sift image registration algorithm based local features image compared previous registration algorithms sift robust variations caused changes size illumination rotation viewpoint images owing performance algorithm widely studied modified successfully applied many image video based applications domains medicine industry defense paper outcome extensive study state art image registration algorithms based sift around algorithms based sift algorithm discussed classification made based objective basic algorithm modified comparative study performance methodology technique presented along applicability various image processing applications domains
image segmentation crucial step image processing especially medical images however existence partial volume effect noise artifacts makes problem much complex fuzzy means fcm effective tool deal partial volume effect deal noise artifacts paper one modified fcm algorithm proposed solve problems includes three main steps peak detection used initialize cluster centers make initial centers close final ones turn decrease number iterations fuzzy clustering incorporating spatial information implemented make algorithm robust image artifacts segmentation results refined detecting reallocating misclassified pixels experiments performed synthetic medical images results show proposed algorithm effective reliable fcm based algorithms
image sparse representation methods widely applied many image processing fields computer vision image noising super resolution visual tracking efficient sparse representation method improve accuracy however traditional representation methods consider point anti packing problem thus methods restricted size image also lose great amount detail information using symmetric blocking method paper proposed image sparse representation method called namiet transform nam lets haar type wavelets based non symmetric homogeneous blocks obtained non symmetry anti packing model homogeneous blocks pixels bit plane namiet transform reduce lost detail information remove restrictions image size experiment results show strong superiority namiet transform image representation comparison state art image sparse representation methods elsevier rights reserved
immigrants important part australian labor force constitute major source net labor force growth immigrants arriving australia however face number barriers finding employment commensurate training education reid australian new zealand journal public health end poor quality jobs series interviews focus groups newcomers study examined immigrants experience finding employment working conditions australia manuscript specifically explore discrimination shaped workers experiences strategies workers used overcome deal barriers encountered end discussion racism consequences impact quality work worker health safety
immune suppressive therapies target exaggerated deleterious responses immune system triggered exogenous endogenous factors improper responses lead immune inflammatory manifestations urticaria equine asthma autoimmune immune mediated diseases glucocorticoids commonly used immune suppressive drugs ones supported robust evidence clinical efficacy equine medicine conditions combining glucocorticoids pharmacologic nonpharmacologic treatments azathioprine antihistamine bronchodilators environmental management desensitization help decrease dosages associated side effects
immunoglobulin mediated food allergy eosinophilic esophagitis eoe chronic allergen mediated disorders characterized aberrant immune response development investigation biologics treatment ige mediated food allergy eosinophilic esophagitis provided insight pathophysiology management disorders article provides overview biologic therapies investigated potential treatments ige mediated food allergy eosinophilic esophagitis identification eoe phenotypes responsive biologics investigation biologics combined therapies may help elucidate role biologics eoe
immunotherapies include various approaches ranging stimulating effector mechanisms counteracting inhibitory suppressive mechanisms creating forum discussing effective means advancing therapies imaging focus newly formed imaging cellular immune therapies icit interest group within world molecular imaging society efforts made identification validation predictive biomarkers number immunotherapies without predictive biomarkers considerable number patients may receive treatments chance offering benefit reflect poorly field immunotherapy yield false hopes patients time contributing significant cost healthcare system review summarizes main strategies cancer immune cell based therapies discusses recent advances imaging strategies aimed improve cancer immunotherapy outcomes
impact bar key part buffer bed long distance conveyor equipment characteristics high energy absorption low friction product spillage scattering elimination state art application impact bar metal matrix composites mmcs introduced paper emphatically explained impact bar structure integrated process new theories computer aided development buffer investigation main concerns impact bar include structure composition performance index key technology damping technology laser texturing genetic algorithm simulation optimization computer aided design analysis testing manufacturing process development impact bar furthermore manufacturing standard quality control data mining impact bar design urgent exploited future authors published elsevier ltd
impact loads initiate damages several forms indentation fiber breakage matrix cracking delamination cracking carbon fiber reinforced polymer cfrp study rapid diagnosis finish inspecting whole aircraft structure within hour refueling developed composite aircraft proposed method consists two steps first target detection indentation whole structure second one delamination cracking indentation detected first step inspect limited area around indentation delamination inspection therefore make use indentation marker impact damage save inspection time money even large cfrp components inspected first step indentation detection indentation increases fiber fiber contact interlaminar interface electrical conductivity consequently electrical current applied material concentrate around indentation lead selective intense resistive heating temperature increase observed thermography detected change electrical resistance caused temperature difference second step delamination around indentation detected without sampling data intact structures using statistical treatment moreover false diagnoses changes electrical resistance caused damage electrical contacts electrodes prevented
impaired beta cell function key development type diabetes cocaine amphetamine regulated transcript cart islet peptide insulinotropic glucagonostatic properties studied role endogenous cart beta cell function cart silencing ins beta cells reduced insulin secretion production atp levels beta cell exocytosis substantiated reduced expression several exocytosis genes well reduced expression genes important insulin secretion processing addition cart silencing reduced expression network transcription factors essential beta cell function moreover rnaseq data human islet donors cartpt expression levels correlated insulin exocytosis genes key beta cell transcription factors thus endogenous beta cell cart regulates insulin expression secretion ins cells via actions exocytotic machinery network beta cell transcription factors conclude cart important maintaining beta cell phenotype elsevier rights reserved
impaired intra hemispheric inter hemispheric communication play major role pathophysiology cognitive disturbances bipolar disorder brain connectivity largely investigated using magnetic resonance imaging mri techniques found alterations prefronto limbic coupling contrast evidence functional neural circuitry abnormalities less consistent indeed studies employing electroencephalographic eeg technique enabling exploration oscillatory brain dynamics addressed issue therefore present review summarize results eeg studies examining connectivity patients clarify putative role neuronal network synchronization potential biomarker disabling mental illness
impaired ventricular myocardial mechanics observed patients repaired tetralogy fallot rtof effects pulmonary valve replacement pvr ventricular remodeling controversial objective assess impact surgical pvr ventricular mechanics pediatric patients rtof speckle tracking analysis performed rtof children aged years pre operatively months post pvr early post operative studies months post pvr performed patients cardiac magnetic resonance cmr pre post pvr collected mid term post pvr right ventricular longitudinal strain increased pre operative strain increases observed individual segments left ventricular strain differ medium term follow longitudinal strain reduced early post operatively followed recovery biventricular systolic strain mid term follow cmr end diastolic indexed volumes correlated strain pre operatively mid term follow volume loaded rvs reduced early basal longitudinal strain compared pressure loading conditions reversed basal counterclockwise rotation associated lower mid term global basal strain compared patients normal rotation increase mid term global regional strain beyond pre operative values suggests positive remodeling adaptation occurs children post pvr patients larger pre operative volumes lower strain post operatively impact rotation mechanics highlights presence ventriculo ventricular interactions findings important clinical implications pediatric rtof patients towards identifying pre operative factors predict post operative remodeling
implicit evaluations reflect people gut response toward attitude object based associative processes starting ground reflective processes subsequent explicit evaluations present research examined determinants consequences implicit evaluations rape case situational specifics rape case personal factors rape myth acceptance demonstrated influence explicit implicit judgments rape case moreover sex participant influenced participants implicit evaluations affected explicit judgments indirectly via implicit evaluation people gut response shown affect explicit judgment case effect particularly pronounced people low need cognition people like engage effortful processing discussion focuses role implicit cognition implicit biases judicial decision making
implicit representations gained increasing popularity geometric modeling computer graphics due ability represent shapes complicated geometry topology however storage requirement memory disk usage implicit representations complex models relatively large paper propose compact representation multilevel rational algebraic spline mras surfaces using low rank tensor approximation technique exploit applications surface reconstruction given set points equipped oriented normals first fit algebraic spline surface defined box bounds point cloud split bounding box eight sub cells fitting error greater given threshold sub cell fitting error greater threshold offset function represented algebraic spline function low rank computed locally solving convex optimization problem algorithm presented solve optimization problem based alternating direction method multipliers admm candecomp parafac decomposition tensors procedure recursively performed certain accuracy achieved ensure global continuity mras surface quadratic spline weight functions used blend offset functions numerous experiments show approach greatly reduce storage reconstructed implicit surface preserve fitting accuracy compared state art methods furthermore method good adaptability able produce reconstruction results high quality elsevier ltd rights reserved
implicit representations geometry found applications shape modeling simulation graphics pipelines representations however provide information paths individual points shapes move undergo deformation reason reconsider problem tracking points level set surfaces goal designing algorithm unlike previous work recover rotational motion nearly isometric deformation track points level sets time varying function using approximate killing vector fields akvfs velocity fields near isometric motions end provide suitable theoretical discrete constructions computing akvfs narrow band surrounding animated level set surface furthermore propose time integrators well suited integrating akvfs time track points demonstrate theoretical practical advantages proposed algorithms synthetic practical tasks
important energy reductions achieved building sector providing occupants feedback energy consumption levels recent studies link success energy feedback methods level occupant engagement people social circles resulting peer pressure conform certain social norms despite promising results literature remains limited scope individual rather groups buildings limited design feedback initiatives leveraging social connections exist induced within buildings current paper addresses identified gap proposing multilayer agent based model serves test bed simulate optimize feedback methods applied building stock community city monte carlo sensitivity analyses show connecting occupants different buildings increasing engagement feedback mechanism lead energy reductions exceeding findings confirm role social networks energy conservation diffusion setting stage large scale socially engaging energy conservation initiatives american society civil engineers
improper functioning traffic signals intersections result extreme congestion leading increase overall journey time wastage precious fuel various algorithms proposed literature alleviating problem congestion fixed time non preemptive preemptive approaches work towards reduction queue length intersections decrease overall waiting time roads high traffic volume road results large queue length takes huge amount time process using single processor hence need fast processing obtained parallelizing algorithm paper proposes parallel preemptive algorithm reduce average queue length resulting decrease overall waiting time implementation parallel algorithm done using compute unified device architecture cuda harnessing power graphical processing units gpus performance proposed parallel preemptive algorithm compared fixed time non preemptive preemptive approaches obtained results show reduction queue length case proposed algorithm also confirmed using test confidence elsevier inc rights reserved
improve quality life one main concerns public agenda cities around world quality life closely related satisfaction daily needs people needs satisfied neutral needs men women different result gender roles androcentric urban architecture contributes satisfying needs women men asymmetrical quality city life fair following article reflects concept quality life urban dimension impact gender definition measurement term
improvement noise performance transconductance using positive feedback approach bulk driven operational amplifier proposed paper downscaling cmos technology compelled supply voltage reduce turn demands reduction threshold voltage overcome barrier threshold bulk driven technique good non conventional approach require modification existing structure mosfet limitation bulk driven approach transconductance operational amplifier get reduced almost three four times thanks loop positive feedback resulting transconductance boosted higher value thus increasing voltage gain decreasing input referred noise concept positive feedback used design low voltage low power building blocks operational amplifier using standard cmos technology though amplifier designed power supply also capable operate supply less simulation carried using mentorgraphics tools technology
improving engines achieved use new electronic control systems combustion process additional installation devices catalysts oxidation fuel etc direction large number organizations work spend heavily research field processes tribochemical friction surfaces showed certain conditions surfaces covered polymer film containing nanoparticles film capable reducing friction coefficient times essential order falling friction losses allows reducing fuel consumption internal combustion engine oils called energy saving oils possess effect reducing friction coefficient composition oils include coordinating transition metal compounds esters organic acids involved processes tribochemical forming tribopolymer films investigated motor oil sae includes pentaerythritol ester oil soluble coordination compound molybdenum concentrate additives komol tests conducted internal combustion engine fixed part stand including single cylinder gasoline engine alternator measuring tanks gasoline well measuring block power meter bench tests shown fuel consumption reduced level reduced similar effect observed tested operating conditions passenger cars
improving thermostability enzyme accelerate relevant chemical reaction thus analysis prediction thermophilic proteins conducive protein engineering enzyme design study novel method based two step discrimination proposed distinguish thermophilic non thermophilic proteins model rigorously benchmarked objective dataset including thermophilic proteins non thermophilic proteins results showed overall accuracy method fold cross validation higher published methods believe two step discriminated strategy become promising method relevant field protein bioinformatics
impulsivity often develops disturbed inhibitory control function mainly regulated aminobutyric acid gaba levels anterior cingulate cortex acc fronto striatal system study combined mrs gaba measurements fmri investigate neurochemical neurofunctional correlates interference inhibition emphasizing direct relationship two systems well relations impulsivity patients bpd addition bold activation task dependent functional connectivity assessed generalized psychophysiological interactions approach full factorial analyses performed via spm examine main effect within group associations well interaction term group differences association slope upps scales used evaluate impulsivity traits compared healthy controls hcs bpd patients exhibited significantly less acc caudate functional connectivity interference inhibition acc gaba levels bpd patients hcs positively related magnitude activation several fronto striatal regions acc frontal regions putamen caudate strength acc caudate functional connectivity interference inhibition strength correlations gaba connectivity significantly differs two groups moreover among upps impulsivity subscales upps sensation seeking bpd group related gaba also negatively related task dependent bold activation functional connectivity fronto striatal network finally mediation analyses revealed magnitude activation caudate strength acc caudate functional connectivity mediated relationship acc gaba levels upps sensation seeking patients bpd findings suggest disconnectivity fronto striatal network bpd patients interference inhibition particularly patients higher impulsivity acc gabaergic system seems play crucial role regulating regional bold activations functional connectivity network associated impulsive sensation seeking bpd
reported multiple biological effect including immunological inflammatory tumor killing activity since family cytokines discovered inflammatory anti inflammatory activity review article speculate possible inhibitory effect light new findings formerly termed family member binding receptor chain acts cytokine intracellular well extracellular functionality natural inhibitor immune responses inflammation inhibits many pro inflammatory cytokine increases anti inflammatory cytokines asthma pathogenesis involves multiple cell types including mast cells important cellular constituents human innate adaptive immunity impact inflammatory cytokines generated mast cells beneficial protective asthma however precise mechanism safety tolerability unclear still remain mystery abbreviations gbp guanylate binding proteins hmgb high mobility group box protein nlrp nucleotide like receptor pyrin domain asc apoptosis associated speck like protein containing card caspase recruitment domain fgf fibroblast growth factor
jock collins boldly suggested australia earlier migrant arrivals subject prejudice often become perpetrators prejudice indeed collect oral histories post war migrants regularly confronted angry statements asylum seekers let given everything lies heart phenomenon clearly prejudice stereotyping exists societies seems particularly evident societies ongoing flow migrants continues change alter ethnic racial mix article reflects upon research conducted hostel stories project frequently confronted stereotyped prejudicial even racist comments migrants refugees interviews migrants statements made ask whether collins correct observations drawing literature various disciplines consider various influences migrant attitudes towards migrants propose critical continue progress beyond conventional topics explored migration studies ask difficult questions order contribute growing global discussion ethnicity intergroup relations especially relation prejudice racism
steller kohnken presented systematic compilation content characteristics distinguishing truthful fabricated testimonies criteria based content analysis cbca designed applied within comprehensive overall diagnostic procedure known statement validity assessment sva steller subsequent years seen marked increase knowledge distinction experience based non experience based statements supports sva approach permits better explanation underlying processes rationale cbca true statement differs content quality fabricated account truth teller draw episodic autobiographical representation containing multitude details whereas liar relate scripts containing general details event liar busier strategic self presentation truth teller present article proposes modified model content characteristics pays greater attention underlying processes sva takes account content quality influenced veracity statement also personal contextual variables need considered individual credibility assessment theoretical analyses empirical research indicate comparable qualitative differences true statements based false memories witnesses giving testimony based false memories fabricate false statements actively make effort conceal deception deceiving mistaken cases noncritical application content criteria lead false results examine hypothesis statement based false memory necessary focus way statement emerged evolved
international continence society defined term overactive bladder oab symptom syndrome accompanied urgency without urge incontinence frequency nocturia proven urinary tract infection obvious pathologies must excluded pathophysiology oab clarified detail subject ongoing research partially overlapping hypotheses exist urothelium based hypothesis suggests functional changes urothelial receptors well functional changes regarding sensitivity coupling suburothelial myofibroblasts ultimately lead increasing activity afferent signals urgency myogenic hypothesis based assumption unstable detrusor contractions may triggered changes excitability coupling myocytes myofibroblasts unstable detrusor contractions generate increased afferent activity followed symptoms overactive bladder hypothesis abnormal processing afferent signals assumes damage central inhibitory pathways sensitisation afferent nerves lead activation micturition reflex turn induces unstable detrusor contractions addition hormonal psychological influences discussed
alyans sante borgne asb conducted irst week long mobile hospital molas poor mountain community walk main hospital town borgne north haiti asb partnership haiti outreach pwoje espwa based ngo haiti ministry health paper relects irst experience evolution indigenous model health care delivery sante nan lakou snl health extended family level model prioritizes needs patients institution highlights challenges providing quality care much neglected segment population documents impact event community asb lessons learned week shaped asb response root causes women children poor health commune borgne response articulated holistic grassroots program called sante health edikasyon education ekonomi economy fanm women see fanm see fanm constellation programs initiatives together brings quality care women seeks empower take charge health wellbeing extension families communities
medicare beneficiaries began receiving prescription coverage benefits part medicare benefit medicare part plans must provide medication therapy mtm services mtm services aim improve medication use targeted toward eligible beneficiaries determined morbidity prescription use anticipated cost prescription use years start medicare part several changes made program design article focuses changes related mtm impact changes continue medicare beneficiaries medication use
context growing awareness prevalence mental disorders cognitive modeling emerged important contribution study mind processes computational models proved indispensable tools precise systematic simulations cognitive processes potential application diagnosis treatment pathologies propose connectionist cognitive model incorporates regulatory mechanisms called regulated activation networks rans applied modeling psychological phenomena paper summarizes current early stages development rans model objectives principles approach taken described well architecture rans model preliminary results plans future work
context increasing landscape modifications climatic changes scale hierarchy becomes ever crucial issue integrate analysis drivers stressors biological communities especially river networks cope issue developed spatial hierarchical models functional diversity stream invertebrate communities assess relative influence local regional scale factors structuring community assembly analysis metacommunity elements determine ecological processes behind structuring spatial structuring benthic invertebrate cominunities investigated sites south eastern france community structure mainly driven altitudinal gradient spring flow variation broad scales functional diversity gradually decreasing elevation maximized intermediate levels flow variability according elements metacommunity structure analysis prevailing influence altitudinal gradient also supported clenientsian structuration invertebrate communities conversely influence observed climatic changes temperature rainfall weak observed fine scales result natural environmental filters stronger drivers functional diversity communities human induced stressors water pollution hydromorphological alterations broadly results suggest management needs embrace possibilities gathering high spatial taxonomical resolution data analysing predicting flow variation climate change effects order preserve restore functionally diverse communities moreover develop environmental flow schemes restoration climate change adaptation strategies freshwater communities local regional processes need addressed simultaneously equally responsible drivers community diversity elsevier rights reserved
conventional electricity market trading conducted based power forecasts day ahead market power imbalance regulated real time market separate trading scheme large scale wind power connected power grid power forecast errors increase day ahead market lowers economic efficiency separate trading scheme paper proposes robust unified trading model includes forecasts real time prices imbalance power day ahead trading scheme model developed based robust optimization view undefined probability distribution clearing prices real time market model used efficiently improved quantum behaved particle swarm algorithm iqpso presented paper based depth analysis limitations static character quantum behaved particle swarm algorithm qpso finally impacts associated parameters separate trading unified trading model analyzed verify superiority proposed model algorithm
digital multisignature scheme two signers allowed produce single signature common message verified anyone literature many schemes available based public key infrastructure identity based cryptosystem bilinear pairing map point mtp hash function bilinear pairing mtp function time consuming operations need large super singular elliptic curve group moreover cryptosystems based difficult implement less efficient practical use best knowledge certificateless digital multisignature scheme without pairing mtp hash function yet devised objective fulfilled paper furthermore formally prove security scheme random oracle model assumption ecdlp hard
strong designated verifier signature scheme designated verifier determine identity signer others identify signer verifier date one strong designated verifier signature scheme lattices proposed random oracle model paper propose first strong designated verifier signature scheme lattices standard model proposed scheme satisfies requirements unforgeability nontransferability privacy signer identity scheme easily extended identity based strong designated verifier signature scheme identity based strong multi designated verifiers signature scheme copyright john wiley sons ltd
two server password authenticated key exchange pake protocol client splits password stores two shares password two servers respectively two servers cooperate authenticate client without knowing password client case one server compromised adversary password client required remain secure paper present two compilers transform two party pake protocol two server pake protocol basis identity based cryptography called ids pake protocol compilers construct ids pake protocols achieve implicit authentication long underlying two party pake protocol identity based encryption signature scheme provable security without random oracles ids pake protocols constructed compilers proven secure without random oracles compared katz two server pake protocol provable security without random oracles ids pake protocol save percent computation server
world facing rapid environmental changes anticipating impacts biodiversity utmost relevance remotely sensed ecosystem functional attributes efas promising predictors species distribution models sdms offering early integrative response vegetation performance environmental drivers species high conservation concern would benefit better ability anticipate changes habitat suitability illustrate yearly projections sdms based efas could reveal short term changes potential habitat suitability anticipating mid term shifts predicted climate change scenario models fitted two sets sdm plant species conservation concern iberian peninsula one calibrated climate variables baseline conditions projected two climate change scenarios future conditions calibrated efas projected annually range shifts predicted climate based models future conditions compared trends efas based models projections efas based models estimated changes mostly contractions habitat suitability anticipated majority species mid term shifts projected traditional climate change scenario forecasting showed greater agreement business usual scenario sustainable development one study shows satellite derived efas used meaningful essential biodiversity variables sdm provide early warnings range shifts predictions short term fluctuations suitable conditions multiple species published elsevier
acquired immunodeficiency syndrome aids studies quite common observe viral load measurements collected irregularly time moreover measurements subjected upper lower detection limits depending quantification assays complication arises continuous repeated measures heavy tailed behavior data structures propose robust structure censored linear model based multivariate student distribution compensate autocorrelation existing among irregularly observed measures damped exponential correlation structure employed efficient expectation maximization type algorithm developed computing maximum likelihood estimates obtaining product standard errors fixed effects log likelihood function proposed algorithm uses closed form expressions step rely formulas mean variance truncated multivariate student distribution methodology illustrated application human immunodeficiency virus aids hiv aids study several simulation studies
addition recently proposed full wave rectifier prommee using voltage mode two cell winner takes wta circuit present current mode precision full wave rectifier using two cell wta circuit popular lazzaro wta circuit employed purpose requirement inverting input signal also dual complimentary phases output current signal available high output impedance terminals explicit utilization compared many recently proposed rectifiers using complex active devices dual current conveyor universal voltage conveyor circuit compact requires total transistors spice simulation results circuit implemented using tsmc cmos technology provided verify workability proposed circuit
aircraft power generation system constant speed drive csd integrated drive generator idg play important part provide constant frequency power supply aircraft electrical systems however systems downsides particularly heavy fully mechanical tendency fail completely gears linkages break aircraft engine rotates much lower cycles per second required produce standard frequency aircraft electrical system power supply paper variable speed constant frequency vscf aircraft power generation system based high number input phases matrix converter proposed system tested boeing engine prime mover engine performance based typical flight profile aircraft proposed aircraft power generation system constant frequency output validated using modeling simulation matlab simulink
ambient intelligence system humans devices environment perform actions improve quality daily living person research normative systems could applied regulate operation kind systems nevertheless determining right norms trivial contribution discusses case parkinson disease patient particular paper studies watching scenario right moment assist patient subject discussion results obtained sociaal project whose aim integration social sciences concerns development kind systems reduction production cost
effort enhance instruction reach students educators design engaging online learning experiences often form online videos many instructional videos feature picture inpicture view instructor clear instructor presence influences learners visual attention contributes learning affect given knowledge gap study explored impact instructor presence learning visual attention perceived learning mathematics instructional videos varying content difficulty thirty six participants viewed two min long mathematics videos easy difficult topics instructor either present absent findings suggest instructor attracted considerable visual attention particularly learners viewed video easy topic although significant difference learning transfer found either topic participants recall information video better easy topic instructor present finally instructor presence positively influenced participants perceived learning satisfaction topics led lower level self reported mental effort difficult topic elsevier ltd rights reserved
environment people lifestyles increase risk initial recurrent cardiovascular disease cvd events community based healthy lifestyle initiatives highly effective providing programs education support reduce associated cvd risk factors improve outcomes pioneering programs stanford three community five cities studies north karelia project finland served prototypes current initiatives include partnerships national organizations ymca dpp faith based programs training may provided healthcare professionals community healthcare workers initiatives include exercise based weight reduction programs smoking cessation interventions dietary counseling education medication adherence contemporary technologies home based programs provide alternatives might otherwise access center based programs community based initiatives particularly state national support potential enhance delivery effectiveness cvd prevention low cost elsevier inc rights reserved
ancillary service electricity markets opportunity costs account profit forgone generator due use generating capacity ancillary service provision instead energy sales calculated generator providing ancillary services included determination market clearing prices market operators throughout recent interest use smart heating ventilating air conditioning systems ancillary service provision prompts investigation associated opportunity costs paper proposes definition costs method accounting time done recognizing impacts intra hour consumption modification associated ancillary service provision daily energy efficiency costs numeric example presented demonstrate method found marginal ancillary service opportunity costs vary time properly adjusting energy consumption hour interest reduce total opportunity cost providing ancillary services
arid semi arid regions quite often encounter granular soils high hydraulic conductivity loss irrigation water occurs due seepage well evaporation excess water resulting irrigation green yards eastern province saudi arabia found seep ground flow towards uncontrolled directions sand clay liners reinforced geotextile materials designed act smart barrier used harvest excess irrigation water engineering properties hydraulic conductivity sand clay liners investigated conditions yielding optimum output introduced based outcome laboratory test results carried mixtures qatif clay material fine dune sand study presents framework landscape designers benefit idea select appropriate proportions suit intended liners collected water examined used irrigation
asia two wheelers popular mode transportation large group people relative affordability ability maneuver heavy city traffic however rate fuel consumption emission contribution especially urban areas need attention improve sustain ability energy air quality recently plug hybrid technology emerged one promising alternatives reducing petroleum consumption emission paper presents implementation plug hybrid technology two wheeler formulation novel control strategy suitable indian city driving needs experimental investigations hub motor internal combustion engine carried fix change speed hybrid mode followed road test prototype vehicle performance prototype vehicle idc indian driving cycle simulated road pattern actual road driving confirmed change speed vehicle hybrid mode converted plug hybrid electric two wheeler also demonstrated drive strategy adopted higher energy efficiency times plug hybrid electric two wheelers show significant improvements fuel economy replacing petroleum fuel electricity portions trip achieve nations energy security elsevier ltd rights reserved
attempting understand increased rates immoral behavior associated psychopathic personality researchers largely focused identifying deficits reduced concerns well others however little understanding motivate individuals psychopathic traits individuals value life goals aspire within large online sample examined relationships psychopathic traits several measures values goals overall psychopathy related pleasure seeking desire relative social positioning individuals scoring higher psychopathy placed value seeking power necessarily personal achievement financial success acquiring material possessions demonstrated preference group based dominance social dominance orientation concerned relative position society absolute level income education vacation time study may help understand motivates behavior individuals scoring higher psychopathy going beyond identifying deficits reduced concerns welfare others examining individuals value discuss ways could useful developing treatments interventions take motivations account
cases maltreatment involving children army service members army family advocacy program fap responsible providing services families ensuring child safety percentage cases maltreatment known fap however uncertain thus objective retrospective study estimate percentage army dependent children child maltreatment diagnosed military civilian medical provider substantiated report fap medical claims data used identify year old child dependents soldiers received medical diagnosis child maltreatment linkage rates maltreatment medical diagnoses corresponding substantiated fap reports calculated bivariate multivariable analyses examined association child maltreatment episode soldier characteristics linkage substantiated fap reports across medically diagnosed maltreatment episodes substantiated fap report adjusting covariates predicted probability linkage substantiated fap report higher physical abuse sexual abuse versus episodes early care provided civilian treatment facilities less likely fap report treated military facilities versus observed low rates linkage medically diagnosed child maltreatment substantiated fap reports may signal need regulation fap reporting requirements particularly children treated civilian facilities elsevier ltd rights reserved
cesar department teenage pregnancy become social phenomenon requires attention government academic fieldsto tackle first referring last aspect article becomes reflexive contribution proposing emergence teen parenthood brings need address subjectivities experiences young parents well different roles behaviors attitudes within framework meaning consequences recognition acceptance exercise subject referring paternity within personal family social contexts thus propose broad vision teen pregnancy reduced simply biological physical conditions inserted dynamics different aspects psychology juridical cultural last aspect proposal analysis emergency importance young parenthood meaningful event one hand socially register masculinity hand assumption life project given changes implications teenager face realizes pregnancy birth finally raising son daughter test strength education man responsibilities entrance labor world necessary sacrifices generates
cities problems aridity shortage drinking water supply urgent need establish alternatives adequate water management program study proposes estimation users select rainwater harvesting system non drinking water consumption cities pachuca mineral reforma state hidalgo central mexico historical record rainfall analyzed covers period years calculated monthly volume rainwater harvestable roof areas household roof areas hra proposed replace single house flush toilets washing machine ecological devices consumptions flush load respectively furthermore maximum minimum consumption eight six flushes day person flush toilets five four loads week washing machine respectively proposed considerations estimations harvestable rainwater showed households hra would depend water supply system public network part year hand households hra might able store enough water meet needs besides toilet flushing laundry
classical earthquake risk assessment human behavior actually taken account risk assessment agent based modeling simulation technique applied recently several fields emergency evacuation paper proposing methodology includes agent based models human behavior considering anxiety effects generated crowd influence evacuation delays proposed model able take account interdependency earthquake evacuation process corresponding damage structural non structural components expressed term fragility curves software repast hpc used implement model case study earthquake evacuation mall located oakland used human behavior model calibrated survey using miscellaneous sample different countries model used test future scenarios help local authorities situations human behavior plays key role copyright john wiley sons ltd
cmos electronics using differential pairs input signals usually supplied gate terminals mos transistors creating pair tail terminal pair used ensure required bias needed proper operation transistors paper show roles gate tail terminals changed implies among others tail used terminal delivering input signal case new possibilities decreasing circuit power consumption occur especially making use current mode techniques power consumption drop zero input signal disappears combining current mode technique differential one enables achieve important circuit advantages like required small headroom simplicity realizing signal summation ability considerable reduction common mode effects characteristic differential methods last feature allows process even weak signals like case input stages popular differential amplifiers necessary conditions successful implementation proposed idea explained example simple cmos circuit operating according theoretical predictions made also presented
communication computing devices growing demand high performance battery operated portable equipments transferred concentration staid constraints area performance reliability power consumption present scenario cardinal requirement diminish power consumption non portable systems power dissipation leakage current censorious concerns vlsi circuits systems power dissipation still censorious leakage occurs device inactive mode reduce leakage power leakage current finfet based operational amplifier new circuit technique called low power state technique adduced paper approach reduces significant amount power active mode also endowment conserving state state retention mode amp electrical characteristics obtained employing cadence virtuoso tool circuit simulation input supply voltage simulated gain thus obtained active mode proposed finfet based operational amplifier performance traits studied compared existing cmos technology scale effect temperature variation electrical characteristics amp technology regime reconnoitered furthermore employing low power approach enhancement slew rate significantly attained simulation results given concluded
computer graphics mass spring model used obtain fast visual results physical simulations disadvantage method obtain accurate result difficulty define parameters mass spring model different works results carried define model parameters field researchers used optimization technique based meta heuristic method applied fabric properties fast kawabata test determine model parameters far research done using combination two mentioned methods recover mass spring parameters therefore purpose paper determine parameters mass spring model applying particle swarm optimization techniques fast test point effective properties fabric drape including stretch shear bending properties measured using fast system order reduce error value simulated actual fabric behavior parameters mass spring model super elasticity rate mesh topology natural length spring optimized applying particle swarm optimization pso pso parameters specified using taguchi design experiment finally fabrics drape simulated situations compared actual result validate model parameters results show optimized model able predict drape behavior knitted fabric error value percent compared real result
computer vision many problems formulated binary quadratic programs bqps general hard finding solution problem large size practical interest typically requires relaxation semidefinite relaxation usually yields tight bounds computational complexity high work present semidefinite programming sdp formulation bqps two desirable properties first produces similar bounds standard sdp formulation second compared conventional sdp formulation proposed sdp formulation leads considerably efficient scalable dual optimization approach propose two solvers namely quasi newton smoothing newton methods simplified dual problem significantly efficient standard interior point methods empirically smoothing newton solver faster quasi newton solver dense medium sized problems quasi newton solver preferable large sparse structured problems
construction projects building information modeling bim influences common way collaboration including roles different participants goal research explore current practices identify critical effects bim collaborative design construction focus group discussion interviews bim related participants explored project professions understandings bim implementation collaborative design construction adopted grounded theory analyze qualitative data eight concepts influencing development bim collaboration identified classified capacity technology management attitude behavior role taking trust communication leadership learning experience discussed taxonomy bim effects three dimensions technology people process findings provide empirical insights collaborative nature bim construction projects highlight importance collaboration within project teams bim project delivery elsevier ltd apm ipma rights reserved
cryptography one needs large families binary sequences strong pseudorandom properties last decades many families type constructed however many applications enough family good sequences large important know rich complex structure sequences family independent far apart thus various measures introduced applied studying pseudorandomness families binary sequences family complexity collision distance minimum avalanche effect cross correlation measure paper survey definitions results presented elsevier rights reserved
current study new approach vehicle active suspension actuator control reported approach nonlinear model electro hydraulic servo actuator quarter suspension system established oustaloup recursive approximation ora fractionalorder proportional integral derivative fopid controller designed control displacement actuator controller parameters optimized based error integral criteria using parallel adaptive clonal selection algorithm pacsa research indicates pacsa tune parameters fopid controller accurately efficiently tuned fopid controller performs better terms response speed tracking accuracy regular proportional integral derivative pid controller performance active suspension system uses fopid actuator obviously superior active suspension system uses pid actuator passive suspension system
developed country japan aging become serious issue disproportionate increasing elderly population longer able look order tackle issue introduce human friendly robot partner support elderly people daily life however realize essential robot partner able natural communication human paper proposes new communication framework human robot partner based relevance theory basis knowledge relevance theory implemented build mutual cognitive environment human robot partner namely informationally structured space iss inside iss robot partner employs verbal well non verbal communication understand human verbal communication rasmussen behavior model implemented basis conversational system non verbal communication environmental human state data along gesture recognition utilized data used perceptual input compute robot partner emotion experimental results shown effectiveness proposed communication framework establishing natural communication human robot partner elsevier ltd rights reserved
distributed computing environment task scheduling one important factors affect overall efficiency system task scheduling proved completeness problem way solve kind problem method exhaustion genetic algorithm one best algorithms solve completeness problem ability quickly approach optimal solution however still shortcomings genetic algorithm problem premature convergence paper improved genetic algorithm called genetic algorithm geographical isolation proposed restrains excessive growth phenomenon individuals dividing population effectively solves problem premature convergence genetic algorithm paper several sets experiments made compare operating efficiency final allocation effect algorithm scheduling algorithms prove algorithm improve efficiency algorithm without affecting quality final solution
divided societies promotion cross cultural contact education system central efforts improve intergroup relations approach informed understanding contact hypothesis suggests positive contact member different group contribute improvements attitudes towards group whole substantial body research provides support contact theory critics argued emphasis harmonious encounters result neglect group differences associated issues conflict discrimination contact research discussed article explores tension reference two shared education projects northern ireland research data gathered primarily interviews pupils confirms divisive issues rarely addressed contact explores several influences nature pupils relationships programme structure prevailing social norms avoidance
experimental studies assigned intervention measures received intervention full protocol adherence achieved rarely case public health objective study estimate effect brief counseling intervention delivered swedish dental clinics tobacco use cessation taking non adherence account conducted three secondary analyses per protocol analysis experimental counseling delivered intended contrasted usual care control treated analysis individuals compared according counseling components actually received disregarding randomization instrumental variable analysis effect intervention among would always treated assigned estimated logistic regression used examine association tobacco cessation outcomes seven day abstinence three month abstinence half reduction quit attempts defined exposure intervention protocol adherence intervention group per protocol analysis closely replicated results intention treat analysis showing statistically significant effect brief counseling reduction tobacco consumption significant effect outcomes treated analysis receiving counseling components compared tobacco counseling increased likelihood half reduction instrumental variable yielded biased results conclude despite application problems conducting per protocol treated instrumental variable analyses randomized trials experimental conditions strictly standardized strengthens puts context inference based intention treat analysis authors published elsevier inc open access article license
main book discorsie dimostrazioni matematiche intorno due nuove scienze published elsevier leiden galileo galilei father modern science put material science strength materials first place introduced notions stress strength fundamental since moreover unison plato theory forms found perfect shape force bent beam call today equistrong discovery laid foundation search perfect elastic bodies continuation galilei work theorems existence equistrong bodies quest like gold digging follows shapes following heavy equistrong beams found beam constant thickness variable width simply supported ends beam clamped one end loaded end either constant thickness variable width constant width variable thickness equistrong shape profile aircraft wings accounting gravity lift loads shape equistrong rod buckling compressive force found euler problem equistrong structures possess minimum weight given safety factor maximum safety factor given weight
image processing often desirable remove noise preserve image features due strong edge preserving ability total variation based regularization widely studied however produces undesirable staircase effect alleviate staircase effect lot model proposed lysaker ieee trans image process studied called two step method method started appear one effective methods image denoising includes two energy functions one normal field reconstruction image using normal field obtained first step however smoothed normal field related original noisy image first step enough paper proposed modified lot model image denoising lets reconstruction vector field related restored image addition compute new model design relaxed alternative direction method numerical experiments show new model obtain better results compared state art methods
intercourse men one partners typically assumes role insertive partner top assumes receptive role bottom although research suggests perceptions potential partners sexual roles gay men relationships affect whether man adopt role top bottom sexual intercourse remains unclear whether sexual roles could perceived accurately observers study found observers able discern men sexual roles photos faces accuracy significantly greater chance guessing moreover study determined relationship men perceived actual sexual roles mediated perceived masculinity together results suggest people rely perceptions characteristics relevant stereotypical male female gender roles heterosexual relationships accurately infer sexual roles sex relationships thus sex relationships sexual behavior may perceptually framed understood possibly structured ways similar stereotypes opposite sex relationships suggesting people may rely inferences form accurate perceptions
intergroup competition conflict humans benefit coalitions strong partners help protect group prevail competing groups link oxytocin neuropeptide produced hypothalamus ally selection intergroup competition double blind placebo controlled experiment males self administered oxytocin placebo made selection decisions six high threat six low threat targets potential allies intergroup competition males given oxytocin rather placebo viewed high threat targets useful allies frequently selected team low threat targets
june news chinese woman forced late term abortion quickly spread across internet china graphic photos woman aborted fetus provoked public outrage widespread condemnation social media sites aftermath local authorities apologized seven officials given demerits couple received monetary compensation case put spotlight mainly exposure story family members woman social media resulting public outcry cyberspace following disclosure story public reactions online article explores complex interplays among different layers state power individual public reproductive politics discusses ways social media utilized resist state control reproduction delving nuanced interactions among layers state authorities article sheds light study state society relations reproductive politics also calls attention role social media plays reproductive issues
light fact number elderly citizens society steadily increasing search dietary factors might prolong mental agility growing significance coffee together main ingredient caffeine focus much attention various researchers data beneficial effects human health continue accumulate reports indicate moderate coffee consumption may fact lower risk common neurodegenerative conditions alzheimer parkinson diseases regardless due complex pathogenesis well methodology scientific research exact impact coffee consumption remains fully elucidated present seems safe inform general public coffee drinkers need fear health possibly future experts recommend drinking coffee satisfy individual taste preferences also decrease age related mental deterioration
line trend toward continuous miniaturization price reduction crucial analyze impact uncertainties performance electrical circuits performance evaluated worst case scenario frequency domain computing upper lower bounds purpose propose method worst case tolerance analysis also provide efficient suitable tool electrical engineers easily applied realistic electrical engineering problems proposed method based robust analysis method called analysis well known efficient algorithms exist however order apply problem consideration transformed standard minimal called lft representation derivation difficult task even control systems engineers paper proposes transparent systematic lft derivation procedure users based knowledge electrical engineering end paper industrial example provided reveals benefits efficiency proposed approach applied linear electrical circuit
many applications offset amps canceled high accuracy accomplished work asymmetrical differential input circuit active offset rejection circuit implemented minimize systematic offset amplifier proposed amps show systematic offset voltages less
many institutions relational databases used tool managing information related day day activities institutions may required keep information stored relational databases accessible many reasons including legal requirements institutional policies however evolution technology change users passage time put information stored relational databases danger long term information may become inaccessible operating system database management system application software available contextual information stored database may lost thus affecting authenticity understandability information paper presents approach preserving relational databases long term proposal involves migrating relational database dimensional model simple understand easy write queries practical transformation rules developed carrying multiple case studies one case studies presented running example paper systematic implementation rules ensures loss information process except unwanted details database preserved using approach converted open format may reloaded database management system long term
many research application areas information retrieval machine learning often encounter dealing probability distribution mixed one distribution relevant task hand irrelevant want get rid thus essential problem separate irrelevant distribution mixture distribution article focused application information retrieval relevance feedback widely used technique build refined query model based set feedback documents however practice relevance feedback set even provided users explicitly implicitly often mixture relevant irrelevant documents consequently resultant query model typically term distribution often mixture rather true relevance term distribution leading negative impact retrieval performance tackle problem recently proposed distribution separation method dsm aims approximate true relevance distribution separating seed irrelevance distribution mixture one achieved promising performance empirical evaluation simulated explicit irrelevance feedback data deployed scenario one automatically obtain irrelevance feedback data article propose substantial extension basic dsm two perspectives developing regularization framework deploying dsm automatic irrelevance feedback scenario specifically order avoid output distribution dsm drifting away true relevance distribution quality seed irrelevant distribution input dsm guaranteed propose dsm regularization framework constrain estimation relevance distribution regularization framework includes three algorithms corresponding regularization strategy incorporated objective function dsm addition exploit dsm automatic pseudo irrelevance feedback automatically detecting seed irrelevant documents via three different document reranking methods carried extensive experiments based various trec datasets order systematically evaluate proposed methods experimental results demonstrate effectiveness proposed approaches comparison various strong baselines
mapreduce environment problem data redundancy large number tasks processing mass data storage come order solve problems put forward way data prefetching preprocessing hid remote data access latency adjusting allocation resources reduce business put forward method caused reduce tasks remote data access performance problems caused time delay resource competition system hidden prefetching data method reduce task remote data access latency reduce task control resource allocation reduce resource competition caused reduce task experiment results show default hadoop graphs hadoop online prototype hop compared method system performance improved
medical decision support systems accuracy ability adequately represent decision making processes well transparency interpretability ability provide domain user compact understandable explanation justification proposed decisions play essential roles paper presents approach automatic design fuzzy rule based classification systems frbcss medical data using multi objective evolutionary optimization algorithms moeoas approach generates single run collection solutions medical frbcss characterized various levels accuracy interpretability trade propose new complexity related interpretability measure address semantics related interpretability issue means efficient implementation called strong fuzzy partitions attribute domains also introduce special coding free representation rule base original genetic operators processing well implement ideas context well known one presently advanced moea non dominated sorting genetic algorithm nsga important part paper devoted broad comparative analysis approach many alternative techniques arranged experimental set ups applied three well known benchmark medical data sets breast cancer wisconsin original pima indians diabetes heart disease cleveland available uci repository machine learning databases http archive ics uci edu number useful medical applications performance measures including accuracy sensitivity specificity several interpretability measures employed results broad comparative analysis demonstrate approach significantly outperforms alternative methods terms interpretability obtained frbcss remaining either competitive superior terms accuracy worth stressing overwhelming majority existing medical classification methods concentrate almost exclusively accuracy issues elsevier ltd rights reserved
men harboring prolactinoma common symptoms related hypogonadism including decreased libido erectile dysfunction gynecomastia men characteristically present elevated serum prolactin prl levels suppressed gonadotropins low testosterone levels studied group unique men prolactinomas presenting testosterone levels within normal range parts per thousand yen cohort compared prolactinoma men borderline baseline testosterone cohort cohort prolactinoma patients low testosterone levels parts per thousand currency sign cohort mean testosterone levels presentation cohort range cohort cohort times normal cohort compared times normal cohorts symptoms hypogonadism present men groups respectively trend towards larger tumor size low testosterone group visual fields defects presentation prevalent cohort cabergoline testosterone level increased delta cohort delta cohort delta cohort group symptoms hypogonadism improved following treatment symptomatic men cohort normal testosterone exclude likelihood prolactinoma men treated cabergoline testosterone levels men increase higher within normal range together clinical improvement
mexico childhood cancer incidence mortality increased last decade government actions since popular medical insurance pmi program childhood cancer created objective pmi offer early cancer diagnosis standardized treatment regimens numerous pediatric oncology residency programs also accredited national hospitals care children current problems still present pmi include shortage pediatric oncologists nurses high rate abandonment treatment aim describe current scenario childhood cancer care mexico especially perspective pmi impacted human resources infrastructure medical education
modern operating systems thread primitive exploit concurrency provided multiple processors allows programmers write sequential code executed parallel however operating systems known inefficient number threads comes magnitude therefore server developers avoid use naive threading need handle thousands simultaneous client sessions paper propose highly scalable user level threading library thread enables programmer write heavily concurrent threaded code without losing performance framework achieves threading model hosts user level threads top kernel level threads demonstrate usefulness framework provide proof concept implementation web server application according experiments thread provides good performance great scalability web server based thread becomes best performance user mode web server windows
quantum key distribution schemes real random number generators required sides preparation measurement bases choice paper via entangled photon pairs present side channel passive quantum key distribution scheme random number generator unneeded receiver side sender alice side along massive signal photons small amount uninformative photons randomly sent partner bob eavesdropper presence testing error estimation side channel without using random number generator bob actively measure income signals randomly two non orthogonal bases instead passively register photon click events two settled symmetric bases raw key click events probable outcomes special quantum measurement module constructed alice bob security analysis formulas security bounds scheme also investigated reasonable assumptions work shows uninformative state employed paper powerful fight eavesdropper eve
persons blood pressure rises slowly late sleep increases rapidly upon morning awakening commencement diurnal activity exhibits two morning afternoon early evening daytime peaks shows minor midday nadir undergoes decline nighttime sleep systolic somewhat lesser amount diastolic relative wake time means nyctohemeral cycles ambient temperature light noise behaviorally driven temporal patterns food liquid salt stimulant consumption mental emotional stress posture physical activity intensity plus circadian rhythms wake sleep pineal gland melatonin synthesis autonomic central nervous hypothalamic pituitary adrenal hypothalamic pituitary thyroid renin angiotensin aldosterone renal hemodynamic endothelial vasoactive peptide opioid systems constitute key regulators determinants profile environmental behavioral cycles believed far influential circadian ones however facts pattern secondary hypertension diabetes renal disease characterized absence fall sleep scheduling conventional long acting medications bedtime rather morning results much better hypertension control vascular risk reduction presumably highest drug concentration coincides closely peak key circadian determinants profile indicate endogenous rhythmic influences greater importance previously appreciated elsevier ltd rights reserved
multiradio multichannel networks significantly expanded network resource space many existing scheduling routing algorithms rely link based network model apply different heuristics algorithm design achieve approximate throughput optimality paper using tuple based multidimensional conflict graph model establish cross layer framework facilitates systematically studying distributed scheduling routing multihop multipath networks framework tuple link installed routing controller feeds controlled amounts data tuple link output queues scheduling transmission rigorously prove set certain conditions network queue stable mean sense distributed maximal scheduling policy based lyapunov optimization propose distributed delay aware multipath routing method aims minimizing end end delay commodity flow extensive simulation results demonstrate proposed joint scheduling routing algorithm outperforms existing link based single path multipath algorithms tuple based cross layer control algorithm
novel forms social internet things mobile user within communication range may help routing messages another user network resulting message delivery rate depends users mobility patterns message load network new type configuration however poses new challenges security amongst assessing effect group colluding malicious participants global message delivery rate network far trivial work modeling question optimization problem able find quite interesting results coupling network simulator evolutionary algorithm chosen algorithm specifically designed solve problems whose solutions decomposed parts sharing structure demonstrate effectiveness proposed approach two medium sized delay tolerant networks realistically simulated urban contexts two cities different route topology venice san francisco experiments methodology produces attack patterns greatly lower network performance respect previous studies subject evolutionary core able exploit specific weaknesses target configuration elsevier rights reserved
october centers medicare medicaid services began reducing medicare payments bottom performing quartile hospitals hospital acquired condition reduction program hacrp tight clustering hacrp scores around penalty threshold observed resulting hospitals susceptible shift penalty status related single decile changes ranking one complication infection measures used compute hacrp score hacrp score also found significantly correlated several hospital characteristics including hospital case mix index correlation confirmed alternative method measuring hospital complication performance used sensitivity hacrp penalties small changes performance correlation hacrp score hospital characteristics call question validity hacrp measure method risk adjustment
october international safeguards children sport launched safeguards developed implemented evaluated based pilot process took place preceding years throughout piloting phase range qualitative techniques employed capture experiences people within organizations working toward international safeguards participant organizations varied based geographical focus local national international well mission participation competition sport development based thematic analysis eight key pillars identified systems safeguard children built known children pillars cultural sensitivity holistic incentives leadership dynamic resources engagement networks illustrative examples provided future directions project discussed
order capitalise new opportunities advance contraceptive reproductive health choices globally organisations working fields need overcome six institutional obstacles committee management medicalisation iii fear risk controversy conferences meetings symposia obsession coordination fear sex reproductive health community require energy innovative approaches sharp focus service delivery address hurdles otherwise slow misdirect programmatic momentum
order describe accidents work hospital northern portugal analyze main impact period conducted retrospective cross sectional study information obtained notification records accidents work workers highest prevalence levels accidents referred superior health technician female workers age group years secondary education degree working shifts patient services needle pricks main cause hands main injury location wounds frequent type injury followed sprains strains total resulted absence work sprains strains main reason preventive strategies adopted aiming promote workers health
order develop successfully implement cost effective ground treatment design railway embankment traversing soft alluvium deposits high speed train fully instrumented trial embankment carried tokai state kedah malaysia verification design cost effective ground treatment prefabricated vertical drain pvd temporary surcharging geotextile basal reinforcement widely adopted long railway embankment designed meet stringent performance requirements back analyses using finite element modeling fem fully instrumented trial embankment performance ground treatment evaluated verified additional fem analyses carried develop construction control chart used construction allow high embankments built without compromising stability construction meet tight construction schedule technical requirements paper present fem back analyses results fully instrumented trial embankment construction control chart developed together pre planned action plan construction
order develop thermal management high power leds automatic cooling device firstly integrated microcontroller heat pipes fan according experimental results found substrate temperature high power leds could controlled automatically could kept relative low range protect leds contributes better performance longer lifetime led numerical model cooling system established effectiveness verified experimental results simulation results show led junction temperature maintained suitable range thus thermal resistances heat sink ambient led chip ambient cooling system degrees degrees respectively addition increasing number heat pipes cooling fins effective method improve heat transfer cooling system proposed cooling system whose total power consumption less promising tool heat dissipation high power leds elsevier ltd rights reserved
order enhance exhaust waste heat recovery efficiency automotive exhaust based thermoelectric generator teg system three segment heat exchanger folded shaped internal structure teg system investigated study major effect factors performance teg system surface temperature thermal uniformity heat exchanger analyzed research pressure drop along heat exchanger also considered based computational fluid dynamics simulations temperature distribution pressure drop along heat exchanger obtained considering variable length thickness folded plates segment heat exchanger response surface methodology optimization multi objective genetic algorithm applied surface temperature thermal uniformity pressure drop folded shaped heat exchanger optimum design based optimization proposed improve overall performance teg system performance optimized heat exchanger different engine conditions discussed
order enhancement stealth capability ship electric fields similar characters ship electric magnetic fields produce mechanism studied similar effect characters battle effectiveness ship electric magnetic fields analyzed communicate theory ship electric magnetic fields researched similar characters analytical methods stealth technology strategy ship electric magnetic fields discussed shown stealth technology ship electric magnetic fields similar research developed methods experimentation
order extend utilization bamboo green building material new type lightweight section bamboo steel composite beam consisted two pieces cold formed thin walled steel channel three pieces bamboo plywood laths adhesive bonding developed mechanical properties investigated results showed bamboo plywood cold formed thin walled steel channel could form good integrated composite cross section failure modes bearing capacities deformation characteristics composite beams associated flange thickness bamboo plywood thickness cold formed steel channel whole sectional dimension furthermore simplified mechanical model calculation method proposed based superposition principle predicted deformation bearing capacity matched well experimental results indicate bamboo plywood used modern structural material elsevier ltd rights reserved
order help students beginners industrial engineering learn disciplinal definition industrial engineering choose progressional directions paper review developing situation disciplinal definition industrial engineering todevelop disciplinal definition industrial engineering set course system industrial engineering based comprehension industrial engineering experience factories comes authors long term teaching practice finally disciplinal definition industrial engineering described administrative skill system adopts engineering viewpoint plan form optimize various schemes social organization activities establish maintain improve various system social organization achieve operating targets social organization raise benefit efficiency incessantly disciplinal course system include human machinery engineering manufacturing engineering administrative engineering information engineering specialized engineering
order improve dynamic performance signal tracking accuracy electric load simulator influence moment inertia stiffness friction gaps factors system performance analyzed basis researching working principle load simulator paper pid controller based wavelet neural network used achieve friction nonlinear compensation gap inverse model used compensate gap nonlinear compensation results simulated matlab software shown follow performance sine response curve system became better compensating track error significantly reduced accuracy improved greatly system dynamic performance improved
order improve dynamic performance converter transient hysteresis current control strategy proposed based parallel computing combinational logic making comparison real time inductor current threshold inductor current switch controlled accurately matlab simulink environment process buck boost converter simulated simulation results show transient hysteresis current control strategy effectively overcome disadvantages load changes input voltage disturbance occurs posses high load regulation short dynamic response time verifies feasibility proposed strategy
order improve fault monitoring performance grounding electrode lines ultra high voltage uhvdc transmission systems novel fault monitoring approach based high frequency voltage standing wave ratio vswr proposed paper vswr defined considering lossless transmission line characteristics vswr different conditions analyzed shown vswr equals terminal resistance completely matches characteristic impedance line short circuit fault occurs grounding electrode line vswr greater vswr approach positive infinity metallic earth fault conditions whereas vswr non metallic earth faults smaller based analytical results fault supervision criterion formulated effectiveness proposed vswr based fault supervision technique verified typical uhvdc project established power systems computer aided design electromagnetic transients including pscad emtdc simulation results indicate proposed strategy reliably identify grounding electrode line fault strong anti fault resistance capability
order improve performances urea formaldehyde resin adhesive reduce formaldehyde emission isocyanate applied modify resin adhesive effects composition ratio isocyanate resin thermal stability molecular structure composite adhesive investigated fourier transform infrared spectroscopy ray photoelectron spectroscopy thermogravimetric analyzer results showed appropriate addition isocyanate resin favorable improve performances composite adhesive due chemical cross linking reaction isocyanate furthermore reaction mechanism resin adhesive isocyanate analyzed detail research results applied aid materials engineering design development new adhesive quality assurance characterization assessment durability
order improve possibility successful bonding performance structures new method multi depth silicon etching required paper aims design create new method one time multi depth silicon etching manufacturing complex structures based sio masking layer core idea method firstly patterns transferred photo resist photo etching etch pattern transferred sio masking layer multi time shallow etching different time etching control finally patterns transferred silicon wafer uniform ratio based measured etching selectivity sio one time experiments process completed silicon wafer sio masking layer whose thickness elaborately designed firstly etching rate sio etching selectivity sio measured accurately secondly shallow structure based designed structure etching rate sio etching selectivity sio etched sio masking layer second step forms different thickness version sio masking layer last sio masking layer etched final structure consequently different depth groove accomplish due various thickness sio etched previous step experimental results indicated new methods least three advantages compared traditional method faster efficiency higher cleanness complex structure fast work efficiency owes etching rather two gases reduce half time also high cleanness comes exposed air researchers directly largest benefit new method may create complex structure higher required machine design higher mechanical function normal etching method could build different depth grooves due multi process limitation contrary normal one new method create different depth groove different depth groove means complex structure designed
order investigate characteristics vibration windvehicle bridge wvb coupling system two trains meeting dynamic response wvb system analyzed two trains meeting large span suspension bridge using self developed software bansys particularly aerodynamic coefficients bridge two trains meeting determined wind tunnel tests shown wind loads responses leeward vehicle change abruptly meeting process compared case single train responses leeward vehicle increase growing wind speed vehicle speed decrease enlarging lateral distance two trains processes two trains meeting control factors wvb coupling system
order maximize performance internal combustion engine combustion phase usually controlled track desired reference however suffering cyclic variability combustion difficulty meaningful control mean combustion phase constrain variance combustion phase indicator location peak pressure lpp utilized real time combustion phase control research purpose proposed method ensure mean lpp statistically tracks reference constrains standard deviation lpp distribution achieve lpp first calculated based cylinder pressure sensor characteristics analyzed steady state operating condition distribution lpp examined online using hypothesis test criterion basis presented statistical algorithm current mean lpp applied feedback channel designing spark advance adjustment law stability closed loop system theoretically ensured according steady statistical model finally proposed strategy verified spark ignition gasoline engine published elsevier ltd
order meet development advanced manufacturing technology based requirement engineering training colleges new period advanced manufacturing engineering training platform established paper authors introduce details framework function analyze run platform sum application numerical control manufacturing practice
order optimize cost construction engineers always lookout efficient light roofing requires minimum maintenance labor install coir green building material potential raw material production roofing materials like corrugated sheets tiles main objective paper produce cost effective roofing tiles without compromising quality replacing cement using coir fibre basis results composite fibre volume considered optimum composite comparison material costs indicated composite tile substantially cheaper ordinary cement concrete tile published elsevier ltd
order realize light weight high strength anti fatigue sports bicycle carbon fiber used predominant material high grade sports bicycle manufacturing engineering quality detection device studied ensure manufacturing quality riding safety carbon fiber sports bicycle hydraulic servo control system modular fixtures developed paper former realize double close loop control improve testing accuracy device latter realize variety works tested testing bench improve testing efficiency device
order realize collection monitoring remote environmental information system uses discrete component design wireless transceiver module bidirectional data transmission use microcontroller control data processing chip realizes multi computer communication mutual transmission environmental data corresponding encoding decoding algorithm system hardware software design implementation explained details flow chart also presented authors published elsevier ltd
order realize human body temperature fast non contact measurement infrared thermometer designed infrared human body temperature sensor mainly used convert human body infrared voltage signal operational amplifier amplify signal filter circuit filter signal analog signal digital signal conversion circuit data processing mcu lcd display voice reporting body temperature time human body non contact measurement realized experimental results show device realize temperature time acquisition measurement error degrees voice broadcast liquid crystal display temperature time overrun alarm functions
order realize non connect measurement power character jamming bomb carried research power measurement device jamming bomb based infrared radiation first power infrared radiant band jamming bomb summarized refined ensuring feature power jamming bomb characterized magnitude infrared radiation afterwards based theory power measurement device infrared radiation simulated developed including selection detector detector application design analog signal processing digital signal processing using correlation measurement method detect calculate power device finally specific method advantage device introduced results experiment show response time device less detection sensitivity better root device successfully accomplished accuracy measurement infrared radiation wavelength higher detection sensitivity lower response time
order reduce security risk commercial aircraft passengers allowed take certain items carry baggage reason human operators trained detect prohibited items using manually controlled baggage screening process paper use automated method based multiple ray views proposed recognise certain regular objects highly defined shapes sizes method consists two steps monocular analysis obtain possible detections view sequence multiple view analysis recognise objects interest using matching views search matching candidates efficiently performed using look table computed offline order illustrate effectiveness proposed method experimental results recognising regular objects clips springs razor blades pencil cases shown achieving high precision recall objects believe would possible design automated aid target detection task using proposed algorithm
order satisfy high accuracy high security requirements time synchronization smart grid paper conducted research high precision time synchronization control algorithm based ieee protocol slave clock model built considering phase offset frequency drift novel approach using proportional integral derivative pid controller cooperation wolf colony algorithm wca proposed eliminate offset slave clock respect master clock new swarm intelligence algorithm wca introduced self tuning optimal parameters pid controller simulates intelligent predatory behaviors prey distribution rule wolf colony wca based pid control approach compared method based standard particle swarm optimization pso back propagation neural network experimental results show proposed wca based pid control approach time synchronization smart grid higher precision adaptively adjust compensation keep master slave clock synchronization effectively elsevier ltd rights reserved
order solve problem embedding watermark quantum color image paper improved scheme using small scale quantum circuits color scrambling proposed color carrier image colorwatermark image represented using novel enhanced quantum representation image sizes carrier watermark assumed respectively first color pixels watermark image scrambled using controlled rotation gates scrambled watermark image size qubit gray scale expanded image image size qubit gray scale finally expanded watermark image embedded carrier image controlled gates extraction watermark reverse process embedding carrier image achieved applying operations reverse order simulation based experimental results show proposed scheme superior similar algorithms terms three items visual quality scrambling effect watermark image noise resistibility
order study mechanical properties steel tubular columns filled steel reinforced high strength concrete stsrhc eccentric compression paper establishes formula bearing capacity analyzes effect eccentricity slenderness ratio strength materials factors bending column mechanical properties finite element analysis software establish bearing capacity formula regression analysis data results reveal calculation results based software agree well experimental data eccentricity slenderness ratio large influence mechanical properties eccentric compression members strength materials shape steel section small impact calculation results based formula bearing capacity eccentric compression agree well experimental results conclusions possess certain instructional significance design new columns
research use rigid body dynamics optimal control methods generate whole body walking motions dynamics modeling computation created rbdl rigid body dynamics library self contained free open source software package implements state art dynamics algorithms including external contacts collision impacts based featherstone spatial algebra notation implemented using highly efficient data structures exploit sparsities spatial operators library contains various helper methods compute quantities point velocities accelerations jacobians angular linear momentum others concise programming interface minimal dependencies makes suitable integration existing frameworks demonstrate performance comparing state art dynamics libraries based recursive evaluations symbolic code generation
research simulation model driven engineering manufacturing cell smde proposed purposes smde support manufacturing engineering processes based simulation model extend range control applications simulation applications using based control smde provides simulation model controls monitors manufacturing cell directly using based control manufacturing system execution phase simulation model acts response behaviors manufacturing system controlled synchronizing simulation model behaviors manufacturing system implementation phase simulation model mixed synchronized real equipment real controllers management applications condition parts equipment control programs manufacturing management applications provided manufacturing system
parkinson disease dopamine depletion causes major changes brain resulting typical cardinal motor features disease neuropathology restricted postmortem examinations limited single time progression models dopamine tone brain chemically physically disrupted valuable tools understanding mechanisms disease basal ganglia well studied context circuit changes response dopamine loss linked motor dysfunctions however etiology cognitive dysfunctions comorbid patients remained unclear article review recent studies exploring dopamine depletion affects motor cortex synaptic level particular highlight recent findings abnormal spine dynamics motor cortex mouse models vivo time lapse imaging motor skill behavior assays combination previous studies role motor cortex skill learning impairment ability loss dopamine becoming apparent taken together conclude discussion potential role motor cortex possibility targeting motor cortex future therapeutics international parkinson movement disorder society
patients insufficient weight loss sleeve gastrectomy super obese individuals among many surgical options available single anastomosis duodeno ileal bypass sadi sadi could considered due limited information available use sadi second step procedure objective study evaluate mid term results responsiveness sadi sleeve gastrectomy present prospective data consecutive patients mean bmi mean excess weight mean excess weight loss ewl submitted sadi second step revisional procedure intraoperative complications four early complications occurred within first postoperative hours six month follow number patients available respectively percent total weight loss time revision months sadi global ewl complete remission rate diabetes dyslipidemia hypertension respectively sadi three patients required revisional surgery due hypoalbuminemia sadi second step strategy super obese patients failed offers satisfactory ponderal weight loss acceptable comorbidities resolution however risk severe malnutrition distal sadi makes necessary careful patient selection
photovoltaic systems maximum power point tracking mppt indispensable task date various mppt techniques proposed literature using classical artificial intelligence methods however techniques tested different systems different environmental conditions work attempt summarize give comprehensive comparative study adopted artificial intelligence based mppt techniques mppt techniques described based proportional integral derivative pid fuzzy logic artificial neural network ann genetic algorithms particle swarm optimization pso developed mppt controllers tested weather profile photovoltaic system composed module buck boost converter load initially modelling simulation system performed using matlab simulink environment thereafter sliding mode control applied converter order improve performance stage different steps development mppt technique presented simulation performed confirm validity proposed controllers variable temperature solar irradiance conditions finally comparative study carried iri order evaluate developed techniques regarding two principal criteria performance implementation cost performance evaluated using comparative analysis tracking speed average tracking error variance efficiency estimate implementation cost classification carried according type used sensors type circuitry software level complexity recommendations expected useful researchers mppt area validity mppt technique given last section
polar seas seasonal melting ice triggers development open water ecosystem characterized short lived algal blooms grazing development zooplankton influx avian mammalian predators spatial heterogeneity timing ice melt generates temporal variability development events across habitat offering natural framework assess foraging marine predators respond spring phenology combined tracking data antarctic petrels thalassoica antarctica synoptic remote sensing data sea ice chlorophyll test development melting ice primary production drive antarctic petrel foraging cross correlation analyses first passage time revealed antarctic petrels utilized foraging areas spatial scale areas changed position disappeared within showed spatial consistency among years generalized additive model gam analyses suggested presence foraging areas related time since ice melt antarctic petrels concentrated search effort melting areas areas reached age date ice melt found significant relationship search effort chlorophyll concentration suggest foraging patterns related vertical distribution profitability main prey antarctic krill euphausia superba study demonstrates annual ice melt southern ocean shapes development highly patchy elusive food web underscoring importance flexible foraging strategies among top predators
preparation world health organization development eleventh revision international classification diseases related health problems icd chapter mental behavioral disorders article reviews literature pertaining severe irritability child adolescent psychopathology first research severe mood dysregulation suggests youth irritability temper outbursts among features hyperactivity arousal demonstrate cross sectional correlates developmental outcomes distinguish youth bipolar disorder second evidence points irritable dimension oppositional defiant disorder symptomatology uniquely associated concurrent subsequent internalizing problems contrast diagnostic statistical manual mental disorders disruptive mood dysregulation disorder review literature supports different solution subtype oppositional defiant disorder chronic irritability anger proposal included appendix solution consistent available evidence better fit global public health considerations harm benefit potential clinical utility cross cultural applicability implications assessment treatment research discussed world health organization licensee elsevier ltd rights reserved
present days fundamental concepts techniques signal processing control theory extended towards fractional order systems paper considered family fractional order low pass filters using concepts fractional order calculus approximated upto satisfactory level took approximated transfer functions realised using operational amplifiers passive components resistors capacitors resistors approximated switched capacitor arrangements switched capacitor based filters simulated orcad pspice platform results matched corresponding theoretical responses simulated matlab broad purpose work propose novel technique design fractional order filters used discrete time analog signal processing applications control applications goal behind using arrangements make integration analog digital functions possible single chip
present paper would like share experiences building new education sports technology mid sweden university results years successfully running ostersund sports technology education mid sweden university started campus ostersund part curriculum engineering department specialization initially three year bachelor level later extended additional two year master level aiming quality sports technology education three keystones underlying process representing solid knowledge base capacity flexible problem solving use innovative approaches department unites researches background natural sciences engineering disciplines wide experience working within industry equally active research teaching unique constellation profiles forming department include sportstech group backbone also ecology eco technology quality technology groups bringing excellence extra competence needed assure quality sports technology education first higher education institution sweden give kind education program swedish universities followed success measured number graduates taking good jobs industry also enjoy steady flow new students coming parts sweden sports technology education stays among desirable ones country authors published elsevier ltd selection peer review responsibility school aerospace mechanical manufacturing engineering rmit university
pre surgery decisions hospital emergency cases fast reliable results solid fluid mechanics problems great interest clinicians current investigation iterative process based pressure type boundary condition proposed order reduce computational costs blood flow simulations arteries without losing control important clinical parameters incorporation cardiovascular autoregulation together well known impedance boundary condition forms basis proposed methodology autoregulation instabilities associated conventional pressure type impedance boundary conditions avoided without excessive increase computational costs general behaviour pulsatile blood flow arteries important clinical point view well reproduced new methodology addition interaction blood arterial walls occurs via modified weak coupling makes simulation stable computationally efficient based vitro experiments hyperelastic behaviour wall characterised modelled applications benefits proposed pressure type boundary condition shown model idealised aortic arch without ascending aorta dissection common cardiovascular disorder
prisons prevalence mental disorders death suicide reach proportions far general population risk suicide times higher based sample newly incarcerated individuals relationship suicide attempts mental disorders studied emphasis attention deficit hyperactivity disorder adhd results show possible presence adhd prisoner increases likelihood already attempted suicide well presence axis disorders
rats spreading depolarization induces vasodilation hyperemia naive tissue inverse response artificial cerebrospinal fluid topically applied brain containing nitric oxide lowering agent elevated inverse response characterized severe vasoconstriction ischemia perfusion deficit runs together depolarization tissue spreading ischemia found male wistar rats pre treatment artificial cerebrospinal fluid containing elevated invivo led selective decline alpha alpha atpase activity determined spectrophotometrically vivo moreover spreading ischemia recorded laser doppler flowmetry electrocorticography resulted artificial cerebrospinal fluid containing nitric oxide lowering agent combination atpase inhibitor ouabain concentration selectively inhibiting alpha alpha activity decline alpha alpha activity results increased uptake internal stores astrocytes vascular myocytes pericytes since outflux via plasmalemmal exchanger declines augmented mobilization internal stores spreading depolarization might enhance vasoconstriction thus contributing spreading ischemia accordingly spreading ischemia significantly shortened intracellular stores emptied pre treatment thapsigargin inhibitor sarco endo plasmic reticulum atpase serca findings might relevance clinical conditions spreading ischemia occurs delayed cerebral ischemia subarachnoid hemorrhage
recent decades china facing serious water pollution crises address problem discharge standards wastewater treatment plants china becoming stringent also sewage charge compliant emissions penalty rate non compliant emissions increased significantly paper comprehensively investigates economic environmental implications wastewater management policy china paper general framework analysis wwtps behavior resulted economic environmental consequences presented impacts discharge standard charge rate penalty rate analyzed trade offs operational cost environmental impact pollutant emissions identified study also provides insightful management implications concerned policy makers elsevier ltd rights reserved
recent years systematic evaluation university courses become common germany statistical sociological psychological aspects quite thoroughly explored little linguistic research kind evaluation paper endeavour present basis speech act model judgement fundamental problems connected evaluation teaching university courses linguistic point view done reasons explained detail paper form strictly linguistic model way popular scientific argumentation
recent years smart structures experienced significant popularity civil engineering structures referred intelligent structures built combination smart conventional materials intelligent systems gather information perform tasks also sense variation conditions materials adapt accordingly conductive hot mix asphalt hma mixtures constructed modifying electrically conductive materials conductive hma mixtures would potentially make many technologies applicable pavements including limited thermal electric icing airport runways highways cathodic protection concrete bridge decks pavement damage sensing truck weigh motion forth dispersing carbon nanofibers cnf hma mixtures makes smart material develops piezoresistive effect main objective study develop smart hma mixture using electrically conductive material carbon nanofibers cnf cnf modified hma mixtures would ability respond loading exploratory investigation piezoresistive response cnf modified hma mixtures various types loading frequencies temperatures evaluated stress strain response due applied load relationship change resistivity discussed found two type cnf used study one provide better piezoresistive response hma determined embedment copper wire electrodes effective method achieve smooth consistent electrical response furthermore polymer modified binders showed promising piezoresistive effect medium high temperature range elsevier ltd rights reserved
recent years amorphous alloys received considerable attraction physical mechanical magnetic properties alloy system good soft magnetic properties high magnetic saturation high curie point makes suitable high temperature magnetic applications paper effect different elements glass forming ability gfa system evaluated based meidema semi empirical model results compared mechanical alloying experiments seem good elements added alloys respect thermodynamics kinetics requirements calculations based extended miedema model showed enthalpy gibbs free energy changes solid state amorphisation fecosibp mol mol respectively experiments three different routes lead amorphisation system also comparison melt spinning techniques showed gfa techniques completely different elsevier rights reserved
recent years compressed sensing received considerable attention signal processing community ability represent sparse signals number samples much less required nyquist sampling theorem minimization powerful tool sparse signal reconstruction measured samples computational complexity burden real applications recently number greedy algorithms based orthogonal matching pursuit omp proposed near minimization performance much less processing time work new omp type two stage sparse signal reconstruction algorithm namely data driven forward backward pursuit fbp proposed based former work called forward backward pursuit fbp fbp iteratively expands shrinks estimated support set constitute forward backward stages fbp unlike fbp forward backward step sizes constants dependent correlation projection values respectively calculated iteration recovery performance using noiseless noisy sparse signal ensembles well natural sparse image indicates fbp surpasses methods terms success rate processing time
recent years deep neural networks dnn demonstrated significant business impact large scale analysis classification tasks speech recognition visual object detection pattern extraction etc training large dnns however universally considered time consuming computationally intensive task demands datacenter scale computational resources recruited many days propose concept resistive processing unit rpu devices potentially accelerate dnn training orders magnitude using much less power proposed rpu device store update weight values locally thus minimizing data movement training allowing fully exploit locality parallelism training algorithm evaluate effect various rpu device features non idealities system parameters performance order derive device system level specifications implementation accelerator chip dnn training realistic cmos compatible technology large dnns billion weights massively parallel rpu architecture achieve acceleration factors compared state art microprocessors providing power efficiency gigaops problems currently require days training datacenter size cluster thousands machines addressed within hours single rpu accelerator system consisting cluster rpu accelerators able tackle big data problems trillions parameters impossible address today like example natural speech recognition translation world languages real time analytics large streams business scientific data integration analysis multimodal sensory data flows massive number iot internet things sensors
recent years due mass retirement skilled workers loss expertise emerged problem japan meanwhile performance computer hardware drastically improving skill based pid controllers utilizing database proposed potential solution problem however controllers may respond multiple demands control performance users controller considered evaluation users solution problem expert controller based skilled worker operating information control performance assessments proposed according method data pid parameters estimated using operating data evaluation values skill skilled worker stored database information vectors high scores selected local pid controller designed response user requirements conventional research least squares method applied estimating pid parameters operating data skilled worker restrictions values risks loss physical meanings pid parameters case negative values research expert controller using particle swarm optimization pso proposed method data obtained human control control simulator constructed computer used estimate human skill pid parameters moreover providing restrictions estimation pid parameters enables preserve physical meanings research effectiveness proposed expert controller verified using control simulator
recent years machine learning research gained momentum new developments field deep learning allow multiple levels abstraction starting supersede well known powerful tree based techniques mainly operating original feature space methods applied various fields including finance paper implements analyzes effectiveness deep neural networks dnn gradient boosted trees gbt random forests raf several ensembles methods context statistical arbitrage model trained lagged returns stocks elimination survivor bias daily one day ahead trading signals generated based probability forecast stock outperform general market highest probabilities converted long lowest probabilities short positions thus censoring less certain middle part ranking empirical findings promising simple equal weighted ensemble ens consisting one deep neural network one gradient boosted tree one random forest produces sample returns exceeding percent per day prior transaction costs irrespective fact profits declining recent years findings pose severe challenge semi strong form market efficiency elsevier rights reserved
recent years measurements total electron content tec gained importance increasing demand gps based navigation applications trans ionospheric communications study variation ionospheric tec used data obtained gps ionospheric scintillation tec monitoring gistm system operation svnit surat india degrees degrees located northern crest equatorial anomaly region data collected low sunspot activity period august december used study diurnal monthly seasonal semi annual annual variations tec surat observed diurnal variation region reaches maximum value ist monthly average diurnal variations showed tec maximizes equinox months followed winter months lowest summer months ionospheric range delay tec primary gps signal per tecu diurnal variation tec shows minimum maximum variation tecu current low sunspot activity periods tec values correspond range delay variations surat variations range delay certainly increase high sunspot activity periods detected tec variations also closely related space weather characterizing quantities solar wind geomagnetic activity indices
recent years new control approaches emerged replace augment conventional control engineering methods paper presents design verification comparison two advanced methods imc mpc applied control dynamic processes complex dynamics development advanced control methods based robustness optimality prediction important challenging task presented methods guarantee robust stability high performance manipulator control
recent years researchers trying shed light gaming addiction association different psychiatric disorders psychological determinants latest edition version american psychiatric association diagnostic statistical manual mental disorders fifth edition dsm included section internet gaming disorder igd condition empirical study proposed nine criteria diagnosis igd item internet gaming disorder igd test developed valid reliable tool assess gaming addiction based nine criteria set dsm aim study validate arabic version igd test arabic version igd help identifying arabic speaking pathological gamers also stimulate cross cultural studies could contribute area need research insight treatment process translation back translation participation sizable sample arabic speaking adolescents present study conducted psychometric validation igd test confirmatory factor analysis showed validity arabic version igd test one factor model arabic igd test good psychometric properties fitted sample data extremely well addition correlation analysis igd test daily duration weekdays weekends gameplay revealed significant positive relationships warranted criterion related validation thus arabic version igd test valid reliable measure igd among arabic speaking populations
recent years researches focus addressing query bottleneck issue big data nosql databases mapreduce big data processing framework although nosql databases many advantages line analytical processing olap big project migrate relational database management system rdbms nosql therefore optimization rdbms still important paper construct column access aware stream data cache caidc relational databases integral part rdbms memory cache furthermore live synchronization approach physical rdbms memory data cache using stream processing framework proposed one hand caidc provides low latency supporting log based trigger presence updates maintain data consistency stream processing framework hand caidc translates frequently accessed data column oriented memory cache column access frequency ensure heavy hitter queries finally experimental results show approach supporting wide range applications big data
recent years resource constrained hardware makes operating system simplicity crucial design criterion majority research operating systems focused reactive nature event driven kernel however event based kernel may result latency processing events erroneous energy profiling battery driven wireless sensor nodes use radio event wake sleeping nodes radio always consumes energy components transmission intervals contribution paper present exos timer driven operating system process periodic events time obtain rapid responses external signals system kernel easily ported memory constrained target platforms exos able provide detailed prediction component energy consumption program execution evaluation demonstrated exos practically integrated wireless sensor networks elsevier ltd rights reserved
recent years sand filled geotextile bags geobags become popular means long term riverbank protection however associated failure mechanisms geobag revetments still well understood three interactions influence geobag performance namely geobag geobag geobag water flow geobag water flow riverbank interactions enhance fundamental understanding performance geobags revetment laboratory experimental program undertaken using fixed bed mobile sediment bed experimental study bags used construct geobag revetments failure modes observed two bed configurations general common trends bed configurations uplifting turbulent bursting induced flow revetment voids overtopping pulling internal sliding mobile bed case toe scouring significant negative influence geobag performance extend laboratory measured hydraulic parameters conveyance estimation system ces used ces model validated fixed bed experimental observations validated model used predict mobile bed formations ces bed predictions used produce failure diagram geobag water flow interactions classification bed formation geobag water flow riverbank interactions concluded ces useful computationally efficient tool prediction hydraulic parameters bed formations next phase research observations experimental program used validate discrete element model geobag revetment used help develop much needed geobag revetment design guidance american society civil engineers
recent years technology includes informatization automation introduced construction field hand field still require human operation technology based experience skills various environmental conditions vary hour hour seasoned technicians made operation technology effective various sites established skillful techniques however decreasing number aging skilled technicians social issue making skill tradition development younger technicians difficult operation sites require skillful techniques study assumed operation machines operator synonymous control systems controller human operation techniques considered viewpoint control engineering regarding operator controller control system used represent operator consisted proportional integral derivative pid controller cerebellar model articulation controller cmac adjusted pid gains cmac type neural network learns human skills variations pid gains expresses based variations study applies proposed method hydraulic excavator swing operation evaluate skills moreover difference operation skills excavator clarified obtaining operation data skilled younger technicians examining variation tendency pid gains
recent years development high techniques field computer graphics computer vision images processing widely studied applied geometric modeling especially field modeling reconstruction object images one researches field medical image processing invested developed researchers computer science medicine paper presents survey research construction reconstruction object set medical images first review existing methods building object medical image slices dicom digital imaging communications medicine format come measurement devices medicine like ray computerized tomography ray magnetic resonance imaging mri etc thereafter construct application based vtk library building visualizing handling object scanned slices application support medical staffs doctors diagnostic treatment patients
recent years hegemony traditional relational database management systems rdbmss declined favour non relational databases nosql database technologies better adapted meet requirements large scale web infrastructures handling big data providing elastic horizontal scalability nosql technology however suited specific use cases data models consequence nosql adopters faced tremendous heterogeneity terms data models database capabilities application programming interfaces apis opting specific nosql database poses immediate problem vendor technology lock solution proposed shape object nosql database mappers ondms provide uniform abstraction interface different nosql technologies ondms however come cost increased performance overhead may significant economic impact especially large distributed setups involving massive volumes data paper present benchmark study quantifying comparing performance overhead introduced object nosql database mappers create read update search operations benchmarks involve five promising industry ready ondms impetus kundera apache gora eclipselink datanucleus hibernate ogm executed single node node cluster setup main findings summarised follows introduced overhead substantial database operations memory however disk operations high network latency result negligible overhead found fundamental mismatches standardised ondm apis technical capabilities nosql database iii search performance overhead increases linearly number results datanucleus hibernate ogm search overhead exceptionally high comparison ondms
recent years mini mental state examination mmse widely used proposed cognitive decline screening framework systematic geriatric evaluation health centers aim present longitudinal study identify potential determinants mmse score evolution year period population aged sixty years good general health without dementia consulting health check longitudinal study preventive medical center cmp nancy subjects years age mean age years included senior health examination study subjects underwent visits period years mmse measurement self administered questionnaire emotional psychological state evaluated baseline follow visit major components total variance baseline mmse represented education level practice regular physical activity nervousness despair multivariate analysis identified variables baseline visit independently predicted annual changes mmse mmse score education level difficulty social relations respectively education level several psychological factors may influence mmse score evolution time community dwelling subjects aged years without dementia subjects low mmse score predict cognitive decline period years therefore reliability mmse type population questionable
recent years study shear strength soil geosynthetics caught attention scholars study changing traditional geogrid structure adding polymeric anchors reinforcement grid naming grid anchor sought experimentally analyze performance new system increasing coefficient interaction ratio direct shear cirds achieve large scale direct shear tests conducted typical geogrid system results showed cirds average times greater words interaction soil reinforcement system increases almost compared typical geogrid regarding direct shear mechanism elsevier ltd rights reserved
recent years technological advancements led deluge data distinctive domains need development solutions based parallel distributed computing still long way research development massive computing frameworks continuously growing particular stage highlighting potential research area along key insights could asset researchers field therefore paper explores one emerging distributed computing frameworks apache hama top level project apache software foundation based bulk synchronous parallel model present unbiased critical interrogation session apache hama conclude research directions order assist interested researchers
recent years validity embolism quantification methods questioned especially long vesseled plants studies suggested cutting xylem tension even water might generate artificial cavitation accordingly rehydration procedure prior hydraulic measurements recommended avoid artefact hand concerns raised xylem refilling might occur samples rehydrated explore potential biases affecting embolism quantification grapevine vitis vinifera petioles harvested tension xylem relaxation employ direct visualization embolism ray micro computed tomography microct test occurrence fast refilling artifactually low per cent loss conductivity plc due rehydration prior sample harvest well excision induced embolism artifactually high embolism due air introduction harvest additionally compared response functions stomatal regulation xylem embolism xylem pressure short time aeuro min xylem tension relaxation prior hydraulic measurement resulted lower degree embolism found samples harvested native tensions yielded xylem vulnerability curves similar ones obtained using direct microct visualization much longer periods hydration overnight required xylem refilling observed occur field grown vines stomatal closure occurred less negative required induce plc results demonstrate relaxation xylem tension prior hydraulic measurement allows reliable quantification native embolism grapevine petioles furthermore find stomatal regulation sufficiently conservative avoid transpiration induced cavitation results suggest grapevines evolved strategy cavitation resistance rather one cavitation tolerance diurnal cycles embolism repair
recent years increasing interest adopting synchronous reluctance machines several applications due two main factors first increasing highly variable cost rare earth permanent magnet ndfeb smco second requirement efficient machines respect induction machines general applications however drawback synchronous reluctance machine low power factor drawback compensated assisting machine means proper volume material generally ferrite introduced rotor flux barriers flux saturates rotor iron bridges increases power factor machine corresponds decrease volt ampere ratings inverter adds flux torque component paper investigates select amount ferrite magnet assisted reluctance machine adopting model considers machine operation low speed current flux linkage limit shown means aforementioned analysis machine performance low speed improved means proper choice flux linkage
recent years users ambient intelligence environments overwhelmed huge numbers social media available consequentially users trouble finding social media suited needs help users ambient environment get relevant media tailored interests propose new method adapts katz measure path ensemble based proximity measure use social tagging services model ternary relations among user resource tag weighted undirected tripartite graph apply katz measure graph exploit provide personalized recommendation individual users within ambient intelligence environments experimental evaluations show proposed method improves recommendation performance compared existing algorithms
recent years various stimuli identified capable enhancing neurogenesis process dysfunctional senescent brain neurodegenerative certain neuropsychiatric diseases applications electromagnetic fields brain tissue shown affect cellular properties importance therapies medicine recognized study differentiating murine cortical networks multiwell microelectrode arrays repeatedly exposed extremely low electromagnetic field elemf alternating frequencies piggy backed onto mhz carrier frequency elemf exposure stimulated electrical network activity intensified structure bursts exposure electromagnetic fields within first days vitro differentiation network activity induced also reorganization within burst structure effect already pronounced days vitro days exposure overall development cortical activity conditions accelerated functional electrophysiological changes accompanied morphological ones percentage neurons neuron glia culture increased without affecting total number cells indicating enhancement neurogenesis elemf exposure selectively promoted proliferation particular population neurons evidenced increased proportion gabaergic neurons results support initial hypothesis kind elemf stimulation could treatment option specific indications promising potential cns applications especially degenerative diseases alzheimer disease dementias
recent years witnessed explosion biological data resulting largely demands life science research vast majority data freely available via diverse bioinformatics platforms including relational databases conventional keyword search applications type approach achieved great results last years proved unfeasible information needs combined shared among different scattered sources recent years many data distribution challenges solved adoption semantic web despite evident benefits technology adoption introduced new challenges related migration process existent systems semantic level facilitate transition developed scaleus semantic web migration tool deployed top traditional systems order bring knowledge inference rules query federation existent data targeted biomedical domain web based platform offers single package straightforward data integration semantic web services help developers researchers creation process new semantically enhanced information systems scaleus available open source http bioinformatics github scaleus
recent years china rapid development social economy society requires quality college students college students employment competition essence competition ability employment article analysis ideological political education college students employment ability manufacturing engineering put forward strengthen college students ideological political education improving employment ability manufacturing engineering college students specific methods effective way
repeated games hard distinguish true prosocial behavior strategic behavior particular player know whether reciprocal action intrinsically strategically motivated paper experimentally investigate relationship intrinsic strategic reciprocity running two period repeated trust game strategic treatment subjects know meet twice non strategic treatment know hence second period comes surprise find subjects anticipate strategic reciprocity intrinsic reciprocity rewarded fact total level cooperation trust reciprocated higher non strategic treatment indicates strategic reciprocity crowds intrinsic reciprocity one takes repeated game incentives repeated game one sees cooperation higher social surplus elsevier rights reserved
response palermo australian psychologist press comments aspects target paper elaborated particular given palermo timely emphasis potential social cultural implications research demonstrating beneficial consequences negative affect historical background practical implications experimental evidence elaborated furthermore reviewer also comments applicability alternative theoretical conceptualizations data reported issue also receives attention overall concluded strong convergent evidence often beneficial consequences mild negative affect findings deserve serious consideration practical applications psychology conceptions represents healthy balanced emotional life embracing accepting periods negative affectivity recognised normal healthy part human condition cultural bias towards positive affect tempered appreciation adaptive benefits dysphoria
rotating electrical machine design magnetic equivalent circuit based reluctance network method seems fair tradeoff computational time precision therefore paper deals semi analytical calculation method direct quadrature axis magnetic circuit reluctance synchronous machines rsm means nonlinear reluctance network corresponding non linear equation systems derived forming separated equivalent magnetic networks stator multiple flux barrier rotor divided air gap adaptive interconnection network model air gap needed result relevantly simplifies analysis compared conventional reluctance network calculation one global system however analytical calculation model provides results significantly faster finite element method fem sufficient precision thus suitable first rough design rsm
scientific modelling computation choice appropriate method allocating tasks parallel processing depends computational setting nature computation allocation independent similar computational tasks modelling runs monte carlo trials among nodes heterogeneous computational cluster special case specifically evaluated previously simulation study shows method demand worker initiated pulling bag tasks case leads reliably short makespans computational jobs despite heterogeneity within cluster nodes simple reference implementation programming language message passing interface mpi provided published elsevier ltd
social groups individuals often confronted evaluations behaviour group members motivated adapt behaviour accordingly two studies examine emotional responses towards perceived coping abilities morality competence evaluations individuals receive group members study show evaluations one immoral behaviour primarily induce guilt whereas evaluations incompetent behaviour raise anger study elaborate psychological process associated emotional responses demonstrate evaluations immorality compared incompetence diminish group members perceived coping abilities turn intensifies feelings guilt however anticipating opportunity restore one self image moral group member perceived coping abilities increased experience guilt alleviated together studies demonstrate group members overcome moral misery restoring self image
cases parents caring adult child intellectual developmental disability idd must balance caregiving another family member dual responsibility referred compound caregiving may contribute increased feelings distress change perceived ability care child current study examined compound caregivers differ parents adults idd whether compound caregiving significantly associated family distress data available parents aged years seeking adult services son daughter idd parents completed mailed questionnaire telephone interview indicated compound caregiver responsibilities parents identified compound caregivers compared terms family characteristics well parental perceptions burden mastery family distress measured revised caregiver appraisal scale brief family distress scale respectively nearly half parents reported compound caregivers demographic profile parents different parents children slightly younger compound caregiving significantly associated parental perceptions burden mastery family distress demands outside caring adult child idd negatively influence family functioning must included part caregiving assessments
surgical series cancer free survival years often referred cure recent years attempts improve cure rates non small cell lung cancer nsclc focussed earlier diagnosis cost effective screening programs systemic therapies historically added small benefit overall survival adjuvant palliative setting however last two decades development new treatment options added incremental improvements nsclc survival rates patients targetable sensitising mutation including epidermal growth factor receptor gene mutations anaplastic lymphoma kinase rearrangements significantly better prognosis many survive beyond years immunotherapy effective treatment selected patients nsclc set cause another leap year survival rates although patients free disease survival years may become important end point nsclc becomes seen chronic oncological disease elsevier ltd rights reserved
targeting essential viral rna dependent rna polymerase rdrp nucleotide analogues play major role antiviral therapies flaviviridae family hepatitis virus hcv eradicated chronically infected patients using combination drugs generally include modified uridine analogue sofosbuvir delivered nucleotide prodrug dengue zika viruses emerging flaviviruses whose rdrp closely related hcv yet nucleoside drug clinically approved acute infections purified dengue zika virus full length viral rdrps used assemble stable binary complex made virus specific rna primer templates complex used assess selectivity towards nucleotide analogues bearing modifications position show dengue zika virus rdrps exhibit discrimination pattern nucleoside analogues unlike hcv rdrp presence beneficial rendering discrimination pattern analogues act non obligate rna chain terminators dengue zika nucleotide selectivity towards modified ntps mirrors potency corresponding analogues infected cell cultures
biomass sector technologies like carbonization torrefaction utilized production solid carbonaceous biofuels materials framework manuscript novel method production solid carbonaceous materials introduced defined frictional pyrolysis uses application pressure friction whereas external heat transfer needed propagation process novel method compared torrefaction order assess potential process corn stover strongly bounder water high content deciduous xylan mass balances implemented technologies characterization products done means simultaneous thermal analysis elemental analysis frictionally pyrolyzed corn stover higher recovered mass yield higher recovered energy yield fixed carbon content torrefied corn stover although external energy provided means internal combustion engine net energy content final solid yield contained input energy differential scanning calorimetry analysis showed heating rate regime oxygen rich environment frictionally pyrolyzed corn stover exothermic decomposition torrefied material elsevier ltd rights reserved
central andes argentina degrees snowmelt main source freshwater essential natural resource similar million people adjacent arid lowlands region laguna llancanelo collects water inputs malargue endorheic basin previous studies concerning annual intra annual variations lagoon relationship regional climate rare obtained monthly record laguna llancanelo area lla using modified normalized difference water index derived landsat images monthly lla ranges significantly related variations rio malargue main snow fed tributary lagoon long term relationship lla local rainfall rapid increases lla result heavy rainfall around lagoon conversely rapid reductions lla encompass periods reduced discharge rio malargue low local rainfall lla integrates moisture pacific snowfall upper andes atlantic lowland rainfall origins therefore propose using lla indicator regional water balance
class strictly positive functions strong localization results obtained approximation bernstein max product operators results allow approximate locally bounded strictly positive functions good accuracy potential applications image processing approximation fuzzy numbers useful concepts statistics computer programming engineering especially communications experimental science elsevier inc rights reserved
computer graphics industry great demand cost time effective simulation rendering meeting acceptable level realism hardware based simulation rendering taken another degree low level details environment modelling grandeur peoples paper presents investigation find feasibility deploying crowd degrees panoramic view using mobile platform case study first crowd modelled modifications newtonian laws inclusion proxy agents speed control turning second workability tests experiments carried concerning preferred parameters agent improvement random movements crowd dynamicity capability collision avoidance finally investigation discussed proposed solutions handling crowd degrees panoramic view mobile platform published future academy www futureacademy org
context doubling energy use worldwide remaining carbon energy buildings account total energy consumption appropriate buildings contribute intelligently reduce consumption contribute increase renewable energy production become key node energy grid related energy transport eco city moreover smart buildings near future aggregating huge amount data numerous sensors connected neighbourhood city territory big data analytics cloud computing bring new services inhabitant citizen presenting paper smart building green new building centre eco city grenoble france designed many green ideas living lab supporting research teaching field sustainability paper focusing energy field deals electrical micro grid interaction
context mental disorders sensory overload widely described phenomenon used conjunction psychiatric interventions removal stimuli however theoretical foundation sensory overload addressed literature described insufficient fragmentary date concept sensory overload yet sufficiently specified analyzed aim study analyze concept sensory overload mental health care literature search undertaken using specific electronic databases specific journals websites hand searches specific library catalogues electronic publishing databases walker avant method concept analysis used analyze sources included analysis aspects method walker avant covered concept analysis conceptual understanding become focused defining attributes influencing factors consequences described empirical referents identified concept analysis first step development middle range descriptive theory sensory overload based social scientific stress theoretical approaches specification may serve fundament research development nursing diagnosis guidelines
context optical interferometry undersampled power spectrum bispectrum data accessible poses ill posed inverse problem image recovery recently tri linear model proposed monochromatic imaging leading alternated minimization problem work positivity constraint considered problem solved approximated gauss seidel method paper propose improve approach three fundamental aspects first define estimated image solution regularized minimization problem promoting sparsity fixed dictionary using either weighted regularization term secondly solve resultant non convex minimization problem using block coordinate forward backward algorithm algorithm able deal smooth non smooth functions benefits convergence guarantees even non convex context finally generalize model algorithm hyperspectral case promoting joint sparsity prior regularizationterm present simulation results monochromatic hyperspectral cases validate proposed approach
context ever harsher production conditions encountered oil gas industry need improved materials qualification methods sour environments classic approach based partial pressure adequately characterize corrosive severity particular high pressure environments high pressure high temperature wells paper describes introduction non ideal thermodynamics characterization environmental severity focus sour exposure using fugacity aqueous concentration rather partial pressure experimental work shown approaches valid least sulfide stress corrosion cracking steel benefits demonstrated recommended extend work materials degradation mechanisms also upgrade laboratory test methods industry standards purpose
created anisotropy based control theory sequence gaussian random vectors zero mean certain mean anisotropy level accepted input perturbations acting linear system paper author considers concept mean anisotropy sequence nonzero mean anisotropic norm system given input problems anisotropy based analysis frequency domain state space representation considered difference classical formulas computing mean anisotropy anisotropic norm new formulas shown problem controller design researched
current energy scenario system design operation strategies paramount especially plants fed renewable sources whose production strictly connected users demand systems optimization must consider possibility energy storage conversion among different forms energy paper hybrid cogeneration system composed cogenerative internal combustion engine photovoltaic plant boiler pump turbine investigated different energy storage options included pack batteries water reservoir hot thermal storage applying particle swarm optimization method devices size hourly operation simultaneously optimized minimization overall cost optimization goal main constraint fulfilment user request electricity heat water results show cogenerative internal combustion engine supplies electricity heat winter time summer period supplies electricity heat use pump turbine allows reduce battery discharge rate depth discharge consequent increase battery lifetime elsevier rights reserved
current scenario due global deterioration environment climate change among water pollution possesses serious threat populace waterborne pathogenic bacteria like escherichia coli vibrio cholerae salmonella typhimurium klebsiella pneumoniae etc responsible several diseases diarrhoea cholera salmonellosis etc order overcome waterborne bacterial diseases purification water plants great use potential role ancient times present study deals clinical laboratory standards institute clsi recommended broth microdilution antibacterial susceptibility assay waterborne bacterial pathogens lippia nodiflora petroleum ether lnpe ethanolic extracts lnee prepared leaves flowers together lippia nodiflora verbenaceae comparison camphor growth inhibition tested bacterial pathogens recorded mic values found coli cholerae respectively lnpe extract thus lnpe justifies potential inhibiting growth tested waterborne bacterial pathogens creates interest testing active fraction vivo trials organoleptic analysis making good herbal replacement conventional water treatment
early stages learning computer programming computer science minors share misconception programming order address problem fmas flowchart based multi agent system developed familiarize students prior knowledge programming initial stages learning programming aim improve students problem solving skills introduce basic programming algorithms prior surface structure using automatic text flowchart conversion approach therefore students focus less language syntax designing solutions flowchart development way text flowchart conversion visualization based approach employed fmas engage students flowchart development subsequent programming stages discussed paper finally experimental study devised assess success fmas positive feedback achieved therefore using fmas practice supported results indicate considerable gains experimental group control group results also show automatic text flowchart conversion approach applied fmas successfully motivated nearly participants problem solving activities consequently results suggest additional future development proposed approach form intelligent tutoring system make early stages learning programming encouraging students
eastern beaufort sea amundsen gulf research polar bear populations ecological interrelationships seals sea ice conditions began fall analysis movement data mark recapture studies tracking adult female bears satellite radio collars indicated two populations polar bears area one inhabits west coast banks island amundsen gulf second resident along mainland coast baillie islands canadato approximately icy cape alaska polar bears throughoutthe beaufort sea amundsen gulf severely overharvested establishment quotas canada cessation subsistence polar bear hunting alaska since populations recovered population estimates currently used management purposes northern southern beaufort populations respectively however population estimates dated redone female polar bears beaufort sea breed first time years age compared years age populations cubs normally remain mothers years prior weaning heavy ice conditions mid mid caused significant declines productivity ringed seals lasted years caused similar declines natality polar bears survival subadults reproductive success survival species increased changes sea ice environment consequent effects polar bears demonstrable parallel fluctuations mean ages polar bears killed year inuit hunters decadal scale pattern fluctuations ice conditions eastern beaufort sea changed response oceanographic climatic factors change resulted greater amounts open water recent years addition climatic warming major environmental factor greenhouse gas emissions continue increase unknown whether ecosystem return pattern decadal scale change exhibited previous decades polar bears seals respond ecological changes future research topics high priority
engineering degrees students must acquire basic knowledge beginning need given applied view subjects last years concretely case degree materials engineering students must deep concepts materials science engineering first years subjects however third fourth years ones must oriented advanced industrial knowledge students familiarize industrial engineering framework national european level related materials engineering taking account plurality multidisciplinary nature materials engineering degree related business sectors varied automotive aerospace civil engineering construction etc reason proposed two different activities learning based real practical cases internships companies
event natural man made disasters providing rapid situational awareness video image data collected salient incident scenes often critical first responders however computer vision techniques process media rich data intensive content obtained civilian smartphones surveillance cameras require large amounts computational resources ancillary data sources may available geographical location incident paper propose incident supporting visual cloud computing solution defining collection computation consumption architecture supporting fog computing network edge close collection consumption sites coupled cloud offloading core computation utilizing software defined networking sdn evaluate architecture algorithms using realistic virtual environment test beds also describe insights preparing cloud provisioning thin client desktop fogs handle elasticity user mobility demands theater scale application addition demonstrate use sdn demand compute offload congestion avoiding traffic steering enhance remote user quality experience regional scale application optimization fogs computing network edge core cloud computing managing visual analytics reduces latency congestion increases throughput
event contaminant introduced water distribution system utility managers must respond quickly protect public health mitigation strategies specify response actions warning consumers reduce water activities using news media flushing contaminated water hydrants performance alternative response actions may influenced sociotechnical dynamics consumer reactions contaminant exposure information event change water demands hydraulics propagation contaminant plume public health consequences research develops modeling framework test evaluate mitigation decisions utility manager may take protect public health wide range contamination events agent based modeling framework developed integrate social behaviors technical artifacts sociotechnical model evaluate public health consequences water event social actors including consumers utility managers represented agents coupled water distribution network model news media model evaluate performance response strategies strategies flushing hydrants encoded decision trees specify location timing hydrant flushing based activation water quality sensors agent based model described using overview design details protocol demonstrated virtual midsized municipality mesopolis results compare effectiveness flushing hydrants using cautious adaptive response strategies use news media disseminate warning messages framework applied cities evaluate alternative management strategies american society civil engineers
fast developing world today automatic generation control agc plays incredibly significant role offering inevident demand good quality power supply power system deliver quality power agc system requires efficient intelligent control algorithm hence paper novel fractional order fuzzy proportional integral derivative fofpid controller proposed agc electric power generating systems proposed controller tested first time three structures multi area multi source agc system gains fractional order parameters order integrator lambda differentiator gamma fofpid controller optimized using bacterial foraging optimization algorithm bfoa initially proposed controller implemented traditional two area multi source hydrothermal power system effectiveness established comparing results fopid fuzzy pid fpid pid controller based recently published optimization techniques like hybrid firefly algorithm pattern search hfa grey wolf optimization gwo algorithm approach extended restructured multi source hydrothermal thermal gas systems observed dynamic performance proposed bfoa optimized fofpid controller superior bfoa optimized fpid fopid pid differential evolution genetic algorithm optimized pid controllers also detected dynamic responses obtained different power transactions without appropriate generation rate constraint time delay governor dead zone effectively satisfy agc requirement deregulated environment moreover robustness suggested approach verified wide variations nominal initial loading system parameters distribution company participation matrix structure size position uncontracted power demand elsevier rights reserved
field hydraulic drive technology various power supply systems used within different power unit set ups two mostly used drive concepts modern electrohydraulic systems variable displacement pump driven constant speed electric motor fixed displacement pump driven variable speed electric motor disadvantages especially regarding increasing demand maximum efficiency entire power unit without lowering high dynamics combination variable pump speed controlled electric motor offers option setting two parameters drive rotational speed motor pump flow rate combination allows power unit components operate within areas maximum efficiencies called maximum efficiency drive prerequisite designing suitable controllers would ensure operations individual components within areas maximum efficiency regardless current operating point certainly knowledge efficiency area entire power unit paper presents procedure determining areas efficiency first basis simulation detailed models component later verification model using experiment
field manufacturing engineering process designers conduct numerical simulation experiments observe impact varying input parameters certain outputs production process disadvantage simulations time consuming results help fully understand underlying process instance common problem planning processes choice appropriate machine parameter set results desirable process outputs one way overcome problem use data mining techniques extract previously unknown valuable knowledge simulation results research examines use techniques within field virtual production intelligence vpi paper proposes novel approach applying machine learning models namely classification regression trees design laser cutting process evaluation shows models accurately identify regions multidimensional parameter space increase quality process high cut quality implemented models web based vpi platform user able gain valuable insights laser cutting process aim optimizing authors published elsevier
field natural products anthraquinones important category secondary metabolites present various vegetable species highly bioactive compounds potentially useful therapeutic applications antiviral anti bacterial anti cancer agents extraction processes using pressurized hot water offer environmentally friendly alternative traditional extraction purification methods applied anthraquinone containing plants knowledge high pressure phase equilibria anthraquinone solvent mixtures required evaluate potentiality processes need experimental data thermodynamic models able predict phase boundaries different process conditions work solubility dihydroxy anthraquinone quinizarin pressurized hot water measured using simple reliable dynamic method binary quinizarin measurements performed pressures bar group contribution association equation state gca eos definition cyclic ketone functional group cyc used calculate solid liquid equilibria binary mixtures anthraquinones pressurized hot water model able give good representation solubility behaviour quinizarin water published elsevier
field power electronics instrumentation scr power electronics device used analog gate trigger circuit scr often designed trigger scr nonlinear relationship conduction angle scr input signal analog gate trigger circuit nonlinear introduce errors control system nonlinear compensation difficult paper takes double base diode example designs analog circuit used trigger scr linear relationship conduction angle scr input signal analog circuit circuit practice reveal reliable practical method triggering scr
field wind energy electrical generator solutions converged small number technologies specific technical economic reasons paper investigates whether similar rationale exists within field oscillating water column wave energy converters predicted performance various generator options within typical wave regime validated means time domain matlab simulink model suitability otherwise brushed machines offshore marine environment examined detail generator configuration modelled annual energy output typical wave climate assessed consideration given impact speed control energy output
high speed sliding electrical contact large current temperature contact area rises quickly coupling action friction heating joule heating electric arc heating rising temperature seriously affects conductivity components yield strength materials well affects contact state lead damage shorten service life contact elements therefore vital significance measure temperature accurately investigate temperature effect damage rail surface aiming problem components damage high speed sliding electrical contact transient heat effect contact surface explored influence regularity sliding components damage obtained kind real time temperature measurement method rail surface high speed sliding electrical contact proposed condition current load based principle infrared radiation non contact temperature sensor used measure rail temperature dynamic distribution temperature field obtained simulation analysis connection temperature changes rail surface damage morphology damage volume analyzed established finally method reduce rail damage improve life components changing temperature field discussed
last decades rectangle earth pressure balance shield machine introduced primary tunneling tools soft soil excavation around world paper presents research performance rectangle shield machine analytical studies carried establish relation rectangle shield machine design key parameters segments support tail thickness soil layer harness strength stiffness buckling analysis shell structure results presented results show good stiffness displacement stability capacities achieved
last years ecosystem devices heterogeneous services emerged huge variety capacities characteristics new devices along applications services must used enhance quality life making users daily activities easier well increasing personal autonomy sense clear need creating interfaces adapt taking account characteristics user context application device one aspects consider adapting interfaces set preferences user using different applications devices user different preferences mainly related limitations developed system discovers users preferences related different devices applications system discovers set parameters well normal performance parameters
last years multitouch tangible user interfaces emerged powerful tool integrate interactive surfaces responsive spaces embody digital information besides providing natural interaction digital contents allow interaction multiple users time thus promoting collaborative activities information sharing particular characteristics opened new exploration possibilities edutainment context witnessed many applications successfully developed different areas children collaborative learning interactive storytelling cultural heritage medical therapy support however due availability different multitouch tangible interaction technologies different target computing platforms development deployment applications challenging end paper present gaine tangible augmented interaction edutainment software framework enables rapid prototyping development tangible augmented applications edutainment purposes gaine two main features first offers developers high level context specific constructs significantly reduces implementation burden second framework portable different operating systems offers independence underlying hardware tracking technology paper also discuss several case studies show effectiveness gaine simplifying development entertainment edutainment applications based multitouch tangible interaction elsevier rights reserved
last two decades adiponectin member adipokines family gained attention unique antidiabetic effects however presence brain adiponectin receptors adiponectin raised interest possible association neuropsychiatric diseases indeed clinical studies found altered concentration adiponectin plasma cerebrospinal fluid several pathologies including depression multiple sclerosis alzheimer disease stroke moreover recent preclinical studies also suggest involvement different physiological functions despite evidence studies attempted elucidate functional role adiponectin synapse address question investigated effect adiporon agonist adiponectin receptors synaptic transmission ltp schaffer collateral pathway surprisingly increasing concentration adiporon correlated lower ltp levels paired pulse ratio whereas basal transmission always preserved collectively data show adiponectin system beyond involvement metabolic diseases plays also critical role synaptic activity thereby representing putative target treatment synaptic pathologies
last two decades seen amazing development image processing techniques targeted medical applications propose multi gpu based parallel real time algorithms segmentation shape based object detection aiming accelerating two medical image processing methods automated blood detection wireless capsule endoscopy wce images automated bright lesion detection retinal fundus images former method identified segmentation object detection responsible consuming global processing time latter segmentation used shape based object detection compute intensive task identified experimental results show accelerated method running multi gpu systems blood detection wce images average times faster original cpu version able process frames per second applying multi gpu framework bright lesion detection fundus images able process frames per second speedup average times faster equivalent cpu version
literature number approaches proposed learning grapheme phoneme relationship inferring pronunciations letter present novel multistream framework conversion various machine learning techniques providing different estimates probability phonemes given graphemes effectively combined pronunciation inference precisely analogous multistream automatic speech recognition framework involves obtaining different streams estimates probability phonemes given graphemes combining based probability combination rules inferring pronunciations decoding probabilities resulting combination demonstrate potential proposed approach combining probabilities estimated state art conditional random field based conversion approach acoustic data driven conversion approach kullback leibler divergence based hidden markov model framework phonebook word task
mid women violence women wavaw first national feminist organization protest mediated sexual violence women pressured music industry cease using images violence women advertising article presents case study wavaw national boycott warner communications inc documents activists successful consumer campaign study reveals media violence central feminist organizing efforts wavaw related organizations helped establish climate concern violence motivated scientific research relationship exposure media violence subsequent aggression
paper concept cmos implementation four quadrant inverter based analog multipliers presented analog circuits utilizing cmos inverter become popular recently however research papers focus almost exclusively linear applications exceeding class analog operations multiplication analog signals basic nonlinear one may milestone step towards complete base analog signal processing blocks based cmos inverter
paper gleim opt express declared system quantum cryptography exploiting quantum key distribution qkd protocol additional reference state encoding sub carrier able distribute secret keys distance following shows simple attack realized beam splitter results loss privacy keys substantially smaller distances turns actual length secret key transmission qkd system encoding sub carrier frequency ten times less declared gleim opt express therefore impossible safely use keys distributed larger length communication channel shown maximum communication distance exceed even optimistic scenario
paper firstly insulation aging insulation cut crack fault models feeder cable established according characteristics electrical loads feeder cable rail voltage law different current law purposed orbital theory feasibility purposed law discussed engineering view results analysis show rail voltage law could carried real project lots interferences could separated different current law meets real projection request could carried lastly simulation tests done investigate effectiveness different current law detect cable faults laboratory results experiment show different current law great limitations detecting insulation cut crack fault feeder cable effectiveness impacted environment especially soil moisture another law found living detect insulation cut crack fault epr cable
paper seismic damage information six kinds buildings including brick concrete structure bottom frame brick concrete structure frame construction big span structure special structure farmhouse collected based architecture type damage degree height house seismic damage information statistic analysis damage characteristic structure basis damage characteristic dynamic response earthquake resistance mechanism studied correlation among site feature structure type strength materials construction technology seismic damage structure discussed
past body terminal considered exclusive source unwanted second order effects recently use body terminal becoming attractive opportunity improving performance analog integrated circuits low frequency harmonic distortion stems body effect dependent body effect coefficient analysis body effect present conventional flipped voltage follower fvf neglected however submicron low voltage circuits neglected paper propose utilize body effect positively using dynamic threshold mos dtmos transistor proposed fvf exhibits linear behaviour large excursions output voltage linear range increased improvement slew rate performance become symmetrical proposed fvf proposed fvf mapped tsmc cmos technology simulations low supply voltage validate proposed fvf proposed fvf expected useful low voltage high speed analog signal processing applications
past decade many numerical algorithms eikonal equation proposed recently research eikonal equation solver focused developing efficient parallel algorithms order leverage computing power parallel systems multi core cpus gpus graphics processing units paper introduce efficient parallel algorithm extends jeong fim fast iterative method originally developed gpu multi core shared memory systems first propose parallel implementation fim using lock free local queue approach provide depth analysis parallel performance method second propose new parallel algorithm group ordered fast iterative method fim exploits causality grid blocks reduce redundant computations main drawback original fim addition proposed fim method employs clustering blocks based updating order cluster updated parallel using multi core parallel architectures discuss performance fim compare state art parallel eikonal equation solvers
past decade increasing interest studying educational affordances multiplayer online role playing games mmorpgs using ksave knowledge skills attitudes values ethics century skills framework paper presents current state art mmorpgs empirical research considering latest overview reported review sought determine level maturity body mmorpgs research identify lacks knowledge respect types century skills current work considered research publications categorized empirical studies according research foci results one types century skills results revealed strong body evidence suggesting mmorpgs spaces variety century skills fostered yet mmorpgs research focuses investigation communication skill skills examined whilst creativity innovation well problem solving information literacy largely unexplored context discussion focuses understudied areas mmorpgs research aiming advance future inquiry addresses current challenges elsevier ltd rights reserved
past tenacious semiconductor problems operating temperature power consumption limited performance growth single core microprocessors microprocessor vendors hence adopt multicore chip organizations parallel processing new technology promises faster lower power needed short time trend floods first development cpu also peripherals like gpu modern gpus efficient manipulating computer graphics highly parallel structure makes even effective general purpose cpus range graphical complex algorithms however technology multicore processor brought revolution unavoidable collision programming personnel multicore processor high performance however parallel processing brings opportunity also challenge issue efficiency way programmer compiler parallelizes software explicitly keys enhance performance multicore chip paper propose parallel programming approach using hybrid cuda openmp mpi programming would two verificational experiments presented paper first would verify availability correctness auto parallel tools discuss performance issues cpu gpu embedded system second would verify hybrid programming could surely improve performance copyright john wiley sons ltd
polytocous european brown hare lepus europaeus successful implantations undergo embryonic resorption objective study establish minimally invasive ultrasound guided biopsy technique collect embryonic resorption tissue vivo sampled material genetically analysed determine paternity sex embryo female hares either mated artificially inseminated pregnancy confirmed ultrasound day six post ovulation subsequent embryonic development ultrasonographically monitored regular basis detect embryos undergoing resorption cell material resorption site collected ultrasonographic control via transabdominal biopsy placenta aspiration resorption fluid avoid breathing movements biopsy animals intubated short apnoea evoked assisted ventilation presence embryonic cells biopsy material confirmed microsatellite analysis fluid samples six placental samples lower success rate fluid samples attributed abundance maternal cells confirmed analysis fluid sample smears male sex embryos undergoing resorption detected sry analysis ten fluid samples one placental samples two biopsy techniques negative impact prenatal development healthy siblings influence future breeding performance females biopsied elsevier inc rights reserved
present article analyze polymorphous prejudice lesbians gays according sample portuguese heterosexual individuals tested differential importance demographic ideological psychological level variables predicting phenomenon results show male catholic right wing respondents fewer lesbian gay friends prove group exhibiting highest levels polymorphous prejudice furthermore introduction psychological level variables regression models increased explained variance polymorphous prejudice beyond remaining predictors additionally report different patterns results deploying regression analyses level sub scales polymorphous prejudice discuss results within light contemporary sexual prejudice frameworks reviewing utility results interventions targeting discriminated individuals
present paper use fuzzy linear regression analysis fuzzy similarity investigate relation various hardness scales tensile strength materials examine relation vickers brinell rockwell shore scleroscope hardness scales tensile strength common measurement range fuzzy regression models result show existence linear relation analysis resulting models fuzzy similarity results indicates strong similarities models different hardness scales results indicate similarity fuzzy regression reflects underling similarity physical quantities materials measured different hardness scales comparison conventional linear regression analysis shows ambiguities model better reflected case fuzzy regression models
present paper suitable model evaluate volume dependence thermal expansivity using reciprocal form volume dependence anderson griineisen parameter delta proposed newly developed relationship satisfied constraints infinite pressure behavior infinity results obtained present model show consistency experimental data nacl
present paper introduced general model equations formulation context lord shulman theory includes one thermal relaxation time green lindsay theory two thermal relaxation times well classical dynamical coupled theory study effect rotation magnetic field total deformation micropolar thermoelastic medium internal heat source moving constant speed analytical method used obtain formula physical quantities normal mode analysis comparisons made results three theories presence absence magnetic field well internal heat source comparison also made results three theories different values rotation elsevier ltd rights reserved
present study major aim evaluate date contamination status topolnitsa reservoir located region intensive copper mining constantly contaminated metals last decades thus measured concentrations surface water samples well liver ommon carp three different seasons spring summer autumn furthermore also studied carp response water quality observing hepatic morphological structure measuring biochemical parameters ldh alat asat activity general metal concentrations water varied present three seasons concentrations maximum permissible levels set law metal concentrations liver significantly higher water addition observed severe hepatic histological alterations included degenerative changes granular degeneration vacuolar degeneration hydropic degeneration fatty degeneration necrotic changes necrobiosis karyopyknosis karyorrexis karyolysis necrosis changes blood vessels hyperemia sinusoids major blood vessels found ldh activity inhibited common carp liver topolnitsa reservoir compared reference fish alat asat activity significantly increased compared reference based findings consider metal contaminated waters topolnitsa reservoir lead negative changes tissue cellular level fish organism include altered structure impaired functions liver
present study evaluate feasibility gene expression white blood cells peripheral marker winter depression sixteen patients winter type seasonal affective disorder included study blood taken venous puncture three time points winter prior following bright light therapy summer rna isolated converted crna amplified hybridized illumina gene expression arrays raw optical array data quantile normalized thereafter analyzed using metagene approach based previously published affymetrix gene array data raw data also subjected secondary analysis focusing circadian genes genes involved serotonergic neurotransmission differences conditions analyzed using analysis variance principal components metagene score matrix correction multiple testing statistically significant differences found another approach uses correlation metagene factor weights actual expression values averaged conditions comparing correlations winter summer bright light therapy summer significant changes several metagenes found subsequent gene ontology analyses david genetrail major metagenes suggest interaction brain white blood cells hypothesis driven analysis smaller group genes failed demonstrate significant effects results combined metagene gene ontology analyses support idea communication brain white blood cells future studies need much larger sample size obtain information level single genes elsevier inc rights reserved
present study address development application efficient tool conversion results obtained integrated computational fluid dynamics cfd computational reaction dynamics crd approach visualization google earth focus results typical environmental fluid mechanics studies city scale include characteristic wind flow patterns dispersion reactive scalars achieved developing code based java language converts typical four dimensional structure spatial temporal dependency data results keyhole markup language kml format visualization techniques often used revisited implemented conversion tool potential tool demonstrated case study smog formation due intense traffic emission rotterdam netherlands shown google earth provide computationally efficient user friendly means data representation feature useful visualization pollution street levels great importance city residents various meteorological traffic emissions easily visualized analyzed providing powerful user friendly tool traffic regulations urban climate adaptations
present work efficient surrogate based framework developed prediction motion induced surface pressure fluctuations integral force moment coefficients model construction realized performing forced motion computational fluid dynamics cfd simulations result processed via proper orthogonal decomposition pod obtain predominant flow modes subsequently nonlinear system identification carried respect applied excitation resulting pod coefficients input output model identification task recurrent local linear neuro fuzzy approach employed order capture linear nonlinear characteristics dynamic system reduced order model rom trained substitute flow solver within unsteady aerodynamic aeroelastic simulation frameworks given configuration fixed freestream conditions demonstration purposes rom approach applied lann wing high subsonic transonic flow due characteristic lambda shock system unsteady aerodynamic surface pressure distribution dominated nonlinear effects numerical investigations show good correlation results obtained rom methodology comparison full order cfd solution addition surrogate approach yields significant speed regarding unsteady aerodynamic calculations beneficial multidisciplinary computations elsevier ltd rights reserved
present work energy conservation properties smoothed particle hydrodynamics sph investigated presence fluid solid interactions similarly fluid phase solid bodies modeled solid particles whole solid fluid domain described unique particle system pressure velocity fields extended solid particles different ways taking account consistency issues related sph differential operators using projection navier stokes equations solid boundary shown solid particles considered energy equation particle system contains extra terms depend pressure velocity field extensions presence extra terms affect consistency sph model since tend vanish spatial resolution increased three prototypical numerical test cases considered order provide quantitative perspective matter confirm theoretical developments paper test cases show nature terms globally dissipative thus accordance second law thermodynamics particular viscous extra term displays remarkably slow rate convergence relevant outcome sph practitioners deal types flows elsevier rights reserved
process characterization modeling mechanical behavior geomaterials assumptions adopted related theory continuous medium homogeneity isotropy condition derived stress strain response thus development element tests undisturbed samples reconstituted laboratory actual evaluation discretization heterogeneity environment considered impact response shear strength fact extends numerical implementation different constitutive models application finite element methods discrete elements among methods reconstitution sand samples laboratory compaction pluviation moist tamping determine density levels achieved manufacture loose dense homogeneous samples samples used stregth tests triaxial resistance without taking account definition indicator establish real state heterogeneity progress prospecting techniques medicine ray computed tomography transcended fields quality assessment materials engineering proposal assessing condition heterogeneity sand samples considering main building techniques shown paper based development tomographic images subsequent treatment hounsfield information density readings initial application image segmentation techniques allows obtain baseline data points subsequent statistical analysis variability considering different volumetric groupings reconstitution evaluation measure reached soil samples could generalized analysis undisturbed samples allowing analysis relationship structure mechanical response characterization tests shear strength results study show high influence boundary conditions heterogeneous spatial distribution density reconstituted samples methods considered also allows think use methodology tool reviewing adjusting methods application study undisturbed samples heterogeneity study could incorporated constitutive modeling definition characteristic parameters model coherent analysis inherent induced fabric tensors
recent past renewable biobased natural polymers explored variety potential applications among various biorenewable polymers cellulose ingrained robust characteristics biodegradability nontoxicity durability availability thermal mechanical stability etc extensively studied properties improved different modification techniques among grafting considered influencive one comprehensive review article general chemistry cellulose different biological chemical physical physio chemical extraction techniques extraction lignocellulosic biomass purification bleaching techniques extracted cellulose methods cellulose grafting mechanism free radical grafting initiated variety chemical initiators reviewed recent developments field metal ion sorption applications grafted cellulosic copolymers related factors affecting metal ion sorption efficiencies cellulosic biosorbents extent grafting contact time temperature interference metal ions metal ion concentration biosorbent dose ionic strength solution etc also reviewed various adsorption isotherms models langmuir freundlich temkin dubinin raduskevich redlich peterson adsorption kinetic models pseudo first order pseudo second order intra particle diffusion models useful studying evaluating different sorption parameters mechanism rate sorption toxic hazardous heavy metal ions also summarized last part review adsorption thermodynamics desorption regeneration studies grafted cellulosic biosorbents also reviewed elsevier rights reserved
spawning environment salmonids quality intergravel flow essential abiotic requirement survival success incubated embryos one frequently investigated anthropogenic environmental impacts enhanced mobilization fine sediments entry riverine ecosystems considered major cause degradation variety biological processes habitats including spawning habitats salmonids catchments draining crystalline bedrock however like bohemian massif northern part austria excessive loading river channels coarse sand fine gravel sediments less cohesive fines common consequence altered catchment land use far less understanding exists mechanism possible implications coarse sand infiltration functioning intergravel flow salmonid redds investigate intergravel flow hydraulics response coarse sand infiltration brown trout spawning redds salmo trutta fario controlled conditions laboratory flume experiment three infiltration scenarios conducted infiltration segmental infiltration full section infiltration two times drop average intergravel flow velocity documented scenario cms scenario cms another clear reduction seen scenario cms scenario cms moreover scenario clear reduction intergravel flow distance traveled observed based findings conclude future considerations regarding sustainable catchment management salmonid fisheries include programs reduce excessive entry fines relevant catchments also entry excessive coarse sand riverine ecosystem copyright john wiley sons ltd
steel industry iron making system deals large quantities materials energy play critical role reducing emissions production costs specifically excess product gases used electricity generation otherwise lead pollution life cycle analysis performed compare environmental impact iron making system combined cycle power plant ccpp system producing amount electricity coal power plant results chinese steel plant show reduction energy conservation emission reduction potential ccpp system thus environmentally friendly mathematical programming formulation proposed optimal scheduling incorporates key technological constraints sensitive hourly changing electricity prices outcome increase revenue electricity sales compared schedule dynamically adjust price profile results also show emissions product gases avoided completely paper ends sensitivity analysis evaluate impact changes product demand gas storage ccpp capacity emission cost
study simple selective method based magnetic separation technology presented extraction sulfonamides sas environmental water followed liquid chromatography tandem mass spectrometry method magnetic surface molecularly imprinted polymers feo sio mips super paramagnetic property high selectivity toward sas developed magnetic adsorbents feo sio mips applied selective extraction sas environmental water extraction enrichment accomplished simultaneously single step simply stirring mixture adsorbents water samples feo sio mips characterized scanning electron microscopy fourier transform infrared spectrometry vibrating sample magnetometry adsorption thermodynamics kinetics employed study adsorption mechanism feo sio mips matrix effect method evaluated calibration curves obtained analyzing matrix matched standards show excellent linear relationship concentration range limits detection range relative standard deviations intra inter day obtained range respectively proposed method successfully applied determine sas six environmental water samples sas detectable four concentration
twenty first century people accepting rapid development information age emphasizing fast paced high efficiency also times higher education popularization application multimedia teaching educators students conflict traditional teaching learning methods special sector art design education use computers indispensable important one learn use tools attendant computer renderings said replaced traditional hand painted renderings status past design manuscript well position answer yes fifteen years ago purchased computer began study adobe photoshop teaching software corduroy autocad far always believed program design phase design manuscripts behavior human brain design thinking process computer graphics replaced
united states young black men sex men ybmsm bear single largest burden hiv aids epidemic whether hiv positive men population practice relatively safer sex hiv negative counterparts recently investigated purpose study compare selected sexual risk behaviors ybmsm hiv positive hiv negative counterparts geographic location southern convenience sample ybmsm completed computer assisted self interview private area clinic dedicated sexual health frequency prevalence sexual risk behaviors compared men hiv positive hiv negative time bivariate associations tested regression models adjusted age main male sex partner one quarter sample hiv positive study enrollment remarkably differences sexual risk behaviors observed hiv positive men less likely report recent sex woman likely report recent sex persons known hiv positive assessed outcome measures two significant findings represented significant differences adjusted analyses ybmsm residing southern may experience high levels hiv exposure risk risk exposing others hiv particularly urgent need exists improve post diagnostic hiv prevention efforts hiv positive ybmsm
article new easy implement dimensional chaotic system developed dynamic attitudes analyzed following analogue circuit implementation system done pspice simulation real circuit components finally micro controller based random number generator new chaotic system used also passed nist randomness tests designed furthermore user interface designed help matlab gui helps computer check designed random number generator presented elsevier gmbh rights reserved
article development swedish informatics curriculum studied described study design inspired curriculum theory presented lindensjo lundgren suggest using concept arenas arenas enactment transformation realisation discussing curriculum development data collection study comprises activities actors arenas enactment transformation collected data include contemporary articles journals reports booklets government documents archived documents findings show informatics education sweden evolved primarily focusing programming knowledge related automatic data processing offered exclusively vocational education later early introduced upper secondary school curriculum heading datakunskap enactment informatics curriculum encompassed programming system development computing relation applied sciences civics mathematics teachers much experimental work shown competencies upper secondary school teachers time rarely corresponded demands subject content knowledge resources pedagogical skills stereotypical examples therefore developed support teachers instructing subject content implemented theoretical natural science programme system development systemisation transformed twofold issue comprising vocational attributes societal aspects computer programming implementation today informatics education including programming curriculum draw lessons learned history successful outcome study emphasises necessity understand common incentives introducing computer programming curriculum requirement teachers pedagogical content knowledge stakeholders role curriculum development process
article novel expansion method successfully applied construct abundant travelling wave solutions kdv mkdv equation aid symbolic computation equation one popular equation soliton physics appear many practical scenarios like thermal pulse wave propagation bound particle etc method reliable useful gives general exact travelling wave solutions existing methods solutions obtained form hyperbolic trigonometric rational functions including solitary singular periodic solutions many potential applications physical science engineering many solutions new already constructed additionally constraint conditions existence solutions also listed
article propagation collision vector solitons investigated coupled variable coefficient nonlinear schrodinger equations describe amplification attenuation pico second pulses inhomogeneous multicomponent optical fibre different frequencies polarizations basis lax pair infinitely many conservation laws obtained integrability constraint among variable coefficients group velocity dispersion gvd nonlinearity fibre gain loss two mixed type bright dark bright dark vector one two soliton solutions derived via hirota method symbolic computation influence variable coefficients gvd nonlinearity vector soliton amplitudes velocities analysed asymptotic graphic analysis bound states elastic inelastic collisions vector two solitons investigated elastic also inelastic collision bright dark vector two solitons occur whereas collision bright dark vector two solitons always elastic bound states gvd nonlinearity affect types gvd nonlinearity constants collision period decreases gvd increases independent nonlinearity
article von karman problem infinite rotating disk extended case space rough disk equipped electrically conducting nanofluid buongiorno model employed incorporate brownian motion thermophoresis effects due nanoparticles mass transfer process accompanied zero normal flux condition additionally heat transfer mechanism inspected general temperature jump conditions accurate similarity solutions developed full range slip coefficients means standard shooting procedure also collocation based matlab routine used findings solutions impact parameters flow fields depicted plotting graphs predicted velocity distributions inversely proportional magnetic field parameter velocity slip effect also presents opposition momentum transport reduces hydrodynamic boundary layer thickness also found brownian motion negligible influence heat flux rotating disk thermal concentration boundary layer thicknesses increased due existence thermophoretic force axial velocity negative due downward fluid motion caused disk rotation analysis slip boundary also retrieved special case present model elsevier ltd rights reserved
article present literature reviews fire prevention methods especially mining industries using thermal image processing techniques fire protection systems crucial increased loss human lives due coal fires fatal explosions coal mines across world past decades growth demand energy mining coal expected year determining conditions leading breakout fire paramount detect uncertain fire breakout conditions thermal imaging considered significant among several early warning methods recognize spontaneous combustion coal piles temperature recordings sensors compaction testing ore seam gas tests evolution thermographic imaging applied various industrial sectors coal furnaces oil tankers building inspections security numerous applications mathematical models presented light safety dimensions mining industry missing links unattended areas mathematics application thermal image processing mining especially coal industry evolved gap knowledge suggested concluding statements
letter highly reconfigurable crossbar transmission line switch matrix magnetic resonance imaging mri system proposed unlike conventional crossbar switch configuration proposed structure manipulate matrix without doubling area occupancy also proposed structure includes signal loss compensation circuitry based inductor banks enhance signal noise ratio snr thus required numbers input output channels proposed structure reduce overall size number required component even increase quality images snr enhancement proposed structure implemented verified tesla mhz system comparison path loss snr phantom test image qualities
letter silicon carbide mosfet based integrated circuits designed fabricated successfully tested degrees degrees silicon carbide single mosfets remained fully operational degrees wide temperature range exhibited stable characteristics circuits include operational amplifier amp stage ring oscillator buffer tested shown functional degrees relatively small performance variation degrees degrees high temperature evaluation circuits confirmed stable operation survivability ring oscillator amp degrees
letter report first chip design active dispersive delay line ddl based upon distributed amplification structure distributed amplifier ddl exhibits nanosecond delay variation frequency band ghz chip temporal imager implemented active ddl linear chirp generator realized ramping control voltage voltage controlled oscillator experimental data exhibits pulse stretching well pulse compression system
note announce complete classification stability periodic roll wave solutions viscous shallow water equations onset froude number approximate infinite froude limit intermediate froude numbers obtain numerically particularly simple power law relation boundaries region stable periods appears potentially useful hydraulic engineering applications asymptotic regime onset provide analytic expression stability boundaries whereas limit infinity show roll waves always unstable academie des sciences published elsevier masson sas open access article license
note present novel approach using visual programming languages treating specific language impairments sli starting characteristics sli particular syntactic impairment need develop metalinguistic awareness assuming latest researches computer programming assessing language right show theoretical possibility treat linguistic impairments concerns linguistic social difficulties use visual programming particular scratch study application field yet believe importance sharing ideas
panel contributors recent book ethics pervasive information communication technologies pict make short presentations areas expertise half panel time reserved open discussion pervasive ict similar ubiquitous computing ubicomp pervasive computing everyware ambient intelligence ami includes many different concrete artifacts including tabs pads boards dust skin clay course smartphones three characteristics distinguish pict could anywhere everywhere buildings billboards floors restrooms purses pockets coffee makers pacemakers eyeglasses kitchen sink detects collects organizes acts upon transmits information often wirelessly internet presence operation often undetected casual users whether hidden physically computer chips embedded automobiles functionally functional invisibility occurs function use technology announced tracking online behavior announced cryptic fashion terms use becomes ambient process familiarization smartphones become ordinary wallets facebook becomes way life ethical challenges posed pict new emerging technologies book panel exercises anticipatory ethics ethical analysis aimed influencing development new technologies panel organized follows introduction panel pimple gaps lags ethics regulation ehealth seelman vulnerable marginalized populations pict jones sum greater parts emergent failure modes interconnected automated systems searing values levers practices encourage ethics design shilton pict responsibility theory practice miller principled pervasive ict pimple open discussion
paper continuous time state space aerodynamic model developed based boundary element method boundary integral equations governing unsteady potential flow around lifting bodies presented modified thin wing configurations next bem discretized problem unsteady flow around flat wing equivalent original geometry recast standard form continuous time state space model considering auxiliary assumptions system inputs time derivative instantaneous effective angle attack thickness camber correction terms outputs unsteady aerodynamic coefficients validate model predictions aerodynamic coefficients variations due various unsteady motions different wing geometries compared results direct bem computations verified numerical theoretical solutions comparison indicates good agreement since resulting aerodynamic model continuous time domain particularly useful optimization nonlinear analysis purposes moreover state space representation appropriate form aerodynamic model design control applications elsevier ltd rights reserved
paper general model steady state simulation solar absorption chiller proposed novelty model calculate physical state streams rather fix especially outlet condenser evaporator thermodynamic properties mixture calculated suitable predictive thermodynamic models hence working pair changed easily using thermodynamic model general positive flash model able describe possible states sub cooled super heated biphasic various streams considered multicomponent mixtures positive flash set governing equations valid phase regions another originality present study generator modelled distillation column using theoretical plate concept mesh equations mass balance equilibrium summation heat balance written stage despite modular structure software global solution strategy implemented using newton raphson method model successfully compared example literature deals gax generator absorber heat exchange configuration absorption chiller using ammonia water working pair elsevier ltd rights reserved
paper new output measurement based method proposed allows identifying modal parameters structures subjected natural loads wind ocean waves traffic human walk contrast existing output identification techniques model unmeasured load white noise process statistical information dynamic excitation obtained measurements wind fluctuations vicinity structure taken account improve identification results well allow identifying unmeasured load process exciting structure identification problem solved basis recently developed method called fractional spectral moment fsm decomposition transfer function allows representing gaussian random processes known power spectral density psd function output linear fractional differential equation white noise input present work efficiency accuracy method improved use alternative fractional operator based fsm decomposition state space representation arbitrarily correlated gaussian processes proposed neither requires factorization psd function optimization procedure combined state space model structure leads overall model white noise input efficiently combined state space model based parameter identification algorithms weighted extended kalman filter algorithm used method applied identification stiffness damping parameters three story shear building subjected wind turbulences von karman velocity pdf function
paper novel low voltage ultra low power differential voltage current conveyor dvcc based folded cascode operational transconductance amplifier ota one differential pairs floating gate mos transistor presented main features proposed conveyor design simplicity rail rail input voltage swing capability low supply voltage ultra low power consumption mere thanks features proposed circuit could successfully employed wide range low voltage ultra low power analog signal processing applications implementation new multifunction frequency filter based proposed dvcc presented paper take advantages properties proposed circuit pspice simulation results using cmos technology included well validate functionality proposed circuit elsevier ltd rights reserved
paper certain properties algorithms used symbolic manipulation signal flow graphs investigated rule based approach mason formula compared respect preservation minimal rational representation shown counter example rule based method possess property factor cancellations allowed elementary operation level new efficient algorithm proposed problem resolved
paper criticize theory biased overly individualist approaches understanding others introduce pair account joint attention pragmatic affectively charged intentional relation argue relation obtains virtue intentional contents minds attenders received understanding intentional states propositional attitudes recognize call subject mode position mode intentional content based findings developmental psychology propose subject mode content represents attenders subjects like least disposed act jointly conclude arguing joint attention experience understand affective actional perceptual relations non conceptual level prior differentiation mind body
paper inlcjet shaped barium titanate thin films examined sem afm optical microscopy along xrd raman spectroscopy order study effects drying chemical additives ink concentration printing parameters microstructure phase composition inkjet printing attractive way shaping functional materials simple setup low cost digital control possibility obtaining complex forms without post processing make technique highly competitive application microelectronics common way preparing inks via powder dispersion involves high temperature treatment degrees order achieve dense uniform structure thus utilized energy efficient sol gel approach final phase composition achieved situ substrate elsevier ltd techna group rights reserved
paper shown svd matrix constructed efficiently hierarchical approach proposed algorithm proven recover singular values left singular vectors input matrix rank known hierarchical algorithm used recover largest singular values left singular vectors bounded error also shown proposed method stable respect round errors corruption original matrix entries numerical experiments validate proposed algorithms parallel cost analysis
paper proposed pid controller tuning method new equation state adding new integral element output variable pid controller design method using lqr method order make sure robust stable control performance inverted pendulum system suitable evaluating effectiveness control theory due unstable strong nonlinearity research could confirm excellent stability excellent control performance inverted pendulum system simulation inverted pendulum
paper possibilities analog signal processing afford towards realising lower power consumption low latency solutions emerging antenna array wireless systems discussed shown analog processor realised construct radios used propagation difficult enhanced trust systems approach permits operation real time analog processing unduly throttled power consumption data throughput limits associated current digital signal processing hardware
paper analysis dynamic behavior variable speed wind turbine vswt presented comparison variable speed constant speed mode operation also performed examined wind turbine equipped dual pwm voltage source converter cascade connected electrical network represented thevenin equivalent conventional scaler control applied electrical generator employing constant principle furthermore grid side inverter assumed capable regulating output reactive power order maintain voltage within permissible variations objective point advantages variable speed operation improved output power quality decrease mechanical stresses capability controlling voltage local grid
paper effect reclaimed asphalt pavement rap low temperature properties asphalt mixture experimentally investigated modelled two test methods used bending beam rheometer bbr mixture creep test based static loading dynamic shear rheometer dsr mixture complex modulus test uses oscillatory loading first creep stiffness value thermal stress critical cracking temperature complex modulus derived statistically graphically compared rheological huet model used evaluate experimental bbr measurements derive simple relationship associating characteristic time mixtures rap content statistical results indicate mixtures prepared rap relatively poorer performance compared virgin mixtures rap content based rheological modelling appears rap characteristic time linked exponential relationship
paper optimization procedure salient pole synchronous motor spsm low rotational speed lrs marine electric propulsion systems meps presented involving preliminary critical design stages objective function introduced motor critical design includes construction operating maintenance costs motor proposed methodology includes sensitivity analysis pareto front investigation techniques
paper role control history control engineering education discussed possible web based approach historical aspects control education presented paper approaches fundamentals creating traditional webquests well author approach creation learning tools suggested approach reject use internet resources use local ones simplify system performance evaluation add self assessment tests variant final test ifac international federation automatic control hosting elsevier ltd rights reserved
paper various architectures electromagnetic harvesting devices realized department information engineering university brescia reported estimating usability biomedical applications furthermore paper shows first attempt new electromagnetic generator architecture proposed system modelled simulated showing promising results
paper proposed algorithm based hierarchical reinforcement learning hrl parallel computing solve online computing problem server problem ksp size storage structure used reinforcement learning obtain optimal policy grows exponentially number states actions limiting use smaller problems due curse dimensionality problem modeled multiple steps decision process computed parallel applying learning algorithm obtain optimal policies reduced number nodes obtained clustering process results show applicability proposed method real problems large size
paper address identification linear time invariant single input multi output simo systems particular assess performance prediction error method quantifying variance parameter estimates using orthonormal representation modules composing simo structure show parameter estimate module depends model structure modules correlation structure output disturbances provide novel results quantify variance error parameter estimates finite model orders effects noise correlation structure model structure input spectrum visible particular show sensor increase accuracy module common dynamics estimated module identified using less parameters modules derive noise correlation structure gives minimum total variance implications results illustrated numerical examples simulations elsevier ltd rights reserved
paper consider mutual exclusion problem multiple access channel mutual exclusion one fundamental problems distributed computing classic version problem processes execute concurrent program occasionally triggers use shared resources memory communication channel device etc goal design distributed algorithm control entries exits shared resource also called critical section way time one process accessing considerations shared resource shared communication channel multiple access channel main challenge arises channel also mean communication processes consider classic slightly weaker version mutual exclusion called mutual exclusion period process staying critical section probability process critical section show channel settings classic mutual exclusion feasible even randomized algorithms mutual exclusion relaxed channel settings prove exponential gap makespan complexity classic mutual exclusion problem weaker exclusion version also show guarantee fairness mutual exclusion algorithms process wants enter critical section eventually succeed
paper consider problem synthesis equivalent circuits containing nonlinear electrical circuits general number non linear elements system differential equations describing linear non autonomous multi pole quasiequivalence transformations allows synthesize equivalent circuit multi pole consisting two pole linear nonlinear resistors controlled voltage sources etc question replacing series connected voltage sources controlled operational amplifier implementation linear nonlinear two pole resistors
paper deal rlc rlcg circuits coefficients influenced colored noise approach mathematical description situation via stochastic differential equations present numerical solutions corresponding equations compare deterministic solution stochastic ones also compute illustrate corresponding confidence intervals stochastic solutions numerical simulations examples carried using matlab
paper extend figures merit class symmetrical otas fully differential case compare topologies literature analysis shows power consumption cmfb significant role determining efficiency ota hand cmfb needed set desired output common mode voltage improve cmrr propose complementary triode cmfb triode cmfb applied nmos pmos current mirrors suitable class symmetrical otas show case studies deep submicron cmos technology assess effectiveness proposed solution copyright john wiley sons ltd
paper introduce quasi electrical model high efficiency interdigitated back contact ibc solar cell distributed electrical network based two diodes circuit elementary units allows accounting resistive losses due transport emitter back surface field bsf fingers busbars metallization moreover model electrical shading losses attributed bsf busbar calibrated electrical components model according experimental measurements real devices validity model demonstrated good agreement simulation experimental results dark illuminated measurements without masked busbars model easily applied simulate optimize different metal grid layouts authors published elsevier ltd
paper introduce blockimpress visual graphical block programming language making web presentations computer programming show practical examples use
paper investigate theoretically least cost size problem least cost deviation problem nonlinear size structured vermin population model separable mortality takes fertility rate control variable obtain existence unique non negative solution considering separable solution model crucial obtain optimal control strategy also illustrate continuous dependence population density initial value control parameter finally study least cost size problem least cost deviation problem conclusion would useful managing vermin elsevier inc rights reserved
paper present complex valued recurrent neural network cvrnn trained recursive levenberg marquardt learning algorithm complex domain applying problem dynamic system identification adaptive neural control scheme nonlinear oscillatory plant methodology applied two different cvrnn topologies different kinds activation functions furthermore applied cvrnn identification control particular case nonlinear oscillatory mechanical plant validate performance adaptive neural controller using algorithm developed throughout work compared complex valued backpropagation learning algorithm obtained comparative simulation results using flexible robot arm gives good performance derived control schemes results show priority recursive learning learning use constructed activation functions neural network topology
paper present quad band single chip gsm gprs radio digital cmos process based digital processor drp technology chip integrates functions physical layer protocol stack peripheral support single chip soc transmitter uses low area small signal digital polar architecture merging amplitude phase information directly dac receiver based direct sampling discrete time analog signal processing dedicated internal microprocessor manages digital controls provide best achievable performances transceiver exceeds gpp specifications demonstrating receive margin spectral mask khz offset gsm bands transceiver best class area occupies silicon area
paper present analysis stability two degree freedom system modeling robotic arm connected actuator elastic joint subject digital position control system consists two lumped masses connected spring damper model one actuator system underactuated certain sense two cases considered referring collocated noncollocated configuration stability analysis presented using continuous discrete time approach discrete time approach related case digital controller typical real applications samples position velocity signals discrete time intervals therefore generates piecewise constant control force introducing delay control system well stability charts presented parameter space sampling time control gains differences highlight role played resonances finite sampling frequency natural frequency system achieving robust stability respect parameter variations
paper present fpga implementation discrete wavelet transform dwt used image compression lifting based wavelet transform modeled simulated using matlab dsp implementation methodologies used optimize required hardware signal flow graph dependence graph derived optimized implement hardware description circuit verilog circuit code synthesized realized using field programmable gate array fpga flexke family post synthesis simulations confirm circuit operation efficiency
paper present two sets parallel algorithms identifying real time small signal dynamic models power systems using multiple sources synchrophasor data first problem posed terms identifying transfer matrix single input multiple output simo power system models using linear least squares lls parallelism implemented parallel execution matrix multiplications using multiple processors workers given constraints sequential communication limited local memory may arise due multiple applications running workers time novel scheduling algorithm proposed enable flexible deadlines meet constraints scheduling algorithm minimizes total time execution constraints solved via integer programming second problem posed similar parallel algorithm identifying linearized state variable model power system using linear nonlinear least squares nls presence scheduling performance algorithms studied via simulations ieee bus machine power system model compared centralized non parallel implementation
paper propose logic based framework inspired artificial intelligence scaled practical database programming applications computation framework viewed task generating sequence state transitions purpose making agent goals true states represented sets atomic sentences facts representing values program variables tuples coordination language facts relational databases herbrand models model theoretic semantics entire sequence states events combined single model theoretic structure associating timestamps facts events operational semantics facts updated destructively without timestamps show model generated destructive updates identical model generated reasoning facts containing timestamps also extend model intentional predicates composite event predicates defined logic programs containing conditions first order logic query current state
paper proposed multi stage algorithm small wind turbine power plant control supports maximum extracted power independently traditional tip speed ratio using wind speed made measurements wind turbine parameters urban prairie territories showed necessity power controlling turbine vindicated efficiency control small wind turbines urban regions also formulated conditions structure microprocessor operation described algorithm wind turbine power control showing possible situations states state described corresponding microcontroller response activity showed advantages pulse width modulation pwm converting electric values
paper report approach establish safety properties cooperating systems polynomial time state space exponentially large number cooperating subsystems consists constructing family called inducers system reduction operator call edge match furthermore draw connection approach theory relational databases aside pointing interesting connection fields use connection apply results theory relational databases approach elsevier rights reserved
paper study generalized coupled variable coefficient modified korteweg vries cvcmkdv system models two layer fluid applied investigate atmospheric oceanic phenomena atmospheric blockings interactions atmosphere ocean oceanic circulations hurricanes conservation laws cvcmkdv system derived using multiplier approach new conservation theorem addition similarity reduction exact solutions aid symbolic computation computed
paper printing novel printing process considered deposition polymers synthetic fabrics introduce flexible resource efficient cost effective textile functionalization processes conventional printing process like screen inkjet printing aim develop integrated tailored production process smart functional textiles avoid unnecessary use water energy chemicals minimize waste improve ecological footprint productivity adhesion polymer nanocomposite layers printed directly onto textile fabrics using fused deposition modeling fdm technique investigated different variables may affect adhesion properties including printing process parameters fabric type filler type incorporated polymer considered rectangular shape according peeling standard designed computer aided design cad find effect different variables polymers printed different series experimental design nylon polyamide fabrics polylactic acid pla fabric pla pla fabric finally nanosize carbon black pla pla multi wall carbon nanotubes pla cnt pla nanocomposites pla fabrics adhesion forces quantified using innovative sample preparing method combining peeling standard method results showed different variables printing process like extruder temperature platform temperature printing speed significant effect adhesion force polymers fabrics direct printing model proposed specifically deposition commercial printer nylon filament fabrics following among printed polymers pla composites high adhesion force pla fabrics authors published elsevier open access article license http creativecommons org licenses
paper dimensional nonlinear schrodinger equation dimensional heisenberg ferromagnetic spin chain bilinear anisotropic interactions investigated via hirota method symbolic computation bilinear forms multi soliton solutions derived one two three solitons analyzed graphically find amplitudes widths two three solitons keep invariant interaction bell shape one soliton well parallel crossed two three solitons respectively observed asymptotic analysis expressions denote two solitons interactions obtained interactions two solitons proved elastic elsevier ltd rights reserved
paper decoupled proportional integral derivative pid control approach seismic control smart structures presented first state space equation structure transformed modal coordinates parameters modal pid control separately designed reduced modal space feedback gain matrix controller obtained based contribution modal responses structural responses performance controller investigated adjust control force piezoelectric friction dampers pfds benchmark base isolated building order tune modal feedback gain controller suitable trade among conflicting objectives reduction maximum modal base displacement maximum modal floor acceleration smart base isolated structure well maximum modal control force created using multi objective cuckoo search mocs algorithm terms reduction maximum base displacement story acceleration numerical simulations show proposed method performs better reported controllers literature moreover simulation results show pfds able efficiently dissipate input excitation energy reduce damage energy structure overall proposed control strategy provides simple strategy tune control forces reduces number sensors control system number controlled stories
paper disturbance observer dob algorithm proposed solve output voltage regulation interleaved boost converter ibc presence unknown disturbance parameter uncertainty ibcs improved model boost converters provide better operation conventional converters also converters rather complicated therefore modeling cumbersome solve problem signal flow graph sfg method implemented cells ibc main advantage sfg obtaining unified dynamic mode converter beside modeling problem unknown disturbances input voltage ripple mismatching duty cycles load variations inevitable real circuit degrade system performance obtain high performance regulation presence disturbances dob integrated optimal controller according models duty cycle variation limited optimal control technique implemented achieve good tracking furthermore dob estimate compensate unknown disturbances simulation results real model cells ibc indicates application dob sfg modeling quite effective correct performance ibc presence unknown disturbances
paper front end electronics based application specific integrated circuit asic presented future imaging atmospheric cherenkov telescopes iacts achieve purpose channel asic chip parisroc photomultiplier array integrated sige reaclout chip used analog signal processing digitization digitized results sent server user defined user datagram protocol internet protocol udp hardcore engine ethernet managed fpga prototype electronics fulfilling requirements wide field view cherenkov telescope array wfcta large high altitude air shower observatory lhaaso project designed fabricated tested prove concept design detailed description development results test measurements presented using new input structure new configuration asic dynamic range circuit extended highly precise time calibrating algorithm also proposed verified optimized mass production test results suggest proposed electronics design fulfills general specification future iacts elsevier rights reserved
paper generalized kdv caudrey dodd gibbon kdv cdg equation investigated describes certain situations fluid mechanics ocean dynamics plasma physics using bell polynomials lucid systematic approach proposed systematically study hirota bilinear form soliton solution respectively furthermore based riemann theta function onequasi two quasi periodic wave solutions also constructed finally asymptotic relation quasi periodic wave solutions strictly analyzed reveal relations quasi periodic wave solutions soliton solutions
paper method proposed identification siso nonlinear models two ill known components different nature linear possibly dynamic part static nonlinear one method well adapted priori information available nonlinear component identified based difference operator enables cancel nonlinear term applied model ill known linear part remains transformed model therefore identified independently nonlinear term based identified linear component access pseudograph nonlinear term whose shape give precious information parameterization unknown nonlinear part identification identification model consideration defined abstract framework weak hypotheses proposed approach large scope highlight method class dynamic volterra models including hybrid models dynamic inclusions considered application copyright john wiley sons ltd
paper method proposed realize grid multi scroll chaotic system current feedback operational amplifier cfoa firstly nonlinear circuit designed based cfoa grid multi scroll chaotic circuit designed relevant circuit parameters calculated finally circuit simulation conducted results show circuit higher central frequency needs less components possesses simpler circuit structure good frequency characteristic port characteristic cfoa
paper multistage susceptible infectious recovered model distributed delays nonlinear incidence rate investigated extends model considered guo guo shuai global dynamics general class multistage models infectious diseases siam appl math appropriate realistic conditions global dynamics completely determined basic reproduction number infection free equilibrium globally asymptotically stable disease dies stages unique endemic equilibrium exists globally asymptotically stable hence disease persists stages results proved utilizing theory non negative matrices lyapunov functionals graph theoretical approach copyright john wiley sons ltd
paper new cmos minus type current controlled third generation voltage conveyor vciii presented application example using presented new active building block novel voltage mode first order pass filter proposed instead floating resistor electronically controllable intrinsic resistance terminal used hence circuit resistorless shows low sensitivity performance behavior pass filter verified spice simulations tsmc level cmos process parameters used confirm theoretical analysis
paper new frequency agile filter structure analog signal processing proposed using mos technique contrast conventional analog building blocks filter designed mos transistors parasitic capacitances mos transistor used instead classical capacitors operating frequency range improved power consumption decreased simulations performed cadence environment using tsmc parameters
paper new identification method large heterogeneous spatially interconnected systems presented string different systems state space representation considered proposed algorithm optimizes output error global system using steepest descent gauss newton methods main contribution work jacobian hessian matrix entirely captured using sequentially semi separable sss matrices therefore computations optimization routine performed complexity linear number subsystems fact permits obtain models large interconnected systems low computational cost finally numerical example presented order show effectiveness proposed algorithm
paper new low power low noise operational amplifier dedicated implantable biomedical applications introduced amplifier designed minimize input referred noise power consnmption rednce inpnt thermal noise use ekv model set bias currents transistors rednce flicker noise pmos inpnt transistors large gate areas operating weak inversion used noise rednction techniqne switched biasing applied involves switching transistor periodically accnmnlation cntoff inversion region helps fnrther reduce flicker noise transistors use switched biasing allows rednce inpnt noise withont increase current thus allows avoid problem trading power noise using techniqne able achieve extremely low input noise rms desired bandwidth small snpply cnrrent additional circuitry required switched biasing consumes minimal power average power consnmption amplifier makes ideal implantable applications gain amplifier required frequency range phase margin degrees cmrr greater frequencies circuit designed using tsmc process analog design environment cadence virtuoso performance circuit studied process corners namely simulations carried degrees normal human body temperature
paper new circuit realization voltage mode first order pass filter apf presented proposed apf scheme composed single grounded capacitor three resistors one negative main advantage circuit common ground terminal input output proper functionality passive element matching required negative resistance implemented arbel goldminz operational transconductance amplifier theoretical results verified spice simulations using ptm level cmos process bsimv parameters
paper novel analysis method iterative learning control ilc algorithms presented even though expressed lifted system representation hence time domain convergence rate function frequency content error signal determined subsequently based analysis method novel ilc algorithm ilc proposed convergence rate specific frequencies set directly design process allows simple tuning priori known convergence rates using ilc design shown predict required number iterations convergence achieved depending reference trajectory information system repeatability numerical examples given experimental results obtained internal combustion engine test bench shown validation published elsevier ltd
paper novel high speed elliptic curve cryptography ecc processor implementation point multiplication field programmable gate array fpga proposed new segmented pipelined full precision multiplier used reduce latency lopez dahab montgomery algorithm modified careful scheduling avoid data dependency resulting drastic reduction number clock cycles ccs required proposed ecc architecture implemented xilinx fpgas virtex virtex virtex families best knowledge single three multiplier based designs show fastest performance date compared reported works individually one multiplier based ecc processor also achieves highest reported speed together best reported area time performance virtex mhz virtex mhz advanced virtex mhz finally proposed three multiplier based ecc implementation first work reporting lowest number ccs fastest ecc processor design fpga ccs get virtex
paper novel metamaterial absorber proposed absorber based metamaterial kind artificial periodic structures top layer absorber composed split ring resonators srrs square metal patches smps srr bottom layer covered whole metal special structure top layer makes unit cell resonate adjacent frequencies different modes makes absorber work broadband moreover oblique symmetrical unit cell makes absorber suitable wave namely polarization insensitive simulation calculation results show absorber able absorb power ghz relative bandwidth wave proposed absorber also fabricated measured experimental results agree simulation ones well broadband polarization insensitivity properties proposed absorber make promising application prospect shielding stealth technology
paper novel tilt integral derivative controller filter tidf proposed load frequency control lfc multi area power systems initially two area power system considered parameters tidf controller optimized using differential evolution algorithm employing integral time multiplied absolute error itae criterion superiority proposed approach demonstrated comparing results recently published heuristic approaches firefly algorithm genetic algorithm particle swarm optimization pso optimized pid controllers interconnected power system investigations reveal proposed tidf controllers provide better dynamic response compared pid controller terms minimum undershoots settling times frequency well tie line power deviations following disturbance proposed approach also extended two widely used three area test systems considering nonlinearities generation rate constraint grc governor dead band gdb improve performance system thyristor controlled series compensator tcsc also considered performance tidf controller presence tcsc investigated observed system performance improves inclusion tcsc finally sensitivity analysis carried test robustness proposed controller varying system parameters operating condition load pattern observed proposed controllers robust perform satisfactorily variations operating condition system parameters load pattern isa published elsevier ltd rights reserved
paper parallel high order envelope following method presented proposed method exploits high order stable obreshkov formula obf provide superior accuracy speedup technique utilizing obf provides accurate faster analysis keeping accuracy conventional low order integration methods addition parallel method based multiple shooting techniques used using allows partitioning solving sensitivity equations parallel also shown proper partitioning scheme high cpu scalability achieved
paper practical pole placement technique proposed shape dynamic response large scale structure end similarity transformation diagonalizes mass stiffness matrices large scale structure applied system coupled second order ordinary differential equations ode system equations represents large scale structure transformed principal coordinates new coordinate system special state feedback controller called inner loop used decouple system equations reduce uncoupled second order ode since system represented uncoupled second order ode poles second order ode assigned one time using separate proportional derivative controller set controllers form outer loop paper full state feedback controller simply aggregation inner outer state feedback loops sought assign poles large scale structure analytical proof proposed state feedback controller places poles large scale structure provided final part paper poles large scale truss structure assigned using pole placement technique proposed research
paper reduced order modeling approach based computational fluid dynamics presented elastic wing control surfaces transonic regime treat computational fluid dynamics grid around geometrical discontinuities due deflection control surfaces constant volume tetrahedron method transpiration method combined together without deforming grid based input output data computational fluid dynamics solver one multiple input multiple output discrete time state space model wing identified via robust subspace algorithm control surface one one input multiple output discrete time state space model identified using algorithm precomputed state space models flight parameters generalized aerodynamic forces range flight parameters computed interpolating output data methodology applied elastic wing model two control surfaces generalized aerodynamic forces compared results computational fluid dynamics solver validate reduced order modeling approach transonic regime american society civil engineers
paper simple implementation elliptic curve equation field programmable gate array fpga proposed elliptic curve cryptography ecc offers smaller key size without sacrificing security level brief survey applying main equation elliptic curve different values coefficients comparison results depended correlation coefficient value value implemented fpga according correlation results plaintext image ciphertext image matlab equation applied ultra wide band uwb system secure transmission data wireless channel brief survey uwb technology implemented software simulation secured system based ecc algorithm
paper single current sensor technique scst proposed single phase full bridge inverters proposed scst measures currents multiple branches time reconstructs average inductor capacitor load current single switching cycle since branches current filter load obtained using scst inductor capacitor current feedback schemes selectively applied taking advantages paper also analyzes current feedback schemes view point closed loop output impedance proposed scst analysis paper verified experiments kva single phase uninterruptible power supply ups
paper subcritical supercritical organic rankine cycle orc designed recover exhaust gas waste heat biogas fuelled combined heat power chp engine chp engine located belgium uses biogas fuel produced digestion domestic wastes anaerobic digestion rfa selected working fluid first system parameters net power mass flow rate pumps total power consumption total evaporator exergy inlet thermal efficiency exergy efficiency improved changing turbine inlet temperature pressure second low analysis overall system system components determined best performed subcritical supercritical cycles compared subcritical orc supercritical orc shown better performance best performed cycle net power thermal efficiency exergy efficiency evaluated subcritical orc supercritical orc respectively elsevier ltd rights reserved
paper three stage class operational transconductance amplifier ota large slew rate presented reversed nested miller compensation technique used stabilize proposed ota allowing slew rate enhancement achieved using class input output stages flipped voltage follower cell first stage combination switched capacitor level shifter last stage utilized implement class operation circuit level simulation results provided using hspice cmos technology show enhancement large signal fom approximately power dissipation compared class ota achieved settling time accuracy proposed class conventional class otas respectively
paper unified averaged modeling method proposed investigate fast scale period doubling bifurcation full bridge integrated buck boost inverter peak current control order increase resolution conventional classic averaged model half switching frequency sample hold effect inductor current absorbed averaged model proposed unified averaged model capture high frequency dynamical characteristics buck boost inverter extension modification conventional averaged model based unified mode fast scale bifurcation identified corresponding bifurcation point predicted help locus movement poles underlying mechanisms revealed detailed analysis shows occurrence high frequency oscillation means fast scale bifurcation occurrence low frequency oscillation leads slow scale bifurcation finally demonstrated unified averaged model provide general method investigate slow fast scale bifurcations unified framework also quite straightforward design oriented method directly applicable
paper visible light communication based three dimensional indoor positioning system employing dedicated algorithm using code division multiple access technique proposed solve mutual interference among reference source points light signal emitted cdma modulated white led carrying led position information received positioning terminal intensity modulation direct detection position terminal estimated based rss three dimensional localization algorithm using orthogonality spreading codes separation overlap among visible identification code time domain frequency domain realized according identification information position located associated area precise location calculated novel three dimensional positioning algorithm based signal attenuation simulation results show proposed location algorithm high accuracy average positioning error snr real time small positioning system also demonstrate test performance system good positioning accuracy proposed positioning algorithm simple require synchronization processing features outperform existing indoor wireless localisation approaches
paper ambient intelligence ami architecture devising implementing smart laboratory university presented architecture relies novel meta model abstracts laboratory ambient using context model adaptation model end user model domain model thus architecture offers end users set adaptive ami services supplied smart agents wireless sensor networks architecture coded using sqlite jade protege clips simulated oracle solarium environment latency scalability proposed architecture well ability supply effectively ami services tested using qualitative quantitative standard performance metrics
paper image interpolation method based even odd decomposition eod proposed input signal interpolation decomposed even odd vectors eod different interpolation methods applied even odd vectors respectively paper presents analysis two vectors new design methods also based new design method signal flow graph proposed method provided compared cci method terms complexin evaluate proposed method conduct experiments complexity comparison results indicate proposed interpolation method outperform existing method terms objective subjective image quality also requires less complexity
paper improved auto scaling variable step size maximum power point tracking mppt method photovoltaic system proposed achieve simultaneously fast dynamic response stable steady state power first improvement made step size scaling function duty cycle controls converter algorithm secondly proposed address wrong decision may made abrupt change irradiation proposed auto scaling variable step size approach compared various approaches literature classical fixed step size variable step size recent auto scaling variable step size maximum power point tracking approaches simulation results obtained matlab simulink given discussed validation elsevier rights reserved
paper darboux transformation symbolic computation investigate coupled cubic quintic nonlinear schrodinger equations variable coefficients come twin core nonlinear optical fibers waveguides describing effects quintic nonlinearity ultrashort optical pulse propagation non kerr media lax pair equations obtained corresponding darboux transformation constructed one soliton solutions derived physical quantities amplitude velocity width initial phases energy respectively analyzed finally infinite number conservation laws also derived results might value ultrashort optical pulse propagation non kerr media
paper continuous wavelet transform cwt based filtering strategy utilized along hilbert transform modal identification reinforced concrete road bridge although wavelet based pre filtering prior hilbert huang transform published literature advantage uniqueness proposed method traditional hht hht lies ability bypass time consuming evaluation intrinsic mode functions imfs often produces spurious modes mode mixing achieved using modified form littlewood paley basis function whose compact support frequency domain helps filter signal leakage free frequency bands followed modal parameter estimation proposed identification algorithm first tested synthetic records closely spaced strong weak modes validate efficiency accuracy full scale reinforced concrete road bridge considered experimental validation results presented work clearly show effectively evaluate significant number modes helpful finite element model updating large structures finally advantage proposed method demonstrated comparing performance methods available literature
paper order assess risk network network security assessment process involved content detail mentioned research based support system platform security test evaluate research safety situation assessment prediction subsystem detailed design carry implementation paper network security issues detailed study neural networks knowledge focus evaluation methods calculation rules nerve network technology studied specific examples calculation demonstrated feasibility neural network evaluation model actual case pointed traditional methods paper focuses network security assessment based neural network technology extensive analysis proposed major modeling tool indicator system network security analysis application neural networks network security assessment optimize network genetic algorithm key parameter combination operated efficiency neural networks get better play
paper aimed determine stochastic response suspension bridge subjected spatially varying ground motions considering geometric nonlinearity bosphorus suspension bridge built turkey connects europe asia istanbul selected numerical example spatial variability ground motion considered incoherence wave passage site response effects importance site response effect arises difference local soil conditions different support points structure also investigated end study mean maximum variance response values obtained spatially varying ground motions compared specialised cases ground motion model seen component spatially varying ground motion model important effects dynamic behaviour bridge response values obtained general excitation case also includes site response effect causes larger response values homogeneous soil condition cases variance values calculated general excitation case dominated dynamic component deck asian side tower response values obtained site response effect alone larger response values obtained incoherence wave passage effects separately concluded suspension bridges sensitive spatial variability ground motion therefore incoherence wave passage especially site response effects considered stochastic analysis type engineering structures
paper literature surveys research methods access right swing motion analysis security risks studies shown security risks swing movement carried analyze hidden aspects objectivity sports injuries exercise complexity level definition insurance etc swing movement security policy learn successful experience modem athletic swing improve security risks technical level expand geographical characteristics highlight national brand enhance performances ornamental competitive reference research related fields
paper multi source geophysical geochemical geological remote sensing datasets used construct multi scale district deposit orebody scale geological models extract exploration criteria subsurface polymetallic exploration targeting luanchuan district china results indicate series region district scale trending thrusts controlled main polymetallic forming formed regional indosinian qinling orogenic events secondary trending district scale folds trending faults intrusive stock structure produced based thrust structure caledonian indosinian orogenic events ore bearing zones ore forming structures trending district scale trending deposit scale normal faults crossed controlled jurassic granite stocks space associated magma skarn polymetallic mineralization buffer distance ore forming granite stocks trending hydrothermal deposits surrounded jurassic granite stocks constrained trending trending faults buffer distance ore forming fault iii nine polymetallic four targets identified subsurface luanchuan district elsevier rights reserved
paper nylon used carbonisation agent instead pentaerythritol melt intercalation method used synthesise polypropylene nylon montmorillonite mmt flame retardant nanocomposites structure flammability property products characterised ray diffraction fourier transform infrared spectroscopy transmission electron microscopy thermogravimetric analysis tga cone calorimeter test limiting oxygen index vertical burning test results showed polymer chain intercalated mmt interlayer mmt dispersed matrix form intercalation get flaky texture appropriate content mmt composition mass use intercalated mmt increased tensile strength materials impact strength improved flame retardant properties tga showed char residue rate reached cone calorimeter experiments indicated peak heat release rate reduced comparison pure residue weight increased vertical burning test results indicated materials achieved grade
paper lla silk fibroin nano yarns papered modified electrospinning method combine give fiber reinforced sponge freeze drying suppose used bone tissue engineering fiber reinforce effective method increase strength materials lla biocompatibility slower degradation rate providing longer time new osteogenic tissue formation structure morphology composites observed scanning electron microscope sem showed interconnected porous structure fourier transform infrared spectrum ftir ray diffraction xrd used study determine chemical component composites crystal structure treated ethanol vapor scaffolds became water resistance ftir xrd analysis showed matrix composites transformed random coil alpha helical beta sheet structure
paper piezoelectric patches electrical circuits associated attenuate vibration flat panel resulting electrical network equivalent resistor inductor capacitor circuit performing tuned vibration absorber denoted piezoelectric resonator choice design parameters correct placement piezoelectric patches optimal electrical circuit elements assisted finite element simulation theoretical analysis measurements sound transmission loss modal analysis conducted demonstrate structural vibration control resulting sound insulation performance shown despite reduced mass piezoelectric resonator effective conventional damping low frequencies enables overall sound insulation system perform lower mass wider frequency range
paper several optimizations proposed enhance quality lane detection algorithms automotive applications considering diagonal directions lanes proposed limited hough transform newly introduces image splitting angle limiting schemes relax number possible angles line voting process addition unnecessary edges along horizontal vertical directions pre defined removed edge detection procedures increasing detecting accuracy remarkably simulation results shows proposed lane recognition algorithm achieves accuracy computing speed frame sec superior results previous algorithms
paper expansion method suggested establish new exact solutions fractional differential difference equations sense modified riemann liouville derivative fractional complex transform proposed convert fractional partial differential difference equation differential difference equation integer order aid symbolic computation choose nonlinear lattice equations illustrate validity advantages algorithm shown proposed algorithm effective used many nonlinear lattice equations mathematical physics applied mathematics
paper authors present polarisation dependent analytical model radio frequency linearity characteristics proposed lattice matched alinn aln gan metal oxide semiconductor high electron mobility transistor moshemt developed model includes charge controlled analysis derived triangular potential well approximation along spontaneous piezoelectric polarisation effects model accurately predicts threshold voltage two dimensional electron gas sheet charge density drain current transconductance cut frequencies different samples gate dielectric materials sio hfo alo full range gate drain bias detailed analysis linearity characteristics investigating key figure merit metrics second order voltage intercept point third order voltage intercept point third order input intercept point third order intermodulation distortion performed different gate dielectric thicknesses accuracy model results verified silvaco technology computer aided design numerical simulation results found satisfactory observed careful tuning device parameters dielectric constant dielectric thickness lattice matched alinn aln gan moshemt considerably improve device performance suitable high performance low distortion applications
paper concept power tracking systems highlighted overview old recent maximum power point tracking mppt methods available literature presented classified methods mathematically modeled presented way reader select appropriate method application comparative table presented end paper simplify classification different methods
paper development highly interactive low cost personal computer based data acquisition control system presented system includes embedded microcontroller based hardware open standards software software uses block diagram programming base theoretical design implementation control system makes programming simple fast important feature system execute embedded control without personal computer intervention facilitates implementation real time control additionally system capacity expand order create distributed monitoring control system using bus communication interface also shown paper implementation developed system different plants
paper focus put multi core branch bound algorithms solving large scale permutation based optimization problems investigate five work stealing strategies new data structure called integer vector matrix ivm strategies thread private ivm allowing local management set subproblems enumerated using factorial system strategies differ way victim thread selected granularity stolen work units intervals factoradics assess efficiency private ivm based approach five strategies extensively experimented flowshop scheduling permutation problem compared conventional linked list based counterparts obtained results demonstrate ivm based outperforms linked list based one terms cpu time memory usage number performed operations copyright john wiley sons ltd
paper idea combination variable separation approach extended homoclinic test approach proposed seek non travelling wave solutions calogero equation equation reduced dimensional nonlinear equations applying variable separation approach solves reduced equations extended homoclinic test technique based idea aid symbolic computation new explicit solutions obtained
paper test bench sonic logging tool proposed designed realize automatic calibration testing sonic logging tool test bench system consists host computer embedded controlling board functional boards host computer serves human machine interface hmi processes uploaded data software running host computer designed developed based multithreading dynamic linkable library dll multiple document interface mdi techniques embedded controlling board uses arm microcontroller communicates host computer via ethernet embedded controlling board software realized based embedded uclinux operating system layered architecture functional boards designed based field programmable gate array fpga provide test interfaces logging tool functional board software divided independent sub modules repeatedly used various functional boards integrated sub modules top layer layered architecture modularized design software system highly reliable extensible help designed system test conducted quickly successfully electronic receiving cabin sonic logging tool demonstrated system could greatly improve production efficiency sonic logging tool
paper truncated painlev analysis consistent tanh expansion cte method developed dimensional breaking soliton equation result soliton cnoidal wave interaction solution equation explicitly given difficult found traditional methods value jacobi elliptic function modulus soliton cnoidal wave interaction solution reduces back two soliton solution method also extended types nonlinear evolution equations mathematical physics
paper thermal decomposition process molybdenum concentrate vacuum thermodynamically analyzed decomposition mechanism system molybdenum mainly studied investigate analyze electronic properties different temperature simulation calculations mos surface mos surface density states electron density difference electronic orbital mulliken overlap population carried density functional theory dft formalism dynamics simulations results mos surface mos surface obtained temperature range phase transforming respectively interaction mos mos shows thermal decomposition mos mos react new bonds bond formed instead bond fracture experimental results thermal decomposition mos mos accordance thermodynamics theoretical calculation results initio molecular dynamics simulation results elsevier ltd rights reserved
paper thermal modeling analysis kwdouble stator switched reluctance machine dssrm presented thermal management essential step machine design since overheatedwindings coresmight destroy insulation lead failure themachine three dimensional finite element method fem used numerically calculate temperature distribution different parts machine furthermore include use water coolant computational fluid dynamics cfd utilized thermal performance prototype analyzed various load conditions prototype dssrm built results experimentally verified
paper three dynamic linear models main span suspension bridges studied models describe vertical torsional oscillations deck action lateral wind problems correspond situations midspan cable bands loosened midspan bands fixed one midspan band fixed loosened three corresponding eigenvalue eigenvector problems formulated analysed continuous dependence eigenvalues eigenvectors data proved analysis three eigenvalue eigenvector problems flutter carried reveals possible reasons collapse original tacoma suspension bridge
paper two quantum key agreement protocols proposed resist collective dephasing noise collective rotation noise respectively two protocols mainly utilize logical quantum states measurement correlation property multi particle entangled states delayed measurement technique moreover information leakage congenitally free trojan horse attacks use decoy state technology delayed measurement technique makes secure participant outsider attacks efficiency analysis shows two protocols efficient
paper voltage sag voltage total harmonic distortion thd distribution network studied proposed electrical network modeled electrical source line source impedances assumed electrical load network sample electronic load load rectifier bridge output terminal connected capacitor bank linear resistance distribution network power quality analyzed changing load impedance capacitor bank number load network voltage sag thd distribution network studied using pscad tlab software
paper address effect shell thickness core shell structure electrochemical photoelectrochemical cell pec measurements properties zno ins core shell nanowires nws objective elucidate mechanisms responsible extended photoresponse zno ins core shell nws solar radiation well aligned zno ins core shell nws fabricated indium tin oxide substrates using electrochemically grown zno nws cores electrodeposited ins shells samples structure characterized ray diffraction revealing mixed wurtzite tetragonal structures zno cores ins shells improvement structure increases ins shell thickness optical properties studied optical absorbance photoluminescence measurements showing optical properties featured type heterogeneous nanostructures constructed zno ins electrochemical impedance spectroscopy eis employed equivalent circuit model designed suggesting cell performances affected increasing ins shell deposition times mott schottky plots several parameters flat band potential free carrier concentration determined next pec measurements highest photocurrent density produced ins shell electrode prepared deposition time min reached applied potential agcl value times much measured zno nws one provided highest value solar hydrogen energy efficiency eta results encouraging suggest ins covered zno nws nanostructures valuable photo anodes order build cheap devices solar energy hydrogen generation devices hydrogen energy publications llc published elsevier ltd rights reserved
paper analyze effect local shunts photovoltaic solar cells experimental characterization distributed electrical simulations purpose developed quasi distributed electrical network based two diode circuit elementary units allows accounting resistive losses associated transport emitter fingers busbars local defects semiconductor electrical parameters equivalent circuit units calibrated according experiments performed multicrystalline silicon solar cells including samples feature local shunts due localized defects lead nonuniform distribution electrical optical properties distributed electrical simulations account degradation fill factor power conversion efficiency case local shunting moreover combining proposed tool thermal network possible estimate temperature distribution shunted solar cell analysis shows shunted cell operates hot spot conditions subject significant local overheating possibly lead permanent cell damages
paper conduct research development applications innovative concept modern architecture design green environmental protection perspective emergence development concept green building met need long term development chinese society also inevitable trend era development current situation due effect construction technology financing environment green building construction also certain problem popularization green buildings also certain difficulties development society progress theoretical research green building also constant innovation believe development prospect beautiful research proposes novel paradigm architecture design innovative meaningful
paper conduct research development optimization building road construction management system based enterprise mis platform establishment enterprise project management system application analysis paper introduces function main characteristics enterprise project management system discusses enterprise project management system development steps main function business plan management data establishment enterprise project management database best use enterprise project management product node enterprise project management data entry automated processing enterprise project management workload statistics explore enterprise plan management system application analysis introduced combine optimized mis building road construction tasks provides novel perspective
paper conduct research wireless sensor network management methods based runtime model deepening research scalability maintainability wireless sensor network become important target application promotion consider nodes randomly distributed monitoring area looking complete coverage area several disjoint nodes uses genetic algorithm optimize network survival time nodes corresponding coverage point view software engineering specific software system knowledge hidden program document model main content document procedures high level abstractions management network urgently needed additional research also conduct theoretical analysis wireless sensor network security enhancement methodology tradition game theory mathematical optimization approaches meaningful game theory interaction much decision making behavior according different subjects control information cognition capabilities novel method analysis numerical simulation shows method performed better compared related approaches future research conducted polish current method
paper consider estimation power spectrum noise corrupted spectrum samples uniform grids frequencies missing values propose two schemes based regularized nuclear norm minimization combination recent subspace identification algorithm proposed schemes estimate model order missing spectrum values one step robust large amplitude noise short data records although estimation problem cast spectrum estimation problem nonuniformly spaced measurements algorithms developed type data used identification example paper shows incomplete data formulation yields accurate results properties one proposed schemes illustrated application example concerned low pass modeling transformer current
paper consider use dimensional analysis modeling electromagnetic levitation braking problems described lorentz force law based maxwell equations illustrate underlying field problem formulate complete mathematical model simple academic example permanent magnet moving infinite plate constant velocity step step procedure employed dimensional analysis described detail given problem dimensionless model reduced number parameters obtained highlights dominant dependences invariant dimensional system employed using dimensionless model concise parametric study conducted illustrate advantages dimensionless representation displaying complex data efficient manner provide exhaustive study dependences lorentz force dimensionless parameters complete analysis give results generalized representation problem finally scaling laws derived illustrated based practical examples
paper constructed exploration target model volcanogenic massive sulfide hydro thermal deposits honghai district china using moderate resolution etm aster hyperspectral hyperion images high resolution images weights evidence wofe analysis concentration area fractal modeling methodology mapping steps etm images used extract hydroxyl iron oxide alterations identification linear ring fault structures prospective zones regional scale aster images used extract sio index kaolinite chlorite propylite potassium carbonate limonite alterations identification mineralization zones district scale hyperspectral hyperion images analyzed identify mineral components identification deposit zones district scale high resolution images used extract geological objects volcanic rocks integration linear ring fault structures cross validate multiple type alterations associations lithological strata based interpretation etm aster images alteration structural factors geological objects integrated mineral prospectivity mapping wofe analysis mineral prospectivity classified fractal modeling ring faults iron oxide alteration chlorite alteration silicification important exploration factors whereas carbonate alteration potassic alteration linear faults secondary exploration factors ten exploration targets recognized honghai district elsevier ltd rights reserved
paper describe array based hierarchical mesh refinement capability uniform refinement unstructured meshes efficient solution pde using finite element methods multigrid solvers multi degree multi dimensional multi level framework designed generate nested hierarchies initial coarse mesh used variety purposes multigrid solvers preconditioners solution convergence verification studies improve overall parallel efficiency decreasing bandwidth requirements loading smaller meshes memory refinement also describe high order boundary reconstruction capability used project new points refinement using high order approximations instead linear projection order minimize provide control geometrical errors introduced curved boundaries capability developed parallel unstructured mesh framework mesh oriented database moab tautges describe underlying data structures algorithms generate hierarchies parallel present numerical results computational efficiency effect mesh quality also present results demonstrate applicability developed capability study convergence properties different point projection schemes various mesh hierarchies multigrid finite element solver elliptic problems published elsevier ltd
paper describe designed tested system automated double ring infiltrometer dri developed using arduino microcontroller hall effect sensor peristaltic pump water level sensor constant level float valve system used infiltration measurements single ring falling head double ring constant head methods precise measurements current method compared previous designed systems affected sunlight due method flow measurement remain accurate even low infiltration values set easy real time data storage micro card without need portable computer field requires single reservoir inner outer rings water added anytime needed without affecting measurements system automatically detects steady state infiltration rate reached concludes testing stops measurements system mounted portable weather resistant box applied run dri testing field check applicability accuracy portable set field measurements manual testing also performed field comparison automated system measurements overall system architecture design hardware software components presented details system configuration illustrated better understanding set published elsevier
paper detail two side channel attacks mceliece public key cryptosystem exploiting timing differences patterson decoding algorithm order reveal one part secret key support permutation first one improving two existing timing attacks uses correlation two different steps decoding algorithm improvement deployed error vectors hamming weight smaller quarter minimum distance code second attack targets evaluation error locator polynomial succeeds several different decoding algorithms also give appropriate countermeasure
paper develop optimal sleep wake scheduling algorithms smart mobile devices powered batteries capable harvesting energy environment using novel combination two timescale lyapunov optimization approach weight perturbation first design optimal sleep wake scheduling algorithm osa require knowledge harvestable energy process prove osa able achieve system performance within epsilon optimal explicitly compute required battery size epsilon extend results incorporate system information algorithm design specifically develop information aided osa algorithm iosa introducing novel drift augmenting idea lyapunov optimization show iosa able achieve epsilon close optimal utility performance ensures required traffic buffer energy storage size log epsilon high probability
paper elaborate premises studying problem substance use treatment disparities among migrants ethnic minorities due growing medicalisation research problem substance use disparities group policy makers health researchers practitioners often feel compelled rely epidemiological studies grounding understanding link ethnicity problem substance use treatment disparities argue bulk epidemiological research suffers crucial methodological conceptual flaws necessitate reconsideration usefulness policy treatment practice first epidemiological research based static concepts ethnicity race primordial analytical categories second consequence first argument research rarely distinguishes sufficiently ethnic non ethnic determinants mechanisms influencing problem substance use treatment disparities third studies often depart methodological individualism subordinate contextual structural determinants mechanisms paper aims evaluate factors mechanisms mediating relationship ethnicity nature problem substance use treatment disparities overcome gaps existing research methods mentioned specifically implies critical revision ethnicity concept epidemiology inclusion non ethnic determinants mechanisms means applying intersectional analysis ethnic boundary making perspectives broadening methodological individualism order include levels micro macro loci individual community society research holistic research designs doubled research allows researchers analyse impact treatment disparities among migrants ethnic minorities
paper explore entrepreneurial leadership strategies routine work actors located across diverse array organizational settings farmers markets community farms community supported agriculture programs food seed banks local food print media combine shape sustain southern arizona local food system lfs use theoretical principles institutional entrepreneurship logic multiplicity show strategies routine work local food actors organizational level combine negotiate system level meaning structure within across southern lfs otherwise seemingly fragmented contentious social space illustrate entrepreneurial work performed within multiple organizations organizational types converge form hybrid blended local food logic implications discussed recommendations practice proposed
paper find exact solutions nonlinear evolution equations using generalized tanh coth method three nonlinear models physical significance cahn hilliard equation allen cahn equation steady state equation cubic nonlinearity considered exact solutions obtained general solutions well known results also derived also paper shall compare generalized tanh coth method generalized expansion method solve partial differential equations pdes ordinary differential equations odes abundant exact travelling wave solutions including solitons kink periodic rational solutions found solutions might play important roles engineering fields generalized tanh coth method used construct periodic wave solitary wave solutions nonlinear evolution equations method developed searching exact travelling wave solutions nonlinear partial differential equations shown generalized tanh coth method help symbolic computation provides straightforward powerful mathematical tool solving nonlinear problems
paper focus detecting special type anomaly wireless sensor network wsn appears simultaneously collection neighboring nodes lasts significant period time existing point based techniques context effective efficient proposed distributed segment based recursive kernel density estimation global probability density function tracked difference every two periods time continuously measured decision making kullback leibler divergence employed measure order implement distributed network estimation lower communication cost several types approximated divergence proposed meantime entropic graph based algorithm operates manner centralized computing realized comparison proposed divergence based algorithms finally algorithms evaluated using real world data set demonstrates able achieve comparable performance much lower communication cost
paper focus resource conservation model decentralized management groundwater rainwater show conservation policy may opposite effects level resource depending outcome decentralized management precisely consider identical farmers use two water resources groundwater rainwater study symmetric asymmetric feedback stationary nash equilibria dynamic game show subsidy use rainwater may increase level aquifer symmetric equilibrium whereas decreases level aquifer asymmetric equilibrium suggests usual focus interior symmetric equilibria dynamic games may provide misleading policy implications
paper focus tackling problem automatic accurate localization detected objects high resolution remote sensing images two major problems object localization remote sensing images caused complex context information images contain achieving generalizability features used describe objects achieving accurate object locations address challenges propose new object localization framework divided three processes region proposal classification accurate object localization process first region proposal method used generate candidate regions aim detecting objects interest within images generic image features local image corresponding region proposal extracted combination model reduction convolutional neural networks cnns finally improve location accuracy propose unsupervised score based bounding box regression usb bbr algorithm combined nonmaximum suppression algorithm optimize bounding boxes regions detected objects experiments show dimension reduction model performs better retrained fine tuned models detection precision combined cnn model much higher single model also proposed usb bbr algorithm accurately locate objects within image compared traditional features extraction methods elliptic fourier transform based histogram oriented gradients local binary pattern histogram fourier proposed localization framework shows robustness dealing different complex backgrounds
paper introduce highly optimized software implementation standards compliant elliptic curve cryptography ecc wireless sensor nodes equipped bit avr microcontroller exploit state art optimizations propose novel techniques push performance envelope scalar multiplication nist curve illustrate performance ecc software develope prototype implementations different cryptographic schemes securing communication wireless sensor network including elliptic curve diffie hellman ecdh key exchange elliptic curve digital signature algorithm ecdsa elliptic curve menezes vanstone ecmqv protocol obtain record setting execution times fixed base point variable base double base scalar multiplication compared related work ecdh key exchange achieves performance gain roughly best previously published result using nist curve platform ecdsa performs twice fast ecdsa implementation well known tinyecc library also evaluate impact karatsuba multiplication technique overall execution time scalar multiplication addition offering high performance implementation scalar multiplication highly regular execution profile helps protect certain side channel attacks results show nist compliant ecc implemented efficiently enough suitable resource constrained sensor nodes
paper introduce technique design cross coupled dispersive delay structures ddss arbitrary prescribed group delay controlled magnitude technique magnitude phase cross coupled ddss separately controlled design example provided illustrate method response synthesized coupling matrix proves validity design method
paper investigate joint beamforming power allocation multicell multiple input single output miso downlink networks goal maximize utility function defined ratio system weighted sum rate total power consumption subject users quality service requirements per base station power constraints considered problem nonconvex objective fractional form circumvent problem first resort virtual uplink formulations primal problem introducing auxiliary variable applying uplink downlink duality theory exploiting analytic structure optimal beamformers dual uplink problem efficient algorithm developed solve considered problem furthermore reduce exchange overhead coordinated bss large scale antenna system effective coordinated power allocation solution based statistical channel state information reached deriving asymptotic optimization problem used obtain power allocation long term timescale numerical results validate effectiveness proposed schemes show spectral efficiency energy efficiency simultaneously improved traditional downlink coordinated schemes especially middle high transmit power region
paper investigate dimensional coupled nonlinear schrodinger equations variable coefficients describe propagation optical beam inside two dimensional graded index nonlinear waveguide amplifier polarization effects certain transformation constraints bilinear forms bright one two soliton solutions obtained soliton propagation collision function gamma representing gain loss coefficient profile function nonlinearity coefficient graphically presented analyzed propagation distance one soliton shown maintain amplitude width propagation gamma constant choosing gamma function soliton amplitude width alter propagation periodic oscillating soliton observed gamma trigonometric function properties soliton collision revealed based two solitons elastic collision presented gamma constant gamma function two solitons amplitudes widths keep invariant collision elsevier rights reserved
paper investigate coupled cubic quintic non linear schrodinger equations describe effects quintic non linearity ultra short optical pulse propagation non kerr medium linear forms bright one two soliton solutions obtained hirota method symbolic computation via asymptotic analysis find bright two solitons keep original amplitudes widths velocities invariant collision except phase shifts virtue graphical analysis head overtaking collisions bright two solitons presented bound state soliton also observed breather like structures
paper investigate unreliability hub location planning mixed integer nonlinear programming model formulated optimally locating uncapacitated hubs fail site specific probability objective determine location hubs assignment demand nodes hubs minimize expected demand weighted travel cost plus penalty hubs fail linear version model developed using specialized flow network called probability lattice evaluate compound probability terms tabu search algorithm proposed find optimal near optimal solutions large problem instances parallel computing strategy integrated tabu search process improve performance experimental results carried several benchmark instances show efficiency linearized model heuristic algorithm compared standard hub median model disregards potential hub failures model produces solutions serve larger numbers customers lower cost per customer
paper investigate whether board independence impact likelihood company reports weaknesses internal controls using sample firm year observations spanning period establish several findings first document negative relation board independence disclosure internal control weaknesses also document negative relation stronger firms unitary leadership combined positions ceo chairman firms dual leadership next show board independence associated fewer account specific company level weaknesses finally show board independence associated timely remediation internal control weaknesses implementation auditing standard weakens effect board independence disclosure icw
paper model trajectory sea vessels provide service predicts near real time position given vessel time intervals explore necessary tradeoffs accuracy performance resource utilization explored given large volume update rates input data start building models based well established machine learning algorithms using static datasets multi scan training approaches identify best candidate used implementing single pass predictive approach real time constraints results measured terms accuracy performance compared baseline kinematic equations results show possible efficiently model trajectory multiple vessels using single model trained evaluated using adequately large static dataset thus achieving significant gain terms resource usage compromising accuracy elsevier inc rights reserved
paper obtain variational principle new coupled zakharov kuznetsov system semi inverse method based formulation new solitary wave solution easily obtained using ritz method obtained conditions must remain valid continuation new solitary solution solutions exist also studied collision dynamics waves case finally give numerical simulations complete study elsevier ltd rights reserved
paper perform comprehensive parametric study supercritical sco brayton cycle integration concentrated solar thermal cst plant main focus develop operational strategies cycle adapt fluctuations solar energy availability several cycle layouts analysed combined cycle comprising recompression reheat intercool found efficient cycle two key cycle parameters sco circulation rate splitting fraction sensitized net shaft power nsp output controlled manipulating two parameters cycle adapt heat input variations without affecting nsp output finding leads two operational modes flexible temperature mode ftm constant temperature mode ctm solar assisted case study used test proposed strategies auxiliary fossil fuelled back afb unit utilised solar energy insufficient general proposed solar assisted cycles ctm ftm able achieve highest fossil fuel savings respectively compared conventional cycle without solar found ftm ctm deal fluctuations solar thermal energy supply however ftm effective tolerating drops solar energy supply considerably outperforms lowering contributions afb unit thus even efficient conditions ctm still underperformed ftm term fossil fuel saving elsevier ltd rights reserved
paper present new dimensional like nonlinear partial differential equation construct lump solutions rationally localized directions space two dimensionally reduced cases proposed method work based generalized bilinear differential equation implies build lump solutions presented like equation special polynomial solutions aforementioned generalized bilinear equation since totally six free parameters resulting lump solutions get sufficient necessary conditions guaranteeing analyticity rational localization solutions using six free parameters two special cases plotted illustrative examples contour plots different determinant values presented show corresponding lump solution tends zero determinant approaches zero
paper present novel computing model called probe machine unlike turing machine fully parallel computing model sense simultaneously process multiple pairs data rather sequentially process every pair linearly adjacent data establish mathematical model nine tuple consisting data library probe library data controller probe controller probe operation computing platform detector true solution storage residue collector analyze computation capability model particular show special case revisit two complete problems graph coloring hamilton cycle problems devise two algorithms basis established model enumerate solutions problems one probe operation furthermore show implemented leveraging nano dna probe technologies computational power electronic computer based known far human brain question naturally arises future computer based outperform human brain ways beyond computational power
paper present novel model updating method damage detection multi story shear buildings severe earthquakes story stiffnesses explicitly presented incremental manner enables simple robust algorithm purpose identification story stiffnesses estimated modal data including natural frequencies mode shapes lower modes used proposed algorithm moreover sensitivity analysis natural circular frequencies incorporated reduce possible errors story stiffnesses identified iterative algorithm window shift technique adopted present change story stiffness due damages buildings earthquakes numerical examples demonstrate proposed method high accuracy even recorded responses polluted relatively high level white noises copyright john wiley sons ltd
paper present simple efficient method represent terrains elevation functions built linear combinations landform features atoms features extracted either real world data sets procedural primitives combination multiple terrain models approach consists representing elevation function sparse combination primitives concept call sparse construction tree blends different landform features stored dictionary sparse representation allows represent complex terrains using combinations atoms small dictionary yielding powerful compact terrain representation synthesis tool moreover present method automatically learning dictionary generating sparse construction tree model demonstrate efficiency method several applications inverse procedural modeling terrains terrain amplification synthesis coarse sketch
paper present tuning methodology simple offset free siso model predictive controller mpc based autoregressive models exogenous inputs arx models arx models simplify system identification identified data using convex optimization furthermore proposed controller simple tune one free tuning parameter two features advantageous predictive process control simplify industrial commissioning mpc disturbance rejection offset free control important industrial process control achieve offset free control face unknown disturbances model plant mismatch integrators must introduced either estimator regulator traditionally offset free control achieved using brownian disturbance models estimator paper achieve offset free control extending noise model filter containing integrator filter first order arma model simulation analysis argue independent parameterization underlying linear plant tuning traditional disturbance models system dependent using insight present mpc siso systems based arx models combined first order filter derive expressions closed loop variance unconstrained mpc based state space representation innovation form use expressions develop tuning procedure regulator establish formal equivalence gpc state space based set free mpc simulation demonstrate procedure third order system offset free arx mpc demonstrates satisfactory set point tracking rejection unmeasured step disturbance simulated furnace long time delay elsevier ltd rights reserved
paper present evaluate new approach communicate inter integrated circuit enabled circuits sensors near field communication nfc nfc interface designed using non standard nfc command control bus directly smartphone controlling read write operations bus nfc interface reporting back data bytes bus smartphone transaction completed successfully proposed system tested experimentally write read requests commercial microcontroller featuring hardware port well reading commercial enabled humidity temperature sensor present experimental results system show approach enables easy interface smartphones external sensors interfacing external sensors useful beneficial smartphone users especially certain types sensors available smartphones
paper present branching oriented system equation based line error correction scheme recursive digital signal processing target digital signal processing linear time invariant algorithm includes multiplications constant coefficient additions delays difficulties algorithm level fault tolerance algorithm without structural regularity include error distribution problem right timing error correction escape error distribution problem multiple fan nodes algorithm specified nodes error corrections performed branching oriented graph branching oriented system equation introduced formulate line correction schemes based strategy branching oriented graph treated collection computation sub blocks applying checksum code independently sub block trivial line error correction scheme results appropriate selection error identification process tmr sub block level one advantages method reduction redundant operations performed merging computation sub blocks hand schedulability system important issue method since line error correction mechanism induces additional data dependencies paper schedulability condition modifications scheme also discussed
paper propose communication support tool understanding emotion unstable narrowband network tool support mutual understanding playing selected voice using also character based communication tool voice data transmitted asynchronously stored local storage proposed tool evaluated questionnaire survey using web based voice contents classified according massage types primitive emotion questionnaire survey results discuss effectiveness emotional voice message displaying text message
paper propose flexible mixed integer linear programming formulation opf problem distribution systems using convexification linearization techniques proposed formulation allows representation discrete decisions via integer decision variables captures nonlinear behavior electrical network via approximations controllable accuracy solved global optimality commercial optimization solvers formulation based conventional variables describe network behavior ensures flexibility possibility application various distribution system problems indicate case studies
paper propose new public key scheme combination rsa variant namely drsa generalization generalized discrete logarithm problem generalized gdlp security scheme depends equally integer factorization discrete logarithm problem dlp product two large primes multiplicative group modulo scheme randomized algorithm least secure drsa elgamal schemes also compare encryption decryption performance proposed scheme rsa drsa schemes
paper propose novel fuzzy inference system picture fuzzy set called picture inference system pis enhance inference performance traditional fuzzy inference system pis positive neutral negative degrees picture fuzzy set computed using membership graph combination three gaussian functions common center different widths expressing visual view degrees positive negative defuzzification values synthesized three degrees picture fuzzy set used generate crisp outputs learning pis including training centers widths scales defuzzification parameters also discussed system adapted architectures mamdani sugeno tsukamoto fuzzy inferences experimental results benchmark uci machine learning repository datasets example control theory lorenz system examined verify advantages pis
paper propose persistent watermarking technique information systems supported relational databases back end persistency achieved identifying invariant part database remains unchanged operations associated applications achieve apply static data flow analysis technique applications watermark embedded invariant part database leading persistent watermark also watermark associated applications information system using opaque predicates obtained variant part database
paper propose four compressors flexibility switching exact approximate operating modes approximate mode dual quality compressors provide higher speeds lower power consumptions cost lower accuracy compressors level accuracy approximate mode well different delays power dissipations approximate exact modes using compressors structures parallel multipliers provides configurable multipliers whose accuracies well powers speeds may change dynamically runtime efficiencies compressors bit dadda multiplier evaluated standard cmos technology comparing parameters state art approximate multipliers results comparison indicate average lower delay power consumption approximate mode also effectiveness compressors assessed image processing applications
paper propose concept compute memory computation deeply embedded memory sram deep embedding enables multi row read access analog signal processing compute memory exploits relaxed precision linearity requirements pattern recognition applications system level simulations incorporating various deterministic errors analog signal chain demonstrates limited accuracy analog processing significantly degrade system performance means probability pattern detection minimally impacted estimated energy saving compared conventional system standard embedded memory parallel processing architecture target image
paper propose analyze ultra thin body box fdsoi technology suitability architectural solutions iot applications specifically autonomous wireless sensor nodes wsns iot applications extremely diversified strong need flexible solutions design architectural level also technological level moreover systems recovering energy environment challenged low voltage supplies low leakage functionalities detail paper ultra thin body box fdsoi characteristics results demonstrating technology could perfect option multidisciplinary iot devices back biasing capabilities low voltage features investigated demonstrating efficient high speed low leakage flexibility addition architectural solutions wsns microcontroller also proposed taking advantage ultra thin body box fdsoi characteristics full user applicative flexibility partitioned architecture always responsive part asynchronous wake controller wuc managing wsn current tasks demand part main processor application maintenance presented first results always responsive part implemented ultra thin body box fdsoi also exposed elsevier ltd rights reserved
paper prove many parallel communication topologies several parallel algorithms fractal properties leads idea strong connection classical parallel computing plausible computing fractal medium furthermore show parallel algorithms suitable incursive hyperincursive computation links parallel computing quantum computing possible fractal computing
paper provide technical note implementation symbolic euler lagrange transformation nonlinear progressive water waves implementation solution nonlinear steady waves eulerian description obtained transformed corresponding solution lagrangian description automatically consider four closure conditions single symbolic implementation derive eulerian lagrangian solutions order accomplish automatically symbolic computation propose trigonometry polynomial transformations convert hierarchical system differential equations different orders system algebraic ones symbolic computation solutions user prescribed order automatically obtained via multiple loops example fifth seventh order euler lagrange solutions obtained within min respectively
paper report series eighteen novel pyrimidine based thiourea compounds good excellent yields chemical structures heterocycles consist central pyrimidine ring phenyl substituted thiourea motifs enzyme inhibitory potential compounds investigated alpha glucosidase enzyme plays crucial role treating type diabetes mellitus compounds delivered better inhibition reference compound acarbose quantitative structure activity relationship synthesized compounds also studied
paper review previous research paper presenting scheme quantum key distribution performs authentication using quantum means authentication mechanism protocol runs along eavesdropping checking approach upgrade security properties especially man middle attack propose revised enhanced scheme probability detecting eavesdropping distinctly improved use prism tool model checker analyze security quantum system emphasize extent contribution particularly focus two security features capability participants protocol detect eavesdropping attempt valid knowledge gained shared key must minimized john wiley sons ltd
paper show reduce computation drazin inverses certain computable fields computation drazin inverses matrices rational functions entries consequence derive symbolic algorithm compute drazin inverse matrices whose entries elements finite transcendental field extension computable field algorithm applied matrices field meromorphic functions several complex variables connected domain matrices field laurent formal power series elsevier rights reserved
paper theoretically predict experimentally measure thrust efficiency biomimetic robotic fish propelled ionic polymer metal composite ipmc actuator physics based model consists ipmc dynamics hydrodynamics proposed simulation conducted order test thrust performance robotic fish novel experimental apparatus developed hydrodynamic experiments servo towing system ipmc fish swam self propelled speed external force averagely zero experimental results demonstrated theoretical model well predict thrust efficiency robotic fish maximum thrust efficiency recorded experimentally maximum thrust force recorded maximum speed recorded peak power recorded additionally optimal actuation frequency thrust efficiency also recorded maximum self propelled speed present method examining thrust efficiency may also applied studies types smart material actuated underwater robots
research application algorithm used computer aided design engineering cad cae structural optimisation based design studies agricultural machineries introduced developed algorithm put practice case study tractor mounted telescopic boom crane algorithm consists numerical experimental methods includes material testing three dimensional computer aided design finite element method fem based analysis procedures structural optimisation strategy physical prototyping physical testing design validation procedures following visual physical validation procedures carried case study crane physical prototype manufactured optimised design approved ongoing production study provides unique cad cae experimentally driven total design pathway similar products contributes research utilisation engineering simulation technology agricultural machinery design analysis related manufacturing subjects
research morphologies isothermal crystallization kinetics spherulite growth aliphatic polyketone polyamide blends studied single glass transition temperature determined composition dependence blends well described kwei equation strong intermolecular interaction two polymer components confirmed melting point depression isothermal crystallization kinetics analyzed basis avrami approach linear increase radii spherulites time observed compositions spherulites continued grow nearly identical growth rates increasing polyamide content size spherulites polyketone polyamide blends gradually decreased number spherulites blends increased
review article editor new routledge volume leadership practice research application describes foundation thematic attributes critical uniqueness leadership practice comparing related collective traditions leadership contrasting individualistic approaches emphasize leader psychology review highlights contributions chapter writer weaving tapestry emerging movement seeking find leadership people within practices springs
review article outline evidence linking attachment adversity psychosis premorbid stages disorder clinical forms better understand neurobiological mechanisms insecure attachment may contribute psychosis identify least five neurobiological pathways linking attachment risk developing psychosis besides well documented influence hypothalamic pituary adrenal hpa axis insecure attachment may also contribute neurodevelopmental risk dopaminergic oxytonergic systems well bear influence neuroinflammation oxidative stress responses consider neuroscientific behavioral studies underpin mentalization suite processes potentially moderating risk transition psychotic disorders particular mentalization may help individual compensate endophenotypical impairments integration sensory metacognitive information propose model embodied mentalization would lie core protective resilience response mitigating adverse potentially pathological influence neurodevelopmental cascade risk psychosis
review paper recent advancements multidimensional spatio temporal signal processing highly directional radio frequency antenna array based receivers discussed network resonant beamforming filters infinite impulse response iir recursive spatio temporal signal flow graphs reviewed concept network resonant pre filtering described modification existing phased timed array beamforming back ends achieve improved side lobe performance array pattern leading better interference rejection capabilities digital analog signal processing models described terms system transfer functions signal flow graphs example frequency response antenna array pattern simulations presented
study authors proposed introduction chemical sensors directly textile surfaces form conductive transmission parts using screen printing technique liquid vapour sensitive printing surface made use multi walled carbon nanotubes also evaluated carbon nanotubes show effective chemo sensory properties chemical agent leads changes electrical conductivity research concerned assessment sensor efficiency chemical incentives form selected fluids vapours best sensory properties observed polar vapour level relative resistance case vapours non polar fluids sensory reaction printed fabrics much weaker level relative resistance printed textile backings subjected influence fluid show immediate reaction case fluid vapour reaction occurs seconds detection presence dangerous chemical agents organic liquids vapour possible means structure composed sensors
study authors report first example spinal pseudarthrosis patient ochronosis describe application posterior surgery alternative approach combined anterior posterior surgery management pseudarthrosis ankylosed spine regardless etiology spinal involvement ochronosis produces loss flexibility ankylosis thoracic lumbar segments pseudarthrosis serious complication diseases present ankylosis spine however occurrence ochronotic spine reported previously evaluation progressive paraparesis year old man ochronosis revealed pseudarthrosis level circumferential dural sac decompression debridement disc space interbody fusion screw rod fixation done via posterior approach postoperatively patient exhibited marked recovery terms pain neurological status month follow able walk independently ochronosis included etiology pseudarthrosis aggravation back pain appearance neurological deficits already stable patient ankylosing disease pseudarthrosis suspected furthermore single stage posterior surgery may obviate need single stage staged anterior posterior surgical intervention patients pseudarthrosis thoracic lumbar spine
study new hyperbolic tangent model proposed analyzing adsorption kinetic solid solution interface important advantage proposed model ability predicate equilibrium time adsorption vital optimize cost adsorption system design ability new model modeling adsorption kinetic predication equilibrium time tested using generated data points based mixed order equation moe new model applied fitting reported experimental data obtained results show new model analyze experimental data well elsevier rights reserved
study non contact measurement method proposed estimate tension hanger cables using digital image processing digital images acquired vision based system using portable digital video camera camcorder used remotely measure dynamic responses chosen convenient cost efficient digital image correlation technique one digital image processing algorithms applied develop image processing algorithm image transform function used correct geometric distortion deformed undeformed images calculate subpixels motion vision based system caused external wind vibration camera location corrected considering fixed object image without additional sensors using algorithm dynamic response hanger cable resolution modal frequencies improved also confirmed dynamic characteristics hanger cables estimated cable shape attaching target elsevier ltd rights reserved
study railway suspension bridge modeled suspended beam train sequence moving sprung masses investigate bridge response subjected simultaneous actions moving load earthquake induced support motions total response suspended beam ground motions decomposed two parts pseudo static response inertia dynamic component pseudostatic displacement analytically obtained exerting support movements suspended beam statically governing equations terms inertia dynamic component well moving oscillators transformed set nonlinearly coupled generalized equations galerkin method conducting dynamic response analysis suspended beam subject moving vehicles multiple support excitations one needs deal nonlinear coupling vibration problems time dependent boundary conditions instead solving coupled equations inertia dynamic generalized system containing pseudo static support excitations moving oscillators study treats nonlinear coupled terms pseudo forces solves decoupled equations using newmark beta method incremental iterative approach take nonlinear coupling effects account numerical investigations demonstrate present solution technique available conducting dynamic interaction problem support excitations moreover non uniform seismic inputs may amplify responses suspended beam moving vehicles significantly effect often neglected assumption uniform seismic ground motions conventional design bridge structures
study seabed comprising numerous particles simulated using discrete element method express viscosity seabed material cohesion properties medium clay used trawl door defined series polygons researchers used catia software suite obtain polygon data trawl door first shape model trawl door established next mesh data exported text file used define polygon elements program reduce analysis time parallel computing general purpose computing graphics processing units used following taguchi experimental design method design parameters trawl door determined using three levels four factors including front fillet angle length depth trawl door angle attack average trawl door contact forces compared determine optimal trawl door design
study encryption algorithm uses chaos based box developed secure speed image encryption first new chaotic system developed creating box image encryption algorithm chaos based random number generator designed help new chaotic system nist tests run generated random numbers verify randomness new box design algorithm developed create chaos based box utilized encryption algorithm performance tests made next step new developed box based image encryption algorithm introduced detail finally image encryption application carried show quality strong encryption process security analysis performed proposed algorithm compared aes chaos algorithms according tests results proposed image encryption algorithm secure speed image encryption application elsevier ltd rights reserved
study based attribute password introduce new kind two factor authentication protocol various applications anonymous authentication privacy protection specifically proposal constructed introducing password authentication generic framework attribute based authentication consequently achieves two factor authentication also enjoys advantages attribute authentication password authentication simultaneously furthermore formally evaluate security proposed protocol present corresponding security model within detailed security proof proposal given copyright john wiley sons ltd
study cyclic behavior dynamic properties renusagar pond ash samples reinforced geotextiles studied pond ash samples collected upstream side pond ash embankment laboratory tests carried obtain material properties pond ash strain controlled cyclic triaxial tests carried reconstituted pond ash samples without geotextiles varying confining pressures kpa loading frequencies cyclic shear strain amplitudes woven geotextiles used reinforcing materials placed pond ash samples one three layers results show pond ash samples reinforced geotextiles exhibit better friction angle drainage properties liquefaction resistance may concluded pond ash reinforced geotextiles used effectively embankment construction material american society civil engineers
study feo graphene nanocomposite synthesized liquid phase precipitation method characterized using ray diffraction fourier transform infrared spectrometer synthetic feo graphene used heterogeneous catalyst activate persulfate efficiently degrade methylene blue target pollutant degraded sulfate radicals depending several parameters including persulfate feo graphene concentrations reaction temperature within min reaction time almost removed persulfate presence feo graphene degrees degradation found follow pseudo first order kinetic model feo graphene much better stability reusability free feo suggested reuse tests results demonstrate feo graphene activated persulfate promising technology remediation water pollution caused organic contaminants
study fractional order lambda fopi lambda speed control induction motor realized dspicf microcontroller suitable industrial applications voltage frequency control method used induction motor integer order iopi controller fractional order lambda controller coefficients optimized using response surface method main advantage fopi controller provide adjustable time frequency responses control system allowing fulfillment better well robust performance fopi controller less sensitive classical controller parameter controlled system changes fopi extra variable tune provides extra degrees freedom dynamic properties fractional order system iopi fopi lambda controller results compared fopi iopi settling times obtained second respectively fopi iopi overshoots approximately obtained value less fractional order lambda controller results better integer order controller
study doped iron oxide nixfe materials synthesized via epoxypropane assisted sol gel method varying molar concentration sol gel derived nixfe gels dried dried powder calcined upto degrees air min obtained calcined nixfe powders analyzed determine phase composition crystallite size specific surface area pore volume morphology via powder ray diffraction pxrd bet surface area analysis bet well scanning transmission electron microscopy sem tem obtained results synthesis characterization section indicate formation nixfe nanoparticles high specific surface area thermal reduction oxidation sol gel synthesized nixfe materials determined using high temperature thermogravimetry obtained results indicate amount released thermal reduction step degrees quantity produced splitting step degrees increases concentration inside iron oxide crystal structure increases highest amounts released mol produced mol case nifeo material
study quality collected rainwater downtown middle school rainwater harvesting system evaluated measuring physical chemical microbiological parameters dissolved oxygen chemical oxygen demand cod total nitrogen total phosphorus total coliform escherichia coli metals analysis shows collected water quality poor presents health considering high levels bacterial indicators detected harvested rainwater turbidity ntu coli cfu cfu study shows deteriorating water quality caused system contamination due absence maintenance based study proper operation maintenance generally simplest effective ways maintaining water quality
study define characterize saltwater upconing zone influence suzi suzi region around pumping well within significant rise saltwater freshwater interface occurs zone influence pumping well clearly defined terms hydraulics drawdown suzi recognised characterised despite importance groundwater decision making coastal regions explore suzi various conditions compare common methods investigation using axisymmetric vertical cross section simulations saltwater upconing field scale based combination numerical analytical approaches suzi found dependent relative magnitudes pumping regional flow distance well coast position well interface expected three dimensional coastal setting simulations revealed asymmetric shape lateral extent suzi largest direction parallel coast occurs ocean inland extent seawater wedge limit propagation suzi perpendicular coast predictions suzi using ghyben herzberg approximation including cases sloping interfaces occur contrast artificiality horizontal interfaces used axisymmetric approaches provide reasonable first approximations suzi numerical modelling dispersive upconing inclined interface case influenced practical limits model domain size grid resolution example flow boundary condition pumping well elongates suzi direction parallel coast study extends previous concepts well interference previously based hydraulics introducing suzi characterising extent consideration given differences commonly adopted methods upconing quantification elsevier ltd rights reserved
study demonstrate concept new hybrid energy harvesting system combing solar cells magneto thermoelectric generator mtg thermal energy harvesting silicon solar cell easily reach high temperature normal operating conditions thus heated solar cell becomes rapidly less efficient temperature solar cell rises increase efficiency solar cell air water based cooling system used surpass conventional cooling devices requiring additional power well large working space air water collectors develop new technology pairing active thermal backplane atb solar cell atb design based mtg technology utilizing physics order phase transition active ferromagnetic materials mtg cost effective conversion thermal energy electrical energy fundamentally different seebeck teg devices atb mtg addition energy conversion system good conveyor heat conduction convection therefore atb provide dual mode proposed hybrid energy harvesting one active convective conductive cooling heated solar cell another active thermal energy harvesting heat solar cell novel hybrid energy harvesting device potentially simultaneous energy conversion capability solar thermal energy electricity results presented used better understanding hybrid energy harvesting system integrated commercial applications
study investigate piezoresistive properties flexible strain sensitive multi walled carbon nanotubes mwcnts epoxy composites deformation sensor area tested digital image correlation dic quasi static uniaxial tension piezoresistive characteristics films investigated quantitatively electrochemical impedance spectroscopy eis wide range frequencies mhz scanning electron microscopy sem images confirmed mwcnts epoxy composites different cnt concentrations good homogeneity dispersion additionally order tailor piezoresistivity strain sensor equivalent circuit derived based impedance responses corresponding parameters extracted tensile strain compared traditional strain gauges higher sensitivity obtained particular concentrations close percolation threshold due tunneling effect non linear piezoresistivity observed low concentrations found sensors shows highest linearity correlation coefficient standard deviation cyclic readings found indicating high repeatability elsevier ltd rights reserved
study investigated effect songs offer non misogynous ambivalent portrayals intimate partner violence ipv participants exposed misogynous song ipv song critical ipv song offered ambivalent portrayal ipv results showed positive effects anti ipv song positive negative effects ambivalent portrayal participants beliefs violent relationship findings suggest context ipv portrayed considered evaluating impact media depicting ipv
study propose newly derived parameters phosphate ions context gromos force field parameter sets non bonded parameters used lead hydration free energy renders dihydrogen phosphate ion hydrophobic compared experimentally derived values making reparametrization phosphate moiety necessary phosphate species great importance biomolecular simulations crucial role backbone nucleic acids also represent one important types post translational modifications protein side chains integral part many lipids parametrization free dihydrogen phosphate hpo three derivatives methyl phosphate dimethyl phosphate phenyl phosphate leads conjunction previously updated charged side chains gromos parameter set new nucleic acid backbone parameters version widely used gromos protein post translational modification parameter set wiley periodicals inc
study report gut microbial composition predictive functional profiles zebrafish danio rerio fed control formulated diet cfd gluten formulated diet gfd using metagenomics approach bioinformatics tools microbial communities gfd fed rerio displayed heightened abundances legionellales rhizobiaceae rhodobacter compared cfd fed counterparts predicted metagenomics microbial communities picrust gfd fed rerio showed kegg functional categories corresponding bile secretion secondary bile acid biosynthesis metabolism glycine serine threonine cfd fed rerio exhibited kegg functional categories bacteria mediated cobalamin biosynthesis supported presence cobalamin synthesizers bacteroides lactobacillus though bacteria absent gfd fed rerio comparable level cobalamin biosynthesis kegg functional category observed could contributed compensatory enrichment cetobacterium based results conclude rerio suitable alternative animal model use targeted metagenomics approach along bioinformatics tools investigate relationship gluten diet microbiome profile gut ecosystem leading gastrointestinal diseases undesired adverse health effects published elsevier
study report two high resolution structures pyridoxal phosphate plp dependent enzyme kynurenine aminotransferase kat one native structure cofactor plp form bound lys highest resolution yet available kat angstrom resolution general plp dependent aminotransferase inhibitor aminooxyacetate aoaa covalently bound cofactor angstrom small conformational differences observed vicinity aldimine oxime linkage plp forms schiff base lys angstrom resolution native structure comparison native plp bound structures also report inhibition kat aoaa aminooxy phenylpropionic acid aopp ics respectively crystal structure enzyme complex inhibitor aoaa revealed cofactor plp form external aldimine linkage location oxime plp forms place native internal aldimine linkage plp native kat away position native internal aldimine free lys substantially retaining orientation native structure tyr active site observed two conformations structures
study sought clarify functions nonsuicidal self injury nssi relate duration nssi change time accomplish aim analyzed data obtained routine clinical evaluations completed within specialized acute care treatment program nssi specifically examined functions nssi vary patients duration nssi functions changed within patients time changes nssi functions related treatment outcomes neither internal social functions associated nssi duration patients controlling relevant covariates patients completing two admissions assessments internal social functions decreased similarly time although decrease internal functions longer significant controlling decreases nssi urges patients completed admissions discharge assessments internal social functions decreased course treatment larger decreases internal functions decreases types functions related improved treatment outcomes conclusion results suggest nssi functions generally stable across time although decreases nssi functions may relate clinical improvement elsevier ireland ltd rights reserved
study synthesized one type star shaped polyurethane spu star shaped poly caprolactone spcl containing different arm numbers soft segment diphenyl methane diisocyanate mdi well chain extender butylene glycol bdo hard segment proton nuclear magnetic resonance nmr confirmed chemical structure material differential scanning calorimetry dsc dynamic mechanical analysis dma results indicated melting temperature transition temperature trans spu decreased hard segment composition increase ray diffraction xrd results demonstrated increase crystallinity spu following raised arm numbers endowed high shape fixity six arm star shaped polyurethane wide melting temperature range resulted excellent triple shape memory effect vitro cytotoxicity assay evaluated osteoblasts alamar blue assay demonstrates copolymer possessed good cytocompatibility material potentially used new smart material field biomaterials
study used cultural dynamic model explain persistence hinoeuma superstition traditional japan men superstition avoid marrying women born hinoeuma year hinoeuma women parents avoided childbirth last hinoeuma year concern daughter would trouble finding husband future resulted large drop number babies born previous theoretical analysis hinoeuma superstition considered two alternative cultural factors believers nonbelievers present study considered third cultural factor half believer man half believer accepts hinoeuma woman wife parents half believers avoid childbirth hinoeuma years three cultural factors two possible outcomes population first outcome non believers become extinct population consisting believers half believers men refuse hinoeuma women mate choice parents attempt avoid childbirth hinoeuma years second outcome believers become extinct remaining population consists non believers half believers man refuses hinoeuma women parents avoid childbirth hinoeuma years prevent potential harm daughters birth control fails steady rate believers become extinct eventually superstition likely maintained mother stronger influence beliefs children father elsevier ltd rights reserved
work novel integrated biokinetic wastewater treatment wwt model based smoothed particle hydrodynamics sph method hydraulic model proposed significant outcomes work computation detailed spatial distribution compounds wwt basins quantification effects stirrer induced mixing evolution compounds sph meshfree particle method herein applied compute treatment plant reactor hydraulics characteristic feature sph describe fluid dynamics particles move along flow present wwt model takes advantage principle assigning compounds concentrations defined activated sludge model sph particles full scale treatment plant simulation variable stirrer induced mixing intensity denitrification basin performed spatial distribution compounds concentrations unknown unsteady flows computed analysed developed framework generic therefore expected applicable modelling chemical engineering processes influenced hydrodynamic effects author published elsevier ltd open access article license http creativecommons org licenses
work experimental study flow wells turbine naca profiles submitted unsteady directional flow presented experimental set department mechanical chemical materials engineering university cagliari dimcm simulate real operation wave energy conversion device based principle oscillating water column owc equipped wells turbine set consists piston controlled hydraulic system moves inside cylindrical chamber open top wells turbine placed piston movement generates airflow driving turbine experimental investigations carried proximity rotor blade using three dimensional aerodynamic probes perform careful characterization flow field upstream downstream turbine dynamic characteristic turbine terms dimensionless flow parameters also determined real entity hysteresis phenomenon highlighted phases acceleration deceleration unsteady flow turbine moreover existence appropriate correlation conventional dimensionless coefficients measurable reliable physical variable investigated elsevier ltd rights reserved
work electrical impedance spectroscopy applied alternative method floral origin determination unifloral honeys may supplement labeling according european legislation impedance measurements agreement data routine analyses allowed distinguish unifloral honey samples acquire information chemical physical properties conductivity ash content acidity equivalent electrical circuits extracted unifloral honey sample validated means electrical simulation every electrical component ben associated specific honey characteristic concluded method developed permits rapid easy determination honey floral origin sample preparation procedure required could used official control laboratories elsevier ltd rights reserved
work presented study use optical fiber solar concentrator daylighting addressing system buildings solar energy form light collected sun tracking parabolic concentrator system guided addressed chosen area building opportune fiber optics guiding structure solar lighting system optical fiber turns convenient point view energy saving terms respect environment resultant reduction greenhouse gas emissions day lighting moreover influence positively well degree improves visual quality comfort reducing example psychological sadness related seasonal affective disorder sad hybrid sunlight addressing near infra red systems development composed primary parabolic collector ppc concentrates solar light secondary flat optical reflector soe made series cold mirrors elements frequency selective visible range solar spectrum reflected light optical fiber bundles near infra red part solar spectrum transmitted feed photovoltaic cells get energy artificial lighting needs night frequency selection working area building illuminated without thermal load connected infrared portion solar radiation setting required ambient light output aid principles telecommunications antennas implemented procedure matlab sizing primary parabolic concentrator secondary reflector therefore defined point optimal positioning circular crown bundles optical fiber overall system cost also estimated considerations economic dimensioning system terms efficiency estimated annual medium energy saving expected time economic amortization discussed sunlight addressing system described possible avoid energy double conversion lighting building interiors conversion solar light electricity artificial light low efficiency lighting solution direct use sunlight preferred lighting rooms predominant diurnal occupancy classrooms libraries laboratories elsevier ltd rights reserved
work performance graphene based nanolubricant using stroke engine test rig investigated nanolubricant formulated using graphene nanoflakes engine oil meeting api api specifications addition graphene api results enhancement thermal conductivity degrees reduction coefficient friction moreover enhancement heat transfer rate engine also achieved presence graphene sem images piston rings collected engine operation show oil containing graphene decreases piston wear compared base oil without graphene elsevier ltd rights reserved
work develop automatic procedures computing high order polynomial expansions local stable manifolds equilibria differential equations method incorporates validated truncation error bounds maximizes size image polynomial approximation relative specified constraints precisely use manifold computations depend heavily scalings eigenvectors indeed study precise effects scalings estimates determine validated error bounds relationship eigenvector scalings error estimates plays central role automatic procedures order illustrate utility methods present several applications including visualization invariant manifolds lorenz fitzhugh nagumo systems automatic continuation scheme stable manifolds suspension bridge problem present work treat explicitly case eigenvalues satisfy certain non resonance condition royal dutch mathematical society kwg published elsevier rights reserved
work present first design implementation wait free hash map multiprocessor data structure allows large number threads concurrently insert get remove information wait freedom means threads make progress finite amount time attribute critical real time environments opposed traditional blocking implementations shared data structures suffer negative impact deadlock related correctness performance issues use atomic operations provided hardware therefore hash map utilized variety data intensive applications including within domains embedded systems supercomputers challenges providing guarantee make design implementation wait free objects difficult wait free data structures described literature particular wait free hash maps often becomes necessary sacrifice performance order achieve wait freedom however experimental evaluation shows hash map design average times faster traditional blocking design solution outperforms best available alternative non blocking designs large majority cases typically factor higher
work propose novel text mining approach assisting academic staff course design curriculum development activities proposed approach based mining textual content technical academic websites online forums find date challenging topics whose inclusion curriculum would enhance quality related courses offered higher education institutes specific applied method well established online forum field computer science stackoverflow com covers wide range computer programming topics currently contains million questions answers automatically analysed content determine topics broad categories according wikipedia serving crowd sourced classification scheme present results computer assisted analysis terms frequently occurring subjects topics discuss insight gained findings analysis
work hardware software architecture control engineering education proposed case study regarding greenhouse irrigation virtual process implemented specific process especially useful subjects related industrial automation since characterized mixed dynamics continuous discrete controlled programmable logic controller plc case need access real process always available practical exercises moreover developed scheme eliminates maintenance costs related real process important advantage academic institutions developed architecture industrial process simulation uses labview opc modbus solidworks schneider modicon plc control virtual processes developed example applied greenhouse fertirrigation control enables agricultural engineering students design irrigation control system control strategy implemented plc interacts virtual necessary actions order control appropriate variables process car process ifac international federation automatic control hosting elsevier ltd rights reserved
work model simulate superelastic response shape memory alloy wires springs subjected torsional loading constructed combining thermodynamics principles along preisach models following doraiswamy gibbs potential based formulation employed separate thermoelastic response shape memory alloys dissipative response dissipative part modeled discrete preisach approach rather beginning full three dimensional model solving non homogeneous shear stresses across specimen cross section strength materials approach directly model torsional response using experimentally measurable quantities torque angle twist developed model results verified experiments performed shape memory alloy springs three different temperatures model also used predict torsion response shape memory alloy wires different twists temperatures using experimental results one twist temperature case respectively torsional response three different wire diameters predicted using experimental data one diameter case published elsevier ltd
work new memristor based high pass filter amplifier topology suitable analog signal processing applications designed analyzed memristor used negative feedback element high pass filter input impedance inverting amplifier topology best knowledge first time literature memristor based active circuit adjustable gain constant cutoff frequency high pass filter characteristic examined dynamic analytic models given time domain analysis simulations done circuit gain total harmonic distortion inspected frequency domain shown results analytical dynamical models good agreement found filter distortion low operation frequencies
work novel electronic lock encode decode optical signals modulated using morse code conventions developed build smart home security system based internet things iot five topics interest research optical morse code encoder optical morse code decoder ambient light sensor circuit fuzzy controller cloud monitoring system take advantage light emitting components encoder readily available hand held mobile devices smart phones photoresistors microcontroller decoder transferring even without personal computer real time information lock uploaded cloud service platform helps users ensure home safety remote monitoring system using ambient light sensor fuzzy controller novel optical morse code based electronic lock experimental results show reliability system much improved means highly resistant different illumination conditions work environment therefore functions including coding emitting receiving decoding uploading cloud monitoring work well furthermore besides convenience cost reduction incorporating traditional keys smart phones consumer electronics proposed system suitable users ages user friendly operation interface
work novel surrogate assisted memetic algorithm proposed based preservation genetic diversity within population aim algorithm solve multi objective optimization problems featuring computationally expensive fitness functions efficient manner main novelty use evolutionary algorithm global searcher treats genetic diversity objective evolution uses together non dominated sorting approach assign ranks algorithm coupled gradient based algorithm local searcher back propagation neural network global surrogate model demonstrates provide reliable effective balance exploration exploitation detailed performance analysis conducted five commonly used multi objective problems one involving distinct features make convergence difficult toward pareto optimal front cases proposed algorithm outperformed state art evolutionary algorithms considered comparison assuring higher repeatability final non dominated set deeper convergence level higher convergence rate also demonstrates clear ability widely cover pareto optimal front larger percentage non dominated solutions compared total number function evaluations elsevier rights reserved
work voltage mode biquad filter realizing low pass band pass high pass characteristics presented proposed filter employs two fdcciis two grounded capacitors two nmos transistors provides electronic tunability control voltage applied gate nmos transistors act linear resistor furthermore proposed circuit still enjoys realization using low number active passive components requirement component choice conditions realize specific filtering functions high input impedance low active passive sensitivities performance simulation results using spice program given show performance filter verify theory copyright john wiley sons ltd
work integrated game theory approach developed coordination multi enterprise supply chains scs competitive uncertain environment conflicting goals different participants solved coordination contracts using non cooperative non zero sum stackelberg game leadership manufacturer stackelberg payoff matrix built nominal conditions evaluated different probable uncertain scenarios using monte carlo simulation competition stackelberg game players third parties solved nash equilibrium game novel way analyze game outcome proposed based win win stackelberg set pareto frontiers benefits resulting minlp tactical models illustrated case study different vendors around client results show coordinated decisions lead higher expected payoffs compared standalone case also leading uncertainty reduction elsevier ltd rights reserved
work bimetallic nanoparticles bovine serum albumin biomolecular scaffold bsa ptnps synthesized facile green method compared bsa ptnps bsa ptnps possess enhanced peroxidase like catalytic activity moreover bsa ptnps stable harsh conditions high temperature extreme environments high ionic strength well common biological matrixes prominent advantages enable bsa ptnps applied wide range fields bioassays serum glucose detection extracellular hydrogen peroxide monitor cancer cells labeling realized satisfying results linear range glucose determination limit detection lod released mcf cell stimulation calculated mol utilizing folic acid recognition element tumor cell could readily distinguished bsa ptnps lod mcf cell detection cells elsevier rights reserved
work analysis flying buttresses rampant arches means classical strength materials concepts performed since elastic theory applied masonry arches considerations limit analysis masonry arches boundary conditions must exposed well equilibrium mechanism masonry supports bending moments appliance analysis existing flying buttresses allows obtaining new conclusions behavior real role structures
work consider multitask learning problems clusters nodes interested estimating parameter vector cooperation among clusters beneficial optimal models adjacent clusters good number similar entries propose fully distributed algorithm solving problem approach relies minimizing global mean square error criterion regularized nondifferentiable terms promote cooperation among neighboring clusters general diffusion forward backward splitting strategy introduced specialized case sparsity promoting regularizers closed form expression proximal operator weighted sum norms derived achieve higher efficiency also provide conditions step sizes ensure convergence algorithm mean mean square error sense simulations conducted illustrate effectiveness strategy
work demonstrated successful construction metal free zero dimensional two dimensional carbon nanodot cnd hybridized protonated pcn cnd pcn heterojunction photocatalysts means electrostatic attraction experimentally found cnds average diameter uniformly distributed surface pcn using electron microscopy analysis cnd pcn sample cnd content showed highest catalytic activity photoreduction process visible simulated solar light process results evolution total amounts generated cnd pcn photocatalyst visible light activity found mol catalyst respectively values times higher respectively amounts generated using pcn alone corresponding apparent quantum efficiency aqe calculated furthermore cnd pcn sample demonstrated high stability durability four consecutive photoreaction cycles significant decrease catalytic activity significant improvement photoactivity using cnd pcn attributed synergistic interaction pcn cnds synergy allows effective migration photoexcited electrons pcn cnds via well contacted heterojunction interfaces retards charge recombination confirmed photoelectrochemical measurements steady state time resolved photoluminescence analyses first principles density functional theory dft calculations consistent experimental results showed work function cnds larger pcn suggests efficient shuttling electrons conduction band pcn cnds hampers recombination electron hole pairs significantly increased probability free charge carriers reducing overall study underlines importance understanding charge carrier dynamics cnd pcn hybrid nanocomposites order enhance solar energy conversion
work present novel architecture field programmable gate array fpga accelerating image processing algorithms based conformal geometric algebra cga implementation specifically accelerates execution conformal geometric algebra voting scheme detection circles lines images geometric operations meet join transformation entities computed hardware using fpga non geometric operations dbscan also executed fpga full voting scheme consists two main stages local stage computed using neighborhoods image global stage using results local voting stage implementation focused computationally demanding stage local voting top level design consists five main hardware cores arm processor interconnected using axi bus cores exchange data using memory sections dram directly connected processing system side fpga accessed hardware cores memory controller using high performance axi bus design validated comparing results fpga results previously obtained software reference application using real image data
work present aeroelastic model intended three blade large scale horizontal axis wind turbines model results coupling existing aerodynamic model structural model based segregated formulation derived index based notation enables combining different descriptions rigid body dynamics assumed modes techniques finite element methods developed structural model comprises supporting tower nacelle contains electrical generator power electronics control systems hub blades connected rotating shaft three blades extract energy wind flexible blades discretized beam finite elements flexible tower discretized assumed modes nacelle hub considered rigid illustrate flexibility structural modeling tower nacelle hub modeled single kinematic chain blade modeled separately establish blade hub attachments use constraint equations thus resulting equations differential algebraic also expose general procedure connecting non matching structural aerodynamic meshes finally present results validations prove new approach reliable capability capture non linear phenomena centrifugal stiffening flutter large yaw errors remaining ones correspond aeroelastic response wind turbine start maneuvering elsevier ltd rights reserved
work present two detailed problems topological errors spatial database issues inconsistencies database interior topological relationships layers buildings relationship buildings layer layer plots inconsistency related residual polygons arise result overlapping objects gaps objects occurrence type error causes inconsistency spatial databases authors present two algorithms indicating elements inconsistencies base
work study solution sensibility recently introduced measurement based approach design approach coefficients function design parameters obtained measurements solution coefficients sensibility analyzed experimental electrical circuits made voltage source resistors
three phase induction motor drives addition certain zero sequence signal divides null vector time equally two zero states known improve harmonic performance sinusoidal modulation similarly split phase induction motor spim drives also addition zero sequence signal set three phase sinusoidal modulating waves leads reduction total harmonic distortion thd motor current however method known double zero sequence injection pulse width modulation dzipwm significantly inferior four dimensional sector space vector pulse width modulation dsec pwm terms thd paper investigates attempts determine zero sequence signal whose injection could result harmonic performance comparable dsec pwm zero sequence signal determined shown quite different used dzipwm analytical findings used propose computationally efficient carrier based approach implement dsec pwm whose implementation otherwise highly resource intensive feasibility computational efficiency accuracy proposed approach demonstrated validated split phase motor drive controlled field programmable gate array platform paper enables good harmonic performance split phase drive low computational effort resources
today world power consumption burning issue research going find various new power efficient design techniques power dissipation could reduced transforming continuous time current steering circuits discrete time charge steering circuits charge steering shows potential emerge effective technique reduce power dissipation high speed circuits technique exploited design analog semi analog circuits amp latches clock data recovery cdr circuits paper discusses design techniques charge steering circuits like amp latches stage stage amp circuits different type latches single stage cascade forms designed power performances charge steering circuits also compared conventional design techniques like current mode logic cml circuits show improvements results show amp power dissipation reduced approximately better gain circuits designed using umc cmos technology
today world high power computing applications image processing digital signal processing graphics robotics require enormous computing power applications use matrix operations especially matrix multiplication multiplication operations require lot computational time also complex design use field programmable gate arrays low cost hardware accelerators along low cost general purpose processor instead high cost application specific processor applications work employ efficient strassen algorithm matrix multiplication highly efficient run time reconfigurable floating point multiplier matrix element multiplication run time reconfigurable floating point multiplier implemented custom floating point format variable precision applications efficient combination karatsuba algorithm urdhva tiryagbhyam algorithm used implement binary multiplier design effectively adjust power delay requirements according different accuracy requirements reconfiguring run time
traditional teaching methods teaching science engineering students lack experience applying physical principles real time physical situation required disciplines study students engaged create interest learning interactive activities lack interest combined shortage practical experience learning eventually leads failure keep grades expected even lead increased rates attrition science engineering disciplines overcome problem present novel versatile interactive learning tool using data logging capabilities robotic educational module lego nxt present work describe method robotics based educational tool study electrical conductivity liquids body resistance newton law cooling details method designing building robo based physical system programming data collection analyzing data calculating interpreting results given method demonstrated undergraduate student participants summer camps robotics based educational tool used teaching learning extended several areas science engineering
two european countries different prevalence depression namely denmark high spain low assessed whether mediation effect emotional eating depression body mass index bmi found earlier studies replicated whether mediation effect contingent change appetite gender mediation moderated mediation assessed hayes process macro spss emotional eating debq dutch eating behavior questionnaire depressive symptoms ces center epidemiologic studies depression scale change appetite weight height self reported countries emotional eating acted mediator depression bmi denmark spain denmark mediation effect stronger participants increased appetite females participants decreases change appetite males appetite decreased appetite change appetite females males supports depression atypical features underlying mechanism mediation effect emotional eating spain support depression atypical features underlying mechanism mediation effect neither moderated change appetite gender instead post hoc analyses suggested stress unemployment possible explanatory factor mediation effect stronger mediation effects unemployed employed people unemployed employed mediating effect emotional eating depressive symptoms body mass index countries suggests obesity interventions take emotional eating account elsevier ltd rights reserved
underground mining machine design predominantly dictated mine conditions individual customer desires partnership foresight energy fletcher company tasked design manufacture new roof bolting machine six independent drilling apparatus board capable drilling bolting roof ribs material handling objective produce machine capable drilling installing six bolts simultaneously limited number operators goal mine decrease time bolt cut improve safety level current roof bolting method improve efficiency improve bottom line cost entry development customer wanted four drills front machine dedicated installing roof bolts another two drills behind dedicated rib bolts dictated requirement latched controls would allow operator start drilling one hole latch controls able move next result design machine single platform six independent masts drillheads four masts strictly drilling installing roof bolts front platform two masts back platform rib bolts controls operator station include latch control drilling six head roof bolter allows fewer operators drill install roof rib bolts turn lowers miners roof exposure per cut design reduces operator exposure inherent pinch points rotary hazards engaged latch drilling therefore machine help decrease time bolt cut improving productivity enhancing ability operate machine safely published elsevier behalf china university mining technology open access article license http creativecommons org licenses
view current shortage electric forklift hydraulic elevating mechanism new type hybrid forklift elevating mechanism proposed design calculation executed according maximum load elevating height elevating speed related design parameters time solid model elevating mechanism modeled catia software provide theoretical basis complete machine design hybrid forklift
view known sensitivity developing central nervous system pollutants sought assess effects exposure uranium heavy metal naturally present environment behavior young rats impact oxidative stress hippocampus pups drank form uranyl nitrate doses weeks birth control rats drank mineral water locomotor activity open field practice effects rotarod device decreased rats exposed respectively respectively compared control rats anxiety depressive like behavior altered exposure lipid peroxidation protein carbonyl concentration increased significantly exposure significant increase superoxide dismutase sod glutathione peroxidase gpx activities also observed hippocampus rats exposed results demonstrate exposure since birth alters behaviors modifies antioxidant status
view large number machining parameters influence system dynamics experimental study performed using boring trepanning association bta deep hole drilling process varying cutting parameters workpiece rotational frequency drilling feed rate tool usage considered input process specimens tested roundness considered output process study first order sugeno fuzzy models designed using cutting parameters input data roundness output data relation input output created find influence input parameters output surface quality terms roundness error hence best cutting condition deep hole drilling designated improve output scheme recommended precisely create relationship different cutting parameters using subtractive clustering procedure based first order sugeno fuzzy model minimum error model lesser numbers rules roundness error established enumerative exploration clustering parameters resulted model best clustering factors attuned using adaptive neuro fuzzy inference system anfis
view limitation construction management system intelligent management platform design proposed microsoft net intelligent client taken front end web service taken middle layer data sql server taken back end database management platform architecture selected testing results show system meets demand engineering construction enterprise project management
viticulture several applications bud detection vineyard images necessary task susceptible automated use computer vision methods common effective family visual detection algorithms scanning window type slide usually fixed size window along original image classifying resulting windowed patch containing containing target object simplicity algorithms finds challenging aspect classification stage interested grapevine buds detection natural field conditions paper presents classification method images grapevine buds ranging pixels diameter captured outdoor natural field conditions winter grape bunches leaves dormant buds without artificial background minimum equipment requirements proposed method uses well known computer vision technologies scale invariant feature transform calculating low level features bag features building image descriptor support vector machines training classifier evaluated images containing buds least pixels diameter approach achieves recall higher precision windowed patches covering whole bud scaled window patches containing proportion bud versus background pixels robustness position size window demonstrates viability use classification stage scanning window detection algorithms elsevier rights reserved
incidences food allergies rise greatly affect well children well adults intolerance gluten protein composite gliadin glutenin present wheat barley rye several cereals causative agent celiac disease allergic reactions gluten free diet become essential people affected consequently amount gluten food products needs strictly controlled paper report electrochemical label free immunosensor ultrasensitive specific detection gliadin sensor takes advantage specific properties porous reduced graphene oxide prgo covalently functionalized anti gliadin antibodies using pyrenecarboxylic acid linker molecule using differential pulse voltammetry dpv redox probe decrease current linked presence gliadin sensor achieved detection limit linear range high selectivity advantages offered sensor possibility regenerate surface immunosensor rapid ease production well applicability screening gliadin concentrations real food samples shown
incident angle light source key factor affects imaging resolution direct optical imaging reflected target large incident angle easy form blind area image object distinguished clearly using classical statistical optics study ghost imaging reflected object numerically experimentally show measuring second order correlation light fields ghost image good quality retrieved blind area unlike transmitted ghost imaging affected greatly transverse size test detector size almost effect resolution reflective ghost imaging blind area appears
inclined plane test widely used especially europe friction characterization geosynthetics liner systems example landfill applications however interpretation test complex less consensual direct shear test paper comprehensive analysis interface behaviour inclined plane device presented non woven geotextile geomembrane dry condition new test procedure proposed related parameters friction defined order properly characterise friction behaviour inclined plane shear strength geosynthetic interface characterised single parameter interface behaviour sensitive different kinematic conditions purpose comparison shown results complementary tests carried using shaking table test test procedures particular attention paid influence relative sliding velocity finally sensitivity interface mechanical damage caused large relative displacements quantified elsevier ltd rights reserved
incorporating quantity variety observations atmospheric oceanographic assimilation prediction models become increasingly complex task data assimilation allows uneven spatial temporal data distribution redundancy addressed models ingest massive data sets traditional data assimilation methods introduce kalman filters variational approaches study introduces family algorithms motivated advances machine learning algorithms provide alternative approach incorporating new observations analysis forecast cycle application kernel methods processing states quasi geostrophic numerical model intended demonstrate feasibility method proof concept speed efficiency accuracy scalability recovering unperturbed state trajectories establishes viability machine learning data assimilation
increase saturation natural clayey slopes along coastal zones result tsunamis storm surges may cause flow slides failures one common treatments increase overall stability soil replacement compaction often difficult implement expensive importantly damages natural vegetation paper remedial effectiveness relatively economical environmentally friendly method involving insertion geotextile strips drainage capability natural clayey slopes evaluated series centrifuge tests test results demonstrate effectiveness employed technique increase stability slopes drainage capability well reduce deformations surcharge loadings
increasing access long acting reversible contraception larc including intrauterine device implant public health clinical imperative reduce rates unintended pregnancy american college obstetricians gynecologists recommended methods women including adolescents little research explores young women reject safe effective contraceptive methods total women aged years completed depth interviews analytical techniques grounded theory approach used identify patterns themes across data participants initiated hormonal contraception pill beneficial side effects believed myth perfect use constructed false choice larc methods barriers larc options included access medical resistance cost participants described sense unease methods perceived alien women underestimated risks oral contraceptive pills overestimated risks long acting reversible contraception including infertility myth perfect use emerged participants wanted control taking pill every day however many described imperfect adherence findings include strategies public health professionals health care providers distribute satisfactory effective contraception young women effective health communication campaigns emphasize desirable side effects safety increased effectiveness larc methods
increasing quality requirements functional sports work wear make development demanding complex interaction human physiology clothing taken adequately account previous test designs often based subjective perceptions make convincing comparison difficult material specific laboratory tests offer limited validity regarding effects physiological ergonomic properties principal objective study compare two different types jackets respect effect core body temperature physical activity inactivity jackets filled different lining one chemically modified called quixdown one conventional climatic chamber test two activity sessions break performed subjects physically active bike ergometer moderate level total healthy physically active subjects years age randomly divided control treatment group equipped control group jacket ensure identical loading intensity test individual anaerobic threshold subject determined pretest person equipped ear thermometer measuring core body temperature acoustic meatus jacket subject core body temperature dropped less break activity sessions wearing jacket omega statistical significance could shown gender omega interaction jacket gender omega approximate chemically modified insulation seems offer better thermal insulation conventional authors published elsevier ltd selection peer review responsibility school aerospace mechanical manufacturing engineering rmit university
indentation size effect ise whereby strength materials observed increase significantly decreasing indentation depths reported several experimental studies present study series nanoindentation experiments maximum indentation depths varying carefully designed implemented study indentation size effect copper finite element analyses incorporating conventional mechanism based strain gradient cmsg plasticity theory requires solid elements performed simulate indentation size effect order circumvent ambiguity associated various methods evaluate indentation hardness indentation size effect investigated fundamental level considering changes load displacement curve finite element results incorporating cmsg plasticity theory found good agreement experimental results levels indentation depth conducted present study elsevier rights reserved
indium cadmium tin based transparent conducting oxide tco films low thermal emissivity values suitable energy efficient applications controlling thermal effect important factor among films antimony doped indium oxide iao coated glass explored resistivity similar omega film homogeneous good adherence glass even large dimensions film possesses emissivity similar taken standard calculation solar factor absorbed solar energy reradiated convected indoors transparent conducting oxide tco films types calculated values tco films ranges respectively attempt made use iao coated glass improve glazing system solar cooker principle lowering values would correspond significant increase heat insulation property thermal performance solar cooker box cover single layer low iao coated glass compared solar cooker box cover uncoated double glaze soda lime silicate sls glass initially finally solar cooker box evacuated glazed cover maintaining vacuum atrn glazing system thermal performance solar cookers ambient condition differs due variation heat flow glass cover different glazing systems perforinance promising solar cooker box cover single glazed low coated glass added advantages domestic usage low cost production relatively light weight high mechanical durability along relatively high thermal output published elsevier ltd
individual cross cultural factors associated attitudes toward homosexual people examined study using cross sectional data sixth biennial european social survey represents individuals nested within european countries successive nested models tested using multilevel modeling mlm results found attitudes varied cross culturally function people country residence clustering effect controlled subsequent models individual level predictors level male gender older age less education immigrant one residing country conservative political affiliation high religiosity perceptions politics one country unfair low openness change values low self transcendence values high conservation values high self enhancement values significantly linked anti homosexuality attitudes country level level high emphasis social conservatism fewer civil rights homosexuals connected unfavorable attitudes findings indicate main effects predictors levels however country level variables tended yield stronger coefficients individual level factors highlighting contributions macro microfactors simultaneously shaping attitudes toward homosexuality beyond effects interactions country individual level variables show political affiliation religiosity self enhancement values stronger predictors liberal countries openness change values younger age higher education stronger predictors conservative countries implications discussed understanding wide continuum views toward homosexuality across people countries
individuals autism spectrum disorder asd thought encounter planning difficulties experimental research regarding mastery planning asd inconsistent means meta analysis planning studies combined sample size individuals without asd aim determine whether planning difficulties exist factors contribute planning problems evident individuals asd hedges even taking publication bias account hedges neither age task type reduced observed heterogeneity suggesting crucial moderators within current meta analysis however showed asd individuals encounter planning difficulties bias towards publishing positive findings restricts strong conclusions regarding role potential moderators
individuals high levels hostility may susceptible influence television violence risk taking behaviors study aimed examine whether hostile personality trait modifies association viewing injuries prospective study black white adults aged cross lagged panel models analyzed three year time periods test whether viewing predicted injuries covariates gender race education individuals watched hours hours hours hours likely hospitalization injury following years across three follow periods cross lagged effects viewing injury significant high hostility group low hostility group additionally statistically significant difference two models suggested hostility moderated relationship watching injury findings suggest individuals watch hostile personality trait may greater risk injury
individuals obesity western societies often face weight related stigmatization social exclusion recurrent exposure prejudice negative social feedback alters one behavior future social interactions study aimed investigate autonomic nervous system affective responses social interactions individuals obesity women men without obesity participated episodes social inclusion social exclusion using virtual ball tossing game experiment heart rate measured parasympathetic activity overall high frequency power event related cardiac slowing analyzed results show novel social interactions women obesity relative groups exhibited strongest increase parasympathetic activity furthermore parasympathetic activity related negative body image individuals obesity lean individuals additionally women obesity reported stronger decrease mood social exclusion participants results demonstrate influences objective subjective bodily characteristics parasympathetic cardio regulation social interactions particular show behavioral physiological alterations social interactions women obesity
induction tolerance autoantigens vivo complex process involves several mechanisms induction regulatory cells changes cytokine chemokine profiles approach represents attractive alternative treatment autoimmune diseases apl altered peptide ligand derived novel cell epitope human heat shock protein kda hsp autoantigen involved pathogenesis rheumatoid arthritis shown previously peptide efficiently inhibited course adjuvant induced arthritis lewis rats induced regulatory cell treg vivo assay pbmc isolated patients study undertaken evaluate therapeutic effect apl combination methotrexate mtx collagen induced arthritis cia cia induced male dba mice weeks age immunization chicken collagen apl mtx administrated beginning arthritis onset therapeutic effect evaluated arthritis joint pathologic scores addition tnf alpha sera measured elisa treg induction assessed facs analysis apl inhibits efficiently course arthritis cia similar mtx addition therapy apl plus mtx reduced cia mice associated increase treg facts reinforce therapeutic possibilities apl candidate drug treatment
industrial design encompasses product development optimization production process sense ergonomics plays fundamental role principles methods techniques help operators carry tasks successfully case study carried industry shows interaction among design production engineering materials engineering departments may improve aspects concerned security comfort efficiency performance process ergonomics shown essential importance strategic decision making improvement production section
industrial linear drive systems many components due prolonged operations harsh working environment one components may degraded causing regular fault occurrences situation action taken system may collapse therefore quite important studying fault detection fault tolerant control control engineering paper fault tolerant control scheme based monitoring information proposed linear drive systems fault detection algorithm first presented subsequently fault identification developed finding characteristic detected fault finally fault tolerant controller discussed based soft computing
industrial process control holds great importance dealing nonlinear control system modeling controller design considered critical challenge researchers well plant operators resultantly significant amount research work prompted area adaptive control biggest advantage unknown system parameters tuned online adjusted adaptively research work adaptive controller based upon recently developed model suggested model simplified polynomial structure adaptively adjusts system parameters online less complex structure design development model based controller simple previously performed well different applications regarding system identification controller design motivates undertake gas process plant research work using model proposed control strategy verified simulation authors published elsevier
infant directed speech ids particular voice register observed majority parents interaction infants differs natural speech used conversations adults showing exaggerated prosodic features prosodic features supposed effects regulating infant arousal attention fostering infant pre linguistic linguistic competences enhancing expression positive affect present set meta analyses conducted test associations role moderators first two years infant life results confirmed overall association ids prosody infant outcomes prosodic values typical ids associated better outcomes association confirmed attentional pre linguistic linguistic outcomes greater effect pre linguistic linguistic outcomes insufficient number studies found test association infant emotion expression many limitations existing body literature found lack empirical papers exploring ids prosody relation infant outcomes using natural observations results limitations discussed light necessity examine interplay quality ids prosody aspects parental communicative care giving competences contribution scholars different fields needed aim fully understand multidimensional determinants influential mechanisms ids elsevier inc rights reserved
inferences moral character may often drive outrage symbolic acts racial bigotry study demonstrates theoretically predicted dissociation moral evaluations act person carries act although americans regarded private use racial slur less blameworthy act physical assault use slur perceived clearer indicator poor moral character study highlights dynamic interplay moral judgments acts persons demonstrating first making person judgments bias subsequent act judgments privately defacing picture martin luther king led greater moral condemnation agent act behavior evaluated first americans first made character judgments symbolically defacing picture civil rights leader significantly likely perceived immoral act studies support person centered account outrage bigotry demonstrate moral evaluations acts persons converge diverge theoretically meaningful circumstances copyright john wiley sons ltd
inferring pose character drawing complex constrained problem solving may help automate various parts animation production pipeline pre visualization article novel way inferring pose monocular sketch proposed proposed method make external assumptions model allowing used different types characters inference pose formulated optimization problem parallel variation particle swarm optimization algorithm called parac loapso utilized searching minimum testing isolation well part larger scene presented method evaluated posing lamp horse human character results show method robust highly scalable able extended various types models
inflammatory bowel disease ibd assumed caused genetic environmental factors interact together promoting intestinal immune dysregulation cytokines validated role however underlying intimate mechanisms human ibd involving cytokines still needs supplemented especially clinical context aim study investigate expression inflammatory regulatory cytokines tgf beta well transcription factor foxp mucosal samples ibd non ibd patients assessed mrna relative quantities mentioned cytokines transcription factor foxp paired colonic samples inflamed adjacent normal mucosa patients ibd normal mucosal tissue persons without ibd performing qrt pcr assay tested protein levels target cytokines serum samples patients divided three groups without therapy asa immunosuppressants azathioprine asa corticosteroids order compare values therapeutic group investigated genes found upregulated inflamed mucosa ibd patients following order foxp tgf beta also observed gene expression foxp substantially higher inflamed mucosal tissue ibd patients adjacent normal mucosa respectively differences higher mrna expression foxp inflamed tissue considered significant patients ulcerative colitis respectively crohn disease respectively comparison normal mucosa non ibd persons found increased tgf beta patients alone furthermore tgf beta overexpressed non inflamed mucosa ibd patients compared normal mucosa controls compared gene expression paired mucosa immunosuppressive treated group asa treated group observed opposite changes tgf beta expression additionally found higher serum levels tgf beta ibd patients compared non ibd patients obtained specific expression profile consisting tgf beta foxp may represent transcriptional hallmark ibd furthermore found treatment immunosuppressive therapy beneficial driving cytokine expression restore immune regulation patients ibd unlike asa therapy elsevier ltd rights reserved
inflammatory bowel disease ibd result chronic intestinal inflammatory response usually occurred colon small intestine keratins constitute intermediate filament cytoskeleton epithelia present study intended explore role keratin krt progress ibd normal intestinal tissue expression krt detected pcr western blot levels krt protein significantly decreased serum samples ibd patients compared sera healthy controls immunohistochemistry revealed expression krt decreased various intestinal diseases especially crohn disease ulcerative colitis furthermore regulated krt correlated severity ibd overexpression krt maintained epithelial barrier caco cells beta treatment furthermore beta induced disruption tight junction became significantly attenuated krt expressing caco cells compared control cells thus krt played important role maintaining epithelial barrier regulation intestinal tissue correlated progression ibd elsevier rights reserved
inflammatory bowel disease ibd results complex series interactions susceptibility genes environment immune system recently studies provided strong evidence process autophagy affects several aspects mucosal immune responses autophagy cellular stress response plays key roles physiological processes innate adaptive immunity adaptation starvation degradation aberrant proteins organelles antimicrobial defense protein secretion dysfunctional autophagy recognized contributing factor many chronic inflammatory diseases including ibd autophagy plays multiple roles ibd pathogenesis altering processes include intracellular bacterial killing antimicrobial peptide secretion paneth cells goblet cell function proinflammatory cytokine production macrophages antigen presentation dendritic cells endoplasmic reticulum stress response enterocytes recent studies identified susceptibility genes involved autophagy nod atgl irgm active research ongoing world aim review systematic appraisal current literature provide better understanding role autophagy pathogenesis ibd understanding mechanisms bring new strategies treatment prevention ibd
inflammatory bowel diseases ibds chronic diseases result inflammation intestinal wall suspected patient presenting intestinal symptoms recently diagnosis mainly based clinical endoscopic arguments use easy fast reliable non invasive inexpensive biological assay mandatory diagnosis also evolutionary therapeutic monitoring date fecal calprotectin documented perspective marker allows discrimination functional organic bowel processes good performance determination fecal calprotectin level contributes evaluation degree disease activity monitoring therapeutic response
inflammatory joint disease ijd group conditions target joints periarticular structures contribution genetic factors conditions often less suggesting major role environmental influences twin studies best means assessing role genetic factors ijd conclusive evidence provided studies vast samples monozygotic dizygotic twins one twin pair ijd studies successful ankylosing spondylitis psoriatic arthritis ijds proven difficult evaluate review demonstrates genetic environmental factors inextricably linked ascribing ijds one misguided awareness limitations possible sources bias twin studies important seeking understand development complex diseases published elsevier masson sas behalf societe francaise rhumatologie
inflammatory skin disorders cause serious deterioration quality life become one major public concerns despite significance fundamental cure date mesenchymal stem cells mscs possess unique immunomodulatory properties make promising tool treatment various inflammatory diseases recent preclinical clinical studies shown mscs successfully used treatment atopic dermatitis one major inflammatory skin diseases observation along similar reports groups revealed efficacy underlying mechanisms mscs inflammatory dermatosis addition proposed cell priming gene transduction novel strategies development next generation high efficacy mscs treating inflammatory skin diseases discuss existing evidence demonstrates regulatory properties mscs immune responses inflammatory conditions
inflammatory vulvar dermatoses affect many women likely underdiagnosed due embarrassment reluctance visit health care provider although itch pain common presenting symptoms physical examination help distinguish different disease entities many women health providers minimal training categorization management dermatologic disease definitive diagnosis management difficult herein strategies diagnosing vulvar lichen sclerosus lichen planus contact dermatitis lichen simplex chronicus psoriasis discussed along basic management diseases commonly involves decreasing inflammation behavioral change gentle skin care topical corticosteroids systemic therapies
infliximab ifx anti tumor necrosis factor alpha antibody used treat inflammatory joint diseases infusion reactions occur intravenous administration often require discontinuation ifx therapy retrospective study aimed evaluating incidence patients joint inflammatory diseases receiving ifx without premedication clinical charts rheumatoid arthritis psoriatic arthritis ankylosing spondylitis patients receiving ifx january december reviewed patients receiving one premedication protocol time enrolled clustered based type premedication follows group received premedication group received paracetamol esomeprazole hydrocortisone chlorpheniramine maleate group received paracetamol hydoxyzine ranitidine methylprednisolone adverse events recorded infusion following hours control visits charts patients treated ifx selected observed patients group patients group none patients group incidence significantly lower second third compared first group incidence significantly lower group group moreover patients group relative risk developing times higher group experience use premedication significantly reduced number ifx particular combination paracetamol hydroxyzine methylprednisolone ranitidine efficacious paracetamol esomeprazole hydrocortisone chlorpheniramine maleate combination protocol
informal care giving demanding role shown impact physical psychological social well methodological weaknesses including small sample sizes subjective measures mental health led inconclusive evidence relationship informal care giving mental ill health paper reports study carried region investigated relationship informal care giving mental ill health analysis conducted linking three data sets northern ireland longitudinal study northern ireland enhanced prescribing database proximity service index northern ireland statistics research agency analysis used subjective measure mental ill health question asked census objective measure whether respondents prescribed antidepressants general practitioner applied binary logistic multilevel modelling two responses test whether sub groups population informal care giving related mental ill health results showed informal care giving per related mental ill health although strong relationship intensity care giving role mental ill health females provided hours care employed worked part time provided care statistically significantly elevated risk mental ill health caregivers remote areas limited access shops services also significantly increased risk evidenced prescription rates antidepressants community care policies aimed supporting people remain home paper highlights need research order target resources appropriately
information communication technologies applied health care advances sensor data transmission technology allowed tele medicine based programs care also patients respiratory diseases different sensors transmission devices interventions used tele medicine indications patients suffering chronic obstructive pulmonary disease asthma neuromuscular diseases ventilator assisted individuals undergoing pulmonary rehabilitation programs may benefit approach legal problems still unsolved economic advantages health care systems though potentially high still poorly investigated despite hopes need evidence modality considered real progress management patients respiratory diseases one hand technologies improve care patients difficult access services particularly rural remote areas hand risk used reduce standard services health systems developed countries
information hiding technology important wireless sensor network security copyright protection paper uses rssi received signal strength indication hidden information carrier designs information hiding algorithm riha affect original data bring additional communication cost riha novel information hiding method suitable resource constrained wireless sensor networks simulation results show riha high hidden information transmission accuracy without bringing additional communication energy consumption riha provides new way information hiding technology wireless sensor networks
information security customers privacy smart grid significant concerns existing security privacy preserving schemes consider consumption reports electricity consumption aggregation billing purposes sent periodically periodic messages increase computation communication burden restricted capabilities smart meters paper propose lightweight security privacy preserving scheme based forecasting electricity demand cluster houses residential area limits cluster connection electricity utility cluster needs adjust total demand scheme efficiently satisfies security privacy requirements customer side networks communication customers power utility time significantly reduces communication computation overhead moreover proposed scheme utilizes ntru cryptosystem reduce computation complexity
infrared detectors core infrared imaging systems readout integrated circuits key components detectors order grasp performance circuits quickly accurately method circuit modeling using verilog language proposed present behavioral simulation model roic first typical capacitor trans impedance amplifier ctia roic unit showed two essential parts operational amplifier switch modeled behavioral level amp model concludes non ideal factors finite gain bandwidth product input output offset output resistance non deal factors affect switches considered switch behavioral model rise fall time resistance last time domain modeling method noise presented compared classical frequency domain method difference analysis results shows situation noise interested bandwidth nibw mhz difference two methods leads less sample rate noise larger times nibw
infrared thermography well established technique non destructive characterisation various materials technique relies analysis acquired temperature profile test sample evaluate presence surface sub surface anomalies within material past decade coded thermal excitation schemes associated post processing signal video processing schemes gained vital attention infrared thermographic community various fields however thermal non destructive testing usage coded excitations still relatively uncommon paper explores feasibility using complementary golay coded excitation active thermography newly developed technique shown effective increasing temporal signal noise ratio suppressing side lobes compressed pulse present experimental investigation emphasises defect detection capabilities golay coded thermal wave imaging characterise carbon fibre reinforced plastic material blind holes inclusions defects investigation spatial signal noise ratio also presented
infrastructure systems united states need urgent maintenance rehabilitations preservation culvert networks major component infrastructure systems acceptable level serviceability subject stringent yearly maintenance rehabilitation budgets major challenge culvert network owners managers decision makers required develop optimum financial plan minimize total cost maintenance rehabilitation different expected improvements culvert network performance given planning horizon manuscript presents discussion budget planning maintenance rehabilitation scheduling optimization culvert network maintenance rehabilitation expenditure justified net increase asset value cost rehabilitation net worth asset based performance rather book value government standards require owners maintain improve overall condition state infrastructure systems substantial annual investment paper three methods proposed compute long term annual investments culvert networks modified worst first method network optimization approach estimation maximum deterioration rate performance culvert system simulated using methods based simulation results modified worst first method computationally intensive provides optimum budget method using maximum deterioration rate provides lower bound value used absolute lowest value allocated optimization method uses computer programming provides upper bound value small networks anticipated large culvert networks network optimization approach used provide reasonable long term annual budgets three methods modified worst first method provided minimum long term annual budget consistent government requirements american society civil engineers
inhibitors synthetic natural molecules various functional groups like double triple bonds heteroatoms permit adsorption onto metal surface inhibitors ability adsorb onto block active site reducing corrosion rate inhibition efficiencies investigated compounds sulfacetamide sam sulfamerazine smr sulfapyridine spy sulfathiazole sti inhibitors corrosive solution evaluated based weight loss technique nitro amino groups chosen study substituted reaction four corrosion inhibitor compounds sam smr spy sti theoretically utilizing thickness capacities hypothesis dft density functions theory method level rblyp research demonstrated nitration studied molecules lead diminishing inhibition efficiencies group lead increase inhibition efficiency compared corrosion inhibitor molecules results gave significant improvement inhibition efficiency corrosion inhibitor molecules elsevier rights reserved
injuries articular cartilage remain difficult treat range small articular cartilage defects end stage severe osteoarthritis review discuss various surgical treatment options including imaging features associated complications specifically review microfracture acellular matrix induced microfracture autologous osteochondral transplantation osteochondral allograft transplantation autologous chondrocyte implantation along various forms knee arthroplasties
inner source use open source software development practices establishment open source like culture within organizations organization may still develop proprietary software internally opens development steady stream scientific literature practitioner reports indicates interest research area however research area lacks systematic assessment known research work model exists defines thoroughly various case studies provide insights programs context specific organizations publications apply broader perspective resolve performed extensive literature survey analyzed related publications plus additional background literature using qualitative data analysis methods developed model elements constitute present classification framework programs projects apply lay map known endeavors present qualitative models summarizing benefits challenges adoption survey provides first broad review literature systematic arrangement research results
innovation regarded means improving performance construction despite benefits management innovation difficult task measurement complicated comprehensive model comprising interrelated components construction innovation yet developed tested major objective research propose framework analyze construction innovation respect total factors associated innovation identified grouped six components namely drivers barriers enablers inputs project level benefits firm level benefits interrelations among components examined questionnaire survey data collected projects analyzed using structural equation modeling findings study suggest innovation decision governed factors specified drivers investment innovation results project level also firm level outcomes however hypothesized negative impact barriers found significant findings also reveal innovation major benefits increases productivity client satisfaction project level improvement company image improvement technical managerial capability gaining experience firm level research findings expected help project managers construction business devise proper strategies effectively implement innovation
innovative interventions address social determinants health required help reduce persistent health inequalities argue microcredit act way develop conceptual framework examine seeking evaluate microcredit way examine randomized controlled trials currently considered gold standard impact evaluations microcredit compare developments thinking study design public health leads challenge notion trials apparent gold standard microcredit evaluations contend pursuit trial based evidence alone may hampering production relevant evidence microcredit public health wider impacts introduce new insights global debate microfinance impact evaluation related ethical issues staging randomized controlled trials propose innovations complementary methods use evaluation complex interventions
insight refers situation problem solver immediately changes understanding problem situation representational change either triggered external stimuli like hint solution internal solution attempts present paper differences similarities two phenomena namely extrinsic intrinsic insight examined end electroencephalogram eeg recorded subjects either recognize generate solutions german verbal compound remote associate problems cra based previous studies compare alpha power prior insightful solution recognition alpha power prior insightful solution generation results show intrinsic insights preceded increase alpha power right parietal electrodes extrinsic insights preceded respective decrease results interpreted two ways consistency studies increase alpha power intrinsic insights interpreted increased internal focus attention accordingly decrease alpha power extrinsic insights may associated externally oriented focus attention alternatively increase alpha power prior intrinsic insights interpreted active inhibition solution related information alpha power decrease prior extrinsic insights may reflect activation regardless interpretation results provide strong evidence extrinsic intrinsic insight differ behavioral well neurophysiological level
inspired special properties graph state quantum authentication scheme proposed paper implemented utilization graph state two entities reliable party trent verifier alice prover included trent responsible registering alice beginning confirming alice end proposed scheme simple structure convenient realize realistic physical system due use graph state one way quantum channel addition security scheme extensively analyzed accordingly resist general individual attack strategies
instead classical obituary rich scientific results pavel holba survived emphasizing contribution underpinning determination hyperfree energy associated definition novel terms phtochability plutability well characterization equilibrium background processes impact kinetic data evaluation less important findings resolution impact heat inertia often forgotten effect influential dta kinetics known since newton cooling law attempts improve interrelation thermodynamics kinetics underlined
instrumentation amplifiers used wearable biomedical monitoring systems satisfy several performance requirements low voltage supply low power consumption enabling increased portability time important feature wide range parameter programmability paper proposes solution implement electronic gain programming proposed solution developed around current balancing concept electronically tunable transconductance amplifier used adjusting voltage gain function transconductor bias currents additionally proposed outputs differential signal useful latter differential analog signal processing simulation results validate proposed
insulated power cables critical devices used electrical network urban areas also lifespan knowledge devices important information decision makers make investment planning study presented practical method estimating remaining lifetime power cable validation method tested two different cases xlpe insulated underground power cable system power cable thermal network modeled short duration transient according electrical analogy lifetime monitoring carried considering loss life trend depending load raising annual basis results show accuracy remaining service life estimation related receiving data high sample rate determining loss life trend curve belonging power cable realistic estimations carried using trend adjusted exponential smoothing elsevier rights reserved
integrated bipolar operational amplifier amp type irradiated neutrons gamma rays radiation gain factors slew rate power supply current evaluated experimental results show decrease parameter values exposing radiation advantage increase voltage power supplies thermal annealing treatment damaged parameters also explored relationship among different frequency response parameters also studied leading analytical formula degraded parameters
integrated heat electricity dispatch crucial exploit synergistic benefits integrated energy systems however requires information electricity systems district heating systems dhss managed electricity control center ecc district heating control centers dhccs respectively reasons pertaining privacy communication dimension compatibility practical dhccs send detailed models ecc therefore new feasible region method proposed formulation new dhs models exploit flexibility dhss consideration building thermal inertia greedy method developed solve new modified feasible region models calculating series linear programming problems efficiently new models sent ecc used central dispatch considering dhs operation constraints integrated heat electricity dispatch modified models similar conventional power plants storages thus compatible current dispatch programs case studies verify effectiveness method although conservativeness exists total cost wind energy curtailment decreased compared conventional decoupled dispatch elsevier ltd rights reserved
intellectual humility usually regarded virtue paper conceptualized intellectual humility along two dimensions placing adequate level confidence one beliefs willing consider people beliefs tested whether children ages years adults perceived intellectual humility positive perceptions changed across development asked participants evaluate intellectually humble person compared intellectually arrogant person readily dismissed people beliefs intellectually diffident person unsure well supported belief young children favor intellectually humble person others older children adults liked person better tended consider nicer arrogant one smarter diffident one findings suggest virtuousness intellectual humility others recognized mid childhood
intelligence human source falsely thought true potentially harmful total lack addition collection veracity assessment gathered information one important phases process lie detection veracity assessment methods studied widely comprehensive analysis methods applicability lacking multi criteria analysis conducted compare scientifically valid lie detection veracity assessment methods terms accuracy ease use time requirements need special equipment unobtrusiveness results analysis showed studied features discourse nonverbal communication gained highest ranking assessed easiest fastest apply required temporal contextual sensitivity plausibility inner logic mace cbca also found useful limitations
interactive terrain visualization plays important role multiple networked applications like virtual worlds visualization multiplayer games distributed simulators since client server architecture obvious scalability limitations different peer peer schemes proposed trade solutions yield good robustness availability scalability kind systems paper propose new hybrid distributed architecture significantly improves scalability performance existing proposals proposed scheme redesigns relationships different elements hybrid architecture modifies information shared client neighboring peers varies messages exchanged among providing larger number users fluid navigation experience large virtual terrain
interactive narratives offer interesting opportunities study impact media behavior growing amount research games advocating social change including focusing interactive narratives highlighted potential attitudinal behavioral impact study examine relationship interactivity prosocial behavior well potential underlying processes yoked study design participants compared interactive noninteractive narrative structural equation modeling revealed significant differences prosocial behavior interactive noninteractive condition however support importance appreciation engagement narrative subsequent prosocial behavior observed summary results shed light processes underlying relationship noninteractive interactive narratives prosocial behavior also highlight interactivity multifaceted concept worth examining detail
interferon alpha ifn alpha first effective drug therapy hairy cell leukemia hcl nowadays used alternative treatment selected patients due unlimited treatment time monitoring early prediction response important moreover ifn alpha used therapy chronic hepatitis single nucleotide polymorphism interleukin gene ilb correlates therapy response role polymorphism therapy response ifn alpha treated patients hcl unknown thirty seven hcl patients treated included study treatment strategy response parameters blood cell counts soluble interleukin receptor silr bone marrow examination assessed relative decrease silr correlated outcome parameters response parameters ifn alpha treated patients correlated ilb polymorphism twenty one patients analyzed correlation silr ratio outcome months therapy ifn alpha cladribine cda median silr level showed relative decrease decreases significantly correlate time complete remission correlation analyses ilb genotype outcome parameters significant six patients diagnosed secondary malignancies one death registered median follow time years ifn alpha safe effective well tolerated long term treatment hcl relative decreases silr levels correlate time useful early predictor response significant correlation ilb polymorphism treatment response ifn alpha
interleukin well characterized growth factor hematopoietic cells also expressed cell types poorly described functions many studies provided evidence plays important role cell survival previously shown able increase glucose uptake hek cells suggesting factor requires sustained glucose metabolism promote cell survival study demonstrate contributes cell survival oxidative stress prominent feature pathophysiology cancer diabetes neurodegenerative diseases well aging process results suggest molecular mechanism involves signaling pathways mediated akt erk altogether findings show important role supporting viability non hematopoietic systems cell biochem wiley periodicals inc
intermittency wind energy pose great challenge power system operation control wind curtailment might necessary certain operating condition keep line flow within limit remedial action scheme ras offers quick control action mechanism keep reliability security power system operation high wind energy integration paper new ras developed maximize wind energy integration without compromising security reliability power system based specific utility requirements new distributed linear state estimation dlse also developed provide fast accurate input data proposed ras distributed computational architecture designed guarantee robustness cyber system support ras dlse implementation proposed ras dlse validated using modified ieee bus system simulation results demonstrate satisfactory performance dlse effectiveness ras
internal combustion engines applied energy converters passenger cars order increase efficiency energy integration techniques used recover waste heat adapted methodology required design organic rankine cycle orc waste heat recovery technology test influence external temperature efficiency idea cluster external temperature profile typical external temperature multi periods energy system design tested typical multi periods article methodology applied vehicle diesel engine order define energy integrated configuration vehicle estimate cost additional equipment performance indicators energy integration technology internal combustion engine done discussed according multi periods energy recovery potential single stage orc diesel engine assessed different temperature profiles orc equipment simultaneously pre sized cost estimated
internal combustion engines supercharged order enhance performances engine power proportional quantity fresh fluid introduced cylinder present general tendency try obtain actual specific powers high possible small possible cylinder capacity without increasing generated pollution hazards present paper investigates impact replacing centrifugal turbo compressor axial double rotor flux one proposed method allows number cylinders increase discharged airflow accompanied decrease fuel consumption using program developed mathcad environment present work aimed studying way temperature modifies end isentropic compression supercharging conditions taking account variation extreme limits ambient temperature influence upon evolution thermal load coefficient analyzed considering air pressure compressor cooling system outlet analysis completed exergetical study heat evacuated cylinder walls supercharged engine conditions conducted investigation allows verification whether significant differences observed axial dual rotor flux compressor centrifugal compressors
international estimates incidence non accidental burns nab children admitted burn centres vary hardly data dutch figures exist aim study evaluate incidence treatment outcome burns due suspected child abuse paediatric burns described process care outcome including accuracy sputovamo screening tool examined child burn treatment characteristics related suspicions child abuse neglect retrospective study conducted children aged years primary admission burn injuries burn centre rotterdam period data patient injury treatment characteristics collected using dutch burn repository addition medical records reviewed paediatric admissions suspected child abuse neglect present children screening questionnaires completed questionnaires completed sputovamo one positive signs significant independent predictors suspected child abuse burns genital area buttocks low socio economic status incidence suspected child abuse indicating generation additional support population comparable studies similar design countries elsevier ltd isbi rights reserved
internet banking one many services provided financial institutions become popular increasing trend due increased amount usage service internet banking become target adversaries one points risk attack login process therefore necessary security mechanism reduce risk research designs develops multi factor authentication protocol starting registration system generates authentication factors actual authentication mechanism factors categorised two groups short term long term authentication protocol three messages need exchanged client financial institution server many cryptographic processes incorporated protocol symmetric asymmetric cryptography symmetric key generation process method generating verifying digital signatures authentication messages proved analysed logic gny criteria owasp even though additional factors authentication users really feel extra load part shown satisfactory survey
internet gamblers problems gambling land based gamblers recent studies showed internet gamblers involved higher number gambling activities may confound relationship internet gambling gambling problems present study aimed test whether relationship internet gambling gambling problems persisted including variables related gambling involvement predictors namely time spent gambling diversity gambling formats data large sample french adolescents used associations disordered gambling money spent gambling internet gambling performed using generalized linear models controlling controlling diversity gambling formats time spent gambling results showed internet gamblers significantly problems land based gamblers relationship decreased diversity gambling formats time spent gambling controlled separately became non significant included model conclude time spent gambling diversity gambling formats rather internet gambling considered detrimental gambling behavior seemed capture different aspects gambling patterns study step forward changing conceptual model problem gambling gambling involvement main variable elsevier ltd rights reserved
internet gaming addiction iga becoming common widespread mental health concern although iga induces variety negative psychosocial consequences yet ambiguous whether brain addicted internet gaming considered pathological state investigated iga induced abnormalities brain specifically network perspective qualitatively assessed whether internet gaming addicted brain state similar pathological brain topological properties brain functional networks examined applying graph theoretical approach analyzing functional magnetic resonance imaging data acquired resting state iga adolescents age matched healthy controls compared functional distance based measures global local efficiency resting state brain functional networks two groups assess iga subjects brain topologically altered controls brain iga subjects severer impulsiveness brain functional networks showed higher global efficiency lower local efficiency relative controls topological differences suggest iga induced brain functional networks shift toward random topological architecture exhibited pathological states furthermore iga subjects topological alterations specifically attributable interregional connections incident frontal region degree impulsiveness associated topological alterations frontolimbic connections current findings lend support proposition internet gaming addicted brain could state similar pathological states terms topological characteristics brain functional networks
interoperability among heterogeneous software systems software quality sub characteristic methods dealing interoperability exhibit differences aspects like generality development method work products among others however authors understand interoperability non functional requirement general purpose practices identifying specifying requirement authors assess achieve interoperability using work products falling beyond defined practices consequently paper propose four best practices order accomplish interoperability among heterogeneous software systems best practices represented semat software engineering method theory kernel since includes language simple precise elements definition interoperability best practices enables unification effort focused software systems interoperability
interspecific aggression sibling species may enhance discrimination competitors recognition errors costly proximate mechanisms mediating increased discriminative ability unclear studied behavioral neural mechanisms underlying responses conspecific heterospecific vocalizations alston singing mouse scotinomys teguina species males sing repel rivals performed playback experiments using males allopatry sympatry dominant heterospecific scotinomys xerampelinus examined song evoked induction egr auditory system examine neural tuning modulates species specific responses heterospecific songs elicited stronger neural responses sympatry allopatry despite eliciting less singing sympatry results refute traditional neuroethological concept matched filter instead suggest expansion sensory sensitivity mediate competitor recognition sympatry
intrastriatal injection mesencephalic astrocyte derived neurotrophic factor manf protein shown provide neuroprotective neurorestorative effects hydroxydopamine ohda lesioned rat model parkinson disease used adeno associated virus serotype aav vector deliver human manf hmanf gene rat striatum days ohda lesion examine long term effects hmanf nigral dopaminergic neurons mechanisms underlying manf neuroprotection intrastriatal injection aav hmanf vectors led robust widespread expression hmanf gene injected striatum weeks increased levels hmanf protein also detected ipsilateral substantia nigra hmanf gene transfer promoted survival nigral dopaminergic neurons regeneration striatal dopaminergic fibers upregulation striatal dopamine levels resulting long term improvement rotational behavior weeks viral injections using syy cells found intra extracellular application manf protected cells ohda induced toxicity via inhibiting endoplasmic reticulum stress activating pik akt mtor pathway results suggest aav mediated hmanfgene delivery striatum exerts long term neuroprotective neuroregenerative effects nigrostriatal dopaminergic system parkinsonian rats provide insights mechanisms responsible manf neuroprotection elsevier inc rights reserved
intrauterine devices iud common method reversible birth control used worldwide adolescents infrequently uterine perforation caused iud hampering diagnosis treatment herein report case uterine perforation year old primipara insertion iud possessed memory function aimu mcu patient presented vomiting abdominal pain insertion aimu mcu iud treated via laparoscopy full recovery present case indicated uterine perforation caused aimu mcu iud may occur rare complication uterine perforation occur adolescent clinicians might consider diagnosis uterine perforation adolescent reporting vomiting abdominal pain iud insertion laparoscopy could reasonable treatment option patients
introduced basic principle synchronous rectification low voltage high current fields using digital control feature switch power design scheme digital buck converter put forward analyzed device choice designed circuit converter designed made prototype experiment data given including driving waveform efficiency curve one cycle control strategy made extend using fields prototype designed intelligence communication interface means experiment power supply fast dynamic response high precision efficiency reach
introducing time flight image sensors actual engineering applications pattern recognition constrained limited depth lateral resolution also similar precision depth measurement throughout whole pixel matrix real operating environment observed scene hardly exhibits homogeneous reflectance factor moreover light beam laser source presents nonuniform optical power distribution space thus amount incident light sensor surface varies drastically one pixel another signal noise ratio address problem paper investigates impact scene light source non ideal characteristics sensor performance adaptive pixel analog signal processing technique also presented applied design complementary metal oxide semiconductor cmos range camera featuring interesting cost efficient solution
introduction severe form parkinson disease kufor rakeb syndrome mutations atpa park gene lead early juvenile onset parkinsonism often accompanied dementia atpa encodes lysosomal type atpase ortholog caenorhabditis elegans catp gene phenotypes mutations alleles show high mortality low reproduction objectives since difficult study humans wanted investigate potential use elegans model kufor rakeb syndrome difficult obtain enough catp mutant worms standard nmr metabolic profiling explored focused ultrasonication extraction miniaturized nmr techniques overcome limitation methods one two dimensional nmr experiments jres tocsy performed commercial high resolution magic angle spinning mas probe sample volume significant features identified analysis variance anova volcano plots pca pls results assignment statistically relevant peaks resulted identification twenty altered metabolites previous studies catp mutants identified strong morphological functional changes mitochondria findings altered tca metabolites fumarate succinate branched chain amino acids leucine isoleucine valine nucleotides amp atp gtp formate hypoxanthine appear support findings highest fold changes wildtype relative catp strains found gtp formic acid known inhibit mitochondrial respiratory chain complex high hypoxanthine catp indicates increased nucleotide salvage pathway alterations remaining metabolites may result recently discovered activation ampk amp activated protein kinase inhibition mtor mechanistic target rapamycin pathways together catabolic response recover energy production conclusions effect catp mutation elegans level metabolites correlated metabolic dysfunction human park ortholog may possible uncover molecular mechanism behind parkinsonism kufor rakeb syndrome
introduction data epidemiology hepatitis among individuals use drugs low threshold settings lacking although crucial assess burden disease aid design treatment strategies objective aim study characterize epidemiology disease related hepatitis population attending low threshold methadone program materials methods cross sectional study population attending mobile low threshold methadone program lisbon portugal carried survey included assessment risk factors infection hepatitis virus hcv liver disease hcv serology rna detection hcv genotyping liver disease staging results total participants enrolled men mean age years injecting drug use idu reported among people inject drugs excessive drinking hiv coinfection reported respectively among participants active infection followed hospital consultation overall seroprevalence hcv idu non idu people inject drugs excessive drinkers among seropositives hcv active infection present among individuals active infection common genotypes whereas severe liver fibrosis cirrhosis age years older hcv genotype coinfection hiv significant predictors cirrhosis conclusion population high burden hepatitis several characteristics favor dissemination infection healthcare strategies urgently needed address hepatitis setting copyright wolters kluwer health inc rights reserved
introduction factors associated lower health related quality life hrqol among older african american breast cancer survivors bcs elucidated methods using surveillance epidemiology end results medicare health outcome survey linked dataset resected bcs identified using recent survey diagnosis individuals physical pcs mental mcs component score points lower median categorized poor hrqol univariate multivariate analyses identified predictors poor hrqol results bcs median age median time diagnosis survey months median follow months median pcs iqr reporting poor pcs median mcs iqr reporting poor mcs predictors poor pcs included advanced age larger tumor size comorbidities inability perform activities daily living adls modified radical mastectomy infiltrating lobular carcinoma stage iii disease inability perform adls adls independent predictor poor pcs mcs conclusion elderly bcs poor hrqol associated socioeconomic status tumor specific factors rather impairment adls condensed abstract physical mental hrqol african american breast cancer survivors dependent socioeconomic tumor related characteristics rather inability perform adls
introduction national osteoporosis guideline group nogg produced guideline prevention treatment osteoporosis update paper presents major update guideline scope review assessment management osteoporosis prevention fragility fractures postmenopausal women men age years methods available systematic reviews meta analyses randomised controlled trials used provide evidence base conclusions recommendations systematically graded according strength available evidence results review evidence recommendations provided diagnosis osteoporosis fracture risk assessment lifestyle measures pharmacological interventions duration monitoring bisphosphonate therapy glucocorticoid induced osteoporosis osteoporosis men postfracture care intervention thresholds conclusion guideline received accreditation national institute health care excellence nice provides comprehensive overview assessment management osteoporosis healthcare professionals involved management
introduction overactive bladder oab symptoms urge frequency nocturia generally considered surgically curable learning institutions integral theory hypothesizes oab prematurely activated normal micturition reflex caused loose suspensory ligaments potentially curable surgically repairing ligaments test hypothesis surgical repair loose cardinal uterosacral ligaments patients degree greater uterine apical prolapse material methods multicenter prospective case control audit females mean age inclusions symptomatic apical prolapse greater degree popq stages least two pelvic symptoms exclusions comorbid medical problems known cause chronic pelvic pain infection sphincter tears neurological bladder conditions surgery minimally invasive cardinal uterosacral ligament repair using tfs tissue fixation system primary outcome uterine prolapse cure secondary outcomes bladder bowel pain symptoms improvement results prolapse cure patients symptom incidence cure months brackets urge incontinence frequency nocturia chronic pelvic pain cpp fecal incontinence statistics mcnemar tests test significant changes symptoms incidence frequency baseline preoperative postoperative phase symptom null hypothesis baseline months surgery versus baseline equal months surgery tested indicating prevalence incidence rate conclusions bladder bowel incontinence chronic pelvic pain occur predictable groupings associated apical prolapse oab symptom improvement tfs ligament repair provides good alternative anticholinergics especially considering association dementia causation application integral theory system potential significantly improve clinical practice qol ageing women delaying entry nursing homes creating new scientific research directions take home message symptoms chronic pelvic pain bladder bowel dysfunction occur relatively predictable groups caused lax suspensory ligaments cured improved tfs mini sling ligament repair
introduction rotational acetabular osteotomy rao joint conserving surgery femoral head coverage autologous cartilage improved achieve joint stability one common joint conserving surgeries acetabular dysplasia hip adult patients favorable outcome rao pre initial coxarthrosis reported middle long term observation however surgery selected advanced coxarthrosis objective study investigate long term clinical outcomes radiological arthritis changes patients treated rao could followed years longer investigate joint conservation rate preoperative arthritis stage patients methods subjects patients joints treated rotational acetabular osteotomy alone january june patients joints retrospectively investigated mean age time surgery years years mean duration follow years months years months results significant differences harris hip score among three groups surgery however score significantly lower advanced pre initial coxarthrosis cases final follow joint conservation rate end point defined time total hip arthroplasty years surgery stage joint conservation rates pre initial advanced coxarthrosis cases respectively demonstrating significantly lower rate advanced coxarthrosis cases mean time conversion years pre initial advanced coxarthrosis cases respectively conclusion outcome rotational acetabular osteotomy hips pre initial coxarthrosis satisfactory rotational acetabular osteotomy effective surgery treating symptomatic developmental dysplasia hip selected patients
introduction aim study evaluate clinical radiographic short term results complications surgical hip dislocation young patients years materials methods clinical radiographic outcomes assessed patients underwent surgical hip dislocation ganz type approach diagnosis included legg calve perthes disease slipped capital femoral epiphysis femoroacetabular impingement osteonecrosis femoral head multiple hereditary exostoses pigmented villonodular synovitis clinical data modified harris hip score nonarthritic hip score item short form health survey stulberg classification morphometric indexes signs osteonecrosis osteoarthrosis used evaluation results mean years follow range years hips patients evaluated common diagnoses legg calve perthes disease slipped capital femoral epiphysis femoroacetabular impingement multiple hereditary exostoses mean age surgery years range years approach femoral head neck osteoplasty dunn type osteotomy labrum refixation synovectomy femoral head mosaicplasty open reduction fixation slipped capital femoral epiphysis performed finally association pelvic intertrochanteric osteotomy follow better outcome scores obtained progression osteonecrosis femoral head observed four cases three patients required implant total hip prosthesis conclusions years follow results comparable previous studies patients high rate satisfaction however effectiveness procedures proved long term results complications seem related preoperative lesion type treatment
introduction evidence anatomically correct anterior cruciate ligament reconstruction aclr offers lower rate degenerative changes development would lead better outcome significance understanding abnormal anterior tibial translation att aclr patients yet established methods sixty subjects patients years aclr healthy controls underwent mri quantitative cartilage mapping morphological whole organ magnetic resonance imaging score worms evaluation performed self reported questionnaires used subjective clinical evaluation correlations calculated following mri measurements femoral tunnel inclination acl graft inclination lateral medial compartment att results aclr group positive correlation found patellar cartilage values sagittal acl graft inclination aclr group lateral compartment att showed negative correlation acl graft inclination subjective clinical evaluation positive correlation morphological degenerative changes femoral tunnel showed positive correlation acl graft inclination plane conclusions increased att offers worse clinical outcome increased rate degenerative changes furthermore att affected acl inclination inclination drilling tunnel affects acl graft inclination thereby independent drilling techniques provide superior results anatomical acl graft positioning
introduction treat target guidelines recommend achieving remission low disease activity rheumatoid arthritis however reduction adverse events costs associated lower disease activity unclear methods used corrona linked medicare data identify patients time varying disease activity measured using clinical disease activity index cdai outcomes included cause hospitalization composite hospitalization emergency department visits mortality medical costs outcome specific cox proportional models evaluated adjusted hazard ratios disease activity outcomes controlling potential confounders including comorbidities grouped four patient phenotypes costs analyzed mixed models using gaussian distribution log transformation results depending outcome patients contributed person years median age years women baseline approximately patients remission low disease activity dose response relationship disease activity remission low moderate high incidence hospitalizations per respectively adjusted hazard ratios significant remission low high compared moderate disease activity similar trends observed visits mortality crude difference annual medical costs remission moderate disease activity adjusted difference conclusion leveraging benefits linking registry administrative data together lower disease activity associated incrementally reduced risks cause hospitalization visits mortality medical costs dose dependent fashion copyright john wiley sons ltd
introduction present demographic differences across gastro oesophageal reflux disease gord spectrum district general hospital patients methods data prospectively collected years endoscopy patients categorized erosive oesophagitis barrett oesophagus nonerosive reflux disease ner analysis comparison ner database gord without closed analysis demographic differences oesophageal adenocarcinoma oac total population diagnosed results gord sex male predominance ner male female ratios respectively mean age presentation years years ner years women older men years respectively prevalent oac male female ratio incident oac male female ratio among men developed oac within sex proportion oac higher among men oac diagnosis women slightly significantly older years conclusion two views may explain findings first women either milder reflux reduced mucosal sensitivity hence reflux remains silent longer alternatively women genuinely develop reflux later protected longer developing gord complications early evidence emerging female sex hormones may indeed protective role gord reproductive period suggest reflux consequences may example protection conferred eve copyright wolters kluwer health inc rights reserved
introduction worldwide transport sector faces several issues related rising traffic demand congestion energy consumption noise pollution safety etc trying stem problem european commission encouraging modal shift towards railway considered one key factors development sustainable european transport system coveted increase railway share transport demand next decades attempt open rail market freight international recently also local services strengthen attention capacity usage system contribution proposes synthetic methodology capacity utilisation analysis complex interconnected rail networks procedure dual scope since allows theoretically robust examination suburban rail systems solid approach applied additional consistent assumptions feasibility strategic analysis wide networks efficiently exploiting use big data available open databases method particular approach proposes schematization typical elements rail network stations line segments applied case lack detailed data authors opinion strength points presented procedure stem flexibility applied synthetic methods joint analysis nodes lines article building quasiautomatic model carry several analyses changing border conditions assumptions even presents general abacuses showing variability capacity utilization network elements function basic parameters results helped presented case studies one focuses detailed analysis naples suburban node tries broaden horizon examining whole european rail network specific zoom belgium area first application shows procedure applied case availability fine grained data metropolitan regional analysis allowing precise detection possible bottlenecks system individuation possible interventions relieve high usage rate elements second application represents going attempt provide broad analysis capacity related parameters entire european railway system explores potentiality approach possible exploitation different open big data sources outcomes underline necessity rely proper adequate information accuracy results significantly depend design precision input database conclusion conclusion proposed methodology aims evaluate capacity utilisation rates rail systems different geographical scales according data availability outcomes might provide valuable information allow efficient exploitation deployment railway infrastructure better supporting policy investment prioritization rail infrastructure access charges helping minimize costs users presented case studies show method allows indicative evaluations use system comparative analysis different elementary components providing first identification weak links nodes specific detailed analyses carried taking account depth actual configuration technical characteristics real composition traffic elements influencing rail capacity adopted operating systems station traffic route control safety system elastic release routes overlap block sections etc
introduction mondor disease rare superficial thrombophlebitis historically involving thoracic venous system women however occur gender skin case report report year old man type one diabetes presented thrombosis superficial dorsal vein penis treated fungal infection treatment non steroidal anti inflammatory drugs low molecular weight heparin contributed favorable outcome weeks conclusion pathogenesis treatment mondor disease remain incompletely dominated predisposing factors highlighted literature might interesting add diabetes due frequent pelvic problems leading potential venous inflammatory trigger societe nationale francaise medecine interne snfmi published elsevier masson sas rights reserved
introduction behavioral changes often occur moderate severe traumatic brain injury tbi lead poor health psychosocial functioning quality life challenges evaluating behaviors often result complexity variability way conceptualized defined propose test conceptual model specific behavioral symptoms tbi serve basis better assessment treatment hypothesized clusters individuals unique emotional cognitive behavioral characteristics would emerge would illustrate conceptual model methods conducted model based cluster analyses two cohorts months post injury months post injury adults moderate severe tbi explore face validity conceptual model evaluating participants clustered regard emotional patient health questionnaire positive negative affect schedule cognitive neuropsychological test battery frontal behavioral frontal systems behavior scale symptoms results cohort unique clusters participants emerged differed significantly regard emotional state cognition behavior psmonths demonstrated complex pattern symptoms severe behavioral symptoms occurred context severe emotional symptoms even absence cognitive impairment however problematic behavioral symptoms also present context severe cognitive impairment even absence emotional symptoms conclusions emotional cognitive behavioral characteristics represented expected based proposed conceptual model behavior conceptual model provides basis evaluating behavioral changes moderate severe tbi identifying modifiable targets relevant subpopulations behavioral intervention goal improved evidence based personalized medicine population
introduction lumber punctures common procedure patients cancer however potential complication lumbar puncture postdural puncture headache risk neoplastic seeding central nervous system led concern performing epidural blood patches ebps treatment postdural puncture headaches patients cancer goal retrospective study evaluate cancer seeding central nervous system patients diagnosed leukemia lymphoma methods institutional electronic records queried year period patients leukemia lymphoma received least one ebp demographic procedural data cancer treatments mortality examined patient records reviewed evidence new onset neoplastic central nervous system seeding epidural blood patch results total patients identified review eighteen patients diagnosis leukemia lymphoma following ebp none patients experienced new cancer cancer seeding central nervous system following epidural blood patch median follow years discussion though risks ebp cancer patient population hypothesized previous studies assessed risk seeding cancer central nervous system based results epidural blood patch bears low risk cancer seeding used treat postdural puncture headache unresponsive conservative treatments
introduction optogenetic experimental technique combines genetic engineering optical physics procedures mark specific neurons brain activate rays light certain frequency aim explain readers versed genetics history rationale present future applications optogenetic brain mental processes research development current development technique allowing considerable advances accurate knowledge neural circuits control behavior motivational cognitive states like hunger thirst pain sleep learning memory among first shocking results creation control false memories conclusions optogenetics revolutionary experimental technique called replace classics techniques brain behavior research important way development control mental processes treatment diseases
introduction patient behavioral psychological factors key determinants medical treatment adherence representing research management challenge purpose highlighting implication behavioral psychological factors associated patients compliance medical treatment therapeutic success relation acute coronary syndrome methods monitored seventeen patients hospitalized acute coronary syndrome using qualitative observational analysis divided two groups group patients patients segment elevation myocardial infarction stemi group patients angina pectoris non segment elevation myocardial infarction nstemi patients monitored one month terms clinical biological indicators echocardiography according current guidelines psychological assessment used self rated questionnaire health related behavioral health perception scale depression scale hads health locus control scale results identified higher degree receptivity responsibility adopting health promoting behaviors patients less severe cardiac pathology angina pectoris mild moderate systolic dysfunction patients came regularly one month noticed high scores regarding information knowledge profile three levels clarity information current clinical state specific medical treatment recommended healthy behaviors groups groups patients exhibited high degree receptivity responsibility adopting health promoting behavior regards stress management check visits attendance depth analysis revealed patients confidence therapy stress management check visits attendance significantly correlated overall level knowledge additionally self perception projected health present overall satisfaction future overall satisfaction significantly correlated information knowledge profile conclusions medium long term management ischemic cardiac disease psychological behavioral factors relevant players part patients assessment algorithm order improve adoption healthy behaviors treatment adherence
introduction perception direct gaze another individual gaze directed observer leads eye contact known influence wide range cognitive processes behaviors stress effects mainly reflect positive impacts human cognition may thus used relevant tools therapeutic purposes objectives review aim provide exhaustive review eye contact effects discussing limits dominant models used explain effects illustrate therapeutic potential eye contact targeting pathologies show preserved gaze processing deficits one several functions targeted eye contact effects propose concrete ways eye contact could employed therapeutic tool discussion regroup variety eye contact effects four categories including memory effects activation prosocial behavior positive appraisals self others enhancement self awareness emphasize models proposed account effects poor predictive value descriptions effects needed emphasize people pathologies affect memory social behavior self appraisal self awareness could benefit eye contact effects focus depression autism alzheimer disease illustrate proposal knowledge anomaly eye contact reported depression patients suffering alzheimer disease early moderate stage shown maintain normal amount eye contact interlocutor take account autism controversial regarding whether gaze processing preserved altered first view individuals thought elude omit gazing another eyes second individuals considered able process gaze others adopt first stance following view people autism interested processing social signals gaze could efficiently properly motivated pathology emphasize eye contact could used example enhance sensitivity bodily states thus improving emotional decision making autism lead positive appraisal self others depression improve memory performances alzheimer disease generally motivate recipient engage therapeutic process finally propose two concrete ways employ eye contact effects therapeutic tool first develop cognitive behavioral tools learn motivate recipient create frequent prolonged eye contact periods second raise awareness among caregivers beneficial effects eye contact teach way use eye contact reach optimum effects future investigations however needed explore ways eye contact effects efficiently integrated therapeutic strategies well identify clinical populations benefit therapeutic interventions encephale paris
introduction debate ability patients alzheimer disease build date representation memory function termed mnemonic anosognosia form anosognosia typified accurate online evaluations performance dysfunctional outmoded representations function generally method tested whether people alzheimer disease could adapt change representations memory performance across three different six week memory training programs using global judgements learning results showed whereas online assessments performance accurate patients continued make inaccurate overestimations memory performance despite fact magnitude predictions shifted according memory training level patients showed ability change retain representation performance time dysfunctional one first time literature able use analysis using correlations support claim based large heterogeneous sample patients alzheimer disease conclusion results point failure retain online metamemory information rather information never used incorporated longer term representations supporting refining mnemonic anosognosia hypothesis
introduction tryptase histamine levels may serve indicator mast cells stimulation related various diseases mastocytosis ige related allergy confirming participation pathogenesis aim analyse tryptase histamine levels assess correlation tryptase histamine levels serum different groups study patients material methods determinations performed mastocytotic patients including patients systemic mastocytosis urticaria pigmentosa innate angio motor oedema due inhibitor deficiency healthy controls tryptase levels determined using phadiaunicap tryptase reagents histamine concentrations measured using histamine elisa kit labordiagnostikanord results patients systemic mastocytosis level tryptase high majority patients urticaria pigmentosa level tryptase elevated exceed half patients systemic urticaria level histamine elevated correlated increased level tryptase people hereditary angioedema due inhibitor deficiency serum levels tryptase histamine normal group correlation shown occur levels study parameters conclusions correlation found tryptase histamine levels thus seems reasonable conclude mediators released mast cells independently
introduction women suffer depression frequently men indicates sex hormones might involved etiology disease aims purpose study assess relationship testosterone depression pathophysiology depressive women along sexual function also investigated whether antidepressant treatment causes change levels hormone sexual function methods premenopausal female patients aged years diagnosed major depression included study patient group year old premenopausal women without depression included control group main outcome measures serum testosterone sex hormone binding globulin shbg levels measured twice antidepressant treatment bioavailable testosterone cbt levels calculated using assay results total testosterone shbg albumin according formulas vermeulen depression severity measured using item hamilton depression rating scale sexual function evaluated arizona sexual experience scale results mean cbt levels significantly increased patient group antidepressant treatment pre treatment cbt levels significantly lower patient group control group significant differences among groups terms shbg level conclusion low testosterone levels depressed women compared women control group elevated levels post pharmacotherapy suggest testosterone may involved depression
introduction purpose relative age effect rae described consequence differences ages individuals within age group youth sports relatively older children may physical developmental advantage younger children purpose study determine relationship relative age sports injury cohort pediatric athletes methods probability sample children age sports injuries extracted regional hospital database relative age defined child birth month relative month activity uses arbitrary age cutoff main outcome measure activity specific birth month ratio developed compared birth month data state linear regression models used determine overrepresentation underrepresentation sports injuries prepubescent pubescent groups separately results among prepubescent patients linear regression model indicated significant rae sports injury born right cutoff month sports underrepresented study cohort relative representation general population pubescent group rae reversed born closest age cutoff date sports least represented relative general population conclusions results demonstrate rae youth sports injury risk cohort pediatric athletes sports related injuries findings may used inform safe practices within sports participation among youth athletes
introduction single institution case control study conducted evaluate risk developing chronic myeloproliferative neoplasms mpns associated prior autoimmune disease cardiovascular disease cvd method cases mpn patients controls chronic lymphocytic leukemia cll patients odds ratios ors values using fischer exact tests calculated data adjusted confounding effects logistic regression results significantly increased risk mpns compared cll observed subjects prior history autoimmune disease positive association jak positive mpn autoimmune disease observed follow significantly increased risk mpn compared cll also observed subjects prior thromboembolic events events mpn group increased risk jak positive disease observed subjects prior events discussion discussed chronic inflammation relation autoimmunity atherosclerosis might elicit mutations hematopoietic stem cell resulting mpns whether association actually reflects long lasting pre mpn diagnosis phase mpn disease per contributes chronic inflammatory state immune deregulation elsevier ltd rights reserved
introduction acid nucleic aptamers rna dna oligonucleotides capable binding target molecule high affinity selectivity molecules promising tools nuclear medicine many aptamers used targeting molecule radiopharmaceuticals preclinical studies beta glucans main structural cell wall components fungi bacteria present study two radiolabeled beta glucan aptamers seq seq evaluated identity infectious foci caused fungal bacterial cells methods aptamer labeling mtc performed direct method biodistribution studies accomplished swiss mice infected right thigh muscle staphylococcus aureus candida albicans mtc radiolabeled library consisting oligonucleotides random sequences used control results higher uptake radiolabeled aptamers infected thigh left thigh muscle non infected aureus infected animals target non target ratios seq seq ratios statistically higher value found radiolabeled library control regard biodistribution statistical difference verified aptamers control uptakes infection foci albicans infected animals target non target ratios radiolabeled library seq seq respectively scintigraphic imaging infected foci using radiolabeled aptamers possible aureus infected mice conclusions seq seq aptamers proved inefficient diagnosis albicans infection nevertheless applicability diagnosis aureus bacterial infections scintigraphy explored elsevier inc rights reserved
introduction association usual interstitial pneumonia uip carcinogenesis well established however detailed analyses investigated clinicopathological immunohistochemical genetic features patients primary lung adenocarcinoma adc uip uip adc methods identified patients adc setting uip uip adc group patients primary adc compared clinicopathological immunohistochemical genetic features uip adc group patients adc without uip iion uip adc group results clinicopathological features uip adc included older age occurrence male predominance smoking history predilection lower lobe large tumor size high incidence lymph vessel invasion pleural invasion lymph node metastasis poor survival rate however cause death patients uip adc largely influenced respiratory complications histologically patients uip adc group could stratified according invasive mucinous predominant subtype genetically patients uip adc group lower egfr higher kras mutation rates compared patients non uip adc group conclusions uip adc associated poor prognosis owing high frequency perioperative complications rather malignancy tumor high prevalence invasive mucinouspredominant subtype cases uip adc uip adc also low prevalence egfr mutations high prevalence kras mutations findings suggest uipadc distinct non uip adc international association study lung cancer published elsevier inc rights reserved
introduction angina pectoris prevalent symptomatic manifestation ischemic heart disease frequently leads poor quality life major cause medical resource consumption since early descriptions nitrite nitrate century considerable advancement pharmacologic management angina areas covered management chronic angina often challenging clinicians despite introduction several pharmacological agents last decades significant proportion patients continue experience symptoms refractory angina subsequent disability purpose review searched pubmed cochrane databases inception august clinically relevant publications guide current practice angina therapy development article briefly review pathophysiology angina mechanism based classification current therapy followed evidence based insight traditional novel pharmacotherapeutic agents highlighting clinical usefulness expert opinion considering wide array available therapies different mechanism efficacy limiting factors personalized approach essential particularly patients refractory angina ongoing research novel pharmacologic modalities likely provide new options management angina
introduction approximately patients hemophilia received nonheated coagulation factor concentrates early infected hepatitis virus hcv approximately infected hiv aim evaluated efficacy safety administering ledipasvir ldv sofosbuvir sof japanese patients hemophilia methods forty three patients hemophilia genotype hcv treated ldv sof weeks efficacy safety results laboratory tests evaluated results twenty patients coinfected hiv hcv sustained virological response svr weeks therapy hiv positive patients hiv negative patients efficacy ldv sof significantly different hiv positive hiv negative patients however rate svr weeks therapy patients cirrhosis significantly lower patients without cirrhosis overall patients adverse events severity mild moderate serious including death hiv positive group patients completed treatment alterations antiretroviral regimen significant abnormalities renal function detected patients taking antiretroviral regimen tenofovir disoproxil fumarate conclusions cohort study ldv sof effective safe svr patients cirrhosis lower noncirrhosis group thus patients hemophilia genotype hcv treated early possible onset cirrhosis
introduction asthma control includes control symptoms future risk sought evaluate usefulness degree spirometric reversibility forced expiratory volume one second fev target parameter control methodology patients bronchial asthma followed one year clinical functional inflammatory control parameters asthma collected area curve auc estimated establish cutoff point post bronchodilator fev reversibility relation noncontrol asthma univariate analysis differences groups studied based degree estimated reversibility factors significance sensitivity specificity positive predictive value auc increased use relief medication observed along significantly progressive drop post bronchodilator fev post bronchodilator fev fvc forced expiratory volume one second forced vital capacity conclusions spirometric reversibility useful assessing control asthmatic patients predict future risk parameters cutoff point related non control asthma found work elsevier ltd rights reserved
introduction atopic dermatitis common inflammatory skin disease increasing prevalence treatment patients suffering mild moderate disease includes use emollients topical glucocorticoids topical calcineurin inhibitors patients chronic severe atopic dermatitis topical therapy usually insufficient require use systemic immunosuppressive drugs often limited due toxicity severe adverse effects areas covered review summarizes literature mechanism action clinical efficacy safety dupilumab monoclonal antibody targets subunit interleukin receptor leading inhibition pathways literature search performed pubmed clinicaltrials gov using key words dupilumab regn atopic dermatitis expert commentary dupilumab offers innovative therapeutic approach moderate severe atopic dermatitis approved clinical use country yet however due excellent clinical efficacy favorable safety profile dupilumab may revolutionize treatment moderate severe atopic dermatitis next upcoming years
introduction attention deficit hyperactivity disorder adhd one prevalent neuropsychiatric disorders childhood adolescence stimulants usually first choice drug however many patients respond stimulants may also worsen comorbid sleep mood anxiety disorders associated problems misuse diversion bupropion dopamine norepinephrine reuptake inhibitor promising nonstimulant alternative reports positive outcomes adhd management adolescent adult populations study systematically reviews clinical trials subject methods using keywords bupropion wellbutrin zyban elontril attention deficit hyperactivity disorder adhd addh preliminary search pubmed ovid databases yielded articles published english january may six articles clinical trials involving children full articles also reviewed references interest results available open controlled randomized trials demonstrated bupropion efficacy improving adhd symptoms three head head trials found bupropion efficacy comparable methylphenidate however large double blind placebo controlled multicenter study bupropion found smaller effect sizes bupropion quantified using teacher parent ratings adhd symptoms methylphenidate terms tolerability head tohead trial found headache observed frequently methylphenidate treated group bupropiontreated group whereas frequency side effects differ significantly conclusion current findings interpreted caution limited database bupropion considered pharmacological management childhood adolescentadhd randomized controlled trials larger sample sizes warranted also evidence benefits children comorbid adhd conduct substance use depressive disorders
introduction autologous hematopoietic stem cells gaining ground effective safe treatment treating severe refractory crohn disease autologous hematopoietic stem cell therapy ahsct induces resetting immune system novo regeneration cell repertoire repopulation epithelial cells bone marrow derived cells help patients achieve clinical endoscopic remission areas covered herein authors discuss use ahsct treating patients improvements disease activity seen patients severe autoimmune disease patients severe underwent ahsct concomitant malignant hematological disease clinical endoscopic remission achieved patients treated ahsct randomized trial published date astic trial support use ahsct treat yet critics trial deemed ahsct promising treatment severe refractory expert opinion even promising evidence presented hsct refractory protocols need refined collaboration hemato oncology professionals goal incorporate safe ahsct restore tolerance delivering effective immune cease fire treatment option severe refractory
introduction autonomic neuropathy found strong predictor sudden cardiac death reported variably patients rheumatoid arthritis manifesting sweating disturbances gastrointestinal irregularities bladder erectile dysfunction significantly affect patient quality life alter course disease aim study undertaken find prevalence severity patients attending rheumatology clinic tertiary care hospital new delhi india also investigate correlation patient disease factors age gender disease severity duration serological status materials methods cross sectional study assessed subjectively survey autonomic symptoms cardiac autonomic involvement assessed five cardiovascular reflex tests described ewing heart rate response deep breathing standing valsalva blood pressure response standing sustained handgrip results total patients age sex matched healthy volunteers recruited upon analysis found prevalence cardiac significantly higher patients compared controls positive correlation disease severity observed patient reported questionnaire objective cardiovascular reflex tests significant correlation grade patient age gender disease duration serological status established conclusion end study concluded pathological mechanisms responsible autonomic dysfunction active compared others
introduction bipolar disorder chronic disabling condition characterized alternating manic depressive episodes bipolar disorder associated functional impairment poor quality life morbidity mortality despite significant clinical social economic burden treatment options bipolar disorder still limited several clinical trials shown efficacy atypical antipsychotic quetiapine qtp treatment condition however mechanisms underlying antidepressant anti manic effects qtp remain poorly understood areas covered article provides emerging evidence pre clinical studies regarding antidepressant anti manic mechanisms action qtp combination primary active metabolite norquetiapine qtp modulates several neurotransmitter systems including serotonin dopamine noradrenaline histamine qtp also seems influence mediators immune system expert opinion pre clinical studies provided valuable information potential antidepressant mechanisms action qtp pre clinical studies qtp anti manic effects still scarce major problem refers lack valid experimental models bipolar disorder additionally immune genetic based studies largely descriptive role qtp metabolite norquetiapine modulating non neurotransmitter systems also needs addressed
introduction boron containing compounds bccs attractive chemical entities drug development compounds used treatment human disease studies pharmacodynamics suggest employ multiple forms activity however less known pharmacokinetic profile molecules areas covered herein compiled reported data presented accordance classical adme system identifying scope bccs respective fields analysis suggests compounds several distinct ways move within human body specific structural features molecule account distinct pharmacokinetic profile insights useful designing bccs desired effect expert opinion increasing knowledge pharmacokinetics bccs providing broader understanding design new release systems potential drugs well probable protein transporters could related key roles physiological processes transporters may involved sodium transport hormone release regulation cell cycle shared features among groups bccs identified order apply insights design advantageous compounds
introduction brain derived neurotrophic factor bdnf disturbances life stress independently interaction hypothesized induce chronic pain examined whether bdnf pathway val met genotype gene expression serum levels early recent life stress interaction associated presence severity chronic multi site musculoskeletal pain methods cross sectional data subjects netherlands study depression anxiety presence severity chronic multi site musculoskeletal pain determined using chronic pain grade cpg questionnaire bdnf val met polymorphism bdnf gene expression bdnf serum levels measured early life stress age assessed calculating childhood trauma index using childhood trauma interview recent life stress assessed number recent adverse life events using list threatening events questionnaire results compared val val bdnf met carriers often chronic pain whereas differences found bdnf gene expression serum levels higher levels early recent stress associated presence severity chronic pain interaction effect found bdnf pathway life stress associations chronic pain presence severity conclusions study suggests bdnf gene marks vulnerability chronic pain although life stress alter impact bdnf chronic pain seems independent factor onset persistence chronic pain
introduction breastfeeding difficulty ankyloglossia affect mother baby breastfeeding dyad renewed emphasis today culture breast milk mothers may feel increasing pressure breastfeed inability may cause significant distress recently online parenting forums seen exponential growth forums allow mothers connect peers undergoing similar life transitions purpose study review online discussions regarding ankyloglossia understand mothers experiences breastfeeding materials methods performed ethnographic content analysis online threads posts regarding ankyloglossia based six domains initial expectations breastfeeding complications questions diagnosis treatment outcomes results one fourth women participated online forum discussions initial expectations breastfeed however many found impossible due poor latch pain concerns frequently exacerbated healthcare providers reportedly missed overlooked ankyloglossia although complications made breastfeeding challenging experience mothers often described subjective physical improvements frenotomy conclusion breastfeeding difficulty commonly voiced concern online ankyloglossia forums forum analysis effective way gain insight patients experiences allows providers anticipate concerns provides effective counseling
introduction burn wound infection bwi primarily caused aerobic bacteria followed fungi anaerobes viruses worldwide decrease incidence bacterial infections burns due better patient care availability effective antibiotics consequently fungal burn wound infection shown increasing trend aim aim study assess frequency fungal infections thermal burn wounds respect age wounds total body surface involved depth burns assess common fungal pathogens materials methods study conducted patients admitted thermal burn wounds burns surgical unit pus swab scrapings taken local anaesthesia burn patient scrapings put sterile container sent mycology section microbiology department examined direct microscopy culture studies sabouraud dextrose agar medium mycology section microbiology department results study incidence fungal infection burn wound patients came incidence fungal infection increased increase total body surface area tbsa increase depth age burn study maximum positive fungal cultures seen third week post burn period positive culture seen first week positive fugal cultures seen second postburn week candida albicans found common organism followed non albicans candida aspergillus conclusion concluded study incidence fungal infections thermal burns increased increase post burn period increasing depth tbsa burns candida albicans found common fungus
introduction inhibitor inh serine protease inhibitor plasma plays central role cross talk among complement coagulation fibrinolytic kallikrein kinin systems however previous reports indicate thrombotic risks children following supraphysiological dosing inh objective investigate role supraphysiological inh concentrations clot development without addition escherichia coli coli fresh human whole blood using thromboelastometry materials methods blood collected citrate tubes inh human serum albumin hsa added control activated partial thromboplastin time aptt analysed plasma analyses non activated thromboelastometry natem extrinsic extem intrinsic thromboelastometry intem performed using rotational thromboelastometry results inh increased aptt fold whereas hsa effect inh increased natem clotting time dose dependent manner inh reduced natem alpha angle degrees increased natem clot formation time coli significantly reduced natem min incubation inh prevented coli induced activation inh significantly increased intem effect extem inh significantly reduced fibrinolysis measured natem extem lysis indices conclusions supraphysiological inh concentrations dose dependent anticoagulant effects human whole blood vitro high levels inh also inhibits fibrinolysis elsevier ltd rights reserved
introduction cervical cancer serious public health concern serbia due opportunistic screening still force led twice higher average incidence rate cervical cancer europe despite fact early detection treatment services available additional cost majority women use inadequate screening services serbia objective study aimed examine link knowledge papanicolaou pap test perception barriers women participation screening materials methods study included women aged place residence city belgrade serbia attending medical examination university clinic gynecology obstetrics narodni front june december survey instrument collect data adapted questionnaire assessment knowledge barriers pap test patients divided three groups study group consisted women attending irregularly three years women never participated screening control group included women regularly participating screening results women regularly participating screening adequate knowledge pap test women irregularly never participated adequate knowledge significant statistical difference pap test awareness group respondents regularly participated comparison respondents irregularly never participated screening regarding knowledge human papillomavirus hpv women know pap test used detection hpv well abnormal pap test result may due hpv majority women poor knowledge pap test role early detection considered pap test used diagnose authors found significant statistical correlation participation women screening barriers women irregular never participated barriers lack time difficult access healthcare facilities lack knowledge pap test procedure discomfort anxiety pap test results women regularly participated prejudice choosing gynecologist unlike two groups preferred female gynecologist conclusion study showed level knowledge pap test women important factor associated regular participation screening necessary take educational measures order raise awareness women regarding risk factors well overcome fear shame ultimate aim reduce frequency mortality rate caused serbia
introduction chronic hepatitis virus hcv infection prevalent among patients inherited bleeding disorders leading cause mortality haemophilia aim evaluated efficacy safety ledipasvir sofosbuvir sofosbuvir plus ribavirin patients chronic hcv genotype infection inherited bleeding disorder methods ledipasvir sofosbuvir administered weeks patients genotype infection weeks treatment experienced cirrhotic patients genotype infection patients genotype infection received sofosbuvir plus ribavirin weeks respectively results majority treated patients severe bleeding disorder overall patients haemophilia patients haemophilia hiv coinfected sustained virologic response weeks posttreatment patients genotype infection treatment experienced cirrhotic patients genotype infection patients genotype infection patients genotype infection treatment discontinuations due adverse events aes frequent non bleeding aes fatigue headache diarrhoea nausea insomnia bleeding aes occurred patients one considered unrelated treatment conclusion treatment ledipasvir sofosbuvir patients hcv genotype infection sofosbuvir plus ribavirin patients genotype infection highly effective well tolerated among inherited bleeding disorders
introduction chronic obstructive pulmonary disease accounts large burden lung disease overlap respiratory diseases including bronchiectasis fibrosis obstructive sleep apnea osa copd alone confers morbidity mortality common features contrasting clinical outcomes occur copd overlap syndromes areas covered given large degree heterogeneity copd individual variation treatment adopted based observed phenotype turn overlaps features respiratory disease states asthma coined asthma copd overlap syndrome acos examples overlapping clinical states include bronchiectasis copd bcos fibrosis copd fcos osa copd ocos objective review highlight similarities differences copd overlap syndromes terms risk factors pathophysiology diagnosis potential treatment differences expert commentary consequence copd overlap syndromes transition traditional one size fits treatment approach necessary greater treatment stratification according clinical phenotype using precision medicine approach required light important recognize differentiate copd overlap syndromes distinct disease states compared individual diseases asthma copd fibrosis bronchiectasis
introduction clinicians practitioners caring patients chronic liver disease often unsure whether drug therapy hazard increases patient risk drug induced liver injury dili areas covered searched reports drug induced liver injury idiosyncratic intrinsic patients chronic liver disease including non alcoholic alcoholic liver disease cirrhosis reports analyzed include statin treatment patients fatty liver acetaminophen use alcoholic fatty liver antituberculous drugs patients tuberculosis viral hepatitis antiviral medications hepatitis antiretroviral medications hiv aids challenging cases found drug therapy patients decompensated liver cirrhosis expert opinion identified many case reports case series discussing potential increased risk dili patients pre existing liver disease however reports retrospective ambiguous exceptions conclude drugs seem well tolerated majority patients pre existing non cirrhotic chronic liver diseases special care needed therapies however including antiviral therapy chronic hepatitis decompensated liver cirrhosis impaired drug metabolism prospective studies warranted valid conclusions
introduction combination antiretroviral therapy cart allowed cure hiv main obstacle hiv eradication existence quiescent reservoirs several limitations cart described strict life long treatment high costs restricting western countries well development multidrug resistance given limitations impetus find cure development new treatments necessary areas covered review discuss current status several efficient molecules able suppress hiv gene transcription including tat inhibitors also assess potential new proteins belonging intriguing ding family reported potential anti hiv activity inhibiting hiv gene transcription expert opinion targeting hiv gene transcription alternative approach could overcome cart related issues emergence multidrug resistance improving cart rely identification characterization new actors inhibiting hiv transcription combining efforts use new technologies development new models preclinical studies improvement drug delivery considerably reduce drug toxicity thus increase patient adherence
introduction conventional thiopurines effective maintenance remission crohn disease ulcerative colitis however half patients intolerant unresponsive medications thioguanine alternative thiopurine shown efficacy inflammatory bowel disease particularly useful circumvent certain side effects associated conventional thiopurines example pancreatitis association nodular regenerative hyperplasia liver hindered widespread use areas covered aim outline rational use thioguanine including safety monitoring particular regard hepatotoxicity literature search performed pubmed searched full papers abstracts published english since january using following terms alone combination azathioprine thiopurine crohn disease inflammatory bowel disease nodular regenerative hyperplasia mercaptopurine thioguanine ulcerative colitis relevant papers identified reference lists selected papers expert commentary despite optimisation strategies metabolite measurements use allopurinol significant proportion patients remain intolerant thiopurines especially allergic reactions including pancreatitis subgroup patients suggest low dose thioguanine alternative therapies either parenteral expensive
introduction cow milk allergy common food allergy children symptoms usually involve skin gastrointestinal respiratory tracts gastrointestinal tract manifestations cow milk allergy nonspecific type diagnosed age groups report rare case cow milk allergy infant hypoalbuminemia malnutrition case presentation nine month old girl admitted sami ulus maternity children health diseases training research hospital ankara turkey september weakness swelling legs endured two days bilateral pretibial pitting edema laboratory data revealed albumin serum urea creatinin alanine aspartate aminotransferase levels normal urinary analysis reveal proteinuria stool samples normal stool steatocrite negative anti gliadin anti endomysium anti tissue transglutaminase antibodies negative cow milk allergy diagnosed due cow milk specific ige skin prick test results conclusions rare occasions cow milk allergy presents hypoalbuminemia diagnosis delayed allergy may impair growth quality life may even life threatening
introduction dementia heterogeneous neurodegenerative disease whose etiology results complex interplay environmental genetic factors methods searched pubmed identify meta analyses observational studies examined associations nongenetic factors dementia estimated summary effect size using random effects fixed effects model prediction interval assessed study heterogeneity square evidence small study effects excess significance results total unique associations examined applying standardized criteria seven associations presented convincing evidence associations pertained benzodiazepines use depression age late life depression frequency social contacts types dementia late life depression alzheimer disease type diabetes mellitus vascular dementia alzheimer disease discussion several risk factors present substantial evidence association dementia assessed potential targets interventions associations may necessarily causal alzheimer association published elsevier inc rights reserved
introduction depression frequent disorder characterized presence sadness loss interest pleasure everyday activities guilt feelings low self esteem sleeping eating disorders feeling tiredness lack concentration patient satisfaction prescribed treatment defined patient evaluation administration treatment results obtained aim present study assess satisfaction prescribed antidepressant treatment considering type medication dosage length treatment validated questionnaire evaluate patients satisfaction patients could ask three pharmacies located different provinces argentina method descriptive observational cross sectional study carried january february satisfaction survey given patients years old taking antidepressant medication wanted answer results patients answered survey selective serotonin reuptake inhibitors ssris commonly prescribed antidepressants paroxetine fluoxetine sertraline average dose day day day respectively sixty eight percent patients taking antidepressants first time fifty one percent treatment seven twenty four months satisfaction assessment completed survey generally observed considered treatment efficient conclusions conclude patient satisfaction antidepressant treatment high common one ssri daily morning doses least one year recommended doses
introduction efforts made reduce hiv aids related mortality delivering antiretroviral therapy art treatment however hiv patients resource poor settings still dying even art treatment study aimed explore factors associated hiv aids related mortality southwestern ethiopia method non concurrent retrospective cohort study collected data clinical records adult hiv aids patients initiated art treatment followed january december conducted explore factors associated hiv aids related mortality jimma university specialized hospital jush survival times time onset art treatment death censoring different characteristics patients retrospectively examined best fit model chosen survival data comparison native semi parametric cox regression parametric survival models exponential weibull log logistic result total hiv patients included study mostly females median age years inter quartile range iqr years estimated follow december accounted person years risk pyar resulted deaths censored individuals representing median survival time months iqr months overall mortality rate pyar pyar males pyar females weibull survival model best model fitting data lowest aic main factors associated mortality baseline age years old ahr baseline weight ahr baseline stage ahr low adherence art treatment ahr conclusion effective reduction hiv aids mortality could achieved timely art treatment onset maintaining high levels treatment adherence
introduction electroconvulsive therapy ect remains effective treatment major depressive disorder since texas maintained ect database including patient diagnoses outcomes reporting deaths within days receiving ect treatment encompassing total ect treatments administered texas previously unreported period methods descriptive analysis summarized information deaths reported year period cause death type treatment index maintenance patient demographics multiple logistic regression death incidence treatment session performed determine whether patient age sex race diagnosis year treatment associated death ect results deaths occurring within day ect treatment death rate per treatments looking deaths within days ect treatment death rate increased per treatments included deaths regardless likelihood causal association ect example accidents suicides latter leading cause death among individuals severe major depression disorders ect indicated death rate increased significantly increasing patient age male sex nonsignificant trend toward increased death amongst patientswith bipolar disorder schizophrenia versus depression conclusions data indicate ect general safe procedure respect likelihood immediate death suicide remains significant risk ect patients despite evidence ect reduces suicidal ideation
introduction emotion recognition social cognition domain impaired people schizophrenia contributes social dysfunction whether impaired emotion recognition emerges manifestation illness predates symptoms unclear findings studies emotion recognition impairments first degree relatives people schizophrenia mixed knowledge studies investigated link emotion recognition social functioning population methods study examined facial affect recognition social skills offspring parents schizophrenia familial high risk fhr compared age sex matched healthy controls ages results hypothesised fhr children exhibited impaired overall accuracy accuracy identifying fearful faces overall recognition speed relative controls age adjusted facial affect recognition accuracy scores predicted parent overall rating child social skills groups conclusions study supports presence facial affect recognition deficits fhr children importantly first known study suggest presence deficits young asymptomatic fhr children extends findings developmental stage predating symptoms findings point relationship early emotion recognition social skills improved characterisation deficits fhr children could inform early intervention
introduction eosinophilic colitis rare form eosinophilic gastrointestinal diseases occurs primary secondary allergic eosinophilic colitis gastrointestinal tract infection inflammatory bowel disease celiac disease vasculitis diagnosis based significant amount eosinophils inflammatory infiltrate colon wall aim analyze clinical picture taking account comorbidities endoscopic picture children eosinophilic colitis material methods test group consisted children average age years diagnosed eosinophilic colitis according whitington scale hospitalized gastroenterology unit department pediatrics medical university silesia katowice testing food allergies celiac disease inflammatory bowel disease gastrointestinal diseases parasitic diseases performed group children analysis concerned intensity eosinophilic infiltration colon mucosa severity clinical symptoms endoscopic picture presence inflammatory bowel disease food allergy results half tested children suffered isolated eosinophilic colitis rest eosinophilic infiltrate inflammatory bowel disease often however crohn disease endoscopic image uncharacteristic grade iii whitington scale predominant histopathological examination cases located entire large intestine higher level total ige found less half patients correlate severity eosinophilic infiltration shown severity eosinophilic infiltration correlated exacerbation clinical symptoms endoscopic image presence inflammatory bowel disease higher level antibodies asca anca found approximately children isolated eosinophilic colitis children crohn disease conclusions higher concentration total ige less half patients eosinophilic colitis indicates need improving allergy diagnosis also terms ige independent allergy presence higher levels antibodies asca anca patients isolated eosinophilic colitis indicates need observation occurrence inflammatory bowel disease
introduction studies described inequalities hormonal emergency contraception hec use developing countries thus main aim manuscript study socio demographic inequalities hec use among nicaraguan women study inequalities hec use arise exposure different forms intimate partner violence ipv methods data national cross sectional study conducted used study included data ever partnered non sterilized women separate multivariate logistic regressions form ipv conducted study different forms ipv associated hec women age residency education socioeconomic status parity current use reversible contraception included multivariate logistic regressions obtain adjusted odds ratios showing inequalities hec use results six percent women ever used hec multivariate analyses showed urban residency higher education higher socioeconomic status significantly associated higher odds ever using hec age associated decreased odds hec use key finding study controlling socio demographic factors odds using hec higher women ever exposed emotional ipv aor physical ipv aor sexual ipv aor controlling behavior partner aor exposed conclusions study provides sound evidence supporting hypothesis inequalities hec use even countries inequalities use forms contraceptive technology reduced hec use among nicaraguan women strongly influenced individual factors age residency educational level socioeconomic status exposure different forms ipv paramount actions taken diminish gaps
introduction given youth chronic pain frequently experience disruptions eating patterns may place risk disordered eating purpose study examine clinical characteristics illness course adolescents chronic pain comorbid eating disorders methods using retrospective chart review adolescents chronic pain concurrent eating disorders identified adolescents compared age gender eating disorder symptom matched adolescents eating disorder without chronic pain results majority adolescents chronic pain eating disorder primary medical diagnosis abdominal pain followed autonomic dysfunction headache although teens chronic pain eating disorder symptoms developed onset pain reported eating disorder symptoms experienced chronic pain body mass index differ groups duration eating disorder symptoms significantly longer chronic pain group discussion despite comparable severity eating disorders undetected longer periods patients chronic pain may contribute poorer prognosis implications eating disorder conceptualization detection treatment discussed
introduction globally adolescents young adults account new hiv infections hiv related deaths amongst adolescents increased adherence antiretroviral therapy art critical control viral replication preserve health however paucity research adherence amongst growing population adolescents living hiv aids alhiv southern africa examined levels self reported art adherence barriers adherence factors associated non adherence amongst alhiv malawi methods cross sectional study alhiv years attending two large hiv clinics central south eastern malawi participants self reported missed doses past week month barriers adherence completed questionnaires past traumatic events stressors disclosure depression substance use treatment self efficacy social support biomedical data retrieved existing medical records multivariate logistic regression performed identify factors independently associated self reported art adherence day recall results mean age participants years female participants reported missed art doses within past week past month commonly reported barriers adherence included forgetting travel home busy things feeling depressed overwhelmed feeling stigmatized people outside within home factors found independently associated missing dose past week drinking alcohol past month missed clinic appointment past months witnessed experienced violence home poor treatment self efficacy sex age associated adherence conclusions study nearly half alhiv reported non adherence art past month violence home alcohol use past year well poor treatment self efficacy associated worse adherence sub optimal adherence major issue alhiv compromise treatment outcomes programmes specifically tailored address challenges pertinent alhiv may help improve adherence art
introduction hereditary angioedema due inhibitor inh deficiency inh hae rare disorder characterized episodes cutaneous mucosal edema unpredictable location clinical severity belongs bradykinin mediated angioedemas requiring specific treatment excessive bradykinin release culprit behind onset symptoms prevented supplementation deficient proteins inhibition kallikrein well blocking effects bradykinin receptor administration bradykinin receptor antagonist areas covered human plasma derived inh used decades replenish deficient protein lately recombinant human inh rhc inh conestat alfa ruconest become available purpose three randomized double blind placebo controlled trials one open label three open label extension studies demonstrated safety efficacy rhc inh administered management edematous episodes occurring adolescent patients adult patients inh hae regardless location edema repeated dosing moreover pilot study shown rhc inh promising also prophylaxis edematous attacks expert opinion introduction rhc inh expanded therapeutic options available management inh hae advanced individualized therapy patients disease
introduction huntington disease genetic neurodegenerative disorder primarily affects striatal neurons striatal volume loss present years clinical diagnosis however white matter degradation may also occur prior diagnosis diffusion weighted imaging dwi measure microstructural changes associated degeneration precede macrostructural changes dwi derived measures enhance understanding degeneration prodromal pre methods part predict study pre individuals healthy controls underwent two baseline year follow dwi total sessions images processed using cutting edge dwi analysis methods large multicenter studies diffusion tensor imaging dti metrics computed selected tracts connecting primary motor primary somato sensory premotor areas cortex subcortical caudate putamen pre participants divided three cag age product cap score groups reflecting clinical diagnosis probability low medium high probabilities baseline longitudinal group differences examined using linear mixed models results cross sectional longitudinal differences dti measures present three cap groups compared controls high cap group affected conclusions largest longitudinal dwi study pre date findings showed dti differences consistent white matter degeneration present decade predicted diagnosis findings indicate unique role disrupted connectivity premotor area putamen may closely tied onset motor symptoms wiley periodicals inc
introduction hypothyroidism silent epidemic times india prevalence hypothyroidism effect hypothyroidism respiratory system debatable studies suggesting obstructive restrictive disease patterns symptoms range mild dyspnoea life threatening respiratory failure study emphasizes effect hypothyroidism dynamic respiratory functions aim find changes dynamic respiratory functions fvc fev fev pefr male female hypothyroid patients within age group years materials methods cross sectional study conducted jubilee mission medical college thrissur kerala india total number newly detected cases sexes years age group attending endocrinology outpatient department enrolled patients previous respiratory diseases history smoking excluded proforma filled followed clinical examination spirometry performed using computerised spirometer microquark data analysed paired test analysis variance anova test results mean observed values dynamic pulmonary parameters showed highly significant difference predicted mean parameters also decreased considerably age gender bmi statistically significant conclusion findings suggest respiratory abnormality newly detected cases hypothyroidism shows mixed pattern highlights investigating patient respiratory disorder thyroid status always probed effects hypothyroidism reversed proper treatment
introduction idiopathic pulmonary fibrosis ipf chronic progressive interstitial lung disease characterized irreversible fibrosis current disease pathogenesis assumes aberrant wound healing process response repetitive injurious stimuli leading apoptosis epithelial cells activation fibroblasts accumulation extracellular matrix ecm particularly lung ecm highly dynamic structure lies core several physiological developmental pathways scope review article summarize current knowledge role ecm pathogenesis ipf unravel novel mechanistic data identify future effective therapeutic targets areas covered exact mechanisms lung microenvironment activates fibroblasts inflammatory cells regulates profibrotic signaling cascades growth factors integrins degradation enzymes ultimately leading excessive matrix deposition discussed furthermore potential therapeutic usefulness specific inhibitors matrix deposition activators matrix degradation pathways also presented expert commentary gradually increasing worldwide incidence ipf still present major challenge clinical research due unknown etiopathogenesis current ineffective treatment approaches today amenable need effective therapeutic targets ecm components may represent one
introduction study aimed determine parents applied well baby clinic university hospital ankara abstain smoking around children methods data descriptive study collected november march one hundred fifteen volunteer participants either mothers fathers children five years age participated study results among total parents participated study participants fathers mothers nearly half participants stated smoked least cigarettes lifetime current smokers nobody smoked participants houses smoking prohibited balconies houses frequent two reasons participants abstain smoking around children lack information addiction conclusion major passive smoking source home parents smoking behavior prevention unhealthy behavior crucial children health long term studies cross sectional qualitative designs clarifying dynamics determine parents abstaining behavior smoking around kids needed
introduction irritable bowel syndrome ibs common gastrointestinal disorder linked asthma implying clue pathophysiology form allergic response previous studies parts world shown presence well absence association aim conducted cross sectional study find association ibs asthma indian cohort materials methods seventy patients ibs diagnosed exclusion rome iii criteria matched control group questioned respiratory symptoms along medicine section spirometry analysis reversible bronchoconstriction categorized asthmatic results prevalence asthma ibs group females males compared control group chi square test revealed odds ratio prevalence asthma ibs confidence interval nonsignificant conclusion study denies presence association ibs asthma among indian cohorts suggests regional variations present association
introduction kangaroo care involves infant placed mother father bare chest thought positive impact infants data outcomes scarce methods semi structured questionnaire inquiring use perception kangaroo care sent heads neonatology departments children hospitals neonatal ward germany results response rate among responders used performance instructions staffwere provided hygiene regulations parents special chairs provided used additional music used light therapy aromatherapy security precautions existed monitored transcutaneously restrict number kangarooing infants parallel demanded physician ward time minimum gestational age required required minimum postnatal age minimum body weight precautions taken using among normal cranial ultrasound common requirement conclusions first survey use perception exploration outcome kangaroo care medical staff germany although survey reflect opinions rather facts results show use correlates level neonatal care experience staff study provides detailed information perception conditions limitations offers useful basis research elsevier gmbh rights reserved
introduction lesbian gay bisexual transgender people still face discrimination healthcare environments physicians often report lack knowledge population specific healthcare needs fact recommendations put forward include lesbian gay bisexual transgender health medical curricula study aimed explore factors associated medical students knowledge attitudes towards homosexuality different years medical course material methods anonymous online based questionnaire sent medical students enrolled faculty medicine university porto portugal december questionnaire included socio demographic questions multidimensional scale attitudes toward lesbians gay men items homosexuality knowledge questionnaire items descriptive statistics anovas chi square tests pearson correlations used analysis results total completed responses analyzed male gender religiosity absence lesbian gay bisexual friends associated negative attitudes towards homosexuality attitudinal scores correlate advanced years medical course contact lesbian gay bisexual patients students aiming pursue technique oriented specialties presented higher scores modern heterosexism subscale students seeking patient oriented specialties although advanced years medical course correlated significantly higher knowledge scores items related lesbian gay bisexual health showed lowest percentage correct answers conclusion seems lack exploration medical students personal attitudes towards lesbians gay men also lack knowledge lesbian gay bisexual specific healthcare needs study highlights importance inclusive undergraduate curriculum development order foster quality healthcare
introduction little known association problem gambling severity psychiatric disorders among american indian alaska native individuals thus examined factors among nationally representative sample american adults usa method using national epidemiologic survey alcohol related conditions nesarc data conducted separate wald tests multinomial logistic regression analyses comparing black african american white caucasian racial ethnic groups respectively results relative american adults adults least likely report non low frequency gambling white caucasian black african american racial ethnic group likely report low risk gambling lrg white caucasian black african american racial ethnic group association risk problem gambling arpg past year axis disorder stronger among versus american adults although arpg lrg associated multiple past year axis lifetime axis psychiatric disorders american adults lrg strongly associated axis disorders particularly major depression generalized anxiety disorder nicotine dependence cluster axis particularly antisocial personality disorder disorders versus american adults discussion stronger association problem gambling severity past year psychiatric disorders among relative american adults suggests importance enhancing mental health problem gambling prevention treatment strategies may help individuals elsevier ltd rights reserved
introduction lung cancer related diseases one common causes deaths worldwide genomic based biomarkers may hardly reflect underlying dynamic molecular mechanism functional protein interactions center disease recent developments mass spectrometry made possible analyze disease relevant proteins expressed clinical specimens proteomic challenges areas covered understand molecular mechanisms lung cancer subtypes chronic obstructive pulmonary disease copd asthma others great efforts taken identify numerous relevant proteins based clinical proteomic approaches since lung cancer multifactorial disease biologically associated asthma copd among various lung diseases study focused proteomic studies biomarker discovery using various clinical specimens lung cancer copd asthma expert commentary based exploratory proteomics utilizing clinical specimens incorporate experimental bioinformatic analysis protein protein interaction also adopt proteogenomic approaches makes possible reveal molecular networks relevant disease subgroup could differentiate drug responders non responders good poor prognoses drug resistance
introduction methylene blue widely available less expensive patent blue apparently lower risk anaphylaxis objective two dyes compared regarding detection sentinel lymph node sln method prospective randomized trial involved patients invasive breast carcinoma sixty nine assigned patent blue group methylene blue group thirty five patients clinical stage iii axillary lymph nodes affected underwent neoadjuvant chemotherapy two patients excluded dye type recorded results patients tumor characteristics similar groups slns identified women group group slns affected cases group group sln node affected cases group six group time degree difficulty involved identifying sln similar groups complications allergies conclusion methylene blue performed well patent blue identifying sln breast cancer patients
introduction micrornas mirs came recently focus promising novel research targets offering new insights pathogenesis inflammatory bowel diseases ibd aims aim study identify pediatric ibd pibd characteristic mir profile serving potential crohn disease ulcerative colitis specific diagnostic pattern analyze related target genes methods small rna sequencing performed inflamed intact colonic biopsies control patients selected mirs investigated pcr complemented group order address differential diagnostic potential mirs two ibd subtypes analyze network connection differentially expressed mirs target genes mirtarbase database previous transcriptome sequencing data pediatric patient groups used results sequencing analysis identified mirs altered expression pcr analysis revealed altered expression mir discriminating inflamed mucosa intact mucosa patients expression mir elevated compared controls expression mir elevated exclusively intact region patients compared controls enrichment analysis identified main ibd related functional groups conclusions demonstrated characteristic colonic mir pattern pibd could facilitate deeper understanding pathomechanism ibd may serve diagnostic tool published elsevier ltd behalf editrice gastroenterologica italiana
introduction myocardial fdg uptake highly variable oncologic whole body fdg pet studies ranging quite intense minimal distribution intense heterogeneous myocardial fdg uptake undesirable may interfere visual quantitative evaluation tumoral invasion metastases pericardium myocardium adjacent mediastinal structures diet well many factors assumed influence myocardial fdg uptake using multivariate model tried identify predict main factors influencing cardiac fdg uptake patients referred oncologic pet evaluation methods total patients referred oncologic fdg pet scan enrolled study patients randomly allocated two groups according diet instructed follow hour period imaging one hundred seven cases routine diet number patients low carbohydrate high fat lchf diet included patients fast hours imaging weight height blood glucose heart rate systolic diastolic blood pressure measured radiotracer injection visual quantitative analysis done imaging pattern fdg uptake well standardized quantitative value cardiac uptake determined case results frequency undesirable cardiac fdg uptake lchf group significantly less group well consumption cardiotoxic chemotherapeutic agents benzodiazepines beta blockers significantly associated higher intensity myocardial fdg uptake undesirable finding less evident cases diabetes mellitus multivariate logistic regression model including mentioned variables revealed diet significant independent factor predicted undesirable myocardial fdg uptake conclusion lchf diet hours pet imaging controllable independent factor influencing intensity pattern myocardial fdg uptake recommended optimal preparation suppress cardiac fdg uptake
introduction obesity rapidly becoming pandemic poses serious health risk individuals abdominal obesity quite common india prime risk factor diseases like diabetes coronary artery disease gastroesophageal reflux disease gerd osteoarthritis etc complex multifactorial aetiopathogenesis gerd exists presence obesity current study focuses high body mass index bmi marker obesity risk factor gerd aims better understanding complex association aim study association bmi symptoms well gross endoscopic appearance gastroesophageal reflux disease materials methods prospective cross sectional study carried tertiary care hospital maharashtra india january june total patients referred upper gastrointestinal endoscopy due dyspeptic symptoms two months duration selected bmi weight kilograms square height metres calculated patients classified normal weight bmi overweight bmi obese bmi frequency severity gerd symptoms assessed self administered questionnaire data typical atypical symptoms gerd collected upper endoscopy done patients based gross endoscopic appearance disease divided endoscopy negative reflux disease enrd true gerd per los angeles staging system association bmi frequency severity type symptoms gerd also bmi gross endoscopic oesophagitis studied using various statistical tests tests two tailed confidence level value considered statistically significant results typical symptoms heartburn acidic regurgitation present subjects frequency severity dyspeptic symptoms increased significantly increasing bmi based endoscopic gross appearance oesophageal mucosa participants enrd erosive disease gerd high bmi statistically significant relationship occurrence enrd gerd statistically insignificant relationship classification system endoscopic oesophagitis conclusion prevalence frequency severity symptoms gerd increases increase bmi erosive oesophagitis significant correlation increasing bmi staging classification endoscopic erosive oesophagitis independent bmi patients
introduction osteotomy internal fixation usually effective way treat malunion lateral tibial plateau fractures accuracy osteotomy still challenge surgeons report series prospectively study osteotomy treatment malunion lateral plateau fractures aid printing technology methods total patients malunion lateral tibial plateau fractures enrolled study september september completed follow image data used reconstruction individually printed models used accurate measurements detail osteotomy procedures planning premeditated operation plan osteotomy operations performed patients invited follow examinations weeks intervals weeks months results mean age patients years range years cases result fall injuries traffic accidents sports injuries among cases one accompanied craniocerebra trauma one pelvic fracture one accompanied according schatzker tibial plateau classification original fracture type type type type iii lateral tibial plateau collapse ranges average operations successfully completed average operation time min range min average intraoperative blood loss range mean follow time months range months average healing time osteotomy fragments weeks range weeks difference preoperative postoperative rasmussen scores statistically significant patients obtained functional recovery complications conclusion printing technology helpful accurately design osteotomy operation reduce risk postoperative deformity decrease intraoperative blood loss shorten operation time effectively improve treatment effect published elsevier ltd
introduction pediatric burns due abuse unfortunately relatively common accounting cases abuse annually goal evaluate year experience evaluation management victims abuse north texas area methods prospectively maintained database containing records admissions queried patients aged less years patients admitted management non burn injury excluded analysis results pediatric burn admissions due abuse children non accidental injuries tended younger years male scald common mechanism injury overall also predominant cause inflicted burns multivariate logistic regression identified age gender presence scald contact chemical burn injury hands bilateral feet buttocks back perineum significant predictors abuse victims abuse also found worse outcomes including mortality adjusting age mechanism injury burn size abuse remained significant predictor mortality conclusions clinicians approach burn injuries young children high index suspicion particular scalds injuries buttocks perineum bilateral feet provoke suspicion burns due abuse associated worse outcomes including length stay mortality published elsevier ltd
introduction people disabilities often identify professionals stigmatic views significant barriers accessing mainstream services study aimed examine differences stigmatic attitudes held social workers toward individuals intellectual disabilities mental illness dual diagnosis methods one hundred fifty eight social workers responded three versions structured questionnaire participants provided random order vignettes describing individual completed attribution questionnaire results results revealed significant effect disability type individuals perceived responsible condition individuals individuals perceived dangerous social workers endorsed coercive segregating behaviors toward individuals toward differences found helping avoidant behaviors relation disability type correlations stigma constructs found across three disabilities conclusions findings discussed light social workers obligation assist individuals realize rights full social civil inclusion given obligations expected set aside personal views provide help clients regardless diagnosis
introduction pharmacists timely provision emergency contraception requires critical thinking sensitive patient centred approach aim explore impact socratic teaching pharmacy students professional judgement critical thinking patient centredness relation provision methods one hundred fifty three first second year graduate entry master pharmacy students representing pre post teaching groups presented questionnaire comprising array challenging hypothetical scenarios involving pharmacy requests results one hundred forty two students responded first second year students showed significant differences intentions supply refer another health professional student comments demonstrated differences social professional judgement pre post teaching justifications provided explain choices indicated post teaching students better understood context impacts decision making especially delivering patient centred care conclusion socratic teaching enhances students critical thinking patient centredness relation hypothetical provision
introduction postmenopausal women knowledge vulvar vaginal atrophy vva available treatment options historically inadequate recent direct consumer marketing educational efforts would expected increase awareness treatment options aim compare results women empower survey available vva surveys assess progress women understanding approaches treatment vva methods women empower survey internet based survey women vva symptoms assessed women awareness vva behaviors attitudes associated symptom treatment main outcome measures survey results compared previously published results revealing vaginal effects mid life reveal women voices menopause wvm vaginal health insight views attitudes viva clarifying vaginal atrophy impact sex relationship closer real women views treatment options menopausal vaginal changes revive surveys results results women empower survey consistent past vva surveys showed postmenopausal women generally failed recognize vva chronic progressive process reluctant discuss vaginal sexual symptoms health care professionals hcps however women indicated strong desire accurate medical information vva health care professionals willingness learn hcps would initiate conversation women believed vaginal symptoms normal part aging need cope symptoms united states women concerned safety related issues including increased risk breast cancer side effects systemic absorption conclusion women empower survey demonstrates reinforces even multimedia marketing educational strategies years major vva surveys minimal progress made toward increasing women awareness knowledge understanding vva based data focus initiating discussions education postmenopausal women better comprehend vva chronic progressive medical condition aging symptoms associated vva benefitrisk profile regarding treatment options warranted copyright authors published elsevier inc behalf international society sexual medicine
introduction quadriceps strength arthroscopic knee procedures frequently diminished several years postoperation blood flow restriction bfr training uses partial venous occlusion performing submaximal exercise induce muscle hypertrophy strength improvements purpose study evaluate bfr postoperative therapeutic intervention knee arthroscopy methods randomized controlled pilot study comparing physical therapy without bfr knee arthroscopy conducted patients underwent sessions supervised physical therapy subjects followed postoperative protocol addition additional bfr exercises outcome measures included thigh girth physical function measures knee osteoarthritis outcome score koos veterans rand item health survey strength testing bilateral duplex ultrasonography used evaluate deep venous thrombosis preintervention postintervention results seventeen patients completed study significant increases thigh girth observed bfr group proximal patella physical outcome measures significantly improved bfr group timed stair ascent improvements greater conventional therapy koos subscales significantly improved bfr group greater improvement seen mental component score bfr group displayed approximately fold greater improvements extension flexion strength compared conventional therapy adverse events observed study conclusions study suggests bfr effective intervention knee arthroscopy investigation warranted elucidate benefits intervention populations greater initial impairment
introduction reasoning biases jumping conclusions jtc overconfidence errors well replicated patients delusions however relation dopaminergic activity central pathophysiologic models psychosis yet investigated study aimed examine effects dopaminergic agonist dopa dopaminergic antagonist haloperidol jtc bias overconfidence errors single dose administration healthy individuals methods study used randomized double blind placebo controlled way crossover design participants healthy individuals aged years variables interest draws decision probability threshold decision computerized variant beads task number high confident incorrect responses visual memory task results significant effects substance draws decision probability threshold decision significant effect emerged high confident incorrect responses memory task pairwise comparisons indicated significant reduction number high confident incorrect responses administration haloperidol dopa placebo conclusions first study investigate direct effects dopaminergic drugs reasoning biases jtc bias overconfidence errors showed differential pattern dopaminergic modulation suggesting represent different facets reasoning abnormalities interact produce delusions susceptible individuals
introduction retinoid signaling argued favorable effects alzheimer disease studied role chronic intracerebroventricular icv injection trans retinoic acid atra amyloid beta beta model methods adult male rats weighing divided groups six groups rats received atra rat icv dmso rat icv bilaterally chronic manner times twice week forty eight hours following last injection memory performance assessed using passive avoidance paradigm one group received beta rat icv bilaterally control group received dmso rat icv twenty days later memory performance assessed three groups rats received beta rat icv atra rat icv dmso chronically times twice week another group received dmso rat icv dmso chronically times twice week results atra doses rat impaired memory retrieval decreasing step latency stl increasing time spent dark compartment tdc significantly however moderate doses rat change memory performance atra rat increased stl decreased tdc nst beta treated rats significantly compared group received beta dmso conclusion results propose potential prophylactic effect atra icv beta model indicate prominence retinoic acid signaling target prevention
introduction serum beta glucan bdg assay proposed adjunct rapid diagnosis invasive fungal infection ifi however false positive results reported following transfusion blood products adults aims assess relationship blood product transfusion elevated bdg neonates method retrospective study including neonates weeks fungal colonization infection bdg assay performed suspicion ifi patients classified transfusion transfusion groups depending whether transfused clinical biochemical microbiological characteristics recorded bdg assay considered positive statistical analyses bivariate multivariate logistic regression results median iqr one hundred thirty three infants included gestational age weeks birth weight bdg higher transfusion group transfusion group false positive bdg assay results associated red blood cells rbc fresh frozen plasma ffp transfusions conclusion bdg increased rbc ffp transfusions neonates leading overdiagnosis ifi fungal colonization status peripheral sites central cultures could help reduce risk misdiagnosis
introduction several selective progesterone receptor modulators sprms show promise several areas medicine work summarized areas covered since publication reviews several developments taken place field reproductive medicine first emergency contraception two sprms clinically utilized today mifepristone mfp ulipristal acetate upa mfp available following unprotected intercourse dose significantly effective levonorgestrel lng metanalysis use upa versus lng unprotected intercourse failure rates versus reported second contraception daily dose mfp block ovulation several mfp regimens tested including vaginal ring releasing mfp third preoperative administration women harboring leiomyomas clinical testing several sprm shown decrease uterine leiomyomas size substantially reduce uterine bleeding sprm induce unusual specific endometrial appearances many believe changes cause concern issue remains controversial expert opinion sprms effective preoperative treatment uterine leiomyomas
introduction severe therapy resistant asthma area recent advances understanding percolating improvements management areas covered review covers recent definition approach diagnosis severe asthma differentiation difficult treat asthma recent advances phenotyping severe asthma ensuing changes management approaches together introduction new therapies covered review recent literature expert commentary ascertaining diagnosis severe asthma patients need treated adequately existing therapies management approach severe asthma comprises phenotyping step definition either allergic eosinophilic severe asthma targeted therapies currently available lead precision medicine approach management severe asthma
introduction smoking currently considered one biggest risk factors development various diseases early death fourier transform infrared ftir spectroscopy valuable tool analysis biofluids saliva considered useful diagnostic purposes aim study evaluate effect smoking cessation saliva composition ftir spectroscopy methods analyzed saliva participants two groups smoker group made chronic smokers former smoker group made individuals stopped smoking members groups similar smoking history results results showed differences spectral intensity groups however spectral peaks slightly increased group smokers bands dna indicating modification content cell necrosis also increased mannose phosphatase molecule expressed prostate breast carcinomas former smoker group peak thyociante decreased band referring collagen increased intensity indicates better tissue regeneration capacity conclusion considering results fact tobacco intake similar groups concluded recovery tissue regeneration capacity smoking cessation study period although effects found smokers persisted bodies given smoking elsevier rights reserved
introduction spinal epidural hematoma seh rare disease causes cord compression neurologic deficit spontaneous seh related minor trauma bleeding disorders anticoagulant medications posttraumatic seh associated low energy spine hyperextension injuries patients ankylosing spinal disorders ankylosing spondylitis diffuse idiopathic skeletal hyperostosis dish variant named atypical dish like seh reported objective describe management diagnosis treatment unusual seh case patient causing delayed neurologic deficit rigid atypical dish like spine case description elderly woman prior antiplatelet therapy presented delayed neurological deficit suffering trauma falling computed tomography imaging studies reveal hyperextension fracture pattern signs mimic dish missed standard ray images magnetic resonance study demonstrates posterior epidural mass compatible seh thoracic spine cord compression using midline posterior approach urgent intervention left multiple partial unilateral decompressive laminectomy long instrumented fusion performed achieving spinal stability neurological improvement observed conclusion patients rigid spine sustain low energy injuries may prone fracture epidural hematoma especially take anticoagulant medications imaging studies including scans reviewed carefully rule occult fracture urgent early surgical hematoma drainage instrumented fusion must performed achieve stability functional recovery
introduction stress anxiety depression psychiatric pathological conditions leave short term long term effects pregnancy mother child without clinical symptoms current study conducted investigate effect anger management counselling stress controlling mental health pregnant women admitted health centers bandar abbas city methods study quasi experimental study conducted pregnant women educational centers selected using cluster sampling method centers intervention centers control educational intervention consisted four face face sessions booklet reminder sms minutes week four weeks completion education post test performed research tools consisted demographic questionnaire standard mental health assessment questionnaire completed one month counselling pregnant women finally data extracted analyzed using spss software results mean score mental health physical dimensions anxiety social function depression intervention control group showed statistically significant differences two groups conclusion counselling mothers prenatal cares anger management education stress management improve mental health pregnant women order improve health family significantly
introduction studies biomaterials involve assays aimed assess interactions biomaterial cells seeded surface however morphology biomaterials heterogeneous could tricky standardize results among different biomaterials classic plastic plates light decided create means computer aided design cad technology standardized sample model equal shape sizes able fit classic shape wells tissue culture plate tcp methods design sample consists hole top order allow injected cells settle without able slip sides sample bottom tcp wells cad project made using software pro engineer sample totally fill wells well tcp dental pulp stem cells used assess ability different sample support promote cell proliferation results twelve titanium gold palladium zirconium oxide customized samples designed means software cam powermill importing stl file created pro engineer software proliferation rate tested scaffolds showed similar control group customized shape conclusion think method useful test different types scaffolds greater accuracy measurements desirable order verify cell behavior scaffolds innovative method improve standardization process evaluation cell behavior different biomaterials open way reliable tests biomatrices functionalized drugs growth factors applied future regenerative medicine
introduction surgeosight dedicated intra operative hand held gamma camera designed manufactured team used lymphoscintigraphy although conventional gamma cameras widely used lack capability sentinel lymph node sln imaging operation room like conventional gamma cameras necessary calibrate surgeosight linearity distortion energy flood correction main objective study develop implement three techniques linearity energy uniformity corrections methods camera made pixelated cesium iodide sodium activated csi scintillation crystal element size along hamamatsu flat panel multi anode channels photomultiplier tube triple corrections required lookup tables luts generate three luts one uncalibrated acquisition necessary linearity distortion correction based localization physical pixels crystal thin plate spline interpolation estimate amount distortion energy correction lut simply photo peak map incoming events estimated using self organizing map technique results results showed improvements qualitatively quantitatively extrinsic energy resolution enhanced integral uniformity differential uniformity uniformity correction useful field view ufov measured respectively conclusion results substantiated correction techniques guarantee uniform accurate output surgeosight desirable intra operative localization sentinel lymph nodes breast cancer also imaging superficial tumors
introduction surveys collect information injuries often focus single serious event help limit recall error reduce survey length however mask less serious injuries result biased incidence estimates specific injury subcategories methods data health behaviour school aged children hbsc survey canadian hospitals injury reporting prevention program chirpp used compare estimates sports injury incidence canadian children results hbsc data indicate children report sustaining sports injury required emergency department visit however details collected child serious injury children multiple injuries requiring visit may sports injuries went unreported rate seen underestimate much corresponding chirpp surveillance data indicate incidence potential masking bias also highlighted analysis injuries attended health care providers conclusion one serious injury line questioning induces potentially substantial masking bias estimation sports injury incidence limits researchers ability quantify burden sports injury longer survey recall periods naturally lead greater masking design future surveys take issues account order accurately inform policy decisions direction future research researchers must aware limitations
introduction symptomatic uncomplicated diverticular disease sudd one possible clinical manifestations diverticular disease common disorder characterized chronic abdominal symptoms ranging lower left abdominal pain alteration bowel habit significantly reduce quality life subject affected present article aims review current data medical management sudd evidence acquisition analyzed existing literature factors involved pathogenesis sudd highlighted possible target treatment treatment sudd direct relieve chronic symptoms prevent diverticulitis complications particular focused role probiotics fiber diet mesalazine rifaximin two aspects setting conducted pubmed search guidelines systematic reviews meta analyses updated information october evidence synthesis topic evaluated according best evidences available best results seemed obtained combined therapies particular rifaximin associated high fiber diet regimen seems guarantee better symptoms control compared fiber alone effective preventing acute diverticulitis contrary clear evidences efficacy mesalazine probiotics available conclusions results studies available literature controversial debatable reason clear defined algorithm treatment sudd yet defined randomized double blind placebo controlled study necessary
introduction association primary monosymptomatic nocturnal enuresis pmne behavioral disorders highlighted frequently suggesting psychiatric origin hand difference incidence mental disorders children pmne controls although psychological genesis could provide additional secondary forms child might react stressful events resumption involuntary urination night possible alteration bowel control due high vulnerability stressors purpose study assessing stressful events life sample children pmne materials methods subjects pmne males females mean years recruited consecutively subjects evaluated presence stressful events icu test coddington life events scales cles control group consists typically developing children males females mean years results individuals enuresis show significant difference prevalence stressful events control group chi square table conclusions results first time show pmne regarded independent state stress factors suggesting represents stress factor affect proper psychological neuropsychological development children
introduction autonomic nervous system ans involved regulating social behavior autism spectrum disorder asd characterized alterations social behavior reduced physiological response threat hypothesized adolescents asd would show reduced ans response social threat methods eighteen males asd thirteen males typical development ages completed social threat paradigm wearing impedance cardiography apparatus calculated pre ejection period pep tested group differences pep response social threat also conducted correlation analyses pep change scores clinical symptom scales results effect diagnosis change pep baseline onset social threat greater changes pep compared asd pep change score social communication questionnaire adhd problems subscale child behavior checklist correlated conclusions findings suggest reduced arousal response social threat asd preliminary evidence reduced sympathetic activation associated increased social behavior symptoms elsevier ltd rights reserved
introduction main objective study describe qualitatively quantitatively different immune lymphocyte phenotypes patients renal disease treatment anti material methods two cohorts transplanted autoimmune kidney patients compared began treatment rituximab matched sex age general clinical parameters non treated control kidney patients different analyses performed lymphocyte subpopulations cell subpopulations serum levels baff april rituximab anti rituximab polymorphism cda different time points type analysis baseline day iii three six months post anticd results depletion cell subsets analysed observed preferentially decreasing memory cells switched memory cells plasmablasts significant decreased percentage lymphocytes observed significant decrease percentage memory cells increase naive cells also observed significant increase april observed well positive correlation april levels differential cells presence cda valine variant induced greater changes variations total cell naive subpopulations conclusion results highlight treatment renal disease rituximab affects cells particularly naive memory balance april could also secondary marker treatment sequential analysis phenotypic alterations cells could help patient management although studies identify periods remission clinical relapse warranted elsevier gmbh rights reserved
introduction main objective study develop validate new olfactory measure assesses influence olfaction several emotional behavioural cognitive issues relational scale olfaction erol secondary objective explore relationship olfactory function anxiety depression symptoms means erol hospital anxiety depression scale hads positive relationship anxiety symptoms olfactory function hypothesized regarding depressive symptoms significant relationship olfactory scores expected method psychometric properties erol scale correlations hads erol tested sample general population results erol showed adequate level test retest reliability icc good internal consistency cronbach alpha convergent validity olfactory measures satisfactory one factor solution found scale hads showed significant relationship erol analysis dimensions revealed anxiety subscale correlated significantly moderately olfactory measure conclusions given erol displayed good psychometrical properties appears suitable tool assess olfactory function general population relationship olfactory scale anxiety symptoms found study interesting issue requires research
introduction common humoral immunodeficiency iga deficiency one first papers addressing cellular molecular mechanisms underlying iga deficiency indicated immature iga positive lymphocytes present patients suggests genetic background iga still intact class switching take place moment ruled genetic well environmental factors involved areas covered clinical presentation biological functions iga management iga deficiency reviewed iga deficient patients relationship loss function mutation taci transmembrane activator calcium modulating cyclophilin ligand interaction gene found many genes also associated gut microbiota important environmental trigger iga synthesis expert commentary expression iga deficiency due genetic environmental factors role gut microbiota excluded
introduction past years seen dramatic advances understanding molecular pathogenesis bcr abl negative myeloproliferative neoplasms mpns knowledge come novel molecularly targeted therapies jak inhibitors may decrease symptoms improve quality life patients mpns despite advances progression disease acute leukemic blast phase remains difficult predict even difficult treat high rates disease relapse mortality areas covered performed literature review known risk factors progression mpns towards blast phase treatment options transformed disease including approved investigational agents herein review current literature suggest strategies improving outcomes future expert commentary understanding biologic basis transformation mpns chronic blast phase needed order predict prevent treat cases patients mpns blast phase encouraged participate clinical trials whenever possible
introduction philadelphia chromosome negative myeloproliferative neoplasms mpn mainly comprise polycythemia vera essential thrombocythemia myelofibrosis primary post therapy focuses minimizing thrombosis bleeding risk prolongation survival important goal different cytoreductive agents employed high risk jak inhibtior ruxolitinib cornerstone therapy histone deacetylase inhibitors hdaci pleiotropic agents diverse epigenetic non epigenetic actions selectively transformed cells number hdaci investigated mpn areas covered mechanisms action hdaci neoplastic cells summarized preclinical rationale data supporting development mpn specifically examined particularly synergism jak inhibitors major findings clinical trials hdaci alone combination ruxolitinib mpn discussed particular attention toxicities disease modifying effects expert opinion hdaci clearly active mpn good preclinical rationale combination ruxolitinib promising long term tolerability agents important concern development appears unlikely
introduction prevalence nonalcoholic fatty liver disease nafld patients type diabetes high associated poor prognosis hepatic steatosis results consequence excessive hepatic lipid accumulation correlates insulin resistance lipotoxicity subsequent oxidative stress inflammation apoptosis fibrosis areas covered article presents main pathophysiologic mechanisms currently available drugs evaluated therapeutic effects nafld nonalcoholic steatohepatitis nash drugs development target relevant pathogenetic pathways however date particular drug approved treatment nafld patients expert commentary early recognition intervention essential ameliorate disease progression specific recommendations still needed nafld nash screening diagnosis therapeutic algorithm patients lifestyle optimization significant weight loss key intervention patients nafld pioglitazone liraglutide vitamin oca pentoxifylline proven histological improvements nash omega pufas shown decrease liver fat specific recommendation made treatment nash perhaps combination agents target different pathogenic pathways needed better control disease progression robust evidence agents still needed
introduction scarce studies time series analysed short term association emergency hospital admissions due alzheimer disease environmental factors objective analyse effect heat waves noise air pollutants urgent hospital admissions due madrid methods longitudinal ecological time series study performed dependent variable emergency hospital admissions occurred madrid period independent variables daily mean concentrations air pollutants maximum daily temperature degrees daily night noise levels relative risk increment interquartile range attributable risk values calculated glm poisson link results findings indicated concentrations lag heat wave days lag associated hospital admissions conclusion reduction patients exposure levels special care patients heat wave periods could result decrease emergency admissions related health care costs elsevier rights reserved
introduction several important interactions antiepileptic drugs aeds hormonal contraception need carefully considered women epilepsy wwe practitioners many aeds induce hepatic enzymes decrease efficacy hormonal contraception addition estrogen containing hormonal contraception increase metabolism lamotrigine commonly prescribed aed women childbearing age intrauterine device iud highly effective form reversible contraception without aed drug interactions considered many contraceptive choice wwe women epilepsy planning pregnancy require effective contraceptive counseling include discussion iud guidelines however deliver recommendations objective study explore hypothesis contraceptive counseling neurologist influence contraceptive choices wwe particular explored relationship contraceptive counseling epilepsy clinic likelihood patients would obtain iud methods conducted retrospective chart review female patients age seen institution initial visit ascertain type contraceptive counseling patient received well aed use contraceptive methods patients pregnant planning pregnancy first visit excluded analyses patients surgical sterilization also examined subgroup patients least follow visits evaluate efficacy epileptologists counseling specifically looked likelihood patient obtained iud based type counseling received fisher exact tests assessed associations counseling type whether patients obtained iud results three hundred ninety seven women met criteria inclusion female patients counseled contraception first visit women counseled first visit unlikely counseled subsequent visits ever received counseling fourth visit patients completed visits counseled iud optimal contraceptive choice generally counseled contraceptive interactions counseled contraception women epilepsy received iud specific counseling significantly likely switch iud compared women received contraceptive counseling women epilepsy received iud specific counseling also tended switch iud often women receiving general counseling aeds contraceptive interactions significant difference likelihood acquiring iud general counseling counseling groups conclusions contraceptive counseling epileptologists specific mention iud significantly associated patient selection iud contraceptive method suggests neurologists play important role patients contraceptive choices elsevier inc rights reserved
introduction thrombolytic therapy acute ischemic stroke approved treatment acute stroke past two decades however identification predictors poor outcome intravenous alteplase therapy acute stroke patients matter research present study conducted aim identifying poor prognostic factors patients acute ischemic stroke patients methods data acute stroke patients treated alteplase gathered identify factors independent predictors poor outcome outcome dichotomized using modified rankin scale mrs score national institutes health stroke scale nihss score months treatment good outcome mrs poor outcome mrs predictors poor outcome analyzed results good outcome mrs score seen patients median age poor outcome mrs score seen patients median age years statistically significant presence risk factors hypertension diabetes dyslipidemia smoking alcohol intake history stroke coronary artery disease rheumatic heart disease among two groups seem influence outcome severity stroke assessed nihss score time presentation significantly higher among patients poor outcome conclusion advance age higher nihss score time onset stroke independent predictors poor outcome thrombolysis alteplase treatment acute ischemic stroke patients
introduction evaluate initial application recently published three step framework implementing trauma informed care tic pediatric health care network applying framework spread methods steps framework established commitment health care network leadership initial interest tic among clinical providers step set evidence based training goals created associated tic training content step step health care professionals health care teams participated single session hour training covered psychological impact injury illness related trauma identification traumatic stress symptoms respond children exposed potentially traumatic events concomitant quality improvement project allowed assess potential changes training participants favorable attitudes toward integration tic confidence delivering tic results compared pretraining participants demonstrated increases attitude toward tic cohen confidence delivering tic cohen discussion trainings effective achieving proximal goals targeting attitudes confidence thereby demonstrating feasibility clinical relevance tic training implemented according three step framework future research examine methods training reach wide audiences promote systematic change evaluate changes patient outcomes associated providers implementation tic
introduction transfusion transmissible infections ttis human immunodeficiency virus hiv hepatitis virus hbv hepatitis virus hcv syphilis pose threat blood safety developing country like india aim determine prevalence ttis among healthy donors andaman nicobar islands india help determination population subset focused enhancing blood donor pool materials methods retrospective cross sectional study conducted voluntary replacement donors tertiary health care centre andaman nicobar islands period three years donor blood screened hiv hbv hcv syphilis malarial parasite using rapid kits elisa results donors males females voluntary donors replacement donors majority screened donors belonged age group donors seropositive among hiv positive hcv positive hbsag positive syphilis positive positive malarial antigen yearly prevalence seropositivity three consecutive years conclusion high prevalence ttis among healthy donors safe blood transfusion still challenge developing countries continues place unacceptable burden health sector need encouragement voluntary blood donation strict donor selection criteria sensitive screening tests minimize ttis indian setting
introduction tumor necrosis factor alpha tnf antagonists shown effective treatment chronic inflammatory rheumatic conditions use anti tnf agents combined improved diagnosis aggressive regimens regular monitoring substantially improved patient outcomes however biological agents immunogenic resulting formation anti drug antibodies adas neutralize drug activity leading loss response potential relapse addition adas also cause serious adverse events infusion hypersensitivity reactions areas covered narrative review studies investigating immunogenicity clinical safety implications tnf antagonists confirms structural pharmacological differences agents results differences probabilities outcomes immunogenicity expert opinion anti tnf therapies shown trigger auto immune responses lupus like syndrome despite fact biological agents potential immunogenic reactions number predisposing factors identified mechanisms remain completely clarified assessment immunogenicity clinical relevance matter discussion many questions regarding immunogenicity still need answering better optimize anti tnf treatment patients chronic inflammatory rheumatic disease
introduction unintended pregnancy unsafe abortion pose major reproductive health challenge adolescents emergency contraception safe effective preventing unplanned pregnancy objective study assess students knowledge use emergency contraception methods cross sectional study carried ilorin nigeria using multi stage sampling method data collected using pre tested semi structured self administered questionnaire knowledge scored analysed spss version used data analysis value considered statistically significant results respondents good knowledge emergency contraception majority respondents never used emergency contraception majority ever used emergency contraception used incorrectly using hours sexual intercourse conclusion knowledge emergency contraception prevalence use low contraceptive education introduced early school curriculum adolescents
introduction vulvovaginal candidiasis vvc common medical health problem adult women commonly caused candida albicans change fungal profile sabouraud dextrose agar sda common culture medium used mixed fungal infection may missed detected easily using chromogenic culture medium aim know fungal profile vulvovaginal candidiasis using candida chromagar antifungal susceptibility pattern patients attending tertiary care hospital materials methods culture confirmed cases vvc presented department obstetrics gynaecology jawaharlal institute postgraduate medical education research jipmer puducherry india july december included cross sectional study two high vaginal swabs collected inoculated sda candida chromagar media mumbai india overnight incubation colonies counted colour colonies recorded candida chromagar candida spp identified sugar fermentation assimilation tests conventional tests antifungal susceptibility tests performed disc diffusion method using fluconazole voriconazole per clinical laboratory standards institute clsi guidelines results total culture confirmed cases detected clinically suspected vvc cases candida glabrata common isolate followed candida tropicalis candida albicans candida krusei candida parapsilosis one mixed infection glabrata albicans identified candida chromagar mixed fungal infection observed positive culture vvc cases antifungal susceptibility testing revealed isolates candida spp resistant susceptible dose dependent respectively fluconazole increase resistant fluconazole increased isolation glabrata strains strains candida spp susceptible voriconazole conclusion glabrata common causative agent vvc tertiary care hospital chromogenic culture medium facilitates detection mixed fungal infection vitro susceptibility testing used guide treatment especially cases non albicans candidiasis
introduction work related stress one major concerns occupational safety health indeed workplace stress may affect workers well lead health issues estimated half work absence due work related stress disorders objective study investigate associations work related stress risk factors set health outcomes sample public sector employees material methods employees filled self report questionnaire work related stress musculoskeletal pain stressrelated disorders logistic regressions conducted pain disorders outcome variables health safety executive management standards indicator tool hse scales predictors results excessive workload associated neck pain shoulder pain anxiety depression symptoms employees exposed risk role dimension reported higher neck pain gastrointestinal disorders hostile working relationships associated shoulder pain gastrointestinal disorders lack managers support turned risk factor insomnia conclusions workplace stress plays role incidence specific health outcomes use validated work related stress assessment instruments hse management identify critical intervention targets work design domains improving workers health well elsevier ltd rights reserved
introduction mindful clinicians resilient likely provide patient centered care aimed enhance clinicians well offering mindfulness based stress reduction mbsr course teaches mindfulness stress management determine whether impacted subsequent medical encounters methods longitudinal cohort study clinicians mbsr taught certified instructor pre mbsr post mbsr online questionnaires assessed burnout depression stress meaningfulness mindfulness patients independently rated clinicians using rochester communication rating scale rcrs clinical encounter clinician took mbsr course nine medical doctors audiorecorded consultations mbsr tapes coded analyzed independent team using roter interaction analyses system results significant reductions stress burnout found increases mindfulness meaningfulness decrease stress correlated less judgmental attitudes less reactivityfacets mindfulness decrease emotional exhaustion correlated acting awareness less judgmental attitudesfacets mindfulness patients perceptions clinical encounter suggested patient centered care improved mbsr decreased depersonalization significantly associated rcrs subscale understanding patient experience illness time points doctors dominated exchange patient centered discussion mindfulness direct positive impact clinicians well clinicians experienced less depersonalization patients reported better understood
introduction progression fibrosis chronic hepatitis chc multifactorial process high adverse effects cost standard health care increase demand discover new predictors progression fibrosis chc patients study aims establish relation angiogenic marker vascular endothelial growth factor vegf activated hepatic stellate cells hscs represented expression smooth muscle actin sma whether markers used predictors progression fibrosis patients chc materials methods histopathologic immunohistochemical analyses used examining morphology expression vegf sma chc biopsies procured chc patients multivariate analysis used correlate protein expression staging grading liver fibrosis cutoff values sma vegf determined receiver operating characteristics curve results positive correlation vegf hscs expressing sma factors correlated stage fibrosis using receiver operating characteristics curve vegf area curve sma area curve positive predictors moderate severe fibrosis conclusions study demonstrates relation vegf expression activated hscs denoted expression sma chc biopsies together used predictor progression fibrosis
introduction transient cortical blindness tcb rare complication angiography proposed related contrast extravasation present first case tcb angiography evaluated using serial arterial spin labeling magnetic resonance perfusion aslmrp susceptibility weighted imaging swi case report year old woman dyslipidemia treated left vertebral artery dissection months previously presented dizziness right hemiparesis magnetic resonance imaging brain revealed suspected dissection segment left vertebral artery cerebral angiography performed using total nonionic contrast material approximately hours procedure patient started complaining slight headache nausea along bilateral cortical blindness hour aslmrp swi brain respectively revealed hypoperfusion increased oxygen extraction fraction bilateral occipital lobes patient gradually regained vision next hours follow aslmrp swi revealed normal perfusion normal swi findings respectively conclusions hypoperfusion aslmrp increased oxygen extraction fraction swi results derived patient presenting tcb demonstrated thus hypothesize endothelin related vasoconstriction pathophysiologic mechanism tcb best knowledge report first describe aslmrp swi findings tcb angiography
introductionafter premenopausal risk reducing salpingo oophorectomy rrso prevent ovarian cancer non cancer related morbidity mortality may increased sex hormones replaced several guidelines recommend systemic hormone replacement therapy hrt women expected age menopause aimed study use hrt rrso material methodsparticipants women rrso postmenopausal controls subsample controls undergone bilateral salpingo oophorectomy bso participants completed questionnaire regarding hrt use compared hrt use rrso group bso controls using logistic regression resultsamong women aged years without history breast cancer rrso group bso controls reported current use systemic hrt odds ratio confidence interval among hrt users systemic estrogen used rrso bso control groups respectively among women aged years rrso group bso controls years used systemic hrt doctors aware practice prescribe systemic hrt indicated
introductiondespite high prevalence chronic pain individuals infected htlv predictive protective factors development still unclear objectiveto identify factors associated chronic pain individuals htlv methodsthis cross sectional study conducted reference center treatment patients infected htlv salvador bahia brazil study included individuals infected htlv years excluded difficulty respond pain protocol data sociodemographic health behavior clinical characteristics collected standardized way prevalence ratio pain described well factors independently associated presence pain assessed multiple logistic regression resultsa total individuals included study mostly female aged years married less eight years education steady income multivariate analysis showed symptomatic htlv sensory manifestations erectile dysfunction overactive bladder ham tsp self medication physiotherapy depression associated increased likelihood presenting pain hand physical activity religious practice associated decreased likelihood pain conclusion use self medication physiotherapy presence depression independently associated neurological symptoms htlv infected patients religious practice physical activity protective development pain sociedade brasileira infectologia published elsevier editora ltda open access article license
introductionhypothyroidism common disorder appearing mainly women although less frequently found women polycystic ovary syndrome pcos objective test hypothesis hyperandrogenism might protect hypothyroidism material methodsthe data three prospective follow studies years one register study compared women pcos rotterdam criteria women turner syndrome random population sample women men monica study findings verified rejected females region proportion hypothyroidism calculated thyroid peroxidase antibodies tpo serum measured resultshypothyroidism years age found women pcos men pcos men women turner syndrome irrespective karyotype pcos postmenopausal women population pyears women without pcos region conclusionshypothyroidism less frequently seen women pcos men compared women general population among women turner syndrome explained altered autoimmunity chromosome androgens seem protect hypothyroidism
introductionincreased exhaled nitric oxide levels asthma suggested inducible synthase inos aim study investigate expression inos bronchoalveolar lavage bal cells tissue central peripheral airways compare exhaled bronchial alveolar levels patients asthma control group methodsthirty two patients asthma defined controlled uncontrolled according asthma control test score cut eight healthy controls included exhaled measured alveolar concentration bronchial flux calculated inos measured central peripheral lung biopsies well bal cells bronchoalveolar lavage macrophages stimulated vitro inos expression production investigated resultsexpression inos increased central airway tissue alveolar compartment uncontrolled compared controlled asthmatics healthy controls differences however inos mrna levels total bal cells uncontrolled compared controlled asthma bronchoalveolar lavage cell mrna levels inos inos expression central alveolar tissue relate alveolar bronchial flux vitro stimulation leukotriene increased inos mrna levels production cultured bal macrophages conclusionthe levels bronchial alveolar inos increased uncontrolled compared controlled asthma however levels inos bal macrophages reflected alveolar central distal inos levels may reflect responsiveness steroid treatment
introductionno previous study investigated association early trauma suicidal behavior zonguldak aim study investigate incidence childhood abuse neglect general population living zonguldak province relationship childhood trauma suicidal ideations attempts methodsthe present study carried people general population assessed representative sample zonguldak province cluster sampling method used obtaining written consent people agreed participate study socio demographic information form suicide probability scale childhood trauma questionnaire beck depression inventory beck anxiety inventory administered resultsthe lifetime prevalence suicidal ideations among experienced least one type early trauma among without history childhood trauma emotional abuse exhibited significantly high odds ratio lifetime suicidal ideations odds ratio confidence interval attempts emotional neglect showed high odds ratio lifetime suicidal attempts significant correlations among beck depression inventory beck anxiety inventory suicidal probability scale sub scores six childhood trauma questionnaire scores discussionemotional abuse neglect childhood significantly associated lifetime suicidal ideations attempts general population living zonguldak province therefore clinicians aware importance childhood trauma patients suicidal ideations attempts
introductionpsoriasis multisystem immune mediated inflammatory disease authors proposed autoimmune basis psoriasis however till date definitely established study conducted explore autoimmune nature psoriasis materials methodsthis prospective study psoriasis patients assessed detailed clinical histopathological immunopathological features explore diagnostic utility subtypes intensity number immunoreactants lesional non lesional skin patients addition sera patients analyzed presence various autoantibodies resultsthe patients age ranged years male female ratio nine patients positive antinuclear antismooth muscle antibodies direct immunofluorescence dif positive biopsies lesional biopsies non lesional skin dif positive cases granular deposits detected dermoepidermal junction significant difference observed comparing type pattern immunoreactant positivity among lesional non lesional skin biopsies conclusionno significant association psoriasis immunoreactant deposition well autoantibody seroprevalence observed thereby refuting definite autoimmune basis psoriasis
introductionresults studies awareness disorders alzheimer disease controversial methodologies objects awareness patients pathologic stage vary study aimed compare scores correlates awareness according stage disease assessment method methodswe compared mild patients mild cognitive impairment mci patients using patient competency rating scale pcrs patient caregiver report self consciousness scale rating scale patients underwent cognitive psycho affective behavioral assessments global cognition executive functions episodic memory anxiety depression apathy measures resultsgroups matched age education gender comparable depression anxiety apathy awareness scales differed cognitive variables using median split approach greater apathy lower depression associated poorer awareness self consciousness scale respectively odds ratio pcrs apathy greater apathy plus lower depression associated poorer awareness scales pcrs self consciousness scale conclusionthese results evidence comparable awareness mci patients correlates affective behavioral cognitive independently assessment method
introductionthe criteria diagnosis classification myeloproliferative neoplasms mpn rely part upon assessment mutations jak mpl genes recently mutations calreticulin calr identified mpn lacking jak mpl mutations validated sensitive fragment analysis assay detect calr mutations methodsgenomic dna peripheral blood bone marrow ffpe bone marrow clot preparations mpn specimens known jak mpl mutation status non mpn specimens analyzed calr mutation testing performed fragment length analysis results confirmed sequencing accuracy precision sensitivity specificity robustness assay determined resultsforty specimens jak jak mpl jak mpl negative calr mutations twelve specimens calr mutations including deletion insertion novel deletion inframe deletion occurring allelic burden would delete three amino acids one specimen deletion also jak mutation non mpn specimens negative calr mutations assay accurately identified mutation status mpn specimens coefficient variation fragment size mutant peaks sensitivity indels conclusionsfragment analysis accurate sensitive method detection calr indels novel deletion likely germline variant consequence coexisting jak calr mutations requires careful interpretation
introductionthe aim compare contraceptive use nordic countries assess compliance recommendations european medicines agency regarding use combined oral contraception containing low dose estrogen levonorgestrel norethisterone norgestimate material methodsdata hormonal contraceptive prescriptions sales figures copper intrauterine devices obtained national databases manufacturers denmark finland iceland norway sweden resultscontraceptive use highest denmark sweden followed finland combined oral contraception used method countries highest use denmark second used method levonorgestrel releasing intrauterine system highest use finland approximate countries copper intrauterine devices progestin pill often used sweden combined oral contraception use decreased increasing age levonorgestrel releasing intrauterine system progestin pills use increased use long acting reversible methods contraception levonorgestrel releasing intrauterine system copper intrauterine devices implants increased time highest sweden finland highest use european medicines agency recommended combined oral contraception denmark increasing finland recommended combined oral contraception remained conclusionscontraceptive use highest denmark sweden levonorgestrel releasing intrauterine system use highest finland long acting methods common sweden use combined oral contraception recommended european medicines agency highest denmark
introductionthe cloninger psychobiological model temperament character includes temperamental dimensions reward dependence harm avoidance studies differentiate sensitivity reward versus punishment investigated interrelationship acutely ill patients binge purge type eating disorders eds following symptomatic stabilization methodsfifty patients eds assessed admission inpatient treatment reassessed discharge thirty six controls similarly assessed participants completed tridimensional personality questionnaire tpq sensitivity punishment sensitivity reward questionnaire spsrq took gambling task resultspatients eds higher tpq lower tpq accompanied lower spsrq spsrq spsrq correlated positively negatively tpq tpq respectively conclusionscombination lower tpq lower spsrq greater risk taking inclination may maintain disordered eating patients eds copyright john wiley sons ltd eating disorders association
introductionthere conflicting data regarding role serum ferritin surrogate parameter iron overload independent prognostic factor outcome allogeneic stem cell transplantation sct superconducting quantum interference device squid biomagnetic liver susceptometry noninvasive measurement iron overload allows measurement interference exteriorly applied small highly constant magnetic field paramagnetic liver storage iron measuring true iron load patients squid wanted assess effect iron overload patients undergoing sct methodswe conducted single center retrospective analysis comparing effect liver iron content measured squid shortly transplantation overall survival event free survival efs transplant related mortality trm patients median age range undergoing sct reduced intensity regimen patients subdivided five groups myelodysplastic syndrome novo acute myeloid leukemia aml secondary aml primary myelofibrosis others resultscorrelation squid significant significant association squid fungal infection also seen patients squid risk proven fungal infection increased fold similar association fungal infection shown univariate analysis age prognostic factor trm associated efs multivariate analysis efs age remained independent factors respectively multivariate analysis trm left age squid values final model respectively conclusionour data confirmed increases risk infection moreover fungal infection transplant recipients squid values correlate well could show indeed good surrogate parameter iron overload measured shortly sct prospective trials needed investigate effect iron chelation sct transplant outcome
introductionwe investigated prevalence rates probable ptsd used generalized estimating equations identify risk factors probable ptsd children adolescents exposed lushan earthquake methodsa total participants completed assessments including children revised impact event scale weeks months experiencing lushan earthquake additionally demographic variables variables related everyday functioning evaluated weeks earthquake via self constructed questionnaire resultsthe percentages children adolescents changed ptsd probable ptsd probable ptsd ptsd time point approximately sample respectively percentage participants without ptsd increased week month time point month month time point percentage persistent probable ptsd decreased time points respectively female gender sedentary lifestyle actively helping others significant risk factors probable ptsd whereas initiating communications others actively playing classmates friends ability concentrate academic studies resuming class factors helped protect probable ptsd discussionresistance ptsd persistent ptsd symptoms common occurrences child adolescent survivors specific variables related everyday functioning may risk factors probable ptsd findings implications agencies provide mental health services earthquake
intrusion detection playing crucial role making computer network secure transaction intrusion detection system ids detects various types malicious network traffic computer usage sometimes may detected conventional firewall recently many ids developed based machine learning techniques specifically advanced detection approaches created combining integrating evolutionary algorithms neural networks shown better detection performance general machine learning approaches present study reports two new hybrid intrusion detection methods one based gravitational search one combination particle swarm optimization gspso two techniques successfully implemented train artificial neural network ann resulting models ann gspso ann successfully applied intrusion detection process applicability proposed approaches also compared conventional methods decision tree ann based gradient descent ann ann based genetic algorithm ann ann based pso pso ann testing nsl kdd dataset moreover results obtained ann gspso ann found statistically significant based popular wilcoxon rank sum test compared conventional techniques obtained test results reported proposed ann gspso ann could achieve maximum detection accuracy respectively proposed models ann gspso ann could also achieve good performance tested highly imbalanced datasets
intrusion detection system ids one important elements providing security networks increasing number network based applications one hand increasing data volumes hand forced designers conduct research novel methods improving network security one recent efforts improve ids performance developing machine learning algorithms random forest one powerful algorithms employed data mining operates based classifier fusion principles implemented detection engine anomaly based idss paper present novel parallel random forest algorithm intrusion detection systems original random forest algorithm weaknesses feature selection selecting efficient numbers classifiers number random features training also combination steps research investigate aforementioned challenges propose solutions simulation results show superiority method regarding performance scalability cost misclassified samples method comparison original random forest algorithm hadoop based version random forest
invasive fungal diseases significant cause mortality among immunocompromised report documents unusual case disseminated fungal infection child severe aplastic anemia offending fungus basidiomycete rarely known cause human infections patient presented acutely multiple purpuric skin lesions various parts body skin biopsy revealed septated fungal hyphae embolized within small dermal blood vessels molecular sequencing indicated earliella scabrosa likely organism clinical course infection inexorable despite systemic antifungal treatment resulting mortality literature human infections due basidiomycetes usefulness histopathology early diagnosis infection possible treatment options discussed
invasive fungal infections ifi remain life threatening complications haematological patients aim study present experience single centre surgical treatment pulmonary ifi haematological patients ifi underwent pulmonary resection cases emergency procedure avoid haemoptysis lesion threatened pulmonary vessels remaining patients underwent elective surgery new chemotherapy stem cell transplantation among patients median age years range years acute leukaemia haematological first line therapy receiving induction consolidation chemotherapies invasive pulmonary aspergillosis pulmonary mucormycosis diagnosed patients respectively one patient ifi due trichoderma longibrachiatum patients received antifungal agents month preceding ifi diagnosis patients neutropenic time surgery patients still neutropenic required platelet transfusions lobectomy segmentectomy performed cases respectively mortality days post surgery respectively surgery median overall survival months median overall survival similar patients emergency elective surgery types ifi invasive pulmonary aspergillosis pulmonary mucormycosis however overall survival far better haematological first line patients achieving haematological complete response patients pulmonary ifi lung resection could effective complement medical treatment selected haematological patients chretien cmi european society clinical microbiology infectious diseases published elsevier ltd rights reserved
invasive fungal infections considerable cause morbidity mortality increased hospital stay durations high health care costs neonatal period period premature infants affected candida species leading cause invasive fungal infections majority neonatal candida infections caused albicans parapsilosis glabrata tropicalis although fungus species reported one emerging pathogen ohmeri organism reported pathogen neonatal period principally premature infants risk factors associated fungal infection central line immunosuppression prolonged hospital stay endotracheal intubation exposure antibiotics present term baby mediastinal mass required several procedures pericardiocentesis central catheters mechanical ventilation antibiotics evolution presented infection ohmeri baby treated amphotericin satisfactory clinical course
investigation paper discrete ablowitz ladik equation certain applications electrical optical systems based hirota method bilinear forms dark one two soliton solutions equation obtained soliton propagation collision graphically presented analyzed dark one soliton shown maintain original amplitude width propagation discrete peaks propagating soliton displayed overtaking collision two solitons different amplitudes observed solitons traveling direction amplitudes velocities widths unchanged head collision two solitons illustrated shapes two solitons keep invariant except phase shifts asymptotic analysis shows collision two solitons elastic society photo optical instrumentation engineers spie
investigators reported cigarette smoking associated behavioral disinhibition novelty seeking diminished threat sensitivity methods prediction smokers would obtain higher scores measures disinhibition novelty seeking behavioral activation related personality disorder symptoms lower scores measures harm avoidance behavioral inhibition associated personality disorder features tested cigarette smokers compared nonsmokers results smokers obtained significantly higher scores measures depressive symptoms novelty seeking histrionic borderline passive aggressive antisocial personality disorder symptoms lower scores measure avoidant personality groups differ measures cluster cluster personality disorder symptoms disinhibition executive dysfunction apathy harm avoidance reward dependence behavioral inhibition activation conclusions findings lend partial weak support notion smokers likely present personality features associated behavioral dyscontrol novelty seeking published elsevier ltd
ionic liquid effectively extract quinolones medicines aqueous phase order explore extraction mechanism interaction ionic liquid hexyl methylimidazolium hexafluorophosphate mim fleroxacin flx studied using fluorescence vis absorption infrared spectrometry increasing addition mim inerratic fluorescence quenching flx solution could observed fluorescence spectra stern volmer constant negative correlation temperature besides addition mirn caused decrease red shift absorption peak vis absorption spectra flx indicated fluorescence quenching flx cmim due formation mirn flx complex ground state static quenching procedure apparent affinity binding constants interaction mirn flx mol degrees respectively calculating thermodynamics parameters delta delta demonstrated extraction spontaneous process hydrophobic interaction probably major driving force extraction cmim could orderly distribute water hydrophilic imidazole ring pointing aqueous phase hydrophobic alkyl chains together arranging hydrophobic cavities hydrophobic cavities adjacent imidazole rings potential bond donor intensive electrons flx could act bond acceptor flx entered hydrophobic cavities cmirn due interaction center dot center dot center dot type bonds mim electrons included flx furthermore based infrared spectra suggested hydrophobic interaction might result flx replacing molecular combined hydrogen bonding interaction cooh groups flx
ionic polymer metal composite ipmc kind smart material used sensors actuators ipmc flexible produce larger electric signal deformed suitable used sensors measure deformation displacement flow rate however hysteresis existing ipmc deteriorate performance sensor paper neural network model based compensator proposed reduce effect hysteresis compensation scheme method expanded input space introduced transform multi valued mapping hysteresis one one mapping corresponding theory construction expanded input space illustrated based expanded input space inverse model based compensator constructed moreover geometric compensation method proposed compensate measuring error laser sensor ipmc chip finally experimental results presented validate proposed method hysteresis compensation ipmc sensors
ionic polymer metal composite ipmc used many bio inspired aquatic systems due special characteristics wet electro active polymer eap paper proposes ipmc actuator using poly vinylidene fluoride pvdf polyvinyl pyrrolidone pvp polystyrene sulfuric acid pssa blend membrane explains bio inspired walking microrobot using proposed ipmcs actuators proposed ipmc actuator fabricated using pvdf pvp pssa solution mixture ratio could generate higher tip displacement blocking force low voltages compared nafion based ipmc actuator pvdf pvp pssa based ipmc actuators employed bio inspired walking microrobot finally bio inspired terrestrial walking microrobot weight demonstrate walking motion speed coefficient friction surface
ionomeric polymer metal composites ipmcs consist ionomer bound anionic groups mobile counterions plated noble impermeable metal cover layers application electric voltage transport mobile ions towards respective electrode occurs due local electrostatic ionic forces local deformation ipmc observed therefore ipmcs promising candidates electrochemical transducers present research chemo electro mechanical behavior ipmcs described within framework theory porous media first field equations derived respect second law thermodynamics second reduced set equations chemo electric behavior formulated discretized applying finite element method numerical investigations parametric study time space dependent behavior carried order quantify influence different material compositions based study characteristic response ipmc application electric voltage predicted concluding obtained computational framework excellent tool design electrochemical transducers
irritable bowel syndrome ibs one common gastrointestinal disorders despite prevalence pathophysiology ibs well understood although multiple peripheral central factors implicated recent studies suggest role alterations gut microbiota ibs significant advances next generation sequencing technology bioinformatics declining cost allowed better investigate role gut microbiota ibs following review propose gut microbiota unifying factor pathophysiology ibs first describe gut microbiota influenced factors predisposing individuals ibs host genetics stress diet antibiotics early life experiences highlight known effects gut microbiota mechanisms implicated pathophysiology ibs including disrupted gut brain axis gba visceral hypersensitivity altered motility epithelial barrier dysfunction immune activation several gaps field preclude connecting dots establish causation hope overview allow identify fill voids
irritable bowel syndrome group symptoms includes abdominal pain changes form frequency stool since symptoms usually long lasting disease significantly degrades quality life several pharmacological therapies suggested according type symptoms abdominal pain constipation diarrhea order control abdominal pain smooth muscle antispasmodics antidepressants including tricyclic antidepressants selective serotonin reuptake inhibitors antagonists used improve constipation dietary fiber laxatives agonists chloride channel activators available opioid agonists mixed opioid agonists antagonists eluxadoline bile salt sequestrants considered diarrhea addition probiotics non absorbable oral antibiotics used normalization gut microbiome treatment small intestinal bacterial overgrowth respectively necessary understand characteristics drug combinations single regimen improve symptoms patients irritable bowel syndrome review mechanisms action efficacy adverse events associated drugs used irritable bowel syndrome summarized
nonverbal communication capable affecting economic outcomes study effect anticipated approval disapproval expressed emoticons generosity show discourages selfish behavior experiment subjects play one shot dictator game end recipient respond allocation drawing emoticon sending back dictator observed effect nonverbal communication somewhat weaker anticipation verbal response results provide evidence people willing trade pecuniary gains avoid disapproval seek approval peers sheer anticipation receiving response even nonverbal sufficient change behavior elsevier rights reserved
ischemic reperfusion contributes deleterious cardiac remodeling heart failure deacetylase sirt shown protect heart injury examined mechanism whereby injury represses sirt transcription myocardium accumulation trimethylated histone proximal sirt promoter myocardium mice following injury cultured cardiomyocytes exposed hypoxia reoxygenation accordance trimethyltransferase suvh bound sirt promoter repressed sirt transcription suvh expression regulated myocardium mice following insults treated cardiomyocytes paralleling sirt regulation silencing suvh expression suppression suvh activity erased hkme sirt promoter normalized sirt levels cardiomyocytes meanwhile suvh deficiency inhibition attenuated induced infarction improved heart function mice likely influencing ros levels sirt dependent manner therefore data uncover novel mechanism sirt trans repression cardiac injury present suvh druggable target development therapeutic strategies ischemic heart disease
ischemic stroke transient ischemic attack tia common cerebrovascular disorder leading cause death china effective secondary prevention vital strategy reducing stroke recurrence aim guideline provide updated evidence based recommendation clinical physicians prior version control risk factors intervention vascular stenosis occlusion antithrombotic therapy cardioembolism antiplatelet therapy noncardioembolic stroke recommended prevention recurrent stroke variety uncommon causes subtype provided well modified level evidence recommendation according part results domestic rct order facility clinical practice
isoflavones polyphenol compounds found mainly legumes soybeans glycine max merrill compounds found different chemical forms however beneficial effects skin care mainly credited free forms manuscript claims review main effects isoflavone aglycones skin different techniques obtaining bioactive forms soybeans interest incorporating topical systems benefits dermatological application isoflavones anti aging action estrogenic activity wound healing properties antiphotocarcinogenic effects highlighted moreover advantages drawbacks extraction techniques soybeans methods converting glucosides aglycones purification procedures described different strategies incorporate poorly soluble compounds conventional nanostructured delivery systems also discussed illustrative examples especially genistein loaded liposomes nanoemulsions nanocapsules cyclodextrin complexation reported
isoformononetin methoxylated isoflavone present medicinal plants non estrogenic bone forming effect via differential mitogen activated protein kinase mapk signaling spectroscopic raman vis nmr spectra quantum chemical calculations using density functional theory dft large basis set employed study structural electronic properties isoformononetin detailed conformational analysis performed determine stability among conformers various possibilities intramolecular hydrogen bonding formation molecular docking studies different protein kinases performed isoformononetin previously studied isoflavonoid formononetin order understand inhibitory nature effect functional groups osteogenic osteoporosis associated proteins found oxygen atoms methoxy hydroxyl groups attached phenyl rings carbonyl group attached pyran ring play major role binding protein kinases responsible osteoporosis however hydrophobic interactions observed rings ligand protein electronic properties homo lumo energies determined time dependent dft predict conformer little bit stable chemically low reactive conformer isoformononetin estimate structure activity relationship molecular electrostatic potential mep surface map reactivity descriptors calculated optimized geometry molecule results also found isoformononetin kinetically stable less toxic weak electrophile chemically less reactive formononetin atoms molecules natural bond orbital analysis applied detailed analysis intra intermolecular hydrogen bonding interactions elsevier rights reserved
isogeometric analysis iga applied heterogeneous reactor physics problems using multi group neutron diffusion equation iga uses computer aided design cad description geometry commonly built non uniform rational splines nurbs exactly represent complicated curved shapes circles cylinders common features reactor design work focused comparing iga finite element analysis fea heterogeneous reactor physics problems including oecd nea lwr benchmark exact geometry increased basis function continuity contribute accuracy iga improvement comparable fea calculations observed authors published elsevier ltd
isogeometric analysis introduced alternative finite element methods order simplify integration computer aided design cad software discretization variational problems continuum mechanics contrast finite element case basis functions isogeometric analysis often nodal consequence fat interfaces easily lead increase number interface variables decomposition parameter space subdomains building earlier work deluxe version bddc balancing domain decomposition constraints family domain decomposition algorithms several adaptive algorithms developed paper scalar elliptic problems effort decrease dimension global coarse component preconditioners numerical experiments provide evidence work successful yielding scalable quasi optimal adaptive bddc algorithms isogeometric discretizations
isolated electrical systems lack electrical interconnection networks usually placed geographically isolated areas mainly islands locations developing countries recently diesel generators able assure safe reliable supply exchange high costs fuel transportation system operation transmission system operators tsos increasingly seeking replace traditional energy models based large groups conventional generation units mixed solutions diesel groups held backup generation important advantages provided renewable energy sources grid codes determine technical requirements fulfilled generators connected electrical network regulations applied isolated grids demanding technical literature rather easy find compare grid codes interconnected electrical systems however existing literature incomplete sparse regarding isolated grids paper aims review current state isolated systems grid codes applicable specifying points comparison defining guidelines followed upcoming regulations
become axiomatic critical windows susceptibility genotoxins exist genetic damage utero may trigger later life cancers data supporting critical window hypothesis remarkably study provides quantitative bridge dna damage liver carcinogen aflatoxin afb prenatal development risk later life genetic disease afb given pregnant cbl mice carrying gestation day embryos bcf genotype ultra high performance liquid chromatography mass spectrometry uplc using aflatoxin guanine adduct standards afforded measurement afb gua afb fapy adducts post dosing liver dna mothers embryos parallel cohort gave birth livers analyzed mutations gpt gene weeks age data revealed mutational spectra dominated mutations mother offspring characteristic afb distinct background shown adducts embryos fold potent inducers mutagenesis adducts parallel dosed adults sensitivity enhancement correlated staining liver reflecting proliferative potential tissue taken together data provide insight relative genetic risks prenatal adult exposures afb early life exposure especially embryonic period strikingly mutagenic treatment later life moreover data provide baseline risk prevention strategies evaluated new genetic damage utero pave way cancer later life younger animals susceptible carcinogens adults paper authors quantify effect first time exposed fetal mice aflatoxin compared rates cancer causing mutations adult mice exposed dose aflatoxin dna adducts created fold likely cause mutations liver cells young mice adults surprisingly observed fetal liver cells dividing much faster adult liver cells providing evidence view rapid cell division creates youthful susceptibility carcinogens
shown following exposure mild perinatal adversity children greater susceptibility negative positive aspects subsequent environment large population based cohort study investigated whether mild perinatal adversity moderated association maternal harsh parenting children hair cortisol levels biomarker chronic stress mild perinatal adversity defined late preterm birth gestational age birth weeks days small gestational age birth weight percentile full term gestational age harsh parenting assessed maternal self report years children hair cortisol concentrations measured hair samples collected age significant bivariate associations mild perinatal adversities harsh parenting hair cortisol however mild perinatal adversities moderated association maternal harsh parenting hair cortisol levels children mild perinatal adversity lower cortisol levels parented harshly higher cortisol levels absence harsh parenting children experience mild perinatal adversity results provide evidence mild perinatal adversity potential marker differential susceptibility environmental influences
suggested healthy sleep facilitates consolidation newly acquired memories underlying brain plasticity authors tested hypothesis patients primary insomnia would show deficits sleep related memory consolidation compared good sleeper controls gsc study used four group parallel design investigate effects night time including polysomnographically monitored sleep sleep condition gsc versus daytime wakefulness wake condition gsc procedural mirror tracing task declarative memory consolidation visual verbal learning task demographic characteristics memory encoding differ groups baseline polysomnography revealed significantly disturbed sleep profile compared gsc sleep condition night time periods including sleep gsc associated significantly enhanced procedural declarative verbal memory consolidation compared equal periods daytime wakefulness gsc significantly enhanced procedural memory consolidation compared equal periods daytime wakefulness night time sleep across retention intervals daytime wakefulness differences experimental groups observed pattern results suggests healthy sleep fosters consolidation new memories process impaired procedural memories patients future work needed investigate impact treatment improving sleep memory
suggested isoflurane may cause perioperative liver injury however mechanism action remains unknown purpose present study determine possible mechanism sprague dawley rats randomly assigned one three groups control group exposed mock anesthesia isoflurane group exposed isoflurane min isoflurane insulin like growth factor igf group exposed isoflurane min treated igf reverse transcription quantitative polymerase chain reaction qpcr western blotting conducted determine levels expression igf receptor igf liver necrosis assessed histological examination tunel assay performed determine apoptosis hepatic cells addition levels proteins caspase cell lymphoma extra large bcl measured compared control group levels igf igf mrna protein significantly decreased following exposure isoflurane necrosis rate liver apoptosis significantly increased group treated isoflurane alone compared control group significantly decreased compared isoflurane group following application igf additionally isoflurane exposure significantly increased levels caspase compared control group decreased levels bcl contrast application igf reversed changes present study therefore suggests isoflurane induces liver injury part regulating expression igf application igf may protect liver injury induced isoflurane exposure
long known many short chain carbohydrates induce abdominal symptoms similar patients irritable bowel syndrome ibs hypothesized restricting intake short chain carbohydrates either slowly absorbed digested small intestine considered together similar effects intestine distending lumen groups carbohydrates called fermentable oligosaccharides disaccharides monosaccharides polyols fodmaps lack known collective term reducing dietary intake also hypothesized abdominal symptoms patients ibs would alleviated patients visceral sensitivity low fodmap diet subsequently designed last years mechanisms action food content fodmaps efficacy diet among aspects intensively studied many parts world low fodmap diet considered front line therapy ibs
common goal improve safety performance mobile indoor robots predicting movements people surroundings contrast many related works exclusively employ sensors mounted mobile robots work shows method achieve goal smart environment external sensors used sense people positions using probabilistic models filters evolution environment state predicted optimal paths respect safety performance planned experiments reality simulation environment show applicability real world scenarios advantages classical path planning approaches
currently unknown whether speech limb motor effectors parkinson disease controlled similar underlying brain processes based computerized objective analysis aim study evaluate potential correlation speech mechanical tests upper limb motor function speech upper limb motor tests performed patients healthy controls quantitative acoustic analyses eight key speech dimensions hypokinetic dysarthria including quality voice sequential motion rates consonant articulation vowel articulation average loudness loudness variability pitch variability number pauses performed upper limb movements assessed using motor part unified parkinson disease rating scale contactless three dimensional motion capture system blinded expert evaluation purdue pegboard test significant relationships observed quality voice assessed jitter amplitude decrement finger tapping consonant articulation evaluated using voice onset time expert rating finger tapping number pauses purdue pegboard test score current study supports hypothesis speech impairment shares least partially similar pathophysiological processes limb motor dysfunction vocal fold vibration irregularities appeared influenced mechanisms similar amplitude decrement repetitive limb movements consonant articulation deficits associated decreased manual dexterity movement speed likely reflecting fine motor control involvement
difficult extend grayscale morphological approach color images total vector ordering required color pixels address issue developed kind vector ordering method based linear transformations rgb color spaces yuv yiq ycbcr principal component analysis pca additionally propose conditionally invariant morphological framework based proposed vector ordering also define elementary multivariate morphological operators multivariate erosion dilation opening closing investigate properties focus duality proposed framework guarantees important properties classical mathematical morphology translation invariance conditional increasingness duality therefore easy extend existing grayscale morphological approaches color images terms proposed multivariate morphological framework mmf simulation results show potential abilities mmf color image processing image filtering reconstruction segmentation elsevier inc rights reserved
estimated million children ages years participated organized youth football united states approximately children play football nation largest youth football organization tackle divisions starting age years number children playing unsupervised football much higher overall number children participating american football increasing sports leading cause injury related emergency room visits teenagers football leading precipitating athletic activity visits football also hazardous organized sports united states though pediatric football related injuries minor abrasions sprains strains extremities football accounts major catastrophic injuries sport given football popularity children united states combined high rate injury associated participation activity radiologists familiar imaging features injury patterns seen patient population
hypothesized excess weight risk factor delayed recovery neck pain whiplash injuries however association obesity recovery whiplash injury studied authors examined association body mass index time recovery whiplash injuries population based cohort study traffic injuries saskatchewan canada cohort included individuals made insurance claim saskatchewan government insurance treated whiplash injury july december recovered november association found baseline body mass index time recovery compared individuals normal weight underweight hazard rate ratio confidence interval overweight hazard rate ratio confidence interval obese hazard rate ratio confidence interval similar rates recovery even adjustment factors results support hypothesis individuals overweight obese worse prognosis whiplash
important determine mechanical properties reinforced soils since extensively used practice study laboratory triaxial tests direct shear tests carried order determine stress strain dilation characteristics geotextile reinforced river sand mechanical behaviour composite material investigated varying type geotextile confining pressure interface properties geotextile reinforced samples evaluated direct shear tests results demonstrated geotextile inclusion increases peak strength reduces dilation especially higher confining pressures
known constant power load connected electrical network may lead instability problems link variables paper addresses problem instability supercapacitor energy storage element connected network used stabilize achieve goal nonlinear control law based backstepping approach synthesised robustness tests relatively parameters variation realized simulation results confirm good performances robustness using approach
known children mental developmental problems risk abuse neglect attention deficit hyperactivity disorder one frequent neurodevelopmental disorders children adolescents purpose study examine whether children diagnosed adhd risk terms child abuse neglect compared controls case control study children applied child adolescent psychiatry unit bursa yuksek ihtisas training research hospital january june diagnosed adhd psychiatric comorbidity except disruptive behavior disorders healthy children compared abuse assessment questionnaire applied children approval families received determined children diagnosed adhd exposed physical emotional abuse statistically significant way compared controls exposed physical emotional neglect lower rate compared healthy children difference healthy children terms witnessing family violence exposed sexual abuse children diagnosed adhd exposed physical emotional abuse higher rate studies emphasize role parents topic parental education treatment programs change results elsevier ltd rights reserved
known new religious movements nrms accepted various segments society arising different beliefs rituals different lifestyles different values emerged periods normative gender roles questioned thus women rights movement occurred mid nineteenth century struggled order women achieved civil political rights contributed directly indirectly emergence nrms additionally fact nrms promoted women rights social reforms even offered leadership opportunity attracted women suffered oppression placed secondary positions paper focuses relationship new religious movements women examined basic matters effect gender participation nrms status roles women men nrms issue women leadership whether women abused nrms
well established sgc cgmp signal transduction system mediates many different physiological functions almost every conceivable organ system best characterized cardiovascular system driven cgmp production exerts plethora cytoprotective anti atherogenic effects including dilatation inhibition vascular smooth muscle proliferation blockade leukocyte recruitment anti platelet activity accordingly dysfunctional sgc cgmp mediated signaling perceived underlying pathophysiological cause many cardiovascular non cardiovascular diseases due fundamental role sgc signaling pathways triggered novel sgc modulators identified directly stimulate heme containing well heme free sgc called sgc activators sgc stimulators respectively beneficial effects new family sgc modulators extend beyond vasodilation potential cardiovascular diseases aside pulmonary arterial hypertension promising animal models hypertension heart failure reno protective effects attenuated cardiac fibrosis attenuated hypertrophy independent hemodynamic effects shown recent years become obvious cgmp increase sgc modulators exerts direct antifibrotic efficacy various organs well skin review provide overview preclinical vitro vivo studies different fibrotic disorders including chronic renal cardiac liver lung fibrosis well sclerosis wound healing moreover review provides evidence new mode action sgc modulators implication clinical investigations treatment fibrotic disorders pulmonary fibrosis skin fibrosis published elsevier ltd
quite challenge remember privately store key encrypting secret image moreover encrypted image may arouse invaders suspicion paper novel secret image sharing scheme additional steganography repairable capabilities proposed using bit plane compression lagrange interpolation formula proposal suggests user select ostensible image example famous character image cover image camouflage secret image enhance security specifically protected image divided three shares hidden cover image create meaningful shadow images three shadow images distributed three different devices example smartphone laptop cloud storage collecting two shadow images user losslessly retrieve original secret image cover image addition proposed scheme easily repairable smartphone laptop lost system analysis shows proposal achieves theoretical information security also technically practical
shown newton second law conservation linear momentum arbitrary types force full formula force used second law effective exerting observable ponderomotive action test element force exerting element infinitely massive otherwise immobilized inertial system preclude recoil realistic case finite mass force exerting element free recoil mutual action reaction recoil motion steals energy observable force action physically effective force exerted test element mass represented product formula force inertial modulation factor omega less equal application elementary result classical electrodynamics shows invalidate physics many theorems universally taken granted since nineteenth century instance well established mathematical theorem closed current loop external straight current carrying test element necessarily exerts zero longitudinal ponderomotive force latter lorentz force law original ampere force law others differing additive exact differential quantity need valid physically reason inertial factor omega overlooked presence extra factor green function multiplying force differential spoil exact differential nature loop integrand instance external loop physically configured weak link namely unanchored section conductor relatively low mass much less high mobility freedom recoil along portion circuit omega approximate whereas remainder circuit anchored laboratory omega approximate hence integral around whole circuit treats low mass portion circuit much open gap despite presence current proposition easily put observational test using electromagnetically driven tuning fork bearing straight segments current carrying conductor sensor test element arranged respond longitudinal force confirmed observed alteration fork resonance response excitation suitably configured weak link external closed electrical circuit indeed cause readily detectable violation closed loop longitudinal force theorem sum exhibited cross talk electromagnetic inertial properties conducting circuits limit applicability many classical electrodynamic theorems concerning closed loops theorems assuredly valid special case completely immobilized force exerting circuits circuits parts constrained prescribed states motion free recoil ability violate classical theorems century made empirical choices among candidate force laws impossible implies experiments designed allow choices made unambiguously
common model industrial sub process transfer function fopdt topdt models also found situations appropriate model third order transfer function composed three first order processes series delay function composes topdt scanty information available controller tuning techniques topdt process present analysis starting topdt model converting sopdt fopdt controllers designed using integral error based tuning techniques controllers analyzed set point tracking capacity
well established maintenance energy expenditure linked active hypothalamic neural mechanisms controlling adaptive stimuli food intake variations glucose levels hormonal leptin plus orexin parameters involved energy homeostasis different behavioral states yet fully defined first study behavioral analyses unpredictable stress model dealing actions sub chronic administration orexin orx anti hunger neuropeptide leptin lep within hypothalamic suprachiasmatic sch nucleus conducted valuable hibernating rodent hamster mesocricetus auratus model noted distinct depression anxiety states treatment lep accounted notable reduction body weight stressed hamsters executed evident movements elevated plus maze epm also spent less time dark area light dark box test ldt conversely orx predominantly evoked anxiogenic effects inverted lep interestingly anti hunger neuropeptide accounted regulated npy transcripts mostly lateral posterior hypothalamic areas regulated levels detected parietal cerebral cortex hippocampus amygdala largely behaved opposite manner orx dependent effects overall present findings corroborate predominating lepergic effect sch toward reduction hamster anxiety like behaviors respect orx signaling may constitute useful therapeutic targets stress related obesity states
well established transpiration photosynthetic rates generally increase resprouting shoots fire chaparral shrublands contrast little known plant hydraulic function varies recovery period hypothesized vascular traits functional structural would also shift order support heightened level gas exchange growth examined stem xylem specific hydraulic conductivity resistance cavitation eight chaparral shrub species well several potential xylem structural determinants hydraulic function compared established unburned plants occurring post fire resprouting plants unburned plants generally resistant cavitation resprouting plants two groups differ resprouting plants altered vessel structure compared unburned plants resprouting plants wider diameter vessels higher inter vessel pit density biomechanics unburned plants stronger denser stem xylem tissue resprouting plants shifts hydraulic structure function resulted resprouting plants vulnerable dehydration interaction time since disturbance resprouting versus established stands drought may complicate attempts predict mortality risk resprouting plants well established transpiration photosynthetic rates generally increase resprouting plants fire chaparral shrublands little known plant hydraulic function varies recovery period ecophysiology eight species chaparral shrubs compared resprouting plants adjacent unburned plants resprouting plants varied unburned plants hydraulics xylem structure biomechanics observed shifts resulted resprouting plants vulnerable dehydration unburned plants demonstrate potential variability plants hydraulic physiology depending disturbance recovery state
well known beta adrenoceptors beta ars play critical role emotional arousal stressful events specific contributions beta subtype psychological disorders largely unknown investigate whether beta involved anxiety like behavior reward addictive drugs conducted series behavioral tests beta knock mice beta mice exhibited increased preference dark compartment closed arm tests light dark box elevated plus maze indicating beta deletion elevates level anxiety innate fear beta mice also showed decreased immobility tail suspension test tst suggesting beta deletion inhibits depression like behavior interestingly beta ablation change basal locomotion significantly increased locomotor activity induced acute cocaine administration beta mice showed enhanced place preference cocaine could attenuated selective antagonist betaxolol consistently beta agonist suppressed cocaine conditioned place preference cpp data indicate beta deletion enhances acute response reward cocaine results suggest beta regulates anxiety level depression like behavior hedonic properties cocaine implicating beta potential targets treatment emotional disorders cocaine addiction
well known operating condition metallic structural system dynamic crack growth speed order industrial finishes like coating form integral part manufacturing adopted improve fracture toughness metals coated samples coated thin films mechanically tested charpy notch impact tester estimating dynamic fracture toughness coatings improve wear corrosion resistance materials tend reduce strength materials increased residual stresses due coating process defects precluded coated treated components strength components presence defects analyzed fracture mechanics approach attempt made analyze effectiveness coating methods like electroplating pvd physical vapour deposition coating thickness service temperature fracture behaviour metals experiments carried ens steel aluminium different temperatures later samples corroded tested corrosion resistance specimen preparation experimentations carried according astm standard finite element analysis done franc fracture analysis code estimating stress intensity factor different crack lengths along influence temperature corrosion pvd coated samples aluminium nitride nano crystalline layer titanium aluminium nitride showed improved dynamic fracture toughness properties set samples showed decrease stress intensity factors excellent corrosion resistance compared conventional nickel chromium coated samples mechanical behaviour selected metals heat affected zone also discussed paper study aims coated uncoated cases performances metals cryogenic condition also paid attention paper crown copyright published elsevier ltd rights reserved
well known kidney plays important role development cardiovascular diseases hypertension normal aging process leads changes kidney morphology hemodynamics function increase incidence cardiovascular events elderly population disturbances influenced several factors including gender general females protected effects estrogens cardiorenal system several studies demonstrated beneficial effects estrogens renal function elderly however relationships androgens kidney health one lifetime well understood sex steroids many complex actions decline levels aging clearly influences kidney function decreases renal reserve facilitates development cardiovascular disorders therefore review discuss cellular biochemical molecular mechanisms sex hormones may influence renal function aging process
well understood biopharmaceutical industry must improve efficiency along path laboratory concept commercial product vivo imaging recognized useful method provide biomarkers target engagement treatment response safety mechanism action imaging biomarkers potential inform selection drugs likely safe effective imaging modalities biopharmaceutical research translatable clinic vivo imaging require removal tissue provide biomarkers thus reducing number valuable preclinical subjects required study longitudinal imaging allows quantitative intra subject comparisons enhancing statistical power reducing number subjects needed evaluation treatment effects animal models noninvasive nature vivo imaging also provides valuable approach alleviate minimize potential pain suffering distress
widely argued parenting intensified recent decades family life become increasingly child centred intensive parenting represents cultural shift parenting behaviour requires enactment individual level moreover adherence intensive parenting standards often presented conscious willing adoption whereby parents choose parent particular way article explores parents conform intensive parenting ideals data drawn depth interviews parents sydney australia reflected differences children childhood article argues parents conform intensive parenting standards least partly social context curtails ability otherwise failure uphold intensive parenting ideals associated several perceived risks parents children
may important know impressions someone differ person sees others see person investigated whether people aware friends see knowledge identity seen others knowledge reputation previous research indicates physical attractiveness romantic partners knowledge others perceptions unknown whether people platonic relationships also detect discrepancies perceptions others examined phenomenon new set characteristics big five personality traits primary research questions pertained identity accuracy reputation accuracy knowledge target self views others view target respectively identity insight reputation insight identity accuracy reputation accuracy accounted potential artifact perceivers assuming others share views targets however series preliminary tests examine reputation insight several necessary conditions met indicating effects would likely spurious find perceivers accurately infer target identity reputation global personality traits identity reputation accuracy perceivers sometimes accurately distinguish perceptions targets targets self views others views targets identity reputation insight finally explored boundary conditions knowledge others perceptions whether knowledge identity correlated knowledge reputation
noticed long ago sleep disorders interruptions normal sleep pattern associated various gastrointestinal disorders review studies established causal link disorders sleep impairment however mechanism interactions quality sleep gastrointestinal pathophysiology remained unclear recently visceral theory sleep formulated theory proposes brain structures particularly cortical sensory areas wakefulness involved processing exteroceptive information switch sleep processing information coming various visceral systems review studies demonstrated neurons various cortical areas occipital parietal frontal sleep began fire response activation coming stomach small intestine data demonstrate sleep computational power central nervous system including cortical areas engaged restoration visceral systems thus general mechanism interaction quality sleep health became clear
joint attention shared focus attention objects events social partner crucial milestone development social communication notable area deficit children autism spectrum disorder valid parent report screening measures social communication available majority measures designed assess wide range behaviors targeted assessment joint attention related skills primarily limited semi structured examiner led interactions time consuming laborious score pictorial infant communication scale efficient parent report measure joint attention used complement structured assessments fully characterizing early social communication development study examined psychometric properties pictorial infant communication scale results revealed high degree internal consistency strong intercorrelations subscales additionally confirmatory factor analysis supported three factor model joint attention furthermore significant correlations pictorial infant communication scale direct clinical measures child joint attention language skills autism spectrum disorder symptom severity suggestive concurrent validity findings suggest pictorial infant communication scale promising tool measuring joint attention skills preschool aged children autism spectrum disorder
joint gaze behavior plays crucial role nonverbal communication enhances group interactions recently reported conditions uncertainty observers assume another person left right averted gaze directed towards prior direct gaze given people gaze deviate many directions social interactions developed versatile method examine influence prior direct gaze varies across range gaze directions forward facing rotated heads find observers tend report another gaze along axes direct uncertainty introduced adding noise stimulus also find influence prior stronger rotated heads direct forward heads consistent idea uncertain humans tend judge gaze deviations directed regardless head rotation axis deviation
joint homeostasis failure result osteoarthritis currently treatments alter disease progression targeting early changes cellular behavior great potential recent data show nuclear receptors contribute pathogenesis could viable therapeutic targets molecular mechanisms cartilage incompletely understood study examines global changes gene expression treatment agonists four nuclear receptor implicated lxr ppar delta ppar gamma rxr murine articular chondrocytes treated agonists lxr ppar delta ppar gamma rxr underwent microarray qpcr cellular lipid analyses evaluate changes gene expression lipid profile immunohistochemistry conducted compare two differentially expressed targets txnip gsta control cartilage specific ppar delta knockout mice subjected surgical destabilization medial meniscus dmm nuclear receptor agonists induced different gene expression profiles many responses affecting lipid metabolism lxr activation downregulated gene expression proteases involved whereas rxr agonism decreased expression ecm components increased expression mmp functional assays indicate increases cell triglyceride accumulation ppar gamma lxr rxr agonism decrease ppar delta agonism ppar delta rxr downregulate antioxidant gsta ppar delta upregulates txnip wild type ppar delta deficient mice display increased staining txnip dmm collectively data demonstrate nuclear receptor activation chondrocytes primarily affects lipid metabolism case ppar delta change might lead increased oxidative stress possibly contributing associated changes
joint sparse representation jsr shown great potential various image processing computer vision tasks nevertheless conventional jsr fragile outliers paper propose weighted jsr wjsr model simultaneously encode set data samples drawn subspace corrupted noise liers model desirable exploit common information shared data samples reducing influence outliers solve wjsr model introduce greedy algorithm called weighted simultaneous orthogonal matching pursuit efficiently approximate global optimal solution apply wjsr mixed noise removal jointly coding grouped nonlocal similar image patches denoising performance improved incorporating global prior sparse errors unified framework experimental results show denoising method superior several state art mixed noise removal methods
official launch dsm research domain criteria rdoc initiative national institute mental health made public becoming increasingly important psychiatric research aim paper clarify conceptual approach rdoc systematically discuss limitations present exemplary rdoc based studies consider relevance rdoc concepts clinicians scientists qualitative introduction review article critical discussion rdoc initiative conceived alternative diagnostic manual dsm idc use clinical practice new systematic framework psychiatric research based recent results cognitive neuroscience aims map mental disorders dimensionally transdiagnostically despite weaknesses currently elaborated scientifically grounded approach multidisciplinary research mental disorders contrast purely symptom based dsm icd approaches agnostic respect pathogenesis mental diseases explicit aim rdoc initiative systematize biological knowledge risk factors causes mental disorders therefore much greater potential develop new individualized therapeutic strategies based disease mechanisms
juvenile offenders may young manage terms probation independently parent participation probationary process critical youths successful transition crime desistence however parent capacity support child legal process may depend parent knowledge justice system operates present study first quantify mothers knowledge juvenile justice system authors examine association mothers legal knowledge legal participation youth offending using longitudinal sample dyads total mothers sons first time juvenile offenders results indicate mothers averaged test legal knowledge importantly mothers knew least system also participated least son legal process mothers participated least sons self reported offending within first year arrest practitioners encouraged educate parents juvenile offenders rights responsibilities courtroom probation create meaningful avenues parental involvement set youth success first arrest
kamstra offer seasonal affective disorder hypothesis explain variations daily returns stock indices examine kamstra new variable called sad onset recovery analysis reveals concerns validity sad hypothesis elsevier inc rights reserved
kelly coast eng present finite volume dynamic adaptive mesh model based osher approximate riemann solver prediction storm surges complex landscapes model described paper extended use distributed memory parallel block tree based mesh refinement via paramesh library resulting model called fully adaptive storm tide fast model thus run massively parallel supercomputers paper validate fast model conducting numerical simulations storm surges due hurricanes wilma lake okeechobee ike gulf mexico storm surge due wilma lake okeechobee interesting considered almost idealized case comprises closed system case hurricane ike complex involves coastline additional features barrier islands tidally controlled boundaries cases results obtained using fast model compare favorably measured water elevation high water mark data moreover show sufficient computational resource low runtimes possible real world surge simulations fast model therefore potential run ensemble predictions necessary account variability inherent hurricane forecasting
keratin marker basal progenitor cells epithelia number organs prenatal development submandibular gland smg mice progenitor cells developing epithelia play important roles organogenesis although cells also present adult mouse smg may function tissue regeneration histological localization yet investigated detail present study examined immunohistochemical localization smg adult postnatal developing mice birth immunoreactivity detected entire duct system localized basal cells double layered epithelium detected terminal tubule myoepithelial cells postnatal weeks development intercalated ducts striated ducts excretory ducts immunoreactive basal cells gradually restricted proximal double layered portions connecting time immunoreactivity appeared myoepithelial cells positive ratio gradually increased adults immunoreactivity localized myoepithelial cells basal cells small number cells boundary female smg granular convoluted tubules male smg results suggest marker differentiated myoepithelial cells duct progenitor cells mouse smg
key encapsulation mechanism kem important key distribution mechanism allows sender receiver safely share random session key also mainly applied construct hybrid public key encryption scheme paper give positive answer question possible build efficient kem lattices precisely wedesign efficientkemscheme standard model based ideal lattices prove proposed scheme captures indistinguishability active chosen ciphertext attacks ind cca ring learning errors problem formally ind cca security compared current cca secure kem schemes based lattices standard model scheme shorter public key secret key encapsulation ciphertext addition kem scheme realizes ind cca security standard model
keyword search relational databases widely studied exploration structured data userfriendly way however users typically limited domain knowledge unable precisely specify search intention existing methods find minimal units contain query keywords largely ignore interpretation possible users search intentions result users often overwhelmed lot irrelevant answers moreover without visually pleasing way present answers users often difficulty understanding answers complex structures therefore design interactive yet visually pleasing search paradigm called expressq expressq extends keyword query language include keywords match meta data names relations attributes keywords utilized infer users search intention possible search intention represented query pattern whose meaning described human natural language series user interactions expressq determine search intention user translate corresponding query patterns sqls retrieve answers query expressq prototype available http expressq comp nus edu
knowledge spatial temporal patterns beta amyloid beta accumulation essential understanding alzheimer disease design antiamyloid drug trials tested whether regional pattern longitudinal beta accumulation predicted baseline amyloid pet methods baseline followup florbetapir pet data patients incipient manifest dementia due analyzed determination fast amyloid deposits given region relative whole brain gray matter pseudotemporal accumulation rate region calculated actual accumulation rate florbetapir calculated follow data results pseudotemporal measurements baseline pet data explained variance longitudinal accumulation rate across regions method accurately predicted top fast slow accumulating regions conclusion pseudotemporal analysis baseline pet images capable predicting regional pattern longitudinal beta accumulation group level approach may useful exploring spatial patterns beta accumulation amyloidassociated disorders lewy body disease atypical forms addition method allows identification brain regions high accumulation rate beta particular interest antiamyloid clinical trials
korteweg vries kdv type equations used approximate models governing weakly nonlinear long waves fluids first order nonlinear dispersive terms retained balance retained second order terms result extended fifth order kdv equation darboux transformation multi soliton solutions extended fifth order kdv equation coefficient constraints constructed soliton propagation properties interactions studied except velocity amplitude width soliton influenced coefficient original equation amplitude velocity wave shape soltion remain unchanged interaction virtue generalised taylor expansion solutions corresponding lax pair first second order rational solutions equation obtained
dihydroxyphenylalanine dopa remains effective drug therapy parkinson disease however long term use causes serious side effects dopa induced dyskinesia lid consistently related dopa derived excessive dopamine release mechanisms addressed clear monoamine oxidase mao one key enzymes dopamine metabolism therefore may involved dopa induced side effects epigenetic modification controls mao gene transcription investigate effects dopa mao transcription underlying epigenetic mechanism neuronal syy cells treated dopa acute days chronic results showed chronic dopa administration resulted dose dependent time dependent downregulation mao whereas acute dopa administration induced upregulation mao transcription expression meanwhile chronic dopa exposure induced cpg hypermethylation mao promoter acute dopa administration caused cpg hypomethylation cpg demethylation resulted reactivation mao transcription results indicated aberrant cpg methylation might play key role mao transcriptional misregulation dopa administration addition results showed acute dopa administration induced downregulation dna methyltransferase dnmta transcription ten eleven translocation tet significantly downregulated chronic dopa administration data indicated chronic dopa administration tet downregulation might mediate cpg hypermethylation responsible downregulation mao transcription contrast acute dopa administration dnmta downregulation might mediate hypomethylation contributing mao upregulation conclusion findings suggested tet dnmts might mediate aberrant cpg methylation associated misregulation mao dopa administration might contribute dopamine release abnormally leading side effects dopa
labor productivity fundamental building block planning controlling construction therefore predicting labor productivity levels given condition important construction management however predicting labor productivity extremely difficult due large number factors affect productivity perplexing ways another obstacle predicting labor productivity qualitative nature subjectivity productivity factors address issues soft computing technique called fuzzy cognitive maps fcms proposed tool model complex inter relationships productivity factors based expert knowledge assessing impact productivity factors labor productivity paper methodology creating using fcms purpose introduced exercise presented demonstration purposes additionally issues identified exercise described way fcms practically used field predicting labor productivity also discussed paper
lambda calculus represent programs closed normal forms turn closed normal forms data structures sense internal structure accessible queries defined calculus even point constructing goedel number program thus program analysis optimisation performed entirely within calculus without requiring meta level process quotation produce data structure lambda calculus confluent applicative rewriting system derived lambda calculus combinatory calculus superior expressive power relative lambda calculus demonstrated ability decide two programs syntactically equal determine program uses input indeed homomorphism applicative rewriting systems lambda calculus lambda calculus program analysis optimisation illustrated considering conversion programs combinators traditionally program interpreted using fixpoint constructions normal forms combinatory techniques used block reduction program arguments given interpreted closed normal form factorisation adapts traditional account lambda abstraction combinatory logic convert combinator equivalent following two senses first extensionally equivalent extensional equivalence defined terms eta reduction second conversion intensional equivalence lose information reversed another definable conversion standard optimisations conversion process definable within lambda calculus even involving free variable analysis proofs theorems paper verified using coq theorem prover
land degradation affects large areas land around globe grave consequences living land major efforts made implement soil water conservation measures counteract soil erosion help secure vital ecosystem services however extent measures implemented often well documented knowledge could help identify areas soil water conservation measures successfully supporting sustainable land management well areas requiring urgent rehabilitation conservation structures terraces bunds study explores potential latest satellite based remote sensing technology use assessing monitoring extent existing soil water conservation structures used set high resolution stereo geoeye satellite data derived detailed digital surface model well set spectral terrain texture filtered information layers developed applied object based classification approach working two segmentation levels coarser level aim delimit certain landscape zones information landscape zones useful distinguishing different types soil water conservation structures zone contains certain specific types structures finer level goal extract identify different types linear soil water conservation structures classification rules based mainly spectral textural shape topographic properties included object relationships approach enabled identify separate classes majority terraces bunds well hillside terraces omission commission errors similar obtained existing studies focusing research objective using different types remotely sensed data based results estimate construction conservation structures study area eritrea required person days work underlines huge efforts involved soil water conservation elsevier ltd rights reserved
land use land cover important determinant ecohydrologic processes watershed systems continued urbanization changes nature ecohydrological regimes watersheds increases vulnerability flooding soil loss water pollution integrate hydrologic risk suitability analysis land use decisions used ecohydrologic risk criteria land use impacts water quality quantity riva creek watershed located east istanbul turkey hydrological risks modeled sub watershed using spatial analysis spatial quantitative assessment used rank sub factors evaluating suitability agricultural residential forest operations expert focus group used quantify weights results revealed watershed prone hydrologic risk medium severe levels concluded ecohydrological evaluations form background landscape assessments watersheds integrated approach spatial results provide basis long term planning elsevier rights reserved
landfill leachate makes potential source ground water pollution municipal waste landfill substratum used removal pollutants leachate model research performed use sand bed artificially prepared leachates effectiveness filtration bed specific thickness assessed based total solids content result model research indicated mass pollutants contained leachate filtered layer porous soil depends mass pollutants supplied determined regression functions indicate agreement empirical values variable determined regression functions allow qualitative quantitative assessment influence analysed independent variables omega values mass pollutants flowing medium sand layer results research used forecast level pollution soil underground waters lying zone potential impact municipal waste landfill
landslides significant pervasive impacts life property around world several attempts made predict geographic distribution landslide activity continental global scales efforts shared common traits resolution modeling approach explanatory variables lessons learned prior research applied build new global susceptibility map existing previously unavailable data data slope faults geology forest loss road networks combined using heuristic fuzzy approach map evaluated global landslide catalog developed national aeronautics space administration well several local landslide inventories comparisons similar susceptibility maps suggest subjective methods commonly used scale part reproducible however comparisons landslide susceptibility across spatial scales must take account susceptibility local subset relative larger study area new global landslide susceptibility map intended use disaster planning situational awareness incorporation global decision support systems
land use change important determining assessing influence human activity aquatic environment rivers lakes present work bosten river basin subject analyzes features dynamic land use change basin order study influence ofland use pattern change basin water quality according land use land cover lucc chart made arcgis shows cultivated land wetland forestland constitute bosten river basin taking total lucc basin relatively small increase cultivated land residential industry land water wetlands transformed forestland grassland unused land lucc basin relatively significant continuing bigger increase cultivated land residential industry area transformed water wetlands unused land based analysis land use pattern water quality index told water pollution positively correlated cultivated land residential industry area negatively con elated water grassland also influence land use pattern change water quality discussed whose finding serve scientific evidence land use optimization water pollution control
laquinimod currently tested therapeutic drug multiple sclerosis however exact mechanism action still investigation tracking fluorescently tagged encephalitogenic cells experimental autoimmune encephalomyelitis eae animal model multiple sclerosis revealed laquinimod significantly reduces invasion pathogenic effector cells cns tissue cell activation differentiation amplification within secondary lymphoid organs immunization myelin antigen migratory capacity activation within nervous tissue either mildly affected remained unchanged instead laquinimod directly impacted functionality cns vasculature expression tight junction proteins human brain endothelial cells regulated upon laquinimod treatment resulting significant increase transendothelial electrical resistance confluent monolayers brain endothelial cells similarly expression adhesion molecule activated leukocyte cell adhesion molecule alcam inflammatory chemokines ccl suppressed leading significant reduction migration memory lymphocytes across blood brain barrier bbb data indicate laquinimod exerts therapeutic effects tightening bbb limiting parenchymal invasion effector cells thereby reducing cns damage elsevier inc rights reserved
large artery atherosclerotic stroke las shows substantial heritability explained previous genome wide association studies explore role coding variation las analyzing variants humanexome beadchip total cases controls europe australia south asia report nonsynonymous single nucleotide variant serpin family member serpina encoding alpha antitrypsin aat odds ratio confirm histone deacetylase hdac major risk gene las association utr using quantitative microscale thermophoresis show exhibits almost twofold lower dissociation constant primary target human neutrophil elastase lipoprotein containing plasma lipid free plasma hydrogen deuterium exchange combined mass spectrometry revealed significant difference global flexibility two variants observed stronger interaction lipoproteins plasma reduced global flexibility val variant likely improve local availability reduce extent proteolytic inactivation proteases atherosclerotic plaques results indicate interplay aat lipoprotein particles modulated gate region around position aat far away unaltered reactive center loop collectively findings point functionally relevant balance lipoproteins proteases aat atherosclerosis
large electric dispersal barriers constructed chicago sanitary ship canal cssc prevent transfer invasive fish species mississippi river basin great lakes basin simultaneously allowing passage commercial barge traffic investigated potential entrainment retention transport freely swimming fish within large gaps created junction points barges modified mark capture trials employed assess fish entrainment retention transport barge tows multi beam sonar system enabled estimation fish abundance within barge junction gaps barges also instrumented acoustic doppler velocity meters map velocity distribution water surrounding barge gap formed junction two barges results indicate water inside gap move upstream barge tow speeds near barge tow travel speed water within side barge junction gaps observed move upstream barge tow observed transverse vertical water velocities suggest pathways fish may potentially entrained barge junction gaps results mark capture trials provide direct evidence small fish become entrained barges retained within junction gaps transported distances least fish entrained within barge junction gap retained space barge tow transited locks electric dispersal barriers would expected impede fish movement upstream published elsevier behalf international association great lakes research
large multicenter acute stroke trials demand randomization procedure high level treatment allocation randomness effective control overall within site imbalances minimized time delay study treatment caused randomization procedure driven randomization algorithm design study efficacy safety activase alteplase patients mild stroke prisms nct paper compares operational statistical properties different randomization algorithms local central step forward randomization settings results show step forward randomization block urn design provides better performances others concern potential time delay serious central randomization system available minimization method imbalance control threshold biased coin probability could better choice elsevier inc rights reserved
large scale multi label learning problem determining associated set labels instance gaining relevance recent years due emergence several real world applications notably exponential growth socialweb resource labeled millions users using one tags resource associated several labels time well known approach multi label classification binary relevance algorithm trains binary classifier label independently however serial implementation suitable medium large datasets due time computational resources required training example training classifiers mid size datasets using mulan implementation might take several weeks paper discusses parallel implementation mulan technique harnesses computational power nowadays multi core processors implementation presents speed training phase times compared original mulan implementation addition cross validation technique mulan huge ram requirements making unusable large datasets therefore overcome limitation using compact data structures taking advantage disk caching also compared implementation scikit learn popular tool data mining data analysis showing significant improvements speed
large multi institutional groups collaborations scientists engaged nuclear physics research projects number research facilities dwindling collaborations authorship rules produce large number highly cited papers multiple authorship nuclear physics publications creates problem assessment individual author productivity relative colleagues renders ineffective performance metrics solely based annual publication citation counts many institutions increasingly relying total number first author papers however approach becomes counterproductive large research collaborations alphabetical order authors concept fractional authorship claiming credit authorship one individual helps clarify issue providing complete picture research activities present work nuclear physics fractional total authorships investigated using nuclear data mining techniques historic total fractional authorship averages extracted nuclear science references database current range fractional contributions deduced results study implications discussed conclusions presented
large array resistive sensors found variety applications industrial instrumentation medical wearable applications large array sensors several non idealities limit accuracy readout circuit paper analyzing crosstalk error caused input offset voltage input bias current operational amplifier novel double sampling technique proposed considerably reduce error spice simulation results array confirm omega resistance proposed technique decrease maximum measureable relative error furthermore measurement results array confirm resistance value omega measured proposed technique reduce error
large scale computing technologies enabled high throughput virtual screening involving thousands millions drug candidates trivial however biochemical scientists evaluate technical alternatives implications running large experiments besides experience molecular docking tool scientist needs learn run high performance computing hpc infrastructures understand impact choices made review considerations specific tool autodock vina use experimental data illustrate following points additional level parallelization increases virtual screening throughput multi core machine capturing random seed enough though necessary reproducibility heterogeneous distributed computing systems overall time spent screening ligand library improved analysis factors affecting execution time per ligand including number active torsions heavy atoms exhaustiveness also illustrate differences among four common hpc infrastructures grid hadoop small cluster multi core virtual machine cloud analysis shows platforms suitable screening experiments different sizes considerations guide scientists choosing best computing platform set future large virtual screening experiments
laser scanning technology emerged useful tool documenting existing conditions buildings main application documentation assess current built conditions existing mostly historical buildings technology also used integral part construction progress documentation new projects order equip students knowledge latest technologies industry laser scanning introduced students bim course students given thorough demonstration equipment functions several campus buildings exteriors scanned students chance see scanning action importantly generated point clouds scanner given students part final project five teams formed team given set floor plans minimal details existing campus building teams asked take measurements point clouds model buildings autodesk revit lack marked elevation drawings prevent teams modeling buildings fairly accurately point clouds gave students large amount information lacking provided documents even though learning curve navigating point clouds bit steep extracted information helped students better understand buildings envelopes appreciate real value laser scanning technology
laser therapy therapeutic role various medical conditions recently gained interest non hormonal treatment genitourinary syndrome menopause gsm non invasive option stress urinary incontinence sui several therapies available alleviate gsm symptoms including hormonal non hormonal products microablative fractional laser non ablative vaginal yag laser vel induce morphological changes vaginal tissues data non randomized clinical trials suggest laser therapy alleviate vaginal dryness dyspareunia vel reported improve sui well vaginal prolapse although large randomized trials reported evidence suggests vel offered safe efficacious alternative hormone replacement therapy hrt gsm well first line treatment mild moderate sui surgical procedures resorted randomized studies needed compare laser treatments therapies well assess duration therapeutic effects safety repeated applications research presently evaluating automated robotic probe vel treatments intraurethral probe treatment severe type iii sui elsevier rights reserved
latency pressing problem virtual reality applications low latencies required reduce perceptual artifacts cyber sickness additionally latency jitter denotes variance pattern latency changes additionally may cause unwanted effects paper analyzes latency jitter caused typical inter thread communication itc techniques commonly used todays computer systems employed influence operating system scheduler effect different garbage collection methods understand effect latency spikes different java virtual machines jvm measure scalability latencies various itc techniques increasing number threads actors performing prototypical concurrent tasks four different benchmark implementations vanilla linux kernel well real time linux kernel assess variant multiuser multiprocess operating system prevent latency spikes behavior would apply different programming languages itc techniques confirmed scheduler prioritization application play important role identified impact implementation strategies also linux limit latency jitter cost throughput certain implementations expected choice method also critical change latency patterns drastically result suggest coarse grained concurrency employed avoid adding scheduler latencies unwanted latency jitter native itc case actor systems found support higher degree concurrency granularity higher level abstraction
lateral dynamic soil pile interaction investigated improved tajimi type solution soil treated continuum hysteretic material damping previously proposed authors pile modelled beam using traditional strength materials solutions following pioneering work novak nogami accurate analytical model static harmonic response pile soil layer overlying rock proposed closed form expressions pile head stiffness derived results validated comparisons rigorous solutions literature hereafter winkler model considered simple alternative predicting pile head stiffness damping extensive review available winkler moduli demonstrated winkler model performance strongly depends selection respective moduli found satisfactory static conditions existing expressions dynamic winkler moduli found render model incapable capturing resonant effects consequently new expression dynamic winkler modulus derived based modification classic dynamic plane strain modulus baranov novak implemented winkler model expression capable accurately computing dynamic stiffness attenuation damping increase frequencies first resonance wide range pile slenderness ratios
latest study showed novel translocation programmed cell death ligand cluster differentiation tumor protein found diffuse large cell lymphoma dlbcl resulting conjunct overexpression tumor cells rna level however expressed pattern genes protein level dlbcl remains largely unknown clinical relevance expression dlbcl also unclear tumor tissues chinese dlbcl patients immunostained programmed cell death using envision system clinical relevance dlbcl analyzed chi square test kaplan meier curves log rank test cox proportional hazards regression model mainly expressed tumor infiltrating lymphocytes tils patients expressed tumor cells patients immunostained nucleoli tumor cells cases expression significantly associated patients gender symptoms dlbcl expression tumor cells showed low international prognostic index ipi score tils related prolonged overall survival rate dlbcl patients whereas expression associated worse clinical outcome patients immunoreactivity correlated patients survival time besides expression patients age ann arbor stage ipi score significant prognostic markers prognostic significance frequently expressed dlbcl blockade may potential therapeutic strategy patients
latina youth lag behind asian american non latina white youth many academic areas previous research taken deficit approach understand factors affect academic outcomes latina youth often neglecting highlight potential positive negative contributions gender role values present study took holistic perspective understand affect traditional latina gender role values marianismo machismo caballerismo academic attitudes educational goals mexican descent youth structural equation models tested examine associations positive negative gender role values educational goals using mexican descent adolescents mid sized city southern texas hypothesized positive aspects traditional latina gender role values positive marianismo caballerismo would associated positive attitudes toward academics higher educational goals expected negative gender role values negative marianismo machismo opposite effect additionally based theory planned behavior gender schema theory academic attitudes hypothesized mediate relation gender role values educational goals alternative model tested educational goals mediated relation gender roles academic attitudes results indicated models fit data well recommendations made future longitudinal research aimed disentangling directionality relations model implications research practice discussed
law enforcement represents unpredictable work environment range physical tasks demanding high levels strength muscular power anaerobic power aerobic endurance common injuries among officers include sprains strains back ankle hamstring rotator cuff predominant injury sites relying published research evidence established systematic exercise program design procedures exercise professionals create effective job specific training programs law enforcement officers law enforcement officers represent tactical athletes need deserve advanced exercise prescription safely effectively meet demands jobs throughout careers
dopa remains benchmark treatment parkinson disease motor symptoms chronic use leads dopa induced dyskinesia lid serotonin system established key modulator lid receptors htar stimulation shown convey anti dyskinetic effects however htar agonists often compromise clinical efficacy display intrinsic side effects site actions remain debatable recently highly selective protein biased htar agonists shown potently target hta auto hetero receptors respectively current investigation sought identify signaling mechanisms neuroanatomical substrates htar produce behavioral effects experiment hemi parldnsonian dopa primed rats received systemic injections vehicle min prior dopa lid motor performance syndrome rated compounds significantly reduced lid without affecting motor performance however acute administration significantly induced syndrome anti dysldnetic doses experiment elucidated role striatal htar effects hemi parkinsonian dopa primed rats received bilateral intra striatal microinjections either side side min prior systemic dopa intra striatal effects mimicked systemic effects suggesting striatal htar sub populations play important role anti lid pro syndrome profiles finally experiment examined effects receptor dill agonist induced dyskinesia administering either compound min prior skf resulted mild delay mediated dysldnesia effect collectively data suggest series compounds articulate anti lid effects activation diverse set striatal hta hetero receptor populations elsevier inc rights reserved
leaf area index lai key parameter characterize vegetation dynamics ecosystem structure determines ecosystem functions services clean water supply carbon sequestration watershed however linking lai dynamics environmental controls coupling biosphere atmosphere anthroposphere remains challenging type studies rarely done watershed scale due data availability present study examined spatial temporal variations lai five ecosystem types within watershed complex topography upper heihe river basin major inland river arid semi arid western china integrated remote sensing based glass global land surface satellite lai products interpolated climate data watershed characteristics land management records period determined relationships among lai topography air temperature precipitation grazing history five ecosystem types using several advanced statistical methods show long term mean lai distribution obvious vertical pattern controlled precipitation temperature hilly watershed overall watershed wide mean lai increasing trend overtime ecosystem types presumably result global warming wetting climate however fluctuations observed lai pixel scale varied greatly across watershed classified vegetation changes within watershed improved stabilized degraded according respective lai changes found climate driver temporal vegetation changes land cover types grazing partially contributed decline lai areas masked positive climate warming effects areas extreme weathers cold spells droughts could substantially affect inter annual variability lai dynamics concluded temporal spatial lai dynamics rather complex affected climate variations human disturbances study basin future monitoring studies focus functional interactions among vegetation dynamics climate variations land management human disturbances published elsevier
leaf mass per area lma primary plant functional trait represents cost constructing leaf ultimately plants modify lma altering leaf thickness leaf dry matter content ldmc lma modified constituents studies lma found variation whether ldmc changes responsible lma relationships change depending species functional groups compared study used phylogenetic framework determine evolutionary shifts lma driven ldmc among serengeti grass species considered two alternative hypotheses could result evolutionary correlation lma ldmc either labile ldmc therefore less costly means change lma ldmc tightly coupled different dimension leaf variation leaf hydraulics leaving source variation lma labile ldmc leading conclude evolution lma shaped ldmc responding demands leaf physiology speculate leaf hydraulics provide constraint ldmc decoupling ldmc may allow plants better optimize resource allocation ecosystems gradients light competition herbivory aridity place competing demands leaf economics
learning analysis electrical circuits represented circuit diagrams often challenging novice students open research question electrical circuit analysis instruction whether color coding mathematical symbols variables denote electrical quantities improve circuit analysis learning present study compared two groups high school students undergoing first introductory learning electrical circuit analysis one group learned circuit variables black font group learned colored circuit variables blue font indicating variables related voltage red font indicating related current black font indicating related resistance color group achieved significantly higher post test scores gave higher ratings liking instruction finding helpful lower ratings cognitive load black font group results indicate color coding notations quantities electrical circuit diagrams aids circuit analysis learning novice students
leflunomide recently introduced conventional disease modifying anti rheumatic drugs australia several unique methods initiation unique monitoring recommendations distinctive cessation protocol event serious toxicity aim study evaluate initiation monitoring practices australian rheumatologists using leflunomide survey emailed twice approximately months apart rheumatologist members australian rheumatology association wave analysis used assess evidence non response bias response rate survey difference responses waves fifty percent respondents indicated daily initial dose leflunomide commonly prescribed indicated daily whilst preferred initiate leflunomide daily days followed day recommended first marketed responders used doses daily used alternate daily dosing leflunomide patient taking leflunomide alt ast times uln two blood tests responders indicated would stop leflunomide immediately would follow cessation administering cholestyramine washout choice initial leflunomide dose among responding australian rheumatologists varied considerably although preferred use loading dose despite recommendation clinical guidelines use cholestyramine washout procedure hepatic toxicity universal
left atrium function essential cardiovascular performance evaluable two dimensional speckle tracking echocardiography ste aim determine echocardiographic parameters interrelate exercise capacity ventilatory efficiency subjects structural heart disease asymptomatic volunteers sinus rhythm normal biventricular size function recruited community based population individuals moderate severe valvular disease pulmonary hypertension history cardiac disease excluded performed transthoracic echocardiogram assessed left atrial left ventricular mechanics via ste cardiopulmonary exercise testing treadmill took place immediately thereafter peak oxygen uptake served measure functional capacity ventilation carbon dioxide output vco slope surrogate ventilation perfusion mismatch subjects included age years male gender peak strongly correlated age ratio reservoir conduit phase mechanics particularly conduit strain rate showed correlation volume index mechanics similar pattern associations identified vco slope multivariate analysis conduit beta emerged sole independent correlate peak adjusted age ratio adjusted conduit reservoir components mechanics displayed strong associations peak vco slope conduit phase seems best suited echocardiographic marker functional capacity subjects structural heart disease
legs fly pupa tightly folded configuration femur points forward fly emerges pupa legs stretched backwards fly turn long femora inside tight puparium flies captured emergence various moments progress puparium fixed ethanol postfixed bouin solution specimens ranged grade progressive extrication maturation legs excised configurations photographed legs anchored viii abdominal segment puparium pupal sheath podomers arched buckled yet pharate adults initial moment extrication new buckles appeared femora split femora subpodomers instead turning whole femur fly dragged puparium chain short subpodomers linked together transient hinges hinges emerged unsclerotized areas tubular podomer close sclerotized areas juvenile sclerites extrication legs stretched passively process lasted min initial phase seconds residual distortions left hind legs free juvenile adults mechanics buckling straightening discussed viewpoint strength materials elsevier ltd rights reserved
leishmaniasis parasitic disease caused protozoan leishmania genus human vaccine available drugs pentavalent antimonials pentamidine amphotericin used treat patients however high toxicity pharmaceutics emergence parasite resistance high cost showed urgent need identify new targets employed improvement treatment leishmaniasis recent immunoproteomics approach performed leishmania infantum species antigenic proteins recognized antibodies sera visceral leishmaniasis dogs later showed effective diagnostic markers vaccine candidates disease proteins considered hypothetical identified promastigote amastigote like extracts parasites present study aimed use bioinformatics tools select new drug targets hypothetical proteins cellular localization predicted seven membrane proteins well eight cytoplasmic three nuclear one mitochondrial five proteins remained unclassified functions predicted two transport proteins well five metabolic activity three cell signaling fourteen proteins remained unclassified ten hypothetical proteins well anno tated compared homology regarding human proteins two proteins calpain like clavaminate synthaselike proteins selected using docking analysis possible drug targets sense present study showed employ new strategies select possible drug candidates according localization biological function leishmania parasites aiming treat elsevier inc rights reserved
lesbian gay couples definition establish sex specific divisions domestic tasks least literally previous research shown high levels equality characterize domestic work arrangements sex couples study scrutinizes explanations theoretical background stems family economics theory relative resources gender role life course considerations empirical analysis based upon generations gender survey austria belgium france netherlands norway sweden australia results show sex partners engage tasks equally housework sharing pattern less segregated partners workload equally balanced comparative advantages life course differences gender roles contribute explanation higher levels equality sex compared different sex relationships
less information available site dependent differences fetal intrabrain angiogenesis quantitative evaluation especially limited measured area limited cerebral gray white matters periventricular germinal matrix measured vascular density number vessels per square millimeter percent vascular area percentage areas occupied vessels positive microvessels human fetal brains including fetuses weeks gestation weeks weeks site dependent differences examined among cerebral cortex thalamus internal capsule corpus callosum ganglionic eminence midbrain cerebellar cortex nuclei parameters examined tended high cerebral germinal matrix thalamus midbrain cerebellum significant site dependent differences observed lower vascular densities observed internal capsule corpus callosum parts brain larger percent area observed cerebellar nuclei areas vascular density higher early late stage larger numbers positive islands cells early stage although several exceptions percent area stage dependent almost constant many sites consequently except developing nuclei prenatal development intrabrain vessels weeks may proceed without significant changes density
let linear matrix pencil generated given symmetric matrices size rational entries set real vectors pencil positive semidefinite convex semialgebraic set called spectrahedron described linear matrix inequality design exact algorithm genericity assumptions input matrices computes exact algebraic representation least one point spectrahedron decides empty algorithm assume existence interior point computed point minimizes rank pencil spectrahedron degree algebraic representation point coincides experimentally algebraic degree generic semidefinite program associated pencil provide explicit bounds complexity algorithm proving maximum number arithmetic operations performed essentially quadratic multilinear bezout bound resp fixed bound hence complexity polynomial resp conclude providing results experiments showing practical improvements respect state art computer algebra algorithms
let ohm subset open domain fractal boundary partial derivative ohm define proper convex lower semicontinuous functional space ohm partial derivative ohm ohm partial derivative ohm characterize subdifferential gives rise nonlocal venttsel boundary conditions consider associated nonlinear semigroup generated opposite subdifferential prove corresponding abstract cauchy problem uniquely solvable prove unique strong solution solves quasi linear parabolic venttsel problem nonlocal term boundary partial derivative ohm ohm moreover study properties nonlinear semigroup prove order preserving markovian ultracontractive end turn attention elliptic venttsel problem show existence uniqueness global boundedness weak solutions elsevier ltd rights reserved
levonorgestrel lng synthetic progestin used emergency contraception mechanism preventing delaying ovulation level hypothalamic pituitary unit however little knowledge exists lng effects ovary aim study identify effects lng fsh induced beta estradiol production including lng mediated changes global gene expression rat granulosa cells isolated female wistar rats incubated vitro presence absence human fsh progestins end incubations culture media cells collected mrna quantitation results showed ability lng inhibit hfsh induced production aromatase gene expression microarray analysis revealed lng treatment affects functionality particularly related folliculogenesis steroid metabolism results may offer additional evidence mechanisms action lng elsevier ireland ltd rights reserved
liberals conservatives express prejudice toward ideologically dissimilar others brandt previous work ideological prejudice take advantage evidence showing ideology multidimensional social economic ideologies representing related separable belief systems studies total test competing hypotheses multidimensional account ideological prejudice dimension specific symmetry hypothesis predicts social economic ideologies differentially predict prejudice targets perceived vary social economic political dimensions respectively social primacy hypothesis predicts ideological worldview conflict experienced strongly along social economic dimension social specific asymmetry hypothesis predicts social conservatives prejudiced social liberals specific hypotheses economic dimension using multiple target groups multiple prejudice measures global evaluations behavior multiple social economic ideology measures self placement issue positions found relatively consistent support dimension specific symmetry social primacy hypotheses support social specific asymmetry hypothesis results suggest worldview conflict negative intergroup attitudes behaviors dimension specific social dimension appears inspire political conflict economic dimension
licenced oral pharmacotherapies overactive bladder oab act muscarinic receptors beta adrenoceptors search new drugs treat oab novel mechanisms action active aim discovering effective better tolerated agents literature review frequently used pharmacological methods preclinical assessment new agents aimed treating oab isolated organ technique electrophysiological techniques radioligand binding assay animal models carried novel potential developments based recent knowledge urothelial neural mechanisms also discussed isolated organ technique electrophysiological techniques radioligand binding assay effective methods demonstration novel pharmacological target specific high affinity binding site new drug present bladder modulation regulates functions critical pathophysiology oab afterward new drug shown effective animal models oab although translational value models limited poor pathophysiological relationship human oab exciting novel perspectives focusing particular theory mucosal bladder network recently opened new paths discovery assessment new therapeutics field available experimental models still play central role appraisal oab therapeutics however shortcomings paucity effective drugs indicate need new models better reproduce pathophysiological features oab emerging lines research show promise change perspective future evaluation putative drugs required especially light latest knowledge key role mucosal bladder network brain bladder neural pathways
lie symmetry analysis performed two dimensional generalized sawada kotera equation arises various problems mathematical physics exact solutions obtained using lie point symmetries method simplest equation method
lie telling may part normative developmental process children however little known complex interaction social cognitive factors related developmental behavior current study examined parenting style maternal exposure stressors children cognitive abilities relation children antisocial lie telling behavior experimental setting children years participated modified temptation resistance paradigm elicit spontaneous lies results indicate high authoritative parenting high inhibitory control interact predict lower propensity lie lie better semantic leakage control suggests although children lie telling may normative early development relation children cognitive abilities moderated responsive parenting behaviors discourage lying elsevier inc rights reserved
light determines macrophyte distribution community composition biomass shallow lakes therefore vital determine critical underwater light climate thresholds macrophyte degradation recovery study first proposed novel index defined ratio euphotic depth water depth measure underwater light supply macrophytes underwater light environment lake taihu large shallow eutrophic lake characterized based index using field measurements collected years seasons sites distribution macrophyte presence frequency mpf number investigations identified macrophytes divided total number investigations greater xukou bay east lake taihu investigations followed sites distributed east lake taihu proportion macrophyte coverage increased increase significant relationship observed zeu mpf sites macrophytes region high nutrient concentrations serious water pollution better underwater light conditions required growth macrophytes value regarded critical underwater light threshold growth macrophytes lake taihu region ranging usually covered sparse macrophytes region vital macrophyte recovery environmental management lake taihu distribution obtained using modis satellite derived zeu june october xukou bay guangfu bay southern part lake taihu could regarded potentially crucial regions recovery macrophytes perspective underwater light nutrient levels elsevier ltd rights reserved
light profound impact human body visually light determines aspects surroundings perceive interpret non visually light contributes regulating physiology psychology light thus unusual medium work conscious attention new lighting technology aspect falling within control computer controllable solid state lighting advanced commonplace technology world around many characteristics light emitting diode led lighting must fulfill requirements lighting past ability readily integrate led technology digital control systems presents exciting new opportunities possible artificial light sources example potential integrate small form factor led fabric material control remotely internet aspects set technology apart gone unprecedented flexibility presents opportunity new functionality novel interactive solutions light chapter present three categories interactive lighting many concrete examples interacting light center attention interacting light outside attentional field interacting light periphery attention conclude considering factors make lighting special medium peripheral interaction role peripheral interaction play exposing many new degrees freedom ubiquitous digital lighting presents
lignocellulosic biomass gasification followed fischer tropsch synthesis becoming promising pathway produce synthetic biofuels potential coupled combined cycle strategies order coproduce electricity work thermodynamic performance type bioenergy system evaluated exergy analysis base case process combining biomass gasification synthesis combined cycle defined furthermore two alternative configurations modifying base case process considered autothermal reforming atr fraction tail gas increase fuel yield combustion fraction conditioned biosyngas increase electricity production biomass conversion plants simulated using aspen plus obtain data required assessment indirect gasifier gas combustor identified main sources irreversibility within three process configurations exergy destruction ratios respectively gasification subsystem found contribute overall exergy destruction showing efficiency power generation subsystem also shows high contribution overall exergy destruction due high fuel consumption significant thermodynamic irreversibility cycle depending plant configuration overall exergetic efficiencies attained atr case leads higher yield biofuels expense lower electricity production configuration enhances exergetic efficiency system thus thermodynamic performance contrast alternative configuration increased power generation elsevier ltd rights reserved
like traditional machine learning multi label learning faced curse dimensionality feature selection algorithms proposed multi label learning either convert multi label feature selection problem numerous single label feature selection problems directly select features multi label data set however former omit label dependency produce many new labels leading learning significant difficulties latter taking global label dependency consideration usually select redundant irrelevant features actually labels depend may confuse algorithm degrade classification performance select relevant compact feature subset well explore label dependency granular feature selection method multi label learning proposed maximal correlation minimal redundancy criterion based mutual information maximal correlation minimal redundancy criterion makes sure selected feature subset contains class discriminative information meantime exhibits least intra redundancy granulation help explore label dependency study relation label granularity performance four data sets compare proposed method three multi label feature selection methods experimental results demonstrate proposed method select compact specific feature subsets improve classification performance performs better three methods widely used multi label learning evaluation criteria elsevier ltd rights reserved
lime mud papermaking process lmp toxic industrial waste high moisture content fly ash cement aided dewatering lmp developed best efficiency obtained fly ash cement added simultaneously dewatered lmp calcined different temperatures prepare lime available lime content crystalline phases detected mixtures lmp cement presented highest available lime content calcining degrees mixtures lmp fly ash contained lime cao dicalcium silicate beta casio major phases application performance prepared lime investigated using autoclaved products results showed autoclaved products high strength obtained green building materials elsevier ltd rights reserved
limiting post weaning intake young rabbit known improve resistance digestive disorders whereas degradation housing hygiene assumed negative impact health study aims providing insights mechanism digestive health preservation regarding host growth immune response symbiotic digestive microbiota factorial design weaning day day set libitum intake restricted intake libitum high low hygiene housing per group day day animals group subcutaneously immunized ovalbumin ova assess specific immune response blood sampled days age determine total anti ova immunoglobulin type igg haptoglobin levels cecal bacterial community explored per group pyrosequencing genes coding ribosomal rna whereas cecal volatile fatty acid vfa concentrations measured characterize fermentative activity reduction feed intake reduced growth improved feed conversion ratio whereas degradation hygiene conditions slightly decreased feed intake libitum fed rabbits poor hygiene conditions affect weight gain feed conversion improved day restricted feeding led lower mortality day day whereas degraded hygiene conditions decreased overall morbidity reduced intake low hygiene conditions housing affected microbiota composition especially dominant genera belonging ruminococcaceae family moreover low hygiene associated higher ruminococcaceae lachnospiraceae ratio cecal total vfa increased decreased unit respectively feed restricted rabbits neither specific anti ova igg haptoglobin affected treatments total igg concentrations highest animals raised poor hygiene conditions days restriction decreased days restriction high hygiene conditions conclusion degradation hygiene conditions failed induce systematic specific inflammatory response rabbit reduced morbidity instead results suggest microbiota composition would helpful source biomarkers digestive health
limmersive displays virtual reality systems roughly classified spatially immersive displays similar cave like displays large screen simulators head mounted displays former type usually static spatial configuration configured support small group users latter supports single user propose new class actuated reconfigurable display support small groups individual users particular suggest robotic display change shape display change shape support different usage conditions also move rapidly give larger apparent field view individual user explore potential advantages display move independently user present prototype demonstrates potential use scenarios
liquid quantum dots qds used fluorescent films sensor constructing macroscopic responsive liquid system lysine lys challenging task achieve selective macroscopic response towards lys herein present new strategy integrating host guest chemistry liquid system water soluble pillar arene designed synthesized host introduced onto surface peg modified qds host guest interactions obtain liquid qds interaction lys stronger peg causing released qds surface presence lys resulting macroscopic fluorescence quenching smart material shows promise amino acid sensing separation
little known association chronic illness suicidal ideation among dominicans living united states study used data community survey dominican adults new york city included thoughts self harm better dead past month chronic physical illness burden categorized diagnosed conditions adjusted logistic regressions evaluated association number conditions overall stratified sex age adjusted models yielded strong association chronic illness burden among men odds ratio confidence interval women interaction association interest differ significantly younger older adults screening health care practice particularly among dominican men multiple chronic health conditions may warranted
little known experiences lesbian gay bisexual transgender questioning lgbtq students attending religious colleges universities study used grounded theory analyze narratives lgbtq former current students central theme described lgbtq students fight survival five subthemes institutionalized homo transphobia strict school policies enforcement heterosexuality gender conformity discipline conversion therapy culture fear fear exposure homophobic panic code words seeking cover marginalization isolation struggle suffering suicide reconciling faith lgbtq identity coping resilience surviving critical thinking strategic activism implications practice provided
little known treatment patterns injectable osteoporosis therapies months probability discontinuation among patients using ibandronate followed teriparatide zoledronic acid denosumab months discontinuation higher treatment majority patients discontinue injectable osteoporosis treatment end first year following initiation study designed assess frequency treatment discontinuation time among patients initiate injectable osteoporosis therapies retrospective observational study utilized administrative claims database measure discontinuation injectable osteoporosis therapy reported month intervals years eligible patients aged years newly initiated injectable osteoporosis therapy january june continuously enrolled health plan year prior years date first injectable medication received index date follow time ranged months injectable osteoporosis treatments included analysis denosumab ibandronate teriparatide zoledronic acid discontinuation assessed using kaplan meier survival analysis defined time point percentage patients receive dose scheduled time point day grace period allowed accommodate flexibility scheduling post index administrations sensitivity analyses assessed discontinuation using grace periods days total patients met inclusion criteria study utilizing denosumab ibandronate teriparatide zoledronic acid months discontinuation highest among patients using ibandronate followed teriparatide zoledronic acid denosumab months discontinuation higher treatment ibandronate teriparatide zoledronic acid denosumab majority patients discontinue injectable osteoporosis treatment end first year following initiation
livedoid vasculopathy thrombo occlusive disorder presenting recurrent painful ulcers lower extremities association increased level lipoprotein risk factor cardiovascular disease reported danazol used success management none previous studies looked correlation response treatment level aim study demonstrate efficacy low dose danazol treatment effects present four cases successfully treated low dose danazol assessing clinical characteristics laboratory tests including level average age patients years mean duration disease years treatment regime danazol daily led complete healing ulcers reduction pain ranging reduction level limitation study small sample size patients low dose danazol led clinical improvement along significant reduction level
menthol increases drug partitioning surface skin diffusion drugs skin lipid fluidity stratum corneum alters rigidly arranged lipid structure intercellular lipids however menthol solid room temperature difficult determine effects menthol alone study vaporized menthol order avoid effects solvents vaporized menthol applied stratum corneum lipid models comprising composed ceramides cer eos longest lipid acyl chain ceramides stratum corneum lipids associated barrier function skin cer shorter lipid acyl chain ceramides components stratum corneum intercellular lipids associated water retention intercellular lipid structure stratum corneum cholesterol palmitic acid synchrotron ray diffraction differential scanning calorimetry attenuated total reflection fourier transform infrared spectroscopy analyses revealed lipid models composed hexagonal packing orthorhombic packing structures different lamellar periods taken together results revealed menthol strongly affected lipid model composed cer eos therefore menthol facilitated permeation drugs skin liquid crystallization longer lamellar structure importantly simple lipid models useful investigating microstructure intercellular lipids stratum corneum
local high points widely exist wastewater pressure pipe system reality wastewater pumps cyclically switched force mains may always pressurized usually assumed understanding hydraulics gravity driven pipes important reliable operation wastewater pumping study differentiation based method developed determine temporal spatial dynamics wastewater force main solving equations involving pump curves system curves gravity driven pressurized flows solutions equations determine operation points pumps method applied wastewater pumping system city lakeland florida multiple local high low points force main field investigations theoretical analyses incorporated calibrate pump head characteristic curve pipe friction coefficient enabling accurate simulation force main hydraulics simplicity affordability method would interest water utility engineers american society civil engineers
local scour around seabed oil gas water pipelines critically affect stability accurate estimation scour around pipelines therefore key topic research marine engineers paper presents results numerical study clear water scour depth submarine pipeline range steady flow conditions flow field around pipeline scour equilibrium conditions numerically simulated solving reynolds averaged navier stokes equations standard epsilon turbulence closure flow discharge scour hole various flow conditions investigated results used establish relationship flow discharge maximum scour depth incorporating colebrook white equation bed shear stress obtained iterative method developed predict scour depth around pipeline calculated scour depths using proposed method agreed well laboratory measurements average absolute relative error smaller obtained using previous methods therefore proposed method used predict clear water scour around submarine pipelines improved accuracy
location aware recommender systems use location based ratings produce recommendations recently experienced rapid development draw significant attention research community however current work mainly focused high quality recommendations underestimating privacy issues lead problems privacy problems prominent service providers limited computational storage resources leverage cloud platforms fit tremendous number service requirements users paper propose novel framework namely applet protecting user privacy information including locations recommendation results within cloud environment framework historical ratings stored calculated ciphertext allowing securely compute similarities venues paillier encryption predict recommendation results based paillier commutative comparable encryption also theoretically prove user information private leaked recommendation finally empirical results real world dataset demonstrate framework efficiently recommend pois high degree accuracy privacy preserving manner
logo graphical symbol nonverbal communication essence represents visual symbol company product compared written language greater amount information faster easier spread cross national boundaries achieve barrier free communication logo promotion function bring huge profits enterprise good propaganda enterprise logo fit well brand image brand philosophy brand value brand spirit elements without language makes see things behind design desire people exchange graphics effective means logo convey emotion logo also color achieve artistic conception logo
long noncoding rnas lncrnas emerged recently new class genes regulate cellular processes hotair hox transcript antisense intergenic rna approximately long noncoding rna transcribed hoxc locus upregulated various diseases however role hotair parkinson disease remains unclear mouse model developed intraperitoneal injection mptp expression hotair lrrk detected mice human neuroblastoma cell lines syy pretreated mpp effect hotair expression lrrk examined syy cells overexpressing knockdown hotair mtt flow cytometry assay performed measure cell viability apoptosis syy cells found hotair regulated midbrain tissue mtpt induced mice syy cells exposed mpp presence hotair overexpression syy cells expression lrrk increased compared control hotair knockdown showed protective effect cell viability syy cells pretreated mpp hotair knockdown provided protection mpp induced neuronal apoptosis repressing caspase activity finding hotair promoted induced mptp could add understanding molecular mechanisms findings suggested inhibition hotair levels effective disease modifying strategy
longitudinal dispersion coefficient determined experimental procedures natural streams many theoretical empirical equations based hydraulic geometric characteristics developed field experiments longitudinal dispersion coefficient regression analysis carries restrictive assumptions linearity normality homoscedasticity used derive equations generally speaking results obtained regression analyses accurate assumptions often satisfied completely study method called prediction map developed based geostatistics predict longitudinal dispersion coefficient measured discharge values shear velocities conventional parameters hydraulic variables normalized velocity objective overcoming drawbacks indicated part method new procedure called iterative error training procedure ietp developed minimize prediction error prediction error level reduced implementing ietp compared various regression models taking analyzed errors average relative error percentage root mean square error coefficient efficiency coefficient determination scatter index performance evaluation criteria results study indicate approach perform well predicting longitudinal dispersion coefficient applying ietp presented approach yielded lower average relative error percentage root mean square error scatter indices higher coefficient efficiency coefficient determination values compared regression models one important advantages method valuable interpretations prediction map extracted resulting contour maps result accurate predictions obtained compared regression analysis international association hydro environment engineering research asia pacific division published elsevier rights reserved
longitudinal opioid prescription use unknown among hiv infected patients group based trajectory modeling followed multinomial logistic regression used identify distinct trajectories association baseline characteristics among hiv infected unc cfar hiv clinical cohort participants three trajectories identified never sporadic opioid use referent group episodic use associated female sex depression drug related diagnoses antiretroviral therapy use undetectable hiv rna chronic use associated older age female sex mental health diagnoses overall opioid prescription decreased substantially longer time hiv care among episodic chronic users
long span structures susceptible wind induced vibrations due low oscillation frequency low mechanical damping although many efforts made past model vortex induced vibration circular cylinders limited studies found non circular cross sections representative long span bridge decks model vortex induced vibration analysis long span bridge presented paper aeroelastic equation motion model procedure extract aeroelastic coefficients wind tunnel experiments analysis full scale structures incorporating loss spanwise correlation aeroelastic forces comparison simulated full scale measured responses twin deck bridge fred hartman bridge baytown texas discussed six bluff sections deer isle bridge tsurumi bridge fred hartman bridge generic rectangular shaped circular models considered research program elsevier ltd rights reserved
long span suspension bridges must satisfy time spanning long distances limited responses external loads even high intensity structural control offer reliable contribution limit internal forces displacements structural elements extreme events occur wind buffeting regarded one important dynamic excitation long span flexible bridges owing low frequency content characterize spectrum paper suspension bridge model steel frame deck accounted case study performing numerical simulations evaluating first wide collection control strategies including tuned mass dampers mitigating buffeting dynamic vibrations induced strong wind loading subsequently scope extended reference issue robustness control strategies assessing proposed control solutions respect changes parameters control implementations include optimal tuned mass damper schemes identified reduced two degrees freedom structural model efficacy tested full bridge finite element model passive control strategy compared different ones implementing passive semi active hysteretic dampers link deck piers well hybrid control schemes adopt time tuned mass dampers hysteretic dampers important issue robustness control strategies studied reference proposed control schemes hence proposed control solutions evaluated respect capability perform satisfactorily behavior damage elements occurs besides numerical simulations necessary derive quantitative approach formulation evaluation robustness index control system explored reasons base satisfactorily behavior observe highlighted civil comp ltd elsevier ltd rights reserved
long term consequences anesthetic exposure humans well understood possible alterations brain function occur beyond initial anesthetic administration research children adults reported cognitive behavioral changes surgery general anesthesia may short lived patients others changes may persist changes observed humans corroborated large body evidence animal studies support role alterations neuronal survival neuroapoptosis structure altered dendritic glial morphology later behavioral deficits older age exposure various anesthetic agents fetal early life potential anesthetics induce long term alterations brain function particularly vulnerable populations warrants investigation review critically evaluate available preclinical clinical data developing aging brain known vulnerable populations provide insights potential changes may affect general population patients subtle manner addition review summarizes underlying processes general anesthetics produce changes brain cellular systems level current understanding underlying mechanisms anesthetics agents brain systems finally present neuroimaging techniques currently emerge promising approaches evaluate define changes brain function resulting anesthesia short long term elsevier ltd rights reserved
long term follow studies selective parent training programs scarce particularly case effectiveness trials conducted within regular care settings study evaluated year effects programs comet incredible years cope connect differences rate change among programs investigated using latent growth modeling lgm participants parents sought help local service sector units child psychiatric clinics social services centers major problems managing children externalizing behavior parents children boys moderate levels externalizing behavior aged randomized one programs assessments included parent reported measures child externalizing hyperactivity inattention well parenting practices sense competence parents stress depressive symptoms year follow differences child outcomes among programs programs reduced externalizing behaviors large effect sizes negative parenting practices moderate large effect sizes lgm analyses showed behavioral programs comet incredible years produced rapid reductions externalizing behavior course intervention non behavioral program connect connect however program children continued improve intervention overall results indicate programs equally effective clinical setting despite differences theoretical origin
loss dopaminergic neurons within substantia nigra pathological hallmark parkinson disease leads onset motor symptoms previously vitro studies revealed angiotensin ang induced apoptosis dopaminergic neurons type receptor atr findings needed confirmed via animal experiments using rotenone induced rat model observed overactivation ang atr axis since ang level atr expression markedly increased furthermore provided vivo evidence ang directly elicited apoptosis dopaminergic neurons via activation atr rats importantly showed first time oral administration azilsartan newly developed atr blocker approved food drug administration hypertension treatment rescued apoptosis dopaminergic neurons relieved characteristic parkinsonian symptoms rats results support application atr blockers therapy strengthen notion many therapeutic agents may possess pleiotropic action addition main applications
loudspeakers line arrays common reproduction sound systems used real environments theaters stadiums cinemas conference halls synthesizing directivity characteristics linear source sound field emitted vertical line array pointed particular direction using digital signal processing techniques avoiding mechanical movements approach proposed paper obtain desired directivity behavior takes advantage reproduction virtual source frequency independent directivity characteristics using wave field synthesis theory introducing computational complexity reduction full investigation performance technique carried making comparisons approaches proposed literature thus providing overview results achievable digital steering line arrays elsevier ltd rights reserved
low adherence guidelines weight related behaviours dietary intake physical activity among children underscores need better understand parental factors may influence children obesity risk addition often acting primary caregiver children women also known experience greater levels stress men study systematically reviewed associations maternal stress children weight related behaviours search returned eligible articles representing unique associations maternal stress distinct child weight related behaviour healthy diet unhealthy diet physical activity sedentary behaviour overall findings relationship maternal stress children weight related behaviours mixed evidence association children healthy unhealthy dietary intake fairly consistent evidence association maternal stress children lower physical activity higher sedentary behaviour recommendations future research include prioritizing prospective designs identifying moderators use high resolution real time data collection techniques elucidate potential mechanisms
low bioavailability poor absorption turmeric bioactives human body limit application order propose products improved stability investigate quality coprecipitated microparticles polyethyleneglycol peg turmeric extracts obtained using dichloromethane dcm dimethylsulfoxide dmso solvents compressed carbon dioxide antisolvent effects pressure antisolvent flow concentration extract solvent proportion investigated mean size microparticles varied particle size distribution indicate irregularities confirmed polydispersive index pdi values images obtained scanning electron microscopy profile bioactives analyzed using two approaches qualitative thin layer chromatography indicated weak presence quantitative antioxidant activity indicated relevant contribution substances present coprecipitates inhibition beta carotene oxidation besides evidence efficiency peg wall material elsevier rights reserved
low bone mineral density bmd common people living hiv infection plwh increasing fracture risk alcohol use also common plwh modifiable risk factor hiv disease progression low bmd plwh alcohol effect bmd well understood studied adult plwh substance dependence measured lifetime alcohol use recent past day alcohol use categorized abstinent low risk high risk adjusted multivariable regression analyses tested associations lifetime recent alcohol use mean bmd femoral neck total hip lumbar spine low bmd diagnosis osteopenia osteoporosis also examined associations measures past alcohol use total consumption drinking intensity year bmd outcome measures periods hiv care continuum period first positive hiv test period first positive hiv test antiretroviral therapy art initiation iii period following art initiation found significant associations lifetime alcohol use mean femoral neck beta total hip beta lumbar spine beta bmd low bmd diagnosis adjusted odds ratio aor confidence interval significant correlation past day alcohol use mean bmd past day alcohol use associated low bmd diagnosis compared abstainers aor high risk alcohol use aor low risk alcohol use drinking intensity year first positive hiv test art initiation associated lower mean bmd femoral neck beta total hip beta increased odds low bmd aor sample plwh detected association lifetime alcohol use bmd however recent drinking associated low bmd diagnosis drinking intensity first positive hiv test art initiation longitudinal studies confirm associations
low carbon policies including aimed increasing water efficiency adopted crucial strategy combating global warming climate change green building evaluation system used taiwan first applied initially utilized building water efficiency threshold index determining building environmental impact since thousand buildings certified green buildings using evaluation system quantitative effects water conservation efforts provided policy makers form positive feedback end present study offers calculation process estimating quantitative volume water saved practical green buildings baseline water usage kinds buildings determined serve criterion determining water saving efficiency individual buildings investigation average water saving rate buildings certified green buildings also conducted validate estimation results found green buildings saved average approximately compared baseline water usage rate buildings water savings inevitably follow use water saving appliances water saving designs buildings proposed calculation process used clarify relationships specific water saving concepts real water usage efficiency green buildings
low carbon steel weld structures generally exhibit linear stress strain relationship study strength materials compressive strength capacity material structure withstand loads tending reduce size structure mainly measured plotting applied force deformation testing machine compressive strength main key value design welded structures main goal paper analysing plastic properties frame welds made various parameters micro jet cooling new technology micro jet welding could regarded new way improve plastic properties welds allows obtain welds better mechanical properties comparison ordinary welding method furthermore possible steering weld structure properties weld given main information influence various micro jet gases metallographic properties structure steel welds
low concentration particle transport multiphase horizontal pipes presence viscous liquid experimentally investigated experiments conducted wide range liquid gas flow rates intermittent stratified flows critical flow rates velocity defined minimum required liquid gas flow rates velocities keep particles constantly moving pipe effects physical parameters sand concentration sand size pipe size liquid viscosity also experimentally investigated observed critical velocity function sand concentration sand size increases increasing either within ranges particle concentrations sizes examined regarding effect carrier liquid viscosity experimental data reveal increasing viscosity minimum required flow rates constantly move sand along pipe increases within range examined american institute chemical engineers
low empathy prominent trait associated juvenile offenders many juvenile justice service providers strive reduce risk factors associated juvenile delinquency producing evidence based outcomes targeted programming youth services agency ysa nature center provides empathy development animal therapy adjudicated youth project generates evidence based outcomes quantifies impact animal therapy empathy development adjudicated youth ysa nature center utilizing self assessment tools results indicated trends animal therapy increases emotional empathy ysa clients qualitative evidence implied animal therapy notable therapeutic value ysa clients
low feelings meaning life associated depression hopelessness suicide substance abuse emotional dysregulation aim study offer results importance construct meaning life psychopathology bpd study sample made participants participants bpd participants another mental disorder without bpd study sample made participants bpd study indicated participants bpd lower feeling meaning life participants mental disorders without bpd study indicated meaning life highly negatively correlated symptoms bpd model composed emotional dysregulation meaning life significantly associated bpd psychopathology present study supports association meaning life psychopathology bpd copyright john wiley sons ltd
low impact development lid water sensitive urban design one tenets use rainwater harvesting rwh systems provide water use site historically implemented arid semi arid regions rwh recently surged popularity humid regions southeastern usa due increased interest water conservation severe drought conditions lid commercial site raleigh incorporated rwh stormwater control measures mitigate runoff quantity improve runoff quality liter rwh tank used landscape irrigation monitored determine influent effluent water quality samples analyzed total nitrogen total phosphorus total kjeldahl nitrogen tkn total ammoniacal nitrogen tan nitrite nitrate nox orthophosphate ortho total suspended solids tss low concentrations observed pollutants monitored example influent effluent concentrations respectively statistical testing showed significant increases tan organic nitrogen concentrations respectively inflow outflow nox tss concentrations decreased significantly respectively concentrations pollutants significantly different inflow outflow influent concentrations rwh tank less previously published rainfall pollutant concentrations indicating potentially irreducible concentrations onsite single case study rwh system appears offer pollutant mitigation especially tss
low solar energy harvesting conversion efficiency become major problem solar energy science engineering owing difficulty capturing solar energy across wide solar spectrum especially visible light range inspired extraordinary properties materials arising decreased dimensions study explore nanocontact system formed two dimensional tio monolayer semiconductor cdx nanocages engineering visible light absorption nanocontact system via either bond coupling mechanism forms ideal type band alignment stronger donor acceptor coupling contact system efficiently relaxes coupled geometry helps couple electrons therefore leading enhancement absorption peaks visible frequency range changing element cdx red shift visible light absorption peaks accompanied stimulating optical response whole nanocontact system observed nanocontacting semiconductors comprising low dimensional cdx nanocage tio monolayer systems promote charge separation optical absorption visible range arise effects adsorbent nature decreasing size efficient interfacial coupling mechanism therefore promising photovoltaic photocatalytic materials
low total testosterone sexual symptoms common among men coronary artery disease however impact major adverse cardiovascular events mace still debatable investigated whether low coexisting sexual symptoms men acute coronary syndrome acs used predict incidence mace prospective study consecutive men mean age years diabetes current smokers left ventricular ejection fraction acs included group men presence three sexual symptoms decreased frequency morning erections lack sexual thoughts erectile dysfunction serum concentration distinguished patients prognosis assessed according global registry acute coronary events grace score primary composite endpoint mace recurrent ischaemia non fatal myocardial infarction stroke death secondary endpoint stent restenosis isr registered month follow period mean level entire group low diagnosed men low sexual symptoms diagnosed participants follow participants experienced mace men isr cox proportional hazards regression high risk death grace score presence low sexual symptoms independently predicted incidence mace secondary endpoint low sexual symptoms independent covariates predicted irs low coexists sexual symptoms males acs used predict mace especially irs independently classic cardiovascular risk factors
low income housing lih projects vital role developing countries serve large sector society hence considered one important projects funded governments total life cycle cost lcc projects incurred use phase making projects lose economic aspect sustainability therefore important decrease costs projects life cycle taking consideration available resources paper focuses two aspects sustainability building life cycle environmental economic purpose methodology considers reasonable costs fit lih projects using environmentally friendly materials methodology based assessing lcc lih projects taking consideration initial cost operation costs paper focuses green building materials minimal cost corresponding maximum number points awarded leadership energy environmental design leed rating system methodology developed formulation system dynamics model using stella software package proposed model capable considering dynamic nature interactions among major variables affecting assessment economic environmental performances selected green materials proposed assessment methodology helps decision makers governmental housing authorities modify current management policies improving current situation lih addition aids government contractors minimize lcc achieving maximum leed material credit points lih projects detailed case study egypt presented clarify practical features proposed model elsevier rights reserved
lufft chm nimbus ceilometer collocated cimel sunphotometer used tandem satellite data observe transport atmospheric aerosols raciborz poland exceptionally warm month august two distinct periods identified increased aerosol optical thickness aot values exceeding august concurrent planetary boundary layer elevated similar thin aerosol layers ground visible august newly developed scheme backward air mass trajectory analysis employed scheme utilizes satellite data thermal anomalies well multiangle imaging aerosol clouds obtained retrievals provide evidence aerosols biomass burning type present first period originating strong episode wildfires ukraine moreover satellite aot data modis instrument show significant part observed aerosol accumulated transport region intense biomass burning receptor raciborz analysis scheme suggests long range transport biomass burning products united states source layers observed second period authors published spie
lumbosacral spina bifida common debilitating birth defect whose multiple causes poorly understood provide first genetic delineation cholinergic nicotinic receptor alpha chrna expression link ablation chrna cell lineage condition mouse using homologous recombination ires cre cistronic cassette introduced noncoding region chrna chrna cre identifying cell lineages expressing gene lineage first appears embryonic day rhombomeres neural tube extends cell subsets tissues ablation chrna cre cell lineage embryos crosses conditionally expressed attenuated diphtheria toxin results precise developmental defects including omphalocele open spina bifida hypothesized like humans defect would modified environmental compounds folic acid choline also nicotine prenatal chronic oral nicotine administration substantially worsened defect often include rostral neural tube contrast supplementation maternal diet choline decreased prevalence dramatically reduced defect severity folic acid supplementation trended towards reduced frequency omphalocele unaffected interventions studies identify chrna cell lineage participating posterior neuropore closure present novel model lower substantially modified prenatal environment wiley periodicals inc
lump solutions rationally localized directions space general class lump solutions dimensional kadomtsev petviashvili bkp equation presented symbolic computation maple hirota bilinear form equation starting point computation process like equation resulting lump solutions contain six arbitrary parameters two parameters due translation invariances bkp equation independent variables four need satisfy nonzero determinant condition positivity condition guarantee analyticity rational localization solutions
lung fibrosis results cumulative effect dysfunctional wound repair involving multiple cell types including fibroblasts epithelial cells macrophages responding array soluble matrix mediated stimuli recent studies shown tyrosine kinase inhibitor targets fgf vegf pdgf receptors slow rate decline pulmonary function patients idiopathic pulmonary fibrosis however growth factor families comprised multiple ligands receptors pleiotropic activities different cell types broad inhibition might pro fibrotic anti fibrotic effects limiting potential therapeutic efficacy continued investigation delineation specific roles individual proteins receptors different cell types hold promise targeting specific pathways precision optimizing potential efficacy future approaches lung fibrosis therapy copyright pathological society great britain ireland published john wiley sons ltd linked article
lung transplantation effective safe therapy carefully selected patients suffering variety end stage pulmonary diseases lung cancer negatively affects prognosis particularly patients longer candidates complete resection lung transplantation considered carefully selected well staged lung cancer patients proven lung limited multifocal minimally invasive adenocarcinoma situ ais previously called bronchioloalveolar cell carcinoma causing respiratory failure despite substantial risk tumour recurrence lung transplantation may offer survival benefit years best palliation disease reports lung transplantation low grade malignancies rare lung transplant candidates higher risk developing lung cancer mainly previous smokers chronic obstructive lung disease copd idiopathic pulmonary fibrosis ipf older patients thoroughly repeatedly screened lung cancer prior listing preferably also waiting list time longer year including use pet scan ebus assisted bronchoscopy case undefined suspicious pulmonary abnormalities double lung transplantation replace single lung transplantation high risk patients prevalence lung cancer developing remaining native lung patients unexpected early stage bronchial carcinoma explanted lung may favourable survival without recurrence early pet months following lung transplantation advisable detect early subclinical disease progression donor lungs former smokers well examined retrieval suspicious nodules biopsied avoid grafting cancer recipient close follow regular visits screening test recipients needed increased risk developing primary secondary cancer allograft either donor recipient origin
machine design one important tasks present scenario presently machine design done taking account variables operating conditions process time consuming error prone inefficient design methodology due lack optimization performance individual components performance machine whole deteriorates paper aims demonstrating versatility contract based design methodology design machines overcome drawbacks traditional designing process process variables involved complex process best modeled fuzzy variables take non discrete values fuzzy variables analyzed using contract based design illustration lathe machine used enhance machining capability suppressing vibrations using fuzzy controller contract based design leads accurate machining better tolerances surface finish
machine learning algorithms perform differently settings varying levels training set mislabeling noise therefore choice right algorithm particular learning problem crucial contribution paper towards two dual problems first comparing algorithm behavior second choosing learning algorithms noisy settings present sigmoid rule framework used choose appropriate learning algorithm depending properties noise classification problem framework uses existing model expected performance learning algorithms sigmoid function signal noise ratio training instances study characteristics sigmoid function using five representative non sequential classifiers namely bayes knn svm decision tree classifier rule based classifier three widely used sequential classifiers based hidden markov models conditional random fields recursive neural networks based sigmoid parameters define set intuitive criteria useful comparing behavior learning algorithms presence noise furthermore show connection parameters characteristics underlying dataset showing estimate expected performance dataset regardless underlying algorithm framework applicable concept drift scenarios including modeling user behavior time mining noisy time series evolving nature
machine learning based computational intelligence methods widely used analyze large scale data sets age big data extracting useful predictive modeling types data sets challenging problem due high complexity analyzing large amount streaming data leveraged derive business value another complex problem solve high levels data availability big data automatic classification become important complex task hence explore power applying mapreduce based distributed adaboosting extreme learning machine elm build predictive bag classification models accordingly data set ensembles created elm algorithm used build weak learners classifier functions builds strong learner set weak learners applied training model benchmark knowledge discovery data mining data sets
magnetically modified clays low cost materials promising properties using sorption pollutants wastewaters influence extraction agents released iron oxides nanoparticles nps magnetically modified kaolinite studied article stability mentioned new smart material evaluated leaching test characterization prepared sample investigated using ray fluorescence spectroscopy ray powder diffraction spectroscopy spectroscopy sem leachates prepared according european technical standard material interacted demineralization water extraction agents treated solution hso naoh solution discontinuous rotation container laboratory temperature hours stability magnetically modified kaolinite evaluated basis released accompanying elements kaolinite structure elements determined decomposition filtrate hno atomic emission spectrometer inductively coupled plasma
main conclusion overexpression citrus cstip improves plant growth tolerance salt drought stresses enhancing cell expansion detoxification stomatal conductance tonoplast intrinsic proteins tips subfamily aquaporins belonging major intrinsic protein family previous study shown citrus tip isoform cstip highly expressed leaves also transcriptionally regulated leaves roots salt drought stresses infection candidatus liberibacter asiaticus causal agent huanglongbing disease suggesting involvement regulation flow water nutrients required normal growth stress conditions show overexpression cstip transgenic tobacco increases plant growth optimal water salt stress conditions also significantly improves leaf water oxidative status photosynthetic capacity transpiration rate water use efficiency plants subjected progressive soil drying results correlated enhanced mesophyll cell expansion midrib aquiferous parenchyma abundance detoxification stomatal conductance observed transgenic plants taken together results indicate cstip plays active role regulating water oxidative status required plant growth adaptation stressful environmental conditions may potentially useful engineering stress tolerance citrus crop plants
maintaining multivariate calibrations involves keeping models developed instrument applicable predicting new samples time sometimes primary instrument model needed predict samples measured secondary instruments situation referred calibration transfer sometimes primary instrument model needed predict samples acquired new spectral features chemical physical environmental influences time situation referred calibration maintenance calibration transfer maintenance problems long history well studied chemometrics spectroscopy disciplines outside chemometrics particularly computer vision calibration transfer maintenance problems recent phenomena problems often umbrella term domain adaptation past decade domain adaptation demonstrated significant successes various applications visual object recognition since domain adaptation already constitutes large area research computer vision machine learning narrow scope report penalty based eigendecompositions class domain adaptation methods motivational roots linear discriminant analysis compare approaches chemometrics based approaches using several benchmark chemometrics data sets disciplines outside chemometrics particularly computer vision problems involving calibration updating calibration transfer maintenance recent phenomena problems often umbrella term domain adaptation report penalty based eigendecompositions class methods motivational roots linear discriminant analysis methods coopted chemometrics based purposes compared known calibration updating methods
maintenance ballasted railway tracks major cost railway infrastructure owners many developed countries much railway infrastructure mature built service requirements long since superseded increased demands historic infrastructure lead development exacerbation localised trackbed problems require disproportionate levels maintenance identifying applying cost effective remediation potential reduce maintenance spend long term however always clear cost effective remediation one type localised maintenance issue development wet beds wet spots occur saturated clayey subgrade soils overloaded result development mud pumping trains pass leads migration fines ballast bed deterioration local track performance time track overlying wet bed settles disproportionately sleepers become progressively voided train ride quality deteriorates maintenance wet bed may involve locally digging replacing ballast however unless underlying cause addressed problem likely recur requiring repeated localised maintenance interventions costly reactive ultimately ineffective approach managing problem paper presents study wet bed prior full track renewal transient track deflections train passage monitored using sleeper mounted geophones high speed filming techniques loaded track geometry data obtained track recording vehicle shown local maintenance interventions generally ineffective renewal top trackbed including placement geotextile filter geogrid appears successful remediating problem least short term
major advances made past years development integrated computational materials design icmd technology hierarchical structure methods tools supporting fundamental materials databases reviewed emphasis successful applications calphad calculation phase diagrams based tools example icmd expressing mechanistic understanding quantitative form support science based materials engineering opportunities identified rapid expansion calphad databases well major restructuring materials education
major depressive disorder mdd presents variety symptoms responds wide range treatment interventions diagnostic criteria collapse multiple syndromes distinct etiologies disorder mdd typically understood malfunction neurotransmission brain circuitry regulating mood pleasure reward executive function however research evolutionary perspective suggests normal functioning adaptations may also generate symptoms meeting diagnostic criteria functioning adaptations may underappreciated etiological pathway mdd many adaptive functions depressive symptoms suggested biasing cognition avoid losses conserving energy disengaging unobtainable goals signaling submission soliciting resources promoting analytical thinking review potential role adaptive functions lead specific clusters depressive symptoms understanding mod perspective reduces heterogeneity cases may help select best intervention patient discuss implications different adaptive maladaptive etiological pathways use antidepressants various modes psychotherapy particular instances mdd caused functioning adaptations may benefit treatments support adaptive function target precipitating causal stressor conclude evolutionary approach study mdd may one promising approaches reduce heterogeneity better match patients treatment elsevier rights reserved
majority chemical processes process industry modeled first order plus dead time processes present analysis selected process model transfer function taken consideration pid controllers designed process using various tuning techniques effect dead time compensated using smith predictor
making decisions using judgements multiple non deterministic indicators important task everyday professional life learning decision making often studied mapping stimuli cues environmental variable criterion however little attention paid effects situation person interactions learning accordingly manipulated cue feedback presentation mode graphic numeric task difficulty measured individual differences working memory capacity wmc predicted graphic presentation fewer cues elevated wmc would facilitate learning person task characteristics would interact presentation mode compatible decision maker cognitive capability enhanced visual verbal wmc would assist learning particularly difficult tasks found predicted main effects significant interactions except greater wmc benefited larger extent graphic numeric presentation regardless type working memory enhanced number cues findings suggest conclusions past research based predominantly tasks using numeric presentation need reevaluated cast light working memory helps learn multiple cue criterion relationships implications dual process theories cognition
making oral contraceptives ocs available counter otc could help reduce high rate unintended pregnancy united states surveys show widespread support otc access ocs among women studies indicate women accurately use checklists identify contraindications ocs continuation good better among otc users compared women using ocs obtained prescription women clinicians expressed concerns related making ocs available otc concerns addressed existing data research required food drug administration part application make ocs available otc
malaria human serious fatal tropical disease disease results anopheles mosquitoes infected plasmodium species clinical diagnosis malaria based history symptoms clinical findings must always confirmed laboratory diagnosis laboratory diagnosis malaria involves identification malaria parasite antigen products blood patient manual diagnosis malaria parasite pathologists proven become cumbersome therefore need automatic efficient accurate identification malaria parasite paper proposed computer vision based approach identify malaria parasite light microscopy images research deals challenges involved automatic detection malaria parasite tissues proposed method based pixel based approach used means clustering unsupervised approach segmentation identify malaria parasite tissues
malaria life threatening parasitic infection occurring endemic areas primarily children age five pregnant women patients human immunodeficiency virus acquired immunodeficiency syndrome hiv aids well non immune individuals cytoadherence infected erythrocytes ies host endothelial surface receptor known factor contributes increased prevalence severe malaria cases due accumulation ies mainly brain vital organs therefore study needed discover new potential anti adhesive drug treat severe malaria thus reducing mortality rate review discuss aptamer technology could applied development new adjunct therapy current malaria treatment
malaysia holds variety energy resources oil natural gas coal renewable energies biomass solar hydro spite abundant resources nation still reliant fossil fuel industrial transportation sector even though fossil fuel depleting worldwide regard renewable energy resources becoming attractive sustainable energy development malaysia bioethanol one potential biofuel high octane number replaced lead octane enhancer petrol bioethanol fermentation process possesses complex dynamics caused microorganisms involved process well variation biomass composition operating conditions work nonlinear model known nonlinear autoregressive exogenous input model developed embedded model predictive control strategy control fermentation process performance nonlinear autoregressive exogenous input model predictive control evaluated compared linear model predictive control proportional integral derivative controller set point tracking disturbance rejections robustness tests also carried using linear nonlinear model predictive controls proposed robustness test nonlinear model predictive controller successfully settled back original product concentration fermenter temperature set points settling time three hours meanwhile linear model predictive controller settled product concentration set point fermenter temperature set point settling time five hours results nonlinear autoregressive exogenous input model predictive control shown better performance robust compared linear model predictive control proportional integral derivative controller elsevier ltd rights reserved
male low birthweight vlbw infants prone females health developmental problems less positive mother infant interactions gender differences brain development social relationships suggest hormonal influences quality mother infant interaction authors explored associations maternal infant salivary testosterone cortisol levels mother infant interactions sample whole gender controlling covariates data collected prospectively mothers vlbw infants infant record review maternal interview biochemical measurement mothers infants observation mother infant interactions weeks postmenstrual age three six months corrected age infants positive interactions increased mothers decreased three six months generalized estimating equation gee analyses controlling covariates higher maternal testosterone infant cortisol associated positive frequent maternal interactive behaviors gee analyses infant gender controlling covariates effects maternal infant hormone levels became significant especially infants interactive behaviors based preliminary findings among vlbw infants males high testosterone expected less positive mother infant interactions males low testosterone female infants wiley periodicals inc
management daily stress greatly improved delivering sensor triggered time interventions jitis mobile devices success jitis critically depends able mine time series noisy sensor data find opportune moments paper propose time series pattern mining method detect significant stress episodes time series discontinuous rapidly varying stress data apply model weeks physiological gps activity data collected users natural environment discover patterns stress real life find duration prior stress episode predicts duration next stress episode stress mornings evenings lower day analyze relationship stress objectively rated disorder surrounding neighborhood develop model predict stressful episodes
management gut related symptoms pediatric population challenging many factors need taken consideration including psychological behavioral social family environments growth developmental requirements review focuses two issues potential dietary therapies thought relieve symptoms infantile colic condition believed gastrointestinal nature evidence dietary considerations surrounding children irritable bowel syndrome
manet mobile hoc network wireless network group nodes communicating without infrastructure security manet desirable researching point one well known threats manet black hole threat many approaches featured bypass kind threats however solutions prevent avoid threat totally different degrees affect performance manet negatively paper implement new approach named local intrusion detection bluff probe packet lidbpp proposed order solve black hole problem bluff packet contains virtual destination address created trick black hole new approach adopts novel strategy detection multiple black hole attacks minimum negative effect performance network algorithm simulated using simulator examine ability proposed lidbpp approach block black hole attack simulation also used measure much approach may influence network performance simulation results show lidbpp prevents collaborative black hole attacks less negative impact performance manet close performance manet without assumed black holes simulation also done compare performance manet case lidbpp case maodv detection using negotiation neighbors simulation proves performance network slightly better existence lidbpp
mannose binding lectin mbl associated serine proteases masps enzymatic constituents lectin pathway complement system complexed large pattern recognition molecules prms mbl collectins ficolins main function two three masps crystallized lately masp autoactivates first activates masp finally participate formation cba convertase addition enzymes involved several processes subject intense research nowadays notably masp promiscuous enzyme implicated coagulation cascade kinin generating contact system cellular activation protease activated receptor par cleavage endothelial cells third protease masp emerged recently protease responsible pro factor activation resting blood providing fundamental link two complement pathways present three masps least one well defined role several possible functions implicated defect likely activation masps may culminate diseases ischemia reperfusion injury iri hence masps potential targets drug development
many applications require specialized data structures found standard libraries implementing new data structures hand tedious error prone paper presents novel approach synthesizing efficient implementations complex collection data structures high level specifications describe desired retrieval operations approach handles wider range data structures previous work including structures maintain order among elements complex retrieval methods prototyped approach data structure synthesizer called cozy four large real world case studies compare structures generated cozy handwritten implementations terms correctness performance structures synthesized cozy match performance handwritten data structures avoiding human error
many breast cancer deaths result tumors acquiring resistance available therapies thus new therapeutic agents needed targeting drug resistant breast cancers drug refractory breast cancers include tumors acquired resistance targeted antibodies kinase inhibitors triple negative breast cancers tnbcs lack therapeutic targets estrogen receptor progesterone receptor significant fraction tnbcs overexpress family member epidermal growth factor receptor egfr thus agents selectively kill egfr tumors would provide new options breast cancer therapy previously identified class compounds termed disulfide bond disrupting agents ddas selectively kill egfr breast cancer cells vitro blocked growth breast tumors animal model dda dependent cytotoxicity found correlate downregulation akt dephosphorylation demonstrate ddas activate unfolded protein response upr plays role ability kill egfr cancer cells use breast cancer cell lines ectopically expressing egfr pharmacological probes upr revealed three dda responses downregulation akt dephosphorylation upr activation contribute dda mediated cytotoxicity significantly egfr overexpression potentiates responses combination studies ddas suggest may complementary egfr specific receptor tyrosine kinase inhibitors mtorc inhibitors overcome drug resistance
many children autism spectrum disorders asd developmental disabilities unable meet daily communication needs speech alone individuals considered potential candidates speech generating devices sgds mobile technologies aac specific applications purpose study determine effectiveness systematic instruction teaching multistep requesting skills using ipad loaded proloquogo children asd developmental disabilities participants study four children ages years diagnosed asd developmental disabilities results indicated participants intervention effective increasing multistep requesting using ipad participants successful varying degrees navigating across pages combining symbols request preferred items additionally participants demonstrated generalization newly acquired skills requesting different preferred items activities generalization probes results discussed implications research practice presented
many cities around world reached critical situation comes energy water supply threatening urban sustainable development engineering architecture perspective mandatory design cities taking account energy water issues achieve high living sustainability standards aim paper develop optimization model planning residential urban districts special consideration renewables water harvesting integration optimization model multi objective uses genetic algorithm minimize system life cycle costs maximize renewables water harvesting reliability dynamic simulations developed model used spatial optimization design new urban districts also employed analyzing performances existing urban districts energy water economic viewpoint optimization results show reliability hybrid renewables based power system vary depending scenarios considered regarding built environment area cases concerning overall electric load levelized cost electricity vary maximum water harvesting system reliability vary depending built environment area distribution reliabilities levelized cost water kept making competitive network water tariff elsevier ltd rights reserved
many clinical molecular features fragile syndrome common form intellectual disability autism modeled deletion fmr protein fmrp mice previous studies showed decreased expression several components gabaergic system fmr knockout mice used mouse model investigate functional consequences fmrp deletion hippocampal gabaergic inhibition region hippocampus whole cell patch clamp recordings demonstrated significantly reduced amplitude evoked inhibitory postsynaptic currents eipscs decrease amplitude frequency spontaneous ipscs addition miniature ipscs reduced amplitude frequency decayed significantly slower mipscs controls quantitative real time pcr revealed significantly lower expression alpha beta delta gaba receptor subunits hippocampus juvenile mice compared wild type littermates correspondingly found also protein level reduced amounts alpha beta delta subunits fmr knockout mice overall results demonstrate reduction several components gabaergic system already present young age reduction results measurable abnormalities gabaa receptor mediated phasic inhibition abnormalities might contribute behavioral cognitive deficits fragile mouse model elsevier ltd rights reserved
many computer applications require solving difficult problems pspace expensive analyze space feasible solutions last years theoretical computer science area showed enormous progress algorithm design put practice experimental algorithmic help bridge gap theory practice domain applications involves hard problems development computer games particular games user opponent computer heuristic search technique games highly successful however tools assist testing improving implementations based paper describe framework called gliese focuses reuse software components experimental game development main goal provide software support simplify complex issues implementation video games enabling experiment games parts logic expressed using different heuristic searches simulation assess quality approximate solution based different heuristic search techniques original aspect impacts game implementation gliese used undergraduate courses analysis design algorithms development variety popular games
many crops ill protected insect pests storage protect cereal grains herbivores storage pesticides often applied pesticides undoubtable functionality increasing concerns arising application present study investigated bioinspired cyanogenic grain coating amygdalin cyanogenic precursor mimicking feeding triggered release hydrogen cyanide hcn found example bitter almonds multilayer coating consisted biodegradable polylactic acid individual layers containing amygdalin beta glucosidase capable degrading amygdalin hcn reaction occurred layers ruptured herbivore attack upon feeding coated cyanogenic wheat grains tenebrio molitor mealworm beetle rhizopertha dominica lesser grain borer plodia interpunctella indianmeal moth reproduction well consumption rate significantly reduced whereas germination ability increased compared noncoated grains field experiments observed initial growth delay compared uncoated grains became negligible later growth stages shown strategy artificially apply naturally occurring defense mechanisms could expanded crops wheat potential replace certain pesticides benefit complete biodegradability increased safety storage
many engineering machines mechanical components subjected fluctuating stresses taking place relatively high frequencies conditions failure found occur fatigue failure led invention fatigue testing machine view effective design fail accidentally research conceived testing machine determine strength materials action fatigue load specimens subjected repeated varying forces fluctuating loading specific magnitude cycles stress reversals counted destruction first test made stretch somewhat ultimate strength material second test made stress less used first process continued results plotted
many fields computing deep packet inspection dpi employ string matching modules smm search given set positive strings input smm expected produce correct outcomes scanning input data high rates furthermore string sets searched usually large sizes increase steadily bloom filters bfs hashing data structures fast false positive results require processing speed exploited standard bloom filter smms sbfs long positive probability low multiple bfs parallel increase throughput paper propose double bloom filter smm dbf achieves higher throughput sbf maintains high throughput even large positive probabilities second bloom filter dbf stores small enough subset positive strings false positive probability approximately zero develop analytical model dbf show throughput advantage dbf sbf becomes prominent positive probability fraction matches second bloom filter increase accordingly propose heuristic algorithm stores strings frequently matched second bloom filter according localities identified input numerical results obtained using realistic values fpga implementation validated systemc simulations
many forensic psychiatric settings serve unique populations addition traditional psychiatric symptoms diverse legal criminogenic needs lack clear treatment standards address aspects forensic care lead inefficient inappropriate interventions contribute institutional violence
many industrial processes inevitably produce excess heat product recovering heat matter waste management provides opportunities improve energy use efficiency excess heat used heating purposes processes delivered district heating systems buildings generate electricity increasingly applied technology industrial excess heat recovery organic rankine cycle orc suitable recover low grade heat degrees onwards although orcs studied intensively studies examined economics commissioned orc systems paper investigates kwgross orc system employed flue gas heat recovery industrial kiln flanders belgium purpose study twofold providing insight practical orc case evaluating financial feasibility taking specific policy circumstances account financial appraisal takes account specific technical setup diverse costs system external economic parameters policy circumstances europe belgium flanders sensitivity analysis illustrates influence parameter results analysis demonstrates dominance investment costs sic gross expenses valid conditions investment positive financial return financial support government indispensable finally sensitivity analysis reveals importance attaining sufficient load hours influence electricity prices financial feasibility orc projects results suggest orc systems suitable industrial excess heat electricity production certain conditions financial support remains necessary reducing investment costs orc could alleviate conditions elsevier ltd rights reserved
many institutions globally advanced use elearning brings positive benefits towards development quality education success elearning institution depends well information communication technologies icts utilised good quality standard design content elearning websites meet needs students particular however benefits challenges elearning discussed variety studies globally moreover understanding student attitudes perceptions towards elearning critical issue improving value use elearning systems tertiary education strength materials information technology management two bachelor technology btech courses research conducted part time students unable attend courses day due various reasons therefore researcher interest identity assesses effectiveness elearning teaching learning processes main challenge improve current pass rates wsu hence research aims investigate student attitudes perceptions well effectiveness using wiseup elearning system teaching learning processes wsu action research process evaluated end implementation cycle active students registered two courses whereby questionnaire distributed identify views perceptions experiences challenges benefits system however believed globalisation need modernisation calling better quality education application accessibility elearning could speed process transforming education also understanding students attitudes toward elearning significant improving elearning usage results wsu
many large scale machine learning problems clustering non parametric learning kernel machines etc require selecting small yet representative subset large dataset problems often reduced maximizing submodular set function subject various constraints classical approaches submodular optimization require centralized access full dataset impractical truly large scale problems paper consider problem submodular function maximization distributed fashion develop simple two stage protocol greedi easily implemented using mapreduce style computations theoretically analyze approach show certain natural conditions performance close centralized approach achieved begin monotone submodular maximization subject cardinality constraint extend approach obtain approximation guarantees necessarily monotone submodular maximization subject general constraints including matroid knapsack constraints extensive experiments demonstrate effectiveness approach several applications including sparse gaussian process inference exemplar based clustering tens millions examples using hadoop
many large scale online services use structured storage persist metadata sometimes data structured storage typically provided standard database servers microsoft sql server important understand workloads seen servers provisioning server hardware well exploit opportunities energy savings server consolidation paper analyze disk traces production servers four internet services well servers running tpc benchmarks show using range load metrics services differ substantially standard tpc benchmarks online services also show significant diurnal patterns load exploited energy savings consolidation argue tpc benchmarks capture important characteristics argue developing benchmarks parameterized workload features extracted live production workload traces
many problems computer vision visualization lead system linear equations fast robust solution required vast majority computational problems computer vision visualization computer graphics three dimensional principle paper presents equivalence cross product operation solution system linear equations using projective space representation homogeneous coordinates leads conclusion division operation solution system linear equations required projective representation homogeneous coordinates used efficient solution cpu gpu based architectures presented application barycentric coordinates computation well
many psychology applications assess measurement invariance construct depression time applications often characterized time points high rates dropout although applications routinely assume dropout mechanism ignorable assumption may always reasonable presence nonignorable dropout fitting conventional longitudinal factor model lfm assess longitudinal measurement invariance yield misleading inferences level invariance along biased parameter estimates article develop pattern mixture longitudinal factor models lfms quantifying uncertainty longitudinal invariance testing due unknown potentially nonignorable dropout mechanism lfms kind multiple group model wherein observed missingness patterns define groups lfm parameters differ across pattern groups subject identification constraints marginal inference longitudinal invariance obtained pooling across pattern groups dropout nonignorable demonstrate via simulation conventional lfms indicate longitudinal noninvariance even invariance holds overall population certain lfms shown ameliorate problem hand dropout ignorable lfms shown provide results comparable conventional lfms additionally contrast lfms latent mixture approach accommodating nonignorable dropoutwherein missingness patterns differ across latent groups empirical example assessing longitudinal invariance harsh parenting construct employ lfms assess sensitivity results assumptions nonignorable missingness software implementation recommendations practice discussed
many real world complex systems naturally map network data structures instead geometric spaces available information presence absence link two entities system enable data mining techniques solve problems network domain nodes need mapped geometric space propose mapping representing network node geodesic distances nodes space spanned geodesic distance vectors geodesic space network position different nodes geodesic space encode network structure space considering continuous density field induced node density specific point summation density fields induced nodes drift node direction positive density gradient using iterative algorithm till node reaches local maximum due network structure captured space nodes drift region space belong communities original network use direction movement final position node important clues community membership assignment proposed algorithmis compared state art community detection techniques two benchmark networks known communities using normalized mutual information criterion proposed algorithm outperformed methods significant margin moreover proposed algorithm also shown excellent performance many real world networks
many reverse engineering techniques data structures rely knowledge memory allocation routines typically interpose system malloc free functions track chunk memory thus allocated data structure however many performance critical applications implement custom memory allocators examples include webservers database management systems compilers like gcc clang result current binary analysis techniques tracking data structures fail binaries present membrush new tool detect memory allocation deallocation functions stripped binaries high accuracy evaluated technique large number real world applications use custom memory allocators demonstrate membrush detect allocators deallocators high accuracy allocators deallocators specint show furnish existing reverse engineering tools detailed information memory management api result perform analysis actual application specific data structures designed programmer system uses dynamic analysis detects memory allocation deallocation routines searching functions comply set generic characteristics allocators deallocators
many species face trade additional mating opportunities offspring benefits viability quality provided parental care female holocnemus pluchei spiders must abandon egg sac otherwise carry chelicerae copulate may involve risks offspring predation fungal infection assessed whether males discriminate egg carrying females according egg development stage females influenced egg development stage regard proneness tomate offspring less likely survive due high humidity predation absence egg carrying females apparently males distinguish females according developmental stage eggs carried however females likely mate carrying relatively mature versus immature eggs days days post oviposition respectively egg sacs hatched successfully guarded egg carrying females avoided fungal infections high humidity cannibalism conspecific spiders thus pluchei females may face trade mating parental care research clarify eggcarrying females mate females prevent egg sacs infected fungi
many studies investigated seasonal affective disorder sad fall winter depression treatment light therapy however best knowledge study investigated usage europe since thus performed survey hospitals adult psychiatric departments german speaking countries questionnaire first questionnaire constructed considering also recent developments questionnaire sent hospitals adult psychiatric departments listed deutsches krankenhaus adressbuch contains hospitals german speaking countries germany switzerland austria non responders asked answer questionnaire mail phone achieved completion rate data show almost relevant non artificial differences countries well type hospital frequently used university state hospitals types treatment facilities compared major findings substantial increase use differences germany austria switzerland increase mostly due treatment various forms depression possible applications less often considered shift usage monotherapy combination pharmacotherapy adjunctive treatment north south comparison showed substantial differences considerably higher rates usage found compared last survey german speaking countries taking place usage almost tripled however possible indications sad non seasonal depression applied full extent efforts propagation therefore undertaken rigorous studies pharmacotherapy
many studies investigated whether type antipsychotics type adjuvant associated smoking reduction patients schizophrenia however study exploring comprehensive range factors related smoking reduction schizophrenia patients analyzed dataset smoking patients schizophrenia participated week open label study high low dose nicotine dermal patches bupropion logistic regression model linear mixed model used explore factors associated outcomes smoking cessation reduction number cigarettes smoked level nicotine dependence total cessation rate significant predictors cessation time effect reduction significant program type antipsychotics readiness quit baseline number cigarettes smoked per day nicotine dependence level significantly associated smoking reduction patients first generation antipsychotics clozapine reduced smoking non clozapine second generation antipsychotics patients preparation stage contemplation reduced smoking precontemplation stage mechanisms tobacco addiction need better understood development effective cessation programs patients schizophrenia
many studies seemingly demonstrated anonymous individuals shown artificial cues watched behave watched real people however several studies failed replicate surveillance cue effect light mixed results conducted two meta analyses investigating effect artificial observation cues generosity overall meta analyses found evidence support claim artificial surveillance cues increase generosity either increasing generous individuals increasing probability individuals show generosity therefore surveillance cue effects interpreted cautiously elsevier inc rights reserved
many technological bottlenecks prevent realizing software radio mobile terminal old way building radio architectures single handled terminal address various communication standards paper exposes receiver sampled analog signal processor sasp designed perform downconversion channel presorting idea process analog voltage samples order recover baseband signal emitted ghz analog fast fourier transform achieves frequency shifting filtering experimental demonstrator sasp using cmos technology stmicroelectronics presented measured validates concept new receiver design demonstrator runs ghz consuming
many typically developing siblings provide care siblings autism spectrum disorder asd children adults research parentification children assume responsibilities typically reserved adults mixed studies supporting positive outcomes siblings others indicating negative outcomes discrepancies may due inconsistencies differentiating types parentification current study examined different types parentification childhood retrospectively reported related distress outcomes attitudes sibling relationships among adult siblings individuals asd results indicated parent focused parentification positively related anxiety stress among siblings sibling focused parentification positively related stress also related positive sibling relationship attitudes accounting demographic variables form parentification parent focused parentification unique predictor distress whereas sibling focused parentification unique predictor positive sibling relationship attitudes although parentification often viewed negatively sibling focused parentification perceived benefits parentification may predict positive outcomes results suggest parentification may prove important understanding complex nature sibling relationships specifically strengthening sibling bond reducing parent focused parentification childhood may curtail sibling relationship problems general distress siblings later life
many colleges universities adopting cloud computing may defined distributed computing system provides access virtual resources including computer hardware networks software development platforms memory site location accessed locally thus far development driven primarily hope administrative benefits cloud also presents excellent opportunities chemical educators moving cloud allow every student class access resources necessary class simply accepting invitation join site encourages collaboration development new educational models
many vocational schools universities offer lectures non stereoscopic computer graphics dcg animation production well practical dcg software operation modeling animation production however relatively educational institutions provide lectures stereoscopic address gap developed two week syllabuses educational materials focused knowledge based skills based education dcg animation computer graphics sdcg animation production considering potential employment students animation studios investigation confirmed knowledge skills subjects improved study presented report effectiveness educational materials sdcg animation production education education symposium siggraph asia developing educational materials reaffirmed importance camerawork skills education may regarded cornerstone dcg animation sdcg animation production however camerawork skills education dcg animation classes remains limited vocational schools universities present hypothesized one reasons paucity camerawork skills education lack suitable educational materials practical classes use dcg software indeed educational materials allow teachers begin camerawork skills education dcg sdcg animation production without preparation greatly lacking furthermore modeling character animation regarded essential camerawork practice camerawork practice started immediately sufficient educational materials provided educational materials developed suitable sdcg also dcg camerawork practice study present camerawork skills education evaluation methods involved educational materials developed lectures camerawork practical classes sdcg animation discuss experimental classes used educational materials report results knowledge tests camerawork practical tests conducted order measure learning education outcomes participating subjects well results survey focused subjective experiences experimental results clearly demonstrated improvements knowledge skills subjects thereby confirming effectiveness camerawork educational materials suggest students knowledge dcg animation well practiced use educational materials skills sdcg camerawork would improve markedly elsevier ltd rights reserved
mapping structure entropy region least four jointly distributed random variables important open problem even partial knowledge region far reaching consequences areas mathematics like information theory cryptography probability theory combinatorics presently known method exploring entropy region equivalent one zhang yeung using non trivial properties entropy function method transformed solving high dimensional linear multiobjective optimization problems benson outer approximation algorithm fundamental tool solving optimization problems improved version benson algorithm presented requires solving one scalar linear program iteration rather two three previous versions algorithm design special care taken numerical stability implemented algorithm used verify previous statements entropy region well explore experimental results demonstrate viability improved benson algorithm determining extremal set medium sized numerically ill posed optimization problems larger problem sizes two limitations benson algorithm observed inefficiency scalar solver unexpectedly large number intermediate vertices
mapreduce widely used distributed computing framework due excellent parallelism scalability dealing large scale data one important research point distributed computing field improve performance mapreduce application datacenter network openflow protocol makes possible schedule network resource dynamically provide better link bandwidth shuffle traffic current openflow based scheduling method runs single controller meet needs excessive switch requests large scale data center networks performance scheduling method decrease obviously due conflict problem run distributed controllers paper proposed dscheduler dynamic network scheduling method distributed controllers dscheduler running application sdn controller avoid majority conflict problems scheduling small cost using lock communication controller implement prototype system floodlight demonstrate design test performance experimental results show dscheduler significant effect decreasing occurrence times conflict situations improving performance openflow based scheduling method distributed controllers
marihuana widely consumed illicit drug even among adolescents pregnant women given critical developmental processes occur adolescent fetal nervous system marihuana consumption stages may permanent consequences several brain functions later adult life review currently known long term consequences perinatal adolescent cannabinoid exposure consistent findings point long term impairments cognitive function associated structural alterations disturbed synaptic plasticity addition several neurochemical modifications also evident prenatal adolescent cannabinoid exposure especially endocannabinoid glutamatergic dopaminergic opioidergic systems important sexual dimorphisms also evident terms long lasting effects cannabinoid consumption pregnancy adolescence cannabinoids possibly protective effect adolescents suffered traumatic life challenges maternal separation intense stress finally suggest future research directions may encourage advances exciting field elsevier ltd rights reserved
masonry walls subjected plane loading exhibit complex behavior influence several parameters axial load aspect ratio strength materials high rise buildings seismic areas large tensile stresses may arise walls vertical horizontal reinforcement often used provide proper resistance increases complexity structural behavior work presents overview experimental behavior unreinforced reinforced masonry walls overview distinct design methods aimed calculating plane lateral resistance proposal new design model reinforced masonry walls subjected plane loading proposed model considers coupling interaction flexural shear resisting mechanisms updates role vertical horizontal reinforcement lateral resistance database composed experimental results plane lateral resistance masonry walls available literature used evaluate performance existing models validate newly proposed model exhibits much better performance doi asce american society civil engineers
massive public pressure arising achieve data privacy protection one way maintain data privacy perform efficient data disposal processes minimizes chances data leakage extended period irresponsible actions adequate data disposal essential many governmental critical institutions simply deleting data erase fact removes name refers piece data data remains paper utilize encryption algorithm perform randomization process dispose data values irreversible approach making difficult retrieve original value data defaced result
mast cells tissue resident cells innate immunity implicated pathogenesis many autoimmune diseases including rheumatoid arthritis present synovia activation linked potentiation inflammation course however recent investigations questioned role ofmast cells arthritis particular animal models generated conflicting results many pro inflammatory pro arthritogenic functions even though supported robust experimental evidence labelled redundant time growing body evidence suggests mast cells act tunable immunomodulatory cells characteristics yet fully understood context could partially explain inconsistent results obtained experimental models account pro anti inflammatory functions exerted chronic heterogeneous conditions present overview current knowledge mast cell involvement including intriguing hypothesis mast cells acting subtle immunomodulatory cells emerging concept synovial mast cells potential biomarkers patient stratification elsevier rights reserved
materials adjust properties response environmental factors temperature ionic strength rapidly evolving known smart materials hydrogels formed smart polymers various applications among smart polymers thermoresponsive polymer poly isopropylacrylamide pnipam important well defined structure property specially temperature response closed human body finetuned well mechanical properties critical performance stimuli responsive hydrogels diverse applications however native pnipam hydrogels fragile hardly useful practical purpose intense researches done recent decade enhance mechanical features pnipam hydrogel review several strategies including interpenetrating polymer network ipn double network nanocomposite slide ring hydrogels discussed context pnipam hydrogel elsevier rights reserved
maternal mammalian toxicity impacts prenatal development general systemic maternal toxicity reduced weight gain morbidity causative reduced fetal weights litter increased fetal variations especially skeletal litter author opinion increased fetal malformations reduced litter sizes full litter losses increased fetal malformations likely due exposure specific chemicals alter specific maternal functions critical point pregnancy typically exaggerated effects higher doses drugs development known desired pharmacological effects malformations also genetic epigenetic alterations specific altered proteins molecular pathways etc full litter losses triggered mother rare rats information inform maternal developmental toxicity includes ovarian corpora lutea counts uterine implantation profile degree litter reduction present timing extent maternal toxicity relative adverse embryofetal effects etc view maternal toxicity confounding results vivo developmental toxicity studies worldwide concerns increased research animal usage increasing time labor costs new software hardware sophistication drive interest development validation performance vitro silico assays assays fast inexpensive responsive animal use concerns amenable mechanistic questions strength vitro silico assays considered many absence maternal organism placenta assays inform mechanism hazard risk environmental protection agency currently estimates new assays approximately accurate versus whole animal tests birth defects res part wiley periodicals inc
maximum consensus one popular criteria robust estimation computer vision despite widespread use optimising criterion still customarily done randomised sample test techniques guarantee optimality result several globally optimal algorithms exist slow challenge dominance randomised methods work aims change state affairs proposing efficient algorithm global maximisation consensus framework type methods show consensus maximisation wide variety vision tasks posed tree search problem insight leads novel algorithm based search propose efficient heuristic support set updating routines enable search efficiently find globally optimal results common estimation problems algorithm much faster previous exact methods work identifies promising direction globally optimal consensus maximisation
mayas experienced genocide exile severe poverty high risk consequences cumulative trauma continually resurfaces current fear uncertain future little known mental health alcohol use status population correlational study explored relationship cumulative trauma relates social determinants health years united states education health insurance status marital status employment psychological health depression symptoms health behaviors alcohol use guatemalan mayas living southeast florida results study indicated specific social determinants health cumulative trauma increased depression symptoms particularly among women risk harmful alcohol use particularly among men increased identifying risk factors early stage serious disease problems manifest provides room early screening leading early identification early treatment better outcomes
measured signals obtained sensors dynamic events earthquake wind wave contain nonlinear nonstationary noisy properties paper new approach presented modal parameter identification structures particularly suitable large real life structures super high rise building structures based integration discretized synchrosqueezed wavelet transform hilbert transform linear least square fit effectiveness demonstrated first application two dimensional frames literature story lotte world tower lwt construction seoul korea lwt measurements low amplitude ambient vibrations extracting natural frequencies damping ratios low amplitude signals known challenging new methodology compared empirical mode decomposition demonstrated new method capable extracting natural frequencies damping rations low amplitude signals effectively higher accuracy compared empirical mode decomposition approach results research indicate super high rise building like lwt damping ratio range new method quite promising practical implementations health monitoring large real life structures
measurement impact influence medical scientific journals individual researchers become widely practiced recent decades tills driven part increased availability data regarding citations research articles increased competition research funding digestive disease research identified particularly strong discipline canada authors collected quantitative data impact influence canadian digestive health research present study involved analysis research impact hirsch factor research influence influence factor digestive health researchers canada rankings top researchers basis two metrics dominated larger research groups university toronto toronto ontario mcmaster university hamilton ontario universities calgary calgary alberta alberta edmonton alberta representation research groups universities manitoba winnipeg manitoba western ontario london ontario mcgill university montreal quebec female male researchers similar scores two metrics basic scientists versus clinical investigators strategic recruitment particularly established investigators major impact ranking research groups comparing metrics different time frames provide insights vulnerabilities strengths research groups
measuring estimating number errors violations functional dependency offers valuable information data semantics quality existing work focuses error estimation centralized environment data stored one site goal optimize time space complexities estimation algorithms distributed error estimation problem data reside multiple physically distributed sites never studied depth subject work work study version distributed error estimation problem coordinator site communicates multiple remote sites arriving estimations goal minimize communication cost study two types queries dual semantics estimations one tries maximize accuracies error estimations fixed communication costs minimize communication costs needed meet certain accuracy requirements framework remote site maintains concise synopsis data structure obtained scanning local data coordinator site receives processes data structures arrive estimate error solution extends case two remote sites multiple remote sites demonstrate efficacy proposed techniques via rigorous analysis extensive experiments elsevier inc rights reserved
mechanical models tumor growth used extensively recent years analysis medical observations prediction cancer evolution based image analysis work deals numerical approximation mechanical model tumor growth analysis dynamics system investigation given multi phase flow model densities different cells governed transport equation evolution tumor cells whereas velocity field given brinkman regularization classical darcy law efficient finite difference scheme proposed shown converge weak solution system approach relies convergence compactness arguments spirit lions lions mathematical topics fluid mechanics vol vol oxford lecture series math appl clarendon press oxford university press new york
mechanical surface treatment methods shot peening may improve fatigue strength materials study effect shot peening strain controlled constant amplitude fatigue loading near pearlitic microalloyed steel investigated stress amplitudes throughout whole lifetime followed addition detailed recording stress strain hysteresis loops particularly small cycle numbers detailed relaxation residual stresses changes full width half maximum fwhm ray peak surface depth function number cycles plastic strain recorded techniques onset well rate relaxation residual stresses could followed different strain amplitudes pronounced increase lifetime shot peened specimens tested total strain amplitude smaller corresponding plastic strain amplitude achieved coincides reasonably stable residual stresses surface depth elsevier rights reserved
mechanics materials structures become popular new name former institutes strength materials structural analysis european universities technology designation stands scientific program aimed symbiosis material structural mechanics adjective computational refers algorithmic component mechanics materials structures frequently underrated advent digital computer opened door computational mechanics become scientific discipline tremendous influence lives survey paper contains report selection recent research projects carried institute mechanics materials structures vienna university technology aim demonstrate trinity computational mechanics materials structures strong impact modern life elsevier ltd rights reserved
mechanism design study algorithm design inputs algorithm controlled strategic agents must incentivized faithfully report unlike typical programmatic properties sufficient algorithms merely satisfy property incentive properties useful strategic agents also believe fact verification attractive way convince agents incentive properties actually hold mechanism design poses several unique challenges interesting properties sophisticated relational properties probabilistic computations involving expected values mechanisms may rely probabilistic properties like differential privacy achieve goals introduce relational refinement type system called hoare verifying mechanism design differential privacy show hoare sound denotational semantics correctly models epsilon delta differential privacy moreover show subsumes dfuzz existing linear dependent type system differential privacy finally develop smt based implementation hoare use verify challenging examples mechanism design including auctions aggregative games new proposed examples differential privacy
media violence exposure causes increased aggression decreased prosocial behavior suggesting media violence desensitizes people emotional experience others alterations emotional face processing following exposure media violence may result desensitization others emotional states study used scalp electroencephalography methods examine link exposure violence neural changes associated emotional face processing twenty five participants shown violent nonviolent film clip completed gender discrimination stop signal task using emotional faces media violence affect early visual component however decreased amplitude observed event related potentials following violent film indicating exposure film violence leads suppression holistic face processing implicit emotional processing participants seen violent film showed increased frontal amplitude results suggest media violence exposure may desensitize people emotional stimuli thereby require fewer cognitive resources inhibit behavior
media diverse forms become powerful tool construction portrayal shoulds oughts musts woman body result thinning beauty ideals media real woman finds representations ideal woman increasingly unattainable exploratory study examined effect acute media images sample young adult indian woman intervention group time mixed group design used half participants presented thin ideal media images whereas half presented control images participants examined body image dissatisfaction thin ideal internalization self esteem results study indicate significant increase thin ideal internalization body dissatisfaction significant decrease self esteem scores result exposure thin ideal media images findings study indicate similar counterparts europe north america young urban indian women experience body image disturbances exposed thin ideal images findings examined light spread global media homogenization beauty standards among non western countries
median filtering canonical image processing operation truly useful many practical applications appealing feature resistance noise errors data method requires window values sorted computationally expensive work new insight capabilities based optimal breakdown value median offered also shown based versions two popular algorithms outperform corresponding standard versions general framework theoretical analysis comparison algorithms presented process hopefully contribute better understanding many subtle features introduced ideas experimentally tested using real synthetic images
medical additive manufacturing requires standard tessellation language stl models models commonly derived computed tomography images using thresholding threshold selection performed manually automatically aim study assess impact manual default threshold selection reliability accuracy skull stl models using different technologies one female one male human cadaver head imaged using multi detector row dual energy two cone beam scanners four medical engineers manually thresholded bony structures images lowest highest selected mean threshold values default threshold value used generate skull stl models geometric variations manually thresholded stl models calculated furthermore order calculate accuracy manually default thresholded stl models stl models superimposed optical scan dry female male skulls gold standard intra inter observer variability manual threshold selection good intra class correlation coefficients engineers selected grey values closer soft tissue compensate bone voids geometric variations manually thresholded stl models multi detector row dual energy cone beam stl models demonstrated inaccuracies ranging multi detector row dual energy cone beam study demonstrates manual threshold selection results better stl models default thresholding use dual energy cone beam technology present form deliver reliable accurate stl models medical additive manufacturing new approaches required based pattern recognition machine learning algorithms
medical case management improved past decades changing dynamic interaction depression prevalent medical diseases relevant describe comorbidity depression medical diseases improve effectiveness case management analyzed data adults aged years older completed depression screening part national health nutrition examination survey depression ascertained using patient health questionnaire item screening instrument asking frequency depression symptoms past weeks comorbid diseases assessed self reported personal interview doctor diagnosed health conditions associations depression medical diseases limited diseases painful somatic symptoms reported men women arthritis prevalent chronic disease one consistently associated depression odds ratio moderate severe depression confidence interval men women arthritis compared counterparts free arthritis moderate severe depression associated history heart disease among men angina angina pectoris among women associations found depression cancer malignancy either among men women potential impact pain management depression prevention among general population substantial efforts needed assess chronic pain facilitate timely prevention treatment depression comorbid medical conditions
medical cyber physical systems mcps monitor control patients physiologic dynamics embedded distributed computing process wireless wired communication network mcps greatly impact society high quality medical services low cost ubiquitous healthcare major component integrates physical world cyber space wireless body area network wban medical sensors actuators worn implanted patient life critical nature mcps mandates safe effective system design mcps must operate safely malicious attacks authentication ensures medical device claims declares first line mcps defense traditional authentication mechanisms relied cryptography applicable mcps constraints computing communication energy resources recent innovations secure mobile wireless sensor networks multi sensor fusion save power consumption adequate besides challenges mcps present grand opportunities unique physical features wban non cryptographic authentication human aided security paper proposes authentication framework mcps studying medical processes investigating healthcare adversaries novel design crosses physical world cyber space uneven resource allocation resource scarce wban utilizes encryption authentication evaluation authentication protocol shows promising aspects ease adaptability copyright john wiley sons ltd
medical imaging deals visualising internal structures human body diagnose treat diseases several image processing schemes algorithms introduced overcome challenges regarding medical image analysis paper cubic trigonometric spline scheme multiple quality control parameters proposed medical image processing comparison proposed scheme found better conventional bilinear bicubic image processing techniques terms peak signal noise ratio root mean square error structural similarity index measure
melanoma potentially lethal skin cancer high mortality rate recently peptide mediated transdermal delivery small interference rna sirna emerges promising strategy treat melanoma inducing apoptosis tumor cells related theoretical model describing delivery sirna effect space egf growth inhibition melanoma dynamic expanding bump skin due growth melanoma reported yet article theoretical model developed describe percutaneous sirna delivery mediated space egf melanoma growth inhibition melanoma results present spatial temporal distribution sirna growth melanoma inhibition sirna shows good consistency experimental results addition model represents uplift process tumors skin surface model presented useful tool understand whole process space egf mediated delivery sirna melanoma skin predict therapeutic effect optimize therapeutic strategy providing valuable references treatment melanoma
melt processing routinely used fabricate medical polymeric devices implants clinical reconstruction incorporated quality systems procedures medical device manufacture additive manufacturing becomes increasingly used biomaterials biofabrication translation new customizable medical devices clinic becomes paramount melt processing therefore distinguishable group withinamthat provides avenue manufacture scaffolds implants clinical end point three key melt processingam technologies highlighted review melt micro extrusion selective laser sintering melt electrospinning writing vivo including clinical outcomes medical devices scaffolds made processes reviewed together encompass meltamof scaffold architectures feature sizes resolutions ranging nmup
members knowledge translation exchange kte research team assessed training needs teaching staff school individuals intellectual developmental disabilities idd response need kte researchers retrieved peer reviewed articles training staff working individuals idd exhibit challenging behaviours articles categorised according following training content interventions designed reduce frequency challenging behaviours appropriate ways manage challenging behaviours moment promote safety parties terminate ongoing behaviour procedures perspectives relevant coping ameliorating negative impacts challenging behaviours staff examined training methods teaching strategies training duration involved teaching content assessed effectiveness programmes overall found effective training programmes consisted workshops practica feedback specific skill performance forms brief training effective increasing staffs knowledge skills reducing frequency challenging behaviour
mental health screening assessment crucial within juvenile correctional facilities however limited information available current screening assessment procedures specifically within purpose current study obtain information mental health screening assessment procedures used throughout united states ninety four clinical staff members one completed survey mental health screening assessment procedures conducted facilities used descriptive statistics obtain prevalence data screened assessed frequency screening assessment methods used areas screened assessed qualifications conducting screenings assessments perceived adequacy screening procedures ninety eight percent participants reported facilities conducted suicide risk screenings reported mental health screenings conducted admission youth additionally respondents reported youth receive extensive assessment mental health concerns however forty six percent participants responding indicated repeated screening youth throughout stay participants responding indicated screening discharge additionally variety assessments reportedly used little consistency across findings revealed continued need consistent policies procedures across facilities regarding screening assessment address various screening assessment issues promote quality care
metabolic acidosis common advanced chronic kidney disease associated range physiological derangements importance health older people include associations skeletal muscle weakness cardiovascular risk factors bone mineral disorders may lead fragility fractures although metabolic acidosis associated accelerated decline kidney function end stage renal failure much less common outcome older frail patients cardiovascular death correction metabolic acidosis using bicarbonate therapy commonly employed existing evidence insufficient know whether therapy net benefit older people bicarbonate bulky awkward take may impose additional sodium load effects fluid retention blood pressure may cause gastrointestinal side effects trial data date suggest potential benefits bicarbonate therapy progression renal disease nutrition trials yet published examining effect bicarbonate therapy across range domains relevant health older people fortunately number trials underway allow ascertain whether bicarbonate therapy improve physical function quality life vascular bone kidney health older people hence decide whether benefits seen outweigh adverse effects additional treatment burden vulnerable group patients
metaheuristic algorithms mhs long history traced back genetic algorithms evolutionary computing since february birth firefly algorithm mhs started receive attention researchers around globe variants new species algorithms bloomed like sprouts rain however necessity creating new species algorithms questionable observed algorithms fundamentally made several widely used core components explaining components underlying design collection called modern optimisation algorithms revealed paper core components popular algorithms reviewed thereby debunking myths novelty perhaps dampening claims something really new invented simply branding search method name another living creature counterintuitive experimentations shown taking snapshots anyone show improvements another situation mixing certain components indeed adds advantage original goes extending slight functional modification work also serves general guideline reference algorithm architect wants create new algorithm future
metal transport process plants determinant quality quantity harvest although among important staple crops knowledge genes encode membrane bound metal transporters scarce wheat metal tolerance proteins mtps involved trace metal homeostasis sub cellular level usually providing metal efflux cytosol using various bioinformatics approaches genes encode mtps hexaploid wheat genome triticum aestivum abbreviated identified characterized based comparison known rice mtps wheat genome contained mtp sequences named tamtp tamtps contained cation diffusion facilitator cdf family domain members harbored zinc transporter dimerization domain based motif phylogeny alignment analysis genomes tamtp sequences demonstrated higher homology compared tamtp reference rice orthologs tamtps tamtps belonged cdfs tamtps cdfs tamtp cdfs upstream regions tamtp genes included diverse cis regulatory motifs indicating regulation developmental stage tissue type stresses scan coding sequences tamtps published mirnas predicted total potential mirnas mainly targeting members diverged groups expression analysis showed several tamtps temporally spatially regulated developmental time course grains mtps preferentially expressed aleurone layer known reservoir high concentrations iron zinc work identified characterized metal tolerance proteins common wheat revealed potential involvement mtps providing sink trace element storage wheat grains
metallurgical industry appreciated advantages continuous casting machines producing variety high quality products made steel special alloys design features horizontal continuous casting machines makes possible use type machines mini plants annual productivity lower hundreds thousands tons end products paper examines construction continuous casting machines horizontal type principles operation modern continuous casting machines intended production billets made carbon quality steels special alloys diameter describes basic requirements withdrawal device operation cycle experimental data analysis conducted revealing different combinations basic parameters casting cycle influence electric motor equivalent torque based results trial operation mechanism improvement withdrawal controls methods proposed
metamaterials years development various fields shows unique charm paper based fss random distributed patches combined digital camouflage proposes model processing realize multiband stealth realization reserved digital camouflage visible light stealth performance also fss microwave frequency band stealth effect concluded corresponding simulation results counter multiband detection fusion type fss provides effective method
metamaterials surprisingly broadened range available practical applications new devices shielding microwave absorbing novel antennas research conducted related tuning dng frequency bands ordered disordered metamaterials far less research focused importance impedance matching behavior little effort attention given adjusting magnitude negative permittivity values particularly important devices deal low amplitude signals radio antennas carbon hafnium nickel oxide nanocomposites simultaneously negative permittivity negative permeability excellent metamaterial performance good impedance matching could become efficient alternative ordered metamaterials wave transparent microwave absorbing solar energy harvesting fields study prepared nanocomposites solvothermal method clarified impedance matching double negative dng behaviors tuned external electric field created electric quadrupole system external electric field allows alignment well dispersed nanoparticles carbon long range orientations order believe finding broadens understanding moderate conductive material based random metamaterials mcmrms provides novel strategy replacing high loss ordered disordered metamaterials mcmrms
methicillin resistant staphylococcus aureus mrsa vancomycin resistant enterococcus faecalis vre notorious pathogenic multidrug resistant mdr bacteria hospital community sectors today first antibacterial drug sulfamethoxazole ineffective monoterpene phenol thymol conjugated seven sulfa drug derivatives individually adopting dye azo synthesis protocol conjugates characterized using spectral analysis techniques ftir hplc nmr nmr sem conjugates assessed antibacterial activity vitro silico zone inhibition mic mbc values conjugate determined isolated mrsa vre strains clinical samples dimentional structures dihydropteroate synthases dhpss targeted bacteria available protein database homology models dhps enzymes bacteria generated validated ramachandran plots seven conjugates used ligands molecular docking mrsa dhps vre dhps additionally bioinformatics tools pass prediction lipinski rules five computational value toxicity class homo lumo eps plots carried assess standard drug likeliness properties conjugates zone size inhibition conjugate thymol sulfadiazine mrsa vre strains agar plates lowest mic mbc values respectively reference antibiotic ampicillin lowest mic mbc values vitro host toxicity testing carried cultured human lymphocytes umbilical cord blood broadly non toxic human cells thus could promoted newer antibacterial gruesome mdr bacteria elsevier masson sas rights reserved
methiozolin new herbicide control annual bluegrass poa annua large crabgrass digitaria sanguinalis scop various turfgrasses potential methiozolin induce maternal developmental toxicity investigated pregnant new zealand white rabbits methiozolin dose levels day administered oral gavage artificially inseminated rabbits females per group days gestation subjected cesarean section day gestation day treatment related toxicities including abortion decreased mean body weight weight gain net body weight change reduced food consumption decreased fetal weight observed day signs maternal developmental toxicity observed treatment related external visceral skeletal abnormalities fetuses doses tested current experimental conditions observed adverse effect levels noaels methiozolin considered day prenatal development published elsevier inc
method moment used calculate vertical tail radar cross section rcs impact leading edge sweep angle span inclination vertical tail rcs analyzed vertical tail rcs curves function expressions leading edge sweep angle span inclination fitted calculation results results show optimizing vertical tail leading edge sweep angle span inclination geometrical parameters improve stealth performance vertical tail optimize design vertical tail stealth provide technical foundation
methods described create accurate sub sets user data introducing dead bands data clusters user data collected mined produces clusters data dead bands generated delineate describe data clusters accurately accomplished classifying data inside newly created dead bands either two clusters example three clusters generated two two yes another set know introduced new set improves precision choices made using data yes clusters dead bands introduced establishing radius corners shapes containing clusters establishing horizontal vertical line parallel edges radius edge encompasses user data nearest corner edge data set outside excluded original set lines overlap dead band created contain user data confident increases likelihood accurate decisions made new sets user data case studies described demonstrate
methods study based semi structured qualitative interviews policy makers senior health care managers two russian regions review published unpublished sources health systems hiv russia findings identified number factors associated system failure address epidemic argue factors unique hiv aids features wider health system within hiv response set influenced structure capacities programme particularly regulatory clinical orientation discrepancy formal commitments implementation focus screening services problems scaling interventions targeting high risk groups discussion system programme interplay important middle income countries poorer settings advanced health care infrastructure protect health systems potential failures delivery vertical programmes hiv response effective efficient responsive needs population broader health system adhere principles strengthening hiv responses post soviet societies require improvements wider health systems namely advocacy prevention high risk populations reallocation resources curative towards preventive services building decision making capacities local level developing better working environments health care staff
methods use derivative information becoming popular among researchers since allow solve many real world engineering problems problems frequently characterized presence discrete variables complicate optimization process paper propose derivative free algorithms solving continuously differentiable mixed integer nonlinear programming problems general nonlinear constraints explicit handling bound constraints problem variables use exterior penalty approach handle general nonlinear constraints local search approach take account presence discrete variables show proposed algorithms globally converge points satisfying different necessary optimality conditions report computational experience comparison well known derivative free optimization software package nomad set test problems furthermore employ proposed methods nomad solve real problem concerning optimal design industrial electric motor allows show method converging better extended stationary points obtains best solution also applicative point view
methylphenidate mph abuse cause serious neurological damages neuroprotective effects topiramate tpm reported already mechanism action still remains unclear current study evaluates vivo role creb bdnf tpm protection rat hippocampal cells methylphenidate induced apoptosis oxidative stress inflammation total adult male rats divided six groups groups received normal saline rat mph respectively days groups concurrently treated mph tpm respectively days groups treated tpm respectively drug administration open field test oft used investigate motor activity hippocampus isolated apoptotic antiapoptotic oxidative antioxidant inflammatory factors measured expression total phosphorylated creb bdnf gene protein levels gene expression camk mapk pka fos levels also measured mph significantly decreased motor activity oft tpm decreased mph induced motor activity disturbance additionally mph significantly increased bax protein level camk gene expression lipid peroxidation catalase activity mitochondrial gsh beta tnf alpha levels isolated hippocampal cells also creb total phosphorylated forms bdnf bcl protein levels mapk pka fos gene expression superoxide dismutase glutathione peroxidase glutathione reductase activities decreased significantly mph tpm presence absence mph attenuated effects mph immunohistochemistry data showed tpm increased localization total phosphorylated forms creb dentate gyrus areas hippocampus seems tpm used neuroprotective agent apoptosis oxidative stress neuroinflammation induced frequent use mph might probably mediated creb bdnf upstream signaling pathways
order disorder lattice dynamics orthorhombic pseudobrookite type mgti studied experiment modeling mechanochemical activation high speed ball milling allowed synthesize pure mgti mgo tio anatase comparatively low temperature order mgtio characterized ray diffraction raman spectroscopy density functional theory calculations based fully ordered mgtio allow assignment experimentally observed raman infrared modes evaluation earlier findings standard entropy mol bulk modulus gpa predicted fully ordered mgtio good agreement experimental findings based quasi adiabatic calorimetry samples different ordering states earlier high pressure studies respectively linear relation big raman blue shift disorder observed used rapidly quantify ordering state mgtio elsevier rights reserved
mhd free convection inclined plate thermally stratified high porous medium presence magnetic field studied dimensionless momentum temperature equations solved numerically explicit finite difference technique help computer programming language compaq visual fortran obtained results studies discussed different values well known parameters different time steps also stability conditions convergence criteria explicit finite difference scheme analyzed finding restriction values various parameters get accuracy effects various governing parameters fluid velocity temperature local average shear stress nusselt number investigated presented graphically
microalgae accepted promising feedstock biodiesel production owing capability converting solar energy lipids photosynthesis however high capital operating costs high energy consumption hampering commercialization microalgal biodiesel study surface floating microalga strain avff tentatively identified botryosphaerella sudetica naturally forms biofilm surfaces characterized use biodiesel production biofilm could conveniently harvested surface water adsorbing onto polyethylene film lipid productivity strain avff day allowing direct comparison lipid productivities microalgal species moisture content surface floating biomass much lower biomass harvested using centrifugation results reveal potential surface floating microalgal species biodiesel producer employing novel biomass harvesting dewatering strategy society biotechnology japan rights reserved
microbial fuel cells mfcs novel bio electrochemical device spontaneous single step conversion biomass electricity based use metabolic activity bacteria design use mfcs attracted considerable interests potential new opportunities offer sustainable production energy biodegradable reused waste materials however associated slow microbial kinetics costly construction materials limited much wider commercial use technology past ten years significant new developments mfcs resulted several fold increase achievable power density yet still considerable possibility improvement performance development new cost effective materials paper comprehensively reviews recent advances construction utilization novel anodes mfcs particular highlights critical roles functions anodes mfcs strategies available improving surface areas anodes dominant performance stainless steel based anode materials emerging benefits inclusion nanomaterials review also demonstrates materials promising large scale mfc applications likely replace conventional anodes development next generation mfc systems hurdles development commercial mfc technology also discussed furthermore future directions design selection materials construction utilization mfc anodes highlighted
microbial fuel cells mfcs treat organic compounds domestic wastewater without aeration additional procedure required remove nitrogen study developed flat panel air cathode mfc mfc comprised five mfc units connected series operated remove organic nitrogen compounds domestic wastewater short hydraulic retention time hrt eight months operation removal efficiencies chemical oxygen demand cod total nitrogen increased reaching respectively effluent cod concentrations respectively greatest removals cod first second unit removal rate mfc system allowed simultaneous removals cod domestic wastewater although led minimal power output first unit abiotic ammonia loss found supplied potential similar short hrt min biological nitrogen removal thought dominant mechanism removal mfcs microbial community analysis revealed near cathode nitrosomonas like strains contributed nitrification nitratireductor like strains led denitrification acidovorax like strains known metabolic diversity ubiquitous appeared contribute organics nitrogen removal anode cathode biofilms study provides proof concept mfc system promise energy sustainable wastewater treatment elsevier rights reserved
microbially influenced corrosion mic focusing increasing attention different research areas last years answer demand wide variety industries degradation cases difficulty reaching adequate understanding corrosion processes induced microorganisms result cross fertilization ideas researchers different disciplines like microbiology electrochemistry metallurgy materials engineering different mic mechanisms simultaneously alternately occuring various materials complex boundary layer corrosion products bacterial cells environmental factors present surface paper discusses new aspects mic mechanisms induced sulphate reducing bacteria species taking consideration modern techniques new approaches study practical cases concerning microbial risks failures illustrate complexity phenomena local corrosion problems stress corrosion cracking hydrogen damage role microstructure chemical composition materials also highlited key factor microbial damaging addition principal morphologies attack cracking described
microcontroller aided electro spin coating unit designed optimized fabricate nano fibers composite nano fibers zno fabricated using unit zno fibers annealed different temperatures degrees degrees using muffle furnace continuous fibers found defect free beads free structural composition fibers analyzed using xrd edax measurements ray diffraction peaks revealed fibers wurtzite hexagonal structure composition fiber confirmed zno percentage constituents zinc oxygen eadx results optical properties fibers studied using spectrophotometer optical band gap energy found surface morphology fiber studied using sem tem analysis fibers found defect free excellent material high sensitive optoelectronic sensors elsevier ltd rights reserved
microfluidics art creating manipulating small portions fluids typical variant art fluid transport within small channels either form laminar flow miscible streams form segmented flow dripping jetting immiscible streams either method provides means expose components interest defined local conditions spatially controlled concentration profiles could established without microfluidic auxiliaries ability renders microfluidics uniquely useful method advanced analytics synthesis article sheds spotlight use utility method macromolecular chemistry physics field synthetic aspect microfluidics widely explored macromolecular materials engineering primarily use droplets templates form various types polymeric particles capsules whereas analytical aspect prominently employed research biopolymers
microglia shift different complex morphologies depending microenvironment central nervous system cns distinct morphologies correlate specific functions indicate pathophysiological state cns previous postmortem studies autism spectrum disorder asd showed neuroinflammation asd indicated increased microglial density changes microglia density accompanied changes microglia phenotype individual contribution different microglia phenotypes pathophysiology asd remains unclear used unbiased stereological approach quantify six structurally functionally distinct microglia phenotypes postmortem human temporal cortex immuno stained ibal total density microglia phenotypes differ asd donors typically developing individual donors however significant decrease ramified microglia gray matter white matter asd significant increase primed microglia gray matter asd compared typically developing individuals increase primed microglia showed positive correlation donor age gray matter white asd typically developing individuals results provide evidence shift microglial phenotype may indicate impaired synaptic plasticity chronic vulnerability exaggerated immune responses elsevier inc rights reserved
microglia undergone extensive characterization shown present distinct phenotypes phenotypes depending stimuli highly specific neurotoxin hydroxydopamine ohda used understanding immune response parkinson disease dexmedetomidine dex centrally selective alpha adrenoceptor agonist performs well anti anxiety medication sedative analgesic present study investigated effects dex ohda induced microglial polarization results indicate treatment ohda promotes microglial polarization toward state microglia cells increasing release interleukin beta tumor necrosis factor alpha prevented pretreatment dex addition found ohda blocked mediated microglial polarization suppressing expression microglial markers arginase arg resistin like alpha retnla fizz chitinase like chil could ameliorated pretreatment dex notably inhibitory effects ohda mediated induction anti inflammatory marker genes transforming growth factor beta could significantly alleviated pretreatment dex dose dependent manner mechanistically alternations activation signal transducer activator transcription involved process findings suggest administration dex potential interrupt process microgliosis
microgravity experiments essential research space science biology fluid mechanics combustion material sciences one way conduct microgravity experiments earth using drop tower facilities facilities combine high quality microgravity adequate payload masses advantage virtually unlimited repeatability experimental conditions low cost collaboration institute space systems irs university stuttgart baylor university waco texas new drop tower currently development center astrophysics space physics engineering research casper design parameters drop tower ask least sin free fall duration providing quality least previously quality achieved vacuum drop tower facilities capsule experiences virtually zero aerodynamic drag free fall since design comes high costs different drop tower design concept require evacuated drop shaft chosen features dual capsule system experiment capsule shielded aerodynamic forces surrounding drag shield drop dual capsule drop tower able achieve quality good better previous work optimized design aerodynamic perspective using computational fluid dynamics cfd simulations determine ideal shape size outer capsule specify aerodynamically crucial dimensions overall system experiments later demonstrated required quality microgravity met proposed design main focus paper mechanical realization capsule well development layout surrounding components release mechanism deceleration device drop shaft drop tower facility complex system many interdependencies components several engineering challenges addressed example initial disturbances caused release mechanism common issue arises drop tower facilities vibrations may decrease quality microgravity initial segment free fall would reduce free fall time experiencing high quality microgravity mechanism developed provide soft release challenges proposed solutions components highlighted paper
micro gripper important tool manipulate assemble micro scale objects generally micro gripper small directly driven general motors always needs special driving devices suitable structure design paper two finger micro grippers designed fabricated utilize light induced deformation smart material make one two fingers smart material directly driven controlled remote lights instead lines motors light driven mode simplifies design two finger micro gripper avoids special drivers complex mechanical structure addition micro manipulation experiment system set based light driven micro gripper experimental results show remotely light driven micro gripper ability manipulate assemble micro scale objects air water furthermore two micro grippers also work together cooperation enhance assembly ability hand kind remotely controllable micro gripper require board energy storage used mobile micro robot manipulation hand
microorganisms everywhere recent studies showed mixture microbes microbiome human body plays important roles human physiology diseases metagenomic sequencing key technology studying microbiomes produces massive amounts data form short sequencing reads single metagenomic sample contain reads nucleotide length typical shotgun metagenomic sequencing study contain rich information microbiomes functions reading information huge highly fragmented data multiple challenges mathematical models bioinformatics methods computer algorithms paper review basic bioinformatics tasks existing methods processing analyzing metagenomic data discuss remaining open challenges practical observations aim paper provide readers whole picture metagenomic data processing analysis reference perspective start computational scientists interested exciting field
micropumps gained great potential applied biomedical devices micro systems low driven voltage flexible operation self sensing ability ionic polymer metal composite ipmc material used diaphragm micropumps paper presents novel design ipmc diaphragm helps produce larger deformation increase durability ipmc actuator unlike conventional design using single piece ipmc material clamped edges use several ipmc actuators clamped single edge drive elastic thin films eliminating edge constrains ipmc actuators new diaphragm provide significantly larger deformation moreover new design separates ipmc pumping fluid thus allows solvent cover ipmc maintain long operating duration incorporation physical induced stress model ipmc actuators visual ansys environment proposed analyze characteristic proposed diaphragms comparison conventional one experiments also carried demonstrate effectiveness proposed model experimental results show new diaphragm design produce deformation maintain stable operation min corresponding input signal conventional design produce deformation pumping performance decreases rapidly min elsevier rights reserved
microscopic colitis generic term includes main forms collagenous colitis lymphocytic colitis describes form inflammatory bowel disease chronic relapsing course incidence microscopic colitis times higher women men although age sex increases risk collagenous colitis odds ratio age women main symptom chronic non bloody watery diarrhoea common symptoms include abdominal pain result many patients microscopic colitis meet criteria irritable bowel syndrome colonoscopy multiple colonic biopsies currently recommended histological changes main characteristic feature colonic mucosa macroscopically normal although certain minimal endoscopic abnormalities described elsevier espana aeeh aeg rights reserved
microstructures scale tens microns change physical properties objects making lighter flexible traditionally difficult produce additive manufacturing lets physically realize microstructures low cost paper propose study procedural aperiodic microstructures inspired voronoi open cell foams absence regularity affords simple approach grade foam geometry thus mechanical properties within target object surface rather requiring global optimization process microstructures directly generated exhibit specified elastic behavior implicit evaluation akin procedural textures computer graphics locally adapts follow elasticity field allows detailed structures generated large objects without explicitly produce full representation mesh voxels complete object structures added fly object slice manufactured study elastic behavior microstructures provide complete description procedure generating explain determine geometric parameters microstructures target elasticity evaluate result printed samples finally apply approach fabrication objects spatially varying elasticity including implicit modeling frame following object surface seamlessly connecting microstructures
migraine brain disorder characterized piercing headache affects one side head located mainly temples area around eye migraine imparts substantial suffering family addition sufferer particularly affects three times women men prevalent ages years child rearing migraine typically occurs individuals genetic predisposition aggravated specific environmental triggers attempts study biochemistry migraine began early primarily directed serotonin metabolism increase hydroxyindoleacetic acid hiaa main metabolite serotonin observed urine migraineurs genetic biochemical studies primarily focused neurotransmitter serotonin considering receptor binding transport synthesis serotonin investigated serotonergic mediators including enzymes receptors well intermediary metabolites studies mainly assayed blood csf urine accessible fluids recently pet imaging technology integrated metabolomics systems biology platform applied study serotonergic biology general trend observed migraine patients alterations neurotransmitter metabolism detected biological fluids different biochemistry controls however interpretation biological significance peripheral changes unresolved review present biology serotonergic system metabolic routes serotonin discuss results biochemical studies regard alterations serotonin brain cerebrospinal fluid saliva platelets plasma urine migraine patients
migraine common primary headache disorder mechanisms underlying onset migraine attack completely understood environmental changes number factors could induce migraine attacks aim study investigate relationship frequency migraine attacks allergens migraine patients without aura healthy individuals similar age gender without history headache allergy prospectively included study duration migraine frequency migraine attacks medication history symptoms attacks questioned migraine disability assessment score midas visual analog scale vas scores obtained allergen extracts including dust fungi insect animal epithelium pollens food allergens applied allergy tests migraine patients healthy individuals enrolled study significant difference terms age gender median migraine disease duration number attacks month duration attacks respectively years day month mean midas grade mean vas score positivity allergy tests migraine group control group allergy tests positive house dust red birch hazel tree olive tree nettle wheat frequency migraine attacks higher allergy test positive patients negative ones migraine group migraine patients frequent attacks examined allergies
migraine common disabling headache disorder influenced multiple genes environmental triggers puberty prevalence migraine women three times higher men females suffering migraine report menstrual association suggesting hormonal fluctuations influence risk migraine attacks hypothesized drop estrogen menses important trigger menstrual migraine catechol methyltransferase comt cytochrome cyp enzymes involved estrogen synthesis metabolism functional polymorphisms genes influence estrogen levels therefore may associated risk menstrual migraine study investigated four single nucleotide polymorphisms three genes involved estrogen metabolism reported impact enzyme levels function specific menstrual migraine cohort menstrual migraine cases controls genotyped comt valmet cypa ileval cypa cysarg neither genotype allele frequencies comt cyp snps genotyped found significantly different menstrual migraineurs controls chi square analysis therefore find association functional polymorphisms estrogen metabolism genes comt cypa cypa menstrual migraine studies required assess whether menstrual migraine genetically distinct common migraine subtypes identify genes influence risk elsevier rights reserved
mild traumatic brain injury mtbi produce somatic symptoms headache dizziness fatigue sleep disturbances sensorimotor dysfunction sensorimotor function measured tests acoustic startle reflex asr evolutionarily conserved defensive response brief yet sharp acoustic stimulus mtbi produces long lasting suppression asr rodents humans however mechanism suppression unknown present study examined whether inflammatory processes brainstem particularly caudal pontine reticular nucleus pnc could account suppression asr mtbi pnc essential nucleus asr circuit furthermore inflammation mtbi commonly observed brain regions proximal site impact cortex hippocampus effects mtbi brainstem structures remains largely understudied present study demonstrated suppression asr one day injury lasting least three weeks mtbi replicating previous findings within pnc transient elevations beta tnf alpha mrna observed one day injury alpha mrna exhibited delayed increase three weeks injury reactive gliosis via iba microglia gfap astrocytes also observed pnc one day seven days injury respectively finally number giant neurons major functional cell population pnc decreased three weeks injury results indicate glial activation precedes neuronal loss pnc correlates behavioral suppression asr results also raise implications brainstem involvement development post traumatic symptoms elsevier inc rights reserved
mind body medicine system health practices includes meditation relaxation training guided imagery hypnosis biofeedback yoga art music therapy prayer tai chi psychological therapies cognitive behavioral therapy clinical hypnosis important mind body tool serves adjunct conventional medical care adolescent patient clinical hypnosis specifically uses self directed therapeutic suggestions cultivate imagination facilitate mind body connection leading positive emotional physical well many similarities clinical hypnosis mind body self regulatory modalities visual imagery mindfulness meditation yoga biofeedback incorporate experiential learning mechanisms change may viewed subtypes hypnotic experience share common experience trance entree self empowered change physiologic psychological states clinical hypnosis used health care providers teach adolescents coping skills deal wide variety conditions chronic headaches recurrent abdominal pain anxiety depression grief bereavement phobias anger family stressors sleep disorders enuresis clinical vignettes given help illustrate effectiveness hypnosis adolescents
mindful gnats computer game app introduces mindfulness relaxation skills young people aged nine years older paper authors describe model using technology support children development psychological skills model combines computer game introduce practice psychological skills played presence adult app assists young people practise transfer skills everyday life home school community mindful gnats computer game comprises six level game world available ios windows mindful gnats app available ios android operating systems paper describes background research informed design mindful gnats well specific mindfulness relaxation contents programme authors going research evaluate effectiveness mindful gnats regular children clinical difficulties described along key lessons authors learnt experience design mental health promoting technology
mines one labor intensive hazardous industries automation means industry significantly considered improve sustainability mine site health safety due complex nature larger scale underground mines recent years companies actively looking new automation methods particularly haul trucks effectively enhance productivity safety mine operations investigation lab scale cost effective automated haul truck designed developed enhance research development capacity area autonomous haul truck capable navigating path along underground tunnel environment using microcontroller microcontroller includes navigation algorithm based light detection ranging lidar sensor control algorithm based proportional integral differential pid controller multiple point path tracking approach simulation results also confirm effectiveness developed navigation control algorithms
minimally invasive surgery therapy mist popular used diagnosis surgery teleoperation new kind surgery used protect surgeon ray radiation however safety problem considered surgeon separated patient remotely effective address method design haptic interface master console provide immersive operation surgeon paper new haptic interface design catheter operation surgery controlling smart material magnetorheological fluids magnetic field haptic interface haptic performance calibration mechanism designed fabricated experiments done verify efficiency haptic interface used master console well training simulator non experience surgeon
minimization parasitic losses internal combustion engine essential improved fuel efficiency reduced emissions surface texturing emerged method palliating losses instances thin lubricant films lead mixed boundary regimes lubrication thin films prevalent contact compression ring cylinder liner piston motion reversals momentary cessation entraining motion paper provides combined solution reynolds equation boundary interactions gas flow model predict tribological conditions particularly piston reversals model validated measurements using floating liner determination situ friction engine motored condition good agreement obtained validated model used ascertain effect surface texturing liner surface reversals therefore paper combined study numerical predictions effect surface texturing predictions show marginal gains engine performance expected laser textured chevron features shallow depth certain operating conditions
mismatching clock feedthrough sources error switched current circuits producing offset gain errors harmonic distortion cause deviations filter responses passband stopband paper develops formulas including effects input output description filter building blocks make possible faster prediction filter performance levels also analyze tradeoffs early design stages block input output descriptions derived taking account real physical realization blocks together simple error models using behavioral input output descriptions studied extent effects performance two different filter realizations passive ladder structures one using integrators simulate signal flow graph sfg ladder another based use wave active filter waf structures monte carlo simulations filter example presented analyzed
missing fracture child skeletal surveys suspected non accidental trauma devastating results double read potential improve fracture detection however yield double read unknown determine advantage double read versus single read radiographic skeletal surveys suspected non accidental trauma study performed two phases first phase april september double read performed skeletal surveys obtained weekday working hours new double read findings studies initially read negative conducted second phase january march second phase limited double reads skeletal surveys found positive first read end period retrospectively performed double read initially negative skeletal surveys excluded follow skeletal surveys difference discrepancy new fracture false diagnosis fracture ratio negative positive skeletal surveys evaluated using fisher exact test change discrepancy ratio first second study phases evaluated using stratified cochran mantel haenszel test overall two phases skeletal surveys performed children girls mean age months range days years double read found discrepancies skeletal surveys seven studies showed additional fractures one study initial read skull fracture read variant second read significant difference rate disagreement negative skeletal surveys positive skeletal surveys significant change disagreement rate demonstrated two phases study double read skeletal survey suspected non accidental trauma found false negative fractures cases rarely found false positive diagnosis fracture double read uncommonly found discrepancies initially normal skeletal survey limiting double read initially positive studies improves yield double read
mixed signal integrated circuit design simulation highly rely behavioral models circuit blocks models used validation design specification optimization system topology behavioral synthesis using description language etc however automatic behavioral model generation still early stages scenarios designers responsible creating behavioral models manually time consuming error prone paper automatic behavioral model generation method switched capacitor integrator proposed technique based symbolic circuit modeling approximation parametric behavioral integrator model generated parametric models used circuit design subject severe process variational demonstrated automatically generated integrator models accurately capture process variation effects arbitrarily selected circuit elements furthermore applied behavioral simulation sigma delta modulators sdms acceptable accuracy speedup generated models compared recently proposed manually generated behavioral integrator model several simulation settings
mobbing type violence occurs workplaces classified community violence subgroup interpersonal violence aim study examine health care workers work primary health care city mugla determine whether relationship sociodemographic characteristics work conditions level mobbing cross sectional analysis conducted primary health care workers selected health workers participated yielding response rate health workers female midwives nurses doctors health workers faced mobbing last year frequency experiencing mobbing times per year total apply mobbing senior health workers female frequency encountering mobbing found significantly married health workers years according examined total working time psychosocial reactions counterproductive behaviors discovered primary health care workers high prevalence mobbing exposure avoid mobbing workplace authorities responsibilities employees clearly determined
mobile agent technology becoming popular implemented many distributed computing domains several research conducted address challenges including two important ones agent spawning agent mobility paper discusses issues mobile agent technology background mobile agent cloning spawning agent mobility well problems faced many researchers research mobile agents paper finally proposes new agent spawning mobility models resolve researchers problems
mobile cloud computing mcc combines features mobile computing cloud computing wireless networks create healthy computational resources mobile cloud users aim mcc execute highly attractive mobile applications plethora mobile cellular telephones highly rich user experience perspective mobile computing quality service qos provisioning depends efficiency handoff process thus highly important introduce energy efficient secure handoff process improve performance paper propose secure seamless fast handoff ssfh scheme improve energy efficiency qos mcc proposed scheme consists four layers application layer service layer infrastructure layer media layer four layers collectively handle security energy efficiency qos existing service oriented architectures designed mcc based symmetric encryption protocols support application layer however much easier adversary expose symmetric key gain access confidential data application layer secured using combination attribute based encryption asymmetric encryption cryptography extend mobile lifetime energy detection model deployed infrastructure layer detect energy level mobile devices prior pre registration process furthermore dual authentication process performed service application layer minimize possibility identity high jacked impersonation attack media layer supports secure handoff process using policy enforcement module allows legitimate users complete registration process initiating handoff thus significant amount bandwidth energy could preserved finally secure service oriented architecture programmed using platform results compared well known existing service oriented architectures experimental results confirm validity effectiveness proposed architecture elsevier ltd rights reserved
model based treatment planning exposimetry high intensity focused ultrasound requires numerical simulation nonlinear ultrasound propagation heterogeneous absorbing media computationally demanding problem due large distances travelled ultrasound waves relative wavelength highest frequency harmonic space pseudospectral method used solve set coupled partial differential equations equivalent generalised westervelt equation model implemented parallelised using message passing interface mpi solving large scale problems distributed clusters domain partitioned using slab decomposition global communication performed using sparse communication pattern operations spatial frequency domain performed transposed space reduce communication burden imposed fast fourier transform performance model evaluated using grid sizes grid points distributed cluster using compute cores given global nature gradient calculation model shows good strong scaling behaviour speed whenever number cores doubled means large scale simulations distributed across high numbers cores cluster minimise execution times relatively small overhead efficacy model demonstrated simulating ultrasound beam pattern high intensity focused ultrasound sonication kidney
modeling identification dynamic behavior ionic polymer metal composites widely used smart material inevitable work article unlike conventional methods modeled tip displacement uniform deformation ionic polymer metal composite modeled nonuniform deformation ionic polymer metal composite actuator final target method estimation prediction multi criteria dynamic mathematical model dynamic mathematical model defined way geometrical characteristics shape curvature consistent ionic polymer metal composite characteristics time model useful extract predict many geometrical even physical characteristics ionic polymer metal composite torque due ionic polymer metal composite weight curvature bending angle experimental results demonstrate proposed method capable identify predict ionic polymer metal composite nonuniform deformation curvature trajectory accurately even large deformation situation
models based deep convolutional networks dominated recent image interpretation tasks investigate whether models also recurrent effective tasks involving sequences visual otherwise describe class recurrent convolutional architectures end end trainable suitable large scale visual understanding tasks demonstrate value models activity recognition image captioning video description contrast previous models assume fixed visual representation perform simple temporal averaging sequential processing recurrent convolutional models doubly deep learn compositional representations space time learning long term dependencies possible nonlinearities incorporated network state updates differentiable recurrent models appealing directly map variable length inputs videos variable length outputs natural language text model complex temporal dynamics yet optimized backpropagation recurrent sequence models directly connected modern visual convolutional network models jointly trained learn temporal dynamics convolutional perceptual representations results show models distinct advantages state art models recognition generation separately defined optimized
models first impressions faces consistently found two underlying dimensions trustworthiness dominance dimensions show apparent parallels social psychological models inter group perception describe dimensions warmth trustworthiness competence dominance suggested reflect universal dimensions social cognition investigated whether dimensions face inter group social perception models indeed equivalent evaluating first impressions faces across four studies differing methods consistently found perceptions trustworthiness warmth closely related perceptions dominance competence less strongly related taken together results demonstrate strong similarity first dimension across facial social models less similarity second dimension suggest facial impressions competence dominance may represent different routes judging stranger capability help harm elsevier rights reserved
models reciprocity imply cheater detection important prerequisite successful social exchange considering fundamental role memory reciprocal exchange theories lead prediction memory cheaters preferentially enhanced examine whether information partner previous behaviour interaction automatically retrieved encountering face partner previously cheated cooperated two studies participants played sequential prisoner dilemma game cheaters cooperative partners alternating game blocks participants asked classify smiling angry facial expressions cooperators cheaters experiments revealed congruence effects reflecting faster identification smiles cooperators experiments faster identification angry facial expressions cheaters experiment study provides evidence automatic retrieval partner behaviour game regardless whether partners cheated cooperated thus provides evidence cheater detection hypothesis
moderate doses stimulant drugs known enhance memory encoding consolidation effects memory retrieval explored depth laboratory animals stimulants seem improve retrieval emotional memories comparable studies carried humans present study examined effects dextroamphetamine amp retrieval emotional unemotional stimuli healthy young adults using doses enhanced memory formation administered encoding previous study sessions healthy volunteers received doses amp placebo counterbalanced order double blind conditions session first viewed emotional unemotional pictures words drug free state days later memory tested hour amp placebo administration dextroamphetamine affect number emotional unemotional stimuli remembered doses increased recall intrusions false recognition dextroamphetamine also increased number positively rated picture descriptions words generated free recall data provide first evidence therapeutic range doses stimulant drugs increase memory retrieval errors ability amp positively bias recollection prior events could contribute potential abuse
moderate urinary dysfunctions including frequent urination reactive bladder age related deteriorating urinary condition saw palmetto extract pumpkin seed oil used prevention course evaluation activities urinary dysfunctions edible fruits found extract seaberry sbe suppressed bladder constriction carbacol induced constriction rat bladder specimen sbe significantly suppressed constriction sbe also suppressed tgf beta induced constriction collagen gel containing bladder muscle cells among constituents sbe ursolic acid isorhamnetin rhamunoside significantly suppressed carbacol induced bladder constriction hand coumaroyl dihydroxy oleanolic acid ursolic acid uvaol pomolic acid oleanolic aldehyde isorhamnetin rhamnoside significantly suppressed tgf beta induced collagen gel constriction containing bladder muscle cells results suggest several triterpenoids flavonoid glycoside suppressed bladder constriction sbe may contribute suppression urinary dysfunctions caused overactive bladder elsevier ltd rights reserved
modern cars equipped active passive sensor systems detect potential collisions contrast locusts avoid collisions solely responding certain visual cues associated object looming neurophysiological experiments investigated possibility collision detector neurons locusts respond impending collisions films recorded dashboard cameras fast driving cars complementary modelling approach developed simple algorithm reproduce neuronal response recorded object approach instead applying elaborate algorithms factored object recognition optic flow discrimination tested hypothesis motion detection restricted danger zone frontal collisions motorways likely sufficient estimate risk collision furthermore investigated whether local motion vectors obtained differential excitation simulated direction selective networks could used predict evasive steering maneuvers prevent undesired responses motion artifacts results study demonstrate risk impending collisions real traffic scenes mirrored excitation collision detecting neuron dcmd locusts modelling approach able reproduce neuronal response even vehicle driving high speeds image resolution low pixels furthermore evasive maneuvers involved changing steering direction steering force could planned comparing differences overall excitation levels simulated right left direction selective networks additionally possible suppress undesired responses algorithm translatory movements camera shake ground shadows evaluating local motion vectors estimated collision risk values evasive steering vectors could used input driving assistant converting first braking force latter steering responses avoid collisions since many processing steps computed level pixels involved elements directionselective networks algorithm implemented hardware parallel computations enhance processing speed significantly
modern cryptographic protocols require good entropy sources unfortunately many networked devices lack subsystems dedicated task potentially susceptible random number generator rng attacks yet systems allow software upgrades host communication ports providing option retrofit work illustrates chaotic dynamics used design sub entropy source capable kbit rate offering multiple serial communication abilities operation based standard microcontroller exploits loop built around one analog digital converters adcs design offers self testing features enables experimental validation recent results choice best state quantization function employ using chaotic maps rngs
modern distributed water aware technologies including example greywater recycling rainwater harvesting enable water reuse scale household neighbourhood nevertheless even though technologies cases economically advantageous significant handicap compared centralized urban water management options easy estimate priori extent rate technology spread disadvantage amplified case additional uncertainty due expansion urban area overall incertitude one basic reasons stakeholders involved urban water sceptical distributed technologies even cases appear lower cost study suggest methodology attempts cope uncertainty coupling cellular automata system dynamics model model used create scenarios urban expansion including suitability installing water aware technologies new urban area model used estimate adoption rate technologies various scenarios based different economic conditions water prices assessed suggested methodology applied urban area attica greece
modern gpgpu enabled massively parallel computing programmability exploit highly parallel nature ldpc decoding previous works customized design gpgpu towards specific execution attributes particular ldpc decoding matrix supporting different ldpc decoding matrices requires either substantial rework current program brand new parallel design paper proposes two unified designs achieve high performance regular irregular ldpc decoding gpgpu first design introduces node based scheme versatile translation array mechanism efficiently handle complex data access patterns different ldpc decoding matrices second design proposes edge based parallel paradigm uses intuitive data layout edges nodes tanner graph also give edge based design higher computation parallelism limited concurrent codewords proposed unified designs designers ignorant types ldpc matrices achieve high performance ldpc decoding experiments gtx gpgpu demonstrated runtime improvement compared designs high end cpu maximum throughput reach mbps compared previous customized designs proposed systematic designs reach better performance relieving effort customization
modern gpus feature complex memory system designs one gpu may contain many types memory different properties best way place data memory sensitive many factors program inputs architectures making portable optimizations gpu data placement difficult challenge porple recently proposed method overcomes difficulties enabling online optimizations data placement three way synergy specification language memory system description compiler framework data access analysis code staging runtime library efficiently finding materializing data placement fly article provides comprehensive description method presents several extensions significantly improve scalability porple include novel algorithm design efficiently searching best data placements use active profiling reducing online profiling overhead systematic examination path based performance model automatically tailoring data placements execution gpu program enhanced porple brings significant speedups average many gpu kernels across gpu architectures program inputs
modern parallel computing devices graphics processing unit gpu gained significant traction scientific statistical computing particularly well suited data parallel algorithms particle filter generally sequential monte carlo smc increasingly used statistical inference smc methods carry set weighted particles repeated propagation weighting resampling steps propagation weighting steps straightforward parallelize require independent operations particle resampling step difficult standard schemes require collective operation sum across particle weights focusing resampling step analyze two alternative schemes involve collective operation metropolis rejection resamplers compare standard schemes multinomial stratified systematic resamplers find certain circumstances alternative resamplers perform significantly faster gpu lesser extent cpu standard approaches moreover single precision standard approaches numerically biased upward hundreds thousands particles alternatives particularly important given greater single double precision throughput modern devices consequent temptation use single precision greater number particles finally provide auxiliary functions useful implementation permutation ancestry vectors enable place propagation supplementary materials available online
modified natural cycle ivf lower pregnancy rate per started cycle compared ivf ovarian stimulation due example premature ovulation indometacin administered ovulation prevents follicle rupture therefore addition indometacin may improve effectiveness modified natural cycle ivf double blind randomized placebo controlled trial indometacin placebo women aged years compared number patients without premature ovulation compared number patients one ovulations maximum six cycles indometacin significant influence probability premature ovulation patients six cycles subgroup analysis showed significant influence indometacin decreasing probability premature ovulation cycles without surge day human chorionic gonadotrophin administration although study could detect significantly lower ovulation rate indometacin group versus placebo group data suggest subgroup patients without surge prior oocyte retrieval might benefit indometacin modified natural cycle ivf reproductive healthcare ltd published elsevier ltd rights reserved
molecular model petroleum fractions plays important role designing simulation optimization petrochemical processes pyrolysis process catalytic reforming fluid catalytic cracking fcc however difficult exactly characterize composition distributions due internal complexity containing numerous redundant information measuring errors although many efforts made far improvement work mei molecular based representation method within multi dimensional state space developed paper method pure component petroleum mixtures defined state variable petroleum fractions geometrically represented point multi dimensional linear state space conception basis fractions introduced defining group linear independent vectors petroleum fractions within specified range naphtha obtained linear combination basis fractions redundant information measuring errors predetermined petroleum fraction samples eliminated procedure calculating basis fractions non negative matrix factorization nmf algorithm meanwhile scale feedstock database highly decreased application example basis fractions quick prediction approach naphtha pyrolysis product distributions developed linearly combining pyrolysis products basis fractions contrast mechanistic models proposed method suitable real time control optimization purpose little loss accuracy elsevier ltd rights reserved
monoamine oxidase types mao mao regulate levels monoamine neurotransmitters brain dysfunction may involved pathogenesis influence clinical phenotypes neuropsychiatric disorders reversible mao inhibitors moclobemide befloxatone currently employed treatment emotional disorders inhibiting enzymatic degradation dopamine serotonin norepinephrine central nervous system cns suggested irreversible mao inhibitors selegiline rasagiline exert neuroprotective effect parkinson alzheimer diseases effect however related inhibition mao activity animal cellular models selegiline rasagiline protect neuronal cells anti apoptotic activity induction pro survival genes increasing evidence mao activity mao implicated pathophysiology neurodegenerative disorders also gene induction mao inhibitors hand selegiline rasagiline increase mao mrna protein enzyme activity levels taken together results suggest mao subtype exerts effects modulate expression activity isoenzyme roles mao cns therefore evaluated respect type specificity inhibitors may unconditional chronic treatment mao expression particular may implicated pathogenesis phenotypes neuropsychiatric disorders mao expression modified mao polymorphisms affecting transcriptional efficiency well mutations polymorphism parkin sirt foxo microrna presenilin regulatory proteins addition childhood maltreatment shown impact upon adolescent social behavior children mao polymorphisms low transcriptional activity low mao activity may increase levels serotonin norepinephrine resulting disturbed neurotransmitter system development behavior review discusses genetic environmental factors involved regulation mao expression contexts neuropsychiatric function regulation neuronal survival death
monomorphic plasmacytoma type posttransplant lymphoproliferative disorder ptld reported pediatric hematopoietic stem cell transplantation present child hepatitis associated severe aplastic anemia underwent unrelated allogeneic hematopoietic stem cell transplantation subsequently developed graft failure epstein barr virus positive monomorphic plasmacytoma type ptld recipient origin despite broad spectrum antimicrobials weaning immunosuppression rituximab administration stem cell boost died complications ptld fungal pulmonary infection day
morality sociability competence distinct dimensions person perception argue person morality informs likely intentions whereas competence sociability inform likelihood fulfill intentions accordingly hypothesized whereas morality would considered unconditionally positive sociability competence would highly positive moral others would less positive immoral others using exploratory factor analyses studies distinguished evaluations morality sociability studies showed sociability competence evaluated positively contingent moralitystudy demonstrated phenomenon remaining studies explained study generalized studies ruled alternative explanation study study showed positivity morality traits independent morality traits results support functionalist account dimensions person perception
morbidity mortality bcr abl negative myeloproliferative neoplasm mpn patients influenced disease related hemostatic complications mostly thrombotic nature pathogenesis thrombosis multifactorial particular demonstrated deregulated expression mac also known surface receptor integrin cdb leukocytes role favoring platelets activation mpn patients based data investigated epigenetic status cdb primary myelofibrosis pmf patients explore possible association epigenetic profiles two genes thrombotic risk percentage methylation pmf samples ranged hypomethylated hypermethylated range mean whereas controls methylation status clustered restricted interval range mean cases controls furthermore results showed hypermethylation methylation correlated thrombotic complications contrary cdb promoter resulted unmethylated cases controls previous studies showed older age jakvf mutation thrombophilia might play role mpn patients thrombotic risk cases prognostic value variables coherent thrombotic events significantly associated age years jak mutation positive thrombophilia tests however multivariate analysis showed methylation age years independent prognostic factors thrombosis respectively taken together findings suggest possible role epigenetic regulation pathogenesis thrombotic complications pmf patients
morphological operators widely used binary image processing several purposes removing noise detecting contours particular structures regularizing shapes particular morphological filters largely adopted scanned documents correct artifacts caused acquisition binarization well processing paper propose novel approach forensics detection morphological filtering binary images proposed technique exploits mathematical properties two basic morphologic operators erosion dilation define algorithm able detect application filter also estimate shape relevant structuring element experimental tests demonstrate technique effective robust common operations performed binary image documents
children experience acquired demyelinating syndrome central nervous system monophasic disease course clinical radiological symptoms subset diagnosed multiple sclerosis life long disorder using linear mixed effects models examined longitudinal diffusion properties normal appearing white matter serial scans paediatric participants acquired demyelinating syndromes followed median years many first clinical presentation scans healthy paediatric participants fifty three participants demyelinating syndromes eventually received diagnosis paediatric onset multiple sclerosis diffusion tensor imaging measures properties water diffusion tissue normally becomes increasingly restricted anisotropic brain childhood adolescence fibre bundles develop myelinate healthy paediatric participants data demonstrate expected trajectory restricted anisotropic white matter diffusivity increasing age however participants multiple sclerosis fractional anisotropy decreased mean diffusivity non lesional normal appearing white matter progressively increased clinical presentation suggesting failure age expected white matter development also progressive loss tissue integrity surprisingly patients monophasic disease failed show age expected changes diffusion parameters normal appearing white matter although show progressive loss integrity time analysis demonstrated participants monophasic disease experienced different post onset trajectories normal appearing white matter depending presenting phenotype acute disseminated encephalomyelitis demonstrated abnormal trajectories diffusion parameters compared healthy paediatric participants patients non acute disseminated encephalomyelitis presentations associated lesions brain onset patients monofocal syndromes optic neuritis transverse myelitis isolated brainstem syndromes multifocal brain lesions absent showed trajectories closely approximating normal appearing white matter development findings also suggest existence sexual dimorphism effects demyelinating syndromes normal appearing white matter development overall demonstrate failure white matter maturational changes progressive loss white matter integrity paediatric onset multiple sclerosis also show even single demyelinating attack associated white matter lesions brain negatively impacts subsequent normal appearing white matter development
concurrent data structures designed today versions known sequential data structures however various cases makes sense relax semantics traditional concurrent data structures order get simpler possibly efficient scalable implementations example solving classical producer consumer problem implementing concurrent queue might enough allow dequeue operation consumer return remove one two oldest values queue necessarily oldest one define infinitely many possible relaxations several traditional data structures objects queues stacks multisets registers examine relative computational power
distributed computing applications require effective scheduling algorithm distribute assign client tasks running set processors existing algorithms assumed scheduled tasks simultaneously ideally sent received processors without latent delay however assumption obviously impractical unrealizable due lack consideration constraints caused limited number existing ports client site port constraint confines overall throughputs computing systems study investigates theoretical scheduling patterns constraint one port typically exists achieve optimal makespan latent delay heuristic algorithm effectively schedule given set tasks also proposed two primary scheduling patterns leading optimal makespan delay discovered performance proposed scheduling better scheduling algorithms imposed constraints terms shorter makespan less latent delay particular average time complexity equal elsevier rights reserved
intranasal oxytocin research date carried men recent studies indicate females responses differ substantially males randomized double blind placebo controlled study involved female sample women using hormonal contraception participants viewed animations geometric shapes depicting either random movement social interactions playing chasing fighting probe questions asked whether shapes friends friends social videos preceded cues attend either social relationships physical size changes subjects received intranasal placebo spray scan experimenter blinded nasal spray contents scan participants scan followed randomized double blind design scan half received second placebo dose half received iii intranasal oxytocin measured neural responses animations baseline well change neural activity induced oxytocin oxytocin reduced activation early visual cortex dorsal stream motion processing regions social size contrast indicating reduced activity related social attention oxytocin also reduced endorsements shapes friends friends significantly correlated reduction neural activation furthermore participants perceived fewer social relationships baseline likely show oxytocin induced increases broad network regions involved social perception social cognition suggesting lower social processing baseline may predict positive neural responses oxytocin
ocean acidification experimental systems rely indirect way control however accurate measurements difficult obtain shifts temperature salinity alter relationship pco describe system target pco controlled via direct analysis pco seawater direct type control accommodates potential temperature salinity shifts target variable directly measured instead estimated water header tank permanently circulated air water equilibrator equilibrated air routed infrared gas analyzer irga measures pco conveys value proportional integral derivative pid controller controller commands solenoid valve opens closes flush bubbled header tank low cost control system allows maintenance stabilized levels pco extended periods time ensuring accurate experimental conditions system used study long term effect coralline red algae phymatolithon lusitanicum found months high exposure photosynthesis increased opposed respiration positively affected temperature results showed system adequate run long term experiments easily adapted test relevant variables simultaneously temperature irradiance nutrients
research effort area software analysis focused perspective developer software developing company ways software development process could improved however type software assessment common industry also assessments commissioned parties primary recipients software solutions courts dealing legal cases related software products services work presents one case study performed public administration italy paper describes assessment also points need focused research providing comparison developer oriented customer oriented assessment types elsevier inc rights reserved
well known supervised dimensionality reduction methods assume unimodal gaussian like lihoods may appropriate real life applications manuscript introduce novel supervised dimensionality reduction approach moments discriminant analysis models linear relationships high dimensional input space low dimensional space maximizing discrimination second order raw moments different classes improve generalization capability classifier unlike state art methods moments discriminant analysis intended accommodate data distributions may multimodal non gaussian initially experiments using synthetic random data generated different probability distributions performed prove efficiency proposed method multimodal non gaussian data help five separability measures also extensive experimental results uci machine learning repository image retrieval wang mit oliva torralba databases carried order exhibit effectiveness moments discriminant analysis state art methods
victims child abuse experienced one type maltreatment yet lack understanding impact specific combinations types maltreatment study aimed identify meaningful classes maltreatment profiles associate short term clinical outcomes total german children adolescents aged known history child maltreatment included study interviews questionnaires information obtained participants primary caregivers history maltreatment sociodemographics psychopathology level psychosocial functioning health related quality life types abuse categorized six major groups sexual abuse general sexual abuse penetration physical abuse emotional abuse neglect exposure domestic violence latent class analysis lca performed determine distinct multi type maltreatment profiles assessed associations sociodemographic clinical outcome variables lca revealed participants could categorized three meaningful classes according history maltreatment experience multiple types maltreatment excluding sexual abuse experience multiple types maltreatment including sexual abuse experience predominantly sexual abuse members class showed significantly worse short term outcomes psychopathology level functioning quality life compared classes three distinct profiles multiple types maltreatment empirically identified sample exposure multiple types abuse associated poorer outcomes elsevier ltd rights reserved
mother son incest well female pedophilic disorder remain underrecognized misdiagnosed case female child abuser suffered hypersexual disorder mental retardation whose son viewed substitute transitional sexual partner clinical case shared common features female sex offenders previously described literature association sexual gratification hypersexuality without pedophilic fantasies quite uncommon female child abusers
motor proteins molecules convert chemical energy mechanical work responsible motility across levels transport within cell motion individual cell surroundings movement multicellular aggregates muscles bacterial flagellar motor one canonical examples molecular complex made several motor proteins self assembles demand provides locomotive force bacteria locomotion provides key aspect bacteria prevalence outline biophysics behind assembly energetics switching rotation remarkable nanoscale electric motor nature first wheel
motor symptoms define parkinson disease caused selective loss nigral dopaminergic neurons cell replacement therapy focused midbrain neurons derived human fetal mesencephalic tissue human embryonic stem cells hesc human induced pluripotent stem cells ipsc recent development direct conversion human fibroblasts induced dopaminergic ida neurons offers new opportunities transplantation study disease modeling ida neurons generated directly human fibroblasts short period time bypassing lengthy differentiation process human pluripotent stem cells concern potentially tumorigenic mitotic cells exhibit functional dopaminergic neurotransmission relieve locomotor symptoms animal models parkinson disease review discuss recent development implications parkinson disease research therapy
mounting awareness climate change recent years led construction industry initiate new approaches toward sustainable building design yet stakeholders hospitality development still hesitate build green reluctance due perceived high guest expectations comfort levels amenity access among properties research conducted determine precisely green building innovations present significant barriers incorporating sustainability design hospitality average leed credit implementation rates among existing leed hotel projects calculated compared average credits employed among common commercial building projects projects designers also offered survey opinions sustainable innovations commonly avoided approaches hospitality results indicate certain credits experience decreased popularity among hospitality projects yet guest comfort barrier identified cost implementation local applicability affected climate local bylaws also found major role players selection credits specific hospitality design conclusions presented according data recommendations made support growth success future applications leed sustainable design hospitality authors production hosting elsevier open access article license http creativecommons org licenses
type lead hexaferrites compositions pbfeo pbsnznfeo synthesized citrate sol gel method structural magnetic properties resultant particles investigated ray diffraction xrd transmission electron microscope tem vibrating sample magnetometer vsm vector network analyzer magnetic properties saturation magnetization coercivity calculated hysteresis loops microwave absorption properties ferrite polymer composites prepared different ferrite ratios investigated frequency range ghz composite powder lead ferrite possesses good microwave absorption properties minimum reflection loss composite powder reaches thickness composite powder ferrite composite ferrite content shown minimum reflection loss ghz bandwidth extended frequency range ghz absorber thickness prepared composites fruitfully utilized suppression electromagnetic interference emi reduction radar signatures stealth technology
much written promise peril technology education paper presents empirical study explores technology play pivotal role student learning teaching staff adopt innovative technology based approaches creation interactive online problem based learning pbl resources allowing students interact authentic complex realistic problems designed within framework pbl methodology application pbl approaches within authentic situated learning contexts shown literature deepen student learning outcomes paper demonstrates innovative authoring tools promote problem solving skills acquisition domain specific knowledge introduced part university wide elearning strategic blueprint overall student feedback positive many students commenting realism even enjoyment online problem simulations however major challenges met implementation requiring several support activities across organisation
much known serious neurological effects gluten ingestion coeliac disease patients sporadic ataxia peripheral neuropathy although causal links gluten still debate however disorders observed small percentage coeliac patients much less known transient cognitive impairments memory attention executive function speed cognitive processing reported majority patients coeliac disease mild degradations cognitive functions referred brain fog yet formally recognized medical psychological condition however subtle tests cognitive function measurable untreated patients coeliac disease improve first months therapy gluten free diet deficits also occur patients crohn disease particularly association systemic inflammatory activity thus cognitive impairments associated brain fog psychologically neurologically real improve adherence gluten free diet yet sufficient evidence provide definitive account mechanism gluten ingestion causes impairments cognitive function associated brain fog current evidence suggests likely causal factor directly related exposure gluten
much fabric today society odds planning robust generative public health response child maltreatment prevention critical component problem absence public policy framework related infrastructure create common ownership problem recognizing vast differences individual willingness capacity alter parenting behaviors address challenge seems prudent begin building universal system assessment support touch children families multiple points developmental process system would simply identify highest risk rather system would built premise parents issues concerns differ extent capacity address issues commentary outlines key elements system benefits strengthening impacts interventions collective support children
much recent research executive characteristics focuses attributes society tends view negatively self interest self serving bias narcissism providing insights executives impact organizational outcomes may attributes positively viewed society present top management teams tmts overlooked specifically tmt modesty though modesty deviates conventional view executives evidence social psychology suggests modesty positively impacts career success upward mobility suggesting least individuals rise level tmt modest previously expected building insight argue tmt modesty elicits positive investor reactions following earnings calls corresponds higher levels firm performance
much research established negative association gender nonconformity psychological health less known however regarding factors may attenuate link gender nonconformity psychological health present study aimed investigate association gender nonconformity psychological health singaporean sample examine trait mindfulness self compassion potential moderators association community sample adults recruited completed online survey anonymously survey included measures gender nonconformity sexual orientation trait mindfulness self compassion depression anxiety subjective well results showed gender nonconformity positively significantly predicted depressive symptoms negatively predicted subjective well trait mindfulness moderated association gender nonconformity depression anxiety subjective well respectively direction moderation effects indicating role trait mindfulness protective factor psychological distress self compassion moderated relationship gender nonconformity subjective well specifically association gender nonconformity subjective well positive high levels self compassion negative low levels self compassion cross sectional nature findings provide preliminary support role trait mindfulness self compassion potential buffers negative psychological effects gender nonconformity
mucormycosis aspergillosis two opportunistic fungal infections evolve life threatening complications generally affect patients relevant risk factors immunocompromisation long term use antibiotics corticosteroids treatment usually combines medical surgical approaches often including extended necrosectomies although prognosis generalized fungal infections poor paper present case year old girl affected combined aspergillosis mucormycosis following treatment recurrent glioma patient hospitalized suspected cellulitis right hemi face involving frontal maxillary area upper airways immediately put intravenous antibiotic therapies performing nasal septum maxillary biopsies concomitant mucormycosis aspergillosis diagnosed antimycotic therapy liposomal amphotericin administered evaluation oral surgeon otolaryngologist surgical cranio facial necrosectomy suggested refused parents patient girl died days later due respiratory arrest awareness pathology prompt diagnosis early treatment may improve outcome infections reduce mortality
mucormycosis commonly affects immunocompromised individuals defects neutrophil function count diabetes mellitus important risk factor due impair innate acquired immunity mucormycosis rhino orbital cerebral involvement common presentation pulmonary mucormycosis although rare presentation diabetic patients associated high mortality morbidity early diagnosis difficult due rarity disease clinical radiological features resembling tuberculosis common pakistan present three cases chronic patients diabetes apparent risk factors
mucosal melanomas rare subtype melanoma arising mucosal tissues poor prognosis due lack effective targeted therapies study aimed better understand molecular landscape cancers find potential new therapeutic targets whole exome sequencing performed mucosal melanomas patients sun exposed cutaneous melanomas matched peripheral blood samples available mutational profiles compared mucosal subgroups sun exposed cutaneous melanomas comparisons molecular profiles identified genes enriched mucosal melanoma kit frequently comutated mucosal subgroup significantly higher incidence cutaneous melanoma recurrent sfb mutations identified validated mucosal melanoma patients mutations spliceosome pathway found enriched mucosal melanomas compared cutaneous melanomas alternative splicing four genes observed sfb mutant samples compared wild type samples study identified potential new therapeutic targets mucosal melanoma including comutation kit recurrent mutations sfb first report sfb mutations vulvovaginal mucosal melanoma largest whole exome sequencing project mucosal melanomas date results also indicated mutations sfb lead alternative splicing multiple genes findings expand knowledge rare disease copyright author published wolters kluwer health inc
multi context systems mcss introduced brewka eiter promising way interlink decentralized heterogeneous knowledge contexts paper propose preferential multi context systems pmcss provide framework incorporating preference contexts mcss pmcs contexts divided different strata according preference information flows context contexts stratum less preferred strata given positive integer first preferred strata pmcs able fully capture information exchange contexts strata thus contexts form new pmcs called section original pmcs generalize equilibrium semantics mcs equilibria pmcs equilibrium represents belief state acceptable least section given pmcs also investigate inconsistency analysis pmcs related computational complexity issues elsevier inc rights reserved
multicore architectures becoming promising computing platforms thanks high performance soft error rate multicore systems increases trend transistor sizes reduction voltage transistors evaluating impact soft errors parallel applications critical understand fault characteristics decide fault tolerance strategies reliable execution paper examine soft error vulnerabilities shared data parallel java applications analyze fault behavior shared data parallel programs design implement bytecode instrumentation based analysis fault injection framework evaluate fault behavior shared data fields set parallel applications nas benchmark suite experimental evaluation demonstrates data type access characteristics shared fields shows shared data structures parallel applications vulnerable soft errors error rates unshared local data stay around target applications rate shared data exceeds applications discuss potential directions results shared data analysis employed apply partial fault tolerance techniques elsevier rights reserved
multicore processors become integral part modern large scale high performance parallel distributed computing systems unfortunately applications located multicore processors suffer decreased performance increased dynamic energy use result interference shared resources memory interference difficult characterize assumptions application execution time energy usage misleading presence location consequently important accurately characterize performance energy usage applications execute located manner architectures work investigates disadvantages location presents methodology building models capable utilizing varying amounts information target application located applications make predictions target application execution time system energy use arbitrary locations wide range application types proposed methodology validated three different server class intel xeon multicore processors using eleven applications two scientific benchmark suites model utility scheduling also demonstrated simulated large scale high performance computing environment creation location aware scheduling heuristic heuristic demonstrates scheduling using information generated proposed modeling methodology capable making significant improvements scheduling heuristic oblivious location interference
multifunction systems operate different functions like radar communication electronic warfare offer variety benefits beyond well known aesa active electronically steerable antenna features reach sufficient technology maturity start product development series challenges stemming large required operation bandwidth resolved dual polarised low loss apertures array grids designed grating lobe scan blindness free conical field view fov highest operational frequency considered active components aesa especially required power efficient whole multifunction bandwidth shall miniaturised fit array grid functions like high speed datalink require linear high power amplification low harmonics generation interference suppression receive essential order maintain performance enablers broadband aesa gan technology front end components sice bicmos technology core chip digital control paper shows state art technology europe multifunction systems
multigranulation rough set constructed family equivalence relations attracted much attention offers theoretical framework problem solving view multigranulation however granular structure information systems often dynamically evolves time dynamically obtain potential useful knowledge decision making great significance context multigranulation motivated requirement paper present definitions equivalence relation matrix diagonal matrix cut matrix single granular structure multigranulation rough set propose matrix representation multigranulation approximations optimistic pessimistic multigranulation rough set corresponding matrix based dynamic approaches updating approximations proposed multigranulation rough set single granular structure evolves time experimental evaluations show effectiveness proposed matrix based dynamic updating algorithms compared matrix based static algorithm elsevier rights reserved
multi label image classification challenging problem computer vision motivated recent development image classification performance using deep neural networks work propose flexible deep convolutional neural network cnn framework called local global cnn lgc improve multi label image classification performance lgc consists firstly local level multi label classifier takes object segment hypotheses inputs local cnn output results local hypotheses aggregated together max pooling weighted consider label occurrence inter dependencies information using graphical model label space lgc also utilizes global cnn trained multi label images directly predict multiple labels input predictions local global level classifiers finally fused together obtain map estimation final multi label prediction lgc framework could benefit pre train process large scale single label image dataset imagenet experimental results shown proposed framework could achieve promising performance pascal voc voc multi label image dataset
multilevel inverters mli suitable renewable energy sources operate lower switching frequency voltage sinusoidal pwm spwm techniques popularly employed mlis improve drive performance however number switches increase leads switching losses higher price size inverter study modified reduced switch mli rsmli five switches proposed various multilevel inverter topologies different multicarrier spwm techniques phase disposition phase opposition disposition alternative phase opposition disposition apod derived analysed presented proposed rsmli inverter topologies simulated scheme lowest thd identified hardware setup built proposed rsmli using digital signal processor dsp pulse generation results validated vector control scheme industrial standard requires accurate fast estimator stable performance neural based estimator proposed authors implemented fpga proposed rsmli fed induction motor drive examined without neural based estimator encouraging results obtained using proposed rsmli reported
multi loop feedback control attracted considerable attention due simplicity ease implementation order simplify cumbersome analysis multiloop circuit signal flow graph representation used rather familiar nodal analysis methods paper presents criterion well established mason formula multi loop oscillator terms signal flow graphs multi loop oscillator circuit based two operational transresistance amplifiers otras used example
multimedia contents inherently sensitive signals must protected whenever outsourced untrusted environment problem becomes challenge untrusted environment must perform processing sensitive signals paradigmatic example cloud based signal processing services approaches based secure signal processing ssp address challenge proposing novel mechanisms signal processing encrypted domain interactive secure protocols achieve goal protecting signals without disclosing sensitive information convey paper presents novel comprehensive set approaches primitives efficiently process signals encrypted form using number theoretic transforms ntts innovative ways usage ntts paired appropriate signal pre post coding enables whole range easily composable signal processing operations comprising among others filtering generalized convolutions matrix based processing error correcting codes main focus unattended processing interaction client needed implementation purposes efficient lattice based somewhat homomorphic cryptosystems used exemplify approaches evaluate performance accuracy proving proposed framework opens wide variety new applications secured outsourced processing multimedia contents
multimodal damping achieved coupling mechanical structure electrical network exhibiting similar modal properties focusing plate new topology electrical analogue found finite difference approximation kirchhoff love theory use direct electromechanical analogy discrete models based element dynamic stiffness matrices proposed simulate square plate unit cells coupled electrical analogues two dimensional piezoelectric transducers setup made clamped plate covered array piezoelectric patches built order validate control strategy numerical models analogous electrical network implemented passive components inductors transformers inherent capacitance piezoelectric patches effect piezoelectric coupling dynamics clamped plate significant creates equivalent multimodal tuned mass damping adequate tuning network yields broadband vibration reduction end use analogous electrical network appears efficient solution multimodal control plate
multimodal passive damping mechanical structure implemented coupling secondary structure exhibiting similar modal properties considering piezoelectric coupling secondary structure electrical network suitable topology network obtained finite difference formulation mechanical equations followed direct electromechanical analogy procedure applied kirchhoff love theory order find electrical analogue clamped plate passive electrical network implemented inductors transformers inherent capacitance piezoelectric patches electrical resonances tuned approach several mechanical modes simultaneously yields broadband reduction plate vibrations array interconnected piezoelectric patches robustness control strategy evaluated introducing perturbations mechanical electrical designs non optimal tuning considered way uniform variation network inductance effect local boundary modi fications electromechanical system observed experimentally end use analogous electrical network appears efficient robust solution multimodal control plate
multi mode resource precedence constrained project scheduling well known challenging real world optimisation problem important variant problem requires scheduling activities multiple projects considering availability local global resources respecting range constraints critical aspect benchmarks addressed paper primary objective minimise sum project completion times usual makespan minimisation secondary objective observe leads expected different overall structure good solutions discuss effects algorithm design paper presents carefully designed hybrid monte carlo tree search novel neighbourhood moves memetic algorithms hyper heuristic methods implementation also engineered increase speed iterations performed exploit computing power multicore machines empirical evaluation shows resulting information sharing multi component algorithm significantly outperforms solvers set hidden instances instances available algorithm design phase elsevier inc rights reserved
multi objective optimisation design procedures shown valuable tool control engineers enable designer close embedment tuning process wide variety applications procedures evolutionary multi objective optimisation extensively used pid controller tuning one reason due flexibility include mechanisms order enhance convergence diversity although usability dealing multi variable processes resulting pareto front approximation might useful due number design objectives stated vast region objective space might impractical useless priori due strong degradation design objectives paper preference handling techniques incorporated optimisation process seeking improve pertinency approximated pareto front multi variable controller tuning inclusion preferences optimisation process order seek actively pertinent pareto front approximation approach possible tune multi variable controller fulfilling several design objectives using previous knowledge designer expected trade performance validated well known benchmark example multi variable control control tests show usefulness proposed approach compared tuning techniques elsevier ltd rights reserved
multi objective optimization antenna structures challenging task owing high computational cost evaluating design objectives well large number adjustable parameters design speed achieved means surrogate based optimization techniques particular combination variable fidelity electromagnetic simulations design space reduction techniques response surface approximation models design refinement methods permits identification pareto optimal set designs within reasonable timeframe study concerning scalability surrogate assisted multi objective antenna design carried based set benchmark problems dimensionality design space ranging six cpu cost antenna model min per simulation numerical results indicate computational overhead design process increases less quadratically number adjustable geometric parameters antenna structure hand promising result point view handling even complex problems
multiple object tracking fundamental step many computer vision applications however detecting tracking objects complex background still challenging task paper proposes approach combines improved gaussian mixture modeling gmm multiple particle filters mpfs automatic multiple targets detecting tracking gmm make improvement gmm phase model updating using expectation maximization algorithm recent frames weight parameters gaussian distributions tracking stage integrate multiple features targets including color edge depth mpfs improve performance object tracking comparing various particle filter approaches experimental results show approach track multiple targets complex backgrounds automatically accurately
multiple scan statistic usually used epidemiologist test uniformity clustering data article extend work lin give general expression moments multiple scan statistic circle use moments approximate distribution using markov chain compound poisson approximations proposed huffer lin lin numerical results presented evaluate performance approximations
multiple sclerosis chronic demyelinating disease central nervous system regarded one common causes neurological disability young adults exact etiology yet known although epidemiological data indicate genetic susceptibility environmental exposure involved poor vitamin status proposed attractive environmental factor several evidence highlighted importance mutations vitamin regulating genes vitamin status purpose study assess genetic variants vdbp cypb patients control group total subjects including patients healthy controls genotyped polymerase chain reaction followed restriction fragment length polymorphism analyses serum hydroxyvitamin levels measured patients controls high performance liquid chromatography observe statically significant difference distribution genotypic vdbp variants study groups plasma levels significantly higher control group versus patients patients carried showed lower plasma levels carried gcf showed higher levels observed wild type allele cypb mutations analyzed patients control group conclusion findings support role independent effect investigated vitamin related gene variants vdbp cypb risk
multiple sclerosis autoimmune disease affects hundreds thousands people world wide given autoimmune nature disease large part research focused autoreactive cells however research involvement myeloid cells pathophysiology received strong renewed attention recent years despite multitude inflammatory mediators involved innate immunity select group cytokines absolutely critical development cns autoimmunity among interleukin importance system experimental autoimmune encephalomyelitis eae recognized years recently begun understand plays multifaceted roles disease initiation development amplification chronicity review recent findings showing implication system eae introduce model highlights beta granulocyte macrophage colony stimulating factor csf interacting together create vicious feedback cycle cns inflammation ultimately leads myelin neuronal damage elsevier inc rights reserved
multiple sclerosis inflammatory disease central nervous system cns inflammation demyelination together axonopathy cardinal features pathologic ground combined genetic environmental background associations single nucleotide polymorphisms snps intron exon clinical manifestation south polish individuals including patients analyzed presence allele linked first manifestations disease diplopia pyramidal signs favored pyramidal signs protected diplopia development farther haplotype significantly favored whereas gtc protected diplopia besides gtt haplotype strongly favored non severe rrms outcome atc haplotype specific patients population based case control study investigating selected three snps revealed polymorphic variation may rather disease modifying risk factor elsevier rights reserved
multiple sodium hydrogen exchanger nhe isoforms expressed testes play various roles cell volume regulation intracellular regulation fluid absorption nhe recently characterized nhe family member detected leydig cells humans mice great abundance immunohistochemistry current study male mice lacking nhe expression infertile despite intact male reproductive organs male nhe mice smaller testes lacked spermatozoon seminiferous tubules epididymis age spermogonia seen testis nhe mice although male nhe mice normal serum levels luteinizing hormone follicle stimulating hormone serum testosterone level significantly reduced mice decreased expression luteinizing hormone receptor testes nhe small interfering rna transfected mouse leydig cells mltc silencing nhe decreased expression luteinizing hormone receptor similar moreover loss nhe function leydig cells resulted disorganized luteinizing hormone receptor membrane distribution therefore male infertility nhe mice least partially due disruption luteinizing hormone receptor distribution consequent low testosterone production leads sertoli cell dysfunction work identified novel role nhe male fertility effect modifying luteinizing hormone receptor function
multiple studies shown efficacy potentially curative effect catheter ablation however always accompanied considerable recurrence rate atrial fibrillation hypothesized pre procedure assessments baseline left atrial appendage emptying flow velocity laafv terminal pro brain natriuretic peptide probnp levels would help identify abnormal atrial substrate offer preliminary evidence regarding susceptibility recurrence patients paroxysmal persistent respectively patients paroxysmal persistent transesophageal echocardiography performed assessment laafv probnp measured first ablation months follow patients paroxysmal patients persistent experienced recurrence roc analysis probnp value paroxysmal persistent discriminated afr non afr greatest sensitivity specificity multivariate regression analysis laafv identified independent predictor afr paroxysmal population post adjustment risk factors however persistent population laafv probnp value identified independent predictors rhythm outcome compared parameters patients persistent elevated plasma probnp concentrations combined low laafv associated rhythm outcome ablation however laafv independent predictor efficacy patients paroxysmal
multipliers dividers provide two basic operations essential analog computers also many applications fuzzy control instrumentation analog signal processing automatic gain control frequency translation etc paper intended implement voltage multiplier divider using compensated log antilog amplifiers discuss design log antilog amplifiers problems involved log antilog amplifiers various causes may affect performance log antilog amplifiers finally different types compensation techniques log antilog amplifiers discussed designed voltage multipliers dividers simulation results analog signal multiplication division plotted using multisim
multirater multimethod multisource studies increasingly applied psychology eid colleagues proposed multilevel confirmatory factor model multitrait multimethod mtmm data combining structurally different multiple independent interchangeable methods raters many studies however different interchangeable raters peers subordinates asked rate different targets students supervisors leading violations independence assumption cross classified data structures present work extend cfa mtmm model eid colleagues cross classified multirater designs new model cross classified ctc combination methods accounts nonindependent interchangeable raters enables researchers explicitly model interaction targets raters latent variable using real data application shown credibility intervals model parameters different variance components obtained using bayesian estimation techniques
multi relational data mining rapidly growing area used mining relational databases traditional data mining approaches search patterns single data table relational data mining techniques look patterns exist multiple tables multi label learning classification comes multi relational data mining technique multi label learning instance linked multiple labels aim predict suitable label set unseen instance paper reviewed recent approaches multi relational data mining specific focus multi label classification furthermore critically evaluate prevalent techniques prediction class labels moreover propose conceptual model multi label learning using label ranking label correlation simultaneously proposed model works concurrently two modules first module label ranking used enhance classifier process ranking classes basis priority second module degree correlation data labels among training classes utilized enhance overall process multi label learning
multi rotors vehicles become consolidated reality modern aeronautical field small helicopters consist fuselage hanged set fixed pitch propellers powered electric motor vehicles great potentials research topic increasing aimed reduce structure weight maximize flight time range payload multi rotor components represent key challenge modeling optimization additive manufacturing mainly consist complex shapes important feature robustness lightweight usually produced small series example eight parts single prototype almost need able interface different materials work presented shows advanced research conducted cooperation altair engineering politecnico torino develop vital components structure multi rotor represent challenge main need interface arms consisting carbon fiber tubes motor frame made alloy use topology optimization techniques plays key role minimize weight components improve productivity machines moreover additive manufacturing fdm sharebot allows producing parts less time improving cost effectiveness project process described simple characterization anisotropic properties printed specimens fem analysis preliminary design component optimization phase performed altair optistruct code important role played altair tool used preliminary design inspire tool conceived generate structural efficient concepts quickly easily obtain lighter designs eliminate structural design problems finally provide input files printers authors published elsevier
multistate processes provide convenient framework interest lies characterising transition intensities set defined states however unobserved event interest known event occurs occurs stops future transitions multistate process occurring drawing inference joint multistate event process problematic health studies particular example could resolution resolved patient longer experience symptoms explored illustration multistate model includes state space original multistate process partitions state representing absent symptoms latent absorbing resolved state temporary transient state absent symptoms proposed expanded state space explicitly distinguishes resolved temporary spells absent symptoms disjoint states allows uncertainty knowing resolution occurred easily captured constructing likelihood observations absent symptoms considered temporary resulted resolution proposed methodology illustrated psoriatic arthritis data set outcome interest set intermittently observed disability scores estimated probabilities resolving also obtained model authors statistics medicinepublished john wiley sons ltd
multi task learning employs shared representation knowledge learning several instances problem multi step time series problem one challenging problems machine learning methods performance prediction model face challenges higher prediction horizons due accumulation errors cooperative coevolution employs divide conquer approach training neural networks promising single step ahead time series prediction recently evolutionary multi task learning proposed dynamic time series prediction paper adapt evolutionary multi task learning multi step prediction predictive recurrence developed feature knowledge previous states future prediction horizon goal paper present network architecture predictive recurrence capable mult istep prediction form multi task learning employ cooperative neuro evolution evolutionary algorithm baselines comparison results show proposed method provides best generalization performance cases comparison results literature shown promising motivates application approach related real world problems elsevier rights reserved
multitasking present activities daily living needs precise assessment allow ecological patient specific intervention use multitasking diagnostic tools remains rare due difficulties implementing laboratory settings overcome difficulties serious games represent good surrogate method offers possibility recreate functional setting safe daily living environment allows testing quantifying multitasking performances enjoyable motivating way purpose study investigate potential new serious game based multitasking assessment tool examining cognitive validity real life representability tool eighteen healthy elderly controls participated study asked execute cooking activity serious game real life assessed using neuropsychological test battery results showed performance virtual cooking task associated multiple cognitive measures performances virtual task highly representative participants real life tool first step toward including ecologically valid measures comprehensive assessment healthy elderly controls may help assesses elderly patients diseases alzheimer disease elsevier ltd rights reserved
multiversion databases store current historical data rows typically annotated timestamps representing period row valid develop novel techniques reduce index maintenance multiversion databases indexes used effectively analytical queries current data without heavy burden transaction throughput achieve end design persistent index data structures storage hierarchy employ extra level indirection indirection level stored solid state disks support fast random traversing extra level indirection incurs relatively small overhead extra level indirection dramatically reduces number magnetic disk needed index updates localizes maintenance indexes updated attributes additionally batch insertions within indirection layer order reduce physical disk indexing new records work exploit ssds introducing novel deltablock techniques storing recent changes data ssds using deltablock propose efficient method periodically flush recently changed data ssds hdds one hand keep track every change delta every record hand avoid redundantly storing unchanged portion updated records reducing index maintenance overhead transactions enable operational data stores create indexes support queries developed prototype indirection proposal extending widely used generalized search tree open source project also employed postgresql working implementation demonstrates significantly reduce index maintenance query processing cost factor insertion new records novel batching technique save insertion time updates prototype demonstrates significantly reduce database size even modest space allocated deltablocks ssds
muscle hernia focal protrusion muscle overlying subcutaneous tissue acquired congenital facial defect herniation thigh muscles common limited reports evaluating pathology using ultrasonography year old amateur football player presented palpable mass anterior aspect right thigh sonographic examination demonstrated fascial defect called mushroom appearance based clinical sonographic findings diagnosis rectus femoris muscle established today doubt anymore role musculoskeletal field sports injuries therefore various advantages non invasive practical convenient inexpensive etc key imaging method diagnosis mhs
muscle injuries frequently occur sport one commonest injuries diagnosis treatment muscle injuries impose high demands medical treatment order ensure successful regeneration rapid return sport injuries treated conservatively skeletal muscles high endogenous capacity repair regeneration conservative treatment includes initial field therapy known rice principle common recommended initial treatment sports injuries primary therapy target reduce pain swelling bleeding thus limit initial inflammatory process prevent damage first days injury brief immobilization helps reduce injury rate accelerates formation granulation tissue many possible additional treatments including intramuscular injections manipulation sacroiliac joint rehabilitation programs including stretching strengthening acute treatment phase complete days active treatment including trunk stabilisation stretching strengthening started gradually despite high prevalence studies treatment management injuries aim manuscript review literature classification pathobiology treatment strategies muscle injuries
mutations snca gene encodes alpha synuclein protein first discovered genetic causes familial parkinsonism lewy pathology date six different snca missense mutations well multiplications known cause parkinsonism review performed literature search identify published cases snca related parkinsonism provide updated summary clinical neuropathological features parkinsonism due snca mutations familial parkinsonism associated snca rare alpha synuclein aggregation core feature sporadic parkinsonism including parkinson disease dementia lewy bodies multiple system atrophy research alpha synuclein parkinsonism impacted define pathology understand pathogenesis parkinson disease related neurodegenerative disorders briefly discuss lessons learned research physiological role alpha synuclein pathological links neurodegeneration parkinsonism
mutations xpd ercc xpb ercc ttd gtfh genes involved nucleotide excision repair transcription cause several disorders including trichothiodystrophy ttd xeroderma pigmentosum study tested hypothesis mutations xpd gene affect placental development phenotype specific manner test hypothesis decipher potential biologic mechanisms compared xpd associated ttd cases reported literature respect frequencies gestational complications genetic epidemiologic investigations ttd revealed exact genetic abnormality relevant mechanism leading gestational complications preeclampsia structural mapping localized preeclampsia associated mutations terminal motif helicase surfaces xpd likely affecting xpd binding cdk activating kinase cak subunits transcription factor iih results suggested link ttd associated xpd mutations placental maldevelopment risk pregnancy complications possibly due impairment tfiih mediated functions placenta findings highlight importance fetal genotype development gestational complications preeclampsia therefore future studies genetic associations preeclampsia placental vascular complications may benefit focusing genetic variants within fetal dna european journal human genetics doi ejhg published online january
muwallads native neo muslims one groups played important role political social changes reign umayyads andalusia conversion islam called equal rights arab minority however political exclusion poverty economic pressure social racial discrimination applied arab umayyad rulers provided context rebellion initially muwallads began military struggle reign obtain rights conditions almost changed beginning third abul rahman governance imprinted peaceful politics well ethnic religious tolerance abdul nasser umayyad caliph son second sentence imprinted made opportunities muwallads participate political social structures andalusia society however meantime emphasizing ethnic identity cultural intellectual activities form praising advocating talent ability non arab arabs racial prejudice racial superiority addition gradually weakness umayyad rule andalusia formation independent states defensive mode changed offensive explicit denial arab race muwallads culminated shu ubiyya treatise ibn garasiah using analytical approach article intended first examine causes context formation shu ubiyya thoughts andalusia survey method quality writing treatises writings shu ubiyya end umayyad rule
myasthenia gravis autoimmune disease caused production antibodies acetylcholine receptors neuromuscular junction aim study ascertain oxidative stress accompanies estimation several independent parameters oxidative damage mainly levels oxidative modifications blood serum proteins group studied consisted patients females males ocular omg generalized gmg mean age years mean disease duration mean level nmol age matched healthy controls patients stratified groups according disease duration level low nmol well symptoms gmg omg glycophore fluorescence increased omg dityrosine increased types patients ill low high levels formylkynurenine increased omg gmg disease duration groups group low kynurenine increased group high tryptophan fluorescence decreased omg gmg patients ill iow high serum thiol group concentration decreased gmg patients ill aopp level elevated omg patients ill high protein carbonyls increased omg gmg patients ill low high frap abts scavenging fast antioxidants unchanged abts scavenging slow antioxidants lower omg gmg patients ill patients low high results demonstrate systemic oxidative stress suggesting therapeutic use antioxidants elsevier rights reserved
mycobacteria harbor two main degradative proteolytic machineries caseinolytic protease cippp proteasome recently showed bortezomib inhibits clppp exhibits whole cell activity mycobacterium tuberculosis bortezomib dipeptide boronic acid warhead human proteasome inhibitor approved cancer therapy boronic acid warhead compound shown drive potency human proteasome clppp protease selectivity bacterial clppp protease human proteasome lacking needs achieved move new anti tuberculosis lead forward study explored whether alternative warhead could influence bortezomib selectivity synthesized analog containing chloromethyl ketone instead boronic acid warhead determined potencies bacterial human enzymes surprisingly analog retained activity mycobacterial clppp active mycobacterial proteasome devoid activity human proteasome interrogation set chloromethyl ketone peptides identified three additional compounds similarly inhibiting clppp proteasome bacteria leaving human proteasome untouched finally showed compounds display bactericidal activity tuberculosis cytotoxicity ranging acceptable undetectable results suggest selectivity human proteasome achievable selectivity together dual targeting mycobacterial clppp proteasome makes new scaffold attractive starting point optimization
mycobacterium tuberculosis causative agent tuberculosis serious threat public health recent emergence extreme drug resistant strains worsened situation required serious efforts find better cure availability complete genome map various mycobacterium tuberculosis strains serves basis propose new therapeutic targets mycobacterium tuberculosis present study aimed identify characterize potential novel drug target mycobacterium tuberculosis using silico approach study consisted three phases phase subtractive comparative genomics performed genomic data strains mycobacterium tuberculosis comprised protein sequences analysis resulted three identical hypothetical proteins distinct origin shortlisted sequences non homologous host prerequisite characteristic potential drug target one sequences locus tag name cfbr cdc strain subjected bioinformatics methods phase phase shortlisted protein sequence qualitatively characterized subcellular localization functional family prediction evolutionary relationships predicted subcellular localization query protein found cytoplasmic region functional family classification resulted classifying protein transferase superfamily finally phase iii study structure based methods homology modeling docking performed build three dimensional structure predict putative binding site pdb found suitable template sequence identity binding site modeled protein deciphered dogsite scorer tool later probis tool used probe structurally similar binding sites protein data bank subsequently crystal ligands protein data bank structures prioritized high rank scores extracted cross docked binding site modeled protein cross docking results revealed two ligands deoxy aminopyridoxal phosphate two protein data bank structures mdo best docked rmsds respectively inferred protein structure identified protein alanine rich current study convincingly proposed shortlisted hypothetical protein potential drug target new drug candidates could designed hope cure tuberculosis
myeloproliferative disorders recently named myeloproliferative neoplasms mpn display several clinical entities chronic myeloid leukemia cml classical mpn including polycythemia vera essential thrombocythemia primary myelofibrosis pmf atypical unclassifiable nmp term mpn mostly used classical bcr abl negative myeloproliferative disorder pmf clonal diseases resulting transformation hematopoietic stem cell leading abnormal production myeloid cells genetic defects responsible myeloproliferative abnormalities called driver mutations result deregulation cytokine receptor jak stat axis among jak thrombopoietin receptor mpl calreticulin calr mutations found around cases driver mpn mutations associated driver mutations also found hematological malignancies especially pmfs chronic diseases major risks thrombosis hemorrhage cytopenias pmf long term progression myelofibrosis transformation leukemia recent therapeutic focused targeting jak signaling pathway directly inhibitors jak indirectly interferon allows cases hematologic molecular remission patients
myeloproliferative neoplasms mpns rare diseases include classic entities polycythaemia vera essential thrombocythaemia primary myelofibrosis short report minor allele frequencies common mpn mutations compared irish blood donor population populations european descent using data haplotype map project affymetrix array platform utilised identifying nine single nucleotide polymorphisms snps six proxy snps variability allele frequencies mpn mutations could account different incidence rates seen populations european ancestry giving better understanding genetic predisposition mpns copyright john wiley sons ltd
myeloproliferative neoplasms mpns expected increment number impose substantial economic social burdens end conducted nationwide population based descriptive epidemiology study also investigated medical cost associated mpns prevalence highest essential thrombocythemia range per followed polycythemia vera range per primary myelofibrosis pmf range per incurred highest cumulative total cost million frequent hospital visits pmf incurred highest average cost per person mean hemoglobin level males females analyses hemoglobin levels showed true positive rate significantly elevated hemoglobin group defined men women mpns provide biggest population based report mpn epidemiology readily used representative asian data
myeloproliferative neoplasms characterized common stem cell derived clonal proliferation phenotypically diverse jak mutated patients polycythemia vera approximately patients essential thrombocythemia primary myelofibrosis pmf pulmonary arterial hypertension pah major complication several hematological disorders chronic myeloproliferative disorders associated pah included group five etiology unclear multifactorial aim study screen egyptian philadelphia negative jak positive myeloproliferative neoplasm patients presence pah correlation jak allele burden also made review correlation jak allele hematological parameters comparing results others enrolled patients philadelphia negative myeloproliferative neoplasms patients enrolled study subjected laboratory imaging workup form cbc liver kidney profile bone marrow examination abdominal ultrasonography transthoracic echocardiography results revealed patients pulmonary arterial hypertension patients pmf patients prv patients correlation jak allele burden statistically significant correlation analysis jak allele burden parameters revealed statistical significant correlation age hct plt ldh splenic diameter insignificant correlation wbcs pah pulmonary arterial hypertension prevalence study significant correlation jak allele burden study largest one knowledge studies association prevalence jak burden
acetylglucosamine glcnac widely accepted treatment osteoarthritis however effect healthy individuals poorly understood evaluate effect glcnac administration healthy subjects exhibit symptoms arthritis present randomized double blind placebo controlled study performed present study male female japanese participants without symptomatic radiographic evidence enrolled randomly allocated receive placebo glcnac day weeks effects evaluated using biomarkers type collagen degradation synthesis collagen type cleavage procollagen type carboxy terminal propeptide piicp ratio piicp furthermore safety assessments performed via physical parameters hematology blood biochemistry urinalysis results indicated significant change biomarkers type collagen degeneration synthesis intervention placebo two glcnac groups however subgroup analysis using subjects impaired cartilage metabolism exhibited enhanced type collagen degradation reduced type collagen synthesis indicated levels significantly decreased weeks intervention two glcnac day groups compared placebo group contrast piicp levels notably different placebo two glcnac groups piicp ratio markedly decreased weeks intervention two glcnac groups compared placebo group moreover supplement related adverse events observed intervention conclusion observations indicate oral administration glcnac doses day improves cartilage metabolism healthy subjects without apparent adverse effects
nanoparticles wide range applications science technology size distribution nanoparticles one important statistical properties transmission electron microscopy tem ray diffraction commonly used characterization measuring particle size distributions manual analysis micrographs extremely labor intensive developed image processing algorithm measuring particle size distributions tem images presence overlapped particles uneven background approach based modified circular hough transform pre post processing techniques tem image improve accuracy increase detection rate nano particles application presented several images different noises uneven backgrounds lapped particles merits robust quantifying method demonstrated comparing results data obtained manual measurement algorithm allows particles detected characterized high accuracy elsevier ltd rights reserved
nanostructured materials relatively new class materials exhibit advanced mechanical properties thus improving performance capabilities products potential applications automotive aerospace defense industries among severe plastic deformation spd methods currently used achieving nanoscale structures accumulative roll bonding arb favorable method produce grain refinement continuous production metallic sheets bulk scale article model describes evolution material strength due processing via accumulative roll bonding developed arb experiments conducted grade selected set conditions results showed significant grain refinement microstructure similar two fold increase tensile strength compared received material developed model validated using experimental data exhibited good fit entire range arb processing cycles validate model ensure robustness wider array materials beyond review efforts arb processing carried five materials different initial microstructures mechanical properties even crystalline structures model still able capture strengthening trends considered materials society manufacturing engineers published elsevier ltd rights reserved
nanostructured metallic multilayers systems continue garner interest promising mechanical properties exploitable field materials engineering novel materials show high yield strengths anomalous young modulus values even superior radiation tolerance layer thicknesses tens nanometers however still many unknowns related deformation mechanisms operating nanoscale deformation mechanisms nanoscale depend directly layer thickness combination different similar crystal structures interface objective work produce multilayers investigate dependence deformation mechanisms layer thickness reduced nanoindentation hardness function periodicity lambda measured multilayers found decreasing yield strength values sigma increase lambda lambda sigma values almost constant gpa respectively whereas lambda yield strength shows decrease gpa mismatch sigma sigma cls values core cut alpha condition eta ratio eta indicates strain mechanism based cls occur period studied therefore strain mechanism based ibs suggested accord activation pyramidal slip system bar bar along layer even thickness thereby dislocation loop glide confined isolated layer changing plastic behaviour nano multilayer elsevier rights reserved
nanosystems based zero valent selenium biocompatible polymer stabilizers polyvinylpyr rolidone molecular weight poly trimethylacryloyloxyethylam monium methylsulfate polyethylene glycol studied means static dynamic light scattering resulting data compared dense spherical multimolecular nanosystems found formed morphological thermodynamic characteristics selenium containing nanosystems depending nature polymer stabilizer determined shown properties nanosystems adjusted varying molecular weight polymer stabilizer
narcissism lead various interpersonal problems however characteristics social decision making trait narcissism cognitive affective underpinnings poorly understood employed established game theoretical paradigms investigate different facets social behavior participants female mean age years wide range scores pathological narcissistic inventory interpersonal traits attitudes emotions assessed potential mediators behavioral differences high narcissism scores related lower generosity especially could result punished maladaptive behavior fully mediated reduced perspective taking abilities narcissism also narcissism scores predicted higher levels punishment behavior driven higher levels experienced anger hence difficulties narcissists face interactions may due reduced perspective taking skills resulting reduced generosity well enhanced anger based retaliation behavior published elsevier ltd
national media consumer panels conducted taiwan examine first person third person perceptions would mediate impacts celebrity credibility advertising skepticism results revealed third person perceptions took place context celebrity endorsed advertising three credibility variables negatively correlated advertising skepticism celebrity attractiveness expertise yielded direct effects indirect effects first person perceptions stronger third person perceptions advertising skepticism theoretical practical implication insights discussed indicate taiwanese consumers want recognized celebrity followers self enhancement purpose however first person perceptions played active role third person perceptions mediating perceived celebrity credibility diminishing skepticism toward celebrity endorsed advertising
naturally occurring nano structures much neglected potentially rich source products meet specifications imposed natural selection pharmaceutical industry long recognized value natural compounds emerging industries based nanotechnology far made little use free technology invented evolutionary time scales driven imperatives species survival ordered hexagonal packed array structures cicada pflatoda claripennis termite family rhinotermitidae wings investigated study spacings range structures tend rounded shape apex protrude surface plane wing structures spacings lower end range likely optimized serve anti reflective coating natural stealth technology may also act self cleaning coating lotus effect structures spacings upper end range may provide mechanical strength prevent load failure flight aid aerodynamic efficiency insect study demonstrates multi purpose design natural structures published elsevier
nature inspired algorithms becoming popular due ability solve complex optimization engineering problems grey wolf algorithm one recent nature inspired algorithms obtained inspiration leadership hierarchy hunting mechanisms grey wolves paper four formulations multi objective grey wolf algorithm developed using combination weighted objectives use secondary storage managing possible solutions use genetic algorithm formulations applied jobs scheduling parallel machines taking care criteria namely maximum tardiness weighted flow time empirically verified based multi objective grey wolf algorithms leads better results compared counterparts also use combination secondary storage improves resulting schedule proposed algorithms compared existing algorithms empirically found better results validated numerical illustrations statistical tests
negative attitudes major barrier equality people disabilities governments organizations implemented numerous programmes change attitudes towards people disabilities analyse published evidence effectiveness programmes using framework interrelationship among three levels policy intervention change attitudes personal level directed changing attitudes individuals organizational level concerning attitudinal barriers domains employment education health government level legally mandating behaviour change analysis finds following policy types effective used together policies involve direct contact people disability information awareness campaigns education training disability antidiscrimination enforcement policy characteristics contribute effectiveness include positive programme experience participants multifaceted prolonged interventions adequate programme resources policy effectiveness change attitudes relies corresponding reinforcement three policy levels
negative impedance converters nics proposed structures improve performance circuits electrically small antennas however nics suffer stability problems paper presents compact procedure analyze stability nics required sufficient conditions predict stability negative impedance converter given conditions evaluated using standard computer aided design software finally nic prototype given validate illustrate presented design procedure also integrated printed blade type electrically small monopole vhf band
negative parental attributions related parent family stressors thought important predictors subsequent disciplinary actions potentially abusive parenting examined negative parental attributions mediate relation daily stressors low ses parenting stress partner related stress parents history child maltreatment harsh abusive parenting mothers completed computerized attribution task reported daily stressors history child maltreatment discipline strategies mothers negative parental attributions mediated association parenting stress stressors harsh abusive discipline finding implicate interventions decrease risk child abuse focus reducing abuse related stressors also target negative parental attributions elsevier ltd rights reserved
negotiation convergence crucial part automated multi issue negotiation process improve negotiation convergence process minimize complexity agenda based approach used build new negotiation model agenda based model investigates significance choice sequence issue issue negotiation model improve agent utility providing efficient convergence effective equilibrium outcome main motivation construct new model symmetric pareto optimal proposed automated negotiation approach deals multiple issues way helps balance efficiency effectiveness outcome model analysed ambient intelligence domain order prove effectiveness
nematic liquid crystals nlcs proved excellent materials nonlinear optics applications large nonresonant nonlinearity extended spectral transparency demonstrate exemplary collision scenario optical solitons nematicons induced nonlinear refractive index nematic liquid crystals invoke hirota bilinearization method two coupled partial differential equations governing dynamics self focusing laser light nematic liquid crystal system believe type collision optical solitons nematicens reveals many possibilities optical switching schemes spatial demultiplexing network reconfiguration logic gates elsevier rights reserved
neonaticide infant murder occurring day birth case reports found literature often focused mother agent context pregnancy denial dissociative symptoms psychosis however report describes rare case attempted serial neonaticides acts committed nurse nursery referral hospital brazil authors describe forensic psychiatric evaluation criminal responsibility correlate information particular case relevant forensic themes namely neonaticide munchausen proxy syndrome serial healthcare killers
neospora caninum apicomplexan parasite recognized major bovine abortifacient dense granule antigens gras play important roles formation modification parasitophorous vacuoles pvs toxoplasma gondii however studies investigating gras reported caninum aim present study characterize dense gra gra caninum pvs using mdbk cells host cell model neospora caninum inoculated mdbk cells changes observed using transmission electron microscope tem neospora caninum gra gra identified characterized using bioinformatics cell fractionation immunofluorescence tem results revealed integrated pvs present mdbk cells caninum infection bioinformatics analysis showed ncgra ncgra shared homology gondii gra gra tggra tggra similar signal peptides transmembrane domains motifs cell fractionation subcellular localization analyses showed ncgra distributed lumen intravacuolar network soluble transmembrane forms transmembrane form ncgra observed membrane data lay foundation study bovine neosporosis ncgra ncgra function formation
network covert channels become sophisticated means transferring hidden information network covert channel internal control protocols also called micro protocols introduced recent years enhance capabilities network covert channels micro protocols usually placed within hidden bits covert channel payload enable features reliable data transfer session management dynamic routing network covert channels features provide adaptive stealthy covert communication channels micro protocol based tools exhibit vulnerabilities susceptible attacks paper demonstrate possible attacks micro protocols capable breaking sophisticated covert channel communication jeopardizing identity peers network attacks based attacker interaction micro protocol also present defense techniques safeguard micro protocols attacks using techniques micro protocol based tools become immune certain attacks lead robust covert communication present results two micro protocol based tools ping tunnel smart covert channel tool copyright john wiley sons ltd
network planning method widely used engineering construction accordance engineering construction management requirements especially project implementation process organization management present application project management especially supervision control tracking adjustment implementation plan lagging basically remains compilation plan analysis status quo application network technology implementation process paper puts forward methods methods application network planning technology
network traffic classification elementary network security management recent research tends apply machine learning techniques flow statistical feature based classification methods gaussian mixture model gmm based correlation flows exhibited superior classification performance also several important advantages robust distributional assumptions adaption cluster shape however performance gmm severely affected number clusters paper propose minimum description length mdl criterion balance accuracy complexity classification model effectively evaluating optimal number clusters establish new classification model analyze performance large number experiments carried two real world traffic data sets validate proposed approach results demonstrate efficiency approach
neurocutaneous melanosis ncm rare congenital syndrome characterized presence multiple congenital melanocytic nevi proliferation melanocytes central nervous system authors present year old chinese boy whose clinical manifestations intermittent headache months persistent abdominal pain days reconstruction computed tomography angiography image digital subtraction angiography magnetic resonance imaging plus angiography mri mra examinations results suggested cavernoma left frontal lobe potentially associated hemorrhage addition miliary abnormal signals widely scattered mra image malignant metastatic diseases ruled physical examination abnormal findings antispasmodic drugs ineffective antiepilepsy drugs effective abdominal pain surgery cavernoma noticed accumulation densely melanocytic mass located lesion radiology images lesions spread along perivascular sylvian veins leptomeningeal pathology investigation demonstrated brain metastatic malignant melanoma associated hemosiderosis lesion brain parenchyma totally removed spread lesions could treated surgery adjuvant radiotherapy performed failed control malignant development still patient died months postinitial operation authors conclude abdominal pain manifestation epilepsy related frontal lobe lesion neurocutaneous melanosis rare disease brain metastases result abdominal pain rare even worth attention clinicians
neurocysticercosis leading cause parasitosis central nervous system acquired epilepsy developing countries clinical manifestations neurocysticercosis especially racemose variant pleomorphic unspecific characteristics hinder diagnosis make challenge clinician objective report describe two cases racemose neurocysticercosis neuroimaging led definitive diagnosis first case involved patient persistent headache focal neurological signs required multiple paraclinical tests led definitive diagnosis racemose neurocysticercosis secondary cerebral vasculitis despite medical surgical treatment patient died multiple complications second case involved patient history neurocysticercosis consulted chronic intractable vomiting required multiple paraclinical tests led diagnosis vomiting central origin secondary racemose neurocysticercosis entrapment fourth ventricle medical surgical treatment patient showed slight improvement two cases evident proper interpretation neuroimages essential diagnosis racemose neurocysticercosis
neurodegenerative psychiatric diseases npds today important group diseases surpassing atherosclerotic cardiovascular disease cancer morbidity incidence although npds dramatic impact society high incidence mortality severe debilitating character remarkably effective interventions become available current treatments available comprise lifelong intake general immunosuppressants delay disease progression neurotransmitter antagonists agonists dampen undesired behaviors long term usage medication however coincides often severe adverse side effects therefore urgent need safe effective treatments diseases discuss many npds coincide subtle chronic flaring brain inflammation sometimes escalating infiltrations lymphocytes inflamed brain parts causing mild severe even lethal brain damage thus npds show features autoimmune diseases review postulate npds resemble autoimmune driven inflammatory diseases many aspects may belong disease spectrum like autoimmune diseases npd symptoms basically manifestations chronic self sustaining inflammatory process detrimental consequences patient specific inhibition destructive immune responses brain leaving patient immune system intact would ultimate solution cure patients disease reach goal primary targets primary self antigens psags patient chronic auto immune response need identified major npds immunological studies led identification psags involved autoimmune damage specific brain parts however research needed complete list psags npds immunological studies provide crucial insights npd pathogenesis also ultimately enable development new generation safe effective immunotherapies npds interventions dramatically improve life expectancy quality life individual patients moreover significantly reduce health care costs society general
neurofibromatosis type autosomal dominant neuro cutaneous skeletal syndrome neurofibromatosis type one rasopathies cellular level results hyperactive ras pathway current investigation aim study lateral skull rays cephalograms assess related craniofacial morphology total finnish patients including four patients plexiform neurofibroma cranial nerve age gender matched controls enrolled study results showed patients typically short mandible maxilla cranial base compared healthy controls irrespective age results statistically significant adults length mandible maxilla cranial base correlated height patients age correlation absent adult patients thus tall adult patient may short jaws short cranial base conclusion gene apparently influences growth craniofacial bones thus contributing craniofacial morphology
neuroimaging biomarkers differ patients early onset alzheimer disease eoad lateonset alzheimer disease load whether changes reflect cognitive heterogeneity differences disease severity still unknown study aimed investigating changes neuroimaging biomarkers according age onset disease mild amnestic alzheimer disease patients positive amyloid biomarkers cerebrospinal fluid patient groups impaired tasks assessing verbal visual recognition memory eoad patients showed greater executive linguistic deficits load patients showed greater semantic memory impairment eoad load hypometabolism involved bilateral temporoparietal junction posterior cingulate cortex eoad atrophy widespread including frontotemporoparietal areas whereas limited temporal regions load atrophic volumes greater eoad load hypometabolic volumes similar groups greater extent atrophy eoad despite similar extent hypometabolism could reflect different underlying pathophysiological processes different glucose based compensatory mechanisms distinct level premorbid atrophic lesions elsevier inc rights reserved
neuroimaging pathological gambling allows studying brain structure independent pharmacological neurotoxic effects occurring substance addiction high comorbidity substance use disorder sud first results structural deficits controversial current investigation first examine gray matter volume alterations controlling impact sud comparing non comorbid pgpure two comorbid pgalcohol pgpoly groups two hundred five individuals included analysis patients diagnosed healthy controls hcs employed voxel based morphometry look volume differences groups controlling age smoking depression decreases superior medial orbital frontal cortex occur independently substance use pgpure compared hcs frontal pattern decrease comparable pgalcohol group additionally volume decreased anterior cingulate increased amygdala moreover regions pgalcohol poly reduced volume medial frontal anterior cingulate occipital lobe regions pgalcohol poly exhibited structural deficits comparison hcs also relative pgpure precuneus post central gyrus demonstrated specific frontal cortex deficits without sud comorbidities whereas target regions reported earlier studies might result comorbid substance abuse seems core set frontal alterations associated addicted gambling behaviour independent toxic substance effects
neuroinflammation characterized activation glial cells observed various neurodegenerative diseases including alzheimer disease although reduction ether type glycerophospholipids plasmalogens pls brain reported patients mechanism reduction impact neuroinflammation remained elusive present study found first time various inflammatory stimuli reduced pls levels murine glial cells via kappa activation downregulated pls synthesizing enzyme glycerone phosphate acyltransferase gnpat increased myc recruitment onto gnpat promoter also found systemic injection lipopolysaccharide aging chronic restraint stress reduced brain pls contents associated glial kappa activation increase myc expression downregulation gnpat mouse cortex hippocampus interestingly reduction pls contents murine cortex could increase activated phenotype microglial cells expression proinflammatory cytokines suggesting acceleration neuroinflammation reduction brain pls similar mechanism gnpat reduction also found human cell lines triple transgenic mouse brain postmortem human brain tissues findings suggest novel mechanism neuroinflammation may explain prolonged progression help explore preventive therapeutic strategies treat neurodegenerative diseases
neurological disorders include wide variety mostly multifactorial diseases related development survival function neuron cells single nucleotide polymorphisms snps extensively studied neurological disorders number instances reproducibly linked disease risk factors rit gene recently shown associated number neurological disorders parkinson disease autism study reported investigated association snps rit gene essential tremor autism schizophrenia scz bipolar disorder bpd total patients controls using polymerase chain reaction restriction fragment length polymorphism pcr rflp method significant association observed two disorders whereas found associated autism scz bpd findings indicative differential association rit snps different neurological disorders
neuromedin nmu neuropeptide belonging neuromedin family recently reported significant association nmu breast cancer particularly correlating increased aggressiveness resistance targeted therapies overall significantly poorer outcome patients although mechanism exerts effect remained unexplained investigating found ectopic expression nmu positive breast cancer cells induced aberrant metabolism increased glycolysis likely due enhanced pyruvate dehydrogenase kinase activity similar results observed targeted drug resistant cell variants previously shown display increased levels nmu overexpression nmu also resulted upregulation epithelial mesenchymal transition markers increased secretion together aberrant metabolism associated cancer stem cell csc phenotype flow cytometry experiments confirmed nmu overexpressing targeted drug resistant cells showed increased proportion cells csc phenotype taken together results report new mechanism action nmu overexpressing breast cancer enhances resistance targeted drugs conferring csc characteristics expansion csc phenotype new cancer cells exhibit various metabolic adaptations contribute tumor aggressiveness drug resistance prerequisite stemness link metabolic abnormalities stemness cancer cells however fully understood increased stemness positive breast cancer cells associated overexpression neuromedin nmu neuropeptide functions energy homeostasis ectopic induced nmu overexpression resulted increases proportion cells cancer stem cell csc phenotypes key markers associated csc phenotype findings suggest nmu could valuable therapeutic target positive breast cancer
neuropsychological deficits executive functions linked antisocial behavior considered cardinal onset persistence severe antisocial aggressive behavior however psychopathy present prior evidence suggests dorsolateral prefrontal cortex unaffected leading intact ninety one male offenders antisocial personality disorder aspd controls completed wisconsin card sorting test wcst aspd individuals grouped three categories according psychopathy checklist revised pcl scores low medium high hypothesized aspd offenders high pcl scores differ healthy controls show better performance comparison subjects low pcl scores results showed aspd offenders low pcl scores committed perseverative errors responses controls offenders high pcl scores differ healthy controls moreover scores factor interpersonal facet pcl predictors better wcst performance results suggest modulatory role psychopathy cognitive performance aspd offenders provide evidence supporting offenders aspd psychopathy characterized cognitive profile different aspd without psychopathy elsevier ireland ltd rights reserved
neuroscience research examined separately detect human agents basis face body person perception reason thoughts traits intentions person knowledge neuroanatomically distinct networks associated person perception person knowledge remains unknown multiple features person thin kind linked form holistic identity representation fmri experiment investigated hypothesis encountering another person specialised person perception circuits would functionally coupled circuits involved person knowledge factorial design paired bodies names trait based neutral statements independent localiser scans identified body selective mentalising networks observing body paired trait implying statement functional connectivity analyses demonstrated body selective patches bilateral fusiform gyri functionally coupled nodes mentalising network demonstrate forming representation person circuits representing another person physical appearance linked circuits engaged reasoning trait based character data support view system social cognition involves communication perceptual inferential mechanisms forming representation another identity
neurosurgical interventions psychiatric disorders long troubled history become much refined last decades due rapid development neuroimaging robotic technologies advances enabled design less invasive techniques focused deep brain stimulation dbs dbs involves electrode insertion specific neural targets implicated pathological behavior repeatedly stimulated adjustable frequencies dbs used parkinson disease movement disorders since last decade applied treatment refractory psychiatric disorders evidence benefit obsessive compulsive disorder ocd major depressive disorder addictions recent consensus guidelines best practice psychiatric neurosurgery stress however dbs psychiatric disorders remains experimental exploratory stage ethics dbs particular psychiatric conditions debated much discourse surrounds philosophical implications competence authenticity personality identity change following neurosurgical interventions paucity applied guidance neuroethical best practice psychiatric dbs health care professionals expressed require paper aims redress balance providing practical applied neuroethical gold standard framework guide research ethics committees researchers institutional sponsors describe applied protocol particular research trial dbs severe enduring anorexia nervosa https clinicaltrials gov show nct unique identifier nct believe may wider application dbs psychiatric disorders
neurotrophic factors comprise broad family biomolecules peptides small proteins support growth survival differentiation developing mature neurons prototypical example best characterized neurotrophic factor nerve growth factor ngf widely recognized target derived factor responsible survival maintenance phenotype specific subsets peripheral neurons basal forebrain cholinergic nuclei development maturation addition active wide array non nervous system cells ngf also synthesized range cell types considered classical targets innervation ngf dependent neurons include cells immune haematopoietic lineage populations brain involved neuroendocrine functions ngf concentrations elevated numerous inflammatory autoimmune states multiple sclerosis chronic arthritis systemic lupus erythematosus mastocytosis conjunction increased accumulation mast cells intriguingly ngf seems linked also diabetic pathology insulin homeostasis mast cells ngf appear involved neuroimmune interactions tissue inflammation mast cells capable producing responding ngf suggests alterations mast cell behaviour could provoke maladaptive neuroimmune tissue responses including autoimmune nature moreover ngf exerts modulatory role sensory nociceptive nerve physiology adult appears correlate hyperalgesic phenomena occurring tissue inflammation ngf therefore viewed multifactorial modulator neuro immune endocrine functions
neutral beam injection nbi high power auxiliary heating system east device present thermal shield structure protect neck pipe east equatorial port avoid damage nbi beam since east port big trumpet structure straight section small trumpet structure accommodate port structure concept put forward including cooling system cooling loops sub branches designed interfaces inner cooling branches heat removal capability verified thermal hydraulics analysis based ansys code particular fabrication addressed technical processing technology especially embedded cooling pipes heat sinks pipes checked leaks bending embedding processing assembly activities demonstrated spatial space zones port engineering installation confirmed structure safe run feasibly east discharge indicated structure provide thermal shielding remove heat nbi device port region
new advances understanding pathophysiology vestibular migraine suggested large overlap migraine vestibular pathways explored regional distribution gray white matter abnormalities patients comparison migraine patients mwa without aura mwoa correlations patients clinical manifestations using tesla scanner brain weighted weighted mri scans acquired mwa mwoa age matched controls volumetric abnormalities estimated using voxel based morphometry spm compared controls migraine patients decreased volume left cerebellum increased volume left temporal lobe patients selective volume increase frontal occipital regions compared controls two groups migraineurs regions decreased volume compared mwoa mwa increased volume left thalamus regional abnormalities correlate disease duration attack frequency volumetric differences detected migraine patients controls results show volume abnormalities nociceptive multisensory vestibular brain areas occur patients overall findings suggest abnormal brain sensitization might lead dismodulation multimodal sensory integration processing cortical areas patients
new automated hematology analyzers led availability novel hematological parameters including immature platelet fraction ipf immature reticulocyte fraction irf potential interest patients myeloproliferative neoplasms mpns performed prospective analysis patients mpn including essential thrombocythemia polycythemia vera myelofibrosis ipf irf measured sysmex analyzer compared patients higher ipf irf observed among patients factors associated high ipf among patients male sex thrombocytopenia diagnosis among patients elevated peripheral blasts low platelet count jak mutation previous therapy factors associated high irf among patients low hemoglobin high reticulocyte count diagnosis among patients peripheral blasts elevated reticulocytes ipf irf represent novel parameters patients mpn potential relevant clinical implications comparison healthy subjects secondary polycythemia needed confirm preliminary findings
new current mode high order pole elliptic filters employing second generation third generation current conveyors presented paper synthesis method based signal flow graph design simulating passive ladder filters simple architectures obtained along grounded resistors capacitors pole filter design moreover numbers resistors capacitors current conveyors proposed pole filters equal numbers filter order proposed elliptic filter designed adding floating capacitor corresponding nodes pole filter counterpart third order current mode chebychev elliptic lowpass filters demonstrated verify proposed method
new double layered electromagnetic absorbers presented paper new absorbers composed one lossy left handed material absorbing layer one impedance matching layer consisted lossless right handed material indicated reflection loss obtained frequency range ghz ghz power attenuation achieving narrow frequency band electromagnetic absorbers also obtained modulate permittivity right handed material furthermore thickness whole absorbing structure particularly helpful practical applications presented results reference significance accurate design new electromagnetic absorbers practical prospects stealth technology
new information communication technology ict teaching enabling technology possibility increased learning outcome engineering education paper identifies possible factors enable inhibit teachers use ict teaching practice results based seven semi structured interviews conducted amongst teachers manufacturing engineering education analytical framework derived main research study international education monitoring project study framed use actor network theory study shows leadership administration great influence tools selected aiding teaching processes led increased use non use ict teaching practice controlling students also seem like encouraging factor using technology teaching authors published elsevier
new sources electrical energy made technically feasible allow small scale electrical generation facilities make much larger percentage electrical system energy sources past however complexities electrical generator transmission transaction may act inhibit investment potential independent power producers critical issues prospective investors terms access wheeling lights questions relating dependency opportunism destructive competition may difficult resolve satisfactory manner suboptimal levels investment alternative energy sources result
new species discoveries rediscovery species considered extinct extirpated good news yet prospects long term survival may bleak remnant populations small isolated discovered species commonly rare cryptic data inform appropriate conservation actions usually sparse demonstrate make available data using recent rediscovery ghana sitatunga tragelaphus spekei illustrative case study sitatunga thought extinct ghana years rediscovered science avu lagoon little known species especially west african populations given cryptic nature inaccessible wetland habitat approach maximizing insights given limited data first paired observations occurrence landscape characteristics derived open access remote sensing data creating first ever habitat suitability model sitatunga model served elucidate habitat preferences assess possible existence connectivity remnant populations elsewhere ghana estimate maximum total effective population size moreover timing occurrence sightings provided insights behavior sitatunga sightings rare heavily male biased mostly occurred suitable habitat limited suggesting habitat near avu lagoon insufficient ensure long term population viability existence connected populations ghana improbable without continued protection possibly additional interventions augment population numbers gene flow sitatunga avu lagoon likely extinct case study demonstrates conservation challenges associated rediscovery relict populations utility applying tools habitat suitability models sparse data moreover research stresses need implement immediate conservation action upon species discoveries prevent regional extinction
new styles created modifying existing ones order formalize style change using grammars style formally defined design language grammar previous studies use grammars style change give explicit rationale transformation would designers decide rules modify grammar generate necessary changes style designs paper addresses aforementioned issues presenting framework strategic style change using goal driven grammar transformations framework employs style description scheme constructed describing aesthetic qualities grammar elements using adjectival descriptors present techniques formal definition style designs generated grammars utility grammar transformation framework style description scheme tested example mobile phone design analyses reveal constraining rules grammars valid technique generating designs dominance desired adjectival descriptors thus aiding strategic style change
new voltage mode electronically tunable notch bandpass highpass lowpass shadow filters presented filters built around current feedback operational amplifier case one parameters filter electronically controlled adjusting gain external amplifier built around current feedback operational amplifier contrary current mode shadow filters summing junction must used summing amplifiers used voltage mode realizations experimental results obtained using current feedback operational amplifier presented results obtained confirm functionality proposed circuits
new zealand farming relies heavily grazed pasture feeding livestock therefore important provide high quality palatable grass order maintain profitable sustainable grassland management presence non photosynthetic vegetation npv dead vegetation pastures severely limits quality productivity pastures quantifying fraction dead vegetation mixed pastures great challenge even remote sensing approaches study high spatial resolution pixel resolution spectral resolution imaging spectroscopy data aisafenix used assess fraction dead vegetation component mixed pastures hill country farm new zealand used different methods retrieve dead vegetation fraction spectra narrow band vegetation indices full spectrum based partial least squares pis regression feature selection based pls regression among approaches feature selection based pls model exhibited better performance terms prediction accuracy rmsecv rpdcv results consistent validation data also performed well external test data rmse rpd addition statistical tests conducted ascertain effect topographical variables slope aspect accumulation dead vegetation fraction steep slopes degrees significantly higher amount dead vegetation contrast aspect showed nonsignificant impact dead vegetation accumulation results study indicate aisafenix imaging spectroscopy data could useful tool mapping dead vegetation fraction accurately elsevier rights reserved
new zealand kauri agathis australis lindl large long lived tree species endemic species rich forests north north island agathis australis culturally ecologically significant little known ecophysiology particular environmental drivers fluxes carbon water australis trees quantified measured leaf gas exchange explore effect leaf age tree size foliar nitrogen concentration photosynthetically active radiation par vapour pressure deficit assimilation rates stomatal conductance also measured carbon isotope discrimination leaves applied optimal stomatal behaviour model highest year one leaves mmolm molm respectively declined leaf age mmolm molm respectively year old leaves instantaneous water use efficiency highly variable leaf age related pattern diurnal results indicate australis peaks early day mmolm comparatively low remaining molm throughout day overall water use efficiency low based intrinsic water use efficiency stomatal model isotopic analysis indicated moderate water use efficiency life leaves compared temperate conifers information valuable modelling carbon water fluxes australis improving understanding threat summer droughts forest giants
news media raise public awareness health influence public policy agenda recently nephrologists sought make prevention early detection chronic kidney disease ckd health care priority assessed extent manner australian television news newspapers cover ckd prevention early detection electronic news databases print media television programs searched may march items referring ckd prevention early detection analyzed relevant items spokes people main news frame focus responsibility proposed solutions trigger reason publication newspaper articles television broadcasts retrieved articles broadcasts eligible kidney transplantation dominated ckd related news lay person high profile advocates virtually absent risks cardiovascular disease mortality conferred ckd emphasized news reports instead ckd received peripheral mention secondary consequence diabetes obesity reports cited economic consequences ckd media focused lifestyle causes solutions whereas nonlifestyle causes screening prevention strategies rarely mentioned kidney health professionals need actively engage media efforts amplify desired messages ckd prevention early detection medical journals research institutions universities hospitals advocacy groups issue press releases highlight newsworthy aspects topic extending news media coverage help exert influence health policies agenda setting increase public awareness improve prevention early detection ckd
next generation mobile systems implement one dream anywhere anytime communications providing global coverage mobility satellite systems play important role order achieved design options satellite systems include several choices basic ones choice orbit processing switching intersatellite links link layers technologies addition network architecture protocols must developed efficient use satellite radio resources important protocol design issues concentrate medium access control mac techniques routing traffic management paper special features satellite systems considered emphasis given mac protocols design well research programmes led development finally adaptive hybrid access scheme combines cdma technology random access techniques presented new scheme called cdma prma results obtained promising access technique next generation satellite systems copyright john wiley sons ltd
next generation sequencing led identification many potential novel disease genes presence mutations gene multiple unrelated patients however priori insufficient establish genes truly involved respective disease show phenotype information incorporated within statistical approaches provide additional evidence causality mutations developed broadly applicable statistical model integrates gene specific mutation rates cohort size mutation type phenotype frequency information assess chance identifying novo mutations affecting gene multiple patients shared phenotype features demonstrate approach based frequency phenotype features present unique cohort patients intellectual disability show combined approach decrease number patients required identify novel disease genes especially patients combinations rare phenotypes conclusion show integrating genotype phenotype information aid significantly interpretation novo mutations potential novel disease genes wiley periodicals inc
nicandra physaloides traditional folk medicine china seeds used make jelly phytochemical investigation active ethyl acetate etoac extract fruits led isolation identification two new phenolic amides hydroxy dimethoxyphenyl hydroxy methyl hydrxyphenyflethyl carbamoyletheny methoxybenzodihydrofuran cisn phydroxycinnamoyl methoxyethyltyramine together twelve known compounds structures determined basis spectroscopic analyses compounds reported genus nicandra first time compounds investigated protective effects methyl phenylpyridiniumion mpln induced damage human dopaminergic neuroblastoma cells syy compounds showed significant protective activities certain concentration cell protection mechanism compound proved inhibiting mppt induced apoptosis inducing cytoprotective autophagy parkinson disease herein plausible biosynthetic pathway compounds also discussed study suggested phenolic amides potential candidate drugs treating fruits physaloides could used functional food ingredient improve symptoms memory loss possibly prevent treat elsevier ltd rights reserved
nicotine primary addictive component tobacco products complex stimulus effects readily discriminated human non human animals previous research rodents directly investigating nature nicotine stimulus limited males current study began address significant gap literature training female male rats discriminate nicotine saline discriminated goal tracking task task access sucrose intermittently available nicotine session interspersed saline session sucrose available sexes acquired discrimination evidenced increased head entries sucrose receptacle goal tracking evoked nicotine nicotine generalization curves also similar females males pharmacological profile nicotine stimulus assessed using substitution targeted combination tests following ligands sazetidine pha pnu bupropion nicotine cytisine females males nornicotine fully substituted nicotine stimulus whereas sazetidine bupropion cytisine evoked partial substitution female male rats responded similar manner interaction tests combination sazetidine plus nicotine nornicotine shifted nicotine dose effect curve left combination sazetidine plus bupropion cytisine failed findings begin fill significant gap scientific literature studying nature nicotine stimulus response therapeutically interesting combinations using model includes sexes elsevier ltd rights reserved
night eating syndrome nes commonly assessed using night eating questionnaire neq validated scale symptom severity assess diagnostic criteria night eating diagnostic questionnaire nedq assesses diagnostic criteria fully validated study purpose establish convergent validity nedq neq also expected higher nedqscores would associated elevated depression poorer sleep quality food addiction bmi studies nes students community members administered neq nedq pittsburgh sleep quality index zung self report depression scale sds yale food addiction scale yfas convergent validity nedq neq demonstrated scores significantly positively correlated good agreement nedqand neq diagnosis nes diagnosed nedq met threshold score neq participants met neq threshold score nes meet nedq diagnostic criteria manova revealed higher nedq associated higher sds yfas scores poorer sleep quality full syndrome nes nedq associated higher bmi community group unlike student group scores questionnaires higher community group discrepancies nedq neq diagnosis may due differences construction questionnaires specifically due nedq designed diagnosis neq provides convenient global score nes severity whereas nedq shows convergent validity neq provides clinically useful diagnostic categories elsevier ltd rights reserved
nitrate pollution groundwater mainly caused application nitrogen based fertilizers intensive agriculture widespread problem world potential risk public health reverse osmosis ion exchange electrodialysis currently used water denitrification yielding highly concentrated reject water requires economic environmental costs disposal nitrate reduction technologies able convert nitrate inert nitrogen gas appeared promising cost effective environmentally friendly among technologies attention focused chemical reduction mono bimetallic catalysts hydrogen reducing agent electrocatalytic reduction processes metallic anodes although selectivity values towards greater achieved technologies undesired formation ammonium reaction product still main drawback preventing implementation larger scales reason development new catalytic electrodic materials well novel reactor configurations avoid ammonium formation extensively investigated last years increase effectiveness competitiveness technologies paper overview current state art catalytic reduction electroreduction nitrates presented highlighting potential main drawbacks along guidelines future research elsevier rights reserved
nitrite supplementation limits hypoxia induced oxidative stress activates alternate pathway may partially account nitrite mediated cardioprotection sensitive selective biosensors point care devices need explored detect physiological nitrite level due important role human pathophysiology work cytochrome reductase ccr biofunctionalized self assembled monolayer sam functionalized gold nanoparticles gnps polypyrrole ppy nanocomposite onto screen printed carbon electrode spce investigated biosensor detection nitrite based electrochemical catalytic properties ccr covalently coupled sam layers gnps using edc nhs direct electrochemical response cer biofunctionalized electrodes showed couple well defined nearly reversible cyclic voltammetric peaks agcl optimal conditions biosensor could used determination linear range detection limit sensitivity designed developed novel cost effective portable electrochemical analyzer measurement hypoxia induced cardiac cells using arm microcontroller results obtained using developed portable electrochemical nitrite analyzer also compared standard cyclic voltammetry instrument found agreement
nitrogen deposition expected great impact forest ecosystems affecting many aspects plant environmental interactions one involves influences plant water relations modifications plant hydraulic architecture however surprising lack integrative study tree hydraulic architecture responses deposition especially whole plant level present study used year addition experiment simulate effects six different levels deposition year growth whole plant hydraulic conductance dominant tree species fraxinus mandshurica rupr typical temperate forest china results showed alleviation limitation moderate concentrations fertilization year promoted plant growth additions top threshold level showed negative effects plant growth growth responses mandshurica seedlings addition different concentrations accompanied corresponding changes whole plant hydraulic conductance higher growth rate accompanied reduced whole plant hydraulic conductance plant higher leaf water use efficiency detailed analysis hydraulic conductance different components whole plant water transport pathway revealed changes root leaf hydraulic conductance rather stem responsible plant responses fertilization plant growth hydraulic architecture responses increasing levels addition linear correlation measured parameters availability exhibited bell shaped curves peak values observed medium levels fertilization changes hydraulic architecture response fertilization found present study may represent important underlying mechanism commonly observed changes water related tree performances response deposition
nmrfx processor new program processing nmr data written java programming language nmrfx processor cross platform application runs linux mac windows operating systems application run graphical user interface gui mode command line processing scripts written python programming language executed low level java commands automatically run parallel computers multiple cores cpus processing scripts generated automatically parameters nmr experiments interactively constructed gui wide variety processing operations provided including methods processing non uniformly sampled datasets using iterative soft thresholding interactive gui also enables use program educational tool teaching basic advanced techniques nmr data analysis
statistical data available number employees working night shifts turkey working shifts associated decreased sleep time decreased daily sleep quality decreased alertness night shifts increased incidences cardiovascular disorders peptic ulcers types cancer shift workers well known exposure light nighttime suppresses melatonin production non synchronized circadian rhythm disturbed melatonin secretion may lead excessive sleep hunger carbohydrates weight gain melatonin hormone governs sleep seems key regulator sleep wake rhythm exposure light night disturbance circadian rhythm contribute health problems night shift workers disturbing melatonin production review definitions social jetlag delayed sleep phase syndrome insomnia discussed sleep disorders psychiatric diseases reviewed melatonergic drugs available market listed including contraindications side effects physiopathology sleep sleep disorders depression melatonin given extended discussion two recent reviews effect melatonin sleep patterns discussed finally treatments sleep disorders summarized conclusion shift workers sleep problems complex subject multiple pathophysiological mechanisms play roles double blind randomized controlled studies systematic reviews meta analyses conducted provide weakly positive data beneficial effect melatonin use shift workers future multi centered multi participant studies shed light issue
noise optimization challenging problem nanoscale metal oxide silicon field effect transistor circuits brief presents technique uses transconductance drain current dependent transistor noise parameters explore design space evaluate tradeoff decisions expression corner frequency folded cascode amplifier derived design process demonstrated brief using folded cascode amplifier applicable wide class amplifier circuits
nomics anthropology ethics healthcare concept value deeply rooted economic theory dating back mid seventeenth century formally applied scottish economist adam smith inquiry nature causes wealth nations economy diversified one based commodities revisions theory value come often modem economy value tied directly cost object include cost production distribution exchange consumption however strict economic definition value refined sector relevant healthcare value involves preferences patient consumer cost financial risk toxicity exchange individuals tradeoff within individual context exchange patient terminal illness seen discussion value regardless perspective political societal implications review aim define value gynecologic cancer care demonstrate importance value provision care discuss value impacts government relations payors provide examples intersection value delivery gynecologic cancer care
nonaccidental head injury seen domestic child abuse cases often associated spinal injury spinal subdural hematoma frequent diagnosis spinal epidural hematomas rare occurrence incidence spontaneous epidural hematomas occurring nonaccidental head injury patients even lower epidural hematomas often result acute focal neurological deficits necessitating emergent neurosurgical intervention patients without focal neurological deficits conservative management may allow spontaneous resolution epidural hematoma authors present case year old boy large spinal epidural hematoma resulting event nonaccidental injury specifically domestic child abuse patient exhibited focal neurological deficits managed conservatively without surgical clot evacuation follow visit repeat imaging studies demonstrated stable resolution spinal epidural hematoma providing support safety conservative management patients karger basel
non accidental trauma significant source morbidity mortality pediatric population given vulnerable state child radiologist often provide valuable diagnostic information setting suspected abuse review focuses common findings abusive trauma serves guide aid clinical decision making providers emergency medicine pediatrics amid discussion assessment modern controversies regarding reported mimicking pathologies recapitulation current state evidence respect radiologic findings abuse examination contribution spine imaging may add diagnosis possible abusive head trauma acutely injured child recommendations avoiding pitfalls regarding dating intracranial injuries discussed illustrated depictions perpetrator induced pathology provided aid understanding injuries use appropriate approach imaging evidence based guidelines regarding radiologic findings role radiology provide fundamental clues diagnose prevent recurrence abusive injury patients speak
non alcoholic steatohepatitis nash characterized lobular inflammation hepatocellular ballooning may associated liver fibrosis leading cirrhosis complications pharmacological approach necessary treat nash failure change dietary habits lifestyle patients insulin resistance increased release free fatty acids oxidative stress activation inflammatory cytokines seem key features disease progression thiazolidinediones pioglitazone antioxidant agents vitamin first pharmacological options evaluated nash recent years several new molecules target different pathways related nash pathogenesis liver metabolic homeostasis inflammation oxidative stress fibrosis developed obeticholic acid int elafibranor gft provided promising results phase iib randomized placebo controlled clinical trials evaluated ongoing phase iii studies potential treatments nash investigation phase studies phase diversity possible treatments calls better understanding nash order enrich trial populations patients susceptible progress respond manuscript aims review pharmacological nash treatment landscape
non celiac gluten sensitivity ncgs sometimes known non celiac wheat sensitivity ncws recently received much attention scientific well alternative medical community past years publications ncgs indexed pubmed database gluten free market growing bigger clear number consumers gluten free diet gfd possibly suspicion ncgs appears grow even faster nevertheless despite three rising events many questions ncgs remain unresolved likely ncgs represents heterogeneous group disorders linked common response gfd still fully understood gluten likely wheat proteins components could activate drive pathophysiology ncgs result still clear biomarkers robust clinical diagnostic criteria conclusive definition ncgs heterogeneity approached reducing variables particular human behaviour placebo effect studying animal models address specific biological effects wheat andlor gluten related proteins ficrein review animal models potential used advance understanding disorders potentially address prevention treatment
non destructive controls particularly rays computed tomography useful tool manufacturing engineering applications modern industry study texture deformation mechanical parts efficient way manufacturing processes relationships mechanical properties materials structure also composition crucial design mechanical parts basically influence general behaviour parts service conditions therefore great interest possibility viewing high resolution transversal plane object without destroying controlled parts moreover ray tomography supplants ultra sound spatial resolution attenuation measure well adapted study material paper gives comparative study new developments non destructive controls composite materials applications manufacturing engineering also reviews essentially performance advantages rays computed tomography medical scanner usage multiple scales macro micro meso nano method also terminology subsequently deal chosen materials share performances technique different industrial applications elsevier rights reserved
nonlinear system identification vast research field today attracting great deal attention structural dynamics community ten years ago mssp paper reviewing progress achieved concluded identification simple continuous structures localised nonlinearities within reach past decade witnessed shift emphasis accommodating growing industrial need first generation tools capable addressing complex nonlinearities larger scale structures objective present paper survey key developments arose field since illustrate state art techniques using real world satellite structure finally broader perspective nonlinear system identification provided discussing central role played experimental models design cycle engineering structures elsevier ltd rights reserved
nonlocal integral gradient enhancements widely used resolve mesh dependency issue standard continuum damage models however reported whereas structural response mesh independent spurious damage growth observed accordingly class modified nonlocal enhancements developed literature interaction domain increases damage contribution adopt contrary view interaction domain decreases damage motivated fact fracture quasi brittle materials typically starts diffuse network microcracks localizing macroscopic crack ensure thermodynamics consistency micromorphic theory adopted model development ensuing microforce balance resembles closely helmholtz expression conventional gradient damage model superior performance localizing gradient damage model demonstrated one dimensional problem well mode failure plane deformation three cases localized deformation band material failure obtained copyright john wiley sons ltd
non malleable codes defined dziembowski pietrzak wichs ics provide roughly following guarantee codeword encoding message tampered equal tampered message contained reveals information nonmalleable codes applications immunizing cryptosystems tampering attacks related key attacks one efficient non malleable code protects efficient tampering functions however paper show next best thing polynomial bound given priori efficient non malleable code protects tampering functions computable circuit size generally family tampering functions size vertical bar vertical bar efficient non malleable code protects element rate codes defined ratio message codeword size approaches results information theoretic main proof technique relies careful probabilistic method argument using limited independence result get efficiently samplable family efficient codes random member family non malleable overwhelming probability alternatively view result providing efficient non malleable code common reference string model also introduce new notion non malleable key derivation uses randomness derive secret key way even tampered different value derived key reveal information results non malleable key derivation analogous non malleable codes useful tool analysis rely notion leakage resilient storage davi dziembowski venturi scn result independent interest also significantly improve parameters schemes
non malleable coding introduced dziembowski ics aims protecting integrity information tampering attacks situations error detection impossible intuitively information encoded non malleable code either decodes original message presence tampering unrelated message non malleable coding possible class adversaries bounded size particular dziembowski show codes exist may achieve positive rates class tampering functions size constant however result existential thus attracted great deal subsequent research explicit constructions non malleable codes natural classes adversaries work consider constructions coding schemes two well studied classes tampering functions namely bit wise tampering functions adversary tampers bit encoding independently much general class split state adversaries two independent adversaries arbitrarily tamper half encoded sequence obtain following results models bit tampering adversaries obtain explicit efficiently encodable decodable non malleable codes length achieving rate error also known exact security alternatively possible improve error cost making construction monte carlo success probability still allowing compact description code previously best known construction bit tampering coding schemes due dziembowski ics monte carlo construction achieving rate close initiate study seedless non malleable extractors natural variation notion non malleable extractors introduced dodis wichs stoc show construction non malleable codes split state model reduces construction non malleable two source extractors prove general result existence seedless non malleable extractors implies codes obtained reduction achieve rates arbitrarily close exponentially small error separate recent work authors show optimal rate model currently best known explicit construction split state coding schemes due aggarwal dodis lovett eccc achieves vanishing polynomially small rate
non primate hepacivirus nphv corresponds group isolates recently characterized horses dogs present similar genomic organization closely related hepatitis virus since canine hapacivirus nphv identified dogs first discovered dogs united states equine hepacivirus eqhv nphv identified horses identified horses several countries however epidemiological studies investigated eqhv horses korea study total serum samples collected horses four regions korea tested eqhv rna using nested pcr overall samples identified positive analyzed according gender age breed region high positive rates males young horses thoroughbreds however rates differed regionally sequencing partial region samples polyprotein encoding regions two samples positive eqhv rna revealed korean eqhv isolates shared approximately homology nucleotide deduced amino acid level respectively phylogenetic analysis revealed partial genes clustered sequences previously reported nphv notably sequences eqhv detected horses region showed sequence divergence sequences polyprotein encoding region two representative eqhvs shared homology nucleotide deduced amino acid level respectively comparison sequences polyprotein encoding regions korean eqhv isolates hepaciviruses different hosts revealed nsb regions conserved among hepaciviruses results present study demonstrate high positive rate eqhv korea provide significant information regarding geographical distribution genetic variability korean eqhv isolates help improve global epidemiology eqhv elsevier rights reserved
nonsense mediated mrna decay nmd plays important role eukaryotic gene expression yet scope defining features nmd targeted transcripts remain elusive address issues reevaluated genome wide expression annotated transcripts yeast cells harboring deletions upf upf upf genes new rna seq analyses confirm previous results microarray studies also uncover hundreds new nmd regulated transcripts escaped previous detection including many intron containing pre mrnas several noncoding rnas vast majority nmd regulated transcripts normal looking protein coding mrnas bioinformatics analyses reveal set nmd regulated transcripts generally lower translational efficiency higher ratios frame translation nmd regulated transcripts also lower average codon optimality scores higher transition probability nonoptimal codons collectively results generate comprehensive catalog yeast nmd substrates yield new insights mechanisms transcripts targeted nmd
nonvolatile spintronic devices potential advantages fast read write high endurance together back end line compatibility offers possibility constructing stand alone rams embedded rams used conventional vlsi circuits systems also standby power free high performance nonvolatile cmos logic employing logic memory architecture advantages employing spintronic devices especially magnetic tunnel junction mtj devices cmos circuits discussed current status mtj based vlsi computing paradigm presented along prospects remaining challenges
north karnataka one regions high prevalence hiv individuals bijapur district north karnataka high prevalence per fact sheets naco march better awareness access health care antiretroviral therapy improved survival increase number people living hiv aids plha improved survival increased attendance hospitals variety surgical problems known less known percentage hiv individuals among admissions individuals surgical problems abscesses commonest abscesses uncommon sites also encountered anorectal pathologies tuberculosis lymphadenopathy appendicitis etc commonly seen hiv individuals seen drug induced pancreatitis due anti retroviral therapy one common problems encountered uncommon conditions like ureteric calculi external iliac artery thrombosis diaphragmatic eventration observed even though literature aids hiv abundant less information surgical conditions encountered part subcontinent hence decided report profile conditions encountered
northeastern mexico semiarid region water scarcity strong pressure water sources caused rapid increase population industrialization region rainwater harvesting alone enough meet water supply demands due irregular distribution rainfall time space thus study reliability integrating rainwater harvesting greywater reuse reduce water consumption minimize wastewater generation tecnologico monterrey monterrey campus assessed potable water consumption greywater generation main facilities campus determined rainwater potentially harvested roofs parking areas campus estimated based statistical analysis rainfall based data potential water savings wastewater minimization determined characterization rainwater greywater carried determine treatment necessities water source additionally capacity water storage tanks estimated selected treatment systems economic assessment conducted determine viability alternatives proposed results showed water consumption reduced wastewater generation minimized implementation rainwater harvesting greywater reuse systems monterrey campus generate important economic benefits institution amortization investments achieved six years net present value npv order internal rate return irr benefits investment ratio seventh year project present irr greater minimum acceptable rate return marr decade irr twice marr npv denoting economic feasibility based results clear integrating rainwater harvesting greywater reuse resulted feasible reliable strategy strategies based rainwater harvesting furthermore investments amortized shorter period time
nosql data stores emerged last years solution provide scalability flexibility data modelling operational databases data stores proven better suited kinds problems relational databases order scale relaxed properties provided relational databases mainly transactions however transactional semantics still needed applications paper describe coherentpaas provides scalable holistic transactions across sql nosql data stores document oriented data stores key value data stores graph databases
novel diagnostic criteria alzheimer disease incorporate biomarkers maturity implementation clinical practice prodromal stage mild cognitive impairment mci unclear evaluate cerebrospinal fluid csf beta amyloid beta total tau phosphorylated tau light phase framework biomarker development ample evidence available phase identifying useful leads phase assessing accuracy dementia versus controls csf biomarkers phase utility mci partially achieved cohorts long follow time csf beta total tau phosphorylated tau high diagnostic accuracy mci due phase performance real world ongoing phase studies quantify impact costs come results highlight priorities pursue enable proper use csf biomarkers clinic priorities reduce measurement variability introduction fully automated assay systems increase diagnostic specificity toward non neurocognitive diseases mci stage clarify role csf biomarkers versus biomarker modalities clinical practice design clinical trials efforts currently ongoing elsevier inc rights reserved
novel mapping technique introductionidentification wavefront propagation pattern remains challenging ablation procedures sought test novel combination new mapping technology called ripple map high density mapping distinguish focal reentrant activation atrial fibrillation methods resultssubjects patients undergoing ablation persistent remained isolation pulmonary veins left atrium mapped high density mapping catheter later analysis ablation continued using conventional stepwise approach procedure electrograms high density mapping catheter analyzed using ripple map new feature carto type activation consecutive cycles determined high density mapping performed sites patients sites per patient wavefront propagation determined ripple map good agreement analysis manual annotation bipolar electrograms ripple map representation wavefront activation pattern could include local well far field activity allowed identify focal activation sites reentrant activation site radiofrequency delivery atrial regions activation sites identified focal ripple map resulted termination often regions without focal activation conclusionthis study demonstrated ripple map enabled quick identification wavefront activation pattern potentially helpful determining ablation targets persistent
novel pyrazolo pyridine derivatives designed synthesized evaluated orally active antagonists treatment overactive bladder matched molecular pair analysis mmpa allowed design new series pyrazolo pyridine derivatives structure activity relationships sar studies performed leading identification nanomolar level antagonist exhibited good pharmacological effect intraduodenal administration phenyltrinor prostaglandin induced bladder contraction model rats elsevier ltd rights reserved
novel znfeo bioi nanocomposites successfully synthesized simple economical method characterized ray diffraction xrd energy dispersive ray spectra eds scanning electron microscopy sem transmission electron microscopy tem vis diffuse reflectance spectra drs fourier transform infrared spectra photoluminescence znfeo particles determined deposited surface bioi successfully prepared znfeo bioi nanocomposites applied degrade rhodamine rhb methylene blue methylene orange visible light irradiation photocatalytic test suggested znfeo bioi nanocomposites exhibited higher activity degradation pollutants pure bioi znfeo visible light irradiation among prepared nanocomposites znfeo bioi displayed best photocatalytic activity degradation enhanced photocatalytic performance mainly ascribed separation efficiency carriers formation highly active species center dot surface znfeo bioi potential application treatment various pollutants wastewater utilizing solar energy effectively elsevier rights reserved
novelty seeking core personality trait primes susceptibility drug addiction striatal dopamine activity contributes cognitive flexibility important cognitive strategy inhibit impulsivity compulsive drug seeking behavior evidence supports association dopamine opioid dependent patients show higher levels repeated opioid exposure cause cognitive deficits including poor cognitive flexibility impaired impulse control however opioid dependent patients link striatal dopamine activity cognitive flexibility still unclear recruited opioid dependent individuals age sex matched healthy controls single photon emission computed tomography trodat ligand used measure striatal dopamine transporter dat availability trail making test tmt performed assess cognitive flexibility cloninger tridimensional personality questionnaire tpq used measure found opioid dependent patients striatal dat availability lower negatively associated tmt part part moreover inverted shape significantly matched scores function striatal dat availability maximum potential midrange dat availability extra sum squares test conducted indicating quadratic model fitted association dat better linear model brief opioid dependent patients striatal dat availability nonlinearly linked linearly linked cognitive flexibility role striatal dat transition controlled compulsive opioid use warrants research elsevier inc rights reserved
novice programmers often struggle many concepts underlying computer programming concept program variable named storage location centerpiece programming languages typically taught introductory computer science courses including java javascript python however date empirical studies suggest misinterpretation state program remains primary source errors novice programmers address challenge defining game based approach interactive program debugging emphasizing concept program state approach specifically chose metaphor popular space invaders videogame provide visual interpretation reinforces notion program state way likely attractive college students majoring computer science visualization technique resulting toolset intended steer students toward debugging mindset centered read write operations program variables discuss key aspects game based debugging approach also report preliminary results field studies actual college students used toolset debug simple programs injected faults
days exponential growth volume online users causes variety volumes data rapid development internet web technology big data big user adopting nosql large scale distributed computing cloud storage services brought great challenges traditional relational database nosql databases scalable accomplishing higher availability easily handle unstructured data know security main concern faced many big organizations document oriented nosql database mongodb many security issues vulnerabilities unencrypted data files weak authorization injection attack weak authentication client servers reduced efficient secure cryptographic techniques research paper discussed two public key cryptographic techniques named ecc rsa research paper proposed hybrid security architecture application server mongodb analyze encryption decryption time document data mongodb provide better security model order provide high level encryption mechanism good access control high authentication system better throughput system also compare key sizes better security mechanism new security protocol architecture designed fulfills basic parameter security areas architecture uses public private key cryptography provides security primitives confidentiality integrity authentication security primitives achieved help elliptical curve cryptography rsa dsa algorithm message digest
nowadays fully integrated enterprises replaced business networks participant provides others specialized services result service oriented manufacturing systems emerges systems complex hard engineer main source complexity number different technologies standards functions protocols execution environments must integrated order realize paper proposes framework associated engineering approach assisting system developers service oriented manufacturing systems approach combines multi agent system service oriented architectures development intelligent automation control execution manufacturing systems elsevier rights reserved
nowadays human exposed environment filling electromagnetic waves wide frequency range electromagnetic properties microwave absorbing materials plays important role performance civilian electromagnetic interference emi shielding low frequency range military stealth technology high frequency one electromagnetic properties include complex permittivity permeability combination determines electromagnetic wave absorption ability material complex permittivity permeability measured three different methods free space method coaxial waveguide method resonant cavity perturbation method first one requires large space expensive equipment suitable academic usage present study using coaxial waveguide resonant cavity perturbation methods electromagnetic characteristics iron based microwave absorbing materials obtained microwave absorption performance investigated addition comparison measurements two methods addressed
nowadays manufacturers forced shift traditional product manufacturing paradigm goods services continuum providing integrated combination products services adoption service based strategies natural consequence higher pressure companies facing global markets especially due presence competitors operate low wage region betting services specifically servitization manufacturing companies moving value chain order move competition costs sophistication innovation proliferation new emerging technologies paradigms together wider dissemination information technology significantly improve capability manufacturing companies infuse services products authors present knowledge based data driven platform support design development product extended services pess solutions
nowadays smartphone plays important role lives brings convenience efficiency overuse cause problems although great number studies demonstrated people affected substance abuse pathological gambling internet addiction disorder lower self control average scarcely study investigated decision making smartphone high users using behavioral paradigm present study employed intertemporal task smartphone addiction inventory spai barratt impulsiveness scale version bis explore decision control smartphone high users sample college students participants divided three groups according spai scores upper third higher middle third lower third lower scores defined high smartphone users medium users low users respectively compared percentage small immediate reward penalty choices different conditions three groups relative low users group high users medium users inclined request immediate monetary reward moreover two dimensions time money intertemporal choice high users medium users showed bias intertemporal choice task among time points value magnitude compared low users findings demonstrated smartphone overuse associated problematic decision making pattern similar seen persons affected variety addictions
nowadays firmware low cost microcontrollers mcus must implement cryptographic primitives order support practical applications effective protections implementations side channel attacks especially differential power analysis dpa attack still active topic embedded device security low cost mcus lack many features true random number generators typically used modern dpa countermeasures hand currently even low cost mcus contain several dozens kilobytes program flash memory always completely used target firmware paper propose new countermeasure dpa attack use randomly assigned general constant weight codes codes every intermediate value secure embedded device ideal hardware equal hamming weight data ensures balanced power consumption values device thus complicates dpa attack demonstrate method table based aes cipher propose several implementation enhancements reduce size tables suitable practical mcu implementations evaluate performance proposed method terms speed memory usage test possible side channel leakages system implemented arm cortex mcu elsevier rights reserved
nowadays information technologies play important role education education mobile applications considered support tool teaching learning process however relevant appropriate mobile applications always available teachers judge applications reviews anecdotes instead testing reasons lead needs benefits creating one mobile application teaching learning work present cloud based platform multi device educational software generation smartphones tablets web android based boxes smart devices called athenacloud important mention open cloud based platform allows teachers create multi device software using personal computer internet access goal platform provide software tool help educators upload electronic contents use existing contents open repository package desired setup file one supported devices operating systems
nowadays marine propulsion systems mainly based internal combustion diesel engines despite fact number lng carriers steam propulsion plants plants steam turbines used ship propulsion also electrical power generation main feed water pump drive marine turbo generators steam turbine main feed water pump drive investigated analyzed lng carrier steam propulsion plant measurements various operating parameters performed obtained data used energy exergy analysis measurements calculations performed ship acceleration analysis shows energy exergy efficiencies analyzed low power turbines vary significantly lower comparison high power steam turbines ambient temperature low impact exergy efficiency analyzed turbines change ambient temperature degrees causes less change exergy efficiency highest exergy efficiencies achieved lowest observed ambient temperature also highest efficiencies achieved maximum developed turbogenerator power highest efficiencies steam turbine main feed water pump drive achieved maximum turbine developed power replacing existing steam turbine main feed water pump drive electric motor would increase turbo generator energy exergy efficiencies least analyzed operating points elsevier ltd rights reserved
nowadays university college students digital natives prensky learning style learning culture quite different parents teachers digital immigrants prensky many previous research studies shown games powerful effective tool michael chen many educational domains military training lim jung yildirim marketing devitt management mayer health care ribaupierre lynch sauer foreign language learning johnson ludwig computer programming computer graphics mustaro job specific skills politics bogost etc however specific research discussing use serious games improve orthographic projection learning higher education setting technical graphics essential fundamental basis technologist designer education core technical graphics orthographic projection technical graphics communication skill critical significant asset students majoring engineering production design industrial design interior design architecture etc therefore main objective research develop serious game called itouying helping university students net generation tapscott games generation prensky master orthographic projection novel fashion itouying game composed nine sub units including orthographic projection concept orthographic projection knowledge quiz plane type judge stain plane front view selection top view selection right side view selection three view match proper model selection effectiveness itouying game towards learning examined surveys department mechanical engineering aeronautics astronautics national cheng kung university department industrial education national changhua university education evaluation results indicated university students favor using itouying game enhance orthographic projection learning effectiveness interactively also promote visualization skill model multi views moreover participants perceive stain plane unit unit satisfying unit proper model selection unit unit helpful unit learning orthographic projection furthermore completeness itoying game broaden scope survey including participants different departments different universities valuable feedback collected participants useful refine itouying game
nowadays power dominant factor constrains highly integrated hardware systems designs implied problems high power density causing chip overheating limited power source modern internet things devices commonly dealt use dynamic power management method enables use power reduction techniques clock gating power gating voltage frequency scaling since adoption power management quite difficult modern complex systems new approaches evolving intended simplify power constrained systems design also proposed approach utilizing system level design abstraction increased automation design process paper proposed hybrid verification approach described represents integral part suggested design methodology consists formal informal techniques enabling verification process begin early specification stage system development approach helps designer create correct consistent power management specification verifies whether specified power intent preserved design refinement continuous automated verification steps quickly find errors early design stages thus reduce amount design spins speeds overall development process
nowadays regional industry lacks human resources pressure created labor market high value economic projects tutors tend loaded teaching research administrative tasks students tend use electronically devices like laptops tablets mobile phones learning sessions context universities rely technologies like lmss learning management systems moocs massive open online courses glos generative learning objects evenaglos auto generative learning objects auto generative learning objects reusable pedagogical patterns instantiated generated content based random numbers fulfill learning objectives many online learning resources available containing interactive presentations gamifications several learning objectives learning resources hard reuse even harder modify adapt discipline needs needs access source code programming knowledge change test deploy etc paper focus computer science disciplines needed regional industry namely data structures algorithms show tutor build several auto generative learning objects order assess knowledge class students start design generic models assess generated content created help tool based meta programming afterwards deploy content webserver consumed students finally evaluate assessed results discuss approach student tutor perspective
nowadays incidence bone disorders steeply ascended expected double next decade especially due ageing worldwide population bone defects fractures lead reduced patient quality life autografts allografts xenografts used overcome different types bone injuries although limited availability immune rejection implant failure demand development new bone replacements moreover bacterial colonization bone substitutes main cause implant rejection vanquish drawbacks researchers tissue engineering area currently using computer aided design models medical data produce scaffolds rapid prototyping herein tricalcium phosphate tcp sodium alginate scaffolds produced using subsequently functionalized silver nanoparticles agnps two different incorporation methods obtained results revealed composite scaffolds produced direct incorporation agnps suitable used bone tissue regeneration since present appropriate mechanical properties biocompatibility bactericidal activity elsevier rights reserved
nowadays smart grid becoming smarter thanks integration different information communication technologies enhance reliability efficiency power grid however several issues met ensure high performance among issues cite problem electric vehicles evs integration avoid electricity intermittence due important load evs create another issue communication network security attempted malicious intruders order create damages make power grid instable context propose first level bayesian game theory model aims integrate optimally evs maintain equilibrium offer demand second level propose intrusion detection system ids protect attacks aim disturb state estimation numerical results prove efficiency robustness proposed models
nowadays technology evolves rapidly increases need qualified professionals field ict employment professionals projected grow worldwide till much faster average occupations main reason rapid growth large increase market demand computer software mobile applications regard nonprofit organizations established businesses looking alternative ways educate grow number people particular students involved learning computer programming hand students regardless age access internet via laptops tablets smartphones turns intuitive everyday learners gives access unlimited resources content information form web based platforms mobile learning applications social media online games others providing abundant diverse learning experience however matter fast technology evolves many alternative teaching techniques introduced constantly major challenge education still remains motivation context students driven learn playing online games interacting via social media expressing via digital resources rather struggling traditional educational methods relatively new gaining popularity form education use interactive online learning platforms merge possibility learning computer programming skills building digital games platforms designed using gamification approach provide vast entertaining methods based rich user experience interaction simulation purpose paper present innovative learning platforms learning computer programming explore features advantages drawbacks well investigate impact interactive learning experience create
related temporal data play important role medical context current relational temporal database tdb approaches limited since implicitly assume span time occurring time facts change world time changes recorded database exactly known explicitly provide extended relational algebra query related data propose approach widely adopting symbolic manipulation techniques overcomes limitations
nsaids constitute heterogeneous class pharmacological agents widely prescribed treatment inflammation pain edema well osteoarthritis rheumatoid arthritis musculoskeletal disorders class drugs proved efficacious account analgesic anti pyretic anti inflammatory activities gastrointestinal toxicity exists biggest problem associated chronic use many attempts made structurally modify conventional nsaids selective cox inhibitors based old still prevalent common belief selective inhibition cox would provide safer nsaids present work thus focused synthesis amide derivatives one conventional non selective nsaid meclofenamic acid utilizing one pot procedure involving selective agent bis oxo oxazolidinyl phosphonic chloride synthesized compounds tested vivo inflammatory activity using carrageenan rat paw edema assay subsequently docked cox pdb code cox better insights mechanism action amide derivative methoxybenzyl moiety tsn proved anti inflammatory potential better meclofenamic acid compound also docked highest dock score among synthesized compounds found hydrogen bonding arg tyr hydrophobic interactions val leu ser tyr trp met val ala ser methoxybenzyl amide derivative tsn followed benzyl amide derivative tsn meclofenamic acid identified potential anti inflammatory compounds vivo silico studies
numerical modelers often faced challenge numerically reproduce physical behavior soil geosynthetic interaction problems using assumed values missing soil interface model parameters paper examines two examples using finite difference method horizontal pullout geosynthetic geogrid reinforcement layer pullout box geosynthetic geotextile reinforced soil layer void also presents results parametric sensitivity analyses missing soil interface model parameter values identifies values give best agreement measured data paper demonstrates correct modeling geometrical nonlinearity key accurately predicting performance geosynthetic reinforced soil systems controlled tensioned membrane effect lessons learned study interest numerical modelers numerical model design geosynthetic reinforced soil systems
numerous breast cancer patients experience cognitive changes chemotherapy chemotherapy related cognitive impairment significantly affect quality life pilot study attempted determine effects compensatory cognitive training objective subjective cognitive functioning breast cancer patients receiving adjuvant chemotherapy fifty four patients assigned either compensatory cognitive training waitlist condition assessed baseline completion week intervention months intervention completion outcomes assessed using standardized neuropsychological tests functional assessment cancer therapy cognitive function fact cog version raw data converted scores based baseline scores repeated measures ancova adjusting age intelligence depression treatment used analysis effect sizes differences means calculated intervention group improved significantly time compared waitlist group objective cognitive function among ten individual neuropsychological measures immediate memory delayed memory verbal fluency category verbal fluency letter showed significant group time interaction subjective cognitive function scores waitlist group significantly decrease time perceived cognitive impairments contrast intervention group week compensatory cognitive training significantly improved objective subjective cognitive functioning breast cancer patients pilot study research using larger sample longer follow durations necessary
numerous epidemiological studies demonstrated close bidirectional association depression cardiovascular disorders cvd comorbidity places significant burden individuals healthcare system surprisingly last two decades preclinical research field depression cvd rapidly progressed multiple studies demonstrated aspects human depression cardiovascular comorbidity modeled rodents exposed chronic stress paradigms depressive like syndrome induced rodent models cvd research provided insights neural autonomic humoral immune circulatory mechanisms linking cooccurring mood cvd recent investigations started address gender individual differences vulnerability disorders begun explore efficacy novel pharmacological interventions treatment comorbid conditions review discusses relatively wellestablished findings latest discoveries rodent models depression cvd aim providing date reference may guide future studies relationship mood cardiovascular disturbances elsevier ltd rights reserved
numerous papers published advantage use ultrasonography magnetic resonance imaging mri detecting enthesitis diagnosing managing patients spondyloarthritis paper describes latest advances imaging enthesitis research agenda also defined answering unmet clinical needs
numerous simple impedance analysers based microcontroller dedicated impedance converter integrated circuits reported recently many applications sophisticated analogue circuitry appended enhance measurement possibilities circumvent limitations paper impedance analyser imp stm based solely general purpose operational instrumentation amplifiers presented uses internal dac adcs generate excitation measure response measured object also uses external analogue circuits condition excitation signal measure voltage current magnitudes phase shifts voltage current evaluated using three parameter sine fitting algorithm allowing fast low frequency impedance measurements calibration procedure completed device presented well tests accuracy device allowed measurements frequency range mhz khz omega omega impedance range accuracy imp stm also compared agilent precision impedance analyser middle impedance ranges omega omega discrepancies two less elsevier ltd rights reserved
numerous studies explored altered transcriptional landscape associated skin diseases understand nature disorders however data interpretation represents significant challenge due lack good maker sets many specialized cell types make tissue whose composition may fundamentally alter disease sought derive expression signatures define various cell types structures make human skin demonstrate used aid interpretation transcriptomic data derived organ two large normal skin transcriptomic datasets identified one rna seq microarray quality controlled subjected separately network based analyses identify clusters robustly expressed genes biological significance clusters assigned using combination bioinformatics analyses literature expert review cross comparison analyses gene signatures defined included expression signatures hair follicles glands sebaceous sweat apocrine keratinocytes melanocytes endothelia muscle adipocytes immune cells number pathway systems collectively named resource skinsig skinsig used analysis transcriptomic datasets skin conditions providing context interpretation data instance conventional analysis shown decrease keratinization fatty metabolism age accurately define changes due loss hair follicles sebaceous glands skinsig also highlighted representation various cell types skin diseases reflecting influx immune cells inflammatory disorders relative reduction cell types overall analyses demonstrate value new resource defining functional profile skin cell types appendages improving interpretation disease data authors journal pathology published john wiley sons ltd behalf pathological society great britain ireland
numerous studies reported association fine particulate matter human health often relationships influenced environmental factor varies spatially temporally knowledge studies canada considered energy generation fuel sales effects modifiers determining exposure disease specific risk factors space time crucial disease prevention control study evaluated association diabetes asthma high blood pressure hbp incidence canada explored impact energy generation fuel sales association changes fit age period cohort study design applied dispersed poisson regression model estimate risk conducted sensitivity analysis explore impact variation clean energy rates fuel sales outcomes changes study included health regions canada findings showed strong association diabetes asthma hbp incidence two year increase associated increased risk diabetes incidence asthma incidence hbp incidence sensitivity analysis findings suggest higher risks diabetes asthma hbp incidence low clean energy generation hand found lower risk considered high rate clean energy generation example considering diabetes incidence found risk health regions low rates clean electricity approximately higher risk health regions high rates clean electricity furthermore analysis suggested risk regions low fuel sales lower risk health regions low rates clean electricity study provides support creation effective environmental health public policies take account risk factors present canadians health regions elsevier rights reserved
numerous studies shown playing violent video games alone increases subsequent aggression however social game play becoming popular solo game play research suggests cooperative game play beneficial players current studies explore effects cooperative game play player subsequent aggressive behaviors toward video game partners experiment non video game partners experiment providing discussion possible theories applicable social video game play cooperative games resulted less aggression video game partners experiment non video game partners experiment competitive stand alone games interestingly cooperative game play game play produced similar levels aggression experiment whereas competitive solo game play produced similar levels aggression experiment findings consistent theory bounded generalized reciprocity playing violent games cooperatively offset aggression increasing effects violent video games
numerous studies shown viewing violence media influence individual subsequent aggression none examined effect viewing indirect aggression study examines immediate effect viewing indirect direct aggression subsequent indirect aggression among children ages years shown indirect direct aggression video subsequent indirect aggression measured negative evaluation confederate responses vignette participants viewing indirect direct aggression gave negative evaluation less money confederate participants viewing aggression participants viewing indirect aggression gave less money confederate viewing direct aggression participants viewing indirect aggression gave indirectly aggressive responses ambiguous situation participants viewing direct aggression gave directly aggressive responses study provides first evidence viewing indirect aggression media immediate impact subsequent aggression elsevier inc rights reserved
numerous vulnerabilities threat security mobile mip networks variety methods proposed protect mip networks attacks however methods heavy require significant time resources mip essential element within wireless mobile communication network provide fixed address among changes existing standard network mip network security essential one handover delay increased complicated authentication registration process essential goals mip provide seamless connection real time services security vulnerability became biggest problem real deployment solve problem paper proposes new lightweight authentication mechanism authentication authorization accounting aaa infrastructure mip networks original aaa authentication mechanism mobile node must wait nonce aaa server order generate session key used security associations home agent foreign agent paper introduces new mechanism enables unauthenticated initiate key generation process create secret key advance mechanism facilitates key distribution reducing cryptographic operations improvement handover time improvement copyright john wiley sons ltd
nurbs patches serious restriction constrained strict rectangular topology means request insert single new control point cause row control points appear across nurbs patch global refinement control investigate method hide unwanted control points user user interaction local rather global refinement method requires straightforward modification user interface data structures represent control mesh making simpler alternatives use hierarchical constructions results show method effective many cases limitations inserting single new control point certain cases still cause cascade new control points appear across nurbs patch authors published elsevier ltd open access article license http creativecommons org licenses
obesity common comorbidity schizophrenia studies addressed obesity chinese schizophrenia patients aims current study evaluate prevalence risk factors clinical correlates obesity chinese patients schizophrenia total patients recruited hospital beijing clinical anthropometric data together plasma glucose lipid parameters collected positive negative syndrome scale panss rated patients overall patients obese overweight obese patients significantly higher glucose levels triglyceride levels non obese patients females patients type diabetes mellitus increased risk obesity correlation analysis showed bmi associated sex education levels negative symptoms total panss score triglyceride levels type diabetes mellitus stepwise regression analysis showed sex type diabetes education level triglyceride amount smoking day significant predictors obesity study showed prevalence obesity chinese patients schizophrenia higher general population demographic clinical variables risk factors obesity schizophrenia
obesity growing public health problem united states particularly middle aged older adults although key factors leading population increase body weight still investigation evidence certain behavioral interventions mitigate negative cognitive brain neurocognitive health consequences obesity two primary behaviors often targeted weight loss caloric intake physical activity behaviors might independent well overlapping synergistic effects neurocognitive health date obesity often described independently behavioral interventions regards neurocognitive outcomes yet conceptual mechanistic overlap constructs review summarizes evidence linking obesity modifiable behaviors physical activity diet brain morphology gray white matter volume integrity brain function functional activation connectivity cognitive function across adult lifespan particular review evidence bearing following question associations obesity brain health aging adults modifiable behavioral interventions
obesity independent cardiovascular risk factor catalyst cardiovascular risk factors hypertension dyslipidemia type diabetes mellitus metabolic syndrome analyzed cardiovascular risk obese patients sleeve gastrectomy end studied changes body mass index bmi blood chemistry parameters characterize risk atherosclerosis instrumental parameters objective markers risk namely intima media thickness imt flow mediated dilation fmd latter reflecting endothelial function also considered purely cardiac parameters mitral annular plane systolic excursion mapse tricuspid annular plane systolic excursion tapse describe cardiac risk specifically ejection fraction alteration one parameters determines increase cardiovascular morbidity mortality results showed weight loss patients undergoing accompanied reduced bmi marked improvement blood chemistry confirming already shown many studies interesting finding effect instrumental markers atherosclerosis particular carotid imt significantly reduced fmd significantly improved mapse tapse also improved significantly follow assessments study suggests considered broader perspective weight loss treatment also improves obesity related morbidity mortality benefitting patient economic sense society whole
object coated plasma stimulated great interests many people stealth capability study conducting cylinder coated coaxial plasma much little works conducting cylinder coated eccentric plasma article model conducting cylinder coated eccentric unmagnetized plasma set scattering cross section object cylinder studied adopting superposition cylindrical wave functions coordinate transformation wave functions solutions maxwell equations boundary conditions cylindrical coordinates results show radar cross section conducting cylinder coated eccentric plasma every direction decrease obviously increase distance two eccentric axes almost impacted electronneutral collision frequency plasma backscattering cross section target reduce increase electron density comparing coaxial model backscattering cross section eccentric model smaller value wide frequency band significance target plasma stealth technology practice
object tracking well studied problem computer vision many practical applications problem difficulty depend upon several factors knowledge target object quantity type parameters tracked although success building trackers specific object classes human face mice etc tracking generic objects remained challenging issue object drastically change appearance deforming rotating plane illumination scene changes especially videos clear original form video requires enhancement quality improved proposed work different algorithms carried detect generic objects non rigid objects deformable objects occlusion cluttered environment images contain sort objects also images contains numerous objects unseen improve tracking efficiency objects non rigid changing nature also predicted perfect manner computational complexity reduced reliability accuracy efficiency improved
objective background aim characterize association functional single nucleotide polymorphisms serotonin receptor gene htra severity depression symptoms children autism spectrum disorder polymorphisms shown associated depression symptom severity response selective serotonin reuptake inhibitor drugs adults diagnosed depressive disorder methods parents children autism spectrum disorder rated children depressive symptoms using validated scale based criteria diagnostic statistical manual mental disorders edition compared severity depression symptoms across genotypes measured children genomic dna results children homozygous allele significantly severe depression symptoms genotypes effect size partial eta squared small eta somewhat larger controlled severity generalized anxiety disorder symptoms eta restricted analyses white participants results essentially entire sample eta significant association versus carriers severity depression conclusions findings suggest htra functional polymorphism studies associated differential htra mrna expression may modulate severity depression symptoms children autism spectrum disorder tentative hypothesis generating findings need replication larger independent samples
objective bone marrow stimulation surgeries frequent treatment cartilage lesions autologous chondrocyte implantation aci may performed failed microfracture surgery alterations subchondral bone intralesional osteophytes commonly seen previous microfracture removed aci reports potential recurrence purpose evaluate incidence intralesional osteophyte development cohorts existing intralesional osteophytes without intralesional osteophytes time aci study design identified patients lesions intralesional osteophytes among cohort aci patients osteophyte regrowth analyzed magnetic resonance imaging categorized small large less cartilage thickness twenty patients defects without intralesional osteophytes time aci acted control results osteophyte regrowth observed lesions small osteophytes large osteophytes subgroup analyses regrowth observed periosteal covered defects collagen membrane covered defects large osteophyte regrowth occurred less either group periosteal defects showed significantly higher incidence regrowth small osteophytes control group intralesional osteophytes developed lesions conclusions even though intralesional osteophytes may regrow removal aci small small osteophyte regrowth occurs almost twice periosteum covered aci large osteophytes occur patients intralesional osteophyte formation significantly different preexisting intralesional osteophytes control groups
objective pittsburgh compound pib positron emission tomography pet used visualize quantify amyloid deposition brain cortex pathological conditions alzheimer disease intense pib retention also observed white matter healthy individuals patients however clinical implications retention brain clarified investigated relationship extent white matter lesions wmls binding potential pib bpnd patients hypertensive small vessel disease examined relationship extent wmls bpnd wml normal appearing white matter nawm methods twenty one hypertensive vasculopathy patients without major cerebral arterial stenosis occlusion enrolled women years regions wml nawm extracted using magnetization prepared rapid gradient echo fluid attenuated inversion recovery magnetic resonance images volumes interest vois set cortex subcortex basal ganglia centrum semiovale bpnd cortex subcortex basal ganglia wml nawm estimated pib pet using logan graphical analysis cerebellar regions references relationships wml volume bpnd region examined linear regression analysis reults bpnd higher basal ganglia cortex subcortex regions wml volume significant inverse correlation bpnd slope intra comparison bpnd nawm significantly higher wml addition although correlations wml volume bpnd wml wml volume significantly correlated inversely bpnd nawm slope conclusion pib could marker cortical amyloid beta deposition also injury accompanying development wmls hypertensive small vessel disease
objective cerebral palsy common cause chronic disability restricts participation areas occupations children main aim rehabilitation enhancement clients participation occupations aim study overview factors influencing participations children iran materials methods systematic evidence based process duffy used data gathering electronic databases including google scholar iranian foreigner famous journals fields pediatrics used main key words search activity daily living adl instrumental activity daily living iadl play leisure work rest sleep social participation education papers study factors influencing participation iranian children totally articles found eligible iranian children study articles discarded repetitive duplicability articles articles removed well results studies iranian children participations life areas adl area participation lowest articles area field work play sleep rest occupational therapists focus life areas conclusion iran many researchers pay attention participation children many articles paid attention sensory motor cognitive components clients
objective cervical disc arthroplasty cda demonstrated safe effective anterior cervical discectomy fusion acdf management level degenerative disc disease ddd however lack data address fundamental discrepancy two surgeries cda acdf preservation versus elimination motion management cervical myelopathy associated congenital cervical stenosis ccs although younger patients tend benefit motion preservation uncertain ccs caused multilevel ddd treated safely cda methods consecutive patients underwent level anterior cervical discectomy retrospectively reviewed inclusion criteria age less years ccs pavlov ratio symptomatic myelopathy correlated ddd stenosis limited levels subaxial cervical spine exclusion criteria ossification posterior longitudinal ligament previous posterior decompression surgery laminoplasty laminectomy osteoporosis previous trauma rheumatic diseases might caused cervical myelopathy patients underwent level discectomy divided groups according strategies management preservation elimination motion hybrid cda group acdf group hybrid cda group underwent level cda plus level acdf whereas acdf group underwent level acdf clinical assessment measured visual analog scales vas neck arm pain japanese orthopaedic association joa scores nurick grades radiographic outcomes measured using dynamic radiographs evaluation range motion rom results thirty seven patients mean age years included final analysis male predominance series male patients mean follow duration years patients hybrid cda group acdf group groups demonstrated similar clinical improvement years follow patients level stenosis experienced significant improvement either type surgery hybrid cda acdf significant differences groups follow visits postoperatively preoperative rom operated subaxial levels similar groups degrees degrees postoperatively hybrid cda group significantly greater rom degrees degrees acdf group complications adverse events reoperations groups similarly low conclusions hybrid cda yielded similar clinical improvement level acdf patients myelopathy caused ccs relatively young group patients hybrid cda demonstrated significantly rom level acdf without adjacent segment disease asd years follow therefore hybrid cda appears acceptable option management ccs strategy motion preservation yielded similar improvements cervical myelopathy motion elimination acdf patients ccs theoretical benefit reducing asd required validation
objective gene environment interactions moderate aggressive behavior identified association maoa monoamine oxidase gene present study examined moderating effect maoa vntr variable number tandem repeats aggression behavior relating child abuse among chinese adolescents materials methods sample healthy chinese male adolescents completed child trauma questionnaire short form ctq youth self report child behavior checklist participants buccal cells sampled subjected dna analysis effects childhood abuse ctq scores maoa vntr high activity allele versus low activity allele interaction aggressive behaviors analyzed linear regression results child maltreatment found significant independent factor manifestation aggressive behavior whereas maoa activity significant interaction maoa vntr childhood maltreatment exhibition aggressive behaviors context physical emotional abuse boys maoa group showed greater tendency toward aggression maoa group conclusion aggressive behavior arising childhood maltreatment moderated maoa vntr may differentially sensitive subtype childhood maltreatment experienced among chinese adolescents copyright wolters kluwer health inc rights reserved
objective macrovascular diseases urgency incontinence common among japanese patients type diabetes mellitus however little evidence exists regarding association stroke urgency incontinence among patients type diabetes mellitus examined associations macrovascular complications urgency incontinence among japanese patients type diabetes mellitus methods study subjects japanese patients type diabetes mellitus urgency incontinence defined present subject answered week question within one week often leak urine defer sudden desire urinate adjusted analyses sex age body mass index duration type diabetes current smoking current drinking hypertension dyslipidemia glycated hemoglobin diabetic nephropathy diabetic retinopathy diabetic peripheral neuropathy results prevalence urgency incontinence stroke independently positively associated urgency incontinence adjusted odds ratio confidence interval associations ischemic heart disease peripheral artery disease prevalence urgency incontinence significant conclusion japanese patients type diabetes mellitus stroke ischemic heart diseases peripheral artery disease independently positively associated urgency incontinence
objective patients commonly use internet obtain health related information purpose study investigate quality accuracy readability online patient resources management articular cartilage defects design three search terms cartilage defect cartilage damage cartilage injury entered internet search engines google bing yahoo first websites search collected reviewed quality accuracy online information independently evaluated reviewers using predetermined scoring criteria readability evaluated using flesch kincaid grade score results fifty three unique websites evaluated quality ratings significantly higher websites score compared score websites differentiated focal cartilage defects diffuse osteoarthritis elicited using search term cartilage defect average accuracy websites high maximum average grade level several grades higher recommended level readable patient education material eighth grade level conclusions quality readability online patient resources articular cartilage defects favor higher level education additionally majority websites distinguish focal chondral defects diffuse osteoarthritis fail provide appropriate patient education guidance available treatment clinicians help guide patients toward high quality accurate readable online patient education material
objective suitable magnetic resonance imaging mri techniques conventional new devices help physicians diagnosis follow multiple sclerosis patients aim present research compare effectiveness fluid attenuation inversion recovery flair sequence conventional mri diffuse weighted imaging dwi sequence new technique detection brain plaques materials methods analytic cross sectional study sample size assessed people detect significant difference two sequences level dwi flair sequences without contrast brain mri consecutive patients referred mri center shahid sadoughi hospital yazd iran january may evaluated results thirty two females males mean age range evaluated finally plaques including twi flair dwi twi detected flair sequence efficient dwi detection brain plaques oval round amorphous plaque shapes frontal occipital lobes periventricular intracapsular corpus callosum centrum semiovale subcortical basal ganglia plaques diameter detected plaques dwi sequence smaller flair conclusion old lesion detected conventional mri new techniques might useful early inflammatory phase assessment experimental treatments
objective aim present study evaluate presence degree spontaneous echo contrast sec left atrium left atrial appendage laa contractility cardioversion patients recent onset atrial fibrillation methods study included patients divided two groups group comprising clinically stable patients admitted emergency department less equal duration underwent transoesophageal echocardiography tee guided control group group comprising patients admitted cardiological department elective tee guided greater patients underwent repeat tee within successful results patients recent onset group showed thrombogenic milieu baseline without evidence atrial stunning successful sec mean grade grading versus laa flow velocity versus group patients showed significantly higher degree sec compared group significantly lower laa flow velocities significant worsening successful sec degree laa flow velocity conclusion absence thrombogenic milieu left atrial stunning patients recent onset favours early without anticoagulation least patients low thromboembolic risk profile patients could discharged earlier urgent care copyright wolters kluwer health inc rights reserved
objective risk leg amputation among patients diabetes declined past decade use preventative measuressuch hemoglobin monitoringhas increased however relationship hemoglobin testing amputation risk remains unclear methods examined annual rates hemoglobin testing major leg amputation among medicare patients diabetes across hospital referral regions created linear regression models study associations hemoglobin testing lower extremity amputation results proportion patients received hemoglobin testing increased rate lower extremity amputation decreased beneficiaries regional hemoglobin testing weakly correlated crude amputation rate years weakened adjustment age sex disability status multivariable model amputation rates hemoglobin testing significant predictor conclusion lower extremity amputation among patients diabetes nearly halved past decade weakly correlated hemoglobin testing throughout study period better metrics needed understand relationship preventative care amputation
objective study aimed evaluate efficacy functional independence measure assess preoperative frailty elderly patients undergoing surgical aortic valve replacement methods eighty five patients years survived elective isolated aortic valve replacement january october included mean age operation years old males females patients divided two groups according status discharge impossible discharge home hospitalization days compromised group unaffected unaffected group preoperative frailty evaluated functional independence measure comprises items divided six domains self care sphincter control mobility locomotion communication social cognition results preoperative total functional independence measure score significantly lower compromised group unaffected group preoperative motor functional independence measure score significantly lower compromised group unaffected group duration postoperative intubation intensive care unit stay postoperative hospitalization significantly longer compromised group unaffected group days days respectively conclusions preoperative functional independence measure effective assessing preoperative frailty elderly patients undergoing aortic valve replacement terms predicting operative morbidity
objective analyse clinical serological sonographic differences rheumatoid arthritis polyarticular psoriatic arthritis psa patients anti tnf therapy clinical remission methods angiogenic proinflammatory cytokine serum levels determined multiplex elisa patients psa clinical remission das esr healthy controls ultrasound scans made wrists hands results psa patients remission active patients healthy controls included psa patients significantly lower disease activity according das esr according das crp lower serum levels proinflammatory angiogenic cytokines patients remission psa patients cytokine levels similar healthy controls patients remission similar levels active patients globally patients remission signal plus psa meeting criteria ultrasound defined active synovitis udas patients udas significantly higher levels pigf sdfi psa patients tapered doses anti tnf frequently monotherapy compared patients respectively conclusion polyarticular psa patients remission lower levels local synovitis systemic inflammation patients remission even though significantly higher percentage psa patients tapered doses anti tnf mainly monotherapy
objective characterise associations fatigue variables within multidimensional health assessment questionnaire mdhaq routine care patients different rheumatic diagnoses methods patients complete mdhaq includes fatigue visual analogue scale vas routine assessment patient index data rapid composite function pain patient global physicians complete rheumetric checklist includes vas overall global status docgl inflammation damage distress median score fatigue mdhaq rheumetric scores compared diagnosis groups rheumatoid arthritis osteoarthritis systemic lupus erythematosus sle fibromyalgia using kruskall wallis test associations fatigue variables analysed using spearman correlations multivariate regressions results patients included sle median fatigue significantly higher sle fatigue correlated significantly mdhaq scores higher levels sle versus fatigue correlated significantly docgl sle multivariate analyses fatigue scores explained independently higher pain symptom number lower age higher symptom number higher pain sle none variables conclusion fatigue common rheumatic diseases strongly associated higher pain number symptoms mdhaq provides useful tool assess fatigue clinical settings
objective compare parent reported feeding difficulties nutritional adequacy children autism spectrum disorders asd age socio economically matched group typically developing children methods scores children eating behavior inventory cebi three day food records anthropometric measures adequacy micro macro nutrients compared children diagnosed asd typically developing children enrolled department pediatrics tertiary care teaching hospital north india results majority parents asd children reported concern regarding feeding behavior compared parents typically developing children compared controls asd children significantly higher cebi scores feeding problems relative controls asd children consumed fewer number food items particularly fruits vegetables proteins significantly lower daily intake potassium copper folate although children autism differ significantly controls intake calories height weight body mass index significantly greater proportion asd children failed meet estimated average requirement thiamine vitamin copper conclusions findings underscore need comprehensive assessment empirically supported interventions eating problems dietary deficiencies found asd children
objective describe communication techniques used clients veterinarians companion animal visits australia design cross sectional descriptive study methods total veterinary consultations audiotaped analysed roter interaction analysis system rias clients completed appointment level measures including satisfaction perceptions relational communication results participants veterinarians clients statements intended reassure clients expressed frequently consultations appointments empathy statements expressed towards either client patient appointments veterinarians used open ended questions overall client satisfaction high veterinarians expressions empathy directed client resulted higher levels client satisfaction clients perceptions relational communication related several veterinarian client nonverbal scales conclusions focus developing evidence based clinical communication skills expected enhance veterinarian client patient relationship associated clinical outcomes particular recommendations include development broader emotion handling repertoire increased emphasis use open ended enquiry including assessment client perspective well attention aspects nonverbal communication study provides preliminary evidence importance verbal expressions empathy companion animal consultation
objective examine relationship public health system network density organizational centrality public health systems public health governance community size health status three public health domains data sources study setting fall winter primary data collected organization composition eight rural public health systems study design multivariate analysis network graphical tools used case comparative design examine public health system network density organizational centrality domains adolescent health senior health preparedness differences associated public health governance centralized decentralized urbanization micropolitan noncore health status public health domain collaboration area described data collection extraction methods site visit interviews key informants local organizations web based survey administered local stakeholders principal findings governance urbanization public health domain health status associated public health system network structures centrality local health departments lhds varies across public health domains urbanization collaboration greater assessment assurance advocacy seeking funding conclusions public health system organization causally related improved health status studying individual system components lhds prove insufficient studying impact public health systems
objective investigate changes nucleus pulposus cell expression secretion interleukin tumour necrosis factor tnf following stimulation low frequency pulsed electromagnetic field pemf methods primary rat nucleus pulposus cells isolated cultured invitro followed stimulation pemfs frequency different intensities ranging cells observed morphological changes proliferation rates measured cell viability counts expression tnf within nucleus pulposus cells measured using western blotting levels tnf secreted culture media measured using enzyme linked immunosorbent assay results stimulation nucleus pulposus cells pemfs appear affect cell morphology nucleus pulposus cell tnf expression levels pemfs significantly affect cell proliferation however levels tnf secreted culture media found significantly reduced intensity dependent manner conclusion low frequency pemf stimulation may inhibit secretion tnf cultured nucleus pulposus cells
objective measure impact pediatricians perceived self efficacy confidence current practices attitudes regarding four violence prevention topics gun storage gun removal limiting exposure media violence discipline techniques health supervision children ages methods random sample survey american academy pediatrics fellows response rate providing health supervision children ages participants surveyed issues regarding current counseling practices year olds amount time spent addressing confidence addressing perceived self efficacy changing patients behaviors multivariate analyses explored relationships pediatricians perceived self efficacy confidence versus counseling frequency results topics routinely discussed health supervision pediatricians reported spending little time addressing topics although pediatricians felt confident discussing effective changing behaviors regarding limiting exposure media violence discipline techniques less safe gun storage gun removal perceived self efficacy mediating factor self reported counseling frequencies topics conclusions pediatricians reported spending insufficient time counseling confidence perceived self efficacy levels varied topic topics pediatricians felt confident discussing effective changing behaviors since pediatricians self efficacy related counseling practices boosting self efficacy could ultimately improve counseling frequencies research needed identify methods build providers perceived self efficacy regarding areas
objective aim study develop prototype innovative burr hole mounted device stabilizing endoscopes intracranial surgery objective easily maneuverable device freeing one hand without compromising flexibility safety could avoid need second surgeon bulky holder thus improving coordination methods initial concept arose observation intraventricular endoscopy often performed surgeons navigating endoscope inserting handling instruments working channel specification analysis performed desired properties specified literature review well informal interviews surgeons engineers tools used design included blueprints dimensional computer aided design cooperating engineers final prototype printed toruses produced molding results prototype named buesta burr hole endoscope stabililizer produced consists half hollow sphere parts interchangeable toruses following features easy produce inexpensive prolonging surgical time semirigid variable fixation easy fix release safe bulky articulated arms mimicking basic concepts second hand fixation index finger thumb fixation hand resting stabilizing skull conclusions work represents feasibility study including specification analysis design prototyping novel burr hole endoscope stabilizing device device offers variable support endoscope complete free hand semirigid rigid thus freeing one hand often used stabilize endoscope potentially help achieve solo surgery
objective brain computer interfaces bci based event related potentials erp incorporate decoder classify recorded brain signals subsequently select control signal drives computer application standard supervised bci decoders require tedious calibration procedure prior every session several unsupervised classification methods proposed tune decoder actual use omit calibration methods strengths weaknesses aim improve overall accuracy erp based bcis without calibration approach consider two approaches unsupervised classification erp signals learning label proportions llp recently shown guaranteed converge supervised decoder enough data available contrast formerly proposed expectation maximization based decoding erp bci guarantee however decoder high variance due random initialization parameters obtains higher accuracy faster llp initialization good introduce method optimally combine two unsupervised decoding methods letting one method strengths compensate weaknesses vice versa new method compared aforementioned methods resimulation experiment visual speller main results analysis experimental results shows new method exceeds performance previous unsupervised classification approaches terms erp classification accuracy symbol selection accuracy spelling experiment furthermore method shows less dependency random initialization model parameters consequently reliable significance improving accuracy subsequent reliability calibrationless bcis makes systems appealing frequent use
objective conventional multi channel scalp electroencephalography eeg allows identification attended speaker concurrent listening cocktail party scenarios implies eeg might provide valuable information complement hearing aids form eeg install level neuro feedback approach investigate whether listener attentional focus detected single channel hearing aid compatible eeg configurations recorded eeg three electrodes inside ear canal ear eeg additionally electrodes scalp two different concurrent listening tasks participants fitted individualized ear eeg pieces either asked attend one two dichotically presented concurrent tone streams one two diotically presented concurrent audiobooks forward encoding model trained predict eeg response single eeg channels main results individual participants attentional focus could detected single channel eeg response recorded short distance configurations consisting single ear eeg electrode adjacent scalp eeg electrode differences neural responses attended ignored stimuli consistent morphology polarity latency components across subjects significance sum findings show eeg response single channel hearing aid compatible configuration provides valuable information identify listener focus attention
objective physicians ethical legal mandate identify abused children may protected harm simultaneously required think broadly objectively differential diagnoses medical literature replete examples medical diseases mimic abuse potentially leading misdiagnoses subsequent harm children families conclusion review highlights common uncommon diseases mimic physical sexual abuse children
objective research concerning spinal mobility axial spondyloarthritis axspa focused ankylosing spondylitis data clinical diagnosis undifferentiated spondyloarthritis uspa limited objective study differences spinal mobility axspa subgroups uspa including gender differences methods total patients axspa rheumatology clinic included study earliest recorded spinal mobility measures cervical rotation flexion extension lateral flexion tragus wall distance vital capacity chest expansion thoracic flexion thoracolumbar flexion lateral spinal flexion lumbar flexion intermalleolar distance obtained specialized physiotherapists differences subgroups analysed using analysis covariance controlled gender disease duration results uspa group mean standard deviation age years disease duration years men group mean age years disease duration years men spinal mobility less restricted uspa versus patients median interquartile range tragus wall distance versus thoracolumbar flexion versus lateral spinal flexion versus lumbar flexion versus intermalleolar distance versus differences subgroups cervical mobility vital capacity chest expansion thoracic flexion gender differences besides anthropometric measures conclusion patients uspa similar cervical chest mobility thoracic lumbar mobility severely restricted gender differences either subgroup studies understand full impact uspa spinal mobility needed copyright john wiley sons ltd
objective aim study evaluate effects resistance exercise bone markers patients material methods twenty six patients undergoing hemodialysis assigned either exercise group control group performed approximately six months intradiatytic resistance exercise program using elastic bands leggings lower limbs monitored thrice weekly sessions received standard care plasma bone markers osteoprotegerin opg osteocalcin osteopontin opn intact parathyroid hormone ipth measured luminex results opg levels increased significantly resistance training whereas opn ipth change conclusion summary resistance exercise may contributed increase opg plasma levels probably prevention bone loss among patients participated exercise program elsevier masson sas rights reserved
objective majority literature regarding sports injuries concentrated specific characteristics related sports injuries injuries sport activities strove establish whether success rehabilitation process predicted based numerous psychosocial variables methods sample comprised competing athletes underwent operative knee surgery rehabilitation process athletes lasted one months athletes obtained serious injuries standards national athletic injury reporting system following variables measured coping pain sip rehabilitation behaviours sirbs motivation rehabilitation anxiety stai social support questionnaire measures functioning knee ikdc taken indicator rehabilitation success participants tested prior following process rehabilitation results results showed success psychological rehabilitation could predicted changes certain psychosocial variables decrease anxiety increase susceptibility self efficacy catastrophizing rehabilitation athletes able reach criteria successful physical psychological rehabilitation conclusions conclude since selected psychological variables found high loading psychological rehabilitation makes sense control variables
objective objective present study evaluate arthritis like findings mri studies forefeet healthy volunteers versus patients symptomatic rheumatoid arthritis psoriatic arthritis psa materials methods two observers analyzed images forefeet healthy volunteers patients symptomatic patients symptomatic psa identify mri patterns psa bone marrow edema bme erosions tenosynovitis joint effusion periarticular soft tissue edema bony proliferations basis outcome measures rheumatoid arthritis clinical trial mri scoring system psa mri scoring system mann whitney test bonferroni correction used statistical analysis results reader found bme healthy volunteers whereas reader found bme volunteers tenosynovitis observed reader three healthy volunteers joint effusion found reader seven healthy volunteers reader three volunteers mean intensity grades findings low range erosions soft tissue edema bony proliferations found forefeet healthy volunteers reader reader observed arthritis like features images patients percentages patients mri features identified reader reader respectively follows bme erosions tenosynovitis effusion soft tissue edema bony proliferations percentages patients psa found arthritis like findings images determined reader reader respectively follows bme erosions tenosynovitis effusion soft tissue edema bony proliferations observed reader patients psa mean minimum intensity grade tenosynovitis patients observed reader whereas maximum intensity grade erosions patients observed reader tenosynovitis soft tissue edema observed frequently patients psa patients conclusion forefoot healthy volunteers mild bme common finding tenosynovitis joint effusion occasional findings frequency intensity arthritis like findings mri similar patients psa exception tenosynovitis soft tissue edema frequently observed patients psa patients
objective objective study evaluate effect intervention advance provision emergency contraceptive pills ecp condoms extended information targeted group teenage girls compared control group months intervention material methods randomized controlled trial among girls years old requesting emergency contraception youth clinic sweden carried data collected questionnaire initial visit structured telephone interviews months enrolment differences intervention group control group regarding ecp use time interval unprotected intercourse ecp intake contraceptive use sexual risk taking analysed results one year intervention girls could reached follow girls intervention group reported shorter time interval mean hours unprotected intercourse ecp intake compared control group mean hours without evidence decreased use contraceptives increased sexual risk taking conclusion even months following intervention advance provision ecp one single occasion specific target group adolescent girls shortens time interval unprotected intercourse pill intake without jeopardizing contraceptive use increasing sexual risk taking considering clinical relevance results suggest advance provision ecp could implemented routine preventive measure target group
objective purpose study evaluate performance natural language processing nlp system classifying database free text knee mri reports two separate academic radiology practices materials methods nlp system uses terms patterns manually classified narrative knee mri reports constructed nlp system trained tested expert classified knee mri reports two major health care organizations radiology reports modeled training set vectors support vector machine framework used train classifier separate test set organization used evaluate performance system evaluated performance system within across organizations standard evaluation metrics accuracy precision recall score weighted average precision recall respective cis used measure efficacy classification system results accuracy radiology reports belonged model clinically significant concept classes training data institution good yielding score greater performance classifier cross institutional application without institution specific training data yielded scores two organizations studied conclusion results show excellent accuracy nlp machine learning classifier classifying free text knee mri reports supporting institution independent reproducibility knee mri report classification furthermore machine learning classifier performed well free text knee mri reports another institution data support feasibility multiinstitutional classification radiologic imaging text reports single machine learning classifier without requiring institution specific training data
objective utility synovial biopsy increasing understanding pathogenesis inflammatory arthropathies well evaluating treatments well established ultrasound allows synovial assessment therefore assists biopsying synovial tissue safe well tolerated manner study objectives determine rate success retrieving synovial tissue using guidance describe indications guided synovial biopsies clinical setting determine frequently synovial biopsy lead clear diagnosis assess quality synovial tissue obtained using technique methods synovial biopsies small large joints performed guidance february december using semiautomatic core biopsy needle biopsy procedure considered successful synovial tissue found histological examination results seventy four patients undifferentiated arthritis underwent synovial biopsies success rate retrieving synovial tissue one patient taking acetyl salicylic acid time biopsy presented hemarthrosis procedure resolved following simple arthrocentesis definitive diagnosis achieved patients synovial tissue sampled successfully conclusion guided synovial biopsies clinical practice performed safely patients undifferentiated arthritis heterogeneous presentations rate success acquiring synovial tissue high procedure usually retrieves quality tissue leads definite diagnosis significant minority patients
objective study aimed assess infrared thermography irt ultrasonography detecting wrist arthritis juvenile idiopathic arthritis jia patients although irt could help detecting joint inflammation irt studies jia patients wrist arthritis still limited currently validated criteria exist detecting arthritis useful parameters gray scale ultrasound gsus power doppler ultrasound pdus remain unclear approach forty six jia patients included study detecting wrist arthritis varying degrees using irt compared physical examination main results sixteen patients previous wrist arthritis currently inactive still wrist arthritis median ages iqr years respectively fifteen healthy participants included median age iqr years using irt mean temperature mean maximum temperature max skin surface region interest roi arthritis group higher inactive group healthy controls degrees max degrees respectively gsus pdus useful detecting arthritis providing high sensitivity specificity significance study demonstrated irt applicable tools detecting wrist arthritis
objective determine feasibility tnf inhibitor tnfi dose reduction severe psa patients methods retrospective study real world setting criteria dose reduction tnfi included basdai das esr psa escalated standard treatment dose results twenty six per cent psa patients fulfilled criteria underwent tnfi dose reduction fifty eight per cent psa patients maintained tnfi dose reduction mean years reinstating standard dose tnfi recaptured low disease activity patients failed dose reduction within weeks statistically significant difference mean basdai compared maintaining tnfi dose reduction weeks mean basdai respectively however psa failed dose reduction higher disease activity compared patients maintained tnfi dose reduction weeks mean das esr respectively psa lower das esr prior dose reduction tnfi associated successful dose reduction conclusions real world setting individuals severe psa achieve low disease activity successfully reduce dose tnfi therapy third mean year
objective determine effect prior tumor necrosis factor inhibitor tnfi therapy secukinumab efficacy psoriatic arthritis psa methods patients randomized secukinumab placebo results american college rheumatology responses week secukinumab placebo tnfi naive tnfi exposed patients respectively week responses secukinumab tnfi naive tnfi exposed patients respectively conclusion secukinumab efficacious tnfi naive tnfi exposed patients psa greatest improvements tnfi naive patients
objective develop genotype based ankylosing spondylitis risk prediction model sensitive specific hla typing methods develop genetic risk scoring grs model individuals cases controls examined copy number variants cnv single nucleotide polymorphisms snp hla marker taqman assays grs model developed using logistic regression validated larger independent set cases controls results logistic regression built grs model consisting genetic components hla cnv snp significant associations genetic factors model replicated independent validation set discriminative ability grs model measured area curve excellent tion set model construction set validae grs model showed higher specificity accuracy hla model sensitivity set categorized individuals quartiles based grs scores groups low intermediate intermediate high risk showed increasing trend grs scores highest risk group showed higher risk lowest risk group conclusion grs could used identify individuals high risk major symptoms appear may improve prognosis early treatment
objective examine relationship frailty pain particularly analyze whether pain predicts physical psychological social frailty controlling effects life course determinants comorbidity design cross sectional methods nonprobabilistic sample community dwelling elderly recruited frailty determinants frailty assessed tilburg frailty indicator pain measured pain impact questionnaire hierarchical logistic regression analyses conducted results study participants aged years women pain frailty higher women physical frailty higher aged similar years controlling effects determinants comorbidity pain predicted variance frailty variance physical frailty variance psychological frailty prediction social frailty nonsignificant overall greater pain impact score associated presence frailty odds ratio conclusion frailty independently predicted pain emphasizing importance treatment potentially contributing prevention vulnerability dependency mortality nonetheless longitudinal studies required better understand possible association pain frailty
objective study real life setting construct validity reliability interpretability item psoriatic arthritis impact disease psaid questionnaire patients psoriatic arthritis psa methods consecutive patients psa men women mean age yrs receiving biologic treatment psaid patient reported outcomes pro collected dermatology life quality index patient underwent articular skin assessment results construct validity factor analysis revealed factor result defined psaid symptom score psaid skin score determining convergent validity significant correlations found psaid clinical disease activity index psoriatic arthritis cdapsa rho multivariable analysis showed psaid determined articular disease activity cdapsa severity psoriasis pso physician global assessment presence coexisting fibromyalgia reliability cronbach alpha coefficient total psaid interpretability applying cdapsa categorization disease activity states psaid cutoff values resulted remission low disease activity lda lda moderate disease activity mda mda high disease activity conclusion psaid excellent pro evaluate effect psa carefully handled patients coexisting
objective evaluated whether scalp psoriasis pso associated psoriatic arthritis psa severity treatment response etanercept methods patients moderate severe pso active psa received etanercept weekly weeks patients stratified according whether scalp pso present baseline demographics disease characteristics compared baseline weeks treatment etanercept results scalp pso present patients significantly younger higher proportion male versus without scalp pso baseline patient global assessment psoriasis score significantly higher patients scalp pso versus without tender joint count significandy higher patients without scalp pso higher proportion patients without versus scalp pso achieved enthesitis week dactylitis week patients scalp pso showed significantly greater improvements fatigue joint pain weeks greater proportion achieved score health assessment questionnaire week conclusion scalp pso clearly associated psa severity affect treatment response patients without scalp pso exhibited greater improvements objective joint outcomes whereas patients scalp pso experienced better outcomes patient reported outcomes
objective residence zhongshan station degrees degrees year exposes winter members marked changes light dark cycle ranging constant daylight polar days constant darkness polar nights addition geographic social isolation extreme photoperiodic environment may increase risk sleep disturbances circadian desynchrony aim study investigate circadian rhythm sleep phase chinese winter expeditioners zhongshan station methods study conducted healthy male participants departure shanghai residence zhongshan station year winter mid winter end winter sequential urine samples hours obtained sulphatoxymelatonin urine assessed circadian rhythm analyzed cosine curve fitting method participants sleep parameters obtained wrist actigraphy sleep logs morningness eveningness questionnaire seasonal pattern assessment questionnaire completed results acrophase sulphatoxymelatonin rhythm sleep onset sleep offset mid sleep time delayed significantly antarctica relative departure values subjects greater eveningness preference mid winter antarctica global seasonality score prevalence subsyndromal seasonal affective disorder increased winter conclusions results indicate polar nights chinese expeditioners experienced following problems delayed circadian rhythm sleep phase later chronotype incidence subsyndromal seasonal affective disorder appropriate combination artificial bright light dark winter months strict social schedule recommended winter station antarctica
objective rock climbing widely performed sport prospective single institution study evaluated demographics climbing related injuries improve comprehension current injury characteristics methods year period patients total independent climbing injuries prospectively evaluated using standard questionnaire examination protocol results injuries upper extremities lower seventeen injuries union international des associations alpinisme uiaa grade injuries grade grade higher uiaa graded injuries occurred overall acute injuries seen clinic seen emergency department overstrain injuries seen clinic finger injuries accounted injuries shoulder second frequent location pulley injuries frequent finger injuries injured young climbers age years epiphyseal fracture epiphyseal fractures mean age years range years male climbers significantly older climbing years climbing higher climbing level older experienced climbers significantly overstrain injuries acute injuries conclusions comparing study previous study notable differences although pulley injuries still common climbing injury pulley injuries shoulder injuries becoming common epiphyseal fractures among young climbers important understand current patterns climbing injuries health providers target interventions appropriately
objective describe development impact migraine partners adolescent children impac scale background although existing data clinical experience suggest impact migraine pervasive extends beyond individual migraine validated tools exist assessing impact migraine family methods chronic migraine epidemiology outcomes cameo study longitudinal study people migraine united states family burden module fbm cameo study contained item pool questions derived literature review clinician input patient focus groups pertaining following concepts impact migraine family interpersonal relationships activities well finances health related quality life respondents migraine probands categorized groups based household composition migraine probands partners spouses children migraine probands partners spouses migraine probands child ren migraine probands without partner spouse child ren impac scale developed steps exploratory factor analysis item reduction bifactor analysis confirmatory factor analysis scoring reliability construct validity analyses results analysis data respondents fbm meeting criteria migraine yielded item impac scale items applying groups items applying groups partners additional items groups children item responses summed converted scoring system assessing mild mean impac scale grade moderate mean grade severe mean grade family impact test information curves relating impac scale household type indicated adequate reliability across large range family burden severity similar similar mean impac scores showed moderate large correlations validated tools range providing support construct validity conclusions developed questionnaire assess family burden attributed migraine brief robust psychometrically sound simple scoring algorithm applied various household compositions questionnaire may valuable research settings provide quantifiable data impact migraine family dynamics clinical settings facilitate conversations family burden target motivation better treatment
objective determine policy recommendations american academy pediatrics aap regarding television viewing heeded inpatient pediatric setting setting inner city academic medical center participants consecutive sample pediatric inpatients methods investigator visited pediatric inpatient rooms observations made patient present room alert awake main outcome measure exposure inappropriate programming accordance aap guidelines used established television rating system code programs appropriate versus inappropriate children classified rated shows centered adult themes informational educational nonviolent inappropriate tested parental demographics age child time day presence adult room possible predictors results ninety one percent patients television turned tuned inappropriate programming exposure inappropriate programming differ parental ethnicity language education exposure highest infants toddlers compared children adolescents vary time day exposure higher adult present room effect pronounced adolescents conclusions despite aap recommendations hospitalized children exposed inappropriate programming especially parents present room hospital stays may unique opportunity educate parents aap recommendations television viewing children
objective hypothesiseosinophilic otitis media eom variant chronic otitis media characterized development thick mucoid middle ear effusion adult onset bronchial asthma sinonasal polyposis aspirin sensitivity eom typically refractory corticosteroid therapy surgical intervention pegylated interferon peg ifn effectively treated hypereosinophilic syndrome clinical trials however efficacy medication eom treatment remains undefined study designretrospective case series tertiary academic center methodsa retrospective chart review performed eom patients total patients met clinical criteria eom according established diagnostic guidelines outcomes patients severe refractory eom initiated peg ifn therapy reported resultseight patients treated pegylated interferon refractory eom half patients significant side effects interferon treatment three able continue reduced dosage without side effect reoccurrence one patient stopped medication permanently four eight patients complete clinical response total resolution otorrhea normalization middle ear mucosa able discontinue corticosteroid treatment two patients attempted stop peg ifn therapy prolonged symptom remission recurrent otorrhea patients symptom resolution peg ifn reinitiation conclusionsthese data demonstrate pegylated interferon therapy may benefit patients severe refractory eom larger studies long term follow required validate early promising results level evidence laryngoscope
objective classic physiologic response systemic hypoxia increase red blood cell production hypoxia inducible factors hifs orchestrate oxygen sensing machinery hypoxic cell metabolism recent works suggest mutation hif oxygen sensing pathway plays key role pathogenesis erythrocytosis present study probable role polymorphic hif alpha variants known enhance transcriptional activity evaluated etiology polycythemia methods total subjects normal levels hemoglobin hgb high levels hgb polycythemia vera recruited study genomic dna extracted peripheral blood lymphocytes subjects polymerase chain reaction restriction fragment length polymorphism pcr rflp method performed hif alpha single nucletide polymorphisms snp complete blood count performed subjects results significant decrease frequency hif alpha allele subjects compared normal level hgb group high level hgb subjects significantly higher frequency hif alpha allele subjects normal level hgb group significant difference observed genotype distribution combined genotypes hif alpha normal hgb level subjects conclusion results suggest hif alpha polymorphisms may associated study population
objective social cognitive perspective posttraumatic stress disorder ptsd proposed posits impaired social cognition rooted attachment insecurity plays role development ptsd support role impaired social cognition ptsd found adults social cognitive perspective ptsd examined adolescents study sought explore differences social cognition ptsd basis attachment security examined social cognition mediator relation attachment security ptsd regard ptsd symptom change inpatient treatment method recruited adolescents inpatient psychiatric hospital adolescents parents completed assessments admission discharge results adolescents secure attachment demonstrated better social cognitive skills insecure attachment social cognition mediated relation adolescents maternal attachment representations ptsd admission across self parent report measures social cognition also mediated relation adolescents maternal attachment representations admission ptsd treatment outcome conclusion study provides support application sharp fonagy allen social cognitive perspective ptsd adolescents showing link clinically significant symptoms ptsd attachment security social cognitive impairment findings indicate improvement ptsd medium stay inpatient treatment partially driven baseline attachment security social cognitive abilities highlighting potential social cognitive skills important targets clinical intervention among adolescents ptsd
objective accumulating evidence suggests plasmacytoid dendritic cells pdc dual role initiating anti tumor immune responses also inducing immune tolerance facilitate cancer development aim study investigate distribution function tumor infiltrating pdcs primary oral squamous cell carcinoma oscc relation patient outcome methods distribution pdcs normal oral mucosa oscc tissues detected immunohistochemistry population pdcs six oscc patients six healthy donors evaluated flow cytometry relationship tumor infiltrating pdcs clinicopathological data patient outcome analyzed accordingly capacity pdcs produce cytokines ifn alpha tnf alpha response tlr ligands cpg odn measured elisa result pdcs detected high levels oscc tissues primarily stroma absent normal oral mucosa frequency pdcs oscc tissue significantly higher observed normal oral mucosa however distribution population circulating pdcs similar healthy donors oscc patients kaplan meier analysis revealed significant association increasing number tumor infiltrating pdcs lymph node metastasis overall survival multivariate analysis confirmed high levels tumor infiltrating pdcs independent prognostic factor cytokine analysis revealed decreased secretion ifn alpha tnf indicated impaired function tumor infiltrating pdcs conclusions increased number tumor infiltrating pdcs correlates adverse outcome primary oscc patients finding suggestive contribution pdcs progression oral cancer also presents opportunity new target oscc immune therapy oral cancer management elsevier ltd rights reserved
objective accurate outcome prediction models patients mild traumatic brain injury mtbi key prognostic assessment clinical decision making using multivariate machine learning tested unique added predictive value magnetic resonance imaging mri based brain morphometric volumetric characterization week postinjury demographic preinjury injury related postinjury variables month outcomes including global functioning level postconcussion symptoms mental health patients mtbi methods prospective cohort study patients aged years month follow weighted mri data processed freesurfer yielding accurate cortical reconstructions surface based analyses cortical thickness area volume brain segmentation subcortical global brain volumes month outcome defined composite score using principal component analysis including glasgow outcome scale extended rivermead postconcussion questionnaire patient health questionnaire using leave one cross validation permutation testing tested compared three prediction models mri model clinical model mri clinical combined results found strong correlation observed predicted outcomes clinical model mri model performed chance level combined model slightly weaker clinical model univariate correlation analyses revealed strongest association outcome postinjury factors posttraumatic stress posttraumatic symptom scale psychological distress hospital anxiety depression scale widespread pain assessed weeks conclusion found added predictive value mri based measures brain cortical morphometry subcortical volumes demographic clinical features
objective alterations sleep quality metabolism menopause improved menopausal hormone therapy mht mechanisms mediating effects remain unclear orexin oxa neuro peptide regulates sleep wakefulness food intake metabolism study examined changes plasma oxa levels treatment women kronos early estrogen prevention study keeps methods keeps randomized women within three years menopause oral conjugated equine estrogen cee day transdermal beta estradiol day placebo pills patches four years plasma oxa levels measured enzyme immunoassays fasting blood samples collected annually keeps participants mayo clinic three years mht changes menopausal symptoms plasma oxa levels assessed treatment differences results treatment oxa levels increased women randomized cee compared groups women randomized either form mht demonstrated smaller increases bmi placebo insomnia severity decreased similarly among treatment groups however neither changes sleep changes bmi correlated changes plasma oxa levels changes waist circumference correlated positively changes plasma oxa levels three years discontinuation study treatments conclusions although oxa levels increased women randomized cee changes correlate changes sleep quality bmi modest correlation oxa levels waist circumference study treatments discontinued suggests oxa may modulated multiple intermediary pathways affected metabolites beta estradiol published elsevier ireland ltd
objective although described ago refeeding syndrome rfs remains understudied lack standardized definition treatment recommendations aim systematic review gather evidence regarding standardized definition incidence rate time course occurrence association adverse clinical outcomes risk factors therapeutic strategies prevent treat condition methods searched medline embase interventional observational clinical trials focusing rfs excluding case reports reviews extracted data based predefined case report form assessed bias results potential abstracts records total patients included interventional trials studies focusing anorexic patients definitions rfs highly heterogenous studies relying blood electrolyte disturbances others also including clinical symptoms incidence rates varied depending definition patient population studied occurrence mostly within first start nutritional therapy risk factors accordance national institute health care excellence guidelines older age enteral feeding additional factors strong evidence regarding association rfs adverse outcomes well regarding preventive measures treatment algorithms conclusion systematic review focusing rfs found consensus regarding risk factors timing occurrence wide variations regarding definition reported incidence rates preventive measures treatment recommendations research fill gap urgently needed elsevier inc rights reserved
objective amyloid beta positron emission tomography pet imaging helps estimate neuritic plaque density patients cognitive impairment evaluation alzheimer disease study aims evaluate cost effectiveness pet scan adjunct standard diagnostic assessment diagnosis france using florbetapir example methods state transition probability analysis developed adopting french health technology assessment hta perspective per guidance parameters included test characteristics rate cognitive decline treatment effect costs quality life additional scenarios assessed validity analytical framework including earlier evaluation treatment cerebrospinal fluid csf comparator use diagnostic procedures outputs included differences quality adjusted life years qalys costs incremental cost effectiveness ratios icers benefits costs discounted time preferences sensitivity analyses performed assess robustness findings key influencers outcomes results pet used adjunct standard diagnostic assessment increased qalys years year costs euro per patient icer euro per qaly gained compared standard diagnostic assessment alone compared csf pet costs euro per qaly gained scenarios pet consistently cost effective relative commonly used affordability threshold euro per qaly simulations sensitivity analysis cost effective conclusion pet projected affordably increase qalys french hta perspective per guidance range clinical scenarios comparators input parameters
objective experiment conducted determine relationship kap regulation wool fineness methods previous work constructed skin cdna library isolated full length cdna clone termed kap basis conducted series bioinformatics analysis tissue distribution kap mrna performed using semi quantitative reverse transcription polymerase chain reaction pcr analysis expression kap mrna primary secondary hair follicles performed using real time pcr real time polymerase chain reaction analysis expression location kap mrna primary secondary hair follicles performed using situ hybridization results bioinformatics analysis showed kap gene encodes putative amino acid protein exhibited high content cysteine serine threonine valine pubertal mammary gland structural domain secondary structure prediction revealed high proportion random coils semi quantitative pcr showed kap gene expressed heart skin liver expressed spleen lung kidney real time pcr results showed expression kap higher expression catagen anagen primary hair follicles however secondary hair follicles kap significantly higher expression anagen catagen moreover kap gene strong expression inner root sheath hair matrix lower expression hair bulb conclusion conclude kap gene may play important role regulating fiber diameter
objective antiretroviral therapy art affords longevity patients infected human immune deficiency virus hiv since little known health related quality life hrqol persons art least five years present study investigated hrqol patients botswana method medical records structured interviews world health organization quality life bref whoqol hiv bref instrument employed obtain information respondents results univariate multivariate regression analyses showed respondents highest scores physical domain mean lowest scores environment domain mean thus physical domain greatest impact patients overall hrqol self education hiv related issues significantly correlated domains hrqol scores physical psychological independence social relationships environment spirituality significance results hrqol assessments identify address patients needs important guidelines developed yield improved care art patients botswana
objective endometrioma frequently recurs conservative surgery long term postoperative medical treatment prevention recurrence necessary however elucidated whether long term postoperative medical treatment crucial patients menopause thereupon study conducted evaluate age related recurrence patterns conservative surgery endometrioma study design retrospective cohort study performed total reproductive aged women underwent conservative surgery endometrioma january december ultrasonography used follow period detect endometrioma recurrence patients classified two groups according use postoperative medications first group observation second received gonadotropin releasing hormone agonists followed cyclic oral contraceptives cumulative recurrence rate endometrioma compared according age surgery years years years within group subgroup analysis performed according age two groups results median follow duration surgery months range months patients adjusting parity size bilaterality cyst stage american society reproductive medicine classification endometriosis statistically different within group treatment cumulative recurrence rate years significantly lower compared years hazard ratio confidence interval years however differences within group postoperative medical treatment compared two groups cumulative recurrence rate significantly different years years difference years conclusions preliminary results demonstrate risk endometrioma recurrence decreases age age forty recurrence rate differ according use postoperative medication based results postoperative medical treatment may individualized according patient age time surgery studies needed identify patients may benefit postoperative medication elsevier ireland ltd rights reserved
objective bilastine novel second generation antihistamine open label single arm phase iii study evaluated safety efficacy long term treatment bilastine japanese patients seasonal sar perennial allergic rhinitis par methods patients sar par met registration criteria violate exclusion criteria received bilastine daily weeks treatment period patients par met transition criteria could elect continue bilastine treatment additional weeks continuous treatment period total weeks safety tolerability primary outcomes main secondary endpoint evaluate changes efficacy variables baseline measurements results fifty eight patients sar patients par received bilastine day weeks fifty five patients par transitioned continuous treatment period adverse events aes reported patients sar patients par adverse drug reactions adrs reported patients par patients sar week treatment period adrs mild severity week treatment period aes adrs reported patients par respectively adrs occurred week treatment period none continuous treatment period aes categorized using system organ class nervous system disorders patients reported headache none reported somnolence one serious reported considered unrelated bilastine treatment deaths patients withdrew study aes patients sar bilastine significantly decreased total nasal symptom score tnss total ocular symptom score toss total symptom score tss relative baseline prolonged treatment bilastine resulted maintenance significant reduction tnss toss tss baseline patients par improvement quality life also observed patients sar par conclusion bilastine safe well tolerated effective patients sar par observed improvement maintained duration study loss drug efficacy elsevier ireland ltd rights reserved
objective bipolar disorder highly heritable neuroimaging studies comparing unaffected youth high familial risk first degree relative disorder termed high risk low risk youth without first degree relative patients may help identify potential brain based markers associated risk regions equal resilience equal illness equal method functional magnetic resonance imaging fmri youths adolescents young adults aged years performed task probing face emotion labeling previously shown impaired behaviorally youth youth results found three patterns results candidate risk endophenotypes shared deficits included dysfunction higher order face processing regions middle temporal gyrus dorsolateral prefrontal cortex candidate resilience markers disorder sequelae respectively show unique alterations relative two groups included different patterns neural responses across regions mediating face processing fusiform executive function inferior frontal gyrus social cognition default network superior temporal sulcus temporoparietal junction conclusion replicated longitudinal studies additional populations neural patterns suggesting risk endophenotypes could used identify individuals risk may benefit prevention measures moreover information risk resilience markers could used develop novel treatments recruit neural markers resilience attenuate neural patterns associated risk
objective cardiovascular disease cvd leading cause morbidity mortality hiv emerging cvd risk factor triglyceride rich remnant lipoprotein cholesterol rlp sum intermediate density lipoprotein low density lipoprotein cholesterol effects statin therapy lipoprotein subfractions including rlp hiv dyslipidemia unknown methods post hoc analysis randomized intrepid trial nct comparing pitavastatin daily pravastatin daily study participants hiv measured apolipoproteins lipoprotein cholesterol subfractions separated density gradient ultracentrifugation baseline weeks compared changes atherogenic subfractions weeks intrepid participants using analysis covariance results lipoprotein subfraction data available study participants pitavastatin pravastatin baseline characteristics similar treatment groups reductions rlp significantly greater pitavastatin group compared pravastatin group similarly ratios risk apolipoproteins apolipoproteins total cholesterol high density lipoprotein cholesterol hdl showed greater reductions pitavastatin differences changes hdl hdl subfractions lipoprotein cholesterol levels conclusion patients hiv pitavastatin lowered rlp established apolipoprotein lipid risk ratios pravastatin impact rlp reduction cvd hiv dyslipidemic patients merits study copyright wolters kluwer health inc rights reserved
objective carrageenan induced edema described highly reproducible model acute inflammation however little known cytokines attributed induced inflammation study aimed investigate local systemic expression profiles various inflammatory cytokines following subplantar injection rats methodology acute inflammation induced male wistar rats subplantar injection serum paw tissue examined level specific inflammatory cytokines using antibody array elicited level key inflammatory cytokines cytokine induced neutrophil chemoattractant cinc cinc interleukin tumor necrosis factor tnf quantified enzyme linked immunosorbent assay elisa results edema peaked postinjection hind paw among specific cytokines profiled using antibody array significantly elicited levels cinc cinc ngf tnf vegf paw tissue cinc cinc serum consistently levels cinc cinc tnf tissue cinc cinc serum upregulated treated rats compared control quantified elisa conclusions study corroborates distinct pattern inflammatory cytokines involved induced acute inflammation furthermore data provide new evidence elevated expression rat cxc chemokines cinc cinc site inflammation well significant reflection circulation thereby suggesting frontline role induced acute inflammation
objective centrally active alpha adrenergic receptor antagonists prazosin effective treatment nightmares patients posttraumatic stress disorder ptsd pharmacological alternative doxazosin longer half life fewer side effects however doxazosin currently used without solid empirical evidence furthermore study far assessed effects alpha antagonists nightmares patients borderline personality disorder bpd retrospectively assessed effectiveness doxazosin nightmares ptsd bpd method retrospective chart review patients treated doxazosin trauma associated nightmares clinic performed previous prazosin studies score clinician administered ptsd scale caps used primary outcome measure furthermore pittsburgh sleep quality index addendum ptsd psqi sleep logs analyzed results identified patients ptsd bpd mean age years women received doxazosin nightmares patients continued doxazosin week period patients week period within week period doxazosin treatment significantly reduced nightmares regardless ptsd bpd percent patients treated weeks full remission nightmares psqi scores indicated additional trauma associated sleep symptoms improved weeks furthermore recuperation sleep improved doxazosin within first weeks treatment conclusion doxazosin might improve trauma associated nightmares general sleep parameters patients ptsd bpd randomized controlled trials warranted
objective child abuse devastating mental health consequences fortunately individuals exposed child abuse suffer poor mental health understanding factors related good mental health following child abuse provide evidence inform prevention impairment objectives describe prevalence good moderate poor mental health among respondents without child abuse history examine relationships child abuse good moderate poor mental health outcomes examine relationships individual relationship level factors better mental health outcomes determine individual relationship level factors moderate relationship child abuse mental health method data nationally representative canadian community health survey mental health household response rate years older good moderate poor mental health assessed using current functioning well past year mental disorders past year suicidal ideation results respondents child abuse history report good mental health compared without child abuse history individual relationship level factors associated better mental health included higher education income physical activity good coping skills handle problems daily demands supportive relationships foster attachment guidance reliable alliance social integration reassurance worth conclusions study identifies several individual relationship level factors could targeted intervention strategies aimed improving mental health outcomes following child abuse
objective community acquired pressure ulcers prus frequent cause hospitalization veterans spinal cord injury sci veterans health administration vha recommends sci annual evaluations include assessment pru risk factors thorough skin inspection sharing recommendations pru prevention strategies characterized consistency preventive skin care annual evaluations veterans sci first step identifying strategies actively promote pru prevention care healthcare encounters design setting participants retrospective cross sectional observational design including review electronic medical records veterans sci admitted sci centers january december outcome measures proportion applicable skin health elements documented number applicable elements skin health elements documented results sample primarily white male mean age years participants hospitalized pru treatment mean days median days annual evaluation index admission average veterans received average iqr applicable skin health elements documentation applicable skin health elements significantly higher inpatient outpatient annual evaluations mean elements received respectively significant differences observed documentation skin health elements veterans high low pru risk conclusion additional pru preventive care vha outpatient setting may increase identification detection pru risk factors early pru damage veterans sci community allowing earlier intervention
objective depression screening increased prevailing knowledge underscoring medication associated mental health risk highest depression screening primary care practices medications mental health risk prescribed estimated considering absence presence clinical decision support systems materials methods cross sectional descriptive study using national ambulatory medical care survey namcs data conducted primary care physician visits classified based whether medication prescribed contraindication severe warning moderate warning adverse event documented mental health risk adjusted odds depression screening risk warning level estimated controlling important sociodemographic factors presence computerized systems medication warnings guideline recommendations results depression screening primary care practice visits medications prescribed increased higher medications moderate severe mental health risk warning medication disease contraindication depression screening increased visits least one medication prescribed contraindication aor severe warning aor moderate warning aor mental health risk mental health adverse event warnings alone aor discussion depression screening increased medications prescribed documented mental health risk presence clinical decision support systems may help discern minor major medication associated mental health risks conclusions appropriately positioned warning systems targeted content workflow redesign health information exchange may improve depression screening risk patients elsevier inc rights reserved
objective despite huge efforts chronic kidney disease ckd remains unsolved problem medicine many studies shown central role transforming growth factor beta tgf beta downstream signaling cascades pathogenesis ckd study reanalyzed microarray dataset recognize critical signaling pathways controlled tgf beta materials methods study bioinformatics reanalysis microarray data gse dataset downloaded gene expression omnibus geo database assesses mrna expression profile tgf beta treated human kidney cells hours incubation protein interaction networks differentially expressed genes time points constructed enriched addition network topology analysis genes high centrality identified pathway enrichment analysis performed either total network genes central nodes results found genes differentially expressed time points hours respectively genes time point interactions networks enriched adding previously known genes interacting differentially expressed ones terms degree betweenness closeness centrality parameters nodes considered central enriched networks hours hours treatment respectively pathway enrichment analysis central nodes informative network nodes even initial genes revealing key signaling pathways conclusion introduced method analysis microarray data integrates expression pattern genes topological properties protein interaction networks holistic novel approach allows extracting knowledge raw bulk omics data
objective despite widespread use little data investigating long term impact micronutrients psychiatric disorders study investigated naturalistic outcome year post baseline randomized controlled trials rct compared micronutrients placebo adults adhd method participants contacted clinician rated questionnaires completed results total sample participated although significant regression psychiatric functioning end trial measures outcomes remained significantly improved baseline dominant treatment end treatment follow investigated mediator outcome staying micronutrients performed better switched medications discontinued micronutrients cost substantial reason people stopped micronutrient treatment conclusion small number participants stayed micronutrients benefits conferred controlled trial maintained results limited small sample lack blinding expectation reliance self report symptoms
objective emotion processing abilities might reduced amyotrophic lateral sclerosis als previous studies emotion processing als inconsistent results limited variations task difficulty modalities examined participants cognitive status current study used battery emotion processing tasks differing levels difficulty across different modalities facial affect voice prosody assess extent emotion processing deficits nondemented als method als participants intact basic cognition healthy controls completed abbreviated comprehensive affect testing system cats assesses simple complex facial affect recognition affective prosody recognition cross modal face prosody integration semantic comprehension affect participants also completed measures executive function mood functional impairment results als participants showed impairments complex facial affect recognition affective prosody recognition cross modal integration contrast simple facial affect recognition semantic comprehension affect intact als participants significant mood symptoms neither mood functional impairment related emotion processing performance cross modal composite related executive function however relationship apparent facial prosody recognition within single modality conclusions results indicate people living als without dementia often subtle difficulties recognizing emotions faces voices even context intact basic cognition clinicians aware potential emotion processing difficulties present als affect interpersonal behavior quality life
objective fibromyalgia prevalent disorder characterized chronic widespread pain complex symptoms study conducted investigate potential therapeutic effect low dose irradiation ldi alone combination duloxetine reserpine induced fibromyalgia rats methods fibromyalgia induced administration reserpine consecutive days duloxetine administered min forced swimming test fst rats exposed single dose radiation day fst results reserpine significantly increased immobility time fst decreased amount hydroxytryptamine dopamine norepinephrine cerebral cortex also increased malondialdehyde nitric oxide reduced glutathione contents brain tissue ldi alone combined duloxetine completely antagonized reserpine induced fibromyalgia assessed measured parameters one significant findings study therapeutic effect duloxetine pronounced combination ldi possible mechanism action ldi duloxetine responsible therapeutic effect discussed conclusion basis presented evidences could concluded ldi alone combined duloxetine could value management fibromyalgia
objective fixed incentives largely unsuccessful improving adherence antiretroviral medication therefore evaluate whether small incentives based behavioral economic theory increase adherence antiretroviral medication among treatment mature adults kampala uganda design randomized control trial design tests whether providing small incentives based either attending timely clinic visits intervention group achieving high medication adherence intervention group increase antiretroviral adherence antiretroviral adherence measured medical event monitoring system mems caps methods overall hiv infected men women age randomized one two intervention groups received small prizes awarded drawing conditional either attending scheduled clinic appointments achieving least antiretroviral adherence control group received usual standard care results preliminary results based pooling intervention groups showed individuals receiving incentives percentage points likely achieve antiretroviral adherence compared control group confidence interval specifically participants pooled intervention groups maintained least mean adherence first months intervention compared control group conclusion small prize incentives resulted statistically significant increase antiretroviral adherence although traditional fixed incentives produced desired results findings suggest small incentives based behavioral economic theory may effective motivating long term adherence among treatment mature adults copyright wolters kluwer health inc rights reserved
objective hispanic youth general community experience traumatic events display symptoms psychological distress frequently caucasian youth however little known traumatic experiences ethnic minority population relate psychopathology clinical samples whether outcomes vary gender impacted family functioning hypothesized traumatic stress reactions including posttraumatic stress disorder ptsd internalizing externalizing symptoms would vary gender family functioning clinical sample hispanic youth method current study utilized baseline data randomized clinical trial rct involving hispanic adolescents boys girls referred treatment experiencing clinical symptoms behavioral disorders conflictual family relations rate traumatic events differences outcomes depending trauma exposure effects gender family functioning trauma psychopathology ptsd symptoms examined results analyses revealed hispanic youth clinical sample experienced least traumatic event although sample reported ptsd scores clinical range girls reported higher ptsd scores boys poor family cohesion particularly detrimental girls compared boys related internalizing ptsd symptoms high family conflict predicted ptsd symptoms boys girls conclusions findings clinical implications working hispanic populations suggesting culturally sensitive interventions incorporate family based interventions individuals experience trauma strengthen family bonds decrease family conflict
objective historically shown rheumatoid arthritis periodontitis share pathophysiological similarities possibly genetic background order elucidate genetic background diseases evaluated distributions five snps genotypes possible haplotypes composed subjects isolated combined diseases healthy controls materials methods study population consisted mexican subjects genomic dna isolated buccal epithelial cells collected cheek scrapings analyzed determination following snps alpha alpha beta beta tnf alpha results adjustment age sex smoking status multiple logistic regression analysis revealed significant association genotype frequencies tnf alpha alpha snps otherwise significant association observed beta beta alpha borderline statistical significance also found three negative associated haplotypes alpha beta beta beta interestingly alpha beta also positive association conclusions genotypes haplotypes associated diseases seems genetic background association needs explored deeper
objective hyperinsulinemia prevalent feature polycystic ovary syndrome pcos contributing metabolic reproductive manifestations syndrome weight loss reduces hyperinsulinemia weight regain norm thus preventing long term benefits absence weight loss replacement dietary carbohydrate cho mono polyunsaturated fat reduces ambient insulin concentrations non pcos subjects current study evaluated whether dietary intervention could ameliorate hyperinsulinemia women pcos design setting patients obese women pcos bmi insulin resistance completed crossover study stanford university clinical research center comparing two isocaloric diets prepared research dietitians containing cho fat versus cho fat protein saturated fat weeks diet daylong glucose insulin fasting lipid lipoproteins measured results daylong glucose differ according diet daylong insulin concentrations substantially significantly lower low cho higher fat diet beneficial changes lipid profile also observed conclusions replacement dietary cho mono polyunsaturated fat yields clinically important reductions daylong insulin concentrations without adversely affecting lipid profile obese insulin resistant women pcos simple safe dietary intervention may constitute important treatment pcos clinicaltrials gov identifier nct
objective immune responses change exercise aimed show changes cytokine levels pre post exercise patients asthma methods prospective control trial data patients asthma control classified two groups pre post exercise serum beta monocyte beta expressions evaluated using enzyme linked immunosorbent assay patients advised walk least min days week weeks results significant difference demographic properties participants monocyte beta levels pre post exercise groups respectively levels pre post exercise groups respectively levels pre post exercise groups respectively however significant difference serum beta monocyte beta levels groups respectively conclusion systemic inflammatory parameters commonly elevated asthma may improve exercise elucidation mechanism immune control patients asthma useful future treatment asthma
objective centers medicare medicaid services enacted nonpayment policy stage iii hospital acquired pressure ulcers hapus incentivized hospitals improve prevention efforts response hospitals looked ways support implementation evidence based practices hapu prevention adoption quality improvement interventions objective study quantify adoption patterns interventions supporting evidence based practices hapu prevention methods study surveyed wound care specialists working hospitals within university healthsystem consortium questionnaire used retrospectively describe adoption patterns according hapu specific interventions four domains leadership staff information technology performance improvement respondents indicated interventions implemented nearest quarter year descriptive statistics defined patterns adoption test statistical process control chart established statistically significant increase adoption following nonpayment policy enactment october increase described terms scope number domains employed scale number interventions within domains results fifty three hospitals surveyed reported implementing interventions hapu prevention leadership interventions frequent increasing scope annual programs promote pressure ulcer prevention showed greatest increase scale staff interventions increased scope frequent consult driven huddles showed greatest increase scale interventions increased scope performance improvement interventions increased scope new skin care products increasing linking evidence action academic medical centers increased adoption interventions following changes nonpayment policy interventions supported adherence implementation pressure ulcer prevention protocols changes payment policies prevention effective efforts
objective aggregatibacter actinomycetemcomitans different serotypes described based lipopolysaccharide lps antigenicity lymphocytes stimulated serotypes different patterns helper type immune responses reported recently two new phenotypes described named lymphocytes however role pathogenesis periodontitis remains unclear study aimed investigate potential lymphocyte responses stimulated autologous dendritic cells infected different actinomycetemcomitans serotypes methods monocyte derived dendritic cells naive lymphocytes obtained healthy donors stimulated different serotypes actinomycetemcomitans multiplicity infection moi purified lps levels associated cytokines well transcription factor master switch genes implied differentiation spi ahr quantified qpcr elisa results stimulated serotype actinomycetemcomitans higher levels interleukin tumor necrosis factor tnf alpha detected dendritic cells well higher levels ahr detected lymphocytes compared stimulation serotypes conclusions serotype actinomycetemcomitans higher capacity trigger type immune response dendritic cells lymphocytes data allow suggest serotype actinomycetemcomitans significant part subgingival biofilm polarization might triggered within periodontal lesion elsevier ltd rights reserved
objective study aimed evaluate plasma homocysteine levels oxidative stress parameters patients adult adhd adhd method blood samples taken adhd patients controls enrolled study plasma homocysteine serum folate vitamin total antioxidant status tas total oxidant status tos oxidative stress index osi determined results compared groups results patients plasma homocysteine level significantly lower serum folate level significantly higher controls means plasma homocysteine folate levels statistically significantly different groups conclusion study suggests oxidative balance impaired adhd contrary psychiatric disorders homocysteine levels found lower
objective patients anorexia nervosa specific signs may occur oral cavity conflicting reports significance especially concerning changes salivary composition aim clinical study evaluate resting parotid flow rate pfr activity following enzymes parotid saliva amylase aspartate amino transferase ast lysozyme peroxidase serine acidic proteases acute phase restrictive type compare findings healthy controls design forty one subjects participated patients matched healthy controls parotid saliva collected using modified lashley cap rest enzyme activities measured fluorimetric photometric assays results unstimulated pfr significantly lower controls lysozyme ast activity significantly lower amylase showed high inter individual variability positive correlation amylase lysozyme negative ones lysozyme bmi lysozyme ibw serine protease salivary flow observed conclusions reduced pfr enzyme activities levels suggest affect quantity saliva also quality biological functions results obtained help provide better understanding effect disease pathogenesis least oral diseases research needed possible role reduced lysozyme transaminase activity maintaining oral protection external toxic agents bacteria elsevier ltd rights reserved
objective patients cerebral palsy psychological problems influence participation society little known persistence behavioral social problems adulthood materials methods two center cross sectional study caregivers adults children ask assess behavior patients parent caregiver forms child behavior checklist cbcl strengths difficulties questionnaire sdq vineland adaptive behavior scale vabs questionnaires returned adults children results groups found frequency abnormalities attention problems social interaction problems cbcl peer problems sdq children show lower percentage abnormal prosocial behavior lower abnormal rates communication daily living skills whereas level abnormalities groups dimensions vabs notably high conclusion persistence psychological social problems childhood adulthood underlines importance focusing early intervention european paediatric neurology society published elsevier ltd rights reserved
objective recent decades alexithymia considered risk factor multiple somatic psychiatric conditions yet whereas alexithymia extensively studied adults substance misuse one study reported data cannabis abusers general population hence main objective explore alexithymia clinical sample treatment seeking young outpatients dsm cannabis dependence abuse diagnosis compared controls methods young patients males mean age years cannabis dependence abuse dsm criteria evaluated mini seeking treatment addiction unit healthy control subjects males mean age years participated study completed battery self reports measuring alexithymia tas bvaq depression bdi state trait anxiety stai results cannabis users alexithymic logistic regression analysis showed alexithymic components difficulties identifying describing feelings combined trait anxiety predicted group membership conclusion first study young cannabis abusers dependent subjects emphasizes importance considering affective style particularly anxious temperament alexithymia features factors associated substance misuse late adolescence elsevier inc rights reserved
objective insomnia disorder risk factor cardiovascular pathology unknown whether insomnia develops context menopausal transition impacts system assessed nocturnal blood pressure heart rate profiles women insomnia disorder methods twelve women meeting dsm criteria insomnia age mean controls age mean polysomnographic recordings one two nights beat beat assessed analyzed hourly lights across first hours night according sleep stage physiological hot flashes identified fluctuations sternal skin conductance results women insomnia controls similar distributions sleep stages awakenings arousals across hours night although insomnia participants tended wakefulness overall women insomnia group control group least one physiological hot flash night groups showed drop first part night however systolic diastolic patterns diverged later remaining low controls increasing insomnia participants hours lights groups showed similar pattern decline across night conclusions findings suggest altered regulatory control sleep insomnia causes long term consequences altered nocturnal profile remain determined
objective internet gaming disorder igd type behavioral addiction characterized abnormal executive control leading loss control excessive gaming attention deficit hyperactivity disorder adhd one common comorbid disorders igd involving delayed development executive control system could predispose individuals gaming addiction investigated influence childhood adhd neural network features igd methods resting state functional magnetic resonance imaging analysis performed young male igd subjects without childhood adhd age matched healthy male controls posterior cingulate cortex pcc seeded connectivity evaluated assess abnormalities default mode network dmn connectivity associated deficits executive control results igd subjects without childhood adhd showed expanded functional connectivity dmn related regions pcc medial prefrontal cortex thalamus compared controls subjects also exhibited expanded pcc brain regions implicated salience processing anterior insula orbitofrontal cortex compared igd subjects childhood adhd igd subjects childhood adhd showed expanded pcc cerebellum crus region involved executive control strength connectivity pcc cerebellum crus positively correlated self reporting scales reflecting impulsiveness conclusion individuals igd showed altered pcc based characteristics might dependent upon history childhood adhd findings suggest altered neural networks executive control adhd would predisposition developing igd elsevier inc rights reserved
objective low testosterone levels increased aortic stiffness predictors cardiovascular events influence androgen level age blood pressure related increase aortic stiffness unknown methods january june enrolled consecutive men evidence cardiovascular disease large cohort followed department arterial function studies total testosterone levels measured carotid femoral pulse wave velocity pwvc measured index aortic stiffness results multivariable analysis pwvc values inversely correlated adjustment confounders beta younger age categories yrs yrs patients testosterone deficiency higher blood pressure adjusted pwvc mmhg patients higher age adjusted pwvc compared subjects normal indicating synergistic unfavorable effect testosterone deficiency blood pressure aortic stiffness conclusions levels independently associated aortic stiffening effect low testosterone concentration aortic stiffness prominent young men subjects higher blood pressure levels findings identify testosterone marker arterial damage special emphasis young hypertensive individuals support role predictor events published elsevier ireland ltd
objective theanine amino acid uniquely contained green tea camellia sinensis suggested various psychotropic effects study aimed examine whether theanine effective patients major depressive disorder mdd open label clinical trial methods subjects patients mdd four males mean age years females years theanine day added current medication participant weeks symptoms cognitive functions assessed baseline weeks theanine administration item version hamilton depression rating scale hamd state trait anxiety inventory stai pittsburgh sleep quality index psqi stroop test brief assessment cognition schizophrenia bacs results hamd score reduced theanine administration reduction observed unremitted patients hamd baseline anxiety trait scores decreased theanine administration stai test psqi scores also decreased theanine administration unremitted patients baseline regarding cognitive functions response latency error rate decreased stroop test verbal memory executive function enhanced bacs test theanine administration conclusion study suggests chronic week theanine administration safe multiple beneficial effects depressive symptoms anxiety sleep disturbance cognitive impairments patients mdd however since open label study placebo controlled studies required consolidate effects
objective medical students exposed various psychosocial problems challenges specific consultations services programs support christian vajda medical university graz department medical peerpeer consultation program implemented medical university graz focusses crisis intervention psychology psychosocial stress management junior mentoring well student psychotherapy graz austria education field besides also offers student tutors program practical skills trainings program restructured winter term methods one hand peerpeer gives insights topics current state research concerning students psychological strain psychosocial crises acutely stressful situations preventive approaches coping kinds situations hand aspects taught means elective courses lectures workshops furthermore peerpeer provides consultation services student tutors give face face advice required tutors receive ongoing training organizational professional issues results since summer term students trained via lectures elective courses contacts short consultation contacts full consultation supervisied total two psychotherapeutic one psychosocial follow ups recommended seven students participate tutors program conclusions peerpeer program intended enable low threshold access medical students facing psychosocial crises situations help dealing stress learning problems increase support contacts summer term winter term considered success first evaluation different components program started winter semester student tutors acquired practical skills dealing students crises situations also various organizational skills
objective menopause widely believed established cause sleep disorders evidence theory inconclusive attributing sleep problem normal processes menopause may lead underdiagnosis treatable sleep disorders midlife women study uses detailed longitudinal data sleep menopausal health participants sleep midlife women study investigate whether risk severity sleep disordered breathing increase progression menopause accounting changes age body habitus methods total women aged years recruited participants wisconsin sleep cohort study menopause status determined daily diaries participants reported menstrual flow hot flashes use hormonal medications participant underwent home polysomnography studies every months measure apnea hypopnea index ahi studies linear models empirical standard errors fit logarithm ahi menopause status years menopause adjusting age body mass index waist girth neck girth results compared women premenopause ahi higher among participants perimenopause higher among participants postmenopause higher among participants whose menopausal stage could distinguished peri postmenopause among women begun perimenopause additional year menopause associated greater ahi conclusions progression menopause associated greater sleep disordered breathing severity association independent aging changes body habitus
objective women alzheimer disease men understanding sex differences mild cognitive impairment mci may knowledge etiology prevention conducted meta analysis examine sex differences prevalence incidence mci included amnestic non amnestic subtypes method systematic searches performed july using medline pubmed scopus psycinfo population community based studies mci data men women random effects model used results fifty six studies included statistically significant sex differences prevalence incidence amnestic mci significantly higher prevalence incidence non amnestic mci among women sex differences studies combined subtypes mci conclusion statistically significant finding emerging study women higher prevalence non amnestic mci better understand sex differences preclinical stages dementia studies must better characterize etiology cognitive impairment elsevier rights reserved
objective multimorbidity related menopause increased age put healthcare systems western nations ever greater strain effective strategies prevent diseases thus high priority started earlier life purpose study evaluate long term effect exercise different important health parameters initially early postmenopausal women year period methods early postmenopausal women osteopenia living erlangen nurnberg included study eighty six women joined exercise group conducted two supervised group two home training sessions per week whereas control group maintained physical activity level primary outcome parameters clinical overall fractures incidence secondary study endpoint framingham study based year risk coronary death myocardial infarction low back pain results women women included year follow analysis framingham study based year risk myocardial infarction coronary death increased significantly groups however changes significantly favorable ratio clinical overall fractures thus significantly lower although focused high intensity exercise strategy low back pain favorably affected conclusions multipurpose exercise programs demonstrated beneficial effects various relevant risk factors diseases menopause increased age thus preferentially applied primary secondary prevention postmenopausal women
objective non response antidepressant treatment substantial problem primary care many patients depression require additional second line treatments study aimed examine prevalence patterns antidepressant switching identify associated demographic clinical factors method cohort analysis antidepressant prescribing data clinical practice research datalink large anonymised primary care database sample included patients initiated antidepressant therapy january june results patients switched different antidepressant product switches occurring within weeks index date proportion switching similar selective serotonin reuptake inhibitors ssris tricyclic antidepressants antidepressants respectively switches ssri preferred option regardless initial antidepressant class factors predictive switching included male gender age history self harm psychiatric illness conclusion one every patients initiates antidepressant therapy switch medication suggesting initial antidepressant treatment unsatisfactory evidence guide choice second line treatment individual patients currently limited additional research comparing different pharmacological psychological second line treatment strategies required order inform guidelines improve patient outcomes
objective nowadays psoriasis accepted autoinflammatory autoimmune disease result chronic inflammation psoriasis widely investigated associated diseases comorbidities however limited data effects psoriasis hearing functions aim study investigate prospectively patients psoriasis sensorineural hearing loss effect disease severity hearing levels methods overall patients ears psoriasis healthy controls ears included study otoscopic examination pure tone air bone conduction including high frequencies speech audiometry performed participants results median pure tone average patients significantly different controls moreover frequency levels patients psoriasis ears significantly different control group limitation study patients investigated psoriatic arthritis sera patients also investigated anti bodies inner ear antigens anti connexin anti dep anti conclusion possibility inner ear involvement kept mind psoriasis result chronic systemic inflammation patients psoriasis may evaluated audiometry periodically even exhibit hearing problems
objective parents play important role children illness management promoting child adjustment reducing behavior problems little research focused evaluation parenting interventions context childhood chronic illness aim study test efficacy brief group parenting intervention healthy living triple improving parenting skills parent adjustment reducing child behavioral emotional difficulties context childhood asthma eczema method one hundred seven parents children diagnosis asthma eczema randomly assigned intervention care usual cau parents completed self report measures child behavioral emotional adjustment parenting level adjustment pre postintervention month follow parent child interactions observed coded time point intervention consisted group sessions delivered trained accredited practitioners results attrition low assessment completed intervention families cau families respectively intention treat analyses indicated overall parent reported ineffective parenting well parental overreactivity reduced result intervention parent report child behavior problems also decreased changes children emotional adjustment changes observed parent child behavior found stress reduced parents intervention group compared cau group changes parental anxiety depression effects showed evidence reliable clinical change maintained month follow conclusions intervention shows promise addition clinical services children asthma eczema may broader application chronic health conditions
objective pathomechanisms sedentary behaviour unclear conducted systematic review investigate associations various biomarkers older adults methods electronic databases searched medline embase cinahl amed july identify studies objective subjective measures sample size mean age years accelerometer wear time days methodological quality appraised casp tool protocol pre specified prospero crd results abstracts retrieved full text articles explored excluded final sample articles total biomarkers detected investigated markers body mass index bmi waist circumference blood pressure triglycerides high density lipoprotein hdl inflammation markers identified interleukin reactive protein tumor necrosis factor alpha lack renal muscle bone biomarkers randomized controlled trials found positive correlation bmi neck circumference fat mass hba cholesterol insulin levels cohort studies additionally leptin peptide apoa low density lipoprotein negative correlation hdl conclusion studied biomarkers associated cardiovascular metabolic origin suggestion negative impact biomarkers still paucity high quality investigations exist longitudinal studies objectively measured needed elucidate pathophysiological pathways possible associations unexplored biomarkers authors published elsevier
objective prediabetes patients likely develop type diabetes tdm low testosterone risk factor impaired glucose tolerance igt men aim study investigate prevalence prediabetes population polish men late onset hypogonadism loh methods study performed men loh eugonadal control group prediabetes diagnosed patients impaired fasting glucose ifg igt hbac sex hormones metabolic parameters measured results mean concentration loh group nmol nmol control group observed negative relationships cft hbac hbac loh group prediabetes diagnosed men control group prediabetes diagnosed patients loh group cft levels lower prediabetic patients compared normoglycemic patients patients igt lower levels subgroups ifg elevated hbac conclusions population polish men loh observed high prevalence prediabetes routine fasting glucose glucose tolerance test performed patients
objective previous studies reported association among serum uric acid sua levels cardiovascular cause mortality however results inconsistent aim study investigate whether sua independently associated cardiovascular cause mortality relatively healthy korean adults methods total individuals enrolled study participants excluded various reasons cause cardiovascular mortality data collected cox proportional hazards models used estimate adjusted hazard ratios confidence intervals cause cardiovascular mortality according baseline uric acid quintiles third middle sua quintile reference group results total participants considered eligible analysis median follow duration years lowest highest quintiles sua less men less women respectively total deaths cardiovascular disease causes occurred follow highest sua group adjusted hazard ratios cause mortality men women cardiovascular mortality men women adjustment various possible confounding factors conclusion current large relatively healthy population based observational study sua showed significant association cause cardiovascular mortality
objective prisoners increased risk self harm suicide compared general population risk suicide release prison three times greater still incarcerated however surprisingly little known incidence self harm following release prison aimed determine incidence identify risk factors characterise emergency department presentations resulting self harm adults release prison method cohort study adults interviewed prior release prison linked prospectively state correctional emergency department records data emergency department presentations resulting self harm secondarily coded characterise presentations used negative binomial regression identify independent predictors presentations results person years follow median years per participant emergency department presentations participants presented due self harm accounting presentations crude incidence rates self harm males females confidence interval confidence interval per person years respectively presenting due self harm associated indigenous incidence rate ratio confidence interval lifetime history mental disorder incidence rate ratio confidence interval previously hospitalised psychiatric treatment incidence rate ratio confidence interval previously presented due self harm incidence rate ratio confidence interval conclusion following release prison one prisoners presented emergency department due self harm within average years release demographic mental health variables help identify risk groups presentations could provide opportunities suicide prevention population transition prison community challenging particularly history mental disorder mental health support release may reduce risk adverse outcomes including self harm
objective several attributes female reproductive history including age natural menopause anm related primary open angle glaucoma poag assembled previously reported common genetic variants predict anm determine association anm poag methods using data nurses health study women validated anm weighted genetic risk score relation self reported anm subsequently assess relation poag used data female poag cases controls national eye institute glaucoma human genetics collaboration heritable overall operational database neighborhood consists datasets imputed genotypes million markers associations poag assessed dataset site specific results meta analyzed using inverse weighted variance method results genetic risk score associated self reported anm predicted variance anm anm genetic risk score associated poag odds ratio confidence interval single genetic variant panel achieved nominal association poag compared middle percent also association lowest percentile highest percentile genetic risk score poag respectively conclusions genetic risk score predicting anm variation related poag thus genetic determinants anm unlikely explain previously reported association two phenotypes
objective subdermal contraceptive implant continuation well studied africa conducted secondary data analysis compare baseline characteristics kenyan women continued use subdermal implant months study design kenyan women aged years presented family planning clinic short acting hormonal contraception offered two rod subdennal implant instead participants followed months initiation contraceptive method statistical analysis included pearson chi square fisher exact tests comparisons proportions risk ratios rrs confidence intervals cis calculated determine factors associated continuation results eighty six women chose implant followed months women continued use implant none factors examined statistically significant association continued use implant duration intended use strong factor women years need continued using implant compared shorter needs risk ratio substantive continuation differences found comparing participant characteristics including months current partner personal desire partner preference future children previous use modern birth control factors conclusion high implant continuation rates noted regardless previous use modern birth control partner preference children baseline concern menstrual change implications contraceptive use africa continues focus short acting contraceptives despite proven superior efficacy long acting reversible contraceptives settings high subdennal implant continuation among kenyan women prospective study regardless baseline characteristics supports need increasing access future research population elsevier inc rights reserved
objective substituting low dose ethinyl estradiol hormone free interval combined oral contraceptives cocs may enhance ovarian suppression improve tolerability noncomparative phase study evaluated efficacy safety active coc regimen including days desogestrel dsg followed days study design multicenter open label phase single arm study enrolled sexually active women aged years risk pregnancy women received year consecutive day cycles dsg mcg mcg days mcg alone days participants kept diaries record compliance bleeding spotting contraceptive use efficacy measured using pearl index life table approach safety tolerability assessed primarily reported adverse events aes results total women enrolled completed study forty six pregnancies women aged years occurred coc initiation days last dsg tablet taken cycles another contraceptive method used excluded confidence interval cumulative pregnancy rate year treatment users aged years cycles women considered compliant included aes similar seen oral contraceptives conclusions active dsg coc days low dose efficacious well tolerated pregnancy prevention elsevier inc rights reserved
objective sudden cardiac arrest caused cardiac arrhythmias leading causes death worldwide implantable cardioverter defibrillators icds considered standard care patients increased risk arrhythmias however icd patients experiences psychological distress post icd implantation web based distress management program icd patients webcare developed mitigate anxiety depression enhance health related quality life icd patients study investigates months outcomes method total consecutive icd patients referral hospitals netherlands randomized either webcare usual care group patients webcare group received online weeks fixed lesson behavioral treatment based problem solving therapy patients usual care group receive care usual results current findings show significant difference anxiety depression quality life webcare usual care group months postimplantation conclusions clinical trial web based behavioral intervention icd patients web based treatment superior usual care long term regarding patient reported outcomes future studies warranted examine applicability blended care models focus personalizing program order increase adherence improve outcomes
objective aim study assess efficacy safety rad oral estrogen receptor ligand treatment moderate severe vasomotor symptoms menopause methods randomized placebo controlled double blind dose ranging proof concept trial postmenopausal women minimum moderate severe diary reported hot flashes per day per week randomized one five blinded dose groups placebo rad daily efficacy endpoints included frequency severity hot flashes weeks treatment results one hundred participants randomized across five treatment regimens frequency moderate severe hot flashes decreased groups treatment period mean percent change baseline placebo groups response group significantly different placebo weeks dose group significantly different placebo statistically significant differences severity hot flashes placebo dose group treatment well tolerated treatment emergent adverse events mild moderate severity conclusions daily treatment rad weeks resulted statistically significant reduction frequency moderate severe hot flashes compared placebo acceptable safety profile clinical trials warranted investigate rad utility potential treatment vasomotor symptoms
objective aim study analyze impact psychiatric comorbidity severity dependence health related quality life hrqol methods one hundred ninety eight substance use disorder sud patients recruited outpatient center provides treatment sud international personality disorder examination screening questionnaire ipde mini international neuropsychiatric interview mini substance dependence severity scale sdss health related quality life drug abusers test hrqolda test administered results patients psychiatric comorbidity evaluated hrqol negatively patients without psychiatric comorbidity analysis relationship severity dependence hrqol scores indicated significant correlations among alcohol cocaine heroin cannabis dependent patients according multivariate analyses anxiety disorders mood disorders severity dependence alcohol cannabis cocaine paranoid borderline avoidant personality disorders pds observed major impact hrqol conclusions sud severity dependence alcohol cannabis cocaine mental disorders anxiety disorders mood disorders paranoid borderline avoidant pds involved deterioration sud patients hrqol study demonstrates need integrated treatment sud patients treating part problem whether sud mental disorders present insufficient improving quality life
objective aim study evaluate impact mindfulness based interventions psychological physical health outcomes adults overweight obese methods searched electronic databases randomized controlled trials prospective cohort studies met eligibility criteria comprehensive meta analysis software used compute effect size estimate hedge results fifteen studies measuring post treatment outcomes mindfulness based interventions individuals identified average weight loss overall effects large improving eating behaviours medium depression anxiety eating attitudes small body mass index bmi metacognition outcomes therapeutic effects bmi anxiety eating attitudes eating behaviours remained significant examining results higher quality randomized control trials alone efficacy advantage studies exceeding median dose face face intervention studies utilizing acceptance commitment therapy approach provided significant effect improving bmi mindfulness approaches produced great variation small large effects across range psychological health eating related constructs finally limited longitudinal data suggested maintenance bmi eating attitudes gains follow detectable lower quality prospective cohort studies conclusions mindfulness based interventions may physically psychologically beneficial adults overweight obese high quality research examining mechanisms action encouraged
objective aim study evaluate relationship maternal age childbirth metabolic syndrome postmenopausal women methods carried cross sectional study korean postmenopausal women participated korea national health nutrition examination survey multivariate logistic regression used evaluate association maternal age first last childbirth metabolic syndrome adjustment potential confounding variables results women metabolic syndrome younger age first delivery older age last delivery without metabolic syndrome adjustments confounding factors earlier ages first last childbirth positively associated metabolic syndrome odds ratio age first childbirth age last childbirth among components metabolic syndrome fasting glucose positively associated early age first childbirth early age last childbirth conclusions younger maternal age first last childbirth independently associated higher risk metabolic syndrome postmenopausal women advanced maternal age last childbirth however independent risk factor metabolic syndrome
objective aim study examine whether anti inflammatory interleukin exerts chondroprotective effects vitro model single mechanical injury mature articular cartilage method articular cartilage harvested femoro patellar groove adult cows bos taurus cultured bovine equilibration explants subjected axial unconfined compression strain velocity held cell death measured histomorphometrically nuclear blebbing release glycosaminoglycans gag dmmb assay nitric oxide griess reagent analyzed mrna levels matrix degrading enzymes nitric oxide synthetase measured quantitative real time pcr differences groups calculated using one way anova bonferroni post hoc test results injurious compression significantly increased number cells release gag nitric oxide expression mmp adamts nos administration significantly reduced injury related cell death release gag respectively expression mmp adamts nos significantly reduced conclusion joint injury complex process involving specific mechanical effects cartilage well induction inflammatory environment prevented crucial mechanisms chondrodegeneration induced injurious single compression might multipurpose drug candidate treatment cartilage related sports injuries osteoarthritis osteoarthritis research society international published elsevier ltd rights reserved
objective aim study investigate changes hedgehog expression possible effects cartilage degeneration adjuvant induced temporomandibular joint osteoarthritis tmjoa rats methods forty eight male sprague dawley rats randomly divided experimental osteoarthritis sham control groups bilateral tmjs six rats group harvested three seven days histological changes condylar cartilage assessed hematoxylin eosin toluidine blue safranin staining expression signal related proteins including indian hedgehog ihh patched ptch smoothened smo glioma associated oncogene homologue gli cartilage assessed immunohistochemistry western blot protein expression matrix metalloproteinase mmp type collagen disintegrin metalloproteinase thrombospondin motifs adamts cartilage evaluated western blot results histological analysis showed marked cartilage degeneration adjuvant induced groups including reduced cartilage cellular density thinner degraded cartilage decreased proteoglycan content extracellular matrix compared matched control groups expression ihh ptch smo gli groups higher time dependent manner protein levels mmp type collagen adamts substantially increased cartilage compared matched control rats conclusion results indicate activation ihh signaling may correlated pathological changes condylar cartilage adjuvant induced tmjoa
objective aim study test hypothesis intraoperative frozen section resection results achieve status associated different long term outcomes pancreatic cancer patients background recent data challenged survival benefit additional resection patients pancreatic cancer case positive achieve clear pathological section methods patients underwent surgery exocrine pancreatic malignancy curative intent identified prospective database data stratified resection margin group group group iii associations survival analyzed univariate multivariate analyses results total patients met inclusion criteria patients excluded due status three hundred seventeen patients allocated margin group group group iii median overall survival group iii months significant difference survival patients group whereas patients group iii significantly poorer outcome group prognostic value margin group status confirmed multivariate analysis hazard ratio confidence interval conclusions analysis intraoperative resection performed routinely patients undergoing pancreatic cancer surgery aim achieve resection
objective copper intrauterine contraceptive iuc effective method emergency contraception yet underutilized objective evaluate pilot project integrating copper iuc care study design single group evaluation study nine geographically diverse reproductive health centers implemented month pilot interventions interventions included staff education inclusion iuc patient counseling sites developed patient education materials health center staff completed manual monthly tracking forms number patients receiving oral levonorgestrel ulipristal acetate copper iuc sites also tracked reported number patients returning removal month pilot period subsequent months main study outcomes included number iuc insertions proportion day insertions proportion patients receiving type pilot period secondary outcome number patients returned removal months postpilot results iuc insertions pilot period seventy seven percent day insertions remainder returned insertion within days unprotected intercourse percentage patients choosing iuc varied site overall months postpilot patients returned removal conclusions women interested copper iuc therefore women offered option results suggest large majority continued use iuc ongoing contraception implications copper iucs viable option women need women offered effective option elsevier inc rights reserved
objective current study examined effects pharmacologic dopaminergic manipulations working memory related brain activation postmenopausal women understand neurochemistry underlying cognition menopause methods eighteen healthy postmenopausal women mean age years completed three study days dopaminergic drug challenges performed functional magnetic resonance imaging visual verbal back test working memory acute stimulation oral agonist bromocriptine acute blockade oral haloperidol matching placebo administered randomly blindly three study days results found dopaminergic stimulation increased activation primarily posterior regions working memory network compared dopaminergic blockade using whole brain cluster level corrected analysis dopaminergic medications affect working memory performance conclusions patterns increased blood oxygen level dependent signal activation dopaminergic stimulation found study posterior brain regions effect working memory performance studies examine specific dopaminergic contributions brain functioning healthy postmenopausal women determine effects increased brain activation cognition behavior
objective identification biomarker prognostic value unmet need multiple sclerosis objective study investigate possible association hla genotype disease status progression based comprehensive sensitive clinical magnetic resonance imaging mri parameters measure disease effects method total patients females males underwent hla typing patient status assessed two time points year interval based clinical scores including edss msss tfw hpt sdmt bvmt cvlt mri evaluations quantitative brain mri values obtained whole brain atrophy flair lesion volume change number new lesions using msmetrix predefined hla patient groups compared disease status progression global assessment achieved overall statistic assessment per measurement welch test mann whitney test effects multiple covariates including age gender disease duration well scan parameters also evaluated using regression analysis results hla allele associated better outcomes terms msss edss new lesion count welch test value hla hla alleles showed global negative effect disease status although none measurements reached significance value results hla drb hla dqb hla alleles inconclusive influence confounding variables statistical analysis limited elsevier rights reserved
objective interleukin cytokine family involved number chronic inflammatory diseases spite contradictory findings lack causality clinical studies inhibition systemic lupus erythematosus sle regained attention potential therapeutic pathway demonstrating disease modifying capabilities ankylosing spondylitis investigated clinical associations interleukin patients sle material methods cross sectional study performed involving sle patients age years female recruited regional registry levels determined immunoassay disease activity systemic lupus erythematosus disease activity index sledai cumulative damage systemic lupus international collaborative clinics damage index sdi scores non parametric techniques used examine association disease activity autoantibody profiles compared healthy controls principal component analysis pca used determine interplay immune cells across disease states damage development sle patients results sle patients higher igg levels lower cell cell counts median levels differ controls sle patients correlate sledai sdi inversely related age correlation coefficients systolic blood pressure years smoking cumulative heart malignancy damage serological correlations existed immunoglobulin igg levels high sensitivity reactive protein crp levels proteinuria pre albumin longitudinal data showed modest fluctuation levels independent sledai conclusion results suggest participating inflammation may also serve protective purpose sle patients
objective objective study examine association plasma estradiol testosterone risk dementia elderly men methods within population based three city study including men age years older case cohort design set years follow baseline plasma levels total beta estradiol total total testosterone total bioavailable testosterone bio measured cases incident dementia random sample cohort cox regression models used estimate multivariate steroid sex hormone associated hazard ratios confidence intervals dementia results reverse shaped relationship total risk dementia compared median tertile hrs associated total lower upper tertile increased respectively low bio associated greater risk dementia one standard deviation decreasing log bio confidence interval interaction found bio age bio education risk dementia associated low bio greater older men years older younger men younger years respectively men high level education compared low level education respectively significant association found total dementia conclusions low levels testosterone associated risk dementia elderly men association low bio dementia may relevant men years older men high level education alzheimer association rights reserved
objective objective examine naturalistic usage infotainment systems assess use characteristics patterns background infotainment systems continue evolve terms capabilities information availability raising concerns distraction potential assessing potential distraction requires understanding challenging different tasks frequently occur driving method high end infotainment system use observed across participants period approximately weeks one two different infotainment systems provided participants audio video driving performance data collected observed trained reductionists two infotainment systems integrated ipod satellite radio dvd playback one case navigation functionalities systems differed vehicle integration advanced infotainment features offered results median participant interacted infotainment systems every percentile interactions interactions involved adjusting volume although lengthy interactions median duration percentile required measurable visual involvement compared matched baseline median total eyes road time across interactions percentile differed significantly across type system interaction longer interactions tended occur vehicle stationary conclusion drivers habitually interact infotainment systems driving includes advanced functions self regulation observed application data provide comparison basis use examining driver interactions future infotainment systems
objective prompt study compared efficacy tolerability two treatment intensification strategies adding saxagliptin uptitrating metformin monotherapy patients type diabetes inadequate glycaemic control sub maximal metformin dose research design methods double blind week study metformin tolerant patients metformin monotherapy randomised receive fixed dose metformin day plus either add saxagliptin day saxa met two step metformin uptitration met maximum dose day clinical trial registration nct main outcome measures primary absolute change baseline glycated haemoglobin hba week secondary proportion patients achieving therapeutic glycaemic response week change baseline fasting plasma glucose week safety tolerability exploratory analyses comprised three patient related questionnaires including validated dimension digestive health status index dhsi results total patients randomised saxa met met baseline mean hba saxa met met adjusted mean reductions baseline hba week saxa met met mean difference treatment effect proportion patients achieving therapeutic glycaemic response hba saxa met met five dhsi domains mean differences observed diarrhoea predominant score dysmotility score saxa met met respectively common adverse event diarrhoea saxa met met conclusions metformin tolerant patients inadequately controlled sub maximal metformin monotherapy saxagliptin well tolerated although hba reduction significantly different treatment groups lower occurrence gastrointestinal symptoms saxa met group suggests saxagliptin add treatment may suitable alternative treatment strategy metformin uptitration
objective purpose study identify community pharmacist perceptions attitudes toward ethical issues community pharmacy setting saudi arabia method cross sectional descriptive qualitative survey community pharmacists conducted survey questions pre tested pharmacist extensive experience ethical issues based result pilot study questionnaire used modifications final questionnaire sent participants handing person mail email results often discuss ethical issues patients never discuss often record ethical concern whereas never reported patients initiate ethical issues discussion pharmacists initiate discussion barriers limit discussing ethical issues patients lack time due obligations assigned community pharmacist lack reliable resources interested subject lack knowledge ethical issues reasons recourses books internet web sites brochures minority respondents access computer databases resources perceived ethical problems asked hormonal contraception dispensing drug unreported indication dispensing dose medicine child outside snf limits unwanted professional behavior controlled drugs colleague insisting unethical behavior colleague done something unethical first time suspecting child abused prescribing private scripts suspected medications possible abuse terminally ill patient asks diagnosis prognosis conclusion findings study assured need saudi health authorities implement code ethics pharmacy practicing cover aspects ethical issues production hosting elsevier behalf king saud university
objective purpose study present ankylosing spondylitis patient fracture dislocation got reduction fixation successfully surgical treatment methods year old chinese male years history admitted emergency department complaining sensory motor disturbance hours due fall home fracture dislocation diagnosed personal history neurological examination ray mri results posterior cervical instrumentation fusion lateral mass screws pedicle screws meanwhile satellite rod placed disperse stress lamina ossified ligamentum flavum removed decompression extra dural hematoma observed given patient longstanding history fracture dislocation site highly unstable combined anterior posterior fixation performed patient underwent open reduction internal fixation fracture anterior cervical plating iliac crest autogenous bone grafting patient well postoperatively neurological state recovered frankel muscle strength upper extremities lower extremities although neurological improvement minor motivation increased pain neck disappeared conclusion surgical treatment patients subaxial unstable fracture dislocation performed successfully
objective purpose study identify characteristics canadian doctors chiropractic dcs associated number patients referred medical doctors mds methods secondary data analyses performed cross sectional survey canadian chiropractic resources databank canadian chiropractic resources databank survey included questions practice dcs mailed questionnaires returned meet inclusion criteria analyzed sample included respondents bivariate analyses conducted predetermined potential predictors annual number patients referred mds negative binomial multivariate regression performed results average dcs reported receiving standard deviation patient referrals mds per year nearly one third receive type clinic multidisciplinary province practice atlantic provinces number treatments provided per week number practicing hours rehabilitation sports injuries main sector activity prescription exercises use heat packs ultrasound percentage patients referred health care providers associated higher number referrals dcs percentage patients somatovisceral conditions using particular chiropractic technique hole one thompson taking radiographs client chiropractic management service considering maintenance wellness care main sector activity associated fewer referrals conclusion canadian dcs interacted health care workers focus practice musculoskeletal conditions reported referrals mds
objective purpose study measure immunohistochemically expression elf protein term human rat placentas human placentas associated gestational diabetes intrauterine growth restriction iugr methods results quantitated stereologically using stereological variable volume density semiquantitative analysis performed independently certified pathologist results total expression elf protein higher pathological pregnancies corresponding control term placentas methods quantifications showing similar results addition elf expression also higher connective tissue blood vessels chorionic villi iugr placentas placentas compared healthy controls elf higher placenta whole components pathologies two exceptions chorionic plates iugr decidua expression lower healthy controls conclusions shown iugr associated significantly increased levels elf protein placentas suggests elf may play important role normal placentation however term placentas study elf premature births would give better insight human placentation health disease
objective trait meta mood scale tmms item self assessment questionnaire developed measure perceived emotional intelligence level dimensions attention clarity repair study aimed explore psychometric properties french version instrument method instrument factor structure normality internal consistency stability concurrent validity assessed sample young adults female besides tmms participants completed self assessment questionnaires affectivity shortened beck depression inventory state trait anxiety inventory positive negative emotion scale alexithymia bermond vorst alexithymia questionnaire interpersonal functioning empathy quotient discriminant validity tested female patients anorexia nervosa identified literature difficulties introspection expression emotional regulation results confirmatory factor analysis results replicate factor structure internal consistency reliability indices adequate direction degree correlation coefficients tmms dimensions questionnaires support instrument concurrent validity tmms allows highlight differences perceived levels men women attention clarity well patients anorexia nervosa control subjects dimensions conclusion first validation study shows satisfying psychometric properties tmms french version objectif trait meta mood scale tmms est auto questionnaire items developpe pour mesurer niveau intelligence emotionnelle percue dimensions attention clarte reparation objectif cette etude etait explorer les proprietes psychometriques version francaise cet outil methode structure factorielle instrument normalite consistance interne stabilite validite concomitante ont ete evaluees dans echantillon jeunes adultes femmes plus tmms les participants ont complete des auto questionnaires affectivite shortened beck depression inventory stait trait anxiety inventory echelle emotions positives negatives alexithymie bermond vorst alexithymia questionnaire fonctionnement interpersonnel empathy quotient validite discriminante quant elle ete testee chez patientes souffrant anorexie mentale pour lesquelles litterature rapporte des difficultes introspection expression regulation emotionnelle resultats les resultats analyse factorielle confirmatoire repliquent structure facteurs les indices consistance interne fiabilite sont satisfaisants sens degre des coefficients correlation entre les dimensions tmms les autres questionnaires supportent validite concomitante instrument tmms permet mettre evidence des differences niveaux percue entre les hommes les femmes attention clarte ainsi entre des personnes souffrant anorexie mentale des temoins pour les dimensions conclusion cette premiere etude validation indique des qualites psychometriques satisfaisantes version francaise tmms
objective western desert kidney health project wdkhp innovative clinical screening arts health community development program staffed aboriginal health workers wdkhp aimed prevention early detection improving chance better management kidney disease among people predominantly aboriginal communities rural western australia paper aimed understand community responses wdkhp three communities methods interviews undertaken aboriginal people living three remote communities community responses analysed attention social organisation participants community focus perspectives key groups identified community leaders homelanders refuge seekers dislocated results participants groups reported wdkhp highly acceptable effective means drawing attention need prevention early detection management diabetes kidney disease integration aboriginal health workers explain project contributed high rates participation clinical screening conclusions outreach clinical services appropriate method engaging people remote communities addressing diabetes kidney disease implications remote community setting act enabler healthy lifestyle aboriginal people particularly augmented well designed outreach programs
objective little research short term treatments borderline personality disorder bpd core changes may occur long term treatments short term treatments may enable study early generic processes engagement therapy thus inform effective treatment components shown session version psychiatric treatment effective reducing borderline symptoms end treatment kramer kolly berthoud keller preisig caspar despland effects motive oriented therapeutic relationship ten session general psychiatric treatment borderline personality disorder randomized controlled trial psychotherapy psychosomatics also demonstrated randomized design adding motive oriented therapeutic relationship motr following individualized case formulation based plan analysis increased general outcome session positive effect early changes self esteem alliance method present study focuses follow period initial treatment examining treatment density outcomes months service utilization months outcome measured using results results sub sample patients available data follow motr treatment comparison treatment showed maintenance gains follow period differ conditions appeared sample motr treatments using number sessions lasted weeks lower treatment density defined number sessions per week compared treatments without motr density marginally predicted symptom reduction follow patients motr treatments greater likelihood entering structured psychotherapy initial sessions patients comparison group conclusions results overall consistent earlier studies short term treatments bpd underline importance individualizing interventions using case formulations rely idiographic methods integrative concepts
objective article aims investigate gender differences positive mental health among outpatients schizophrenia methods outpatients aged years schizophrenia spectrum disorders recruited tertiary psychiatric hospital administered following instruments positive mental health pmh instrument patient health questionnaire phq generalized anxiety disorder gad global assessment functioning gaf scale socio demographic clinical characteristics gathered interviews participants well medical records independent tests chi square tests performed investigate gender differences pmh total domain specific scores association socio demographic clinical characteristics pmh furthered explored men women independently using multiple linear regression analyses using backward stepwise method results pmh total score emotional support global affect sub scale scores significantly higher among women men pmh value domains value value given men women samples differ significantly socio demographic clinical profiles adjusting covariates men formal primary education significantly associated lower pmh total score higher secondary level pre university education men belonging malay ethnic group significant higher pmh total score compared men chinese ethnicity among women samples depression measured phq significantly lower scores pmh total score higher gaf score associated significantly higher scores pmh total score conclusions study identified gender differences pmh patients schizophrenia spectrum disorders whereby women higher pmh total score domain scores men study also identified factors associated pmh aid designing gender appropriate mental health interventions authors published elsevier inc open access article license
objective study aimed evaluate short long term outcomes patients severe enduring anorexia nervosa compared non nse treated via inpatient programme based recovery model approach methods sixty six adult patients anorexia nervosa recruited among consecutive referrals community based eating disorder clinic offering inpatient enhanced cognitive behavioural therapy eating disorders cbt body mass index bmi eating disorder examination ede brief symptom inventory bsi scores recorded admission end treatment month follow ups results thirty two patients classified duration illness years nse treatment groups displayed similarly large increases bmi well improvements eating disorder general psychopathology discharge minor deterioration occur nse groups showed similar rates good bmi outcome respectively full response bmi minimal eating disorder psychopathology respectively month follow conclusions findings suggest inpatient cbt well accepted patients could also viable promising treatment elsevier ltd rights reserved
objective study aimed evaluate effect health education combining diet exercise supervision menopausal symptoms diet exercise habits methods randomized controlled study enrolled patients perimenopausal syndrome kupperman menopause index kmi score participants randomized either intervention group control group women interviewed questionnaires perimenopausal symptoms diet pattern exercise habit height weight measured women intervention group received health education diet supervision exercise supervision twice week control group continued normal total kmi score scores individual symptoms diet pattern exercise habit measured intervention results total kmi score individual kmi scores paresthesia irritability depression suspicious fatigue arthralgia myalgia palpitations intervention group significantly lower compared control group intervention intake cereal meat fats oils intervention group significantly lower week compared baseline percentage women regular exercise habit significantly higher intervention group control group intervention conclusions twelve weeks intervention health education combining diet exercise supervision could improve perimenopausal symptoms help patients establish good living habits
objective study aimed investigate clinical characteristics risk factors acanthosis nigricans obese patients methods obese patients without group obese patients group included study clinical data patients collected serum levels leptin measured elisa results body mass index bmi uric acid levels fasting insulin homa higher levels leptin significantly higher adjustment bmi gender male patients showed lower serum levels testosterone multiple logistic regression analysis demonstrated leptin independent risk factors addition low testosterone level independent risk factor male obese patients conclusions associated severe hyperinsulinemia hyperuricemia obese patients well lower serum testosterone levels male patients leptin independent risk factors obese patients low testosterone may valuable predictor male obese patients
objective study aims evaluate sports recreation injuries present emergency department identify activity injury patterns associated hospital admission determine injuries could better treated alternative care settings methods retrospective review sports injuries presented emergency department high volume urban tertiary referral center identified sports term search algorithm applied emergency department records main outcome measured hospital admission status sports injury univariate multivariate regression analysis performed identify risk factors hospital admission sports injury population results encounters sports injuries admitted basketball injuries prevalent terrain vehicle atv related injuries often admitted logistic regression identified atv riding age years old independent risk factors admission basketball black race independently protective isolated sprains strains soft tissue injuries rarely required admission conclusions admission rate higher previously reported likely study institution tertiary referral center atv riding associated higher severity injuries likely require hospital admission sports injuries present emergency department specifically isolated soft tissue injuries extremities may efficiently treated non emergent setting
objective study evaluated efficacy targeted social skills training group school aged children autism spectrum disorder asd intervention seaver nett nonverbal communication emotion recognition theory mind training session cognitive behavioral intervention cbi verbal school aged children targeting asd specific social behavioral impairments method sixty nine children asd years age verbal iqs greater participated randomized comparative trial examine efficacy nett relative facilitated play group treatment outcomes included caregiver reports social behavior neuropsychological assessments social cognition conducted blinded raters outcomes collected baseline endpoint months posttreatment results significant improvements found social behavior outcomes nonverbal communication empathic responding social relations nett condition relative active control endpoint verbal moderated interaction effect social behavior higher verbal associated improvements cbi condition significant improvements found social cognitive outcomes significant group differences found month follow conducted approximately half sample conclusion data indicate targeted cbi social skills groups nett improve social communication deficits verbal school aged children asd moderating effects high verbal suggest need consider participant treatment characteristics associated outcomes future studies
objective study examined consistency self reported symptoms concussive events combat veterans reported experiencing concussive events method one hundred forty single deployed operation enduring freedom operation iraqi freedom operation new dawn combat veterans veteran health administration vha comprehensive traumatic brain injury evaluations ctbie post deployment head injury examined assess consistency self reported traumatic brain injury tbi related symptoms post traumatic stress disorder ptsd related symptoms tbi related concussive events soon deployment time vha ctbie results compared self report symptoms traumatic events time post deployment health assessment time comprehensive vha evaluation subjects reported significantly greater impairment concentration decision making memory headache sleep addition although half subjects denied ptsd symptoms post deployment approximately three quarters reported experiencing four ptsd screening symptoms near time vha ctbies latter time subjects also reported significantly tbi related concussive events well post concussive sequelae loss consciousness immediately following concussive events finally although reported level impairment severe render simplest activity doable vast majority simultaneously reported working attending college conclusions findings raise questions regarding accuracy veteran self report near distant traumatic events argue inclusion contemporaneous department defense dod records veteran assessment treatment planning
objective study examines effects parental stimulant medication treatment parent ratings parent child functioning ratings parent child functioning home setting immediately following laboratory based parent child interaction collected method participants parents along children ages years diagnosed diagnostic statistical manual mental disorders edition dsm attention deficit hyperactivity disorder adhd parents completed open label titration determine optimal dose lisdexamfetamine day completed month long double blind randomized pharmacological intervention parental adhd effects parental stimulant medication administered extended duration assessed parent ratings parent child functioning home setting immediately following laboratory parent child interaction task conducted academic mental health center data collected september june results stimulant medication versus placebo associated larger reductions parental adhd impairment executive dysfunction home setting significant benefits stimulant medication emerged measures parenting child behavior home laboratory setting parents treated stimulant medication versus placebo reported fewer adhd symptoms interaction successful pleasant several additional trends emerged showing beneficial effects stimulant medication parent child functioning conclusion parents treated stimulant medication evidenced improvements parent child functioning support use pharmacological intervention improve functioning families parent child adhd
objective study explored association stress depression multidimensional sleep problems construct sample year college students participants sample consisted students enrolled year study fall fall methods participants obesity prevention study completed surveys assessing sleep stress depression baseline months multilevel models predicting sleep problems conducted distinguish episodic chronic reports stress depression results participants primarily women white young adults age average hours sleep per night neither stress depression predictive sleep quantity however predictive sleep quality conclusions results show sleep quality rather sleep quantity may greater health concern young adults suggesting intervention programs targeting depression stress management healthy sleep patterns warranted
objective study moves beyond previous cohort studies benchmark data studying population elective spine surgery multicenter registry effort validate disprove identify novel risk factors dural tears methods retrospective cohort analysis queried multicenter registry patients degenerative spinal diagnoses undergoing elective spinal surgery multivariable logistic regression analysis interrogated independent risk factors dural tears results patients dural tear requiring repair occurred cases adjusted analysis following factors independently associated increased likelihood dural tear ankylosing spondylitis intervertebral disc disorders greater two levels combined surgical approach posterior approach anterior approach decompression fusion decompression age groups corticosteroid use preoperative platelet count conclusions multicenter study identifies novel risk factors dural tears elective spine surgery population including corticosteroids thrombocytopenia ankylosing spondylitis results analysis provide information surgeons use operative planning preoperative counseling discussing risk dural tears
objective study used candidate gene approach examine genomic variation associated pain anxiety distress children undergoing medical procedure study design children aged years catheter insertion recruited three midwestern children hospitals self report measures pain anxiety distress obtained well observed measure distress samples collected children biological parents analysis genomic variation genotyped variants known suspected association phenotypes interest analyses included child association family based transmission disequilibrium tests results genotype phenotype data available children family trios children male mean age years white non hispanic family based analysis one single nucleotide polymorphism snp interleukin ilb associated observed child distress bonferroni corrected levels significance two approached significance association high state anxiety nerve growth factor beta subunit ngfb high trait anxiety brain derived neurotrophic factor bdnf child analysis multiple snps showed nominal evidence relationships phenotypes interest bdnf cholecystokinin receptor possible relationships trait anxiety child family based analyses conclusions exploring genomic variation furthers understanding pain anxiety distress facilitates genomic screening identify children high risk procedural pain anxiety distress combined clinical observations knowledge explorations could help guide tailoring interventions limit procedure related distress identify genes pathways interest future genotype phenotype studies
objective thrombocytosis commonly observed patients solid tumors study aimed evaluate prognostic role circulating pretreatment platelet count large series patients head neck squamous cell carcinoma hnscc methods retrospectively studied patients hnscc treated single institution disease specific survival local regional distant recurrence free survival analyzed according distribution platelet count results defining platelet count cut point best predictive capacity classified patients two groups high platelet count low platelet count univariate analysis significant differences disease specific survival depending pretreatment platelet count year specific survival rates patients low high platelet count respectively according results multivariate analysis patients high count platelets tendency lower disease specific survival hazard ratio reach statistically significant differences conclusion platelet count significantly associated survival univariate analysis however multivariate analysis lost prognostic capacity limiting utility prognostic marker patients hnscc considering separately primary tumor location patients hypopharyngeal cancer high platelet count significant decrease disease specific survival elsevier ireland ltd rights reserved
objective thyroid abnormalities common obese children aim present study examine prevalence subclinical hypothyroidism determine circulating thyroid hormone concentrations correlate anthropometrics danish lean obese children adolescents methods cross sectional study included children adolescents aged years registry danish childhood obesity biobank overweight obese group consisted study participants body mass index bmi standard deviation score sds control group comprised lean children bmi sds participants characterized anthropometrics weight height waist circumference fasting serum concentrations thyroid stimulating hormone tsh free triiodothyronine free thyroxine baseline results prevalence higher among overweight obese compared lean study participants overweight obese group fasting serum tsh concentrations associated positively bmi sds waistheight ratio whtr conclusion prevalence higher among overweight obese study participants positive correlations circulating tsh whtr suggest central obesity independent overall degree obesity augments risk concurrent thyroid abnormalities children adolescents obesity
objective analyze factors affect use nonuse contraception adolescent young adults costa rica ages methods influence personal socioeconomic characteristics decision use contraception observed data collected survey national youth survey encuesta nacional juventud methodology based binary probit model selection bias correction heckman results showed age person partner stability relationship residency urban areas factors related lower probability contraception use hand female university education access information birth control stds sexually transmitted diseases frequency sexual intercourse good supportive family relationships factors related higher probability contraception use conclusions results could work guide design public policies prevent teenage pregnancies stds furthermore important highlight significance sex education teenagers families way education could beyond encouraging abstinence could motivate responsible sexual life
objective assess access copper iud post coital contraception pcc identify barriers obtaining contraceptive method study design used mystery caller approach survey primary care family planning gyn clinics nine cities identified via online search single researcher called clinics assuming role patient seeking copper iud pcc using standard script researcher collected information regarding access copper iud respondent knowledge copper iud indication pcc primary outcome availability copper iud pcc secondary outcomes included provision copper iud awareness copper iud indication use pcc offering accurate information regarding copper iud pcc fisher exact test used compare outcomes clinic type results two thirds primary care clinics family planning clinics gyn clinics offered copper iud primary care clinics however aware copper iud use pcc compared family planning clinics gyn clinics primary care gyn clinics offered copper iud pcc family planning clinics conclusion access copper iud pcc limited varies clinic type knowledge gaps exist regarding use copper iud pcc well regarding general medical guidelines copper iud placement implications majority primary care gyn clinics offer copper iud pcc half family planning clinics barriers included lack knowledge unavailability device unavailability appointment trained provider outdated iud provision protocols elsevier inc rights reserved
objective assess parents perceptions use time contrast empirical indications examine relationship reported implementation procedures perceived effectiveness methods surveyed parents preschool school age children aged months years well child visits regard awareness perception usage parents specifically surveyed regarding components empirically evaluated pertain directly underlying behavioral principles descriptive analyses group comparisons correlational analyses used characterize responses evaluate relationship administration variation perceived effectiveness results parents reported using response misbehavior large majority parents ported implementing manner counter empirical evidence parents endorsed effective varied significantly key implementation components use single warning several reported implementation practices correlated perceived effectiveness challenging child behavior example requiring child calm ending positively correlated perceived effectiveness conclusions results cement widely disseminated practice cast doubt fidelity typically implemented better methods educating parents evidence based discipline needed
objective characterize risk injury associated popular high school sports comparing relative frequency injury selected injury rates among sports well participation conditions within sport design setting cohort observational study high school athletes using surveillance protocol whereby certified athletic trainers recorded data academic years subjects players listed school varsity team rosters football wrestling baseball field hockey softball girls volleyball boys girls basketball boys girls soccer measurements injuries opportunities injury exposures recorded daily definition reportable injury used study required certified athletic trainers evaluate injured players subsequently restrict participation results football highest injury rate per athlete exposures volleyball lowest rate boys girls soccer showed larger proportion reported injuries games practices volleyball sport demonstrate higher injury rate per athlete exposures practices games injuries restricted players fewer days proportion knee injuries highest girls soccer lowest baseball among studied sports sprains strains accounted injuries except field hockey injuries requiring surgery knee conclusions inherent risk injury associated participation high school sports based nature game activities players therefore injury prevention programs place practices games preventing reinjury daily injury management critical component injury prevention program although sports injuries entirely eliminated consistent professional evaluation yearly injury patterns provide focus development evaluation injury prevention strategies
objective compare adherence lurasidone oral atypical antipsychotics among medicaid commercially insured patients schizophrenia research design methods administrative claims patients schizophrenia treated atypical antipsychotics lurasidone aripiprazole olanzapine quetiapine risperidone ziprasidone october september identified marketscan commercial medicaid databases classified first index antipsychotic patients years insurance coverage months pre months post index pre index use index drug main outcome measures medication possession ratio mpr discontinuation rate mean time discontinuation assessed post index pairwise comparisons lurasidone versus drug conducted using chi square tests student tests results medicaid mean age years female commercial mean age years female patients treated lurasidone medicaid population mpr patients treated lurasidone versus patients treated antipsychotics patients treated lurasidone exhibited lower discontinuation rate compared patients treated antipsychotics versus mean time discontinuation lurasidone significantly longer ziprasidone commercial population mpr patients treated lurasidone higher compared patients treated quetiapine ziprasidone discontinuation rate lower patients treated lurasidone compared patients treated antipsychotics except risperidone mean time discontinuation longer lurasidone antipsychotics conclusions medicaid commercial populations patients treated lurasidone demonstrated greater adherence compared patients treated atypical antipsychotics limitations using administrative claims data include potential errors inconsistencies coding lack complete clinical information
objective compare hormonal clinical responses gnrh pulsatile treatment weight recovered anorexia nervosa patients rec persistent functional hypothalamic amenorrhea patients secondary primary design retrospective observational ambulatory study setting university hospital patient forty one women rec body mass index without menses recovery secondary without eating disorders patients sha primary patients pha intervention gonadotropin releasing hormone pulsatile therapy main outcome measure baseline plasma levels changes induction cycles ovulation follicular recruitment pregnancies results rec group displayed higher basal plasma levels gnrh injection compared sha pha higher levels observed induction cycles rec compared sha pha follicular recruitment higher rec ovulation rate higher rec compared pha similar sha conclusion study showed increased gonadal status higher response pulsatile gnrh therapy persistent amenorrheic weight recovered compared causes suggests individual set point body weight allowing fully functional gonadal axis reached yet specific factors gonadal inertia rec still remain unclear
objective create guidelines focused use structured physical activity management juvenile idiopathic arthritis jia data sources systematic literature search conducted using electronic databases cochrane central register controlled trials medline ovid embase ovid physiotherapy evidence database studies related programs jia january december updated may study selection study selection completed independently reviewers studies included involved individuals aged years diagnosed jia taking part therapeutic exercise interventions effects various disease related outcomes compared control group program activity lower intensity data extraction two reviewers independently extracted information interventions comparators outcomes time period study design statistical analysis reported using cochrane collaboration methods quality included studies assessed according physiotherapy evidence database scale data synthesis five randomized controlled trials rcts fit selection criteria high quality rcts following recommendations developed pilates improving quality life pain functional ability range motion rom grade home exercise program improving quality life functional ability grade aquatic aerobic fitness decreasing number active joints grade cardio karate aerobic exercise improving rom number active joints grade conclusions ottawa panel recommends following structured exercises physical activities management jia pilates cardio karate home aquatic exercises pilates showed improvement higher number outcomes published elsevier inc behalf american congress rehabilitation medicine
objective describe functional status self rated health patients osteoarthritis primary care checking relationship level physical activity sociodemographic characteristics design study prevalence cross association setting primary care clinics participants adult patients diagnosis joint clinical records total selected took part study main measurements functional capacity womac scale self rated quality life euroqold questionnaire physical activity ipaq questionnaire number affected joints pain level sociodemographic characteristics results mean score obtained womac scale pain stiffness functional capacity scores respectively score showed linear trend compared level physical activity inactive subjects subjects moderate activity subjects intense activity multiple linear regression score womac scale well obtained self rated health status maintained association physical activity level adjusting sociodemographic variables number affected joints conclusions patients pain functional capacity affected dimensions functional status self rated health status higher active patients regardless number joints affected demographic characteristics elsevier espana
objective describe measure review evaluation process used identify new measures care coordination children behavioral health needs conducted part massachusetts children health insurance program reauthorization act quality demonstration grant method massachusetts child health quality coalition identified shortage pediatric measures care coordination behavioral health extensive literature review measure development committee applied care coordination key elements framework framework designed part grant work used modified rand delphi method conduct feasibility validity evaluation propose new candidate measures rigorous testing results thirty two measures evaluated one existing healthcare effectiveness data information set newly proposed measures met criteria feasibility reliability measures represented key elements contained framework measures need testing ensure scientific acceptability wide usability conclusion multipronged methodology used propose measures care coordination space pediatric behavioral health fill identified gaps existing measures
objective describe nature development nursing scientific production theme skin care newborns method literature search descriptive exploratory qualitative approach carried lilacs pubmed bdenf databases eleven articles selected results reading studies analysis performed six national publications five international publications seven studies qualitative approach four studies quantitative approach study allowed know care provided ways monitoring evaluation skin newborns conclusion studies care newborn skin found development studies aiming contribute preparation review protocols provide care prevent diseases newborns recommended
objective determine conditions psoriasis related psychological impairments particular social anxiety depression current study tested interplay selected factors gender age onset psoriasis cognitive affective elements body image experiences stigmatization patients subjective perceptions severity disease methods adult psoriasis patients completed appearance schemas inventory revised stigmatization scale body emotions scale beck depression inventory social anxiety questionnaire disease severity defined based body surface area bsa index results effect psoriasis social anxiety moderated age onset higher severity disease associated higher levels social anxiety patients pre adult onset psoriasis hierarchical multiple regressions revealed patients adult onset years age importance appearance one sense self worth main contributor social anxiety patients pre adult onset social anxiety strongly related experiences stigmatization moreover results indicated negative body related emotions mediated relationship severity disease depression additionally relationship severity psoriasis body image emotions moderated gender conclusions findings significantly extend previous studies confirming highlighting role age onset psoriasis psychological impairments provide insight factors contribute social anxiety group patients elsevier inc rights reserved
objective determine impact hormonal contraception markers ovarian reserve including antimullerian hormone amh antral follicle count afc design longitudinal prospective cohort setting university hospital patient young adult female cancer survivors healthy similar age women intervention none main outcome measure participants followed annually determine hormone levels transvaginal ultrasound subjects used within preceding months considered exposed linear mixed effects models used incorporate repeated measures adjust potential confounders result total women survivors control subjects average age years followed average visits years adjusting confounders amh found lower among survivors using lower among control subjects using relative risk confidence interval respectively afc lower among survivors control subjects using considering individual subject amh lower subject recently used survivors control subjects afc lower additive exposure across multiple visits associated differences amh afc conclusion amh afc significantly lower among women recent exposure amh afc interpreted caution measured setting recent hormone use american society reproductive medicine
objective estimate incidence hepatitis virus hcv seroconversion risk severe fibrosis cirrhosis hcv seroconverters among persons human immunodeficiency virus hiv infection methods analysed data persons hiv enrolled cohort study italy results incidence rate seroconversion person years overall drug users menwho sex men highest risk cumulative risk progression severe fibrosis cirrhosis years seroconversion conclusions new hcv infections rapidly progressive course population persons hiv hcv superinfection prioritized treatment anti hcv direct acting antivirals european society clinical microbiology infectious diseases published elsevier ltd rights reserved
objective estimate prevalence identify associated factors urinary incontinence climacteric women method cross sectional study stratified random sample women aged years studied enrolled family health strategy city pindamonhangaba sao paulo urinary incontinence investigated using international consultation incontinence questionnaire short form associated factors assessed based self reported questionnaire socio demographic obstetric gynecological history morbidities drug use prevalence urinary incontinence estimated confidence interval associated factors identified multiple logistic regression model performed using stata software version results women mean age years menopause married catholic declared black brown mean age menopause women years prevalence factors associated urinary loss pregnancy delivery genital prolapse stress depression obesity conclusion prevalence lower similar found similar studies factors associated genesis urinary loss pregnancy delivery genital prolapse obesity
objective evaluate association overactive bladder syndrome obs depression among older women methods one hundred sixty nine older women answered questionnaires overactive bladder oab yesavage geriatric depression scale results one hundred twenty nine participants symptoms obs oab points among obs exhibited mild severe depression significant correlation found obs depression conclusions high prevalence rate obs found older women large portion women exhibited symptoms mild severe depression
objective evaluate horizontal migration human mental foramen birth methods formalin fixed fetuses weeks gestation panoramic radiographs children aged years investigated distances mental foramen mental symphysis distances posterior border mandibular ramus mental foramen determined according development periods results results confirm mental foramen moves posterior direction development mandible conclusion horizontal location pre postnatal mental foramen changes posterior direction development progresses however prenatal mental foramen features irregular behavior postnatal mental foramen gradually migrates posteriorly regular pattern elsevier ireland ltd rights reserved
objective evaluate occurrence hypothalamic pituitary dysfunction following traumatic brain injury tbi determine effect functional improvement acute inpatient rehabilitation methods retrospective chart review identified male patients primary diagnosis tbi without skull fracture onset date within months prior admission years age older percentage individuals population abnormal hormone levels determined basis established normal reference range hormone assay functional independence measure assesses functional outcomes acute inpatient rehabilitation used examine relationship hormone levels functional improvement results hypothalamic pituitary dysfunction identified nearly men following tbi hypogonadism low testosterone levels observed patients followed low levels free low levels insulin growth factor patients hypopituitarism associated impaired functional recovery specifically functional independence measure change per day significantly lower patients low levels testosterone insulin growth factor conclusions findings suggest importance testosterone insulin growth factor activity early stages physical cognitive rehabilitation
objective evaluate perceived quality satisfaction sex education among university new mexico unm college students study design survey methods utilized year old unm freshmen sophomores graduated new mexico high school survey included questions type sex education satisfaction sex education point likert scale impact sexual decision making emailed participants results total surveys emailed returned response rate attend high school new mexico leaving surveys analytic sample comprehensive sex education received higher ratings abstinence sex education respectively students receiving comprehensive sex education abstinence education reported improved ability make decisions sexual initiation pregnancy prevention sexually transmitted infection prevention avoidance unwanted sex conclusion new mexico college students satisfied comprehensive sex education high school new mexico consider establishing state requirement corn prehensive sex education
objective evaluate prevalence systemic localized infection candida species possible association demographic clinical laboratory manifestations therapy patients rheumatic diseases taking tnf blockers methods consecutive patients rheumatic diseases receiving anti tnf agents included following risk factors four weeks prior study analyzed use antibiotics immunosuppressant drugs hospitalization invasive procedures subjects evaluated clinical complaints specific blood cultures obtained fungi blood samples collected candida spp detection polymerase chain reaction results patients rheumatoid arthritis ankylosing spondylitis juvenile idiopathic arthritis jia psoriatic arthritis conditions included average age patients years male mean disease duration years sixty four patients receiving adalimumab etanercept infliximab eighty one percent patients concomitantly taking immunosuppressant drugs time study one patient localized fungal infection vaginal candidiasis none patients included systemic candidiasis positive blood cultures fungi idcr positive candida spp peripheral blood sample conclusions first study assess prevalence invasive localized fungal disease candida significant number patients rheumatic diseases anti tnf therapy demonstrated low risk candidiasis despite high prevalence immunosuppressive drug use elsevier editora ltda
objective evaluate whether socioeconomic ses racial disparities parental perception experience medical home decreased methods used nationally representative samples children aged national surveys children health multivariable logistic regression used test associations ses income employment education race ethnicity medical home subcomponents personal doctor nurse usual source care family centered care referrals care coordination controlling priori identified covariates results fewer children overall access medical home aor confidence interval significant changes ses racial trends access medical home time period example parents children federal poverty level fpl significantly less likely report medical home parents children fpl however disparity significantly change time period aor confidence interval also significant changes ses racial ethnic disparities time medical home subcomponent conclusions despite widespread efforts promote medical home children large ses racial disparities parental perception experience medical home persisted
objective examine associations glucoregulation categories psychological resources hedonic well life satisfaction positive affect eudaimonic well personal growth purpose life ikigai interdependent well gratitude peaceful disengagement adjustment among japanese adults question important given increases rates type diabetes japan recent years combined fact prior studies linking psychological resources better physical health utilized western samples method data came midlife japan study involving randomly selected participants tokyo metropolitan area subsample completed biological data collection female age years glycosylated hemoglobin hbac outcome models adjusted age gender educational attainment smoking alcohol chronic conditions body mass index bmi use antidiabetic medication negative affect results purpose life beta associated lower hbac peaceful disengagement beta associated higher hbac fully adjusted models comparable effects bmi standard deviation change well associated change hbac conclusions associations among psychological resources glucoregulation mixed healthy glucoregulation evident among japanese adults higher levels purpose life lower levels peaceful disengagement thereby extending prior research united states results emphasize need considering sociocultural contexts psychological resources experienced order understand linkages physical health
objective examine birth weight pregnancies isolated single umbilical artery isua methods case control study retrospective review singleton pregnancies isolated single umbilical artery diagnosed birth control group consisted singleton pregnancies recruited prospectively histological confirmation vessels cord pregnancies classified uncomplicated high risk according presence diseases increase risk placental insufficiency pregnancy mean birth weight frequency low birth weight low birth weight fetal growth restriction centiles compared groups results mean birth weight difference isua control pregnancies birth weight centile significantly common isua group versus uncomplicated pregnancies considered groups birth weight differences observed amongst high risk subgroups birth weight centile remained significantly common isua compared control pregnancies versus conclusion isolated single umbilical artery increase risk fetal growth restriction uncomplicated singleton pregnancies
objective examine duration time delay wechsler memory scale wms logical memory logical memory affected participants recall performance method total logical memory administrations participants diagnosed either alzheimer disease vascular dementia vad normal cognition national alzheimer disease coordinating center uniform data set results sample administered standard min delay specified wms wms iii found significant effect delay time duration proportion information retained vad group compared control group remained adding lmi raw score covariate poorer retention information longer delay group association strong cognitively normal groups min delay optimal differentiating vad participants classification accuracy min delay optimal differentiating versus normal participants classification accuracy min delay optimal differentiating vad versus normal participants classification accuracy conclusions considering diagnostic implications findings suggest test administration incorporate precise tracking delay periods recommend min delay min range poor classification accuracy based data alone reminder story memory performance one piece data contributes complex clinical decisions however strict adherence recommended range yields optimal data diagnostic decisions
objective examine effects dietary protein obesity classification energy restriction induced changes weight body composition appetite mood cardiovascular kidney health research methods procedures forty six women ages bmi followed week kcal energy deficit diet containing higher protein protein normal protein protein retrospectively subgrouped according obesity classification pre obese pob bmi obese bmi results subjects lost weight fat mass lean body mass lbm comparable weight loss lbm losses less pob main effects protein obesity lbm changes independent additive pob lost less lbm energy restriction induced decline satiety less pronounced perceived pleasure increased decreased lipid lipoprotein profile blood pressure improved kidney function minimally changed energy restriction independently protein intake discussion consuming higher protein diet accomplishing weight loss becoming obese help women preserve lbm use higher protein diet also improves perceptions satiety pleasure energy restriction
objective examine extent local health department lhd assurance select services known promote protect health older adults associated favorable population health indicators among seniors design data california health interview survey chis linked wave national association county city health officials profile survey area resource file assess association lhd assurance senior health indicators assurance measured index services either directly provided contracted lhds cancer screening injury prevention comprehensive primary care home health care chronic disease prevention multilevel regression models estimated association lhd assurance services older adult health indicators controlling individual lhd county characteristics included key social determinants health poverty setting fifty seven california counties participants older adults age older main outcome measures colorectal cancer screening mammography healthy eating physical activity multiple falls among older adults results local health departments provided contracted median services adjusted analyses lhd assurance services generally unassociated seniors health behaviors screening falls greater lhd expenditures per capita associated significantly better mammography screening rates adjusted odds ratio aor compared jurisdictions bottom one third per capita lhd spending greater county level poverty social determinant health associated greater junk food consumption aor worse fruit vegetable consumption aor highly impoverished counties consistently bottom quartile performance across indicators conclusions lhd assurance select services known promote protect health older adults appear translate higher rates colorectal cancer screening mammography healthy eating physical activity fewer falls among seniors county level poverty strongly associated older adult health underscoring key barrier address local senior health improvement efforts
objective examine racial disparity association obesity asthma children adolescents methods study based nationally representative random digit dial sample households children less years age national survey children health study sample included children ages data body mass index bmi parental reporting asthma diagnosis potential confounders multiple logistic regression analysis performed estimate crude adjusted odds ratios stratified child race ethnicity results prevalence overweight obesity self reported asthma diagnosis study sample obese children likely asthma compared normal weight children controlling child sex child age socioeconomic status environmental tobacco smoke ets neighborhood conditions study also shows strength association varied race ethnicity stratification male non hispanic black multi racial federal poverty level ets detracting neighborhood elements also significantly associated higher odds self reported asthma diagnosis conclusion observed racial difference association bmi asthma children findings significant public health implications may help public health practitioners target children adolescents higher risk prevention intervention efforts
objective examine use antimuscarinics treating urinary incontinence older adults varying levels cognition design cross sectional setting national alzheimer coordinating center participants community dwelling men women aged older measurements clinicians staff evaluated participant dementia status annual person assessments participants informants reported medications taken weeks study visit results overall confidence interval cohort took bladder antimuscarinic participants impaired cognition likely taking antimuscarinic normal cognition rates bladder antimuscarinic use participants normal cognition mild cognitive impairment dementia participants dementia took antimuscarinics simultaneously taking medicines anticholinergic properties conclusion use bladder antimuscarinics common older adults impaired cognition normal cognition use despite guidelines advising clinicians avoid prescribing antimuscarinics individuals dementia vulnerability anticholinergic induced adverse cognitive functional effects substantial proportion cognitively impaired individuals took antimuscarinics simultaneously taking anticholinergic medications findings suggest need improve treatment individuals impaired cognition
objective examine variation long acting reversible contraception larc use source birth control services design cross sectional study setting applicable patient sexually active women received contraceptive services past months neither pregnant trying become pregnant sterilized partners sterilized intervention three multinomial logistic regression models assessed relationship source services larc use controlling covariates odds larc use compared larc nonuse high efficacy use low efficacy use main outcome measure reported larc method use result statistically significant difference larc use women receiving services community public health clinics women receiving services private clinics women receiving care family planning clinics lower odds larc use versus larc nonuse odds ratio confidence interval versus high efficacy method use versus low efficacy method use compared receiving services private clinics conclusion women receiving care family planning clinics lower odds larc use compared receiving care private doctor office health maintenance organization facility american society reproductive medicine
objective explore middle aged older veterans current disease management practices mental health treatment preferences challenges living multiple chronic health conditions multimorbidity methods semi structured qualitative interviews self report measures collected middle aged older years age older veterans multimorbidity results sample veterans multimorbidity average mildly depressed anxious elevated stress disability veterans acknowledged interaction physical emotional symptoms caused greater difficulty health care management daily functioning veterans many concerns regarding physical emotional health conditions continued disease progression addition emotional physical health complications veterans also identified specific self care approaches disease management medication healthy lifestyle practices psychological stress management techniques well barriers engaging care money transportation stigma participants preferred combination medication psychotherapy healthy lifestyle practices mental health treatment majority participants agreed mental health treatments would beneficial integrate disease management older veterans multimorbidity lastly veterans provided array recommendations improving veteran administration services reducing mental health stigma conclusions findings provide support patient centered approaches integrated mental physical health self management veteran administration middle aged older veterans multiple chronic conditions copyright john wiley sons ltd
objective identify compare treatment system factors associated survival early stage glottic cancer study design retrospective study cases commission cancer national cancer database methods adult patients early glottic cancer stage diagnosed january december included demographic tumor survival variables included analyses multivariate cox regressions well univariate kaplan meier analyses conducted results total patients included study treatment factors associated improved survival included larynx preserving surgery alone hazard ratio larynx preserving surgery radiation compared radiotherapy alone system factors associated worse survival included intermediate low volume centers medicaid medicare government insurance delay diagnosis treatment greater days conclusion number treatment system factors found significantly associated survival controlling patient tumor factors may present targets improvement outcomes early stage glottic cancers
objective investigate association increased carotid intima media thickness cimt homocysteine level mthfr gene polymorphism egyptian people rheumatoid arthritis subjects methods egyptian women patients controls included study cimt measured using high resolution mode ultrasonography homocysteine levels measured using enzyme linked immunosorbent assay mthfr polymorphism analyzed polymerase chain reaction restriction fragment length polymorphism results found subjects carried genotype allele significantly likely develop fold respectively patients carrying allele presented statistically significant increased risk developing atherosclerosis compared carrying allele moreover mthfr genotype independent risk factor thick cimt conclusions mthfr gene polymorphism associated egyptians mthfr carriers higher concentrations serum hcy subjects harboring genotypes presence allele increases risk atherosclerosis patients increased risk atherosclerosis could due hyperhomocysteinemia elsevier rights reserved
objective investigate effect operator knowing real time contact force efficacy pulmonary vein antrum isolation pvai methods fifty patients paroxysmal atrial fibrillation short lasting persistent randomized guided pvai conventional pvai guided group aimed efficacy pvai measured reduction burden afb time recurrence detected implantable cardiac monitor icm inserted three months pvai blanking period three months follow months results pulmonary veins isolated guided group one conventional group mean guided group conventional group compared pre ablation median iqr relative reduction afb months ablation guided group conventional group different groups nine patients recurrence guided group conventional group log rank test differed operators adjusted operator regression analysis patients without recurrent lower proportion ablation time recurrent patients complications occurred conclusions operator knowledge real time significant effect afb reduction time recurrence larger trials done study benefit real time
objective investigate effects light therapy serotonin transporter binding htt bpnd index htt levels anterior cingulate prefrontal cortices acc pfc winter seasonal affective disorder sad htt bpnd fluctuates seasonally greater extent sad relative health hypothesized sad htt bpnd would reduced acc pfc following light therapy methods eleven sad participants underwent dasb positron emission tomography pet scans measure htt bpnd weeks daily morning light therapy results primary finding main effect treatment htt bpnd acc pfc repeated measures manova effect significant acc magnitude decrease pfc magnitude decrease htt bpnd also decreased regions assayed following light therapy repeated measures manova including hippocampus ventral striatum dorsal putamen thalamus midbrain magnitude conclusions results demonstrate light therapy reaches important therapeutic target treatment sad provide basis improvement treatment via application dasb pet
objective investigate efficacy safety pharmacokinetics infliximab ifx japanese patients active ankylosing spondylitis methods multicenter open label study ifx infused japanese patients active using intolerable non steroidal anti inflammatory drugs nsaids weeks every six weeks approximately three years mean weeks results assessment ankylosing spondylitis asas response week primary endpoint thereafter maintained approximately three year study period improvements range motion physical function inflammatory parameters quality life qol maintained throughout three year study period serum ifx level maintained six week infusion intervals two patients developed antibodies ifx specific adverse events patients observed conclusion findings suggest administration ifx six week intervals japanese patients active safe effective provides long term therapeutic benefits
objective investigate key stakeholders consider advantages opportunities improvement using lean thinking tools integrated project delivery ipd process method detailed literature review followed case study lean ipd project interviews members project leadership team focus groups integrated team well design team online survey stakeholders conducted analysis statistical analysis thematic content analysis used analyze data followed plus delta analysis results learning large implicit benefit lean ipd currently captured success metric cardboard mock successful lean strategy although collaborative project level influence different stakeholder groups perceived different different stakeholders overall lean ipd rated better traditional design bid build methods opportunities improvement reported increase accurate cost estimating efficient use time perception imbalance control influence need facilitation represents different points view conclusion lean tools ipd method preferred traditional design bid build methods perception different stakeholders varies work needs done allow truly shared decision making model learning identified one biggest advantages
objective investigate whether individual differences coping self efficacy mediated association child abuse symptoms adhd young adults method self reported measures coping self efficacy child abuse adhd obtained adults results adults reported childhood physical sexual abuse prior age significantly higher levels adhd individual differences coping self efficacy fully mediated association child abuse adhd symptoms adulthood individuals endorsed child abuse lower coping self efficacy coping self efficacy negatively predicted adhd symptoms discussion findings suggest potential causal mechanism childhood physical sexual abuse may result adhd symptoms later life interventions improve coping skills may useful preventing later adhd symptoms among adults childhood history physical sexual abuse
objective perform systematic review literature examine original research contraception women cystic fibrosis specific focus safety efficacy non contraceptive benefits utilization patterns population study design searched pubmed embase databases peer reviewed original research english use contraception women results identified unique citations title review exclusion articles reporting original data publications included final review least two articles area focus limited evidence indicates oral contraceptive pills likely safe efficacious women hormonal contraception may reduce pulmonary exacerbation rates decrease need antibiotics suggesting non contraceptive benefits women utilize birth control similar rates general population oral contraceptive pills condoms commonly used methods conclusions data safety efficacy non contraceptive benefits hormonal contraception women scant based limited data hormonal contraception seems safe efficacious may provide noncontraceptive benefits high quality data disease specific research required better inform contraceptive decision making among women elsevier inc rights reserved
objective quantify contribution acute versus postacute care factors survival functional outcomes hip fracture design setting participants retrospective cohort study using medicare data subjects included previously ambulatory nursing home residents hospitalized hip fracture methods used logistic regression measure associations hospital nursing home factors functional survival outcomes days among patients discharged nursing facility quantified contribution hospital versus nursing home factors outcomes omega statistic results among hospitalized patients died hospitalization total discharged alive nursing home died within days died newly unable walk within days hospital characteristics consistently associated outcomes multiple nursing home characteristics predicted day outcomes including bed count chain membership performance selected quality measures nursing home factors explained times variation odds day mortality hospital factors omega hospital nursing home confidence interval times variation odds day mortality omega times variation odds day death new dependence locomotion omega conclusions nursing home factors explain larger proportion variation clinical outcomes following hip fracture hospital factors
objective systematically review quantify effectiveness eating disorder prevention interventions methods electronic databases including cochrane controlled trial register medline psychinfo embase scopus searched published randomized controlled trials prevention interventions trials prior retrieved prior reviews results one hundred twelve articles included fifty eight percent trials high risk bias findings indicated small moderate effect sizes reduction risk factors symptoms occurred three year post intervention universal prevention media literacy interventions significantly reduced shape weight concerns females confidence interval males selective prevention cognitive dissonance interventions superior control interventions reducing symptoms cognitive behavioural therapy cbt interventions largest effect size dieting outcome month follow healthy weight intervention reduced risk factors body mass index indicated prevention interventions found effective reducing risk factors conclusions number promising preventive interventions risk factors including cbt whether actually lower incidence however uncertain combined obesity prevention interventions require research elsevier ltd rights reserved
objective understand women anticipate difference reproductive healthcare attending catholic institution study design convenience sample reproductive aged women denver metro area completed online survey women randomized hypothetical women health clinics either secular catholic hospital asked expectations family planning care questions covered contraception management abnormal unintended pregnancy subsequently assessed provider site preferences care results analyzed surveys majority participants expected gynecologist provide family planning services presented difference based institution participants randomized catholic hospital likely expect natural family planning advice least half respondents reported would seek care gynecologist services surveyed exceptions emergency contraception elective abortion conclusions overall cohort women anticipate differences reproductive healthcare based institution women enroll catholic hospitals receive information related potential healthcare restrictions ability act informed healthcare consumers may constrained elsevier inc rights reserved
objective validate published diagnostic models ability safely reduce unnecessary endoscopy referrals primary care patients suspected significant colorectal disease study design setting following systematic literature search independently validated identified diagnostic models cross sectional study dutch primary care patients persistent lower abdominal complaints referred endoscopy estimated diagnostic accuracy measures colorectal cancer significant colorectal disease including colorectal cancer inftammatory bowel disease diverticulitis adenomas results evaluated models specific colorectal cancer able safely rule colorectal cancer best model national institute health care excellence prevented referrals confidence interval sensitivity negative predictive value npv area receiver operating characteristics curve auc models performed less significant colorectal disease best model brazer prevented referrals sensitivity npv auc conclusion models safely excluded colorectal cancer many primary care patients lower gastrointestinal complaints referred endoscopy models performed less well significant colorectal disease elsevier inc rights reserved
objective traditionally urodynamic studies uds used assess lower urinary tract symptoms luts routine use discouraged urodynamic stress incontinence strongly associated symptom stress urinary incontinence sui positive cough test weak relationship symptoms overactive bladder detrusor overactivity aim study develop model predict women luts study design prospective study included consecutive women luts attending urodynamic clinic women underwent comprehensive clinical urodynamic assessment effect variable odds estimated univariate analysis adjusted analysis using logistic regression results women luts included study patients diagnosed factors considered best predictors urgency urinary incontinence urge rating void parity value scores previous continence surgery scores presence sui scores complaint vaginal bulging scores criterion absent score total score vary value receiver operating characteristic roc analysis overall cut points revealed area curve conclusion model able predict accurately symptomatic diagnosis alone women luts introduction scoring system screening tool clinical practice may reduce need expensive invasive tests diagnose replace uds completely elsevier ireland ltd rights reserved
objective vascular calcification consequence complex interaction genetic environmental vascular factors ultimately lead deposition calcium tunica intima atherosclerotic calcification tunica media mdnckenberg sclerosis vascular calcification also closely related pathologies diabetes mellitus dyslipidemia chronic kidney disease concluded degree vascular calcification may vary person person even associated pathologies environmental factors therefore suggests important genetic contribution development vascular calcification review aimed find recent evidence vascular calcification pathophysiology regarding genetic aspects molecular pathways data sources conducted exhaustive search scopus ebsco pubmed keywords genetics vascular calcification molecular pathways genetic vascular calcification included main articles january august focused recent evidence vascular calcification pathophysiology regarding genetic aspects molecular pathways study selection valuable published original review articles related objective selected results vascular calcification multifactorial disease thus pathophysiology explained single specific factor rather result association several genetic variants molecular pathway interactions environmental factors promote development conclusion although several molecular aspects mechanism elucidated still need better understanding factors predispose disease
objective compared dose distributions postoperative plans preoperative plans printing template assisted radioactive seed implantations methods total patients malignant tumors enrolled study dose parameters included minimum peripheral dose statistical method paired test results significant difference values two groups parameters except conclusions printing guide template provide good accuracy radioactive seed implantation
objective conducted randomized controlled trial determine whether iriss intervention recently informed seropositive status positive affect skills intervention improved positive emotion psychological health physical health health behaviors people newly diagnosed hiv method one hundred fifty nine participants received hiv diagnosis past months randomized session person individually delivered positive affect skills intervention attention matched control condition results primary outcome past day positive affect group difference change baseline time reach statistical significance planned secondary analyses within assessment point showed intervention led higher levels past day positive affect months postdiagnosis compared attention control antidepressant use group difference change baseline statistically significant baseline months difference change time intrusive avoidant thoughts related hiv also statistically significant contrary findings health behavior interventions effects wane follow period effect sizes iriss seemed increase time outcomes conclusions comparatively brief positive affect skills intervention achieved modest improvements psychological health may potential support adjustment new hiv diagnosis
objective examined association older adults mealtime interactions senior centers shanghai life satisfaction competing hypotheses derived socioemotional selectivity theory activity theory tested method data obtained shanghai senior center service utilization survey relationships respondents mealtime interactions life satisfaction tested using multilevel regression modeling results adjusting demographics interactions tablemates companionship self disclosure instrumental support positively associated respondents life satisfaction associations varied senior centers however number tablemates significantly associated respondents life satisfaction discussion findings support activity theory based hypothesis mealtime interactions related older adults life satisfaction independent number tablemates study illuminates value social interactions context community dining programs rapidly increasing older population urban china
objective examined association utilization care dental problem utilization parent reported dental problem urgency among children type health care insurance coverage methods used weighted national health interview survey data children aged years least one within months preceding survey explanatory variables selected based andersen model healthcare utilization need considered urgent included toothache bleeding gums broken missing teeth broken missing filling decayed teeth otherwise non urgent primary enabling variable insurance four categories none private health dental coverage phnd private health dental phd medicaid state children health insurance program schip predisposing variables included sociodemographic characteristics used bivariate multivariate analyses identify explanatory variables association utilization using logistic regression obtained adjusted estimates utilization urgency insurance category results bivariate analyses utilization associated insurance urgency multivariate analyses difference percent utilizing care urgent versus non urgent among children covered medicaid schip percentage points phd percentage points phnd percentage points insurance percentage points difference utilization urgency higher children medicaid schip compared either phnd uninsured children conclusion expansion medicaid schip may permit children receive care urgent dps otherwise may due lack dental insurance
objective investigated ability bone marrow derived mesenchymal stem cells bmscs overexpressing microrna mir repair cardiac damage induced anthracyclines rats methods sprague dawley rats similar weeks old selected isolate culture bmscs lentivirus harboring plvx mir generated transfected rat bmscs rats assigned untreated negative control group groups injected adriamycin alone adriamycin followed bmscs plvx bmscs plvx mir bmscs proliferation migration cells detected cholecystokinin cck transwell mir expression mrna expressions cell lymphoma bcl bax bcl associated protein vascular endothelial growth factor vegf tested qrt pcr western blotting applied detect protein expressions bcl bax vegf results using cck transwell assays found plvx mir bmscs overexpressed mir exhibited greater proliferation migration untransfected bmscs plvx bmscs ultrasonic cardiograms immunohistochemical analysis demonstrated among five groups plvxmir bmsc group exhibited improved heart function enhanced angiogenesis moreover plvx mir bmsc group showed enhanced expression bcl vegf reduced expression bax bnp troponin conclusion findings suggest mir overexpression enhanced proliferation invasiveness differentiation bmscs well expression key factors bcl vegf bax essential repairing cardiac damage induced anthracyclines restoring heart function
objective investigated clinicopathological characteristics immunophenotype female genital system diffuse large cell lymphoma dlbcl order improve diagnosis therapy efficacy patients methods clinicopathologic features cases primary dlbcl female genital system studied retrospectively according immunophenotypes cases classified germinal center cell like dlbcl non center cell like dlbcl results immunohistochemistry data showed pax cda tested positive cdro tested negative cases cases ema positive cases positive cases bcl positive cases mum tested positive one case index less cases index remaining cases median patients underwent hysterectomy hysterectomy followed chemotherapy survival time months conclusions primary diffuse large cell lymphoma primary female genital system rare highly invasive condition easily misdiagnosed complete diagnosis important treatment prognosis vary different histological types moreover immunohistochemistry useful diagnostic method type cancer
objective data drawn beijing new rural cooperative medical system nrcms rule characteristics disease risks mined terms risk factors risk measurements aiming discover valuable knowledge within vast amounts beijing nrcms data provide administrators scientific basis decision making methodology association rule algorithm utilized recover potentially valuable knowledge decision making information beijing nrcms data results main objects healthcare beijing include circulatory diseases patients years age older pediatric respiratory disease prevention reproductive healthcare women childbearing age prevention treatment diabetes female patients county level hospitals relatively low average level consumption injuries still resulted high expenses primary post nrcms reimbursement level level high risk groups patients years age conclusion according ranking rule supports highest support rule beijing circulatory diseases middle aged patients especially patients hospitalized county level medical institutions second highest support comes utilization fertility services women childbearing age suggestions recommended rule support rankings combined actively implement emphasis major prevention healthcare services lower disease risk factors control nrcms reimbursement costs promote sustainable development nrcms adopt classified management mined rules establish decision making knowledge base
objective aim assessing response treatment conventional disease modifying anti rheumatic drugs dmards used patients psoriatic arthritis psa data methotrexate sulfasalazine ssz leflunomide analyzed baseline subsequent follow questionnaires completed patients either psa spondyloarthritides spas material methods single center real life retrospective analysis performed obtaining clinical data via questionnaires administered treatment indices used erythrocyte sedimentation rate esr reactive protein crp level bath ankylosing spondylitis disease activity index basdai bath ankylosing spondylitis function index basfi wellbeing treatment effect txe indices measured baseline compared measured one occasion visit least year later results total patients psa mean age years male female ratio spas mean age years studied basdai basfi displayed consistent improvements assessments psa patients controls comparison baseline values ssz exhibited better efficacy confirmed txe psa patients controls esr crp displayed differences either psa spa group cases treatment conclusion real life retrospective analysis three dmards used psa spas psa demonstrated three dmards used brought improvements basdai basfi txe however greatest improvements seen ssz use psa control cohorts
objective women risk obstructive sleep apnea osa increases substantially menopausal transition depression risk also elevated raising possibility estrogen withdrawal contributes osa vulnerability turn contributing mood disturbance examined association estradiol levels osa depressed peri postmenopausal women methods thirty depressed peri postmenopausal women mean body mass index bmi without known osa completed routine polysomnography concurrent serum estradiol levels estradiol women apnea hypopnea indices ahi indicating moderate severe osa compared ahi less using logistic regression adjusting age bmi results thirteen women ahi median ahi estradiol levels lower osa median interquartile range without osa median interquartile range univariate analysis higher estradiol associated reduced odds osa odds ratio adjusting age bmi estradiol levels remained associated lower odds osa odds ratio association longer statistically significant montgomery asberg depression rating scale scores differ without osa conclusions preliminary results suggest addition higher bmi age lower estradiol may associated increased osa risk depressed women peri postmenopause raising possibility estradiol withdrawal associated menopause influences upper airway patency women
objective young breast cancer patients receiving chemotherapy risk chemotherapy induced menopause cim sought define incidence rate premature menopause chemotherapy retrospectively investigate factors related onset menopause methods identified patients received chemotherapy cancer center centre jean perrin selected premenopausal women aged years moment diagnosis received chemotherapy results selected patients median age years interquartile range cim defined amenorrhea least years following end chemotherapy total premenopausal women versus menopausal women included among menopausal women cim group rate increased group women aged years diagnosis early hot flushes conclusion cim occurred patients chemotherapy age years early hot flushes significantly associated risk cim suggest definition cim standardized literature amenorrhea least years seems good cutoff although patients recovered menstrual cycles beyond limit karger basel
objective primary objective study purports develop guidelines better care children autism spectrum disorder asd particularly regarding children preparation anesthesia radiologic procedures methods using delphi method online distribution questionnaire guidelines caring children asd created twenty one participants included expert panel participants working children asd several anesthesia radiology departments sweden list items created previous survey literature first round items agreement discarded items merged new list created two similar rounds performed last rounds participants responded agreement considered consensus results final guidelines consisted items checklist factors areas covered items checklist follows planning involving parents guardians features environment use time communication health care professionals organization important making possible health care professional care individual child according child needs important involve parents guardians obtain knowledge functioning child conclusion caring encounter involving child asd anesthesia radiology contexts requires advance planning catered specifically individual needs child accomplish general knowledge regarding asd asd particular manifestation child entrusted care required health care workers organization needs structures place facilitate process
objective neurodevelopmental concerns males sex chromosome aneuploidy sca xxy klinefelter syndrome xyy xxyy include symptoms seen autism spectrum disorder asd language impairments social difficulties aimed evaluate asd characteristics research cohorts sca males dsm compared dsm criteria analyze factors associated asd diagnoses sca methods evaluation participants xxy xyy xxyy included medical history cognitive adaptive testing social communication questionnaire social responsiveness scale autism diagnostic observation schedule autism diagnostic interview revised dsm asd criteria clinical impressions asd diagnostic category using ados dsm criteria compared ados dsm criteria tests compared cognitive adaptive ses prenatal postnatal diagnoses asd asd groups results asd rates research cohorts xxy xyy xxyy using ados dsm statistically different compared dsm criteria xyy xxyy asd group lower verbal adaptive functioning compared without asd many children without asd still showed social difficulties conclusion asd rates males sca higher reported general population males chromosome aneuploidy xyy xxyy times likely diagnosis asd xxy group times likely males general population males cdc asd considered evaluating social difficulties sca studies sca chromosome genes may provide insight male predominance idiopathic asd
objective pressing need drug development pediatric crohn disease aim provide strategic approaches toward harmonization current thinking clinical outcome assessments coas biomarkers facilitate drug development pediatric methods scientists united states food drug administration european medicines agency health canada pharmaceuticals medical devices agency japan monthly teleconferences january may literature review conducted assess measurement properties existing coa tools evaluate current landscape biomarkers used pediatric based findings literature review reached consensus strategic approaches evaluating outcomes pediatric trials results pediatric crohn disease activity index crohn disease activity index harvey bradshaw index used pediatric clinical studies lack adequate measurement properties validity reliability ability detect change treatment required support approval products intended treat pediatric biomarkers fecal lactoferrin osteoprotegerin calprotectin shown promise potential noninvasive surrogate endpoints conclusions lack well defined reliable coas presents hurdle global drug development pediatric essential develop well defined reliable coas measure meaningful clinical benefit patients terms feel function survive development noninvasive biomarkers reliable surrogate endpoints needs explored
objective study examined associations among child sleep disturbances family functioning asthma controller medication adherence school age children persistent asthma methods thirty four children aged years parent independently reported asthma control controller medication adherence parents also reported family functioning behavior control child sleep disturbances bedtime resistance daytime sleepiness hierarchical linear regression models tested sleep disturbance variables predictors family functioning medication adherence mediation model tested behavior control mediator sleep disturbance medication adherence results seventy nine percent children well controlled asthma despite mean hours child sleep per night children clinically significant disturbed sleep controlling child age bedtime resistance accounted variance family behavior control behavior control also significantly mediated relationship total sleep disturbance medication adherence standardized indirect effect confidence interval parent reported adherence child reported adherence conclusion child behavioral sleep disturbances significantly predicted family behavior control although child sleep disturbances significantly predict asthma controller medication adherence significant indirect effect sleep disturbance medication adherence compromised family behavior control developmentally appropriate behavioral sleep interventions may improve family functioning child asthma controller medication adherence family functioning may also entry point intervention improve medication adherence
objective compare head trunk acceleration transport medical utility vehicles design within subject setting controlled laboratory participants nineteen male volunteers years interventions participants secured spineboard stretcher husqvarna huv dxl ambulance huv modified john deere gator gator driven synthetic field turf transitioning concrete slab interval concrete slab transitioning natural grass interval three dimensional accelerometers recorded head trunk acceleration data point acceleration trunk subtracted acceleration head peak acceleration difference determined independent variables vehicle huv gator interval interval interval main outcome measures average peak acceleration differences directions analyzed using factor within analysis variance results gator interval greater huv interval huv gator interval huv interval greater huv gator interval gator interval greater huv interval huv gator interval huv interval greater huv gator interval gator interval greater huv interval conclusions varying head trunk accelerations exist healthy spine boarded participants transport medical utility vehicles dependent surface vehicle type
objective develop validate concise survey identify athletes possess elevated injury risk design cohort study setting national collegiate athletic association division athletic program participants cohorts college athletes participated successive academic years assessment risk factors first cohort provided responses joint specific outcome surveys related subsequent time loss injury occurrence receiver operating characteristic analysis identified survey items provided best discrimination combined negative life event stress item create new item survey second cohort provided responses new survey converted score main outcome measures construct validity assessed documentation time loss injuries sustained preceding months predictive validity assessed prospective documentation sport related sprains strains cronbach alpha calculated assess internal consistency results outcome survey items used develop new survey demonstrated much greater specificity sensitivity retrospective prospective receiver operating characteristic roc analyses identified scores cut points provided good discrimination injured noninjured cases area curve retrospective analysis prospective analysis cronbach alpha conclusions self reported effects previous injury may one method efficiently identify athletes possess elevated injury risk subsequently deliver preventive interventions thereby providing alternative method time intensive functional testing
objectivebehavioral studies shown anorexia nervosa associated attentional bias general threat cues neurobiological underpinnings attentional bias threat unknown study investigated neural responses associated threat detection attentional bias threat methodswe measured neural responses dot probe task involving pairs angry neutral face stimuli adult women recovered comparison women resultsrecovered women exhibit behavioral attentional bias threat response angry faces recovered women showed significant hypoactivation extrastriate cortex attentional bias angry faces recovered women showed significant hyperactivation medial prefrontal cortex significant deactivation comparison women absent recovered women conclusionswomen recovered characterized altered neural responses threat cues copyright john wiley sons ltd eating disorders association
objectivebright light therapy widely used treatment choice seasonal affective disorder nonetheless understanding mechanisms bright light limited important investigate mechanisms purpose study examine hypothesis bright light exposure may increase fluorodeoxyglucose fdg uptake olfactory bulb hippocampus may associated neurogenesis human brain methoda randomized controlled trial comparing day bright light exposure environmental light bright light exposure group environmental light alone intervention group performed participants university hospital uptake fdg olfactory bulb hippocampus using fdg positron emission tomography compared two groups resultsthere significant increase uptake right left olfactory bulb bright light exposure group intervention group adjustment log transformed illuminance remained significant increase uptake right olfactory bulb conclusionthe present findings suggest possibility day bright light exposure may increase fdg right olfactory bulb human brain suggesting possibility neurogenesis studies warranted directly confirm possibility
objectivebulimia nervosa binge eating disorder bed associated significant health impairment premenstrual syndrome pms premenstrual dysphoric disorder pmdd comprise psychological disturbances mood affect physiological bloating changes appetite symptoms may trigger binge eating purging methodfemale participants drawn collaborative psychiatric epidemiological surveys conducted weighted multivariable logistic regression modeled association lifetime pms pmdd lifetime odds bed resultsamong participants bed additionally pmdd pms prevalence pmdd pms among among bed among subthreshold bed adjustment age race ethnicity income education body mass index age menarche birth control use comorbid mental health conditions pmdd associated seven times odds pms two times odds neither pmdd pms significantly associated bed discussionwomen pms pmdd higher odds independent comorbid mental health conditions pms pmdd may important comorbidities consider clinical settings future research investigate whether pms pmdd affect onset duration bulimic symptoms well potential shared risk factors across disorders wiley periodicals inc int eat disord
objectiveclinical supervision fundamental training psychologists neuropsychology recognised distinct discipline psychology area endorsement however specific training supervision received limited attention reflective practice supervisor competency required psychology board australia pba one element foundational competencies reflective practice described process consciously analysing decision making drawing upon theory experience order improve clinical practice discussion paper aims improve supervision neuropsychologists australia providing explicit framework incorporate reflective practice supervision methodas discussion paper first stage review supervision literature second provide practical supervision framework integrate reflective practice accordance current research specific requirements pba resultsthe extant literature supervision exceedingly limited supervision training frameworks based upon developmental competency based models indicate reflective practice core element practical framework implementation reflective practice effectively developed conclusionsthe reflective approach allows supervisees attain core functional foundational neuropsychological competencies flexible allow different contexts potentially new supervision training requirements importantly reflective practice framework supports ongoing professional development competency throughout neuropsychologists professional career span
objectiveelectroconvulsive therapy ect remains underutilized fears cognitive medical risks including risk death study aimed assess mortality rate ect means systematic review pooled analysis methodthe study conducted adherence preferred reporting items systematic reviews meta analyses prisma guideline ect related mortality rate calculated total number ect related deaths reported included studies divided total number ect treatments resultsfifteen studies data countries reporting total ect treatments met inclusion criteria sixteen cases ect related death reported included studies yielding ect related mortality rate per treatments nine studies published covering treatments one reported ect related death conclusionthe ect related mortality rate estimated per treatments comparison recent analysis mortality general anesthesia relation surgical procedures reported mortality rate per findings document death caused ect extremely rare event
objectivepoland restrictive abortion law emergency contraception expensive available prescription easily obtainable public health care aimed identify main reasons requests observed failure rates type incidence adverse effects designprospective single center observational study populationa cohort women living warsaw requested methodsdata collected via questionnaire completed healthcare providers prescribing included age date request previous use time intercourse clinic visit day menstrual cycle intercourse took place main outcome measuresreason request time lapse unprotected intercourse use age women requesting reported cases pregnancy resultsa total women requested years old follow individuals became pregnant adverse effects hormonal rare mild main reason requesting problems associated condoms mean interval unprotected intercourse use failed considering intake within difference significant conclusionswomen living warsaw seeking used product soon unprotected intercourse probably one important reasons low pregnancy rates studied population
objectivequinoa chenopodium quinoa willd seed crop rich bioactive compounds including phytoecdysones especially hydroxyecdysone polyphenols proteins essential fatty acids previously reported method leach concentrate quinoa bioactives complex phytochemical mixture termed quinoa leachate aimed determine effect chemically distinct fractions five biochemical endpoints relevant skin care applications cell viability matrix metalloproteinase mmp mrna expression iii mmp enzymatic activity tyrosinase enzymatic activity intracellular reactive oxygen species ros production methodsquinoa leachate fractionated chemically characterized using column chromatography liquid chromatography mass spectrometry cell viability determined using mtt assay four mammalian cell lines mmp mrna expression assessed human dermal fibroblasts hdf via qrt pcr enzymatic activity mmp tyrosinase measured using fluorometric colorimetric vitro assays respectively lipopolysaccharide lps induced ros production determined human dermal fibroblasts fluorescence intensity oxidant sensitive probe resultsquinoa leachate separated three fractions carbohydrate rich fraction phytoecdysone polyphenol protein rich fraction iii oil rich fraction reduce cell viability four cell lines tested significantly inhibited mmp mrna expression hdf concentration gml also significantly inhibited mmp enzymatic activity whereas demonstrated significant tyrosinase enzymatic inhibition furthermore significantly inhibited intracellular ros production conclusionthis study first demonstrate mmp tyrosinase ros inhibiting properties multiple different phytochemical components derived quinoa seeds work indicates quinoa phytochemicals may play role treatment prevention skin ageing multiplicity effects
objectives current guidelines early management patients acute ischemic stroke recommend completion evaluation within min patient arrival emergency department prolongation length stay los may reduce efficacy acute stroke treatment aim evaluate los eds community based polish stroke centers determine logistic social epidemiological clinical factors responsible prolongation assess association increased los implementation cerebral intravenous thrombolysis materials methods study carried evaluation medical records patients stroke transient ischemic attack consecutively reported pomeranian stroke registry results median los studied cohort min prolonged min patients prolongation los contributed low thrombolysis rate functional status discharge worse patients prolonged versus nonprolonged los modified rankin scale points multivariate analysis showed onset door time min unknown time symptoms onset referral urban areas living alone presence diabetes motor sensory visual gait deficits stroke onset nihss score admission contributed toward prolongation los conclusion prolonged los ineffective prehospital logistics urban location patients risk factors cohabitation profile stroke symptoms severity commonly exists among patients stroke transient ischemic attack contributes toward low rate thrombolysis polish community hospitals copyright wolters kluwer health inc rights reserved
objectives little known consequences adolescent social media use current study estimated association amount time adolescents spend social media risk episodic heavy drinking methods school based self report cross sectional study including norwegian middle high school students boys measures frequency quantity social media use frequency drinking four six girls boys respectively alcoholic drinks single day episodic heavy drinking macarthur scale subjective social status barratt impulsiveness scale brief brief sensation seeking scale patient health questionnaire items adolescents strengths difficulties questionnaire peer relationship problems scale gender school grade results greater amount time spent social media associated greater likelihood episodic heavy drinking among adolescents even adjusting school grade impulsivity sensation seeking symptoms depression peer relationship problems conclusion results current study indicate time spent social media related greater likelihood episodic heavy drinking among adolescents
objectives goal estimate diagnostic accuracy substantia nigra fractional anisotropy parkinson disease diagnosis sample similar clinical setting including patients essential tremor healthy controls also performed systematic review meta analysis estimate mean change induced diagnostic accuracy methods sample consisted subjects address inter scanner variability two mri scans performed mri results sample pooled meta analysis included subjects bivariate model used evaluate diagnostic accuracy measures results sample observe significant effect disease uninformative diagnosis results meta analysis estimated decrease mean relative however discriminatory capability diagnose low pooled sensitivity specificity respectively high heterogeneity studies conclusions facannot used isolatedmeasure diagnose
objectives patients common mental disorders cmds often suffer comorbidities may limit functioning work assessed longitudinal impact multimorbidity defined two occurring chronic health conditions work functioning time among workers returned work sick leave due cmds methods prospective cohort study workers followed year return work sick leave due cmds multimorbidity score computed counting severity weighted chronic health conditions measured baseline work functioning measured baseline months follow work role functioning questionnaire work functioning trajectories course work functioning return work time identified latent class growth analysis results total workers multimorbidity four work functioning trajectories identified one workers showed increasing work functioning scores follow whereas trajectories showed low medium high scores respectively remained stable across time points although multimorbidity predict membership trajectory within increasing score trajectory levels work functioning lower among high baseline multimorbidity score conclusions time multimorbidity negatively impacts work functioning return work sick leave due cmds
objectives perfluorooctane sulfonate pfos perfluorooctanoate pfoa widely used industrial products persistent organic pollutants due chemical stability previous studies suggested pfos pfoa might disrupt thyroid hormone status although plays important role fetal growth pregnancy little attention paid relationships maternal exposure perfluorocarbons statuses mothers fetuses investigated effects low levels environmental pfos pfoa thyroid function mothers infants methods eligible subjects prospective cohort mother infant pairs selected concentration maternal serum pfos pfoa measured samples taken second third trimesters within week delivery blood samples measuring thyroid stimulating hormone tsh free thyroxine levels obtained mothers early gestational stage median weeks infants days age respectively results median concentrations pfos pfoa confidence interval limitation detection respectively maternal pfos levels inversely correlated maternal serum tsh positively associated infant serum tsh whereas maternal pfoa showed significant relationship tsh among mothers infants conclusions findings suggest pfos may independently affect secretion balances maternal infant tsh even low levels environmental exposure
objectives prenatal development brain characterized gestational age specific changes laminar structure brain parenchyma gestational weeks cerebral lamination patterns normal fetal brain development described histologically postmortem vitro magnetic resonance imaging mri vivo fetal mri purpose study evaluate sonographic appearance laminar organization cerebral wall normal abnormal brain development methods retrospective study ultrasound findings normal fetuses fetuses abnormal cerebral lamination patterns gestational age weeks gestation investigated visibility subplate zone relative intermediate zone correlated characteristic sonographic findings cerebral lamination gestational age order evaluate transient structures results normal cohort subplate zoneintermediate zone interface identified early weeks fetuses examined weeks fetuses subplate zone appeared anechoic intermediate zone appeared homogeneously echogenic subplate zone fetuses weeks transition period lamination disappeared variable fashion subplate zoneintermediate zone interface identified fetus weeks three patterns abnormal cerebral lamination normal laminar pattern weeks association severe ventriculomegaly diffuse ischemia microcephaly teratogen exposure lissencephaly focal disruption lamination weeks associated hemorrhage porencephaly stroke migrational abnormalities thanatophoric dysplasia meningomyelocele encephalocele increased prominence echogenicity intermediate zone weeks persistence laminar pattern beyond weeks associated type lissencephaly cmv infection mixed focal diffuse pattern two fetuses cmv infection earliest indication infection focal heterogeneity increased echogenicity intermediate zone predated development microcephaly ventriculomegaly intracranial calcification conclusions fetal subplate intermediate zones demonstrated reliably routine sonography weeks disappear weeks findings represent normal gestational age dependent transient laminar patterns cerebral development consistent histological studies abnormal fetal cerebral lamination patterns gestational age also visible sonography may indicate abnormal brain development copyright isuog published john wiley sons ltd
objectives skin disease one major components health problems soldiers either war peacetime despite increased numbers scale military missions dermatological survey limited aim study outline dermatological profile international peacekeepers lebanon explore features disease pattern methods dermatological records peacekeepers visiting chinese level hospital year period retrospectively assessed comparisons previous reports skin disease military personnel performed results total patients men mean age years included half asian dermatitis eczema leading category tinea pedis lichen simplex chronicus unspecified dermatitis verruca vulgaris alopecia areata top five complaints dermatitis eczematous eruptions appeared common condition troops deployed middle east whereas fungal infection highly prevalent tropical regions additionally remarkably high rate alopecia areata noted two studies including conclusions environment group living occupational activities work related stress act initiating aggravating factors development spread conditions knowledge disease profile empowers doctors enforce preventive measures prepare treatment modalities particular underlying psychological component lichen simplex chronicus alopecia areata addressed appropriately
objectives sleep problems deprivation common pregnancy particularly third trimester previous studies mostly descriptive focused specific clinical groups late pregnancy aimed identify sleep duration trajectories pregnancy period associated factors impact pregnancy birth outcomes methods studied women mother child cohort recruited french general population used semi parametric models analyze data collected questionnaires results detected three sleep duration trajectories pregnancy short decreasing night trajectories factors associated short decreasing trajectory relative medium decreasing trajectory older age odds ratio year confidence interval working weeks gestational age odds ratio sleep duration pregnancy trajectory group modified insomniac symptoms regression coefficient trimester standard error naps regression coefficient trimester restless legs syndrome factor associated long increasing trajectory decreased sleep duration regression coefficient trimester assisted delivery cesarean section instrumental delivery post partum depression frequent among women short decreasing long increasing trajectories whereas cesarean section alone prevalent among short decreasing trajectory proportion premature births higher short decreasing trajectory group birth weight score lower long increasing trajectory group conclusion identified sleep trajectories among pregnant women specific risk factors could affect pregnancy birth outcomes taking consideration could improve maternal child health
objectives takotsubo cardiomyopathy ttc acute cardiac syndrome simulating myocardial infarction characterized transient wall motion abnormalities absence coronary artery obstruction reverse ttc rttc recently described variant ttc review defines compares forms ttc stating resemblances differences methods conducted search medline database forty one cases rttc met eligibility criteria summarized synthesis demographic features clinical characteristics laboratory studies results patients studied women patients ages ranged years mean age predominant electrocardiogram finding segment depression whereas segment elevation present patients troponin levels raised patients mean troponin patients wall motion abnormalities echocardiography mean ejection fraction patients documented angiography normal coronaries minor mild obstructive coronary artery disease patients died mean recovery time ejection fraction survivors days conclusions rttc distinct presentation classic ttc remarkable differences exist forms terms mean age sex electrocardiogram presentation troponin levels mortality
objectives sphenopalatine ganglion spg plays pivotal role cluster headache pathophysiology major efferent parasympathetic relay evaluated long term effectiveness spg stimulation medically refractory chronic patients methods thirty three patients enrolled open label follow study original pathway study participated months post insertion microstimulator response therapy defined acute effectiveness attacks reduction attack frequency versus baseline results total attacks range per patient evaluated months patients acute responders among acute responders total attacks treated effective therapy achieved using spg stimulation relief moderate greater pain freedom mild pain greater frequency response observed patients mean reduction attack frequency versus baseline total patients either acute frequency responders majority maintained therapeutic response month evaluation conclusions population disabled medically refractory chronic patients treated study spg stimulation effective acute therapy patients offering sustained effectiveness months observation addition maintained clinically relevant reduction attack frequency observed third patients long term data provide support use spg stimulation disabled patients considered medical treatments fail tolerated inconvenient patients
objectives paper highlights lessons introductory efforts presents new data community provider key opinion leader perspectives support expanded use emergency contraception senegal sources information paper draws four data sources literature review secondary analysis household survey conducted urban reproductive health initiative iii depth interviews key opinion leaders quantitative survey healthcare providers range service delivery points analysis data knowledge among women low urban areas women heard method ever used serious gaps providers technical knowledge knew mode action aware need timely use within moreover nearly half reported reluctance provide married women even fewer willing provide youths particularly adolescent girls responses key opinion leaders mixed demonstrating ambivalence could offered conclusion senegal current positive political climate family planning provides good opportunity strengthening programming address knowledge attitudinal barriers among providers key opinion leaders communities
objectives study aimed evaluate influence fungal infection antifungal treatment outcome patients walled pancreatic necrosis methods retrospective description fungal infections cohort consecutive patients undergoing endoscopic transmural drainage necrosectomy treated tertiary referral center reviewed results fungal infection documented patients common isolates first positive culture candida albicans candida glabrata thirty nine patients treated antifungals first fungal finding significant difference mortality organ failure group treated adequate antifungals first fungal finding compared group treated treated inadequately hospital mortality patients concomitant fungemia found patients died opposed fungi necrosis conclusions study demonstrates high incidence associated high hospital mortality fungal infection thus emphasizing importance fungal infections
objectives study aimed explore role mir pathogenesis osteoarthritis methods human cartilage cells transfected mir antisense oligonucleotides aso mir treated beta subsequently expression collagen type alpha col alpha aggrecan acan concentrations sulfated glycosaminogly cans sgag matrix metallopeptidase mmp assessed luciferase reporter assay qrt pcr western blot performed explore whether pre cell leukemia homeobox pbx target mir furthermore cells transfected mir pbx expressing vector cells transfected mir treated nuclear factor kappa antagonist changes cola acan expression sgag mmp concentrations measured statistical comparisons made two groups using two tailed paired test results expression mir elevated cartilage tissues chondrocytes beta stimulated cells mir overexpression enhanced beta induced regulation cola acan sgag increased beta induced overexpression mmp pbx direct target mir pbx transfection attenuated effects mir expression cola acan sgag mmp conclusion overexpression mir might enhance beta induced cartilage degradation factors effects might via targeting pbx regulating kappa
objectives study investigated cost effectiveness early cardiac resynchronization therapy crt implantation among patients mild heart failure differential cost effectiveness crt using defibrillator crt crt using pacemaker crt also assessed background cardiac resynchronization shown cost effective new york heart association nyha functional classes iii less studied class incremental costs early crt implementation mild compared costs potentially avoided delaying disease progression advanced also unknown finally combined biventricular pacing defibrillator crt devices expensive biventricular pacemakers crt relative cost effectiveness controversial methods data year follow phase reverse resynchronization reverses remodeling systolic left ventricular dysfunction used economics evaluated medicare perspective based published clinical projections results probabilistic estimates yielded quality adjusted life year qaly gained confidence interval qaly gained crt versus crt programmed pre specified post implantation timings qaly gained crt versus crt qaly gained patient lifetime results robust choice patient subgroup alterations key model parameters early crt class strategy totaled compared late implantation early implant offered average year additional survival resulting icer gained conclusions study demonstrates crt cost effectiveness mild incremental crt costs justified anticipated benefits despite increased procurement costs shorter generator longevities early crt implants essential cost parity late implants increasing patient survival american college cardiology foundation published elsevier
objectives explore presence ptsd potential correlations risk developing ptsd lifetime mood spectrum signs symptoms assessed mood spectrum questionnaire lifetime version moods sample survivors liquid gas train crash italy methods one hundred eleven subjects assessed structured clinical interview axis disorder scid mood spectrum questionnaire moods lifetime version impact event scale revised ies trauma loss spectrum questionnaire tals results sixty six subjects completed scid met criteria ptsd ptsd patients showed higher comorbidity rates generalized anxiety disorder gad lifetime current major depressive disorder mdd subjects develop ptsd lifetime moods sociability extraversion factor prevalence lifetime mdd differentiated subjects without ptsd multiple logistic regression analysis performed conclusions although research needed results show significant correlation risk developing ptsd mood spectrum comorbidity
objectives identify predictors alcohol related patient physician discussions design cross sectional study using baseline data randomized controlled trial setting community based group practice participants thirty one physicians project senior health alcohol risk education patients aged older use alcohol completed survey included comorbidity alcohol risk evaluation tool caret measurements study baseline older adults asked whether alcohol related discussions physician occurred prior year outcome modeled using logistic regression models physician random effects predictor variables included patient level variables demographics seven caret defined risk factors specifically medical psychiatric comorbidity alcohol might worsen potentially alcohol related symptom use medication may interact negatively alcohol excessive quantity frequency alcohol use binge drinking concern others drinking drinking driving physician level predictors age sex years since graduation specialty also included results probability reporting alcohol related discussions declined patient age odds ratio patients aged significantly lower latinos drinking driving concern others significantly associated alcohol related discussions comorbidities using medications may interact alcohol conclusion although patient demographics including age ethnicity associated occurrence alcohol related discussions clinical factors may negatively interact alcohol increase risk suggests physicians may attuned entire spectrum alcohol related risks older adults
objectives cluster headache rare disease predominant men sex ratio four men one woman characterized frequent painful paroxystic attacks occurring sometimes eight times day disease without lesion impairs quality life patients attacks occur hemiface last minutes hours pain particularly severe frequent extreme psychiatric symptomatology observed attacks treatments rare always efficient sumatriptan oxygen lsd psilocybin paper try answer question make cluster headache attack using elicitation interview developed vermersch patients methods ten patients interviewed using elicitation interview min one interview patients seven men three women suffer chronic episodic mean age years patients come lariboisiere hospital paris precisely center headache urgency allows describing pre reflexive consciousness contents method described balzani petitmengin see bibliography data analyses performed using interpretative phenomenological analysis ipa results distinguished three phenomenological axes following heidegger philosophy alteration world strong unbearable feeling imprisonment physical restriction time patients present stereotypical automatic behavior motor schemes escaping strategies pain arises want leave far aggressive behaviors frequently occur sometimes patients able perform sumatripan injection due motor inhibition patients try autohypnosis methods resist pain alteration self going corporal distortion body dissolution onset symptoms patient experience physical deformation particularly face strong vegetative symptoms patient able control corporeal manifestations tears mad thinks incoherent projects order stop crisis patients want remove part body pain intense eye example losing body limits loss time orientation many cases pain unbearable patients want commit suicide extreme sensation self seems destroyed patients evoke experience similar near death experiences describe experience swaying emptiness imminent death alteration going imperative solitude acceptance presence without words solitude experience patients accept anybody another person unbearable asking questions crisis time patient scared solitude since able speak painful experience summary structure self altered thinking completely disturbed experience time space modified pragmatism consequence intense pain crisis pain central patient lives kind dissolution near death self dismantling conclusion allowed describe precisely painful experience subjects cluster headache experience rich intense phenomenological method useful method describe precisely symptomatology disease pays attention effective experience pathological flesh compared pathological body elsevier masson sas rights reserved
objectives semantic pragmatic disorder affects use language social context however therapists agree upon whether semantic pragmatic disorder belongs autism spectrum entirely separate condition rapin allen first defined semantic pragmatic disorder spd language disorder confusion surrounds use diagnostic terminology area spd neurology psychology psychiatry speech language therapy converge nowadays common definitions spd language impairment manifestation autistic spectrum disorder disorder language impairments autistic spectrum disorders multiple complex developmental disorders recently dsm identified new diagnosis called social communication disorder category characterized persistent difficulty verbal nonverbal communication explained low cognitive ability symptoms include difficulty acquisition use spoken written language well problems inappropriate responses conversation disorder limits effective communication social relationships academic achievement occupational performance paper discusses characteristics semantic pragmatic disorder well social communication disorder manage goal sensitize children psychiatrists children psychologists problem arrive precise diagnosis prescribe accurate treatments patient article present single clinical case based story young boy called mark case interesting age six mark diagnosed autistic spectrum disorder later age eight new examination pointed language impairment early teenager age mark reevaluated diagnosed multiple complex developmental disorder results today literature provide clinical studies allow differentiate semantic pragmatic language disorders disorders autistic spectrum multiple complex developmental disorders however interrogated speech therapist clinicians observed clinical individual differences throughout course treatment compared children suffering autistic spectrum syndrome children exhibit semantic pragmatic language disorder seem following characteristics initially fascination details less significant decreases time finally might disappear continuity ritual behaviors initially less significant decreases time finally might disappear better eye contact relationship others better variability facial expressions better capacity generalize learned new situation weaker requirement invariance even interests might restraint stereotypes diminish strongly time eventually disappear persevering difficulties use personal pronouns age seven late spontaneous acquisitions symbolic play pretend play clinical elements guide reflections concerning differential diagnosis deserve deeper understanding validity diagnosis conclusions symptomatology semantic pragmatic syndrome complex gives rise several different diagnostic hypotheses points importance necessity multidisciplinary evaluation complete detailed medical history child development persisting symptoms profile elements remain attentive important guide differential diagnosis treatment elsevier masson sas rights reserved
objectives link parent child central construction young subject link put distress adult suffers psychiatric disorders become toxic article proposes reflection impacts adult serious psychological troubles child discussion existing tension psychiatric care parent measures help protection towards child method try define elements answer authors lean experience multidisciplinary team compound social workers psychologists jurist doctors pediatrician child psychiatrist asked years realize diagnostic therapeutic care situations ill treatments children teenagers met different situations involving parents children within framework process multidisciplinary evaluation also base work network discussing colleagues charge therapeutic support adult patients results processes evaluation looks professionals close child meet parents adult suffering allowed seize relevance simplistic reading understand ins outs led ill treatment discussion spite concern respect every protagonist concerned holistic understanding course life confronted limits mission one hand bases therapeutic link hand example question shared professional secretly represents stumbling block affect process evaluation support purpose conclusion clinical experience theoretical reflections confirm interest complex multidisciplinary work integrating contributions visions professional asked estimate accompany one hand child hand parent elsevier masson sas rights reserved
objectives adherence allergic rhinitis clinical practice guideline considered potential focus national performance metrics help inform discussion assessed patient clinician reported medication administration among nationally representative populations patients allergic rhinitis study design cross sectional analyses setting subjects home health assessments ambulatory visits methods participants national health nutrition examination survey national ambulatory medical care survey national hospital ambulatory medical care survey assessed primary outcomes percentage patients reporting receipt antihistamines nasal steroids among allergy related symptoms percentage clinician administered medications diagnosing allergic rhinitis secondary outcomes included assessments worse quality life confirmatory allergy testing leukotriene receptor antagonist use results within national health nutrition examination survey estimated million patients diagnosed hay fever million diagnosed allergies patients symptoms allergic rhinitis reported antihistamines nasal steroids prescribed cases leukotriene receptor antagonists given without asthma use allergy medications within national ambulatory medical care survey national hospital ambulatory medical care survey observations representing million visits allergic rhinitis demonstrated nasal steroids administered cases nonsedating sedating antihistamines given respectively conclusions despite high prevalence allergic rhinitis per patient report clinician entry substantial number affected patients receive antihistamines nasal steroids
objectives aim determine non melanoma skin cancer nmsc risk patients psa exposed mtx dmards methods information medication collected patients psa two private rheumatology practices matched comprehensive histologically confirmed cancer registry data years relative risks rrs estimated logarithmic binomial modelling standardized incidence ratios sirs calculated year sex age specific rates nmsc local population results compared mtx usage mtx usage associated higher rate least one histopathologically confirmed nmsc sir sir receiving cumulative dose compared sir increased risk shown basal cell carcinomas squamous cell carcinomas apparent dose response relationship basal cell carcinomas squamous cell carcinomas increased risk nmsc patients taking csa pen addition mtx patients taking aza lef conclusion mtx concurrent mtx csa pen use associated increased risk nmsc results encourage greater clinical vigilance nmsc treated patients psa
objectives aimed investigate early changes expression type lectin domain family member cleca type lectin specifically expressed dendritic cell subset involved cross presentation cells evaluating gene protein expression three different compartments skin synovial tissue serum short term adalimumab treatment psa patients compared placebo methods patients active psa psoriasis randomized receive adalimumab placebo weeks synovial skin biopsies obtained weeks treatment serum samples weeks weeks year treatment skin serum healthy donors used control cleca expression assessed immunohistochemistry double immunofluorescence using terminal deoxynucleotidyl transferase deoxyuridine triphosphate nick end labelling tunel quantitative pcr elisa results cleca expression significantly higher psoriatic skin compared healthy donor psoriatic skin psa cleca cells close proximity tunel cells cleca levels significantly lower compared paired psa serum adalimumab treatment affect cleca serum level skin expression however cleca protein expression significantly decreased adalimumab treatment compared placebo group cleca gene expression remained unchanged positive correlation cell numbers cleca protein expression cell numbers chemokine motif receptor expression affected adalimumab treatment conclusion altogether present study suggests downregulation synovial cleca might associated novel mechanism anti tnf therapy might reduce mediated inflammation psa patients
objectives background parent knowledge child sleep may influence parent efforts support healthy sleep children present study aimed describe parent knowledge child sleep hospital cohort potential correlates including barriers children bedtime information seeking child sleep demographics child age parent education household income methods total parents children aged years attending hospital inpatient wards day ward approached individually invited complete questionnaire questionnaire items modified measures published articles identified literature review developed clinical experience results parents average answered half knowledge questions accurately knowledge child sleep positively correlated education household income parents sought information books internet greater knowledge child sleep parents endorse sources information accuracy parent estimations child sleep requirements varied within recommendations underestimated child sleep requirements overestimated parents correctly estimated child sleep requirements higher education income average likely parent younger children age years parents overestimated underestimated sleep requirements likely identify greater barriers child bedtime conclusion overall knowledge child sleep sample poor consistent samples north american communities future studies examine whether knowledge child sleep barriers children bedtimes related actual child sleep behaviors parent practices support children achieve healthy sleep elsevier rights reserved
objectives hypothesisblack race risk factor angioedema primary aim examine relationship race ethnicity risk factors angioedema study designusing retrospective case control study design data extracted clinical looking glass utility data collection management tool captures data electronic medical record systems within montefiore healthcare system cases emergency department visits primary secondary international classification diseases ninth revision code diagnoses angioedema adults aged years january december three montefiore centers bronx new york controls random sampling adult visits period methodsin primary analyses angiotensin converting enzyme inhibitor ace black race evaluated synergy influence different risk factors development angioedema evaluated using logistic regression models finally race ethnicity explored evaluating effect modification stratification models race ethnicity categories resultsthere cases controls randomly selected larger control pool ace use odds ratio confidence interval hypertension black race strongest risk factors ace use black race synergistic race ethnicity effect modifier certain risk factors conclusionrace ethnicity acts effect modifier particular angioedema risk factors two strongest risk factors ace use black race synergistic
objectives hypothesisthe purpose study report outcomes retrospective consecutive cohort study patients tnm glottic carcinoma treated radiotherapy study designretrospective case control study methodsthis retrospective review patients tnm glottic carcinoma treated radiotherapy january december department radiation oncology national cancer center singapore total patients included clinical endpoints interest local control overall survival disease specific survival dss prognostic factors also analyzed age gender smoking status substage dose fraction field size anterior commissure involvement total dose overall treatment time resultssix megavolt photon radiotherapy used patients photon radiotherapy patients median follow years year follows year dss patients significant difference radiotherapy respectively univariate analysis none prognostic factors statistically significant twenty patients developed second primary cancers majority lungs conclusionssix megavolt photon radiotherapy yields comparable results photons bolus computed tomographic simulation useful ensure adequate dose coverage target volume follow postradiotherapy incorporate chest imaging smoking cessation advice thyroid function test level evidence laryngoscope
objectives hypothesisthis study aimed investigate measure airway dynamics anatomical regions laryngeal cancer common comparison regions larynx thereby determining effect airway dynamics development laryngeal cancer study design methodspulmonary function test airflow data larynx anatomy measurement data obtained three dimensional computed tomography healthy male adult modeled simulation using ansys program analysis air flow rates pressure force also made resultsthe supraglottic region average pressure higher compared subglottic region clearly lower compared glottic region subglottic lowest pressure force levels glottic region first ranked location laryngeal cancer supraglottic region second frequency laryngeal cancer much lower subglottic region data suggests high pressure force contribute increased amount contact interaction toxic particles mucosa increased diffusion particles leading increased carcinogenic effect frequency cancer conclusionlaryngeal cancer found frequently regions increased pressure force stress reduced air velocity subsequent increase penetration inhaled toxic agents findings demonstrate importance basic physical fluid mechanics cancer pathogenesis level evidencena laryngoscope
objectives alteration peripheral iron indices reported number movement disorders particularly parkinson disease hypothesized iron stores may diminished children early stage tic disorder methods using data retrieved electronic medical records compared serum ferritin levels indicator body iron store balance drug naive children diagnosed first time tic disorder study group boys girls aged years compared age sex matched children headaches comparison group boys girls aged years treated pediatric neurological clinic results mean serum ferritin levels significantly lower tic disorder group compared headache group significant differences detected circulatory hemoglobin iron transferrin platelet count two groups conclusion findings suggest body iron stores may reduced children recent onset tic disorder
objectives although social anxiety associated higher prevalence smoking lower cessation rates little known underlying mechanisms relationships research suggests socially anxious smokers higher levels smoking specific experiential avoidance inclined smoke avoid internal smoking cues however unknown types internal smoking cues avoid thus study aimed address gap literature methods participants adult smokers group based trial smoking cessation bivariate correlations hierarchical linear regression models examined relationships baseline levels social anxiety acceptance internal smoking cues physical sensations emotions cognitions results social anxiety associated lower levels acceptance thoughts sensations emotions cue smoking controlling levels nicotine dependence depression generalized anxiety posttraumatic stress disorder social anxiety still explained unique variability overall acceptance internal smoking cues acceptance physical sensations emotions serve smoking cues social anxiety longer explained unique variability acceptance thoughts trigger smoking conclusions smokers high levels social anxiety less accepting internal smoking cues physical emotional cues effect independent level dependence mental health comorbidity results help explain smokers social anxiety less likely quit inform development targeted cessation treatments smokers social anxiety
objectives ambulatory systolic diastolic pressure regression index asdpri composite marker cardiovascular properties related complications however genetic determinants asdpri known aim study report relationship certain single nucleotide polymorphisms snp asdpri hypertensive patients cad confirmed coronary angiography methods total hypertensive subjects cad included snps selected genome wide association studies snps reported associated coronary artery disease risk significant differences daytime nighttime asdpris phctr lpa adamts polymorphisms genetic risk score grs constructed evaluate additive effect snps asdpri results analysis covariance revealed significant relationship ppabb wdr polymorphisms nighttime asdpri dipping analysis covariance revealed significant relationship grs asdpri conclusions conclusion adamts lpa polymorphisms related asdpri ppabb wdr gene polymorphisms associated nighttime asdpri dipping total asdpri determined grs
objectives life expectancy women cystic fibrosis improves reproductive decision making becoming increasingly relevant sought characterize fertility intentions contraceptive use preferences among adult females study design conducted cross sectional survey contraceptive use preferences reproductive aged women subjects recruited via electronic mailing list penn adult cystic fibrosis program results fifty three women responded met eligibility criteria sexually active however used contraception condoms oral contraceptive pill commonly used methods compared national contraceptive use among caucasian women use cohort significantly lower participants prioritized effectiveness ease use contraceptive method wanted avoid side effects interference sexual enjoyment although priorities similar caucasian women literature additional contraceptive priorities differed significantly groups conclusions cohort sexually active contraceptive utilization low women identify specific contraceptive preferences significant unmet need contraception among women elsevier ltd rights reserved
objectives temporomandibular disorder tmd knee osteoarthritis koa prevalent joint diseases however association reported therefore study investigated prevalence specific symptoms signs tmds ssts patients koa methods total patients koa healthy individuals recruited prevalence specific ssts patients mild severe koa compared prevalence specific ssts control group results analysed using chi square test logistic regression used adjust potential confounders gender age results prevalence impaired range jaw movement irm mild koa group severe koa group values koa groups significantly higher non control group addition patients severe koa reported impaired temporomandibular joint tmj function value significantly higher control group significant differences groups found ssts conclusions patients koa might likely experience ssts irm impaired tmj function
objectives china world largest population stroke become leading cause death recent years purpose study explore associations hypertension family history stroke diabetes mellitus obesity stroke among middle aged older farmers western china population based study conducted june april shaanxi sichuan provinces methods twenty thousand five hundred twenty five chinese middle aged older farmers years recruited qinling daba mountains region stroke study structured questionnaire used collect data face face interviews demographic characteristics risk factors medical history clinical characteristics recorded participants association hypertension family history stroke diabetes mellitus obesity stroke analyzed using univariate multivariate logistic regression analysis results stoke prevalence rate middle aged older farmers western china difference hypertension diabetes mellitus obesity family history different age groups statistical significance prevalence rate hypertension family history stroke higher male population female population difference statistically significant univariate logistic regression analysis demonstrated age gender hypertension obesity family history stroke stroke risk factors multivariate logistic regression analysis revealed odds ratios family history stroke obesity hypertension respectively conclusions family history strongest stroke risk factor middle aged older farmers western china
objectives deficits recognition negative emotions emerge clinical diagnosis huntington disease address emotion recognition deficits shown schizophrenia improved computerized training conducted study feasibility efficacy computerized training emotion recognition methods randomly assigned individuals premanifest early symptomatic training control group training group used self guided online training program microexpression training tool mett twice weekly weeks participants completed measures emotion recognition baseline post training time points participants training group also completed training adherence measures results participants training group completed seven eight sessions average results showed significant group time interaction indicating mett training associated improved accuracy emotion recognition conclusions although sample size small study demonstrates emotion recognition remediation using mett feasible terms training adherence evidence also suggests mett may effective premanifest early symptomatic opening potential new avenue intervention study larger sample size needed replicate findings characterize durability generalizability improvements impact functional outcomes
objectives epidemiological data shown individuals advanced fibrosis greatest risk premature morbidity non alcoholic fatty liver disease nafld individuals included clinical trials often highly selected remove confounding factors selection introduce bias limit external validity examined external validity trials nafld examining characteristics participants observational studies randomized controlled trials rct nafld design systematic review performed structured literature searches relevant rct using pubmed ovid embase identified studies screened inclusion authors data extracted study populations compared using tests compare means variances case weighted size individual studies dichotomous data compared chi squared test results total studies included rct including data individuals fifteen rct participants differed individuals regard age body mass index prevalence diabetes mellitus gender case pronounced differences seen rct participants patients advanced fibrosis comorbid conditions prevalent among individuals nafld frequent exclusion criteria rct conclusions characteristics participants randomized controlled trials differ wider population individuals nafld differences may reduce utility trial data individuals nafld greatest risk death
objectives estimating hiv incidence critical identifying groups risk hiv infection planning targeting interventions evaluating interventions time use reliable estimation methods hiv incidence thus high importance aim study compare methods estimating hiv incidence population based cross sectional survey design methods incidence estimation methods evaluated included assay derived methods testing history derived method probability based method applied data ndhiwa hiv impact population survey nhips incidence rates sex age cumulative incidence function age presented results hiv incidence ranged confidence interval per person years overall men per person years women women higher incidence rates men methods incidence rates highest among women aged years highest among men aged years conclusion comparison different methods showed variations incidence estimates agreement identify risk groups use comparison several distinct approaches estimating incidence important provide best supported estimate hiv incidence population
objectives studies addressed optimal follow hiv infected women cervical treatment study aimed compare performance three available tests detect posttreatment cervical disease hiv infected women kenya design prospective cohort study methods least months following cryotherapy hiv infected women evaluated concurrently visual inspection acetic acid via papanicolaou pap smear high risk human papillomavirus hpv testing women positive test low grade squamous intraepithelial lesion pap scheduled colposcopy biopsy among histological confirmation assumed truly negative cervical intraepithelial neoplasia cin testing negative three tests ability test alone combination detect cin calculated determine utility posttreatment follow results median age women years stage median cell count cells combination antiretroviral therapy median months posttreatment abnormal screen via pap hpv among women histological confirmation persistent recurrent cin single tests pap correctly classified cases highest specificity sensitivity whereas hpv highest sensitivity specificity via sensitive detection posttreatment cin specificity conclusion goal minimize number false negatives miss cin posttreatment population high risk due prior cervical disease hiv infection hpv based algorithms recommended copyright wolters kluwer health inc rights reserved
objectives patients femoral neck fractures total hip arthroplasty tha demonstrates superior outcomes compared hemiarthroplasty however hemiarthroplasty remains common treatment femoral neck fractures conversion rates unknown compared results procedures using medicare database methods assembled cohort patients years age icd diagnosis matching current procedure terminology code femoral neck fracture patients followed forward years minimum incidences dislocation mortality measured reoperation revision tha conversion hemiarthroplasty tha assessed current procedure terminology code groups compared proportional hazard models controlling age race sex comorbidity index results hemiarthroplasty represented patients treated using arthroplasty femoral neck fracture proportional hazard reoperation dislocation significantly lower hemiarthroplasty tha years fewer hemiarthroplasty patients underwent conversion total hip replacement patients treated tha likely alive years adjusted hazard ratio confidence interval conclusion patients treated hemiarthroplasty femoral neck fractures significantly lower proportional hazard reoperation treated tha tha may associated lower mortality
objectives first time ever emphasized inclusion healthy people goals sleep health emphasis national health aims national healthy sleep awareness project nhsap tasked propose questions inclusion next behavioral risk factor surveillance system brfss survey includes number questions target behaviors thought impact health means measure community sleep health total number questions could exceed five include assessment risk obstructive sleep apnea osa methods appointed workgroup met via teleconference face face venues develop inventory published survey questions used identify sleep health develop framework analyze strengths weaknesses current survey questions concerning sleep develop recommendations sleep health disease surveillance questions going forward results recommendation focus certain existing brfss questions pertaining sleep duration quality satisfaction daytime alertness add brfss existing questions make modified stop bang questionnaire minus neck circumference assess risk osa conclusions sleep health important dimension health previously received less attention national health surveys believe questions recommended upcoming brfss question banks assist important measures sleep health may help evaluate effectiveness interventions improve sleep health nation
objectives increased risk osteoporotic fractures multiple sclerosis patients compared general population reported purpose study assess risk osteoporotic low energy fractures cohort large hospital district southwest finland age adjusted total gender specific prevalence definite per population calculated point prevalence december materials methods patients comorbid fractures identified searching icd icd codes period hospital administrative data turku university hospital tyks southwest finland case ascertainment performed review medical records osteoporotic fracture defined low energy fracture pelvis hip femur tibia humerus collar bone ulna radius vertebrae rib control population fold age gender matched population results point prevalence december total confirmed cases experienced least one fracture study period relative risks rrs fractures osteoporotic fractures significantly increased patients compared controls particular rrs hip fractures fractures humerus elevated patients controls conclusions observed high prevalence southwest finland confirmed increased age adjusted comorbid risk osteoporotic fractures low energy fractures compared individually matched controls
objectives intraindividual variability iiv reaction time refers trial trial fluctuations responding across given cognitive task cross sectional research suggests iiv increases normal neuropathological ageing may serve marker neurobiological integrity raises possibility iiv may also predict future cognitive decline indeed neuropathology therefore conducted systematic review address issues methods search electronic databases embase medline psycinfo web science completed may identified longitudinal investigations iiv middle aged older adults results total studies initially identified met inclusion criteria nine included longitudinal iiv measures predicted subsequent outcome cognitive decline impairment dementia mortality baseline iiv results suggested iiv increased time particularly participants aged years greater baseline iiv consistently associated increased risk adverse outcomes including cognitive decline impairment mortality conclusions increased iiv time associated normal ageing however increases iiv found normal ageing may risk factor future cognitive impairment mortality measures iiv may therefore considerable potential supplement existing clinical assessment aid identification individuals risk adverse outcomes dementia death
objectives investigation potential differences perception expression emotional prosody stimulation non stimulation state parkinson disease patients treated subthalamic nucleus deep brain stimulation stn dbs materials methods group patients studied two distinct research tasks first one estimation prosody perception battery words sentences recorded professional announcer administered stn dbs state asked select correct prosody time procedure repeated stn dbs state second task estimation prosody expression patients given second battery recordings using words sentences different prosody asked reproduce prosody heard stn dbs states recorded voice later given healthy control listeners aware target prosody evaluated patients ability correctly reproduce prosody using point scale results overall performance participants perception prosody task dbs dbs state respectively specific percentages correct perception different types prosody ranged differ significantly dbs states rates misclassifications consistently favor dbs dbs state prosody expression dbs state rated normal listeners better compared dbs state conclusions regarding prosody perception significant differences found either overall performance patients prosody specific correct classification rates however particular stimulation states favor different misclassification directions dbs state negatively influences expression emotional prosody speech patients parkinson disease published elsevier ltd
objectives levodopa carbidopa intestinal gel infusion lcig indicated patients advanced levodopa responsive parkinson disease treatment motor fluctuations dyskinesias describe patients developed disabling diphasic dyskinesias lcig initiation methods clinical data patients consecutively treated lcig therapy obtained direct clinical observation detailed review medical records results within days lcig introduction identified subjects persistent disabling diphasic dyskinesia tried manage symptoms increasing morning lcig flow adding extended release formulations dopamine agonists levodopa carbidopa bedtime within month patients presented gradual reduction duration severity conclusions knowledge first report describing occurrence small cohort advanced patients lcig initiation wish draw attention clinicians risk developing disabling patients switched lcig monotherapy elsevier ltd rights reserved
objectives mucormycosis invasive fungal infection afflicting immunocompromised patients causing significant degree morbidity mortality purpose study provide comprehensive analysis describing epidemiology outcome mucormycosis scenario hiv infection methods systematically searched pubmed reports mucormycosis associated hiv eligible studies describe predisposing factor clinical form treatment survival outcome results included articles reviewed abstracts corresponding cases patients mostly men median count iqr cells intravenous drug use neutropenia corticosteroid use predominant associated factors main clinical forms disseminated renal rhino cerebral rhizopus lichtheimia spp main fungal isolates treatment consisted antifungal therapy surgery overall mortality rate varied site infection disseminated disease cerebral disease pulmonary infection cutaneous infection survival worse initiate antifungals antiretroviral naive admitted icu disseminated disease conclusions mucormycosis life threatening infection hiv patients clinician aware infection differential diagnosis hiv opportunistic infections british infection association published elsevier ltd rights reserved
objectives orbital surgery challenging procedure complex anatomy training could especially benefit dedicated study models currently available devices lack sufficient anatomical representation realistic soft tissue properties hence developed printed simulation device orbital surgery tactual haptic correct simulation relevant anatomical structures design setting participants based computed tomography scans collected patients treated third referral center hard soft tissue segmented virtually processed generate model orbit hard tissue physically realized printing soft tissue manufactured composite silicone model nucleus surrounding tissue negative mold model also generated printing final model evaluated group trainees oral maxillofacial surgery group consultants participants asked reconstruct isolated orbital floor defect titanium implant stereotactic navigation system available participants experience evaluated haptic realism correct representation surgical approach general handling model insertion implant orbit placement fixation implant usability navigated control items evaluated via nonparametric statistics poor good results group gave average mark versus group haptics rated surgical approach graded handling models rated insertion implants marked fixation implants also perceived realistic lastly surgical navigation rated conclusion project relevant hard soft tissue characteristics orbital anatomy could realized moreover possible demonstrate entire workflow orbital procedure may simulated hence using model training expenses may reduced patient security could enhanced association program directors surgery published elsevier inc rights reserved
objectives reduced dentate gyrus volume increased oxidative stress emerged potential pathophysiological mechanisms bipolar disorder however relationship dentate gyrus volume peripheral oxidative stress markers remains unknown examined dentate gyrus cornu ammonis volume longitudinally patients bipolar disorder healthy controls investigated whether associated elevated peripheral levels oxidative stress methods acquired high resolution structural magnetic resonance imaging mri images quantified hippocampal subfield volumes using automated segmentation algorithm individuals controls participants scanned twice study inclusion average years later addition measured peripheral levels two lipid peroxidation markers hydroxy nonenal hne lipid hydroperoxides lph results first demonstrated automated hippocampal subfield segmentation technique employed work reliably measured dentate gyrus volume second found decreased left dentate gyrus volume patients larger number depressive episodes predicted greater volume decline finally showed hne elevated hne negatively associated left right dentate gyrus volumes patients conclusions results consistent role dentate gyrus pathophysiology bipolar disorder suggest depressive episodes elevated oxidative stress might contribute hippocampal volume decreases addition findings provide support hypothesis peripheral lipid peroxidation markers may reflect brain alterations bipolar disorders
objectives research attempting identify similarities disentangle differences ethnic minority gender role beliefs largely absent literature gap remains qualitative examinations phenomena purpose study fill gap literature providing qualitative examination differences similarities gender role beliefs among african american vietnamese american women methods thematic analyses conducted data gathered focus groups african american women mean age years focus groups vietnamese american women mean age years women diverse generational religious educational backgrounds results two similar primary themes emerged women roles chief caretakers women responsibility fulfill multiple roles also similar experiences need convey strength self sacrificial two distinct differences emerged focus groups beliefs interpersonal interactions perceptions societal expectations conclusions study demonstrates conceptualization gender role beliefs although times similar diverges among culturally different groups account culturally nuanced differences measures gender role beliefs culturally tailored culturally specific however researchers largely excluded ethnic minority women development widely used measures gender role beliefs inclusion diverse women research help prevent pitfalls conflating ignoring intragroup differences among different groups marginalized women
objectives research demonstrates benefits complementary alternative medicine cam myriad environments yet majority cam services offered outpatient settings incorporating cam hospital settings may lead increased patient comfort well overall satisfaction hospital admissions studies examined cam services among inpatients therefore study assessed inpatients preferences beliefs regarding cam well stated willingness pay services design adult patients ranging age years years years recruited hospitalization university california san diego healthcare system inpatients completed brief individual interview gather perspectives common cam services including acupuncture aromatherapy art therapy guided imagery healthy food humor therapy massage therapy music therapy pet therapy reiki stress management inpatients asked cam therapies perceived potentially helpful willingness pay therapies perceived beliefs regarding use therapies results inpatients commonly perceived healthy food massage therapy humor therapy helpful willing pay healthy food massage therapy stress management inpatients commonly believed cam treatments would provide relaxation increase well increase overall satisfaction hospitalization conclusions study suggests cam services may beneficial addition hospitals demonstrated inpatients interest stated willingness pay services findings may help organizational leaders making choices regarding development cam services within hospitals particularly since significant percentage inpatients reported cam services would increase overall satisfaction hospitalization results merit attention given need increase cost savings enhancing overall patient experience today medical marketplace
objectives rugby union rugby popular sport high injury risk burden injury described incidence severity injury however reports ignored monetary cost injuries therefore aim study describe monetary cost associated youth rugby injuries design descriptive study quantified medical treatments injured players south african rugby union youth tournaments days work parents missed result injuries health insurer used data calculate associated costs methods legal guardians injured players contacted telephonically weekly basis returned play treatments costs estimated south african rands based insurance rates converted using purchasing power parities results players sought medical care tournament players average treatment costs high per player fractures expensive type injury players medical insurance higher costs without conclusions although minority players sought follow treatment tournaments cost injuries high players without medical insurance lower costs may indicate players receive adequate treatment injuries injury prevention efforts consider injuries high costs treatment players without medical insurance sports medicine australia published elsevier ltd rights reserved
objectives aim study ascertain influence knowledge interventions sexual reproductive health contraception practices among adolescent street girls kinshasa democratic republic congo methods cross sectional study carried among street girls years age standardised questionnaire used encompassing socio demographic data knowledge practices regarding sexual reproductive health network analysis carried results study comprised street girls mean age years range years mean time spent living streets years range years commercial sex reported confidence interval main source income last sexual intercourse used condom used hormonal contraception previous pregnancy reported current pregnancy previous pregnancies ended voluntary termination higher rate among youngest street girls years time spent living streets independently associated pregnancy odds ratio practices outcomes previous current pregnancy poorly correlated knowledge sexual reproductive health network analysis confirmed poor influence exposure intervention activities sexual reproductive health practices outcomes confirm centrality effect knowledge hiv aids conclusion street girls kinshasa extremely vulnerable regard sexual reproductive health especially youngest street girls behavioural biomedical interventions limited influence structural societal changes necessary positively impact street girls sexual reproductive health knowledge hiv aids risk pregnancy greater influence sexual reproductive health practices
objectives aim study evaluate association physicians understanding mechanism action emergency contraceptive pill ecp personal use practice informing patients method prescribing methods study carried sample obstetrician gynaecologists responded mailed questionnaire bivariate analysis used test association physicians personal use ecp understanding mechanism action practice informing patients method prescribing multiple poisson regression analysis carried identify variables independently associated two dependent variables results multiple regression analysis showed percentage physicians informed patients ecp significantly lower among needed used among living northeast brazil significantly higher percentage female male physicians provided information ecp percentage physicians prescribed ecp significantly lower among needed used among believed caused mini abortion proportion physicians ever prescribed ecp greater among worked exclusively private practice among worked state capital conclusions misconception emergency contraception could cause mini abortion associated denial potential users physicians personal experience needing use favoured likelihood informing potential users prescribing
objectives aim study investigate contribution smoking alcohol intake pancreas divisumon risk developing chronic pancreatitis methods consecutive patients underwent secretin enhanced magnetic resonance cholangiopancreatography compared consecutive patients without pancreatic disease underwent secretin enhanced magnetic resonance cholangiopancreatography irritable bowel syndrome results enrolled consecutive patients irritable bowel syndrome patients univariate analysis statistically significant differences sex mean age duration amount cigarette alcohol usewere found per receiver operating characteristic curve analysis thresholds cigarette alcohol consumption respectively cigarettes daily multivariate analysis independent risk factors male sex odds ratio smoking cigarettes per day drinking conclusions italian population confirmed smoking alcohol cofactors development study shows alcohol intake smoking habits important risk factors development
objectives goals study identify proportion early adolescents southern south america injured past year identify risk behaviours exposures associated injuries evaluate common types causes injury population methods used complex samples analysis examine cross sectional data students four countries south america participated global school based student health survey gshs results proportion students reporting least one injury past year required medical treatment caused least one full day missed school usual activities argentina uruguay chile bolivia significantly boys girls reported injuries injured students likely non injured students report anxiety induced insomnia physically attacked physical fight lonely past year also likely report bullied using tobacco drinking alcohol missing school past month boys girls common type injury reported broken bone dislocated joint common injury cause student falling however students able provide specific answer either question conclusion gshs conducted low middle income countries territories around world new waves data collection currently planned implemented utility injury data gshs would improved injury type cause response items updated better capture information self harm sports injuries statistics provide stronger foundation evidence based injury prevention interventions adolescent populations elsevier ltd rights reserved
objectives majority football injuries caused trauma lower extremities shinguards considered important measure preventing lower leg impact abrasions contusions fractures given benefits federation internationale football association introduced shinguard law made wearing shinguards matches mandatory study evaluated effect introduction shinguard law amateur players netherlands football season incidence lower leg injuries design time trend analyses injury data covering years continuous registration methods data retrieved system records emergency department treatments random representative sample dutch hospitals injuries sustained football patients aged years included except injuries achilles tendon weber fractures time trends analysed multiple regression analyses model fitted consisting multiple straight lines representing year period results patients predominantly males treated fractures abrasions contusions lower leg incidence lower leg football injuries decreased significantly following introduction shinguard law whereas incidence football injuries effect prominent weekends match days gender differences found conclusions results significantly show preventive effect shinguard law underlining relevance rule changes preventive measure wearing shinguards matches training sessions sports medicine australia published elsevier ltd rights reserved
objectives present investigation examined role sex family history alcohol drug use disorders temperament childhood behavior problems adult psychopathology adult alcohol use disorder aud severity methods structural equation modeling used examine multiple etiological pathways adult aud severity participants included treatment seeking male female individuals current lifetime dsm iii alcohol dependence abuse enrolled treatment outcome studies extensive assessment treatment entry used mixture retrospective current self report results results identified significant paths associated latent factor adult aud severity entry treatment path male sex family history drug use disorder predicted greater childhood behavior problems predicted antisocial personality disorder borderline personality disorder anxiety disorders anxiety disorders leading directly aud severity path family history aud predicted difficult temperament childhood predicted borderline personality disorder major depressive disorder anxiety disorders major depressive disorder ads turn predicted aud severity treatment entry conclusions present findings build literature heterogeneity developmental risk processes leading expression adult aud symptomology among patients presenting aud treatment
objectives purpose study assess state licensing administrative regulations promoting healthy sleep practices child care compare regulations national recommendations methods reviewed regulations related healthy sleep practices states territories child care centers centers family child care homes homes compared regulations institute medicine recommendations promote sleep child care including create environments ensure restful sleep encourage sleep promoting behaviors practices encourage practices promote child self regulation sleep seek consultation yearly sleep expert used cochran mantel haenszel trend tests assess associations geographic region number regulations consistent recommendations results mean number regulations states centers homes possible centers state regulations recommendations states regulations recommendations homes states regulations recommendations states northeast greatest mean number regulations centers homes states south fewest respectively geographic differences significant centers homes conclusions states northeast regulations consistent institute medicine sleep recommendations overall states regulations consistent recommendations
objectives relationship insulin resistance clinical subclinical hypothyroidism well documented hashimoto thyroiditis common cause hypothyroidism study aim reveal whether relationship exists insulin resistance euthyroid hashimoto thyroiditis material method study included patients positive thyroid autoantibodies pta euthyroid hashimoto thyroiditis healthy control groups insulin thyroid stimulant hormone tsh thyroid autoantibodies anti thyroid peroxidase anti tpo anti thyroglobulin anti homeostasis model assessment homa index fasting blood glucose low density lipoprotein cholesterol high density lipoprotein cholesterol triglycerides total cholesterol levels patients control group compared results age gender body mass index bmi thyroid stimulating hormone tsh free thyroxine free triiodothyronine differ patients control group fasting glucose levels insulin levels homeostasis model assessment insulin resistance homa values low density lipoprotein cholesterol levels high density lipoprotein cholesterol levels triglyceride levels total cholesterol levels significantly higher among patients positive thyroid autoantibodies control subjects found positive correlation among thyroid stimulating hormone anti thyroid peroxidase anti thyroglobulin homeostasis model assessment insulin resistance homa levels conclusion high thyroid autoantibodies levels related high fasting blood glucose levels insulin levels lipid parameters homeostasis model assessment insulin resistance homa values findings indicate possible relationship insulin resistance autoimmune thyroiditis thyroid stimulating hormone levels patients positive thyroid autoantibodies followed closely diabetes mellitus cardiovascular events
objectives risk pregnancy estimated times high among women use oral contraception times high among condom users among women use certain long acting contraceptive methods explored population level implications variation contraceptive efficacy study design used familyscape microsimulation model study effects nonmarital pregnancy rate movements along two different margins contraceptive behavior extensive margin captures decisions whether initiate use method contraception among noncontraceptors intensive margin captures choice methods among contraceptors model populated nationally representative sample women childbearing age results impact number nonmarital pregnancies would substantially different noncontraceptors adopted long acting methods began using oral contraception moreover nonmarital pregnancy rate would reduced twice much subset noncontraceptors began using condoms equal number pill users took long acting methods conclusions prevailing emphasis long acting contraception somewhat misplaced policymakers practitioners largest effects fertility outcomes change behavior sexually active women neglect use birth control seeking pregnancy implications women decisions methods use less impactful decisions whether use contraception policies affect method choice likely differ policies address underlying motivations noncontraceptors seeking pregnancy elsevier inc rights reserved
objectives lack epidemiological research adolescent gaelic games previous research primarily focusing elite adult males study aimed prospectively capture epidemiology injury male adolescent gaelic games one year design prospective cohort study methods two hundred ninety two years male adolescent gaelic footballers hurlers took part one year prospective epidemiological study injuries assessed weekly certified athletic rehabilitation therapist injury defined injury sustained training competition resulting restricted performance time lost play injury report form utilised standardise injury information results match injuries frequent gaelic footballers per hurlers per training injuries per respectively quarter injuries adolescent gaelic footballers hurlers overuse nature recurrent injuries also frequent particularly adolescent gaelic footballers lower limb injuries predominated football hurling particularly knee ankle hamstring injuries frequent footballers lower back injuries common hurlers minor injuries common hurling moderate severe injuries predominant gaelic football conclusions injuries frequent adolescent gaelic games study sets scene establishment injury prevention strategies risk population sports medicine australia published elsevier ltd rights reserved
objectives study addressed professors race ethnicity race related inequity information present influence students evaluations professors acknowledgment racial inequity motivation respond without prejudice mrwp collective guilt students evaluations professors mediate relationships method white american undergraduate students females first year mean age years age completed anonymous online survey students imagined taking racial diversity course either black white male professor presented either white privilege black disadvantage statements participants completed surveys assessed evaluations professor collective guilt beliefs regarding racial inequity mrwp results students evaluated white professors lower expertise learning conduciveness warmth intelligence rated black professors biased consistent inequality framing model intergroup sensitivity effect ise findings prejudice confrontation research white professors induced greater acknowledgment racial inequity discussed white privilege rather black disadvantage black professors induced external mrwp presented white privilege rather black disadvantage students perceptions professors warmth intelligence determined effectiveness inequity message perceptions professors expertise judgmental conduciveness learning determined students concerns appearing prejudiced conclusions presenters race ethnicity frame racial inequity information affect students evaluation presenters message effectiveness students external mrwp
objectives study aimed compare pharmacokinetics immunogenicity tolerability lbal biosimilar adalimumab originator humira healthy volunteers methods randomized double blind single dose two arm parallel group study conducted healthy subjects randomly received single subcutaneous injection lbal humira blood samples collected immunogenicity assessment parameters determined using noncompartmental method primary endpoint parameters compared using point estimates confidence intervals cis geometric mean ratios gmrs tolerability also evaluated results characteristics test reference drugs comparable gmr cis max auc inf lbal humira respectively within conventional bioequivalence criteria significant differences occurred frequency subjects anti adalimumab antibody positive responses drugs tolerability profiles including adverse events also comparable conclusion characteristics biosimilar lbal originator humira similar lbal humira show significant differences immunogenicity well tolerated single injection
objectives study examined current assessment practices clinicians working people social cognition impairment following traumatic brain injury method two hundred sixty clinicians completed line survey disseminated professional brain injury organisations respondents around allied health clinicians remainder comprising medical nursing academia main outcomes four areas social cognition routinely assessed across disciplines insight disinhibition anger social adjustment least routinely assessed areas theory mind alexithymia test suggested likely identify social cognition impairments awareness social inference test although clinicians responded question clinicians preferred informal assessment methods standardised assessment methods identifying social cognition rehabilitation goals higher levels education associated greater use standardised assessment modalities whilst paucity responses overall tbi express commonly used social cognition rehabilitation conclusions considering high prevalence social cognition impairments population formal assessment extremely limited utilisation assessment tools problematic assessment rehabilitation initiatives offered people tbi results implications training clinicians working brain injury rehabilitation
objectives study examined relationship salivary cortisol levels hot flashes midlife previous studies shown cortisol levels increase hot flashes laboratory higher cortisol levels associated severe hot flashes salivary cortisol levels also examined relation total number midlife symptoms methods women aged years reported presence absence symptoms including hot flashes previous weeks salivary samples collected waking min waking bedtime bedtime cortisol awakening response car cortisol daily decline cdd log transformed salivary cortisol levels time point mean cortisol levels compared hot flash report using tests logistic regression analyses performed assess association cortisol measure presence absence hot flashes controlling potential covariates results salivary cortisol levels significantly associated hot flashes sum symptoms hot flash report differentiate women positive car women showed strong cdd conclusion symptomatic women defined hot flash report symptom total found higher salivary cortisol levels elsevier ireland ltd rights reserved
objectives study investigates racial identity phenotypicality racial ambiguity shape perception biracial individuals white black perceivers investigated complex racial categorization downstream consequences perceptions discrimination method manipulated racial phenotypicality black racially ambiguous racial identity black biracial test cues influence black white race categorizations sample white black identified individuals results though racial identity phenotypicality information influenced deliberate racial categorization white black participants used cues different ways white perceivers racial identity phenotypicality additively influenced black categorization black perceivers however racial identity used black categorization racial ambiguity high perceived discrimination related white black perceivers distribution minority resources targets however black categorization related perceived discrimination black perceivers conclusion demonstrating black white individuals use identity phenotype information race perceptions provide complete view complexities racial categorization downstream consequences
objectives study assess frequency correlates women reports unintended pregnancy risk general population france study design data drawn fecond survey national probability survey sexual reproductive health conducted france identified women ages years heterosexual intercourse weeks prior survey potential risk unintended pregnancy evaluate women reports unintended pregnancy risk last weeks identify correlates reports using logistic regression modeling results fifteen percent women thought could become pregnant last weeks without wanting reports unintended pregnancy risk higher among women difficult financial situations foreign born women exposure form contraceptive practices errors use contraception strongest correlates women reports unintended pregnancy risk yet among women reported inconsistent use contraception unprotected intercourse last weeks think could become pregnant unintentionally conclusions significant discrepancies pregnancy exposure women report unintended pregnancy risk call better srh educational programs improve pregnancy awareness general population hand targeted interventions toward women report risk unintended pregnancy may contribute toward reducing unintended pregnancies given frequency events elsevier inc rights reserved
objectives ascertain differences across states children oral health care access oral health status factors contribute differences study design observational study using cross sectional surveys methods using national survey children health examined state variation parents report children oral health care access absence preventive dental visit oral health status assessed unadjusted prevalences outcomes adjusted child family neighbourhood level variables using logistic regression results presented directly graphically using multilevel analysis calculated degree child family community level variables explained state variation finally quantified influence state level variables state variation results unadjusted rates preventive dental care ranged mean little impact adjusting almost population fair poor oral health unadjusted range adjusting analyses affected fair poor oral health access child family community factors explained similar state variation preventive visit similar fair poor oral health state level factors contributed explaining third residual state variation conclusion geography matters child lives large impact access oral health care oral health status even adjusting child family community state variables state level variation persists factors richer data needed clarify variation drive changes egalitarian overall improved oral health royal society public health published elsevier ltd rights reserved
objectives assess veterans spinal cord injury sci amputated limb following patient demographics medical factors cultural psychosocial characteristic race wheelchair quality race independent associations patient race factors wheelchair quality design cross sectional cohort study setting three department veterans affairs medical centers affiliated academic medical centers participants eligible participants veterans sci als completed interview analyses restricted white african american participants variation wheelchair quality among patients excluded descriptive analyses leading final sample size interventions applicable main outcome measure wheelchair quality defined medicare healthcare common procedure coding system results found race differences many variables quality manual odds ratio confidence interval power wheelchairs several factors including age income associated wheelchair quality significant associations cultural psychosocial factors wheelchair quality conclusions although racial differences wheelchair quality found significant association older age lower income poorer wheelchair quality among veterans efforts needed raise awareness disparities among wheelchair providers take steps eliminate disparities prescription practice across sites published elsevier inc behalf american congress rehabilitation medicine
objectives assess effect insurance type medicaid medicare private insurance fragility fracture patients access endocrinology specialists postoperative period materials methods research team called board certified endocrinologists representative states caller requested appointment fictitious mother evaluated osteoporosis suffering hip fracture required surgery caller stated mother abnormal level parathyroid hormone mother orthopedic surgeon believed needed see endocrinologist office called times assess responses insurance type call documented whether patient able receive appointment barriers patient confronted receiving appointment results offices scheduled appointment patient medicaid compared medicare bluecross medicaid patients confronted barriers receiving appointments statistically significant difference access medicaid patients states expanded medicaid versus states expanded medicaid medicaid reimbursement new level patient visit significantly correlate appointment success rates wait times conclusion despite passage affordable care act medicaid patients reduced access endocrinologists complex barriers receiving appointments robust strategy increasing access care medicaid patients would equitable
objectives assess side effects unrelated disease activity acceptability combined oral contraceptives cocs progestin pills pops copper releasing intrauterine devices iuds women systemic lupus erythematosus sle study design randomized clinical trial including women sle assigned coc pop iud follow visits conducted months treatment monitor presence symptoms changes body weight blood pressure well development health problems relating lupus reasons discontinuation satisfaction use assigned method recorded end treatment statistical analysis included descriptive statistics repeated measure analyses kaplan meier curves results significantly different discontinuation rates due reason nonmedical reasons observed among coc pop iud groups nausea frequent among coc users dysmenorrhea among iud users acne hirsutism among pop users mean blood pressures remained unchanged mild increases body weight observed time treatment groups women satisfied use assigned contraceptive method conclusions oral contraceptives iud acceptable birth control methods patients lupus counseling specialized health attention provided however acceptability pop appears inferior side effects unrelated lupus disease activity frequent reasons discontinue contraceptive methods published elsevier inc
objectives determine rates luteal phase pregnancy lpp young women initiating subdermal implants day menstrual cycle study design assessed retrospective cohort young women receiving contraceptive implants adolescent title clinic patients negative pregnancy tests eligible day insertion regardless cycle day contraceptive use last intercourse computed lpp rates within manufacturer guidelines insertion days menstrual onset days post discontinuing hormonal contraception outside guidelines reviewed medical records last menstrual period lmp current hormonal contraception emergency contraception provision pregnancy tests weeks post implant placement later evidence pregnancy patients positive pregnancy tests reports used standard obstetrical dating lmp ultrasound determine conception occurred weeks implant placement results insertions outside recommended guidelines women insertions within guidelines older years likely white definitive pregnancy data documented patients within guidelines group outside guidelines group rates lpp within guidelines group outside guidelines group conclusion risk lpp following cycle day insertion contraceptive implants negative pregnancy testing low regardless menstrual cycle timing recent contraceptive use use elsevier inc rights reserved
objectives determine prevalence sporting injuries regional australian setting readiness rural health systems combat overall impact design setting participants five years data victorian emergency minimal dataset showing sports injuries presenting goulburn valley base hospital emergency department analysed main outcome measures prevalence overall sporting injuries including different types location injury body seasonal variation emergency presentation mechanism injury hospital admissions results observed total emergency presentations hospitalisations sporting injuries injuries presented winter sporting months rate injury higher month may across data reviewing years also higher proportion hospital admissions recorded winter sporting months reported played sports winter significantly younger summer sprains strains due different sporting activities commonest cause presentations falls collisions mostly reported mechanism sporting injuries conclusion might extrapolated data within regional setting need optimise emergency departments hospital bed availability emphasis orthopaedic involvements winter sporting months many sports injuries preventable community risk reduction strategies applied reduce burden regional hospitals
objectives evaluate association hypothyroidism health status older hispanic non hispanic white nhw men women accomplish determined prevalences treated untreated conditions examined associations elevated serum thyroid stimulating hormone tsh cognitive affective mood functions prevalences symptoms comorbidity specifically coronary heart disease chd diabetes hypertension hyperlipidemia design setting cross sectional study equal numbers hispanic nhw men women selected randomly health care financing administration medicare rolls recruited home interview followed hour interview examination senior health clinic participants volunteers mean age years participated interviews examinations measurements serum tsh determined participants responding questions thyroid replacement therapy serum free thyroxine free concentrations determined participants elevated tsh concentrations symptoms cognitive tests screen depression comorbidities chd risk factors lipid abnormalities diabetes hypertension compared participants high versus normal tsh values results subclinical hypothyroidism common women men non hispanic white women compared hispanic women differences observed participants tsh elevations normal tsh concentrations differences observed tsh concentrations conclusions subclinical hypothyroidism common condition community living older people especially women however appeared effect measures health status utilized serum tsh concentrations exceeded even effects rarely significant
objectives evaluate cost effectiveness first line treatment overactive bladder oab fesoterodine relative mirabegron spanish national health system nhs perspective methods decision tree model developed represent typical clinical process week treatment oab patient urge urinary incontinence uui initiating first line therapy fesoterodine including optional titration mirabegron efficacy data obtained bayesian indirect treatment meta analysis patients uui less one episode day defined treatment responder persistence assessed weeks week non responders discontinued treatment permanently quality adjusted life years qalys calculated based time spent responder non responder states oab related drug medical care costs including physician visits laboratory tests incontinence pads comorbidities fracture skin infection urinary tract infections depression modeled expressed sic results week percentage responders patients starting fesoterodine optionally titrated patients treated mirabegron qalys slightly higher fesoterodine mirabegron difference fesoterodine treatment also slightly higher total costs mirabegron sic difference sic resulting cost qaly sic gained fesoterodine versus mirabegron probabilistic sensitivity analysis confirmed slight advantage fesoterodine probability cost effective sic willingness pay qaly threshold conclusions given relatively small year cost difference two treatments fesoterodine considered cost effective option relative mirabegron first line management oab uui spain aeu published elsevier espana rights reserved
objectives examine association neighborhood safety support overweight obesity whether associations vary age sex race ethnicity among children adolescents design cross sectional setting united states main outcome measure childhood overweight obesity methods used data national survey children health representative sample children adolescents analyses using age sex adjusted growth chart parent self reported weight height data used classify participants overweight body mass index bmi percentile obese bmi used log binomial regression quantify association neighborhood safety support overweight obesity among children adolescents adjusting selected characteristics including physical activity amount time spent sedentary activities results children adolescents living non supportive neighborhoods higher probability obese peers living supportive neighborhoods controlling age sex race ethnicity parent education poverty asthma physical activity sedentary activities similarly probabilities obesity associated neighborhood safety support respectively however probabilities vary race ethnicity higher probability observed among non hispanic whites hispanics overweight non hispanic whites obesity conclusions living unsafe non supportive neighborhoods may associated overweight obesity among children adolescents longitudinal studies accounting race ethnicity needed examine importance social context children adolescents live
objectives explore perceptions palliative care needs patients idiopathic pulmonary fibrosis ipf caregivers background ipf carries poor prognosis patients succumbing illness rate comparable aggressive cancers prior studies comprehensively explored perceptions needs currently living disease caring someone living disease cared deceased family member methods thematic analysis focus group content obtained thirteen participants results four themes described frustration diagnostic process education received overwhelming symptom burden hesitance engage advance care planning comfort receiving care pulmonary specialty center resources conclusions findings support patients caregivers informational needs high symptom burden limited understanding potential benefits future studies needed identify optimal ways introduce early elsevier inc rights reserved
objectives explore relationship cognitive performance falls older people mild moderate cognitive impairment investigating mediational effects medical medication neuropsychological physiological factors design secondary analysis prospective cohort study setting community low level care participants older people aged years mild moderate mmse ace measurements global cognition six neuropsychological domains memory language visuospatial processing speed executive function affect assessed participants also underwent sensorimotor balance assessments falls recorded prospectively months results domain strongly associated multiple falls relative risk global cognition associated falls additional analyses showed participants poorer median cutpoint likely taking centrally acting medications less physically active also significantly worse vision reaction time knee extension strength balance postural sway controlled leaning balance higher physiological fall risk scores participants poorer times likely multiple falls mediational analyses demonstrated reaction time postural sway reduced relative risk multiple falls conclusions within sample older people mild moderate poorer increased risk multiple falls relationship mediated reaction time postural sway suggesting cognitively impaired older people poorer may benefit fall prevention programs targeting mediating factors
objectives identify perceived strengths international medical graduate img family medicine residents possess challenges perceived encounter integrating canadian family practice methods qualitative exploratory study employing focus groups interviews participants family physicians health care professionals family medicine residents focus group interview questions addressed strengths imgs possess challenges face becoming culturally competent within canadian medico cultural context qualitative data audiotaped transcribed analyzed thematically results participants identified img residents brought multiple strengths canadian practice including strong clinical knowledge experience high education level richness varied cultural perspectives positive personal strengths time img residents appeared experience challenges areas communication skills language nuances unfamiliar accents speech volume tone eye contact directness communication clinical practice uncommon diagnoses lack familiarity care opposite sex mental health conditions learning challenges limited knowledge canada health care system patient centered care ethical principles unfamiliarity self directed learning unease receiving feedback cultural differences gender roles gender equality personal space boundary issues personal struggles conclusions residency programs must recognize challenges occur cultural transition canadian family practice incorporate medico cultural education curriculum img residents also need aware cultural differences open different perspectives new learning
objectives investigate association reproductive history indicators hormonal exposure including reproductive period pregnancy use hormonal contraceptives mid late life cognition postmenopausal women design analysis baseline data two randomized clinical trials women isoflavone soy health early late intervention trial estradiol setting university academic research center participants naturally menopausal women measurements participants uniformly evaluated using cognitive battery structured reproductive history questionnaire outcomes composite scores verbal episodic memory executive function global cognition reproductive variables included ages pregnancies menarche menopause reproductive period number pregnancies use hormones contraception menopausal symptoms multivariable linear regression used evaluate associations cognitive scores dependent variable reproductive factors independent variables adjusting age race ethnicity income education results multivariable modeling age menarche older inversely associated global cognition last pregnancy age positively associated verbal memory use hormonal contraceptives positively associated global cognition trend verbal memory trend association hormonal contraceptive use verbal memory executive function strongest years use reproductive period positively associated global cognition executive function conclusion sample healthy postmenopausal women reproductive life events related sex hormones including earlier age menarche later age last pregnancy longer reproductive period use oral contraceptives positively related aspects cognition later life
objectives investigate effect stress involved nursing physical mental health nurses reduce efficiency design cross sectional descriptive survey method present study conducted investigate job stress among nurses three hospitals china data collected via socio demographic questionnaire nursing stress scale results found dimension nursing profession work issues strongest stress factor affecting nurses item shift work yielded highest stress score temporary contract nurses found higher stress level permanent contract nurses nurses working intensive care unit highest stress level units examined conclusion nurses high risk morbidity conditions long working periods sustained fast pace environment without stress management
objectives investigate urodynamic features women anterior vaginal wall prolapse compare prolapse degrees obtained urodynamic signs grup design prospective study setting ministry health bakirkoy sadi konuk training research hospital training research hospital subjects total neurologically intact women anterior vaginal wall prolapse evaluated cystosel stage graded according pelvic organ prolapse quantification pop divided three groups stage iii intervention full multichannel urodynamic test main outcome measure urodynamic parameters results incontinance established stage stage stage iii patients residuel urine volume much stage iii compared stage respectively urodynamic paramethers first sensation fill first desire strong desire void less stage stage iii respectively maximum bladder capacity much stage iii stage conclusions study showed anterior vaginal wall prolapse together incontinance even begining stage also sensation bladder reduces increase stages anterior vaginal wall prolapse mask incontinance signs women large anterior wall prolapse may weak detrusor contraction high postresidual urine volume
objectives review literature reporting factors associated delivery lifestyle support general dental practice methods systematic review quantitative observational studies describing activities promote general health adults primary care general dental practice behavior change included tobacco cessation alcohol reduction diet weight management physical activity tooth brushing oral hygiene behaviors excluded focus review common risk factors affect general health well oral health results six cross sectional studies met inclusion criteria five studies reported activities support tobacco cessation well tobacco cessation one study also reported activities related alcohol usage physical activity body mass index perceptions time availability consistently correlated activities beliefs tobacco cessation alongside smoking status dental professional dentists perceive available time likely discuss smoking patients prescribe smoking cessation treatments direct patients toward signpost lifestyle support services dental professionals smoke less likely give smoking cessation advice counselling nonsmokers finally data showed professional support may relevant professionals work solo practices felt lack support wider professional team peer support likely report barriers delivering lifestyle support conclusion organizational changes dental practices encourage team working professional time lifestyle support may influence delivery dental professionals smokers may require training develop beliefs effectiveness smoking cessation interventions
objectives urinary incontinence prevalent elderly populations dementia without dementia alzheimer disease common cause dementia urinary incontinence may complicate morbidity mortality therefore study aimed evaluate prevalence annual incidence determine risk possibility main type incontinence patients taiwan methods total patients included study cohort total patients without proportion compared study cohort used matched cohort participants selected national health insurance research database sample population utilize cox proportional hazard regression evaluate risk cumulative incidence ratio curve analyze cumulative incidence function prevalence annual incidence rate calculated individual medication including rivastigmine donepezil galantamine memantine initiated patients results risk higher cohort hazard ratio confidence interval cumulative incidence ratio event cohort matched cohort presents statistical significance annual incidence prevalence patients respectively conclusion present results suggest risk higher patients general population
objectives chronic pain places burden individuals economy although evidence effectiveness cognitive behavior therapy recognized effects limited acceptance commitment therapy act aims increase valued action presence pain suggested alternative approach objective review determine clinical effectiveness act chronic pain adults compared control conditions active treatments methods searches systematic review conducted cochrane library medline embase cinahl plus ebsco psycinfo grey literature reference list reverse citation searches also completed results eleven trials included act favored controls alternative intervention treatment usual significant medium large effect sizes found measures pain acceptance psychological flexibility typically considered processes act significant small medium effect sizes found measures functioning anxiety depression measures pain intensity quality life significantly different zero generally effect sizes smaller follow discussion act clinically effective controls number outcomes possible methodological limitations common psychological trials may led overestimated effects studies compared act active treatments evidence promising act treatment chronic pain methodologically robust trials required
objectives normal efficiency exercise induced hypoalgesia eih demonstrated people knee osteoarthritis recent evidence suggests eih may associated features pain sensitization abnormal conditioned pain modulation cpm aim study investigate whether people knee abnormal cpm dysfunctional eih compared normal cpm pain free controls methods forty peoples knee subdivided groups abnormal normal cpm determined decrease increase pressure pain thresholds ppts following cold pressor test abnormal cpm normal cpm control participants underwent ppt testing aerobic isometric exercise protocols group differences analyzed using repeated measures analysis variance within group differences analyzed using wilcoxon signed rank tests results significant differences demonstrated groups changes ppts postaerobic isometric exercise significant decreases ppts demonstrated postexercise abnormal cpm group significant increases ppts shown postexercise normal cpm control groups conclusions results suggestive dysfunctional eih response aerobic isometric exercise knee patients abnormal cpm normal function eih knee patients efficient cpm response identification people knee inefficient endogenous pain modulation may allow individualized graded approach exercises individuals
objectives article aims give spectrum estimation projection package epp users scientific community basic understanding underlying statistical model used incorporate hierarchical structure hiv subnational estimation show implemented spectrum epp interface improving subepidemic estimation article also provides recommended default settings new model methods apply generalized linear mixed effects model antenatal clinics prevalence data get area specific prevalence uncertainty estimates transform estimates auxiliary data fit epp model observed data auxiliary data results apply proposed methods four countries different levels data availability compare sample prediction accuracy proposed method varying auxiliary sample sizes epp without auxiliary data conclusion find borrowing information data rich areas data sparse areas using proposed method improves epp fit data sparse areas recommend using sample size estimated generalized linear mixed effects model default auxiliary sample size copyright wolters kluwer health inc rights reserved
objectivesborderline personality disorder bpd characterized emotional instability interpersonal dysfunction features typically develop background insecure attachment traumatic experiences dialectical behaviour therapy dbt proven highly effective reducing self harm improving emotion regulation whereby problems concerning social cognition also characteristic bpd may need additional approaches mentalization based treatment mbt methodshere examined pilot study effectiveness mbt given adjunct dbt compared dbt alone inpatient sample bpd whereby mentalization measured using novel cartoon based task resultsboth treatments highly effective reducing symptom severity combination dbt mbt superior reducing fearful attachment improving affective mentalizing conclusionsmentalization based treatment combination dbt may improve certain aspects social cognitive skills attachment security compared dbt alone although exact mechanisms led changes need studied practitioner points clinical implications dialectical behaviour therapy dbt usefully combined mentalization based treatment mbt combination dbt mbt reduces self harm dbt alone dbt plus mbt may lead reduction fearful attachment improvement affective mentalizing short term combinations evidence based borderline treatments may enrich psychiatric inpatient care therefore approaches deserve research limitations treatment condition therapeutically intense control condition study lacked follow assessment impact comorbid conditions treatment response taken account adherence manualized approach measured
objectiveshigh level emergency medical care requires transfer evidence based knowledge practice study first investigate feasibility checklists improving prehospital emergency care materials methodsthree checklists based standard operating procedures introduced general principles prehospital care acute coronary syndrome acute asthma acutely exacerbated chronic obstructive pulmonary disease subsequent prehospital care immediately transport information medical history diagnostic therapeutic procedures obtained data emergency missions recorded prospectively control group implementation checklists compared using test significance level resultsdocumentation patients history pre existing diseases medication allergies diagnostic measures oxygen saturation auscultation well basic treatment procedures application oxygen intravenous access increased significantly subanalysis acute coronary syndrome cases showed significant increase lead ecg use administration oxygen asa heparin blockers morphine chronic obstructive pulmonary disease subgroup oxygen supply application inhalative intravenous mimetics increased significantly conclusionintroduction checklists prehospital emergency care may help improve adherence treatment guidelines additional efforts team trainings made increase quality care
objectivesseveral studies shown perseverative worrisome thoughts prospectively related subjective health complaints shc short worry postponement intervention decrease complaints shc worry prevalent costly tested whether intervention offered online reduce complaints general population designa randomized parallel group trial conducted self selected participants general population methodsvia research website participants instructed register worrying consecutive days intervention group instructed postpone worry special min period early evening subjective health complaints inventory administered intervention daily worry frequency duration considered primary outcomes resultsthree hundred sixty one participants completed study contrary expectation registration group differ intervention group shc worry frequency duration nevertheless different worry parameters moderately related shc conclusionsin contrast previous studies using pen pencil versions worry postponement intervention study suggests direct online implementation effective reducing shc worry overall participants high trait worry levels reported difficulty postponing worrying reducing shc worries via internet might require elaborate interventions better incorporate advantages delivering interventions online already known subject perseverative cognition hypothesis argues perseverative cognition worry rumination acts mediator psychosocial stress may produce negative health effects prior research indeed shown worry subjective health complaints shc prospectively related causality studies showing changes worry induce changes health outcomes scarce mainly conducted young samples studies showed reducing worry using worry postponement intervention reduce daily worrying shc study add trait daily worrying associated shc online worry postponement intervention ineffective reducing worry shc paper pencil interventions directly used online interventions
objectivesthe aim study create validate severity levels central sensitization inventory csi valid reliable patient reported outcome instrument designed identify patients whose presenting symptoms may related central sensitivity syndrome css fibromyalgia chronic fatigue syndrome irritable bowel syndrome proposed common etiology central sensitization methodsbased csi score means standard deviations previously published subject samples following csi severity levels established subclinical mild moderate severe extreme concurrent validity csi severity levels confirmed separate chronic pain patient sample css diagnosis without demonstrating associations csi scores number physician diagnosed csss csi score distributions css non css patient samples patient reported history csss patient reported psychosocial measures known associated csss resultscompared non css patient subsample score distribution css patient subsample skewed toward higher severity ranges csi mean scores moved higher severity levels number individual css diagnoses increased patients scored extreme csi severity level likely report previous diagnoses fibromyalgia chronic fatigue syndrome temporomandibular joint disorder tension migraine headaches anxiety panic attacks csi severity levels also associated patient reported depressive symptoms perceived disability sleep disturbance pain intensity conclusionthis study provides support csi severity levels guideline healthcare providers researchers interpreting csi scores evaluating treatment responsiveness
objectivesto compare month outpatient healthcare expenditures risk risk drinkers aged older designsecondary analysis data project senior health alcohol risk education cluster randomized trial test efficacy intervention reduce risk drinking settingseven primary care clinics near santa barbara california participantscurrent drinkers aged older completed baseline survey receive study intervention including risk drinkers risk drinkers measurementscomparisons risk risk drinkers baseline demographic characteristics health indicators alcohol consumption adjusted unadjusted outpatient healthcare expenditures incurred months baseline resultsat risk drinkers younger often male likely married higher education incomes risk drinkers unadjusted month mean outpatient healthcare expenditures risk drinkers risk drinkers statistically significant differences expenditures groups controlling sociodemographic health characteristics conclusionin short term study adjusted differences healthcare expenditures observed risk risk older drinkers future study warranted determine role risk drinking long term healthcare expenditures older adults
objectivesto evaluate often beta blockers started acute myocardial infarction ami nursing home residents previously use drugs evaluate factors associated post ami use beta blockers designretrospective cohort using linked national minimum data set assessments online survey certification reporting records medicare claims settingu nhs participantsnational cohort residents aged older hospitalized ami may march taken beta blockers least months ami survived days longer readmission measurementsthe outcome beta blocker initiation within days readmission resultsfifty seven percent residents initiated beta blocker ami covariate adjustment use beta blockers less older residents ranging odds ratio confidence interval aged less residents higher levels functional impairment dependent totally dependent independent limited assistance medication use medications wide variety resident characteristics associated beta blocker use including sex cognitive function comorbidity burden ownership conclusionalmost half older residents united states initiate beta blocker ami absence observed factors strongly predict beta blocker use may indicate lack consensus manage older residents suggesting need develop disseminate thoughtful practice standards
objectivesto investigate effects tadalafil vascular endothelial function cardiovascular risk patients prostatic hyperplasia methodstadalafil given patients prostatic hyperplasia blocker ineffective voiding symptoms vascular endothelial function investigated weeks administration using commercial tests vascular function vascular endothelial function resultsthe participants median age years mean body mass index mean prostate volume measured using transabdominal sonography voiding symptoms significantly improved tadalafil based international prostate symptom score quality life index overactive bladder symptom score also significant improvements vascular function change brachial ankle pulse wave velocity weeks tadalafil weeks tadalafil vascular endothelial function change reactive hyperemia index change reactive hyperemia index significantly correlated international prostate symptom score quality life index brachial ankle pulse wave velocity conclusionsthe improvement intrapelvic blood flow tadalafil result improved vascular endothelial function addition improvement voiding symptoms change reactive hyperemia index seems correlate severity voiding symptoms tadalafil effective patients mild voiding symptoms
objectivesto understand range symptoms present family caregivers community dwelling persons alzheimer disease related dementias adrd designsix month longitudinal prospective study identify incidence new worsening symptoms association acute care medical service use settingcommunity based sample volunteers multiple states participantsa total patient caregiver dyads range dementia severity measurementsforty four symptoms signs common older persons persons dementia frequency emergency department visits hospitalizations death associations reported symptoms acute medical care resultsduring mean months follow new worsening organ specific participants nonspecific behavioral symptoms common average caregiver reporting seven new worsening symptoms common worsening confusion decreased activity agitation hallucinations delusions voice speaking problems eating drinking stress anxiety hospitalization emergency department use occurred respectively participants associated organ specific symptoms less nonspecific symptoms little behavioral symptoms within symptom category certain symptoms significantly associated acute medical service use conclusionfamily caregivers persons adrd must respond variety medical nonspecific behavioral symptoms high incidence new worsening symptoms acute medical care use suggests need better target symptom evaluation management caregiver education
objectivethe aims study investigate prevalence hepatitis virus hbv hepatitis virus hcv infection inflammatory bowel disease ibd patients risk factors related infection nonimmune status methodsa retrospective study carried two clinical centers prevalence viral markers risk factors related hbv hcv infection nonimmune status analyzed ibd patients age matched sex matched healthy individuals recruited controls resultsa total ibd patients included study present past hbv infection detected ibd group higher general population age older years ulcerative colitis previous surgery found significant risk factors hbv infection multivariate analysis patients ibd group nonimmune status hbv age less years crohn disease identified independent risk factors multivariate analysis prevalence hcv infection low similar general population conclusionthe prevalence hbv infection ibd patients china higher europe usa general population china prevalence hcv infection ibd patients similar general population study frequency nonimmune status hbv high especially young crohn disease patients hbv vaccination intensified targeted coverage copyright wolters kluwer health inc rights reserved
objectivethe current study tested whether interpersonal psychological theory suicide ipts provides useful framework understanding elevated suicide rates among individuals eating disorders eds methodbased predictions ipts tested whether combination thwarted belongingness perceived burdensomeness associated suicidal desire whether combination thwarted belongingness perceived burdensomeness fearlessness death associated past suicide attempts sample also compared ipts constructs sample versus general psychiatric inpatients college students non clinical comparison group resultswithin sample hypothesized interactions found perceived burdensomeness associated suicidal desire perceived burdensomeness fearlessness death associated past suicide attempts psychiatric samples greater thwarted belongingness perceived burdensomeness suicidal desire non clinical comparison group discussionthe ipts constructs perceived burdensomeness fearlessness death appear explain facets suicidality among people eds overall support ipts limited future research eds suicidality look beyond ipts consider biological sociocultural factors suicide wiley periodicals inc int eat disord
objectivethe differential diagnosis bipolar illness borderline personality controversial conditions manifest impulsive behavior unstable interpersonal relationships mood symptoms study examines whether mood clinical features differentiate conditions methoda total patients mean standard deviation age years female attending mood clinic examined diagnosis bipolar illness borderline personality disorder using scid scid clinical mood criteria extracted mood disorder questionnaire mdq analyzed using diagnoses dependent variables predictors bipolar borderline diagnoses identified multivariable logistic regressions predictive validity models assessed using roc curve analysis resultsbipolar illness strongly predicted elevated mood increased goal directed activities episodicity mood symptoms triad model predicted bipolar illness sensitivity specificity obtained auroc positive predictive value borderline personality disorder female gender statistically significant predictor predictive model obtained auroc conclusionin mood disorder clinic setting manic criteria episodic mood course distinguished bipolar illness borderline personality disorder
objectivethe profession psychology challenging demanding field particularly newly registered psychologists entering workforce resilience important factor psychologists success well therefore study aimed explore concept resilience among early career psychologists identifying factors strategies support resilience aspects work challenging early career psychologist study also explored universities could help graduates resilient methoda sample early career psychologists practising australia within various specialisations recruited participants asked five questions resilience contributing factors research team implemented qualitative method formulated interview schedule items determined literature interview data thematically analysed resultsdominant themes regarding workplace factors affect resilience concerned leadership organisational culture effort reward imbalance emotional labour strategies reported foster resilience early career psychologists included workload management professional development utilising peer networks reflection exercise socialising regarding university training pathway support australian psychological society colleges important well greater focus work placements supervision work integrated learning job relevant coursework self care education teamwork critical thinking skills work readiness initiatives career management support experience working within multidisciplinary teams conclusionsthis study shown important role universities workplaces play determining early career psychologist resilience findings new practical implications university curricula organisational practices
objectivethis study examined role expertise clinicians memory case details clinicians diagnostic formulations may afford mechanisms retaining retrieving information methodexperts males females report gender age mean members american board professional psychologists lay judges males females age undergraduates enrolled general psychology three vignettes presented group creating group expert lay judge vignettes simple complex coherent complex incoherent mixed factorial design recall accuracy vignette details dependent variable resultsdata analyses used multivariate analyses variance detect group differences among multiple continuous variables experts recalled information lay judges overall however experts also exhibited false memories complex incoherent case schema based knowledge conclusionsthis study supported clinical expertise beneficial nonetheless negative influences experts schema based knowledge exhibited could adversely affect clinical practices
objectiveto translate culturally adapt determine clinimetric properties danish item neck disability index ndi primary sector patients psps secondary sector patients ssps methodsanalyses included patients neck pain validity reliability assessed using cross validation factor analytical design hypothesis testing internal consistency measurement error smallest detectable change sdc generalizability study criterion construct responsiveness minimal important change mic floor ceiling effects determined resultsthe original danish version ndi unidimensional omitting items pain headache revealed factor structure ndi construct validity correctly predicted hypotheses internal consistency cronbach ranged generalizability high sdc psps ssps criterion responsiveness revealed poor areas curve ssps construct responsiveness poor psps correctly predicted hypothesis floor effect found psps change points representing mic conclusionthe modified danish item ndi unidimensional construct validity reproducible large acceptable measurement error however responsiveness poor significant floor effect found psps change score representing mic proposed psps
objectiveto assess patient hospital level factors associated home health care hhc referrals following nonelective patient hospitalizations data sourcethe national inpatient sample nis study designretrospective cross sectional multivariable logistic regression modeling assess patient hospital level variables patient discharges versus without hhc referrals data collectionanalysis included discharges patients years medicare principal findingsabout percent discharges referred hhc likely older age female sex urban location low income longer length stay higher severity illness scores diagnoses heart failure sepsis hospital location new england referent pacific conclusionsas health policy changes influence postacute hhc defining specific diagnoses regional patterns associated hhc first step optimize postacute hhc services
objectiveto assess association parental post traumatic stress disorder ptsd offspring ptsd specificity disorders non clinical epidemiological cohort australian vietnam veterans partners sons daughters methodveterans interviewed twice partners interviewed offspring total sons daughters interviewed families also included partners mothers children statistical analysis used multi level modelling compute odds ratios confidence intervals controlling clustering effects within families parent ptsd diagnoses examined associations offspring trauma exposure ptsd psychiatric diagnoses resultsveteran ptsd increased risk ptsd disorder sons daughters partner ptsd veteran depression also risk factor sons ptsd alcohol disorder linked alcohol dependence sons ptsd daughters controlling veteran ptsd conclusionwe conclude ptsd vietnam veteran father increases risk specifically ptsd sons daughters
objectiveto examine sex age distributions neuroleptic malignant syndrome nms patients based systematic literature review methodembase pubmed databases searched identify observation nms published january november accessible interpretable using language translation software redundant equivocal reports excluded sex ratio age distributions examined using standard graphical techniques measures association resultstwenty eight independent sex ratio estimates included males predominated estimates overall median sex ratio nms incidence peaked age years declined steadily thereafter males consistently outnumbering females oldest age intervals conclusionnms patients likely males nms likely occur young adulthood
objectiveto examine changes prevalence factors associated use emergency contraception britain spanning period deregulation increase pharmacy supply designcross sectional probability sample surveys setting populationbritish general population methodsdata analysed second third british national surveys sexual attitudes lifestyles natsal undertaken univariate logistic regression analyses used measure change use amongst sexually active women aged years intending pregnancy main outcome measuresprevalence use factors associated use resultsof women surveyed women surveyed respectively reported using year prior interview change time prevalence use increased amongst single women higher educational attainment adjusted odds ratio aor confidence interval increases use generally greater among women without behavioural risk factors history abortion within years aor whose first heterosexual intercourse occurred age years aor increase use also marked among women usually accessing contraception retail sources among healthcare sources may reflect use condoms amongst users conclusionthe increase use among women britain first decade century associated risk factors unplanned pregnancy advice provision may need targeted highest risk unplanned pregnancy tweetable abstractdespite pharmacy access small rise emergency contraception use seen britain years tweetable abstract despite pharmacy access small rise emergency contraception use seen britain years
objectiveto examine influence physician hospital market structures medical technology diffusion studying diffusion drug eluting stents dess became available april data sources study settingmedicare claims linked physician demographic data american medical association hospital characteristics american hospital association survey study designretrospective claims data analyses data collection extraction methodsall fee service medicare beneficiaries received percutaneous coronary intervention pci cardiac stent pci record joined characteristics patient procedure cardiologist hospital pci delivered accounted endogeneity physician hospital market structure using exogenous variation distances patient physician hospital locations estimated multivariate linear probability models related use des pci market structure controlling patient physician hospital characteristics principal findingsdess diffused faster markets cardiology practices faced competition conversely found evidence structure hospital market mattered conclusionscompetitive pressure maintain expand pci volume shares compelled cardiologists adopt dess quickly
objectiveto examine relative influence hospital skilled nursing facilities snfs day rehospitalization data sources settingselderly medicare beneficiaries newly admitted snf following hospitalization study designwe ranked hospitals snfs quartiles based previous years adjusted rehospitalization rates arrs examined rehospitalizations given hospital vary depending upon admitting snf arr quartile examined whether availability snfs low rehospitalization rates influenced hospitals snf readmission rates whether changes hospital arr years associated changes snfs discharge principal findingshospital readmission rates snfs varied percentage points patients discharged snfs lowest highest rehospitalization quartiles low rehospitalization rate hospitals sent larger fraction patients lowest rehospitalization snfs available area percent increase hospital share discharges lowest rehospitalization quartile snfs associated percentage point reduction hospital arr conclusionsthe snf rehospitalization rate greater influence patients risk rehospitalization discharging hospital identifying high performing snfs may powerful strategy hospitals reduce rehospitalizations
objective examine trampoline related injuries resulting emergency department attendance methods cases identified searching free text descriptions circumstances injury contained records emergency department large city hospital results cases identified month period giving incidence rate per population per year confidence interval compared hospital admissions per population per year confidence interval corresponding period reported earlier research new zealand suggested every one hospital admission approximately emergency department attendances cases aged less years earlier research falls trampoline surrounding surface commonest cause injury present study sprains strains commonest type injury body site frequently involved lower limb conclusions findings support conclusion earlier research although existing trampoline standards address many issues relating trampoline safety need remains measures reduce impact falls trampoline ground surface prohibit use trampolines unsupervised play equipment
objectiveto investigate demographic lifestyle factors associated adherence mediterranean diet israeli adolescents designcross sectional settingschool based subjectsschoolchildren aged years answered self administered questionnaires food consumption eating habits lifestyle subset also completed food recalls resultsusing modified kidmed index students poor average good adherence jewish middle school children highest proportion poor adherence olive oil usage derived food recalls jewish families arab homes jewish boys odds poor adherence higher watched television videos listened music sometimes read food labels jewish girls odds poor adherence significantly higher whose mother schooling years sometimes read food labels arab boys watching television videos listening music significantly associated poor adherence arab girls aerobic activity ball games weekly associated poor adherence conclusionsisraeli adolescents overall high rate poor adherence jewish middle school children highest risk interventions aimed increasing physical activity reducing sedentary time improving mother education promoting reading food labels recommended
objectiveto investigate differences widespread pressure pain hyperalgesia trigemino cervical extra trigeminal distant pain free regions women frequent episodic fetth chronic ctth tension type headache backgroundit seems people tension type headache exhibit central sensitization study investigated differences fetth ctth terms widespread pressure pain hypersensitivity methodsforty three women fetth ctth women without headache diagnosis recruited pressure pain thresholds ppts bilaterally assessed trigeminal area temporalis muscle extra trigeminal zygapophyseal joint two distant points second metacarpal tibialis anterior muscle blinded assessor clinical features headache collected week headache diary anxiety depression assessed using hospital anxiety depression scale hads resultsthe ancova revealed ppts significantly decreased bilaterally trigeminal mean differences ranging kpa extra trigeminal kpa distant points kpa fetth ctth groups compared controls anxiety depression influence pressure pain hyperalgesia associations widespread pressure hypersensitivity headache features observed conclusionscurrent results suggest presence similar local widespread pressure hyperalgesia associated anxiety depression women fetth ctth supporting localized central manifestations involved episodic chronic forms tension type headache
objectiveto investigate cost utility internet based intervention featback provided different levels therapist support comparison waiting list methodthis economic evaluation conducted societal perspective part randomized controlled trial participants self reported symptoms randomized weeks featback consisting psychoeducation fully automated monitoring feedback system featback low intensity weekly therapist support featback high intensity three times week therapist support waiting list participants assessed baseline postintervention month follow cost utility acceptability curves constructed resultsno significant differences study conditions found regarding quality adjusted life years societal costs although mean costs per participant lowest featback condition low intensity therapist support euro followed featback high intensity therapist support euro featback without therapist support euro waiting list euro featback seemed cost effective compared waiting list clear preference found featback without therapist support discussiona fully automated internet based intervention symptoms low high intensity therapist support represented good value money compared waiting list finding may important implications clinical practice unguided guided intervention could allow efficient care widespread dissemination potentially increasing accessibility availability mental health care services individuals symptoms wiley periodicals inc int eat disord
objectiveto measure variation payment rates medicare inpatient prospective payment system ipps identify main payment adjustments drive variation data sources study settingmedicare cost reports medicare certified hospitals dartmouth atlas geographic files study designwe measure medicare payment rate hospital total acute inpatient medicare part payment divided standard ipps payment geographic area assess variation using several measures within local markets nationally perform factor decomposition identify share variation attributable specific adjustments also describe characteristics hospitals receiving different payment rates evaluate changes magnitude main adjustments time data collection extraction methodsdata downloaded centers medicare medicaid services national bureau economic research dartmouth atlas principal findingsin medicare paid acute inpatient discharges rate percent ipps base top percent discharges mean rate double ipps base variations driven adjustments medical education care low income populations magnitude variation increased time conclusionsadjustments large growing share medicare hospital payments create significant variation payment rates
objectivevillous atrophy small bowel mainly related coeliac disease whose diagnosis made basis positive endomysial tissue transglutaminase antibodies gluten containing diet vast majority patients however also occur conditions whose epidemiology little known aim study epidemiology clinical features rare enteropathies patients methodsclinical laboratory data patients directly diagnosed centre last years collected statistically analysed resultsbetween september june patients diagnosed total patients also positive coeliac antibodies iga endomysial antibodies five common variable immunodeficiency three dermatitis herpetiformis two iga deficiency associated one abdominal lymphoma one unclassified sprue one olmesartan associated enteropathy one seronegative mortality deaths per person years confidence interval patients negative coeliac antibodies whereas deaths per person years confidence interval occurred coeliac patients conclusionpatients negative endomysial antibodies rare however forms identify specific causes diagnosed patients affected high mortality copyright wolters kluwer health inc rights reserved
obsessive compulsive disorder ocd polygenic neuropsychiatric disorder characterized repetitive thoughts behaviors cause distress pathogenic repeat expansion ggggcc found corf locus common cause amyotrophic lateral sclerosis als frontotemporal dementia ftd also documented patients psychosis schizophrenia furthermore obsessions compulsions identified patients diagnosed als ftd carrying pathogenic repeat expansion performed genetic screening corf repeat expansion patients diagnosed ocd none patients found carry expansion results show patients ocd commonly carry pathogenic repeat expansion therefore routinely screened ocd psychotic patients test positive corf however closely observed later development ftd als published elsevier
obvious vortex induced vibration viv observed section model wind tunnel tests single main cable suspension bridge optimized section configuration found mitigating excessive amplitude vibration much larger one prescribed chinese code order verify maximum amplitude viv optimized girder full bridge aeroelastic model wind tunnel test carried differences section full aeroelastic model testing results discussed maximum amplitude derived section model tests first interpreted prototype linear viv approach considering partial imperfect correlation vortex induced aerodynamic force along span based scanlan semi empirical linear model good consistency section model full bridge model found considering correlation vortex induced force along span
occlusion poses critical challenge computer vision long time recently technique synthetic aperture photography using camera array regarded promising way address problem occluded object imaging unfortunately expensive cost standard camera array system required calibration procedure still limits widespread popularity technique make synthetic aperture photography practical paper propose novel approach based mobile camera imu system moving planar surface contributions work include geometric property assumptions mathematically prove transformation matrices synthetic aperture image generation factorized infinite homography shift imu data utilized estimate homography selecting plane infinity reference plane scene independent require calibration compared conventional camera array based approaches proposed method effectively improves solution synthetic aperture images capturing generation using flexible convenient inexpensive system extensive experimental results qualitative quantitative evaluations demonstrated see occlusion performance satisfactory accuracy proposed approach different scenarios elsevier ltd rights reserved
oily wastewater caused serious water pollution development effective cheap oil water separation materials urgent treating problem herein inspired superhydrophobic typical plant leaves lotus red rose marigold superhydrophobic superoleophilic stainless steel meshes excellent oil water separation efficiency successfully fabricated facile immersion process surface modification stearic acid simple immersion process surface roughness low surface energy coating two dominant factors superhydrophobicity could accomplished sequentially found prepared surface superhydrophobic superoleophilic static water angle wca high degrees oil contact angle oca degrees furthermore prepared meshes applied separate oil water mixture bidirectionally exhibited excellent oil water separation efficiency including petroleum toluene hexane gasoline diesel even recycled ten times compared previously reported strategies strategy much easier carry meantime allows collection oil continuous manner study provides simple fast low cost environmentally friendly route fabricate oil water separation materials far large scale manufacturing considered prospective application industrial fields water treatment petroleum refining elsevier rights reserved
older adults greater prevalence urinary incontinence lower urinary tract symptoms urinary urgency nocturia waking sleep urinate bladder control problems place older adults increased risk falling associated wide range negative health rehabilitation outcomes rehabilitation clinicians identify assess bladder control problems patients provide basic interventions may improve quality life health rehabilitation outcomes aging adult clinical commentary aims systematically explain assessment treatment options bladder control problems elders used rehabilitation clinicians
older women pre fracture slow walk speed high body mass index high level multimorbidity significantly higher health care costs hip fracture compared without characteristics studies investigate targeted health care interventions individuals reduce hip fracture costs warranted aim study estimate associations individual pre fracture characteristics total health care costs hip fracture using study osteoporotic fractures sof cohort data linked medicare claims study population women age older enrolled medicare fee service ffs experienced incident hip fracture january december assessed pre fracture individual characteristics sof study visits estimated costs hospitalizations skilled nursing facility inpatient rehabilitation stays home health care visits outpatient utilization medicare ffs claims used generalized linear models estimate associations predictor variables total health care costs dollars hip fracture median total health care costs year hip fracture inter quartile range multivariable adjusted total health care costs year hip fracture higher walk speed compared higher body mass index compared higher seven compared comorbid medical conditions pre fracture poor mobility obesity multiple comorbidities associated higher total health care costs hip fracture older women studies investigate targeted health care interventions individuals reduce costs hip fractures warranted
oligella urethralis urethralis organism rarely causes infections humans report case year old bedridden woman progressive dementia placed long term care facility admitted hospital due fever unconsciousness pyuria abdominal computed tomography showed left pneumatosis urinary stone fluoroquinolones resistant urethralis identified matrix assisted laser desorption ionization time flight mass spectrometry maldi tof rrna gene sequencing isolated form blood urine cultures admission best knowledge first case emphysematous pyelonephritis caused urethralis elsevier gmbh rights reserved
basis introducing origin development finite time thermodynamics ftt paper reviews progress ftt optimization internal combustion engine ice cycles following four aspects studies optimum performances air standard endoreversible irreversibility heat resistance irreversible ice cycles including otto diesel atkinson brayton dual miller porous medium universal cycles constant specific heats variable specific heats variable specific ratio conventional quantum working fluids wfs studies optimum piston motion opm trajectories ice cycles including otto diesel cycles newtonian heat transfer laws studies performance limits ice cycles non uniform newtonian heat transfer laws well studies performance simulation ice cycles studies optimization objectives include work power power density efficiency entropy generation rate ecological function direction studies explored
hilbert space singular integral operator non carleman shift conjugation considered cauchy projectors continuous functions unit circle shift operator operator complex conjugation show symbolic computation capabilities computer algebra system mathematica used explore dimension kernel operator analytical algorithm adimker noncarleman presented several nontrivial examples given
oncogenic mutations braf lead constitutive erk activity supports melanoma cell growth survival signaling well known regulator tumor progression crosstalk signaling ras braf mek erk pathway much less explored show braf mutant melanoma cells abundance plasma membrane atpase isoform pmcab atpb low baseline markedly elevated treatment mutant braf specific inhibitor vemurafenib line findings gene expression microarray data also shows decreased pmcab expression cutaneous melanoma compared benign nevi mek inhibitor selumetinibsimilarly braf specific inhibitoralso increases pmcab levels braf nras mutant melanoma cells suggesting mapk pathway involved regulation pmcab expression increased abundance pmcab plasma membrane enhances clearance cells entry moreover show vemurafenib treatment pmcab overexpression induce marked inhibition migration braf mutant melanoma cells importantly reduced migration pmcab expressing braf mutant cells associated marked decrease metastatic potential vivo taken together data reveal important crosstalk signaling mapk pathway regulation pmcab expression suggest pmcab previously unrecognized metastasis suppressor new new results may give researcher another way attack metastatic melanoma commonly melanomas mutated copy braf current therapies focus mutants search new target molecules authors looked calcium ion signaling system promotes cell migration invasion found braf mutant melanoma cells less plasma membrane calcium ion pump molecule pmca treatment mutant braf inhibitor boosts pmca slows migration cancer cells furthermore pmca overexpression reduced metastatic potential cells vivo study first show pmca could hinder metastasis
one avenue substantially researched supported early childhood research importance cultivation self regulation skills classroom educational research self regulation skills illustrated importance enhancement skills long term academic success notwithstanding little empirical research early childhood links advancement self regulation skills contributing educational components cultivation children pro social skills review seeks establish link children self regulation pro social skills discusses implications future research practice
one critical task wind power interconnection study involves modelling wind turbines paper provides basic yet comprehensive time domain wind turbine model upon sophisticated models along power speed control mechanisms developed reason paper concentrates modelling fixed speed wind turbine model includes turbine aerodynamic mechanical electrical components data rotor drive train electrical generator given allow replication model entirety component blocks wind turbine modelled separately one easily expand model simulate variable speed wind turbines customise model suit needs aggregate wind turbine model wind farm developed followed four case studies demonstrate models used study wind turbine operation power grid integration issues results obtained case studies show models perform expected elsevier ltd rights reserved
one backbones indian economy agriculture conditioned poor soil fertility study use chemical soil measurements classify many relevant soil parameters village wise fertility indices organic carbon phosphorus pentoxide manganese iron soil type soil nutrients nitrous oxide potassium oxide order recommend suitable amounts fertilizers preferable crop classify soil parameters allows save time specialized technicians developing expensive chemical analysis ten classification problems solved using collection twenty diverse classifiers selected high performances families bagging boosting decision trees nearest neighbors neural networks random forests rule based support vector machines svm achieves best performance six ten problems overcoming maximum performance cases followed adaboost svm gaussian extreme learning machine although problems performance moderate classifiers fertility indices trained one region revealed valid indian regions elsevier rights reserved
one central subjects modern control engineering investigation stability arbitrary given nonlinear systems contribution introduce novel method compute domain attraction polynomial system using bezoutians presented method able estimate given system linear well nonlinear system works quadratic lyapunov function well arbitrary non linear lyapunov functions present algorithm succesfully determined inner outer bound inner bound yields enclosure lyapunov function countour line star
one challenges promoting computer science schools create retain interest programming describe pilot project primary secondary students macau introduce net gadgeteer rapid prototyping platform building electronic devices aim yearlong project generate interest building devices learning basics programming concepts experience weekend workshops indicates hands approach helped engage students results survey students point increased engagement active learning growing enthusiasm learn programming report issues surfaced give recommendations teachers wish consider devices teaching programming novices hope explore ways incorporate learning programming tangible devices curriculum local schools
one effect measures improving water flow fluidity solving city water pollution water diversion outside urban area different boundary condition quantity flow distribution velocity different every river velocity river channels even much smaller order enhance fluidity weak rivers small velocity set series sluice gates control gates closing opening need thus water quantity redistributed velocity increased need investigating effect setting closing gates unsteady river networks flow finite element model established verified bases model velocity size orientation every river water levels calculated condition whether setting gates numerical researches show water flow quantity velocity flow distribution increased significantly near river maximum velocity increment maximum banked water level maximum water lowering engineering effect obvious provided quantity data projects plan design
one hypotheses pathogenesis posttraumatic stress disorder ptsd dysfunction serotonin neurotransmission certain receptor subtypes likely critical symptoms ptsd studies examined role receptor development ptsd even though receptor critical contextual fear extinction anxiety like behavior therefore hypothesized stimulation receptor dorsal hippocampus could prevent hippocampal autophagy development ptsd like behavior animals end infused selective agonist single prolonged stress sps treatment rats three weeks later evaluated effects pharmacological treatment anxiety related behaviors extinction contextual fear memory also accessed hippocampal autophagy expression hta subunit beclin found sps treatment alter anxiety related behaviors prolonged extinction contextual fear memory behavioral phenomenon correlated increased hippocampal autophagy decreased hta expression increased expression beclin ratio furthermore intradh infusions dose dependently promoted extinction contextual fear memory prevented hippocampal autophagy decreased expression beclin ratio results indicated receptor hippocampus may play critical role pathogenesis hippocampal autophagy likely involved pathophysiology ptsd
one main challenges teaching statistics engineering students convey importance conscious presence variability taking account making technical managerial decisions often technical subjects explained ideal deterministic environment article shows possibilities simple electrical circuits wheatstone bridge among explain students characterize variability transmitted affects decisions additionally used introduce importance robustness showing taking account variability components allows design cheaper products greater benefits one simply apply formulas consider variables exact values results quite unexpected arouse interest motivation students supplementary materials article available online
one main issues preventing large scale exploration full potential memristors electrical circuits lies convergence issues numerical errors encountered computer aided integration differential algebraic equation set governing peculiar dynamical behavior nonlinear two terminal electrical components cases complexity equation set prevents analytical derivation closedform state solutions therefore investigation nonlinear dynamics memristors circuits based upon relies software based integration mathematical equations paper highlight solution accuracy issues may arise improper numerical integration equations propose techniques addressing problems properly guidelines represent useful guide engineers interested numerical analysis memristor models
one major challenges digital forensics today data encryption due leaked information unlawful sniffing many users decided protect data encryption case criminal activities forensic experts challenged decipher suspects data subject investigation common method overcome password based protection brute force password recovery using gpu accelerated hardware approach seems expensive paper presents alternative approach using task distribution based boinc platform cost time energy efficiency approach discussed compared gpu based solution
one challenging issues computer graphics generation images reflected transparent object image generated light reflection surface also light refraction object order generate image ray tracing powerful method ray tracing takes huge amount time trace ray emitted light source reaches eye pixel constructs image currently generate image fast using parallel processing based multi core gpu graphics processing unit ray tracing searches ray trace dividing ray two phenomena reflection refraction generates image recursive process image generated simple algorithm however image generated glass reflection refraction complex tell part image generated reflection refraction surface therefore propose analytical method draw image generated cubed glass reflection refraction method investigates ray trace parallel glass generates object mirrored reflection refraction addition generated image depends factors position reflective surface number total internal reflection proposed method draw image separately according number total internal reflection generates final image combining pre rendered image
one common personality disorders among adolescents young adults borderline personality disorder bpd objective current study assess three questionnaires reliably screen bpd adolescents young adults mclean screening instrument bpd msi bpd zanarini personality diagnostic questionnaire edition bpd scale pdq bpd hyler scid patient questionnaire bpd scale scid bpd nine criteria bpd according diagnostic statistical manual mental disorders dsm apa measured structural clinical interview dsm ivaxis disorders bpd scale scid first spitzer gibbon williams benjamin correlations questionnaires scid calculated addition sensitivity specificity questionnaires tested instruments predicted bpd diagnosis equally well
one effective means minimizing mortalities large raptors collisions hazards locate hazards away major activity centers reliable means delineating bird activity centers landscape significant impediment progress proactive infrastructure planning used brownian bridge movement modeling develop population wide utilization probability surface bald eagles haliaeetus leucocephalus within upper chesapeake bay used locations individuals tracked global positioning system gps satellite transmitters analysis intersected electrical network probability surface within aberdeen proving ground military installation identify overlap power lines eagle activity centers also overlaid locations eagle mortalities attributed lines installation assess relationship mortality rates utilization probabilities areas high bald eagle use relatively rare landscape area accounting estimated utilization electric lines along roads distributed away eagle activity centers lines located within areas highest estimated eagle use eagle mortalities highly skewed lines overlapped eagle activity centers eagle mortality rates birds times higher along lines associated highest eagle use compared lines associated lowest use suggesting estimated utilization may effective proxy mortality risk associated electric line hazards majority high use bald eagle areas delineated within study area existing electric lines utilization probabilities may potential tool site specific infrastructure planning wildlife society
one important controversial issues design implementation software functionality designed system impressive efforts different software teams field system primary concern developers proper error free functioning whole system therefore various tests defined designed help software teams produce error free software software minimum error rate difficult important find proper link written test class class test discovering links useful programmers perform regression test efficiently paper trying propose model recovery traceable links test classes classes test presented model comprises four sections firstly retrieve name similar classes test class source class afterward extract complexity cyclomatic design metrics source codes test classes finally creating train set implement data mining algorithms find potential relationship unit tests classes test one advantages method language independence furthermore preliminary results show proposed method good performance
one intriguing objectives teaching computer science mid adolescence high school students attracting mainly maintaining concentration within limits class number theories proposed numerous methodologies applied aiming assist implementation personalized learning environment approaches objectives paper empirical study performed support hour code initiative took place second consecutive year end previous year initiative presented number high school students motivation teaching computer programming evaluation students programming skills attempted aid questionnaire simple personalization framework presented order adapt students personal needs
one profound questions scientific study religion whether religion evolved ability stimulate cooperation sense group mutual help historical evidence bearing fundamental question scarce inconclusive relevant empirical experimental studies often shown association religious variables promotion collaborative attitudes sometimes causal link religion cooperation study evaluates quality evidence gathered date reviewing previously published theoretical empirical non experimental experimental experimental priming meta analytic hybrid studies identify difficulties current research methodologies including lack standard procedures conclude drawing conclusions existing literature permits regarding link religion prosociality arguing religion needs understood needing produce prosociality appear survive develop emerging surviving developing complex partnership moral attitudes behaviors
one prominent fine structures auroral hiss long hissler defined dispersed feature embedded within broadband auroral hiss emissions frequency range khz lasting longer theory limited evidence hisslers used remote sensing density characteristics altitudes thousands applying automatic threshold algorithm vlf data collected south pole daily june august auroral hiss identified days analyzed occurrence rate applicable mlt interval manual inspection intervals groups trains long hisslers identified days hiss occurred median lower upper frequency bounds features khz median frequency time slope khz median hissler repetition time within train hissler period hissler period frequency time slope inversely related data previous studies reviewed provide comprehensive description phenomenon contrary previous studies subsequent long hissler features found commonly overlap time evidence found inverse relationship hissler train duration geomagnetic activity
one oldest scientific topics equatorial aeronomy related spread includes efforts understand physical mechanisms responsible existence ionospheric region irregularities spread traces night time equatorial ionogram hence name manifestations observed first time abnormal ionogram huancayo years ago recently coming understand physical mechanisms responsible occurrence capricious day day variability several additional techniques used reveal spatial temporal characteristics region irregularities responsible phenomenon among chronological order radio star scintillations trans equatorial radio propagation satellite scintillations radar backscatter satellite rocket situ measurements airglow total electron content techniques using propagation satellite radio signals recently radar imaging techniques theoretical efforts old observations nevertheless years discovery jicamarca radar observations showed none theories put forward could explain completely observations showed irregularities detected altitudes stable according mechanisms proposed breakthrough came years later jicamarca showing stable regions become unstable non linear propagation irregularities unstable stable region ionosphere form bubbles low density plasma problem remained however primary instability mechanism proposed extended generalized rayleigh taylor instability slow explain rapid development seen observations gravity waves neutral background proposed seeding mechanism form irregularities instability would grow former difficult observe controlling parameter actual role still needs determined recently radar observations shown existence horizontal plasma drift velocities counter streaming neutral wind steep bottom region produces fast growing instability generalized rayleigh taylor instability grow mechanisms proposed would explain rapid development large medium scale irregularities observed including seen radars nevertheless proper quantitative theoretical mechanism would explain irregularities break important meter scale ones responsible radar echoes needs developed paper makes selective historical review observations proposed theories since phenomenon discovered current understanding
one promising approaches efficient management heterogeneous distributed computing environment use multi agent systems researchers want solve tasks environment need utilities description processing specific domain knowledge software hardware infrastructure multi component knowledge used effective decision making practice experience multi agent systems show knowledge representation non trivial problems proposed approach design conceptual model heterogeneous distributed computing environment based multi agent management important component model algorithmic knowledge provides support planning resources allocation dynamic decomposition problem subproblems knowledge represented semantic network describe semantic relations concepts unlike semantic web services semantic grids approach provides advanced planning abilities support parallelism scalability develop specialized high level tools designing using conceptual models authors published elsevier
one recent developments personality psychology emergence new construct grit emergence led proliferation studies advancing grit significant predictor various positive outcomes far little attention paid testing relevance various work related outcomes present paper unraveled grit validity predicting series work relevant outcomes namely organizational citizenship behavior role performance counter productive work behaviors job satisfaction five factor model ffm personality constructs assessed sample including worldng adults grit limited predictive validity ffm dimensions predicting focal outcomes consequently relevance workplace treated caution research conducted using grit basis personnel selection interventions focusing various aspects performance job satisfaction elsevier ltd rights reserved
one serious problem developed nations facing today death injuries due road accidents collision animal vehicle highway one big issue leads road accidents paper simple low cost approach automatic animal detection highways preventing animal vehicle collision using computer vision techniques proposed method finding distance animal real world units camera mounted vehicle also proposed proposed system trained images consisting positive negatives images tested various video clips animals highways varying vehicle speed per two second rule proposed method alert driver vehicle speed beyond speed though animal gets detected correctly driver get enough time prevent collision overall accuracy almost achieved regarding detection using proposed method
one strong risk factor coronary artery disease cad affects levels vitamin blood cigarette smoking supplementary effects coronary artery bypass grafting cabg smoking cessation patients therefore aim study examine level vitamin blood plasma one day one month cabg human blood collected patients men day month cabg patients smoker cabg declared smoking concentration vitamin blood plasma assayed fia method spectrophotometric detection mean value vitamin concentration day cabg mol mean month cabg mol mean average increase concentration vitamin times mean showed significant positive correlations pearson consider incorporating recommendations preoperative smoking cessation least one month prior cabg additional supplementation addition would relevant monitor level vitamin patients blood preoperative period elsevier masson sas rights reserved
one way study ecological implications induced hydropeaking represents coupling hydrodynamic models habitat suitability models hydrodynamic parameters typically used describe physical habitat indicator species article discusses differences habitat suitability assessment cfd modelling input habitat simulation tool casimir first part article accuracy hydraulic model evaluated comparing model results laboratory model laboratory channel erodible bed field measurements valsura river bolzano italy second part habitat suitability valsura river case study affected hydropeaking analyzed comparing different approaches reconstruction velocity field depth averaged velocities modelling bottom velocity field reconstruction log law approach modelling bottom velocity field modelling results show habitat suitability index hsi using hydrodynamic models significantly different differences ascribed higher capability depict features flow field highly variable heterogeneous boundary conditions possibility simulate near bed hydrodynamic parameters relevant certain target species particular hsi values using hydraulics lead larger areas highly suitable habitats compared simulations moreover considering entire flow range hydropeaking events habitat simulations bottom flow velocities modelling provide suitable habitats entire flow range representing availability stable suitable habitats habitat availability modelled flow velocity continuously decreasing increasing flow rates elsevier rights reserved
online video games afford play social interaction often anonymous among players around world predicted social identity model deindividuation effects undesirable behavior uncommon online gaming environments online harassment become pervasive issue gaming community study sought determine personality traits game related variables predicted two types online aggression video games general harassment skill based taunting insulting others intelligence sexual harassment sexist comments rape threats men play online video games participated anonymous online survey social dominance orientation hostile sexism predicted higher levels sexual harassment general harassment online games game involvement hours weekly gameplay additional predictors general harassment discuss implications online social aggression online sexual harassment online gaming also apply findings broader understanding online harassment cyberaggression cyberbullying forms online hostility computer mediated communication contexts aggr behav wiley periodicals inc
recently investigations relationship media violence exposure mve aggressive behavior focused brain functioning study examined relationship brain activation history media violence exposure adolescents using functional magnetic resonance imaging fmri samples adolescents psychiatric diagnosis disruptive behavior disorder dbd aggression compared investigate whether association mve history brain activation moderated aggressive behavior personality twenty two adolescents history aggressive behavior diagnosis either conduct disorder oppositional defiant disorder dbd sample controls completed emotional stroop task fmri primary imaging results indicated controls history low mve demonstrated greater activity right inferior frontal gyrus rostral anterior cingulate violent word condition contrast adolescents dbd high mve exhibited decreased activation right amygdala compared low mve findings consistent research demonstrating importance fronto limbic structures processing emotional stimuli research suggesting media violence may affect individuals different ways depending presence aggressive traits elsevier ireland ltd rights reserved
ontogenetic peculiarities catecholaminergic regulation three vitally important physiological processes described heart beating respiration early somatomotor activity subordinated autorhythmical regime submitted modulating effects noradrenergic dopaminergic mechanisms considered age related changes effect whose peculiarity polar changes reactions process maturation predominantly excitatory reactions early stages predominantly inhibitory ones
opencl portable interface used program cluster nodes heterogeneous compute devices opencl specification tightly binds workflow abstraction command queue specific device entire program best performance user find ideal queue device mapping command queue creation time effort requires thorough understanding match characteristics underlying device architectures kernels program paper propose add scheduling attributes opencl context command queue objects leveraged intelligent runtime scheduler automatically perform ideal queue device mapping proposed extensions enable average opencl programmer focus algorithm design rather scheduling automatically gain performance without sacrificing programmability example design implement opencl runtime task parallel workloads called multicl efficiently schedules command queues across devices within multicl implement several key optimizations reduce runtime overhead case studies include snu npb opencl benchmark suite real world seismology simulation show average users apply proposed scheduler extensions four source lines code existing opencl applications order automatically benefit runtime optimizations also show multicl always maps command queues optimal device set negligible runtime overhead
operating systems interface hardware user random numbers useful security simulation file systems form program access modern operating system blending items remotely accessed infrastructure forms basis supporting operating systems projects work describes hardware software communication infrastructure support student projects sharing remote hardware acquire background radiations events geiger counter transforming events random numbers providing numbers custom file system collectively hardware software provide inexpensive remote laboratory experience computing students
operational amplifier basis analog circuit technology whose reliability important circuit system order collect parameters online assess working life operational amplifier parameters online testing system designed system consisted typical operating circuit electrical connection test circuit device test dut besides parameters tested test circuit collected data acquisition system values parameters displayed accelerated degradation test adt designed heat source thermocouple pasted back heat sink temperature heat source controlled finally life operational amplifier operating normal stresses assessed mathematical methods results indicate proposed method valid online life assessment operational amplifier
operative treatment usually recommended displaced patella fractures several techniques advocated internal fixation patella fractures despite relatively good clinical outcomes demonstrated many studies postoperative morbidities fixation failure nonunion infection knee stiffness uncommon present new alternative treatment technique displaced patellar fractures april may used nitinol patella concentrator ntpc treat consecutive patients displaced patellar fractures injuries arose vehicular accidents cases direct falls onto knee cases sports injuries cases mean patient age years range years clinical assessments made using bostman knee score mos questionnaire medical outcomes study item short form health survey recorded final follow visit mean follow years range years final follow bostman knee scores excellent cases good unsatisfactory according mos evaluation average score range treatment patellar fracture ntpc may serve effective rigid fixation method multifragmented displaced inferior pole fractures also may provide continuous concentrative compression osseous healing process thus use ntpc may help restore functional integrity extensor mechanism permit early rehabilitation lower incidence postoperative complications
optical frequency domain reflectometry ofdr use polarization maintaining fiber pmf capable distinguishing strain temperature critical successful field applications structural health monitoring shm smart material location dependent measurement sensitivities along pmf compensated cross auto correlations measurements spectra form distributed parameter matrix simultaneous temperature strain measurement accuracy strain degrees achieved spatial resolution range
optimal sensor placement osp critical issue construction implementation sophisticated structural health monitoring shm system uncertainties identified structural parameters based measured data may dramatically reduce reliability condition evaluation results paper information entropy provides uncertainty metric identified structural parameters adopted performance measure sensor configuration osp problem formulated multi objective optimization problem extracting pareto optimal sensor configurations simultaneously minimize appropriately defined information entropy indices nondirective movement glowworm swarm optimization nmgso algorithm based basic glowworm swarm optimization gso algorithm proposed identifying effective pareto optimal sensor configurations one dimensional binary coding system introduced code glowworms instead real vector coding method hamming distance employed describe divergence different glowworms luciferin level glowworm defined function rank value crowding distance deduced non dominated sorting addition nondirective movement developed relocate glowworms numerical simulation long span suspension bridge performed demonstrate effectiveness nmgso algorithm results indicate nmgso algorithm capable capturing pareto optimal sensor configurations high accuracy efficiency
optimal supply trace elements prerequisite microbial growth activity anaerobic digestion bioprocesses however required concentrations ratios essential biotechnologies strongly depend prevailing operating conditions well feedstock composition furthermore bioreactors undergo complex physicochemical reactions may present free ions complex bound precipitates depending presence sulfur compounds organic macromolecules overcome deficiency various commercial mineral products typically applied processes addition heavy metals poses risk overdosing operating systems may toxic microbial consortia ultimately environment adequate supplementation therefore requires appropriate knowledge composition also speciation bioavailability however little yet fully understood specific issue evaluations typically include measurement total concentrations consider chemical forms exist thus detailed information bioavailability potential toxicity provided review provides overview state art approaches determine bioavailable anaerobic bioprocesses including sequential fractionation speciation techniques critical aspects considerations including respect sampling analytical procedures well mathematical modeling examined approaches discussed review based experiences previously published studies context cost action european network ecological roles trace metals anaerobic biotechnologies
optimization power system restoration path key issue system restoration following significant disruption northeast blackout united states canada restoration path optimization problem rpop calculate shortest restoration path specified nodes subject network security constraints rpop normally modeled large scale mixed integer nonlinear programming including routing components nonlinear steady state power flow equations intelligent algorithm widely used solve complicated problem due excellent optimization capability existing research concern generate method initial population paper orthogonal genetic algorithm adopted achieve optimal solutions orthogonal array method used generate initial population genetic algorithm method proven optimal select representative samples possible combinations due selected samples scatter uniformly feasible solution space finally ieee standard test systems used examine applicability proposed method simulation results demonstrate proposed method efficient traditional method
optimization processes essential element many practical applications engineering chemistry logistic finance etc fill knowledge gap practitioners optimization experts developed kimeme new flexible platform multi disciplinary optimization peculiar feature kimeme used problem algorithm design includes rich graphical environment comprehensive set post processing tools open source library state art single multi objective optimization algorithms memetic fashion algorithms decomposed operators users easily create new optimization methods combining built operators creating new ones similarly optimization process described according data flow logic seamlessly integrated external software computed aided design engineering cad cae packages matlab spreadsheets etc finally kimeme provides native distributed computing framework allows parallel computations clusters heterogeneous lans case studies industry show kimeme effortlessly applied industrial optimization problems producing robust results also comparison platforms market
optimizing environmental impacts buildings energy consumption emissions water material use must nowadays building certification standards serve opportunity regulate subjects paper investigates implementation new building quality standard estonia improve sustainability buildings looking quantifiable environmental impacts construction life cycle assessment lca methodology used evaluate building certification schemes used within new standard goal demonstrate standard quality sustainable real estate lifecycle stands name addresses life cycle impacts construction paper could serve illustrative example future users new building quality standard better understand aspects functioning differences certification schemes used within standard furthermore results suggestions help look requirements standard refine greater sustainability enhancement future buildings estonia paper based results master thesis hafencity university hamburg supervised wolfram trinius prof irene peters defended november authors published elsevier ltd
ordinary differential equations odes widespread many natural sciences including chemistry ecology systems biology disciplines control theory electrical engineering building celebrated molecules processes paradigm become increasingly popular computer science high level languages formal methods petri nets process algebra rule based systems interpreted odes consider problem comparing minimizing odes automatically influenced traditional approaches theory programming propose differential equivalence relations study basic intermediate language decidability results targeted class high level specifications ode implicitly represents uncountable state space hence reasoning techniques borrowed established domains probabilistic programs finite state markov chain semantics provide novel symbolic procedures check equivalence compute largest one via partition refinement algorithms use satisfiability modulo theories illustrate generality framework showing differential equivalences include well known notions minimization continuous time markov chains lumpability bisimulations chemical reaction networks recently proposed cardelli iii behavioral relations process algebra ode semantics prototype implementation able detect equivalences biochemical models literature reduced using competing automatic techniques
organic chemistry required course programs chemistry biology many health science careers historically considered highly challenging course significant failure rates many science disciplines teaching organic chemistry traditionally focused unstructured exposition centered delivery course material report details efforts transform teaching large section organic chemistry student centered approach use highly structured active learning format study authors examine student performance data homogeneous examinations course grades two groups students large public university comparison received highly structured active learning pedagogy received traditional unstructured lecture pedagogy organic chemistry data consist repeated cross sections different years total sample size regression propensity score matching psm used analyze student academic outcomes results suggest students exposed highly structured active learning pedagogy organic chemistry scored statistically significantly higher total points earned final exam scores higher probability increase final course grade results suggest increased structure conjunction active learning improved outcomes generally students received students lowest academic achievement levels experienced gains study significant causal analysis impact highly structured active learning academic outcomes
organic field effect transistors based poly bis octyldodecyl naphthalene bis dicarboximide diyl alt bithiophene ndiod fabricated characterized effect octadecyltrichlorosilane ots self assembled monolayer sam grafted sio gate dielectric investigated significant improvement charge mobility reached thanks ots treatment modifying technological parameters relating fabrication solvents also studied analyzed electrical properties thin film transistors using two dimensional drift diffusion simulator integrated system engineering technology computer aided design ise tcad studied fixed surface charges organic semiconductor oxide interface bulk traps effect dependence threshold voltage density energy level trap states also considered finally found good agreement output transfer characteristics experimental simulated data
organic rankine cycles orc using toluene hexamethyldisiloxane put forward means improving efficiency automotive heavy duty engines provide reference comparison study despite efficiency improvement potential current orc approach reaching required fuel savings within expected costs innovative pathways improve orc performance cost effectiveness great importance research community paper presents partial solution means conceptual overview simulation results orcs especially tailored high temperature applications fundamental revision heat transfer expansion characteristics presented without increasing system integration complexity characteristics attributed use formulated organic blends toluene significant blend component developed criteria blend screening methodology presented simulation results show equivalent expansion volume flow ratio product heat transfer coefficient area blends offer improvement net power resulted cost savings compared reference orc simulations conducted aspen hysys using peng robinson wilson fluid property packages elsevier ltd rights reserved
organic inorganic nano materials attracted growing attention due potential applications optoelectronic devices sensors heterogeneous catalysts reported preparation polynary nanocomposites composed poly vinylpyridine pvp functionalized multi walled carbon nanotubes mwntpvp silica nanoparticles nano sio viologens phosphomolybdic acid pma mwntpvp nano sio viologens covalently connected pma electrostatically adsorbed thermogravimetric analysis revealed nanocomposites composed mwnts nanosio well organic species others preparation processes compositions nanocomposites characterized using fourier transform infrared spectroscopy ray photoelectron spectroscopy field emission transmission electron microscopic images revealed nano sio benv particles strongly attached mwntpvp surfaces form mwntpvp nano sio benv triad nano cores cyclic voltammo grams mwntpvp nano sio benv casting films showed three couples redox waves potential range agcl designated electron transfer process viologen substituents mwntpvp nano sio benv mwntpvp nano sio benv center dot dimers three couples redox waves recorded casting films mwntpvp nanosio benv pma polynary nanocomposites potential range designated three successive electron transfer processes pma finally revealed present mwntpvp nano sio benv pma polynary composites could act efficient heterogeneous catalysts electrocatalytic reduction bromate elsevier rights reserved
organizational values guide acceptable behavior provide motivational dynamism marketing channel literature yet address impact values interfirm exchanges propose value congruence cooperating firms effective governance method research examines impact value congruence manufacturers primary distributors survey data manufacturing firms demonstrate perceived value congruence positive effect distributors performance moreover information sharing joint problem solving serve mechanisms partially mediate main effect research calls integration organizational values partner selection marketing channel governance elsevier inc rights reserved
osteoarthritis progressively degenerative joint disease influenced structural metabolic factors growing evidence subchondral bone involved symptomatic structural progression wnt pathway implicated progression expression function wnt inhibitors dikkopf dkk sclerostin sost unclear examined regional distribution dkk sost subchondral bone femoral head using resection specimens following arthroplasty patients presenting end stage cylindrical cores immunohistochemistry taken midpoint full thickness cartilage defect partial cartilage defect base osteophyte macroscopically normal cartilage subchondral bone thickest cores taken regions full cartilage defect thinnest cores taken osteophyte regions subchondral bone expression dkk sost observed exclusively osteocytes expression highest subchondral bone cores taken regions partial full thickness cartilage defects dkk sost expressed chondrocytes cores macroscopically normal cartilage current study describes regional cellular distribution sost dkk hip expression highest osteocytes bone underlying partial thickness cartilage defects however clear cause consequence alterations overlying cartilage however suggestive active remodeling process might targeted disease modifying agents
osteoarthritis one major health problems development progression obesity related believe higher levels insulin may explains link especially high levels insulin obesity metabolic syndrome induce numerous complications insulin increase proliferation chondrocyte simultaneously prevents differentiation moreover hyperinsulinemia reduces circulating level serum conversion mimicking hypothyroidism thyroid hormones necessary maturation chondrocytes maybe decreasing insulin levels prevents progression improve treatment process elsevier ltd rights reserved
osteoarthritis major cause chronic musculoskeletal pain impacts people aged first line analgesic treatments reported minimal short term effects use essential oils pain killer increased recently mentha spicata spearmint essential oil famous due anti flatulence effects one less known biological activity spearmint analgesic activity aim study confirm analgesic effects spicata essential oil review evaluated articles analgesic activities spicata essential oil different relevant databases pubmed science direct wiley taylor francis springer without limitation april different animal studies reported analgesic effects spicata essential oil main abundant compounds carvone limonene menthol also efficacy safety spearmint oil reducing pain severity confirmed osteoarthritis patients spite beneficial effects spearmint oil reducing pain large clinical trials required confirm efficacy safety spicata oil elsevier ltd rights reserved
osteoarthritis prevalent form joint disease afflicts population age costs economy nearly billion annually healthcare socioeconomic costs characterized joint pain dysfunction though pathophysiology remains largely unknown due avascular nature limited cellularity articular cartilage exhibits poor intrinsic healing response following injury significant research efforts aimed producing engineered cartilage cell based approach articular cartilage repair however knee joint mechanically demanding injury also milieu harsh inflammatory agents unforgiving mechano chemical environment requires tissue replacements capable bearing burdens use mesenchymal stem cells mscs cartilage tissue engineering emerged promising cell source due ease isolation capacity readily expand culture ability undergo lineage specific differentiation chondrocytes however date studies utilizing mscs successfully recapitulated structural functional properties native cartilage exposing difficult process uniformly differentiating stem cells desired cell fates maintaining phenotype vitro culture vivo implantation address shortcomings present concise review modulating stem cell behavior tissue development function using well developed techniques chondrocyte based cartilage tissue engineering
osteoporosis one common skeletal disease featured osteopenia adipose accumulation bone tissue nlrp inflammasome activation essential player aging related chronic diseases like osteoporosis particularly due causal caspase activation correlation adipose accumulation bone tissue moreover expression anti aging senescence sirt reported decline along aging major cellular contributor bone formation mesenchymal stem cells mscs multipotent stem cells processing mutually exclusive differentiatability toward osteocytes adipocytes therefore hypothesized nlrp inflammasome activation promotes adipogenesis repress osteogenesis mscs via inhibiting sirt expression activated nlrp inflammasome human mscs via lipopolysaccharide palmitic acid lps treatment self renewal maintenance adipogenic differentiation osteogenic differentiation lps treatment significantly increased nlrp expression decreased sirt expression promoted caspase activity mscs lps treatment also boosted adipogenesis mscs suppressed osteogenesis moreover inhibition caspase activity repressed adipogenic differentiation partially improved osteogenic differentiation mscs lps treatment study demonstrated pivotal roles nlrp inflammasome downstream mediator caspase progress osteo differentiation mscs offered novel therapeutic target treatment osteoporosis elsevier inc rights reserved
osteoporotic fracture increases risk premature mortality muscle weakness associated increased fracture risk low bone mineral density bmd however role muscle strength post fracture mortality well understood study examines change muscle strength measured quadriceps fracture defines relationship muscle strength post fracture mortality study involved women men participating dubbo osteoporosis study least one low trauma fracture ascertained ray reports age years median follow time years range determine change muscle strength fracture selected subset women men least two muscle strength measurements fracture event subset women men least two measurements fracture follow period women men died annual rate decrease height adjusted muscle strength fracture women men strength loss fracture significantly different fracture women adjusting baseline age bmd lower height adjusted pre post fracture quadriceps strength associated hazard ratio confidence interval increase post fracture mortality risk respectively similarly men lower height adjusted pre post fracture associated increased mortality fracture fracture muscle weakness accounted premature deaths fracture women men results indicate older individuals lower muscle strength independent risk factor post fracture mortality american society bone mineral research
osteoprotegerin opg implicated pathogenesis postmenopausal osteoporosis metabolic bone diseases caused estrogen deficiency previous studies demonstrated estrogen may stimulate opg expression osteoblast cells transcriptional level however whether estrogen regulate opg expression post transcriptional level remains elusive present study aimed investigate role microrna mirna estrogen mediated opg production human osteoblast like cells results elisa western blotting reverse transcription quantitative polymerase chain reaction qpcr confirmed estrogen may upregulate opg expression mechanistic studies indicated estrogen increased activity luciferase reporter harboring opg untranslated region utr bioinformatics analysis demonstrated potential targeting site opg utr mirna mir associated osteoblast differentiation results qpcr suggested estrogen suppressed mir expression addition dual luciferase assay qpcr western blot analysis indicated mir directly targets negatively regulates opg expression furthermore transfection cells mir mimics able partially inhibit induction opg expression estrogen thus confirming role mir estrogen mediated opg induction taken together results present study demonstrated estrogen may post transcriptionally regulate opg expression suppression mir expression
osthole active coumarin extracted dried fruits cnidium monnieri cusson known possess variety pharmacological activities present study investigated illuminated mechanisms underlying protective effects osthole experimental model allergic asthma results show osthole treatment significantly reduced ova induced increase serum ige inflammatory cytokines bronchoalveolar lavage fluid balf decreased recruitment inflammatory cells balf lung also effectively attenuated goblet cell hyperplasia mucus overproduction lung tissue addition western blot analysis demonstrated osthole blocked kappa activation may associated reduction inflammatory cytokine production data suggest osthole attenuated ova induced allergic asthma inflammation inhibiting kappa activation present study identified molecular mechanisms action osthole support potential pharmaceutical application osthole treatment asthma airway inflammation disorders published elsevier
focus realistically modeling forecasting dynamic networks face face contacts among individuals important aspects data lead problems current methods include tendency contacts move periods slow rapid changes dynamic heterogeneity actors connectivity behaviors motivated application develop novel method locally adaptive dynamic lady network inference proposed model relies dynamic latent space representation actor position evolves time via stochastic differential equations using state space representation stochastic processes polya gamma data augmentation develop efficient mcmc algorithm posterior inference along tractable procedures online updating forecasting future networks evaluate performance simulation studies consider application face face contacts among individuals primary school
goal article reflect role lego robotics played college engineering education last years starting introduction rcx ending introduction combining modular computer programming language modular building platform lego education allowed students ages become active leaders education build everything animals robotic zoo robots play children games importantly allows students develop different solutions problem provide learning community look first recent developments learning sciences help promoting student learning robotics share four case studies successful college level implementations build developments
goal improve initially fabricated ray optics figures applying magnetic field drive magnetic smart material msm coating non reflecting side mirror consequent deformation surface three dimensional report results working glass sample coated msms coated glass deformed dimensions surface profile measured zygo newview white light interferometer wli driving magnetic field produced via pseudo magnetic write head made two permanent magnet posts magnet posts moved bottom glass sample computer controlled translation stage system allowed four degrees freedom motion side side back forth rotation posts diameter vertical axis allow change orientation magnetic field horizontal plane sample established finite element analysis fea model predict deformations compare observed results order guide application magnetically controlled msms improve future ray optics figures
objective assess feasibility fdg pet noninvasive monitoring treatment response allogeneic stem cell transplantation sct myelofibrosis methods twelve patients myelofibrosis underwent fdg pet sct bone marrow uptake spleen uptake spleen size assessed sct compared hematologic response criteria bone marrow biopsies results patients achieve complete remission remained pet positive extent disease bone marrow metabolism spleen metabolism spleen volume decreased significantly patients complete remission pet sct sensitivity confidence interval specificity negative predictive value positive predictive value diagnosis residual disease conclusion fdg pet feasible noninvasive monitoring treatment response allogeneic sct myelofibrosis
previous research revealed rifampicin could protect pheochromocytoma cells rotenone induced cytotoxicity reversing aggregation alpha synuclein furthermore increasing evidence indicated misfolded alpha synuclein sumoylation important protein post translational modification easier solubilize less toxic investigated whether rifampicin could stabilize alpha synuclein prevent rotenone induced cells undergoing apoptosis enhancing sumoylation alpha synuclein expression sumo sumo two main proteins responsible sumoylation modification cells detected western blotting immunoprecipitation performed compare qualitatively sumoylation modification alpha synuclein cell viability apoptosis rate measured cck assay kit flow cytometry respectively targeted ubc key enzyme sumoylation modification pathway knocked ubc gene using short interfering rna treatment mol rifampicin increased expressions sumo sumo cells times compared control group meanwhile cell viability rotenone induced cells increased addition increased sumoylation activity cells stimulated rifampicin observed earlier compared cells treated rotenone alone sumoylation alpha synuclein significant rifampicin treated cells ubc upregulated cells however phenomenon protective effect rifampicin reversed ubc knockout conclusion rifampicin might reduce cytotoxicity rotenone induced cells promoting sumoylation synuclein elsevier inc rights reserved
research works context verifying integrity access control policies relational database management systems paper addresses following question terms security particularly access control information system actually planned thus important aspect help security architects verifying correspondence security planning real implementation present synthesis problem access control policy integrity within relational databases introduce proposal addressing issue especially focus verification validation conformity concrete role based access control policies formal environment finally illustrate relevance contribution case study
smart city contribution transportation oriented proposes dynamic road lane management system order share appropriately space devoted traffic historical view series solutions physical ict supported present proposal extensively supported date ict following main presentation describe system architecture working conditions present proposed simulator designed study operating driver conditions respect new traffic signs proposed also describe mock technology validation give preliminary information field deployment elsevier ltd rights reserved
success well individuals societies depend ability make wise social decisions important interpersonal matters leaders select individuals choose trust nevertheless impressions people shaped facial appearances consequently social decisions article summarizes research linking facial morphological traits important social outcomes discusses various factors moderate relationship
understanding cells merely antibody producers slowly changing alone concert antibody control outcomes seemingly different diseases cancer rheumatoid arthritis diabetes multiple sclerosis role activation effector immune cells beneficial cancer bad autoimmune diseases immunosuppressive regulatory subsets bregs inhibit autoimmune anticancer responses pathogenic suppressive functions static appear regulated nature strength inflammation although aging increases inflammation changes composition function cells surprisingly little known whether change affects aging associated neurodegenerative disease alzheimer disease analyzing cells cancer autoimmune neuroinflammatory diseases elucidate potential importance aging associated neuroinflammatory diseases
work crossroads educational adaptive hypermedia competency based approach adaptive hypermedia systems ahs based domain model learner model provide virtual hypermedia learner achieve interconnection domain representation virtual hypermedia different techniques used particularly interested technique direct relationship allows building structure virtual hypermedia associating concept discipline one physical pages virtual hypermedia one hand hand semantic links discipline concepts corresponds hyperlinks virtual hypermedia ahs already proven usefulness context self learning subject knowledge case objective based pedagogies propose use context self learning disciplinary competencies indeed suggest ahs generates guide map disciplinary competencies connected concepts study according semantics discipline defined domain ontology background disciplinary knowledge base learner profile last deduced learner model put mainly three classes parameters cognitive ones define state knowledge particularly respective performance level competency resolved problem situation type intelligence defines learning style preferences identification parameters disciplinary competencies domain ontology used generate ahs domain designed around main concepts disciplinary composed competency disciplinary elementary granular competency contextualized problem situation potential obstacles potential instructions also semantic relations including prerequisite relationship composition one prototype developed test feasibility dynamic generation guide map case first level relational databases learning knowledge base generated proposed domain ontology prototype tested group students university results interesting
several natural agents causing extensive damages roads landslides claim major destroyer several causes landslides hazardous ground conditions landform configuration adversities occasionally occurring natural physical forces anthropogenic impact environment vulnerable situations top soil hill slopes get disintegrated due intensive precipitation shaking due tremors eventually flows rapidly slope situation deserves search biocover reduce velocity overland flow entrap detached soil particles thereby controlling top soil loss jute geotextile jgt properly designed fulfill said criteria besides facilitating growth vegetation paper discusses optimization property parameters open weave jute geotextile tune different parameters design concerning protection hill slope along comparative analysis results different tests one hand determination tolerance limit prime property parameters developed jgt samples employed different case studies prove potentiality technoeconomic viability
outreach schools important attracting students electrical engineering circuits kits provide students hands interactions electrical circuits goal experimental study investigate effects two types electrical circuit element representations self reported perceptions outreach activity learning elementary high school students abstract representation type circuit elements marked standard engineering symbols concrete representation type circuit elements batteries light bulbs familiar students perceived student enjoyment understanding cognitive load assessed surveys student learning measured post test impacts student gender developmental level also analyzed results indicate elementary school students concrete representation led higher understanding ratings lower cognitive load ratings abstract representation difference student learning two representation conditions high school students significant differences student perceptions learning two representation conditions however male high school students gave significantly higher interest understanding ratings well lower cognitive load ratings female counterparts even though significant difference student learning genders elementary school students reported higher enjoyment circuits kit activity higher cognitive load high school students
ovarian protection chemotoxicity essential reproductive health objective determine role atp dependent multidrug resistance transporters mdrs protection previously identified mdr dependent cytoprotection cyclophosphamide mouse human oocytes use mdr inhibitors use genetic deletions mdra bcrp mice test mdr function ovarian somatic cells find mdra bcrp mice significantly increased sensitivity cyclophosphamide estrus cyclicity follicle distribution mdrl bcrp mice also differed age matched wildtype ovaries found mdr gene activity cycles estrus mdr cyclicity correlated beta estradiol surges also examined metabolite composition ovary learned mdrl alb bcrp mice increased accumulation metabolites indicative oxidative stress inflammation conclude mdrs essential ovarian protection chemotoxicity may important physiological role ovary elsevier inc rights reserved
distinguished career regents professor karsten schwan made significant contributions across diverse array topics computer systems including operating systems multi core platforms virtualization technologies enterprise middleware high performance computing paper summarize legacy key research contributions general purpose gpu computing vision encompassed conceptualization implementation demonstration systems abstractions runtime methods elevate gpus first class citizens today future heterogeneous computing environments end contributions include novel scheduling resource management abstractions runtime specialization novel data management techniques support scalable distributed gpu frameworks
course time hepatitis become universal health menace deleterious effects human liver encompass lot physiological genetic well epigenetic alterations fatty liver hepatic steatosis inflammation multifactorial ancestries one hcv steatohepatitis hcv boosts several cellular pathways involving regulation number cytokines current study reviews regulation selective key cytokines hcv infection help generate improved understanding role cytokines beta tnf alpha ifn inflammatory markers body particular markers along others help hepatocytes viral infestation however recently association found degradation liver trail heading non alcoholic steatohepatitis nash consequently disturbance equilibrium repeatedly reported hcv infection quite number findings affirming regulation although cell markers stimulated hepatocytes standard protection mechanism modern studies testified paradoxical nature defense line nevertheless direct molecular epigenetic research needed question actual molecular progressions directions commanding liver steatosis cirrhosis eventually hcc hepatocellular carcinoma
past years new era smart connected devices emerged market enable future world internet things iot key requirement iot applications power consumption allow high autonomy case battery powered systems depending application devices time low power mode sleep mode wake task accomplish active mode emerging non volatile memory technologies seen attractive solution design ultra low power systems among technologies magnetic random access memory promising candidate combines non volatility high density reasonable latency low leakage integration non volatility new feature memories great potential allow full data retention complete shutdown fast wake time article explores benefits non volatile processor enable ultra low power iot devices
past years many representations time series proposed main purpose dimensionality reduction support various algorithms domain time series data processing however transformation algorithms directly applicable streams data static collections data iterative nature work propose symbolic representation time series along method transformation time series data proposed representation one basic requirements applicable representation distance measure would accurately reflect true shape data propose distance measure operating proposed representation lower bounding euclidean distance original data evaluate properties proposed representation distance measure ucr collection datasets focus stream data processing evaluate properties limitations proposed representation long time series domain electricity consumption monitoring simulating processing potentially unbound data stream elsevier inc rights reserved
overactive bladder oab idiopathic condition characterized urgency urinary frequency urgency incontinence absence routinely traceable urinary infection described microscopic pyuria wbc patients suffering worst symptoms established inflammation associated increased atp release epithelial cells extracellular atp originating urothelium following increased hydrostatic pressure mediator bladder sensation using bladder biopsy samples investigated urothelial atp signaling oab patients microscopic pyuria basal stretch evoked release atp significantly greater urothelium oab patients pyuria non oab patients oab patients without pyuria wbc basal atp release urothelium oab patients pyuria inhibited receptor antagonist suramin abolished hemichannel blocker carbenoxolone differed stretch activated atp release altered receptor expression evident urothelium pyuric oab patients furthermore intracellular bacteria visualized shed urothelial cells similar oab patients pyuria data suggest increased atp release urothelium involving bacterial colonization may play role heightened symptoms associated pyuric oab patients
oxygen reduction reaction orr core various applications fuel cells metal air batteries electro generation depending targeted application catalysts follow direct four electron pathway two electron pathway envisaged systematically investigated impact electrocatalyst loading rotating ring disk electrode rrde activity selectivity towards orr alkaline medium koh four representative catalysts including noble metal catalyst commercial etek metal free catalysts printex carbon black graphene non noble metal catalyst selected exhibit different behaviours orr following direct four electron pathway two electron pathway series pathway results confirmed catalyst loading influences activity selectivity catalysts lower loadings favoring electrogeneration researchers pay attention moreover order make possible comparison results coming different research groups recommend reasonable loading ranges type catalyst elsevier rights reserved
ionotropic non selective cation channels expressed throughout kidney activated paracrine autocrine manner following binding extracellular atp related extracellular nucleotides whilst wealth literature describing regulatory role receptors kidney significantly less data regulatory role receptors pxr compared described metabotropic much historical literature describing role pxr kidney focused heavily role autoregulation renal blood flow recently however plethora manuscripts providing compelling evidence additional roles pxr kidney health disease review summarizes current evidence involvement pxr regulation renal tubular vascular function highlights novel data describing putative roles regulating physiological pathophysiological processes kidney
padmanabhan emergent cosmic space proposal exploited study rastall theory involves modifying covariant conservation law energy momentum tensor necessary elements approach firstly find komar energy general entropy apparent horizon theory modified expansion law invoked obtain friedmann equations
paleokarst commonly expressed subtle stratigraphic surfaces rather large void systems penetrating deeply paleo subsurface contrast regional precambrian cambrian unconformity victoria island nwt canada associated exceptional exposure large intact cambrian paleocavems diameter tens high paleocaves distributed along paleo horizontal plane associated gryke network present neoproterozoic dolostone cave rooves base overlying cambrian sandstone filled cambrian sandstone formation preservation karst features require aggressive dissolution along stable paleo water table shortly transgression deposition shallow marine sand dolostone transgression karst network acted conduit flowing groundwater discharged overlying unconsolidated cambrian shallow marine sand producing water escape structures sand volcanoes conduits conduits preserved cylindrical remnants sand volcanoes feeder pipes sediment fluidisation probably caused variations hydraulic head gradient meteoric lens near cambrian coastline tropical climate abundant probably seasonally variable rainfall caused pulses subsurface fluid flow spatial distribution paleocaves sand volcanoes suggests formation southeast side recently faulted horst proterozoic carbonate bedrock formed nearshore island early cambrian sea level rise fluidisation structures reported generally difficult interpret owing lack data fluid hydraulics underlying aquifer first report linking hydraulics well characterised paleokarst development fluid escape structures structures widely known sandstones overlying sub cambrian unconformity around circumference laurentia elsevier rights reserved
palm oil mill effluent pome rich organic matter one major contributors water pollution date biological treatment employed released water bodies minimize environmental hazards however dark brownish colour effluent still big challenge addressed regard concern membrane separation serve attractive solution issue paper aims investigate performance ultrafiltration nanocomposite membrane embedded coupled zinc iron oxide zio decolourization pome zio synthesized solution combustion technique employing zinc nitrate hexahydrate iron iii nitrate nonahydrate precursors urea fuel nanocomposite flat sheet membrane prepared via phase inversion process physico chemical properties mmms analysed using zeta potential analysis sem bet contact angle continuous filtration test carried evaluate capability mmms colour cod removal results showed increase zio loading drastically increased membrane surface negativity led colour removal addition addition permeation colour removal increased respectively compared pristine pvdf membrane however long term filtration test revealed structure collapsed cycles washing still retained performance nutshell study demonstrated negative surface charge improved antifouling properties meanwhile hydrophilicity contributed increased water flux colour removal process elsevier rights reserved
parabolic trough collectors ptc provides thermal solar energy medium temperature order increase thermal level solar system coupled upgrading devices absorption heat transformers aht paper feasibility analysis ptc system operating thermal source aht described ptc aht units tested based experimental data system heat transfer analysis carried order propose single system two case studies analysed first evaporator temperature close generator temperature degrees respectively simultaneous flow heat source used second case evaporator temperature lower generator temperature degrees respectively serial flow heat source proposed results show absorber temperature calculated generator evaporator heat loads respectively case components case case ptc system required order provide two mass flows generator evaporator case one mass flow generator evaporator must satisfied ptc system elsevier ltd rights reserved
parallel bodies research described diverse complex ways men understand construct masculine identities often termed masculinities separately adherence traditional notions masculinity places men risk negative sexual health outcomes goal analysis bring together two streams inquiry using data national online sample heterosexually active young men employed latent class analysis lca detect patterns masculine identities based men endorsement behavioral attitudinal indicators dominant masculinity including sexual attitudes behaviors lca identified four conceptually distinct masculine identity profiles two groups termed normative normative male activities groups respectively constituted sample characterized low levels adherence attitudes sexual scripts behaviors consistent dominant masculinity differed levels engagement male oriented activities sports teams eight percent sample comprised masculinity profile consistent traditional ideas masculinity group labeled misogynistic high levels sexual assault violence toward female partners remaining four percent constituted sex focused group characterized high numbers sexual partners relatively low endorsement indicators traditional masculinity follow analyses showed small number differences across groups sexual substance use health indicators findings implications sexual behavioral health interventions suggest young men embody endorse rigidly traditional forms masculinity
parallel computing useful technology scientific engineering algorithms applications sgs lower upper symmetric gauss seidel method efficient robust scheme cfd computational fluid dynamics strong data dependence computation paper present efficient wavefront parallel algorithm three dimensional sgs structured meshes corresponding data structure memory access method better data locality communication optimization designed performances presented parallel algorithm reported different problem sizes discussion performance issues also reported results show overall performance speedup one intel cpu cpu cores ranges compared one core parallel efficiency processes compared processes distributed memory cluster system cfd simulation wing model shows effect presented parallel algorithm elsevier ltd rights reserved
parallel computing widely utilized speed automatic test pattern generation atpg however today parallel atpgs non deterministic often leads non reproducible test pattern sets paper presents fault parallel test pattern generator cpp atpg generates test pattern set regardless thread count timing besides exhibits good speedup scalability thread count increases achieved circular pipeline processing cpp principle guides proposed parallel atpg preserve task processing orders necessary ensure atpg determinism low inter thread synchronization overhead furthermore multi round test generation compaction strategy proposed avoid possible test pattern inflation experimental results show cpp atpg exhibits close linear speedup least threads
parameter identification important widely used process across field biomedical engineering however susceptible number potential difficulties parameter trade causing premature convergence non optimal parameter values proposed dimensional reduction method drm addresses issue iteratively reducing dimension hyperplanes trade occurs running subsequent identification processes within hyperplanes drm validated using clinical data optimize parameters widely used bergman minimal model glucose insulin kinetics well silico data optimize parameters pulmonary recruitment model results compared popular levenberg marquardt lmq algorithm using monte carlo methodology methods afforded equivalent computational resources drm converged lower equal residual value tests run using bergman minimal model actual patient data model drm attained significantly lower overall median parameter error values lower residuals vast majority tests shows drm potential provide better resolution optimum parameter values variety biomedical models significant levels parameter trade occur elsevier inc rights reserved
parametric implicit methods traditionally thought two irrelevant approaches structural shape optimization parametric method works lagrangian approach often uses parametric boundary representation rep curves surfaces example bezier splines combination conformal mesh finite element model implicit method relies upon level set functions implicit functions rep works eulerian approach combination fixed mesh within scope extended finite element method finite cell method original contribution work unification methods first new shape optimization method proposed combining features parametric implicit reps shape changes structural boundary governed parametric rep fixed mesh maintain merit computer aided design modeling avoid laborious remeshing second analytical shape design sensitivity formulated parametric rep framework fixed mesh finite cell method means hamilton jacobi equation numerical examples solved illustrate unified methodology copyright john wiley sons ltd
parathyroid carcinoma rare malignancy usually occurs sporadic disease less frequently setting genetic syndromes despite association parathyroid thyroid disorders quite common coexistence parathyroid carcinoma thyroid disease rare reviewed pertinent literature terms parathyroid carcinoma thyroid disease hyperthyroidism thyrotoxicosis hypothyroidism thyroid nodule graves disease autonomously functioning thyroid nodules used separately reciprocal conjunction search medline articles published january march search prompted observation never reported association autonomously functioning thyroid nodules parathyroid carcinoma two hundred twenty one parathyroid carcinoma patients described last years neck ultrasonography parathyroid scintigraphy common instrumental studies used detecting parathyroid lesions serum parathyroid hormone calcium levels high majority parathyroid carcinoma patients patients parathyroid carcinoma thyroid disorders found patient first casual association parathyroid carcinoma autonomously functioning thyroid nodules reported literature diagnosed using parathyroid thyroid scintigraphies parathyroid carcinoma rare endocrine tumor association thyroid disease frequent parathyroid carcinoma pre operative diagnosis often difficult also available literature data homogenous common operative guideline case confirms role parathyroid scintigraphy encouraging association thyroid scintigraphy especially presence multi nodular goiter order address appropriate surgical management
parental depressive symptoms important public health concern linked numerous previous studies negative parenting behaviors including dysfunctional discipline child abuse neglect taking consideration parental depressive symptoms warrant particular attention among families child maltreatment allegations group high risk dysfunctional discipline future physical abuse current study sought examine relations parental depressive symptoms dysfunctional discipline ethnically diverse sample families referred psychological services due concerns child maltreatment referrals made school medical child welfare personnel children male average age years results indicated parental depressive symptoms significantly correlated dysfunctional discipline including laxness reactivity hostility however three relations lost statistical significance controlling parental stress findings study suggest well documented relations parental depression negative parenting behavior may driven elevated parental stress rather reflecting risks uniquely associated depressive pathology
parental maltreatment children steadily increasing korea despite national efforts curb children adolescents experience maltreatment develop psychological social maladjustment therefore mediating variables alleviating negative effects parental maltreatment child development investigated develop effective intervention programs identified direct effects parental abuse neglect adolescents school adjustment mediating effects adolescents self esteem peer attachment relationships parental abuse neglect school adjustment used data middle school students participated korean children youth panel survey structural equation modeling revealed following child neglect directly negatively related adolescents school adjustment whereas child abuse adolescents self esteem peer attachment mediated relationship child neglect school adjustment adolescents self esteem alone mediated relationship child abuse school adjustment findings imply need develop different intervention programs based child maltreatment types finally suggested negative effects parental neglect adolescents school adjustment could alleviated adolescents self esteem recovery resulting peer support hand case adolescents experiencing parental abuse self esteem recovery education counseling provided teachers respected adults could prioritized
parental practices beliefs recognized important influence development children self regulation using mixed methods approach present study explored parental practices beliefs influence low income mexican american children self regulation fall preschool quantitative results indicated family learning environment parental control significantly related stronger self regulation mexican american children low income families qualitative interviews indicated respect well educated emerged key factors guiding parents expectations children behaviors discipline additionally results indicated parents struggled provide additional educational materials enrich home learning environment children study highlights importance understanding parental practices beliefs low income mexican american parents influence children self regulation better serve needs mexican american parents children
parenting programs currently treatment choice behavioral disorders children one main components reducing negativity bias child parent dyad rational positive parenting program rppp program special focus parent emotion regulation functional reappraisal strategies recently received consistent support reducing child externalizing internalizing disorders last years online interventions proliferated attention bias modification abm becoming promising implicit therapeutic intervention based attention deployment emotion regulation strategy adjunctive module usual treatments results multiple domains varying pain self esteem emotional disorders anxiety conducted two studies investigate efficacy abm procedures applied parents efficacy online version rppp augmented abm module total parents children aged years old participated first study allocated either abm training wait list positive results reported parents participating abm group distress satisfaction positive interactions child child strengths second study parents children allocated either rppp group rppp abm group results show abm training boost effects rppp strengths children reported parents intervention findings discussed light limited research using online tools coaching effective emotion regulation strategies parents
parkinson disease complex neurodegenerative disorder multifactorial pathologies including progressive loss dopaminergic neurons oxidative stress mitochondrial dysfunction increased monoamine oxidase mao enzyme activity currently agents approved ameliorate symptoms however agent able reverse progression disease due multifactorial pathologies necessary develop multifunctional agents affect one target involved disease pathology designed synthesized series new multifunctional anti parkinson compounds protect cerebral granular neurons methyl phenylpyridinium mpp insult scavenge free radicals inhibit monoamine oxidase mao cholinesterase che activities among exhibited potent mao inhibition vitro vivo investigated neuroprotective effects using methyl phenyl tetrahydropyridine mptp induced mouse model vivo alleviated mptp induced motor deficits raised striatal contents dopamine metabolites restored expression tyrosine hydroxylase number positive neurons substantia nigra additionally enhanced expression bcl decreased expression bax caspase activated akt nrf signaling pathway findings suggest may novel therapeutic candidate treatment
parkinson disease frequent neurodegenerative process old age accumulation aggregation lipid binding snare complex component alpha synuclein snca underlies vulnerability defines stages disease progression determinants snca levels mechanisms snca neurotoxicity intensely investigated view physiological roles snca blood modulate vesicle release studied blood samples new large pedigree snca gene duplication park mutation identify effects snca gain function potential disease biomarkers downregulation complexin cplx mrna correlated genotype expression parkinson disease genes global rna seq profiling blood presymptomatic park indviduals bioinformatics detected significant upregulations platelet activation hemostasis lipoproteins endocytosis lysosome cytokine toll like receptor signaling extracellular pathways park platelets stimulus triggered degranulation impaired strong spp gzmh pltp mrna upregulations validated park analysing individuals rapid eye movement sleep behavior disorder specific known prodromal stage general blood cplx levels altered validation experiments confirmed inverse mutual regulation snca cplx mrna levels utr cplx gene identified single nucleotide polymorphism significantly associated risk summary data define cplx risk factor provide functional insights role regulation blood snca levels new blood biomarkers park turkish family might become useful prediction
parkinson disease heterogeneous neurodegenerative disorder variable clinicopathologic phenotypes underlying neuropathologicmechanisms clinical phenotype unique set motor symptoms tremor themost frequent initial motor symptom difficult symptom treat dentate nucleus deep ironrich nucleus cerebellum may involved tremor study test hypothesis iron may elevated tremor dominant patients using quantitative susceptibility mapping forty three patients tremor dominant akinetic rigidity dominant healthy gender age matched controls recruited multi echo gradient echo data collected subject system inter group susceptibility differences bilateral investigated correlations clinical features susceptibility also examined contrast dominant group group found increased susceptibility bilateral compared healthy controls addition susceptibility positively correlated tremor score drug naive patients findings indicate iron load within may make important contribution motor phenotypes moreover results suggest dominant phenotypes differentiated basis susceptibility least group level copyright john wiley sons ltd
parkinson disease progressive neurodegenerative disorder basal ganglia patients suffer somatomotor oculomotor disorders oculomotor system facilitates obtaining accurate information visual world target moves slowly fronto parallel plane tracking eye movements occur consist primarily smooth pursuit interspersed corrective saccades efficient smooth pursuit requires appropriate target selection predictive compensation inherent processing delays although pursuit impairment latency prolongation low gain eye velocity target velocity well known normal aging alone results changes article first briefly review basic features smooth pursuit review recent results showing specific nature impaired pursuit using cue dependent memory based smooth pursuit task task initially used monkeys separate two major components prediction image motion direction memory movement preparation neural correlates examined major pursuit pathways patients possessed normal cue information memory extra retinal mechanisms pursuit preparation execution dysfunctional minority patients abnormal cue information memory difficulty understanding task patients normal cue information memory changed strategy initiate smooth tracking strategy changes also observed compensate impaired pursuit whole body rotation target moved head discuss pathophysiology comparing eye movement task results neuropsychological motor symptom evaluations individual patients monkey results suggest possible neural circuits functions dysfunctions
parkinson disease one prevalent neurodegenerative disorders elders sesamin lignan compound active constituent sesame oil antioxidant anti inflammatory properties study carried explore mechanisms underlying sesamin effect unilateral striatal hydroxydopamine ohda model intrastriatal ohda lesioned rats pretreated sesamin doses day one week sesamin dose attenuated motor imbalance narrow beam test lowered striatal level malondialdehyde mda reactive oxygen species ros improved superoxide dismutase sod activity lowered striatal caspase activity alpha synuclein expression attenuated glial fibrillary acidic protein gfap immunoreactivity depressed nigral neuronal apoptosis prevented damage dopaminergic neurons using tyrosine hydroxylase immunohistochemistry findings reveal reversal effect sesamin ohda model via attenuation apoptosis astrogliosis oxidative stress regulation alpha synuclein elsevier masson sas rights reserved
parkinson disease characterized late onset progressive dopamine neuron loss movement disorders progresses affected neural function integrity date researches largely addressed dopamine replacement therapies appearance dopa induced dyskinesia hampered use drug mechanism complicated hard solve problem add drugs researchers began focus genetic underpinnings parkinson disease searching new method may affect neurodegeneration processes paper reviewed current delivery methods used gene therapies also summarized primary target gene therapy treatment like neurotrophic factor regeneration synthesis neurotransmitter prolong duration dopa potential proteins might target modulate via gene therapy finally discussed rna interference therapies used parkinson disease might act new class drug mainly focus efficiency tooling features different gene therapies treatment
parkinson disease neurodegenerative disorder accompanied various non motor symptoms including depression anxiety may precede onset motor symptoms selegiline irreversible monoamine oxidase mao inhibitor widely used treatment major depression however reports effects selegiline non motor symptoms aim study explore antidepressant anxiolytic effects selegiline using bst knockout mouse related genetic model displaying depression anxiety compared antiparkinsonian drugs antidepressant investigate effects selegiline biochemical parameters emotion related brain regions single administration selegiline dose dependently reduced immobility time forced swimming test fst mice cbl wild type mice selegiline significantly increased climbing time mice single administration antiparkinsonian drugs pramipexole dopamine receptor agonist rasagiline another mao inhibitor repeated injections noradrenergic specific serotonergic antidepressant nassa mirtazapine also decreased immobility time increase climbing time mice antidepressant like effects selegiline comparable rasagiline tended stronger rasagiline fst mice showed decreases striatal hippocampal serotonin content cortical norepinephrine content plasma corticosterone concentration single administration selegiline returned striatal cortical plasma corticosterone levels observed mice open field test oft repeated administration mirtazapine anxiolytic effects selegiline nonsignificantly ameliorated anxiety like behaviors mice social interaction preference tests repeated mirtazapine ameliorated high anxiety low sociability mice whereas selegiline results indicate selegiline antidepressant mild anxiolytic effects mice suggest effective antiparkinsonian drug depressive anxiety symptoms patients single nucleotide polymorphism snp
parkinson disease growing threat ever ageing population despite progress understanding molecular cellular mechanisms underlying disease therapeutics currently available act improve symptoms stop disease process therefore imperative effective drug discovery methods approaches developed validated used discovery disease modifying treatments parkinson drug repurposing recognized equally promising novo drug discovery field neurodegen eration parkinson disease specifically work utilize transgenic drosophila model parkinson disease made expressing human alpha synuclein drosophila brain validate two repurposed compounds astemizole ketoconazole computationally predicted ameliorative effect parkinson disease neither tested using vivo model disease treating flies parallel results showed drugs rescue motor phenotype developed drosophila model age ketoconazole treatment reversed increased dopaminergic neuron death also observed models hallmark parkinson disease addition validating predicted improvement parkinson disease symptoms drugs revealing potential neuroprotective activity ketoconazole results highlight value drosophila models parkinson disease key tools context vivo drug discovery drug repurposing prioritization hits especially coupled computational predictions
parkinson disease characterized presence insoluble neurotoxic aggregates amyloid fibrils intrinsically disordered protein alpha synuclein study examined effects four naturally occurring polyphenols combination beta cyclodextrin beta aggregation synuclein presence macromolecular crowding agents results reveal even sub stoichiometric concentrations individual components polyphenol beta combination inhibited aggregation proteins also effective disaggregating preformed fibrils curcumin found efficient followed baicalein epigallocatechin gallate resveratrol coming next latter two exhibiting similar effects results suggest efficiency curcumin results balanced composition phenolic groups benzene rings flexibility latter ensures proper positioning functional groups maximize underlying interactions monomeric form alpha synuclein aggregates uniqueness beta reinforced observation none cyclodextrin variants alpha beta used effective spite possessing better water solubility moreover fact combinations remained effective conditions macromolecular crowding suggests potential developed viable drug compositions near future mtt assays cell viability independently confirmed hypothesis wherein combinations polyphenols alone appreciably impeded toxicity prefibrillar alpha synuclein aggregates mouse neuroblastoma cell lines cells elsevier rights reserved
parkinson disease second prevalent neurodegenerative disorder main neuropathological hallmarks disease degeneration dopaminergic neurons substantia nigra pars compacta accumulation protein inclusions known lewy bodies recently great attention given study genes associated familial sporadic forms parkinson disease among alpha synuclein gene believed play central role disease therefore one studied genes parkinson disease complex disorder derives interaction genetic environmental factors offer update landscape epigenetic mediated regulation gene expression linked alpha synuclein associated parkinson disease also provide overview epigenetic modifications influence transcription translation alpha synuclein gene hand synuclein function dysfunction per affect epigenetic landscape finally discuss deeper understanding epigenetic profile alpha synuclein may enable development novel therapeutic approaches parkinson disease synucleinopathies
partial complete division parietal bones resulting anomalous cranial sutures rare entity may raise concern fracture potential abuse identified radiological examination young children present case week old male found anomalous intraparietal sutures originally interpreted fractures comprehensive evaluation nonaccidental trauma goal raise awareness complex branching pattern accessory intraparietal sutures previously described additionally review characteristics aid radiologic differentiation accessory cranial sutures fractures elsevier inc rights reserved
participation sports may influence negative body image social physique anxiety spa pressure significant others certain body image aim present study examine possible differences spa perceived pressure thin female preadolescent adolescent ballet dancers rhythmic gymnastics swimming athletes predict spa global self esteem pressure thin bmi training age study participated ballet dancers rhythmic gymnastics athletes swimming athletes completed self reported questionnaires assessing spa perceived pressure thin coaches parents friends global self esteem body image significant differences groups spa global self esteem perceived pressure thin rates body image hierarchical linear regression showed spa predicted significantly global self esteem bmi seems similarities ballet dancers rhythmic gymnastics athletes swimming athletes although ballet considered non competitive physical activity intervention programs order reduce spa enhance global self esteem addressed group
participatory approaches elicit information multiple stakeholders planning implementing resource management systems elicited information often associated significant variability public participation geographical information science gis gis solutions reduce variability helping stakeholders measure factors involved provide elicited information propose quality function deployment based participatory framework developing gis solutions demonstrated using case study enhance existing gis solution rainwater harvesting systems indian villages novelty proposed framework identifies metrics carries comparative analysis three existing solutions participatory rural appraisal participatory mapping gis case study gis scored less participatory mapping scored less usability affordability improve gis aspects easy use mobile web based free open source gis solution watershed gis developed scored better three existing solutions usage resulted substantial reduction variability criteria values thus better ranking alternatives average coefficient variation decreasing
particle image velocimetry piv matured flow measurement technique enables description instantaneous velocity field flow analyzing particle motion obtained digitally recorded images correlation based piv evaluation technique widely used good accuracy robustness although successful correlation piv technique weakness avoided optical flow based piv algorithms present optical flow methods applied piv based brightness constancy assumption however factors flow imaging technology nature property fluids make brightness constancy assumption less appropriate real piv cases paper implementation optical flow algorithm gcof based gradient constancy assumption introduced proposed gcof assumes edges illuminated piv particles constant motion comprises two terms combined local global gradient data term first order divergence vorticity smooth term approach provide accurate dense motion fields approach tested synthetic images two experimental flows comparison gcof optical flow algorithms indicates proposed method accurate especially conditions illumination variation comparison gcof correlation piv technique shows proposed gcof advantages preserving small divergence vorticity structures motion field getting less outliers consequence gcof acquire accurate better topological description turbulent flow
particulate formation due combustion wide range ethanol gasoline blends investigated internal combustion engine engine used study single cylinder research engine architecture representative modern spark ignited direct injected sidi engine instead direct injection engine fueled using premixed prevaporized pmpv mode supplied fuel engine well mixed gas phase air fuel mixture order isolate physical effects fuel created completely homogenous air fuel mixture pockets significantly differing equivalence ratio liquid fuel droplets wetted surfaces ensuring particulate formation due homogenous gas phase combustion engine operated fixed load phasing effects varying equivalence ratio ethanol content could examined results work show addition ethanol results consistent decrease engine particulate proportional ethanol content moreover critical equivalence ratio equivalence ratio significant sooting begins increases linear fashion ethanol addition also shown shape particulate size distribution psd affected ethanol content increased ethanol leading nucleation mode dominated distributions author published elsevier ltd
particulate matter combined meteorological factors cause haze brings inconvenience people daily life deeply endanger people health accumulating literature date reported closely related cardiopulmonary disease outpatient visits admissions result asthma heart attacks gradually increase elevated concentration owing special physicochemical property brain could potential target beyond cardiopulmonary system possible routes brain via direct route stimulation pro inflammatory cytokines reported several documents concerning toxicity engineered nanoparticles rodents recent studies demonstrated implications oxidative stress inflammation dysfunction cellular organelles well disturbance protein homeostasis promoting neuron loss exaggerating burden central nervous system cns moreover smallest particles nano sized particles involved inflammation reactive oxygen species ros microglial activation neuron loss may accelerate process neurodevelopmental disorder neurodegenerative disease potential undiscovered mechanisms mutually exclusive complementary aspects epidemiology studies shown exposure could bring neurotoxicity play significant role etiology cns disease gradually corroborated vivo vitro studies review highlights research advances health effects emphasis neurotoxicity hope enhancing awareness public calling prevention protective measures critical topic requires proceeding exploration copyright john wiley sons ltd particulate matter combined meteorological factors cause haze deeply endanger people health due special physicochemical property brain could potential target beyond pulmonary system reported particular smallest particles nano sized particles involved neural developmental disorder neurodegenerative disease chronic vicious circulation called reactive microgliosis astrogliosis may potential mechanism review highlighted research advances health effect emphasis neurotoxicity
partitionfinder program automatically selecting best fit partitioning schemes models evolution phylogenetic analyses partitionfinder substantially faster efficient version incorporates many new methods features include ability analyze morphological datasets new methods analyze genome scale datasets new output formats facilitate interoperability downstream software many new models molecular evolution partitionfinder freely available open source license works windows osx linux operating systems downloaded www robertlanfear com partitionfinder source code available https github com brettc partitionfinder
party members college students outstanding students well builders successors socialism main task party construction among college students cultivate talents cultivate high quality talents knowledge ability belief party country therefore implementing party construction work among college students better way ensuring cultivation quality party members college students direct relationship development future career country party construction work among college students effective way improving ideological political work college students new trend standardize organization development program form kinds statements make auxiliary analysis strengthen active consciousness party spirit exercise among students adoption student party construction management office automation system improve scientific level student party construction work colleges universities
past research demonstrated perceivers likely draw spontaneous trait inferences stis stereotype consistent behaviors stereotype inconsistent behaviors four studies conducted examine moderating role power stereotype effects stis priming power using scrambled sentence task study found high power participants drew stis elderly stereotype consistent elderly stereotype inconsistent sentences low power participants draw stis elderly stereotype consistent stereotype inconsistent behaviors study replicated findings study exploring moderating role power gender stereotype effects stis measuring participants dispositional power via personal sense power study found dispositional power also moderated effects gender stereotype stis study found compared baseline condition nopower manipulation low power condition inhibited stis stereotype consistent behaviors high power condition facilitate sti formation stereotype consistent behaviors current study first show power influences reliance stereotypes spontaneously inferring traits behaviors
past research proven significant effects game based learning learning motivation academic performance described key factors game based design nonetheless research correlations among learning motivation cognitive load learning anxiety academic performance gamified learning environments minimal study therefore aims develop gamification software engineering education learning system gseels evaluate effects gamification learning motivation cognitive load learning anxiety academic performance applying structural equation modeling sem empirical research questionnaire contains gamification learning scale learning motivation scale cognitive load scale learning anxiety scale academic performance scale total undergraduates two classes participated study structural equation modeling sem analysis includes path directions relationship descriptive statistics measurement model structural model evaluation five variables research results support nine hypotheses research findings also show effects cognitive load learning anxiety strong learning motivation resulting low learning anxiety result proven study well designed gseels would affect student learning motivation academic performance finally relationship model gamification learning learning motivation cognitive load learning anxiety academic performance elucidated four suggestions proffered instructors software engineering education courses research assist instructors application favorable gamification teaching strategies
past research shown individuals low prejudice think carefully information stigmatized individuals non stigmatized individuals one explanation effect heightened scrutiny stems motivation guard potential prejudice toward stigmatized others watchdog motivation present research tested variation watchdog hypothesis based idea implicit ambivalence specifically argue among individuals low explicit deliberative prejudice also relatively high implicit automatic prejudice processing prejudice relevant contexts implicit ambivalence framework also makes novel prediction individuals relatively high explicit prejudice low implicit prejudice would also engage enhanced information processing predicted people racial implicit explicit attitude discrepancies regardless direction discrepancy found engage greater scrutiny message hiring black faculty study message black job candidate study even black concept merely primed subliminally prior reading race irrelevant message study elsevier inc rights reserved
past work suggested dual identity effective reduce prejudice study extended research dual identity prejudice identifying boundary condition relationship group permeability study replicated previous studies chinese individuals found inducing dual identity emphasizing subgroup differences common nation identity compared control condition decreased urban residents prejudice rural urban migrants study manipulated group boundary permeability using hukou system reform found group boundary permeable dual identity effective reducing prejudice rural urban migrants however effect vanished condition group boundary impermeable results point importance inducing dual identity specific conditions research decreasing prejudice practical implications findings urbanization immigration discussed
patarin proposed crytographic trapdoor called hidden field equation hfe trapdoor based multivariate quadratic isomorphism polynomials problems problem proved patarin complete although basic hfe proved vulnerable attacks variants obtained modifications proved stronger attacks quartz digital signature scheme based hfev trapdoor variant hfe particular choices parameters shown stronger algebraic attacks recover private key furthermore generates reasonably short signatures however joux proved based birthday paradox attack quartz malleable sense adversary gets valid pair message signature valid signature another related message obtainable computations queries signing oracle currently recommended minimum security level signature scheme also based quartz achieve security level joux attack also efficient signature verification vector initializations furthermore implemented original improved quartz signature run empirical comparisons
path polymorphism ability define functions operate uniformly arbitrary recursively specified data structures essence captured patterns form decompose compound data structure parts typing kinds patterns challenging since type compound determine type components propose static type system run time analysis pattern calculus captures feature solution combines type application constants types union types recursive types address fundamental properties subject reduction progress guarantee well behaved dynamics results rely crucially notion pattern compatibility also coinductive characterisation subtyping
patient demand aesthetic dentistry steadily growing laminates free metal restorations evolved attempt overcome invasiveness nature full veneer restorations although many different materials used making restorations single material fits best purposes two groups ceramic material feldspathic ips empress one group laboratory composite gradia discs discs group diameter thickness prepared according manufacturer instruction surface ceramic discs etched silanized gradia group liquid primer applied composite surfaces thirty freshly extracted sound human molars premolars randomly divided three groups enamel surface tooth slightly flattened buccal lingual side primed cemented prepared discs aid dental surveyor finishing specimens thermocycled degrees degrees cycles prepared shear bond strength testing resulting data analyzed one way anova tukey hsd test fractured surfaces specimen inspected means stereomicroscope sem significant difference bond strength materials tested mean bond strengths obtained feldspathic ceramic ips empress gradia mpa mpa mpa respectively fracture pattern mainly mixed ceramic groups scientific evidence needed standardization bonding protocols
patient male final diagnosis neurosarcoidosis symptoms fecal incontinence center dot hypothermia center dot loss balance center dot loss consciousness medication clinical procedure specialty family medicine objective unusual clinical course background sarcoidosis systemic disease unclear etiology estimated prevalence cases per population although sarcoidosis primarily affects pulmonary system affects nervous system patients condition case report article describes case neurosarcoidosis primary presenting finding hypothermia year old african american man past medical history significant hypertension asthma anemia presented emergency department found unresponsive home patient found significantly low temperature degrees presentation subsequently diagnosed sarcoidosis mediastinal biopsy revealed non caseating granulomas variable stages sclerosis consistent long standing sarcoidosis subsequent admission patient presented hyperthermia suggesting hypothalamic involvement part neurosarcoidosis conclusions neurosarcoidosis rare variant sarcoidosis varying presentations including headaches seizures ataxia visual disturbances loss sensation neurologic abnormalities presenting case knowledge first report neurosarcoidosis presenting hypothermia aim use teaching moment discussion clinical presentations management patients
patient reported outcome increasingly applied health sciences patients eating disorders eds characteristically different opinion needs health professionals lead ambivalence towards treatment immense compliance difficulties cross sectional study compared data assessed clinician patient reported measures patients history eds included data cohort patients eds referred specialized unit denmark patient reported measures included eating disorder inventory edi short form clinical data included remission status body mass index bmi found positive association bmi edi scores anorexia nervosa eating disorder otherwise specified ednos reflecting increasing symptomatology increasing bmi association observed bulimia nervosa find correlation scores bmi diagnostic groups
patients advanced dementia suffer severe cognitive functional impairment including eating disorders focus research issue life sustaining treatment specifically social ethical implications tube feeding treatment decision based values life dignity involves sustaining lives many people consider worth living explore moral approach caring patients review history debate artificial nutrition hydration showing impact varying perceptions value patients lives changing norms argue light value solidarity decisions life sustaining treatment patients advanced dementia made case case basis patient consideration medical implications intervention might best serve goals care care respect dignity individual patient
patients borderline personality disorder bpd show deficits reward guided decision making learning present study examined risk taking behavior combination feedback processing eighteen bpd patients healthy controls performed probabilistic two choice gambling task electroencephalogram recorded options differed risk identical expected value outcome probability feedback related negativity frn feedback related analyzed healthy controls preferred low risk high risk options whereas bpd patients chose option equal probability frn amplitudes reduced bpd effects feedback valence risk differ groups suggests attenuated outcome processing anterior cingulate cortex intact reward prediction error signaling furthermore modulation feedback related feedback valence risk smaller bpd patients decreased amplitudes associated increased behavioral risk taking behavior findings could relate reduced ability bpd patients learn adequately adjust behavior based feedback information possibly due reduced significance negative feedback elsevier ireland ltd rights reserved
patients hematological cancer high risk invasive fungal diseases ifds infections mostly life threatening early diagnosis initiation appropriate antifungal therapy essential clinical outcome commonly aspergillus candida species involved however non aspergillus molds increasingly identified cases documented ifds important risk factors long lasting granulocytopenia neutrophil counts days graft versus host disease resulting allogeneic stem cell transplantation definite diagnosis ifd various diagnostic tools applied including conventional mycological culture nonconventional microbiological tests antibody antigen molecular tests well histopathology radiology last years various laboratory methods like aspergillus immunoassay aspergillus eia glucan assay polymerase chain reaction pcr techniques developed better diagnosis since single indirect test including radiological methods provides definite diagnosis invasive fungal infection combination different diagnostic procedures include microbiological cultures histological serological molecular methods like pcr together pattern clinical presentation may currently best strategy prompt diagnosis initiation monitoring ifds early start antifungal therapy mandatory clinical diagnostics often provide clear evidence ifd integrated care pathways proposed management therapy ifds either diagnostic driven strategy using preemptive antifungal therapy opposed clinical empirical driven strategy using traditional empirical antifungal therapy antifungal agents preferentially used systemic therapy invasive fungal infections amphotericin preparations fluconazole voriconazole posaconazole caspofungin anidulafungin micafungin recently isavuconazole clinical decision making must consider licensing status local experience availability pharmacological economic aspects
patients inflammatory bowel disease ibd often experience severe impairment different life domains psychological factors illness perceptions coping may play role adjustment ibd indicated mental physical health activity work impairment present study aimed examining assumption common sense model csm coping mediates relationship illness perceptions adjustment patients ibd cross sectional design ibd patients crohn disease male mean age years attending outpatient clinic completed questionnaires assessing illness perceptions ipq coping cors mental physical health well activity work impairment wpai multiple mediation analyses applied allow estimating total direct effects illness perception dimensions indirect effects coping strategies illness outcomes simultaneously analyses yielded significant direct effects perceptions regarding cyclical course chronic course severity consequences comprehensibility emotional impact ibd study outcomes additionally significant indirect effects found perceptions regarding severity consequences possibility personal control comprehensibility ibd mental physical health well activity impairment use one specific coping strategy reduction activity results provide evidence assumptions csm suggest importance addressing illness perceptions activity stimulation quality health care ibd patients
patients polycythemia vera experience shortened survival increased risk thromboembolic hemorrhagic events burdensome symptoms patients treatment aspirin hematocrit control phlebotomy recommended addition patients high risk status poor hematocrit control benefit cytoreductive therapy hydroxyurea although approximately patients develops resistance intolerance patients resistant intolerant hydroxyurea studies shown ruxolitinib janus kinase inhibitor provides hematocrit control reduces spleen size normalizes blood counts improves related symptoms many patients managed community health setting important community hematologists oncologists internists familiar contemporary management improve patient outcomes including management patients present unique health care needs review provides overview current treatment options patients discusses challenging circumstances encountered community providers management including symptom assessment identification hydroxyurea resistance intolerance pregnancy elective surgeries concomitant immunosuppressants managing patients areas limited access specialized hematologic care author published karger basel
patients rheumatoid arthritis experience increased cardiometabolic risk factor burden substantially driven systemic inflammation occurs less consistently patients ankylosing spondylitis psoriatic arthritis strongly associates excess adiposity metabolic risk patients also often systemic inflammation induced proinflammatory high density lipoprotein hdl cholesterol particles lean muscle mass loss association increased adiposity condition termed rheumatoid cachexia enhances cardiovascular risk presence proinflammatory hdl lean mass loss also reported patients individualized aerobic resistance exercise programs improve body composition metabolic risk factor profiles future studies assess long term lifestyle changes effectuated influence cardiovascular events inflammatory rheumatic diseases herein review current evidence metabolic abnormalities inflammatory arthritis propose management strategies research agenda elsevier ltd rights reserved
patients severe asthma represent minority total asthma population carry majority morbidity healthcare costs achieving better asthma control group patients therefore key importance systematic assessment patients possible severe asthma identify treatment barriers triggers asthma symptoms including morbidities improves asthma control reduces healthcare costs recommended international guidelines management severe asthma review provides clinician overview prevalence clinical impact common morbidities severe asthma including chronic rhinosinusitis nasal polyposis allergic rhinitis dysfunctional breathing vocal cord dysfunction anxiety depression obesity obstructive sleep apnoea syndrome osas gastroesophageal reflux disease gerd bronchiectasis allergic bronchopulmonary aspergillosis abpa eosinophilic granulomatous polyangiitis egpa furthermore review offers summary recommended diagnostic management approaches morbidity finally review links morbid conditions specific phenotypes severe asthma order guide clinician morbidities look specific patients
pattern matching fundamental approach detect malicious behaviors information internet gradually used high speed network traffic analysis however performance bottleneck multi pattern matching online compressed network traffic cnt malicious intrusion codes often embedded compressed network traffic paper propose online fast multi pattern matching algorithm compressed network traffic fmmcn fmmcn employs two types jumping jumping sliding window string jump scanning strategy skip unnecessary compressed bytes moreover fmmcn ability efficiently process multiple large volume networks http traffic vehicles traffic internet based services experimental results show fmmcn ignore bytes maximum speed reaches mid range switches device faster current fastest algorithm acch almost
patterns myeloid growth factor usage febrile neutropenia examined patients years age diffuse large cell non hodgkin lymphoma dlbcl enrolled calgb ecog swog receiving initial therapy cyclophosphamide doxorubicin vincristine prednisone chop rituximab chop chop myeloid gfs administered patients indications use prevent dose reduction dose delay treat non febrile neutropenia nfn one episodes occurred patients often cycle episodes multivariate analysis risk factors included age years odds ratio anemia hemoglobin confidence intervals myeloid use common older dlbcl population receiving chop based therapy especially cycle one risk factors predictive used prospectively identify patients myeloid gfs best utilized
pay consume new type cloud computing paradigm become increasingly popular since large number cloud services gradually opening consumers gives consumers great convenience users longer need buy hardware resources confronted deal effectively data cloud improve performance cloud platform consumer centric cloud computing model becomes critical issue existing heterogeneous distributed computing systems provide efficient parallel high fault tolerant reliable services due characteristics managing large scale clusters though latest cloud computing cluster meets need faster job execution effective use computing resources still challenge presently proposed methods concentrated improving execution time incoming jobs shortening mapreduce time paper adaptive scheme offered achieve time space efficiency heterogeneous cloud environment dynamic speculative execution strategy real time management cluster resources presented optimize execution time map phase prediction model used fast prediction task execution time combing prediction model multi objective optimization algorithm adaptive solution optimize performance space time obtained experimental results depict proposed scheme allocate tasks evenly improve work efficiency heterogeneous cluster
pedagogical agents animated avatars stimulate cognitive socio emotive aspects instructional activity virtual learning environment context visual design pedagogical agent simulating human tutor either realistic rendered naturalistic unrealistic rendered stylized cartoon though design factors agent stereotypes aesthetics roles gender studied extensively issue pedagogical agent realism receive sufficient attention research community unfortunate decision regarding agent visual realism must faced instructional designers implementing pedagogical agent virtual learning environment hence objective study investigate relationship among agent visual realism learners cognition learner socio emotive behaviours virtual learning environment one hundred forty four university sophomores asian university interacted either realistic agent rendered naturalistic unrealistic agent rendered stylized cartoon virtual learning system delivers lesson basic computer programming results showed unrealistic cartoonish agent imposed extraneous cognitive load hindered learning transfer particularly male learners mediation analysis demonstrated effects agent design realistic versus cartoonish learning transfer among males fully mediated learner extraneous load hypothesis cartoonish agent elicit higher socio emotive responses learners supported contrary realistic agent induced higher level positive affect learners unrealistic agent theoretical design considerations regarding agents visual realism discussed paper
peer rejection deviant peer affiliation linked consistently development maintenance conduct problems two proposed models may account longitudinal relations among peer processes conduct problems sequential mediation model peer rejection childhood deviant peer affiliation adolescence mediate link early externalizing behaviors serious adolescent conduct problems parallel process model peer rejection deviant peer affiliation considered independent processes operate simultaneously increment risk conduct problems review evaluate theoretical models evidence associations among conduct problems peer rejection deviant peer affiliation consider support sequential mediation parallel process models next propose integrated model incorporating sequential mediation parallel process models future research directions implications prevention intervention efforts discussed
pelvic floor ultrasound plays major role urogynecologic diagnostics using ultrasound identify integrity levator ani measure hiatal area axial plane main goal study measure hiatal area valsalva cohort urogynecological patients furthermore aimed correlate hiatal area urogynecological symptoms levator integrity evaluate cut values pelvic organ prolapse retrospective analysis included patients seen urogynecological problems tertiary urogynecological unit standardized interview physical examination pelvic floor ultrasound performed according cardinal urogynecological symptoms signs patients categorized three groups pelvic organ prolapse stress urinary incontinence overactive bladder symptoms median age study population range years median parity range nulliparous women symptoms overactive bladder common followed symptoms stress incontinence symptoms prolapse examination showed signs prolapse levator avulsions ultrasound detected hiatal area normally distributed median range patients levator avulsion significantly larger hiatal area also patients signs prolapse significantly larger hiatal area correlation hiatal area symptoms overactive bladder although reaching statistical significance evidence smaller hiatal area patients stress incontinence cohort women without ballooning showed mild moderate marked severe ballooning roc curve analysis hiatal area patients prolapse yielded auc using youden index obtained cut sensitivity specificity hiatal area new repeatable diagnostic parameter clinical application could improve understanding pathophysiology pelvic organ prolapse form hiatal hernia
penicillium marneffei marneffei causes systemic opportunistic infections immunocompromised individuals particularly infected human immunodeficiency virus hiv rarely hiv negative patients retrospectively analyzed cases patients infected marneffei patients divided two groups hiv negative hiv positive cases studied three hiv negative six hiv positive group accompanying lung infection ratio hiv negative group hiv positive patients series laboratory examinations performed bone marrow smears observed staining marneffei disseminated fungal infection associated severe disease symptoms high mortality rates findings indicate timely diagnosis treatment clinicians crucial preventing spread localized infections systemic infections thereby improving prognosis patients published elsevier ltd
penicillium marneffei rare invasive fungal infection primarily occurs southeastern eastern regions asia hiv positive individuals herein present rare case disseminated marneffei infection fungemia intestinal perforation hiv negative patient china extensive diagnostic evaluations reveal cause disease use automated microbiology system matrix assisted laser desorption ionization maldi time flight tof mass spectrometry polymerase chain reaction pcr sequencing analysis detect identify pathogen positive blood culture patient pathogen initially misdiagnosed stephanoascus ciferrii automated microbiology system however sequencing analysis revealed pathogen marneffei patient treated amphotericin significant improvement condition achieved however month patient suffered intestinal perforation may caused marneffei although marneffei found select regions appears mostly patients weak immune system particularly hiv positive individuals important note addition patients hiv positive anyone weak immune system infected marneffei dna sequencing generally considered gold standard identification microorganisms
people commonly reference minority friendships expressing conceivably prejudiced attitudes prevalence strategy suggests widespread belief minority friends makes one look less racist date little research demonstrating whether case white asian participants presented facebook profile depicting white target posted anti asian statement depicted asian friends study even verbally claiming asian friends study reduced attributions racism irrespective whether evaluated white asian observers furthermore presence asian friends made conceivably racist comments seem relatively benign observers less offended upset data suggest minority friendships partially offset costs associated expressing prejudice
people give widely varying estimates amount genetic overlap exists humans laypeople believe humans highly genetically similar one another others believe humans share little genetic overlap studies examine beliefs genetic overlap affect neural evaluative reactions racially ambiguous biracial targets study found lower genetic overlap estimates predicted stronger neural avoidance response biracial compared monoracial targets study found lower genetic overlap estimates predicted longer response times classify biracial monoracial faces racial categories study manipulated genetic overlap beliefs found participants low overlap condition explicitly rated biracial targets negatively high overlap condition taken together data suggest genetic overlap beliefs influence perceivers processing fluency evaluation biracial racially ambiguous individuals
people smile social interactions convey different types nonverbal communication however smiling potentially change way person perceived along different facial dimensions including perceived age commonly assumed smiling faces perceived younger faces carrying neutral expression series experiments reported describe unintuitive robust effect opposite direction across different experimental conditions stimulus sets smiling faces consistently perceived older compared neutral face photos persons suggest effect due observer failure ignore smile associated wrinkles mainly along region eyes findings point misconception regarding relationship facial smile perceived age shed new light processes underlying human age perception
people use impressions evaluative target self esteem infer possession socially desirable traits people still use self esteem proxy trait relevant diagnostic information available test possibility two experiments participants learn target person low high self esteem receive diagnostic information target academic success failure positive negative affectivity study watch video target extraverted introverted behavior study experiments participants impressions target traits accurately tracked diagnostic information impressions also revealed independent self esteem proxy effect evidently self esteem proxy robust influences person perception even presence vivid individuating information
people syndrome neurodevelopmentally distinct brain invariably developed amyloid neuropathology age cross sectional study aimed provide detailed account brain morphology changes occuring amyloid neuropathology forty six adults underwent structural amyloid imagingdthe latter using pittsburgh compound pib stratify cohort pib positive pib negative age matched controls underwent structural imaging group differences deep gray matter volumetry cortical thickness studied pib negative people neurodevelopmentally atypical brain characterized disproportionately thicker frontal occipitoparietal cortex thinner motor cortex temporal pole larger putamina smaller hippocampi controls presence amyloid neuropathology brains demonstrated strikingly similar pattern posterior dominant cortical thinning subcortical atrophy hippocampus thalamus striatum observed non alzheimer disease care must taken avoid underestimating amyloid associated morphologic changes due disproportionate size subcortical structures thickness cortex authors published elsevier inc open access article license
people epilepsy prone sedentary compared general population causes inactivity ignorance prejudice overprotection fear shame scientific evidence supporting limitation physical exercise persons epilepsy benefits exercise patients huge positive aspects physical conditioning prevention seizures emotional wellbeing social interaction drug treatment adherence osteoporosis prevention better quality life patients families mind individual characteristics physical exercise prescribed guided available evidence underlies complementary therapeutic effects physical activity large positive results low cost sports regular physical activity standard indication persons epilepsy
people forest interactions protected area debated around world present study evaluates land use pattern diversity utilization forest resources marat longri wildlife sanctuary wls using semi structured interview remote sensing global information system gis techniques study many implications people forest interactions sanctuary promote symbiotic approach dealing biodiversity conservation protected area marat longri wls indispensable forest dwellers subsistence livelihoods result pair wise ranking revealed jhum major threat forest cover followed illegal felling agricultural expansion encroachment collection pressure reduce dependence marat longri wls domestication wild plants agroforestry systems augment food production realize needs forest dwellers
people emotional states often depend emotions others consequently predict responses social interactions affective forecasts contend people predict emotional states others empathic forecasts propose empathic forecasts vulnerable stereotype biases demonstrate stereotypes different emotional experiences race experiment sex groups experiment bias empathic forecasts path modeling studies demonstrates stereotype biased empathic forecasts regarding target individual feel social interaction associated participants affective forecasts feel interaction target person affective forecasts turn predict behavioral intentions social interaction even begins stereotypes therefore indirectly bias affective forecasts first influencing empathic forecasts partly constitute turn potentially biased affective forecasts determine social behaviors
perceived vulnerability disease may defined beliefs personal susceptibility transmission infectious diseases emotional discomfort associated potential disease transmission evaluate beliefs perceived vulnerability disease scale pvd used studies aim study validate pvd questionnaire spanish population sample made university students spain confirmatory factor analysis revealed items short version questionnaire corresponding interrelated two factor model perceived infectability germ aversion showed best fit tested models study scales measure antifat attitudes disgust negative attitudes towards aids used analyse criterion validity pvd questionnaire sample made university students found germ aversion positively related antifat attitudes disgust negative attitudes towards aids light results conclude short version questionnaire good psychometric properties used scientific community measure perceived vulnerability disease
pericytes multi potential stem cells create walls microvessels capillaries terminal arterioles postcapillary venules cells localized basement membrane tightly encircling endothelium frequently mentioned molecular markers pericytes include neural glial antigen beta type platelet derived growth factor receptor pdgfr beta smooth muscle alpha actin alpha sma regulator protein signalling rgs adhesion protein nestin different functions physiological processes assigned pericytes maintaining integrity senescence endothelial cells regulation vascular tone potential differentiate cells probably also involved pathological processes tissues fibrosis review focus participation pericytes process blood vessel formation regeneration skeletal muscle tissue fibrosis strong evidence pericytes participation endothelial homeostasis well pathological conditions fibrosis reveals broad potential therapeutic use cells targeted pharmacological modulation pericytes leading blocking signalling pathways responsible differentiation pericytes myofibroblasts seems promising strategy treatment fibrosis early stages
perinatal hypothyroidism causes serious damage auditory functions essential vocalization development rat pups perinatal hypothyroidism potentially affects development ultrasonic vocalization usv result hearing deficits study examined effect perinatal hypothyroidism development usvs rat pups twelve pregnant rats divided three groups treated anti thyroid drug methimazole mmi via drinking water gestational day postnatal day pnd mmi concentration control group low dose group high dose group birth pups individually separated dam littermates pnds usvs recorded min pnds compared control group low high dose groups exhibited reductions frequency modulated downward usvs pnd however low high dose groups displayed increases number duration amplitude usvs compared control group lower body weights observed low high dose groups control group total thyroxine concentrations plasma dose dependently reduced onset auditory functions appeared pnds thus rat pups unable hear externally produced usvs pnd usvs emitted pnds might spontaneous independent pups littermate emitted usvs developmental retardation vocalization related organs muscles might underlie acoustic alterations usvs pnds greater number duration amplitude usvs pnd hearing onset occurred suggested elevation auditory thresholds occurred result hearing deficits low high dose groups perinatal hypothyroidism appears caused acoustic alterations usv development elsevier rights reserved
periodic maintenance suspension bridge critical safety bridge structure load bridge supported cables inspections main cable hanger important paper propose cable climbing robot enabling convenient safe visual inspection hanger cable robot comprised three identical modules assembled degrees apart circumferentially frame around cable module three functional mechanisms driving adhesion safe landing robot controlled wirelessly operator ground though power supplied via tether cable addition vision sensor consisting three cameras provides images taken three different directions covering cable odometer made soft idler wheel locates robot cable robot able transmit visual images cable surfaces realtime position climbing paper kinematic force analysis robot performed feasibility experimentally demonstrated
peripheral inflammation known trigger neuroinflammation neurodegenerative disease however key components propagation inflammation periphery central nervous system cns remain unclear lipopolysaccharide lps administered sprague dawley rats induce peripheral inflammation intravenous injection intranigral injection clodronate liposomes given deplete monocytes microglia respectively recombinant fusion protein cdfc anti cdr antibody injected substantia nigra manipulate involvement cdr immunohistochemistry immunofluorescence staining used measure microglial activation dopaminergic neuronal loss expression brain pro inflammatory cytokines tumor necrosis factor alpha cdr signaling measured quantitative pcr data showed peripheral lps injection activated microglia induced increase levels pro inflammatory cytokines tumor necrosis factor alpha depletion either monocytes microglia suppressed inflammatory effects induced peripheral lps administration peripheral lps injection increased expression cdr substantia nigra dopaminergic neuronal loss induced peripheral lps injection accelerated blockade cdr signaling anti cdr antibody attenuated intensifying signaling cdfc results highlight importance monocytes microglia cdr signaling transmission inflammation periphery cns
permanent deformation known one critical distresses observed asphalt pavements known depend asphalt binder aggregates voids components asphalt mixture study effort investigate effect asphalt binder modification type aggregate structure rutting resistance experimentation finite element simulation asphalt binders different levels non recoverable compliance jnr elastic recovery based multiple stress creep recovery test selected asphalt mixtures different aggregate gradations prepared testing image processing numerical simulation flow number test conducted mixture samples obtain asphalt mixture rutting performance two dimensional image analysis also conducted mixture samples characterise internal aggregate structures addition recently developed image based multi scale finite element model used predict permanent deformation asphalt mixtures approach four interconnected scales modelled namely asphalt binder mastic mortar mixture scales homogenisation upscaling techniques transfer material properties lower scale higher scale novel approach taking account contact mechanics aggregates function proximity used scales simulation results show changing aggregate gradation packing viscous component asphalt binder jnr rutting resistance asphalt mixtures significantly improved however comparison elastic component asphalt binder recovery found significant factor especially well packed aggregate structure results raise questions focus many agencies requirements elastic recovery binders tool select modified binders better high temperature performance
permeable pavements allow stormwater pass pavement surface filtering sediment debris time regular preventative maintenance needed maintain pavement surface infiltration rate testing commonly used determine maintenance needs frequencies astm standard methods may used measure permeable pavement however tests take hours complete require infiltrometers readily available maintenance contractors simple infiltration test sit devised conducted using easily acquired materials larger surface area representative average pavement conditions requires average less time conduct astm test astm sit methods compared conducting total tests locations permeable pavements north carolina ohio sweden results showed segmented linear relationship related sit astm measured irs sit astm tests predicted approximately min larger surface area sit reduced variability measurements average less compared astm method sit took one quarter time run average making newly devised tool efficient assessing astm methods potentially saving maintenance personnel time money american society civil engineers
peroxisomes involved various metabolic processes important virulence different pathogenic fungi peroxisomes rapidly emerge appressorium fungal infection poorly understood describe gene pef regulate peroxisome formation appressorium controlling peroxisomal fission required plant infection rice blast fungus magnaporthe oryzae targeted deletion pef resulted reduction virulence delay penetration invasive growth host cells pef particularly expressed appressorial development encoding protein localized peroxisomes appressorial development compared massive vesicle shaped peroxisomes formed wild type appressorium delta pef mutant could form stringy linked immature peroxisomes suggesting pef involved peroxisomal fission appressorium formation also found delta pef mutant could utilize fatty acids efficiently improve significantly expression level pef induce peroxisomal fission expected delta pef mutant showed reduced intracellular production reactive oxygen species ros appressorium formation induced ros accumulation host cells infection taken together pef mediated peroxisomal fission important fungal infection controlling number peroxisomes appressorium
personality neuroscience integrates techniques personality psychology neuroscience elucidate neural basis individual differences cognition emotion motivation behavior endeavor pertinent understanding healthy personality variation also aberrant trait manifestations present personality disorders severe psychopathology current review focus advances limitations neuroimaging methods respect personality neuroscience discuss value personality theory means link specific neural mechanisms various traits neural basis big five given overlap dimensional models normal personality psychopathology also describe researchers reconceptualize psychopathological disorders along key dimensions turn formulate specific neural hypotheses extended personality theory examples borderline personality disorder literature used illustrate approach provide recommendations utilizing neuroimaging methods capture neural mechanisms underlie continuous traits across spectrum healthy maladaptive
persons parkinson disease typically susceptible healthy adults impaired performance two tasks dual task interference performed simultaneously limitation many experts attributed limitations cognitive resources nearly studies dual task performance employ walking balance based motor tasks commonly impaired tasks performed using combinaticin one two executive function tasks current study examined whether persons would demonstrate greater dual task effects dtes cognition compared healthy older adults hoas concurrent cycling task participants without completed battery cognitive tasks assessing visual verbal processing following cognitive domains speed processing controlled processing working memory executive function persons exhibited impairments compared healthy participants select tasks back back operation span groups unexpectedly exhibited dual task facilitation response times visual tasks across cognitive domains improved verbal recall executive function task one measure back showed speed accuracy trade dual task results demonstrate paired motor task impaired people exhibit similar dtes cognitive tasks hoas even task effects facilitative generally findings demonstrate pairing cognitive tasks cycling may actually improve cognitive performance may therapeutic relevance cognitive decline associated aging pathology elsevier inc rights reserved
pharmaceutical cognitive enhancement pce represents non medical use prescribed medication improvement cognitive functioning academic performance although studies pce prevalence less clear users non users pce substances differ respect positive negative student experiences academic burnout engagement studies social cognitive variables relate decision making self regulation pce use present study assessed whether students different experiences pce substance use displayed differences academic burnout study engagement social cognitive variables relevant pce use three hundred forty seven university students mean age years females completed battery anonymous questionnaires academic burnout engagement studies social cognitive variables relevant pce use self reported use pce substances non prescribed nutritional supplements three user groups emerged namely non users single users non prescribed dietary supplements dual users non prescribed dietary supplements pce multivariate analysis variance indicated significant differences among three user groups intentions attitudes social norms anticipated regret toward pce use significant differences observed respect academic burnout work engagement findings show university students may engage pce use independent student experiences rather chemically assisted performance enhancement mindset seems differentiate users non users pce substances
pharmacological relevance root hemidesmus indicus herbal drug india traditionally used prevent treat female hormonal disturbance related disorders assuaging symptoms menopausal conditions aim study lack scientific data potential use bone loss present study undertaken investigate effects ethanol extract hemidesmus indicus root osteoporosis ovariectomised rats materials methods thirty wistar female rats randomly divided five groups one group sham operated four groups undergone dorsal ovariectomy ovx four weeks post operative recovery three ovx groups viz group group group treated ninety days standard raloxifene rlx day hemidesmus indicus root extract hire day hire day respectively sham ovx control groups fed equal vehicle volume serum urine biochemistry alkaline phosphatase tartrate resistant acid phosphatase triglyceride total cholesterol calcium phosphorous hydroxyproline weight body uterus vagina femur parameters three point bending tibia fourth lumbar vertebra compression examined furthermore bone architecture uterine hypertrophy examined histopathological studies results application hire increased bone strength restored bone turnover markers alkaline phosphatase tartrate resistant acid phosphatase hydroxyproline moreover improved femur parameters indicated mineralized bones similar results observed raloxifene treatment histopathology studies showed fibrocartilaginous proliferation trabecular bone absence uterine hypertrophy conclusion results strongly suggest hire prevents bone loss ovx induced osteoporosis without estrogen like side effects might potential remedy like raloxifene postmenopausal estrogen deficiency caused osteoporosis
pharmacy required shift toward human service hearing complaints health study help seeking behavior pharmacist really investigated hypothesized decrease expression visibility due pharmacists typical masks may negatively impact help seeker trust pharmacist sample included drugstore customers aged years participants stratified gender randomly assigned two groups evaluation clear masked normal masked pharmacists viewing video either male female pharmacists wearing either clear normal masks participants completed questionnaire primary outcome trust pharmacist measured trust scale secondary outcome impression pharmacist measured nineteen pairs adjectives differences gender trust scores results revealed male female pharmacists wore clear masks rated trustworthy normal masked pharmacists respectively sixteen nineteen adjectives reported pharmacists wearing normal masks indicated greater negative intention clear masks cases among pharmacists wearing clear masks results showed positive correlations trust impression adjective findings indicate pharmacists wearing normal masks partially hide facial expressions may decrease customer trust pharmacist normal masks associated negative impression avoid inhibition help seek behavior recommend pharmacists wear clear mask increase non verbal communication
phase analysis techniques fringe patterns widely used noncontact three dimensional shape deformation measurement fringe projection method recently developed two novel accurate phase analysis methods one two dimensional sampling moire method perform robust phase analysis single shot fringe pattern two dimensional spatiotemporal phase shifting method analyze phase distribution accurately multi step phase shifted fringe patterns perform accurate phase analysis low signal noise ratio conditions two methods use two dimensional discrete fourier transform fast fourier transform therefore algorithms computationally expensive compared conventional one dimensional sampling moire phase shifting methods study fast parallelization implementation two dimensional phase shifting methods including two dimensional sampling moire method spatiotemporal phase shifting method presented utilizing multi core cpu simulation experimental results demonstrate phase analysis reach times faster use core cpu compared single cpu
phase change materials pcms high thermal conductivity efficient solar energy conversion recently attracted much attention however facile strategy enhance thermal conductivity realize energy conversion storage still eagerly desired work low content graphene nano platelets gnp introduced poly ethylene glycol peg boron nitride composite pcm resulting great improvement thermal conductivity photoabsorption ability via facile solution blending process presence gnp contributes enhancing thermal conductivity realizing efficient solar energy conversion including solar thermal solar electric energy conversion peg gnp composite pcms owing formation improved gnp thermally conductive network improvement sunlight harvesting ability respectively thermophysical properties demonstrate compared peg composite pcm content peg gnp composite pcms containing low gnp content maintain comparable energy storage density study sheds light realization solar energy utilization storage organic pcms requiring high thermal conductivity elsevier rights reserved
photocatalytic reduction useful way convert solar energy fuels mimicking artificial photosynthesis gas phase photocatalytic reduction investigated series tio based photocatalysts either bare modified grafting nanoparticles deposition results obtained reaction compared obtained photocatalytic production hydrogen photosteam reforming methanol water mixtures employing photocatalysts series rates two reactions largely depend type photocatalyst exhibit almost parallel behaviour higher photocatalysts containing noble metal nanoparticles however yields products obtained photocatalytic reduction still remain low often decline runs furthermore methane found produced irradiation photocatalysts contacted gas phase containing water vapour carbon dioxide points major role carbon containing impurities photocatalyst surface may act hole scavengers carbon source two step photocatalytic tests cleaning step presence water vapour followed purging gas phase second step addition allow one discern carbon containing gaseous products originated carbon impurities produced presence second step presence copper grafted photocatalyst surface favours evolution respect fully reduced elsevier rights reserved
photocatalytic hydrogen generation considered attractive due combination solar energy conversion storage currently used systems either based homogeneous heterogeneous materials possess light harvesting catalytic subunit subject review brief summary homogeneous proton reduction systems using sacrificial agents special emphasis non noble metal systems applying convenient iron sources iridium photosensitizers proven high quantum yields employed well copper photosensitizers cases addition presence phosphine led transformation iron precursor subsequently increased activities reaction pathways investigated photoluminescence electron paramagnetic resonance epr raman ftir mass spectroscopy well time dependent dft calculations future knowledge set basis design photo electro chemical devices tailored electron transfer cascades without need sacrificial agents
phthalates widely used plasticizers household products several studies reported association phthalate exposure increased risk allergies present study estimated phthalate exposure children aged years assessed potential correlations allergies house dust samples collected floors multi surface objects floor urine samples collected first morning void day daily phthalate intake didust estimated using house dust urinary metabolite concentrations exposure ethylhexyl phthalate dehp floor dust associated parental reported rhino conjunctivitis stratification gender trend found occur boys furthermore urinary mono isobutyl phthalate inversely associated parental reported wheeze boys didust benzyl butyl phthalate bbzp dehp significantly correlated bbzp dehp respectively correlations stronger floor multi surface dust results suggest among japanese children house dust low surfaces living room floors might play meaningful role indoor environmental exposure pathway bbzp dehp elsevier ltd rights reserved
phychography important technique quantitative phase imaging research domain employs illuminating probes scan specimen overlapped requirement reconstruction conducted using ptychographic iterative engine contradiction imaging efficiency quality become bottleneck wide applications paper start fundamental principle iterative algorithms ptychographical imaging propose two parallel schemes based cpu gpu besides influences specimen size number blocks illuminating beams speedup two schemes investigated via simulation experiment result shows complex amplitude specimen correctly reconstructed meanwhile speed significantly improved reduces time consumed one order magnitude improvement solves contradiction expect achieve quasi real time imaging experimental data also indicate optimal partition parallel speedup related size specimen bigger size corresponding obvious acceleration specimen different partitions speed different extents closely related experimental hardware however number illuminating beams significant effect speedup
physical activity help reduce cardiovascular disease premature mortality people psychosis however paucity representative data people psychosis especially low middle income countries lmics moreover data subclinical psychosis absent study explored whether complying recommendations minutes moderate vigorous per week related psychotic symptoms without psychosis diagnosis subclinical psychosis clinical psychosis psychosis diagnosis total participants aged years lmics recruited via world health survey subdivided psychosis diagnosis psychotic symptoms past months controls subclinical psychosis psychosis diagnosis people psychosis diagnosis significantly higher odds low overall sample among males females difference found among subclinical psychosis controls mediation analyses demonstrated mobility difficulties explained largest amount low among males followed self care difficulties depression cognition pain discomfort interpersonal activities sleep energy vision results largest dataset psychosis first lmics found psychosis diagnosis especially among males subclinical psychosis associated physical inactivity population level interventions seeking increase among people psychosis may help improve health outcomes
physical activity sports participation promoted counteract increased prevalence overweight obesity children young adults high body mass index physical activity level associated increased risk sports injuries objective determine relationship sports injuries overweight sports participants years taking physical activity account data obtained injuries physical activity netherlands survey analyses based representative sample sports participants years univariate multiple logistic regression analyses applied investigate association sports injury weight status sports participants overweight compared normal weight sports participants odds sustaining sports injury confidence interval overweight sports participants odds underweight sports participants evidence overweight sports participants years increased injury risk compared normal weight sports participants even level physical activity taken account additional research recommended regarding overweight people start participate physically active lifestyle
physical aggression toddler years common developmentally normal however longitudinal research shows frequent highly stable associated long term negative outcomes significant research demonstrated efficacy parenting interventions reducing externalizing behavior children yet typical length may overburden families leading low participation rates high attrition rates increase reach parenting interventions impact prevalence externalizing behavior problems brief interventions needed rct compared standard session group triple brief session discussion group waitlist control reducing toddler dysfunctional parenting related aspects parent functioning sixty nine self referred families toddlers randomized respective conditions post assessment families standard intervention significantly lower levels observed child aversive behavior mother reports dysfunctional parenting higher levels mother partner rated behavioral self efficacy waitlist control families standard intervention also significantly lower levels mother rated dysfunctional parenting brief intervention brief intervention significantly lower levels mother rated dysfunctional parenting waitlist significant group differences post assessment measures parental negative affect satisfaction partner relationship month follow families brief standard intervention differ significantly measure implications findings delivery brief parenting interventions discussed aggr behav wiley periodicals inc
physical education teacher education pete students considerable risk non contact sports injuries lower extremities multifactorial injury prevention interventions including exercises successful sports populations study ever performed pete students study investigated efficacy multifactorial injury prevention intervention injury incidence reduction pete students pete students intervention group control group registered sports injuries prospectively intervention lasted one academic year consisted injury awareness programme preventive strategies implemented pete sports lecturers differences injury incidence intervention control group tested poisson regression wald tests trend towards significantly lower incidence rate intervention group compared control group students intervention group significantly less acute first time extracurricular injuries largest reduction observed injuries unsupervised practice sessions multifactorial injury prevention intervention embedded regular pete programme promising feasible strategy prevent injuries pete students research needed investigate whether results may generalised pete programmes
physical emotional sexual child abuse major problems south africa study investigates whether children know post abuse services disclose seek services outcomes help seeking behaviour examines factors associated request receipt services confidential self report questionnaires completed adolescents aged south africa prevalence frequent weekly physical abuse frequent emotional abuse lifetime contact sexual abuse could name one suitable confidante formal service abuse disclosure abuse victims disclosed received help common confidantes caregivers teachers abuse victims receive help due non disclosure inactivity services received help formal health social services community vigilante action emotional abuse sexual abuse female gender associated higher odds help seeking children south africa showed high knowledge available services access receipt formal services among abused children low notably fewer children received help formal services community vigilante action urgent action needed improve service access child abuse victims
physiological modeling retina plays vital role development high performance image processing methods produce better visual perception people normal vision ability discern different colors situation different case people color blindness aim work develop human visual system model detecting level perception people red green blue deficiency considering properties like luminance spatial temporal frequencies simulation results show photoreceptor outer plexiform inner plexiform layers energy intensity level red green blue component normal person proved significantly higher dichromats proposed method explains appropriate results red blue color blindness people could perceive red blue color completely
phytochelatins pcn gamma glu cys gly glutathione gsh precursor thiol rich peptides play important role heavy metal detoxification plants microorganisms complex formation gsh pcn investigated microcalorimetry absorption spectrophotometry jump kinetics complex formation exothermic induces ligand metal charge transfer bands absorption spectral range implies formation coordination bond metal thiol groups phytochelatins absorption spectra microcalorimetry experiments allow determination affinity constants stoichiometry complexes show three pcn interact form complexes similar affinity constants log similar log similar affinities independent number thiols moreover lower determined complex formation hand complexes detected furthermore complex stable affinity constant log similar kinetic studies indicate complex formation gsh occurs range direct rate constant obs reverse rate constant obs thus encapsulated silica matrix pcn good candidates heavy metal detection elsevier ireland ltd rights reserved
piks potential therapeutic targets immune inflammatory diseases studies aimed investigate safety tolerability profile seletalisib selective inhibitor pik delta humans phase randomised double blind placebo controlled single centre studies nct nct evaluated single multiple oral doses seletalisib bid healthy adults subjects mild moderate psoriasis study pharmacodynamic effects markers inflammation assessed via changes vivo basophil degranulation histological assessment psoriatic skin biopsies seletalisib well tolerated doses study study days safety concerns dose limiting toxicities identified study incidence gastrointestinal related aes dose related higher incidences rash aes associated higher dose seletalisib study rash aes seletalisib treated subjects versus placebo treated subject mean seletalisib plasma concentration time profiles increased increasing doses single multiple dosing major deviations dose proportionality unexpected accumulation loss exposure multiple dosing time independent pharmacokinetic profile apparent values supportive daily dosing geometric mean study study clinically significant food effect observed study pharmacodynamic findings demonstrated vivo inhibition basophil degranulation improvements histological assessment skin biopsies markers psoriatic biology preliminary evidence target engagement psoriatic skin tissue seletalisib safety tolerability pharmacokinetic pharmacodynamic profiles support continued clinical development immune inflammatory diseases
pid controller structure regarded standard control engineering community supported vast range automation hardware therefore pid controllers widely used industrial practice however problem tuning controller parameters tackled control engineer often dealt optimal way resulting poor control performance even compromised safety paper proposes framework involves using interval model describing uncertain variable dynamics process framework employs particle swarm optimization algorithm obtaining best performing pid controller regard several possible criteria time taking account complementary sensitivity function constraints ensure robustness within bounds uncertain parameters intervals hence presented approach enables simple computationally tractable efficient constrained optimization solution tuning parameters controller considering eventual gain pole zero time delay uncertainties defined using interval model controlled process results provide good control performance assuring stability within prescribed uncertainty constraints furthermore controller performance adequate relative system perturbations considered proposed paper proposed approach tested various examples results suggest useful framework obtaining adequate controller parameters ensure robust stability favorable control performance closed loop even considerable process uncertainties expected elsevier rights reserved
piezoresistive behavior ketjenblack reinforced deproteinized natural rubber dpnr nanocomposite developed two roll mill studied compressive pressure mpa dpnr exhibited monotonic piezoresistivity highest electrical resistance change remarkable reversibility minimal hysteresis furthermore good sensitivity mpa mpa high test retest reliability intraclass correlation efficient icc mpa three repetitions conducted interval excellent repeatability standard deviation swing mpa cyclic compression achieved homogeneous dispersion high aspect ratio higher chemical linkage due double crosslinking agents dpnr may responsible enhanced piezoresistivity practical application dpnr interfaced microcontroller bridge rectifier via custom built simulink successfully monitored finger pressure real time bone movement human wiley periodicals inc
piper nigrum fruits prized spice also highly valued therapeutic agent heals many ailments including asthma cold respiratory problems herein investigated structural features vivo antitussive activity three fractions isolated piper nigrum fruits water extract upon fractionation etoh yielded two fractions soluble fraction esf precipitated epf one existence pectic polysaccharide arabinogalactan type side chains kda epf piperine esf revealed moreover oligosaccharides providing fine structural details side chains generated epf characterized parental water extract contained pectic polysaccharide piperine oral administration body weight guinea pigs showed antitussive activity comparable codeine phosphate body weight etoh precipitated fraction epf containing pectic polysaccharide showed comparatively higher antitussive activity etoh soluble fraction esf contained piperine potencies lower parental water extract significantly specific airway smooth muscle reactivity three fractions remained unchanged finally pectic polysaccharide piperine combination parental extract synergistically enhances antitussive effect guinea pigs elsevier rights reserved
pityriasis rubra pilaris prp plaque psoriasis two distinctive erythemato squamous skin diseases often differentiated similar dermatoses dermoscopy proven aid clinical diagnosis several inflammatory disorders minimizing need skin biopsy aim determine dermoscopic patterns prp compared assess significance certain dermoscopic criteria diagnosis prp case control study included patients biopsy proven prp patients biopsy proven plaque psoriasis recently developed lesion patient examined non contact dermoscopy whitish keratotic plugs linear vessels yellowish background significant dermoscopic features prp compared white diffuse scales dotted vessels light red background conclusion prp reveal specific distinguishing dermoscopic patterns may assist clinical diagnosis may also useful differential diagnosis resembling dermatoses
planar auxetic structures potential impact wide range applications deployable morphing structures space filling composite medical treatments ability fabricate auxetics smart materials greatly enhances facility building controllable actuation deployment smart auxetic device compressed fixed storage state deployment required device appropriately stimulated stored elastic energy released resulting marked structural expansion instead using conventional external actuator drive deployment material made undergo phase transition one stimulus heat initiates mechanical response show smart material auxetics realized using thermally responsive shape memory polymer composites show shape memory polymer auxetic hexachiral structure tailored provide tunable stiffness response fully deployed state varying angle inter hub connections yet still able undergo thermally stimulated deployment
planar nanoscopic contacts observed undergo early electrical breakdown authors show cause high field emission capable triggering electromigration phenomenon well described empirical current voltage law well different usually found nonflat field emitters attributed particular geometry contacts although mathematical form law always intensity breakdown current changes sample sample ranging several orders magnitude explained nanoscopic roughness emitting surfaces also show occurrence breakdown may dependent polarity applied voltage
plasma kallikrein serine protease trypsin clan plays critical roles many physiological pathological pathways regulating abnormal activity successfully used clinical therapy hereditary angioedema study serine protease domain murine plasma kallikrein mpk expressed pichia pastoris system recombinant protein glycosylated active enzyme purification cation exchange size exclusion chromatography crystallized precipitant condition peg tris hcl nacl crystal structure mpk determined angstrom first published crystal structure mpk showing distinctive features pockets compared human analogue human plasma kallikrein hpk addition mpk show unique structural features non conservative loops compared serine proteases results provide insights design potent selective inhibitors
plasma stability one obstacles path successful operation fusion devices numerical control oriented codes case widely accepted rzip may used within tokamak simulations novelty article relies hierarchical development dynamic control loop based current profile model predictive control mpc algorithm within multiloop structure mpc developed step improve proportional integral derivative pid global scheme inner control loop composed pid based controller acts multiple input multiple output mimo system resulting rzip plasma model tokamak configuration variable tcv coefficients pid controller initially tuned using eigenmode reduction passive structure model control action corresponding state interest optimized outer mpc loop sake comparison traditionally used pid global controller well multiloop enhanced mpc applied tcv shot results show proposed control algorithm presents superior performance conventional pid algorithm terms convergence furthermore enhanced mpc algorithm contributes extend discharge length overcome limited power availability restrictions hinder performance advanced tokamaks
plenty design parameters used electric machine design process generally design parameters looked existing curves drawn magnetic field graphing method analytical method affected different draftsmen proficiency precision parameter curves drawn magnetic field graphing method uncertainty using analytical drawing method draw design parameter curves usually simplifies analytical model electric machine improve calculating efficiency simplified analysis model results less accuracy problems order improve accuracy electric machines design calculation finite element method fem used analyze electromagnetic field calculate design parameters based complete electric machine model paper analytic objects series evaporative cooled generator motor design parameter curves drawn paper accurate existing curves electric machine similar size structure
plerixafor although costly added mobilizing chemotherapy csf overcome poor stem cell mobilization demonstrate safely administered mostly single dose preemptive rescue settings leading apheresis yields cells body weight respectively note patients showed substantial benefit increased peripheral blood cells prior apheresis fold increased cells collected per single apheresis respectively cells plerixafor application respectively thus careful patient selection latter group advised best knowledge first report demonstrating favorable apheresis results obtained using cost efficient single fixed dose plerixafor schedule
plumbagin hydroxy methyl naphthoquinone major active constituent plumbago indica shown effective wide range infectious microbes study plumbagin evaluated vitro antifungal combinatory effect amphotericin candida albicans albicans clinical isolates anti hepatitis virus hcv activity antifungal activity determined broth microdilution method combinatory effect evaluated checkerboard assay according sigma fic indices cytotoxicity determined mtt assay anti hcv activity determined infected huh cells using quantitative real time reverse transcription pcr cytotoxicity evaluated mtt assay plumbagin exerted inhibitory effect albicans strains minimum inhibitory concentration values ranging additive effect plumbagin combined amphotericin concentrations respectively obtained five seven strains tested sigma fic ranging addition plumbagin found used safely topical application combined amphotericin concentrations corresponding additive effect plumbagin exerted anti hcv activity compared telaprevir values respectively selectivity indices respectively results present plumbagin potential therapeutic agent treatment albicans hcv infections copyright john wiley sons ltd
plunging water jets used oxygenation purposes due inherent advantages simplicity energy efficiency low operational cost specifically provide efficient gas liquid interfacial area dissolving oxygen water oxygen transfer plunging jets stagnant water received considerable attention however oxygenation capacity plunging water jets discharging turbulent cross flow received limited attention flow characteristics volumetric oxygen transfer coefficient standard oxygen transfer efficiency evaluated considering water jet cross flow velocity ratio jet fall height cross flow depth jet impact angle two equations proposed estimating oxygen transfer rate single plunging jet turbulent cross flow moreover dynamic behavior resulting two phase air water flow investigated aid flow visualization american society civil engineers
major public health concern severe diseases attributed exposure ever comprehensive understanding gene microrna expression patterns induced missing objective study evaluate toxicity via genome wide transcriptional analysis model teleost fish zebrafish danio rerio gene ontology analysis revealed impact gene functional categories induced included oxidation reduction process transport response xenobiotic stimulus response chemical stimulus metabolic process pathway signal net analysis showed critical pathway involved response exposure metabolism xenobiotics cytochrome results verification experiments also demonstrated key genes degree higher induced related metabolism xenobiotics cytochrome including cypa mgst gstp gsto gsto cypa ehx gsta aldhb differential expression micrornas corresponding human genome revealed could regulate let mir mir mir regulate ulet mir mir mir suggested multiple means induced toxicity living organisms suppression adaptive immune responses autophagy deregulation metabolism impaired vasorelaxation progression cancers well hypertension atherosclerosis myocardial infarction elsevier rights reserved
pmsg wind turbine system configured three level neutral point clamped npc back back power converter direct drive train good properties nice solution high power wind energy applications direct model predictive control emerged viable alternative power electronics electrical drives work presents direct model predictive current control dmpcc solution grid generator side control grid connected npc back back power converters pmsg wind turbine systems presented dmpcc realized alpha beta frame evaluated experimental results fully fpga based platform experimental results confirm effectiveness better steady state control performances comparison conventional switching table based dtc dpc technique
pneumonia refers lung inflammation caused different pathogens factors common pediatric disease occurring infants young children closely related anatomical physiological characteristics infants young children frequent winter spring sudden changes temperature pneumonia serious disease poses threat children health morbidity mortality rank first accounting pediatric inpatients due juvenile age severe illness rapid changes children often suffer acute heart failure respiratory failure even toxic encephalopathy time concurrence different stages process emergency treatment tends relapse directly places lives children risk severe pneumonia constitutes one main causes infant mortality process nursing children severe pneumonia intensive care provided including condition assessment diagnosis close observation disease keeping airway unblocked rational oxygen therapy prevention treatment respiratory circulatory failure support vital organs complications health education inflammatory response proactively controlled prevent suffocation reduce mortality summary positive effective nursing promote rehabilitation children patients reinforced adequate communication parents caretakers
point cloud data important source geoinformation modern day data acquisition processing techniques airborne laser scanning multi beam echosounding generate billions points simply area square kilometers size point clouds exceeding billion mark even small area need efficient storage management point clouds sometimes associated attributes constraints well storing billions points currently possible confirmed initial implementations oracle spatial sdo postgresql point cloud extension able analyse extract useful information point clouds need points require surface defined points space different ways represent surfaces gis including grids tins boundary representations etc study investigate database solutions storage management massive tins classical face edge based compact star based data structures discussed length reference structure advantages limitations handling massive triangulations compared current solution postgis simple feature main test dataset tin generated third national elevation model netherlands ahn point density points postgresql postgis dbms used storing generated tin data structures tested generated tin models account geometry topology storage indexing loading time database study useful identifying limitations existing data structures storing massive tins required optimise structures managing massive triangulations database
point compression essential technique save bandwidth memory deploying elliptic curve based security solutions wireless communication systems contribution provide new linear algebra based compression algorithms multiple points elliptic curves compression algorithms make use constant number field multiplications one inversion quadratic higher degree polynomial root finding particular extend results khabbazian ieee trans comput four resp five points elliptic curves generically storing five resp six field elements provide asymptotic generalization number points curve generically storing values
political economical changes past years significant influence almost countries economical life high developed countries react changes marketing using high performance working methods raising investments researching fields world competitive manufactures attention last years competitive environment friendly products development adopted concept integrated manufacturing strategy achieving shorter time market reduced development costs high quality products manufacturing engineering department cluj napoca started introduce concept university romanian industry paper presents steps achievements field competitive product development
poly isopropylacrylamide nipaam well known smart material good thermal sensitivity favorable biocompatibility series new smart hydrogels nipaam copolymerized iam itaconamic acid amino methylene oxobutanoic acid synthesized radical solution polymerization work poly nipaam iam respond changes temperature well value characteristic due fact iam contains hydrophilic acrylic acid moiety also acrylamide moiety thermal sensitive experimental results show lower critical solution temperature lcst copolymer increases molar fraction iam increases moreover based current experimental data poly nipaam iam aqueous solution study exhibits phase transition temperature degrees close human body temperature buffer solution possibly useful drug delivery wiley periodicals inc
polyaniline pani adopted modify sns develop novel efficient visible light driven photocatalyst sns pani composite synthesized via first mixing sns pani dimethylformamide solution subsequent evaporation dimethylformamide characterization raman fourier transform infrared spectroscopy demonstrated production sns pani composite vis diffuse reflectance absorbance spectra showed coupling pani enhanced visible light absorbing capability sns photoluminescence electrochemical impedance spectra showed sns pani composite efficient separation transfer photogenerated charges sns photocatalytic tests showed sns pani composite exhibited notably higher photocatalytic activity sns reduction aqueous visible light lambda irradiation rate photocatalytic reduction sns pani composite nearly times sns possible reasons underlying enhanced photocatalytic activity sns pani composite also proposed elsevier rights reserved
polycythemia vera chronic myeloproliferative disease often complicated thromboembolism however aortic stenosis could manifestation cardiovascular complications possibly shear stress atherosclerosis report rare case rapidly progressed patient
polypyrrole based actuators interest due biocompatibility low operation voltage relatively high strain force modeling simulation important predict behaviour actuator develop accurate model need know electro chemo mechanical specifications polypyrrole paper non linear time variant model polypyrrole film derived proposed using combination transmission line model state space representation model incorporates potential dependent ionic conductivity function ionic conductivity polypyrrole local charge proposed implemented non linear model matching measured simulated electrical response suggests ionic conductivity polypyrrole decreases significantly negative potential silver silver chloride leads reduced current cyclic voltammetry tests next stage relate distributed charging polymer actuation via strain charge ratio work also needed identify ionic electronic conductivities well capacitance function oxidation state fully predictive model created
polyurethane modified epoxy resin prepared polyurethane prepolymer pup effects pup content epoxy resin type mechanical thermal properties materials discussed results indicate tensile strength impact strength material increase maximum successively decrease increasing addition pup mass fraction pup tensile strength impact strength materials best significant differences mechanical thermal properties material different epoxy best results cured epoxy tde
pooled data seven randomized placebo controlled trials analysed evaluate relationships baseline body mass index bmi gender age efficacy tolerability solifenacin daily patients overactive bladder oab changes efficacy variables baseline weeks compared patients symptoms baseline solifenacin treated placebo treated groups normalization rates calculated eight micturitions one episode nocturia per night zero values variables treatment emergent adverse events teaes recorded baseline incidence incontinence urgency incontinence increased increasing bmi age relatively women men incontinent baseline incidence urgency similar genders among age groups tended increase increasing bmi baseline frequencies micturition nocturia similar bmi categories genders age groups results meta analysis integrated database data trials investigating solifenacin showed solifenacin efficacious placebo oab symptoms across bmi age categories genders normalization rates micturition frequency incontinence urgency greater patients receiving solifenacin receiving placebo across categories overall incidence teaes higher patients receiving solifenacin receiving placebo solifenacin generally well tolerated groups overall frequency teaes solifenacin placebo slightly higher women men older younger patients commonly reported teaes dry mouth constipation regardless bmi gender age patients oab considered candidates solifenacin treatment
poor adherence preventive behaviors lead recurrence diseases despite current interventions assist patients adherence preventive routines minimal improvement behaviors however thailand research studies done describe adherence preventive behaviors study particular sought explore characteristic adherence regarding preventive behaviors thais prehypertension descriptive qualitative method using depth interviews nine participants self identified successful adherence preventive behaviors used participants recruited three selected primary health care units located three provinces southern thailand data analyzed using content analysis three main themes adherence preventive behaviors identified commitment active participation sub themes intentional action expected success self discipline persistence practicing preventive behaviors sub themes repeated action regular pattern maintenance desired preventive behaviors sub themes long term behavior changes sensations well results supported adherence preventive behaviors multidimensional behavior involving exercise dietary control stress management finding may influence nurses health care providers design intervention programs congruent social cultural contexts enhancing adherence preventive behaviors
population growth urbanisation climate change represent significant pressures urban water resources requiring water managers consider wider array management options account economic social environmental factors dynamic urban water simulation model duwsim developed study links urban water balance concepts land use dynamics model moland climate model lars providing platform long term planning urban water supply water demand analysing effects urbanisation scenarios climatic changes urban water cycle based potential urbanisation scenarios effects city water cycle duwsim provides functionality assessing feasibility centralised decentralised water supply water demand management options based forecasted water demand stormwater wastewater generation whole life cost energy potential water recycling duwsim tested using data dublin capital ireland shown model able satisfactorily predict water demand stormwater runoff elsevier ltd rights reserved
positive energy residential buildings houses generate energy renewable sources consume maintaining appropriate thermal comfort levels however design construction operation present several critical challenges particular considerable load reductions always compatible increased level comfort expected modern houses tropical climates meanwhile amenable implementation positive energy houses two reasons firstly negligible heating generally required compared colder climates heating energy requirements considerable renewable energy resources usually abundant tropical climates paper investigates feasibility positive energy residential buildings tropical island mauritius baseline model representing typical mauritian house designed using designbuilder software energy efficiency model optimised investigating whole range passive building design strategies many adapted vernacular architecture results reveal application passive strategies shading insulation natural ventilation precluded need artificial cooling ventilation positive energy house resulting electricity consumption house decreases kwh year photovoltaic system provides cost effective solution exceed annual electricity requirements house
positive intergroup contact socially economically advantaged national majorities shown reduce ethnic identification among minorities thereby undermining ethnic minority activism finding implies ethnic identity relevant social identity driving ethnic minorities struggle equality argue study sedating effect positive intergroup contact minorities nuanced existence multiple sometimes interplaying social identities foster reinterpretation meaning ethnic activism study therefore examines interplay ethnic national identities shapes sedating effect contact minority activism expect national identification buffer sedated activism resulting reduced ethnic identification mediation intergroup contact reduced ethnic activism weakened ethnic identification expected moderated national identification survey data bulgaria investigated support ethnic activism among bulgarian roma function contact national majority well degree ethnic national identification predicted moderated mediation revealed negative indirect relationship contact activism decreased ethnic identification occurred among roma low national identification whereas sedating effect occurred among roma identifying strongly members bulgarian nation discuss meaning national identification roma minority experience harsh discrimination countries historically settled well convergence findings work dual identification highlight role interacting social identities mobilizing resources activism importance adopting critical view ethnic discourse studying activism traditional immigrant minorities
positive temperature coefficient ptc material kind thermo sensitive material using ptc resistors replace ordinary resistive materials heating elements may become new means precise temperature control electronic devices paper novel ptc material curie temperature degrees prepared new thermal control method combining ptc material proportional integ ral derivative pid control algorithm proposed experimental system mathematical model pid temperature control using ptc material established based pid temperature control performance ptc material investigated comparison ordinary resistance heater experimentally theoretically results show using ptc material pid temperature control effectively reduce overshoot parameters pid controller within certain ranges temperature control effects ptc material superior ordinary heater temperature overshoot reduced temperature control accuracy increased furthermore preparing ptc material larger resistance temperature coefficient may likely contribute improve pid temperature control effect research results specify possible directions pid temperature control using ptc materials order achieve precise thermal control electronic devices elsevier ltd rights reserved
positivity heralded individual benefits however positivity dynamically unfolds within temporal flow team interactions remains unclear important oversight positivity key team problem solving performance study examine team micro processes affect likelihood positivity occurring within dynamic team interactions build expand previous work individual positivity integrate theory temporal team processes interaction rituals team problem solving analyze utterances meetings problem solving teams two organizations first find observed overall frequency positivity behavior team positively related managerial ratings team performance second using statistical discourse analysis show solution focused behavior previous positivity within team interaction process increase likelihood subsequent positivity expressions whereas positivity less likely problem focused behavior dynamic speaker switches moderate effects interaction instances involving speakers increase facilitating effects solutions earlier positivity subsequent positivity within team interactions discuss theoretical managerial implications micro level team positivity performance benefits
positron annihilation lifetime spectroscopy applied study point defects formed upon diffusion semi insulating gaas diffusion performed annealing samples degrees different times different vapor pressures deep shallow positron traps observed lifetime spectroscopy acceptors assumed act shallow traps complex containing vacancy atoms suggested deep positron traps observation vacancy complexes elucidated studying influence vapor pressure applying mass action law thermodynamics point defects acta materialia inc published elsevier ltd rights reserved
possible associations television viewing video game playing children aggression become public health concerns systematic review studies examined associations focussing children young people behavioural emotional difficulties thought susceptible computer assisted searches health social science databases gateways publications relevant organizations grey literature scanned bibliographies hand searched key journals corresponded authors critically appraised studies total studies three experiments children behavioural emotional difficulties found increased aggression watching aggressive opposed low aggressive content television programmes one found opposite two clear effect one found children likely controls imitate aggressive television characters one case control study one survey found children young people behavioural emotional difficulties watched television controls another two studies found children young people behavioural emotional difficulties viewed hours aggressive television programmes controls one study video game use found young people behavioural emotional difficulties viewed minutes violence played longer controls qualitative study children behavioural emotional difficulties parents associate watching television aggression studies significant methodological flaws none based power calculations systematic review found insufficient contradictory methodologically flawed evidence association television viewing video game playing aggression children young people behavioural emotional difficulties public health advice evidence based good quality research needed
postgastrectomy syndromes result altered form function stomach gastrectomy disrupts reservoir capacity mechanical digestion gastric emptying early recognition symptoms prompt evaluation treatment essential many syndromes resolve minimal intervention dietary modifications operation common often warranted afferent efferent loop syndromes bile reflux gastritis preoperative nutritional assessment treatment common vitamin mineral deficiencies gastrectomy reduce incidence chronic complications integrated team approach risk assessment patient education postoperative management critical optimal care patients gastric cancer
postoperative blindness primarily involves reception conductance parts visual pathway due ischemia following cessation blood supply example retinal vascular occlusion although rare cause cortical blindness results ischemia infarction visual cortex poor outcome due mostly nonreversible nature ischemic optic neuropathy common cause following cardiac surgeries following cardiac surgeries involving cardiopulmonary bypass rarely reported articles reported partial complete reversal report incidence transient year old child operated double chambered right ventricle ventricular septal defect
posttraumatic stress disorder ptsd strongly associated suicide department veterans affairs department defense clinical practice guidelines ptsd dod cpg endorse cognitive therapy variants empirically supported ptsd treatments however lack understanding whether treatments generalizable patients suicidal ideation behaviors randomized controlled trials rcts cited dod cpgs systematically reviewed methodology suicide related content adverse event reporting thirty eight rcts reviewed twenty three reported suicide related exclusion criteria made mention suicide related inclusion exclusion criteria thirty six rcts included depression assessments containing suicide related items suicide relevant data reported two rcts outlined suicide risk monitoring procedures suicidal ptsd participants underrepresented ptsd rcts suicide risk assessment procedures inconsistently reported standardized reporting rct methods pertaining suicide risk determine generalizability safety empirically supported ptsd treatments clinical population needed
potential human health risk waterborne diseases arising unsatisfactory performance site wastewater treatment systems driven landscape factors topography soil characteristics depth water table drainage characteristics presence surface water bodies factors present random variables spatially distributed across region methodological framework presented applied model evaluate influence various factors waterborne disease potential framework informed spatial data expert knowledge prediction unsampled sites interpolation methods used derive spatially smoothed surface disease potential takes account uncertainty due spatial variation pre determined level significance surface constructed accounting influence multiple variables appear contribute disease potential framework developed work strengthens understanding characteristics disease potential provides predictions potential across region study outcomes presented constitutes innovative approach environmental monitoring management face data paucity elsevier rights reserved
power line communications plc used information exchange lines installed delivering electrical power home plc technology delivers telecom services every corner household already existing electrical wiring home plc channel offers multiple signal feed ports usually comprises three wires phase neutral protective earth measurements results presented paper shows impact load impedances connected electrical network insertion gain capacity multiple input multiple output mimo plc channel
practice effects improvements cognitive tests result repeated exposure testing material however variability exists literature whether patients amnestic mild cognitive impairment mci display practice effects may partially due methods used calculate changes repeated tests purpose current study examine multiple methods assessing short term practice effects older adults mci cognitive battery included tests memory hopkins verbal learning test revised brief visuospatial memory test revised processing speed symbol digit modalities test trail making test parts administered twice across one week dependent tests showed statistically significant improvement memory scores processing speed scores despite sample showed clinically meaningful improvement cognitive scores using three different reliable change indices regression based change scores identify relatively large groups participants showed smaller expected practice effects may indicate method sensitive identifying individuals may portend declining trajectory practice effects remain complex construct worthy continued investigation diverse clinical conditions
precision global health approach similar precision medicine facilitates innovation technology better targeting public health interventions global scale purpose maximising effectiveness relevance illustrative examples include use remote sensing data fight vector borne diseases large databases genomic sequences foodborne pathogens helping identify origins outbreaks social networks internet search engines tracking communicable diseases cell phone data humanitarian actions drones deliver healthcare services remote secluded areas open science data sharing platforms proposed fostering international research programmes fair ethical respectful conditions innovative education massive open online courses serious games promote wider access training public health improving health literacy world moving towards learning healthcare systems professionals equipped data collection decision support devices share information complemented external sources analysed real time using machine learning techniques allow early detection anomalies eventually guide appropriate public health interventions article shows information driven approaches enabled digital technologies help improving global health greater equity
preclinical alzheimer disease relatively recent concept describing entity characterized presence pathophysiological biomarker signature characteristic absence specific clinical symptoms rising interest scientific community define early target population mainly failures recent clinical trials despite evidence biological effects brain amyloidosis compounds conceptual framework recently proposed preclinical phase however data exist silent stage performed systematic review investigate concept defined across studies review highlights substantial heterogeneity concerning three main determinants preclinical normal cognition cognitive decline pathophysiological signature emphasize need harmonized nomenclature preclinical concept standardized population based case control studies using unified operationalized criteria alzheimer association published elsevier inc rights reserved
predicting building damage due subsidence phenomena great challenge field risk management moreover process disaster risk reduction proposed damage assessment integrates measurements obtained satellite synthetic aperture radar sar observations semiempirical model schematizes buildings equivalent laminated beams importance parameters involved semiempirical method evaluated understand applicability model different urban contexts sar monitoring structural modeling connected investigate densely urban area southern part city rome information obtained two fields allowed generation risk maps
predicting engineering properties materials prior synthesis enables integration design overall engineering process context present article discusses foundation requirements software platforms predicting materials properties modeling simulation electronic atomistic mesoscopic levels addressing functionality verification validation robustness ease use interoperability support related criteria based requirements assessment made current state revealing two critical points large scale industrial deployment atomistic modeling namely ability describe multicomponent systems compute structural functional properties sufficient accuracy expertise needed translating complex engineering problems viable modeling strategies deriving results direct value engineering process progress challenges undeniable illustrated examples structural functional materials including metal alloys polymers battery materials fluids perspectives evolution modeling software platforms show need fundamental research improve predictive power models well coordination support actions accelerate industrial deployment
predicting performance application running parallel computing platforms increasingly becoming important due long development time application high resource management cost parallel computing platforms however predicting overall performance complex must take account parallel calculation time communication time difficulty accurate performance modeling compounded myriad design choices along multiple dimensions namely process level parallelism distribution cores multiprocessor platforms iii application related parameters characteristics datasets research proposes fast accurate performance prediction approach predict calculation communication time application running distributed computing platform major contribution prediction approach provide accurate prediction execution times new datasets much larger sizes training datasets approach consists two models probabilistic self learning model predict calculation time simulation queuing model predict network communication time combination two models provides data analysts useful insight optimal configuration parallel resources number processes number cores application parameters setting
predicting grasping function reach grasp motions essential controlling prosthetic hand robotic assistive device early accurate prediction increases usability comfort prosthetic device work proposes electromyographic based learning approach decodes grasping intention early stage reach grasp motion final grasp hand pre shape takes place superficial electrodes cyberglove used record arm muscle activity finger joints reach grasp motions results showed accuracy detection final grasp motion onset paper also examines effect different objects distances different motion speeds detection time accuracy classifier use learning approach control degrees freedom robotic hand confirmed usability approach real time control robotic devices elsevier rights reserved
predicting protein structure sequence remains major open problem protein biochemistry one component predicting complete structures prediction inter residue contact patterns contact maps discuss protein contact map prediction machine learning describe novel method contact map prediction uses evolution logic circuits logic circuits operate feature data output whether two amino acids protein contact show method feasible addition evolution allows logic circuits trained dataset unbiased manner used contact map prediction selection relevant features dataset
predictive control attracted much attention widely used power electronics electric drives however developments applications field renewable energy systems still investigation paper principles predictive control studied focus model predictive control mpc vector sequence based predictive control vpc based techniques two control strategies flexible power supply developed implemented promising renewable energy systems namely solar photovoltaic systems wind generators respectively experimental results based laboratory prototype show active reactive powers supplied wind generator controlled flexibly excellent steady state transient performance penetration level renewable energy sources electricity network continues rise predictive control tends attractive powerful technique power electronics converters renewable energy systems
pre exposure prophylaxis hiv prep recommended people inject drugs pwid despite central role disease prevention willingness prescribe prep pwid among primary care physicians pcps largely understudied conducted online survey april may members society academic general internists regarding prep among respondents pcps reported high willingness prescribe prep pwid pcps likely report high willingness prescribe prep hiv risk groups pair comparisons compared pcps delivering care hiv infected clinic patients pcps delivering care fewer hiv infected patients likely report low willingness prescribe prep pwid odds ratio pcp practice characteristics otherwise associated low willingness prescribe prep pwid interventions improve pcps willingness prescribe prep pwid needed
preliminary findings suggest attention deficit hyperactivity disorder adhd may associated disordered eating behaviour whether sufficient evidence suggest association adhd specific types disordered eating behaviour unclear furthermore uncertain whether specific features associated adhd differentially associated disordered eating behaviour systematic review seventy five studies conducted evaluate potential association adhd symptomatology disordered eating behaviour provide estimate strength evidence association overall moderate strength evidence exists positive association adhd disordered eating specific types disordered eating behaviour particular overeating behaviour consistent evidence impulsivity symptoms adhd positively associated overeating bulimia nervosa limited evidence association hyperactivity symptoms restrictive eating males females research required assess potential direction relationship adhd disordered eating underlying mechanisms role specific adhd symptoms development maintenance disordered eating behaviour propose framework could used guide design future studies authors published elsevier ltd
premature infants shorter prenatal development period prone many serious medical problems neonatal period may impact development oral tissues manifested enamel hypoplasia palatal distortion malocclusion delay tooth eruption maturation kangaroo mother care kmc standardized protocol based care system premature infants based skin skin contact infant mother kangaroo mother care demonstrated greatly improve nurturing premature infants comparatively reduce risk factors oral defects hypothesize kmc also facilitates oral growth development premature infants
premature ovarian failure pof kind gynecological disease causes amenorrhea infertility menopause urogenital symptoms currently hormone replacement therapy hrt popular choice women pof get rid menopausal syndrome however popularization chinese herbs made chinese medicine shine new lights physicians able treat pof meno herbs integrated therapy hrt indications contraindications example unexplained vaginal bleeding acute liver damage liver dysfunction vascular embolization breast cancer contraindications hrt taken physicians adjuvant therapy review including range common chinese herbs formulations according existing literature provides general description treating pof aspects mechanisms clinical application also highlights acupuncture unique physiotherapy pof although validity supported evidence many preclinical trials clinical trials meta analysis adverse events therapy still exist guarantee made safety review concludes updated information treating pof contributing studies
premenstrual dysphoric disorder pmdd psychiatric disorder causes serious impairments functioning quality life affected women recently research efforts somewhat hampered lack formal diagnostic criteria codified category diagnostic statistical manual mental disorders fifth edition dsm better characterization deficits socioemotional functioning caused pmdd may aid improving treatment efforts investigation prospective symptom ratings based dsm criteria used measure pmdd symptoms women pmdd healthy controls two self report inventories emotion regulation questionnaire difficulties emotion regulation scale used measure ability regulate emotions socioemotional functioning measured inventories social connectedness perceived stress affect potential relationships ability regulate emotion pmdd symptom severity well measures socioemotional functioning affective state tested women pmdd reported significantly behavioral impulsivity greater difficulties regulating emotion socioemotional functioning cognitive behavioral strategies improve problems may benefit women pmdd help alleviate distress caused disorder
premise study recent commentary edwards bot proposed constraints imposed packing young leaves buds could explain positive association non entire leaf margins latitude thoroughly consider alternative explanations methods review logic evidence underlying six major hypotheses functional significance marginal teeth involving putative effects leaf cooling optimal support supply areas served major veins enhanced leaf margin photosynthesis hydathodal function defense herbivores bud packing key results theoretical empirical problems undermine hypotheses except support supply hypothesis implies thinner leaves non entire margins phylogenetically structured analyses across angiosperms yunque flora genus viburnum demonstrate non entire margins indeed common thinner leaves across angiosperms association leaf thickness non entire leaf margins stronger latitude conclusion outline synthetic model showing biomechanics hydraulics vein geometry rates leaf expansion length development within resting buds tied leaf thickness drive patterns distribution entire non entire leaf margins model accounts dominance entire margins tropics mediterranean scrub tundra non entire margins cold temperate deciduous forests tropical vines early successional trees entire leaf margins monocots spinose toothed leaves favored short statured evergreen trees shrubs primarily mediterranean scrub related semiarid habitats
prenatal development known extremely sensitive maternal environmental challenges study hypothesize body growth lactation gestation cattle reduce nutrient availability pregnant uterus consequences placental development fetal membranes growing heifers fully grown cows belgian blue breed compared determine effect body growth placental development furthermore fetal membranes lactating holstein friesian cows heifers compared study impact dam lactation compared dam body growth parturition calf birth weight body measurements dam calf recorded well weight total fetal membranes cotyledons intercotyledonary membranes cotyledons individually measured calculate surface individual cotyledon total cotyledonary surface per placenta total cotyledonary surface unaffected breed breedxparity interaction besides lower cotyledonary weight heifer placentas smaller total cotyledonary surface compared placentas cows respectively within breed fetal membranes heifers lower total weight lower intercotyledonary membrane weight compared cows cotyledon number found multiparous dams growing heifers higher cotyledon number greater proportion smaller cotyledons within breed parity effect intercotyledonary membrane weight cotyledon number individual cotyledonary surface found placental efficiency calf weight total cotyledonary surface similar heifers significantly higher multiparous compared multiparous dams respectively furthermore seasonal effect placental development found winter spring placentas smaller cotyledons summer fall placentas main findings present study lactation maternal growth gestation entail comparable nutrient diverting constraint might alter placental development however results suggest placenta able manage situation two potential compensation mechanisms early pregnancy placenta might cope establishing higher number cotyledons late gestation compensatory expansion cotyledonary surface suggested meet nutrient demand fetus
preprocessing data transmission recommended many sensor network applications reduce communication improve energy efficiency however constraints memory speed energy currently limit processing capabilities within sensor network paper describe ultra low power analog circuitry integrated sensor nodes create energy efficient sensor networks demonstrate concept present custom analog front end performs spectral analysis fraction power used digital counterpart furthermore show front end combined existing sensor nodes selectively wake mote based upon spectral content signal thus increasing battery life without missing interesting events achieve low power signal analysis using analog spectral decomposition block freeing digital computation resources higher level analysis experiments context vehicle classification show improved performance asp interfaced mote digital implementation
prepulse inhibition ppi behavioral test startle reflex response high intensity stimulus pulse inhibited prior presentation weak stimulus prepulse classic neural circuitry mediates startle response localized brainstem however recent studies point contribution structures involved higher cognitive functions regulating sensorimotor gating particularly forebrain regions innervated dopaminergic nuclei aim present study verify role dorsal striatum dopaminergic transmitting mediated receptors ppi test rats inactivation induced muscimol injection affect ppi ppi startle response although impaired locomotor activity caused catalepsy infusion like antagonist sch impaired ppi disturb startle response locomotor activity evaluated immediately ppi test antagonist microinjection sulpiride affect ppi startle response impaired motor activity results point important role probably mediated direct basal ganglia pathway modulation sensorimotor gating accordance clinical studies showing ppi deficits schizophrenia tourette syndrome compulsive disorders pathologies related basal ganglia dysfunctions
present study interdependent nature hydraulic parameters morphometric variables bedrock river study using dumpy level gps satellite images mathematical equations data set hydraulics morphometric variables bedrock channel named bhatajhor eastern india generated data set used find impulse response relations hydraulic variables find relations morphometric variables find relations hydraulic morphometric variables seven equations formulated based empirical study end seven empirical relations include two variables involve channel cross section dimensions area width mean depth maximum depth width depth ratio hydraulic radius slope hydraulic variables velocity kinetic energy stream power manning factor chezy factor shear stress observation shows relatively higher coefficient determination variables like velocity manning factor velocity chezy factor slope ratio hydraulic radius slope ratio
presented feed forward controller coordinates engine fueling purge event reduce air fuel ratio excursions controller employs linear parameter varying model estimate necessary changes fuel pulse width based hydrocarbon sensor located purge line synchronization purge fuel vapor arrival intake manifold fueling command realized using transport delay model proposed controller experimentally validated ford port injected engine ecoboost engine significant reductions air fuel ratio excursions achieved steady state engine operating conditions associated highway conditions
pressure injury guidelines recommend regular repositioning yet patients mobility repositioning patterns unknown observational study using activity monitors undertaken describe activity patterns hospitalized patients risk developing pressure injury vast majority participants time spent sedentary activity range followed light range patients changed posture median interquartile range time period range approximate times per hour although main focus pressure injury prevention repositioning study shows patients restricted mobility actually moving quite often therefore might appropriate focus attention pressure injury prevention strategies adequate nutrition appropriate support surfaces good skin care
pressure retarded osmosis renewable method power production salinity gradients generated significant academic commercial interest date successfully implemented large scale work investigate lower bound cost scenarios power generation pro evaluate economic viability build comprehensive economic model pro assumptions minimize cost power production thereby conclusively identifying operating conditions economically viable current state art pro membranes estimate minimum levelized cost electricity pro kwh seawater river water pairing kwh reverse osmosis brine wastewater kwh nearly saturated water river water production system pairing extremely high salinity greater water freshwater potential compete wind power currently kwh show two methods reducing cost via economies scale reducing membrane structural parameter find latter method reduces levelized cost electricity significantly increasing membrane permeability coefficient elsevier rights reserved
previous literature suggests children autism spectrum disorder asd higher prevalence excess weight typically developing children information addressing risk factor concordance asd children lacking used retrospective analysis children visited autism speaks autism treatment network atn center united states canada analysis occurred concurrently two research teams within atn found substantial agreement predictors weight children asd known correlates obesity typical children included asian hispanic ethnicities four medication groups psychopathological comorbidities aggression anxiety depression adhd symptoms similarities risk factors weight asd children allow use existing protocols weight interventions minimal modification saving resources otherwise spent pursuing new risk factors treatments
previous research documented playing violent video games various negative effects social behavior causes increase aggressive behavior decrease prosocial behavior contrast much less evidence effects prosocial video games present research experiments examined hypothesis playing prosocial relative neutral video game increases helping behavior fact participants played prosocial video game likely help mishap willing devoted time assist experiments intervened often harassment situation results showed exposure prosocial video games activated accessibility prosocial thoughts turn promoted prosocial behavior thus depending content video game playing video games negative effects social behavior positive effects well
previous research examined age contexts males females develop gender congruent stereotypes research indicates social experience may provide great influence presence stereotypes likely influenced development gender schemas current study interviewed children years sub rural midwestern university community females age males age individually asked boys girls particular occupations activities aggressive behaviors prosocial behaviors generally males tended express holding stereotypic beliefs indicating gender congruent expectations items one domains however females expressed multiple stereotypic beliefs four contexts social cognitive explanations phenomena discussed current study important addition existing literature preschool teachers parents alike might able assist children better develop activities behavioral habits gender related stereotypes fail develop
previous research found evidence academic benefits longer school years paper investigates one many potential costs increased school year length documenting dramatic decrease youth suicide months school session detailed analysis find potential explanations economic conditions weather seasonal affective disorder patterns explain decrease evidence suggests youth may face increased stress decreased mental health school session elsevier ltd rights reserved
previous research revealed mode delivery important attribute consumers selecting probiotic product therefore determining predictors consumers preferred mode delivery probiotics particular importance public health policy makers marketers developers probiotic products functional foods food supplements pharmaceuticals considered modes delivery study assess important determinants survey performed belgium adult volunteers percent inflammatory bowel disease ibd patients results indicate functional foods preferred mode delivery probiotics furthermore significant odds ratios obtained digestive health knowledge probiotics familiarity functional foods familiarity food supplements
previous research shown positive intergroup contact advantaged group discourage collective action among disadvantaged group members positive intergroup contact encourage advantaged group members take action behalf disadvantaged outgroups two studies investigated effects negative well positive intergroup contact study found negative positive contact heterosexual people associated sexual minority students engagement collective action via group identification perceived discrimination among heterosexual students positive negative contacts associated respectively less lgb lesbian gay bisexual activism study found negative contact via perceived discrimination predicted lgbt lesbian gay bisexual transgender students collective action intentions longitudinally positive contact predicted heterosexual cisgender students lgbt activism implications relationship intergroup contact collective action social change discussed
previous research shown hyperactivation ventral medial prefrontal cortex vmpfc rostral anterior cingulate cortex racc high cortisol corticotrophin ratio cort acth ratio neutral relaxed states predict relapse alcohol dependent patients studies shown vmpfc racc deactivation blunted cortisol release stress alcohol cues predictive time relapse relapse severity however previous study assessed relationship markers central peripheral nervous system dysfunction participants potential joint effects relapse risk forty early abstinent treatment engaged patients underwent laboratory experiment exposure neutral alcohol stress cues separate functional magnetic resonance imaging scan similar cue exposure neutral relaxed state cort acth ratio significantly associated vmpfc hyperreactivity neutral relaxing cues also hypoactivation response alcohol stress cues patients basal heart rate neutral cort acth ratio neutral vmpfc hyperreactivty associated risk relapse however abnormal vmpfc activation elevated cort acth ratio overlap predicting risk relapse dysfunctional vmpfc response sole significant predictor odds relapse joint model relapse risk findings suggest cort acth ratio may serve peripheral marker vmpfc brain dysfunction aberrant vmpfc responses need evaluation potential biomarker alcohol relapse risk clinical outcome studies
previous research shown young children deny able see agent whose eyes covered current study explored phenomenon experiment year olds denied could see affirmed could look doll whose eyes covered indicating demand mutuality seeing another looking another experiment year olds drew distinction see look facing doll human strong correlation children knowledge reciprocal pronoun adherence mutuality demand found results discussed respect children bias second personal encounters children relational concept persons elsevier inc rights reserved
previous studies reported life satisfaction positively associated time perspective mindfulness mindfulness may provide holistic integrates helps balance different time frames however studies performed date conducted eastern central europe given important cultural differences time management regions mediterranean countries purpose present study replicate studies assess association mindfulness sample young adults living province barcelona catalonia spain total undergraduate university students women recruited completed satisfaction life scale swls zimbardo time perspective inventory ztpi mindfulness attention awareness scale maas results show significant positive relationships mindfulness past positive well negative associations past negative unbalanced mindfulness also correlated inversely unbalanced regression analyses showed variance could explained past negative past positive ztpi measures together maas results confirm conclusions previous studies conducted culturally different populations reinforce hypothesis mindfulness provides holistic intrinsically balances increases findings suggest mindful attitude might key component regulation transcends different european cultural backgrounds
previous studies indicate gaseous messenger carbon monoxide released eye ophthalmic venous blood depending intensity sunlight study designed determine whether increased concentration ophthalmic venous blood affects synthesis melatonin therefore whether released eye normal lighting conditions carrier light intensity information thirty six mature male wild boar pig crossbreeds studied measured difference scotophase melatonin pathway response terms mean concentration increased melatonin levels hours infusion autologous blood plasma experimentally induced approximately fold increase concentration ophthalmic venous sinus demonstrated crossbreed marked variation duration amplitude nocturnal melatonin peak response increased concentration ophthalmic venous blood winter treatment limited nocturnal melatonin rise summer experimental treatment enhanced nocturnal melatonin rise changes melatonin levels always associated parallel changes aanat protein levels work demonstrates non physiological changes concentration ophthalmic venous blood acute impact systemic melatonin level results support humoral phototransduction mechanism bright light effects animal chronobiology treatment winter seasonal affective disorder
previous studies predicted european union attitudes using anti immigrant attitudes without explicitly accounting attitudes toward different groups propose group specific attitudes independently predict attitudes toward european union group linked european union issue question additionally argue realistic symbolic threat associated specific groups determines whether utilitarian identity considerations important predicting european union attitudes using nationally representative dutch sample focus attitudes toward polish muslim immigrants predict strengthening european union integration turkey potential accession find support hypotheses findings indicate need rethink relationship group perceptions european union attitudes
previous studies suggest providing employment services individuals serious mental illnesses help obtain competitive real world employment however services still easily accessible population paper provides brief summary recent federal initiatives may influence widespread implementation employment services increasing recognition need remove barriers provide supported employment services individuals mental illnesses wide spread coordination across federal polices financing regulatory changes necessary promote measurable lasting effects broad availability employment services among population
previous thermohydraulic studies performed iter magnet systems brought important information detection consequences quench function initial conditions deposited energy heated length even temperature margin correction coils high behavior quench also studied since quench likely triggered potential anomalies joints ground fault instrumentation wires etc model developed supermagnet code bagnasco side correction coil scc four pancakes cooled parallel represented thea module proper cable conduit conductor characteristics coils cooling loop hydraulically connected parallel top bottom correction coils six poloidal field coils modeled flower modules equivalent hydraulics properties model analysis results presented five quench initiation cases without fast discharge two quenches initiated heat input innermost turn one pancake case case two quenches initiated innermost turns four pancakes case case case quench initiated middle turn one pancake impact cooling circuit exceedance opening pressure quench relief valves detailed case undetected quench discharge magnet particular attention also paid possible secondary quench detection system based measured thermohydraulic signals pressure temperature helium mass flow rate maximum cable temperature achieved case fast current discharge primary detection voltage compared design hot spot criterion includes contribution helium jacket elsevier ltd rights reserved
previously identified anti talin antibodies serum case measured serum soluble talin stalin levels enzyme linked immunosorbent assay serum stalin levels significantly higher patients normal controls acute phase disease remission phase interestingly serum stalin levels associated sustained increase disability attack serum anti talin antibody levels stalin may biomarker acute phase may used short term prognosis elsevier rights reserved
primula veris important medicinal plant documented use treatment gout headache migraine reaching back middle ages triterpenoid saponins roots flowers used date phytotherapeutic treatment bronchitis colds due expectorant secretolytic effects addition wild type plants yellow petals red variant intermediate orange form primula veris recently found natural habitat secondary metabolite profiles roots leaves flowers rare variants investigated compared wild type metabolome two flavonoids six flavonoid glycosides four novel methylated flavonoid glycosides five anthocyanins three triterpenoid saponins identified alcoholic extracts petals leaves roots three variants high performance liquid chromatography hplc diode array detection dad mass spectrometry msn analyses anthocyanins detected petals red orange variety wild type effects metabolite profiles three varieties observed possibility discussed regulatory step anthocyanin biosynthetic pathway may affected mutation thus triggering color polymorphism petals
prion like propagation abnormal intracytoplasmic proteins defining features major neurodegenerative disorders alzheimer disease parkinson disease amyotrophic lateral sclerosis als proposed growing body evidence strongly suggests abnormal tau alpha synuclein tdp prion like properties convert corresponding normal proteins abnormal forms transmitted cell cell spreading throughout brain idea extremely important understanding pathogenesis progression diseases also development molecular therapies since distributions spreading abnormal proteins closely associated disease symptoms progression gain toxic function proteins may affect neurons glial cells either directly indirectly essential regulate aggregation abnormal intracellular proteins cell cell transmission order stop least slow progression diseases elsevier inc rights reserved
prior research demonstrated impact morality competence information impression formation study examines behavioral implications people initial impressions based information morality competence workplace school teachers employees asked form impression new school manager prospective boss presented high low morality high low competence results showed morality information rather competence information determined initial emotional responses new manager mediated willingness help newcomer adjust task social contexts results discussed terms theoretical practical implications future research directions outlined
prior research identified offline thoughts feelings behaviors lead impaired relationships individuals high social anxiety hsa fear conversation interpersonal aloofness tested whether social anxiety manifests visible online signals relationship impairment mirror known offline indicators whether observers use signals judging social anxiety online facebook profile owners reported social anxiety profiles coded objective features unacquainted observers rated profile owners social anxiety viewing profiles hsa individuals facebook profiles shown contain signs indicating relationship impairment across domains social inactivity friends photographs close relationship quality relationship status single self disclosure absence status updates observers inferred high levels social anxiety individuals whose profiles showed signs findings suggest offline relationship impairment experienced hsa individuals carries online contexts online relationship impairment accurately perceived unacquainted observers discussion considers whether integrating knowledge existing treatments notably online self guided protocols could improve identification treatment social anxiety elsevier ltd rights reserved
prior reviews behavioral treatments individuals comorbid alcohol drug use disorders substance use disorder sud posttraumatic stress disorder ptsd systematically considered whether comparison conditions matched target treatments time attention systematic literature search using pubmed mesh terms alcohol substance use disorders ptsd treatment identified relevant behavioral randomized clinical trials rcts evaluated ptsd oriented exposure based treatments addiction focused treatments coping based treatments involve exposure trauma memories information pertaining within subject changes time subject differences quality control condition recruitment efficiency assessment treatment retention synthesized alcohol drug outcomes described separately possible twenty four behavioral rcts identified exposure based addiction focused coping based seven studies included sud intervention comparison conditions matched target intervention time attention studies found participants experimental control conditions improved significantly time sud ptsd outcomes study found significant group differences sud ptsd outcomes favoring experimental treatment despite greater treatment dropout greater improvement ptsd outcomes exposure based interventions control conditions including control conditions matched time attention addiction focused coping based interventions generally show advantage comparably robust controls although coping based interventions yielded better drug use outcomes control conditions available interventions integrate exposure based ptsd treatment behavioral sud treatment recommended associated better ptsd outcomes sud care matched time attention however results critical review also suggest people sud ptsd benefit variety treatment options including standard sud care
prior available high dynamic range hdr techniques certain levels luminance could captured human eye currently hdr technology overcomes limitations conventional imaging technology also referred low dynamic range ldr allows capture delivery contents match dynamic range real world however state art hdr video focus mainly conventional sized displays typical tvs pcs usage mobile devices multimedia consumption increasing considerably need studying impact viewing hdr video devices allow take full advantage hdr technology creating set opportunities digital business allows among others presentation products much efficient captivating way paper presented study evaluates impact hdr video delivery mobile devices compares impact low dynamic range ldr content results show delivery hdr video mobiles possible without requiring much resources comparing delivery ldr video
prior unexpected early termination women health initiative whi trial continuous conjugated equine estrogens cee medroxyprogesterone acetate mpa prevailing view hormone replacement therapy hrt low risk intervention immediate value symptom relief recently menopausal women probably conferred long term protection major chronic diseases affect women menopause rather replicating prior studies whi designed test whether beneficial associations consistently seen women starting hrt near menopause would found women well beyond menopause views benefits risks hrt changed dramatically unexpected early termination cee mpa trial alarming initial whi report hrt use plummeted world wide driven fear breast cancer skepticism cardiovascular benefits stunningly contrasting findings whi trial cee alone reported years later suggesting prevention coronary heart disease women began hrt age years reduction breast cancer overall largely ignored key lessons whi effects hrt organ systems vary age time since last physiologic exposure hormones differences regimens years since first whi report learned much characteristics women likely benefit hrt range hrt regimens also increased women indications hrt initiate within years menopause benefits short term vasomotor dyspareunia long term bone health coronary risk reduction critically facts women clinicians consider making decision use use hrt frequently wrong incorrectly applied
prior work shows false memories resulting study associatively related lists reduced young older adults auditory presentation study list words accompanied related pictures relative auditory word presentation combined visual presentation word contrast young adults older adults show reduction false memories presented visual word along auditory word relative hearing word cases pictures relative visual words visual words relative auditory words alone benefit picture visual words reducing false memories explained terms monitoring perceptual information first experiment provide first simultaneous comparison study presentation modalities auditory auditory plus visual word auditory plus picture young older adults show reduction false memories auditory plus picture condition young adults show reduction visual word condition relative auditory condition second experiment investigates whether older adults fail show reduction false memory visual word condition encode perceptual information visual word condition addition second experiment provides evidence failure older adults show benefits visual word presentation related reduced cognitive resources
privacy image video data become important subject since cameras installed increasing number public private spaces specifically assisted living intelligent monitoring based computer vision allow one provide risk detection support services increase people autonomy home present work level based visualisation scheme proposed provide visual privacy human intervention necessary telerehabilitation safety assessment applications visualisation levels dynamically selected based previously modelled context way different levels protection provided maintaining necessary intelligibility required applications furthermore case study living room top view camera installed presented finally performed survey based evaluation indicates degree protection provided different visualisation models well personal privacy preferences valuations users
probabilistic load flow plf analyses probability behaviour power injected demanded electrical network providing cumulative results power flowing lines however probability behaviour analysis complete correlation load demands considered environmental social factors lead correlation paper proposes analytical method solve plf considering load demand correlation based use cumulants gram charlier expansion development proposed paper proved consistency method checked influence correlation solution plf shown elsevier rights reserved
probiotics living microorganisms providing health beneficial effect host probiotics used treatment prevention various diseases related diarrhea cholesterol immune function inflammatory bowel disease addition recent study also presents probiotic bacteria bifidobacterium lactobacillus genera able therapeutic effects patients psychological disorders depression anxiety memory lactobacillus casei gram positive bacterium naturally inhabits human animal gastrointestinal mouth organs name implies heterofermentative microorganism dominant species present ripening cheddar cheese probiotic aspects casei showed beneficial roles activation gut mucosal immune system treatment diabetics chronic constipation previous study isolated casei strain fermented dairy products showed immune regulatory functions especially therapeutic effect atopic dermatitis member complex probiotics order gain better insight probiotic effect atopic dermatitis analyzed genome sequence casei according report ncbi genome two hundreds lactobacillus organisms sequenced beneficial properties derived genomic information used food industry however available genomes casei strains members health promoting probiotics still insufficient furthermore casei strains frequently confused closely related strains lactobacillus paracasei lactobacillus rhamnosus therefore comparative study whole genome scale required clarify taxonomic association casei well functional characteristics availability genomic information casei aid basis depth analysis probiotic function casei strains
problem problem based learning pbl introduced parlance educational leadership management almost years ago ensuing decades global community professors doctoral students curriculum designers built upon early models goal increasing impact school leadership preparation systematic review literature addressed three questions scope composition literature pbl educational leadership preparation development learned implementation effects pbl educational leadership directions future research take domain method review employed quantitative analysis critical synthesis sources use pbl school leadership preparation development published findings literature problem based leadership preparation education consisted primarily descriptive studies pbl used individual programs courses progress identified terms developing suitable learning strategies curriculum designs educational leadership programs however compared literature pbl professional fields research literature domain remains immature significance first published review research use pbl school leader preparation development implications authors highlight need rigorous empirical research pbl also innovative approaches leader preparation education
problems aiming finding budget constrained optimal upgrading schemes improve network performance received attention last two decades general setting problems consist designing network simultaneously allocating limited upgrading resources order enhance performance designed network paper address two particular optimal upgrading network design problems cases sought layout corresponds spanning tree input network upgrading decisions taken nodes design mixed integer programming based algorithmic schemes solve considered problems lagrangian relaxation approaches branch cut algorithms along designed algorithms different enhancements including valid inequalities primal heuristic variable fixing procedures proposed using two set instances experimentally compare designed algorithms explore benefits devised enhancements results show proposed approaches effective solving optimality instances testbed manage obtain solutions bounds giving small optimality gaps besides proposed enhancements turn beneficial improving performance algorithms elsevier ltd rights reserved
problems high turbidity sedimentation water pollution siltation occur limboto lake gorontalo indonesia objective study analyze rainfall discharge relationship implications water quality conditions secchi disk water transparency chlorophyll chl total organic matter tom measured may september march three sites lake observe impacts surrounding catchment based representative stations rainfall data monthly averages rainfall march may september used represent wet dry period respectively moreover sediment traps three sites installed september based analysis suggested rainfall magnitude land use change alopohu river catchment influenced amount materials flowing lake degrading water quality specifically higher average rainfall may gave higher average total sediment load day addition water transparency decreased increasing chl indicates concentrations sediment nutrients reflected high amount chl influenced water quality conditions
problems identity formation associated range psychiatric disorders yet mechanisms underlying problems refined specific diagnostic presentations require investigation present study investigated identity processes among women eating disorders age matched community controls via newly developed identity model several clinical outcome variables assessed patients scored lower committing identifying identity related choices scored higher maladaptive ruminative exploration identity diffusion identity disorder also experienced less identity achievement compared controls identity disorder status associated highest scores anxiety depression borderline personality disorder symptoms non suicidal self injury lowest scores need satisfaction results indicate patients experience identity problems community controls captured identity disorder status experience problematic psychosocial functioning copyright john wiley sons ltd eating disorders association
process control courses usually section course focused building block diagrams modeling simulation analysis open closed loop processes purpose students often oriented build models using simulink xcos versatility powerful tools easy construction mathematical models using concept block oriented programming paper propose model library built software emso allows user create block diagrams process control studies emso powerful tool process modeling dynamic simulation optimization freely available academic purpose developed library analysis systems responses even complex processes carried pid controller tuning tasks made easier less time consuming students allowing advance study complex control strategies ratio cascade override feed forward among others students valued developed tool useful practical one favor control course learning process equivalent advantageous tool compared simulink xcos institution chemical engineers published elsevier rights reserved
processes like landslides debris flows bed load transport intersection natural environment human activity constitute increasing threat people property ability detect processes prematurely essential task mitigating hazards past studies shown debris flows debris floods emit detectable signals low frequency infrasonic spectrum induce characteristically seismic signals number monitoring devices detection methods identify debris flows using signals developed date warning system based combination seismic infrasound sensors considered previous studies already shown seismic infrasonic signals alpine mass movements correlated complementary combination two sensor types serve basis error resistant detection warning system work aims develop detection system detecting debris flows debris floods analyzing seismic infrasound waves system build minimum one seismic one infrasound sensor located microcontroller runs detection algorithm detect debris flows debris floods high accuracy real time directly site detection algorithm based analysis evolution time frequency content mass movement signal tested debris flows debris flood signals monitored different test sites austria switzerland paper describes current version detection system gives example event detection tyrolese test sites lattenbach dristenau farstrinne
prodromal symptoms psychosis associated increased risk transition functional impairment poor mental health unfavorable developmental prospects existing interventions targeting prodrome non satisfactory may thus promising attempt identify risk factors premorbid phase preceding prodrome increase chances successful preventive approaches investigate whether childhood mental disorders general attention deficit hyperactivity disorder adhd specifically indicate risk subsequent psychotic experiences disorders used sample prospective avon longitudinal study parents children participants years old mental disorders assigned according dsm standardized interviews psychotic experiences assessed age psychotic disorders age examined associations childhood mental disorders alone combination psychotic experiences age psychotic disorders age using logistic regression compared participants without disorder participants mental disorder higher risk psychotic experiences age psychotic disorders age particularly adhd combined subtype age strongly associated psychotic experiences age expected childhood mental disorders risk indicators psychotic experiences disorders improve prevention health care professionals need screen psychotic experiences children non psychotic disorders
product process platforms promoted possible enablers increased productivity civil engineering however platforms traditionally applied mass manufacturing industries production assets employed continuous production uniform products strongly facilitates continuous improvement discontinuous nature project based production civil engineering restricts possibilities thus platforms implemented need methods capable evaluating performance integrated product production process configurations specific projects possibility explored paper use database driven simulation case study configurable simulation model based standardized process patterns values stored platform developed production bridge concept presented results provide evidence database driven simulation support efficient platform evaluation development integrating product process information even discontinuous project based industrial sectors results specifically demonstrate approach used evaluate effects different configurations construction methods working time requirements without time consuming updates models
product manufacturers extending responsibilities whole life cycle providing services customers recent years product service system become important research topic address special requirements new service driven business model high value machine tools modern manufacturing factories special products regarded products maintenance point view also manufacture products new business model quality behavior machine tool affect quality parts manufactures also affect profits machine tool manufacturer however research area product service systems related computerized maintenance systems lack investigation special nature problems requirements high value machine tool maintenance important modern digitized manufacturing systems therefore research investigated various relationships different stakeholders machine tools lifecycle focusing knowledge management communication decision making processes research also explored potential application advanced content management systems widely implemented financial business government organizations manufacturing engineering domain dominated traditional engineering information systems prototype collaborative maintenance planning system proposed developed evaluated using example machine tool indicated significant improvement could achieved content management technology number advantages traditional engineering information systems computer aided engineering product data lifecycle management enterprise resource planning systems managing machine tool maintenance service information including dynamic unstructured knowledge elsevier rights reserved
progesterone neuroprotection striatal dopamine male mice lesioned methyl phenyl tetrahydropyridine mptp previously reported administered mptp hour dose mptp induce partial lesion used model early stages prodromal parkinson hypothesized brain restored progesterone administered early later days mptp male mice received injections mptp progesterone daily days started days mptp lesion decreased striatal metabolites serotonin contents mptp mice treated progesterone starting days mptp higher striatal metabolites content vehicle treated mptp mice striatal transporter dat vesicular monoamine transporter vmat specific binding decreased lesioned mice corrected progesterone treatment starting days mptp striatal glial fibrillary acidic protein gfap levels marker activated astrocytes elevated mptp lesion corrected progesterone treatment starting mptp striatal brain derived neurotrophic factor bdnf levels decreased mptp lesion prevented progesterone treatments whereas change akt gsk erk phosphorylated forms observed thus progesterone administered mptp mice protected dopaminergic neurons modulation neuroinflammation bdnf humans progesterone could possibly used disease modifying drug prodromal parkinson elsevier ltd rights reserved
progesterone produced corpus luteum regulates synthesis various endometrial proteins required embryonic implantation development compromised progesterone production potential risk factor prenatal development reactive oxygen species ros play diverse roles mammalian reproductive biology ros induced oxidative damage subsequent adverse developmental outcomes constitute important issues reproductive medicine considered highly exposed locally produced ros due high blood vasculature steroidogenic activity ros induced apoptotic cell death involved mechanisms regression occurs end non fertile cycle luteal ros production propagation depend upon several regulating factors including luteal antioxidants steroid hormones cytokines crosstalk however unknown factors greatest contribution maintenance integrity function oestrous menstrual cycle evidence suggest antioxidants play important roles rescue luteolysis pregnancy ensues luteal phase defect impacts fertility preventing implantation early conceptus development livestock humans review attempts address importance ros scavenging antioxidant enzymes control mammalian function integrity reproductive healthcare ltd published elsevier ltd rights reserved
program training social mobilization living semiarid one million rural cisterns pmc one largest programs rainwater harvesting human water supply underway brazil article presents assessment pmc point view users methodology based survey interviews municipalities reached programme depth interviews managers technicians users participant non participant observations image recording field works carried february july results indicate presence rainwater harvesting systems reduced almost total time spent search water results also showed highly precarious socioeconomic conditions still prevail limiting factor achievement program effectiveness program achieved goal building physical structures still significant challenges especially related adequate supply water quantity quality therefore public policies water supply semiarid rural areas associate technical issues management elements considering social climatic economic local conditions
programmable power sources widely used implement support wide range test procedure specifications tps traditionally power sources use analog control circuits provide key control protection functions like load regulation current limit frequency conversion proven design suffers number drawbacks advent recent advances dsp technologies full digital implementation power source design supporting high switching frequencies feasible paper discussed advantages derived digital implementation programmable poser source benefits provides ate system use
progranulin pgrn restrains inflammation therapeutic inflammatory arthritis however underlying immunological mechanism remains unknown study demonstrated antiinflammatory cytokine critical mediator pgrn mediated anti inflammation collagen induced arthritisbyusingpgrnandil geneticallymodifiedmousemodels greenfluorescentproteinreportermice revealed regulatory treg cells predominant source response pgrn addition pgrn mediated expansion activation treg cells well production depends jnk signaling known pgrn activated erk pik pathways furthermore microarray chromatin immunoprecipitation sequencing screens led discovery forkhead box protein signal transducer activator transcription transcription factors required pgrninduction treg cells findings define previously unrecognized signaling pathway underlies production bypgrnin treg cells present new insights mechanisms pgrn resolves inflammation inflammatory conditions autoimmune diseases particularly inflammatory arthritis shi mundra xiao dustin liu foxo stat dependent production progranulin regulatory cells restrains inflammatory arthritis
pro inflammatory cytokines tumor microenvironment known ability either inhibit promote cancer progression evaluated role interleukin protein belonging pro inflammatory cytokine family characterized autoimmune disease tumorigenesis show receptor ilra highly expressed various human mouse cancer cell lines well tumor specimens cancer patients murine colon carcinoma cells depleted exhibit increase invasive migratory properties vitro effects reversed supplementing cells exogenous vivo depleted tumor cells implanted mice grow faster control tumors contrast tumor bearing mice infused recombinant exhibit significant reduction tumor growth control mice furthermore infusion reduces number metastatic lesions lungs mice bearing murine metastatic breast carcinoma lastly injecting tumor bearing chemotherapy treated mice long lived igg fusion protein reduces tumor growth angiogenesis pulmonary metastasis greater extent chemotherapy used alone anti tumor activity explained part anti angiogenic effects demonstrated vitro vivo highlighting potential use anti cancer drug
project owners important project participants involved delivery green building projects virtue commitment owner commitment ensure successful delivery green building projects however indicators yet identified literature result information knowledge leads successful delivery green building projects currently unknown therefore study carried systematic literature review scholarly publications area project delivery green building projects identify indicators findings reveal indicators varying degrees importance depending frequency reference sources study concludes important indicators additionally indicators influence project performance cost time quality sustainability rating metrics thereby ensuring successful delivery green building projects findings study implications project owners green building projects therefore framework implementation proposed project owners apply framework guide commitment selection project participants design stage encouragements improved performance construction stage sequential manner future research explore confirm factor structure indicators order identify underlying relationships addition use effectiveness framework validated utilizing practical delivery green building projects elsevier ltd rights reserved
project scheduling important part project planning many management companies resource leveling problem describes process reducing fluctuations resource usage project duration goal resource leveling minimize incremental demands cause fluctuations resources thus avoid undesirable cyclic hiring firing project execution research novel optimization model named fuzzy clustering chaotic based differential evolution solving resource leveling fcde introduced fuzzy clustering chaotic based differential evolution fcde developed integrating original differential evolution fuzzy means clustering chaotic techniques tackle complex optimization problems chaotic exploited prevent optimization algorithm premature convergence meanwhile fuzzy means clustering acts several multi parent crossover operators utilize information population efficiently enhance convergence experimental results revealed new optimization model promising alternative assist project managers dealing construction project resource leveling
prolonged low grade inflammation smoldering inflammation hallmark cancer mast cells form heterogeneous population immune cells differences ultra structure morphology mediator content surface receptors mast cells widely distributed throughout tissues stromal components inflammatory microenvironment modulates tumor initiation development although canonically associated allergic disorders mast cells major source pro tumorigenic angiogenic lymphangiogenic factors antitumorigenic molecules tnf alpha depending milieu certain neoplasias gastric thyroid hodgkin lymphoma mast cells play pro tumorigenic role others breast cancer protective role whereas yet others apparently innocent bystanders seemingly conflicting results suggest role mast cells mediators could cancer specific microlocalization peritumoral intratumoral mast cells another important aspect initiation progression solid hematologic tumors increasing evidence certain experimental models indicates targeting mast cells mediators represent potential therapeutic target cancer thus mast cells deserve focused consideration also therapeutic targets different types tumors many unanswered questions addressed understand whether mast cells ally adversary innocent bystanders human cancers
properties granular materials molecular structures often studied simple geometric model set balls balls simultaneously change size constant speed topological properties empty space outside balls may also change capturing changes subsequent classification may reveal useful information model already solved balls size approximate solution reported balls different sizes solutions work simplicial complexes derived dual structure ordinary voronoi diagram ball centers use mathematical concept simplicial homology groups balls different radii appropriate use additively weighted voronoi diagram also known apollonius diagram instead ordinary diagram dual structure longer simplicial complex previous approaches used directly paper method proposed overcome problem method works voronoi edges vertices instead dual structure additional bridge edges introduced overcome disconnected cases output tree graph events cavities created merged simulated shrinking balls graph reorganized filtered according criteria get concise information development empty space model
property level stormwater drainage systems consist roof drainage systems systems connect buildings surrounding ground surfaces main sewer networks site rainwater harvesting capture systems design local systems traditionally based simplistic approaches fail account performance integration given extra demands associated climate change limitations take increasing importance due potential site level flooding water damage address concerns new tools needed describe assess performance well enable integrated approach research presented development integrated property level drainage simulation model associated whole life costing model application model illustrates importance accounting flow interactions order assess hydraulic effectiveness different adaptation schemes similarly whole life cost model determine life costs adaptation strategies hence enabling assessment cost effectiveness integrated designs
propranolol first used treat hemangioma efficacy safety since changed classical treatment indications infantile hepatic hemangioma presents spectrum clinical conditions varying simple asymptomatic lesions lethal complications tufted hemangioma kaposiform hemangioendothelioma congenital vascular tumors lead kasabach merritt syndrome hemangiomas like pure arteriovenous malformations cause hyperdynamic heart failure diffuse nodular type hemangiomas present hypothyroidism respiratory problems hepatic failure associated diffuse nodulartype liver hemangiomas spectrum approaches management varying watchful waiting liver transplant age propranolol prominent change infantile hepatic hemangioma treatment algorithm suggestion early treatment day propranolol plus day prednisolone patients protocol effective strategy type infantile hepatic hemangioma approximately one third patients abdominal compartment syndrome era propranolol treatment required liver transplant new treatment obviates transplant many patients
prosocial behavior refers voluntary actions intended help benefit individuals group individuals article revise experimental research prosocial behavior childhood first manifestations prosocial behavior begin appear first year life simple acts helping adult reach pencil fell floor pointing object adult looking later become complex diverse children begin share another individual resource disadvantage cooperate others achieve common goal experimental studies early middle childhood allow overview prosocial behavior stage life difficult behaviors children achieve provide emotional support someone sad frustrated altruistic acts would involve sacrifice child giving object improve welfare
prospective studies infant siblings children diagnosed autism spectrum disorder asd provide unique opportunity characterize asd unfolds critical question remains unanswered whether children asd resemble children identified community including family history purpose study compare clinical characteristics children asd identified method per group drawn two canadian longitudinal research cohorts children ascertained prospective cohort less severely affected included larger proportion girls compared clinically referred sample results may important implications conclusions drawn studies high risk clinically referred cohorts
protandim gingerol two potent nutraceuticals shown decrease free radicals production enhancing endogenous antioxidant enzymes study evaluated effects products expression different factors involved osteoarthritis process human chondrocytes treated presence absence protandim gingerol induced surgically mice destabilization medial meniscus dmm animals treated weekly intraarticular injection vehicle protandim weeks sham operated mice served controls vitro demonstrated protandim gingerol preserve cell viability mitochondrial metabolism prevented hydroxynonenal hne induced cell mortality activated nrf transcription factor abolished induced pge mmp hne production well induced gsta regulation nrf overexpression reduced induced hne mmp well induced gsta regulation nrf knockdown following sirna transfection abolished protandim protection oxidative stress catabolism activation mapk affected gingerol vivo observed nrf gsta expression significantly lower cartilage humans mice compared normal controls interestingly protandim administration reduced score dmm mice altogether data indicate protandim gingerol essential preserving cartilage abolishing number factors known involved pathogenesis cell biochem wiley periodicals inc
protein secondary structure prediction important problem bioinformatics transforming biomedical big data valuable knowledge also quite interesting challenging task various machine learning algorithms widely applied bioinformatics extract knowledge protein data recent years multilayer perceptron emerging basis artificial neural networks making major advances many domains paper focused analysing machine learning based multilayer perceptron mlp algorithms protein secondary structure prediction using different set input features network parameters distributed computing environment overall mlp analysis results classifying protein secondary structures encouraging accuracy performance overwhelming passing various input features outperforms implemented various distributed environment experimental result shows multilayer perceptron machine learning algorithm models outperforms machine learning approaches
proteins responsible multiple biological functions ligand binding catalysis ion channeling functionality enabled proteins three dimensional structures require long polypeptides since plausibly prebiotic synthesis functional polypeptides proven challenging laboratory propose functions may initially performed alternative macromolecular constructs namely hyperbranched polymers hbps early stages chemical evolution hbps straightforwardly synthesized one pot processes possess globular structures determined architecture opposed folding proteins documented ligand binding catalytic properties initial study focuses glycerol citric acid hbps synthesized via moderate heating dry state polymerization products consisted mixture isomeric structures varying molar mass evidenced nmr mass spectrometry size exclusion chromatography addition divalent cations polymerization resulted increased incorporation citric acid hbps possible formation cation oligomer complexes chelating properties citric acid govern makeup resulting polymer turning polymerization system rudimentary smart material
proteomics passed tremendous development recent years development ever sensitive fast precise mass spectrometry methods dramatically increased research biology mitochondria prominent involvement kinds diseases ageing benefitted mitochondrial proteomics review substantial findings progress proteomic analyses human cells tissues recent past one challenge investigations human samples ethically medically founded limited access human material increased sensitivity mass spectrometry technology aids lowering hurdle new approaches like generation induced pluripotent cells somatic cells allow produce patient specific cellular disease models great potential describe human sample types accessible review status catalog human mitochondrial proteins discuss proteins dual localization mitochondria cellular compartments describe status developments pertinent mass spectrometric strategies use databases bioinformatics using selected illustrative examples draw picture role proteomic analyses many disease contexts inherited disorders caused mutation mitochondrial proteins complex diseases like cancer type diabetes neurodegenerative diseases finally speculate future role proteomics research human mitochondria pinpoint fields evolving technologies exploited published elsevier behalf mitochondria research society
providing healthy school environment priority child health aim study develop methodology allows quantification potential economic benefit reducing indoor exposure nitrogen dioxide children attending primary schools using environmental health data collected primary schools london study estimates average asthma exacerbations per school averted year reducing outdoor concentrations study expands upon previous analyses two ways first assesses health benefits reducing children exposure indoor school second considers children perspective economic evaluation using willingness pay approach study quantifies monetary benefits reducing children indoor exposure school would range pound per school child perspective based child budget adopted pound parent perspective considered study highlights designers engineers policymakers stakeholders need consider reduction outdoor pollution particularly levels near primary schools may substantial health monetary benefits published elsevier ltd
provision uniform query interface facade access health care data present multiple data stores used autonomously various departments hospital empower health care community make better decisions conclusions one naive approach implementation system use one popular database store process data pertaining departments hospital nonetheless single data model efficiently store process multitude data generated healthcare institutions example data fit well row column format traditional relational databases however modern nosql data stores allow data stored form closer actual representation usage storage retrieval data disparate data stores challenges issues like dealing multiple querying languages understanding different data modeling techniques creation maintenance knowledge base data kbod developed intelligent information integration solution named polyglot persistent healthcare information system polyglothis makes use cooperating agents enabling health care professionals retrieve data heterogeneous data stores polyglothis uses multiple data stores storage processing data rationale select appropriate data storage technology meets specific requirements module architecture polyglothis consists primarily multiple cooperative agents capabilities contents data stores stored inferred using datalog declarative logic programming language used store set facts rules design working principle polyglothis illustrated help running example performance analysis implemented system showcase less latency induced system
psa immune mediated chronic inflammatory disease affects skin joints heterogeneous disease characterized synovitis enthesitis dactylitis spondylitis impact patients burden disease substantial assessment disease patient reported outcomes increasingly important conventional therapy consists nsaids local systemic css synthetic biological dmards mtx lef ssz cyc synthetic drugs mainly used tnf alpha blocking agents represented majority biologics used last decade infliximab etanercept adalimumab certolizumab golimumab treat target strategies used successfully psa review concentrates new developments mainly covering biologic agents inhibitor secukinumab anti agent ustekinumab also synthetic drugs including novel phosphodiesterase inhibitor apremilast janus kinase inhibitor tofacitinib blocks mainly jak jak lesser extent jak efficacy new agents may even better skin joints
psoriasis chronic auto immune inflammation disease skin lesions abnormal keratinocyte proliferation axis plays important role pathogenesis psoriasis madecassoside mad important constituents isolated centella asiatica long used dermatology supposed mad may effects psoriasis present study balb mice ear back skin received imq consecutive days induce psoriasis like dermatitis mad ointment applied later imq treatment pathway investigated staining brdu psoriasis area severity index pasi used score severity keratinocyte proliferation inflammation skin real time pcr western blot used detect related cytokines flow cytometry applied observe numbers cells daily application imq days mouse ear skin back skin induced psoriasis like dermatitis real time pcr showed mrna level significantly decreased mad ointment treatment ear skin staining brdu incorporation implied mad ointment reduced keratinocyte proliferation flow cytometry results showed mad ointment decreased numbers cells thus mad ointment ameliorates imiquimod induced skin inflammation abnormal keratinocyte regulate axis elsevier rights reserved
psoriasis common chronic inflammatory immune mediated skin disease antagonists tnf alpha recently proven highly effective treatment psoriasis however molecular mechanisms involved pathogenesis psoriasis poorly understood recently presented evidence kappa zeta key regulator development psoriasis role mediating driven effects like produced variety immune cells expression increased psoriatic skin purpose study characterize role regulation kappa zeta expression investigate whether regulates psoriasis associated genes human keratinocytes kappa zeta demonstrate stimulation induces kappa zeta expression mrna protein levels normal human keratinocytes moreover silencing kappa zeta sirna revealed kappa zeta key regulator specific inducible psoriasis associated genes proteins including defb hbd ccl chil addition induced kappa zeta expression mediated mechanism involving mapk kappa signalling pathways shown clear reduction mediated expression kappa zeta chemical inhibition two signalling pathways summary present kappa zeta novel key regulator driven effects psoriasis thus antagonists kappa zeta could potentially provide targeted approach treating psoriasis well treating inflammatory immune mediated diseases targeting drugs recently approved
psoriasis common inflammatory skin disease exact pathogenesis largely unknown interleukin demonstrated vital role cell mediated immune response interacting keratinocytes pathogenesis psoriasis showed differentially expressed mirnas potential targets hacat cells stimulated using mirna mrna microarrays revealed total significantly changed twofold mirnas hacat cells validated results quantitative reverse transcriptase pcr qrt pcr demonstrated mir regulated hacat cells stimulated psoriatic lesions aimed investigate biological roles potential mechanism mir keratinocytes result cck assay indicated overexpression mir keratinocytes promoted proliferation conversely inhibition endogenous mir suppressed proliferation according microarray analysis assumed sprouty spry negative regulator extracellular signal regulated kinase mitogen activated protein kinase signalling pathway direct target gene mir found staining spry cytoplasm mainly localized basal suprabasal layers epidermis showed markedly decreased expression psoriasis normal control immunohistochemistry luciferase reporter western blot assays hacat cells demonstrated spry direct target gene mir conclusion induced mir promotes keratinocyte proliferation possibly downregulating expression spry thus playing important roles pathogenesis psoriasis
psoriasis characterized hyperproliferation deregulated differentiation impaired apoptosis keratinocytes mechanisms lipid profile disturbances metabolic syndrome psoriatic patients still fully understood sphingolipids namely ceramides cer sphingosine phosphate signal molecules regulate cell growth apoptosis immune reactions aim study evaluate circulating cer levels plaque type psoriasis associations disease activity inflammatory metabolic markers presence psoriatic comorbidities eighty five patients exacerbated plaque type psoriasis thirty two healthy controls enrolled serum cer concentrations treatment examined general patient characteristics included pasi psoriasis area severity index bmi body mass index inflammatory biochemical markers lipid profile presence psoriatic comorbidities total serum concentration cer significantly decreased concomitantly levels significantly increased psoriatic patients compared healthy control group among patients psoriasis significant correlations disease activity inflammation markers observed patients psoriatic arthritis significantly higher cer total concentration serum sphingolipid disturbances psoriatic patients observed decreased total cer increased serum levels may reflect epidermal altered composition metabolism patients psoriatic arthritis higher cer levels psoriasis skin involvement might provide additional predictive value psoriatic arthritis may convey higher risk metabolic cardiovascular disease development group patients
psoriasis patients determined high ratio coronary artery calcification fetuin osteoprotegerin systemic calcification inhibitors related vascular calcification cardiovascular mortality study investigated relationship fetuin osteoprotegerin levels psoriasis patients study included healthy volunteers psoriasis patients venous blood collected healthy volunteers psoriasis patients order search fetuin osteoprotegerin levels disease severity grouped mild moderate severe according psoriasis area severity index pasi relationship fetuin osteoprotegerin levels clinical features sex pasi presence psoriatic arthritis analyzed fetuin levels psoriasis patients statistically lower control group serum fetuin osteoprotegerin level differences statistically significant patients psoriatic arthritis history without grouped patients respect sexes fetuin osteoprotegerin levels males females significantly different correlation detected ages pasi scores fetuin osteoprotegerin levels patients result fetuin levels psoriasis patients found low related disease severity light results concluded fetuin may role psoriasis pathogenesis may contribute calcification process developed psoriasis
psoriasis skin lesions characterized dramatic changes transcriptome reflecting altered activity multiple signalling pathways resident infiltrating cells mirnas small non coding rnas large impact cellular functions regulating multiple genes simultaneously shown play key roles skin homoeostasis inflammation commentary review article micrornas psoriasis immunological functions potential biomarkers liu etal role mirnas psoriasis diagnostic therapeutic potential discussed remaining unanswered questions highlighted
psoriasis chronic immune mediated skin disease characterized red scaly plaques affects approximately population japan aim open label study evaluate long term efficacy safety ixekizumab humanized anti interleukin monoclonal antibody japanese patients plaque psoriasis including psoriatic arthritis erythrodermic psoriasis generalized pustular psoriasis ixekizumab administrated baseline week weeks every weeks weeks every weeks week patients plaque psoriasis achieved psoriasis area severity index pasi achieved pasi achieved pasi remission plaques static physician global assessment spga difficult treat areas psoriasis nail scalp also responded ixekizumab patients psoriatic arthritis assessed achieved american college rheumatology response patients erythrodermic psoriasis generalized pustular psoriasis responded ixekizumab clinical outcome maintained weeks patients achieved spga week respectively mostly mild moderate treatment emergent adverse events reported patients common nasopharyngitis eczema seborrheic dermatitis urticaria injection site reactions conclusion week ixekizumab treatment efficacious well tolerated japanese patients plaque psoriasis efficacy also observed patients erythrodermic psoriasis generalized pustular psoriasis psoriatic arthritis
psoriatic arthritis psa psoriasis associated inflammatory joint disease affects peripheral joints entheses spine eyes psa likely disease psa develops nearly patients hallmark disease bone erosions bone formation innate adaptive immunity appear contribute pathogenesis psa trauma may trigger factor psa cell clones reported present synovial tissues skin lesions suggesting common antigen drives cell immune response joints skin lesions patients psa axis plays critical pathogenic role psa biologics neutralizing effective therapies psa differential expression cytokines various sites could explain different manifestations disease highly expressed peripheral joints skin lesions causes bone erosions highly expressed skin lesions entheses peripheral joints cause bone formation finally mannan baker yeast caused psa like arthritis like skin lesions blocked treatment data suggest psa likely disease exhibiting different manifestations depending local cytokine production elsevier rights reserved
psoriatic arthritis chronic inflammatory joint disease occurring subgroup patients suffering psoriasis article gives overview complexity psoriatic arthritis looking several aspects heterogeneous disease epidemiology important clinical features comorbidities well current concepts pathophysiology subsequent insights novel treatment targets
psoriatic arthritis part family diseases referred spondyloarthropathies diverse group chronic inflammatory disorders common clinical radiographic genetic features peripheral arthritis common symptom psoriatic arthritis patients also frequently experience involvement entheses spine skin nails due diverse clinical spectrum disease severity tissues affected associated comorbidities treatment psoriatic arthritis challenging necessary mitigate risks associated disease treatment risks include disease specific treatment related psychological risks disease specific risks include associated disease progression limit functional status mitigated early diagnosis initiation treatment risks also arise comorbidities associated psoriatic arthritis cardiovascular disease obesity diabetes mellitus gastrointestinal inflammation patient outcomes affected treatment strategy employed pharmacologic agents administered additionally important physicians aware risks specific therapeutic option impact psoriatic arthritis limited skin joints common patients experience quality life impairment patients also likely depression anxiety alcoholism article reviews many risks associated psoriatic arthritis provides guidance mitigating risks
psychiatry research long experienced stagnation stemming lack understanding neurobiological underpinnings phenomenologically defined mental disorders recently application computational neuroscience psychiatry research shown great promise establishing link phenomenological pathophysiological aspects mental disorders thereby recasting current nosology biologically meaningful dimensions review highlight recent investigations computational neuroscience undertaken either theory data driven approaches quantitatively delineate mechanisms mental disorders theory driven approach including reinforcement learning models plays integrative role process enabling correspondence behavior disorder specific alterations multiple levels brain organization ranging molecules cells circuits previous studies explicated plethora defining symptoms mental disorders including anhedonia inattention poor executive function data driven approach hand emerging field computational neuroscience seeking identify disorder specific features among high dimensional big data remarkably various machine learning techniques applied neuroimaging data extracted disorder specific features used automatic case control classification many disorders reported accuracies reached however note rigorous tests independent cohorts critically required translate research clinical applications finally discuss utility disorder specific features found data driven approach psychiatric therapies including neurofeedback developments allow simultaneous diagnosis treatment mental disorders using neuroimaging thereby establishing theranostics first time clinical psychiatry
psychological research provided essential insights stigma operates disadvantage targeted time stigma research criticized focused perceptions stigmatized individuals microlevel interactions rather attending structural forms stigma article describes relatively new field research structural stigma defined societal level conditions cultural norms institutional policies constrain opportunities resources well stigmatized review emerging evidence structural stigma related mental illness sexual orientation exerts direct synergistic effects stigma processes long focus psychological inquiry concealment rejection sensitivity serves contextual moderator efficacy psychological interventions contributes numerous adverse health outcomes members stigmatized groups ranging dysregulated physiological stress responses premature mortality indicating structural stigma represents underrecognized mechanism producing health inequalities pieces evidence suggests structural stigma relevant psychology therefore deserves attention psychological scientists interested understanding ultimately reducing negative effects stigma
psychological stress induced trier social stress test tsst repeatedly shown alter memory performance although factors influencing memory performance stimulus nature verbal pictorial emotional valence extensively studied results whether stress impairs improves memory still inconsistent study aimed exploring effect tsst item versus associative memory neutral verbal pictorial stimuli healthy subjects recruited participants randomly assigned tsst group remaining participants assigned control group stress reactivity measured psychological subjective state anxiety ratings physiological galvanic skin response recording measurements subjects performed item association memory task stimulus types words pictures simultaneously stress non stress manipulation results showed memory recognition pictorial stimuli higher verbal stimuli memory words pictures impaired following tsst source impairment specific associative recognition pictures general deficit observed verbal material expressed decreased recognition items associations following tsst response latency analysis indicated tsst manipulation decreased response time cost memory accuracy conclude stress uniformly affect memory rather interacts task cognitive load stimulus type applying current study results patients diagnosed disorders associated traumatic stress findings healthy subjects acute stress provide support assertion patients impaired memory originates poor recollection processing following depletion attentional resources
psychologists long assumed connection traumatic experience psychological dissociation hypothesis referred trauma model dissociation past decade series papers published question traditional causal link proposing alternative fantasy model dissociation present research relationship among dissociation suggestibility fantasy proneness examined suggestibility measured gudjonsson scale interrogative suggestibility gss well autobiographically based version measure based events september consistent prior research trauma model dissociation correlated positively trauma severity fantasy proneness inconsistent fantasy model dissociation correlate neutral form gss correlated negatively trauma focused form suggestibility measure although participants become quite emotional procedure risk benefit ratio perceived almost participants positive reactive individuals evaluating procedure positively results consistently support trauma model dissociation fail support fantasy model dissociation
psychopathy popularly conceptualized includes personality features callousness lack remorse shame manipulativeness pathologic egocentricity imply impediments formation traditional social bonds however suggested individuals psychopathic traits may affected social context may fuel engagement antisocial activity kerr van zalk stattin martens adolescents inherently susceptible social influences developmental stages especially important understand role interpersonal context particularly among youth psychopathic traits study examines whether psychopathic traits moderate relation antisocial influence peers parents important nonparental adults institutional self report official records offending sample serious juvenile offenders southern california results indicate greater exposure antisocial influence peers important nonparental adults translated delinquent behavior among youth current study impact peer influence institutional misconduct particularly pronounced youth high psychopathic traits findings imply taking youth social environment account paramount examining importance psychopathic traits adolescent antisocial behavior
psychosocial rehabilitation programs received mental health professional support addition traditional medication therapy many psychosocial programs developed since including cognitive remediation therapy review focus cognitive remediation therapy korea since review several cognitive rehabilitation programs developed korea outcome studies suggest future research directions prospects reviewed cognitive rehabilitation programs including social cognitive training well recent forms computerized cognitive rehabilitation although differences cognitive domains training targets almost neurocognitive remediation trainings korea beneficial effects early visual processing various attention types executive function future studies need investigate mechanisms various mediators underlying relationships cognitive functions functional outcomes comprehensive cognitive social cognitive programs enhance cognition functional outcomes patients schizophrenia elsevier rights reserved
public health insurance china children analyzed using equity analysis framework compared public health insurance low income children four dimensions comparisons addressed fairness financial support equal treatment equal need equality access services equality health outcomes secondary data china government statistics used comparisons recommendations strengthen china health insurance children include lower pocket expenses standardized data collection management qualified nurse practitioners providing rural health care explicit coverage requirements
public key infrastructure pki widely used security mechanism securing communications network however known performance issues making unsuitable use vehicular networks paper propose secure authenticated key management protocol sakmp overcome shortcomings pki kmp scheme distributes repository containing bindings entity identity corresponding public key vehicle road side unit certificate exchanges certificate revocation lists eliminated furthermore kmp scheme uses symmetric keys derived based matrix based key agreement scheme reduce high computational costs using asymmetric cryptography demonstrate efficiency kmp performance evaluations terms transmission storage overhead network latency key generation time analytical results show kmp scalable outperforms certificate based pki simulation results indicate key generation time kmp scheme less existing elliptic curve diffie hellman diffie hellman protocols addition use proverif prove kmp scheme secure active attacker dolev yao model show kmp scheme secure denial service collusion attacks wide range malicious attacks
public key infrastructure pki based public key certificates widely used mechanism trust key management however standard pki validation revocation mechanisms considered major reasons unsuitability delay disruption tolerant networking dtn dtn requires mechanism authenticate messages node forwarding network certificate revocation lists crls distributed dtn network need authenticated validated issuer certificate authority node study authors propose new validation revocation mechanism compliant dtn semantics protocols study also proposes new design crl compliance standard pki standard make proposed mechanism easy implement dtn new designed crl reduced size contains fewer entries compared standard crl also arranges revocation list form hash table map increase searching efficiency
pulmonary fibrosis associated number specific forms interstitial lung disease ild lead progressive decline lung function poor quality life ultimately early death idiopathic pulmonary fibrosis ipf common fibrotic ild affects elderly individuals median survival ranges years following initial diagnosis ipf shown respond immunomodulatory therapies recent trials novel antifibrotic agents demonstrated lessening lung function decline time pirfenidone shown significantly slow decline forced vital capacity fvc time prolong progression free survival led licensing united states food drug administration fda treatment patients ipf however pirfenidone associated significant side effects patients treated pirfenidone must carefully monitored review recent ongoing clinical research experience pirfenidone pharmacologic therapy patients ipf provide suggested approach incorporate pirfenidone treatment algorithm patients ipf examine potential pirfenidone treatment non ipf forms ild accompanied progressive pulmonary fibrosis
pulmonary manifestations seldom recognized symptoms storage disorders report describes diagnostic journey month old male infant born third degree consanguineous marriage referred institute severe persistent asthma history revealed child progressively worsening breathlessness persistent dry cough associated fever accompanied weight loss physical examination growth failure respiratory distress clubbing hepatosplenomegaly occasional rhonchi blood gas revealed hypoxemia improved oxygen administration plain rays high resolution computed tomography chest showed perihilar alveolar infiltrates patchy consolidation clinicoradiological features support diagnosis asthma favored interstitial lung disease ild bronchoalveolar lavage performed first tier investigation showed periodic aciduschiff negative foamy macrophages clues consanguinity visceromegaly ild foamy macrophages bronchoalveolar fluid prompted consideration lysosomal storage disorders likely etiology gaucher disease niemannupick disease ruled enzyme estimation niemannupick disease type suspected confirmed detecting homozygous mutation npc gene case serves caution physicians labeling breathlessness every toddler asthma emphasizes importance searching tell tale signs clubbing extrapulmonary clues point systemic disease lysosomal storage disorders primary etiology chronic respiratory symptoms
pulp paper mills indispensable nation far growth nation concerned due fast growth population urbanization industrialization demand consumption paper increased tremendously put high load natural resources force industry look alternative raw material rice straw lignocellulosic material abundantly available wood short countries like china india bangladesh etc used raw material industry open burning rice straw releases noxious green house gases air poses serious threats global air chemistry human health dual benefit option farmers industries use rice straw raw material pulp paper industry organosolv pulping using acids prominent choices researchers convert residue valuable pulp developed countries developing world favours soda soda processes economical virtue less lignin content comparison wood rice straw requires less harsh conditions cooking easily pulped bleaching crucial step paper making also responsible causing water pollution many studies revealed process chlorinated compounds released highly toxic bioaccumulative carcinogenic nature industries globe switch elemental chlorine free short sequence bleaching methods using chlorine dioxide hypochlorite hydrogen peroxide paper presented effective need ecofriendly economically reliable pulping bleaching sequences case rice straw eliminate problems chlorinated compounds wastewater paper mills approach using waste raw material environmentally safe processing making paper prove valuable towards sustainable growth elsevier ltd rights reserved
purpose number postmodern consumer scholars attention consumption behaviour neo tribes changing gender roles households consumption practices also shaped new sets cultural manifestations clothing consumption milieu purpose paper explore clothing consumption culture neo tribe gay professionals within subculture gay consumers design methodology approach extended conceptual framework built upon ajzen fishbein theory reasoned action served conceptual guideline study specifically attitude behaviour framework proposed employed better understand clothing consumption behaviour neo tribe consisting gay professionals personal depth interviews conducted metropolitan city well two small towns canada findings stereotypical well non stereotypical understandings offered findings study portrayed gay professions neo tribe rational practical personal psychological factors social factors marketplace factors relevant neo tribe gay professionals documented deeper insights presented research limitations implications findings challenge existing understanding fashion manifestation consumers group however study may limited scope future studies examine clothing consumption cultural manifestations neo tribes within gay community practical implications interviewees consistently demonstrated positive attitudes towards quality stylish conservative clothing marketers crucial perceive gay community non homogeneous market segment need understand different consumption practices within community tailor marketing mix elements accordingly originality value study extended understanding neo tribes gay consumers addition study offers clothing consumption reality neo tribe encompassing gay professionals study illuminates rational practical clothing consumption cultural manifestations clothing consumption behaviour insights enrich general understandings exist area consumer research
purpose although studies student residential satisfaction abound yet limited studies conducted students satisfaction respect hostel accommodation facilities undertaken public private partnerships ppps nigeria purpose study assess level students satisfaction provision university hostel accommodation facility using build operate transfer bot model university lagos unilag nigeria design methodology approach study adopted literature review questionnaire survey within case study bot hostel accommodation facility unilag nigeria students reside case study respondents hence self administered questionnaires purposively distributed face face entire student population live bot hostel thus total completed questionnaires representing per cent collected found suitable analysis data collected analysed using mean score chi square test findings study revealed total mean satisfaction level point likert scale indicates students somehow satisfied university hostel accommodation facility undertaken bot study established age level students significant influence overall students satisfaction hostel accommodation facility undertaken bot practical implications study would provide valuable feedback private investors university authorities facility managers higher education institutions improve services near future originality value identified variables tested significant assessing students level satisfaction bot hostel accommodation facilities could used assess users satisfaction similar facilities delivered ppps countries
purpose building information modelling bim technology well received malaysian construction industry yet adoption rate extremely slow many areas adoption issues know regarding bim investigated however prior research considered perspective engineering consulting services ecs firms therefore purpose paper explore overview adoption bim perspective malaysian ecs firms objectives first determine perceptions barriers governmental support intentions adopting bim second identify key drivers adopting bim within two years design methodology approach primary data collected focus group interview questionnaire survey achieve first objective subsequently second objective achieved based pearson relationship analysis findings results show firms concept bim equates industry authorities norms yet lack well trained personnel guidance governmental supports identified main barriers adoption nevertheless firms prepared adopt bim market demands competitive advantage main drivers adoption within two years originality value different perspective highlighted adoption bim renders new insight effective adoption use bim ecs firms perspective
purpose due increase traffic issues appearing electrified railway feeding systems one candidate solution solve issues improve performances add storage systems railway electrical network purpose paper present method based optimal power flow opf analysis design railway feeding systems storage design methodology approach paper describes new methodology based optimization study electrified railways including storage systems load flow model railway electrification system presented including mobility train sets opf model network including energy storage systems feeding substation rectifiers developed finally opf model tested real application case showing benefits searching solutions order improve network performances findings opf model suitable analysis networks storage presented shows ability solve large scale problems research limitations implications paper focusses physical model network optimization model extended application constraints originality value hypothesis presented paper allows remove discontinuities system order use continuous optimization approach
purpose knowledge technology transfer ktt particularly academic entrepreneurship klofsten jones evans indispensable economic growth wealth creation many european countries including germany substantially fewer women men participate ktt recently decision makers scientific political commercial organisations increased attention gender dimension moser schiebinger purpose paper evaluate ways degree gender currently integrated german ktt design methodology approach following abductive approach suddaby building upon existing models klofsten jones evans carlsson lundvall authors developed analytical framework evaluating position gender dimension ktt conducted comprehensive literature review key informant interviews findings findings indicate gender dimension barely integrated german ktt particularly manifests fact fewer per cent women among academic entrepreneurs current organisational practices attitudes decision makers continue reinforce traditional gender roles typically male approaches behaviours connell redien collot originality value authors first synthesise variety sources one unified framework rigorously analyse gender dimension german ktt quantitatively qualitatively different levels framework help decisions makers outside germany envision ktt practices create new opportunities diverse participants
purpose surface roughness important parameter manufacturing engineering significant influence performance mechanical parts failures sometimes catastrophic failures leading high costs imputed component surface roughness owing need improvement machining parameters order obtain prescribed surface roughness new developments recently investigated work aims report study optimisation model based genetic algorithms gas design methodology approach developed algorithm considers machining parameter data population obtained experimental tests exchange structured information based natural selection principles survival fittest allows combination solutions sequence generations leading best solution findings standard experimental design methodologies proposed approach shows advantages finding optimal conditions imposed constraints indeed quality produced surface roughness evaluated using criterion method determines combined effects input parameters optimal machining parameter originality value new methodology determining optimal machining parameters dry turning based measurement surface roughness proposed numerical experimental developed model used success applications industrial interest
purpose construction industry today one biggest industries world projects continue grow complexity project management continues evolve contractor selection difficult task owners project managers face although previously researchers worked subject contractor selection comprehensive decision support system contractor selection yet developed recent reports major delays cost overruns mega projects highlight need model able flexible comprehensive becomes evident paper aims discuss issues design methodology approach research focuses obtaining insights field experts using quantitative qualitative methods model developed light data collected accordingly model tested case study findings paper presents model contractor selection wholesome take topic model incorporates managerial technical aspects problem model tested case study proven feasible real world applications contractor selection decision support system serves needs academics industry managers integral part project management originality value model presented paper innovative take problems mcda tools uniquely modified paper cater needs selection problem accounting criteria hierarchy incorporates aspects instrumental proper evaluation contractor likelihood success
purpose losses incurred ferromagnetic materials pwm excitations must predicted accurately optimize design modern electrical machines purpose paper employ mathematical hysteresis models classical preisach model predict iron losses electrical steels pwm excitation without compromising computational complexity model design methodology approach paper novel approach based dynamic inverse preisach model proposed model iron losses pwm magnetic flux density waveform decomposed harmonic component using fourier series weighted everett function computed based harmonic components preisach model applied given flux waveform results validated measurements findings paper predicts total iron loss computing weighted everett function based harmonics present pwm waveform moreover formulates possibility utilizing classical preisach model predict iron losses pwm excitation research limitations implications approach still limited terms application high frequencies work may eventually lead toward accurate prediction iron loss pwm excitation electromagnetic machine design practical implications paper provides simple approach applying preisach model prediction iron losses pwm excitation proposed approach require additional experimental data beyond loops measured sinusoidal excitation originality value novel approach presented incorporate frequency dependence static inverse preisach model approach extends ability static preisach model compute total iron loss pwm excitation using weighted everett function
purpose present study seeks examine possibilities combined usage friction welding plastic forming recycling bar shaped waste materials design methodology approach waste materials reproduced using various manufacturing methods without melting economic values could increased economically reason using combination friction welding plastic forming chosen alternative recycling method upsetting chosen plastic forming method due ease application findings present study dimensional changes hardness variations heat affected zone haz variations torsion tensile strengths upsetting ratio specimens examined hardness values test material raised higher levels within haz local hardening maximum shear stress torsion tensile strengths specimens closely harmonious hardness values test material research limitations implications although observed general increasing upsetting ratio increased torsion tensile strengths experimental study must improved extended order obtain precise results practical implications concluded combined usage welded additional cold deformation considered alternative recycling method owing obtained positive results originality value paper helps individuals reutilize waste materials small lengths bars furthermore observed combination friction welding plastic forming produces savings material cost study
purpose purpose paper identify possible agents levers trigger development implementation work place health promotion programs whpps australian construction industry unlike large workplaces high risk workplaces programs rarely found construction sector design methodology approach qualitative interviews trades workers site based site construction managers used reveal perceptions impact whpps ill health poor health behaviors site activities view identifying leverage points introduce whpps construction findings unhealthy lifestyle behaviors seen impacting sites three main ways productivity broadly defined safety interpersonal relations results also reveal specific roles levers different actors supply chain clear desire collective industry based response identified health problems practical implications high levels chronic diseases construction industry means firms within sector must make concerted attempt change patterns behavior face significant long term health implications workforce reducing levels health longevity workforce mean work performance productivity participation likely decline originality value although construction workers recognized one workforces risk life limiting diseases type diabetes cardiovascular disease relatively little work investigated health well considerations construction workers study contributes investigating possible levers agents create healthier workplaces construction
purpose purpose paper investigate relationship pre training competencies apprentices productivity workplace design methodology approach analysis authors use firm level data apprentices oral writing competencies competencies basic mathematics information technology problem solving authors regress apprentices productivity school competencies include number firm apprentice specific control variables reducing authors data set firms one apprentice authors transform firm level data quasi individuallevel data findings main findings competencies equally related productivity problem solving competencies followed oral writing competencies show strongest relation productive potential apprentices competencies also positively weakly related apprentices productivity contrast higher levels basic mathematical competencies leave productivity levels largely unchanged differentiating occupational groups authors find positive relation competencies productivity predominantly exists commercial occupations rather industrial technical occupations practical implications results show better school competencies associated higher productivity apprentices turn lowers firms training costs policy perspective finding important implies improving apprentices competencies firms willingness participate apprenticeship system increased moreover results important training firms show competencies firms focus recruitment decision originality value paper studies first time relation pre training competencies productivity apprentices working place practical implication authors analysis could useful implement tools measuring problem solving oral writing competencies apprenticeship applicants process recruitment
purpose purpose paper investigate whole life costs non residential green rated building developments singapore derive useful information research practice industry stakeholders like building owners architects engineers quantity surveyors builders facility managers detailed information initial operating costs different types buildings able apply whole life costing existing new projects intention achieving value money well environmental sustainability developed index useful green policymakers building owners design methodology approach data collected building projects certified building construction authority bca singapore green mark scheme starting statistical analysis performed collected data generate information required build index well cost database paasche price index method used produce weighted composite index singapore non residential building sector findings results show classification whole life costs components two main groups development construction costs operating maintenance costs total cost significant items selected construction work categories comparing weights three non residential building types highest obtained industrial building followed institutional commercial buildings research limitations implications without data description research primarily dealt formulation proposed index designing appropriate methodology key ensure widespread acceptance use practical implications prospective users aware index provide information change absolute terms accurate reflecting actual level costs prices variable interest however good indicator relative change time level costs prices originality value expected method contributes additional information bca existing tender price index building operating costs well since proposed index measure change average whole life cycle costs buildings time
purpose purpose paper obtain understanding perception trust construction contracting parties research objectives identify factors construction projects impact trust identify trust affects factors construction project design methodology approach survey construction professionals working engineering news record top contractors conducted findings findings showed paying time competency reliability effective collaboration important factors affected contextual conditions trustworthiness factors perceived strengthen trust included face face communication electronic documents timely adequate responses requests information presence construction managers construction projects corrective changes orders neutral third parties perceived weaken trust trust perceived assist leadership team building communication information sharing originality value main contribution study discovery additional factors impact trust factors require trust identified previous researchers
purpose purpose paper present method computing voltage spikes endured insulation first coils high temperature degrees synchronous machines fed pwm inverters deliver fast fronted voltage pulses design methodology approach transient state following steep edge computed spice using global high frequency equivalent circuit motor winding equivalent circuit automatically built using proposed elementary coil model two inorganic degrees technologies compared first one uses round copper wire insulated thin ceramic layer second one made anodized aluminum strip findings winding made anodized aluminum strip higher turn turn capacitance yields better voltage distribution coils machine research limitations implications elementary coil equivalent circuit computed impedance measurements performed elementary coil another starting point could developed analysis determine parameters equivalent circuit would avoid need prototype coil machine design practical implications inorganic motors insulation layers poorer electrical characteristics compared standard organic ones therefore computation voltage spikes distribution along coils phase represents major issue design degrees machines originality value presented approach step toward design degrees degrees actuators fed pwm inverters based fast sic electronic switches
purpose purpose paper reveal dynamical behavior higher dimensional nonlinear wave searching multi wave solutions jimbo miwa equation design methodology approach authors apply bilinear form extended homoclinic test approach jimbo miwa equation findings paper using bilinear form extended homoclinic test approach authors obtain new cross kink multi soliton solutions dimensional jimbo miwa equation including periodic breathertype kink three soliton solutions cross kink four soliton solutions doubly periodic breather type soliton solutions doubly periodic breather type cross kink two soliton solutions shown extended homoclinic test approach help symbolic computation provides effective powerful mathematical tool solving higher dimensional nonlinear evolution equations mathematical physics research limitations implications research manifests structures solution higher dimensional nonlinear equations diversified complicated originality value methods used paper widely applied research spatial temporal characteristics nonlinear equations physics engineering technology methods also conducive people know objective laws grasp essential features development world
purpose purpose paper synthesise curable emulsion latex study characteristics various performance properties tackiness peel adhesion cohesive strength pressure sensitive adhesive psa application curing design methodology approach two component water based ultraviolet curable acrylate psas synthesised emulsion copolymerization synthesised emulsion samples characterised various performance properties tackiness peel adhesion cohesive strength psas tested curing findings thermal analysis showed effect methyl methacrylate content glass transition temperature emulsions significant effect tack effects varying concentration multifunctional monomer trimethylolpropane triacrylate tmpta exposure time properties curable psa also studied research limitations implications results associated curable water based psa certain advantages low voc fast curing rate scope research using radiations different intensities radiation systems electron beam curing practical implications practically water based psas already industrial use glass lamination silicon semiconductor dicing medical use band aids drug delivery systems dental applications cavity filling originality value water based curable psa synthesised emulsion polymerization good tackiness properties lower mma content observed lower concentration tmpta better performance properties tack peel strength also observed increasing tmpta concentration cohesive strength increased
purpose purpose paper uncover mechanisms influencing sustainability behavior changes following implementation teamwork design methodology approach realistic evaluation combined framework dcom based applied behavior analysis study sustainability behavior changes two half years initial implementation teamwork emergency department dcom framework used categorize mechanisms behavior change interventions bcis four categories direction competence opportunity motivation non participant observation interview data used findings teamwork behaviors sustained substantial fallback managerial activities combination complex context contributed reduced direction opportunity motivation reduced direction made staff members unclear work teams deterioration opportunity evident lack problem solving resources resulting accumulated barriers teamwork motivation terms management support feedback reduced practical implications implementation complex organizational changes complex healthcare contexts requires continuous adaption managerial activities well beyond initial implementation period originality value integrating dcom framework realistic evaluation study responds call theoretically based research behavioral mechanisms explain bcis interact context interaction influences sustainability
purpose slogan green embraced range organizations including businesses universities recent decades within higher education academic libraries key service unit parent institution important role play supporting mission authors seen many academic libraries strive green designing green library whether new build renovation paper aims discuss issues design methodology approach paper discusses chinese university hong kong cuhk library formulates develops implements green strategy strategy gradually reshaped services first authors consider concept sustainability affected services provided academic libraries green strategies practical feasible approach authors use cuhk library case study siting development green strategies context university approach sustainability wider cuhk community ultimately library overall strategic plan third section describes library implements green strategies different areas daily operation library offices services offered users planning library extension broader sustainability initiatives issues evaluation discussed authors conclude paper future plans findings academic libraries usa leadership energy environmental design certified originality value authors argue pursuing green building may strategic focus many academic libraries taking holistic approach sustainability practical measures academic libraries need formulate develop wider green strategies beyond green building green impacts attitudes towards environment also changes way academic libraries serve users community
purpose speculations whether environmental friendly buildings always healthy using lifecycle assessment lca methodology purpose paper investigate lifecycle relationship building sustainability environmental health impacts design methodology approach order achieve block classroom modelled aid revit software lifecycle global warming potential gwp human health impacts analysed using green building studio athena impact estimator tools sensitivity analyses block classrooms carried varying building materials energy use pattern original typology lca performed seven alternative typologies achieved variation building materials energy use patterns findings eight building typologies study shows direct relationship gwps human health impacts confirms sustainable building less tendency negative health effects building operatives occupants wider environment green building terms materials energy use pattern healthier building becomes research limitations implications human health impacts evaluated measuring amount particulate matter produced buildings environmental impact evaluated measuring global warming kgco potentials buildings throughout lifecycle study based impacts building materials energy use patterns entire lifecycle buildings materials used construction originality value study established positive relationship gwp building human health impacts thus arguments relating relationship building sustainability health laid rest paper
purpose paper one seven volume aims elaborate different approaches quality improvement education delineates methodology called lean education design methodology approach paper presents origins theoretical foundations core concepts case study demonstrating application education specifically dealing problem improving technology supports services instructional purposes school district system findings approach borrowed manufacturing lean aimed creating delivering greatest value clients customers education systems consuming fewest resources eliminating waste simultaneously method engages organization continuous problem solving learning making quality improvements plan check act cycles core concepts organize lean education approach continuous improvement respect people emiliani originality value theoretical treatments demonstration cases currently available commonly used models quality improvement fields might potential value improving education systems internationally large grade kindergarten education systems usa paper fills gap elucidating one promising approach paper also derives value permits comparison lean education method quality improvement approaches treated volume
purpose association subclinical hypothyroidism type diabetes complications previously documented reports however inconclusive mainly gathered chinese east asian populations study aimed determine prevalence subclinical hypothyroidism relationship diabetic nephropathy iranian individuals type diabetes drawn white middle eastern population increasing prevalence diabetes methods cross sectional study iranian participants type diabetes without history thyroid disorders included patients tsh miu normal classified subclinical hypothyroidism diabetic nephropathy diagnosed based abnormal urinary albumin protein measurements urinary albumin day urinary protein day multivariate logistic regression employed obtain relationship subclinical hypothyroidism diabetic nephropathy results found subclinical hypothyroidism diabetic nephropathy prevalent respectively among participants also found subclinical hypothyroidism independently associated higher rates diabetic nephropathy multivariable adjustment conclusions found prevalence subclinical hypothyroidism iranian diabetic population among highest rates reported date data supported independent association subclinical hypothyroidism diabetic nephropathy calling investigations evaluate longitudinal associations
purpose despite advances made systemic chemotherapy prognosis advanced triple negative breast cancer tnbc patients still poor identification key factors governing tnbc development considered imperative development novel effective therapeutic approaches previously reported microrna mir may act either tumor suppressor oncogene different types cancer aimed assessing biological role mirna tnbc methods first measured expression mir primary breast cancer tissues breast cancer derived cell lines using qrt pcr subsequently expression silencing experiments performed determine role mir tnbc cell proliferation colony formation migration invasion vitro vivo role mir tnbc growth metastasis determined mouse models bioinformatics analyses dual luciferase reporter assays western blot analyses rescue experiments performed identify mir target gene results found mir regulated primary breast cancer tissues derived cell lines particularly tnbc tissues cell lines also found exogenous mir expression augmented vitro tnbc cell proliferation colony formation migration invasion whereas mir regulation impaired features vivo found mir expression facilitated tnbc growth lung metastasis mechanistically mir found negatively regulate expression tripartite motif containing trim tnbc cells binding untranslated region mrna conformity results significant negative correlation mir expression trim protein expression noted primary tnbc tissues also found exogenous trim expression reversed proliferative invasive capacities tnbc cells conclusions data indicate mir acts oncogene tnbc mode action least partially ascribed regulation target trim suggest mir may serve promising therapeutic target tnbc
purpose idiopathic intracranial hypertension iih disorder increased intracranial pressure absence known causative factor sinus stenosis common patients stenting stenotic dural sinuses gained popularity treatment option since stenoses may contribute obstruction venous return thereby may contribute iih via increase venous sinus pressure evaluated safety efficacy endovascular treatment iih venous sinus stenosis methods fifty one patients iih underwent stenting median age years clinical manifestation headache patients visual obscurations papilledema present patients lumbar puncture documented elevated csf opening pressure one patient sinus stenoses observed patients results endovascular treatment successfully performed patients major complications encountered live threatening causing deterioration patient condition equivalent mrs improvement resolution papilledema observed patients reported improvement resolution headache follow angiographies performed patients median interval months demonstrated stent stenosis novo stenosis patients eight needed treatment conclusion venous sinus stenting safe effective alternative invasive treatments optic nerve sheath fenestration csf diversion patients iih majority patients persistent clinical benefit
purpose literature limited research changed meaning food eating eating experience treatment patients head neck cancer systematic review includes findings qualitative research synthesis gain deeper understanding influence experiences dysphagia dysgeusia oral mucositis xerostomia head neck cancer patients hnc suggests recommendations care practice method systematic review meta synthesis techniques adopted identify appraise synthesize relevant literature regarding experience nutritional symptoms hnc patients conducted according prisma guidelines several electronic databases pubmed cinahl scopus psycinfo cochrane library databases searched results systematic search yielded papers met inclusion criteria thematic account shared nutritional symptom experiences reported across studies highlighted presented eight major themes covering three key supportive care domains identified impact symptoms symptoms treatment symptoms working together affecting daily living activities physical changes symptoms food changes changing social networks support social life restrictions support peers nutritional concerns strategies coping strategies professional support conclusions dysphagia dysgeusia oral mucositis xerostomia negatively affected patients quality life throughout period treatment patients nutritional symptom experiences occur isolation therefore acknowledging patients eating difficulties challenges guarantee appropriate management support best manage symptoms timely manner
purpose proposed biological chemical substances intestine might play role occurrence deterioration perianal fistulas elimination unidentified factors lower gastrointestinal tract might offer new strategy management anal fistulas aim study evaluate clinical effects non crohn disease perianal fistula healing safety tolerability new medical device applies high purity high activity granular activated carbon locally rectum twice daily patients perianal fistulas without concomitant medication methods open single arm prospective study active treatment weeks optional follow week clinicaltrial gov identifier nct among patients chronic uncomplicated perianal fistulas scheduled surgery conducted results patients included patients showed complete fistula healing closed discharge palpation weeks seven patients corresponding enrolled patients remained remission weeks week statistically significant reduction discharge visual analog scale significant improvement patient perceived quality life category embarrassment trend toward improvement assessment categories conclusions treatment well tolerated patient acceptance high results support efficacy safety locally administered activated carbon treatment patients chronic uncomplicated perianal fistulas receiving medication fistula problems
purpose generally accepted dopamine agonists represent first line treatment patients prolactinoma patients become candidates surgical intervention contraindicated surgical indication cystic prolactinoma remains controversial study performed investigate significance surgery cystic prolactinoma methods total patients underwent transsphenoidal resection prolactinoma february may reviewed five consecutive patients cystic prolactinoma included study surgical strategy cystic prolactinoma categorized follows first purpose surgical resection normalization prolactin level aggressive resection performed second volume reduction essential relieve visual symptoms headache internal decompression performed followed therapy clinical outcomes analyzed accordingly results cystic prolactinoma resected via transsphenoidal approach without complications symptoms including visual impairment hypogonadal activity finally relieved combined medication conclusions surgery cystic prolactinoma could better option transsphenoidal surgery relatively safe remove cystic prolactinoma additionally normalize prolactine level achieve adequate rapid decompression optic chiasm risk transsphenoidal surgery highly dependent skill surgeon treatment decision cystic prolactinoma needs individualized patient
purpose many cancer survivors report experiencing somatic symptoms well elevated stress theoretical models suggested physical symptoms generate subjective stress via fears recurrence progression date indirect effect established empirically study aimed provide preliminary evidence whether fear recurrence progression intermediary somatic symptom severity perceived stress among heterogeneous cancer survivors methods adult cancer survivors median years since diagnosis male presenting hospital survivorship clinic completed measures assessing somatic symptom severity patient health questionnaire phq perceived stress four item perceived stress scale pss fear recurrence progression assessment survivor concerns asc interrelatedness among variables assessed using pearson correlations indirect effects modeled using iteration bootstrapping results survivors endorsed range somatic symptom severity minimal low medium high somatic symptoms perceived stress fear recurrence progression significantly positively correlated controlling time since diagnosis significant indirect effect somatic symptom severity stress via fear recurrence progression model accounted one third variance perceived stress conclusions survivors greater somatic symptoms tended report higher levels stress due part elevated fears recurrence progression findings support concerns recurrence progression mechanism underlying stress states cancer survivors efforts assist survivors stress management teach strategies managing cancer related uncertainties stemming somatic symptoms
purpose review cancer incidence increases worldwide thus patients suffer cancer pain cancer pain severely affects quality life decrease pain high priority every clinician last decade attention cancer pain treatment increased new pharmacological based treatment options became available gave reason hypothesize decrease pain prevalence cancer patients last decade recent findings despite increased attention cancer pain pain prevalence cancer patients significantly changed last decade compared four decades absence change might comorbidities cancer patients also undertreatment pain lack knowledge pain measurement factors underlying absence change use incorrect coanalgesics case treatment neuropathic pain well present absence potent analgesics little side effects summary consistent screening pain cancer patients consequent correct treatment pain might result impressive decrease cancer pain reduction pain new pharmacological analgesics need developed
purpose review currently ability accurately predict patient risk developing severe gastrointestinal toxicity cancer treatment limited risk stratification continues rely traditional patient related treatment related factors including age ethnicity sex comorbidities genetics agent dose schedule although informative crude measures continue underestimate toxicity risk hence alternative methods risk prediction must investigated given increasing focus gut microbiome driving disease review provide overview current literature proposing gut microbiome novel predictive tool treatment induced gastrointestinal toxicity recent findings predictive gut microbial phenotypes identified gastrointestinal toxicity induced radiation checkpoint blocker ipilimumab study employed slightly different methods gut microbiome assessment however cases separation toxic versus nontoxic patients achieved studies investigated chemotherapy induced gastrointestinal toxicity summary gut microbiome offers exciting new method risk stratification gastrointestinal toxicity would enable identification high risk patients prior treatment enabling tailored treatment regimens based personalized risk assessment proactive provision supportive care measures based plasticity gut microbiome methods risk mitigation may investigated
purpose review despite limited understanding exact mechanism corticosteroids commonly employed pain control patients bone metastases aim review evaluate efficacy corticosteroid mediated pain control patients bone metastases associated solid cancers recent findings literature search conducted using ovid medline embase databases july studies involving patients bone metastases receiving corticosteroids primary means pain control included screening data extraction conducted paired reviewers consensus established discussion third adjudicator total studies included rates pain relief achieved corticosteroid use varied generally reflected moderate pain control corticosteroid use significantly reduced incidence pain flare alongside radiotherapy reportedly almost half baseline pain severity adverse events documented consistently across studies though grade two three hyperglycemia noted approximately patients studies summary recent evidence suggests short term corticosteroid use may provide moderate pain pain flare control radiotherapy patients bone metastases risk developing adverse effects carefully considered prior therapy initiation case case basis
purpose review dysfunctional voiding defined habitual contraction urethral sphincter voiding children dysfunctional voiding remain challenge approach management lut dysfunction varies widely among programs providers role pharmacotherapy ill defined recent findings animated biofeedback current treatment modality choice children responsive standard urotherapy comprehensive biofeedback programs incorporate continued elimination education voiding diaries home exercises high success rates recent studies suggest botulinum toxin results persistent satisfactory results select children refractory dysfunctional voiding summary conservative measures including aggressive bowel regimen timed voiding mainstays treatment motivated children persistent symptoms often respond favorably escalating urotherapy biofeedback pharmacotherapy plays ancillary role management dysfunctional voiding
purpose review echocardiography mainstay diagnostic evaluation constrictive pericarditis restrictive cardiomyopathy rcm single echocardiographic parameter sufficiently robust accurately distinguish two conditions present review summarizes recent advances echocardiography promise improve diagnostic performance purpose role imaging modalities cardiac computed tomography magnetic resonance imaging invasive hemodynamic assessment overall diagnostic approach also discussed briefly recent findings recent study demonstrated improved diagnostic accuracy echocardiography integration multiple conventional echocardiographic parameters step wise algorithm concurrently studies using speckle tracking echocardiography revealed distinct disparate patterns myocardial mechanical abnormalities rcm ability distinguish two conditions incorporation machine learning algorithms echocardiography workflow permits easy integration wealth diagnostic data available promises enhance diagnostic accuracy echocardiography summary new imaging algorithms continuously evolved permit accurate distinction rcm research needed validate accuracy newer algorithms define place overall diagnostic approach purpose
purpose review exacerbations bronchiectasis major impact quality life healthcare costs long term risk complications preventing exacerbations one major goals treatment bronchiectasis increasingly recognized impact bronchiectasis exacerbations daily clinical practice also increasing recent findings preventing bronchiectasis exacerbations dependent appropriate risk assessment identifying patients highest risk rationally target preventive therapies inhaled oral antibiotic treatments target chronic bacterial infection one major risk factors exacerbation although data weak airway clearance important part long term management including patients frequent exacerbations anti inflammatory therapies inhaled corticosteroids currently major role outside comorbid chronic obstructive pulmonary disease asthma studies required summary treatment acute exacerbations involves prompt administration antibiotic therapy usually days oral severe exacerbations intravenous antibiotics role corticosteroids established little data optimal management approach acute exacerbations home intravenous therapy reduce healthcare costs improve patient satisfaction care number large randomized controlled trials currently enrolling recently completed raising possibility treatment paradigm may change near future
purpose review multiple clinical epidemiological studies demonstrate links allergic sensitization virus induced atopic disease exacerbations review summarizes recent findings regarding allergen viral host cellular mechanisms relevant observations recent findings recent studies focused molecular pathways genetic influences involved allergen mediated inhibition innate antiviral immune responses multiple tissue cell types atopic individuals across atopy spectrum exhibit deficient interferon responses variety virus infections impairment barrier function viral rna dna recognition intracellular sensing molecules dysregulation signaling components broadly affected allergic sensitization finally genetic predisposition numerous nucleotide polymorphisms also impacts immune pathways potentially contributes virus associated atopic disease pathogenesis summary allergen virus interactions setting atopy involve complex tissue cellular mechanisms future studies defining pathways underlying interactions could uncover potential therapeutic targets available data suggest therapies tailored restore specific components antiviral responses likely lead improved clinical outcomes allergic disease
purpose review patients type diabetes mellitus tdm increased risk systemic atherosclerosis advanced coronary artery disease cad herein review clinical trials comparing surgical percutaneous revascularization context unique pathophysiology patient population seek answer question optimal strategy revascularization recent findings early studies showed signal towards benefit surgical revascularization percutaneous revascularization group paucity randomized clinical trials rct directly support finding future revascularization evaluation patients diabetes mellitus optimal management multivessel disease freedom large scale international rct undertaken established benefit coronary artery bypass grafting cabg percutaneous coronary intervention pci terms mortality myocardial infarction repeat revascularization cabg inferior pci regards stroke quality life cost effectiveness also demonstrated long term benefit surgery summary decision choice mode revascularization patients tdmand advanced cad depends upon multitude factors including coronary anatomy comorbidities patient surgical risk factors influence recommendation cardiovascular team result balanced presentation short long term risks benefits either mode revascularization patient family
purpose review post traumatic headache pth common headache type traumatic brain injury tbi fda approved medications pth unknown medications affect brain ability recover tbi thus sought examine biopsychosocial factors influence pth non pharmacologic treatments studied headache treatment also sought determine literature examining whether non pharmacologic treatments influence biopsychosocial factors non pharmacologic treatments assessed included cognitive behavioral therapy cbt biofeedback progressive muscle relaxation therapy pmr acupuncture physical therapy recent findings factors associated prognosis pth may include following severity tbi stress post traumatic stress disorder psychiatric comorbidities sociocultural psychosocial factors litigation base rate mis attribution expectation etiology chronic pain high quality studies non pharmacologic treatments pth thermal emg biofeedback appear examined followed cbt studies secondary outcomes examining psychosocial factors related pth summary behavioral studies involved multi modality intervention limiting ability assess individual non pharmacologic interventions sought study randomized clinical trials evaluating efficacy non pharmacologic interventions therefore future research considers noted biopsychosocial factors needed field determine interventions reduce pth
purpose review pre procedural imaging essential successful planning performance several cardiac interventions cardiac computed tomography non invasive imagingmodality capable providing precise information required different coronary non coronary interventions role cardiac guidance different cardiac interventions described review recent findings contrast enhanced computed tomography imaging increasingly used guiding transcatheter cardiac interventions anatomical functional information provided helps successful planning performance several cardiac interventions summary last decade continuous growth interventional cardiology associated widespread acknowledgment particularly useful pre interventional imaging increasing implementation clinical routine
purpose review aim study characterize diagnose evaluate treat severe childhood asthma recent findings understanding occurrence physiologic clinical presentations childhood severe asthma treatment response may predicted biomarkers patient response highly variable summary onset severe asthma occurs early primarily predicted severity viral infection coexistence atopic state
purpose review inflammatory makeup severe asthma heterogeneous identification predominant cellular endotype via biomarkers aid selection advanced therapies review clinically focused use biomarkers help select biologic agents bronchial thermoplasty recent findings several biomarkers exist detection eosinophilic disease however best biomarker clinical practice debatable depending upon local resources currently three federal drug agency approved biologic agents omalizumab mepolizumab reslizumab treat severe asthma frequent exacerbations despite standard medical therapy several others either clinical trials development phase treatment eosinophilic asthma date agents targeting neutrophilic inflammation largely unsuccessful bronchial thermoplasty emerged option treatment severe asthma summary appropriate selection patients use eosinophilic biomarkers led significant reductions exacerbations use mab therapy bronchial thermoplasty also shown reductions asthma exacerbations improved quality life however unclear patients may respond best intervention
purpose review prevalence cardiovascular disease differs among ethnic groups along geographic boundaries present projected increase mortality cardiovascular disease occurs sub saharan african chinese southeast asian populations ethnic disparities prevalence cardiovascular disease coincide quantitative qualitative differences risk factors cardiovascular disease high plasma cholesterol one important preventable causes ischemic heart disease recent findings current review summarizes recent evidence ethnic differences ischemic heart disease correlates genetic acquired differences plasma lipid lipoprotein levels nature ethnic differences plasma lipid levels apolipoprotein lipoprotein outlined effects lipid lowering therapy future efforts challenges regarding implementation discussed summary ethnic differences hdl cholesterol hdl triglyceride levels may impact ethnic differences cardiovascular disease result higher residual risk lipid lowering therapy efforts made stimulate use statins high income low income countries study effects individuals different ethnic backgrounds
purpose review purpose study review literature perinatal intimate partner violence focusing recent knowledge guide mental health professionals best approaches identify treat women exposed perinatal intimate partner violence recent findings risk factors broadened individual victim perpetrator factors include relationship community societal factors interact together better information available identify document treat women exposed violence around time conception pregnancy postpartum period summary recent information helps psychiatrists mental health professionals assist women exposed violence related perinatal period however research needed provide improved evidence optimal interventions better patient outcomes
purpose review purpose study review recent randomised controlled trials coronary computed tomography angiography ccta patients stable coronary artery disease recent findings initial results subsequent papers scot heart scottish computed tomography heart promise prospective multicentre imaging study evaluation chest pain trials shown ccta safe appropriate addition standard care alternative functional testing scot heart study showed ccta changes diagnoses improves diagnostic certainty changes management leads appropriate use invasive coronary angiography reduces fatal nonfatal myocardial infarction meta analysis four randomised controlled trials showed ccta leads major reduction myocardial infarction patients stable chest pain summary ccta established technique assessment coronary artery disease recent test treat randomised controlled trials shown ccta guided changes management improve clinical outcomes
purpose review review focused associations temperament dimensions clinical features different anxiety disorders likewise obsessive compulsive disorder clinical samples adults literature search conducted medline psycinfo databases covering years systematic review grading level evidence association temperament dimension scores clinical features disorder performed recent findings twenty papers reporting different studies included five papers focused panic disorder five social anxiety disorder sad three post traumatic stress disorder ptsd one generalized anxiety disorder gad three obsessive compulsive disorder ocd additional three papers several anxiety disorders summary review consolidates finding trait anxiety especially assessed cloninger model fivefactor model phenomenon common anxiety disorders ocd follow studies including large samples needed differentiate dimensional profiles trait anxiety specific disorders
purpose review rising suicide rate usa reversed without improved risk assessment prevention practices date best method clinicians assess patient risk suicide screening past suicide attempts patient family however neuroimaging genomic biochemical studies generated body findings allow description initial heuristic biological model suicidal behavior may predictive value recent findings review studies past years examining potential biological predictors suicide attempt behavior divide findings two major categories structural functional brain imaging findings biochemical genomic findings encompassing several systems including major neurotransmitters serotonin catecholamines gaba glutamate hypothalamic pituitary adrenal hpa axis inflammasome lipids neuroplasticity summary biomarkers appear promising assessing suicide risk clinical settings include indices serotonergic function inflammation neuronal plasticity lipids
purpose review review examines current status catheter based repair replacement mitral valve disease focus native primary secondary mitral valve regurgitation recent findings transcatheter mitral valve repair mitraclip performed procedures worldwide significantly advanced field transcatheter therapy mitral valve regurgitation transcatheter mitral valve replacement remains early stages development mainly due complex anatomy physiology mitral valve early feasibility studies high risk patients show promising procedural success yet adverse events require study summary transcatheter therapies mitral valve disease next endeavor pioneers percutaneous structural heart disease interventions early results encouraging also show rigorous study needed determine efficacy safety
purpose review review provides overview current state drug therapy obesity focus four new drug therapies lorcaserin phentermine topiramate naltrexone bupropion liraglutide approved food drug administration fda long term management obesity since topics discussed paper include rationale pharmacotherapy history antiobesity drugs efficacy safety data randomized controlled trials implications clinical practice recent findings weight loss achieved currently approved drugs ranges approximately beyond weight loss lifestyle counseling alone year response attrition rates clinical trials indicate benefits pharmacotherapy range substantial patients modest others benefits others still summary decisions regarding selection suitable drug available pharmacotherapy options duration treatment based expected observed benefit risk balance tailored needs individual patient using principles shared decision making
purpose review review provides update summary recent neuropsychological findings epilepsy focusing three major clinical topics among many developments field critically outline current state regard cognition new onset epilepsies social cognition epilepsy long term outcome epilepsy surgery cognitive outcomes superselective surgical procedures recent findings current studies indicate neuropsychological impairments prevalent already onset epilepsy even social cognition emotion recognition theory mind impaired different epilepsy populations long term outcome epilepsy surgery mostly characterized stable even improved cognitive status superselective epilepsy surgeries associated promising neuropsychological outcome summary high prevalence cognitive deficits around epilepsy onset challenges assumption epilepsy major cause cognitive problems calls early neuropsychological diagnostics social cognition seems relevant domain yet routinely considered epilepsy cognitive long term outcome epilepsy surgery mostly positive stereotactic thermocoagulation gamma knife surgery appear cognitively safe procedures
purpose review thoracic radiation therapy effective treatment several malignancies hodgkin lymphoma breast cancer years however incidence cardiovascular events increased patients notably younger survivors traditional risk factors review summarizes pathology incidence clinical presentation management cardiac events radiation therapy recent findings mediastinal radiation therapy accelerates atherosclerosis process resulting early onset coronary artery disease valvular disease due radiation therapy typically affects left sided valves aortic regurgitation common rarely may lead aortic stenosis requiring surgical interventions pericardial involvement includes acute chronic pericardial disease pericardial effusion new studies investigating prevalence pathogenesis autonomic dysfunction cancer survivors undergone mediastinal neck radiation summary radiation therapy causes vascular endothelial dysfunction resulting clinical cardiovascular events manifesting many years completion therapy remains little guidance regarding screening therapies prevent cardiovascular events population
purpose review transcatheter aortic valve replacement tavr developed important alternative surgical aortic valve replacement savr patients severe aortic stenosis adjuvant antithrombotic therapies commonly used tavr decrease risk valve thrombosis thromboembolic cerebrovascular events cves consequently increase risk bleeding article reviews past current clinical data regarding adjuvant antithrombotic therapies tavr recent findings cerebrovascular bleeding events tavr associated substantial morbidity mortality bivalirudin direct thrombin inhibitor shown safe alternative unfractionated heparin ufh procedural anticoagulation tavr however sparse evidence exists guide use antiplatelet anticoagulant therapies patients tavr multiple studies comparing different antithrombotic regimens post tavr setting currently underway summary current guidelines recommend intra procedural anticoagulation ufh tavr dual antiplatelet therapy dapt tavr need better understand role adjuvant antithrombotic therapies tavr results ongoing studies needed develop evidence based guidance use adjuvant antithrombotic therapies tavr
purpose review trouble falling staying asleep poor sleep quality short long sleep duration gaining attention potential risk factors cognitive decline dementia including alzheimer disease sleep disordered breathing also linked outcomes review recent observational experimental studies investigating effect poor sleep cognitive outcomes alzheimer disease discuss possible mechanisms recent findings observational studies self report objective sleep measures wrist actigraphy polysomnography support links disturbed sleep cognitive decline several recently published studies demonstrate associations sleep variables measures alzheimer disease pathology including cerebrospinal fluid measures beta pet measures beta deposition addition experimental studies suggest sleep loss alters cerebrospinal fluid beta dynamics decrements slow wave sleep may decrease clearance beta brain hypoxemia characteristic sleep disordered breathing increases beta production summary findings indicate poor sleep risk factor cognitive decline alzheimer disease although mechanisms underlying associations yet clear healthy sleep appears play important role maintaining brain health age may play key role alzheimer disease prevention
purpose review venous thromboembolism frequent chronic myeloproliferative neoplasms mpn current strategy management includes cytoreductive therapy antithrombotic prophylaxis many issues remain uncertain review risk factors prevention recurrences discussed recent findings around one third patients polycythemia vera essential thrombocythemia experience major thrombosis diagnosis follow according european leukemia net guidelines patients must included high risk group thrombotic recurrence treated cytoreduction antiplatelet anticoagulant drugs presence arterial venous thrombosis respectively despite treatment annual incidence recurrence first venous thrombosis varies vitamin antagonists doubled discontinuation highest incidence recurrence occurs cerebral hepatic vein thrombosis per years respectively occurrence major bleeding vitamin antagonists similar non mpn population accounts rate per years summary venous thrombosis incidence recurrence mpn remains elevated suggested need review current recommendations primary secondary prophylaxis
purpose review provide date perspective potential use ldl particle number size complementary risk factors predict manage cardiovascular disease cvd risk clinical realm recent findings studies show significant proportion population discordant ldl particle number cholesterol indices non hdl cholesterol hdl data also show risk prediction may improved using information ldl particle number patients discordant particle number cholesterol data yet current cvd guidelines conclude ldl particle number superior cholesterol indices including non hdl concentrations predicting cvd risk ldl particle size hand independently associated cvd risk adjustment risk factors ldl cholesterol triglycerides hdl routine use information pertaining particle size determine manage patients risk yet justified summary additional studies required settle debate cholesterol indices ldl particle number best predictor cvd risk measures integrated clinical practice
purpose reviewmyeloproliferative neoplasms mpn conditions great interest identification molecular basis entering new small molecules clinical practice aim review report role mutations diagnosis prognosis prediction response jak inhibitors mpn recent findingsnew mutations calr gene discovered patients without jak mpl mutations included world health organization classification system role asxl srsf together driver mutations emerging prognostication myelofibrosis summarya wide mutational analysis mpn helps define diagnosis prognosis future clinical trials based robust valuation mutations guide treatment decision making towards precision medicine
purpose reviewthere ample growing evidence obesity increases risk asthma morbidity asthma review recent clinical evidence supporting causal link obesity asthma mechanisms may lead obese asthma recent findingsalthough children obesity asthma simply occur obese asthma increased asthma severity lower quality life reduced medication response underlying mechanistic pathways may include anatomical changes airways obstruction dysanapsis systemic inflammation production adipokines impaired glucose insulin metabolism altered nutrient levels genetic epigenetic changes alterations airway gut microbiome small studies shown weight loss interventions may lead improvements asthma outcomes thus far research therapeutic interventions children limited summaryobesity increases risk asthma worsens asthma severity control via multiple mechanisms obese asthma complex multifactorial phenotype children obesity complications must managed part treatment asthma obese children
purpose study elderly peoples values preferences end life care yet known details aim present study investigate end life wishes decision making among japanese elderly people required home care services study designed qualitative research strategies using face face interview data recorded nursing care records focus advance care planning design methods total elderly people males females home care support offices hyogo prefecture participated results implications finally extracted following themes anxiety future abandonment control clinging current daily life precarious mutual support delegating decision making elderly people living home generally feel anxious fearful future seemed try avoid thinking seriously possible complications life also tend leave end life decision someone else decisions tend change advance age condition deteriorates findings suggest medical professionals care managers always support patients decisions allowing views informal caregivers elderly people rely decision making elsevier rights reserved
purpose study adults hiv infection living old age critical investigate positive constructs resilience mastery determine factors associated psychological well examine hiv related factors adverse conditions psychosocial characteristics associated resilience ability bounce back mastery sense self efficacy design methods analyzed data longitudinal study aging pride national health aging sexuality gender study nhas focusing subsample gay bisexual older men multivariate linear regression used identify factors contributed detracted resilience mastery sample recruited sites across united states results resilience mastery independently associated psychological health related quality life multivariate analysis adjusting demographic characteristics previous diagnosis depression negatively associated resilience time since hiv diagnosis positively associated mastery whereas victimization negatively associated mastery social support community engagement positively associated resilience mastery implications individual structural environmental characteristics contributed resilience mastery findings used develop interventions incorporating increased understanding factors associated resilience mastery
purpose oncology practice guidelines recommend incorporating weight management efforts throughout survivorship care however oncologists raise concerns implementing weight management counseling without damaging patient provider relationships study explores cancer survivors receptivity weight management counseling examines whether views counseling effectiveness associated individual characteristics including health related perceptions psychological distress methods patients presenting nci comprehensive cancer center gynecologic oncology ambulatory clinic asked complete survey assessing health weight history health perceptions psychological distress provider preferences weight management counseling perceptions results two hundred forty four gynecologic cancer patients endometrial ovarian cervical completed surveys mean participant bmi overweight obese survivors agreed oncologists discuss healthy eating exercise weight loss reported receiving weight management counseling oncologist reported likely attempt weight loss counseled physician reported counseling would offensive regression results indicated viewing weight management counseling effective associated fewer depressive symptoms greater enjoyment physical activity viewing counseling unfavorably associated history attempting multiple weight loss strategies overall view healthy behaviors less beneficial conclusions gynecologic cancer survivors want weight management counseling oncologists believe counseling effective rather deleterious yet obesity remains inadequately addressed results study highlight important topics incorporated weight management counseling
purpose patients rheumatoid arthritis osteoarthritis may require revision total knee replacement studies compared post operative complications results risk revision patients material methods forty five patients undergone revision tka selected matched patients revision period results use revision posterostabilized implant osteoarthritis compared results use inflammatory arthritis mean follow ten years range years determined differences comorbidities risk peri operative adverse events functional radiological results risk subsequent revision patients suffering versus results higher comorbidities post operative days adverse events mortality average ten years patients mean overall changes function scores greater revision group compared revision group taking steroids cox regression methotrexate tnf alpha blockers cox regression significant factors radiolucent lines loosening average ten years followup patients undergoing revision tkas likely revision among patients patients undergoing revision department patients conclusions similar results knee observed two forms arthritis spite fact initial local joint status general health status worse inflammatory rheumatoid arthritis degenerative osteoarthritis however complications frequent
purpose postpartum depression ppd affects nearly mothers delivery many serious results although many factors associated ppd etiology pathophysiology ppd known completely relationship serum serotonin concentration depression well known enough data regarding serum change leptin adiponectin aims study research level serum serotonin leptin adiponectin concentrations women ppd materials methods controlled trial conducted three centers two hundred forty four women evaluated postpartum day edinburgh postnatal depression scale epdd venous blood samples collected serotonin leptin adiponectin levels studied using human enzyme linked immunosorbent assay mann whitney test used comparison serum levels serotonin leptin adiponectin women ppd without value considered significant results ppd detected postpartum women mean serum serotonin level significantly lower group ppd mean serum adiponectin level higher mean serum leptin level different conclusions serum adiponectin leptin levels high women ppd could play important role pathophysiology ppd elevation serum levels also may play antidepressant role ppd especially early postpartum period
purpose aim study compare differences current orthopaedic trauma training programs across europe methods questionnaire sent forte federation orthopaedic trainees europe representatives different european countries responded questionnaire included demographic information information concerning structure training programs including duration selection mandatory training requirements results number trainees per specialist varied countries ratio residency generally five six years countries half countries selection interview based nearly countries utilized logbook participating countries final examination assessing components training found one country united kingdom mandatory minimum requirements courses surgical procedures research leadership nearly participating countries one none four components mandatory training requirement conclusions many similarities training programs important differences remain overall requirements final qualification main limitation study unable get data european countries forte continue serve forum sharing best practices ultimate goal improving harmonizing level orthopaedic training across europe future studies aim include details training programs well include data countries
purpose goal rct examine efficacy safety web based program improve cardiovascular bone health outcomes among brca breast cancer survivors underwent prophylactic oophorectomy thus experienced premature surgical menopause methods month commercially available web based lifestyle modification program precision nutrition coaching utilized cardiovascular fitness dietary intake leisure time activity body composition bone mineral density bone structure muscle strength assessed results average adherence program components women intervention group maintained cardiovascular fitness level months control group significantly decreased fitness capacity significant difference groups percent change whole body bone area control intervention also observed decreased bmi fat mass intervention group due significant concomitant decreases caloric intake increases caloric expenditure control group demonstrated decreased caloric intake decreased lean tissue mass conclusions population high risk detrimental cardiovascular bone outcomes commercially available lifestyle intervention program mitigated decline cardiovascular health improved bone health decreased weight fat loss
purpose study aimed prospectively investigate association isolated functional lower extremity muscle strength risk noncontact anterior cruciate ligament acl injury norwegian female elite handball football players methods premier league players participated strength testing prospectively followed acl injury risk baseline recorded player demographics playing acl injury history measured peak concentric isokinetic quadriceps hamstring torques degrees hamstring quadriceps ratio isometric hip abduction strength one repetition maximum seated leg press followed predefined statistical protocol generated five separate logistic regression models one proposed strength risk factors adjusted confounding factors new acl injury outcome using leg unit analysis results total players age height body mass suffered noncontact acl injury baseline testing sustaining new injury among acl injury history confidence interval none five strength variables selected statistically associated increased risk acl rupture adjusted sport dominant leg acl injury history height conclusion peak lower extremity strength associated increased acl injury risk among female elite handball football players hence peak strength measured present study used screen elite female athletes predict injury risk
purpose assess impact vertigo health related quality life hrqol children adolescents assess impact hrqol varies age group gender type vertigo diagnoses methods retrospective analysis performed clinical hrqol data children adolescents referred german center vertigo balance disorders male female age range years using kidscreen questionnaire scale means scores confidence intervals study norm sample compared nonparametric kruskal wallis statistics differences diagnostic groups assessed assess gender age specific impact vertigo quality life wilcoxon signed rank test used results means physical well psychological well autonomy scale general hrqol index patients considerably lower means norm sample physical well seemed affected vertigo reduction hrqol related gender vertigo types seemed higher children suffering vertigo aged years children aged years conclusion first data demonstrate impaired hrqol children chronic vertigo
purpose characterize epidemiology costs associated spinal cord injury without radiographic abnormality sciwora based patient age methods analysis data complied healthcare utilization project kid database hcup kid represents nationwide database pediatric admissions performed initial search identified children diagnosed sciwora based international classification diseases edition icd codes data patients aged years included analysis associated codes searched identify cause injury pertinent epidemiologic data collected database including age gender racial group injury level pattern determined associated icd codes associated injuries hospital data included length stay hospital mortality total hospital charges primary payer data compiled stratified based patient age three groups group age years group age years group age years data compared using student test chi squared analyses results total patients identified met inclusion criteria slight predominance females among youngest patients significant dominance males oldest group common race among patients studied white followed hispanic black asian pacific islander native american overall common cause injury sports injuries responsible injuries followed motor vehicle collisions mechanisms injury significantly varied based age group motor vehicle collisions common cause youngest two age groups sports injuries common oldest age group common location injured cervical spine upper cervical spine commonly injured particularly younger age groups additional injuries found patients common among younger patients head trauma common associated injury age groups highest rate found youngest age groups average hospital stay patients days longer stays seen younger age groups hospital mortality uncommon among patients occurred patients hospital charges highest younger age groups average charge youngest age group decreasing group common payer public insurance medicaid youngest age group private insurance groups conclusions sciwora uncommon potentially devastating injury children many pediatric injuries injury heterogeneous children differing ages analysis nationwide series children injuries identified significant differences injury location causes injury associated injuries hospital charges associated diagnosis
purpose determine characteristics eyes late bag dislocation intraocular lens iol pars plana vitrectomy ppv methods fourteen eyes patients dislocated iol ppv studied retrospectively data collected medical charts included age sex history eye diseases axial length interval ppv time iol dislocation surgical procedures used ppv also recorded results seven eyes undergone ppv rhegmatogenous retinal detachment eyes proliferative diabetic retinopathy eye retinal vein occlusion average interval ppv diagnosis dislocated iol years range years eyes peripheral vitreous thoroughly removed scleral depression ppv conclusions iol dislocation likely caused damage zonular fibers peripheral vitrectomy scleral depression
purpose evaluate effect half dose verteporfin photodynamic therapy hpdt physiology macula determined focal macular electroretinograms fmergs eyes chronic central serous chorioretinopathy csc methods fourteen eyes patients chronic csc treated hpdt best corrected visual acuity bcva measured optical coherence tomography oct fmergs performed baseline days months hpdt results subreitnal fluid resolved eyes hpdt amplitude wave months significantly increased times baseline amplitude wave also increased significantly implicit time wave significantly reduced months wave months amplitudes oscillatory potentials change significantly month follow period conclusions hpdt led improvement fmergs least months without transient depression fmergs eyes chronic csc hpdt used safely treat eyes csc
purpose traumatic injury leading cause work disability receiving compensation post injury consistently found associated poorer return work study investigated whether relationship receiving compensation return work associated elevated symptoms psychological distress anxiety depression posttraumatic stress disorder perceived injustice methods injured persons employed time injury recruited victorian state trauma registry victorian orthopaedic trauma outcomes registry participants completed hospital anxiety depression scale posttraumatic stress disorder checklist injustice experience questionnaire appraisals pain work status months following traumatic injury results greater financial worry indicators actual perceived injustice consulting lawyer attributing fault another perceived injustice sustaining compensable injury trauma severity days hospital intensive care discharge rehabilitation distress symptoms anxiety depression ptsd led twofold sevenfold increase risk failing return work anxiety post traumatic stress perceived injustice elevated following compensable injury compared non compensable injury perceived injustice uniquely mediated association compensation return work adjusting age injury trauma severity length hospital admission intensive discharge location pain severity conclusions given perceived injustice associated poor return work compensable injury recommend greater attention given appropriately addressing psychological distress perceived injustice injured workers facilitate smoother transition return work
purpose unintentional injuries occur frequently many accident survivors suffer temporary permanent disabilities although accident victims recover quickly significant fraction shows complicated recovery process accounts majority disability costs thus early identification vulnerable persons may beneficial compensation schemes government bodies well worker present work health questionnaire whq screening tool already implemented case management process swiss accident insurance fund suva moreover demonstrate prognostic value identifying workers risk complicated recovery process methods total injured workers answered whq within first months accident minor moderate accidental injuries severely injured workers excluded analyses anonymized individual level data extracted insurance databases examined construct validity factorial analyses prognostic validity hierarchical multiple regression analyses days work disability evaluated well job satisfaction months post injury subsample injured workers results factor analyses supported five underlying factors job design work support job strain somatic condition pain anxiety worries subscales moderately correlated thus indicating different subscales measured different aspects work health related risk factors injured workers item analysis reliability analysis showed accurate psychometric properties subscale predictive least one evaluated outcomes months post injury conclusion whq shows good psychometric qualities high clinical utility identify injured persons multiple psychosocial risk factors thus questionnaire appears suitable exploring different rehabilitation needs among minor moderate injured workers
purpose aimed evaluate autonomic nervous system activity children overactive bladder oab syndrome methods included study children overactive bladder healthy controls autonomic tests performed participants including heart rate interval variation rriv heart rate response valsalva maneuver sympathetic skin response ssr results mean valsalva rates overactive bladder control groups respectively statistically significant difference conclusions study demonstrated parasympathetic hyperactivity children oab results suggesting dysfunction autonomic nervous systems wiley periodicals inc
purpose investigated whether perfectionism body image attachment style self esteem predictors orthorexia nervosa methods cohort participants completed self administered online questionnaire consisting five measures orto multidimensional perfectionism scale mps multidimensional body self relations questionnaire appearance scale mbsrq relationship scales questionnaire rsq rosenberg self esteem scale rses results correlation analysis revealed higher orthorexic tendencies significantly correlated higher scores perfectionism self oriented others oriented socially prescribed appearance orientation overweight preoccupation self classified weight fearful dismissing attachment styles higher orthorexic tendencies also correlated lower scores body areas satisfaction secure attachment style significant correlation orthorexia nervosa self esteem multiple linear regression analysis revealed overweight preoccupation appearance orientation presence eating disorder history significant predictors orthorexia nervosa history eating disorder strongest predictor conclusions orthorexia nervosa shares similarities anorexia nervosa bulimia nervosa regards perfectionism body image attitudes attachment style addition history eating disorder strongly predicts orthorexia nervosa findings suggest disorders might spectrum disordered eating
purpose development implementation certificate program pharmacy residents described summary university north carolina unc medical center met call increased efforts area pharmacy residency leadership training design implementation evaluation leadership certificate program purpose unc certificate program develop leaders serve others improve communities advance profession program designed foster self awareness social awareness altruism provide transferable individualized leadership experiences enrich residency components integration leadership development opportunities create role models departmental leadership team preceptors residents implemented certificate program integrating program components existing pharmacy residency infrastructure certificate program includes required flexible components allow residents set achieve determined leadership development goals overall residents satisfied program perceive worthwhile first years since implementation certification initiative program facilitators improved feasibility participant engagement sustainability program future directions include effectiveness evaluation scale institutions conclusion need pharmacy residency leadership certificate met designing implementing evaluating program unc first years program feasible sustainable valued program participants
purpose important articles infectious diseases pharmacotherapy published peer reviewed literature nominated selected panels pharmacists others expertise summarized summary members houston infectious diseases network asked nominate articles published prominent peer reviewed journals thought major impact field pharmacotherapy list nominated articles general related topics articles specifically related human immunodeficiency virus hiv infection acquired immunodeficiency syndrome aids compiled national online survey members society infectious diseases pharmacists sidp asked select list general articles believed made significant contribution field pharmacotherapy article contributing hiv aids pharmacotherapy sidp members surveyed participated selection general related articles hiv aids related articles respectively highest ranked publications general related articles hiv aids related article summarized conclusion growing number significant related publications year challenging stay current literature review important pharmacotherapy publications may helpful identifying key articles lessening burden
purpose study examined effects tai chi biobehavioral factors associated cardiovascular disease cvd risk women design randomized trial used wait list control group pretest posttest design data collected immediately immediately months following intervention setting study community based central virginia subjects women aged years increased risk cvd intervention week intervention built prior work designed impact biobehavioral factors associated cvd risk women measures biological measures included fasting glucose insulin lipids well reactive protein cytokines behavioral measures included fatigue perceived stress depressive symptoms social support mindfulness self compassion spiritual thoughts behaviors analysis mixed effects linear model used test differences groups across time results women shown decrease fatigue difference group means granulocyte colony stimulating factor consistent study model intervention design significant changes observed months post intervention indicated may help regulate proinflammatory cytokines associated underlying cvd risk including interferon gamma tumor necrosis factor interleukin may increase mindfulness spiritual thoughts behaviors self compassion conclusion study contributes important insights potential benefits mechanisms research may ultimately lead effective strategies reducing cvd risk women earlier cvd trajectory
purpose assess feasibility acceptability efficacy text message based smoking cessation intervention china design study design randomized control trial month follow assessment smoking status setting zhejiang heilongjiang shaanxi provinces china provided study setting subjects total adult smokers china used nokia life tools participated phase smoking education via text message study included intervention high frequency text contact hftc group received one three messages daily containing smoking cessation advice encouragement health education information low frequency text contact lftc group received one weekly message smoking health effects information measures primary outcome smoking status months intervention secondary outcomes include participant perceptions hftc intervention factors associated smoking cessation among hftc participants analysis descriptive analyses conducted assess smoking status acceptability factors associated quitting assessed using multiple logistic regression analyses results quit rates high hftc lftc groups hftc month month months months lftc month month months months significant difference two groups intent treat analysis attitudes toward hftc intervention largely positive conclusion findings suggest text message based smoking cessation intervention successfully delivered china acceptable chinese smokers research needed assess potential impact type intervention
purpose recent study suggests transcranial brain targeted light treatment via ear canals may physiological effects brain function studied functional magnetic resonance imaging fmri techniques humans tested hypothesis bright light treatment could improve psychomotor speed professional ice hockey players methods psychomotor speed tests audio visual warning signals administered finnish national ice hockey league team days transcranial bright light sham treatment treatments given seasonal darkness oulu region latitude degrees north strain players also high matches days daily min dose bright light sham treatment given every morning home transcranial bright light device mean reaction time motor time analyzed separately psychomotor tests analysis variance repeated measures adjusted age performed results time group interaction motor time visual warning signal adjustment age bonferroni post hoc analysis motor time visual warning signal decreased bright light treatment group change significantly sham group reaction time visual signal change either group reaction motor time audio warning signal change either treatment sham group conclusion psychomotor speed particularly motor time visual warning signal improves transcranial bright light treatment professional ice hockey players competition season dark time year
purpose substantial number elderly people suffer cognitive impairment dementia considered various risk factors including masticatory dysfunction however association mastication cognition inconclusive objectives systematic review provide overview literature association mastication cognitive function association mastication dementia incidence elderly people materials methods searches conducted five electronic databases pubmed embase cinhl cochrane library pro quest publications selected met following criteria published written english assessed associations mastication cognitive function cognitive decline dementia among population years old included publications analyzed study design main conclusions strength evidence two reviewers screened abstracts full text articles abstracted data performed quality assessments using critical appraisal tool results total articles cross sectional prospective cohort studies evaluated poorer mastication associated lower cognitive function cross sectional studies steeper decline prospective studies poorer mastication one significant risk factors dementia mild memory impairment mmi cross sectional studies incidence dementia mmi prospective studies conclusions studies point positive association mastication cognitive function including dementia among elderly people elsevier ireland ltd rights reserved
purpose cardiac rehabilitation program structured exercise interventions coronary risk factor reduction reduces morbidity mortality rates following major cardiac event although dose response relationship number sessions completed health outcomes demonstrated adherence high study examined associations number sessions completed within patient demographics clinical characteristics smoking status socioeconomic status ses methods multiple logistic regression classification regression tree cart modeling used examine associations participant characteristics measured intake number sessions completed prospectively collected clinical database results current smoking lower ses nonsurgical diagnosis exerciselimiting comorbidities lower age independently predicted fewer sessions completed cart analysis illustrates combinations characteristics risk profiles predict number sessions completed highest risk profile nonadherence years old current smoker higher ses surgical diagnosis completed sessions average conclusions younger individuals well report smoking economic challenges nonsurgical diagnosis may require additional support maintain session attendance
purpose childbearing age progressively increased industrialized countries impact delay motherhood however requires research methods study sample included prospective cohort healthy nulliparous pregnant women aged years assessed weeks gestation time birth time months birth time effect age psychological biological social variables evaluated maternal psychological symptoms terms depression anxiety assessed parenting stress stress biomarkers cortisol alpha amylase determined mothers questionnaires addressing social functioning family functioning maternal attitudes social support conducted bayesian additive models used analyze data results depressive symptoms showed steep increase starting years age shaped relationship minimum around years old results observed parenting stress cortisol levels increased sharply years age family functioning maternal attitudes social support improved moderately years age conclusions prenatal depressive symptoms higher older women postpartum depressive symptoms parenting stress increased younger older women nevertheless cortisol levels increased older ages postpartum contrast social functioning family functioning maternal attitudes social support improved age conclude social advantages may compensate disadvantages delayed childbearing depressive symptoms parenting stress high cortisol level elsevier ltd rights reserved
purpose chronic illness low levels health literacy affect health outcomes many individuals particularly older adults racial ethnic minorities study sought understand knowledge strengths areas need regarding self management chronic illness order lay groundwork content development intervention increase health literacy maximize patient engagement chronic disease self care patients methods depth qualitative interviews conducted spanish english older adults various chronic illnesses topics included knowledge understanding chronic conditions medications disease self management skills qualitative data coded searching text conducting cross case analysis inductive analysis employed allow patterns themes emerge results emerged themes included social support coping strategies spirituality chronic disease health literacy anger depression participants general overall knowledge chronic illness deficits knowledge regarding illnesses medications conclusion chronic illness self management complex dynamic behavioral process study identified themes leverage patient motivation engage self care personalized manner information guide development intervention promote health literacy optimal disease self management
purpose comparison subjective reasons refusal antimuscarinic treatment state objective economic social psychological health status markers elderly overactive bladder materials methods one thousand seven hundred thirty six patients participated experiment women men aged years average age years took antimuscarinic drugs year control objective parameters carried studying patients medical records use overactive bladder questionnaire short form medical outcomes study item shor form health survey voiding diaries uroflowmetry well income certificates tax inspectorate support documentation expenses drugs results fifty two point six percent patients preserved adherence treatment first months follow period average time reaching day break drugs administration days cases refusal treatment patients referred medical reasons refusal cases disturbance established objective health status markers differences significant follow time percentage refusals treatment social psychological reasons significantly lower percentage individuals statuses altered objectively conclusions significant share elderly patients taking drugs treating overactive bladder inclined overestimate importance health factors influencing decisions underestimate importance social psychological factors urologist take account efficacy evaluation
purpose content validity extent patient reported outcome measure evaluates concepts relevant patient condition treatment george respiratory questionnaire sgrq validated range respiratory conditions study evaluated content validity sgrq patients severe asthma methods qualitative study guided protocol included concept elicitation cognitive debriefing sgrq conducted patients aged years history severe asthma blood eosinophil counts past month past months patients recruited saturation concept elicitation achieved additional concepts identified concepts identified patients mapped sgrq results patient interviews provided concept saturation concept elicitation confirmed sgrq includes commonly reported asthma symptoms impact daily life total patients routinely experienced cough nighttime awakenings shortness breath chest tightness sleep difficulty phlegm mucus wheezing patients reported asthma impacting daily physical activities mood sleep cognitive interviewing confirmed patients understood instructions items response options sgrq nearly half concepts sgrq endorsed patients items scoring weights mentioned patients conclusions study demonstrates sgrq relevant comprehensive content valid instrument assess health status patients severe asthma elsevier ltd rights reserved
purpose differential reinforcement least prompting implemented within context developmentally appropriate play activities effort improve eye contact year old boy pervasive developmental disorder otherwise specified pdd nos three therapists methods multiple baseline design across therapists used examine eye contact year old boy pdd nos maintenance data collected months post intervention results intervention effective improvements eye contact maintained least months post intervention however eye contact readily generalize across communication partners conclusions results suggest eye contact may generalize communication partners directly involved intervention results discussed terms implications practitioners directions future research
purpose given high attrition rate field academic surgery aimed characterise professional personal situations female male academic surgeons well gather data respective perceptions career advancement work satisfaction methods conducted cross sectional survey germany inviting identifiable academically highly qualified female surgeons male counterparts ratio participate anonymous item online questionnaire designed data collected july september results questionnaire sent female male surgeons women men replied average age years respectively respondents identified high degree expertise ambition clarity one professional aims important factors affecting professional career development groups felt workload working hours shifts gender hindrance latter significantly greater importance female surgeons mean work satisfaction scores high female male surgeons predictors support superiors standardised beta coefficient manual aptitude beta contributed incrementally variance high degree work satisfaction observed female surgeons however childcare provided kindergarten crche school care greatest negative predictive value beta conclusions although many parallels female faculty members experience culture academic surgery extent differently male counterparts especially impacted parenthood childcare faculty development programmes need develop strategies improve perceived equality career opportunities respecting individuals requirements well offering gender appropriate career guidance karger basel
purpose implementing merit based incentive payment system mips cms provide special considerations physicians infrequent face face patient encounters reweighting mips performance categories account unique circumstances facing providers aim study determine impact varying criteria fraction radiologists likely receive special considerations performance assessment mips methods data medicare physician supplier file diagnostic radiologists used determine fraction radiologists meeting various proposed criteria receiving special considerations definition fraction patient facing encounters among billed codes determined radiologists receiving special considerations results using criterion proposed cms physicians receive special considerations billing evaluation management services surgical codes diagnostic radiologists would receive special considerations though encounters would represent billed codes among remaining diagnostic radiologists without special considerations cms apply alternative criterion billing evaluation management codes exclusively diagnostic radiologists would receive special considerations threshold patient facing encounters would represent approximately billed codes among remaining radiologists without special considerations conclusions current cms proposed criterion special considerations would result considerable fraction radiologists evaluated basis measures reflective practice beyond direct control alternative criteria could help ensure radiologists provided fair opportunity success performance review mips american college radiology
purpose context problem based learning used preuniversity environment consequently students great deal difficulty adapting method particularly regarding self study reporting phase tutorial session accordingly aim study assess application assessment test multiple choice questions reporting phase tutorial session would improve academic achievement students preclinical stage medical course methods test consisting five multiple choice questions prepared tutors module hand related problem solving process tutorial session applied following self study phase immediately reporting phase tutorial sessions questions based previously established student learning goals assessment applied modules fifth eighth semesters final scores achieved students end module tests compared results overall mean test score introduction assessment test reporting phase conclusion medical course application assessment test multiple choice test reporting phase problem based learning tutorial process increases overall academic achievement students especially sixth semester comparison fifth semester
purpose maternal influences contribute origin allergic diseases mechanisms clear current literature prompted role epigenetics development allergic diseases sought investigate roles regulatory treg cells forkhead box foxp dna methylation process maternal transmission allergic rhinitis susceptibility methods balb female mice mother sensitized intraperitoneal injection dermatophagoides pteronyssinus der day mated normal male mice day day female mice intranasal challenged der continuously normal controls given normal saline way postnatal day female mice offspring sacrificed detect histopathology nasal mucosae cytokines sera mother spleen homogenates offspring treg cells count foxp mrna expressions foxp dna methylation levels spleens results compared normal controls neonatal offspring der stimulated female mice offspring showed elevation interleukin submission spleen homogenates treg cells count offspring decreased remarkably compared normal offspring though difference foxp dna methylation level offspring normal control offspring obvious correlation analysis demonstrated significantly positive correlation foxp dna methylation level mother offspring conclusions influence maternal neonatal offspring develop helper type dominant immune state closely associated recession treg cells foxp dna methylation may mechanism responsible maternal effect still need studies ensure
purpose nivolumab pembrolizumab antibodies programmed death receptor associated distinct immune related adverse effects aes meta analysis randomized clinical trials aims summarize current knowledge regarding toxicity profile agents methods pubmed search conducted february randomized trials needed least one study arms consisting nivolumab pembrolizumab monotherapy control arm containing anti therapy data analyzed using random effects meta analysis risk ratios heterogeneity across studies analyzed using statistics results nine randomized trials patients included meta analysis evidence significant heterogeneity studies pooled relative risk treatment related grade aes grade aes respectively favoring anti therapy versus standard care approach treatment related death patients treated inhibitors increased risk hyperthyroidism hypothyroidism grade pruritus vitiligo also common among patients pooled absolute risks pneumonitis hypophysitis respectively conclusion approved inhibitors well tolerated associated significant low risk severe treatment related aes increased risk thyroid dysfunction pruritus vitiligo
purpose pressure flow studies filling cystometry currently standard diagnostic urodynamic tests lower urinary tract symptoms noninvasive ultrasound based method dimensional monitoring deformation strain detrusor muscle may provide insight detrusor muscle structural dynamic properties related pressure physiological disease conditions materials methods male patient population lower urinary tract symptoms strain detrusor muscle perpendicular bladder wall estimated based dimensional radio frequency ultrasound imaging estimated strain correlated detrusor pressure urinary flow rate using spearman correlation coefficient results twenty men mean age years lower urinary tract symptoms included study ultrasound data acquisition successful patients patients data acquisition failed due plane motion bladder wall voiding result patient movement acquisition estimated strain correlated positively detrusor pressure patients isovolumetric detrusor contraction spearman patients urinary voiding detrusor muscle contraction correlation significantly positive patients spearman conclusions patients lower urinary tract symptoms demonstrated strain detrusor muscle estimated using ultrasound imaging estimated strain correlated positively detrusor pressure optimal results obtained pre voiding phase suggesting ultrasound strain imaging possibly used monitor detrusor muscle activity real time
purpose racial ethnic disparities exist young men contraceptive knowledge study examines whether likelihood receiving sexual health education varies race ethnicity methods examined racial ethnic differences sex contraceptive education school parents multivariable logistic regression models among men aged years using data national survey family growth results nearly respondents reported formal sex education fewer reported formal birth control education parental sex discussions parental discussions specifically birth control multivariable analysis black men less likely white men report receiving formal contraceptive education adjusted odds ratio aor black born hispanic men reported parental sex discussions white men aor aor respectively conclusions nearly respondents reported received formal sexual health education fewer reported receiving education birth control either school home black men less likely report receiving formal contraceptive education published elsevier inc behalf society adolescent health medicine
purpose recent studies linked adolescents media use variety physical psychological social impairments however research neglected adolescents media use complex includes various combinations activities mobile internet browsing calling online gaming use social network sites methods aim study use latent class analysis sample swiss adolescents classify different media usage types based eleven media use variables subsequently associations classes health related quality life hrqol measured kidscreen questionnaire assessed using multivariable regression models adjusted relevant confounding factors results five distinct media use classes could identified low use medium use gaming call preference high social use low use class reported highest high social use class lowest hrqol kidscreen scales moods emotions mean adjusted scores self perception parents home life school environment subscale social support peers pattern reversed low use class indicated least high social use class well conclusions latent class analyses fruitful approach differentiate various media usage types expected better characterize evaluate potential causal associations media use hrqol elsevier ltd rights reserved
purpose researchers increasingly using national population surveys nps understand health gay bisexual men gbm however valid inference surveys depends accurate identification gbm methods asked gbm anonymous online community recruited survey willingness reveal sexual orientation nps results overall indicated would reveal sexual orientation however differences frequencies according sexual orientation relationship status age hiv status living environment education income ethnicity conclusion nps might fully representative gbm due misclassification errors stemming unwillingness disclose
purpose aim paper study feasibility manufacturing customizable trocar cannula system vitreoretinal surgery utilizing commercially available three dimensional printing technology methods digital model trocar cannula system vitreoretinal surgery created using computer aided design cad software printed utilizing laser sintering printer modified abs thermoplastic material trocar cannula prototypes tested pig eyes results customizable digital model created using commercially available cad software three trocar cannulas printed smallest cannulas could printed dimensions trocar cannulas inserted pig eyes performing sclerotomies commercially available mvr blade one cannula broke insertion conclusions study demonstrates feasibility printing trans conjunctival vitrectomy trocar cannula system commercially available print technology printer build material used resulted trocar cannulas functional limitations including minimum size achievable mechanical resistance karger basel
purpose aim study investigate effects acute long term dynamic warm protocol static dynamic balance balance vault performance skilled female gymnast methodology purpose skilled female gymnasts mean age years weight divided two groups control dynamic randomly first protocol included minute jogging second protocol consisted dynamic warm indicators equilibrium four static two legs one leg dynamic situations two legs one leg investigated cameras kistler force plate acute four weeks protocol statistical analysis data performed anova significance level conclusion results showed long term dynamic stretching improve static dynamic balance balance whip performance skilled gymnasts preserve individual risk sports injuries studies needed clarify specific role dynamic stretch various sports activities
purpose eeg rhythms demonstrate changes frequency power spontaneous changes behavioral state well understood metabolic correlates within brain investigate question compare temporal lobe theta delta rhythms resting state functional mri obtained simultaneous eeg methods simultaneous eeg functional mri recorded healthy sleep deprived subjects awake drowsy states scalp electrodes corresponding bilateral temporal lobes used calculate delta theta band power resulting time series used input general linear model final power curves convolved standard hemodynamic response function resulting images thresholded results positive negative correlations unilateral theta delta rhythms present bilaterally different structures differing correlation signs theta rhythm positive correlation present hindbrain peri opercular frontoparietal regions subcortical gray structures whereas negative correlation present parietooccipital cortex delta rhythm positive correlation present parietooccipital cortex negative correlation roughly resembled positive correlations theta rhythm conclusions temporal lobe theta delta rhythms correlated functional mri signal almost mutually exclusive distribution different distributions indicate different corresponding networks normal findings supplement understanding theta delta rhythm significance
purpose objective multicenter cross sectional study investigate relationship nocturnal polyuria patients common lifestyle related diseases overactive bladder special attention hypertension materials methods baseline assessment patients recorded hour urinary frequency volume blood pressure heart rate days stratified groups based mean blood pressure including hypertension controllable untreated uncontrolled hypertension respectively results eligible patients urinary urgency per week nocturnal toilet visits enrolled sites japan patients complete data including hour frequency volume chart collected multivariable analyses showed statistically significant association nocturnal polyuria increasing age gender women men controllable untreated uncontrolled hypertension hypertension however assessed separately men women hypertension heart rate significantly associated nocturnal polyuria women alone respectively lower urinary tract symptoms suggestive benign prostatic hyperplasia significantly associated nocturnal polyuria men alone conclusions current study demonstrates nocturnal polyuria significantly associated age male gender untreated hypertension patients lifestyle related diseases overactive bladder association hypertension nocturnal polyuria significant women alone
purpose pathophysiology detrusor underactivity remains unclear impaired bladder afferent function considered one important etiologies investigated urothelial barrier deficits suburothelial inflammation sensory proteins expressed bladder mucosa patients detrusor underactivity materials methods bladder mucosa biopsies performed patients videourodynamic proven detrusor underactivity study group women stress urinary incontinence controls expression zona occuldens cadherin urothelium tryptase apoptosis levels suburothelium adrenoceptor muscarinic receptors receptor inducible endothelial nitric oxide synthase compared study patients controls results study patients included women men mean age years history diabetes study patients significantly lower cadherin expression higher number mast cells apoptotic cells controls additionally lower expression muscarinic receptors receptors endothelial nitric oxide synthase detected study patients higher expression adrenoceptor study patients positive correlation noted tryptase apoptosis levels expression muscarinic receptor receptor however adrenoceptor expression negatively correlated cadherin expression conclusions urothelial dysfunction increased suburothelial inflammation altered sensory protein expressions bladder mucosa prominent patients detrusor underactivity impaired urothelial signaling sensory transduction pathways appear reflect pathophysiology detrusor underactivity
purpose pretreatment physics plan review standard tool ensuring treatment quality studies shown majority errors radiation oncology originate treatment planning underscores importance pretreatment physics plan review quality assurance measure fundamentally important central safety patients quality care receive however little known effectiveness purpose study analyze reported incidents quantify effectiveness pretreatment physics plan review goal improving methods study analyzed potentially severe critical near miss events within institutional incident learning system collected three year period events originated workflow point prior pretreatment physics plan review remaining events originated pretreatment physics plan review considered study applicable events classified one three categories events detected pretreatment physics plan review events detected potentially detectable physics review events detectable physics review potentially detectable events classified specific checks performed pretreatment physics plan review detected could detected event events associated specific check also evaluated possibility automating check given current data structures comparison similar analysis carried events international safron radiation oncology incident learning system results applicable events institutional database detected could detected pretreatment physics plan review events actually passed physics review however actually detected review events safron database potentially detectable pretreatment physics plan review institutional database three specific physics checks particularly effective detecting events combined effectiveness verifying isocenter verifying drrs verifying plan matched prescription effective checks safron database verifying plan matched prescription verifying field parameters record verify system plan software based plan checking systems available would potential effectiveness detecting events institutional safron databases respectively conclusions pretreatment physics plan review key safety measure detect high percentage errors however majority errors potentially could detected detected study indicating need improve pretreatment physics plan review performance suggestions improvement include automation specific physics checks performed pretreatment physics plan review standardization review process american association physicists medicine
purpose prevalence hyperactive type lower urinary tract symptoms shares overactive bladder oab urge incontinence symptoms respectively investigated possible impact wide range social economic medical factors compliance solifenacin treatment working population methods social economic medical factors well overactive bladder questionnaire oab short form oab bladder diaries uroflowmetry people administered solifenacin year gathered employer documentation results among subjects maintained compliance solifenacin treatment throughout year patients compliance exceeding patients compliance yet less still taking solifenacin months beginning experiment working people whose compliance level least reliably higher average age annual salary treatment efficacy greater treatment satisfaction level well lack satisfaction antimuscarinic treatments higher rate urge diagnosis cohort also featured lower level caffeine abuse lower share salary spent purchasing solifenacin conclusions study shown compliance solifenacin treatment associated number significant medical social economic factors medical factors included type urination disorder severity incontinence symptoms presence side effects treatment efficacy patients satisfaction experience using antimuscarinic treatments among social economic factors strongest correlation compliance patient age employment medicine education annual income level percentage solifenacin purchase expenditures caffeine abuse factors weaker still significant association gender employment transportation industry monthly income level
purpose purpose study examine relationships among self reported screening measures attention deficit hyperactivity disorder adhd psychiatric problems driving related outcomes provincially representative sample adults years older living province ontario canada methods study examined results centre addictions mental health camh ontario monitor ongoing repeated cross sectional telephone survey ontario adults year period measures included adhd measures adult adhd self report scale asrs previous adhd diagnosis adhd medication use psychiatric distress measures general health questionnaire ghq use pain anxiety depression medication antisocial behavior measure antisocial personality disorder scale mini international neuropsychiatric interview apd substance use abuse measures alcohol cannabis cocaine alcohol use disorders identification test audit alcohol smoking substance involvement screening test assist driving related outcomes driving drinking driving cannabis use street racing collisions past year sociodemographics gender age vehicle kilometers traveled results total ontario residents sampled reported valid driver license overall screened positive adhd symptoms asrs screening tool greater percentage screened positive younger reported previous adhd diagnosis medication use distress antisocial behavior anti anxiety antidepressant medication use substance use social problems compared screened negative however statistically significant differences screened positive negative adhd symptoms self reported driving drinks previous hour within hour using cannabis marijuana hash street race collision involvement driver past year sequential regression conducted predict self reported collisions younger age higher weekly kilometers driven showed higher odds collision involvement odds ratio cannabis use ever approached statistical significance discussion study first population based study representative sample adults years older living ontario canada results showed relationship adhd screen collision age sex kilometers driven controlled however analyses based self report screeners psychiatric diagnoses limited sample adhd respondents thus results interpreted caution
purpose purpose study retrospectively evaluate outcomes radiofrequency ablation rfa low risk small papillary thyroid carcinomas ptcs patients ineligible surgery materials methods six ptcs mean diameter range six patients treated rfa three radiologists two hospitals inclusion criteria study pathologically confirmed ptc without cytological aggressiveness single ptc without extrathyroidal extension metastatic tumours ineligibility surgery rfa performed using radiofrequency generator gauge internally cooled electrode medical records reviewed analysed focussing procedural profiles rfa symptoms complications rfa changes tumours follow ultrasonography results rfa results thyroid function tests normal patients months range months follow along significant reduction mean volume four ablation zones completely disappeared two ablation zones exhibited small calcified residues nearly complete disappearance corresponding non calcified solid portions one malignant cells absent assessed fine needle aspiration core needle biopsy transient hypertension mild headache mild neck pain developed procedure subsided without treatment conclusion besides surgery active surveillance conflicting currently used management plans rfa might represent effective safe alternative managing low risk small ptcs especially patients ineligible surgery
purpose purpose study explore association sexual orientation teen pregnancy age years nationally representative cohort young adult females aged years methods total participants waves national longitudinal study adolescent adult health included self reported sexual orientation identity categorized heterosexual three sexual minority groups mostly heterosexual bisexual lesbian combining mostly homosexual homosexual stepwise multivariate regression models fit compare odds teen pregnancy relative risk ratios timing teen pregnancy heterosexual groups adjusting sociodemographic characteristics sexual victimization history sexual risk behaviors results adjusting sociodemographics sexual victimization bisexual women significantly higher odds heterosexual peers teen pregnancy odds ratio confidence interval association marginally significant adjusting sexual risk behaviors bisexuals also likely early age years teen pregnancy contrast lesbian women significantly less likely teen pregnancy heterosexual mostly heterosexual bisexual women final models conclusions expanding extant literature found opposing risk patterns teen pregnancy bisexual lesbian women likely due distinct patterns sexual risk taking findings suggest inclusive teen pregnancy prevention efforts tailored meet unique needs young women particularly bisexuals needed society adolescent health medicine rights reserved
purpose purpose systematic review explore association timing introduction potentially allergenic foods infants development food allergies methods cinahl medline pubmed science direct web science searched using terms solid food complementary food infant feeding combined allergy hypersensitivity articles published english later inclusion criteria primary research articles focus association introduction complementary foods including potentially allergenic foods diets infants less months age development food allergies articles excluded primary research complementary foods without specificity allergenic foods allergic conditions food allergy asthma eczema results initial literature search yielded articles articles met inclusion criteria level evidence study determined sort criteria results found delayed introduction solid foods general allergenic foods particular associated decreased risk allergic diseases among high low risk infants later introduction associated increased risk allergy development clinical implications infants low risk development food allergies providers advise caregivers introduce potentially allergenic foods solid foods months age children show interest eating solids infants high risk peanut allergy evaluated allergy specialist prior introduction peanuts work providers create individualized plan introduction peanuts allergenic foods needed
purpose article standardization document international children continence society iccs represent consensus iccs management pediatric daytime urine incontinence dui materials methods document designed written multi disciplinary core group authors appointed iccs board results based evidence studies experience experts treatment guideline dui assembled standardization document guidelines algorithm management include non pharmacological treatment urotherapy well pharmacological therapy modalities presented dui general along recommendations individual conditions conclusion final document systematic literature review includes relevant research available well experts opinion current understanding daytime incontinence children document illustrates specific treatment dui based exact diagnosis effective mainstay treatment urotherapy combination treatment modalities often necessary wiley periodicals inc
purpose study aims analyse efficacy temperature controlled radiofrequency ablation rfa different tissues materials methods three dimensional cubical model representing healthy tissue studied spherical tumour embedded different body sites considered study liver kidney lung breast thermo electric analysis performed estimate temperature distribution ablation volume programmable temperature controlled rfa employed incorporating closed loop feedback pid controller model fidelity integrity evaluated comparing numerical results experimental vitro results obtained rfa polyacrylamide tissue mimicking phantom gel results results revealed significant variations persist among input voltage requirements temperature distributions within different tissues interest highest ablation volume produced hypovascular lungs whereas least ablation volume produced kidney highly perfused tissue variation optimal treatment time complete necrosis tumour along quantification damage surrounding healthy tissue also reported conclusions results show surrounding tissue environment significantly affects ablation volume produced rfa optimal treatment time complete tumour ablation play critical role minimising damage surrounding healthy tissue ensuring safe risk free application rfa obtained results emphasise need developing organ specific clinical protocols systems rfa tumour
purpose study describes influence attention deficit hyperactivity disorder adhd incidence rates selected injuries methods retrospective cohort study design employed using medical claims data deseret mutual benefit administrators dmba health insurance company employees church jesus christ latter day saints lds spouses dependent children adhd diagnosis injury medication demographic data extracted claims files enrollees aged years results incidence rates adhd times greater males females highest age group years income group greater adhd increased risk selected injuries common injuries involved sprains strains joints open wounds head neck trunk upper lower limb fractures upper lower limb medication significantly protect injury adhd patients rate severe injury fracture skull neck trunk intracranial injury excluding skull fracture injuries nerves spinal cord times common adhd enrollees compared non adhd enrollees injuries times likely adhd respectively conclusions adhd positively associated injuries severe injuries significantly stronger associated adhd less severe injuries
purpose study examined adolescents technology based sexual communication dating partners evaluated associations technology based communication condom use methods participants high school students indicated use technology communicate partners condoms birth control sexually transmitted infections stis hiv aids pregnancy sexual limits sexually active youth also reported frequency condom use results many adolescents used technology discuss sexual health partners rates varying topic girls likely boys discuss hiv pregnancy sexual limits ethnic minorities likely whites discuss condoms stis hiv pregnancy birth control importantly rates consistent condom use three times higher among youth using technology discuss condoms birth control conclusions results provide novel preliminary evidence regarding adolescents use technology discuss sexual health demonstrate links technology based communication condom use among sexually active youth society adolescent health medicine rights reserved
purpose study examined effectiveness universal pressure ulcer prevention bundle upupb applied intensive care unit icu patients combined proactive semiweekly woc nurse rounds upubp compared standard guideline referral based woc nurse involvement measuring adherence evidence based prevention interventions incidence pressure ulcers design study used quasi experimental pre postintervention design phase included different subjects descriptive methods assisted exploring content woc nurse rounds subject setting one hundred eighty one pre postintervention subjects met inclusion criteria admitted icu hours participated study research setting icus located north memorial medical center minneapolis minnesota methods data collection included admission discharge skin assessments chart reviews evidence based interventions patient characteristics woc nurse rounding logs study subjects intact skin admission identified initial skin assessment enrolled prephase subjects received standard care postphase subjects received upupb skin assessments icu discharge chart reviews throughout stay determined presence unit acquired pressure ulcers skin care received analysis included description woc nurse rounds tests guideline adherence multivariate analysis intervention effect pressure ulcer incidence unit assignment braden scale score icu length stay covariates multivariate model based bivariate logistic regression screening results incidence unit acquired pressure ulcers decreased woc nurses logged rounds months focusing primarily early detection pressure sources data analysis revealed significantly increased adherence heel elevation repositioning multivariate logistic regression modeling showed significant reduction unit acquired pressure ulcers intervention increased nagelkerke square value including covariates final model value conclusion upupb woc nurse rounds resulted statistically significant clinically relevant reduction incidence pressure ulcers
purpose assess pharmacist general practitioner advice behaviors related reported patients parents patients using topical corticosteroids tcs long term basis materials methods multicenter cross sectional survey patients aged parents pediatric patients aged month tcs use assessing tcs treatment adherence reasons non adherence beliefs regarding tcs use safety messages regarding tcs received community pharmacists gps family friends internet experiences pharmacist counseling regarding tcs use results total patients parents completed survey respondents reported consistently often always receiving one message regarding tcs risk pharmacist respondents reported told try natural complementary alternative therapies resorting use tcs significantly often pharmacists gps conclusions high rates consistently delivered messages tcs risk gps pharmacists affect patient parent understanding tcs safety may lead treatment non adherence indicates need reeducation groups safety tcs use
purpose assess risk factors outcomes associated fungemia caused six commonly occurring candida species patients without malignancies methods analysis episodes fungemia due common candida species adults based active hospital based surveillance program paris area france results patients isolates solid tumor digestive tract hematological malignancy lymphoma acute leukemia hematology patients significantly younger often pre exposed antifungals often infected tropicalis krusei kefyr often treated first instance echinocandin compared inpatients icu time fungemia icu less frequently infected parapsilosis recent surgery died frequently day day increase crude mortality time icu observed oncology patients patients lack prescription antifungals despite knowledge positive blood culture increased risk death odds infected given candida species compared albicans uneven regarding age gender type malignancy hospitalization icu central venous catheter hiv status intravenous drug addiction previous exposure antifungal drugs compared albicans glabrata parapsilosis associated decreased risk death day day conclusion clinical context underlying malignancy hospitalization icu may relevant initial management candidemia
purpose describe development feasibility self management intervention called help overcome problems effectively hope aimed improving physical psychological wellbeing people living multiple sclerosis method hope innovative week group based manualised self management intervention combining positive psychology theory practice cognitive behavioural therapy cbt participants recruited via local east midlands branch society attended one three hope interventions completed self reported outcome measures week week following outcome measures used multiple sclerosis impact scale multiple sclerosis fatigue severity scale multiple sclerosis self efficacy scale adult state hope scale hospital anxiety depression scale positive negative affect scale results post intervention weeks mean scores decreased physical impact baseline weeks psychological impact baseline weeks also decrease mean fatigue severity scores baseline weeks mean decrease depression scores baseline weeks smaller mean decreases anxiety baseline weeks negative affect baseline weeks refer table mean self efficacy scores baseline weeks mean total hope scores baseline weeks hope agency scores baseline weeks hope pathways baseline weeks positive affect scores increased baseline months participants positively rated intervention quality delivery conclusions feasibility study showed hope acceptable useful people living robust evaluations using randomised controlled trial design longer follow ups needed confirm early promising results hope implications rehabilitation living requires constant adjustments cope unpredictable symptoms self management interventions potential help people living improve quality life feasibility study hope self management group based intervention showed acceptable useful people living
purpose determine exposure young adolescents extremely violent movies design cross sectional school based survey middle school students randomly selected new hampshire vermont middle schools survey contained unique list movies randomly selected top box office hits determined content analysis contain extremely violent material movie titles listed adolescents asked indicate ones seen movie appeared approximately surveys calculated percentage students seen movie representative subsample student population also examined characteristics associated seeing least one extremely violent movie complete survey information obtained students sample primarily white equally distributed gender results average extremely violent movies seen students sample range popular movie scream seen two thirds students overall fifth graders movies sexualized violent content seen many adolescents examples include general daughter rated graphic images related sexual violence including rape scene perverse sexuality natural born killers rated extreme violence graphic carnage shocking images language sexuality seen respectively older students males lower socioeconomic status poorer school performance significantly likely seen least one extremely violent movie conclusion study documents widespread exposure young adolescents movies brutal often sexualized violence given many films marketed teens better oversight marketing practices film industry may warranted society adolescent medicine
purpose evaluate relationship prostatic vessel changes induced cigarette smoking perioperative outcome holmium laser enucleation prostate holep materials methods total postoperative patients benign prostatic hyperplasia bph prospectively analysed department divided two groups smokers non smokers according smoking history transrectal colour doppler ultrasound performed evaluate prostate vascular changes pathologically staining analysed prostatic section chips furthermore postoperative outcomes determined month follow period results preoperative prostate volume significantly decreased smoking patients cpi significantly lower smoking bph patients whereas significantly increased smokers compared nonsmokers histological assays revealed elevated smoking bph individuals presenting increased number microvessels holep duration increased smokers interestingly identified significantly increased overactive bladder syndrome score oabss decreased qmax smoking individuals month follow difference observed preoperatively however significant difference groups observed international prostate symptom score ipss conclusions significantly lower cpi higher values smoking bph patients indicated presence considerable vascular damage subjects moreover cigarette smoking extended surgical duration prolonged recovery period overactive bladder oab syndrome thus integrated treatment suggested various bph individuals
purpose examine young men awareness emergency contraception association contraceptive decision making contributions within relationship methods convenience sample english speaking male patients aged years surveyed regarding childbearing intentions contraceptive awareness including perceived contraceptive knowledge communication birth control providers within relationship results ethnically diverse sample adolescent males recruited mean age years previously sexually active felt important avoid pregnancy reported ever spoken health care provider birth control condoms heard participants heard likely spoken health care provider contraception past feel participate contraceptive decisions relationship discussed contraception partner conclusions counseling young men well methods birth control may empower become actively involved contraceptive decisions within relationship desire fatherhood society adolescent health medicine rights reserved
purpose explore lean methods tools add value programming phase design providing additional resources support project leadership architectural design team background case study based research took place one large academic hospital design efforts surgical tower house operating rooms ors support spaces including pre postop central processing distribution materials management surgical services project leadership asked support lean practitioners design process methods lean exploration loops lels conducted generate evidence support stakeholders made important decisions new building design analyses conducted lels primarily focused relative advantages large footprint floors smaller footprint floors support spaces collocated adjacent ors floor results lels resulted quantifications key operational design features design preferences employees patients horizontal distance travel elevator utilization studies turn complemented architectural design process created opportunities gain buy consensus stakeholders active participation many analyses conclusions found lean tools methods value programming phase focused high level operational design issues help establish buy consensus among stakeholders acknowledging often enough design detail perform accurate analysis
purpose identify evaluate synthesise studies examining barriers enablers survivors critical illness participate physical activity icu post icu settings perspective patients caregivers healthcare providers methods systematic review articles using five electronic databases medline cinahl embase cochrane library scopus quantitative qualitative studies published english peer reviewed journal assessed barriers enablers survivors critical illness perform physical activity included prospero crd results eighty nine papers included five major themes sub themes identified encompassing patient physical psychological capability perform physical activity including delirium sedation illness severity comorbidities weakness anxiety confidence motivation safety influences including physiological stability concern lines risk dislodgement culture team influences including leadership interprofessional communication administrative buy clinician expertise knowledge motivation beliefs regarding benefits risks environmental influences including funding access rehabilitation programs staffing equipment conclusions main barriers identified patient physical psychological capability perform physical activity safety concerns lack leadership icu culture mobility lack interprofessional communication expertise knowledge lack staffing equipment funding provide rehabilitation programs barriers enablers multidimensional span diverse factors majority barriers modifiable targeted future clinical practice
purpose investigate change urinary urgency predictors urgency improvement holmium laser enucleation prostate holep men benign prostatic hyperplasia bph materials methods retrospectively analyzed medical records patients treated holep bph preoperative urgency measuring point urinary sensation scale prostate cancer diagnosed prior holep history prostatic urethral surgery moderate severe postoperative complications neurogenic causes excluded patients improved urgency antimuscarinic medication holep excluded divided patients groups based urgency symptoms months holep improved unimproved urgency improved urgency defined reduction points point urinary sensation scale preoperative clinical urodynamic factors well perioperative factors compared groups results total patients included study voiding parameters patients improved significantly holep seventy one patients improved urgency show improvement history acute urinary retention aur postvoid residual associated postoperative urgency improvement univariate analysis multivariate analysis history aur independent factor affecting urgency improvement conclusions preoperative history aur could influence change urgency holep surgery patients bph
purpose aimed evaluate effect testosterone replacement therapy trt cognitive function depression men testosterone deficiency syndrome materials methods carried prospective placebo controlled trial involving men total testosterone levels baseline significant differences trt control groups noted regarding serum testosterone prostate specific antigen levels regarding scores aging symptoms aging males symptoms scale erectile function item international index erectile function questionnaire cognitive function korean mini mental state examination depression beck depression inventory months intervention total serum testosterone levels erectile function scores significantly increased whereas scores aging symptoms depression significantly decreased trt group significant improvement parameters noted control group notably significant improvement cognitive function noted among patients cognitive impairment baseline cognitive function score received trt conclusions trt may considered men testosterone deficiency syndrome low testosterone levels associated depression cognitive impairment
purpose examined prevalence low testosterone relationship body mass index bmi men lower urinary tract symptoms luts associated benign prostatic hyperplasia bph enrolled clinical trial drug therapy medical therapy prostatic symptoms mtops study materials methods mtops enrolled men total testosterone measured baseline defined single measurement results overall prevalence prevalence increased increasing bmi among men normal weight bmi among overweight bmi men respectively conclusions observed one four mtops study participants baseline measurements prevalence increased markedly increasing bmi findings suggest high prevalence obese men luts bph physicians alert possibility symptoms hypogonadism population
purpose investigated improvements overactive bladder symptoms depressive symptoms solifenacin treatment overactive bladder patients without depressive symptoms methods performed prospective study patients diagnosed overactive bladder july june based beck depression inventory questionnaire test subjects divided group without depressive symptoms points group depressive symptoms points patients administered solifenacin months following outcomes analyzed first visit weeks weeks overactive bladder symptom score oabss international prostate symptom score ipss patients perceptions bladder conchtion beck depression inventory results total patients participated patients completed study outcome measures showed improvements groups weeks especially group questionnaires showed significant improvements baseline week indicating solifenacin effective treating overactive bladder symptoms group group oabss ipss total statistically significant decreases beck depression inventory score baseline weeks observed group group group week week conclusions overactive bladder patients depressive symptoms solifenacin help improve quality life depressive symptoms time
purpose growing focus importance men reproductive health including preconception health ways young men knowledge attitudes beliefs kab predict reproductive paths understudied determine reproductive kab predicts fatherhood status timing residency living child methods reproductive kab fatherhood outcomes analyzed national longitudinal study adolescent health year nationally representative study individuals adolescence adulthood four measures reproductive kab assessed adolescence waves generalized linear latent mixed model predicted future fatherhood status nonfather resident nonresident father adolescent father timing controlling socio demographic variables results men fathers nonresident resident wave higher risky sexual behavior scores significantly increased odds becoming nonresident father odds ratio resident father adolescent father higher pregnancy attitudes scores significantly increased odds becoming nonresident father resident father higher birth control self efficacy scores significantly decreased odds becoming nonresident father adolescent father conclusions young men kab adolescence predicts future fatherhood residency status strategies address adolescent males reproductive kab needed prevention unintended reproductive consequences early nonresident fatherhood society adolescent health medicine rights reserved
purposeimmobilization weight bearing skeletons microgravity results disuse osteoporosis human animals previous study demonstrated electrical stimulation dorsal root ganglion drg implantable micro electrical stimulation system imess could trigger secretion bone anabolic calcitonin gene related peptide cgrp prevent bone loss short term hindlimb unloading rat model study designed investigate whether electrical stimulation drg could prevent bone loss due prolonged unloading methodseighteen adult rats randomly assigned three groups cage control hindlimb unloading hindlimb unloading electrical stimulation hues electrical stimulation applied via imess right drgs vertebral levels hues group weeks resultsfollowing unloading weeks proximal tibia metaphysis shown decrease bone mineral content bmc decrease bone mineral density bmd group significant reduced bone lose increase total bmc decrease total bmd hues group diaphyseal bmd decreased significantly hues group compared group enhancement cgrp expression drgs hues group conclusionthis experimental study proved proposed concept using electrical stimulation drg prevention disuse induced bone loss rat hindlimb suspension model
purposemental health first aid mhfa early intervention training program general audiences promoted means improving population level behavioral health rural communities encouraging treatment seeking study examined mhfa appropriateness impacts rural contexts methodswe used mixed methods approach study mhfa trainings conducted november september rural communities across country data sources posttraining questionnaires completed mhfa participants rural urban trainings states administrative data trainings interviews key informants taught sponsored participated rural mhfa measure rurality rural urban commuting area codes analyses chi square tests conducted questionnaire data structural descriptive pattern coding techniques used analyze interview data findingsmhfa appears aligned key rural needs mhfa may help reduce unmet need treatment rural communities raising awareness issues mitigating stigma thereby promoting appropriate treatment seeking however rural infrastructure deficits may limit communities ability meet new demand generated mhfa mhfa may help motivate rural communities develop initiatives strengthening infrastructure additional tools consultation may needed conclusionsthis study provides preliminary evidence mhfa holds promise improving rural mhfa alone compensate weaknesses rural infrastructure
purposethe data association hormone replacement therapy increased risk venous thromboembolism vte postmenopausal women conflicting observed differences oral estrogen oral estrogen progestogen combination formulations may result bias depletion susceptibles methodswe used united kingdom clinical practice research datalink identify cohort women aged incident cases vte occurring study period identified using nested case control approach rate ratios rrs vte current use oral estrogen oral estrogen progestogen combinations estimated function duration use using conditional logistic regression cubic splines resultsthe cohort postmenopausal women included cases vte matched controls risk vte increased current use oral estrogen confidence interval oral estrogen progestogen confidence interval relative non use assessed duration use risks oral formulations particularly elevated first year use reduced subsequently conclusionthe phenomenon depletion susceptibles considered cohort studies evaluating acute side effects medications achieved estimating risk function current use also duration use copyright john wiley sons ltd
purposethe inappropriate immune response harmless foreign self antigens common feature allergy atopy autoimmune disease influence environmental factors initiation autoimmunity well understood conceivable immune responses allergens may also serve trigger bystander immune reactions including autoimmunity uveitis therefore wanted investigate prevalence allergies atopy patients different types uveitis comparison control cohort methodsin total consecutive patients new onset anterior intermediate posterior panuveitis compared non uveitis control cohort consisting consecutive new referral patients attended specialized outpatient clinics reasons uveitis allergy atopy status well demographic data age gender ethnicity obtained standardized interviewer assisted questionnaires resultsuveitis case cohort control cohort differ significantly allergy status history pollen allergy history drug allergy history food allergy history house dust mite allergy history allergens atopy status history atopic dermatitis history asthma history allergic rhinitis conclusionsour results argue substantial influence allergies atopy onset uveitis
purposethis study aims quantify magnitude missed dispensings commercial claims databases methodsa retrospective cohort study used linking pharmetrics commercial claims database prescription database lrx captures pharmacy dispensings independently payment method including cash transactions included adults dispensings opioids diuretics antiplatelet medications anticoagulants determine degree capture dispensings calculated number subjects following number dispensings databases least one dispensing dispensings missed pharmetrics dispensings missing pharmetrics similar analyses conducted using dispensings unit analysis assess whether dispensing lrx pharmetrics dispensing pharmetrics medication class within days lrx resultsa total subjects included overall subjects number dispensings databases subjects pharmetrics identified dispensing also missed dispensing subjects pharmetrics missed dispensings taking dispensings unit analysis dispensings present lrx captured pharmetrics patterns similar across four classes medications dispensings missing pharmetrics involved subject health insurance plan conclusionscommercial claims databases provide incomplete picture prescriptions dispensed patients lack capture goes beyond cash transactions potentially introduces substantial misclassification bias authors pharmacoepidemiology drug safety published john wiley sons ltd
purposeto demonstrate feasibility mapping intracellular within vivo rodent heart alterations cardiac acid base balance lead acute contractile depression alterations signaling transient reduction adenosine triphosphate atp consumption cardiac contractility may initially beneficial however sustained changes maladaptive leading myocardial damage electrical arrhythmias methodsspectrally selective radiofrequency pulses used excite hco resonances individually preserving signal injected hyperpolarized pyruvate large flip angle pulses placed within three dimensional imaging acquisition exploited mediated label exchange hco images resolution obtained vivo rodent heart technique evaluated healthy rodents scanned baseline high cardiac workload induced dobutamine infusion resultsthe intracellular measured baseline decreased following min continuous adrenergic stimulation conclusionsvolumetric maps intracellular obtained following injection hyperpolarized pyruvate new method anticipated enable assessment stress inducible ischemia potential ventricular arrythmogenic substrates within ischemic heart magn reson med authors magnetic resonance medicine published wiley periodicals inc behalf international society magnetic resonance medicine open access article terms creative commons attribution license permits use distribution reproduction medium provided original work properly cited
purposeto detect consecutive variations internetwork interactions time helps discover underlying dysfunction depressive disorders abnormal interactions resting state functional networks reported depression however little known regarding dynamics crucial networks interact disease related dysfunction materials methodsfunctional magnetic resonance imaging data resting state acquired depressed patients healthy controls twelve resting state networks extracted group independent component analysis interactions calculated sliding windowed granger causality model analysis acquired effective connectivity matrices used construct multislice networks modular structures detected via multislice community detection method resultsno significant differences observed modularity total module numbers depressed patients healthy controls values confidence interval confidence interval respectively however depressed patients exhibited decreased flexibility salience network compared controls corrected confidence interval conclusionsn inclined participate less multiple brain functional modules across resting time depression infrequently changed modular allegiance findings support potential importance neuropathological mechanism depression
pyrroloquinoline quinone pqq coenzyme involved redox cycling system supplemental use pqq examined based properties antioxidant redox modulator although animal study deficiency pqq suggested pqq contributes skin conditions efficacy humans reported present study aimed investigate effects orally administered pqq skin moisture viscoelasticity transepidermal water loss tewl dry skin mouse models healthy female subjects subjective symptom dry skin dry skin mouse model study oral intake pqq diet significantly decreased number mast cells dermis number cells epidermis human study oral intake pqq significantly inhibited increase tewl forearm finally subject questionnaires showed positive impressions improvement skin conditions results suggest oral intake pqq improves skin conditions female subjects dry skin mice compromised skin barrier function
quantification anthropogenic contribution pollution important management environment study water samples bian river suzhou northern anhui province china collected analyzed eight kinds trace metal concentrations analyzed statistical methods quantifying natural anthropogenic contributions results indicate water samples mean concentrations medium coefficients variations indicate water bian river dramatically affected human activities factor analysis identified three sources responsible trace metal concentrations including two natural geological sources one anthropogenic source three sources also determined unmix model anthropogenic contributions total respectively
quitting smoking young adulthood substantially reduce tobacco related morbidity mortality later life depressive symptomatology prevalent among smokers increases risk poor smoking cessation outcomes however integrated behavioral interventions simultaneously target smoking depressive symptoms rarely young smokers included development interventions paper describe session behavioral activation based treatment smoking bats macpherson adapted youth conducted series focus groups young adult smokers depressive symptoms order modib treatment manuals developmentally appropriate subsequently completed small pilot group intervention provide preliminary data feasibility acceptability outcomes provide case series participants order provide clinical illustrations modified bats treatment implemented among young adults pilot study participants exhibited smoking abstinence smoking reductions end treatment well improvement depressive symptoms maintenance levels activation environmental reward participants provided positive qualitative constructive feedback regarding intervention
quorum sensing process bacteria alter gene expression response cell density changes vibrio species low cell density sigma dependent response regulator luxo active regulates two master regulators apha induced opar repressed high cell density opposite occurs luxo inactive therefore opar induced apha repressed vibrio parahaemolyticus significant enteric pathogen humans roles regulators pathogenesis less known examined deletion mutants luxo opar apha vivo fitness using adult mouse model found luxo apha mutants defective colonization compared levels wild type opar mutant show defect vivo colonization restored wild type levels luxo opar double mutant also increased opar apha double mutant data suggest apha important overexpression opar detrimental vivo fitness transcriptome sequencing rna seq analysis wild type luxo mutant grown mouse intestinal mucus showed genes downregulated luxo mutant involved amino acid sugar transport metabolism data suggest luxo mutant metabolic disadvantage confirmed growth pattern analysis using phenotype microarrays bioinformatics analysis revealed opar binding sites regulatory region carbon transporter metabolism genes biochemical analysis five representatives regulatory regions demonstrated direct binding opar five tested data demonstrate role opar carbon utilization metabolic fitness overlooked role regulon
rainfall analysis essential agricultural crop planning water resources management especially water scarcity conditions years rainfall data kharagpur analyzed characterization different seasonal events weibull formula predicted probability mean onset standard meteorological weeks smw june withdrawal smw october probability wet week occurring within smw first order markov chain process shows conditional probability one wet week preceded another wet week varied whereas dry week preceded another dry week varied range stochastic analysis successive wet dry weeks formulates adaptation strategies avoid possible effect wet dry spell cropping seasons wet spell analysis suggests rainwater harvesting control soil erosion maximization water use efficiency probability getting consecutive wet dry days varied range respectively probability getting different magnitude rainfall monsoon weeks week found probability level suggest harvesting excess runoff water future supplemental irrigation
rainfall shortages constrain small holders agricultural production developing countries ongoing climate change shortages may increase volume frequency rainwater harvesting irrigation interesting technology decreases risk therefore one would expect increasing use technology drought prone areas particularly large wealthy farms study investigated relation farm size share irrigated land among smallholders two regions ethiopia also analyzed factors explain share irrigated land using panel data collected random effects tobit model estimated share irrigated land function variables affecting returns market prices source finance expectation formation findings show share irrigated land declines farm size moreover share irrigated land depends distance market ease selling output age aridity distance natural water sources credit access regional differences results question relevance water harvesting farm enlargement however also show safeguarding availability credit improving local infrastructure farmers may extend share land irrigated harvested water elsevier ltd rights reserved
rainfed agriculture nearly cultivated area home human livestock population india contributes country food production even full realizing full irrigation potential country half cultivated area continue rainfed farming highly dependent monsoon rainfall widely believed increasing rainfall variability likely affect livelihoods millions small marginal farmers years come national initiative climate resilient agriculture nicra initiated primarily strengthen research address climate change demonstrate proven resilient practices climate vulnerable parts country farmer participatory technology demonstrations carried since vulnerable districts prone recurrent drought floods extreme weather events like cyclone heat cold wave interventions broadly fall four modules related natural resource management nrm crop livestock fisheries production systems capacity building three years rainfall variability delayed onset prolonged breaks monsoon experienced several parts country total nrm interventions impact resilience situ soil moisture conservation rainwater harvesting efficient recycling demonstrated resulted significant increase crop yields even variable rainfall situations short duration drought flood tolerant varieties paddy pulses oilseeds crops demonstrated covering farmers adaptation gains ranging climate resilient practices technologies found promising mainstreamed national mission sustainable agriculture nmsa flagship government initiative enhancing productivity resilience indian agriculture accordance stated aim national action plan climate change napcc authors published elsevier
rainwater collected rooftop rainwater harvesting rwh system typically considered suitable potable uses primarily poor microbial quality quality stored rainwater however improved basic design maintenance practices construction operation rwh system paper presents microbial analysis rainwater two rwh systems installed seoul national university campus south korea rainwater samples collected different locations within system analyzed total fecal coliforms escherichia coli heterotrophic plate count bacteria within storage tanks water quality improved horizontally inlet outlet points higher quality observed supply point located base tank surface bottom tank first flush rainwater found highly contaminated rainwater quality improved following precipitation catchment surface also significant effect quality rainwater samples collected rooftop exhibited better microbial quality terrace catchment better water quality underground tanks dark storage conditions compared open weirs filters exposed natural light demonstrated importance storage conditions water quality also improved longer storage decrease microbial concentrations observed week storage time findings study demonstrate microbial quality harvested rainwater improved significantly adoption proper design maintenance guidelines discussed paper
rainwater harvesting rwh may effective alternative water supply solution regions affected water scarcity recently become particularly important option arid semi arid areas like mediterranean basins mostly many benefits affordable costs study provides analysis reliability using rainwater harvesting system supply water toilet flushing garden irrigation purposes reference single family home residential area sicily southern italy flushing water demand pattern evaluated using water consumption data collected sample residential customers extended measurement campaign daily water balance simulation rainwater storage tank performed yield spillage algorithm used define tank release rule model performance evaluated using rainfall data different sites located throughout sicilian territory regional analysis provided annual reliability curves system function mean annual precipitation practical applications area study uncertainty related regional model predictions also assessed cost benefit analysis highlighted implementation rainwater harvesting system sicily provide environmental economic advantages traditional water supply methods particular regional analysis identified areas application system would effective
rainwater harvesting rwh plays important role increasing water security individuals governments demand tools enable technical economic analysis rwh systems led substantial body research recent past paper focuses economic aspects domestic rwh urban peri urban environments regard key issues identified discussed including quality quantity harvested water water demand profile scale installation interest rates period analysis real estate value water energy food nexus kenya australia used reference points different economies opposing rwh policies found previous studies financial aspects rwh systems often conflicting results economic analyses ignored full benefits rwh system offer view varying conflicting results need standardize methods economic analysis rwh systems
rainwater harvesting gains ground modern relatively inexpensive simple water saving technology sustainable water management practice saves water reduces stormwater runoff peaks non point source pollution paper order determine optimal size rainwater harvesting tanks two methods daily water balance method dry period demand method used regions greece meet total water demands households residents daily water balance method developed based heuristic algorithm uses daily rainfall data rainfall collection area runoff coefficient available storage volume water demands allowing excess water overflow setting public water supply zero dry period demand method based meeting demand longest annual average dry period according daily water balance method majority regions studied tank sizes meet day demand total daily demand residents roof area exceeding tank size needed meet demands day residents day residents results demonstrate tank size strongly affected dry period length small dry periods lead small tanks exception low rainfall high demand day case low rainfall increases sizes dominant role comparison among dry period demand daily water balance methods showed cases dry period demand method calculates smaller tanks exception areas medium high rainfall high dry period low medium demand day high roof areas therefore main conclusion rainwater harvesting tank capacity strongly affected various local variables formulated however method presented programmed spreadsheet much effort making harvesting tank computations easy
rainwater harvesting residential homes emerging important complement centralized water supplies urban centres around world domestic rainwater harvesting systems provide variety benefits water management contribute sustainable integrated urban water management however risks associated rainwater harvesting requires appropriate mitigation one risk systems become breeding grounds mosquitoes constitute significant health risk spread mosquito borne diseases arbovirus malaria paper explores extent mosquitoes breed rainwater harvesting systems well effectiveness different risk mitigation actions data sourced large scale domestic rainwater tank inspection survey undertaken melbourne analysed using simple bayesian network models observed rate mosquito breeding high identified serious concern health officials water managers common access routes tank system found tank inlet overflow exploring different system set ups found order mitigate risk mosquito breeding tanks potential access routes must adequately sealed complete eradication mosquitos rainwater tanks however may need investigation systems adequate protection inlet overflow still found mosquitoes crown copyright published elsevier rights reserved
rainwater harvesting important technology cities contribute number functions sustainable water management face demand growth drought well detention rainwater increase flood protection reduce damage waterways objective article investigate integrity residential rainwater harvesting systems drawing results field inspection rainwater systems across melbourne combined survey householders situation maintenance behaviour attitudes specifically study moves beyond assumption rainwater systems always operational functional draws collected data explore various reasons rates failure associated pumps pump switches leaving later exploration failure components collection area gutters tank overflows best authors knowledge data like academic literature water sector straightforward bayesian network models constructed order analyse factors contributing various types failures including system age type use reason installation installer maintenance behaviour results show number issues commonly exist failure pumps systems automatic pump switches mediate tank reticulated water systems systems inadequate setups pump limiting use conclusion appears lack enforcement quality controls installation practices sometimes unskilled contractors lack ongoing maintenance checks mechanisms quality control asset management required difficult promote enforce work needed privately owned assets public benefits could better managed crown copyright published elsevier rights reserved
rainwater harvesting modified contour ridges known dead level contours practiced zimbabwe last two decades studies shown marginal soil moisture retention benefits using technique results crop yield benefits lacking paper presents results field study assessing impact dead level contours soil moisture crop yield carried within limpopo river basin experiments carried two study sites one containing silt loam soil another containing sandy soil three treatments constituting dead level contoured plots non contoured plots plots traditional graded contours used site three treatments planted maize crop managed using conventional farming methods planting weeding fertiliser application three treatments done time crop monitoring carried sub plots measuring established every treatment development crop monitored harvesting time data plant height leaf moisture crop yield collected analysis data shows site silt loam soil soil moisture accumulated heavy rainfall dead level contour plots compared control contours graded contour plots higher yield dead level contoured treatment compared non contoured treatment significantly higher non contoured treatment suggests adopting dead level contours situ rainwater harvesting technique results crop yield benefits fields soil type conditions enable runoff generation likely benefit soils low runoff generation elsevier ltd rights reserved
rainwater harvesting tanks reservoirs tamil nadu india support agricultural livelihoods mitigate water insecurity enable ecosystem services however many tanks fallen disrepair private wells supplanted collectively managed tanks dominant irrigation source meanwhile encroachment peri urban development landless farmers prosopis juliflora reduced inflow tank capacity exploratory study presents conceptual framework proposed indicator set measuring water security context rainwater harvesting tanks primary benefits tanks threats functionality profiled precursor construction causal network water security causal network identifies key components causal linkages outcomes water security processes used derive suite indicators reflect multiple economic socio ecological uses tanks recommendations provided future research data collection operationalize indicators support planning assessing effectiveness tank rehabilitation authors published elsevier ltd
random sequences widely used many cryptographic applications hence generation one main research areas cryptography statistical randomness tests introduced detect weaknesses nonrandom characteristics sequence consideration may literature exist various statistical randomness tests test suites defined collection tests efficient test suite consist number uncorrelated statistical tests measures randomness another point view uncorrelated well defined well understood concept literature work apply pearson correlation test measure correlation tests addition define five new methods transforming sequence motivation detect tests whose results invariant certain transformation observe correlation use two methods one direct correlation tests correlation results test sequence transformed form light observations conclude tests correlated furthermore conclude designing reliable efficient suite avoid overpopulating list test functions employing transformations together reasonable number statistical test functions
rapid access lung derived cells stable subjects major challenge pulmonary hypertension field given relative contraindication lung biopsy studies sought demonstrate importance evaluating cell type actively participates disease processes well potential translate findings vascular beds nonlung tissues instance perivascular skin mesenchymal cells mcs utilized posttransplant autopsy lung explant derived cells abcg expressing mesenchymal progenitor cells mpcs fibroblasts skin derived mcs test hypothesis perivascular abcg mpcs derived pulmonary arterial hypertension pah patient lung skin would express gene profile reflective ongoing vascular dysfunction analyzing genetic signatures pathways associated abnormal abcg lung mpc phenotypes pah evaluating lung skin derived mcs identified potential predictor genes detection pah well targetable mechanism restore mpcs microvascular function studies first explore utility expanding study abcg mpc regulation pulmonary microvasculature epidermis order identify potential markers adult lung vascular disease pah
rapid integration global agricultural markets subsequent cropland displacement recent decades increased large scale tropical deforestation south america southeast asia growing land scarcity stringent land use regulations regions could incentivize offshoring export oriented commodity crops sub saharan africa ssa assess effects domestic export oriented agricultural expansion deforestation ssa recent decades analyses conducted global regional local scales found commodity crops expanding ssa increasing pressure tropical forests four congo basin countries sierra leone liberia cte ivoire risk terms exposure vulnerability pressures agricultural expansion countries averaged highest percent forest cover lowest proportions potentially available cropland outside forest areas foreign investment countries concentrated oil palm production median investment area thousand cocoa fastest expanding export oriented crop across ssa accounted global expansion rate thousand however cocoa amounted foreign land investment commodity crop expansion ssa appears largely driven small mediumscale farmers rather industrial plantations land use changes associated large scale investments remain observed many countries although domestic demand commodity crops associated agricultural expansion provide evidence growing influence distant markets land use change ssa
rare events especially could potentially negatively impact society often require humans decision making responses detecting rare events viewed prediction task data mining machine learning communities events rarely observed daily life prediction task suffers lack balanced data paper provide depth review rare event detection imbalanced learning perspective five hundred seventeen related papers published past decade collected study initial statistics suggested rare events detection imbalanced learning concerned across wide range research areas management science engineering reviewed collected papers technical practical point view modeling methods discussed include techniques data preprocessing classification algorithms model evaluation applications first provide comprehensive taxonomy existing application domains imbalanced learning detail applications category finally suggestions reviewed papers incorporated experiences judgments offer research directions imbalanced learning rare event detection fields elsevier ltd rights reserved
raspberry waste obtained two cultivars meeker erm willamette erw subjected evaluation antioxidants antitumour activities potential source phenolics phenolic acids flavonoids identified quantified hplc antioxidant activity tested measuring ability scavenge dpph center dot center dot esr spectroscopy icdpph center dot varied erm erw center dot values varied erm erw cytotoxic activity investigated using vivo model ehrlich ascite carcinoma cells eac mice pretreatment extracts exhibited potent cytotoxic activity eac cells extracts inhibited tumour growth activity xanthine oxidase xod extremely increased pretreated animals activity enzyme complex glutathione reductase glutathione peroxidase gshpx significantly increased study suggests raspberry pomace could used nutraceutic resource functional food ingredient
rates end stage renal disease among australian aboriginal people increasing past decades particularly northern remote areas australia especially disadvantaged communities proteinuria predicts rate loss kidney function common young adults virtually universal years age cumulative independent risk factors include low birth weight recurrent skin infections adult obesity diabetes precursors smoking excessive alcohol intake family history renal disease plausible theory intrauterine malnutrition permanently reduces total nephron numbers overworked adulthood metabolic stresses obesity excess alcohol poor diet higher blood pressures infections starved blood supply smoking although kidney disease often detected already well established active medical intervention offers great rewards control blood pressure preferentially using angiotensin converting enzyme ace inhibitors angiotensin receptor blockers aiirbs combination often stop even reverse kidney damage even ongoing diabetes control poor adequately funded kidney health programs active aboriginal health worker involvement enormously cost effective tight blood pressure control least halves rate disease progression every year dialysis deferred patient could fund appointment health workers addressing underlying social causes epidemic critical national kidney foundation inc
rationale asthma obesity often occur together children unknownwhether asthma contributes childhood obesity epidemic objectives aimed investigate effects asthma asthma medication use development childhood obesity methods primary analysis conducted among nonobese children years age study enrollment southern california children health study chs followed years replication analysis performed independent sample chs children followed mean age years measurements main results height weight measured annually classify children normal overweight obese categories asthma status ascertained parent self reported physician diagnosed asthma cox proportional hazards models fitted assess associations asthma history obesity incidence follow found children diagnosis asthma cohort entry increased risk developing obesity childhood adolescence compared children without asthma baseline hazard ratio confidence interval adjusting confounders use asthma rescue medications cohort entry reduced risk developing obesity hazard ratio confidence interval addition significant association history asthma increased risk developing obesity replicated independent chs sample conclusions children asthma may higher risk obesity asthma rescue medication use appeared reduce obesity risk independent physical activity
rationale despite substantial public interest recommendations promotion good sleep health exist educate health care providers general public importance sleep overall health objectives aim american thoracic society ats statement provide review current scientific literature assist health care providers especially pulmonologists sleep physicians making recommendations patients general public importance achieving good quality adequate quantity sleep methods ats members invited based expertise sleep medicine conclusions based empirical evidence identified comprehensive literature review clinical experience main results focus sleep health children adults including impact occupation sleep public health implications drowsy driving common sleep disorders obstructive sleep apnea insomnia ats statement also delineates gaps research knowledge addressed lead new focused research priorities advance knowledge sleep sleep health conclusions good quality quantity sleep essential good health overall quality life therefore strong recommendation made implementation public education programs importance sleep health
rationale feticide relatively recent development medical technology practice late stage pregnancy termination practice feticide individuals closely exposed particularly fathers researched objective current research aims fill lacuna examining experience israeli fathers whose fetuses underwent feticide israeli policy concerning late stage termination pregnancy unique corresponds israeli social norms emphasize health general healthy children particular methods seventeen interviews men experienced feticide fetuses carried interviews analyzed using principles hermeneutic phenomenology outlined ricoeur results results indicate men experiences arena socially constructed limited gender roles expectations revealed themes address lack socially constructed terminology unclear definition feticide experience men sense obligation protect others procedure ramifications policies regulations used exclude men feticide experience strategies use exclude results revealed narrating experiences men examined behaviors raising retrospectively counterfactual thoughts done differently conclusion findings highlight interface personal experience social phenomenon conceptualizing men two opposing positions one embraces social expectations evident revealed themes questions fathers conformity evident counterfactual thoughts dialogical self theory useful elsevier ltd rights reserved
rationale high intelligence may associated emotional behavioral social difficulties however hypothesis supported little compelling population based evidence study conducted preschool period population based sample method children eden mother child cohort assessed age years behavioral emotional social problems emotional symptoms conduct problems symptoms hyperactivity inattention peer relationship problems prosocial behavior measured using parent rated strengths difficulties questionnaires sdq scores based wppsi iii years relevant covariates children cognitive development also collected results found significant differences sdqscores gifted children full scale children full scale iqin normal range except marginally significant association high emotional difficulties years sensitivity analyses support association high nand emotional difficulties discussion preschool period gifted children seem manifest behavioral emotional social problems children normal elsevier ltd rights reserved
rationale hypertrophic cardiomyopathy hcm prototypic single gene disease caused mainly mutations genes encoding sarcomere proteins despite remarkable advances causal genes approximate hcm cases remain unknown typically small families sporadic cases wherein cosegregation could established objective test hypothesis missing causal genes hcm part oligogenic cause wherein pathogenic variants cosegregate phenotype methods results clinically affected trio hcm underwent clinical evaluation electrocardiography echocardiography magnetic resonance imaging whole exome sequencing pathogenic variants whole exome sequencing data identified using established algorithms family members genotyped sanger sequencing cosegregation analyzed siblings severe course whereas mother mild course variant analysis showed trio shared heterozygous pathogenic variants genes including cardiomyopathy genes ttn alpk siblings also pathogenic variant alathr variant myl known gene hcm sibling father also carried alathr variant unambiguous diagnosis hcm could made concomitant severe aortic stenosis ttn variant segregated hcm except year old boy normal phenotype alpk variant shared affected trio segregate phenotype conclusions posit subset hcm might oligogenic caused multiple pathogenic variants perfectly cosegregate phenotype
rationale polyglutamine disease spinocerebellar ataxia type sca neurodegenerative disease leading severe neurological symptoms development additionally patients affected sca display psychosis earlier motor disorders objective putative psychotic phenotype endophenotype transgenic sca rats examined methods expression schizophrenia like symptoms evaluated longitudinal period onset neurological symptoms sca end transgenic sca rats monoamine neurotransmission investigated along locomotion baseline response amphetamine using vivo microdialysis free moving conditions sensorimotor gating using pre pulse inhibition startle reaction object memory using novel object recognition test index cognitive impairments results presymptomatic sca rats displayed dysregulated monoamine levels baseline response amphetamine compared control wild type rats stage neither amphetamine induced hyperlocomotion sensorimotor gating differed rats symptomatic sca rats developed sensorimotor gating deficits also showed impaired object memory monoaminergic responses remained supersensitive amphetamine conclusions data present study demonstrate neurochemical endophenotype sca rats resembling prodromal schizophrenia findings suggest sensitization monoamine systems arises early adulthood sca rats may predispose express schizophrenia like symptoms later life
rationale report first case tafro syndrome thrombocytopenia anasarca myelofibrosis renal dysfunction organomegaly latin america patient concerns patient year old white woman ashkenazi jewish descent presented history days nausea vomiting fever severe pitting edema legs ascites splenomegaly palpable axillary lymph nodes diagnoses abdominal computed tomography showed bilateral pleural effusion retroperitoneal lymph node enlargement interventions anasarca worsening renal function led admission intensive care unit icu multiple organ failure requiring mechanical ventilation vasopressor medications continuous renal replacement therapy crrt diagnosis tafro syndrome made day admission based clinical findings results bone marrow lymph node biopsies treated methylprednisolone tocilizumab rituximab one week first tocilizumab dose dramatic improvements respiratory hemodynamic status weaned ventilator support vasopressor medications outcomes weeks therapy crrt switched intermittent hemodialysis day patient discharged icu general ward months admission went home lessons provided interleukin measurement available approach suggested cases tafro syndrome order customize treatment
ray tracing computationally intensive task required movie makers create highly realistic images require motion pictures gpus currently dominate hardware accelerators multi billion dollar movie industry however fpgas flexibility potential power efficient accelerators paper investigates proposes fpga acceleration platform easily efficiently explore parallelism ray tracing fpgas integrated luxrender modern open rendering engine major focus proposal cache architecture given memory bandwidth identified bottleneck design domain specific cache study typical memory access patterns ray tracing data structures acceleration hierarchy scene primitives results lead proposal data structure specific cache separating nodes primitives novel node cache replacement policy demonstrate proposed cache architecture successfully alleviates memory bandwidth bottleneck novel replacement policy provide good performance increase small cache sizes may work well complimentary cache along side direct mapped cache evaluation shows scaling number traversal units cache provides increase performance scenes also demonstrate energy bandwidth efficiency proposed platform comparison cpu gpu platform elsevier inc rights reserved
reaction mechanism among indoline dione pyrrolidine carboxylic acid hydroxynaphthalen ethylidene hydroxy carboxamide form aminooxy carbonyl amino methyl hydroxynaphthalen methyl hexahydrospiro indoline pyrrolo imidazole one investigated using density functional theory dft blyp level theory three step reaction occurred via five stationary points including two van der waals complexes two intermediates one transition state entropy change across various steps indicated appreciable interaction overlap within reacting molecules also evident variations geometries optimized species reaction progressed intermediates transition state final product steps leading formation van der waals complexes thermodynamically feasible contrast bimolecular transition step equilibrium constant value transition step found rate determining step study able provide information energetics individual step reaction overall process addition change geometries initial reacting molecules transformed saddle points final product
reactive oxygen species ros excessively generated tumors creating oxidative stress tumor microenvironment investigated hepatic expression nuclear factor erythroid related factor nrf hydroxydeoxyguanosine ohdg hepatocellular carcinoma hcc patients asked ros epigenetically upregulated nrf enhanced aggressiveness hcc cells expression nrf ohdg remarkably increased hcc tissues compared noncancerous hepatic tissues elevated expression ohdg associated poor survival hcc patients ros representative provoked oxidative stress hepg cells indicated increased protein carbonyl content decreased total antioxidant capacity nrf expression ohdg formation markedly increased treated cells compared untreated control treatment antioxidants tocopheryl acetate adenosylmethionine sam effectively attenuated expression nrf ohdg treated cells hepg cells treated significantly higher migration invasion capabilities untreated control cells aggressiveness significantly inhibited sam bisulfite sequencing revealed cpg dinucleotides nrf promoter unmethylated treated cells similar untreated control conclusion robust histological evidence increased antioxidative response oxidative dna damage human hcc tissues demonstrated elevated oxidative dna lesion ohdg associated shorter survival experimentally ros enhanced nrf expression ohdg formation tumor progression hcc cells effects inhibited antioxidants therefore oxidative stress reducing regimens might beneficial diminish ros induced hcc progression
realising rainwater harvesting rwh improves crop productivity smallholder farmers semi arid zimbabwe modified contour ridges traditionally used rainwater management digging infiltration pits inside contour ridge channels order retain water crop fields however scientific studies crop yield benefits infiltration pits conclusive combining field edge rwh methods contour ridges infiltration pits field practices may enhance crop yield benefits thus objective study assess soil moisture maize yield improvement combining infiltration planting pits field experiments conducted rushinga zimbabwe three seasons three sites using split plot design main plot factor field edge rainwater management method rwmm split plot factor tillage method soil moisture content measured weekly using gravimetric time domain reflectometry tdr methods household field survey establish farmers perceptions typology availability field edge rwmm conducted order share experiences enhance stakeholders learning field days held lateral movement soil water measured downslope infiltration pits hence infiltration pits improve maize yield soil moisture content cropping area maize yield higher conventional tillage planting pits yield gap decreased first third year respectively value infiltration pits reducing soil erosion water growing high value horticultural crops inside close pits view shared host farmers stakeholders planting pits option farmers without access draught power fall back method research required determine soil moisture maize yield benefits waterlogging risk fields underlying impermeable layers enhance lateral flow water elsevier rights reserved
real life tracking tasks often show preview information human controller future track follow effect preview manual control behavior still relatively unknown paper proposes generic operator model preview tracking empirically derived experimental measurements conditions included pursuit tracking without preview information tracking preview controlled element dynamics varied gain single integrator double integrator model derived frequency domain application black box system identification method based fourier coefficients parameter estimates obtained assess validity model time domain frequency domain measured behavior evaluated conditions captured commonly used quasi linear operator model compensatory tracking extended two viewpoints previewed target derived model provides new insights human operators use preview information tracking tasks
real time identification tracking joint positions people achieved shelf sensing technologies microsoft kinect camera based systems computer vision however tracking constrained system field view people person occluded camera view position longer followed sight addresses occlusion problem depth sensing tracking systems new tracking infrastructure provides human skeleton joint positions occlusion combining field view multiple kinects using geometric calibration affine transformation verified technique accuracy system evaluation consisting participants stationary position motion two kinects positioned parallel degrees degrees apart results show skeleton matching accurate within within person personal space realistic scenario study groups two people quickly occlude occlusion resolved participants restful api developed allow distributed access occlusion free skeleton joint positions contribution provide system open source
rebirth revolutionary decisive time arts literature society general good example pinnacle human creativity time prominent individual geniuses left samples impressive achievements including leonardo vinci stands one fascinating figures renaissance one creators led greater number myths considered paradigm renaissance homo universalis dabbled varied fields aerodynamics hydraulics anatomy botany painting architecture among others legacy impressive magnitude myth managed develop shape renaissance ideal beauty
receiver electronics dominate power consumption coherent optical transmission systems break bottleneck propose receiver based analog domain signal processing costas loop system simulations show laser linewidths high mhz tolerated making ideal low cost short range applications data centers
receiver strength signal indication based wireless sensor networks offer cheap solution location aware applications final breakthrough systems need fast deployment easy auto configuration study use real life iminds test bed expand two dimensional localization algorithm pseudo third dimension low additional computational time experiments show fast three dimensional algorithm outliers avoids manual calibration algorithm lower position errors maximum likelihood algorithm mean square error cost function furthermore non parametric statistical tests show previously designed two dimensional preprocessing performs equally well pseudo three dimensions preprocessing reduces position error statistically significant way copyright john wiley sons ltd
recent advances development new drugs halt even reverse progression osteoarthritis early stage requires new tools detect early degeneration articular cartilage investigated ability electromechanical probe automated indentation technique characterize entire human articular surfaces rapid non destructive discrimination early degenerated healthy articular cartilage human cadaveric asymptomatic articular surfaces four pairs distal femurs four pairs tibial plateaus used assessed vivo macroscopically electromechanically maps electromechanical quantitative parameter reflecting streaming potentials mechanically maps instantaneous modulus cartilage thickness osteochondral cores also harvested healthy degenerated regions histological assessment biochemical analyses unconfined compression tests macroscopic visual assessment delimited three distinct regions articular surface region macroscopically degenerated region macroscopically normal adjacent regions iii remaining normal articular surface thus extracted core assigned one three regions mixed effect model revealed able statistically discriminate three regions effect size higher assessments indicating greater sensitivity distinguish early degeneration cartilage considering mapping feature techniques also revealed bilateral symmetry moderately similar distribution pattern bilateral joints orthopaedic research society
recent biological studies draw attention question variability cells refer study kiviet published cell controlled culture grows constant rate rate differ one individual another biological question address states follows individual variability growth rate influence growth speed population growth speed population measured malthus parameter define thereafter also called literature fitness even variability growth rate among cells small distribution coefficient variation around even influence malthus parameter would still smaller influence may become determinant since characterises exponential growth speed population
recent clinical trials suggest patients myelofibrosis develop wernicke encephalopathy treated fedratinib specific janus kinase jak inhibitor investigate issue examined fedratinib produce alter course disorder effects thiamine dependent enzyme activity thiamine status influence uptake thiamine animals administered fedratinib days comparable dose used treat human cases myelofibrosis showed evidence clinical signs thiamine deficiency rats treated combination fedratinib exhibited neurological differences progress symptomatic stage compared thiamine deficient animals treatment jak inhibitor compromise erythrocyte transketolase activity thiamine status affected major way unlike animals addition treatment cultured astrocytes fedratinib diminish uptake thiamine cells findings suggest treatment fedratinib lead alter progress support notion administration jak inhibitor directly results development due inhibition thiamine transport known adverse effects fedratinib involving compromised gastrointestinal function may important indirect contributing factor previously reported cases patients myelofibrosis elsevier rights reserved
recent data suggests non trivial amounts human pharmaceutical conjugates potentially entering environmental surface waters compounds could contribute eliciting toxic effects aquatic biota either directly indirectly via conjugation need developing single method quantifying parents conjugates necessary propranolol pro sulfamethoxazole smx respective major conjugates propranolol sulfate pro sul sulfamethoxazole beta glucuronide smx glc successfully simultaneously extracted weak anion exchange solid phase extraction cartridges primary secondary clarification wastewaters north end winnipeg water pollution treatment plant winnipeg canada subsequent separation quantification achieved reversed phase chromatography coupled positive electrospray ionisation tandem mass spectrometry linearity compounds throughout point calibration range recovery rsd ranges across matrices pro smx pro sul smx glc respectively primary secondary filtrates respectively showed significant increase pro significant decrease smx significant decrease pro sul significant decrease smx glc observations indicate removal compounds except pro aqueous phase occurring point stages treatment knowledge first study simultaneously separated quantified two different classes parent compounds two different kinds human metabolite conjugates glucuronide sulfate major urban wastewater treatment plant elsevier rights reserved
recent demands sophisticated agricultural machinery require passive active image sensors mounted vehicle frames impact produced vertical displacements due tire soil interaction mechanical engine vibration causes oscillations reduce data quality activity performed equipment camera spectroradiometer scanner laser paper presents modeling simulation active system stabilization oscillations using fractional order pid proportional integral derivative controller method tuning fractional order pid presented closed loop dynamic system experiments based simulations carried compare performance active stabilization system fractional integer order pid controllers common excitation functions used assess performance active stabilization system along common vibration disturbances acquired field experiment tractor implement set results show active stabilization system presents better performance mitigating vibration displacements accelerations closed loop system fractional pid controller additionally numerical results confirm superior capacity fractional controller based system attenuating vibration disturbance compared classical pid system different machinery operational conditions forward speed load elsevier rights reserved
recent development network technology realize control remote plant digital controller however delay caused data transmission control inputs outputs delay degrades control performance without taking consideration general difficult problem identify delay beforehand also assume plant parameters uncertainty solve problem use reinforcement learning achieve optimal digital control first consider state feedback control next consider case plant outputs observed apply reinforcement learning output feedback control finally demonstrate simulation proposed control method search optimal gain adapt change delay
recent developments domains ambient intelligence ami internet things cyber physical systems cps ubiquitous pervasive computing etc led numerous attempts apply ict solutions occupational safety health osh area literature review reveals wide range examples smart materials smart personal protective equipment ami applications developed improve workers safety health use solutions modifies work methods increases complexity production processes introduces high dynamism thus created smart working environments swe new conceptual framework dynamic osh management swe called proposed framework based new paradigm osh risk management consisting real time risk assessment capacity monitor risk level worker individually rationale context based reasoning swe respective model swe dedicated cps also proposed
recent droughts profound effects ecosystems agriculture forests california highlighted critical need understand drought impacts develop remote sensing based methods drought monitoring objectives work evaluate drought affected areas northern central california using remote sensing aid drought mitigation prediction efforts sustainable forest resource management planning remote sensing provides direct measurement spectral properties moderate spatial resolution landsat compared modeled environmental variables spatial resolution scaled modified perpendicular drought index derived landsat data long term climatic water deficit cwd data year analyzed mpdi strongly correlated cwd precipitation temperature data various forest types coefficient determination range results demonstrate mpdi effective direct method monitor vegetation stress forest declines landscape scale thereby providing land managers stakeholders guidance forest management planning
recent educational policy raised standards students including students disabilities must meet mathematics examine strategies currently used support students learning disabilities authors reviewed literature mathematics interventions students learning disabilities articles reviewed contain various instructional focuses including systematic instructions problem based instruction visual representation review includes discussion interventions used including success interventions used students disabilities students without disabilities implications practice future research also discussed including need continued research middle high school interventions address variety mathematical skills concepts
recent global developments awareness concerns environmental problems led reconsidering built environment approaches construction techniques one alternatives principle low zero energy buildings study investigates potentials energy savings existing multi story building mediterranean region order achieve net zero energy solution increasing fossil fuel prices colored building faculty architecture eastern mediterranean university cyprus chosen target study investigated analyzed order know energy efficiency strategies could applied building reduce annual energy consumption since research objective develop strategy achieve net zero energy existing buildings case study problem solving methodologies applied research order evaluate building design qualitative manner observations addition quantitative method energy modeling simulation achieve desirable results address problems optimizing building energy performance alternative energy simulation made building order make energy comparison analysis leads reliable conclusions methodologies strategies used research applied similar buildings order achieve net zero energy goals
recent insights bioactivation signaling actions inorganic dietary nitrate nitrite suggest critical role microbiome development cardiac pulmonary vascular diseases thought inert end products endothelial derived nitric oxide heme oxidation nitrate nitrite considered major sources exogenous exhibit enhanced vasoactive signaling activity conditions hypoxia stress bioavailability nitrate nitrite depend enzymatic reduction nitrate nitrite unique set bacterial nitrate reductase enzymes possessed specific bacterial populations mammalian mouth gut pathogenesis pulmonary hypertension obesity hypertension cvd linked defects signaling suggesting role commensal oral bacteria shape development formation nitrite bioactive nitrogen oxides oral supplementation inorganic nitrate nitrate containing foods exert pleiotropic beneficial vascular effects setting inflammation endothelial dysfunction ischemia reperfusion injury pre clinical models traditional high nitrate dietary patterns associated beneficial outcomes hypertension obesity cvd observations highlight potential microbiome development novel nitrate nitrite based therapeutics cvd risk factors
recent reports show millisecond delay sound playback android devices time reports identified problem platforms research focuses unresolved audio playback latency problems devices android operating systems examination possible problems application audio playback latency recording measuring methods audio playback latency decreasing methods used achieve smallest possible audio playback delay result proposed solution audio playback delay reduced using opensl api application uncoded audio data device support digitization high performance authors published elsevier
recent research investigated possibility predicting epileptic seizures intervention onset seizure manifestations could envisioned accurate seizure forecasting although efforts better prediction made translation current approaches clinical applications still possible early findings optimistic absence statistical validation reproducibility raised doubts existence preictal state analysis algorithmic studies providing evidence transition ictal state random build leading seizures reviewed general framework reliable algorithmic seizure prediction studies discussing component whole block diagram explored steps along pathway signal acquisition adequate performance evaluation taken account design efficient seizure advisory intervention system present review established potential improvement optimization seizure prediction framework new databases higher sampling frequencies adequate preprocessing electrode selection machine learning considerations elements prediction scheme assessed achieve realistic better chance performances elsevier ltd rights reserved
recent research revealed misinformation gestures influence eyewitness memory however still unclear whether gestural misinformation emulate effects verbal misinformation reporting major details serious crimes investigate salience suggestions provided nonverbally compare made verbally two experiments conducted experiment participants watched footage crime scene presented one two types gestures questioning suggested different interpretations crime results confirmed gestures influenced responses participants altering interpretation crime according information gestured experiment built investigate comparable gestural influence verbal influence results revealed gestural misinformation caused participants alter interpretation crime elicited effects verbal misinformation across two experiments participants unlikely identify misleading gestures report feeling misled results reveal new insights strength gestural misinformation show despite subtle nature communication gestures exert powerful influence eyewitness interviews
recent research uncovered many examples socioeconomic gradients behavior psychological states yet theoretical consensus nature causal processes produce gradients present hunger hypothesis namely claim part reason people lower socioeconomic position behave feel relatively often hungry hunger hypothesis applies particular impulsivity hyperactivity irritability aggression anxiety persistent narcotic use found show socioeconomic gradients review multiple lines evidence showing hunger produces strong increases outcomes also review literatures food insufficiency food insecurity show within affluent societies poor experience substantial burden hunger despite obtaining sufficient excess calories average leads distinctive prediction hunger important mediator relationships socioeconomic variables behavioral psychological outcomes approach number far reaching implications least behavioral psychological differences social groups though persistent current economic arrangements potentially highly reversible changes distribution financial resources food
recent research highlights potential benefits practice without feedback learner strategy knowledge however prior work conducted one one settings short retention intervals compared effects mathematics practice without correct answer feedback immediate week delayed performance classroom setting randomized experiment second third grade children received strategy instruction practiced solving relevant problems small groups within classroom practice children received immediate feedback problem summative feedback problems set feedback practice task immediate feedback led best performance however practice without feedback led higher levels mastery week knowledge retention test thus instructional practices seem less effective first children ultimately result desirable learning
recent research achievement science asserts motivation emotion metacognition important driving forces learning study sought examine relationships two physics class emotions hope anxiety motivational predictors instrumentality self efficacy effects metacognitive problem solving strategies planning monitoring evaluation performance data collected grade spanish students girls structural equation models sem followed bootstrap procedure used examine direct mediated relationships results supported model suggesting instrumentality self efficacy negatively predicted anxiety enhanced hope planning monitoring evaluation performance metacognitive strategies performance negatively predicted anxiety positively predicted hope metacognitive strategies positively predicted performance furthermore hypothesized mediated relations also statistically significant interpretation findings implications physics teaching learning future lines research discussed wiley periodicals inc res sci teach
recent research reveals playing prosocial video games increases prosocial cognitions helpful behaviors gentile greitemeyer osswald results consistent social cognitive models social behavior general learning model buckley anderson social cognitive learning models suggest addition influencing cognitions media content may also influence affect however past studies prosocial video games failed find significant effect affective measures greitemeyer osswald present research examined effects prosocial neutral violent video games state hostility positive affect also examined moderating effects trait aggressiveness trait altruistic helping trait egoistic helping prosocial games reduced state hostility increased positive state affect violent video games opposite effects effects moderated trait physical aggression altruistic participants reported relatively positive affect less state hostility egoistic participants reported relatively aggravated mean feelings aggr behav wiley periodicals inc
recent scholarship declared multiculturalism retreat yet multiculturalist discourses practices remain salient many realms social reproduction paper explores multiculturalism predominantly white churches south region seen significant demographic transformations due immigration church outreach immigrants draws theologies reject racial prejudice call accommodation celebration cultural differences drawing qualitative research pastors congregants article explores multiculturalist practice working reinforcing existing social relationships christian faith communities multiculturalist practices show disrupt racialized hierarchies long embedded white churches simultaneously leave racialized distinctions inequalities intact part maintaining separation immigrants non immigrants case illustrates everyday politics multiculturalism ways boundaries social membership take shape ordinary seemingly non political spaces
recent studies demonstrated correntropy efficient tool analyzing higher order statistical moments non gaussian noise environments although correntropy used complex data theoretical study pursued elucidate properties best use optimization using probabilistic interpretation work presents novel similarity measure two complex random variables defined complex correntropy new recursive solution maximum complex correntropy criterion introduced based fixed point solution technique applied system identification results demonstrate prominent advantages compared three algorithms complex least mean square complex recursive least squares least absolute deviation aforementioned probabilistic interpretation correntropy applied solve several problems involving complex data straightforward way
recent studies noted disproportionately adults histories childhood home placements compared adults without suffer adulthood psychological physical problems however findings based mostly research investigating adults foster care system building foundation study examined adults histories living another type childhood home placement called youth villages situation israeli society reserved youths come impoverished families added challenge immigrants single parent families parents struggle mental health problems substance abuse study aim examine longer term adulthood impact lived youth villages health status making comparisons general population using sample matched age gender youth villages provided lists alumni ages telephone questionnaires administered november december adult youth village alumni compared matched sample general population drawn existing israeli nationwide data set conditional logistic regression used compare health status two groups youth village alumni found experienced many adverse childhood events graduates foster care system however adjusting confounders health status two groups differ dramatically different finding compared studies foster care graduates suggests precursors home placement home placement may always devastating experiences adulthood health repercussions future studies needed examine context process home placement including events preceding placement context assigning placement placement stability placement placement fit youth temperament preparation exit placement
recent studies marsh hydraulics focused tide induced pore water circulation main drive solute transport marsh soil exchange coastal water study revealed another important mechanism provided unstable fingering flow largely modified solute transport paths marsh interior downward penetration salt fingers forced ambient pore water solute plumes move upward exit marsh soil marsh platform relatively high concentrations orders magnitude higher exit solute concentrations tidal creek bed mixing solute ambient pore water marsh interior intensified greatly fingering flow critical distance creek determined based field scale model simulation distinguish tidal circulation dominated fingering flow dominated solute transport zones new transport mechanism implications understanding fate solutes particularly salt marshes low creek densities
recent studies remote detection methods mostly improving variables like sensing distance sensitivity power consumption especially using anisotropic magneto resistive sensors low power consumption high sensitivity detecting subsurface magnetic materials became popular last decades study detecting subsurface materials used fluxgate sensor network even higher sensitivity also minimizing power consumption detecting changing rates horizontal component earth magnetic flux assumed low constituted magnetic measurement system comprises detector system mechanism enables sensors move space data acquisition module processing sending sensor information computer running magnetic flux data evaluation recording software using system tests carried detect anomalies horizontal component earth magnetic flux created different subsurface materials known magnetic chemical geometric properties harmonics horizontal component earth magnetic flux scanned area analyzed help dsp lock amplifier amplitudes high variation harmonics shown computer graphics using graphic information upside surface geometry subsurface material defined identifying magnetic anomalies used scale invariant feature transform sift binary robust invariant scalable keypoints brisks keypoint descriptor used algorithm matching newly scanned image closest image database constituted mines possible metal objects like cans etc results show proposed detection system used instead metal detectors distinguish mines metal materials alert every type metal different geometries said miss alarm count work force time decreased dramatically paper mostly setup system described appendix experimental outputs system different geometries metal samples given also comparing results proposed system additional experiments carried different type sensor chip namely kmz also given appendix elsevier ltd rights reserved
recent theoretical models suggest repetitive negative thinking might key mechanism explaining negative effects maternal psychopathology mother infant relations emerging body research largely supports idea relative importance differences trajectory repetitive negative thinking pregnancy mother infant bonding well maternal depressive symptoms currently unknown therefore investigated associations course maternal repetitive negative thinking pregnancy birth mother infant bonding maternal depressive symptoms longitudinal study overall level repetitive negative thinking significant predictor mother infant bonding maternal anxiety rejection dealing infant four months birth furthermore differences trajectory repetitive negative thinking predicted bonding anxiety rejection overall levels repetitive negative thinking well differences trajectory repetitive negative thinking significant predictors maternal depressive symptoms findings indicate changes repetitive negative thinking pregnancy increase risk postpartum depressive symptoms
recent work laboratory showed endoplasmic reticulum stress induced apoptosis alveolar epithelial cells aecs regulated autocrine angiotensin ang ang system proteasome inhibitor surfactant protein brichos domain mutation induced apoptosis human aecs activating proapoptotic cathepsin reducing antiapoptotic angiotensin converting enzyme ace study tested hypothesis stress induced apoptosis human aecs might mediated influence unfolded protein response upr autocrine angii ang system cells challenged brichos domain mutant induce stress activation upr pathways results showed either mutation activated three canonical pathways upr ire xbp atf perk eif alpha led significant increase cathepsin tace ace ectodomain shedding enzyme eventually caused aec apoptosis however stress induced aec apoptosis could prevented chemical chaperone upr blockers also suggested atf ire pathways might play important role regulation angiotensin system data demonstrate stress induces apoptosis human aecs mediation upr pathways turn regulate autocrine angii ang system also demonstrated stress induced aec apoptosis blocked inhibition upr signaling pathways
recent work suggested presence variety motives mechanisms affect young children sharing decisions yet little known relative impact motives three experiments year old children total current study contrasts two important recipient characteristics suggested play major role early sharing positive social relationship children recipients differences recipients wealth end children could allocate resources friend already possessed lot nonfriend experiments stranger experiment owned resources across age children showed preference share rich friend although tendency stronger older preschool children findings discussed respect theoretical accounts psychological basis early sharing elsevier inc rights reserved
recent years installation photovoltaic system active environmental problem feed tariff system due output fluctuation static var compensator svc made power electronics technology planning install distribution system svc expected maintain voltage svc differs theory operation existing voltage controller load ratio control transformer lrt step voltage regulator svr svc operation makes system impedance changes existing voltage controller may operate effectively study intelligent control method used radial basis function rbf network proposed method reduce effects svc operation including performance characteristics svc conventional method advantage unnecessary arrangement attention svc setup node easy cooperation existing equipment obtained applying method
recently green buildings booming rapidly china order improve performance green buildings energy consumption indoor environment quality ieq green office buildings compared common ones energy data collection physical parameters measurement satisfaction survey results indicate building type mix mode hot summer cold winter zone green buildings energy consumption statistically significantly less common buildings type mechanically conditioned statistically significantly difference green common observed climate zones also found hot summer cold winter zone average energy consumption type lower upper limit values required chinese standard however climate zones upper limit terms ieq building service performance satisfaction users green marked higher common field thermal comfort indoor air quality iaq facilities operating maintenance addition factors affecting buildings energy consumption analyzed order provide guidance enhancing performance green buildings design operation stages elsevier rights reserved
recently group oriented applications unsecure open networks internet wireless networks become popular thus group communication security unsecure open networks become vital concern group key establishment gke protocols used satisfy confidentiality requirement newly started communication session generation sharing ephemeral common key group members study analyze computation communication efficiency gke protocols besides confidentiality security characteristics identification integrity control also required steps protocol implementations thus main contribution work provide computation communication efficiency analysis gke protocols along identification group entities integrity control messages protocol steps specific implementation analysis gke protocols performed group key agreement gka pairing based cryptography group key distribution gkd verifiable secret sharing respectively finally comparison gka gkd protocols basis strong points cost characteristics also provided inform potential users
recently growing interest interaction schizophrenia spectrum disorders ssd substance use disorders sud condition named dual schizophrenia spectrum disorders ssd previous research focused clinical cognitive aspects little known impact comorbidity brain structure functions evidence suggests dual diagnosis patients including ssd show better neurocognitive functioning first years illness followed serious long term decline initial search retrieved articles excluded redundant fulfilling selection criteria thirty three structural functional neuroimaging studies compare ssd ssd patients included groups exhibited brain alterations comparison sud patients healthy controls ssd patients less cognitively emotionally impaired non dual ssd worse healthy controls neurobiological alterations prominent ssd five years illness longer moreover sud characteristics important modulating factors contrary clinical severity specific ssd diagnosis elsevier ltd rights reserved
recently used reductionist integrative approaches pioneered seminal work sanguinetti keating link human arrhythmias gene mutations alter biophysical activity channel proteins begin seek new methodologies treat heart disease faced myriad data clearly simple cell based assays culture models address time change course
recently lot researches focused identity based encryption ibe advantage scheme reduce cost public key infrastructure simplifying certificate management although ibe innovations one weaknesses key escrow problem private key generator ibe knows decryption keys identities consequently decrypt ciphertexts certificate based encryption cbe scheme proposed eurocrypt provides solution key escrow problem allowing certification authority possess partial decryption key comprises full decryption key together user generated private key paper propose new cbe schemes without pairing prove indistinguishability chosen ciphertext attack secure random oracle model based hardness computational diffie hellman problem compared cbe schemes schemes significantly efficient terms performance makes schemes suitable computation limited node sensor wearable device networks copyright john wiley sons ltd
recently artificial intelligence used widely medicine health care sector machine learning classification prediction major field today study existing predictive models based machine learning methods extremely active doctors need accurate predictions outcomes patients diseases addition accurate predictions timing another significant factor influences treatment decisions paper existing predictive models medicine health care critically reviewed furthermore famous machine learning methods explained confusion statistical approach machine learning clarified review related literature reveals predictions existing predictive models differ even dataset used therefore existing predictive models essential current methods must improved
recently bernard reported mirror task produced differences recognition rates sexualized female stimuli presented upright upside orientations based acceptance null hypothesis whereas recognition rates sexualized males better upright upside presentations according sexualized body inversion hypothesis sbih authors concluded male stimuli processed configurally person perception amenable stimulus presentation orientation opposed female stimuli perceived analytically object perception unimpaired presentation mode research critized tarr schmidt kistemaker empirically shown greater asymmetry female male stimuli explain original pattern results utilizing design stimuli subsets bernard replicated results replication failed stricter experimental control counterbalancing original stimulus subsets newly developed symmetry matched stimuli set schmidt kistemaker concluded original effect dependent two important boundary conditions task vulnerable symmetry confounds male female stimuli different stimulus subsets interpretation challenged bernard
recently concerns raised adolescents prolific social media use may cause become less empathic however direct empirical evidence missing research suggests social media use also beneficial adolescents psychosocial development present study aims investigate whether social media use influences empathy surveyed dutch adolescents years twice one year interval results showed social media use related increase cognitive affective empathy time specifically adolescents social media use improved ability understand cognitive empathy share feelings peers affective empathy elsevier ltd rights reserved
recently boysson belleville phillips etal found patients lewy body disease lbd showed significantly lower rates false memories healthy controls using deese roediger mcdermott drm experimental procedure given result could explained practically null rate true recognition lbd group decided replicate study boysson etal including new condition would maximize true recognition rate analyze effect rate false memories specifically drm experiment manipulated within subjects two study recognition conditions immediate condition lbd patients control group healthy older people received different recognition test study list containing twelve words associated non presented critical word delayed condition similar one boysson etal participants received entire series study lists took one recognition test results showed samples immediate condition produced higher corrected rates true false recognition delayed condition although lower lbd patients shows patients capable encoding recognizing general similitude underlying information gist memory right conditions
recently fractional order processes dead time attracted attention many researchers control field pid controllers design techniques available processes dead time suffer lack direct systematic approaches paper simple design parameters tuning approach two degree freedom dof pid controller based internal model control imc proposed processes dead time conventional one degree freedom control exhibited shortcoming coupling robustness dynamic response performance eta dof control overcome weakness means realizes decoupling robustness dynamic performance adjustable parameter eta pid controller directly related robustness closed loop system analytical expression given maximum sensitivity specification parameters eta addition according dynamic performance requirement practical system parameters eta also selected easily approximating dead time term process model first order pade taylor series expressions dof pid controller parameters derived three classes processes dead time moreover compared methods proposed method simple easy implement finally simulation results given illustrate effectiveness method isa published elsevier ltd rights reserved
recently golf become popular sport golfers focus improving skills learning process however many researchers studied found hardness vibration frequency golf club weight angle club head result unstable swing distance accuracy golfers modify swings attitude adapt equipments even change club set sometimes situations cause sports injuries golfers therefore study discusses design optimal club set individual golfers customization decreases cases sports injuries taguchi method applied analyze design optimum club shaft hardness club head weight spine grip weight improved club tested result shows driving distance increased maximum efficiency hitting increased study provides important reference design golf clubs
recently hou introduced novel privilege based visual cryptography scheme pvcs various privilege levels shadow images scheme shadow higher privilege contributes recovered information lower privileged shadow less recovery capability moreover visual quality stacked result depends total sum privilege levels involved shadows reconstruction unfortunately pvc scheme inconsistency contrast recovered image sum privilege levels accordingly enhanced hou pvc scheme epvcs proposed solve inconsistency problem however epvcs general solution implement pvcss arbitrary privilege levels also unequal whiteness shadows paper first extend hou epvcs correct privilege levels achieving consistency contrast sum privilege levels construct pvcs allow arbitrary privilege levels provide equal whiteness shadow elsevier inc rights reserved
recently implicit methods employed method understand underlying attitudes participant also bypassing social desirability biases explicit measures vulnerable unfortunately literature considered viewpoints individuals participate process face validity ascribe test results therefore purpose paper explore individuals respond engaging receiving results implicit test addresses sensitive topic exploring subsequent methodological implications specifically conduct qualitative exploratory study individuals reactions scores race based implicit association test iat using publically accessible comments online message boards overall discuss four themes reporting results questioning iat legitimacy explicit racism group behavior humor using sensemaking theoretical framework discuss findings make recommendations future use implicit tests
recently many countries military adopted cloud big data iot etc order win war therefore favorable environment future battles based soldiers variety iot technologies foster build elite combat forces center expected similar conventional internet environment iot type security threat variety networks data personal information features also identified protocol management therefore enhance security environment future iot based full length necessary study security priority recent survey military professionals shows communications network security important sector addition survey distinguish security field considered fragile study future iot based battlefield see results study reflected professional military security structure effectively threats expected given amount budget
recently liu xue proposed secure two party password based authenticated key exchange protocol utilizing semi group property chebyshev chaotic maps exploit vulnerability protocol paper illustrating line password guessing attack attack password honest user recover attacker without noticed server victim overcome problem propose simple compatible fix
recently many researchers attempted classify facial attributes fas representing characteristics fas attractiveness age smiling context recent studies demonstrated visual fas strong background many applications face verification face search however facial attribute classification fac wide range attributes based regression representation predicting fas real valued labels still significant challenge computer vision psychology paper regression model formulation proposed fac wide range fas fas proposed method accommodates real valued scores probability percentage given fas present input image end two simultaneous dictionary learning methods proposed learn regression identity feature dictionaries simultaneously accordingly multi level feature extraction proposed fac four regression classification methods proposed using regression model formulated based dictionary learning src crc convincing results acquired handle wide range fas represent probability fas pubfig lfw groups adult faces databases compared several state art methods elsevier ltd rights reserved
recently software quality issues emerged recognized fundamental point actualize extensive growth organizations involved software industries still organizations ensure quality products therefore abandoning customers uncertainties software certification branch quality means quality requires measured prior certification admitting process however creating official certification model difficult due deficiency data domain software engineering research participates solving problem assessing software quality introducing model handles fuzzy inference engine mix processes driven application driven quality assurance procedures fundamental purpose suggested model enhance compactness interpretability system fuzzy rules via engaging ant colony optimization algorithm aco attempts discover good rule description set compound rules initially represented traditional single rules proposed model fitting one seen practicing certification models already created software quality domain data modifying context specific data model tested case study results confirmed feasibility practicality model real environment published elsevier
recently aid modern computer graphics image processing techniques made photorealistic weaving methods feasible example fabric tailored halftoning method called stepping dithering developed automatically generating jacquard weave patterns arbitrary given image method faithfully reproduce gradually changing tones fabric high resolution however found methods may induce repeated bothersome visually unappealing patterns input image smooth tones solve problem propose novel methods evaluating dither masks quantitatively also present new algorithm generating artifact free weave patterns optimizing cost function dither masks experiments showed proposed method successfully produces smooth tones fabric
recently normalized subband adaptive filter nsaf algorithm attracted much attention handling colored input signals based first order markov model optimal weight vector paper provides insights convergence standard nsaf following insights step size regularization parameter nsaf jointly optimized minimizing mean square deviation resulting joint optimization step size regularization parameter algorithm achieves good tradeoff fast convergence rate low steady state error simulation results context acoustic echo cancelation demonstrate good features proposed algorithm
recently calls develop ways using participatory approach conducting interventions including evaluating process context improve adapt intervention evolves time need integrate interventions daily organizational practices thereby increasing likelihood successful implementation sustainable changes also highlighted propose evaluation model dynamic integrated evaluation model diem takes consideration model evaluation fitted created iterative intervention process intervention activities continuously adapted based collected data explicitly integrating process context factors diem also considers dynamic sustainability intervention time emphasizes practical value evaluations organizations well importance rigorousness research purposes copyright john wiley sons ltd
recently epoque sophisticated ambient intelligence ami applications mainly based utilisation wide sensor networks together advanced ami approaches concentrate environmental open space outdoor applications although basically focused environmental monitoring enable functionalities collecting environmentally related data passing elaboration paper intend ideas environmentally oriented wireless sensor networks used large scale throughout open natural environment could enhanced using recent ami approaches order beneficial preventing primarily environmentally related problems even disasters focus attention area water management accent two critical water related problems floods management drought stricken periods suggest concept approach solve particular water management problem czech republic using large scale ambient intelligence approach enhancing thus wireless sensor network focused environmental monitoring
recently developed computer adaptive test cat assessing health related quality life hrqol children adolescents kids cat measures five generic hrqol dimensions aims article present study design investigate psychometric properties clinical setting kids cat study longitudinal prospective study eight measurements one year two university medical centers germany validating kids cat consecutive year old patients asthma diabetes juvenile arthritis answered well established hrqol instruments pediatric quality life inventory pedsql kidscreen scales measuring related constructs social support self efficacy measurement precision test retest reliability convergent discriminant validity investigated mean standard error measurement ranged five dimensions equals reliability respectively kids cat measured reliably lower hrqol range convergent validity supported moderate high correlations kids cat dimensions corresponding pedsql dimensions ranging lower correlation found social dimensions instruments discriminant validity confirmed lower correlations non corresponding subscales pedsql kids cat measures pediatric hrqol reliably particularly lower areas hrqol test retest reliability investigated future studies validity instrument demonstrated overall results suggest kids cat promising candidate detecting psychosocial needs chronically ill children
recently reported frequency hepatitis virus hcv genotypes subtypes rapidly changed among intravenous drug users idus yunnan province last years especially true subtype increased frequency assessed hcv positive plasma samples general population hcv nsb fragments amplified sequenced pcr identified four hcv genotypes seven hcv subtypes population genotype predominant distribution frequency followed genotype genotype genotype hcv subtypes frequency frequency common subtypes comparison current data previous results reported idus showed distribution frequencies genotypes significantly different patients idus among hcv subtypes distribution frequencies significantly different patients idu groups moreover phylogenetic analyses showed hcv subtype strains isolated idus intermixed separately clustered hcv subtype predominant among idus also among guangdong province vietnam however hcv subtype predominant among idus among yunnan guangxi provinces results indicate hcv subtype could rapidly spread across china
reclamation wastewater irrigation treatment represents challenge could alleviate pressure water resources address increasing demand agriculture however risks human health must assessed particularly related human enteric viruses resist standard treatments wastewater treatment plants wwtp risks associated exposure viral bioaerosols near wwtp near agricultural plots irrigated poorly documented objectives study better characterize human enteric viruses found bioaerosols near standardwwtp fields irrigated treated propose numeric model assess health risk populations located close irrigated areas particular attention norovirus responsible viral gastroenteritis france water air samples collected various locations largest french irrigated site near clermont ferrand wwtp entrance treatment air activated sludge basins fields irrigated various enteric viruses found water samples collected treatment norovirus abundant genome copies treatment similar treatment low quantities constant emission rate probability decreases log distance emission source doubled information aid development safe water reuse policies terms local setback distance wind conditions wastewater reuse elsevier rights reserved
recognition emotional expressions plays essential role children healthy development anomalies skills may result empathy deficits social interaction difficulties premorbid emotional problems children adolescents schizophrenia twenty six subjects early onset schizophrenia spectrum eoss disorders twenty eight matched healthy controls instructed identify five basic emotions neutral expression assessment entailed presenting visual auditory congruent cross modal stimuli using generalized linear mixed model found significant association handedness age gender however significant associations emerged emotion type perception modality group eoss patients performed worse uniand cross modal emotional tasks specific negative emotion processing impairment pattern relationship emotion identification scores positive negative symptoms self reported empathy traits positive history developmental disorders however found significant association emotional identification scores nonverbal communication impairments conclude cumulative dysfunctions nonverbal communication emotion processing contribute social vulnerability morbidity found youths display eoss disorder elsevier rights reserved
recognizing clinical presentation child abusive injuries crucial review article gives updated summary inflicted intraoral esophageal abdominal visceral injuries including current recommendations recognition evaluation screening value management risk children physical abuse suspected precruising infants intraoral injuries sexual abuse suspected referral specialized centers equipped conduct comprehensive examination forensic testing experienced provider adhering chain evidence protocol recommended abdominal trauma second common cause death children abused diagnosis management injuries require careful consideration routine screening hepatic transaminases guided age child clinical scenario definitive confirmatory computed tomography scan abdomen pelvis performed transaminase levels concerning cases history examination consistent abusive abdominal trauma
recording evoked potentials anesthetized animals people powerful technique non invasively measure function neurons primary output neurons eye assessed pattern electroretinogram perg currently electro physiologic setups perform perg related recordings costly complicated non portable design simple steady state perg system based arduino board amplifier built shield fits microcontroller board arduino digitizes signal sends computer presents stimuli records analyzes evoked potentials used device record perg accurately sensitivity low half microvolt device also designed implement evoked potential recordings simple device quickly constructed used experiments moving systems additionally device used expose students underserved areas research technology would otherwise access
recovery acute spinal cord injury sci characterized extensive heterogeneity resulting uncertain prognosis reliable prediction recovery acute phase benefits patients families directly well improves likelihood detecting efficacy clinical trials issue heterogeneity unique sci fields traumatic brain injury parkinson disease amyotrophic lateral sclerosis one approach understand variability recovery make clinical trial data widely available greater research community contend sci community adopt similar approach providing open access clinical trial data
recycling waste increasingly recognized important resource management strategy however process emits different pollutants including volatile organic compounds vocs sixteen dominant vocs total concentrations ranging presented manual process dismantling television printed circuit boards using electric heating furnaces integrated treatment technique involving spray tower electrostatic precipitation photocatalysis used eliminate highest voc removal efficiency day treatment period removal efficiency mainly due combined effect preferential elimination hydrosoluble vocs efficient interception large sized particles enhanced capture efficiency micro sized particles dominant degradation particle free vocs treatment able remove hydrocarbons average nitrogen oxygen containing aromatic compounds average due hydrocarbons higher dielectric constants risk assessment revealed non cancer cancer risks associated vocs significantly decreased integrated technique applied indicating treatment efficient approach purifying atmosphere protecting human health inside waste recycling workshops elsevier rights reserved
red raspberry fruit intake investigated obese diabetic mice weeks animals fed isocaloric diets freeze dried raspberry control assessed obesity diabetes disease risk biomarkers results showed raspberry intake improved antioxidant status lessened plasma interleukin fold control plasma levels total cholesterol chl low density lipoprotein cholesterol ldl chl resistin higher raspberry group overall enhanced detoxifying cell defenses exerted raspberry intake might due polyphenolics fibre study demonstrates vivo raspberry intake dose achieved human consumption might protect diabetes induced oxidative stress elsevier ltd rights reserved
redirected walking techniques introduced overcome physical space limitations natural locomotion virtual reality techniques decouple real virtual user trajectories subtly steering user away boundaries physical space maintaining illusion user follows intended virtual path effectiveness redirection algorithms significantly improve reliable prediction users future virtual path available current solutions future user trajectory predicted based non standardized manual annotations environment structure tedious inflexible propose method automatically generating environment annotation graphs predicting user trajectory using navigation meshes discuss integration method existing redirected walking algorithms force mpcred automated annotation virtual environments structure enables simplified deployment algorithms virtual environment
refrigeration systems exist different branches industry characterized great energy consumers considerable nonlinear behavior several studies promoted energy costs reduction minimization nonlinearities effects systems model predictive control successfully used stabilize processes presence nonlinearities therefore application refrigeration systems considered promising present study takagi sugeno models developed validated order predict evaporating secondary fluid temperatures based anfis technique adaptive network based fuzzy inference systems vapor compressor chiller equipment prediction performance resulting models analyzed accessed based variance accounted criteria models used basis prediction models several generalized predictive controllers gpc denoted gpc anfis controllers different predictive controllers designed different local rules fuzzy rules global control action assumed weighted sum local controllers experimental tests considered two distinct controllers namely gpc anfis evaporating temperature control means compressor speed variation gpc anfis propylene glycol temperature control means compressor speed variation performed experimental tests setpoint tracking degrees considering constant heat load showed satisfactory results setpoint deviation around degrees therefore anfis technique demonstrated able provide reliable predictive models used generalized predictive control algorithms
regarding issue role playing games rpg experiential learning cycle elc integration rpg use pedagogical simulation tool practice elc learning theoretical foundation essential promoting students effective learning however studies applied rpg simulate practice elc stages namely concrete experience reflective observation abstract conceptualization active experimentation examine learning process enhance effective learning outcomes learners study integrates rpg development use practice derived elc four stages based practising project assessment software development software engineering course results show significant improvement students learning outcomes rpg use importantly study provides major activities findings elc stage via rpg use mapping rpg activities elc stages insightful implications suggestions study discussed elsevier ltd rights reserved
region interest roi detection techniques great importance analysis remote sensing images especially target detection since size image dealt grows substantially improvement spatial resolution current studies aiming specific type object area detection processed images rather small compared size raw data acquired high resolution satellite letter hierarchical task driven roi detection method based saliency density proposed address detection potential object areas large scale remote sensing images proposed saliency density based detection method sdbd integrates bottom top strategies saliency based multilevel histogram contrast presented bottom phase obtain preliminary regions centroid density distribution index cddi defined top scheme refine previous results specifically superpixel segmentation introduced letter narrow roi candidates sdbd capable extracting roi different objects adjusting threshold cddi experiments conducted two data sets extract rois storage tanks residence experimental results demonstrate proposed method effective identifying roi large scale data
regulated school days entail less free living physical activity outdoor stay may jeopardize opportunities cohesive moderate vigorous physical activity mvpa extension children health role outdoor stay school time pupils free living physical education indoor stay studied one academic year pupils aged years four schools mid southern sweden five consecutive days september march may actigraph gtx activity monitors used predictors school stay expressed mean daily accelerometer counts measured per season day grade gender weather time outdoors overall free living outdoors generated highest mean accelerometer counts moderate vigorous outdoor representing total school time contributed total mean accelerometer counts greatest contributors moderate vigorous age weather impacted less inclement weather among older pupils time outdoors seasons would favorably increase school children chances reaching recommended levels
regulatory technological aspects cloud technology showing opportunities gaps rules security accessibility proposal aims addressing problem yet manifested using protocol discussing normative aspects regarding possibility rendering document completely immaterial article proposes protocol uses network unconventional way make document fully immaterial immaterial mean localisable anywhere entirety continue analogy climate want realise fog files rather cloud files distributed public private network injectors extractors access inaccessibility others non location dynamics system offer significant advantages terms security raise legal problems
relational databases remain leading data storage technology nevertheless many companies want reduce operating expenses make scalable applications use cloud computing technologies use nosql database one possible solutions forecasted nosql market growing cagr approximately percent next five years paper offers solution quick data migration relational database document oriented database created semiautomatically two logical levels physical data users refine generated logical data model configure data migration template needed document data migration features implemented relational database browser digibrowser real patients database migrated clasterpoint database offered approach provides means obtain least proof concept new document oriented database solution couple days
relative historic documents newspapers received little attention researchers source archaeological data many historic newspapers digitized placed online traditionally underutilized resource potential yield new information archaeological sites especially heavily developed urban areas sites inaccessible destroyed article methodology proposed archived newspapers might searched data archaeological sites case study using newspapers allen county indiana principal city fort wayne demonstrates utility methodology producing evidence many previously unrecorded archaeological sites
relatives criticism hostility toward emotional overinvolvement eoi patients predictive treatment response relapse although constructs linked relatives attributions patient problems little research yet evaluated attributions specific types problems study examined event specific attributions attributions specifically either disorder related non problems relatives patients anxiety disorders relatives made illness attributions attributing problems patient disorder controllable attributions attributing problems factors controllable patients events reverse pattern non events criticism hostility associated primarily controllability attributions non events contrast presence eoi associated illness attributions non events family based interventions anxiety disorders might need focus relatives controllability attributions broad range patient behaviors reducing tendencies attribute non problems patients disorders
reliably producing software architectures selected architectural styles requires significant expertise yet remains difficult error prone research goals better understand nature style specific architectures relieve architects need produce architectures hand achieve goals paper introduces formally precise approach separate architectural style design decisions application specific decisions uses separate decisions inputs automated synthesizer effect supports model driven development mdd approach architecture synthesis style separate design variable claim possible formalize separation concerns long implicit software engineering research automatically synthesize style specific architectures thereby improve software design productivity quality test claims employed combination experimental systems case study methods developed mdd tool used carry case studies using kitchenham methods contributions include theoretical framework formalizing separation concerns synthesis approach mdd framework monarch results case studies interpret supporting claims work advances understanding software architectural style formal refinement makes application descriptions explicit subject study suggests synthesis architectures improve software productivity quality
religion important influence moral decision making religious reminders may deter people unethical behavior previous research indicated religious contexts may increase prosocial behavior reduce cheating however perceptual behavioral link religious contexts decision making lacks thorough scientific understanding study adds current literature testing effects purely audial religious symbols instrumental music moral behavior across three different sites mauritius czech republic usa participants exposed one three kinds auditory stimuli religious secular white noise subsequently given chance dishonestly report solved mathematical equations order increase monetary reward results showed cross cultural differences effects religious music moral behavior well significant interaction condition religiosity across sites suggesting religious participants influenced auditory religious stimuli non religious participants propose religious music function subtle cue associated moral standards via cultural socialization ritual participation associative learning charge music specific meanings create sacred cues influence normative behavior findings provide preliminary support view hope research investigate closely
remote sensing resource geographic space regular temporal intervals paved way evolution geo spatial information processing knowledge engineering facts acquired technology primarily aims qualitative results support human solving complex tasks solved quantitative relational query processing methods database management systems dbms necessitates need automated inference mechanism built relational databases automated reasoning systematic process formal symbolic representation codify acquired facts enables system infer new knowledge update facts formal representation event attributed spatial entity ease knowledge base proposed using theory allen interval calculus randel rcc objective proposed knowledge base formalize spatial entities geographic region whose temporal attributes events occurring interval time instant successive intervals qualitatively answer event based queries prediction spatial process significance formal approach shown using query evaluation real datasets working proposed knowledge base explained illustrative results towards end work direction enhancement ease explore use discussed
renal cell carcinoma rcc often expresses high density sialic acid rich glycoproteins helps late stage cancer cells enter blood stream urine blood diagnosis complex time consuming process study developed facile non invasive electrochemical cytosensor early detection rcc urine samples based specific recognition aminophenyl boronic acid apba polypyrrole ppy bovine serum albumin bsa incorporated submicron particles bsa deposited gold electrode take advantages excellent properties biomaterials including good biocompatibility low cytotoxicity excellent electro conductivity increase biosensor sensitivity apba molecules integrated recognize sialic acid cell surface optimal conditions impedimetric cytosensor exhibited good linear relationship logarithm cell concentration cells low detection limit cells therefore electrochemical impedimetric biosensor offers potential approach bedside rapid detection rcc clinical applications
renal involvement idiopathic inflammatory myopathies uncommon previously thought develops one fifth patients clinical presentation includes either acute kidney injury chronic glomerulonephritis former usually develops abruptly acute phases rhabdomyolysis case kidney injury caused toxic effects myoglobinuria kidney tubules including cast formation iron induced oxidative stress development third space injured muscles latter instead autoimmune nature pleomorphic histological picture indolent course exception crescentic glomerulonephritis accurate diagnosis management crucial patients timely evaluation treatment prevent complications setting rhabdomyolysis induced acute kidney injury necessity dialysis avoided aggressive hydration alkalinization order force diuresis avoid acidosis hyperkalemia immune mediated glomerulonephritis renal biopsy undoubtedly value diagnostic process add prognostic therapeutic information forms development chronic kidney disease prevented least delayed institution modification immunosuppressive treatment moreover use drugs inhibit renin angiotensin aldosterone system lifestyle modifications smoking cessation weight loss salt restriction also value reducing proteinuria progression kidney damage review summarized currently available evidence different case series attempt provide readers complete practical notions needed handle delicate patients
renewable energies general considerably increased penetration electrical power systems however intermittent energy sources large amounts power could create problems proper operation electrical network sense paper studies effects wave energy generation voltages distribution network using ieee bus test feeder addition corrective actions based reactive power compensation reactive compensation grid side converter wave energy converter use statcom presented results show use grid side converter reactive power compensator improves voltage quality network although capability mitigate voltage fluctuations limited use complementary external statcom provide extra compensation needed authors published elsevier
repetitive transcranial magnetic stimulation rtms non invasive safe alternative electroconvulsive therapy treatment resistant depression trd rtms changes brain spect perfusion remotely identified within medial temporal limbic areas local effects found within left dorsolateral prefrontal cortex dlpfc coil functional changes connectivity may underlie remote effects interestingly functional connectivity recently investigated using perfusion spect abnormalities identified trd patients aim present study evaluate perfusion connectivity spect changes trd patients rtms left dlpfc hypothesize changes dlpfc networks may explain remote hypoperfusions found rtms fifty eight trd patients underwent brain spect high frequency rtms left dlpfc whole brain voxel based changes perfusion evaluated spm inter regional correlation analysis performed study left dlpfc functional connectivity corrected cluster volume rtms patients significantly improved beck depression inventory score considering reduction threshold patients identified responders rtms perfusion changes found locally within left dlpfc remotely within bilateral temporal lobes including limbic areas inter regional correlation spect analysis brings decrease connectivity left dlpfc cingulate medial frontal cortex bilateral medial temporal limbic areas relation clinical response rtms dlpfc trd patients leads remote temporal hypoperfusions relation changes functional connectivity dlpfc default mode network especially including medial temporal limbic areas
replacement metacarpo phalangeal joints mcpj silastic swanson implants help decrease pain stiffness allow improved function rheumatoid arthritis lack patient reported outcome measure prom studies assessing efficacy procedure aim study report change function pain stiffness satisfaction following swanson mcpj replacement using patient reported outcomes rheumatoid population combined results patients hands swanson mcpj arthroplasties mean follow months assessed using validated sacrah questionnaire separate satisfaction questionnaire radiographic evaluation performed insure correct alignment hinged prosthesis postoperatively attempt made identify predictors radiologically clinically data analysed study interpreted context number hands survivorship defined implant fracture loosening revision mean total functional outcome score improved total pain outcome improved total stiffness outcome improved postoperatively results obtained satisfaction questions revealed patients would retrospectively elect procedure report two postoperative complications group superficial wound infections radiographically mcpjs showed improved alignment however five patients reported worsening pain four patients reported increased stiffness four reported reduced function postoperatively one operation mcpj swanson require implant exchange one implant revised implant survivorship patient satisfaction functional surrogate markers overall favourable results support continued use swanson silastic arthoplasty advanced
report european congress clinical microbiology infectious diseases eccmid april amsterdam netherlands invasive fungal infections major threat lives increasing number immunocompromized patients neutropenic hemato oncology patients especially high risk since effective antifungal treatment prophylaxis critical improve survival patients emergence antifungal drug resistance become increasing cause concern mortality invasive fungal infection also remains high even patients receive appropriate timely antifungal therapy important topics among discussed clinical microbiologists infectious disease physicians countries attending european congress clinical microbiology infectious diseases
requirements prioritization one important parts managing requirements software development process plays role success failure software product software product wrong fail right requirements prioritized right time thus need vast complete requirements prioritization technique model spans factors must considered prioritizing requirements whether traditional software development agile software development several requirements prioritization methodologies aid decision making prioritizing requirements importantly many lacks account important factors significant influence prioritizing requirements requirement prioritization methodology takes account important factors time human behavioral factors influence prioritizing requirements required new model technique expected overcome lack existing prioritization techniques considering time gap factor human behavioral factor extensive study literature agile methodology requirements elicitation prioritization done find factors influence decision making process requirement prioritization found agile methodologies scrum deliver products increments time gap increment approximate weeks time lapse could cause human behavioral change either market demand personal reason thus influences prioritization decision factors could termed time factor human behavioral factors thus requirement prioritization technique model needed takes account factors prioritizing requirements whether traditional software development agile software development
research consistently demonstrated children living low income families particularly poverty greater risk child maltreatment however causal evidence relationship sparse use child maltreatment reports national child abuse neglect data system child file investigate relationship changes state minimum wage changes child maltreatment rates find increases minimum wage lead decline overall child maltreatment reports particularly neglect reports specifically increase minimum wage implies statistically significant decline neglect reports decline concentrated among young children ages school aged children ages effect diminishes among adolescents significant find effect increases minimum wage varies based child race findings robust number specifications results suggest policies increase incomes working poor improve children welfare especially younger children quite substantially elsevier ltd rights reserved
research identified multitude demographic psychological contextual factors associated violent offending among youth however much previous research focused single factors little known effects various factors tandem present study examines whether certain community factors impact effects race psychopathology violent crime multivariate analyses used investigate race psychopathology combinations moderating influence exposure community violence sample youth youth without antisocial personality disorder apd psychopathy less violent diagnostic groups black youth less likely psychopathy compared whites hispanics however black youth apd psychopathy twice likely exhibit violent crime versatility furthermore black hispanic youth demonstrating aggressive conduct problems committed greater number violent crime types whites relationship qualified black hispanic youth apd psychopathy exposed community violence committed greater number violent crime types compared whites results suggest prevention intervention strategies consider individual community level factors
research tried identify risk factors increase likelihood difficulties externalizing behavior relations individual environmental factors externalizing behavior especially documented child oriented parent oriented interventions designed order decrease externalizing behavior preschoolers date however research largely compartmentalized therefore known whether child oriented parent oriented intervention effective reducing externalizing behavior aim current study answer question comparing two week child two week parent oriented group programs sharing common experimental design done pseudo randomized trial conducted year old children displaying clinically relevant levels externalizing behavior assigned one four interventions control participants allocated waiting list results indicate four programs focusing specific target variable social cognition inhibition parental self efficacy beliefs parental verbal responsiveness effective reducing externalizing behavior among preschoolers effectiveness moderated neither orientation toward child parent content suggesting several effective solutions exist improve behavioral adaptation preschoolers second important highlight study thanks comparable effect sizes brief focused programs appear reasonable alternative long multimodal programs may cost effective children families
research objectives european market football club investors undergoing significant transformation german clubs opening strategic investors french clubs taken private majority investors english top league clubs experiencing influx foreign investors economic legal politics played important role deregulation closed member associations research methods paper aims summarize history market situation big five european leagues review available theory empirical evidence incorporations public private investors suggest research gaps deserve attention authors also constructed unique database covering owners two premium divisions england france germany italy period results findings available articles growing research field football club investors cover various theoretical areas application property rights theory european football clubs addition several empirical papers analyze financial sporting impact domestic foreign private investors public listings studies highlight increasing importance club ownership rat race european football implications nevertheless research gaps remain studied appropriate depth first empirical studies analyze impact incorporations german football entry private majority investors france furthermore future research may address paradox listings england additional listings continental europe finally article identifies impact foreign investors multi ownership synergies promising research fields respect article provides managerial implications football club owners managers regulators
research distributive justice indicates preschool age children take issues equity merit account distributing desirable items often prefer see desirable items allocated equally third party tasks contrast less known development retributive justice study year old children adults directly compared development reasoning distributive retributive justice measured amount rewards punishments participants allocated recipients differed amount good bad things done also measured judgments collective rewards punishments found developmental trajectory thinking retributive justice parallels distributive justice year olds likely prefer equal distributions rewarding aversive consequences older children adults preferred deservingness based allocations year olds also likely judge collective rewards punishments fair tendency declined increasing age results also highlight extent notion desert influences thinking distributive retributive justice desert considered equally participants allocated reward punishments judgments collective discipline participants focused desert cases punishment compared reward discuss results relation theories preferences equality versus equity theories desert differentially weighed across distributive retributive justice literature moral development fairness
research posttraumatic stress disorder ptsd chronic childhood abuse revealed traditional trauma treatments often fail fully address complicated symptom presentation including somatic complaints loss awareness one emotional physical present moment overall lack integration self body mindfulness based intervention hatha yoga shows promise complementary treatment focuses personal growth addition symptom reduction qualitative study explored experiences adult women ptsd related chronic childhood trauma participated week trauma sensitive yoga tsy class specifically examining perceived changes symptoms personal growth five themes identified reflect participants feelings gratitude compassion relatedness acceptance centeredness empowerment results implications research clinical work presented
research psychopathology experimental studies sleep restriction support relationship sleep disruption internalizing externalizing disorders objective current study extend research examining sleep impulsivity antisocial personality traits internalizing traits university sample three hundred eighty six individuals males ages years wore actigraphs days completed established measures disorder linked personality traits sleep quality personality assessment inventory pai triarchic psychopathy measure barratt impulsiveness scale pittsburgh sleep quality index expected sleep measures questionnaire scores fell within normal range values sex differences sleep personality consistent previous research results similar findings predominantly male forensic psychiatric settings higher levels impulsivity predicted poorer subjective sleep quality women men consistent well established associations depression sleep higher levels depression sexes predicted poorer subjective sleep quality bidirectional analyses showed better sleep efficiency decreases depression finally moderation analyses showed gender primary role sleep efficiency marginal effects found observed relations sleep personality traits typical university sample add converging evidence relationship sleep psychopathology may inform understanding development psychopathology young adulthood
research similarity constructs dyadic similarity personality stability judgment agreement accuracy frequently find associated positive outcomes however methodological pitfall associated common overall similarity indices term normative desirability confound ndc regularly result similarity constructs apparently positive effects reality essence individual estimated similar another person common indices strongly indicate individual desirable characteristics consequently correlates overall similarity indices often interpreted indicating beneficial effects desirable characteristics without needing attribute additional salutary effect similarity show confound present overall similarity estimates wide range constructs personality traits attitudes emotions behaviors values accounted discuss larger implications understanding similarity constructs
research wet steam condensing flow problem important improving steam turbine efficiency paper derived total variation diminishing tvd discrete method two dimensional curvilinear coordinate system discretizes control equation via difference scheme accurately describe transonic flow compressible gas capture abrupt parameter changes method applied improve shock wave capture accuracy cascade passage cascade white test chosen study object obtain test data verify accuracy proposed model calculation results indicate condensation process significant impact local flow parameters distribution gradient parameters liquid phase relatively large condensation position degree subcooling wet steam primary factor influences parameter distribution liquid phase main flow
research reported paper aims improve extraction cucumber leaf spot disease complex backgrounds improved fuzzy means fcm algorithm proposed paper first three runs marked watershed algorithm based hsi space applied isolate target leaf second distance pixel cluster center defined vertical bar vertical bar vertical bar third pixel neighborhood mean gray value constitutes two dimensional vector grayscale information calculated sample point rather fcm grayscale finally neighborhood mean gray value pixel gray value weighted matrix evaluate robustness accuracy proposed segmentation method tests conducted cucumber disease images vegetable disease database results show average segmentation error proposed method provides effective robust segmentation means sorting grading apples cucumber disease diagnosis easily adapted imaging based agricultural applications elsevier rights reserved
research suggests early care education ece services particularly center based ece may help prevent child maltreatment also mitigate negative developmental outcomes associated child maltreatment also preliminary evidence suggest ece could reduce likelihood maltreatment allegations substantiated child welfare authorities result children placed home care however little known rates ece participation among children receiving child welfare services factors determine ece participation population data first wave national survey child adolescent wellbeing nationally representative sample children referred united states child welfare system cws suspected maltreatment used measure frequency year olds participate center based ece additionally logistic regression analyses explored effects maltreatment type substantiation children living arrangements parents relatives foster parents outcome controlling range child family covariates associated ece participation general population results indicate less third year olds receiving child welfare services participating center based ece among various categories maltreatment type measured reported cws suspected physical abuse associated decreased odds center based ece participation however types maltreatment substantiation living arrangement unrelated center based ece participation findings suggest despite recent efforts federal government promote ece participation cws supervised children vast majority young children cws receiving center based ece physically abused children particularly disadvantaged comes accessing services elsevier ltd rights reserved
research syntheses education particularly meta analyses best evidence syntheses identify evidence based practices combining findings across studies whose constructs similar enough warrant comparison yet constructs come preloaded social historical political cultural assumptions anticipate research problems framed solutions formulated information research syntheses provide therefore incomplete assumptions underlying constructs critically understood describe demonstrate new systematic review method critical construct synthesis ccs unpack assumptions research synthesis show framings educational problems made possible constructs excluded methodological elimination decisions taken consideration
research elucidate early alterations higher cognitive processes adolescents bpd rare study investigated differences dual task performance adolescents bpd stress non stress conditions study sample comprised female adolescents bpd healthy controls impact stress dual task performance measured using standardized stressor self reports distress measures heart rate obtained measure stress reactivity group differences task performance stress conditions performance auditory task decreased groups without significant group differences healthy controls showed increase mean stress induction compared change bpd group finding attenuated response acute stress adolescent patients bpd may contradict current theories affective hyperresponsivity bpd based biologically determined mechanism
researchers extensively documented sociodemographic predictors race gender attitudes mechanisms attitudes formed change despite growing recognition important status characteristic sexual orientation received little attention predictor americans race gender attitudes using nationally representative data american national election survey time series study compare heterosexuals lesbian gay bisexual lgb people attitudes sexuality race gender attitudes lgb people hold significantly liberal attitudes sexuality race gender heterosexuals even upon controlling powerful sociodemographic determinants social attitudes however substantial proportion sexual orientation gaps attitudes especially race gender explained lgb people relatively liberal political ideology findings provide evidence necessity incorporating sexual orientation future assessments americans social political attitudes elsevier inc rights reserved
researches foster care rarely involve birth children foster family concepts foster parenting fraternal experiences contribute understand relationship bond forged foster birth children study sample included birth adolescents ranging age semi structured interviews analysed using textual data analysis software alceste results show existence singular dynamic professional socialization birth adolescents certain risk feeling overwhelmed relationship problems contrasting family membership analysis singular fraternal experiences allows assess importance commitment greater recognition efficient support societe franyaise psychologie published elsevier masson sas rights reserved
researching industrializing new pharmaceutical form results impressive amount waste due methods used despite numerous reports addition pharmaceutical ingredients environment effect environment nanogram level remains largely unknown thus proposed retain toxic compounds using dowex resins biomucoadhesive tablets containing miconazole nitrate antifungal medication study demonstrates reduction water pollution using pharmaceutical forms miconazol nitrate anions time proposed method also utilize anti fungal substances recovering ion changing resins pollutant examined study nitrate anions resin represented dowextmnsr pharmaceutical form disaggregated distilled water resulting solution filtered dowex resin chemical test reports created parameters registered values allowable wastewater limits ionic exchange method study anion nitrate ended waste preparation new pharmaceutical forms antifungal effect retained anion nitrate percentage confirmed different determinations biomucoadhesive miconazol nitrate tablets disaggregated distilled water
resilience dynamic multifaceted process individuals draw personal contextual resources difficult situations resilient people use specific strategies learn situation without overcome stressors inherent veterinary work including long work hours ethical dilemmas challenging interactions clients resilience important component professional quality life however resilience health professionals received attention received little veterinary field cross sectional study veterinary students six veterinary schools australia completed online survey responses veterinary students reached threshold considered highly resilient using brief resilience scale approximately one third classified low levels resilience final linear multiple regression model predictors resilience included nonjudgmental nonreactive mindfulness five facet mindfulness questionnaire self compassion neff self compassion scale students higher nonjudgmental nonreactive mindfulness self compassion higher resilience scores findings indicate fostering qualities mindfulness self compassion may aligned strengthening veterinary student resilience importantly factors help veterinary students develop capacity resilience identified intervention programs targeted educate future veterinary professionals high quality life professional personal
resilience related students well academic success challenges associated students historically underrepresented backgrounds non traditional students frequently reported resilience received lesser attention primary purpose study compare levels resilience traditional non traditional students first year students participated online mental health survey included standardised measure resilience demographic questions item exploring students perception non traditional results showed students considered non traditional life aspects including age employment parenting responsibility significantly higher resilience compared self identified traditional students however resilience levels students deemed non traditional domains household income cultural background differ significantly traditional students findings show life experiences commonly affiliated mature aged student including work carer may contribute higher resilience implications relation practice future research discussed
resolution diarrhea weight gain normalization nutrient malabsorption addition histopathological changes also normalize histopathological response appears time dependent sex dependent age dependent compliance gluten free diet difficult costly resulting poor compliance limited clinical response poses risk later long term complications including malignancy major practical clinical problem assessment compliance gluten free diet although symptoms may resolve serological antibody markers may improve multiple studies documented ongoing architectural disturbance inflammatory change continued inflammatory changes persistent risk long term complications recent immunological studies suggested peptides detected urine fecal specimens may indicative limited compliance time multiple biopsy studies demonstrated complete normalization mucosa may occur patients within initiation glutenfree diet often years may required repeated biopsies eventually show mucosal recovery mucosal healing celiac disease immune mediated disorder causes severe architectural disturbance small intestinal mucosa genetically predisposed individuals impaired absorption multiple nutrients results diarrhea weight loss develop evidence accumulated strict gluten free diet result
resource allocation irish health service based historical allocations incremental increases widely believed inequitable using three round policy delphi survey seeks explore consensus disagreement surrounding policy issues views senior health service personnel sought order determine ways improve equity resource allocation panellists provided several reasons current method resource allocation inequitable several suggestions improving equity level consensus views determined calculating percentage ratings category based series rating scales main suggestion centred around development implementation needs based resource allocation formula panellists reached high consensus favour reached low consensus feasibility potential obstacles identified included methodological difficulties insufficient resources resistance potential losers findings highlight concerns lack transparency resource allocation process openness development equitable needs based resource allocation model move becoming common internationally feasibility concerns preclude attempt begin process elsevier ireland ltd rights reserved
respiratory chemoreceptors neurons detect pco body fluids provide sensory feedback control breathing play critical role coupling pulmonary ventilation metabolic demand endothermic vertebrates birth mammals hatching birds state change placental chorioallantoic gas exchange pulmonary respiration makes acute demands neonatal lungs ventilatory control system including respiratory chemoreceptors review literature prenatal development carotid body chemoreceptors central chemoreceptors airway chemoreceptors emphasis histology histochemistry neurophysiology chemosensory cells afferents physiological genomics known general respiratory chemoreceptors develop prenatally functional immature birth hatching type respiratory chemoreceptor unique prenatal developmental time course studied date require period postnatal maturation express full adult response elsevier rights reserved
respite workers commonly care children intellectual disabilities pain common children little known factors inform pain assessment management related decisions objectives describe determine following response series pain related scenarios headache falling factors considered important assessing children pain whether children verbal ability impacts pain assessment factors considered assessment management approach participants fifty six years age female procedure measures online survey participants read responded six vignettes manipulating child verbal ability verbal nonverbal pain source results factors frequently considered assessing pain child behavior range history pain general factors vary child verbal ability indicated varied assessment management related actions range scenario discussion findings suggest factors informing pain assessment depend whether child verbal degree flexibility response pain across situations findings encouraging ensuring adequate pain assessment management knowledge specific children critical elsevier ltd rights reserved
restricted sensing actuation control represents important area research overlooked design methodologies many practical control engineering problems necessitated implement design single sensor single actuator multivariate performance variables paper novel approach proposed solution single sensor single actuator control problem performance prescribed frequency band also tailored results obtained broad band control design based formulation discrete frequency control shown single sensor single actuator control problem frequency band cast nevanlinna pick interpolation problem optimal controller obtained via convex optimization lmis even remarkable robustness issues also tackled framework numerical example provided broad band attenuation rotor blade vibration illustrate proposed design procedures isa published elsevier ltd rights reserved
results previous studies dsm dsm antisocial personality disorder aspd suggested construct etiologically multidimensional knowledge however structure genetic environmental influences aspd examined using appropriate range biometric models diagnostic interviews aspd criteria section assessed population based sample norwegian twins structured interview dsm personality disorders exploratory analyses conducted phenotypic level multivariate biometric models including independent common pathways compared single phenotypic factor found best fitting biometric model single factor common pathway model common factor heritability words genetic environmental correlations aspd criteria could accounted single common latent variable findings support validity aspd unidimensional diagnostic construct
results numerical calculations heat exchange nuclear heating detector nuclear reactors presented paper gamma radiation generated nuclear reactor fission radiative capture reactions well radioactive decay products single cell calorimeter designed application maria research reactor national centre nuclear research ncbj swierk near warsaw poland also used jules horowitz reactor jhr construction research centre cadarache france consists cylindrical sample surrounded gas layer contained cylindrical housing additional calculations performed insertion reactor within analysis modern computational fluid dynamics cfd methods used assessing important parameters example mean surface temperature mean volume temperature maximum sample calorimeter core temperature results experiment performed dedicated pile calibration bench results numerical modelling validation also included paper
revetment protective structure shoreline stony material usually natural stone concrete thickness one layer elements elements placed pattern various conditions designing implementing coastal protection structures implementation speed construction cost cause use articulated concrete block mattress acb mat acb mattresses appropriate flexibility installed different conditions slope revetments acb mat system includes filter layer allows infiltration exfiltration occur providing particle retention soil subgrade determine extent effect hydrodynamic structural non structural factors well presenting dimensionless relations design charts acb mats experimental data needed achieved appropriate laboratory scale model lambda present study effect various parameters investigated improve existing formula adding effects mattress length construction slope filter layer acb mat thickness friction coefficient accordingly new modified equation obtained adding parameters stability shifting factor stability course factor stability shape factor presented approximate respectively end six design charts presented helpful determine minimum length mattress different wave characteristics construction slope two type filter layer elsevier ltd rights reserved
review pattern recognition receptor nlrp modulators inflammatory network infection cancer autoinflammatory disorders nlrs class cytoplasmic prrs various functions ranging pathogen damage sensing modulation inflammatory signaling transcriptional control mhc related genes addition nlrs implicated preimplantation prenatal development nlrp also known rno pypaf monarch member family containing terminal pyd nbd terminal lrr region one first described nlr proteins whose role remains controversial interest toward nlrp boosted recent involvement colon cancer well protection severe infections induced yersinia pestis causative agent plague nlrp mainly expressed immune cells expression regulated response pathogen products inflammatory cytokines predicted play role negative regulator inflammatory response herein present overview nlr family summarize recent insights nlrp addressing contribution inflammatory signaling host defense carcinogenesis
reviewing recent literature role mitochondria fetal development paradoxically reveals two features importance mitochondria early developmental phases scarcity information available humans indeed available information role mitochondria development comes studies animal models necessarily strictly apply humans paper attempted collect information existing humans together data animal studies essentially presented corroboration makes clear complex interacting network energetic genetic epigenetic factors governs impact mitochondrial function early development humans complexity presumably also accounts poor understanding consequences impaired mitochondrial function prenatal development conversely impact development expression deficiencies elsevier ltd rights reserved
rgb sensors widely used various areas computer vision graphics good descriptor effectively improve performance operation article analyzes recognition performance shape features extracted multi modality source data using rgb sensors hybrid shape descriptor proposed representation objects recognition first extracted five shape features contour based images five shape features point cloud data capture global local shape characteristics object recognition performance tested category recognition instance recognition experimental results show proposed shape descriptor outperforms several common global global shape descriptors comparable partial global shape descriptors achieved best accuracies category instance recognition contribution partial features computational complexity also analyzed results indicate proposed shape features strong cues object recognition combined features boost accuracy
rhino orbito cerebral mucormycosis rare fatal invasive fungal infection occurs mostly patients immunocompromised conditions diabetes mellitus prevalence rare condition escalating due increased numbers patients diabetes hematologic malignancies organ transplantations timely diagnosis judicious treatment decisions reduce complication rates improve survival imperative nurse practitioners primary care providers adequate knowledge identifying mucormycosis initiate appropriate treatment without delay
risk analysis essential attracting investment solar projects paper measures risk variability internal rate return irr estimates uncertainty future systems prices operations costs iii revenues based energy yield irradiance electricity prices quantify risks photovoltaic concentrated photovoltaic cpv projects starting customers selling solar generated electricity fixed feed tariff fit large business customers displacing electricity loads would pay according variable market rates international comparison results provided uncertainty future systems prices causes average cpv variation irr important developer planning process resolvable negotiated system prices suppliers uncertainty future operations costs impacts irr average cpv uncertainty revenues impacts irr furthermore analysis shows overall percentage variability project irr much less percentage variability operations costs revenues two factors play system operating elsevier ltd rights reserved
rivei managers aware wood clogging mechanisms frequently trigger damage causing processes like structural damages bridges sudden channel outbursts occasionally major displacements water course successfully mitigate flood risks related transport large wood river managers need guideline accurate reliable risk assessment procedure design river sections bridges endangered clogging recent years comprehensive research dealing triggers wood clogging mechanisms bridges corresponding impacts flood risk accomplished university innsbruck large set laboratory experiments rectangular flume conducted paper provide overall view tests present findings applying logistic regression analysis available knowledge influence geometrical hydraulic wood related parameters clogging probabilities processed generalized form based experimental modeling results practice oriented guideline supports assessment flood risk induced clogging presented context two specific local structural protection measures bridge aiming significant decrease entrapment probabilities illustrated deflecting baffle installed upstream face bridge channel constriction leading change flow state corresponding increase flow velocities freeboard bridge cross section presented guideline based three step approach estimation potential entrainment transport clogging scenario bridge impact channel floodplain hydraulics specific bridge susceptible potential clogging caused entrapment allows qualitative evaluation potential entrainment upstream river segments transport toward hydraulic bottleneck quantification expected entrapment probabilities depending amount characteristics impacting consequences bridge clogging determined bridge clogging scenarios considered within hydrodynamic numerical modeling elsevier rights reserved
robot recognition tasks usually require multiple homogeneous heterogeneous sensors intrinsically generate sequential redundant storage demanding data various noise pollution thus online machine learning algorithms performing efficient sensory feature fusion become hot topic robot recognition domain paper proposes online multi kernel extreme learning machine elm assembles multiple elm classifiers optimizes kernel weights norm formulation multi kernel learning mkl problem applied feature fusion applications require incremental learning multiple sequential sensory readings performance elm tested towards four different robot recognition tasks comparing several state art online models multi kernel learning claim method achieves superior equivalent training accuracy generalization ability less training time practical suggestions also given aid effective online fusion robot sensory features
robotics teachers explore multidisciplinary formation engineering student use appropriate learning methodology enables development transversal skills educational process paper discuss new experience project based learning involving design development low cost robot manipulator six degrees freedom motivate undergraduate students robotic elements course automation control engineering mechanical engineering escola minas universidade federal ouro preto students carried activities two years key learning objectives project implementation tools detailed evaluation results decrease dropping automation control engineering show project effective students engagement motivation
robust efficient target tracking algorithms embedded moving platforms requirement many computer vision robotic applications however deployment real time system challenging even computational power modern hardware inspiration look biological lightweight solutions lightweight low powered flying insects example dragonflies pursue prey mates within cluttered natural environments deftly selecting target amidst swarms laboratory study physiology morphology dragonfly small target motion detector neurons likely underlie pursuit behaviour describe insect inspired tracking model derived data compare efficacy efficiency state art engineering models model inputs use publicly available video sequences well task specific dataset small targets embedded within natural scenes context tracking problem describe differences object statistics within video sequences general dataset model often locks small components larger objects tracking moving features input imagery includes small moving targets highly nonlinear filtering matched robustness outperforms state art trackers scenarios insect inspired tracker runs least twice speed comparison algorithms
role knowledge management knowledge reuse investigated analytically higher educational environment using nonaka takeuchi harsh models observed three dimensional environment knowledge management reuse together play key role students faculty could appropriately exploited comprehensive system built benefit students faculty wider areas respective knowledge management special benefits knowledge reuse may seen could treat knowledge reusability independent quantity along explicit tacit knowledge current model reveals analytically knowledge reusability may boost operative knowledge educational organization may sovereign reality present work may also helpful manage knowledge software reuse associated actions
rooftop rainwater harvesting among options play central role addressing water security reducing impacts environment storm annual storm runoff coefficient asrc play significant role quantification potential rooftop catchments rainwater harvesting however usually selected generic lists available literature study explores methodology procedures based one popular versatile hydrological model soil conservation service curve number scs scs variants hawkins scs hscs model hawkins michel scs mscs model michel water resour res storm water management model annual storm runoff coefficient swmm asrc heaney compares performance central ground board cgwb cgwb approach found amount rainfall rooftop catchment area mscs model yields highest rooftop runoff followed swmm asrc hscs scs cgwb however scs model close resemblance cgwb approach followed hscs model swmm asrc mscs model asrcs developed using models found mscs model highest value asrc followed swmm asrc approach hscs model scs model cgwb approach versatility models lies fact values according rooftop catchment characteristics would yield rooftop runoff therefore asrc values based sound hydrological perception empiricism models inherent capability incorporate major factors responsible runoff production rooftop urban surface characteristics initial abstraction antecedent dry weather period adwp catchments would better tool quantification rather using empirical runoff coefficients purpose
ross cheit witch hunt narrative raises number complex moral issues cheit principal purpose challenge belief society overreacted claims sexual abuse children directly indirectly cheit depth analysis broaches moral concerns pertaining integrity child abuse allegations investigations civil litigation criminal prosecution emphasis mixed motives parties involved key cases article provides overview ethical questions pertaining gathering information vulnerable individuals informed consent institutional review protection research participants use deception coercion confidentiality privacy reporting research results conflicts interest addition author discusses phenomenon whistle blowing pertains professionals ethical judgments disclosure wrongdoing misconduct author outlines key ethics related concepts applies relevant moral theory explores implications moral issues raised witch hunt narrative child sexual abuse victims perpetrators child welfare law enforcement professionals scholars researchers public large
rousseau project social contract construct conception human subjectivity political institutions would transcend saw limits liberal political theory time take starting point put forward interpretation theory general kind social cognition able preserve individual autonomy freedom alongside concerns collective welfare community whereas many seen rousseau ideas prelude communitarianism authoritarianism instead see project articulating alternative model moral cognitivist reasoning order provide framework interpretation propose reading conception general theory collective intentionality social ontology end consideration interpretation general provide satisfying understanding political practical rationality contemporary debates republicanism liberalism
routing algorithm design chip networks ocns become increasingly challenging due high levels integration complexity modern systems chip socs inherent unreliability components embedded oversized blocks fine grained voltage frequency islands vfis management among others raise several challenges ocns network topologies become irregular asymmetric making circular route dependencies lead deadlock hard detect routing algorithms lack strong load balancing properties often saturate prematurely order address aforementioned deadlock load balancing problems propose traffic balancing oblivious routing tbor algorithm two phase routing algorithm consisting construction weighted acyclic channel dependency graph cdg ocn efficiently maximize available resource utilization channel ordering across turn models keep underlying cdg cycle free guarantee deadlock freedom using one turn models channel bandwidth utilization traffic balancing achieved static virtual channel allocation according residual bandwidth healthy links addition introduce work two schemes different granularity fault detection analysis guaranteeing order packet delivery assigning unique path flow extensive experiments demonstrate proposed routing methodology outperforms previous algorithms
rule based people strive conform moral norm outcome based people hand adjust behavior concrete consequences acts argue categorization mind set may also informative comes explaining effects good bad moral examples moral behavior observer test play dictator game dictators observed prosocial antisocial third party actions different domain consequences actions affected dictator receiver identically hypothesized makes unnecessary outcome minded dictator intervene correctively influences rule minded dictator follow example aligning behavior line hypothesis find rule minded dictators reacted example set others however asymmetrically incited moral transgressions left uninspired praiseworthy examples findings call precaution applying policy measures based informing people prosocial antisocial behavior especially cultures moral focus rules elsevier inc rights reserved
runoff one main sources contamination urban areas since water transport pollutants many different media among hydrocarbons generated vehicles especially significant relevance premise study geotextiles used water purification layers within pervious pavement structures becomes crucial issue since fabrics proved suitable environment development biofilms groups microorganisms capable reducing presence hydrocarbons reason paper proposes first test assess capacity ten different geotextiles immersing culture medium prepared favour growth microbial community results showed major importance geotextile thickness generation biomass relationship manufacturing process fabric either heat sealing needle punching consequently second test developed measure mechanical behaviour geotextile type buried microbially active soil different conditions comparison exposed control samples revealed maintenance strength related properties geotextiles presence microorganisms elsevier ltd rights reserved
rupture patellar tendon uncommon injury requires acute surgical repair restore function knee multiple techniques repair described literature complications repair techniques include rerupture extensor lag caused gap formation site repair thus many surgeons suggested augmenting standard repair several methods augmentation described disadvantages purpose article present case series six patients acute patella tendon ruptures treated novel procedure using strong sutures method eight strands four strong sutures run within tendon patellar site combination suture button figure eight pattern techniques used avoiding stress concentration optimal tension applied suture patella might positioned original placement sutures secured onto tibia postoperatively mean follow months range months patients stable knee mean flexion degrees range degrees without extension lag improvement international knee documentation committee score range excellent outcome noted patients average postoperative lysholm score range average kujala score range patients recovered near normal strength stability patellar tendon well restoration function operation augmentation technique offers distinct advantage previous augmentation methods materials may especially useful managing patellar tendon rupture caused rheumatoid arthritis systemic conditions reasons recommend procedure acute patellar tendon ruptures
rural transit projects often small scope numerous geographically dispersed management projects challenging limited resources unique risk factors lack construction management expertise without effective construction management strategies unlikely rural transit projects optimally planned controlled possibly resulting delays cost overruns rework injuries poor quality paper presents results comprehensive desk scan survey case studies focused identifying specific construction management challenges effective practices unique rural projects obtained responses states departments transportation two canadian provinces survey findings validated interviews representatives seven rural case study projects results indicate primary issues facing rural transit projects include documentation issues staffing remote location issues small contractor issues communication issues local environmental issues counter measures identified issues agency interviews described paper provide first targeted resource rural construction management practices research community benefits study increased understanding inherent difference construction management practices large urban small rural construction projects american society civil engineers
ruxolitinib approved therapy myelofibrosis however use patients myeloproliferative neoplasms mpn participating clinical studies poorly described reviewed medical records patients others treated ruxolitinib center clinical study year approval patients advanced features refractory multiple therapies ruxolitinib effective reducing splenomegaly response rate constitutional symptoms response rate controlled blood counts patients polycythemia thrombocythemia effective patients non classic mpns ruxolitinib active therapy patients previously treated jak inhibitor safely combined hypomethylating agents patients elevated blasts median overall survival months patients transformed acute leukemia use combination active agents explored clinical studies
ruxolitinib therapy approved indication myelofibrosis myeloproliferative neoplasm associated progressive bone marrow fibrosis extramedullary hematopoiesis although pivotal phase comfort studies included patients intermediate high risk indication includes patients intermediate high risk disease data recent nonrandomized studies confirm benefits ruxolitinib established comfort studies terms spleen size reduction symptom improvement also extend patients intermediate risk tend less advanced disease patients higher risk given disease modifying potential ruxolitinib therapy timely initiation ruxolitinib therapy may improve patients current clinical status also lead better long term outcomes decision whether initiate ruxolitinib treatment based expected benefit risk ratio patient specifically considering potential adverse effects
member family binding proteins regulates several cellular processes including involved signaling cardiac skeletal muscle function alzheimer disease brain overexpressed gives rise disease pathologies making potential therapeutic target angstrom resolution crystal structure solved compared structures proteins notably highly homologous family member implicated progression malignant melanoma observed structural differences versus provide insights regarding target proteinbinding specificity targeting two proteins human diseases using structure based drug design approaches
safe potable water essential good health worldwide school aged children especially developing countries suffering various water borne diseases study drinking water supplies primary school children monitored magura district bangladesh ensure safe potable water apha standard analytical methods applied determining physicochemical parameters water samples determination essential physicochemical parameters samples collected randomly selected tube wells primary schools magura metal contents especially arsenic iron manganese water samples analyzed atomic absorption spectroscopy range physicochemical parameters found water samples follows electrical conductivity chloride hardness caco total dissolved solids level metals tube well water samples follows drinking water parameters magura district meet requirement world health organization drinking water quality guideline drinking water quality standards bangladesh
safe school environments essential healthy development yet schools near large scale livestock facilities emit air pollution hydrogen sulfide decomposing manure indicator livestock related air pollution measured outdoor concentrations three public middle schools near livestock facilities north carolina used circular graphs relate detection wind direction geospatial distributions nearby livestock barns also used logistic linear regression model relation upwind distance weighted livestock barn area circular graphs suggested association upwind livestock barns detection log odds detection per increased upwind weighted swine barn area school beta coefficient beta school beta upwind weighted poultry barn area school beta stronger associations periods atmospheric stability atmospheric instability school stable beta school unstable beta concentration also increased linearly upwind swine barn area greater increases stable atmospheric conditions stable beta parts per billion unstable beta site migration pollutants industrial livestock operations decrease air quality nearby schools
safety reliability major issues asdex upgrade aug pulsed power supply systems avoid long downtimes experimental campaign fault prone components identified treated early becomes even important due aug participation eurofusion medium sized tokamak mst program operating equipment years old adds additional complications contribution describes one example year old flywheel generator aug identified fault prone pre emptively upgraded new drive converter integrated control challenging adapt modern converter originally designed wind turbines toward drive system flywheel motor generator system identify layout controller control parameters accurate modeling comprehensive simulations performed effort paid commissioning measuring results verified calculated design values finally system shows good performance aug plasma experiments elsevier rights reserved
saikosaponin class native compound numerous biological activities may exert protective effect postmenopausal bone loss however remains unknown whether regulates osteogenic differentiation bone marrow stromal cells bmscs treatment prevention osteoporosis study bmscs treated various concentrations stimulate osteogenic differentiation day period additionally canonical ovariectomized ovx mouse model used evaluate effect month treatment preventing postmenopausal osteoporosis vitro found promotes alkaline phosphatase activity staining alizarin red assay stimulated expression osteogenic markers runt related transcription factor runx osterix osteopontin osteocalcin ocn bmscs vivo trabecular number trabecular thickness trabecular bone mineral density distal femoral metaphysis significantly increased ovx mice treated intraperitoneally months compared ovx mice treated moreover expression runx ocn ovx mice significantly increased ovx mice finally found activated wnt beta catenin pathway expression several downstream genes including cell factor lymphoid enhancer factor inhibition wnt beta catenin pathway dickkopf related protein blocked positive role osteogenesis therefore promoted osteogenic differentiation bmscs wnt beta catenin signaling
saliency detection widely studied predict human fixations various applications computer vision image processing saliency detection argue paper state art high efficiency video coding hevc standard used generate useful features compressed domain therefore paper proposes learn video saliency model regard hevc features first establish eye tracking database video saliency detection downloaded https github com remega video database statistical analysis eye tracking database find human fixations tend fall regions large valued hevc features splitting depth bit allocation motion vector addition three observations obtained analysis eye tracking database accordingly several features hevc domain proposed basis splitting depth bit allocation next kind support vector machine learned integrate hevc features together video saliency detection since almost video data stored compressed form method able avoid computational cost decoding storage cost raw data importantly experimental results show proposed method superior stateof art saliency detection methods either compressed uncompressed domain
salient object detection experienced several decades active popular topic computer vision although large amount detection algorithms proposed obtained saliency maps still satisfying enough end proposed simple novel supervised algorithm detect pure background saliency map using conditional random fields crf saliency cues existing crf approaches set probabilistic graphical models pixel wise eight neighborhood grid shaped graph superpixel level graph handling simplify model also promote performance due superpixel level two ring pseudo background neighborhood system intuitive easy interpret result saliency maps generated proposed model relatively pure background regions extensive experimental evaluations six benchmark datasets pixel wise ground truths validated robustness effectiveness proposed saliency model elsevier rights reserved
satellite radio location data adult male pacific walruses odobenus rosmarus divergens used estimate haul fidelity broadly describe seasonal foraging distributions determine approximate timing autumn migration bristol bay alaska data collected intermittently primarily period may october transmitter longevity ranged less day days median four tagging sites haul outs commonly used bay spring autumn mean fidelity defined chance animal return area previously hauled however small sample sizes precluded comparisons fidelity among years among haul outs season tagged animals migrated bay spring early autumn combined monthly locations suggest foraging occurred primarily southern eastern areas bay spring gradually shifted towards northwestern areas late autumn winter ninety eight percent water locations waters deep account study area animals migrated bay late autumn winter others remained within bay throughout year making long range migrations departed bay november december
saudi arabia facing issues completing construction projects time budget documented public construction projects delayed case study performed university campus northern saudi arabia identifying major causes project delays university experiencing delays delay factors gathered university projects director university delay factors compared delay factors experienced saudi construction projects identified performing literature research comparison identified nine causes delays studies documented study also proposes solution minimize nine major delay factors literature research identified one construction management method performance information procurement system pips documented multiple times ability improve project performance minimize delays authors published elsevier ltd
scheduling generation units modern power markets one important tasks independent system operators iso ensure secure economical operation power systems isos solve security constrained unit commitment scuc problem scuc complex large scale optimization problem addition uncertainties imposed wind generators variable loads add complexity stochastic scuc one important problems scheduling generation units considers different power system uncertainties considerable amount previous works demonstrates efficacy decomposition techniques benders decomposition stochastic scuc solving problem even decomposition techniques large scale systems multiple uncertainties time consuming major part stochastic scuc constraints belongs network security paper presents method cumulants used detect eliminate inactive network constraints solving process result method reduces number network security constraints decreases simulation time considerably implementing proposed method six bus test system modified ieee bus system demonstrates efficiency accuracy
schizophrenia bipolar disorder serious neuropsychiatric disorders uncertain etiology recent studies indicate immune activation may contribute etiopathogenesis disorders numerous studies animal models indicate mucosal microbiome may influence cognition behavior altering functioning immune system thus likely microbiome plays role human psychiatric disorders study immune alterations microbiome schizophrenia bipolar disorder infancy two recent investigations oro pharyngeal microbiota schizophrenia found differences cases controls studies found increased gastrointestinal inflammation schizophrenia bipolar disorder based measures microbial translocation several studies also found association receipt antibiotics increased incidence psychiatric disorders perhaps due alterations microbiome studies characterize intestinal microbiome individuals disorders progress ultimate test role microbiome immune mediated pathology schizophrenia bipolar disorder come clinical trials therapeutic agents alter gut microbiota gastrointestinal inflammation successful development modalities would represent novel strategy prevent treat serious psychiatric disorders elsevier inc rights reserved
schizophrenia associated deficits cortical plasticity affect sensory brain regions lead impaired cognitive performance examined underlying neural mechanisms auditory plasticity deficits using combined behavioural neurophysiological assessment along neuropharmacological manipulation targeted methyl aspartate type glutamate receptor nmdar cortical plasticity assessed cohort schizophrenia schizoaffective patients relative healthy control subjects using fixed reference tone auditory plasticity task second cohort schizophrenia schizoaffective patients healthy controls event related potential event related time frequency measures auditory dysfunction assessed administration nmdar agonist serine mismatch negativity used functional read auditory level function clinical trials registration numbers nct nct schizophrenia schizoaffective patients showed significantly reduced auditory plasticity versus healthy controls correlated measures cognitive occupational social dysfunction event related potential time frequency analyses patients showed highly significant reductions sensory reflected underlying impairments theta responses along reduced theta beta power modulation retention motor preparation intervals repeated administration serine led intercorrelated improvements auditory plasticity theta frequency response iii mismatch negativity generation trained versus untrained tones schizophrenia schizoaffective patients show highly significant deficits auditory plasticity contribute cognitive occupational social dysfunction serine studies suggest first nmdar dysfunction may contribute underlying cortical plasticity deficits second repeated nmdar agonist administration may enhance cortical plasticity schizophrenia
schlieren shadowgraph techniques used around world imaging measuring phenomena transparent media optical methods originated long ago parallel telescopes microscopes although might seem little new could expected timescale years fact several important things happened reviewed digital revolution transformative effect replacing clumsy photographic film methods excellent though expensive high speed video cameras making digital correlation processing shadow schlieren images routine providing entirely new synthetic schlieren technique attracted lot attention background oriented schlieren bos several aspects modern schlieren shadowgraphy depend upon laptop scale computer processing images using imagecapable language matlab bos shock wave tracking schlieren velocimetry synthetic streak schlieren straightforward quantitative density measurements flows recent developments empowered digital computational capability
scholars wide range disciplines perspectives sought unravel high complexities sustainability mature understanding sustainability management requires studies adopt multidisciplinary systemic lens capable appreciating interconnectivity economic political social ecological issues across temporal spatial dimensions yet field systems thinking context sustainability management research disparate benefit comprehensive review order assimilate current fragmented body research identify promising research directions address gap conducted review systems thinking sustainability management literature including articles review first present descriptives show emerging body work rapidly growing since found percent articles published two transdisciplinary journals demonstrating systemic approach yet prevalent mainstream management journals second identify describe core theoretical concepts systems thinking found literature including interconnections feedbacks adaptive capacity emergence self organization third findings show number research themes including behavioral change leadership innovation industrial ecology social ecological systems transitions management paradigm shifts sustainability education finally offer cross scale integrated framework findings conclude identifying number promising research opportunities elsevier ltd rights reserved
scientific research often fails relevance impact scientists engage policy makers influencers process identifying information needs generating high priority questions address scholarship policy gap developed model strategic science research approach involves working policy makers influencers craft research questions answer important timely policy related questions goal create tighter links research policy ensure findings communicated efficiently change agents best positioned apply research policy debates article lay model strategic science describe approach may help advance policy research action eating disorders
scientific workflows orchestrate execution complex experiments frequently using distributed computing platforms meta workflows represent emerging type workflows aim reuse existing workflows potentially different workflow systems achieve complex experimentation minimizing workflow design testing efforts workflow interoperability plays profound role achieving objective paper focused fostering interoperability across meta workflows combine workflows different workflow systems diverse scientific domains achieved formalizing definitions meta workflow different types standardize data structures used describe workflows published shared via public repositories paper also includes thorough formalization two workflow interoperability approaches based formal description coarse grained fine grained workflow interoperability approach paper presents case study astrophysics successfully demonstrates use concepts meta workflows workflow interoperability within scientific simulation platform
sdn network architecture emerged top existing technologies knowledge defining controller software program sdn made strong connection networking software engineering traditionally network programs vendor specific embedded hardware switches routers sdn focuses isolation control forwarding data planes however complete sdn network many areas cpu memory hardware bandwidth software paper propose extending sdn architecture propose isolation layers goal improving overall network design flexible architecture support future evolution changes without need significantly change original components modules
seafood fraud often involving substitution one species another attracted much attention prevalent worldwide whilst dna analysis helped combat type fraud methods currently use time consuming require sophisticated equipment highly trained personnel work describes development new real time pcr taqman assay detection ling molva molva seafood products purpose specific primers minor groove binding mgb taqman probe designed amplify region cyt gene efficiency specificity cross reactivity assays showed statistically significant differences average value obtained molva molva dna average non target species dna even closely related species molva dypterygia proposed methodology validated commercial samples elsevier ltd rights reserved
search based software engineering sbse solutions still scalable enough handle high dimensional objectives space majority existing work treats software engineering problems single objective point view main goal maximize minimize one two objectives however software engineering problems naturally complex many conflicting objectives need optimized software refactoring one problems involving finding compromise several quality attributes improve quality system preserving behavior end propose novel representation refactoring problem many objective one every quality attribute improve considered independent objective optimized approach based recent nsga iii algorithm refactoring solutions evaluated using set distinct objectives evaluated approach one industrial project seven open source systems compared findings several many objective techniques ibea moea grea dbea eps existing multi objective approach mono objective technique existing refactoring technique based heuristic search statistical analysis experiments runs shows efficiency approach
searching effective biomarkers one challenging tasks research field autism spectrum disorder asd magnetic resonance imaging mri provides non invasive powerful tool investigating changes structure function maturation connectivity metabolism brain children asd review recent mri studies young children asd aiming provide candidate biomarkers diagnosis childhood asd review covers structural imaging methods diffusion tensor imaging resting state functional mri magnetic resonance spectroscopy future advances neuroimaging techniques well cross disciplinary studies large scale collaborations needed integrated approach linking neuroimaging genetics phenotypic data allow discovery new effective biomarkers
seasonal affective disorder sad condition seasonal mood changes characterized recurrent depression autumn winter spontaneously remits spring summer evidence suggested circadian gene variants contribute pathogenesis sad study investigated polymorphisms clock arntl npas genes relation seasonal variation healthy young adults seasonal variations assessed seasonality pattern assessment questionnaire prevalence sad winter type summer type significant difference found groups genotype distribution arntl npas allele clock significantly frequent seasonals sad subsyndromal sad compared non seasonals odds ratio confidence interval global seasonality score significantly different among genotypes clock among genotypes arntl npas however statistical difference observed body weight appetite subscales among genotypes arntl body weight subscale among genotypes npas synergistic interaction clock arntl seasonality knowledge study first reveal association clock gene seasonal variations mood behavior korean population although confirm previous findings association sad arntl npas genes genes may influence seasonal variations metabolic factors body weight appetite interaction clock arntl genes contributes susceptibility sad
seasonal affective disorder sad defined subtype mood disorders dsm characterized seasonal onset sad proposed related seasonal changes naturally occurring light use bright light therapy depressive symptoms shown reduce placebo controlled trials cognitive behavioral therapy also demonstrated effective sad review article aims focus psychopharmacological treatment options sad according clinical trial results first line treatment options seem sertraline fluoxetine well tolerated patients evidence antidepressants bupropion might effective well although clinical trials shown antidepressants may benefit recent review concluded enough evidence support use agents treatment sad yet moreover studies still needed evaluate effectiveness treatment options propranolol melatonin hypericum etc addition proposed treatments patients seasonal depressive symptoms thoroughly evaluated cues bipolarity treatment planned accordingly
seasonal affective disorder sad winter type seasonal pattern recurrent major depressive episodes commonly occurring autumn winter remitting spring summer syndrome well known three decades light treatment treatment first choice paper overview presented present insights sad description syndrome etiology treatment options mentioned apart light treatment medication psychotherapy treatment options predictable repetitive nature syndrome makes possible discuss preventive treatment options furthermore critical views concept sad distinct diagnosis discussed
secret sharing schemes divide secret among multiple participants authorized subsets parties reconstruct show secretly embedded trapdoor universal protection attack embedded secret sharing schemes employ enough randomness give attacker overwhelming advantage access secret case ideal schemes coalition participants within least one attacker succeed attack case non ideal schemes attacker knowledge enough reveal secret exemplify attack shamir threshold scheme well known used secret sharing scheme finally consider prevention techniques proposed attack john wiley sons ltd
security major concern computing environments one way achieve security deploy secure operating system trusted actually secure resources resist vulnerabilities attacks effectively paper contribution twofold firstly critically analyze host vulnerabilities modern desktop oss group existing approaches provide easy concise view different security models adapted widely used oss comparison several oss regarding structure architecture mode working security models also form part paper secondly use current usage statistics windows linux mac oss predict future forecast help designers developers users different oss prepare upcoming years accordingly
security essential wide wireless sensor network wsn deployments internet things iot however resource constrained nature sensors severely restricts cryptographic algorithms protocols used platforms restrictions apply especially authenticated key agreement aka protocols bootstrapping keys authorized nodes traditional networks schemes involve transmission quite large certificates execution memory processing intensive cryptographic algorithms suitable wsns whereas lightweight wsn oriented schemes also exist focus small deployments key escrow possible fully trusted authority knows private keys nodes aiming identify aka solutions suitable iot scenario article assess lightweight escrow free schemes evaluating security performance terms processing time energy consumption telosb platform besides proving efficient schemes actually flawed show combination smqv strengthened menezes vanstone implicit certificates leads secure lightweight aka scheme elsevier rights reserved
sediment transport important aspect soil erosion sediment transport capacity key establishing process based erosion models lot studies exist determined overland flow however studies conducted determine loess sediments steep slopes experimental data region thus needed objectives study formulate new equations describe evaluate suitability equations loess sediments steep slopes slope gradients study ranged flow discharges per unit width varied results showed increased power function flow discharge slope gradient nash sut liffe model efficiency nse sensitive flow discharge slope gradient increased power function mean flow velocity satisfied predict nse shear stress nse also good predictor stream power nse better predictor shear stress however unit stream power good predictor estimate study nse findings offer new approach predicting loess sediments steep slopes elsevier rights reserved
selecting appropriate mid model critical high efficiency model transition data migration relational databases nosql databases explore problem uniform mid model design used model transition data migration relational databases nosql databases suggested approach proposes complete process use data features query features generate mid model predefined strategy transfer mid model physical model destination database establishing mapping migrate data source databases destination databases
self awareness often impaired acquired brain injury abi hampers rehabilitation general unrealistic reports patients functioning poor motivation compliance treatment evaluated self awareness treatment part treatment protocol executive dysfunction spikman boelen lamberts brouwer fasotti total patients included aged suffering non progressive abi minimum time post onset months self awareness measured comparing patient dysexecutive questionnaire wilson alderman burgess emslie evans score independent emotion recognition associated self awareness influences effect rehabilitation treatment assessed function using facial expressions emotion stimuli tests young perrett calder sprengelmeyer ekman results showed patients experimental treatment group better self awareness training control patients moreover results confirmed level self awareness treatment related emotion recognition hence self awareness improve neuropsychological treatment fostering self monitoring since neuropsychological treatment involves social learning impairments social cognition taken account starting treatment
self powered triboelectric nanosensor tens attracted increasing attention recent years due independent sustainable operations without external power source paper demonstrate newly designed fully packaged liquid solid tens based friction polytetrafluoroethylene ptfe filtration membranes water dependencies output performance water based tens water cylinder volume ratio vibration frequency amplitude using fluid mechanics analysis demonstrated modifying ptfe filtration membrane dopamine tens used dopamine sensor high selectivity sensitivity detection limit linear range besides mixing organics ethanol decrease water polarity tens used sensor detection ethanol concentration water fast response room temperature compared existing solid solid triboelectrication based tens fully packaged liquid solid triboelectrication based tens portable easily fabricated potential application detecting toxic pollutants water higher sensitivity
self purification frequent phenomenon suceava river homonymous city self purification documented total nitrogen total phosphorus time interval monthly average self purification percentages sampling points upstream downstream city main factors contribute observed self purification iron rich streamwater sedimentary biological retention treatment different contaminated waters hydraulic jumps seasonal variations average maximum monthly self purification percentages water pollution higher self purification process stronger
semantic technologies currently spreading across several application domains reliable consistent mean address challenges related organization manipulation visualization exchange data knowledge different roles actually played techniques depending application domain timing constraints distributed nature applications paper provides overview roles played semantic technologies domain smart grids smart environments particular focus changes brought technologies adopted architectures programming techniques tools motivations driving adoption semantics different strictly intertwined fields introduced using strong application driven perspective two real world case studies smart grids smart environments presented exemplify roles covered technologies changes fostered software engineering processes learned lessons distilled future adoption scenarios discussed elsevier rights reserved
semiconductor photocatalysis harvasting utilizaing solar energy solve worldwide environmental pollution energy shortage attracted flourishing interest complete understanding structure function relationships well defined model catalysts essential better understanding real world photocatalysis well rationally design photocatalysts well defined nanbo crystals successful synthesized via facile hydrothermal method systematically characterzation performed xrd raman sem bet specific surface area analyzer druv vis results xrd raman show prepared samples pure orthorhombic nanbo nanbo different morphology possess various mainly exposed facets basis statistical sem measurements presents shape evolution nanbo shown dependent reaction time nanowires mixture nanowires microcubes finally microcubes realized morphology control systhesis nanbo possible growth mechanism proposed combined previous study highlighting crucial role photocatalytic performance prepared nanbo crystals assessed towards aqueous methyl bule illumination compared commercial nanbo powders druv vis evidenced absorption edge nanbo nanowires blue shifted due quantum size effect results show photoreactivity morphology dependent bet specific surface area normalized reaction rate constants follow order nanbo nanowires nanbo microcubes commercial nanbo exposed facets play crucial role determining observed photocatalytic activity
semistability property whereby solutions dynamical system converge lyapunov stable equilibrium point determined system initial conditions extend theory semistability class first order evolution variational inequalities study finite time semistability results lyapunov based obtained without assumptions sign definiteness lyapunov function results supported examples unilateral mechanics electrical circuits involving nonsmooth elements coulomb friction forces diodes
sendai virus sev enveloped nonsegmented negative strand rna virus belongs genus respirovirus paramyxoviridae family model pathogen sev extensively studied define basic biochemical molecular biologic properties paramyxoviruses addition sev infected host cells widely employed uncover mechanism innate immune response identify proteins involved sev infection process sev induced innate immune response process system wide evaluations sev host interactions performed cdna microarray sirna screening phosphoproteomic analysis suggested multiple signaling pathways involved sev infection process study sev host interaction global quantitative proteomic analysis performed sev infected hek cells total host proteins quantified proteins differentially regulated bioinformatics analysis indicated regulated proteins mainly involved interferon type ifn signaling pathway defense response virus suggesting processes play roles sev infection rnai based functional studies indicated regulated proteins tripartite motif trim trim affect sev induced ifn production data provided comprehensive view host cell response sev identified host proteins involved sev infection process sev induced innate immune response process
sensitive skin frequently mentioned cosmetic complaint addition biomimetic neuromediator recently appeared promising new way cure skin care product problems study aimed assess inhibitory effect biomimetic lipopeptide derived proopiomelanocortin bpomc capsaicin induced sensory irritation human volunteers also compare protective effect well known anti irritant strontium chloride effect test compound studied selected healthy volunteers sensitive skin accordance double blind vehicle controlled protocol day day group applied test compound bpomc strontium chloride one wing nose corresponding placebo vehicle side twice daily days acute skin irritation induced capsaicin solution quantified using clinical stinging test assessments following application capsaicin solution sensory irritation evaluated using point numeric scale sensations perceived treatment days calculated two zones test materials vehicle ultimately percentage variation sample placebo also inhibitory effect bpomc compared strontium chloride reported clinical results showed two weeks treatment levels skin comfort reported group treated bpomc significantly higher obtained placebo group inhibitory effect bpomc higher strontium chloride results present study support hypothesis biomimetic peptides may effective sensitive skin
sensorimotor adaptation requires integration internal models motor control feedback external environment highlighted brudner kethidi graeupner ivry taylor neurophysiol feedback characteristics error outcome based well temporal constraints impact motor learning adaptation strategies findings provide novel insight underlying components motor control applied future clinical experimental research motor processes
sequential photoinduced energy transfer followed electron transfer formation charge separated states primary events natural photosynthesis demonstrated newly synthesized multichromophoric covalently linked triad pdi sipc triad comprises perylenediimide pdi primarily fulfils antenna electron acceptor functionalities silicon phthalocyanine sipc electron donor fulleropyrrolidine second electron acceptor multi step convergent synthetic procedure developed produced good yields triad control dyads pdi sipc sipc structures geometries newly synthesized donor acceptor systems established spectral computational electrochemical studies reference appropriate control compounds ultrafast energy transfer pdi sipc case pdi sipc pdi sipc witnessed energy level diagram established spectral electrochemical data suggested formation two types charge separated states pdi sipc pdi sipc sipc triad generation latter energetically favorable however photochemical studies involving femtosecond transient spectroscopy revealed formation pdi sipc major charge separated product observation may rationalized terms closer spatial proximity sipc compared pdi triad charge separated state persisted nanoseconds prior populating sipc state charge recombination
serious environmental management games improve understanding practical environmental sustainability challenges offering opportunities obtain first hand experiences may otherwise costly difficult dangerous reproduce reality game based learning gbl found increase soft skills critical thinking creative problem solving teamwork well improve cognitive development learning retention social learning important future environmental researchers professionals environmental management games applied educational settings promote awareness sustainable resource planning management among citizens increasingly exposed products information age paper provides overview game based learning state serious games environmental management offering insight potential effective tools facilitating environmental education sgs shown possess numerous qualities connected improved learning experiences cognitive development research must continue study sgs efficacy shortcomings found games reviewed evaluate explain pedagogical foundation many hard implement accessible methods employed determining effectiveness sgs vary greatly among environmental studies necessitating standardized methodology reduce disparities testing procedures furthermore centralized source effectively online database sgs needed locating obtaining information pertaining available environmental games appropriate applications elsevier ltd rights reserved
serotonin plays key role mood affect dysfunction serotonin system linked depression humans animal models depression appears prior coincident overt symptoms alzheimer disease patients experts consider risk factor development addition prevalent women also show increased incidence depression indeed proposed mechanisms underlying depression overlap mechanisms thought hasten women undergo ovarian failure cessation ovarian steroid production middle age postmenopausal period correlates increase onset depression laboratory examined many actions ovarian steroids serotonin system non human primates using rhesus macaque model surgical menopause short long term estradiol estradiol plus progesterone replacement therapy mini review present brief synopsis relevant literature concerning depression serotonin also present data serotonin neuron viability involvement caspase independent pathway apoptosis inducing factor serotonin neuron viability well gene expression related neurodegeneration neuron viability serotonin neurons adult aged surgical menopausal macaques show ovarian steroids particularly crucial serotonin neuron function health absence serotonin neurons endangered deteriorating toward apoptosis possibility scenario may proceed accompany postmenopausal women seems likely
serum testosterone potential marker distinguish indolent aggressive prostate cancer pca present study aimed investigate whether low levels total serum testosterone diagnosis associated aggressive pca poor clinical outcomes total non hispanic caucasian men previously untreated pca recruited university texas anderson cancer center houston usa patients categorized three groups based total serum testosterone levels according clinical guidelines low pca aggressiveness low intermediate high risk metastatic compared using multinomial logistic regression rates disease progression mortality cause pca specific mortality compared using multivariate cox proportional hazards model testosterone levels significantly decreased pca aggressiveness increased compared normal testosterone group low testosterone group fold fold fold increased risks intermediate risk high risk metastatic pca respectively furthermore low levels testosterone significantly associated fold increased risk pca specific mortality results present study indicate low levels total serum testosterone diagnosis associated aggressive pca predict poor pca specific survival
service recommender systems provide recommendations different users based ratings rankings without considering preference individual user ratings based single criteria service ignoring multiple aspects big data also affects recommender systems issues like scalability inefficiency proposed system enhances existing recommendations systems generates recommendations based categorical preferences present user matching feedback comments past users system semantically analyzes users feedback distinguishes positive negative preferences eliminate unnecessary reviews users boosts system accuracy approximate exact similarity preferences present past users computed thus recommendations generated using sbsr algorithm improve performance scalability efficiency big data environment sbsr ported distributed computing platform hadoop
several applications shape modeling exploration require identification extraction shape part matching sketch present customcut demand part extraction algorithm given sketched query customcut automatically retrieves partially matching shapes database identifies region optimally matching query shape extracts region produce customized part used various modeling applications contrast earlier work sketch based retrieval predefined parts approach extract arbitrary parts input shapes rely prior segmentation semantic components method based novel data structure fast retrieval partial matches randomized compound graph built multi view shape projections also employ coarse fine strategy progressively refine part boundaries level individual faces experimental results indicate approach provides intuitive easy means extract customized parts shape database significantly expands design space user demonstrate several applications method shape design exploration
several infectious agents appear provide proliferative signal antigen drive could implicated pathogenesis various type non hodgkin lymphoma nhl classical model infection driven lymphoproliferative disorder helicobacter pyloriinduced gastric malt lymphoma antibiotic therapy allows eradication infectious agent clonal cell expansion following footsteps example several retrospective studies found correlation pathogens cell lymphomas adding new relevant information pathogenesis laying groundwork chemotherapy free treatments although clear association found infectious agents follicular lymphoma growing number biological clinical observations suggests interaction physiological pathological microbial populations also subtype lymphoma last years epidemiological studies investigating association known risk factors found potential correlation viral bacterial infections moreover recent findings stimulation clones support importance microbial exposure lymphomagenesis disease progression following review make attempt find tangible evidence role either physiological pathological exogenous microbial species pathogenesis try integrate findings coming epidemiological biological interventional studies define future novel treatment prevention strategies
several legged robots developed recent years proved effective transportation system uneven terrain particular quadruped robots regarded new trend robotics due superior gait stability robustness disturbances recently many robotics researchers making best efforts improve locomotion speed well stability robustness quadruped robots high speed locomotion creates various challenges development actuators mechanical design control algorithms robot paper linear actuation system high speed locomotion quadruped robot introduced proposed actuator designed based principle brushed direct current electric motor systems minimal impedance improved power capacity actuator designed dual layers cores aligned parallel permanent magnets mechanical electrical properties actuation system back drivability controllability response time verified experimental results robotic leg rear leg cheetah like robot designed proposed actuator experimental results trajectory tracking performance presented
several models studies related tensile strength materials proposed literature size length component taken important factor studying specimens failure behaviour important model developed basis cumulative damage approach three parameter extension birnbaum saunders fatigue model incorporates size specimen additional variable model strong competitor commonly used weibull model stands better traditional models incorporate size effect paper considers two cumulative damage models checks compatibility real dataset compares recent toolkits finally recommends model appears appropriate one throughout study bayesian based markov chain monte carlo simulation
several urological nonurological conditions contribute onset lower urinary tract symptoms luts including benign prostatic hyperplasia bph one main underlying causes male patients six pharmacological classes adrenoceptor blockers abs alpha reductase inhibitors aris phytotherapeutics antimuscarinics ams beta adrenoceptor agonists phosphodiesterase type inhibitors pdeis available alone combination treatment male luts aim review summarize latest evidence combination medical treatments male patients luts bph standard combinations include ari patients increased prostate volume risk bph progression pdei patients concomitant erectile dysfunction beta agonist patients persistent storage symptoms risk acute urinary retention possible multidrug treatments proposed preliminary studies randomized controlled trials needed determine whether putative strategies eventually considered new standard patients luts bph possibility tailoring bph treatment according different patient characteristics expectations using two drugs seems promising path field luts bph management however physicians consider risk increasing costs without proven long term efficacy combination treatments
severe plastic deformation methods equal channel angular pressing ecap high pressure torsion hpt constrained groove pressing cgp increased importance due superior mechanical properties evolution nanostructured grains build besides severe shot peening using severe plastic deformation method recent years applied converting microstructure nanostructure surface enhancement fatigue fretting fatigue corrosion strength materials also altering surface microstructure gathers much interest severe shot peening application study severe shot peening different almen intensities performed commercially pure titanium grade specimens surfaces investigated according almen intensity plastic deformation rate also mechanical properties hardness elastic modulus investigated performing nanoindentation tests results shown work hardened layer approximately nanograin size distributions much higher nanohardness elastic modulus compared inside bulk material elsevier ltd rights reserved
sex steroid hormones inflammatory biomarkers associated development progression chronic diseases interrelationship relatively uncharacterized examined association sex hormones sex hormone binding globulin shbg biomarkers inflammation reactive protein crp white blood cell wbc count study included data adult men national health nutrition examination survey geometric means confidence intervals estimated separately crp wbc concentrations sex steroid hormones shbg using weighted linear regression models higher concentrations total slope per one quintile concentration trend calculated free slope trend testosterone statistically significantly associated lower concentrations crp wbc count men bottom quintile total testosterone might considered clinically low testosterone likely elevated crp compared men top four quintiles total calculated free estradiol positively associated crp total slope trend free slope trend wbc total slope trend free slope trend concentrations shbg concentrations inversely associated wbc count slope trend crp cross sectional findings consistent hypothesis higher androgen lower oestrogen concentrations may anti inflammatory effect men
shade coffee certification programs aim conserve forest prevent forest degradation attracted increasing amount attention however programs impact forest degradation remains unclear absence empirical evidence addition heated debate whether certification programs create incentive producers expand coffee growing areas may accelerate forest degradation surrounding natural forest study conducted ethiopia aimed evaluate impact shade coffee certification program forest degradation additionally provide empirical evidence debate examined spillover effects certification surrounding forest areas used remote sensing data classify forest areas based density applied matching methods propensity score matching different algorithms compare forest coffee areas without certification found certified forest coffee areas slightly increased forest density contrast observed drastic forest degradation forest coffee areas without certification checked sensitivity results found results robust potential hidden bias furthermore empirical results revealed natural forest areas within radius forest coffee boundary area exhibited significantly reduced forest degradation compared forest areas similar environmental conditions positive significant impact diminished distance results indicate certification program effective alleviating forest degradation certified area surrounding natural forest author published elsevier ltd
shape memory alloy sma type smart material huge driving force large driven displacement using sma structure driver may force directional deformation structure achieve high efficiency compact driving structure sma together elastic component forms two way driving structure however two respectively serving driver enable occurrence simplest directional drivable structure offset structure constituted sma achieve two way drive require continuous input energy shape stabilizing period paper studies design methods two structures gives typical formulas makes possible efficient compact directional drivable structures
shape memory materials type smart material potential applications sensors textiles aerospace engineering medical devices study prepared eucommia rubber high density polyethylene hdpe composites continuous architecture simple physical blending method shape memory composites memorized two temporary shapes using different melting points natural eucommia rubber hdpe addition dicumyl peroxide dcp architecture eucommia rubber hdpe composites critical materials properties component forms three dimensional percolating network good properties two components may synergically combined results showed memory behavior composites dependent degree crystallinity composites dcp phr physical mechanical properties eucommia rubber hdpe composites improved exhibited excellent shape memory behavior better values shape fixity ratio shape recovery ratio dcp phr crystalline phase eucommia rubber composites almost completely destroyed resulted one temporary shape memory behavior composites society chemical industry
sharing materials complex social behavior may lead longterm development friendships concomitant increases related prosocial behaviors given complexities sharing behaviors children social delays deficits may recognize share children social delays deficits especially disabilities may engage typical sharing behaviors behaviors important identifying interventions sharing related social behaviors crucial purpose review identify sharing interventions evaluate methodological rigor assess intervention effectiveness twenty single case designs published articles included studies reported variable results considerable methodological limitations results high quality studies promising provide foundation future research sharing behaviors
sharing tacit knowledge great importance integrated project team achieve success however research factors affecting tacit knowledge sharing within integrated project team insufficient construction management field paper aims identify critical factors affecting tacit knowledge sharing explore interrelationships factors based literature review authors first identify factors tacit knowledge sharing within integrated project teams questionnaire statistical test research next analyzes factors significant tacit knowledge sharing within integrated project team factors analysis used study critical factors tacit knowledge sharing finally authors analyze interrelations among critical factors explore influence tacit knowledge sharing within integrated project team findings research demonstrate impacts trust tacit knowledge sharing evolution trust taken account authors also find two personal factors related trust tacit knowledge sharing paper provide useful guidance integrated project team promote tacit knowledge sharing ultimately improve team performance american society civil engineers
shear banding observed many soft materials recently developed two fluid model semidilute entangled polymer solutions using generalized bracket approach nonequilibrium thermodynamics model assumes fickian diffusion stress induced migration generate nontrivial velocity difference polymers solution thereby resulting shear band formation straightforward implementation slip boundary conditions possible differential velocity treated state variable numerical calculations showed obvious shear banding polymer concentration profile increasing pressure gradient reduces inhomogeneity concentration profile moves transition region toward center channel moreover velocity deviates typical parabolic form shows plug like profile low shear band near center high one near walls lack hysteresis profiles volumetric flow rate calculated increasing decreasing pressure gradient demonstrates uniqueness solution addition flow rate exhibits spurt critical pressure gradient experimentally observed shear banding materials simplicity new model encourages analyze complicated flows elsevier rights reserved
shepperd macdonell evaluating prediction systems software project estimation information software technology proposed improved measure effectiveness predictors based comparing random guessing suggest estimating performance random guessing using monte carlo scheme unfortunately excludes correct guesses biases marpo slightly big turn causes standardised accuracy measure estimate slightly commonly used software engineering datasets practical calculate unbiased marn exactly elsevier rights reserved
shoot apical meristems produce stem tissues produce leaves produce flowers cell proliferation characteristics meristems dependent upon cell maturation processes functions newly formed cells cells stem terminals depend upon water availability plant portions inadequate moisture availability stem terminals reduces shoot growth rates leaf production rates xylem conductivity measurements terminal shoot meristems small leaves approximated using hagen poiseuille equation determine relationships xylem contributions leaves versus xylem conductivity within stems analyses petiole stem xylem conductivities herbaceous plant species confined stem terminals primary xylem cells stems five leaves leaf pairs among stem segments length among species largest leaf areas ranged stem diameters ranged maximum leaf petiole stem xylem conductivities mpa mpa respectively pooled samples petiole xylem conductivity well scaled leaf area largest leaves pooled samples stem conductivity well scaled cumulative petiole conductivities largest diameter stem sections species considered stem xylem conductivity well scaled mean radius conduits overall stem xylem conductivities strongly linked petiole conductivities leaves developed petiole xylem conductivity well scaled stem conductivities species markedly different leaf areas
shortcut methods valuable tools fast evaluation key performance indicators early phase conceptual process design design absorption columns operation minimum solvent demand represents thermodynamically sound indicator however difficult determine infinite number separation stages need considered instead suggested shortcut model exploits existence pinch point identify operation minimum solvent demand existing shortcut concepts well known equation kremser natl pet news significantly outperformed novel shortcut model gradually refined desired accuracy integration stepwise procedure results reliable solutions model covers rigorous thermodynamics simplifications regarding phase equilibrium heat effects number components required performance method illustrated several case studies seven components american institute chemical engineers aiche
shown first equivalence multiple expansion brain electrical generator spherical harmonic spectra shs potential generated electrical generator infinite volume conductor based equivalence shs spatial filters connect shs deduced concentric sphere conductor eeg source mappings cortical potential mapping cpm scalp laplacian mapping pseudo cortical potential mapping pcpm equivalent dipole layer mapping edm equivalent charge layer mapping ecm theoretical simulation study spatial filters mappings indicate mappings provide higher resolution imaging maps brain electrical activity scalp potential map inverse problem spherical spline fit algorithm provided reconstruct shs scalp recording potential shs maps mappings reconstructed utilizing spatial filters shs scalp potential results indicate correlativity order reconstructed map actual cortical potential map cpm greater equal edm pcpm ecm empirical vep data study shows one mappings also provides higher spatial resolution scalp potential map elsevier science ireland ltd rights reserved
siblings people disabilities exposure people disabilities nondisabled people uniquely positioning toward disability yet less known might impact attitudes study examined siblings disability attitudes determining siblings explicit implicit disability bias mapping dimensional prejudice examining theoretical variables might relevant attitudes disability attitudes implicit association test symbolic ableism scale survey questions administered siblings findings revealed majority siblings implicitly preferred nondisabled people despite reporting low levels explicit attitudes
sight word instruction useful supplement phonics based methods circumstances nonetheless studies evaluated conditions pictures may used successfully teach sight word reading study extended prior research examining two potential strategies reducing effects overshadowing using picture prompts five children developmental disabilities two typically developing children participated first experiment therapist embedded sight words within pictures gradually faded pictures needed using least prompting hierarchy second experiment therapist embedded text picture matching within sight word reading sessions results suggested strategies reduced interference typically observed picture prompts enhanced performance teaching sessions majority participants text picture matching also accelerated mastery sight words relative condition therapist presented text without pictures
signaling pathways driven protein lipid kinases altered human diseases therefore pharmacological inhibitors cell signaling one intensively pursued therapeutic approaches treatment diseases cancer neurodegeneration metabolic syndromes phosphoproteomics technique measures products kinase activities appropriate bioinformatics techniques methodology also provide measures kinase pathway activation network circuitry hence due recent technological advantages based quantitative phosphoproteomics provides relevant information design implementation kinase inhibitor based therapies review phosphoproteome profiling used translational research means identify drug targets biomarkers personalizing therapies based kinase inhibitors
significant progress made understanding pathophysiology rheumatoid arthritis widely recognized early institution treatment one best predictive factors response therapy several novel approaches currently investigated several novel biologics various stages development advances fields proteomics genomics metabolomics specific phenotypes disease better identified specific therapies particular phases disease specific patients allow improved control condition
silicon power amplifiers pas various front end modules fems today handset wlan applications even though iii semiconductor based pas still offer superior frequency breakdown performance higher pout power added efficiency pae faster time market silicon based pas advantages offering higher monolithic integration added functionalities chip digital control selection power level modulation frequency band matching predistortion etc translate lower cost smaller sizes attractive broadband multi mode multi band handset transmitters therefore key techniques designing high efficiency wlan broadband wireless silicon pas discussed
siloxanes usually used high temperature organic rankine cycle orc engine waste heat recovery flammability limits practical application besides blending siloxanes retardants often brings great temperature glide causing large condensation heat reduction net output power view zeotropic mixtures based siloxanes used dual loop organic rankine cycle dorc system proposed paper three kinds binary zeotropic mixtures consisting various siloxanes octamethylcyclotetrasiloxane octamethyltrisiloxane mdm decamethyltetrasiloxane mdm represented mdm mdm selected working fluid high temperature cycle meanwhile always used low temperature cycle net output power utilization heat source considered evaluation indexes select optimal mixture ratios analysis based thermodynamic economic model net output power thermal efficiency exergy efficiency exergy destruction electricity production cost epc dorc system using selected mixtures investigated different operating parameters according results dorc based shows best thermodynamic performance largest net power highest thermal efficiency also largest exergy efficiency smallest total exergy destruction dorc using mdm represents economic system smallest epc besides irreversibility internal heat exchanger turbine evaporator cycle contributes total exergy destruction serve parameter optimized study elsevier ltd rights reserved
silver known centuries powerful disinfectant known harmful effects humans applied adequate doses although use partially discontinued advent chlorination modern antibiotics discovery bacterial resistance disinfection products enabled emergence viable water purification option hand implementation small scale rainwater harvesting rwh systems received little attention possibly due general perception complex expensive technology overcome efficient designs dose silver ions water minimal cost authors evaluated dozen rwh systems equipped silver releasing devices providing drinking water schools clinics rural area mexico paper represents follow previously published study evaluation performed region number water quality parameters analysed examining long term efficiency projects observations show silver ion devices act effective disinfection mechanism long adequate maintenance provided combination conventional settling tanks filtration units seems greatly enhance overall performance system
similarly inorganic memristors organic memristive devices reveal variation hysteresis loop upon frequency applied bias voltage ratio conductivity increases limes variation time delay equilibration application voltage increment implemented multi element electrical circuits memristive devices provide cross talk leading equilibration trend conductivity values effect mainly related formation stable signal pathways elsevier ltd rights reserved
simtuzumab monoclonal antibody inhibitor extracellular matrix enzyme lysyl oxidase like showed preclinical promise well tolerated clinical studies phase open label study simtuzumab conducted patients primary myelofibrosis post polycythaemia vera post essential thrombocythaemia fifty four patients randomized receive simtuzumab alone group simtuzumab ruxolitinib group weeks simtuzumab alone combination ruxolitinib showed clinical benefit weeks mean serum simtuzumab trough concentrations appeared increase dose proportionally treatment groups therapy related serious adverse events pyrexia pain extremity patient infusion reaction another patient bone marrow fibrosis bmf score reduced weeks patients simtuzumab group simtuzumab ruxolitinib group simtuzumab ruxolitinib group similar numbers patients increased bmf simtuzumab alone ruxolitinib well tolerated produce clinical benefit consistently reduce bmf patients weeks
since april artemis ecsel project emc running provides significant results emc stands embedded multi core systems mixed criticality applications dynamic changeable real time environments paper report recent progress technical work different workpackages use cases highlight progress research system architecture design methodology platform operating systems qualification certification application cases fields automotive avionics health care industry presented exploiting technical results achieved
since data resources massive feature feature data increasingly complex traditional data structures suitable current data anymore therefore traditional single label learning method meet requirements technology development importance multi label leaning method becomes highlighted nearest neighbor knn classification method lazy learning method data classification methods need data training process theoretical system mature addition principle implementation simple paper proposed improvements strategies considers numerical feature sample knn classifying consider disadvantage sample structure feature paper introduced particle swarm optimization algorithm knn classification make adjustments euclidean distance formula traditional knn classification algorithm add weight value feature using adjusted distance formula train training data particle swarm optimization algorithm optimized set weight value features put optimized weight values adjusted distance formula calculated distance example test data set training data set predict test data set experiment results show weighted knn classification algorithm based particle swarm optimization algorithm achieve better classification accuracy traditional knn classification algorithm
since social psychologists conducted research testing whether possible accurately identify members perceptually ambiguous groups study quantitatively reviews research perception ambiguous groups better understand human capacity accurately identify others based subtle nonverbal cues standard random effects meta analytic techniques used examine distinctions different target groups terms identifiability well compare rates accuracy across perceptual modalities photographs audio video study design differences overall accuracy identifying targets significantly better chance guessing furthermore stimulus modality found moderator accuracy moderators time exposure analytic approach identified examined data help document characterize broad trends proliferating expanding study perception categorization ambiguous social groups
since widely accepted nicotine addictive drug discussions smoking inevitably lead smokers reflect addiction smokers perceptions nicotine addiction specifically rarely studied smokers understandings nicotine addiction increasingly relevant light emergence electronic cigarettes cessation aids containing nicotine potential use long term replacements cigarettes article based thematic discourse analysis interviews smokers large metropolitan city australia explore smokers negotiate concept nicotine addiction relation smokers influences views smoking cessation methods starting image nicotine addict show participants accept distance image framing source addiction habit addicted rather nicotine addicted also discuss function habit talk way contextualising addiction report notions addiction shape participants views cessation methods finally discuss implications findings future research health professionals working smokers
since decision non price feature product quality draws little attention literature dual channel supply chains paper investigates price quality decisions dual channel supply chains single product delivered retail channel direct channel dual channel retail direct channels considering supply chains centralized decentralized demonstrate quality improvement realized new channel introduced moreover employ two themes terms channel adding pareto zone characterize impacts channel structures supply chain performance including whole system profit centralized system player profit decentralized system consumer surplus price quality decisions considered find supply chain performance could improved due new channel augmented moreover show effects quality sensitivity parameters different channels price product quality well profits consumer surplus elsevier rights reserved
since effects external conditions limited resource supplies poor working environments damaged regions critical facility restoration projects catastrophic disaster lack understanding regarding restoration conditions may lead unexpected delays additional project costs fact various elements postdisaster restoration conditions interact vary facility surrounding damage recovery situations time makes many stakeholders comprehension even challenging support immediate appropriate facility restoration planning changing project conditions study developed hybrid system dynamics discrete event simulation des framework hybrid restoration simulation allows comprehensive understanding dynamic features various restoration conditions des enables depth examination facility restoration operations according external condition changes allowing two simulations seamlessly interact together study provides key insights postdisaster restoration including complex critical restoration conditions change time depending facility types subregions extent conditions adversely impact project performance uncertainty throughout lengthy project durations especially restoration work scope processes vary damage patterns test tool analyzing effectiveness managerial policies also provided showing experimental results instance project initiation postponed avoid unfavorable restoration conditions delayed reduce project uncertainty alleviating possible increases wasted time cost running unproductive site therefore major contribution research body knowledge construction engineering resides capacity developed hybrid model make facility restoration planning execution deal project uncertainties caused chaotic disrupting external conditions unexpected delays additional costs common postdisaster recovery alleviated
since publication premack woodruff classic paper introducing notion theory mind premack woodruff behav brain sci interdisciplinary research social cognition witnessed development theory theory simulation theory hybrid approaches recently interactionist perceptual accounts minds challenges various approaches present research social cognition range adequately defining central concepts designing experimental paradigms testing empirical hypotheses approach promises dominate future interdisciplinary research social cognition social cognition witnessing gradual paradigm shift hitherto grounding notions theory mind longer viewed explanatorily necessary simply lost way attempting devise adequate experimental setups could sway debate favour one contending accounts special issue addresses questions attempt discover future holds interdisciplinary research social cognition
since discovery mammalian brain apparent serotonin dopamine interactions play key role normal abnormal behavior therefore disclosure interaction could reveal important insights pathogenesis various neuropsychiatric diseases including schizophrenia depression drug addiction neurological conditions parkinson disease tourette syndrome unfortunately interaction remains difficult study many reasons including rich widespread innervations brain plethora receptors release transmitters neurons purpose review present electrophysiological biochemical data showing endogenous pharmacological ligands modify mesencephalic systems activity receptors may control neuron activity state dependent region dependent manner controls activity neurons phasic excitatory manner except control exerted htc receptors appears also tonically constitutively inhibitory functional interaction two monoamines also discussed view mechanism action antidepressants antipsychotics anti parkinsonians drugs abuse elsevier ltd rights reserved
since xml could benefit greatly database support specifically relational database systems study methodology modeling fuzzy spatiotemporal data xml transforming fuzzy spatiotemporal data xml relational databases well accomplish devise fuzzy spatiotemporal data model xml capture semantics fuzzy spatiotemporal features allow better platform independent sharing fuzzy spatiotemporal data stored relational format propose temporal edge approach transform fuzzy spatiotemporal xml data relational databases unique feature approach schema information required transformation fuzzy spatiotemporal data moreover temporal spatial fuzzy features fuzzy spatiotemporal data xml documents taken consideration finally experimental results demonstrate performance advantages approach approach transformation could provide significant consolidation interoperability fuzzy spatiotemporal data xml relational databases
single multi component adsorptive removal aqueous solutions onto sepiolite studied present study removal radionuclides single systems found strongly dependent initial solution removals achieved initial values higher respectively kinetic data equilibrium isotherms modeled two kinetic models pseudo first order pseudo second order two isotherm models langmuir freundlich respectively effect various coexisting cations different concentrations adsorption processes concerned radionuclides single systems evaluated desorption studies radionuclide loaded sepiolite studied using different concentrations organic edta strong complexing agents radionuclides inorganic hci naci cacl alcl desorbing agents adsorption mechanisms radionuclides onto sepiolite deeply discussed multi component adsorptive removal onto sepiolite function adsorbent weight time also studied influence solution removal efficiency radionuclides investigated presence edta furthermore present investigation evaluated removal efficiency radionuclides multi systems presence different concentrations either naci cacl elsevier rights reserved
single inductor multiple output simo switching power converter architecture cost effective alternative multiple individual switching power converters solution many power distribution system applications multiple voltage rails required reduced cost however multiple output voltage rails coupled switching node simo power converters suffer cross regulation multiple outputs complicates closed loop controller design simo converter degrades regulation performance paper power multiplexed control scheme proposed aiming completely decouple operations multiple outputs one another proposed control scheme results eliminating cross regulation among multiple outputs maintaining desired voltage regulation performance output steady state dynamic operations low cost microcontroller analog circuitries used implement proposed controller experimental proof concept prototype results verify feasibility advantages proposed controller
situation awareness computing paradigm allows applications sense parameters environment comprehend meaning project status next future collaborative situation awareness challenging area field ambient intelligence applications situation patterns emerge users collective behavior paper introduce multi agent system exploits positioning information coming mobile devices detect occurrence user situations related social events functional view system first level information processing managed marking agents leave marks environment correspondence users positions accumulation marks enables stigmergic cooperation mechanism generating short term memory structures local environment information provided structures granulated event agents associate certainty degree event finally inference level managed situation agents deduces user situations underlying events exploiting fuzzy rules whose parameters generated automatically neuro fuzzy approach fuzziness allows system cope uncertainty events architectural view system adopt semantic web standards guarantee structural interoperability open application environment system tested different real world scenarios show effectiveness proposed approach elsevier rights reserved
size complexity power systems impose significant challenges power system analysis control power system becomes complex great need develop improved sophisticated tools power system analysis simulation tools able accurately replicate real events occur electric power network help understand dynamics changes number software packages developed power system research analysis planning designing teaching paper describes utilize electric power system analyzer psa useful instrument power flow studies analyzer designed user friendly easy use ability optimize power flow visualize effects changing problem parameters psa handle power system networks nodes
sizing storage rainwater harvesting rwh systems often difficult design consideration system must designed specifically local rainfall pattern introduce generally applicable method estimating required storage using regional regression equations account climatic differences behavior rwh systems across entire continental united states series simulations locations continuous daily precipitation records enable development storage reliability yield sry relations four useful reliabilities multivariate log linear regression results storage equations include demand collection area local precipitation statistics continental regression equations demonstrated excellent goodness fit using two precipitation parameters fits improved three geographic regions homogeneous rainfall characteristics considered sry models used obtain preliminary estimate large build storage tank almost anywhere united states based desired yield reliability collection area local rainfall statistics methodology could extended regions world equations presented herein could used investigate rwh systems would respond changes climatic variability resulting model may also prove useful regional planning studies evaluate net benefits result broad use rwh meet water supply requirements outline numerous possible extensions work taken together illustrate value initial generalized sry model rwh systems
skeletal dysplasias represent large diverse group rare conditions affecting collagen bone clinically classified based radiographic physical features many defined molecular level bonafe early diagnosis critical proper medical management including pharmacologic treatment available patients severe skeletal dysplasias often small chests respiratory insufficiency airway obstruction require immediate intubation birth thereafter variety orthopedic neurosurgical pulmonary otolaryngology interventions may needed terms definitive treatment skeletal dysplasias pharmacotherapeutic options available majority conditions sought describe therapies currently available investigation skeletal dysplasias
skin biophysical properties indicate skin condition also systemic status human organism understanding skin physiological chemical biophysical characteristics helps arrange proper approach management skin diseases also skin analysis allows people take control skin care detecting possible issues early reduce amount treatments might needed costs involved study non invasive skin biophysical parameter used comparision hydration tran epidermal water loss tewl normal psoriasis vitiligo affected skin using dermalab series skin lab combo equipment anatomical locations selected measurements forehead volar forearm mid region dorsal hand neck individual study found baseline tewl hydration depends anatomical regions variation parameters found great extent psoriasis compared normal vitiligo affected skin
skin prick testing spt combination clinical history patient one important step diagnosis ige mediated occupational allergies however skin test performance related quality allergen extracts present consensus document prepared eaaci task force consisting expert panel allergologists occupational physicians germany italy spain france austria poland members panel also involved data collection within european multicentre study stadoca standard diagnosis occupational allergy aim task force assessment quality commercially available spt solutions selected occupational allergens standardized procedure conditions different european centers institutes occupational medicine data evaluation shows wide variability among spt solutions also indicated sensitivity several spt solutions low therefore improvement standardization spt solutions occupational allergens highly recommended clinical practitioners also presume spt solutions fully reliable main objective document issue consensus suggestions use spt occupational allergens based european multicenter study stadoca existing scientific evidence expertise panel allergologists
sleep disorders insomnia nightmares commonly associated borderline personality disorder bpd adulthood whether nightmares sleep onset maintenance problems predate bpd symptoms earlier development unknown addressed gap literature using data avon longitudinal study parents children alspac participants included adolescents female completed childhood interview dsm bpd years age nightmares sleep onset maintenance problems prospectively assessed via mother report children years age psychopathological emotional temperament psychiatric diagnoses emotional behavioural problems psychosocial abuse maladaptive parenting family adversity confounders assessed via mother report logistic regressions persistent nightmares regular nightmares time points significantly associated bpd symptoms following adjustment sleep onset maintenance problems confounders adjusted odds ratio confidence interval persistent sleep onset maintenance problems significantly associated bpd symptoms path analysis controlling associations confounders persistent nightmares independently predicted bpd symptoms probit efficient beta emotional behavioural problems significantly mediated association nightmares bpd beta nightmares significantly mediated associations emotional temperament beta abuse beta maladaptive parenting beta subsequent bpd findings tentatively support childhood nightmares may potentially increase risk bpd symptoms early adolescence via number aetiological pathways replicated current findings could important implications early intervention assist clinicians identification children risk developing bpd
sleep known important component recovery training yet little known quality quantity sleep achieved elite athletes aim present study quantify sleep elite athletes using wristwatch actigraphy individual nights sleep cohort olympic athletes various sports analysed compared non athletic controls significant differences athletes controls measures apart time asleep suggesting poorer characteristics sleep athlete group significant effect gender time awake mean difference minutes higher males likely range minutes sleep efficiency mean difference lower males likely range athletes showed poorer markers sleep quality age sex matched non athletic control group sleep efficiency respectively fragmentation index respectively remained within range healthy sleep descriptive study provides novel data purpose characterising sleep elite athletes
slow light systems particularly attractive analog signal processing since inherent limitation delay bandwidth product less critical analog systems used microwave photonics present implementation two basic functions phase shifting true time delaying fully optically controlled using stimulated brillouin scattering optical fibers combination two functions makes possible implementation true time delays without limitation microwave carrier frequency using separate carrier tuning technique illustrated implementation delaying system realization microwave tunable notch filter
slow response self powered neutron detectors spnds vanadium rhodium emitters found wide application nuclear power plants core flux mapping well power regulation used input power regulation system protection system detector signals must undergo time compensation counteract inherent delay associated beta decay number compensation techniques developed vanadium rhodium slow response spnds including analog digital approaches however noticed majority compensation techniques based laplace transformations inevitably requires kind approximation map domain domain words prevailing approaches neither straightforward accurate due complex manipulations representations different domains moreover reported methods generally developed case case fashion without addressing issue generalized approach applies kinds slow response spnds overcome limitations deficiency propose paper unified framework model slow response spnds discrete time state space representation proposed method eliminates complicated manipulations domain achieves accurate compensation without approximation means state space representation spnd dynamics advanced digital signal processing techniques continuous discrete domain derived discrete time state space spnd model also readily facilitates application state art signal processing algorithms kalman filtering proved highly accurate effective similar applications
sludge taken wastewater treatment plant petrochemical industry dewatered pyrolyzed produce liquid oil alternative fuel via microwave heating element contents dried sludge carbon hydrogen nitrogen sulfur two major thermal degradation peaks sludge determined microwave pyrolysis process one water vaporized weight loss sludge constituent decomposition content high dried raw material residues toxic elements contents respectively oil produced based dried sludge cake oil major elements heat values liquid oils kcal degrees elsevier rights reserved
small scale thermal treatment municipal solid waste msw investigated using mass energy balances based assumption thermodynamic equilibrium typical average msw composition literature used basis modelling one ton per day waste gasification facility plant syngas production pyrolysis stoichiometric addition auto thermal gasification oxygen air external heat input required combustion considered cases evaluated production electricity steam purely thermodynamic considerations observed auto thermal oxygen gasification produces electricity kwe oxygen plasma gasification produces positive net amount kwe ton per day scale although auto thermal air gasification also produces net positive amount calorific value syngas low fuel internal combustion engine expected amount steam generated different scenarios high due higher process efficiencies close coupled auto thermal oxygen process proved efficient cost additional oxygen generation however taken account may change picture significantly
smart environments learning considered new level computer enhanced learning number new interesting facilities famous ist advisory group istag report started decade various research initiatives rapidly growing area ambient intelligence introduced also smart environment example form scenario scenario annette solomon ambient social learning vision learning environment based position learning social process scenario certainly nice incentive number new initiatives focused less successful attempts design introduce various types smart environments capable support different aspects learning process multi agent systems frequently used approach towards smart environments design general convinced really systematic approach towards reflecting desirable functionalities smart learning environments must based well designed multi agent architecture paper intend firstly map recent state art area smart environments designed learning wish list desirable functionalities smart environment learning propose multi agent architecture capable reflecting functionalities smart environment similar described mentioned scenario
smart grid electrical network uses digital advanced technology monitor manage transport electricity generating sources meet varying demand end users important nodes smart grid phasor measurement unit pmu smart meter phasor data concentrator pdc pmu within substation form communication network gate way node called phasor data concentrator updates data pmu within cluster range proper management data exchange pmu pdc essential thing meet concept smart grid paper considering pmu sensor node pdc central node data exchanged nodes proposed intrusion detection algorithm packet loss avoidance using time division multiple access tdma protocol security algorithm improves system security response malicious attacks network simulator used create simulation scenario detecting attacks hardware tested using lpc microcontrollers zigbee authors published elsevier ltd
smart grids considered one revolutionary technologies field power communication however security management big infrastructure key challenge research community world context paper provides major security goals smart grid systems along classification different vulnerabilities additionally also present remedial measures prevent security threats end provide conclusions future works finalize analysis security issues smart grid
smart homes pervasive environments enhance comfort security safety energy consumption residence ambient intelligence system uses information devices represent context home residents based context database system infer daily life activities resident hence abnormal behavior chronic disease detected system due complexity systems large variety anomalies may occur disrupt functioning critical essential applications detect anomalies take appropriate measures anomaly management system integrated overall architecture paper propose anomaly management framework smart homes framework eases work designers conception anomaly detection modules processes respond anomaly appropriately framework used heterogeneous environments smart home uses semantic web ontologies represent anomaly information framework useful detect hardware software network operator context faults test efficiency anomaly management framework integrate universaal middleware based reasoner framework easily infer context anomalies take appropriate measures restore system full functioning state authors published elsevier
smart manufacturing dramatically intensified pervasive application networked information based technologies throughout manufacturing supply chain enterprise defining technical threads time synchronization integrated performance metrics cyber physical workforce requirements smart manufacturing responds leads dramatic fundamental business transformation demand dynamic economics keyed customers partners public enterprise performance variability management real time integrated computational materials engineering rapid qualification demand driven supply chain services broad based workforce involvement enabled smart factories supply networks better respond national interests strategic imperatives revitalize industrial sector facilitating global competitiveness exports providing sustainable jobs radically improving performance facilitating manufacturing innovation elsevier ltd rights reserved
smart thermal grids stgs able perform function classical grids developed order make better use distributed possibly intermittent thermal energy resources provide required energy needed efficient resources utilization intelligent management district heating plays significant role implementation future smart energy systems fulfil role technologies must developed integrate renewable resources create low temperature networks consequently make existing new networks ready integration future stgs solar heating promising option low temperature systems thermal energy storage tes make availability energy supply match demand integration centralized seasonal distributed short term thermal storages would facilitate efficient recovery solar energy study modelling simulation investigates impacts integration overall performance community level solar system performance analysis results show solar system integration distributed centralized seasonal tess improves system overall efficiency reduces network heat losses primary energy consumption greenhouse gas emissions comparison one without integration crown copyright published elsevier ltd rights reserved
social affiliation essential many species gains significant importance adolescence disturbances social affiliation particular social rejection experiences adolescence affect individual well involved emergence psychiatric disorders underlying mechanisms still unknown partly lack valid animal models using novel animal model social peer rejection compromises adolescent rats ability appropriately engage playful activities report persistent impairments social behavior dysregulations endocannabinoid ecb system postnatal day adolescent female wistar rats either reared strain partners control within group fischer rats inadequate social rearing isr previously shown serve inadequate play partners wistar strain adult isr animals showed pronounced deficits social interaction social memory processing socially transmitted information decreased pain sensitivity molecular analysis revealed increased receptor protein levels stimulated gtp gamma binding activity specifically amygdala thalamus previously peer rejected rats along changes increased levels ecb anandamide aea corresponding decrease degrading enzyme fatty acid amide hydrolase faah seen amygdala data indicate lasting consequences social behavior pain sensitivity following peer rejection adolescent female rats behavioral impairments accompanied persistent alterations cbi signaling finally provide novel translational approach characterize neurobiological processes underlying social peer rejection adolescence
social class predicts numerous important life outcomes social orientations date literature mainly examined individual class shapes interactions others prosocially people treat others perceive coming lower middle higher social classes addition testing effects self social class prosocial behavior also investigate target social class affects prosocialbehavior operationalized using social mindfulness paradigm focuses leaving limiting choice others offer three lines reasoning predicting lower class targets either elicit greater prosociality higher class targets fairness higher class targets elicit greater prosociality status people prosocial targets social class similarity across four studies find participants behave less prosocially less socially mindful toward higher class targets relative lower middle class targets perceptions similarity warmth competence mediate lower prosociality higher relative lower class targets together results consistent fairness perspective across studies also found self social class little relationship prosociality total results suggest social class relevant prosocial behavior target social class matters self social class elsevier inc rights reserved
social communicative deficits stereotyped repetitive interests behaviors defining features autism spectrum disorder asd growing body research suggests gross motor deficits also present children asd study sought understand pediatric asd severity related motor skills social skills multivariate analysis variance analysis children autism asd revealed nonsignificant difference groups results suggest little difference severity groups gross motor social skills within limited age range participants years age
social initiations make core deficit children autism spectrum disorder asd particular initiated questions social interactions often minimal absent population context multiple baseline design efficacy using motivational procedures pivotal response treatment increase social question asking three young children autism assessed results indicated participants initiated greater number targeted questions following intervention additionally children exhibited increases initiation untargeted questions social interaction novel settings furthermore post intervention data revealed collateral gains communication adaptive behavior theoretical implications incorporating motivational strategies intervention improve social initiations young children asd discussed
socioeconomic status ses significant risk factor negative adolescent development outcomes identifying pathways ses outcomes may inform interventions adolescents demographic conducted systematic literature review eight databases studies investigating pathways ses adolescent psychosocial outcomes total articles met inclusion criteria significant risk factors identified include economic stress chaos home violence community risk factors appear mediated parent depression conflict parents parenting practices adolescent resilience interventions focusing identified risk factors recommended
sociological social psychological economic research nexus socioeconomic status prosociality far provided contradictory findings studies suggest actors high socioeconomic status act egoistically actors lower socioeconomic status studies find opposite true contrast previous research worked one dimensional measures socioeconomic status study examines prosocial behavior among occupational groups regular real life contact workspace hospital employees physicians nursing staff nursing students participated experiments altruistic giving dictator games findings surprisingly strong clear cut actors higher social status act prosocial low status actors furthermore find hardly group effects repeatedly postulated findings support claim high status promotes prosocial behavior also indicate inconclusive part contradictory findings provided previous research stem considerable degree deficient measures social status problematic experimental designs
soft computing opposed traditional computing deals approximate models gives solutions complex real life problems unlike hard computing soft computing tolerant imprecision uncertainty partial truth approximations effect role model soft computing human mind soft computing based techniques fuzzy logic genetic algorithms artificial neural networks machine learning expert systems although soft computing theory techniques first introduced become major research study area automatic control engineering techniques soft computing nowadays used successfully many domestic commercial industrial applications advent low cost high performance digital processors reduction cost memory chips clear techniques application areas soft computing continue expand paper gives overview current state soft computing techniques describes advantages disadvantages soft computing compared traditional hard computing techniques authors published elsevier
soft tissue reactions paraffin include inflammation fibrosis disfigurement granulomatous inflammation foreign body giant cell reaction authors report case year old woman cutaneous marginal zone cell lymphoma located glabella arising association underlying paraffinoma unclear whether implant directly contributed development lymphoma association previously documented prompting report
software defined networking sdn recently emerged become one promising solutions future internet logical centralization controllers global network overview sdn brings chance strengthen network security however sdn also brings dangerous increase potential threats paper apply deep learning approach flow based anomaly detection sdn environment build deep neural network dnn model intrusion detection system train model nsl kdd dataset work use six basic features easily obtained sdn environment taken fortyone features nsl kdd dataset experiments confirm deep learning approach shows strong potential used flow based anomaly detection sdn environments
software systems tend become larger complicated functional requirements increase gradually well modularized software systems widely believed understood managed evolved easily software module clustering problems smcps significant challenging problems software engineering whose primary aim obtain perfect structures software systems according predefined rules solve smcps important design measure appropriately evaluate quality structures obtained far modularization quality basic widely used conventional measure however measure consider global modules edge directions two modules therefore paper design new modularization quality measure based similarity labeled automatically guide optimization algorithms find good partition software systems considers global modules edge directions systematically validate performance three optimization algorithms namely hill climbing algorithm genetic algorithm multi agent evolutionary algorithm maea adopted optimize real world software systems varying sizes thorough comparison shows outperforms basic guiding optimization algorithms find meaningful module clusters software systems elsevier inc rights reserved
soil varies location location result complex combinations soil forming factors processes operating different scales intensities scale dependent variability soil properties causes challenges characterization mapping soils advent technologies proximal sensors gamma radiometrics characterize soil spatial variability digital mapping soil properties study aim characterize scale dependent variability proximal gamma radiometrics complex relationship soil properties different scales using wavelet transform wavelet coherency measured gamma radio metrics gamma ray potassium uranium thorium total count gamma using hand held device field every along transect point measured elevation land use collected soil samples determine key soil properties electrical conductivity cacl soil organic carbon soc cation exchange capacity cec exchangeable potassium exch colwell wavelet spectra identified significant variations different scales locations gamma ray soil properties significant localized variations changes elevation land use also important cases global pearson correlation gamma ray soil properties significant contrast wavelet coherency provided powerful scale location specific relationship gamma ray elevation land use selected soil properties example strong correlation area significant detected land use soil scales significant positive correlations gamma soc area medium scales similar significant positive correlations cec area along first half transect underlain bushy creek granodiorite findings provide improved understanding spatial variability gamma ray soil relationships approach used shows scope significant potential use wavelet analysis gamma soil property relationships scale specific would useful digital soil mapping moreover scale specific spatial information soil properties aids understanding soil formation processes illustrates approach improve future soil sampling strategies elsevier rights reserved
soil reinforcement interaction mechanism important issue design geosynthetic reinforced soil structures mechanism depends soil properties reinforcement characteristics interaction two elements soil reinforcement work shear strength sand geotextile interfaces characterized direct simple shear tests direct shear tests performed conventional direct shear device large scale direct shear apparatus unreinforced sand one layer reinforced sand specimens characterized trough simple shear tests interfaces shear strength achieved large scale direct shear device slightly larger obtained conventional direct shear apparatus notwithstanding differences shear strength characterization simple shear direct shear tests concluded shear strength one layer reinforced sand similar sand geotextile interface direct shear strength
solar energy alternative source fossil fuel photovoltaic thermal solar systems emerged important research area result rising global concern utilization energy resources oil gas solar systems utilize photovoltaic system generate electricity thermal collector system hot water generation study experimental investigation concentrated system conducted december study evaluates performance pure thermal integrated solar system concentrated linear fresnel lens sun characteristic module indicates electrical efficiency cells normal condition decreases result solar concentration however output power module increased total efficiency pure thermal systems linear solar concentration reach respectively values indicate good thermal electrical performance metrological weather conditions shanghai china elsevier ltd rights reserved
solar photocatalytic degradation indoor formaldehyde advanced technology due durability stability friendly cost zero energy input article proposes combined system photocatalytic oxidation trombe wall pco simultaneously realize space heating removal indoor contaminants ceramic fiber paper tio film prepared method dipping depending complicated working conditions pco system effects multiple factors including formaldehyde concentration humidity temperature light intensity pco rate considered conversion experiments multiple factors conducted investigate performance kinetics ceramic fiber paper tio film photocatalytic degradation indoor formaldehyde experimental factors included typical indoor formaldehyde concentration ppb humidity typical solar light intensity temperatures degrees kinetic model simultaneously considering four explored factors proposed results showed proposed kinetic model fit experimental data well degree fitting rmsd based four variable kinetic model factors optimizing target increasing photocatalytic reaction rate cold warm seasons analyzed relative effective optimized measures proposed elsevier ltd rights reserved
solar driven photocatalytic water splitting promising technology produce energy herein demonstrate fabrication ternary catalyst tio cds chemical bath deposition ion exchange efficient photocatalytic water splitting based hydrogenated tio tio roughened surface hollow structures prepared tio cds ternary structure make use full solar spectrum better response near infrared region tuned bandgap alignments ternary heterostructure enable efficient separation photogenerated electrons holes leading hydrogen production rate high molg without noble metal catalyst meanwhile photocatalytic hydrogen production rate molg maintained five cycles believe fabricated noble metal free ternary heterostructure catalyst great potential solar energy conversion improved solar energy absorption efficient electron hole separation
solitude verification arguably one simplest fundamental problems distributed computing goal verify unique contender network paper devises quantum algorithm exactly solves problem anonymous network known network model minimal assumptions angluin stoc algorithm runs rounds every party initially common knowledge upper bound number parties implies solvable problems solved rounds average without error zero sided error network generalization quantum algorithm works log max rounds obtained problem exactly computing symmetric boolean function distributed input bits constant bits whose sum larger element algorithms work bit complexities bounded polynomial
solubility bosentan ethanol water mixtures experimentally determined five different temperatures respect composition solvent mixture results indicate ethanol temperature dependent increase bosentan solubility thermodynamic properties solution process calculated using van hoff gibbs equations generated solubility data correlated number cosolvency models accuracies predicted solubilities model performance illustrated mean percentage deviation mpd obtained mpd values cosolvency models trained using whole data points varied elsevier rights reserved
soluble alpha synuclein alpha syn oligomer believed reliable molecular biomarker diagnosis parkinson disease thus critical develop simple method selective detection alpha syn oligomer low cost well high sensitivity paper reported label free detection alpha syn oligomer using dna aptamer bioreceptor techniques gold nanoparticles aunps based colorimetric assay surface plasmon resonance spr electrochemical impedance spectroscopy eis colorimetric assay aptamer adsorbed onto surface aunps prevent salt induced aggregation nanoparticles however specific binding alpha syn oligomer aptamer prevented absorption aptamer onto surface aunps result aggregation aunps triggered high concentration salt color change red blue spr eis based surface analysis specific binding alpha syn oligomer aptamer immobilized onto gold film electrode surface led increase spr dip shift electron transfer resistance detection limits colorimetry spr eis found respectively amenability method alpha syn oligomer analysis biological matrix demonstrated assay alpha syn oligomer serum elsevier rights reserved
solution proposed make use rainwater thermal energy highly urbanised areas demonstrated stormwater heat represents additional site renewable energy available hot water production proposed solution increases multi functionality urban infrastructure essentially used mitigate impacts extreme climate events integrated system model applications correspond local area conditions north eastern baltic region study considers optimal collection stormwater maximizing water absorbed heat usage relation hot water consumption different building types residential public commercial two key parameters stormwater volume storage tank rainwater catchment area determined genetic algorithm finds number storage tank fillings corresponding rainfall statistics hot water consumption buildings system cumulative expenses related stormwater storage rainwater harvesting expenses
solutions presented laminar developing flow curved pipe parabolic inlet velocity laminar transitional flow downstream curved pipe straight outlet scalings linearized analyses appropriate base states used show cases obey governing equations boundary conditions particular governing equations two cases linearized fully developed poiseuille flow cylindrical coordinates dean velocity profile curved pipe flow toroidal coordinates respectively subsequently identify appropriate scalings axial coordinate disturbance velocities eliminate dependence reynolds number dimensionless pipe curvature alpha governing equations boundary conditions limit small alpha large direct numerical simulations confirm scaling arguments theoretical solutions range alpha maximum values axial velocity secondary velocity pressure perturbations determined along curved pipe section results collapse scalings applied theoretical solutions shown valid dean numbers alpha developing flows shown numerically analytically contain spatial oscillations numerically determined decay velocity perturbations also used determine entrance development lengths flows shown scale linearly reynolds number prefactor similar larger textbook case developing flow straight pipe
authors called attention lack service integration related evaluation treatment parental substance abuse ongoing challenge service providers cross training project involving exchanges immersion sessions among clinical teams established improve integration effectiveness coherence interventions pregnant women mothers problematic substance use prevent negative impacts substance abuse parenting skills foetal child development research goal understand perspectives care providers cross training either fosters fails foster changes practices care providers work young pregnant women mothers whose use psychotropic drugs puts risk neglecting children cross training project carried last phase project focus group data collected different clinical teams fields substance abuse child protection perinatality early childhood responses focus group yielded data thematic analysis performed using mixed coding approach included predefined emerging themes points convergence divergence identified comparing said different groups types clinical settings conclusion project care providers said knew clinical partners better communicated made referrals partners better able express clearly effects psychotropic drug use foetus child parenting role conclusion project helped create culture operation partnership direct effects services pregnant women young mothers use substances
children high functioning autistic spectrum conditions asc noted clinically produce accounts responses akin confabulations neurological patients neurological confabulation typically associated abnormalities frontal lobes related structures forms linked poor performance source monitoring executive function tasks asc also linked atypical development frontal lobes impaired performance source monitoring executive tasks confabulation autism knowledge previously examined experimentally investigated whether patterns confabulation autism might share similarities neurologically based confabulation tests confabulation elicitation source monitoring reality monitoring plus temporal task context memory executive function administered four adolescents asc previously noted confabulate spontaneously everyday life scores compared typically developing asc control group one confabulating participant significantly impaired reality monitoring one significantly worse task context test relative asc controls three confabulators showed impairment measures executive function brixton test cognitive estimates test hayling test errors relative control groups three significantly poorer controls two others hayling times asc control group also significantly slower test controls compared controls two four confabulating participants produced abnormal number confabulations confabulation elicitation questionnaire asc controls controls differ results raise possibility least cases confabulation autism may less related social factors impaired source memory poor executive function elsevier ltd rights reserved
domestic animals thought skilled social communication humans due process domestication horses close relationship humans similar dogs might skilled communication humans previous studies indicated sensitive bodily signals attentional state humans however studies investigate communication humans responses knowledge state humans first question whether horses send signals potentially helpful ignorant caretakers problem solving situation food item hidden bucket accessible caretakers examined whether horses alter behaviours basis caretakers knowledge food hidden found horses communicated caretakers using visual tactile signals signalling behaviour horses significantly increased conditions caretakers seen hiding food results suggest horses alter communicative behaviour towards humans accordance humans knowledge state
activities laboratory manufacturing technology ntua manufacturing engineering reported focusing onto recent trends developments advanced manufacturing advanced materials important engineering topics nowadays industrial research academic point view nanotechnology nanostructured materials synthesis net shape fabrication superconductors biomedical engineering solar energy devices
previous research stress memory interactions suggested stress increases production false memories however accumulating work shown effects stress learning memory depend critically timing stressor hypothesized brief stress administered immediately learning would reduce rather increase false memory production present study participants submerged dominant hand bath ice cold water stress sat quietly stress min participants completed short term memory task deese roediger mcdermott paradigm presented different lists semantically related words candy sour sugar list tested memory presented words candy non presented unrelated distractor words hat non presented semantically related critical lure words sweet stress overall significantly reduced number critical lures recalled false memory participants addition stress enhanced memory presented words true memory female male participants findings reveal stress unequivocally enhance false memory production timing stressor important variable could mediate effects results could important implications understanding dependability eyewitness accounts events observed following stress elsevier inc rights reserved
patients hip osteoarthritis report urinary incontinence improved following total hip arthroplasty tha however type severity remain unclear study hypothesize stress urinary incontinence sui urge urinary incontinence uui improved tha assess characteristics discuss anatomical factors related tha improved treatment outcome fifty patients underwent direct anterior approach tha evaluated type assessed using four questionnaires core lower urinary tract symptom score clss urogenital distress inventory short form udi international prostate symptom score ipss overactive bladder symptom score oabss uroflowmetry postvoid residual urine measured using ultrasound technology hip joint function evaluated using western ontario mcmaster universities osteoarthritis index womac range motion rom patients sui mixed urinary incontinence mui eight urgency urinary incontinence uui total patients better improved rate cured improved sui mui uui improvement rom significant cured improved patients stable worse patients improvement mild may added benefit undergoing tha hip joint disorders data suggest patients hip joint disorder hip joint treatment could prove also useful treatment
recent results bauer algorithms bioinformatics springer berlin cox algorithms bioinformatics springer berlin rosone sciortino nature computation logic algorithms applications springer berlin introduced external memory algorithms compute self indexes set strings mainly via computing burrows wheeler transform input strings motivations results stem bioinformatics large number short strings called reads routinely produced analyzed field fundamental problem assemble genome large set much shorter samples extracted unknown genome approaches currently used tackle problem memory intensive fact bode well ongoing increase availability genomic data data structure used genome assembly string graph vertices correspond samples arcs represent two overlapping samples paper address open problem simpson durbin bioinformatics design external memory algorithm compute string graph
studies suggested helicobacter pylori pylori infection associated insulin resistance metabolic syndrome may increase risk chronic kidney disease ckd conclusive evidence regarding association pylori infection ckd help clarify conducted cross sectional study investigate association pylori infection ckd among chinese adults total adults aged years enrolled pylori specific immunoglobulin antibody titers measured elisa ckd defined estimated glomerular filtration rate egfr less min presence proteinuria urine protein assessed using repeated dipstick method among participants study prevalence pylori infection categorical outcome prevalence decreased egfr pylori infection group higher non pylori infection group prevalence proteinuria overall ckd significantly different two groups adjusted age sex hypertension diabetes body mass index uric acid smoking drinking total cholesterol triglycerides low density lipoprotein cholesterol high density lipoprotein cholesterol odds decreased egfr proteinuria significantly different pylori positive negative subjects study find association pylori infection ckd
techniques used order promote recovery degraded areas like riverine ecosystems low impacts present fast regeneration ecological succession need human intervention necessary study use techniques contribute recovery ecosystems soil bioengineering involves use biologically active elements working soil stabilization combined inert elements concrete wood polymers geotextiles made synthetic material plant fibers work carried order evaluate planted species development endemic species ecological succession along paramopama river margin located municipality sao cristcvao sergipe state submitted soil bioengineering techniques two types geotextiles fibrax syntemax arranged two blocks three treatments tested behavior vegetation efficiency geotextiles observed period months monitored floristic survey abundance species crotalaria spectabilis calopogonium muconoides studied subsequently classified according vegetation succession stage study revealed use geotextile syntemax left bank promoted greatest abundance species resulting greater vegetation cover consequently better protection slope geotextile syntemax appropriate among tested types promote floristic recovery studied area probably similar soil climatic conditions
south africa refugee population grown considerably last decade food insecurity mental illness common developing countries relationship remains unexamined african refugee population adult refugees durban south africa interviewed using self report food insecurity hopkins symptom checklist proportion responded often true enough food eating less respectively proportion individuals significant level anxiety depressive symptomatology respectively adjusted logistic regression indicated eating enough significantly associated anxiety aor depression aor similarly eating less significantly associated anxiety aor depression aor high prevalence food insecurity relationship mental illness highlight importance addressing basic needs among population
spatial errors buffer overflows continue one dominant threats software reliability security programs presently software industry typically enforces spatial memory safety instrumentation due high overheads incurred bounds checking runtime many program inputs exercised causing input specific spatial errors undetected today commercial software paper introduces new compile time approach reducing bounds checking overheads based notion weakest precondition basic idea guard bounds check pointer dereference inside loop based guard hoisted outside loop falsehood implies absence bounds errors dereference thereby avoiding corresponding bounds check inside loop based approach applicable spatial error detection approach software hardware evaluate effectiveness approach take softbound compile time tool open source implementation low level virtual machine llvm baseline softbound adopts pointer based checking scheme disjoint metadata making state art tool providing compatible complete spatial safety new tool called wpbound refined version softbound also implemented llvm incorporating based compiler approach comprising intra interprocedural optimizations set benchmarks selected spec andmibench wpbound reduces average runtime overhead softbound reduction small code size increases
splitting water hydrogen driven solar energy considered one major strategies provide clean energy tio based photo catalysts attracted everlasting interests due low cost sources excellent stability however wide band gap limited quantum efficiency tio hinder application herein novel photocatalyst hydrogen evolution initially prepared modification tio nanosheets covalent organic polymer cop cop provide reaction active sites increasing specific surface area pristine tio nanosheets also improve light harvesting visible light region moreover suitable energy level cop provides charge transfer channels favors electron transfer greatly inhibits combination photogenerated electrons holes hybrid system particularly corresponding hydrogen production rate hybrids reaches mmol exceeds compared pristine tio nanosheets mmol elsevier ltd rights reserved
spoken words highly variable single word may never uttered way twice listeners regularly encounter speakers different ages genders accents increasing amount variation face listeners understand spoken words quickly adeptly despite variation remains issue central linguistic theory propose learned acoustic patterns mapped simultaneously linguistic representations social representations illuminate paradox results literature argue focus representations peripheral treatment word level phonetic variation consider phonetic variation fully highlight growing body work problematic current theory words different pronunciation variants recognized equally well immediate processing tasks atypical infrequent socially idealized form remembered better long term suggest perception spoken words socially weighted resulting sparse high resolution clusters socially idealized episodes robust immediate processing strongly encoded predicting memory inequality proposal includes dual route approach speech perception listeners map acoustic patterns speech linguistic social representations tandem approach makes novel predictions extraction information speech signal provides framework ask new questions propose language comprehension broadly results integration linguistic social information
spontaneous abortion miscarriage natural death embryo foetus early stages prenatal development interleukin anti inflammatory cytokine produced human cytotrophoblasts defects production result specific pathological conditions pregnancy present study aimed evaluate association polymorphism spontaneous abortions comparing foetal maternal paternal groups triad study total families spontaneous abortions families medically terminated pregnancies considered present study dna foetal tissue parental blood samples extracted genotype analysis promoter polymorphism carried amplification refractory mutation system polymerase chain reaction followed agarose gel electrophoresis statistical analysis applied test significance results statistically significant difference distribution genotypes allele two family groups among foetuses mothers paternal group showed significant difference genotype distribution cases controls conclusion gene promoter polymorphism may act major genetic regulator etiology spontaneous abortions
spontaneous splenic rupture quite rare entity may develop secondary special situations lymphoma post abdominal surgey etc literature case patient reported following thoracic surgery patient undergone right upper lobectomy pulmonary carcinoma signs acute abdomen low levels hemogram detected fifth postoperative day therefore patient underwent investigations radiological evaluation revealed splenic rupture patient operated case presented may fatal requires emergency response kept mind although extremely rare case spontaneous splenic rupture presented may fatal requires emergency response kept mind although extremely rare
sport sporting competitions play important role society high level athletes frequently held role models physical exercise classic triggering factor asthma regular physical activity essential maintain good quality life course chronic diseases asthma allergies several epidemiological surveys revealed abnormally high prevalence asthma allergies individuals involved competitive sports compared general population risk asthma varies accordance type sport practised high level athletes particularly olympic athletes practising endurance sports swimming running winter sports high risk asthma allergies however sportsmen regularly practising physical activities less intense level also subject risk allergic rhinitis occurs around twice frequently elite sportsmen author reviews physiopathological mechanisms asthnia rhinitis athletes treatment thereof particularly competitive athletes population certain number medicines ordinarily used normal subjects asthma allergic rhinitis fact list banned substances september world anti doping agency wada issued list substances since creation therapeutic use exemptions tue enabled athletes follow treatments containing banned substances however certain observers including athletes consider practice form disguised doping elsevier masson sas rights reserved
sport research activities often require graphical user interfaces gui viewing merging tagging processing data complex processing like video requires complex interfaces often guis short term research use investment creating purchasing adapting gui lost paper demonstrates auto generation gui creation tool using matlab environment gui created using text file defines component properties including figure controls callbacks auto generation gui used paper creation video digitizing interface monitoring upper arm forearm rotations cricket bowlers method simplifies creation modification guis used research authors published elsevier ltd selection peer review responsibility school aerospace mechanical manufacturing engineering rmit university
spousal revenge killers murder child apparently desire cause harm partner child parent standard explanations killings fail provide adequate solution call problem spousal revenge filicide problem killer comes take rage former partner child child dehumanized point murder although dehumanization victim acknowledged occur occurs well understood offer hypothesis killer fails represent child moral subject mind due deficit killer capacity person perception hypothesis pathological killer experiences child object rather person significant emotional value parent specificity disorder explains partner targeted explains killer able understand killing child harm parent elsevier ltd rights reserved
spreadsheets among commonly used applications data management analysis combine data processing diverse supplementary features statistics visualization reporting linear programming solvers web queries periodically downloading data external sources etc however spreadsheet paradigm computation still lacks sufficient analysis article demonstrate spreadsheet implement data transformations definable sql merely utilizing spreadsheet formulas provide query compiler translates given sql query worksheet semantics including null values thereby database operations become available users want migrate database define queries using high level language get execution plans plain vanilla spreadsheet functions available spreadsheets impose limitations algorithms one implement paper offer log sorting spreadsheet using non constant number rows surprisingly depth first search breadth first search graphs
stacks digital astronomical images combined order increase image depth variable seeing conditions sky background transparency ground based observations make coaddition process nontrivial present image coaddition methods maximize signal noise ratio optimized source detection flux measurement show purposes best way combine images apply matched filter image using point spread function psf sum images appropriate weights methods either match filter coaddition perform psf homogenization prior coaddition result loss sensitivity argue method provides increase survey speed deep ground based imaging surveys compared weighted coaddition techniques demonstrate claim using simulated data well data palomar transient factory data release present variant coaddition method optimal psf aperture photometry also provide analytic formula calculating psf photometry single multiple observations next paper series present method image coaddition limit backgrounddominated noise optimal statistical test measurement constant time image source detection shape flux measurement star galaxy separation making original data redundant provide implementation algorithms matlab
starting computational analysis brightness matching develop novel variational framework able model perceptual context driven effects may extended non physical judgments well important feature variational framework description phenomena suitable balance contrast dispersion optimal balance defined simultaneous minimization functionals characterized two terms opposition minimum reached equilibrium contrast dispersion attained show flexibility proposed framework discuss several examples functionals field color perception cognition show adherence theoretical predictions empirical results regard social cognition theories simultaneous occurrence contrast dispersion conflicts sequential models thus supporting idea concurrent presence effects judgment variational framework serve view perceptual cognitive phenomena may help deriving new constraints disambiguating alternative theories elsevier inc rights reserved
state statutes regarding best interests child bic deciding disputed custody reviewed independently coded respect three issues child preference limits parental alienation iii psychological maltreatment results revealed many states allowed child preferences considered none qualified preference undue influence occurred parental alienation term found state statutes states included least one bic factor relevant core construct parent supporting child relationship parent many states included history domestic violence child abuse three states explicitly mentioned psychological maltreatment findings highlight yet another way bics factors lack specificity ways could negatively impact children caught parents conflict
state energy soe important index batteries electric vehicles provides essential basis energy application load equilibrium security electricity improve estimation accuracy reliability soe novel multi model fusion estimation approach proposed uncertain dynamic load different temperatures main contributions work summarized follows analyzing impact estimation accuracy soe due complexity models necessity redundant modeling elaborated three equivalent circuit models selected parameters identified genetic algorithm offline linear matrix inequality lmi based infinity state observer technique applied estimate soes aforementioned models concept fusion estimation introduced estimation results derived different models merged certain weights determined bayes theorem batteries tested dynamic load cycles different temperatures validate effectiveness method results indicate estimation accuracy reliability soe elevated fusion elsevier ltd rights reserved
stationary modes possible bifurcations nonautonomous electrical circuits nonlinear resistive elements voltage current characteristic satisfied known conditions convergence investigated main result article description current modes single three phase circuit asymmetric voltage current characteristics interesting result investigation transient steady current modes nonlinear electrical circuits possibility quasi periodical process low frequency component values significance modulated modification amplitude external high frequency three phase voltage
statistics two dimensional gas model interacting lennard jones type potential considered goal examine extensivity internal energy respect potential range external white noise molecular dynamics simulation accordingly molecular dynamics simulation model designed provides reasonable evidence respect shown long range potential internal energy scales according non extensive thermodynamics expectation criteria specified besides short range case demonstrate external noise drastically modifies statistics gas makes internal energy non extensive relation non extensive parameter relaxation time noise intensity obtained elsevier rights reserved
sterile noninfected inflammation underlies pathogenesis many widespread diseases allergies autoimmune diseases evolutionarily conserved innate immune system considered play key role tissue injury recognition subsequent development sterile inflammation however underlying molecular mechanisms yet completely understood show cholesterol sulfate molecule present relatively high concentrations epithelial layer barrier tissues selectively recognized mincle clece type lectin receptor innate immune system strongly regulated response skin damage mincle activation cholesterol sulfate causes secretion range proinflammatory mediators injection cholesterol sulfate results mincle mediated induction severe local inflammatory response addition study reveals role mincle driving component pathogenesis allergic skin inflammation well established model allergic contact dermatitis absence mincle leads significant suppression magnitude skin inflammatory response assessed changes ear thickness myeloid cell infiltration cytokine chemokine secretion taken together results provide deeper understanding fundamental mechanisms underlying sterile inflammation
stigma human rights violations contribute physical mental sexual health inequities among lesbian gay bisexual transgender lgbt youth jamaica country homosexuality criminalized emergence local community based lgbt hiv agencies organizations focused promoting lgbt people health human rights scant research however focused social work education practice lgbt people jamaican context ideas action article proposes multilevel approaches empowerment oriented social work practice include psychological relational community structural dimensions hold potential address inequities article describes social structural contexts lgbt youth jamaica articulates dimensions empowerment jamaica aids support life utilized case example organization promoting multi level empowerment practice health care case example advances understanding role social workers advocating promoting health social justice lgbt people social work approaches empowerment different levels practice intervention discussed finally contributions social work education made presenting sample syllabus empowerment oriented social work course tailored working lgbt youth jamaica
stochastic process algebras combine high level system description terms interacting components rigorous low level mathematical model terms stochastic process proved valuable modelling formalisms particularly areas performance modelling systems biology however suffer problem state space explosion currently underlying stochastic process generally derived via small step operational semantics process algebra relies syntactical representation states process paper propose numerical representation schema based counting abstraction automatically detects symmetries within state space based replicated components produces compact state space moreover demonstrate amenable interpretations thus forms computational analysis enriching set qualitative quantitative measures derived model
stone columns granular column used increase load carrying capacity accelerating consolidation soft soil recently geosynthetic reinforced stone column technique developed improve load carrying capacity stone column addition reinforcement prevents lateral squeezing stone surrounding soft soil helps easy formation stone column preserve frictional properties aggregate drainage function stone column paper investigates improvement load carrying capacity isolated ordinary geotextile reinforced sand column field load tests tests performed different reinforcement stiffness diameter sand column reinforcement length results field load test indicated improved load carrying capacity geotextile reinforced sand column ordinary sand column increase load carrying capacity depends upon sand column diameter stiffness reinforcement reinforcement length also partial reinforcement length two four time sand column diameter top column found significant effect performance sand column
stormwater quality modeling arisen promising tool develop mitigation strategies aim paper assess build wash processes investigate capacity several water quality models accurately simulate predict temporal variability suspended solids concentrations runoff based long term data set markov chain monte carlo mcmc technique applied calibrate models analyze parameter uncertainty short term predictive capacity models assessed based inter intra event approaches results suggest performance wash model related dynamic pollutant transport best fit recorded first flush events assessment swmm storm water management model exponential build model reveals better performance obtained short periods build models relying antecedent dry weather period explanatory variable predict satisfactorily accumulated mass surface predictive inter event capacity swmm exponential model proves inability predict pollutograph intra event approach based data assimilation proves efficiency first flush events method interesting management practices simplicity easy implementation
streptococcus pyogenes group streptococcus gas common cause bacterial throat infections cause mild severe skin soft tissue infections including impetigo erysipelas necrotizing fasciitis well systemic fatal infections including septicaemia meningitis estimated annual incidence invasive group streptococcal infection igas industrialised countries approximately three per per year typing currently used england wales monitor bacterial strains pyogenes causing invasive infections isolated patients healthcare care workers cluster outbreak situations sequence analysis emm gene currently accepted gold standard methodology gas typing comprehensive database emm types observed superficial invasive gas strains england wales informs outbreak control teams investigations year bacterial reference department public health england phe receives approximately gas isolates england wales april bacterial reference department phe began genornic sequencing referred pyogenes isolates pertaining selected elderly nursing care maternity clusters inform future reference services outbreak analysis line modernizing strategy phe developed novel bioinformatics pipeline predict emm types using whole genome sequence wgs data efficiency method measured comparing emm type assigned method result current gold standard methodology concordance emm subtype level observed cases whereas cases concordance observed emm type level remaining cases corresponded novel types subtypes contamination laboratory sample transcription errors problems arising high sequence similarity allele sequence low mapping coverage novo assembly analysis performed two latter groups able diagnose problem possible resolve discordance respectively overall demonstrated wgs emm typing pipeline reliable robust system implemented determine emm type routine service
stress effects semiconductor devices gained significant attention semiconductor industry recent years numerical modeling often used powerful tool stress analysis semiconductor devices present nontraditional model fast stress analysis bipolar junction transistors bipolar transistors operationally devices possible speed simulation numerical model get results comparable simulation outcomes model consists complete numerical algorithm used stress analysis bipolar transistors plane existing simulators take time solve device equations throughout device contrast model optimizes solutions different regions development inclusion specific algorithms fractional starting point introduced depletion region speed process way faster computing time much higher accuracy reached time popular simulators using finite element methods naturally much slower especially high accuracy needed simulation results model match well simulation results model developed commercial technology computer aided design tcad tool validity model verified experimental results theoretical expectations well copyright john wiley sons ltd
stress exposure early life development programme individual brain physiology hypothalamic pituitary adrenal hpa axis one primary targets programming generally associated hyperactive hpa axis indicative reduced negative feedback reduced feedback efficiency usually results reduced level glucocorticoid receptor mineralocorticoid receptor within hpa axis however studies shown early life stress exposure results attenuated physiological stress response suggesting enhance feedback efficiency present study aimed determine whether early life stress long term consequences levels quail whether effects physiological response acute stress observed prenatally stressed individuals underpinned changes levels one hpa axis components determined mrna expression hippocampus hypothalamus pituitary gland quail exposed elevated corticosterone prenatal development postnatal development control individuals exposed none stressors showed prenatal stress increased ratio hippocampus expression hypothalamus expression pituitary gland postnatal stress resulted reduced expression hippocampus early life treatments permanently affected expression receptor types hpa axis regions effects prenatal stress accordance efficient negative feedback within hpa axis thus explain attenuated stress response observed birds therefore changes receptor density number consequence early life stress exposure might mechanism allows adaptive response later life stressful conditions
stress early life appointed important phenomenon onset depression poor response treatment classical antidepressants furthermore childhood trauma triggers epigenetic changes associated pathophysiology major depressive disorder mdd treatment atypical antipsychotics quetiapine exerts therapeutic effect mdd patients induces epigenetic changes study aimed analyze effect chronic treatment quetiapine depressive like behavior rats submitted maternal deprivation well activity histone acetylation enzymes histone acetyl transferases hat deacetylases hdac dna methylation dna methyltransferase enzyme dnmt prefrontal cortex pfc nucleus accumbens nac hippocampus maternally deprived rats depressive like behavior forced swimming test increase hdac dnmt activities hippocampus nac treatment quetiapine reversed depressive like behavior reduced dnmt activity hippocampus first study show antidepressant like effect quetiapine animals subjected protective effect quetiapine reducing epigenetic changes induced stress early life results reinforce important role quetiapine therapy mdd elsevier rights reserved
stress perfusion cardiovascular magnetic resonance cmr used widely adult ischemic heart disease data children limited sought evaluate feasibility accuracy prognostic value stress cmr children suspected coronary artery disease cad stress cmr reviewed two pediatric centers years using standard pharmacologic protocol wall motion abnormalities perfusion deficits late enhancement correlated coronary angiogram cag available clinical status year follow major adverse cardiovascular events mace coronary revascularization non fatal myocardial infarction death due cad recorded sixty four stress perfusion cmr studies children years using adenosine dipyridamole reviewed indications kawasaki disease post arterial switch operation post heart transplantation post anomalous coronary artery repair chest pain suspected myocarditis cad post coronary revascularization others twenty six studies performed sedation studies performed showed evidence ischemia infarction perfusion deficits late gadolinium enhancement lge without perfusion deficit compared cag positive predictive value ppv stress cmr negative predictive value npv year clinical follow ppv npv stress cmr predict mace stress perfusion cmr combination lge wall motion analysis feasible accurate method diagnosing cad children difficult cases also helps guide clinical intervention complementing conventional cag functional information
stress shielding phenomenon become major drawback use metallic biomaterials orthopaedic implants applications study alloy system investigated design develop novel low elastic young modulus based alloy implant application development application predictive modelling simulation transforming materials engineering discovery process end initio calculation used evaluate effects composition structural elastic electronic properties materials data obtained theory experiment analysed compared notable findings include low elastic young modulus values gpa gpa gpa gpa gpa alloys respectively ascribed unique elastic softening shear moduli consistency results discussed terms sensitivity physical electronic properties alloying additions thus result indicates approach enhance reduction elastic young modulus metallic biomaterials replacing commonly used high modulus materials prevent stress shielding orthopaedic implants elsevier ltd rights reserved
stresses displacements relatively short thin walled beams clamped ends subjected bending uniform loads analysed approximate solutions theory elasticity mechanics materials strength materials compared results finite element method problem clamped fixed end discussed context two approaches analytical numerical approach
stressful life events linked onset severe psychopathology endocrine dysfunction many patients moreover vulnerability later development disorders increased stress adversity development childhood neglect abuse trauma review discusses methodological features results various models stress nonhuman primates context potential relevance human psychopathology endocrine dysfunction particularly mood disorders dysregulation hypothalamic pituitary adrenocortical hpa system models typically examined effects stress animals behavior endocrine function primarily hpa hypothalamic pituitary gonadal systems cases immune status manipulations relocation removal animal current social group alternatively formation new social group adverse effects outcome measures may either transient persistent depending species sex experimental conditions social primates may also experience significant stress associated rank group dominance hierarchy finally stress prenatal development early postnatal period may long lasting neurobiological endocrine effects manifest altered ability cope behaviorally physiologically later challenges whereas early exposure severe stress usually results deficient coping abilities certain kinds milder stressors promote subsequent resilience animal conclude studies stress nonhuman primates model many features stress exposure human populations studies play valuable role helping elucidate mechanisms underlying role stress human psychopathology endocrine dysfunction
stroke heterogeneous syndrome determining risk factors treatment depends specific pathogenesis stroke risk factors stroke categorized modifiable nonmodifiable age sex race ethnicity nonmodifiable risk factors ischemic hemorrhagic stroke hypertension smoking diet physical inactivity among commonly reported modifiable risk factors recently described risk factors triggers stroke include inflammatory disorders infection pollution cardiac atrial disorders independent atrial fibrillation single gene disorders may cause rare hereditary disorders stroke primary manifestation recent research also suggests common rare genetic polymorphisms influence risk common causes stroke due risk factors specific stroke mechanisms atrial fibrillation genetic factors particularly environmental interactions may modifiable previously recognized stroke prevention generally focused modifiable risk factors lifestyle behavioral modification dietary changes smoking cessation reduces stroke risk also reduces risk cardiovascular diseases prevention strategies include identifying treating medical conditions hypertension diabetes increase stroke risk recent research risk factors genetics stroke identified risk stroke also identified ways target risk populations stroke prevention
structural damage due excessive loading environmental degradation typically occurs localized areas absence collapse leads local stiffness reductions prior information spatial sparseness structural damage associated stiffness loss exploited hierarchical sparse bayesian learning sbl framework goal reduce ill conditioning stiffness loss inversion problem damage detection previously proposed sbl approach establish probability localized stiffness reductions caused damage using noisy incomplete modal data possible damage excellent performance achieved introducing sparseness damage pattern demonstrated using synthetic data small modeling errors research rigorous formulation along corresponding efficient scale invariant sbl algorithm developed algorithm first applied synthetic data real vibration response steel frame test structure large modeling errors data phase simulated experimental benchmark studies sponsored iasc asce task group structural health monitoring results show even real data proposed method reliably detect locate assess damage benchmark structure inferring substructure stiffness losses using identified modal parameters calibration monitoring stages occurrence missed false damage alerts effectively suppressed show new algorithm gives better performance previous sbl method real data case significant modeling error several appealing features method summarized end paper published elsevier ltd
structural health monitoring key factor life cycle management infrastructures truly distributed fiber optic sensors able provide relevant information large structures bridges dikes nuclear power plants nuclear waste disposal facilities sensing chain includes optoelectronic unit sensing cable made one optical fibers new instrument based optical frequency domain reflectometry ofdr enables perform temperature strain measurements centimeter scale spatial resolution hundred meters level precision equal strain degrees several sensing cables designed different materials targeting last decades concrete aggressive environment ensure optimal transfer temperature strain concrete matrix optical fiber tests carried embedding various sensing cables plain concrete specimens representative scale reinforced concrete structural elements measurements performed ofdr instrument meanwhile mechanical solicitations imposed concrete element preliminary experiments promising since measurements performed distributed sensing system comparable values obtained conventional sensors used civil engineering strength materials modelling moreover distributed sensing system makes possible detect localize cracks appearing concrete mechanical loading
structural health monitoring crucial protect lives asset management classical sensors low durability low sensitivity high cost limit use development smart cement based materials construction industry important task study six different cement based mixtures designed five mixtures steel fiber inclusions three samples mixture cast cured thus samples prepared samples tested split tensile test simultaneous split tensile test electrical potential measurements conducted use split tensile test determining self sensing properties cement based composites achieved first time study correlations electrical resistance change tensile strain determined performance measures gage factor linearity strain sensor investigated cement based composites gage factors high obtained highest gage factor reported literature gage factor cement based composite almost times gage factor metal strain gages gage factor variations electrical resistance gage factor linearity correlation coefficient best fit line electrical resistance change versus strain data respect fiber volume fraction discussed observations encouraging research development smart cement based materials sense strain damage elsevier ltd rights reserved
structural optimization shown efficient effective method obtain optimal design balancing competing objectives however literature optimization structures subject random excitation sparse study proposes performance based optimization approach nonlinear structures subject stochastic dynamic excitation optimization procedure formulated multi objective problem considering various performance objectives excitation modeled zero mean filtered white noise combined nonlinear equations motion structure create augmented state space representation system optimization objectives defined terms variance stationary structural responses obtained via equivalent linearization thus stochastic optimization problem converted deterministic counterpart numerical examples provided demonstrate efficacy proposed approach three levels seismic magnitudes low level frequent earthquake medium intensity earthquake high intensity earth quake investigated seismic magnitude two performance objectives considered first performance objective considers serviceability seeking minimize floor acceleration response second performance objective considers structural safety seeks minimize interstory drift response pareto optimal fronts calculated illustrate intrinsic tradeoffs serviceability safety designs subject seismic magnitudes elsevier ltd rights reserved
structural temperature important form loading bridges particularly long span steel structures study temperature distribution humber bridge united kingdom investigated using numerical simulation field measurements two dimensional fine finite element model typical section box girder long span suspension bridge constructed time dependent thermal boundary conditions determined using field meteorological measurements external surface heat convection coefficients varying according differing local wind speeds experience preanalysis adopted determine initial thermal condition model transient heat transfer analysis performed time dependent temperature distribution bridge obtained leading numerical temperature data different locations different times good agreement measured counterparts vertical transversal temperature differences ttds box girder also investigated measured numerical results show transversal temperature variation across streamlined girder significant effects box girder shape pavement upper webs bridge orientation ttd finally investigated american society civil engineers
structure determination parameter identification multivariate systems crucial rather difficult issues system identification due explosive growth process data along scale increase industrial processes directional links variables complex processes often undistinguishable indispensable model structure determination often assumed known beforehand identification methods article new modelling approach developed simultaneously estimate model parameters structures including model orders well directional links different process variables multivariate systems vector auto regressive var form utilized model formulation algorithm key technique lies constructing interleaved information matrix respect multiple model structure formulated var representation utilizing upper diagonal factorization parameter estimates path models orders zero well corresponding cost function values obtained simultaneously effectiveness proposed method demonstrated via numerical example distillation column system
structured light depth sensors widely used simplicity design ability process depth data minimal computational expense certain light coding methods however lead loss information well inhomogeneous depth errors depend composition properties scene results reduction potential accuracy model based pose estimation methods operate depth images subsequently transformed three dimensional point clouds popular class point set registration psr methods therefore formulate asymptotically optimal maximum likelihood estimation mle method operates directly raw infrared images proposed slir mle method maximizes likelihood measured image pose region given object model sensor model calibrated speckle thermal noise distributions also formulate method compute fisher information contained image resulting cramer rao bound crb unbiased pose estimator unique sensor measurement data slir mle shown nearly achieve calculated crb kinect sensor operating informative raw images furthermore method shown outperform two cutting edge psr methods order magnitude respective mean square errors
student course planning advising universities important process ensure students fulfill degree requirements university structured way without encountering unnecessary lengthy delays united arab emirates university uaeu one institution student register courses one advanced adequate registration systems however students faced problems need proper advising system well need seeking proper advising knowledge based course planning system kbcps software package devised suit course planning needs electrical engineering department uaeu software developed using java computer programming language system guide students selecting suitable five seven courses register next subsequent semesters outcome course selections next remaining semesters stored file help students registration system
students regularly struggle mathematical tasks particularly concerning non routine problems geometry although educators would like learners transfer knowledge non routine real life situations students run number difficulties goal exploratory study analyze three participants problem solving processes dynamic geometry software dgs therefore gain insights dgs used support solving non routine geometry problems viewed dgs cognitive tool enhance reorganize problem solving process three participants different phases educational career mathematics mathematics education bachelor master doctoral student one problem land boundary problem timss video study discussed problem participants straighten bent fence two farmers land farmer would keep amount land three participants solved problem used computer based problem solving tool differently dgs allowed supported participants discover new methods thinking unanticipated ways using also inhibited problem solving processes development tool dependency different use dependent presence managerial decisions ability manage different resources problem solving experience based findings make recommendations technology embedded problem solving emphasis importance appropriate tool use educational settings offer teaching methods may worthwhile research
studied paper dimensional nonlinear schrodinger equation group velocity dispersion fiber gain loss nonlinearity coefficient functions describes evolution slowly varying wave packet envelope inhomogeneous optical fiber hirota method symbolic computation bilinear form dark multi soliton solutions certain variable coefficient constraint derived interactions different type dark two solitons asymptotically analyzed presented velocities amplitudes two linear type dark solitons change interaction two parabolic type dark solitons propagating opposite directions change directions interaction interaction two periodic type dark solitons also presented interactions linear parabolic periodic type dark two solitons elastic
studies demonstrated personality traits differ schizophrenia patients family members compared controls suggesting familial risk study evaluated personality traits family study schizophrenia well relationship personality traits symptoms social functioning schizophrenia patients thirty two schizophrenia patients adult non psychotic relatives community controls completed dimensional assessment personality pathology basic questionnaire dapp schizophrenia patients differed many dimensions dapp compared controls relatives affective lability anxiousness callousness conduct problems cognitive dysregulation identity problem intimacy insecure attachment low affiliation narcissism oppositionality restricted expression self harm submissiveness suspiciousness differences found relatives controls furthermore schizophrenia patients associations found personality particularly general symptoms well social functioning personality traits conceptualized extended phenotype schizophrenia patients
studies examined differences sociodemographic clinical characteristics patients long acting injectable lai versus oral medications however studies focus specifically patients lais would clearly indicated performed chart review patients schizophrenia schizoaffective disorder patients categorized indication lai basis adherence history patients lai indicated prescribed discharge compared similar patients lai prescribed charts reviewed consisting unique patients judged indication lai discharged lai multiregression model african american residing psychiatric residence previous history lai trial treated higher antipsychotic dose predictive lai prescription important focus population likely receive lai indications treatment
studies shown false memories implanted via innocuous suggestions memories play role shaping people subsequent attitudes preferences current study explored whether participants received false suggestion become ill drinking particular type alcohol would increase confidence event occurred whether new found belief would subsequently affect alcohol preferences results indicated participants received suggestion gotten sick drinking rum vodka age reported increased confidence suggested experience occurred moreover participants received false alcohol suggestion also showed strong trend report diminished preference specified type alcohol false suggestion implantation false memory related one past drinking experiences may influence current drink preferences could important avenue exploration development alcohol interventions published elsevier
studies shown oxidative stress involved pathophysiology bipolar disorder suggested omega omega fatty acids fundamental maintaining functional integrity central nervous system animal model used study displayed fenproporex induced hyperactivity symptom similar manic results showed administration fenproporex prevent treatment protocol increased lipid peroxidation prefrontal cortex hippocampus striatum omega fatty acids alone prevented change prefrontal cortex hippocampus whereas administration omega fatty acids vpa prevented lipoperoxidation analyzed brain areas administration omega fatty acids prevented increase prefrontal cortex striatum moreover superoxide dismutase sod activity decreased striatum prevention treatment administration omega fatty acids alone combination vpa partially prevented inhibition hand reversal treatment protocol administration fenproporex increased carbonyl content prefrontal cortex hippocampus striatum prefrontal coxter administration omega fatty acids alone combination vpa reversed change whereas hippocampus striatum omega fatty acids alone combination vpa reversed effect additionally administration fenproporex resulted marked increase tbars hippocampus striatum omega fatty acids alone combination vpa reversed change finally fenproporex administration decreased sod activity prefrontal cortex hippocampus striatum omega fatty acids combination vpa reversed change prefrontal cortex striatum administration omega fatty acids reversed inhibition hippocampus striatum conclusion results support studies showing importance omega fatty acids brain potential fatty acids aid treatment
studies genetics serum cytokines autoimmune illnesses suggest immune related abnormalities involved disease process schizophrenia furthermore direct evidence cortical immune activation including markedly elevated levels many immune related markers reported prefrontal cortex multiple cohorts schizophrenia subjects within prefrontal cortex schizophrenia deficits basilar dendritic spines layer pyramidal neurons disturbances inhibitory inputs pyramidal neurons also commonly reported interestingly microglia resident immune related cells brain also regulate excitatory inhibitory input pyramidal neurons consequently review describe cytological molecular evidence immune activation reported brains individuals schizophrenia potential links immune related disturbances previously reported disturbances pyramidal inhibitory neurons disorder finally discuss role activated microglia may play connecting observations potential therapeutic treatment targets schizophrenia elsevier inc rights reserved
studies hyperpolarized xenon media liquid crystals cell suspensions demand applications ranging biomedical imaging materials engineering hindered inability bubble desired media result viscosity perturbations caused bubbles herein device reported reliably used dissolve viscous aqueous organic samples without bubbling method robust requires small sample volumes compatible existing nmr hardware made readily available materials experiments show introduced viscous aligned media without disrupting molecular order detected dissolved xenon aqueous liquid crystal disrupted shear forces bubbling observed liquid crystal phase transitions mbba tool allows entirely new class samples investigated hyperpolarized gas nmr spectroscopy
studies women experiences correspondence internet brides conducted used survey instruments interviews tests created normed populations study specifically examined experiences filipina women utilized international dating agency venues meet husbands attempted phenomenologically extract essence population experiences correspondence internet brides phenomenological analysis conducted experiences seven filipina correspondence internet brides forty four categories determined collapsed eight broad themes connection filipino culture acculturating culture negotiating self importance family correspondence experiences connecting husband resilience betrayal importance one socioeconomic status women experiences comparable previous literature including dichotomy gender roles need maintain harmony marital relationships maintaining sense independence
studies show development perfectionism adolescence associated psychologically controlling parenting current study extends research area examining relationship specific aspect psychologically controlling parenting parental conditional regard two dimensions perfectionism self critical perfectionism narcissistic perfectionism three hundred sixteen adolescents age years completed standardised questionnaire structural equation modelling revealed self critical perfectionism narcissistic perfectionism positively predicted parental conditional regard findings first suggest parent socialization characterised guilt inducement love withdrawal may common development two distinct dimensions perfectionism elsevier ltd rights reserved
studies suggest patients subclinical hypothyroidism sympathovagal imbalance could lead slower heart rate response transition rest exercise thus objective study investigate behavior kinetics patients transition rest exercise study included women thyroid stimulating hormone tsh free thyroxine euthyroid women tsh groups matched physical activity menopausal status age kinetics obtained course constant load exercise min cycle ergometer quantified mean response time mrt equivalent time taken reach steady state patients showed slower kinetics control group mrt mrt shown correlate level physical activity subjective perception exertion end exercise concluded patients slower kinetics transition rest exercise compared euthyroid women impairment associated lower levels physical activity new noteworthy subclinical hypothyroidism patients slower heart rate kinetics transition rest exercise performing constant load exercise
studies using retrospective self report proxies nonsuicidal self injury nssi lab shown nssi often preceded intense negative emotions followed decrease negative emotions tension suggesting emotion regulation function nssi investigate emotion regulation function nssi ecologically valid way used experience sampling methods examine temporal relationship nssi behavior emotional experiences throughout day inpatients currently staying psychiatric hospitals nssi especially prevalent severe patients borderline personality disorder bpd focused patients high levels bpd symptomatology results confirmed high levels negative emotion prospectively predicted higher probability engaging nssi next time interval however occurrence nssi related concurrent increases negative emotion decreases positive emotion even prospectively predicted increase negative emotion consecutive time interval preliminary results show time scale hours instead resulting emotional relief nssi seems associated increase negative emotionality shedding light cyclic nature nssi general scientific summary nonsuicidal self injury nssi often considered serving emotion regulation function leading decrease negative feelings show nssi indeed preceded elevated levels negative emotionality fact followed increase decrease negative emotion within timespan hours inpatients borderline personality disorder features shedding light cyclic nature nssi
study design cross sectional observational study utilizing national ambulatory national hospital ambulatory medical care surveys objective aim study characterize national physical therapy referral trends primary care provider pcp visits united states summary background data despite guidelines recommending initial management low back pain lbp national referral rates remain low methods race ethnicity age payer type referral rates collected patients aged years visiting pcps associations among demographic variables referral determined using logistic regression results estimated million visits lbp leading million referrals average proportion pcp visits associated referrals remained stable odds ratio confidence interval despite prior finding increasing number visits associated opioid prescriptions timeframe lower referral rates observed among visits patients insured medicaid medicare furthermore visits associated referrals likely associated opioid prescriptions conclusion although therapies delivered pts promoted first line treatment lbp referral rates remain low also exist disparately lower referral rates populations restrictive health plans simultaneous opioid prescription findings provide broad overview prescription trend isolate concerning associations requiring explorations
study design retrospective study summary background data complications bone cement used vertebroplasty kyphoplasty procedures received increasingly attention especially bone cement volume objective aim study retrospectively assess relationship bone cement volume fraction adjacent vertebral fracture avf unilateral percutaneous kyphoplasty pkp materials methods patients single level osteoporotic vertebral compression fracture ovcf surgically treated unilateral pkp completed month follow hospital according new ovcf divided groups avf group non avf group normal group new ovcf basis value plain radiography cement volume fraction vertebral body calculated cement leakage bone mineral density visual analog scale cobb angle preoperative postoperative analyzed results follow patients new ovcf others normal fifty two cases avf non avf cement volume fraction avf group non avf group normal group respectively confidence interval volume fraction respectively avf group showed higher cement volume fraction groups patients cement leakage avf group non avf group normal group avf group showed higher cement leakage compared avf group normal group non avf group lower bone mineral density preoperation groups reported significantly improved visual analog scale scores cobb angle day surgery however significant difference groups conclusions unilateral pkp effective safe procedure patients ovcf however cement volume determined terms vertebral body fraction obtain favorable outcome risk avf cement leakage increase obviously cement volume fraction increased recommend bone cement volume fraction one fourth suitable unilateral pkp
study objective design unintended pregnancy rates united states remain high among adolescents emergency contraception provides option pregnancy prevention unprotected sex better define population adolescents request use pills performed post hoc analysis counter simulation study pills setting teen reproductive health clinics cities participants adolescents ages years requested interventions single tablet levonorgestrel main outcome measures calculated correlations age baseline sexual contraceptive behaviors tests used compare behaviors first time repeat users results overall commonly reported contraceptive methods ever used condoms oral contraceptives none withdrawal common method ever used age group method year olds condom year olds percentage participants never used contraception requesting decreased age yearolds year olds first time users likely report previous contraceptive use compared repeat users regardless age commonly reported reason requesting nonuse contraceptive method unprotected sex conclusion adolescents requested commonly reported ever use contraceptive methods rely user adherence method younger adolescents likely older adolescents used previous method provision presents opportunity provide education access highly effective long term contraceptive methods
study objective administration intranasal dexmedetomidine sedation comfortable effective children afraid needles offers efficient sedation similar intravenous administration performed systematic review meta analysis evaluate clinical effects pre procedural administration intranasal dexmedetomidine design identified randomized controlled trials rcts compared intranasal dexmedetomidine administration administration methods various sedatives placebo medline embase cochrane koreamed hand searches trial registries setting pediatrics underwent interventional procedures surgeries patients children age interventions studies included compatible criteria dexmedetomidine administered intranasally measurements pooled data sedation status primary outcome considered behavioral score blood pressure heart rate side effects secondary outcomes risk ratio standardized mean difference smd confidence intervals cis calculated dichotomous continuous outcomes respectively main results meta analysis included rcts smd sedative effects intranasal dexmedetomidine random continuous outcomes unsatisfactory patient outcome random dichotomous outcomes compared intranasal saline smd sedative effects intranasal dexmedetomidine random continuous outcomes random dichotomous outcomes compared per benzodiazepines conclusions review suggests intranasal dexmedetomidine associated better sedative effects oral benzodiazepines without producing respiratory depression significantly delayed onset effects elsevier inc rights reserved
study objective research examined impact daylight exposure health office workers perspective subjective well sleep quality well actigraphy measures light exposure activity sleep wake patterns methods participants included workers working windowless environments comparable workers workplaces significantly daylight windowless environment defined one without windows one workstations far away windows without exposure daylight well office workers measured short form sleep quality measured pittsburgh sleep quality index psqi addition subset participants workers windowless environments workers workplaces windows actigraphy recordings measure light exposure activity sleep wake patterns results workers windowless environments reported poorer scores counterparts two dimensions role limitation due physical problems vitality well poorer overall sleep quality global psqi score sleep disturbances component psqi compared group without windows workers windows workplace light exposure workweek trend toward physical activity longer sleep duration measured actigraphy conclusions suggest architectural design office environments place emphasis sufficient daylight exposure workers order promote office workers health well
study objective examine differences factors associated contraceptive use younger older adolescent age groups previously well described design age group specific analyses performed cross sectional survey data identify factors associated contraceptive use last sex among younger year old older year old sexually active african american female adolescents interaction analyses used assess whether associations differed age setting adolescent reproductive health clinic atlanta georgia participants sexually active african american female adolescents years age interventions intervention tested cross sectional design main outcome measure self reported contraceptive use recent vaginal sex male partner results prevalence contraceptive use last sex identical groups however factors associated contraceptive use differed according age factor associated contraceptive use age groups involvement decisions sexual health recent relationship associations factors contraceptive use significantly differed according age history sexually transmitted infection age difference partner discussion condoms partner concurrent partners important factors among younger adolescents worry pregnancy discussion birth control partner important among older adolescents conclusion factors associated contraceptive use last sex differ according adolescent age considered designing counseling interventions teens well research
study objective determine injury illness patterns occurrence rates wilderness recreation design prospective injury illness surveillance study setting wilderness areas throughout western hemisphere type participants students instructors national outdoor leadership school courses five year period main results single fatality occurred resulting death rate per person days exposure injuries occurred rate per person days exposure sprains strains soft tissue injuries accounted injuries illness rate per person days exposure sixty percent illnesses due nonspecific viral illnesses diarrhea hygiene appeared significant impact incidence illnesses thirty nine percent injuries illnesses required evacuation per person days exposure conclusion injury illness patterns indicate wilderness medical efforts concentrate wilderness hygiene management musculoskeletal injuries soft tissue wounds data also indicate wilderness activities conducted relatively safely decision participate individualized understanding risks versus benefits
study objectives determine effects yoga aerobic exercise compared usual activity objective assessments sleep midlife women methods secondary analyses randomized controlled trial menopause strategies finding lasting answers symptoms health msflash network conducted among late transition postmenopausal women aged hot flashes women randomized yoga supervised aerobic exercise usual activity mean coefficient variation change actigraph sleep measures intervention group compared usual activity group using linear regression models results baseline values primary sleep measures entire sample mean total sleep time tst min mean wake sleep onset waso min mean waso mean number long awakenings min changes actigraphic sleep outcomes baseline weeks small none differed groups exploratory analysis women baseline pittsburgh sleep quality index higher significantly reduced tst following yoga compared usual activity conclusions study adds currently scant literature objective sleep outcomes yoga aerobic exercise interventions population although small effects self reported sleep quality previously reported interventions statistically significant effects actigraph measures except potentially improved sleep stability yoga women poor self reported sleep quality
study objectives determine association common genetic variation clock gene pathway objectively measured actigraphic sleep activity rhythm traits design genetic association study two population based cohorts elderly participants study osteoporotic fractures sof osteoporotic fractures men mros study setting population based participants sof participants female mean age years mros participants male mean age years actigraphy genotype data interventions measurements results common genetic variation candidate genes captured using single nucleotide polymorphisms snps sleep activity rhythm traits objectively measured using wrist actigraphy region high linkage disequilibrium chromosome containing candidate gene gnb allele allele significantly associated higher wake sleep onset meta analysis add add lower lrrc gene expression mros participants snps arntl npas genes coding binding partners associated later sleep wake onset time sleep onset time arntl npas wake onset time snp interaction significant sleep onset time int wake onset time int snp association clock gene replicated mros cohort associated sleep duration previously reported study cluster analysis identified four clusters genetic associations conclusions findings support role common genetic variation clock genes regulation inter related sleep traits elderly
study objectives evaluate novel sleep education program low income preschool children families design randomized trial educational intervention setting community based participants head start preschool families greater lansing detroit michigan interventions classrooms head start sites randomized intervention group prompt intervention versus control group delayed intervention parents attended one time min sleep education program preschoolers received total min classroom sleep curriculum measurements parent knowledge attitudes self efficacy beliefs assessed primary outcomes min sleep intervention immediately postintervention approximately postintervention parents reported child bedtimes wake times day sleep diaries baseline follow average weeknight sleep durations bedtimes served secondary outcomes results linear mixed models showed time treatment effect parents knowledge attitudes self efficacy beliefs improvements found immediately postintervention retained follow children intervention group improved weeknight sleep duration follow min hours baseline compared controls versus baseline difference groups children show statistically significant improvements bedtime conclusions educational interventions early childhood effect parents sleep knowledge attitudes self efficacy children sleep behavior however repeated exposure new information may important parents well children
study objectives work family conflict threat healthy sleep behaviors among employees study aimed examine work family conflict demands work interfere one family personal life wtfc family work conflict demands family personal life interfere work ftwc associated several dimensions sleep among information technology workers methods employees firm provided self reports sleep sufficiency feeling rested upon waking sleep quality sleep maintenance insomnia symptoms waking middle night early morning last month also provided week actigraphy nighttime sleep duration napping sleep timing novel sleep inconsistency measure analyses adjusted work conditions job demands decision authority schedule control family supportive supervisor behavior household sociodemographic characteristics results employees experienced higher wtfc reported less sleep sufficiency poorer sleep quality insomnia symptoms higher wtfc also predicted shorter nighttime sleep duration greater likelihood napping longer nap duration furthermore higher wtfc linked greater inconsistency nighttime sleep duration sleep clock times whereas higher ftwc associated rigidity sleep timing mostly driven wake time conclusions results highlight unique associations wtfc ftwc employee sleep independent work conditions household sociodemographic characteristics novel methodological approach demonstrates differential associations wtfc ftwc inconsistency sleep timing given strong associations wtfc poor sleep future research focus reducing wtfc
study objectivethe food drug administration approval use apixaban patients creatinine clearance crcl minute receiving dialysis based pharmacokinetic data clinical trials apixaban excluded patients crcl thus objective study evaluate safety effectiveness apixaban versus warfarin patients severe renal impairment designretrospective matched cohort study settingcommunity hospital patientsa total adults received least one dose apixaban patients warfarin patients hospitalized january december crcl received peritoneal dialysis hemodialysis included patients taking warfarin therapeutic international normalized ratio admission matched consecutively fashion chronologic order patients taking apixaban based renal function indication anticoagulation measurements main resultsthe primary outcome major bleeding secondary outcomes included composite bleeding major bleeding clinically relevant nonmajor bleeding minor bleeding addition documented ischemic stroke recurrent venous thromboembolism nonsignificant difference occurrence major bleeding composite bleeding observed patients received apixaban compared received warfarin respectively occurrence stroke similar groups group recurrent venous thromboembolism events noted either group study period conclusionapixaban appears reasonable alternative warfarin patients severe renal impairment
submerged aquatic vegetation affects flow sediment ecological processes within rivers quantifying effects key effective river management despite wealth research vegetated flows detailed flow characteristics around real plants natural channels still poorly understood present new methodology representing vegetation patches within computational fluid dynamics cfd models vegetated channels vegetation represented using mass flux scaling algorithm mfsa drag term within reynolds averaged navier stokes equations account mass momentum effects vegetation respectively model applied using three different grid resolutions using time averaged solution methods compared field data results show model reproduces complex spatial flow heterogeneity within channel increasing resolution leads enhanced model accuracy future applications model prediction channel roughness sedimentation key eco hydraulic variables presented likely valuable informing effective river management authors earth surface processes landforms published john wiley sons ltd
sudden death syndrome sds complex two diseases soybean glycine max caused soil borne pathogenic fungus fusarium virguliforme root rot leaf scorch diseases result significant yield losses worldwide partial sds resistance demonstrated multiple soybean cultivars study aimed highlight proteomic changes soybean roots identifying proteins differentially expressed near isogenic lines nils contrasting rhg rfs locus partial resistance susceptibility sds two dimensional gel electrophoresis resolved approximately spots gel spots significant difference abundance fold picked trypsin digested analyzed using quadruple time flight tandem mass spectrometry several spots contained one protein distinct proteins identified overall functional analysis performed categorize proteins depicted major pathways altered fungal infection include disease resistance stress tolerance metabolism first report identifies proteins whose abundances altered response fungal infection leading sds results provide valuable information sds resistance soybean plants plant partial resistance responses general importantly several identified proteins could good candidates development sds resistant soybean plants
suicidal thoughts behaviors stbs major public health problems declined appreciably several decades one first steps improving prevention treatment stbs establish risk factors longitudinal predictors provide summary current knowledge risk factors conducted meta analysis studies attempted longitudinally predict specific stb related outcome included studies total risk factor effect sizes past years present random effects meta analysis produced several unexpected findings across odds ratio hazard ratio diagnostic accuracy analyses prediction slightly better chance outcomes broad category subcategory accurately predicted far chance levels predictive ability improved across years research studies rarely examined combined effect multiple risk factors risk factors homogenous time broad categories accounting nearly risk factor tests average study nearly years long longer studies produce better prediction homogeneity existing research means present meta analysis could speak stb risk factor associations within narrow methodological limits limits allowed tests approximate stb theories present meta analysis accordingly highlights several fundamental changes needed future studies particular findings suggest need shift focus risk factors machine learning based risk algorithms
suitable maintenance rehabilitation repair methods long span bridges decided based purposes evaluated carrying close inspection observation study deals rehabilitation method applicability long span bridge fatigue crack stinger bearing connection plate replacing line type contact bearing systems pot bearings proposed rehabilitation method stop fatigue cracking reduce local stress fatigue cracked connection plates improve structural behaviors main suspension bridge members thus stringer bearing connection specimen fabricated gouging bracket installation simulated replacing deteriorated bearing system new bearing system results gouging bracket installation test applicability rehabilitation method change works verified addition structural responses loading tests compared finite element analysis terms changes bearing conditions deformations stringer end beam improved local stress displacement fatigue cracked connection plate reduced owing bearing system replacement therefore replacement bearing system improve stress level stop fatigue cracking fatigue cracked connection plates suspension bridges addition results provide basic information rehabilitation method involving replacing bearing systems bridges line type contact bearings elsevier ltd rights reserved
summary main aspect paper show stability linear time variant systems estimated location eigenvalues purpose two simple time variant electrical circuits presented constant eigenvalues shown time variant circuits asymptotically stable although positive eigenvalue circuit unstable despite negative eigenvalues idea behind suited time variant state transformation linear time invariant system electrical interpretation systems state transformations allows energetic evaluation electrical point view even though analytical solution necessarily known copyright john wiley sons ltd
supermarkets nowadays equipped barcode scanners speed checkout process nevertheless agricultural products pre packaged thus must weighted development produce recognition system based computer vision could help cashiers supermarkets pricing weighted products work proposes hybrid approach object classification attribute classification produce recognition system involves cooperation integration statistical approaches semantic models integration attribute learning produce recognition system proposed due fact attribute learning emerged promising paradigm bridging semantic gap assisting object recognition many fields study could tackle problems occurred less training data available less samples per class experiments show correct classification rate hybrid approach training examples respectively higher individual classifiers well balanced specificity sensitivity score achieved hybrid approach produce type
super saturated salt solutions used control relative humidity infer hydration water uptake loss behaviour three needle punched geosynthetic clay liners gcls respect time conditions free swell kpa applied stress shown applied stress play key role hydration behaviour time gcl specimens equilibrium water vapour also observed water uptake loss affected bentonite form powdered granular mineralogy bentonite however effect gcl structure difference geotextiles bonding needle punched fibres carrier geotextile hydration behaviour gcls similar form bentonite significant effect gcl structure became apparent gcls results presented study used better assess hydration gcls field applications waste containment liners cover systems different overburden stress conditions
super simple designs used provide samples maximum intersection small possible statistical planning experiments also applied cryptography codes paper super simple pairwise balanced designs block sizes investigated proved necessary conditions existence super simple lambda pbd lambda sufficient three possible exceptions elsevier rights reserved
supervised classification methods widely used hyperspectral remote sensing image analysis however require large number training samples guarantee good performance costs large amount time human labor motivating researchers reuse labeled samples mass pre existing related images transfer learning methods adapt knowledge existing images solve classification problem new yet related images drawn increasing interest remote sensing field however existing methods field require images share dimensionality prevents practical application paper focuses transfer learning problem heterogeneous spaces dimensions different propose novel iterative reweighting heterogeneous transfer learning irhtl framework iteratively learns common space source target data conducts novel iterative reweighting strategy reweight source samples iteration heterogeneous data first mapped common space two projection functions based weighted support vector machine second based common subspace source data reweighted using iterative reweighting strategy reused transferring according relative importance experiments undertaken three data sets confirmed effectiveness reliability proposed irhtl method
support settlement cable slippage long span suspension bridge may occur subjected extreme events evaluation effects support settlement cable slippage remaining capacity becomes important making retrofitting decision however difficult conduct evaluation prototype bridge paper therefore presents experimental numerical studies examine effects support settlement cable slippage structural performance long span suspension bridge testbed include laboratory based model updated finite element model four support settlement cases experimentally studied two anchorage settlements two tower settlements main cable slippage top towers investigated experimentally two opposite directions support settlement cases cable slippage cases also simulated using corresponding model results compared tests finally numerical studies conducted investigate cable slippage caused large support settlement results show experimental numerical simulation using testbed effective way assess effects support settlement cable slippage long span suspension bridges
suppose client stores elements hash table outsourced untrusted server address problem authenticating hash table operations goal design protocols capable verifying correctness queries updates performed server thus ensuring integrity remotely stored data across entire update history solutions authentication problem allow client gain trust operations performed faulty even malicious server lies outside administrative control client present two novel schemes implement authenticated hash table authenticated hash table exports basic hash table functionality maintaining dynamic set elements coupled ability provide short cryptographic proofs given element member current set employing efficient algorithmic constructs cryptographic accumulators core security primitive schemes provide constant proof size constant verification time sublinear query update time strictly improving upon previous approaches specifically first scheme based rsa accumulator server able construct non membership proof constant time perform updates time fixed constant variation scheme achieves different trade offering constant update time query time second scheme uses accumulator based bilinear pairings achieve update time server keeping complexities constant variation scheme achieves time queries constant update time experimental evaluation solutions shows practicality
suppose assess joint distribution random vector one selects kernels regarded possible conditional distribution given equal compatible exists joint distribution conditionals similarly improperly compatible obtained according usual rule improper distribution place probability distribution paper compatibility improper compatibility characterized assumptions functional form characterization applies particular belongs one parameter exponential family special attention paid gaussian conditional autoregressive models elsevier rights reserved
surface flow types sfts advocated ecologically relevant hydraulic units often mapped visually bankside characterize rapidly physical habitat rivers sft mapping simple non invasive cost efficient however also qualitative subjective plagued difficulties recording accurately spatial extent sft units quantitative validation underlying physical habitat parameters often lacking consistently differentiate sfts investigate explicitly accuracy reliability statistical separability traditionally mapped sfts indicators physical habitat using independent hydraulic topographic data collected three surveys reach river arrow warwickshire england also explore potential novel remote sensing approach comprising small unmanned aerial system suas structure motion photogrammetry sfm alternative method physical habitat characterization key findings indicate sft mapping accuracy highly variable overall mapping accuracy exceeding results analysis similarity tests found strong differences exist sft pairs leads question suitability sfts characterizing physical habitat river science management applications contrast suas sfm approach provided high resolution spatially continuous spatially explicit quantitative measurements water depth point cloud roughness microscale spatial scales data acquired rapidly inexpensively provide new opportunities examining heterogeneity physical habitat range spatial temporal scales whilst continued refinement suas sfm approach required propose method offers opportunity move away broad mesoscale classifications physical habitat spatial scales towards continuous quantitative measurements continuum hydraulic geomorphic conditions actually exists microscale copyright john wiley sons ltd
surrogate assisted global optimization gaining popularity similarly modern advances computing power increasingly rely parallelization rather faster processors paper examines methods used take advantage parallelization surrogate based global optimization key issue focused review different algorithms balance exploration exploitation papers surveyed adaptive samplers employ gaussian process kriging surrogates allow sophisticated approaches balancing exploration exploitation even allow develop algorithms calculable rate convergence function number parallel processors addition optimization based adaptive sampling surrogate assisted parallel evolutionary algorithms also surveyed beyond review present state art paper also argues methods provide easy parallelization like multiple parallel runs methods rely population designs diversity deserve attention
sustainability science solution oriented discipline yet theory rich discussions orientation structures efforts sustainability science argue niklas luhmann social system theory explains societies communicate problems conceptualize solutions identify pathways towards implementation solutions valuable explaining general structure sustainability science luhmann focus two key concepts first notion resonance offers way account sustainability science attended responded environmental risks product resonance reveal solution oriented research strategic coordination capacities resources information second luhmann interests self organizing processes explain sustainability science simultaneously advance multiple innovations value logic supports multiplicity self organizing activities recognition human natural systems complex coupled mutually influencing give form theoretical framework offer case evidence renewable energy policy formation texas although state wealth rooted fossil fuel heritage texas generates electricity wind state politically antagonistic towards climate change policy yet state reception wind energy technology illustrates social environmental systems strategically aligned generate solutions address diverse needs simultaneously case demonstrates isolating climate change politicians separate discrete problem incapable achieving sustainable solutions resonance offers researchers framework conceptualizing designing
suzaku pattern programming framework enables programmers create pattern based parallel mpi programs without writing mpi message passing code implicit patterns purpose framework simplify message passing programming create better structured programs based upon established parallel design patterns focus developing suzaku teaching parallel programming paper covers main features suzaku describes experiences using parallel programming classes
swimming performance spermatozoa important index success fertilization many years numerous studies reported optimal swimming flagellar organisms nevertheless still question optimal among planar circular helical ellipsoidal helical beating paper use genetic algorithm investigate beat pattern best swimming efficiency based hydrodynamic dissipation internal torque exertion parameters considered results show planar beat optimal small heads helical flagellum optimum larger heads ellipsoidal beat never optimal also genetic optimization reveals wavenumber shape wave envelope relevant parameters whereas wave shape head geometry relatively minor effects efficiency optimal beat respect efficiency based internal torque exertion active elastic flagellum characterized small wave number large amplitude wave lower viscosity medium obtained results optimal waveform consistent observations planar waveforms many respects results suggest necessity detailed flagellar structure fluid interaction address whether real spermatozoa exhibit hydrodynamically efficient swimming evolutional optimization approach used study distinguished biologically important parameters methodology potentially applicable various swimmers elsevier ltd rights reserved
switching cost important factor policy makers consider sets higher price locked consumers making market less competitive though empirical research analyzing switching costs mobile telecommunications market studies considering characteristics smartphones operating systems applications still rare study conduct hypothetical conjoint survey analyze switching cost smartphone handset market derive cost using hierarchical bayesian multinomial logit model consider respondents heterogeneity switching costs handsets empirically estimated magnitudes depend levels searching cost learning cost uncertainty purchasing new smartphones elsevier ltd rights reserved
symmetry breaking problems among well studied field distributed computing yet fundamental questions complexity remain open article work local model input graph underlying distributed network identical study randomized complexity four fundamental symmetry breaking problems graphs computing miss maximal independent sets maximal matchings vertex colorings ruling sets small sample results includes following mis algorithm running log delta root loglogn time delta maximum degree first mis algorithm improve algorithms luby alon babai itai log delta root log comes close omega log delta log log delta lower bound kuhn moscibroda wattenhofer maximal matching algorithm running log delta log log time first significant improvement algorithm israeli itai moreover dependence delta nearly optimal delta coloring algorithm requiring log delta root loglog time improving log delta root logn time algorithm schneider wattenhofer method reducing symmetry breaking problems low arboricity degeneracy graphs low degree graphs roughly speaking arboricity degeneracy graph bounds density subgraph corollaries reduction include root log time maximal matching algorithm graphs arboricity root log log time mis algorithm graphs arboricity log algorithms based simple powerful technique reducing randomized symmetry breaking task corresponding deterministic one poly log size graph
symptoms depersonalization feared social situations commonly experienced individuals social anxiety disorder sad despite clinical relevance addressed standard treatment manuals remains unclear depersonalization reduced well established treatments study investigated whether cognitive therapy sad effectively reduces depersonalization whether pre treatment severity depersonalization predicts mediates treatment outcome randomized controlled trial patients underwent standardized trier social stress test waitlist period compared healthy controls self reported depersonalization measured immediately stress test depersonalization significantly decreased following especially treatment responders eta pre treatment depersonalization neither predict mediate post treatment severity social anxiety prospective studies needed better scientific understanding effect scrutinized whether sad patients suffering depersonalization would benefit specific therapy elsevier ltd rights reserved
synthesis new semiconductors responsive visible light sunlight considered elegant strategy photocatalyst development efficient solar light harvesting applications present study new substituted layered sillen aurivillius oxyhalide intergrowths bilanbox prepared solid state reaction compounds characterized powder ray diffraction xrd field emission scanning electron microscopy sem energy dispersive ray spectroscopy eds vis diffuse reflectance spectroscopy vis drs electrochemical impedance spectroscopy eis photoluminescence studies xrd data revealed formation sillen aurivillius hybrid perovskites isostructural parent compounds binbox sem eds confirmed morphology agglomerates submicron sized particles desired compositions expected band gap pristine oxyhalides lie range indicative sunlight active nature sunlight driven photocatalytic activity studies rhodamine rhb degradation unveiled excellent dye degradation efficiencies bilanbocl bilanbobr acidic medium enhanced photocatalytic activities attributed superior charge carrier separation dye adsorption substituted phases scavenger tests demonstrated active role hole hydroxyl radical key species rhb degradation sunlight presence bilanbobr demonstration enhanced activity natural sunlight significant future development environmental remediation technologies harvesting solar energy
syrian conflict oppression caused extreme suffering syrians threatened existence syrian identity syria territorial integrity caused half syria population internally displaced become refugees goal current study assess physical mental health toll syrian experience intergroup trauma syrians individuals sample internally displaced syrian refugees nederland administered measures oppressive syrian experience soe cumulative stress trauma posttraumatic stress disorder ptsd postcumulative stress trauma disorders complex ptsd existential annihilation anxiety eaa descriptive statistics showed high rates ptsd comorbidities suicidality internally displaced significantly higher morbidity rates refugees using path analysis tested model soe mediated interpersonal traumas triggered eaa affected severely mental physical health model fitted well tested model structural invariance across genders groups model configurally metrically conceptually invariant across groups strongly strictly invariant examined dynamics behind similarities differences discussed need resolve conflict develop evidence based interventions help relieve suffering
system modelling simulation essential engineering especially automatic control systems acs engineering many universities undergraduate curricula include systems control courses dynamic modelling simulations syllabi order design controller physical system one know operational behaviors system well proper controller could designed keeping mind educational computer aided software user friendly visual interface developed software provides opportunity students simulate physical systems without controllers designed since developed accompany undergraduate control system courses main purpose software create interactive practical visual functional environment students taking acs courses therefore called virtual control laboratory vcl basically students able design simulate classical proportional integral derivative pid controllers fuzzy logic controller flc besides type compensator transfer function state space model also combined physical system model simulation analysis laboratory type scope two input channels embedded vcl order visually see analyze simulation results time domain responses students taking acs course also given evaluate proposed educational software students point view wiley periodicals inc
systematic analysis integral aspects within sport enables improvement performance one key aspect management prevention injuries bibliometrics systematic method evaluating research output may expected quantity quality sports injury research time may strongly correlate timing olympic games study conducted determine effect olympic legacy academic sports medicine evidence prevent injuries face teeth literature search within pubmed database undertaken identify quantity literature published annually fields sports injuries injury prevention top journals publishing field identified change impact factor investigated seen since overall increase quantity literature published regarding sports injuries prevention sports injuries respectively publications regarding facial injuries dental injuries within sport show increase respectively increase since almost every journal investigated strong positive correlation seen among journals publishing prevention sports injuries showing median increase statistical significance found olympic years number publications hence gradual increase quality quantity publications regarding sports injuries since however appears immediate added effect olympic legacy following olympic games quantity quality publications fields
systemically acting glucokinase activators gka demonstrated clinical trials effectively lower blood glucose patients type diabetes however mechanism based hypoglycemia major adverse effect limits therapeutic potential agents hypothesized predominant mechanism leading hypoglycemia gka induced excessive insulin secretion pancreatic beta cells sub euglycemic levels hypothesized restricting activation hepatocytes would maintain glucose lowering efficacy significantly reducing hypoglycemic risk report discovery novel series carboxylic acid substituted gkas based pyridine carboxamide gkas exhibit preferential distribution liver versus pancreas mice sar studies led identification potent orally active hepatoselective gka compound gka demonstrated robust glucose lowering efficacy high fat diet fed mice doses mpk fold liver pancreas distribution minimal effects plasma insulin levels significantly reduced risk hypoglycemia published elsevier ltd
acute myeloid leukemia aml characterized translocation chromosomes formation distinctive runx runxt fusion transcript translocation places runxt control runx promoter leading pronounced upregulation runxt transcripts aml compared normal hematopoietic cells investigated role highly upregulated runxt hypothesis acts competing endogenous rna cerna titrating micrornas mirnas away target transcripts thus contributes aml formation using publicly available aml rna seq mirna seq data available cancer genome atlas tcga project obtained network consisting genes may act cernas competing mirnas suggested runxt mirna sponge among cerna candidates previously implied cancer development players integrin cadherin wnt signaling pathways affected runxt sponge overrepresented finally among set high interest runxt cernas found multiple genes previously linked aml formation conclusion study offers novel look role runx runxt fusion transcript aml beyond previously investigated genetic epigenetic aberrations elsevier rights reserved
tafro thrombocytopenia anasarca myelofibrosis renal dysfunction organomegaly syndrome atypical manifestation castleman disease however mechanism underlying rare syndrome remains unknown established standard treatment report cases two young females tafro syndrome showed similar clinical courses cases showed severe anasarca ascites thrombocytopenia although high dose steroids ineffective combination chemotherapy showed remarkable effects however patients developed severe reversible heart failure chop therapy owing diffuse cardiomyopathy presumably associated tafro syndrome therefore although combination chemotherapy may effective treatment tafro syndrome careful observation cardiomyopathy development needed particularly using adriamycin containing regimens
tag popular children playground game revolves around taggers chase tag runners upon roles switch many variations game aim keep children engaged presenting challenges different types gameplay argue introduction sensing floor projection technology playground aid providing variation challenge end need understand players behavior playground steer interactions using projections accordingly paper first analyze behavior taggers runners traditional tag setting focus behavioral cues differ two roles based present probabilistic role recognition model move interactive setting evaluate model tag sessions interactive tag playground model achieves accuracy demonstrates feasibility approach identify several avenues improvement eventually lead thorough understanding happens playground regarding player roles also play breaks example players bored cheat
taizhou changjiang highway bridge longest three pylon two span suspension bridge world investigate seismic performance different connecting configurations deck pylons referred seismic structural systems scale model taizhou changjiang highway bridge incorporating different seismic structural systems tested shake tables tongji university shanghai china paper design construction instrumentation loading protocol test model introduced first fundamental frequencies eight bridge models identified compared numerical results damping ratios corresponding fundamental frequencies obtained half power bandwidth method test results show seismic responses three pylon two span suspension bridge seismic loads highly dependent connecting configurations deck pylons relative displacement responses deck pylons longitudinal direction decreased effectively viscous dampers elastic cables addition influences variations viscous dampers elastic cables response model investigated numerical results test results compared good agreement achieved american society civil engineers
task based language learning tbll heavily influenced syllabus design classroom teaching learner assessment foreign second language teaching context english foreign language efl learning environment paper discussed innovative language learning pedagogy based design education technical writing tbll course language learning based assignments centered designing analyzing objects using various computer aided design software physical lego toolkit design software used collaboratively design analysis done mostly group activities language production activities centered technical document authoring using collaborative online authoring tools website hosting note taking design projects besides oral class presentations online posting english language reception activities readings related course lectures videos assignment assessment instructions hosted linked moodlethe learning management system paper critically analyzed student performance physical lego design cad software including student groups authored websites detailing structural functional specifications related product assembly procedure paper outlined design pedagogy could included curriculum teaching english foreign language process students learnt design fundamentals author complex technical documents english findings based course data class interactions adequately demonstrated students capable handling task based language projects reasonable efficiency confidence
taylor series expansions widely used engineering approximations instance develop finite differences schemes numerical integration methods technical note presents novel technique generate display manipulate taylor series expansion using matrices resulting approach allows algebraic manipulation well differentiation intuitive manner order experiment different numerical schemes truncation errors structures avoiding manual calculation errors detailed explanation mathematical procedure generate matrix form taylor series expansion function two variables presented along algorithm implementation matlab example cases different orders tabulated illustrate generation manipulation capabilities technique additionally extended application developed determine modified equations finite difference schemes partial differential equations one dimensional examples wave equation heat equation using explicit implicit schemes elsevier ltd rights reserved
tea polyphenols find wide range applications food medical pharmaceutical fields owing multi health benefits including antioxidant antibacterial activities cancer prevention antiradiation immune enhancement however low absorption rate tea polyphenols impedes bioactivity vivo low absorption bioavailability attributed poor stability passive diffusion active efflux gastrointestinal tract nanoparticle delivery system based chitosan natural biomaterial widely applied pharmaceutical field enhance absorption bioactive compounds studies reported enhanced absorption bioavailability tea polyphenols application chitosan nanoparticles review describes fabrication methods potential benefits chitosan nanoparticles delivery systems tea polyphenols enhanced absorption tract addition challenges future trends chitosan nanoparticles carrier oral delivery tea polyphenols also discussed elsevier ltd rights reserved
technologies scalable analysis large datasets emerged domain internet computing still rarely used neuroimaging despite existence data research questions need efficient computation tools especially fmri work present software tools application apache spark graphics processing units gpus neuroimaging datasets particular providing distributed file input nifti fmri datasets scala use apache spark environment examples using big data platform graph analysis fmri datasets shown illustrate processing pipelines employing developed tools convenient integration neuroimaging file formats typical processing steps big data technologies could find wider endorsement community leading range potentially useful applications especially view current collaborative creation wealth large data repositories including thousands individual fmri datasets
technology based learning could help students achieve fundamental abilities skills like computational thinking creativity engaging young students computer science concepts programming creative enjoyable way challenging issue aiming apply evaluate constructionist apprenticeship techniques visual programming tools could assist improve learning activity
telecare medicine information systems tmis improve medical healthcare services information communication technology doctor monitor patient physiological condition tmis confidentiality sensitive data protected key issue health insurance portability accountability act guo proposed efficient provably secure certificateless public key encryption scheme tmis claimed scheme secure random oracle model unfortunately giving concrete attack find scheme actually reach security claimed propose improved scheme make defect scheme
temperature based death time estimation based either simple phenomenological models corpse cooling detailed physical heat transfer models latter much complex allow higher accuracy death time estimation principle relevant cooling mechanisms taken account complete workflow finite element based cooling simulation presented following steps demonstrated phantom computer tomography scan segmentation images thermodynamically relevant features individual geometries compilation geometric computer aided design cad model conversion segmentation result finite element simulation model computation model cooling curve mod calculation cooling time cte first time based cooling time estimation steps image segmentation model generation performed semi automatically cooling time calculation results compared cooling measurements performed phantoms controlled conditions context method validated using phantom phantoms thermodynamic material parameters determined via independent experiments moreover impact geometry material parameter uncertainties estimated cooling time investigated sensitivity analysis
teriparatide drug treatment osteoporosis licensed use months little experience retreatment aim study evaluate three patients severe secondary osteoporosis response second cycle teriparatide regarding bone mineral density bmd osteocalcin case year old woman multiple vertebral fractures received corticoids long time starting teriparatide bmd osteocalcin increased received ibandronate years bmd declined second treatment teriparatide bmd increased case year old woman severe osteoporosis lumbar spine score received corticoids long time celiac disease starting teriparatide bmd improved received zoledronic acid months bone density decreased retreated teriparatide bmd slightly higher increase first cycle case year old woman consulted osteoporosis score several fractures hyperthyroidism started teriparatide improvement bmd months received ibandronate year bmd declined retreated teriparatide bmd showed increase indication second cycle treatment teriparatide three patients effective increasing bmd additional studies needed identify benefits safety retreatment teriparatide
test platforms ideal strength materials provided almost defect free nanostructures nanowires nanotubes nanoparticles example work ultimate bending strengths nanowires radii range investigated using new bending protocol nanowires simply held adhesion flat substrates bent sequential atomic force microscopy manipulations bending states prior failure analyzed great detail measure bending dynamics ultimate fracture strength investigated nanowires increase fracture strengths gpa observed radius nanowires decreased large values fracture strength nanowires although comparable ideal strength explained terms surface morphology nanowires
testicular compartment syndrome tcs refers impairment microcirculation testicle due either increased venous resistance extraluminal compression leads hypoxia tcs releases oxidants hypoxia ischemia reperfusion injury iri pathophysiology etiology evaluation management tcs reviewed based properties tcs specific causes varicocele hydrocele orchitis cryptorchidism scrotal hernia suggested categorized oxidant induced stress tcs may explain correlations causes infertility chief shortcoming current imaging modalities detect tcs late progressed impair macrocirculation testicle propose frequent sequential periodic power doppler ultrasonography monitoring earlier detection intraoperatively tcs diagnosed dull purple appearance hypoxic testicle tissue pressures mmhg compartment pressure low underlying etiology must promptly treated acute presentation incision resilient tunica albuginea may necessary great challenge treating tcs restoring microcirculation minimizing iri concomitant antioxidant therapy secondary treatment may effective harmless least testicular oxidant stress common infertility since tcs cause stress tcs may larger factor infertility currently suspected
textbooks state lift drag thrust coefficients numbers must dimensionally proper dimensionless use comparing different data sets paper posits meaningful comparison different data sets numbers must dimensionally physically proper physical propriety satisfied expressing number ratio work energy available aerodynamic system generation lift drag thrust aerodynamic systems addressed paper aircraft propellers lift rotors cylinders magnus effect flapping wings paper introduces normalized lift eta normalized drag eta normalized thrust eta numbers dimensionally physically proper evaluate ability generating lift drag thrust aforementioned systems compare ability different systems numbers shown act like thermal efficiency thermodynamics represent ratio work exerted onto surrounding flowfield kinetic energy available system associated maximum value eta max may exceed read stand alone basis common mathematical format facilitates crosspollination engineering biomechanics biology numerical calculation normalized lift eta blades record breaking quadcopter aerovelo atlas presented compared lift coefficient calculated aerovelo group american society civil engineers
tfe tfeb members mit family hlh leucine zipper transcription factors recent studies demonstrated bind overlapping sets promoters post transcriptionally regulated similar mechanism however tcfeb knockout mice die early embryonic development apparent phenotype reported tfe mice thus raising need characterize physiological role tfe elucidate relationship tfeb tfe deficiency resulted altered mitochondrial morphology function vitro vivo due compromised mitochondrial dynamics addition tfe mice showed significant abnormalities energy balance alterations systemic glucose lipid metabolism resulting enhanced diet induced obesity diabetes conversely viral mediated tfe overexpression improved metabolic abnormalities induced high fat diet hfd tfeb overexpression tfe mice tfe overexpression tcfeb liver specific mice tcfeb liko rescued hfd induced obesity indicating tfeb compensate tfe deficiency vice versa analysis tcfeb liko tfe double mice demonstrated depletion tfe tfeb results additive effects exacerbation hepatic phenotype data indicate tfe tfeb play cooperative rather redundant role control adaptive response whole body metabolism environmental cues diet physical exercise
cells often associated autoimmunity shown increased cdb mice examined role cdb murine collagen induced arthritis cia cbl cdb resistant mice immunized type collagen cdb mice developed arthritis early onset high incidence sustained severity compared cbl mice observed marked leukocyte infiltration histological examinations arthritic paws cdb mice revealed cartilage destroyed association strong lymphocytic infiltration cdb deficiency led enhanced cell differentiation cdb dendritic cells dcs induced much stronger production hence cell differentiation wild type dcs treatment cdb mice establishment treg balance anti receptor mab significantly suppressed induction cells reduced arthritis severity finally severe phenotype arthritis cdb mice rescued adoptive transfer cdb dcs taken together results indicate resistance cia cbl mice regulated cdb via suppression production leading reduced cell differentiation therefore cdb may represent susceptibility factor autoimmunity could target future therapy
cells contribute several inflammatory conditions increasing evidence supports cells glucocorticoid resistant however cells psoriasis related diseases glucocorticoid sensitive compare glucocorticoid sensitive resistant immunological diseases suggest several aspects related diseases alter glucocorticoid sensitivity cells identify molecular pathways implicated glucocorticoid sensitivity cells literature information useful developing approaches overcome glucocorticoid resistant immunopathology
cells associated developing ankylosing spondylitis asthma cells also associated allergic rhinitis atopic dermatitis prevalence allergic diseases patients unknown study intended study risk allergic diseases year follow population newly diagnosed patients used nationwide year population based database retrieved longitudinal health insurance database lhid taiwan study cohort comprised patients least claim inpatient admission least claims ambulatory visit comparison cohort consisted randomly selected subjects matched group ratio used cox proportional hazards regression determine year disease free survival rates adjusting potentially confounding factors patients times greater risk developing asthma within years diagnosis compared non age sex matched subjects adjusting risk factors confidence interval difference significantly different patients also times times greater risk developing allergic rhinitis significantly patients also lower allergic disease free survival rate compared non group results showed patients higher risk developing allergic diseases later life
aac austrian academy corpus diachronic german language digital text corpus million tokens text corpus collected several thousands texts representing wide range different text types primary research aim develop text language resources study texts corpus linguistics corpus based language research large text corpora need structured systematic way structural purpose aac making use notion container container context corpus research understand flexible system pragmatic representation manipulation modification structured storage annotated items text issue representing large corpus formats offer limited space paradigmatic general task representing language small collection text small sample language methods based upon structural normalization standardization developed order provide useful instruments text studies
eight communities chianti area tuscany italy receives average annual rainfall mainly september december nevertheless storage capacity soil sufficient fulfill agricultural requirements resulting shortage water may september almost every year runoff harvesting structures like farm ponds used augment water supplies agricultural areas suitability site farm pond requires careful assessment spatially varying parameters like runoff potential slope land cover therefore spatial analysis continuous runoff potential accounting procedure based soil conservation service curve number scs used evaluate potential water harvesting model evaluation performed based daily runoff events recorded stations statistical indices evaluation model calibration validation respectively mean percent error mean absolute percent error nash sutcliffe coefficient analysis indicated model able estimate observed runoff reasonably well sites suggested model investigated suitability field showed accuracy model given increasing demand water requirements agriculture methodology could effective agricultural areas similar requirements eight communities chianti area elsevier rights reserved
integrated diagnosis infiltrating gliomas revised world health organization classification tumors central nervous system requires assessment tumor idh mutations codeletion since tert promoter mutations atrx alterations shown associated prognosis analyzed whether tumor markers provide additional prognostic information within five categories used data patients ucsf adult glioma study mayo clinic cancer genome atlas tcga infiltrative glioma grades tumor status idh codeletion atrx tert determined cases assigned one groups following diagnostic criteria based morphologic features idh codeletion status groups oligodendroglioma idh mutant codeleted astrocytoma idh mutant glioblastoma idh mutant glioblastoma idh wildtype astrocytoma idh wildtype within group used univariate multivariate cox proportional hazards models assess associations overall survival patient age diagnosis grade atrx alteration status tert promoter mutation status among group idh mutant codeleted oligodendrogliomas tert group significantly worse overall survival tert mut group group idh mutant astrocytomas group idh mutant glioblastomas neither tert mutations atrx alterations significantly associated survival among group idh wildtype glioblastomas atrx alterations associated favorable outcomes among group idh wildtype astrocytomas tert group significantly better overall survival tert mut group thus present evidence certain diagnostic groups testing tert promoter mutations atrx alterations may provide additional useful prognostic information
expansion method expansion method interesting approaches find new general exact solutions nonlinear evolution equations paper methods applied construct new exact travelling wave solutions nonlinear schrodinger equation travelling wave solutions expressed hyperbolic functions trigonometric functions rational functions shown proposed methods provide powerful mathematical tool solving nonlinear wave equations mathematical physics engineering copyright john wiley sons ltd
printing process highlighted nowadays possibility generate individual parts complex geometries moreover development printing hardware software parameters permits manufacture parts used prototypes also made materials suitable implantation way study investigates process involved production patient specific craniofacial implants using calcium phosphate cement dimensional accuracy implants previously generated computer aided design environment based patient tomographic data fabrication implants carried commercial powder printing system using alfa tricalcium phosphate powder aqueous solution nahpo binder fit printed implants measured three dimensional laser scanning checking right adjustment patient anatomical biomodel printed parts presented good degree fitting accuracy
ability capturing unknown attacks attractive feature anomaly based intrusion detection surprising research topic represents one promising directions field network security work consider two different traffic descriptors evaluate ability capturing different kinds anomalies taking account three different measures similarity order discriminate normal network behaviour presence anomalies extensive performance analysis carried publicly available mawilab dataset highlighted proper choice relevant traffic descriptor similarity measure particularly efficient case unknown attacks attacks detected standard misuse based systems
ability derive new insights data using advanced machine learning analytics techniques enhance decision making process companies nevertheless researchers found actual application analytics companies still initial stages therefore paper studies means descriptive survey application analytics regards five different aspects defined delta model data enterprise organization leadership targets techniques applications analysts apply techniques found analytics organization companies matures regards aspects companies started earlier analytics apply nowadays complex techniques neural networks advanced applications analytics predictive analytics moreover analytics differently propagated throughout companies mature larger focus department wide organization wide analytics advanced data governance policy next research means clustering characteristics indicate analytics maturity stage companies discover four clusters clear growth path analytics analytics bootstrappers sustainable analytics adopters disruptive analytics innovators elsevier ltd rights reserved
ability present effectively essential professionals therefore oral communication courses become part curricula higher education studies however speaking public still challenge many graduates tackle problem driven recent advances computer vision techniques prosody analysis multimodal tools designed support development public speaking skills one tools presentation trainer research prototype able provide learners real time feedback set nonverbal communication aspects despite initial positive evaluations application still lacks grounding valid assessment model nonverbal communication aspects context presentations come model conducted semi structured interviews experts public speaking domain furthermore objective interviews also formative evaluation presentation trainer analysing suits common practices teaching learning public speaking skills results study identify nonverbal communication practices affect quality presentation summarize experts points view regarding multimodal public speaker instructors
abstraction computer graphics defines procedure discriminates essential information worth keeping usually details correspond higher frequency components allow distinguish otherwise similar images vice versa low frequencies related main information larger structures contours may also identified high frequencies separate pictured component underlying idea proposed algorithm consists identifying edges redundant wavelet transform blurring inner areas components adaptive circular median filter spite implementation simplicity unsupervised methodology provides results similar obtained complex techniques already described literature elsevier inc rights reserved
accuracy reliability anomaly based network intrusion detection system dependent quality data used build normal behavior profile however obtaining datasets trivial due privacy obsolescence suitability issues paper presents approach traffic trace sanitization based identification anomalous patterns three dimensional entropy space flow traffic data captured campus network anomaly free datasets generated filtering attacks traffic pieces modify typical position centroids entropy space analyses performed real life traffic traces show sanitized datasets homogeneity consistency terms cluster centroids probability distributions pca transformed entropy space
active medium pulsed doil volume generation iodine atoms experimentally simulated using chemical generator singlet oxygen discharge understand feasibility pulsed oxygen iodine laser electrical generator singlet oxygen
activity lateral habenula lhb represents substrate encoding negative valenced events exposure aversive stimuli naive mice sufficient trigger reduction gaba mediated signaling lhb ultimately instrumental hyperactivity lhb neurons establishment depressive like phenotypes however mechanisms responsible induction aversion driven plasticity missing using vivo patch clamp recordings slices show exposing mice series inescapable footshocks fse rapidly reduces baclofen mediated gaba currents lhb plasticity gaba signaling requires activation dopamine stress pathways indeed systemic administration dopamine glucocorticoids receptor antagonists prevents fse induced reduction gaba currents lhb test whether recruitment receptors occurs within lhb exposed slices control mice either dopamine corticosterone manipulations failed alter amplitudes baclofen mediated gaba currents altogether data suggest dopamine stress signaling necessary induction fse evoked gaba plasticity lhb however activation specific receptors may occur structures different lhb suggesting circuit based mechanism form plasticity findings provide mechanistic insights aversion driven plasticity within lhb
advancement micro nanotechnologies continuously providing possibilities inventing novel biochemical sensors however variations transducer type cause different sensing results due differences mechanisms analyzing biomolecular interactions work focused comparative analysis static non static assays molecular interactions using chip integrated extended gate field effect transistor egfet static sensing interface solidly mounted resonator smr non static sensing interface analysis polyelectrolytes pets surface assembly antigen antibody interaction using two types biochemical sensors presented consistent complementary sets information meanwhile due difference operating mechanisms variations detection efficiency kinetics thermodynamics observed results highlighted critical dependence signal detection biochemical sensors operating mechanisms provided valuable guidance static non static assays biomolecular detections elsevier rights reserved
advent linked data spurring deployment applications use rdf data model information tier addition querying rdf data also requirement online updates suitable concurrency control client sessions web applications organized transactions involving requests read write shared data executing concurrently sessions may invalidate data paper presents locking model variant multigranularity locking protocol mgl address isolation transactions manipulate rdf data four hierarchically related granules defined well new read write operations corresponding lock modes specifically created rdf data model new operations allow greater concurrency classical read write operations relational databases assessed performance proposed locking model model simulation elsevier rights reserved
adverse effects obesity female reproduction extensively documented however prospective studies examined preconception weight loss interventions need develop successful interventions significant weight loss compliance importantly document effects preconception interventions important perinatal outcomes live birth health infant mother existing data randomized trials come closest meeting criteria failed document improved live birth rates intervention compared control groups tendency equate favorable weight change pregnancy direct qualitative improvement perinatal outcomes yet results successful treatment morbid obesity bariatric surgery average weight loss suggest mixed risk benefit ratio perinatal outcomes although interventions control gestational weight gain completely studied preconception ones documented successful interventions achieve appropriate weight gain clear evidence controlling gestational weight gain actually improves important perinatal outcome future studies must develop successful effective interventions capture perinatal outcomes instead weight change primary outcomes use least preconception new antiobesity drugs combination therapies study bariatric surgery prospective trials improve understanding effectiveness obesity treatment pregnancy american society reproductive medicine
ageing population increasing wish living independently motivating development welfare healthcare models existing approaches based direct heath monitoring using body sensor networks bsn precise accurate nonetheless intrusiveness causes non acceptance new approaches seek indirect monitoring monitoring activities daily living adls proves suitable solution adl monitoring systems use many heterogeneous sensors less intrusive less expensive bsn however deployment maintenance wireless sensor networks wsn prevent widespread acceptance work novel technique monitor human activity based non intrusive load monitoring nilm presented proposal uses smart meter data leads minimum intrusiveness potential massive deployment minimal cost could key develop sustainable healthcare models smart homes capable complying elderly people demands study also uses dempster shafer theory provide daily score normality regard regular behavior approach evaluated using real datasets additionally benchmarking gaussian mixture model approach presented
aim physiological modeling control study model understand biological processes apply identification control strategies system big challenge combine individualized control therapies physiological model based robust control methods requires combination mathematical knowledge numeric symbolic computations control engineering system identification control theory computer engineering formal methods software development testing biomedical engineering physiological modeling paper discusses current challenges topic three concrete examples diabetes tumor control depth anesthesia
aim paper demonstrate regenerative otto cycle adiabatic polytropic expansion achieve improved performance traditional otto engines even exceeding carnot factor thus work deals novel regenerative otto based internal combustion engine differs conventional otto thermal cycles process heat conversion mechanical work performed obeying polytropic path function instead conventional adiabatic expansion without regeneration design characteristics concern fact combustion constant volume carried undergoing large air excess top combustion temperature significantly lower conventional otto cycles consequently nox emissions neglected furthermore polytropic expansion based path function heat absorbed submitted controlled heat flow rate achieve desired polytropic expansion analysis regenerative otto based polytropic expansion presented results compared regenerative otto based adiabatic expansion results show relevant advantage proposed regenerative otto polytropic expansion regenerative otto cycle adiabatic expansion involves performance enhancement within wide range combustion pressures temperatures regeneration capacities thus thermal efficiency specific work function top combustion pressure ranges respectively combustion pressures vary kpa kpa lower thermal efficiency successful results involving compact engine structure technically economically viable promises new generation efficient reciprocating internal combustion engines operating relatively low temperatures crown copyright published elsevier ltd rights reserved
aim paper present design procedure optimal controller minimizing type norm discrete time stochastic linear systems periodic coefficients simultaneously affected nonhomogeneous periodic markov chain state control multiplicative white noise perturbations firstly two type norms linear stochastic systems consideration introduced type norms may viewed measures effect additive white noise perturbations regulated output considered system deriving state space representation optimal controller useful formulae two type norms obtained formulae expressed terms periodic solutions suitable linear equations derived absence additional assumptions regarding markov chain periodicity sequence transition probability matrices shown optimal controller depends stabilizing solutions specific systems coupled riccati equations generalize well known control filtering equations linear time invariant case readers convenience paper presents iterative numerical algorithms computations stabilizing solutions riccati type systems theoretical developments illustrated numerical examples copyright john wiley sons ltd
aim present study extend expansion method fractional differential difference equations rational type particular time fractional models considered show strength method three types exact solutions observed hyperbolic trigonometric rational exact solutions terms topological solitons singular periodic functions also obtained far aware results published elsewhere previously
aim present study investigate lineaments kolli hills tamil nadu state cartosat satellite dem output made use extracted lineaments analysed using arcgis rockworks software total number length lineaments respectively shorter lineaments constitute total number lineaments density lineaments varies areas high high density restricted south central central north eastern parts areas reflect high degree rock fracturing shearing makes areas unsuitable construction dams reservoirs however areas could targeted groundwater exploitation possess higher groundwater potential lineaments oriented diverse directions however orienting enewsw predominating followed oriented sub sub directions orientations corroborate results previous regional studies orientations prominent geological structures features study area distinct variation predominant orientations lineaments varied sizes observed shorter ones oriented either nnw sse directions longer ones oriented either ene wsw comparative analysis lineament datasets eight azimuth angles final lineament map underlines need extract lineaments various azimuth angles get reliable picture lineaments
aim present study investigate role myristicin myr allyl methoxy methy lenedioxybenzene active aromatic compound isolated nutmeg carrot basil cinnamon parsley hypoxia induced apoptosis rat dorsal root ganglion drg neurons observed myr significantly enhanced cell viability hypoxia induced drg neurons dose dependent manner optimal concentration myr furthermore myr reduced percentage deoxynucleotidyl transferase mediated dutp nick end labeling positive neuronal cells influenced expression pro apoptotic gene cell lymphoma bcl associated protein apoptosis protease cleaved caspase anti apoptotic gene bcl hypoxia induced group addition myr protected hypoxic injury drg neurons inhibiting malondialdehyde lactate dehydrogenase however upregulating superoxide dismutase glutathione peroxidase myr reduced expression endoplasmic reticulum stress ers markers including ccaat enhancer binding protein homologous protein glucose related protein cleaved caspase hypoxia induced group best knowledge first demonstration activity myr hypoxia induced apoptosis rat drg neurons via inhibition ers pathway
aim study analyze etiology incidence sports injuries among wheelchair rugby players moreover verified levels aggressiveness anger presented athletes roles team influenced incidence severity injuries study involved male players members polish national wheelchair rugby team month period athletes participated training camps wheelchair rugby tournaments study based competitive aggressiveness anger scale registry sports injuries consulted non consulted physician demographic questionnaire following observations made month period corresponding mean training tournament days wheelchair rugby players experienced primarily minor injuries require medical intervention four injuries needed consulted physician sports injuries occurred frequently among offensive players defensive players offensive players showed tendency higher levels anger aggressiveness defensive players concluded wheelchair rugby discipline associated high incidence minor injuries require medical intervention incidence rate injuries analyzed period per athlete per training day
aim study describe use emergency contraception family health units recife march september questionnaire answered professionals nurses physicians selected random sampling usf almost professionals reported availability family health unit physicians nurse main prescribers knew distribution strategy women health kit although professionals already prescribed considered woman right majority understand family planning manual ministry health half understand reproductive rights manual municipality manual knew action mechanism usually inform women among explain main reasons lack opportunity physicians avoid becoming routine nurses half professionals reported prescribing three recommended situations unprotected intercourse rape failure contraceptive methodin use agree religion interfere decision prescription advice health professionals demonstrated sufficient technical knowledge prescribe recognize right women also consider influence religion may interfere decision prescribing use women
aim study determine frequency followership styles connection job satisfaction satisfaction extrinsic intrinsic aspects work teachers sample included secondary school teachers three grammar three vocational schools three towns serbia results indicate prominent followership styles star followers pragmatists star followers attached greater significance intrinsic aspects work reported higher job satisfaction rate pragmatists placed importance extrinsic ones independent thinking correlated intrinsic aspects work job satisfaction active participation job satisfaction work aspects results also show higher degree engagement particularly combined economic satisfaction predicted higher level job satisfaction dominant followership motivational structures teachers learnt management educational institutions would improved teachers participate making work decisions greater sense empowerment commitment organizational goals although affected types personality dominant followership structures teacher may influenced course professional training thereby directing towards development functional followership types
aim study identify analyze perceived benefits associated sports injury professional semi professional players injured sports practice data collection semi structured interviews conducted content analyses performed qsr nvivo software participants reported perceived benefits throughout injury process social support sports education referrals findings point importance including positive aspects clearer complete understanding overall impact sports injuries
aim study investigate reasons adult learners took longer required complete master doctoral degrees questionnaire focus group interviews used collect data twenty adult learners registered master doctoral degrees one township campus university targeted responded participants lived townships obtained primary secondary tertiary education township schools found lack computer skills poor research skills inadequate access internet stress supervision problems well employer workload contributed enormously adult learners inability complete studies within prescribed period study also highlighted impact apartheid education adult learners postgraduate level apartheid education system characterised poor education provision played major role slow completion masters doctoral degrees african adult learners recommended african adult learners enroll masters doctoral degrees training research approaches computer skills information search stress management prior study study duration masters doctoral degrees also need reviewed especially adult learners students obtained education township schools
aim study test feasibility using commercially available computer aided design computer aided manufacturing cad cam technology including shape dental system trial version wieland wieland zenotec milling machine design fabricate complete dentures modeling process full denture available trial version shape dental system used design virtual complete dentures basis dimensional digital edentulous models generated physical models virtual complete dentures designed exported cam software wieland wieland zenotec milling machine controlled cam software used fabricate physical dentitions baseplates milling acrylic resin composite plates physical dentitions bonded corresponding baseplates form maxillary mandibular complete dentures virtual complete dentures successfully designed using software several steps including generation digital edentulous models model analysis arrangement artificial teeth trimming relief area occlusal adjustment physical dentitions baseplates successfully fabricated according designed virtual complete dentures using milling machine controlled cam software bonding physical dentitions corresponding baseplates generated final physical complete dentures study demonstrated complete dentures could successfully designed fabricated using cad cam
aim article provide insight phenomenon sexual harassment theatre world survey among norwegian actors presented showing sexual harassment much prevalent theatre world norwegian work life general article aims understanding prevalence high based qualitative interviews article points risk factors shed light high prevalence sexual harassment lastly risk factors related charismatic authority important power base theatre world
aim paper present development implementation tracking algorithm horizon radar othr surface wave propagation proposed implementation utilizes standard tracking algorithm design othr introduces modifications joint probability data association jpda algorithm order simplify processing justify chosen approach simulated environment consisting one othr corresponding targets created proposed implementation tested
aim paper present overcurrent limitation digital peak current mode converter proposed method detect overcurrent real time also maintains arbitrary current overcurrent limitation mode expected provide effective function protect renewable energy system effectiveness proposed method confirmed simulated experimental results
aim paper propose neural network based reference modified pid control simple duration design method transient characteristics improvement digitally controlled converters renewable energy network systems various types converters widely used power conversion converters require superior control method stable operation especially transient characteristics improved since heavily affect stability system purposes designing conventional control methods becomes difficult task since optimization control parameters needs complicated analysis affected variations circuit components converters therefore simple easy design control widely required stable operation power converters neural network provide suitable control methodology situation since treats plant black box realize non linear control based training input output relation without complicated modelling analysis hand neural network based method disadvantage caused fact neural network trained data obtained advance overcompensation phenomenon occurs transient response paper neural network control adopted control converter coordination conventional pid control neural network predicts output voltage converter reference value pid control modified predictions reduce error output voltage avoid overcompensation simple duration design neural network control also provided improve transient response effectively prototype testing simulation experiment revealed proposed method contributes obtain superior transient performance compared conventional pid control
aim paper show results various experimental tests carried synchronous reluctance rel motors different rotor geometries proposed technical literature impact assistance ferrite permanent magnet inset flux barriers considered assisted rel motors compared synchronous rel motors highlighting main benefits former solution effect rotor skewing adopting asymmetric geometries flux barriers reduce torque ripple investigated means several tests impact lamination also considered far overload capability concerned addition experimental tests finite element model adopted predict performance motors predicted results compared experimental ones wide operating range showing good agreement
aim paper contribute elaboration environmental stress hypothesis framework testing eight hypotheses addressing direct impact gross motor coordination problems elementary school selected physical behavioral psychosocial outcomes adolescence results based longitudinal sample participants recruited part population based representative survey health physical fitness physical activity childhood adolescence assessed twice within years ages years old well ages years old response rate iii classified gross motor coordination problems gross motor coordination problems baseline motor tests korperkoordinationstest measures weight height validated physical activity questionnaire well strength difficulties questionnaire conducted data analyzed use binary logistic regressions results indicated elementary school children gross motor coordination problems show higher risk persistent gross motor coordination problems avoiding organized physical activities elevated body mass bonding sedentary peers well emotional conduct problems adolescence comparison elementary school children without gross motor coordination problems however elementary school children gross motor coordination problems show significantly higher risk peer problems diminished prosocial behavior adolescence respectively comparison elementary school children without gross motor coordination problems study first provide population based longitudinal data ranging childhood adolescence context environmental stress hypothesis considered substantial methodological progress summary gross motor coordination problems represent serious issue healthy transition childhood adolescence substantiates respective early movement interventions
aim present study conduct literature review studies address topic football visually impaired studies originally published portuguese english analyzed reference databases pubmed sportdiscus web science scopus beyond scielo electronic library google scholar research utilized keywords futebol futebol cinco futebol soccer football side deficiente visual deficiencia visual visually impaired person visually impaired persons blind persons blind person paralympic isolate together main studies football address historical context presentations sport scientific community addition studies concern analyzing tactical aspects sport well sport injuries football practice five studies seeking address aspects organization training periodization specific physiology demands technical aspects learning initiation training modality
aim research investigate causes emergence sports injuries explain differences psychological response regard severity injury examined competing slovene athletes surgically treated knee injury estimated time rehabilitation severely injured athletes six months sustained less severe injuries faced month long rehabilitation measured athletes personality traits athletic identity coping pain rehabilitation beliefs motivation social support provided family coach well colleagues results showed group severely injured athletes demonstrated behaviour less inhibited response group athletes less severe injuries psychological response proved almost groups except higher levels catastrophizing higher individual coping response found group severely injured athletes furthermore masculinity found predict self efficacy individual coping response strength athletic identity predicted motivation rehabilitation value emotional lability predicted catastrophizing self efficacy athletes lower athletic identity lower masculinity higher emotional lability exposed adjustment difficulties sustaining athletic injury opinion strategies successful rehabilitation sports injury aimed identification athletes personality traits pose higher risk experiencing adjustment difficulties promoting adequate motivation increasing coach support application cognitive behavioural strategies
aim research work based design development motorized yam pounder pounding yam research considered importance pounded yam africa particularly nigeria time energy wasted using traditional mortar pestle method yam pounding research work aimed eliminating labour involved traditional method pounding improvement possibility food contamination sweating pounding control project work sought design yam pounder pounds yam right peeled cooked stage pounding bowl help electric motor transmits power rotary motion together help shaft pounding blades functions pestle machine operated electricity consists shaft electric motor yam beaters pounding blades bowl frame low cost materials used make machine affordable average nigerian homes thereby improving standard living order avoid food contamination stainless material also incorporated smooth clean pounding consumption
aim review article examine solutions challenges associated adhesively bonded fibre reinforced polymer frp pipe sections frp materials used piping systems years higher specific mechanical properties corrosion resistance frp makes potential candidate replacing metallic piping structures another advantage frp structures large number design variables available despite advantages associated frp structures application still limited partly due unsatisfactory methods joining composite subcomponents inadequate knowledge failure mechanisms different loading conditions adhesively bonded joints attractive many applications since offer integrated sealing minimal part count require pipe extremities complex geometries threads bell spigot configurations normally adhesive joint results uniform stress distribution undamaged fibre architecture smooth surface contours present article comprehensive review various joining techniques frp piping adhesive bonding presented damage mechanisms different loading conditions examined elsevier ltd rights reserved
aim study analyze relationships maladaptive use internet mobile phone various imbalances social skills stress management self esteem life satisfaction explore differences uses abuses according socio demographic variables gender age using two stage sampling convenience intra group randomized downsampling selected students boys girls aged years enrolled several secondary schools principado asturias spain according results found imbalances stress management skills predict likely misuse technologies also difficulties managing stress lack communication skills predict problematic uses internet related compulsive habits self control problems conflicts generated feelings confirmed girls older adolescents suffer problems related mobile phone use problematic implications problematic uses discussed abounds desirability promoting prevention psychosocial intervention sociedad universitaria investigacion psicologia salud published elsevier espana open access article license http creativecommons org licenses
aim study describe differences ontogenesis omasum sheep domestic ruminant deer wild ruminant total embryos fetuses merino sheep iberian deer used first stages prenatal life birth study animals divided five experimental groups according relevant histological characteristics appearance omasum primitive gastric tube earlier sheep gestation days deer gestation days cases displayed primitive epithelium stratified cylindrical non ciliary type appearance four laminae different sizes always earlier sheep deer around gestation sheep days days deer omasum consisted clearly differentiated layers mucosa epithelial layer lamina propria submucosa tunica muscularis serosa temporal order appearance four order laminae omasal papillae always earlier sheep deer tegumentary mucosa omasum without secretion capability first embryonic phases days gestation neutral mucopoly saccharides appeared deer days gestation sheep cases continued decrease birth decrease pronounced deer finally presence neuroendocrine glial cells detected deer earlier stages sheep
aim study evaluate effects vilazodone sexual functioning healthy sexually active adults assess impact medication nonadherence type trial participants randomized vilazodone day paroxetine day placebo weeks double blind treatment primary endpoint change baseline day change sexual functioning questionnaire csfq total score intent treat itt population post hoc analyses carried modified intent treat mitt populations excluded participants active treatment groups undetectable plasma drug concentrations visits mitt least one visit mitt itt population statistically significant differences treatment groups csfq total score change placebo vilazodone day vilazodone day paroxetine mitt mitt csfq total score change significantly different vilazodone either dose versus placebo csfq total score decreased significantly paroxetine versus placebo vilazodone day versus vilazodone day vilazodone exerted significant effect sexual functioning healthy adults medication nonadherence alter study results may important consideration trials volunteer participants copyright wolters kluwer health inc rights reserved
aim study investigating protective effect mulberry digest mbd acrylamideinduced oxidative stress composition analysis mbd revealed contained six major phenolic compounds quercetin nitinoside quercetin hexoside quercetin rhamnosylhexoside hexoside kaempferol rhamnosylhexoside cyanidin glucoside cyanidin rutinoside vitro digestion contents two anthocyanins decreased significantly contents four flavonoid glycosides increased addition mbd found successfully suppress acrylamide induced ros overproduction restore mitochondrial membrane potential inhibit mitochondrial membrane lipid peroxidation glutathione depletion interestingly protective effect mbd acrylamide induced oxidative damage enhanced compared mulberry fruits without digestion mbe study revealed mbd enhanced cell resistance capacity acrylamideinduced oxidative stress rather direct reaction acrylamide overall results indicate mbd provides potent protection acrylamide induced oxidative stress elsevier ltd rights reserved
aim study assess diagnostic value psoriatic arthritis screening evaluation pase early psoriatic arthritis screening questionnaire earp questionnaires ultrasonographic detection enthesitis synovitis tenosynovitis cross sectional study done total consecutive patients double blind clinical examination echographic assessment performed receiver operating characteristic roc model analysis questionnaires established using echographic findings reference variable optimal diagnostic point determined following youden analysis model obtained data calculating sensitivity specificity along predictive values likelihood ratio diagnostic odds ratio logistic regression analysis used determine possible predictor variables enthesitis synovitis tenosynovitis enthesitis synovitis tenosynovitis considered one outcome diagnostic study pase earp questionnaire statistically significant differences among score study groups rest patients pase earp tests diagnostic performance enthesitis synovitis tenosynovitis followed expected pattern prevalence findings low cases tests increase negative predictive value particularly interesting ruling disease
aim study assess role addenbrooke cognitive examination test ace evaluation cognitive status migraineurs interictally total adolescent patients healthy controls matched age gender undergone ace testing migraineurs additionally questioned migraine aura features presence higher cortical dysfunctions hcd aura according questionnaire results patients subsequently divided hcd non hcd group ace scores migraine patients significantly lower healthy controls also subscores memory verbal fluency significantly higher control population correlation hcd occurrence cognitive examination score although non hcd subgroup achieved better score findings shown migraineurs get lower ace test scores tendency poorer outcome complex aura also study revealed ace test easily administered test brief assessment cognitive status migraineurs future perspectives could evaluation ace test larger sample size impact migraine aura cognitive function adolescents
aim study assess validity reliability turkish version fatigue severity scale fss parkinson disease patients use clinical settings consecutive patients included study turkish version fss analyzed reliability internal consistency reproducibility validity convergent discriminant turkish version fss yielded acceptable internal consistency cronbach alpha corrected item total correlations established reproducible test retest intraclass correlations items fss total score correlated significantly related variables group differences items total score fss modified hoehn yahr staging found statistically significant present study shown turkish version fss valid reliable tool assessment fatigue patients copyright wolters kluwer health inc rights reserved
aim study design multiepitope universal vaccine major human papillomavirus hpv structural proteins bioinformatics models purpose predicted probable immunogenic epitopes common high risk hpv beside high prevalent type based bcpreds defaulted model solvent accessibility structure extrapolated three dimensional molecular model protein constructed swiss model server whereas sequence alignment provided model prediction protein epitopes glycosylation sites excluded estimated epitope regions bioinformatics analyses epitopes selected fused tandem repeats reverse translated codon optimized relevant sequence final protein parameters antigenicity analyzed protean program evaluation new recombinant protein sequence indicated molecular weight kda amino acids beside positive charge computed isoelectric point value indicated acidic nature final product aliphatic index showed low thermal stability construct grand average hydropathicity value negative analyzed plot showed major parts new protein construct hydrophilic property thus harboring antigenic potency sequence final construct reverse translated dna codon optimized sequence showed codon adaptation index cai expression escherichia coli finally sequence ligated peta bacterial expression vector new recombinant proteins harboring cell epitope seem suitable antigens based computational methods universal vaccine candidate hpvs
aim study develop korean version stigma scale chronic illness items ssci assess reliability construct validity among patients neurological conditions patients diagnosed stroke parkinson disease epilepsy multiple sclerosis myasthenia gravis amyotrophic lateral sclerosis recruited reliability assessed internal consistency cronbach alpha coefficient exploratory factor analysis efa used extract potential factors korean ssci convergent validity assessed correlating scores korean ssci scores depression using beck depression inventory anxiety using spielberger state trait anxiety inventory functional ability using korean modified barthel index mbi respectively total patients enrolled study recruited stroke parkinson disease epilepsy korean ssci high internal consistency cronbach alpha korean ssci retrieved one factor eight items efa factor loading scores korean ssci correlated positively depression anxiety negatively mbi study shows korean ssci unidimensional model even though includes items enacted internalized stigma reliable valid assessing stigma among korean patients neurological disease
aim study develop automated fuzzy controller microcontroller consisting hardware software control supervision thermal environment broiler farms study conducted two steps first one performed computer analysis simulation second step performed evaluation software hardware developed equipment test registration thermal environment variables within facility activation climate control equipment experiment conducted poultry house broilers cobb lineage aged days experimental farm located bambui presented prototype able operate automatic way equipment control ambience poultry farms supervision meteorological variables developed fuzzy controller estimated satisfactorily thermal comfort poultry days experiment keeping thermal parameters within specified literature system used automation ambience equipment four steps production chain broiler chickens
aim study evaluate accuracy novel software cmf precads prediction soft tissue changes following repositioning surgery zygomatic fractures twenty patients sustained isolated zygomatic fracture accompanied facial deformity treated repositioning surgery participated study cone beam computed tomography cbct scans three dimensional stereophotographs acquired preoperatively postoperatively skeletal model preoperative cbct data matched postoperative one fractured zygomatic fragments segmented aligned postoperative position prediction predicted model matched postoperative stereophotograph quantification simulation error mean absolute error zygomatic soft tissue region predicted model real one cases accuracy prediction mean absolute error subjective assessment found majority evaluators considered predicted model postoperative model similar cmf precads software provide realistic accurate prediction facial soft tissue appearance repositioning surgery zygomatic fractures reliability software types repositioning surgery maxillofacial fractures validated future
aim study evaluate thymus function mice hypertension total cbl mice randomized control sham surgery two kidney one clip groups weeks surgery mice sacrificed blood spleens kidneys thymuses harvested results reverse transcription quantitative polymerase chain reaction analysis revealed mrna levels forkhead box protein foxn autoimmune regulator aire thymus tissue mice htn group significantly lower control group weeks foxn aire expression also reduced sham surgery group weeks surgery recovered weeks later similar results observed expression signal joint cell receptor excision circles percentages cell subsets present study indicates impaired thymus function associated hypertension mice suggests thymus function may novel target treatment patients hypertension
aim study examine upper respiratory tract infections urti associations resting saliva blood immune endocrine parameters ice hockey players twenty seven participants age years completed week study period counts concentrations immune endocrine markers compared healthy prone athletes episodes urti urti state athletes infections healthy state time without urti differences concentration counts saliva blood immune endocrine parameters illness prone illness free athletes athletes significantly lower siga siga siga concentrations siga siga siga respectively significantly higher wbc neutrophil monocyte eosinophil count values concentration time symptoms urti period without symptoms infections differences salivary cortisol concentration period urti symptoms period without urti symptoms conclusion observed lower concentrations salivary immunoglobulins higher levels blood immune parameters urti athletes may confirm suppression mucosal immunity initiation responses pathogenic infections innate immunity
aim study explore japanese young adults use social networking sites sns social psychological factors might impact sns security settings survey employed examine usage habits actual account settings risk perception social cognition related twitter results indicate discrepancies among privacy concerns usage habits actual privacy settings twitter users respondents actually use public settings accounts half disclose personal details profile despite believing private information disclosed twitter respondents also exhibited optimistic cognition behavior regarding online privacy risks negative stereotypes toward twitter users whose accounts protected possibility social cognitive factors impact user privacy settings discussed paper
aim study explore feasibility luscher color test lct psychological instrument based theory colors selected unconscious way color sensory perception color objective universal research involved ethiopian women delivered getche health center gurage seemed relevant majority ethiopian women identify rejected color gray favorite color yellow yellow color suggests better express personality physical context gray color indicates want live experience intensely exploratory work lays foundations studies disadvantaged women developing low income countries well industrialized countries characterized high level emigration clinical applications complete lct version
aim study explore significant predictors associated electroconvulsive therapy ect outcome patients major depressive disorder major depressive disorder inpatients requiring ect recruited major psychiatric center south taiwan ect generally performed maximum sessions symptom severity assessed using item hamilton depression rating scale hamd clinical global impression severity cgi ect every three ect sessions last ect generalized estimating equations method used analyze influence potential variables time hamd cgi respectively fourteen patients completing first three sessions ect excluded remaining patients included analysis patients treatment resistant depression longer duration current depressive episode higher levels pain likely less symptom reduction acute treatment ect irrespective depressive symptoms rated using hamd cgi improve efficacy earlier application ect pain control considered acute course ect clinical predictors related ect outcome require investigation future studies
aim study investigate childhood fears children blind perspective teachers blind study conducted jordan forty six teachers interviewed results revealed main fear content children blind includes fear unknown environment transportation people related fear fear animals teachers reported reasons fear children visual impairment include child related reasons internal reasons lack training hearing social skills orientation mobility tactile training family factors unsuitable physical environment training independence training family counselling environment adaptation reported best procedures deal fear children recommendations provided light study
aim study investigate effect methyl jasmonate salicylic acid quality parameters apricot fruit treatments cold storage degrees days shelf life days degrees day cold storage treatment fruit quality parameters included physico chemical characteristics weight loss fruit firmness total soluble solids acidity total soluble solids acidity ratio juice sensory properties skin flesh colour texture taste visual appearance overall acceptability among physico chemical characteristics applications mmol methyl jasmonate mmol salicylic acid significantly reduced fruit weight loss fruit softening juice maintained soluble solid content acidity whole storage period among sensory properties parameters generally increased methyl jasmonate salicylic acid treatments compared water treated control water treated fruits showed lowest scores acceptability limit except skin colour conclusion results suggest using methyl jasmonate salicylic acid enhance prolong storability apricot fruits cold storage shelf life period
aim study investigate factorial structure psychometric properties separation anxiety assessment scale saas spanish schoolchildren participants study children aged exploratory factor analysis identified four factors worry calamitous events fear abandonment fear alone fear physical illness explained variance participants study schoolchildren aged four related factors model validated confirmatory factor analysis internal consistency alpha temporal stability good convergent validity evident pattern correlations measures separation anxiety sensitivity anxiety school fears sensitivity scale specificity complementary subscales predicted diagnosis separation anxiety disorder results support reliability validity clinical utility saas
aim study investigate relationship single nucleotide polymorphisms snps interleukin alpha receptor ilra gene rheumatoid arthritis chinese population examined patients subjects control group three snps genotyped using taqman genotyping assays fluidigm system allele increased patient group compared control subjects significant difference genotype distribution found patients controls chi also discovered statistical significance dominant model versus however significant difference discovered recessive model versus interestingly significant differences detected allele genotype frequencies anti ccp positive patients anti ccp negative patients chi chi respectively also found significant difference genotype frequency females compared males chi unfortunately failed find significant results two snps susceptibility findings suggest polymorphism might contribute susceptibility
aim study translate western ontario meniscal evaluation tool womet dutch evaluate content validity construct validity reliability responsiveness determine minimal important change mic dutch version womet translated dutch according standardized forward backward translation protocol atotal patients males females median age years interquartile range years isolated meniscal pathology included womet completed three times baseline around weeks months baseline knee injury osteoarthritis outcome score international knee documentation committee subjective knee form short form anchor question also answered good results content validity floor ceiling effects construct validity predefined hypotheses confirmed internal consistency cronbach alpha subscale score test retest reliability intraclass correlation coefficient total womet score responsiveness predefined hypotheses confirmed smallest detectable change mic dutch womet respectively dutch version womet valid reliable assessing health related quality life patients meniscal pathology
aim study use structured assessments assess dental students clinical communication skills exhibited patient appointments fourth year dental students university alabama birmingham evaluated interpersonal skills clinical setting utilizing four habits coding scheme instructor also assessed student patient clinical communication assessments used identify perceived strengths weaknesses students clinical communication instructor assessments student self assessments pinpointed following clinical communication skills effective often patient greeting avoidance jargon non verbal behavior also relative agreement instructor assessments student self assessments regarding clinical communication skills rated effective frequently ensuring patient comprehension identification patient feelings exploration barriers treatment resulted pointed strengths weaknesses portion curriculum designed prepare students effective provider patient communication results may suggest need school current behavioral science curriculum better address discussion potential treatment barriers patient feelings well techniques ensure patient comprehension
aim work synthesis type fuzzy logic pid controller boost converters performances proposed controller evaluated compared type fuzzy logic pid controller using structure similar operating conditions simulation results showed type fuzzy logic pid controller better performances type fuzzy logic pid controller
aims present paper explore traditional gender roles focusing mainly attitudes towards division labour men women relate social cohesion examine whether relationship differs among men women multi dimensional concept social cohesion measured two general components behavioural dimension consisting civic political participation intensity non kin social relations attitudinal dimension institutional trust solidarity analysis based data european values study luxembourg reveals traditional related higher attitudinal cohesion higher institutional trust solidarity conversely traditional attitudes associated less cohesive behaviour namely lower intensity non kin social relations political participation tradition oriented women show significantly lower levels political participation male counterparts whereas traditional men tend demonstrate less solidarity women
aims study apply integrative cardiopulmonary ultrasound thoracic ultrasound evaluation patients interstitial lung disease ild determine relationship lung ultrasound signs echocardiographic parameters systolic pulmonary artery pressure spap various right ventricular parameters ild patients healthy controls underwent lung ultrasound lus echocardiographic tests addition traditional echocardiographic parameters right ventricular free wall longitudinal strain rvls measured using speckle tracking echocardiography degree pulmonary fibrosis disease severity ild patient scored semiquantitative scoring method taking account multiple lus signs statistical analyses performed compare various parameters ild patients without pulmonary hypertension correlations different parameters evaluated lus scores used predict pulmonary hypertension using receiver operating characteristic curve analysis among patients qualified entry study pulmonary hypertension patients pulmonary hypertension larger right ventricular dimensions lower rvls higher lus scores effective correlation found ild lus scores echocardiographic parameters especially spap thoracic ultrasound useful assessment ild ild progresses structure function right ventricle gradually deteriorates lus detects lung conditions ild also indirectly reflects spap right ventricular function integrated use lus echocardiography provide invaluable point care imaging modality facilitate diagnosis management treatment patients ild world federation ultrasound medicine biology
optical linear array reconfigurable pipelined bus system olarpbs optical conduit parallel computing model consists pipelined optical conduits buses interconnect optical processing elements previous work olarpbs following designs predecessor models considered interconnections mostly rigidly connected linear array processing elements specific order rigidness results communication memory bound architecture imposes algorithm scheduling difficulties potentially limit capability model highly scalable flexible interconnect designed high bandwidth high speed interconnections developed paper matrix multiplication algorithm designed take advantage new interconnection design includes comparison previous algorithm advantages include addressing communication limitations enabling flexible algorithms increased processing efficiency
ambient assisted living aal area constant evolution providing new technologies users enhancing level security comfort ensured house platforms ambient assisted living aalall project aims develop new aal concept supported unified ecosystem certification process enables heterogeneous environment concepts intelligent environments ambient intelligence foundations ambient assisted living presented framework project work consider specific platform developed scope aalall called useraccess architecture platform role within overall aalall concept implementation platform available interfaces presented addition feasibility validated series tests
american manufacturing workforce currently well trained undertake increased modern day usage robotics workplace past robots computers primarily used aid routine dangerous tasks skill level necessary operators systems specialized nature different manufacturers differing coding operating schemes robotic systems employed generally inflexible changes product product demand even working queue products family past decade major push field robotic design integrated robotic systems work tandem human operators making flexible also imbuing innate ability produce multiple products small lots time manner added ability allows robots past worked independently communicate robots flexible robotic cells human supervisors sharing information cycle time work progress problems associated undertaking routine manufacturing firms continue adopt operational improvement strategies like lean agile manufacturing focus shift integration robots manufacturing system current manufacturing engineering education programs nationwide need aware impending change embark upon introducing concepts curriculum paper sets forth framework systems engineering robotics coexist current pedagogical environments framework based modification manufacturing engineering program indiana state university utilizing interview session one north america largest producer oriented polypropylene films framework established seeks find common ground manufacturing engineering programs nationwide
ammonothermal crystal growth technique one effective methods used growing gallium nitride gan crystals terms final product quality manufacturing efficiency popular applications gan crystals include light emitting diodes leds high frequency electronic devices laterally heated cylindrical enclosure top bottom temperature gradient considered study investigate fluid mechanics heat transfer ammonothermal crystal growth reactor three dimensional large eddy simulations les results natural convection laterally heated cylindrical reactor using commercial computational fluid dynamics cfd software ansys fluent presented paper rayleigh number defined based length scale equal ratio volume lateral area cylinder addition experiment geometrically dynamically similar geometry developed particle image velocimetry piv based flow visualizations carried purpose validating numerical model comparisons experiments numerical simulations showed flow patterns qualitatively similar fourier transforms velocity magnitudes selected points domain matched reasonably well added interesting observation simulation existence temperature inversion potential implications choice mineralizer acidic basic elsevier masson sas rights reserved
amount postnatal experience perinatal rats manipulated delivering pups one day early post conception day cesarean delivery comparing motor behavior age matched controls typical day birth pups tested multiple measures motor coordination leg extension response ler facial wiping contact righting fore hindlimb stepping ler facial wiping provided measures synchronous hind forelimb coordination respectively sensory evoked contact righting also sensory evoked provided measure axial coordination stepping provided measure alternated forelimb hindlimb coordination induced serotonin receptor agonist quipazine pups delivered prematurely spent additional day postnatal environment showed bilateral limb coordination expression ler facial wiping well mature righting strategy compared controls findings suggest experience around time birth shapes motor coordination expression species typical behavior developing rat published elsevier inc
amygdala plays key role emotional learning processing emotions disturbed amygdala function linked several psychiatric conditions knowledge biochemistry especially neurotransmitter levels highly desirable spin echo full intensity acquired localized special sequence together transmit receive coil used perform short magnetic resonance spectroscopy determine neurochemical profile spectroscopic voxel containing amygdala healthy adult subjects spectral analysis advanced data processing applied combination macromolecule baseline measured anterior cingulate spectral fitting concentrations total acetylaspartate total creatine total choline myo inositol first time glutamate quantified high reliability uncertainties far metabolites inter individual variability reflected relative standard deviations cohort studied varied glutamate myo inositol glutamine glutathione could also determined albeit lower precision retest four subjects showed good reproducibility devised method allows determination metabolite concentrations amygdala voxel including glutamate provides estimation glutamine glutathione may help study disturbed amygdala metabolism pathologies anxiety disorder autism major depression
analog circuit design often focused design frequency filters employing different types active elements paper present universal voltage conveyor used design khn equivalent filters working voltage mode auxiliary voltage inputs active elements used reduce number floating admittances structure proposed structures easily cascadable since input output impedances theory infinitely high zero respectively behavior filters verified pspice simulations furthermore experimental measurements elsevier gmbh rights reserved
analysis mimo multiport antennas requires measurement efficiency well parameters total efficiency seen port includes impedance mismatch input reflection coefficient must considered multiport context input reflection coefficient loaded port network derived mason rule signal flow graph however larger method becomes complicated approach presented paper matrix method gives insightful general expression input reflection coefficient result consistent known results mason rule makeup resulting formulation shows input reflection coefficient impacted various scattering parameters multiport antenna load reflection coefficients ports
analysis pottery settlement uttumer escher part dfg project studies riverside find complexes roman iron age lower weser lower ems rivers order identify possible function wharves piers pottery uttumer escher stands unusually high proportion organically tempered ceramic ware reflecting pottery variant already known contemporary settlements astride ems typological comparisons pottery analyses conducted closer examination chronologically restricted regional pottery tradition confirmed already assumed peculiar manufacturing engineering also frequent evidence pottery dutch settlement area although different dating critical review basis dating individual sites countries reveals could well contemporary phenomenon rendered possible necessity add special temper limey clay
analysis retina blood vessels clinics indices one efficient methods employed diagnosing diseases diabetes hypertension arthrosclerosis paper efficient algorithm proposed introduces higher ability segmentation employing skeletonization threshold selection based fuzzy entropy first step blurring noises caused hand shakings ophthalmoscopy color photography imageries removed designed wieners filter second step basic extraction blood vessels retina based adaptive filtering obtained last step proposed method optimal threshold discriminating main vessels retina parts tissue achieved employing fuzzy entropy finally assessment procedure based four different measurement techniques terms retinal fundus colors established applied drive stare database images due evaluation comparative results proposed extraction retina blood vessels enables specialists determine progression stage potential diseases accurate real time mode elsevier rights reserved
anonymity bitcoin prevents analysis users collect google trends data examine determinants interest bitcoin based anecdotal evidence regarding bitcoin users construct proxies four possible clientele computer programming enthusiasts speculative investors libertarians criminals computer programming illegal activity search terms positively correlated bitcoin interest libertarian investment terms
antigenic reactivity constituents schistosoma mansoni peanut arachis hypogaea investigated determine whether identical antigenic epitopes possessed organisms provided possible explanation negative correlation chronic schistosome infection atopy allergens aqueous extracts peanuts probed western immunoblots rabbit igg antibodies raised egg cercarial adult worm stages mansoni several molecules peanut extract antigenically reactive antibodies various rabbit anti schistosome sera pair cross reactive peanut molecules similar molecular weight purified proteins identified mass spectrometric analysis peanut allergen ara anti mansoni soluble egg antigen antibodies eluted peanut molecules reacted two mansoni egg antigens identified mass spectrometry ipse alignments amino acid sequences ara either ipse revealed low level peptide sequence identity incubation nitrocellulose paper carrying electrophoresed peanut molecules six constituents allergic plants mansoni egg antigens mild solution sodium metaperiodate probing antibodies inhibited cross reactivities results consistent antigenic cross reactive epitopes mansoni egg antigens peanut allergic plants cross reactive carbohydrate determinants ccds findings novel explanation based blocking antibodies could provide insight inverse relationship observed schistosome infection allergies
anti stealth radar seeker difficult problem present nir defense missile area studying depth using anti stealth technology ground radar reference originally present anti stealth technology netted live radar seekers borne double missiles ais feasible pragmatic anti stealth technology radar seeker near future
application equilibrium thermodynamics study thermal plant performance real operating conditions constant challenge paper analysis reservoir pressure piston working two linear flow resistances performed considering friction piston cylinder system walls proposed model developed obtain optimum power output speed piston terms first law efficiency friction piston cylinder assembly neglected expressions obtained consistent presented literature laminar regime also demonstrated laminar turbulent regimes overall size constraints power delivered maximized balancing upstream downstream flow resistances piston paper also evaluated influence overall size constraints flow regime performance piston cylinder analysis equivalent evaluate irreversibilities endo irreversible carnot heat engine heat loss resistance engine heat reservoirs proposed model introduced modifications results obtained recent literature led important conclusions finally proposed model applied calculate lost available work turbine operating steady flow conditions ideal gas working fluid
application system identification techniques modeling flexible beam structure presented paper flexible beam widely applied various fields engineering industrial however flexible structure easily influenced unwanted vibration may lead fatigue performance reduction structure damage thus unwanted vibration must controlled reduced order good controller performance vibration suppression appropriate model flexible beam required hence obtain model flexible beam structure particle swarm optimization pso artificial bee colony abc implemented study system identification techniques implementation pso abc requires experimental data input output retrieved data acquisition well developed experimental test rig via matlab simulink platform results obtained displayed graphical plots numerical values predicted model validated via mean square error mse correlation tests represent dynamic model flexible beam structure model minimum mse value correlation test within confidence interval selected best fit model result shows pso algorithm produces better performance compared abc algorithm order predicted model lowest mse value correlation tests within confidence interval beam system
application terrestrial laser scanners tlss construction sites automating construction progress monitoring controlling structural dimension compliance growing markedly however current research construction management relies planned building information model bim assign accumulated point clouds corresponding structural elements may reliable cases dimensions built structure differ planned model planned model available sufficient detail addition outliers exist construction site datasets due data artefacts caused moving objects occlusions dust order overcome aforementioned limitations novel method robust classification segmentation planar linear features proposed reduce effects outliers present lidar data collected construction sites first coplanar collinear points classified robust principal components analysis procedure classified points grouped using robust clustering method method also proposed robustly extract points belonging flat slab floors ceilings without performing aforementioned stages order preserve computational efficiency applicability proposed method investigated two scenarios namely laboratory million points actual construction site million points results obtained two experiments validate suitability proposed method robust segmentation planar linear features contaminated datasets collected construction sites
archival constructive views memory offer contrasting characterizations remembering relation memory errors evaluate descriptive adequacy offering close analysis one prominent experimental techniques memory errors elicited deese roediger mcdermott drm paradigm deese roediger mcdermott explaining drm effect requires appreciating distinct form memory error refer misremembering misremembering memory error relies successful retention targeted event differs successful remembering confabulation errors representation produced wholly inaccurate show neither archival constructive view account drm effect insensitive misremembering unique explanatory demands fortunately explanatory limitations archival constructive views complementary suggests way forward explaining misremembering including differs successful remembering confabulation requires hybrid theory memory combining archival commitment discrete retention constructive approach retrieval conclude paper beginning sketches account
areas ambient assisted living aal intelligent systems full development still issues resolved one issue myriad user oriented solutions rarely built interact integrate systems available market paper present aalall project useraccess implementation showing novel approach towards virtual organizations interoperability certification aim project provide collaborative network services devices connect every user product developers building heterogeneous ecosystem thus establishing environment collaborative care systems may available users safety services comfort services healthcare services
arthritis self efficacy scale ases valid tool measure patients arthritis specific self efficacy however evidence reliability validity ases chinese arthritis patients lacking study aimed culturally adapt test psychometric properties chinese version ases chinese ases translated original english version using translation back translation procedures validation survey conducted university affiliated hospital set questionnaires comprised chinese ases pain vas hospital anxiety depression scale hads functional assessment chronic illness therapy fatigue facit short form item health survey physical functioning subscale convenience sample patients rheumatoid arthritis recruited department rheumatology validity assessed pearson correlation analysis exploratory factor analysis reliability assessed using intra class correlation coefficient icc cronbach alpha exploratory factor analysis extracted one dimension explained variation significant negative correlations found ases pain vas hads hads scores positive correlations found ases facit excellent test retest reliability icc internal consistency cronbach alpha demonstrated chinese version ases statistically acceptable levels reliability validity assessing self efficacy patients rheumatoid arthritis disease specific scale particularly valuable use among patients rheumatoid arthritis chinese population
article aims highlight conceptual apparatus contemporary science problem solving techniques also type raised issues testify shift paradigm namely passage cosmos paradigm chaos paradigm significance old paradigm especially considering astonishing longevity related explanatory potential also innate strife humans dwell aesthetically ethically attractive unconditionally intelligible world reductionist methodology became established framework mechanistic worldview case simplicity seen main measure intelligibility however important detail elasticity words vagueness simplicity concept insufficiently considered shift towards new paradigm chaos presented well grounded effort liberation universe anthropocentrism apriority
article analyses party documents rhetoric kotleba people party slovakia lsns demonstrates culturally conservative instrumental paternalist populist attitude gender issues thematic analysis indicates lsns seeks promote traditional gender roles exclusion women public space also uses quasi feminist arguments instance call women engage public life support patriarchal agenda findings show gender related issues feature peripherally lsns rhetoric however used strategically theme cuts across party ideology forming core purposely used relation party main priorities lsns uses gender related themes part political arsenal increasing party support amongst women seeking involve women party activities increase acceptability among voters
article analyses operation reciprocal internal combustion engines marine engines used example analysis takes account types energy conversion work spaces cylinders engines loads crankshaft piston assemblies types fuel combustion take place spaces engine operation highlighted analysed time dependent loads marine internal combustion engine crankshaft piston assemblies random processes also indicated wear elements assemblies resulting load also considered random process hypothesis formulated explains random nature load absence theoretically expected detonation combustion engines supplied fuels diesel oil marine diesel oil heavy fuel oil model proposed fuel combustion arbitrary work space marine diesel engine form stochastic four state process discrete states continuous time model based theory semi markov processes
article deals semantic data model application data integration analyses issue mapping database schemes particularly relational models common data models expressed form ontology substantial part dedicated methods acquiring ontology relational databases rules creating classes properties hierarchies cardinalities instances specified
article deals place electronic kits didactic system science technical subjects briefly summarizes measurements support computer kit laboratory measurement demonstration wiring electrical circuits within general didactics electro technical kits among didactic material resources term didactic tool range wide rich content default term issue educational resources important didactic categories
article describes distributed parameter model acoustic field fluid enclosed within bounded domain model given form abstract partial differential equations defined appropriate function space theory partial differential equations well certain results linear functional analysis used formulation description state space representation problem formulated analyzed means techniques
article describes approach assessing maturity risk management manufacturing organization designing developing product risk management process maturity guarantees successful product design development terms cost schedule quality paper proposes risk management maturity model based six levels capability capability maturity model integration cmmi four dimensions organizations namely culture risk management process experience business applications model evaluates organization four dimensions cmmi capability levels determines stands terms capability cmmi ordinal scale end case study presented domain assembly auto differentials evaluate risk management maturity assembly line
article describes created measurement setup equipped user interface allowing parallel measurement transient phenomena electrical circuits harmonic analysis nonharmonic signals electrical circuits detailed explanation created user interface created programming environment matlab advantages usage given
article describes obstacles emancipation roma women family czech society theoretical side deals recent changes gender roles roma family changes position roma women discrimination well concept emancipation article aims describe obstacles roma woman must overcome course emancipation data based qualitative socio ethnographic research conducted narrative interviews women different ages classes identify roma live three czech regional capitals research sample compiled using snowball method data collected field research analyzed atlas using anchored theory identified five main obstacles emancipation roma woman include obstacles emanating family majority society well obstacles caused hegemony masculinity emanating woman gaining understanding relations roma families situation regarding emancipation roma women associated barriers may help come daily contact roma minority take appropriate actions apply right interventions
article discusses drug abuse eating disorders critical gender healthcare perspectives postulating subjective suffering expressed body psychosomatic illnesses perspective craving drugs superfluous consumer goods illness self imposed hunger pursuit ideal slimness anorexia bulimia symptoms expose woman suffering review fields public health feminist theories highlights magnitude phenomena medicalization commodification health psy chiatrization female discomfort gender transition capitalist societies social demands performance old new women roles accentuate feelings inadequacy expressed gender discomfort permeating drug abuse eating disorders analyzed diseases protest study proposes reclaim ideals program comprehensive women healthcare deal challenges
article presents generalization group mutual exclusion gme problem called group local mutual exclusion glme henceforth glme activities neighboring nodes need synchronized however synchronization required non neighbors neighborhood defined based location shared resources token based solution glme problem also proposed solution satisfies correctness criteria group mutual exclusion safety starvation freedom concurrent occupancy illustration includes simulation extensive results estimate message overhead latency concurrency session switch complexity simulation results prove proposed algorithm demonstrates better performance compared closest work literature token loss problem also handled best knowledge algorithm presented paper first token based algorithm solve glme problem manets
article presents circuits electrical signals belonging impulses space periodic signals space real distribution electrical currents occurs meet principle minimum energy losses paper presents solution problem using control system form current dependent voltage sources entering meshes set complex rlc network shown control energy neutral
article presents results examining wind turbine vertical axis rotation study conducted open circuit wind tunnel gunt laboratory department thermodynamics fluid mechanics aviation propulsion systems lublin university technology subject research rotor based patent blades capable altering surface active area receiving kinetic energy wind study performed appropriately scaled geometrically similar models maintaining relevant type research criterion numbers studied rotors different blade inclination angles produced using powder printer zprinter results conducted research obtained flow velocity three inclination angles degrees degrees degrees variable rotational speed test equipment used study allows maintaining required speed recording velocity torque turn allows engineer measure characteristics torque power function rotor speed
article proposes optimal secondary controller combined load frequency control lfc automatic voltage regulation avr multi source multi area system using simulated annealing technique subjected load disturbance frequency tie line power voltage fluctuations results higher oscillations speed governor system helps match generation demand fine tuning frequency tie line power voltage subjected load disturbance multi source multi area system achieved secondary proportional integral derivative pid controller conventional benchmark pid controller tuned using zeigler nichol method optimized using simulated annealing technique performance system validated judged using performance indices elsevier ltd rights reserved
article provides theoretical basis multi agent recursive cognitive architectures distributed intelligent system decision making control ambient intelligence system dealt formalization cognitive architectures based recursive deterministic abstract automata work introduces method automatic contexts formation systems ambient security based formal representation semantics attempts made model visualize semantic primitives contexts successful experiments multi agent representation subset natural language limited domain ambient assisted living systems elderly people conducted
article suggests evaluation method offset voltage bijfet differential difference operational amplifiers ddas based theory autonomous multiport circuit static error dda connected offset voltage presented current autonomous parameter connected highimpedance node entered classical equivalent circuit parameter determined dda circuitry ideally must zero value conditions synthesis main functional nodes dda obtained whereby approximate provided range low temperatures radiation effect example construction bijfet dda small drift given
asphalt pavement heated solar attracted great attentions heating urban cities called urban heat island uhi fact solar energy heating asphalt pavements also potential ability bring geological disasters permafrost qinghai tibet plateau qtp study designed special solar heating reflective coating layer shrcl order cool asphalt pavement surface cooling performance shrcls studied comparing temperatures normal pavements shrcls result indicated shrcl could work expected resulting reducing around degrees compared normal pavement matter top bottom temperature difference top bottom degrees shrcls also normal pavements less linking coating coating field testing result agrees well laboratory study enhance skid resistance shrcls sands added coatings without influencing cooling performance reducing abrasive resistance accelerated pavement testing apt employed evaluate engineering performance shrcl suggested inhomogeneous deformation rutting bring cracking spalling asphalt pavement surfaces coating layers elsevier ltd rights reserved
assessment investment efficiency plays critical role investment prioritization context electrical network expansion planning hence paper proposes new criteria cost efficiency investment applied investment ranking process electrical network planning based assessment new investment candidates impact active power losses bus voltages line loadings network three general criteria chosen due strong economic influence active power losses line loadings considered due significant impact quality supply allowed voltage profile electrical network reliability supply addressed since criterion already extensively applied solutions regarding investment efficiency assessment proposed ranking procedure involves stochastic approach applying monte carlo method scenario preparation number scenarios reduced means procedure order speed investment efficiency assessment proposed ranking procedure tested using standard new england test system results show based newly involved investment assessment criteria indices system operators obtain prioritized list investments prevent excessive economically wasteful spending elsevier ltd rights reserved
assessment grid electrification programs developing countries largely based mini grid solar home system shs shown faced low development imparts sustainability challenges resulted failure many projects study provides solutions surmount challenges leaning experience hybrid solar diesel mini grid tsumkwe village namibia provides analyses case study based empirical evidence field studies interviews representatives households public institutions energy providers addition investigates technical challenges economic impacts electrification program homer matlab models used analysis investigations findings show despite challenges system sustained keyed existing structure growth potentials progressive tariff system adopted government helped cushion costs allow low income households energy matrix adoption strict maintenance measures implementation energy efficiency measures prior commissioning program resulted reduction costs success elements identified study could extrapolated sub saharan african countries challenges properly addressed elsevier ltd rights reserved
assumption mood affects investors behavior field gaining acceptance due experimental studies papers linking stock returns environmental variables weather length day identify mood effects paper utilizes account level stock trading data investors finland country significant variation weather length day weather related mood variables calendar effects individually significant little day day variation trading collectively explained factors contrast find strong seasonal lower frequency patterns seem connected vacations elsevier rights reserved
auditory steady state response assr increasingly used biomarker neuropsychiatric disorders research investigating test retest reliability measure needed previously reported assr reliability measured electroencephalography eeg amplitude modulated white noise click train stimuli purpose current study assess reliability meg measured assr amplitude modulated white noise click train stimuli compare test retest reliability meg eeg measures assr previously investigated additionally impact stimulus parameter choice reliability assessed comparing responses white noise click train stimuli test retest reliability across sessions approximately one week apart assessed healthy adults study day participants completed two passive listening tasks white noise click train stimuli separate meg eeg recordings session correlations evoked power inter trial phase coherence itpc assessed following source space projection overall meg measured assr significantly correlated sessions fdr corrected suggesting acceptable test retest reliability results suggest greater response reproducibility itpc compared evoked responses click train compared white noise stimuli although study warranted significant differences reliability observed meg eeg measures suggesting similarly reliable work supports use assr biomarker clinical interventions repeated measures elsevier rights reserved
auditory system exhibits differences sex sexual orientation implication relevant auditory structures altered prenatal development possibly exposure androgens otoacoustic emissions oaes newborn male infants weaker newborn females sex differences persist lifespan oaes nonheterosexual females also weaker heterosexual females suggesting atypically strong exposure androgens time early development auditory evoked potentials aeps also exhibit sex differences beginning early life aeps different heterosexual nonheterosexual females aeps different heterosexual nonheterosexual males research non humans treated androgenic anti androgenic agents also suggests oaes masculinized prenatal exposure androgens late gestation collectively evidence suggests prenatal androgens acting globally locally affect nonheterosexuality auditory system elsevier inc rights reserved
author analyzes process formation development research field cybernetics became flourishing era computer technology highest achievements scientific field cybernetics ussr siberian physical technical institute sphti tomsk state university tsu became center formation development research field cybernetics east ussr early department radiophysics tsu associate professors tarasenko medvedev senior research associates zakrevsky tarasenko organized group young teachers students tsu sphti decided start implementation major government topic developing applied issues information theory development electronic computers later year first computer siberia ural set sphti marked beginning scientific school field informatics tomsk polytechnic institute tpi implemented research field automation particle accelerators mathematical modeling use computer technology automation optimization systems organizational management university short time intense pace research field cybernetics turned tomsk research education complex research center national scale research field cybernetics important theoretical practical significance studies developed large schools thought conducted research promising areas cybernetics employees sphti zakrevsky developed logical representation language synthesis algorithms discrete automata lyapas sophisticated systems well number automatic synthesis digital machines design research organizations ussr basis lyapas computer programming system generation created anticipated numerous ideas developed abroad generation machines electron synchrotron sirius designed launched tpi employees powerful country one largest world basic research physics acceleration charged particles nuclear physics elementary particle physics solid state physics conducted sitius
author elaborates problems influence quality engineering existing construction technology operation requirements quality control aspects procedure construction process eps external thermal insulation system puts forward corresponding control measures construction technologies puts forward measures construction management aspects materials quality inspection combination control construction technologies management construction qualities eps external thermal insulation system meet requirements functions aspect construction
authors examined joint interactive roles second step curriculum validated social emotional learning bullying prevention program committee children seattle parenting practices students behavioral academic outcomes grades participants parents children schools control treatment level random coefficient model conducted assess effect parental monitoring school outcomes well interaction character development curriculum parental monitoring results indicated parental monitoring significant predictor school behaviors school grades furthermore second step curriculum moderated relationship parental monitoring problem behaviors prosocial behaviors grades school specifically schools without second step curriculum parental monitoring predicted higher school grades impact students school behaviors contrast schools second step curriculum parental monitoring predicted fewer problem behaviors well prosocial behaviors study results highlight joint influences family school children behavioral academic trajectories results implications education intervention including improving school climate student behaviors learning achievement
authors examined role sympathy moral respect children overt aggression subtypes proactive reactive aggression ethnically diverse sample year olds aggressive behaviors measured teacher reports peer nominations sympathy assessed teacher reports children reported moral respect within interview procedure asked feelings respect toward hypothetical peers displayed morally relevant behaviors results revealed sympathy moral respect negatively related overt aggression proactive aggression subtype unrelated reactive aggression subtype authors discuss implications findings relation developmental research affective antecedents children aggressive behavior
authors previously shown many traditional approaches operational modal analysis oma struggle properly identify modal damping ratios bridges traffic loading due interference caused driving frequencies traffic loads paper presents novel methodology modal parameter estimation oma overcomes problems presented driving frequencies significantly improves damping estimates methodology based finding power spectral density psd given modal coordinate dividing modal psd separate regions left right side spectra modal coordinates found using blind source separation bss algorithm curve fitting technique developed uses optimization find modal parameters best fit side spectra psd specifically pattern search optimization method combined clustering analysis algorithm together employed series stages order improve estimates modal damping ratios method used estimate damping ratios simulated bridge model subjected moving traffic loads results method compared established oma methods frequency domain decomposition fdd bss methods found accurate reliable even modes psds distorted altered driving frequencies elsevier ltd rights reserved
authors investigated associations young adults perceived purposes emerging adulthood attitudes toward participation cohabitation sample never married individuals ages female white united states young people perceptions period life associated acceptance cohabitation reasoning accepting cohabitation likelihood cohabiting results showed perception emerging adulthood time prepare future family roles negatively associated acceptance cohabitation whereas perception emerging adulthood time take risks positively associated acceptance cohabitation perception emerging adulthood time prepare future family roles associated increased likelihood cohabited perception emerging adulthood time possibilities associated decreased likelihood cohabited implications future research discussed
authors study explored body pattern measurement shape relationships trouser patterns drafted two methods consistency body pattern relationships methods differently shaped bodies within methods patternmaking procedures cause outcomes findings impact garment fit particularly mass customization body pattern measurement shape relationships inconsistent within methods making unsuitable use computer aided custom patternmaking strikingly pattern crotch shapes similar within method despite fact form crotch shapes different patternmaking procedures causing inconsistencies include use proportion noncorresponding body measurements use standard rather body measurements variations ease proportions standard amounts trueing blending connecting steps variation methods measurements used use proportions standard measurements steps disregard body shape
authors present method predicting long term deformation materials based base diagram concept long term strength calculation steels different specified stress temperature values showed efficiency defining relations advantage approach common parametric methods larson miller orr sherby dorn manson sakkop trunin parameters shown
authors present protocol security architecture smart grid advanced metering infrastructure ami various levels hierarchical grid isolated protocol planes preventing propagation attacks utility meters interconnected via wireless technologies order metering functions well location identification reporting attackers amended version bell labs security framework aka itu protects every component added first response security apparatus forensic component location determination algorithm fortifying phy wlan interconnecting meters
authors report growth beta gao nanowires using vapor phase transport method photoelectrochemical photocathode hydrogen generation splitting water light illumination observed variations photocurrent bias voltage depend strongly morphology crystal quality beta gao nanowires electrolyte three electrode photoelectrochemical pec efficiencies gao nanowires zero bias voltage samples grown degrees respectively essential requirement resistance reactions electrochemical corrosion photocorrosion dissolution solid liquid interface demonstrated results suggest gao nanowires applied designing high performance pec devices
automatic design synchronous reluctance syr machines considered paper means finite element analysis multiobjective optimization algorithms mooas research focuses design rotor geometry key aspect syr machine design particular performance three popular mooas analyzed compared terms quality final design computational time procedure minimize computational burden optimized design process introduced applied three layer five layer rotor two prototypes experimentally demonstrate feasibility design procedure
automotive industry facing tremendous growth engineering software intensive systems giving rise various challenges prevent problems related fit new software technologies vehicles manufacturing processes well functioning interaction functions product development manufacturing crucial complicated fact changeable nature software development causes unprecedented needs collaboration coordination two functions paper reports process assessment focuses interface functions product development manufacturing development design software intensive automotive systems main purpose study identify key issues improvement area assessed assessment performed two swedish automotive companies data collected documents interviews practitioners nine key improvement issues established ranging challenges requirements engineering need knowledge transfer manufacturing product development addition increase understandability results map possible avenues solution future research paper provides extensive analysis improvement issue relation state art
availability medical imaging data clinical archives research literature clinical manuals coupled recent advances computer vision offer opportunity image based diagnosis teaching biomedical research however content semantics image vary depending modality identification image modality important preliminary step key challenge automatically classifying modality medical image due visual characteristics different modalities visually distinct others may subtle differences challenge compounded variations appearance images based diseases depicted lack sufficient training data modalities paper introduce new method classifying medical images uses ensemble different convolutional neural network cnn architectures cnns state art image classification technique learns optimal image features given classification task hypothesise different cnn architectures learn different levels semantic image representation thus ensemble cnns enable higher quality features extracted method develops new feature extractor fine tuning cnns initialized large dataset natural images fine tuning process leverages generic image features natural images fundamental images optimizes variety medical imaging modalities features used train numerous multiclass classifiers whose posterior probabilities fused predict modalities unseen images experiments imageclef medical image public dataset modalities training images test images show ensemble fine tuned cnns achieves higher accuracy established cnns ensemble also achieves higher accuracy methods literature evaluated benchmark dataset overtaken methods source additional training data
availability high resolution vhr optical sensors growing image archive frequently updated allows use change detection post disaster recovery monitoring robust rapid results proposed semi automated gis object based method uses readily available pre disaster gis data adds existing knowledge processing enhance change detection also allows targeting specific types changes pertaining similar man made objects change detection method based pre post normalized index gradient intensity texture edge similarity filters within object set training data change quantified based training data method used automatically detect change order observe recovery time large areas analysis time also contribute obtaining full picture recovery development disaster thereby giving managers better understanding productive management practices elsevier rights reserved
avoidance allergens allergen specific immunotherapy ait curative treatments allergic diseases requires identification offending allergens based clinical history results allergy tests also prior attempts stabilize disease drugs ait polysensitized patients severe allergic diseases difficult control major challenge report case year old girl rhinitis severe asthma attributed mites dermatophagoides pteronyssinus dennatophagoides farinae grass pollen cat dander addition omaluzimab pre established optimal treatment helped control disease allowed initiate sublingual immunotherapy slit slit well tolerated omaluzimab administration also drug discontinued treatment led complete control allergic disease symptoms respiratory function immunoassays several studies shown omalizumab increases tolerance efficacy ait patients respiratory hymenoptera venom allergies however studies omalizumab treatment maintained ait results young polysensitized girl severe asthma agree results reported studies showed pretreatment omalizumab could lead better tolerance efficacy ait moreover also reported ait act synergistically omalizumab involves induction mechanisms immune regulation elsevier masson sas rights reserved
background proposed vibration isolation method based principle active pressure control minimizing cyclic load transmitted system base elastic pneumatic element paper presents research effectiveness pid control algorithm back calculation integrator part pressure pulsation inside pneumatic element vibration isolator studied frequency range includes sub resonant resonant frequencies spectral analysis conducted order analyze harmonic excitation response active pneumatic isolation system passive one disabled valves control minimal bore size response rate control valve defined achieve least double advantage active system passive one frequency range including vibration isolator resonant frequency expected proposed control algorithm demonstrated decent decrease pressure pulsation amplitude low frequency range hertz level excitation signal calculation data analysis shows pid control algorithm back calculation integrator part effectively used active pneumatic vibration isolator control valve parameters within specified ranges authors published elsevier ltd
balance excitatory inhibitory neurotransmitters brain affects neural responses behaviour humans animals investigated whether dietary intervention aimed increasing levels inhibitory neurotransmitter gamma aminobutyric acid gaba influence neural responses basic sensory stimuli using steady state electroencephalography eeg paradigm found neural response visual patterns reduced individuals consumed yeast extract product rich substances associated production gaba glutamate vitamins control group consumed placebo substance per group demonstrates balance excitation inhibition brain influenced dietary interventions suggesting possible clinical benefits conditions epilepsy inhibition abnormal
benefits effective leadership practices often examined however little known practices impact perceptions agency employees regarding whistle blowing instance two cross sectional studies found examine association transformational leadership often studied leadership practice whistle blowing attitudes extend studies examined relationship transformational oriented leadership behaviours whistle blowing attitudes using panel data findings revealed transformational oriented leadership increased extent employees agencies felt could disclose wrongdoing without facing retaliation transactional oriented leadership also found positive effect whistle blowing behaviours however effect size smaller implications findings thoroughly discussed article
benefits progressive resistance training prt among older adults evident especially prevention sarcopenia improving muscle strength reverse age related loss functional ability however prt carries risk particularly participants older adults certain degree muscle weakness purpose article discuss prt related injuries present overview documented shoulder injuries among elderly discerning possible mechanisms injury risk factors literature search conducted pubmed database identify relevant literature using combinations keywords strength training injuries resistance training injuries sports injuries elderly shoulder complex shoulder injury shoulder disorder acute chronic injuries attributed prt cited epidemiological literature shoulder complex alluded one prevalent regions injury particularly exercises place arm extended head posterior trunk however risk injuries appears higher testing training one repetition maximum strength testing may result greater injury risk technique though acceptable needs additional precautions inexperience older adults prevent injury thus best treatment prt age related injuries prevention appropriate individualized training programs use safe equipment careful warming cooling correct range motion progressive intensity training cardiovascular musculoskeletal fitness essential aspects injury prevention among elderly
biological resistance different preservatives mechanical properties particleboard key role panel performance attack ability microcerotermes diversus anacanthotermes vagans termites particleboard evaluated also mechanical properties particleboards measured alkaline copper quat acq boron fluorine chromium arsenic bfca salts chlorotalonil ctl used particleboard protection termite degradation grading termite attack performed accordance astm specifications research conducted sistan region months field condition weight loss grading values indicated particleboard degradation exposed anacanthotermes vagans termite biological resistance ctl treated particleboard control sample treated specimens bfca acq high biological resistance microcerotermes diversus anacanthotermes vagans termites percent weight losses respectively weak mechanical strength internal bond related bfca treated particleboard mpa acq treated particleboard strength mpa similar control sample mpa highest strength value mpa obtained particleboard made ctl general acq treated particleboard indicated better performance others particleboard elsevier ltd rights reserved
bladder mucosa comprised multilayered urothelium lamina propria microvasculature smooth muscle fibers muscularis mucosae muscularis mucosae always present mucosa presence related thickness since mucus secreting cells mucosa imprecise term nerve fibers present mucosa efferent nerves mediate mucosal contractions elicited electrical field stimulation efs various agonists source mucosal contractility unknown may arise muscularis mucosae myofibroblasts efs also increases frequency mucosal venule contractions thus efferent neural activity multiple effects mucosa afferent activity measured mucosa stimulated mechanical stretch stimuli luminal side nerve fibers shown penetrate urothelium allowing urothelial cells interact nerves myofibroblasts specialized cells within generate spontaneous electrical activity modulate afferent efferent neural activities thus mucosal signaling defined interactions bladder autonomic nerves non neuronal cells within mucosa mucosal signaling likely involved clinical functional hypersensory bladder disorders overactive bladder urgency urgency incontinence bladder pain syndrome mechanisms poorly understood despite high prevalence conditions targeting aberrant mucosal signaling could represent new approach treating disorders elsevier rights reserved
blood brain barrier bbb critical contributor brain function understand development potential function different brain regions postnatal bbb investigated mouse cortex ctx lateral hypothalamus paraventricular nucleus hypothalamus pvn brains examined postnatal days bbb competency pericytes key cellular components bbb demarcated immunoreactive desmin glucocorticoid influences excess dexamethasone dex prenatal development also assessed impact blood vessels within regions postnatally significantly extravascular leakage low molecular weight dye fluorescein isothiocyanate ctx within hypothalamic regions pericytes low levels desmin immunoreactivity increased age regions desmin immunoreactivity present pvn age examined fetal dex exposure resulted decreased blood vessel density within pvn ctx dex exposure increased bbb competency contrast pvn decrease bbb competency increased pericyte presence overall unique alterations functioning bbb within pvn may provide novel mechanism fetal antecedent programming may influence adult disorders
boundary scan technology make virtual probing could improve overall testability product provide effective approach pcb automatic testing based bus paper new boundary scan cell insertion algorithm put forward grounded simplified test signal flow graph sfg modeling board algorithm uses testability measure based controllability observability evaluate every node defined according distance nodes primary last example given verify algorithm conclusion algorithm paper solve placement problem boundary scan cell pcb automatic testing using boundary scan buses important application value
bronchial airway epithelial cell baec site initial encounters inhaled environmental factors lower respiratory system hypothesis release pro inflammatory interleukins primary baec cultured children increased vitro exposure common environmental factors primary baec obtained children undergoing clinically indicated routine general anaesthetic procedures cells exposed three different concentrations lipopolysaccharide lps house dust mite allergen hdm particulates extracted side stream cigarette smoke sscs baec obtained children mean age years exposed stimuli compared negative control increase release exposure hdm comparisons reduced higher compared lower sscs exposure change baec release lps exposure baec children able recognise respond vitro enhanced pro inflammatory mediator secretion inhaled exposures
capstone design course senior level course large number civil engineering construction programs course bridges gap education industry emphasizing project based learning asking students accomplish open ended project planning system design study aims investigate potential incorporating service learning capstone courses civil engineering construction engineering construction management curricula accomplish objective questionnaire designed distributed among alumni purdue university well durham school architecture engineering construction questionnaire asking main learning objectives current capstone courses objectives better covered service learning project practical efficient systematic way incorporate service learning capstone courses results study used successfully incorporate service learning advanced authentic performance task capstone senior design course increase student experience real world issues enhance required skills project management project planning cost analysis estimation
carbon dots got much attention recently considering environment protection green materials urgent paper nitrogen sulfur doped carbon dots cds prepared one pot simple convenient hydrothermal carbonization approach green ginkgo leaves materials synthesized carbon dots successfully doped nitrogen sulfur elements fluorescence intensities carbon dots rather stable different ionic strength furthermore green cds successfully applied bioimaging fluorescent probes due excellent optical properties low cytotoxicity elsevier rights reserved
case study examines possibility creating park slow fast charging stations urban area high population density criteria placement charging stations park number determined three transformer substations based utilization established studies conducted using simulink virtual model analysis indicated creation park service stations additional load transformer substations cause overload electrical network affect quality electricity
caudal part neural tube developed spinal cord cvrl days clearly differentiated ependymal mantle marginal layers cvrl days onwards cilia present ependymal cells lining central canal stage mantle layer appeared roof floor plate showed different stages developing neurons supporting neuroglial cells cvrl days buffalo foeti white matter became thick loose consistency cvrl
cell surface hydrophobicity csh assessable physicochemical property used evaluate microbial adhesion surface biomaterials essential step microbial biofilm formation pathogenesis present vitro fermentation experiment csh ruminal mixed microbes considered along data records ammonia nitrogen concentration neutral detergent fibre digestibility conditions surface tension specific surface area two different time scales dataset perturbations input variables grouped two blocks data constructed next expected measurement moving average machine learning emma models developed order predict csh perturbations input variables emma perturbation theory method combines ideas expected measurement box jenkins operators moving average time series analysis seven regression methods tested multiple linear regression generalized linear model stepwise feature selection partial least squares regression lasso regression elastic net regression neural networks regression random forests best regression performance obtained emma model squared model analysis shown csh values highly dependent vitro fermentation parameters detergent fibre digestibility ammonia nitrogen concentration expected values cell surface hydrophobicity first time scale elsevier ltd rights reserved
cellulose electro active paper eapap discovered smart material used sensors actuators flexible electronics eapap made regenerated cellulose requires dissolving cellulose pulp using solvents heating process however heating process dissolving cellulose critical performance eapap paper introduce new fabrication process cellulose eapap pretreatment process cellulose simplifies fabrication process require heating process pretreatment process includes first immersion cellulose deionized water second immersion dimethylacetamide dmac solvent followed twice repeat immersions pretreated cellulose dissolved using lithium chloride licl dmac solvent without heating gives cellulose solution pretreated cellulose solution compared another cellulose solution made licl dmac solvent heating process terms viscosity solubility cellulose eapap samples made using two cellulose solutions physical electromechanical properties compared terms transparency ion concentration surface morphology young modulus dielectric constant piezoelectric charge constant pretreatment cellulose results similar better physical properties eapap simplifies cellulose eapap fabrication
challenge raised introduction internet things iot concept permanently shape networking communications landscape therefore significant social impact ongoing iot research activities directed towards definition design open architectures standards still many issues requiring global consensus final deployment paper presents discusses iot architectural frameworks proposed ongoing standardization efforts design issues terms iot hardware software components well iot application domain representatives smart cities healthcare agriculture nano scale applications addressed within concept internet nano things order obtain performances related recently proposed protocols emerging industrial internet things applications preliminary results message queuing telemetry transport time slotted channel hopping protocols provided testing performed openmote hardware platform two iot operating systems contiki openwsn
chemical modifications hydroxyl group dalbergin described via introduction cyclic amine ester amide groups among twenty three prepared novel analogues dalbergin compound showed significantly increased proliferation assessed alkaline phosphatase activity mineralization calvarial osteoblast cells vitro compound dose body weight exhibited significant osteoprotective effect showed significant increase osteogenic gene expression runx similar fold alp similar fold ocn similar fold col similar fold compared control group dose vivo assay elsevier ltd rights reserved
chronic chikungunya arthritis symptoms closely mimic rheumatoid arthritis symptoms thus making difficult distinguish two clinical entities current comparative study characterizes like cell responses patients chronic chikungunya arthritis phenotype functions like cells repertoire assessed chronic chikungunya arthritis patients controls using flow cytometry tnf alpha ifn gamma secreting like cells high chronic arthritis patients controls percentage tnf alpha cells higher patients controls percentage perforin cells low chronic arthritis patient groups among patient groups expressions perforin ifn gamma like cells higher overall data show reduced frequency like cells lower expression perforin higher expression tnf alpha like ifn gamma like cells markers chronic arthritic diseases absence specific treatment chronic chikungunya induced arthritis promising results anti tnf alpha therapy current data may form basis future vivo studies scope possible therapeutics chikungunya american society histocompatibility immunogenetics published elsevier inc rights reserved
class vehicles move air underwater great interest decades novel water air unmanned vehicle double quadrotor structure designed study air power mechanism works vehicle flies air whereas water power mechanism works moves underwater water entry process water air unmanned vehicle requires accurate attitude height control vehicle may bounce overturn however force resisting descent known ground effect affect stability ground effect formula water entry process derived experiments water entry dynamic model improved time active disturbance rejection controller adrc designed control water entry attitude height experimental results obtained comparison adrc proportional integral derivative pid controller show adrc designed study robust pid controller internal coupling external disturbance vehicle moreover adrc meet requirements rapid attitude adjustment accurate height control
classic way building software today simplistically consists connecting piece code calling method piece code implementing method consider piece code software systems calling anything behaving non deterministic way providing complex sets services different domains software engineering reusability holly grail specially reusability code autonomus tools requires powerful compostion integration mechanisms systems developed different developers modified inceremently integrating autonomous tools generate various conflicts deal conflicts current integration mechanisms defines specific set rules resolve conflicts accompalish integration indeed still big chance changes made developers update changes order make compliant developers cancel updates done others approach presented claims three contributions field hetrogeneous software integration first approach eliminate need conflicts resolving mechanism secondly provides mechanism work presence conflicts without resolving finally contribution integration mechanism affect either system evolves introducing intermediate virtual layer two systems introduce delta models consist three parts viability share required elements hiding hide conflicting elements aliasing aliases concepts systems
classical objective obfuscation considers indistinguishability obtained code relation original programs equal functionality present paper reviews another objective obfuscation indistinguishability considered relatively programs different functionality case obfuscator provided key input nearly impossible discover program functionality without key hence obfuscator type named key obfuscator paper proves existence key obfuscator existence effective algorithms operation demonstrated recursive functions practical relevance result obtained research possibility store executable code untrusted computational environment obstruct injection attacks distributed computing analysis rkb obfuscator recursive key blur application obfuscating high level applications presented presented application matches recursive functions commands high level programming language
clinical copd questionnaire ccq recommended global initiative chronic obstructive lung disease gold evaluate health status patients copd objective work systemically assess reliability validity responsiveness minimum clinically important difference mcid ccq structured search conducted three databases identify articles evaluated psychometric properties ccq individuals copd two investigators screened title abstract full text articles determine study eligibility performed data extraction quality assessment included studies assessed cosmin consensus based standards selection health measurement instruments checklist finally studies included half fair methodological quality internal consistency reliability ccq total score ranged test retest reliability overall ccq better correlation george respiratory questionnaire sgrq copd assessment test cat modified medical research council mmrc forced expiratory volume fev predicted scores different within gold stages groups composite events morbidities ccq sensitive exacerbations pulmonary rehabilitation smoking cessation mcid ccq useful practical tool used clinical populations good reliability validity responsiveness interventions
clinical importance peanut arachis hypogaea allergies demands standardized allergen extraction protocols determined effectiveness common extraction conditions buffers defatting reagents extraction time temperatures processing extraction repeats crude protein ara yields despite similar gel profiles defatting hexane resulted significantly higher yields crude protein ara ara diethyl ether yields affected composition extraction buffers conditions crude protein yield always correlate ara yields denaturants reducing agents acidic buffers thermal processing peanuts perturbed allergen quantification elisas probably via exposure additional epitopes allergen detection western blots pbs resulted greater sensitivity tbs tris recommend allergen extraction conditions selected based research question investigated elsevier ltd rights reserved
coexistence psoriasis systemic lupus erythematosus sle reported limited case series raising hypotheses shared pathogenetic mechanisms nevertheless important differences regarding treatment exist aim present study determine prevalence characteristics psoriasis defined cohort lupus patients patients psoriasis retrieved university toronto lupus clinic inception charts hand searched collect information concerning demographic clinical therapeutic variables patients matched non psoriasis lupus patients identify impact supervening psoriasis lupus activity damage accrual venous thromboembolic vtes cardiovascular events cves psoriasis diagnosed patients females males prevalence male female ratio significantly higher non psoriasis patients plaque psoriasis prominent type whereas three patients pustular disease one psoriatic arthritis nine patients administered systemic treatment methotrexate azathioprine ustekinumab etanercept psoriasis definitely deteriorated hydroxychloroquine one patient significant impact psoriasis disease activity damage accrual vtes cves prevalence psoriasis twice high general canadian population lupus cohort plaque psoriasis prominent subtype topical treatment adequate majority patients supervening psoriasis significant impact lupus activity damage accrual
cognitive load placed users proactive spontaneous provisioning service functionality physical activities performed ambient intelligence environments lead depletion mental resources paper demonstrates burdening inappropriate selection service functionality users conducting semi naturalistic controlled user test investigate significance cognitive resource depletion problem specific ambient intelligence environments dynamic service binding scheduling mechanism provided based different types interference mental resources demand requirements technical evaluation conducted simulating mechanism set various abstract service compositions making use real datasets user interactions diverse hci services daily physical activities results show mechanism ensures less cognitively taxing unobtrusive service composition provisioning
combined supplementation medium chain triglycerides mcts leucine rich amino acids cholecalciferol vitamin increase muscle strength function frail elderly individuals however effects cognition unknown enrolled elderly nursing home residents mean age randomized controlled parallel group trial participants randomly allocated groups first group received leucine cholecalciferol enriched supplement mct mct second group received supplement long chain triglycerides lct third group receive supplements control cognition assessed baseline intervention difference changes among groups assessed ancova adjusting age baseline value covariates mini mental state examination mmse score mct group increased points nishimura geriatric rating scale mental status scale score mct group increased points whereas lct control groups decreased points points respectively combined supplementation mcts leucine rich amino acids cholecalciferol may improve cognitive function frail elderly individuals
commonly used inhalation anesthetic sevoflurane previously demonstrated induce apoptosis developing brain however underlying molecular mechanisms remain largely unknown micrornas mirnas serve important roles multiple physiological pathological processes cell death survival present study mirna sequence closely associated sevoflurane induced apoptosis hippocampus neonatal rat brains identified seven day old sprague dawley rats first exposed sevoflurane hippocampal brain tissues harvested following sevoflurane exposure cleaved caspase levels examined using immunofluorescence assay alterations mirna expression assessed microarray analysis reverse transcription quantitative polymerase chain reaction protein levels phosphorylated cell lymphoma bcl bax assessed western blot analysis sevoflurane exposure significantly increased levels cleaved caspase hippocampus addition among mirnas observed expressed hippocampus sevoflurane exposure altered expression levels mirnas among differentially expressed mirnas eight significantly upregulated one mirna significantly downregulated following sevoflurane exposure bioinformatics analyses indicated mirna direct downstream target sevoflurane exposure induced significant alterations level bcl bax hippocampus neonatal rats conclusion results present study suggest mirna may regulated involved sevoflurane induced neural apoptosis hippocampus developing rat brains potentially via mitochondrial pathway
comparison sets genome intervals genes repeats chip seq peaks essential genome research especially modern sequencing technologies enable ever larger complex experiments relationships genomic features commonly identified intersection feature sets contain overlapping intervals inferred share common biological function origin using technique researchers identify genomic regions common among multiple unique individuals data sets recent advances algorithms pairwise intersections two sets genomic intervals advances made intersection many sets genomic intervals identifying intersections among many interval sets particularly important attempting distill biological insights massive multidimensional data sets common modern genome research analyses speed efficiency crucial given size sheer number data sets involved solve problem present novel slice sweep algorithm given interval sets efficiently reveals subset intervals common sets demonstrate algorithm efficient sequential case vastly higher capacity parallelization speedup existing algorithm
complement cascade plays role synaptic pruning synaptic plasticity seem involved cognitive functions psychiatric disorders genetic variants closely related csmd csmd genes implicated complement regulation associated schizophrenia since patients schizophrenia often show cognitive impairments tested whether variants csmd csmd also associated cognitive functions per took discovery replication approach using well characterized scandinavian cohorts total snps csmd snps csmd tested association cognitive functions ncng sample norwegian cognitive neurogenetics replication testing snps value csmd csmd carried top sample thematically organized psychosis betula sample betula longitudinal study aging memory dementia finally conducted meta analysis snps using three samples previously identified schizophrenia marker csmd snp also included strongest association observed csmdi snp performance immediate episodic memory value chi minor allele maf negative direction effect association reached study wide significance level chi snp significantly associated cognitive functions samples conclusion studied individuals found evidence variant csmd associated cognitive function additional studies larger samples cognitive phenotypes needed clarify role csmd cognitive phenotypes health disease authors published elsevier inc
complex pathophysiology involved migraine necessitates drug treatment act several receptors simultaneously present investigation attempt discover unidentified anti migraine activity already marketed drugs shared featured pharmacophore modeling employed purpose six target receptors beta adrenoceptor dopamine trpv iglur kainate cgrp resulting generation five shared featured pharmacophores subjected virtual screening ligands obtained drugbank database molecular docking performed obtained hit compounds virtual screening indicated nystatin active lead receptors iglur kainate receptor vso cgrp beta adrenoceptor nya dopamine pbl high binding energy kcal mole respectively anti migraine activity nystatin adjudged fabricating brain targeted chitosan nanoparticles brain targeting efficacy analyzed qualitatively confocal laser scanning microscopy demonstrated significant amount drug reaching brain pharmacodynamic models swiss male albino mice revealed significant anti migraine activity nanoformulation present study reports first time therapeutic potential nystatin migraine management hence opening avenues future exploration elsevier rights reserved
complexity data methods industrial ecology keeps growing demand comprehensive interdisciplinary assessments increases keep development field needs data infrastructure allows researchers annotate store retrieve combine exchange data low cost without loss information across disciplines model frameworks consensus building debate describe common object study socioeconomic metabolism sem necessary development practical data structures databases review definitions basic concepts describe sem related fields integrated assessment modeling find many definitions compatible implicit sometimes lacking resolve conflicts inconsistencies within current definitions propose hierarchical system terms definitions practical ontology describing objects properties events sem propose typology object properties use sets group objects hierarchical mutually exclusive collectively exhaustive mece classification grouping leads general definition stocks show mece representation events necessarily requires two complementary concepts processes flows propose general definitions based sets using definitions show system structure interdisciplinary model sem formulated directed graph propose guidelines semantic data annotation database design help turn vision powerful data infrastructure sem research reality
complexity products increasing functions structures included leading higher requirements better understand users behaviour term using product early engineering design phase although industry academia agree human aspects important success product methods support designers concerning factors synthesis design process article describes behaviour design approach bda used industrial engineers designers ergonomists ergonomic analysis evaluation product machine design approach developed expert non expert practitioners integrate user behaviour product behaviour design phase improving product performance
concept attachment long term interpersonal relationships linked relationship outcome social emotional health date relationship structural properties human amygdala attachment romantic relationships measured self reported attachment related anxiety avoidance described aim current study investigate relationship amygdala structure well amygdala structural functional connectivity attachment anxiety avoidance end collected self report attachment data sample female young adults examined associations attachment mean diffusivity fractional anisotropy resting state functional connectivity mri amygdala white matter connections prefrontal cortex found lower integrity left amygdala linked attachment avoidance less comfortable seeking proximity others depending others greater structural integrity uncinate fasciculus positively associated avoidance lastly found stronger bilateral amygdala medial prefrontal regions linked greater avoidance findings compatible expand previous results reported studies taken task related fmri approach furthering understanding neurobiological mechanisms attachment particular implicating system formed amygdala prefrontal areas patterns behavior regulate emotional proximity romantic relationships findings potential understanding affective mechanisms underlying attachment behavior
concept emotional eating increasingly considered implicated overeating obesity different subtypes eating disorders among self report questionnaires assessing emotional appetite questionnaire emaq includes recent advances area evaluates broad range emotions situations positive negative way modulate food intake decrease stability increase main objective study investigate psychometric properties french version emaq large sample students participants completed emaq debq dutch eating behavior questionnaire cidi eating disorders screening composite international diagnostic interview factorial structure reliability validity emaq tested factorial analyses supported two factor positive negative structure internal consistency indices satisfactory results suggest good test retest reliability scale convergent discriminant validity confirmed significant correlations observed emaq scores debq subscale scores regarding associations weight whereas emaq negative scores positively correlated bmi emaq positive scores negatively correlated bmi finally emaq scores differed significantly depending gender risk bulimia nervosa study supports validity reliability emaq appears promising instrument better understand individual differences could modulate food intake
concept empathy received much attention philosophers also cognitive social psychologists however given widely conflicting definitions taking primarily epistemological notion others social one recently empathy closely associated simulationist approach social cognition might thought concept utility stands falls simulation suggest mistake approaching question empathy via question claim empathy plays distinctive epistemological role alone allows know others feel independent plausibility simulationism generally view propose inclusive definition empathy one likely consequence empathy natural kind follows pace number empathy researchers certain experimental paradigms tell nature empathy certain ways empathy achieved end briefly speculating empathy conceived may also play distinctive social role enabling term transparent fellow feeling
concept green building gained rapid recognition recently developed green building council leadership energy environmental design leed one successful green building rating systems understanding performance leed certified buildings various leed credits therefore important practitioners regulatory authorities paper analyses use leed investigates credit allocation pattern leed certified projects results show compared previous version leed point chasing problem innovation related credits mitigated however energy related material related credits remain difficult developers obtain leed certified projects perform differently water efficiency country level state level projects perform differently water efficiency energy atmosphere material resources well indoor environmental quality varied credit achievement patterns also identified cross certification cross sector levels study offers useful guidance practitioners achieve relevant certification levels regulatory authorities continuously improve rating system
concept stereotype important topics social psychology closely related prejudice discrimination stereotypes may drag people generalization failure judgements addition many unwanted behavioral outcomes first section article deals definition concept stereotype ascertains motives individuals intend acting accordance stereotypes followed offering various solutions problem second section points effect stereotypes interpretation social judgement social cognition third section dwells stereotypes changed study presents summary researches stereotype social judgement importance terms indicating stereotypes turn prejudices eventually cause discrimination
consensus definition late presentation human immunodeficiency virus patient based threshold cells limitations concerning risk factors identification since growing biomedical justification earlier initiation treatment objective overcome problem simultaneously determining factors associated different levels counts time diagnosis january july patients first human immunodeficiency virus diagnosis entering care french human immunodeficiency virus reference center enrolled factors associated percentile quantile counts diagnosis simultaneously studied multivariable quantile regression model quantiles factors identified negatively associated count diagnosis older age male sex foreign patients hepatitis virus hepatitis virus infection employment status non msm transmission heterosexual transmission suburban rural place residence earlier period diagnosis association count uniformly significant factors significant quantiles significant determinant quantiles born foreign country results particularly helpful context human immunodeficiency virus clinical care management prevention
conservation water agriculture requires understanding mechanisms plant water relations study aimed reveal hydraulic regulation strategies maize zea mays maintaining plant water balance drought water relations two maize inbred lines tian differ resistance drought field investigated well watered conditions osmotic stress induced peg leaf transpiration rate leaf water potential varied diurnally remained constant tian drought resistant tian plants showed morphological anatomical physiological advantages protected foliar water loss strategies leaf hydraulics regulate leaf water balance day short term osmotic stress also differed tian leaf hydraulic conductivity tian increased temporarily root hydraulic conductivities reduced osmotic stress however root hydraulic conductivity tian subsequently recovered lower rapidly reduced leaf transpiration ability root hydraulics recover short term osmotic stress help explain strategies plant water balance drought tolerant maize
consideration worker heterogeneity assembly lines received fair amount attention literature past decade exploration uses motivation example assembly lines sheltered work centers disabled recently community started looking situation faced assembly lines general industrial park presence worker heterogeneity step raises number questions around best way incorporate heterogeneous workers line maximizing integration maintaining productivity levels paper propose use miltenburg regularity criterion cycle time metrics integration workers productivity respectively define model develop heuristics line balancing problem two goals results obtained extensive set computational experiments indicate good planning obtain trade solutions perform well objectives elsevier ltd rights reserved
construction industry south africa worldwide generates disproportionate number fatalities injuries associated disease direct indirect cost contributes cumulative cost construction many injuries musculoskeletal related form sprains strains arising handling materials process managed inter alia civil engineers furthermore civil engineers designers influence construction ergonomics specification materials related methods purpose paper present results study conducted among civil engineering students south african university objectives determine knowledge perceptions relative mass density materials construction ergonomics following constitute salient results knowledge relative mass density materials limited students appreciate mass density materials impacts construction ergonomics students rate knowledge mass density materials limited opposed extensive students appreciate potential consideration mass density materials contribute improvement construction ergonomics conclusions include students lack knowledge awareness relative mass density materials students precluded conducting optimum design hazard identification risk assessments civil engineering education must reviewed terms addressing referring construction health safety ergonomics subjects authors published elsevier
construction industry one risky workplaces attributable complexity dynamic nature construction activities high rise building construction remains predominant high accident rates counted yearly site specific assessment tool considers characteristics changeable conditions currently managed construction site necessary precisely assess safety risks therefore study aims address significant safety risks principal factors associated high rise building construction projects malaysia responses obtained within construction management personnel evaluated using factor analysis understand latent critical risk factors preliminary findings suggest safety risks significant working environment identified critical principal factor consists diverse underlying safety risks high loading factors successful investigations study lead development high rise building construction safety health risk model practical view findings assist high rise construction project participants attentive health safety issues
construction large software systems always achieved assembly independently written components program modules software components work together must share common set data types principles representing structured data arrays values files common set tools creating operating data objects provided infrastructure computer system hardware operating system runtime code nature properties tools crucial correct operation software components inter operation essential precise specification may used verifying correctness application software one hand verify correctness system behavior call specification program execution model pxm evident properties pxm implemented computer system serious impact ability application programmers practice modular software construction paper discusses concept program execution models presents set principles pxm must satisfy provide sound basis modular software construction parallel program execution computer systems many processing units essential part contemporary computing environments expression parallelism modular software construction using components involving parallel operations included treatment conclusion possible build computer systems implement pxm within parallel program may used unmodified component building substantial parallel programs
containers used steel slag transportation recycling depot undergo high temperature gradients often deform plastically also parts thereby solidified slag adhere pot walls causing demolding problems wear thorough finite element analysis heat transfer initiated filling pots essentially driven radiation thermal stresses performed due periodic fill discharge assumed admit quasi stationary state referring pot temperature emptying obtained results aid optimizing pot shape transport process terms minimizing maintenance anti adhesive cladding layer solidified slag found exist throughout transport process although phase change occurs almost instantaneously liquid solid interface mushy zone considered accompanying analytical study associated stefan type problem good correlations predicted temperatures measured ones resultant surface damaging obtained
control algorithms software implementation play crucial role real time embedded systems reliability safety field programmable gate arrays fpga based hardware loop hil relatively new technique used development testing hard real time complex systems system simulator implemented fpga provides real time reactions control system actuations aim work present hil simulator squirrel cage induction motor drive control algorithm development testing real time conditions testing platform consists target microcontroller unit implemented software drive control connected real time fpga simulator drive
control wind power plant operating isolated power source analyzed plant consists wind turbine three phase synchronous electric generator connected means gear box mathematical models wind turbine electrical generator indicated use estimator based adaptive fuzzy logic control technique govern system proposed results control test case shown order demonstrate reliability proposed control technique elsevier science ltd rights reserved
control systems course taught educational electric engineering programs world method used teaching course mainly mathematical representation software simulation systems behavior work author presents different approach based making hands experimental applications solution presented article based decomposing arranging transfer function representation dynamic system order implement using electronic circuits combining presented method popular simulation software leads implementation practical effective laboratory classes course
controller design bilateral teleoperation systems involves delicate trade performance stability achieve high performance high order robust controllers may feasible real time implementation hardware computational limitations main purpose paper achieve stability transparency presence time delay communication channel well model uncertainty address problems novel robust fixed structure controller proposed uncertain bilateral teleoperation systems traditional conventional proportional integral derivative pid controller employed achieve requirements simplicity straightforward design significant advantageous proposed method robust stability analysis proposed technique also provided results demonstrate structure effective providing stability transparency teleoperation systems
conventional wisdom brazil foreign policy policy state part daily political debate result understanding foreign policy largely driven foreign ministry president generally taking role needed advance particular initiative presidential diplomacy challenge assumptions arguing engagement authority president essential factors bringing substantive strategic change brazilian foreign policy also alterations policy process democratized foreign policy moved policy state another area public policy draw deepen sergio danese theory presidential diplomacy map major strategic changes post authoritarian brazil foreign policy find major changes taken place initiated truncated fernando collor presidency deepened amplified highly internationally engaged presidencies fernando henrique cardoso lula contrast presidencies itamar franco dilma rousseff emerge instances inertial continuity lacking dynamism innovation
coupled cubic quintic nonlinear schrodinger equations fiber optics describe effects quintic nonlinearity ultrashort optical pulse propagation non kerr media investigated using symbolic computation derive dark bright soliton solutions equations virtue asymptotic analysis graphical analysis overtaking head elastic interactions two bright dark solitons presented mixed bound state solitons also arise solitons propagate parallel displaying beating effects due oscillatory terms displaying breather like structures
crystal structure nmr spectroscopy complex impedance carried scn chn crystal structure shows polymeric network built two crystallographically independent cadmium atoms two different octahedral coordinations compound exhibits phase transition characterized differential scanning calorimetry dsc rays powder diffraction conductivity dielectric measurements examination mas line shapes shows indirect spin spin coupling dipolar coupling constant conductivity compound carried temperature range frequency range mhz impedance data well fitted two equivalent electrical circuits results modulus study reveal presence two distinct relaxation processes one low frequency side thermally activated due ionic conduction crystal higher frequency side gradually disappears temperature reaches attributed localized dipoles crystal moreover temperature dependence conductivity phases follows arrhenius law frequency dependence sigma omega follows jonscher universal law near values activation energies obtained conductivity data impedance confirm transport ion hopping mechanism elsevier ltd rights reserved
current article reports perpetrator characteristics gathered first large scale prevalence study interpersonal violence children sport netherlands belgium using retrospective web survey design adults answered questions experiences youth sport study looks number perpetrators well individual descriptive characteristics sex age role sport organization perpetrators psychological physical sexual violence reported retrospectively victim respondents information clustered provide overview common perpetrator profiles results show types interpersonal violence sport perpetrators predominantly male peer athletes frequently operate together impromptu groups several differences three types interpersonal violence highlighted incidents physical violence perpetrated coaches tend less severe compared perpetrators acts sexual violence committed coach significantly severe presented findings shed new light perpetrators interpersonal violence sport nuancing predominant belief male coach main perpetrator providing nuanced information utilized improve prevention child protection measures safeguarding initiatives sport elsevier ltd rights reserved
current business market characterized rapid continuous changes companies adapt new situations guarantee sustainable development managers need capabilities understand new environment requirements managers individual dynamic capabilities idc help face unpredictable changes market however authors analysed individual dynamic capabilities ensure business sustainability study aims shed light relationship manager idc business sustainability gender perspective survey managers conducted structural equation modelling sem applied study impact relationship results show managers individual dynamic capabilities help detect changes market earlier promote greater social environmental commitment managers addition significant differences environmental social commitment men women found therefore paper first provides advice developing business sustainability provide advantage organizations second individual dynamic managerial capabilities appear important promoting sustainability finally another step construction gender sustainability provided thus paper provides useful empirical evidence managerial practice strategic management viewpoint elsevier ltd rights reserved
current development area computer graphics focuses visualization direction set contemporary trends utilizes visualization increases quality improves visualization devices graphics change must reflected teaching methods well future specialists advanced graphics modellers also programmers implementation coders article presents software solution innovative approach teaching computer graphics solution principles based montessori method child education
current feedback instrumentation amplifier cfia designed eeg detection systems presented cfia includes two digitally programmable operational transconductance amplifiers dpotas current feedback operational amplifier cfoa digital control dpota done using bit current division network cdn pspice simulation results carried using ibm cmos process supply voltage cfia reaches common mode rejection ratio cmrr consumes root input referred noise achieved gain results make cfia suitable eeg detection systems
current research expands upon sparse existing literature nature bias interracial couples study demonstrates bias interracial romance correlated disgust study provides evidence images interracial couples evoke neural disgust response among observers indicated increased insula activation relative images race couples consistent psychological theory indicating disgust leads dehumanization study demonstrates manipulating disgust leads implicit dehumanization interracial couples overall current findings provide evidence interracial couples elicit disgust dehumanized relative race couples findings particularly concerning given evidence antisocial reactions aggression perpetration violence dehumanized targets findings also highlight role meaningful social units couples person perception important consideration psychologists conducting social cognition research elsevier inc rights reserved
current study aimed investigate specific pathways offence process mentally disordered firesetters previous study offence chain model constructed firesetting offence chain mentally disordered offenders foc using offence descriptions obtained mentally disordered firesetters detailing sequence contextual behavioural affective cognitive factors precipitate incidence firesetting population current study examines prevalence specific pathways firesetting original mentally disordered firesetters sample mentally disordered firesetters three distinct pathways firesetting identified within foc fire interest childhood mental health fire interest adult mental health fire interest adult mental health article describe three pathways detail using illustrative case studies practice implications identified pathways also discussed
current study examined associations mothers behavioral profiles mother child conflict interactions children social skills person centered approach classified mothers according levels emotional responsiveness intrusiveness negativity engagement facilitation behaviors eight minute conflict discussion task child three distinct classes mothers identified using latent profile analysis sensitive engaged moderately sensitive engaged insensitive disengaged analysis covariance indicated children mothers sensitive engaged group significantly higher social skills children mothers moderately sensitive engaged insensitive disengaged groups results suggest mother child conflict interactions may benefit children social development mothers facilitate children participation highly sensitive manner
current study examined complex associations among marital status home environments family strain income maternal depressive symptoms social support parenting stress predict preschool children pre academic social skills months findings nichd study early child care youth development showed home learning environment significantly lower among single parent families worked mediator explain relationship single parent families children pre academic skills months additionally parenting stress significantly higher among single parent families worked mediator explain relationship single status home learning environment finally moderation analyses showed family income important improving home social environment home social environment strongly associated children social skills single parent families cohabiting families copyright john wiley sons ltd
current study examines discrete emotions function manifestation third person effect news coverage election poll results online survey conducted employing sample undergraduate students united states south korea presidential elections two countries results demonstrate third person perception negatively associated pride turn positively linked political participation intention supporters losing candidate respondents third person perception positively associated anger positively associated support restrictions polling news south korean respondents mediation anxiety third person perception political participation intention significant supporters losing candidate implications findings discussed
current study integrated constructs fields relationship science similarity familiarity intergroup research racial ideologies particularly color blind racial ideology multiculturalism explore interracial romantic attraction using person perception design black white heterosexual college men indicated romantic attraction dating profiles three black three white women results analyses consistent linear mixed model approach supported hypotheses including participants general attracted women race greater endorsement multicultural ideological beliefs associated increased interracial attraction white men greater endorsement color blind racial ideology predictive decrease interracial romantic attraction hypothesized contrary hypotheses increased interracial contact black men associated increase race attraction results discussed context existing literature important next steps also discussed
current study investigated relationship suicide homicide rates internationally database mortality data countries concerning suicide homicides cancer traffic accidents controls used analysis included pearson correlation multiple linear regression analysis worldwide homicidal rates explained male female suicides respectively europe positive correlation male suicide rates homicide rates including homicide rates genders male victims female victims america significant correlation asia significant correlation male suicidal rates homicide rates female victims observed marked interesting differences pattern association europe americas overall current paper suggests least human populations suicidality homicidality share common etiopathogenetic substrates could triggered internal external events might develop based common genetic background empirically suggested suicide related higher living standards murder related poor quality life lower living standards
current study investigated validity revised item version driving anger expression inventory dax novel sample drivers ukraine roles sex gender relation self reported aggressive tendencies also examined confirmatory factor analysis supported four factor structure dax adaptive constructive expression use vehicle express anger verbal aggressive expression personal physical aggressive expression three aggressive factors found positive relationships trait anger driving anger adaptive constructive expression negatively related trait driving anger drivers reported recent near misses loss concentration scored higher verbal aggressive expression recently received traffic ticket also reported higher levels three types aggressive anger expression presence feminine traits sex predicted adaptive constructive behaviors lower scores verbal aggressive expression personal physical aggressive expression total aggressive expression however masculine traits predict factors research concludes revised dax valid tool measure expression driving anger endorsement feminine traits related less aggressive expression driving anger
current study investigated whether multidimensional model could underlie impulsivity associations various disorders forensic sample data available self report behavioral impulsivity instruments forensic patients principal component analysis pca used derive dimensional impulsivity model relationship possible predictive validity impulsivity dimensions psychopathology investigated using product moment correlations regression analysis dimensional model impulsivity derived factors labeled impulsive decision making sensation seeking response inhibition impulsive decision making predictor history drug dependence impulsive lifestyle facet psychopathy antisocial personality disorder sensation seeking related psychopathology inadequate response inhibition predictor drug dependence psychopathy antisocial personality disorder given importance concept impulsivity regard forensic risk assessment current results replicated earlier impulsivity models imply impulsivity crucial target diagnosis interventions underlines importance consider impulsivity multidimensional construct
current study presents preliminary evaluation spanish adaptation implicit analog procedure parent child aggression acceptability movie task spanish parent caam based social information processing theory spanish parent caam scores expected relate self reported pca attitudes negative child attributions child abuse risk spanish students undergraduates spain completed spanish parent caam along self report measures pca attitudes negative children attributions inclination punish misbehavior child abuse risk findings indicate spanish parent caam scores significantly related explicit measures pca attributions intentional child misbehavior propensity punish misbehavior increased child abuse potential results considered within cultural context spain corporal punishment ban pca attitudes
current study sought assess acceptability feasibility compassion focused therapy cft group adjunct evidence based outpatient treatment eating disorders examine preliminary efficacy relative treatment usual tau twenty two outpatients various types eating disorders randomly assigned weeks tau tau plus weekly cft groups adapted eating disorder population cft tau participants conditions completed measures self compassion fears compassion shame eating disorder pathology baseline week week week additionally participants receiving cft group completed measures assessing acceptability feasibility group results indicated cft group demonstrated strong acceptability attendance high group retained participants participants rated group positively indicated would likely recommend peers similar symptoms intention treat analyses revealed compared tau condition cft tau condition yielded greater improvements self compassion fears self compassion fears receiving compassion shame eating disorder pathology weeks results suggest group based cft offered conjunction evidence based outpatient tau eating disorders may acceptable feasible efficacious intervention furthermore eating disorder patients appear see benefit observe gains working cft goals overcoming fears compassion developing self compassion accessing compassion others copyright john wiley sons ltd
current study designed explore specific relationship neurologic soft signs nsss characteristics antisocial personality traits adolescents investigate particular nsss linked certain brain regions adolescents antisocial personality traits research conducted adolescents diagnosed asp traits asp trait group using aspd subscale personality diagnostic questionnaire dsm pdq adolescents without traits personality disorder control group nsss assessed using soft sign subscales cambridge neurological inventory adolescents asp traits showed motor coordination sensory integration disinhibition total nsss control group seven nsss including stereognosia right hand finger agnosia graphesthesia hands left right orientation stimulus significantly frequent teenagers asp traits sensory integration positively associated asp traits adolescents antisocial personality traits might abnormalities central nervous system sensory integration might particular indicator antisocial personality disorder elsevier ireland ltd rights reserved
dark triad represented three interrelated personality characteristics thought share dark core associated range negative outcomes investigate link alongside another potent predictor crime low self control analyses found dark triad strongly predictive delinquency especially violent delinquency accounted effects self control yet exerted significant effect drug based delinquency however interaction dark triad low self control remained substantive predictive across models low self control amplified effects dark triad delinquency
death mature oligodendrocytes ols sole myelinating cells central nervous system cns leads demyelination functional deficits currently lack effective remyelination therapies patients demyelinating diseases micrornas mirnas mediate function hypothesized mir inactivating interleukin receptor associated kinase irak promotes differentiation oligodendrocyte progenitor cells opcs thereby enhances remyelination test hypothesis demyelination model induced cuprizone cpz diet employed cbl mice fed cpz diet weeks termination cpz diet mice randomly treated continuous infusion mir mimics mimic controls corpus callosum days compared mimic control infusion mir mimics facilitated remyelination assessed increased myelin basic proteins corpus callosum associated augmentation newly generated mature ols infusion mir mimics also substantially elevated mir levels corpus callosum fluorescently tagged mir mimics mainly detected opcs western blot double immmunofluorescent staining analysis showed mir treatment considerably reduced irak protein levels number irak positive cells respectively collectively data indicate exogenous mir enhances remyelination possibly promoting opcs differentiate myelinated ols via targeting irak ibro published elsevier ltd rights reserved
decreasing cost size video sensors led camera networks becoming pervasive lives however ability analyze images effectively much function quality acquired images paper consider problem automatically controlling fields view individual pan tilt zoom ptz cameras camera network leading improved situation awareness critical targets events region interest network cameras attempts observe entire region interest minimum resolution opportunistically acquiring high resolution images critical events real time since many activities involve groups people interacting important decision network needs make whether focus individuals groups achieved understanding performance video analysis tasks designing camera control strategies improve metric quantifies quality source imagery optimization strategies along distributed implementation proposed theoretical properties analyzed proposed methods bring together computer vision network control ideas performance proposed methodologies discussed herein evaluated real life wireless network ptz capable cameras
default mode network dmn identified reliably rest well performance tasks episodic retrieval future imagining remains unclear network engaged across seemingly distinct conditions though many hypotheses proposed account effects prior generating hypotheses explaining common dmn involvement degree commonality dmn across conditions within individuals must statistically determined test whether dmn truly unitary network equally engaged across rest retrieval future imagining provide test used comparable paradigms self directed uninterrupted thought equal duration across three conditions rest retrieval future imagining within participant design found lower expected pattern similarity dmn functional connectivity across three conditions similarity connectivity accounted total variance partial least squares pls analyses revealed medial temporal regions dmn preferentially coupled one another episodic retrieval future imagining whereas non medial temporal regions dmn medial prefrontal cortex lateral temporal cortex temporal pole preferentially coupled rest results suggest dmn connectivity may flexible previously considered findings line emerging evidence dmn static network engaged commonly across distinct cognitive processes instead dynamic system topographically changing relation ongoing cognitive demands hum brain mapp wiley periodicals inc
department marine materials engineering maritime university szczecin conducted research technology metallic composites focusing composite aluminium foams stabilized ceramic particles one technology enables efficient inexpensive diversified terms foam structure control foam properties foundry technology consisting gas injection liquid metal method requires precise control process parameters especially regarding temperature stabilization well precise injection gas metal process foaming liquid aluminium silicon alloys also conducted using ceramic particles metallic ceramic composite foaming process patent paper presents process structure forming metallic ceramic foams
design method initial topology interior permanent magnet synchronous machine ipmsm hybrid electric vehicle hev propulsion described paper design constraints selected basis limitations imposed machine manufacturer application maximum copper slot fill factor air gap length permanent magnet material limited space available drive trains etc design variables rotor radius stator slot width number turns per phase winding parametric analysis performed various machine topologies cost function connects distribution operating points hev efficiency maps various topologies electrical machine defined obtained parametric results compared find result leading extreme value cost function initial design ipmsm corresponds result considered best initial design
design flywheel system energy storage herein performed model based systems engineering mbse example mechatronic product development innovation relevant advantages mbse applied material mechatronic system activities requirement analysis identification system capabilities definition architecture system validation identified moreover paper aimed investigating critical issues arising mbse tools applied machine design still domain poorly inclined exploit holistic approach trend might related technical difficulties assessing interoperable framework simulators aimed dealing simultaneously functional physical models addition technology scouting looks poorly connected within standard sysml diagrams without introducing additional charts demonstration fruitful impact mbse machine design herein proposed show advantages provided mechatronic integrated system conceived complete trade analysis could supported mbse modeling activity
design high stability voltage controlled current source vccs cervical cancer detection ccd applying electrical bio impedance spectroscopy ebs presented circuit designed simulated fabricated tsmc cmos technology power supply proposed howland current source based self biased complementary folded cascode cfc operational amplifier complying requirements medical electrical equipment international standard abnt nbr iec sinusoidal current peak amplitude settled accordance requirements ebs ccd specifications cfc calculated meet mhz frequency range sinusoidal output current output impedance higher broken vertical bar mhz frequency post layout simulations run main results output current peak amplitude specified frequency range broken vertical bar load impedance values broken vertical bar output impedance mhz nominal current amplitude variations lower load impedances range broken vertical bar broken vertical bar experimental result maximum non linearity full scale results performance vccs adequate ebs ccd applications
design flow machines still difficult task mainly due large number free geometrical parameters involved thus design optimization techniques applied obtain optimized designs machines work deals optimization radial flow machine rotors pumps turbine novel methodology propeller design proposed based topology optimization method distributes fluid solid design domain extremize defined objective function subjected constraints design objective optimize shape channel two blades rotor minimize energy dissipation vorticity minimize maximize power case pump turbine respectively objective functions combined multi objective function two dimensional finite element derived rotating frame modelling rotor flow behaviour modelling predicts flow field relative two blades rotor without considering influence volute assumed fluid flowing idealized porous medium subjected friction force proportional fluid velocity inverse local permeability porous flow model introduced continuous grey permeability design variable element defines local permeability medium allows transition fluid solid property design optimization problem solved using method moving asymptotes mma numerical examples presented illustrate methodology elsevier rights reserved
design construction experimental evaluation cascade thermoacoustic engine presented paper system designed built constraint inexpensive device meet energy needs people based remote rural areas cost straightforward system point view air atmospheric pressure applied working fluid main resonator tubes constructed conventional polyvinyl chloride pvc pipes device consists one standing wave unit one traveling wave unit connected series topology preferred traveling wave unit provides efficient energy conversion straight line series configuration easy build allows gedeon streaming system designed operate low frequency measured results reasonably good agreement predicted results far system deliver acoustic power carnot efficiency step proposed device applied prime mover driving thermoacoustic refrigerator
deterioration shot sleeve squeeze casting due thermo mechanical fatigue often results lowering reliability availability squeeze casting machine thus reducing productivity meanwhile increasing life cycle maintenance cost paper presents efficient bayesian kriging meta modeling method spatiotemporal prediction data uncertainty non normality target applications controlling deformation optimizing machine design predicting component fatigue cracking thus improving reliability availability mechanical system spatiotemporal kriging model established substitute complicated computer model using numerically simulated data bayesian probabilistic approach developed quantitatively evaluate validity predictive capacity kriging meta model considering data uncertainty anderson darling goodness fit test employed perform normality hypothesis test difference values validation data box cox transformation method utilized convert non normality data purpose facilitating overall validation assessment meta models higher accuracy bayesian confidence measure presented quantify confidence predictive capacity kriging meta models given transformed data procedure proposed implement proposed probabilistic methodology meta modeling model validation non normality response series impact data normality assumption decision threshold parameter quantitative model assessment also investigated using bayesian inference approach effectiveness proposed methodology procedure demonstrated spatiotemporal temperature prediction squeeze casting
determination efficiency electric motor inverter electric vehicle requires power measurements side inverter voltage current signals arise switching operation inverter therefore hardly bandlimited finite bandwidth measurement devices like sensors adcs yields bandwidth limitation measured signals limitation modifies measured signals effect calculated power measurement uncertainty considerations require evaluation relation bandwidth limitation resulting error power measurement relation allows evaluating significance spectral components power calculation decision components relevant must filtered bandwidth limitation paper presents evaluation method determining bandwidth limitation error identifies critical quantities numerical study
development application stealth material technology one key factors develop stealth technology painting type stealth material properties simply process usableness easy regulate extensive concern paper impure smo acrylate coatings prepared using smo carbon nanotubes powder microstructure studied sem furthermore studied radar absorption properties ghz mechanics properties coatings proved absorption effect coatings best thickness coating solid dosage meanwhile mechanics properties films good
development adhesives applied create strong bonds underwater significant challenge materials engineering adhesive intended biomedical applications criteria biocompatibility must met current biomedical adhesive technologies meet needs response designed bioinspired protein system shows promise achieve biocompatible underwater adhesion coupled environmentally responsive behavior smart tuned suit specific application material ely constructed elastinlike polypeptide elp produced high yields escherichia coli coacervate response environmental factors temperature salinity confer wet adhesion utilized design principles marine organisms mussels sandcastle worms expressed ely rich tyrosine upon modification tyrosinase enzyme form mely tyrosine residues converted dihydroxyphenylalanine dopa ely mely exhibit cytocompatibility significant dry adhesion strength mpa modification dopa increases protein adsorption glass provides moderate adhesion strength kpa highly humid environment furthermore elp exhibits tunable phase transition behavior formulated coacervate physiological conditions provides convenient mechanism application underwater finally mely possesses significantly higher adhesion strength dry humid underwater environments compared commercially available fibrin sealant knowledge mely provides strongest bonds rationally designed protein used completely underwater high yields make viable commercial application compared natural adhesive proteins conclusion elp shows great potential new smart underwater adhesive elsevier ltd rights reserved
development building material science light flows green building architectural geonics concept sustainable development poses new challenges researchers one human environment comfort improvement comfort closely related premise microclimate formed result heating ventilation system interaction building materials wall structures traditionally role building materials interaction passive one characterized two properties thermal conductivity vapor permeability increase efficiency engineering systems possible without inclusion building materials process active component known radiation heat exchange plays important role distribution energy indoors heat exchange takes place surfaces infrared range moreover work radiant heating systems based principle significant advantages compared traditional ones great prospects concerning energy consumption reduction heating regard studied issues composite development particular interaction character particular spectrum infrared light
development microelectronic field software allows researchers implement control law miniaturized devices field programmable gate arrays fpga microcontroller control laws may used industrial applications key work design implementation fixed low order controller stm microcontroller order control electronic system main objective controller ensure time response performances settling time overshoot controller parameters obtained resolving non convex optimization problem considering desired closed loop specifications use classical optimization method resolve kind problems may lead local solution obtained solution optimal therefore suggested apply global optimization method order get optimal control law ensure specified time response performances proposed method work generalized geometric programming ggp method method consists transforming mathematical transformations non convex optimization problem convex one implementation proportional integral controller proportional integral derivate pid fixed low order controller real electronic system shows efficiency latter one
development organic materials visible light driven photocatalytic regarded one promising avenues solve environment solar energy utilization issue present one dimensional supramolecular organic nanofibers self assembled carboxy substituent perylene diimide pdi molecule type stacking hydrogen bonding act robust effective photocatalyst organic pollutants degradation water oxidation visible light without apparent need added metal catalysts corroborate highly efficient stable activity supramolecar photocatalyst attributed introduction terminal carboxyl group leads well defined stable type stacking constructs internal electric field supramolecular nanofibers thereby resulting deepening valence band enhancement migration separation efficiency photo induced charge carriers findings may help development semiconducting based organic supramolecular materials applications environment protection water splitting elsevier rights reserved
development photoactive materials self cleaning depolluting qualities hot topic materials science given impact several technologies wide range contexts applications anatase phase titanium dioxide tio largest used photocatalyst increasing applications ranging air quality control renewable energies green building materials zero energy communities yet partially transmissive near infrared nir negatively affects solar reflectance tio containing materials contribution describe unexpected increase anatase near infrared nir reflectance observed environmental exposure unveil complex mechanisms based contact nitric acid generated nox photocatalytic degradation causes partial reduction decrease crystallinity tio may open way introducing multiple environmentally beneficial effects tio pollutants degradation self cleaning energy performance elsevier rights reserved
development reliable precise indoor localization systems would considerably improve ability investigate shopper movements behavior inside retail environments previous approaches used either computer vision technologies analysis signals emitted communication devices beacons computer vision approaches provide higher level accuracy beacons cover wider operational area paper propose sensor fusion approach active radio beacons rgb cameras system used intelligent retail environment cameras already installed purposes allows affordable environment set low operational costs customer indoor localization tracking adopted kalman filter fuse localization data radio signals emitted beacons used track users mobile devices rgb cameras used refine position estimations combing coarse localization datasets active beacons rgb data sparse cameras demonstrate indoor position estimation strongly enhanced aim general framework provide retailers useful information analyzing consumer activities inside store prove robustness approach several tests conducted real indoor showroom analyzing real customers behavior encouraging results elsevier rights reserved
development smart grid increasing scale power system brings pressure conventional power system simulators graphic processing unit features massive concurrent threads excellent floating point performance brings new chance area power system simulation paper introduces hierarchical parallel decomposition algorithm based stratified elimination tree develops graphic processing unit gpu based parallel linear system solver algorithm boost effectiveness solver hybrid improved matrix ordering algorithm proposed reduce height elimination tree basis solver paper implements coarse grained task parallelism analyze several contingencies static security assessment ssa parallel develops two layered parallel ssa program performance proposed parallel ssa program benchmarked tesla gpu using several real world cases whose scale nodes compared serial ssa program runs xeon cpu results case studies show introduced method speedup reaches times greatly accelerate ssa solution
development mammalian neocortex relies heavily subplate proportion cell population varies considerably different mammalian species subplate almost undetectable marsupials forms thin distinct layer mouse rat larger layer carnivores big brained mammals pig highly developed embryonic structure human non human primates evolutionary origin subplate neurons subject current debate hypothesize subplate represents ancestral cortex sauropsids others consider increasingly complex phylogenetic novelty mammalian neocortex review recent work expression several genes originally identified rodent highly differentially expressed subplate relate observations cellular morphology birthdating hodology dorsal cortex dorsal pallium several amniote species based reviewed evidence argue third hypothesis according subplate contains ancestral newly derived cell populations propose mammalian subplate originally derived phylogenetically ancient structure dorsal pallium stem amniotes subsequently expanded additional cell populations synapsid lineage support increasingly complex cortical plate development understanding detailed molecular taxonomy somatodendritic morphology connectivity subplate comparative context contribute identification ancestral newly evolved populations subplate neurons
development trust origin parenting however misleading lump together types trust suppose formed similar developmental processes therefore research examined different developmental pathways adolescents trust individuals close peers study distant politicians study study used longitudinal data collected czech adolescents participants females adolescents years old parents reported parental warmth adolescents rated trust parents beliefs world age well trust peers politicians age maternal paternal warmth predicted adolescents trust parents turn led later trust peers later trust politicians however maternal paternal warmth predicted trust politicians mediation personal belief world findings highlighted although parents important development adolescents trust mediating pathways differ depending types relationships involved
diagnosis aids south africa followed rapid rise number people living virus dying aids related illnesses report statistics south africa indicated million south africans infected hiv aids highest rate world despite emergence effective drugs mid medical treatment remained unavailable south africa particularly public hospitals prompted civil society groups establish platforms discuss health policy change south africa prominent among treatment action campaign tac formed aimed advocate improved hiv aids health service delivery efforts succeeded shaping current hiv aids policy various initiatives use constitutional law legal action profiteering drug companies paper examines role civil society particularly tac engagement state health policy making subsequent implementation health policy hiv aids post apartheid south africa
diagnostic evaluation treatment children cranial nerve palsies markedly different adults genetic traumatic inflammatory compressive etiologies common unlike adults vascular etiologies rare treatment entails addressing factors amblyopia fusion manuscript outline etiologies diagnostic work treatment cranial nerve palsies children
different shapes surface tension isotherms consistent butler ideal model planar surface phase binary liquid mixtures comprehensively worked first time using ratio pure constituent molar surface areas parameter named surface factor depends pure constituent properties butler equation expressed solved function two independent parameters geometrical features plots surface tension mole fraction component lower surface tension established every possible combination two parameters three main shape types found namely concave positive curvature concave passing inflection point followed concave concave negative curvature range parameter values leading shape type obtained shown graphically demonstrated butler ideal model excludes eventuality system presenting shape initial positive curvature inflection point continuing negative curvature shapes appear mirror image representation surface pressure mole fraction six organic organic systems including two ionic liquid solutions taken literature examined shown actual gibbs adsorption isotherm shapes arise sum ideal surface tension deviations excess surface tensions latter related equilibrium surface bulk ratio activity coefficients also shown ratio larger component greatest molar surface area comparison surface bulk activity coefficients chemical composition interesting insights surface phase drawn
digital llrf controller based embedded microcontroller booster dubna superconducting accelerator complex nica presented allows setting frequency accordance magnetic field value mhz range inaccuracy novel method frequency calculation based derivative proposed specialized tester module allows tuning checking system comissioning operation
disjunctive normal form conjunctive normal form boolean functions important construct logic formulas classical logic system shannon expansion symbolic computation tree logic generalized prove normal form boolean functions valued lukasiewicz logic system expansion valued mcnaughton functions induced logic formulas studied quasi disjunctive normal form quasi conjunctive normal form ary valued mcnaughton functions given
distance genitals anus anogenital distance reflects androgen concentration prenatal development mammals use anogenital distance human studies still limited quality consistency measurements important methodological issue aim study assess feasibility reproducibility adult male anogenital distance measurements two different methods men attending outpatient clinic university hospital underwent andrological examination completed brief questionnaire two variants anogenital distance anus posterior base scrotum agd cephalad insertion penis agd two methods lithotomy frog legged position assessed men within coefficient variations intra class correlation coefficients two way repeated measures analysis variance scatter bland altman plots calculated two methods produced similar values agd different estimates agd nonetheless overall agreement icc acceptable measures therefore methods internally consistent adequate epidemiological studies may used depending available medical resources clinical setting populations
dopamine receptor dopamine transporter investigated role attention deficit hyperactivity disorder adhd children reports genetic association adhd shown mixed results aim study evaluate association variable number tandem repeats vntrs drd dat genes adhd children pilot case control study clinically confirmed adhd cases age gender matched healthy controls conducted tertiary care centre mumbai variable number tandem repeats drd exon dat intron utr genotyped pcr age several allele repeats genes observed screened subjects statistical significance observed genotype dat utr vntr cases controls
dorsomedial prefrontal cortex dmpfc part mentalizing network set brain regions consistently engaged inferring mental states however precise function network remains unclear recently proposed dmpfc involved high level abstract categorical identification construction social non social stimuli referred high construal based observation greater activation dmpfc shared high construal social condition trait inference based visually presented behavior high construal non social condition categorization visually presented objects matched low construal conditions visual description pictures however dmpfc activation related task contexts requiring responses based self guided generation mental content decisions compared responses directly determined experimental context free rule governed choice previously reported dmpfc activity may reflect differences task constraint extent task context guided process confounded construal manipulation therefore present study manipulated construal level constraint independently participants underwent functional magnetic resonance imaging fmri participants visually described low level construal categorized high level construal pictures objects orthogonal description categorization task performed either one object low constraint two objects simultaneously high constraint limiting number possible responses statistical analysis revealed common greater activation high construal conditions high low constraint low construal counterparts replicating influence construal level dmpfc activation greater involvement high low construal influence constraint line previous proposals earlier work suggest dmpfc involved high construal abstraction across different domains
dual active bridge dab converter widely used distributed power systems energy storage devices however inherent nonlinearity dab converter cause serious stability problem paper dynamics digital controlled dab converter output voltage closed loop control studied firstly accurately study nonlinear dynamics stability dab converter full discrete time model dab converter established model considers esr output capacitor also considers digital control delay sample hold process using model stability dab converter versus parameter proportional controller analyzed stability boundary accurately predicted paper also points esr output capacitor bring great effect stability system finally simulation experimental results verify theoretical analysis
dynamic economic dispatch problem high dimensional complex constrained optimization problem determines optimal generation number generating units minimizing fuel cost last decades number solution approaches including evolutionary algorithms developed solve problem however performance evolutionary algorithms highly dependent number factors control parameters diversity population constraint handling procedure used paper self adaptive differential evolution real coded genetic algorithm proposed solve dynamic dispatch problem algorithm design new heuristic technique introduced guide infeasible solutions towards feasible space moreover constraint handling mechanism dynamic relaxation equality constraints diversity mechanism applied improve performance algorithms effectiveness proposed approaches demonstrated number dynamic economic dispatch problems cycle simulation results compared state art algorithms reveals proposed method merit terms solution quality reliability
economic risk construction stage mining project results uncertainty duration capital expenditure block caving mining projects characterised long lead time production often longer years high pre production capital expenditure resulting large pre production development requirements result size performance mine development system parameters bearing economic risk construction stage block caving projects study summarises results research aiming develop management tool real time face allocation equipment operation performance modelling tool combines stochastic discrete event simulation des programme evaluation review technique optimise size performance mine development system thus minimising duration pre production development highest risk parameter block cave projects furthermore model ample application potential mining operations tool assist management decisions short term planning equipment dispatching system model validated application chuquicamata underground mining project chile
education system recently undergone profound transformation due bologna process meant change way organization presentation teaching fitting european higher education area ehea new system lectures opened new tools promote quality improvement teaching learning process better use theory practice lectures may achieved proper organization presentation theoretical practical subject contents regard continuous improvement kaizen techniques associated manufacturing engineering business management may help one techniques known used establish maintain quality environment organization useful field education practitioners consider technique valuable improving physical environment improving thinking processes well work deals viability analysis implementation practice teaching learning process technique implemented ehea may summarized continuous application three elements classification organization clarity subject contents first necessary classification contents focus considered essential next ordered link coherently finally contents presented clearly attain greater understanding therefore hoped work serve explore technique applied teaching learning fields
effect cathode airflow variation dynamics fuel cell gas turbine hybrid system evaluated using cyber physical emulator coupling cathode airflow parameters turbine speed pressure analyzed comparing results fixed variable speed particular attention focused fuel cell temperatures gradients cathode airflow generally employed thermal management stack varied manipulating cold air bypass significant difference observed two cases terms turbine inlet exhaust gas cathode inlet average cell temperatures turbine speed held constant change cathode airflow resulted strong variation cathode inlet temperature average cell temperature significantly affected opposite behavior observed variable speed system dynamics analyzed detail order explain difference open loop response analyzed work essential role system identification however significant difference observed fixed variable speed cases high coupling turbine speed cathode airflow results give helpful insight system dynamics control requirements cold air valve bypass position also showed strong effect surge margin pressure dynamics cases
effect cooling water discharge skawina coal fired power station quality skawinka river water presented paper hydrochemical research river cooling water conducted water analyses sampled river measurement points cooling water discharge power plant dates cooling water samples collected discharge channel selected physicochemical indices assessed comprised temperature total suspended solids dissolved oxygen degree oxygen saturation electrolytic conductivity total dissolved substances analyses revealed cooling water discharge power station caused increase electrolytic conductivity concentrations dissolved substances chlorides skawinka water level exceeding border values waters purity class affected worsening chemical state river good good moreover cooling water discharge raised water temperature decreased dissolved oxygen content skawinka river water therefore worsening cyprinid fish habitat condition statistical analysis showed discharge statistically significantly increased concentrations analysed salinity indices nitrite nitrogen skawinka water however result cooling water pollution power generating technology applied power station effect cooling power station appliances polluted water taken vistula river use drained skawinka
effect greater trochanteric pain syndrome gtps gluteus medius gmed minimus gmin activation post menopausal women unknown aim study compare segmental muscle activation variability gmed gmin tensor fascia latae tfl gait postmenopausal women without gtps intramuscular electrodes inserted segments gmin gmed surface electrode placed tfl ten control participants gtps completed six walking trials peak amplitude average amplitude time peak phase gait cycle toe total stance swing compared groups using independent tests effect size calculations variability muscle activation calculated using mean coefficient variation reversal anterior gmin electromyographic burst pattern greater average muscle activity found gtps group compared controls anterior gmin anterior middle gmed posterior gmin gmed significant differences identified tfl overall study found increased segmental gluteal muscle activation decreased hip abduction strength reduced variability muscle activation post menopausal women gtps compared controls elsevier ltd rights reserved
effect high pulsed magnetic field different magnetic induced intensity microstructure mechanical performance solid titanium alloy investigated microstructure morphology characterized metallographic microscope scanning electronic microscopy transmission electronic microscopy results show magnetic induced phase transformation beta alpha volume fraction alpha phase increased meanwhile compared original sample dislocation density times result magneto plasticity effect however dislocation density always increase due dislocation pile effect mechanical properties tests show strength materials enhanced increase within certain scope strength elongation processed alloy exhibit obvious changes maximum strength reaches mpa ascribes dislocation strengthening enhanced compared original sample noted strength toughness improved simultaneously attributed dislocation strengthening also amount distribution morphology phase elsevier rights reserved
effect rapid thermal annealing oxide charge distribution hfo sio metal oxide semiconductor structures studied using technology computer aided design tcad simulations experiments simulated electrical characteristics compared experimentally obtained data interface traps found nonuniform nature laterally distributed following gaussian profile distribution interface trap charges arises spatial electric field variation oxide film upon gate bias application interface trap density found decrease increase annealing temperature observed higher annealing temperature fixed oxide charge density increases due interfacial silicate formation
effect sand grain shape size mechanical behavior geotextile reinforced sands investigated present research based results triaxial compression tests six clean uniform sands differing grain shape subangular rounded grains grain size well one non woven three woven geotextiles without apertures used experimental investigation triaxial compression tests conducted specimens diameter height consisting dry dense sands reinforced horizontal geotextile disks geotextile reinforced sands present higher strength axial strain failure unreinforced sands strength reinforced sands increases decreasing sand grain size increasing number geotextile layers affected grain shape sand since observed reinforced sands subangular grains attain higher strength values reinforced sands rounded grains triaxial compression tests yielded bilinear failure envelopes geotextile reinforced sands
effect single walled carbon nanotubes swcnts multi walled carbon nanotubes mwcnts addition phase formation superconducting properties gdbacuo delta phase studied therefore composite superconductor samples type cnts gdbacuo delta synthesized standard solid state reaction technique samples characterized using ray powder diffraction xrd scanning electron microscope sem transmission electron microscope tem results xrd show enhancement phase formation swcnts mwcnts respectively sem tem reveal cnts form electrical network resulting well connected superconducting grains electrical properties prepared samples examined electric resistivity measurements results reinforce xrd sem tem consequently improve addition percentage increases swcnts mwcnts respectively
effect spatial variations mean radiant temperature occupancy hvac energy occupant thermal comfort studied operi plan office space multiple ahus predictive control method proposed arrives optimum temperature set point vector solving optimization problem minimizes hvac energy consumption subject acceptable thermal comfort adequate outside air intake optimum temperature set point vector used pid controller modulates ahu fan speed proposed control evaluated occupancy traces observed open plan space compared static set points based pid control strategies normally pid control operates dead band around static set point ahu fan speed adjusted return air temperature outside dead band proposed control dynamic set point hence ahu speeds adjusted much finer time steps normal control occupancy traces classified densely sparsely occupied days across days proposed control achieves average additional savings pid control assumes uniform spatial occupancy distribution ahu control pid based strategy uses actual spatial occupancy information elsevier rights reserved
effective properties well local fields heterogenous magneto electro elastic mee materials coated fibers investigated using variational asymptotic homogenization method starting total electromagnetic enthalpy heterogenous continuum multiphysics micromechanics model formulated constrained minimization problem taking advantage face size microstructure small compared macroscopic size material treat general microstructure smart material engineering applications new model implemented using finite element technique comparison finite element analysis fea results demonstrates application accuracy proposed model prediction multiphysical behavior effects coating different thickness stiffness stress concentration factor effective mee properties discussed lot interesting mee interaction phenomena revealed useful estimate optimize performance mee composites elsevier ltd rights reserved
effectiveness vasomotor symptoms sleep disorders plus long term safety nutraceutical combination agnus castus magnolia extracts combined soy isoflavones lactobacilli assessed postmenopausal women controlled study carried menopausal women comparing nutraceutical combination esp group formulation containing isoflavones alone group dosage recommended kuppermann index pittsburgh sleep quality index psqi short form determined baseline three six months endometrial thickness mammary density liver function evaluated baseline months one hundred eighty women enrolled study esp group group end treatment mammary density endometrial thickness hepatic function show substantial differences groups kuppermann index particularly tendency hot flashes progressively significantly decreased frequency severity esp versus treatment time significant increase sleep quality psychophysical wellness parameters observed esp versus groups adverse events observed agnus castus magnolia combined lactobacilli effectively safely used symptomatic postmenopausal women mainly quality sleep disturbing complaint endometrium mammary glands liver function unaffected months treatment
effectiveness single layer geocell reinforced soil investigated geotechnical applications researchers limited height commercially produced geocell major obstacle achieve uniform suitable density inside cells leads investigate performance multi layered geocell reinforced soil improving behaviour soil paper series triaxial compression tests carried natural soil without geocell layers layers configuration two four horizontal geocell reinforcing layers triaxial test sample influences number geocell layers confining pressure studied described based test results observed strength soil improved significantly geocell layers also results indicate mass geocell material used reinforced soil samples four layers geocell reinforcement behaves effectively obtained two layers geocell reinforcement improve stress strain behavior apparent cohesive strength induced geocell reinforcement increases significantly increase geocell layers two four whereas friction angle soil samples affect geocell reinforcement use improvement strength response due inclusion layers geocell advantageously used bearing capacity improvement settlement reduction design shallow foundations pavement system
effectiveness treatment individuals diagnosed antisocial personality disorder aspd questioned debated years individuals aspd considerably overrepresented criminal justice system ability treatment reduce recidivism prominent concern present meta analysis identified six unique controlled uncontrolled treatment outcome studies investigating effectiveness treatment reducing general recidivism individuals aspd results controlled studies indicated significant differences recidivism rates individuals aspd treatment treatment usual however direction odds ratios suggested lower recidivism treatment groups results uncontrolled studies suggested equal effectiveness treatment comparing individuals without aspd however effects may attributable treatment question interpretation findings generalizability general offender treatment literature individuals aspd discussed
effects different catchment types storage conditions pseudomonas aeruginosa harvested rainwater wet dry seasons investigated horizontal roof intercepted outlet point vertical surface bottom quality variation inside storage tanks different rainwater harvesting rwh systems also monitored numbers aeruginosa varied colony forming units cfu dry season cfu wet season relatively good quality harvested rainwater observed dry season horizontal vertical quality variation aeruginosa revealed best quality supply point number aeruginosa highest cfu wet dry seasons respectively rainwater harvested mountain catchment lowest cfu dry wet seasons respectively numbers seen concrete roof catchment dark covered storage conditions resulting low rainwater temperatures showed better microbial quality rainwater uncovered open storage conditions exposed light study suggests improvement quality harvested rainwater possible appropriate tank designs maintenance catchment surfaces proper storage conditions considered rwh systems
effects globalization globalization responsibilities due globalization global international criminal responsibility perpetrators crime follow states one international actors also exempt issue criminal responsibility rulers communication sensitivity governance principles coupled lot complexity according principle necessity anticipate criminal responsibility states prevent avoid lot international crimes nature support assistance states international dimension establish international order security line process globalization inevitable however removal article draft international responsibility state approved international law commission represents important source international criminal responsibility government doubt government criminal liability stressed elimination need prejudice existence numerous international documents procedures expression fact many behaviors violate rules universal acceptance international community done governments civil responsibility governments violate rules universal important accordance principles justice international law need maintain international peace order international community makes states vacuum exploited order resolve ambiguities criminal responsibility state use existing capacity international community including security council build infrastructure necessary arrangements progressive development institutions international criminal court done
effects jump training bone structure ovariectomy induced osteopenia rats investigated jumping exercise induced favorable changes bone mineral density bone mechanical properties bone formation resorption markers exercise effective prevent bone loss ovariectomy even osteopenia already established present study investigated effects jump training bone structure ovariectomy induced osteopenia week old wistar rats forty rats prevention program randomly allocated one four equal groups sham operated sedentary sham sedp ovariectomized ovx sedentary ovx sedp sham operated exercised sham exp ovx exercised ovx exp sham exp ovx exp animals began training days surgery another rats treatment program randomly allocated another four groups sham operated sedentary sham sedt ovx sedentary ovx sedt sham operated exercised sham ext ovx exercised ovx ext sham ext ovx ext animals began training days surgery rats exercised groups jumped times day days week height weeks end experimental period serum osteocalcin follicle stimulating hormone fsh dosage dual ray absorptiometry dxa histomorphometry biomechanical tests analyzed ovx groups showed higher values fsh body weight dxa showed jump training significantly increased bone mineral density femur fifth lumbar vertebra stiffness left femur fifth lumbar vertebra exercised groups greater sedentary groups ovariectomy induced significant difference bone volume percent trabecular separation micrometer trabecular number per millimeter compared sham operation jump training ovx group induced significant differences decreased osteoblast number per bone perimeter compared ovx nontraining prevention groups osteocalcin dosage showed higher values exercised groups jumping exercise induced favorable changes bone mineral density bone mechanical properties bone formation resorption markers jump training effective prevent bone loss ovariectomy even osteopenia already established
effects putrescine put treatment anthocyanin concentrations bioactive compounds two blood orange moro tarocco cultivars cold storage investigated put applied fruit vacuum infiltration kpa min stored degrees days plus simulated shelf life days degrees put treatment maintained higher fruit firmness reduced weight loss storage anthocyanin total phenolic content tpc ascorbic acid content antioxidant activity also higher treated fruit control storage titratable acidity highest treated fruit soluble solids concentration ssc ssc ratios highest untreated fruit overall quality blood oranges maintained put treatment cold storage elsevier ltd rights reserved
effects strength hardness ductility series well annealed palladium silver alloys due hydrogen exposure investigated various temperatures results indicate temperature hydrogen exposure occurs significant effect degree mechanical properties altered relatively low temperatures found strength hardness alloy increased ductility decreased upon hydrogen exposure alloys changes observed magnitude changes found diminish silver content increases certain hydrogen exposure temperature value decreases increasing silver content strength hardness ductility alloy show significant changes result hydrogen exposure american society civil engineers
efficacy antiviral treatment chronic hepatitis virus hcv infection determined measuring hcv rna specific time points throughout therapy using highly sensitive accurate hcv rna assays study compared performances two recently developed real time pcr hcv rna assays cobas hcv use cobas systems cobas hcv cobas hcv use cobas system cobas hcv two established assays cobas ampliprep cobas taqman hcv quantitative test version cap ctm cobas taqman hcv test version use high pure system hps ctm limits detection lods linearity lower concentrations assessed cobas hcv cobas hcv using standard traceable panels representing hcv genotypes pairwise assay comparisons also performed using clinical samples representing hcv results cobas hcv cobas hcv linear low hcv rna concentrations log difference expected observed results lods respectively new assays showed excellent agreement results cap ctm hps ctm samples quantifiable viral loads concordances using million cutoff high among four assays conclusion cobas hcv cobas hcv tests sensitive linear correlate well established roche assays used clinical practice
efficacy phenol transport aqueous phase peat soil assessment attenuation capacity migratory phenol subsurface water pollution investigated application multiple linear regression mlr artificial neural network ann models batch kinetics study performed revealed freundlich isotherm model fits reasonably well experimental results maximum value phenol removal efficiency achieved soil initial concentration phenol equilibration time sum total laboratory batch adsorption tests conducted results applied mlr ann models influencing factors initial concentration mass soil contact time forth removal sorbate peat also investigated present research experimental results exhibit reasonable goodness fit higher coefficient determination lower root mean square error rmse mean absolute performance error mape previous models
efficacy therapeutic treatments autism spectrum disorder mainly associated treatment intensity terms weekly hours led mental health professionals explore use video games complement traditional treatments however major weaknesses found due poor game design failed fulfill therapeutic objectives properly engage children weaknesses typically characterized poor integration knowledge mental health experts children interests designers expertise starting necessity propose inclusive design approach develop therapeutic games method presents strategies integrate expertise clinicians contributions children experience designers set elicitation merging techniques goal method design games effective terms therapeutic objectives enjoyable children describe method present application design development kinect based game high functioning children asd called pico adventures game aims promoting social initiation young children autism findings first exploratory study children asd showed effectiveness game eliciting social initiation behaviors provides first validation method essential aspect game success use elements mechanics appealing children result identified effective design concepts paths research games children asd elsevier ltd rights reserved
efficiency benefits deriving staging evaporation process multiple pressure levels well known field gas steam natural gas combined cycles dual triple pressure bottoming cycles represent standard layouts similar development cycle architecture observed field organic rankine cycle systems orcs paper dual pressure layout compared single pressure one subcritical conditions utilization geothermal heat source range considering set working fluids wide enough take advantage features layouts paper proposes simple unambiguous design guidelines avoid unnecessary complexity dual pressure layout single pressure one already ensures highest power output taking advantage full potential conditions results show power output gains deriving dual pressure configuration particularly high lower geothermal fluid temperatures gradually diminish higher temperatures degrees selected fluids already obtain best thermal matching heat source single pressure configuration elsevier ltd rights reserved
efficient vibration control complex multibody systems important issue engineering design drawn substantial attention field multibody system dynamics control engineering paper combining transfer matrix method multibody systems modal space control active vibration control design method presented dynamic modeling vibration control design multibody systems state space equations terms generalized coordinates modal space obtained easily based independent modal space control method robust independent modal space controller presented active vibration control general linear multibody systems proposed method low memory requirements high computational efficiency additional advantages dynamic design real time control general multibody systems numerical simulation example vibration control multiple launch rocket system given validating method control performance american society civil engineers
election donald trump president earmarks new beginning american domestic foreign policies populist thinking unconventional approach caused great uncertainty recognizing challenges president trump may bring world general china relations particular chinese government core leadership president jinping firmly believes world general trend sustained progress remains committed track win win cooperation countries adopting reactive proactive attitudes toward great changes global arenas taking every precaution worst possible scenario better manage china relations critical juncture world development imperative countries adapt various new changes deepen mutual understanding diplomatic philosophy continue sharing dividends peace development two countries manage pass first rounds tests active conceptual matching pragmatic cooperation better position realize respective national agendas rejuvenation chinese nation making america great otherwise countries even whole world may fall devastating confrontation escalating conflicts
electrical response functionalized graphene nanoplatelets composite materials strain studied two different manufacturing methods proposed create electrical network work incorporation nanoplatelets epoxy matrix coating glass fabric sizing filled nanoplatelets types multiscale composite materials plane electrical conductivity similar showed exponential growth electrical resistance strain increases due distancing adjacent functionalized graphene nanoplatelets contact loss overlying ones sensitivity materials analyzed research using described procedures shown higher commercially available strain gauges proposed procedures self sensing structural composite material would facilitate structural health monitoring components difficult access emplacements offshore wind power farms although sensitivity multiscale composite materials considerably higher sensitivity metallic foils used strain gauges value reached functionalized graphene nanoplatelets coated fabrics nearly order magnitude superior result elucidated potential used smart fabrics monitor human movements bending fingers knees using proposed method smart fabric could immediately detect bending recover instantly fact permits precise monitoring time bending well degree bending
electrification agricultural vehicles often discussed several prototypes use electric machines traction drive known however design electric motor particular challenge special characteristics drive cycle agricultural tractor high torque low speed low torque high speed required results wide speed range represents particular challenge machine design paper describes possibilities realize wide speed range influence design electric machines
electrification sectors heating transportation represents challenge well opportunity distribution system operators one hand committed accommodate large numbers highly rated loads networks designed hand represent source flexibility used satisfy different technical commercial purposes paper introduces upgraded hierarchical structure aims serve platform activating controlling demand response low voltage networks way system operator playing role aggregator could trade flexible demand power markets also materialize energy agreements ensuring local network security reliability verify effectiveness extended method danish network considered results show possible fulfill energy commitments energy markets regulation power market respecting proper network operation however activation flexibility offered might limited depending network characteristics season year
electrode distance variance capacitance style pressure sensor talked change rate pressure treated judging basis whether fault existed make bridge output signal sensor output signal one detection signal also make operational amplifier output signal another detection signal expressions element drift failure changeless input signal obtained change laws analyzed basis works verified different elements failure distinguished solved works fault location fault evaluation realized simulation tells value fault diagnosis results relatively close true value fault
elongation styles stigma silks maize zea mays flowers rapid mmh occurs short period plays pivotal role reproductive success adverse environments silk elongation rate measured using displacement transducers plants eight genotypes eight experiments varying evaporative demand soil water status measured time courses revealed silk elongation rate closely followed changes soil water status evaporative demand day night alternations similar leaves day night alternations steeper high low plant transpiration rate manipulated via evaporative demand covering part leaf area half times changes silk elongation rate upon changes evaporative demand soil water status min similar leaves sensitivity silk elongation rate xylem water potential genetically linked leaf elongation rate lines greatly differed sensitivities results consistent common hydraulic control expansive growth vegetative reproductive structures upon changes environmental conditions via close connection xylem water potential important implications breeding modelling phenotyping
embryonic development synapses rostral nucleus solitary tract rnst investigated rat determine synapses begin function using brain slice preparation studied appearance synaptic receptors second order rnst neurons investigated development postsynaptic responses elicited afferent nerve stimulation prenatal excitatory inhibitory synaptic responses recorded early glutamatergic gabaergic postsynaptic responses detected early nmda ampa receptors contributed glutamatergic postsynaptic responses gabaergic postsynaptic responses resulted primarily activation gaba receptors however functional gaba receptors also demonstrated glycinergic postsynaptic response found although functional glycine receptors demonstrated solitary tract stimulation evoked epscs first detected eliminated glutamate receptor antagonists evoked ipsps also detected eliminated gabaa receptor antagonist thus considerable prenatal development rnst synaptic connections occurs ensure postnatal function central taste processing circuits elsevier rights reserved
endogenous oxytocin system plays vital role facilitating parturition lactation social interaction humans mammals also impacts number important endocrine immune neurotransmitter systems well regulated oxytocin system proposed increase resilience therefore reduce likelihood individual developing mental illness substance dependence review discusses adverse external influences modulate oxytocin receptor protein levels impact substance use mental health paper highlights impact adversity poor maternal care parental substance use child abuse neglect review clinical preclinical data impact adversity basis time exposure infancy early childhood adolescence adulthood older age previous research suggests dysregulation endogenous oxytocin system may implicated determining susceptibility stress anxiety addiction mental health conditions impact external influence seems strongest specific time periods system shows experience based development natural fluctuations oxytocin levels interventions target oxytocin system soon exposure adversity may prove protective copyright wolters kluwer health inc rights reserved
enhancement depletions total electron content tec storm days quiet day values analysed different seasons solar activity conditions palehua low latitude station period considering dependence enhancement storm time tec positive storms solar radio flux positive correlation observed winter equinox negative storms correlation depletion storm time tec solar radio flux positive equinox dependency observed summer intensity storm found negatively correlated enhancement storm time tec equinox positive storms dependency shown winter negative storms depletion storm time tec shows dependency equinox shows positive correlation summer considering dependence enhancement tec max positive correlation observed winter equinox positive storms negative storms correlation depletion storm time tec max found positive summer equinox similar correlation study carried time delay tau occurrence maximum enhancement depletion tec maximum minimum percentage probability range delta tec also analysed considering data seasonally elsevier ltd rights reserved
environment parents socialize children eating physical activity screen related behaviors changed widely faulted obesity epidemic phenomenological study examined intentions reflections strategies purposefully selected group mothers self reported successful socializing children obesity related behaviors determined scoring highly family nutrition physical activity screening tool mothers described power modeling positive obesity related behaviors creating culture promoted activity sedentariness focusing establishing positive behaviors home framing choices opportunities support child autonomy mothers believed preparing children resist threats obesigenic environment voices mothers present strengths perspective provide narrative complements research representative risk populations findings may inform obesity prevention intervention programs well parenting education curricula
eph family receptor tyrosine kinases serves key modulators various cellular functions including inflammation hypertrophy fibrosis recent analyses revealed member eph family epha plays pivotal role regulating insulin metabolism kidney injury however importance epha diabetic nephropathy recognized established diabetic nephropathy mouse model using high fat diet streptozotocin stz injection recombinant adeno associated virus type aav overexpressing epha negative control injected locally kidney metabolite testing histopathological analyses kidney fibrosis pancreatic islet function signaling pathways evaluated study showed hyperglycemia insulin resistance renal fibrosis accompanied deterioration kidney function diabetic mice expression epha kidney attenuated renal fibrosis improved kidney function affect systemic glucose metabolism pancreatic islet function furthermore overexpression epha decreased phosphorylation erk jnk mypt substrate rho kinase overexpression epha therapeutically targeted inhibit diabetic renal fibrosis suggests epha epha receptor axis may novel therapy target diabetic nephropathy mechanistically overexpression epha could inhibit mapk rho pathway diabetic kidneys elsevier inc rights reserved
equivalent force control efc method developed real time hybrid testing replace numerical iteration implicit integration force feedback control loop control loop efc method also compensate time delay real time hybrid testing however delay compensation effect efc influenced factors noises measured displacement paper discusses influence measurement noises real time hybrid testing efc kalman filter proposed filter noises measured actuator displacement improved performance higher proportional gain pid controller improves effect time delay compensation efc method allowed without losing stability incorporating kalman filter series real time hybrid tests conducted results validated efc method kalman filter effectively compensate time delay copyright john wiley sons ltd
esophagus stomach host population bacteria differs health disease helicobacter pylori uniquely colonizes gastric mucosa increasing number bacteria isolated gastric juice gastric mucosa including lactobacillus presence pylori alters populations gastric bacteria marked reduction diversity alterations intragastric acidity may cause consequence changes microbial populations stomach esophageal inflammation associated altered microbiota gastroesophageal reflux disease barrett esophagus eosinophilic esophagitis cancer
estimates global incidence prevalence non alcoholic fatty liver disease nafld worrisome due parallel burden obesity metabolic complications indeed excess adiposity insulin resistance represent two major risk factors nafld interestingly last years growing body evidence tended support novel mechanistic perspective liver center complex interplay involving organs systems adipose tissue glucose homeostasis bone skeletal muscle fat free tissues appeared independently associated nafld several cross sectional studies deterioration bone mineral density lean body mass leading osteoporosis sarcopenia respectively age related processes prevalence nafld also increases age beyond physiological aging three conditions share common underlying mechanisms elucidations could paramount importance design effective treatment strategies management nafld review provide overview epidemiological data well potential contributors connections nafld bone skeletal muscle
estimation material properties important scene understanding many applications vision robotics structural engineering paper connects fundamentals vibration mechanics computer vision techniques order infer material properties small often imperceptible motions video objects tend vibrate set preferred modes frequencies modes depend structure material properties object show extracting frequencies video vibrating object often make inferences object material properties demonstrate approach estimating material properties variety objects observing motion high speed regular frame rate video
estimation nutrient content plants considerably important agricultural practices especially enabling application precision farming plethora methods used estimate nitrogen amount plants including utilization computer vision however image based nitrogen estimation methods conducted controlled environments methods practical time consuming require many equipment therefore crucial need develop method estimate nitrogen content plants based leaves images captured field challenging task since intensity sunlight always changing leads inconsistent image capturing problem paper develop low cost simple accurate approach image based nitrogen amount estimation plant images captured directly sunlight using conventional digital camera subject variation lighting conditions propose color constancy method using neural networks fusion genetic algorithm normalize various plant images due different sunlight intensities macbeth color checker utilized reference normalize color images also develop combination neural networks using committee machine estimate nitrogen content wheat leaves twelve statistical rgb color features used input parameters nutrient estimation obtained result shows considerable better performance conventional gray world scale max approaches well linear model single neural network methods finally show nutrient estimation approach superior commonly used soil plant analysis development meter based prediction
estimation theoretical strength materials important order assess potential improvements processing design structures especially increased interests nanostructured materials estimates based knowledge inexact potential energy functions fractal geometry presents mathematical approach understanding fracture materials length scales fractal dimension quantitative characterization tortuosity fracture surface directly related toughness material fractal geometry provides framework bond rupture described series bond reconfigurations article shows fractal geometry use framework estimate theoretical strength materials based crack tip geometry generated fracture surface without assumption shape type potential energy function estimates commonly quoted values elsevier rights reserved
european automotive quality sector skill alliance aqua establishing practice oriented education training program modern automotive engineering challenges since context recent activity transfer certified industry training program integrated automotive quality engineering management higher education article introduces practical example used new curriculum explain functional safety dimension integrated automotive quality since students highly interested electric hybrid vehicles technologies example motor control drivetrain chosen case study
evaluation technique radiation degradation temperature dependences operational amplifier input bias currents developed technique improve accuracy prediction radiation hardness operational amplifiers full operation temperature range
event index project consists development deployment complete catalogue events experiments large amounts data atlas experiment lhc accelerator cern data stored eventindex produced production jobs run cern grid every permanent output file snippet information containing file unique identifier relevant attributes event sent central catalogue estimated insertion rate lhc run file records containing similar khz event records contribution describes system design initial performance tests full data collection cataloguing chain project evolution towards full deployment operation end
ever increasing need cost efficient high density power transmission brought fore applied superconductivity alternative worth investigating especially high temperature superconducting hts cables emerge promising solution bulk power transmission use near future expected increased hts cables special characteristic varying performance different critical conditions especially different operating temperatures therefore detailed thermal analysis hts cables representing thermodynamics heat transfer varying length time significant importance analytical mathematical formulation presented paper solves heat transfer equations two dimensional axisymmetric cable model identifies temperature distribution length time analysis conducted bipolar cable suggested electric power research institute long distance hts transmission steady state transient scenarios examined
evolution increasing commoditization home building automation systems hbas contributing widespread adoption however effort must still made render usable intelligent highly adaptive able fulfill users needs distinct users interact system intentions likely different often resulting conflicting situations system ought recognize possible resolve automatically however conflict detection resolution hbas yet fully understood work aims investigating conflict ambient intelligence systems namely supported hbas main contribution systematization review existing literature concerning conflict detection resolution systems
excellent features bearing vibration signal helpful obtain accurate diagnosis results failure bearing study feature extraction method bearing vibration signal based wavelet packet transform phase space reconstruction singular value decomposition wps presented improve traditional feature extraction method bearing vibration signal based wavelet packet transform singular value decomposition proposed feature extraction method singular value decomposition performed phase space reconstruction signal wavelet packet coefficient reconstructed signal bearing vibration signal dynamic characteristics certain frequency range reflected phase space reconstruction wavelet packet coefficients reconstructed signals bearing vibration signal support vector machine svm machine learning method based structural risk minimization principle svm classifier solve classification problems small training samples high dimensions nonlinearity thus svm model bearing established features bearing vibration signal based wavelet packet transform phase space reconstruction singular value decomposition study experimental results show feature extraction method bearing vibration signal based wavelet packet transform phase space reconstruction singular value decomposition better feature extraction method bearing vibration signal based wavelet packet transform singular value decomposition svm established features bearing vibration signal based wavelet packet transform phase space reconstruction singular value decomposition wps svm stronger fault diagnosis ability bearing svm established features bearing vibration signal based wavelet packet transform singular value decomposition svm
exemplar breakpoint distance problem motivated finding conserved sets genes two genomes asks find respective exemplars two genomes minimize breakpoint distance one genome repeated gene called trivial genome genes repeating twice referred exemplar breakpoint distance problem ebd short little done algorithm design problem article propose parameter describe maximum physical span two copies gene genome based design fixed parameter algorithm ebd using dynamic programming approach algorithm take time space solve ebd instance two genomes genes second genome two copies gene spanning copies genes algorithm also used compute maximum adjacencies two genomes algorithm implemented simulations randomly generated data verified effectiveness algorithm software package available authors
existence spou trmd spout rna methyltransferase superfamily first predicted bioinformatics spou previous name trmh catalyzes methylation ribose trna trmd catalyzes formation methylguanosine position trna although spou trmh trmd originally considered unrelated bioinformatics study suggested might share common evolution origin form single superfamily common feature spout rna methyltransferases formation deep trefoil knot catalytic domain past decade spout rna methyltransferase superfamily grown furthermore knowledge concerning functions modified nucleosides trna also increased enzymes potential targets design anti bacterial drugs humans defects genes may related carcinogenesis review recent findings trna methyltransferases spout fold methylated nucleosides trna including classification trna methyltransferases spout fold knot structures domain arrangements subunit structures reaction mechanisms trna recognition mechanisms functions modified nucleosides synthesized superfamily summarized lastly future perspective studies trna modification enzymes considered
existing railway wagon flow forecast method meet demand actual railway transport organization old system embodied slow computing speed low accuracy railway wagon flow forecast system based hadoop hazelcast designed improve accuracy forecast shorten calculation time expand scale calculation using hadoop framework analyze history wagon flow data get wagon flow data feature using hazelcast architecture solve bottlenecks new forecast system integrates scattered memory memory computing cluster compute time window parallel results show method system greatly improve forecast accuracy speed
experimental method used predict solubility parameter brazilian crude oils takes account critical solubility parameter assumption work experimental ratifications assumption found crude oils nonpolar asphaltene mixtures important matter since oil compatibility estimated assumption models based regular solution flory huggins theories used estimate solubility data least soluble asphaltenes thereby observed employment kikic modification flory huggins combinatorial term plus replacement traditional hildebrand solubility parameter hansen solubility parameter energetic term greatly improved performance models led best correlation even polar associative solvents addition impact asphaltene blending brazilian oil stability evaluated two asphaltene fractions sequentially extracted results point asphaltene subfractionation taken account solubility modeling results critical solubility parameter brazilian oils mpa proposed used universal input parameter experimental methodology predicting solubility parameter crude oils based asphaltene stability predicted solubility parameter fully compatible calculations three empirical models also correlate property experimental data crude oils elsevier ltd rights reserved
extant literature shows third person perceptions depend subjective knowledge people think know greater perceived communication effects others study extends previous research third person perceptions investigating persuasion knowledge influence third person perceptions related behavior advertising context analyzing whether regulatory competence government moderates effect results two studies experiment survey show subjective knowledge persuasion attempts advertising increases third person perceptions turn reduce consumers willingness recommend product effect moderated perceived regulatory competence government influence persuasion knowledge third person perceptions becomes stronger weaker regulatory competence perceived furthermore influence persuasion knowledge third person perceptions due overestimated influences others findings provide implications advertisers public policy makers
extent non alpha beta versus alpha beta nachrs contribute behavioral effects varenicline nachr agonists unclear purpose study characterize discriminative stimulus effects varenicline nicotine using various nachr agonists antagonists elucidate possible non alpha beta nachr mechanisms separate groups male cbl mice trained discriminate varenicline nicotine test drugs included mecamylamine nachr agonists epibatidine nicotine cytisine varenicline rti beta containing nachr antagonist dihydro beta erythroidine beta alpha nachr agonist pnu alpha antagonist methyllycaconitine mla alpha beta antagonist methoxycoronaridine non nachr drugs midazolam cocaine nicotine trained mice maximum nicotine appropriate responding nicotine epibatidine varenicline cytisine less rti pnu midazolam cocaine varenicline trained mice maximum varenicline appropriate responding varenicline epibatidine cytisine rti cocaine less nicotine pnu midazolam drugs studied doses abolished operant responding mecamylamine antagonized discriminative stimulus effects rate decreasing effects nicotine varenicline beta antagonized discriminative stimulus rate decreasing effects nicotine varenicline either nicotine varenicline discrimination assays discriminative stimulus rate decreasing effects epibatidine antagonized beta regardless training drug results suggest alpha beta nachrs differentially mediate discriminative stimulus effects nicotine varenicline suggest varenicline substantial non alpha beta nachr activity
fact technology changed lives human beings denied drastically reduced effort needed perform particular task increased productivity efficiency computers especially playing important role almost fields today world used store large amount data almost sectors business industrial sectors personal lives research areas science technology uses computers solve complex critical problems information important requirement individual era quick growing huge data become increasingly illogical analyse help traditional techniques relational databases new big data instruments architectures designs come existence give better support requirements organizations institutions analysing large data specifically elasticsearch full text java based search engine designed keeping cloud environment mind solves issues scalability search real time efficiency relational databases able address paper present experience elasticsearch open source apache lucene based full text search engine provides near real time search ability well restful api ease user field research
failure barlin dam taiwan china offers important case study evaluating concepts modeling rapid erosion channel recovery following intentional unplanned dam removals present modeling effort applied quasi uncoupled hydraulics sediment model netstars evaluate discretization parameterization influence thefitofbed elevationpredictions observations following dam failure analysis evaluated model sensitivity sediment transport function active layer thickness number stream tubes used define cross section results indicate model sensitive active layer thickness sediment transport function number stream tubes development dam removal models likely benefit varying active layer thickness time increased lateral discretization appear improve model fit steep rapidly changing river environment site conclude discussion differences identifying need general use quasi fully models dam removal failure analysis international research training centre erosion sedimentation world association sedimentation erosion research published elsevier rights reserved
fall one important research fields solitary elder healthcare home based internet things technology current studies mainly focus fall detection helps medical staffs bring fallen elder danger time however neither predicts fall provides effective protection fall article studies fall prediction based human biomechanics equilibrium body posture characteristics analyzing three dimensional skeleton joints data depth camera sensor kinect research includes building human bionic mass model using skeleton joints data kinect determining human balance state proposing fall prediction algorithm based recurrent neural networks unbalanced posture features evaluate model algorithm open database performance indicates fall prediction algorithm studying human biomechanics predict fall provide certain amount time elder injuring hitting floor work provides technical basis data analytics approach fall protection
fast sweeping method popular algorithm solving variety static hamilton jacobi equations fast sweeping algorithms parallel computing developed severely limited work present multilevel hybrid parallel algorithm combines desirable traits two distinct parallel methods fine coarse grained components algorithm take advantage heterogeneous computer architecture common high performance computing facilities present algorithm demonstrate effectiveness set example problems including optimal control dynamic games seismic wave propagation give results convergence parallel scaling show state art speedup values fast sweeping method elsevier inc rights reserved
fatigue strength high alloyed powder metallurgy tool steel two different inclusion size levels tempered different temperatures investigated series high cycle fatigue tests shown brittle inclusions large sizes prompted occurrence subsurface crack initiation reduction fatigue strength fracture toughness stress amplitude exerted significant influence fish eye size larger fish eye area would form sample higher fracture toughness subjected lower stress amplitude stress intensity factor inclusion found lie typical value threshold stress intensity factor mpa fracture toughness sample hardness hrc could estimated mean value stress intensity factor fish eye according fractographic evaluation critical inclusion size calculated linear fracture mechanics
federal highway administration long term bridge performance programme initiated international bridge study selecting steel stringer bridge benchmark structure structural health monitoring part programme authors studied application long gauge fibre bragg grating fbg sensors bridge paper aims illustrating fbg related state art technologies taking bridge test bed concept fbg sensor area sensing presented fibre optic sensors measure point strains local monitoring contrast developed fbg area sensor long gauge connected make sensor array distributed strain measuring spectral analyses macro strain time histories performed identify structural frequencies results compared estimated acceleration measurements neutral axis position girder investigated bridge estimated recorded macro strain time histories results compared static truck tests modal macro strain based damage index applied damage detection steel stringer bridge
field interstitial lung disease ild undergone significant evolution recent years increasing incidence complex ever expanding disease classification severe forms diseases lead progressive loss lung function respiratory failure eventually death despite notable advances progress challenged poor understanding pathological mechanisms patient heterogeneity including variable progression diagnostic pathway thus continually refined introduction tools transbronchial cryo lung biopsy move towards genetically aided precision medicine review focus approach patient ild diagnostic process
fifty shades trilogy james taken world storm become cultural phenomenon lack contraceptive use erotic fiction first pointed bloggers analysed article compared medical information james may praised sexualising condom use however protagonist makes poor choices terms hormonal contraception negligent use resulting unintended pregnancy resolved marital bliss motherhood interest possible message contraceptive use outcome fiction negligence birth control responsibility affirms ideology female sexuality sexual experimentation tolerated within context procreation affirmation motherhood subsequently cultural significance trilogy popularity tension sexual exploration birth control fertility explored globally popular fantasy published five decades introduction pill protagonist lack attention reliable birth control leads telling dichotomy combines adventurous exploration female sexuality affirmation nuclear family resumela trilogie des cinquante nuances james fait rage partout dans monde est devenue phenomene culturel non utilisation contraceptifs dans cette fiction erotique abord relevee par les blogueurs est analysee dans cet article comparee information medicale james peut etre saluee pour avoir sexualise usage preservatif revanche protagoniste fait mauvais choix matiere contraception hormonale montre negligente qui concerne son utilisation resulte une grossesse non desiree qui resout dans bonheur conjugal maternite qui est ici plus interessant que tout possible message concernant recours contraception est que consequence cette negligence relativement controle des naissances responsabilite assoit ideologie selon laquelle sexualite experimentation sexuelle feminines peuvent etre tolerees que dans contexte procreation affirmation maternite suite cette analyse sens culturel popularite trilogie tension cette derniere entre exploration sexuelle controle des naissances fertilite est examinee dans fantasme populaire mondial publie plus cinq decennies apres introduction pilule peu attention pretee par protagoniste des methodes fiables controle des naissances conduit une dichotomie eloquente qui combine exploration aventureuse sexualite feminine affirmation famille nucleaire resumendebido popularidad trilogia cincuenta sombras james conquistado mundo volviendose fenomeno cultural los blogueros fueron los primeros senalar poco uso que hace los anticonceptivos ficcion erotica practica que presente articulo analiza compara con informacion medica existente respecto aunque puede elogiarse james por haber sexualizado uso condones protagonista realiza malas elecciones respecto uso anticonceptivos hormonales descuidando mismo ello lugar embarazo intencionado que postre resuelto con felicidad conyugal maternidad mas alla posible mensaje cuanto uso anticonceptivos aspecto interesante este sentido tiene que ver con resultado pues negligencia cuestiones control natalidad responsabilidad mostrada esta obra ficcion termina reafirmando aquella ideologia que sexualidad femenina experimentacion sexual solo pueden ser toleradas contexto procreacion confirmacion maternidad asimismo articulo examina significacion cultural que implica popularidad esta trilogia asi como tension existente entre exploracion sexual control natalidad fertilidad esta fantasia popularidad mundial publicada mas cinco decadas introduccion pildora desparpajo protagonista respecto los anticonceptivos confiables genera una dicotomia reveladora que combina exploracion aventurera sexualidad femenina con reafirmacion familia nuclear
fine periodic growth patterns shell surfaces widely used studies ecology evolution scallops modern ray scanners digital cameras provide high resolution image data contain abundant information shell formation rate ontogenetic age life span shellfish organisms introduced novel multiscale image processing method based matched filters gaussian kernels partial differential equation pde multiscale hierarchical decomposition segment small tubular periodic structures scallop shell images periodic patterns structures consisting bifurcation points crossover points rings ribs connected lines could found space based depth first search sdfs algorithm created matlab package implement method periodic pattern extraction pattern matching digital scallop images available study results confirmed hypothesis shell cyclic structure patterns encompass genetically specific information used effective invariable biomarker biological individual recognition package available quick start guide includes three examples
flemish painters quentin massys son jan massys appear authors four works similar motif bust jesus christ canvasses found different locations today prado museum madrid spain rkd netherlands institute art history hague netherlands kunstmuseum winterthur switzerland another one private collection written edge robe around neck canvasses display series hebrew pseudo hebrew letters offer complete solution deciphered today incomplete three similar letter sequence finally resolve completely one canvasses today known solution
flotation response chalcopyrite molybdenite using novel compound acetic acid ydrazinylthioxomethypthiol sodium ahs depressant investigated micro flotation batch flotation study depressing mechanisms studied means zeta potential xps measurements micro bench flotation results indicated ahs exhibited strong influence depression chalcopyrite little effect flotation molybdenite minerals results might attributed significant improvement molybdenite chalcopyrite selectivity index addition ahs results ftir spectra zeta potential xps measurements indicated ahs chemisorbs onto chalcopyrite surface atoms forming five membered cheat ring possible depressant mechanism along postulated adsorption mode surface interaction ahs chalcopyrite provided elsevier rights reserved
flow characteristics around proximal distal stenoses tandem vessel models experimentally investigated varying flow rates min interspacing distances diameter severities reduction diameter interspacing larger fluid dynamic interaction observed flow proximal distal stenoses becomes stabilized turbulence intensity interspacing distance decreases severity transition laminar turbulent flow occurs flow rate higher min although interspacing distance formation recirculation flow restricted presence distal stenosis interspacing distance decreases case flow stenoses focused central region center line velocity neck distal stenosis approximately higher proximal stenosis equal severity inlet flow center focused lengths recirculation jet core behind distal stenosis increase decrease interspacing distance inlet flow turbulent transition laminar turbulent flow occurs early interspacing distance reduced upstream proximal stenosis exhibits increased severity pressure drop measured compared severity downstream distal stenosis increased flow rate min elsevier ltd rights reserved
flow inside turbomachines rotating channels operating away design point intrinsically unsteady two phase flow part load operation complicate analysis introducing additional challenges transient phenomena linked typical unsteadiness multiphase flows bubble formation coalescence breakdown segregation gas locking variable inlet flow compositions case slug flow require advanced analysis tools reveal local flow mechanisms responsible performance degradation instabilities general trends outlined air accumulation zones two phase flow patterns highly dependent machine design flow regimes vary homogeneous distribution fine bubbles evenly dispersed carried away main flow complex flow patterns especially phases separate bubbles coalesce forming gas pocket adheres wide portion channel wall tests performed multiphase pump laboratory recently installed norwegian university science technology allows complete optical access pump channels fine adjustments inlet configuration tip clearance gap air injected different locations producing transient regimes high speed camera provides interesting insight transient flow phenomena paper focuses specific ones irregular backflow swirl inlet section gas accumulation zones contribution tip leakage mixing flow pattern shift phase segregation relative flow reduced origin pump blockage increasing gas contents carried away water phase flow machine parameters response variation inlet flow tests performed various operating conditions rotational speed mixture composition impeller tip clearance study completed time frequency domain analysis pressure pulsations surging specific transient events
flux distribution generated heliostat field solar central receiver system scrs receiver needs carefully controlled necessary avoid dangerous radiation peaks temperature distributions maximize efficiency keep system safe state tasks imply selecting subset heliostats activated assigning one certain aiming point receiver heliostat field usually human control supervision potential limiting factor thus active research line define automatic aiming procedures fact general autonomous methodology developed authors work however mathematical modeling leads face complex large scale optimization problem work applying teaching learning based optimization tlbo population based large scale optimizer considered intended serve perform large explorations search space finally deploy local optimizers promising results considering computational cost objective function parallel version tlbo developed significantly accelerates procedure possibility included complex process remains viable additionally parallel version tlbo also linked generic open source library
focus study incorporating construction sectors within concept sustainable building essentially concerns resource management well waste management evident building construction one largest consuming activities non renewable resources natural materials worldwide simultaneously enormous amounts construction demolition waste generated construction works expand meet increasing demand considered economic loss also accelerating environmental threat therefore become crucial construction waste management evolve away long practiced traditional methodology proven economically ecologically inefficient toward sustainable alternatives prioritize waste recovery disposal within context study addresses management construction waste selecting case studies actual construction projects scrutinizing waste management data study took place university massachusetts amherst selected projects conform green building council standards thus study works estimating financial environmental returns attained recycling construction waste projects utilizing results data analysis study eventually sets statistical paradigm field based values typical construction projects followed guide indicating much cost saved much landfill volume relieved material waste recycled thereby study serves enhance sustainable management construction waste maximizing returns construction waste recovery elsevier rights reserved
folic acid analogue methotrexate used anti neoplastic agent treatment inflammatory disorders including psoriasis dermatomyositis lupus erythematous sarcoidosis systemic sclerosis despite introduction newer biologic agents methotrexate remains first line systemic therapy many patients disorders chronic inflammation briefly describe current clinical evidence methotrexate use psoriatic disease current understanding methotrexate anti inflammatory properties future role methotrexate treatment immune mediated disorders elsevier inc rights reserved
following article aims prove necessity adaptation construction management system eco model economical development article presents concept eco management basis integration ecological aspects system methods management tools according management functions content functions ecologization additional advantages ecological management construction business presented
following work considers application synchronous reluctance machine integer slot double layer concentrated stator winding large scale wind energy conversion system electrical generator general advantages drawbacks abovementioned machine type possible optimization methods mentioned proposed winding topology characterized low winding factor fundamental wave magnetomotive force made unconventional often used arrangement despite issue also certain benefits shown opposing another concentrated winding design higher fundamental winding factor performance analysis terms produced torque efficiency power factor field weakening performance active weight made
formation soluble oligomers amyloid beta beta beta initial event pathogenesis alzheimer disease based previous systematic proline replacement solid state nmr proposed toxic dimer structure beta highly aggregative alloform turn positions hydrophobic core terminal region however addition beta beta dimers also contribute progression abundance beta monomer biological fluids describe synthesis characterization three dimer models toxic conformation constrained beta using diaminopimeric acid dap diaminoazelaic acid daz linker position incorporated intermolecular parallel beta sheet region dap position terminal hydrophobic core aodap beta dimer aodaz beta dimer existed mainly oligomeric states even weeks incubation without forming fibrils unlike corresponding monomer neurotoxicity toward syy neuroblastoma cells weak contrast gdap beta dimer formed beta sheet rich oligomeric aggregates exhibited potent neurotoxicity corresponding monomer ion mobility mass spectrometry suggested high molecular weight oligomers mer form incubation findings indicate formation hydrophobic core terminus rather intermolecular parallel beta sheet triggers formation toxic beta oligomers compound may suitable model studying etiology alzheimer disease
formula calculating ultimate bearing capacity horizontal vertical reinforced soil investigated based failure mode mechanism sand beds reinforced horizontal vertical reinforcement two components soils reinforcement calculated separately ultimate bearing capacity shallow concentrically loaded strip footing homogeneous soil commonly determined using terzaghi superposition method contribution horizontal vertical reinforcement calculated based bearing resistance soil transverse members vertical inclusion treated retaining wall confinement calculated using rankine earth pressure theory analytical solution presented including traditional factors soil unit soil weight footing width number horizontal vertical reinforcement layers reinforcement geometry results validated experimental results mean error theoretical model maximum error elsevier ltd rights reserved
fragmentation mechanism low grade hematite ore high pressure grinding roll hpgr studied based characteristics comminuted products different specific pressure levels major properties included reduction ratio liberation specific surface energy specific surface area results showed fracture low grade hematite ore hpgr interactive dynamic process interaction coarse particles gangue minerals fine particles valuable minerals alternately continuous increased compactness compacting strength materials within range valuable minerals crushed preferentially absorbing energy whereas gangue minerals completely crushed acted energy transfer medium within range gangue minerals adequately crushed absorbing remaining energy whereas preferentially crushed valuable minerals acted energy transfer medium within range range low grade hematite ore comminuted size effect strength materials comminution effect materials became stable
french antilles martinique saint martin guadeloupe french guiana french territories affected hiv epidemic population groups men sex men msm especially involved transactional sex thought particularly vulnerable hiv data exist help characterize health related needs thus implement relevant prevention interventions fill knowledge gap used data collected hiv aids knowledge attitudes behaviours practices survey conducted among msm living french antilles french guiana recruited snowball sampling objectives compare social demographic characteristics sexual behaviours msm engaging transactional sex msm engaging transactional sex identify factors associated transactional sex involvement using logistic regression model total msm interviewed reported undergo transactional sex behaviour social demographic characteristics different msms exposed factors recognized potentiate hiv vulnerability individual community network structural levels variables positively associated sex trade involvement ever consumed drug greater number sex partners median experienced intimate partner violence undergone physical aggression sexual orientation variables negatively associated sex trade involvement older per year stable administrative situation stable housing employed full time
functional optimization neural ensembles central human higher cognitive functions functions neural activity tuned fail develop break symptoms cognitive impairments arise review considers ways disturbances balance excitation inhibition might develop expressed cortical networks association schizophrenia presentation framed within developmental perspective begins disturbances glutamate synaptic development utero considers developmental correlates consequences including compensatory mechanisms increase intrinsic excitability reduce inhibitory tone also considers possibility homeostatic increases excitability potential negative functional structural consequences negative functional consequences disinhibition may include reduced working memory related cortical activity associated downslope inverted input output curve impaired spatial tuning neural activity impaired sparse coding information deficits temporal tuning neural activity implication neural codes review concludes considering functional significance noisy activity neural network function presentation draws computational neuroscience pharmacologic genetic studies animals humans particularly involving methyl aspartate glutamate receptor antagonists illustrate principles network regulation give rise features neural dysfunction associated schizophrenia presentation focuses schizophrenia general principles outlined review may broad implications considering disturbances regulation neural ensembles psychiatric disorders
functional performances conventional roundabouts single lane multi lane innovative roundabouts spiral flower turbo improved right turn bypass lanes controlled stop yield free flow signs article presents evaluations emissions air pollutants carbon dioxide nitrogen oxides particle pollution fuel consumption construction management energetic environmental costs roundabouts without bypass lanes controlled stop yield free flow suggested methodology general character applied multi parametric criterion choosing road intersections although present paper employed case study aims research employed recent closed form formulations determine roundabout performances moreover used copert software estimate air emissions nine different types vehicles numerous traffic simulations carried variation maximum hourly traffic max annual traffic tot provided appropriate domains examined geometric layouts functional environmental terms regard generalized costs estimated year period resulted introduction right turn bypasses arms conventional roundabouts one ring lane one lane entries single lane roundabouts cost effective flows entering roundabout higher max veh moreover free flow bypass lanes always provide greater capacity lower delays stop yield signaled bypasses however extremely high max values stop controlled bypasses guarantee lower fuel consumption yield sign lower total costs
functions purinoceptors nervous system adults widely studied however little known roles embryonic development previous work reported extensive expression receptors adult mouse central nervous system present study examined expression pattern receptor mrna protein prenatal development mouse nervous system embryonic day receptors appeared neural tube early gradually confined new born neurons cortical plate ventral horn spinal cord heavy signals receptors also found dorsal root ganglia drg retina olfactory epithelium nerve fibers skeletal muscles conclusion receptors strongly represented developing mouse nervous system transient high expression pattern receptors epithelium like structures suggests role early neurogenesis
fusion hyperspectral imaging hsi sensor airborne lidar scanner als data provides promising potential applications environmental sciences standard fusion approaches use reflectance information hsi distance measurements als increase data dimen sionality geometric accuracy however potential data fusion based respective intensity information complementary active passive sensor systems high yet fully exploited approach rigorous illumination correction hsi data based radiometric cross calibrated return intensity information als data presented cross calibration utilizes ray tracing based fusion sensor measurements intersecting particular beam shapes developed method capable compensating drawbacks passive hsi systems cast cloud shadowing effects illumination changes time across track illumination partly anisotropy effects processing spatial temporal differences illumination patterns detected corrected entire hsi wavelength domain improvement classification accuracy urban vegetation surfaces demonstrates benefit potential proposed hsi illumination correction presented approach first step toward rigorous flight fusion passive active system characteristics enabling new capabilities variety applications
general class bianchi cosmological models dark energy form modified chaplygin gas variable lambda bulk viscosity considered discuss three types average scale factor using special law deceleration parameter linear time negative slope exact solutions corresponding field equations obtained obtain solution bulk viscosity cosmological constant lambda gravitational parameter deceleration parameter different equations state model describes accelerating universe large value time wherein effective negative pressure induced chaplygin gas bulk viscous pressure driving acceleration
geodesic curvature flow important concept riemannian geometry flow level set formulation many applications image processing computer vision material sciences etc existing discretizations triangulated surfaces based either finite volume method finite element method piecewise linear function space suitable vertex based two phase problems contour zero level set existing methods passes triangles mesh however graphic applications mesh segmentation divide whole mesh several sub meshes without ambiguous triangular stripes cutting contour needed along edges mesh moreover multi phase segmentation single level set function difficult problem long time paper try tackle two problems propose new discretization simpler formulation sparse coefficient matrix prove existence uniqueness regularization behavior maximum minimum principle discrete flow therein maximum minimum principal presented lots experiments show limit flow would piecewise constant solution discontinuity set closed geodesics surface therefore propose constrained discrete geodesic curvature flow also analyzed theoretically linear system constrained flow equivalently reformulated much smaller one especially narrow band algorithm dramatically reduces computation cost combined narrow band algorithm constrained flow topologically correct initializations easy got simple existing methods manual inputs yields multi phase segmentation method single level set function test two flows closed curve evolution multi region segmentation applications numerical experiments given demonstrate effectiveness
geotextile industry research development growing fast rate new products variable specifications available earthworks design engineers polypropylene fiber material non biodegradable stand aggressive chemical exposure placed along soil media research conducted polypropylene fiber reinforced soil treated chemical admixture order study interlocking mechanism study extent improvement tensile behaviour locally available plastic clay selected investigation extent improvement polypropylene fibres inclusion tensile behaviour evaluated carrying series brazilian tensile strength tests dominant mechanism responsible increase tensile strength properties proposed effect various geotechnical parameters like grain size distribution density moisture content tensile strength improvement discussed study shows addition polypropylene fibers alone highly plastic clay suffice tensile strength requirements polypropylene fibers added lime improve tensile strength depending dose fiber content
girder self anchored suspension bridge subjected large compression force applied main cables serious damage girder due breakage hangers may cause collapse whole bridge time increasing hangers may break suddenly resistance capacities decrease due corrosion using nonlinear static dynamic analysis methods adopting finite element model responses concrete self anchored suspension bridge sudden breakage hangers studied paper results show sudden breakage hanger significant effects tensions hangers next broken hanger bending torsion moments girder moments towers reaction forces bearings results obtained dynamic analysis method different obtained static analysis method maximum tension hanger produced breakage hanger exceeds times initial value maximum dynamic amplification factor reaches larger value recommended cable stayed bridge pti codes two adjacent hangers side bridge break one another maximum tension hangers exceeds times initial value safety factor adopted design hanger small hangers exposed corrosion bridge may collapse due breakage two adjacent hangers
global expansion aquaculture industry brought corresponding increase novel viruses infecting different aquatic organisms emerging viral pathogens proved challenge use traditional cell cultures immunoassays identification new viruses especially situations novel viruses unculturable antibodies exist identification viral metagenomics potential identify novel viruses without prior knowledge genomic sequence data may provide solution study unculturable viruses review provides synopsis contribution viral metagenomics discovery viruses infecting different aquatic organisms well potential role viral diagnostics high throughput next generation sequencing ngs library construction used metagenomic projects simplified task generating complete viral genomes unlike challenge faced traditional methods use multiple primers targeted different segments vps generate entire genome novel virus terms diagnostics studies carried far show viral metagenomics potential serve multifaceted tool able study identify etiological agents single infections infections tissue tropism profiling viral infections different aquatic organisms epidemiological monitoring disease prevalence evolutionary phylogenetic analyses study genomic diversity quasispecies viruses sequencing technologies bioinformatics analytical tools becoming cheaper easier anticipate metagenomics soon become routine tool discovery study identification novel pathogens including viruses enable timely disease control emerging diseases aquaculture
glycolipid biosurfactants mannosylerythritol lipids mels attract great attention biodegradability super emulsifying properties versatile bioactivities study mel deriving ceriporia lacerate chzju identified mel critical micelle concentration emulsifying activities assessed examine production mels ceriporia lacerate plackett burman design response surface methodology used optimize culture nutrients optimal medium contains yeast extract khpo cacl soybean oil mnso subsequent verification revealed yield mels furthermore unstructured kinetic model developed mycelial growth mel production substrate utilization work provides insight ceriporia lacerate chzju predominant fungus producing mel optimization using response surface methodology enhanced mannosylerythritol lipid recovery importantly developed fermentation kinetic modelling mannosylerythritol lipid production elsevier ltd rights reserved
goal ratio enhancement hyperspectral image pansharpening obtain enhancement ratio simulated low resolution panchromatic pan image original high resolution pan image however simulated low resolution pan image often suffers gray level distortion solve problems original bands synthesized smaller number reduced bands pixels pan images divided different groups according linearity pan band reduced bands pixel group nonnegative least squares algorithm utilized calculate weights reduced bands simulated pan image obtained weighted summation reduced bands finally image sharpened ratio enhancement experiments demonstrated proposed method good performance fusion quality society photo optical instrumentation engineers spie
goal current study examine whether differential neural attentional capture evaluative responses group homosexual relative group heterosexual targets occur social categorization end heterosexual participants presented pictures heterosexual homosexual couples picture viewing task designed assess implicit levels discomfort toward homosexuality explicit evaluations pleasantness toward images neural activity form electroencephalogram recorded presentation pictures event related potentials resulting stimuli examined participants also completed questionnaires assessed degree socialized gays lesbians results demonstrated relative straight couples larger amplitude observed response gay lesbian couples however gay lesbian couples yielded larger late positive potential straight couples moreover degree participants differentially directed early neural attention group lesbian versus group straight couples related familiarity homosexual individuals work provides initial understanding neural underpinnings attention toward homosexual couples suggests differences processing sexual orientation occur early may moderated familiarity
goal present research test convergent divergent validity strategies coping career indecision scci model questionnaire comprises three main coping stylesproductive coping support seeking nonproductive copingusing three samples young adults deliberating career choice study tested association scci career decision making profiles using sample young adults study tested relations scci emotional personality related career decision making difficulties using sample young adults finally study tested associations scci career decision self efficacy well five dimensions big five inventory using sample young adults three studies also tested scci incremental validity assessing ability predict individuals stages career decision making process measures results supported convergent divergent validity partially supported incremental validity scci theoretical counseling implications discussed suggestions future research presented
goal study find cost effective composition particle reinforced composite light weight sufficient mechanical properties matrix particulate composite unsaturated polyester resin reinforced alumina trihydrate particles part alumina trihydrate proportion replaced hollow glass microspheres reduce weight save costs order find influence light filler physical mechanical properties composites materials different percentages light filler prepared test specimens cut moulded sheets fabricated vacuum assisted extruder tensile strength indentation hardness measured barcol impressor density determined based experimental data multi criteria optimization problem formulated solved find optimal design material artificial neural networks hybrid genetic algorithm used optimal solution given pareto curve represent distinction density selected mechanical properties composite material composite material filled hollow glass microspheres showed loss tensile strength loss surface hardness compared composition without filler weight decreased compared initial composition addition hollow glass microspheres lower net value material increased
goal article promote clear thinking clear writing among students teachers psychological science curbing terminological misinformation confusion end present provisional list commonly used terms psychology psychiatry allied fields avoided used sparingly explicit caveats provide corrective information students instructors researchers regarding terms organize expository purposes five categories inaccurate misleading terms frequently misused terms ambiguous terms oxymorons pleonasms term explain problematic delineate one examples misuse pertinent offer recommendations preferable terms judicious use terminology psychologists psychiatrists foster clearer thinking students field large regarding mental phenomena
goal paper formalize validate model order determine pay adjustment basis mechanical functional performance transportation infrastructures model determine pay adjustment based life expectancy pavement variability main properties formulated five different paths points view used order obtain information model suitability robustness algorithm proposed estimate pay adjustment negative positive based life cycle cost analysis structural non structural deficiencies surplus characteristics detected five different methodologies used deriving demonstrate validity model depends position dispersion measures demonstrated model help analysing project construction management common framework analyses validation demonstrate proposed model efficiently overcome typical problems determination contract administration decisions based upon objective sound criteria needed practitioners researchers expected benefit outcomes study
goal research investigate effects automated testing software levels student reflection student performance self selecting subjects design examined performance students introductory computer programming classes participants given option using web cat software testing tool evaluate computer code student self reported levels reflection measured using kember reflective thinking survey
goal study compare sex specific prevalence rate serious sports injuries past year among students ages years low middle income countries lmics globally data nationally representative students participated global school based student health survey gshs analyzed using complex samples analysis gshs defines injuries serious cause least one full day missed school usual activities require clinical treatment students reporting one serious injury past year asked single serious injury proportion students reporting least one serious injury past year ranged median among boys median among girls proportion serious injuries past year sports related ranged among injured boys median among injured girls median common types sports related injuries broken bones dislocated joints reported median boys sports injuries median girls sports injuries although annual injury rates among early adolescents vary widely countries gshs shows sports injuries common globally among male female middle school students understanding global trends health risks various population groups adolescents allows community health partnerships proactively address health needs communities serve
goal study investigate use vibration based system identification methods detecting wind turbine blade delamination operating conditions subjected excitations earthquake ground motion particular multivariate singular spectrum analysis two subspace identification techniques tested detecting dynamic characteristics wind blade total two series experiments conducted verify proposed algorithms cases accelerometers installed blades measuring vibration response first test series performed laboratory motor spun smallscale customized wind turbine controlled angular velocities shaking table excited entire structure artificial damage introduced loosening bolts blade rotor connection second test conducted field vibration data collected operating small scale wind turbine blade vibration response analyzed time frequency analyses subspace identification tests confirmed estimation dynamic characteristics blade rotating frequency turbine system feasible results guide future monitoring studies planned larger scale systems copyright john wiley sons ltd
graphics processing units gpus used accelerating graphic calculations well developing general devices one used parallel platforms compute unified device architecture cuda allows implementing parallel multiple gpus obtaining high computational performance last years cuda used implementation several parallel distributed systems end introduced type neural networks nns inspired behavior queueing networks named random neural networks rnn method successfully used machine learning community solving many learning benchmark problems paper implement cuda gradient descent algorithm optimizing rnn model evaluate performance algorithm two real benchmark problems energy sources addition present comparison parallel implement cuda traditional implementation programming language
grasslands western jilin province china experienced severe degradation last years radial basis function neural networks rbfnn support vector machines svm used predict carbon nitrogen phosphorus contents leymus chinensis chinensis explore degree grassland degradation using matter element extension model rbfnn svm demonstrated good prediction accuracy results indicated severe degradation samples mainly concentrated levels growth chinensis shown limited either nitrogen phosphorus different stages degradation soil chemistry changed noticeably degradation aggravated represents destabilization chinensis community homeostasis soil salinization aggravates soil nutrient loss decreases bioavailability soil nutrients along destabilization ratios weakens photosynthetic ability productivity chinensis conclusion supported observations chinensis gradually replaced chloris virgata puccinellia tenuiflora suaeda acuminate mixed community elsevier ltd rights reserved
great east japan earthquake geje subsequent tsunamis occurred caused extensive severe structural damage interrupted numerous research activities however majority activities revived public health researches activities started follow population affected disaster mini review overview recent activities regarding epidemiologic studies miyagi prefecture region affected geje study processes able identify particular characteristics vulnerable populations provide ideas may help save lives reduce amount damage caused future disaster long term follow care survivors essential affected areas health professionals pay particular attention various diseases cardiovascular complications mental disorders furthermore building resilience social relationships community beneficial survivors ongoing cohort studies conducted disasters help minimize biases regarding survivors pre disaster information emerging cohort studies disasters find potential helpful novel indices identify characteristics vulnerable populations save lives reduce amount damage caused future disaster constant research consistently improved new data needs performed
growing diversity mother father relationship status led debate role fathers parenting little known however fathers participation parenting linked maternal well across different mother father relationship statuses using data fragile families child wellbeing study fixed effects well random effects regression models show overall fathers engagement children sharing child related chores negatively related maternal parenting stress fathers cooperative coparenting negatively related maternal parenting stress random effects model suggesting association driven selection factors little variation associations mother father relationship status selection factors controlled findings extend support current cultural emphasis benefits fathers active participation parenting mothers children even mother father relationship dissolved
growth beach tourism increased need acceptable practical sustainable policies overcrowding sand loss habitat destruction littering water pollution among others problems commonly documented arising booming beach activities objective paper identify management priorities estimate carrying capacity high use beach tourists perspectives way managers make informed decisions leading enhanced beach quality specific procedures fulfill objective progressively established identify potential actions address concerns facing beach environment body data collected means questionnaires results showed beach cleanliness safety information provision sediment habitat management overcrowding considered important tourists reflecting areas priority actions policy set avoid tourists overcrowding carrying capacity limit estimated people one time people daily basis scenario tourist enjoys average square meters beach space results focus group discussion suggest list potential actions targeting management priorities helps build participative policy approach sustainable beach development finally taking special care putting management priorities practice discussed facilitate beach management
growth energy consumption explosive current data centers super computers public cloud systems explosion led greater advocacy green computing many efforts works focus task scheduling order reduce energy dissipation order obtain energy reduction well maintain quality service meeting deadlines paper proposes dvfs enabled energy efficient workflow task scheduling algorithm dewts merging relatively inefficient processors reclaiming slack time dewts leverage useful slack time recurrently severs merged dewts firstly calculates initial scheduling order tasks obtains whole makespan deadline based heterogeneous earliest finish time heft algorithm resorting processors running task number energy utilization underutilized processors merged closing last node redistributing assigned tasks finally task slacking phase tasks distributed idle slots lower voltage frequency using dvfs technique without violating dependency constraints increasing slacked makespan based amount randomly generated dags workflows experimental results show dewts reduce total power consumption various parallel applications well balance scheduling performance
hardanger bridge longest suspension bridge norway among top longest suspension bridges world comprehensive monitoring system installed completed august monitoring system designed provide data used verify numerical methods used predict wind induced dynamic response slender bridges located complex terrain monitoring system outlined paper together preliminary analysis accuracy model used describe self excited forces acting bridge deck extensive wind tunnel testing performed design hardanger bridge achieve excellent aerodynamic behaviour cross section bridge deck experimental results aerodynamic derivatives describe self excited forces combined finite element model bridge predict wind natural frequencies damping ratios combined structure flow system numerical predictions compared results obtained measured data using data driven covariance driven stochastic subspace identification concluded model self excited forces provides wind frequencies damping ratios corresponds well observations measured data
hashemite kingdom jordan example country suffers high water scarcity additionally due economic drivers country phosphate potash extraction pharmaceutical production little fresh water remains generally polluted infrastructure often antiquated urban areas non existent rural areas also contributes poor water conditions spread waterborne diseases paper examines socioeconomic factors contribute diarrhea hepatitis macro level jordan discusses public policies government officials could use abate problems ordinary least squares time series models used understand macro level variables impact incidence diseases jordan public health expenditure significant impact reducing incidence furthermore investment sanitation facilities rural regions likely reduce number cases hepatitis perhaps surprising outcome importation goods services likely results decrease cases hepatitis however income little impact incidence diarrhea hepatitis
health status jamaican workers evaluated baseline workplace health promotion interventions socio demographic health status lifestyle data collected employees blood pressure glucose cholesterol levels body mass index measured study participants common illness reported study participants migraine headaches followed hypertension asthma based blood pressure measurements pre hypertensive mmhg stage hypertension mmhg stage hypertension mmhg furthermore overweight obese extremely obese study participants reported excessive fast food consumption last days high rates obesity hypertension fast food consumption reported study emphasized need focused health promotion strategies universality across institutions presented excellent opportunity national workplace health intervention programs
heat transfer combustion gases cylinder walls inside spark ignition engine key factor engine design due influence engine efficiency power emissions therefore lot research conducted order accurately model heat transfer engine design optimization purposes models found provide inaccurate predictions fuels significantly different gas properties compared traditional fossil fuels indicates models either properly include gas properties missing important properties formulation order construct general fuel independent heat transfer model new measurements need executed multiple fuels different properties designing experiment requires thorough understanding factors influencing heat transfer interactions paper literature review presented heat transfer measurements spark ignition engines order investigate effect engine factors heat transfer based review root cause analysis conducted identify independent factors affect heat transfer factors used set two experiments according design experiments methodology allows investigation effect different gas properties engine settings heat transfer consistent way results measurements motored operation discussed fired operation companion paper elsevier ltd rights reserved
heating demands currently fulfilled conventional technologies based fossil fuels however due rapid depletion environmental hazards fossil fuels focus shifted harness heat energy renewable energy resources solar energy general flat plate evacuated tubes collectors used water heating yet another technology known solar thermal tower stt used heating applications current study focussed real time performance analysis solar thermal tower water heating system climate conditions taxila pakistan initially mathematical model developed design small capacity solar thermal tower system system simulated using matlab five different climate conditions pakistan peshawar taxila multan karachi lahore potential assessment afterwards experimental setup developed taxila consisting cavity type receiver made stainless tubes heliostats made mirror complete instrumentation data measurements performance analysis presented terms temperature difference delta absorbed heat abs efficiency eta fixed variable positions heliostats selected days september february results showed maximum temperature difference fixed heliostats position degrees abs maximum efficiency however variable heliostats positions maximum value temperature difference achieved degrees resulted abs efficiency finally reasonable agreement simulated experimental results obtained climate conditions taxila elsevier rights reserved
hemodynamic alteration cerebral circulation caused geometric variations cerebral circulation arterial network circle wills cow lead fatal ischemic attacks brain geometric variations due impairment arterial network result incomplete cerebral arterial structure cow inadequate blood supply brain therefore great importance understand hemodynamics cow efficiently precisely evaluating status blood supply brain paper three dimensional computational fluid dynamics main cow vasculature coupled zero dimensional lumped parameter model boundary condition cow outflow boundaries developed analysis blood flow distribution incomplete cow cerebral arterial structures geometric models study cover arterial segments aorta cerebral arteries allow take account innate patient specific resistance arterial trees numerical simulations governing fluid mechanics performed determine cow arterial structural hemodynamics illustrating redistribution blood flow cow due structural variations evaluated coupling methodology five patient specific cases diagnosed absence efferent vessels impairment connective arteries cows velocity profiles calculated approach segments patient specific arterial structures found close doppler ultrasound measurements accuracy consistency hemodynamic results improved compared pure resistance boundary conditions based grouping five cases according occurrence unilateral occlusion vertebral arteries inter comparison shown flow reduction posterior cerebral arteries consequence unilateral vertebral arterial occlusion flow rate anterior cerebral arteries correlated posterior structural variations study shows coupling approach capable providing comprehensive information hemodynamic alterations pathological cow arterial structures information generated methodology enable evaluation functional structural status clinically significant symptoms assisting treatment decision making
hidden weighted bit function hwbf introduced bryant ieee trans comp revisited knuth vol art computer programming function seems simplest one exponential binary decision diagram bdd size property interesting cryptographic viewpoint since bdd based attacks receiving attention cryptographic community usable stream ciphers functions must also satisfy main criteria paper investigate cryptographic properties hwbf prove balanced optimum algebraic degree satisfies strict avalanche criterion calculate exact nonlinearity give lower bound algebraic immunity moreover investigate normality resistance fast algebraic attacks hwbf simple implemented efficiently high bdd size rather good cryptographic properties take account number variables much larger functions implementation efficiency therefore hwbf good candidate used real ciphers indeed contrary case symmetric functions allow fast implementation also offer attacker specific possibilities due symmetry structure suspected related dedicated attacks elsevier rights reserved
high energy consumption associated acceleration requires electric vehicles evs accelerate chosen speed optimally particularly urban driving cycles existing methods deal minimization acceleration energy without considering acceleration duration paper focuses solving multiobjective optimization problem moop two conflicting objectives minimization acceleration duration minimization energy consumption two approaches used reach desired speed using single acceleration value using multiple acceleration values approach demonstrative speed changes chosen problem solved using multiobjective genetic algorithms mogas results pareto optimal fronts obtained two approaches compared using suitable performance metrics validate reliability moga results statistical analysis carried furthermore nonparametric study wilcoxon signed rank test conducted compare effectiveness approaches found multiple accelerations effective minimizing duration energy consumption single acceleration duration multiple accelerations reduced energy consumption sensitivity analysis approaches electric motor model parameters conducted simulation results acceleration using preferred optimal solution based driving comfort pareto front knee suggested strong implication toward driving assistance
high prevalence child sexual abuse csa concerning particularly survivors increased risk multiple adverse outcomes including poor mental health across lifespan children born extremely low birth weight elbw participants ages age csa associated increased odds clinically significant internalizing externalizing problems among elbw participants exposed csa compared though confidence intervals wide age csa linked increased odds current lifetime non substance use psychiatric disorders however hold adjustment covariates statistically significant differences mental health outcomes observed nbw participants exposed csa compared nbw participants exposed survivors significant perinatal adversity also exposed csa may higher risk psychopathology fourth decade life elsevier ltd rights reserved
infinity loop shaping method known one robust controller design methods method design procedure consists two steps weight design derivation controller controller derived weighted plant suppress infinity norm transfer matrix consisting sensitivity function complementary sensitivity function therefore closed loop system achieves good tracking robustness however guideline weight design explicit design index weight given result time consuming tedious process often required tune weight paper provides new weight design method stable single input single output siso plant resulting weight guarantees upper bound performance level controller design means controller design weight design completely separated contrast lanzon work moreover weight designed using frequency responses accordingly avoid process system identification reduce conservativeness caused overestimate system uncertainty wiley periodicals inc
hirota bilinear method painleve backlund transformation used discuss soliton solutions dimensional generalized shallow water equation help symbolic computation multiple soliton solutions multiple singular soliton solutions hyperbolic function solutions trigonometric function solutions formally obtained soliton solutions possess abundant physical architectures graphs corresponding solutions show particular localized excitations interactions two solitary waves three solitary waves
history agent development litany expensive one solutions opaque uninitiated difficult maintain impossible use novel contexts outcome unfortunate result tendency apply monolithic architectures agent development require specialists build models extensive knowledge engineering hand tuning realize adequate performance address shortcomings developing methods align agent development best practices software engineering paper describe approach promotes modularity learning development validation intelligent agents specifically approach enables modeler decompose intelligent behavior required problem rather modeling environment implement component behaviors using tool best suited requirements close data loop agent environment early development process rather post hoc validation step
hiv aids epidemic provided one challenging problems treatment infectious diseases antiretroviral drugs made marked improvement controlling immunodeficiency state patients gained longevity concern lipid abnormalities came fore initial drugs produced form metabolic syndrome accompanied elevated plasma triglyceride concentrations furthermore drugs used control virus often metabolized manner interfered lipid lowering drug therapy antiviral agents improved many respects experience managing lipid disorders added greatly ability control problems well roundtable discussion conducted physicians involved management large cohorts patients hiv infection special interest reduction vascular disease risk national lipid association rights reserved
hla molecule presents immunomodulatory properties might inhibit immune responses interacting specific natural killer cell receptors kirdl ilt ilt thus hla might influence outcome situations fine immune system modulation required autoimmune diseases transplants cancer pregnancy majority studies regarding hla gene variability far restricted specific gene segment promoter coding untranslated region performed using sanger sequencing probabilistic models infer haplotypes propose massively parallel sequencing ngs bioinformatics strategy evaluate entire hla regulatory coding segments haplotypes inferred relying straightforward haplotyping capabilities ngs less probabilistic models hla variability surveyed two admixed population samples distinct geographical regions demographic backgrounds cyprus brazil haplotypes promoters coding utr extended ones detected brazil cyprus identical ones already described probabilistic models indicating haplotypes quite old may present worldwide elsevier ltd rights reserved
holoprinter technology based holographic stereograms generated fast development holographic display applications holographic recording image sequence information scene could real computer generated images used holographic stereograms initially start acquisition different image perspectives scene centering camera configuration images must rearranged optical recording paper proposes method acquire required images hogel images one step without using rearrange algorithms method uses virtual camera moves along virtual rail conventional computer graphics software proposed method reduced time required obtain hogel images enhance quality holographic images also applied different computer graphics software validate method full parallax holographic stereogram made computer generated object
human factor key variable efficiency product process development system ability able predict influence factor process significant challenge manufacturing engineering well consequences process designed factor ergonomic considerations traditionally evaluated without using product design nowadays process design technologies simulation tools allow opportunity earliest stages design process also used improve current processes order increase human comfort productivity safety paper describes methodology using design simulation tools improve industrial service processes methodology objective detection evaluation control work related musculoskeletal disorders wmsds
human visual system hvs attempts select salient areas reduce cognitive processing efforts computational models visual attention try predict relevant important areas videos images viewed human eye models turn applied areas computer graphics video coding quality assessment although several models proposed one applicable high dynamic range hdr image content work done hdr videos moreover main shortcoming existing models simulate characteristics hvs wide luminous range found hdr content paper addresses issues presenting computational approach model bottom visual saliency hdr input combining spatial temporal visual features analysis eye movement data affirms effectiveness proposed model comparisons employing three well known quantitative metrics show proposed model substantially improves predictions visual attention hdr content
hydraulic permeability performance geosynthetics important functional technical index field engineering application paper pore size characteristics series different specifications spunbond needlepunched nonwoven geotextile tested capillary flow aperture measuring instrument including average pore diameter maximum pore size pore size distribution permeability characteristics nonwoven geotextile measured vertical permeability measuring instrument including flow index vertical permeability coefficient study compressive properties nonwoven geotextile different pressure relationship average pore diameter flow index fit curve built regression equation calculate predict water permeability performance pore size characteristics
hydrotechnical society france founded purpose adequately represent interests french hydropower industry shf history creation world war described including beauvert hydraulic laboratory grenoble main projects actors journal houille blanche difficult years thus intended look back era glorious french advances hydraulic engineering also creation wwii
hydrothermal electrochemical deposition hed synthesis nise counter electrode dyesensitized solar cells dsscs shows excellent catalytic activity reduction triiodide hydrothermal electro deposition widely used synthetize nise herein fistly introduce hed produce nise material dsscs addition cyclic voltammetry curves tafel plots electrochemical impedance spectroscopy eis indicated hed nise shows better electrocatalytic activity reduction iodine iodide electrolyte nise dssc fabricated hed nise displays solar electricity conversion efficiency comparing convention reference significant higher based nise furthermore demonstrate hed method promising way design synthesize advanced materials utilizing solar energy elsevier rights reserved
identification acquired calr mutations patients essential thrombocythaemia myelofibrosis meant disease initiating mutations detected patients myeloproliferative neoplasm mpn show calr mutations cause frameshift thereby altering carboxy terminus calreticulin promote cytokine independence vitro frame deletions functional unlikely pathogenetic mutation underlying mpn cases expression thrombopoietin receptor mpl also necessary factor independence although calr mutations considered occur jak negative cases heterozygous state progenitor genotyping revealed always true notably calr mutation positive mpns polyclonal one case two distinct calr mutation positive subpopulations could identified another separate populations jak positive calr mutated cells present mitotic recombination involving chromosome third instance resulted emergence calr mutation homozygous subclone collectively studies demonstrate occasional patients calr mutation positive carry mpn initiating genetic mutations including jak acquire secondary mutations calr mutation evolve time calr mutation homozygous
identification plum varieties generally done base distinctive plant traits shape size fruit drupe color identified variety registration following official descriptors paper image analysis techniques applied study endocarps variability prunus domestica cultivars sardinia digital images acquired analysed using macro specifically developed measure morpho colorimetric endocarps features data later statistically processed applying stepwise linear discriminant analysis lda implement statistical classifier able classify variety identify plausible synonymy groups present study represent first attempt investigate morphology morphometry plum endocarps order characterize whole sardinian plum agrobiodiversity also evidence usefulness image analysis techniques taxonomic investigations well conservation enhancement traditional plums consumer satisfaction elsevier rights reserved
immunosuppressive effects dexmedetomidine highly selective widely used alpha adrenoceptor agonist sedation analgesia stress management investigated vitro present study respiratory burst human neutrophils separated venous blood evaluated dexmedetomidine treatment escherichia coli stimulation effects five concentrations dexmedetomidine evaluated rhodamine flow cytometer nitric oxide production nitric oxide synthase inos activity also determined using commercial kits results compared positive control responses respiratory burst without drug found dexmedetomidine significantly suppressed respiratory burst production inos activity stimulation coli dose dependent manner suppressive effects dexmedetomidine phagocytic activity human neutrophils associated respiratory burst coupled production
impact human activities via land use cover changes ndvi trends critical improved understanding satellite observed changes vegetation productivity drylands dominance positive ndvi trends sahel called greening sometimes interpreted combined effect increase rainfall cropland expansion agricultural intensification yet impact changes land use yet thoroughly tested supported empirical evidence present studies considered importance different seasonal ndvi signals cropped fallowed fields interpreting ndvi trends field types commonly merged single cropland class make use distinctly different phonology cropped fallowed fields use seasonal ndvi curves separate two field types fuzzy classifier applied quantify cropped fallowed areas case study region southern sahel fakara niger yearly basis find fallowed fields consistently higher ndvi unmanured cropped fields using two seasonal ndvi metrics amplitude decreasing rate derived modis time series clear separation classes fields achieved fuzzy classifier compute percentage pixel active cultivation thereby alleviating problem small field sizes region find predominant decrease ndvi period analysis associated increased area cropped fields expense fallowed fields findings couple cropping abandonment frequent fallow years positive ndvi trends increase percentage cropped area fallow period shortening negative trends findings profoundly impact understanding greening browning trends agrarian sahelian drylands drylands developing countries characterized limited use fertilizers elsevier inc rights reserved
impact presidential debates candidate evaluations remains open topic research long sought identify factors matter citizens responses debate content including candidates say say manner appear study uses detailed codings first third presidential debates evaluate impact candidates verbal nonverbal behaviors viewers second screen responsetheir use computers tablets mobile devices express reactions viewing experience examine relationship candidates screen behaviors social media response conduct generalized least squares regression prais winstein estimation relating two data sources shot shot content analysis coded rhetorical functional tonal visual elements candidates behavior debates corresponding real time measures volume valence online expression candidates twitter find nonverbal communication behaviors candidatestheir facial expressions physical gestures blink rateare consistent robust significant predictors volume valence public expression debates rivaling power memes generated candidates contributing rhetorical strategies speech tone
impact thyroid hormone disorders male reproductive biology controversial issue many years recently reported hypothyroid male rats disruption seminiferous epithelium may compromise spermatogenesis improve understanding reproductive pathogenesis hypothyroidism hyperthyroidism male wistar rats developed dysfunctions adulthood used experimental model evaluated sperm production reserves transit time morphology functionality acrosome integrity plasma membrane integrity mitochondrial activity testicular expression receptors thra thra thrb thrb deiodinases dio dio mct transporter slca assessed reverse transcription followed real time quantitative pcr qpcr results evaluated statistically anova tukey hsd test hypothyroidism decreased total daily sperm productions increased sperm transit time epididymis sperm functionality reduced thyroid dysfunctions regarding modulation gene expression testis hypothyroidism increased expression thra decreased expression dio hyperthyroidism increased expression slca observed alterations spermatic production function expression receptor deiodinase transporter suggestive participation spermatogenesis adulthood
importance brain inflammation alzheimer disease pathogenesis accepted late currently held brain inflammation aggravates pathology one important aspect brain inflammation recruitment activation microglia process termed microgliosis kinins bradykinin particular major pro inflammatory mediators periphery although factors comprising kinin system also described brain moreover shown amyloid beta beta peptide component plaques enhances kinin secretion activates receptors turn stimulate beta production still role bradykinin modulating brain inflammation completely understood study aimed investigate roles bradykinin receptor bradykinin receptor regulating microglial secretion pro inflammatory factors vitro furthermore effects intranasal administration specific antagonists beta burden microglial accumulation brains transgenic mice studied data obtained show neither antagonist hoe antagonist altered microglial cell viability however hoe markedly increased lipopolysaccharide induced nitric oxide tumor necrosis factor alpha tnf alpha release well inducible nitric oxide synthase expression microglial cells neither antagonist altered tnf alpha production non stimulated cells also showed intranasal administration hoe week old familial mice enhanced amyloid burden microglia macrophage accumulation cortex conclude provide evidence supporting role brain inflammation regulation amyloid deposition mice possibly microglial macrophage involvement studies required test whether modulation receptor serve novel therapeutic strategy
importance computer system security banks never exaggerated conducting risk assessment computer system security banks increase safety management ensure normal operation paper firstly figures risk assessment indexes computer system security banks literature review survey secondly uses ahp confirm weight indicators establishes five security levels according judgment experts finally establishes risk assessment model computer system security banks
importance learning improvement recognized process capability maturity modeling elaborated software engineering community became applicable process oriented activity assessment improvement paper contributes solution learning improvement problem based process quality attributes modeling approach consciousness learning process quality characteristic introduced two dimensional learning process model based marzano taxonomy learning objectives staged learning process maturity model developed validated authors published elsevier
impressive functions brain circuits inspired many scientists attempt designing neuron analogues using artificial molecular systems electronic devices however study molecular neuron produced equal variety models using vis absorption fluorescence resonance light scattering spectroscopies sensing common indicator congo red dye show congo red molecules used construct molecular neuron exhibit neuron like behavior molecular neural model uses molecular groups dendrites receive sense environmental stimuli inputs molecular matrix soma acts summation function change optical characteristics axon represents outputs approach allows utilize simple sensing molecules mcculloch pitts neuron experimental implementation large scale logic computation batch mode use extraordinary information density inherent molecular neuron alphanumeric information encoding molecular cryptography results suggest molecules could used universal artificial neurons capability sensing analytes environmental stimuli remembering patterns molecular events making decisions elsevier rights reserved
improved version author previously declared asymmetric cipher protocol based matrix power function mpf presented proposed modification avoids discrete logarithm attack dla could applied previously declared protocol attack allows transform initial system mpf equations called matrix multivariate quadratic mmq system equations system representing subclass multivariate quadratic systems equations making conjecture avoidance dla protocol presented increase security since attempt solve initial system mpf equations would appear less complex solving system mmq equations algorithms known solve system equations security parameters secure values defined security analysis chosen plaintext attack cpa chosen ciphertext attack cca presented measures taken prevent dla attack increase security protocol respect previously declated protocol
incidence hiv aids global problem still unresolved including banjarbaru indonesia highest cases occurred age group years indicating already hiv positive adolescence years cause high incidence hiv aids among adolescents influenced many things including lack knowledge hiv aids study aims determine effect counseling knowledge attitude banjarbaru midwife academy students study uses quantitative method pre experimental research design total sample people taken quota sampling results show number students good knowledge increased given counseling addition number students good attitude given counseling increased conclusion study counseling hiv aids affect banjarbaru midwife academy students knowledge attitude times respectively
incidence lymphedema related treatment women cancer breast gynecologic high treatment varies around world decades ago initially based programs including manual lymph drainage mld compression skin care easy exercise accumulating evidence experience time consider altering treatment principles needed based accumulating evidence suggest less emphasis manual lymph drainage early diagnosis compression weight control exercise improvement strength circulation
incidence writing disorder common reading disorder frequently identified rarely targeted intervention increasing clinical understanding various subtypes writing disorder assessment guided data driven decision making may alleviate disparity students writing disorders purpose article provide reader insight clinical reasoning involved assessment intervention planning child writing disorder reader guided authors conceptualization case reflecting recursive problem solving approach assessment intervention
increase authorship nuclear physics publications investigated using large statistical samples large collections bibliographical metadata represent powerful tool understanding past present perhaps future research trends accomplished nuclear data mining nuclear science references experimental nuclear reaction databases data analysis shows strong anticorrelation authorship increase experimental papers overall reduction measurements due closures many small nuclear physics facilities findings suggest article authorship complex phenomenon presently observed increase inflation authorship could explained adaptation changing research environment addition evolving authorship rules progressed years strict lenient results study implications discussed conclusions presented
increase installed capacity renewable energy sources res positive effect development smart grids demand side management dsm reason intermittent nature renewable energy directly related problem balancing production consumption power within power system using dsm power consumption system comprising res easier adjusted power production paper proposes improved concept dsm spatial temporal dsm optimal spatial temporal dsm aims determining power diagram individual load bus order achieve optimal state whole system optimal state system quantified minimum daily energy losses minimum daily operating costs mathematical definition optimal spatial temporal dsm problem presented well algorithm solution proposed methodology tested three test networks results confirm overall system performance improvements include reduction energy losses system reduction operating costs increase voltage quality within system elsevier ltd rights reserved
increase mobile applications social media daily generating huge volumes data variety data shapes evolving term known big data efficiently handling big data seems challenge meet rate data growth challenge played significant role indexing also correlating events across space time big data security analytics therefore paper introduces bloom filter space time efficient probabilistic technique variants summarized terms contributions network security domain besides variants evaluated characteristics big data security analytics conducting experiment huge volume data introduced technique along unsupervised learning engine tested results showed used overcome efficiency lacking space time indexing analyzing big data
increasing air pollution urban areas caused particulate matter poses problem human health plants able bind fine dust particles surface remove therefore air therefore roof plantings contribute reduction fine particulate matter pollution cities identify roof vegetation forms high filter ability suitable test procedures missing trials identify filtering potential different roof top vegetation mats conducted big perspex chamber controlled conditions geotextile mats sedum moss vegetation compared uncovered geotextile mats well crushed stones used controls measuring chamber artificial particulate matter fire fighting powder applied concentration particle fractions period min measured min middle minute measuring period wind speed height generated means ventilating fan particulate matter binding capacity different greening mats determined difference particle concentration application dust concentration maximum concentration end trial minute dust exposition significantly lower dust concentrations chamber registered treatments sedum mats compared controls reductions fraction fraction fraction particles none mat variations could bind particulate matter fraction wind speed however moss well sedum mats reduced particulate matter concentration fractions wind significantly compared controls high filter performance sedum explained due high surface plants extent plants bind uptake particulate matter outdoor conditions permanently cleared experiment however system allows measure differences binding capacity different rooftop greening sytems
increasing awareness damaging effects radiation human skin triggered market introduction new cosmetic absorbers article summarizes outcome multi year research program author contributed development different new filters first molecular design basic properties bis ethylhexyloxyphenol methoxyphenyl triazine bemt presented oil soluble filter today widely used beach products skin care products exhibits inherent photostability strong broad spectrum absorbance based concept micronized organic absorbers filter tris biphenyl triazine tbpt introduced present tbpt exhibits highest efficacy cosmetic absorbers market measured area spectrum finally concept liposomogenic absorbers featured approach developed create water resistant filters liposomogenic structures thought integrate lipids horny layer due prohibitively high costs technology result commercial product far
increasing functional integrity organism fetal maturation connected increasing complex internal coordination hypothesize time scales complexity dynamics heart rate patterns reflect increasing inter dependencies within fetal organism prenatal development investigated multi scale complexity time irreversibility fractal scaling fetal magnetocardiographic min recordings third trimester found different scale dependent complexity changes increasing medium scale time irreversibility increasing long scale fractal correlations changes results confirm importance time scales considered fetal heart rate based developmental indices elsevier ltd rights reserved
increasing levels criminal media shared peer peer networks pose significant challenge law enforcement agencies one main priorities investigators identify cases user actively engaged production child sexual abuse csa media indicators recent going child abuse although number monitoring tools exist detect paedophile activity networks typically rely hash value databases known csa media result tools able adequately triage thousands results retrieve identify new child abuse media released network paper present new intelligent forensics approach incorporates advantages artificial intelligence machine learning theory automatically flag new previously unseen csa media investigators additionally research extensively discussed law enforcement cybercrime specialists different european countries interpol approach implemented icop toolkit software package designed perform live forensic analysis network environment addition system offers secondary features showing line sharers known csa files ability see files shared guid addresses used client finally evaluation real csa case data shows high degrees accuracy hands trials law enforcement officers demonstrate toolkit complementarity extant investigative workflows authors published elsevier ltd
increasing population muslims america faces challenges uncommon faith immigrant communities one particular challenge muslim experiences various forms discrimination prejudice anti muslim bigotry microaggressions especially post america microaggressions discussed social sciences literature religious microaggressions clearly addressed social work literature article aims fill gap literature examining connections among racial microaggressions racialization religion ultimately religious microaggressions article concludes presenting implications social work policy practice education area religious microaggressions
influence reaction conditions synthesis hcn polymers water low temperature analyzed thermal stability hcn polymers obtained aqueous solutions inert atmosphere evaluated thermogravimetry differential scanning calorimetry dsc techniques addition situ mass spectrometry employed investigate characteristic functional groups decomposition residues different temperatures structural complexity polymericsolid reflected dtg curves hence peak deconvolution procedure applied deconvolution revealed complex thermal decomposition hcn samples occurs multiple overlapping processes perceptible curves weight loss influenced differences polymerization conditions addition great molecular diversity found macromolecular system also maintained dsc thermograms deconvolution dtg curves provided strong fingerprint hcn polymers together dsc complementary mark although full structures hcn polymers yet revealed deconvolution thermal curves provides excellent signature comparative purposes profile dtg dsc curves help design hcn polymers specific properties also help interpret remote sensing observations comets meteorites samples different planetary environments elsevier rights reserved
influence transglutaminase treatment changes physico chemical properties reconstituted skim milk different amounts added ethylenediaminetetraacetic acid edta studied partition salts inorganic phosphate determined experimentally atomic absorption emission spectroscopy colorimetry nuclear magnetic resonance spectroscopy calculated model salt partition milk based equilibrium thermodynamics hydrodynamic radius skim milk viscosity casein micelle medium resolution substructure measured dynamic light scattering rheology small angle ray scattering saxs respectively treatment milk influence partition salts upon addition edta crosslinking unlikely disrupt phosphate centre motifs short exon encoded amino acid sequences caseins however treatment prevented full dissociation casein micelles edta added induced higher viscosity increase untreated milk upon addition edta accordance particle sizing results saxs demonstrated treatment reduced extent edta induced micellar disruption compared milk without treatment elsevier ltd rights reserved
infrared stealthy theory introduced simply two kinds methods realization infrared stealth educed measures infrared stealth described detail world time pointed development infrared stealth materials basis development infrared stealth technology expounds performance characteristics stealthy materials detail finally development trend infrared stealth technology analyzed
initial value problems nonlinear stiff ordinary differential equation appear many fields engineering science particularly studies electrical circuits chemical reactions wave vibration research standard homotopy analysis method hybrids laplace transform method solve nonlinear stiff differential equations using modification problems solved lham successfully yield good solutions examples examined highlight convenience effectiveness lham
innate immune system first line defense invading pathogens one important feature innate immune recognition self versus nonself discrimination selectivity microbial ligands achieved substrate motif specificity spatial compartmentalization functions negative regulators loss function mutations negative regulators gain function mutations drivers innate immune signaling associated autoimmune diseases lupus rheumatoid arthritis inflammatory vasculopathy variety interferonopathies review focus trex sting opposing regulators cytosolic dna sensing pathway tremendous effort past decade among academic clinical research groups elucidated molecular mechanisms underlying immune diseases associated trex sting dysfunction also witnessed rapid therapeutic translation molecular findings several targeted treatment options druggable candidates available incurable diseases great enthusiasm academia industry partners look forward seeing remaining scientific questions answered importantly affected patients benefited discoveries
input output weight enumerator convolutional code characterizes distance spectrum allows error probability bounds conveniently evaluated efficiently compute weight enumerator pimentel recently introduced called state reduction algorithm convenient implementation using existing symbolic mathematical software paper propose dynamic state elimination ordering heuristic accelerate algorithm demonstrated empirical results accelerated state reduction algorithm achieve impressive complexity savings relative original algorithm applied compute weight enumerators various truncated versions convolutional codes moderate large constraint lengths
insulin producing beta cells pancreatic islets coupled connexin channels investigate controls expression connexin investigated pattern mouse pancreas development influence three transcription factors critical beta cell development differentiation show gene gjd activated early pancreas development markedly induced time surge transcription factors determine beta cell differentiation cognate protein detected week later selectively expressed beta cells throughout prenatal development mouse pancreas kbp fragment gjd promoter contains three boxes binding bhlh factor beta neurod ensures expression beta cells beta neurod binds boxes presence ubiquitous cofactor transactivates gjd promoter data identify novel early marker beta cells target beta neurod essential beta cell development differentiation
integrated chronic disease management icdm model introduced response dual burden hiv aids non communicable diseases ncds south africa one first efforts african ministry health aim icdm model leverage hiv programme innovations improve quality chronic disease care dearth literature perspectives healthcare providers users quality care novel icdm model paper describes viewpoints operational managers patients regarding quality care icdm model conducted case study seven phc facilities rural agincourt sub district northeast south africa focus group discussions used obtain data purposively selected patients years depth interviews conducted operational managers facility sub district health manager donabedian structure process outcome theory service quality evaluation underpinned conceptual framework study qualitative data analysed maxqda software identify priori dimensions care unanticipated themes emerged analysis manager patient narratives showed inadequacies structure malfunctioning blood pressure machines staff shortage process irregular prepacking drugs outcome long waiting times discordance managers patients regarding reasons long patient waiting time managers attributed staff shortage missed appointments patients ascribed late arrival managers clinics patients reported anti hypertension drug stock outs structure sub optimal defaulter tracing process rigid clinic appointment system process emerging themes showed patients reported hiv stigmatisation community due defaulter tracing activities home based carers managers reported treatment chronic diseases traditional healers reduced facility related hiv stigma hiv ncd patients attended clinic leveraging elements hiv programmes ncds specifically hypertension management yet achieved study setting part malfunctioning blood pressure machines anti hypertension drug stock outs implications nationwide scale icdm model south africa planning integrated chronic disease care low middle income countries
integration internet mobile internet internet things promote wide application industrial internet vertical internet smart device manufacturing smart internet marketing give people work life led profound changes experience walks network security problems become increasingly serious traditional networks variety viruses hackers threats expand network new system caused damage impact dangerous grim security analysis researching work needs extract network system resources related security well security factors establish security modeling security analysis paper takes introduction network security property cutting point combined safety requirements analysis level safety requirements discussing structure safety network platform well main connection relationship modeling
integrity oral digestive mucosa depend many salivary components like epidermal growth factor egf sometimes indicative sometimes stimulated modulated factor oral digestive health egf appears clinical marker neoplastic inflammatory diseases cellular growth factor protects digestive mucosa stimulation mucus production inhibition gastric secretion equally implicated healing process enhances one determines patients less sensibility inflammatory damages strategic place various pathologies stomach ulcer tumoral process open research prospects real potential repair pronostic editions scientifiques medicales elsevier sas rights reserved
interaction entomopathogenic fungus metarhizium robertsii natural avermectin metabolites actinomycete streptomyces avermitilis investigated colorado potato beetle larvae synergy mortality larvae detected simultaneous treatment half lethal doses avermectins commercial name actarophit fungus conidia treatment avermectins led rapid fungal colonization hemolymph defense strategies insects infected fungus treated avermectins untreated insects compared investigate mechanisms synergy shown increase hemocytes especially immunocompetent cells plasmatocytes granular cells initial stages mycosis third day post inoculation contrast avermectins suppressed cellular immunity hemolymph specifically avermectins dramatically decreased count granular cells larvae infected uninfected fungus apoptosis inducement hemocyte necrosis influence avermectins shown vitro one possible reasons hemocyte mortality addition avermectins enhanced activity phenoloxidases integuments hemolymph increased activity glutathione transferases activity fat body hemolymph infected uninfected larvae thereby intensifying development fungal infection robertsii colorado potato beetle larvae combination fungal infection avermectins constitutes new perspective developing multicomponent bioinsecticides elsevier inc rights reserved
interest present work focused improvement students learning process use wiki like platform research wiki intended mean order make easier learning project academic year area manufacturing engineering university oviedo involved project aim creation wiki nowadays software used auxiliary material subjects given manufacturing engineering area new engineering degrees created order adapt studies requirement european higher education area ehea according results obtained students stated higher mark student wiki better mark exam
international clearinghouse birth defects surveillance research reports rise prevalence rate spina bifida japan determined first trimester folate status hokkaido women identified potential predictors participants pregnant women hokkaido study environment children health cohort data extracted self reported questionnaires biochemical assay results demographic determinants low folate status younger maternal age adjusted aor lower educational level aor lower annual income aor plasma cotinine concentrations nmol increased risk low folate status aor concentrations nmol increased risk aor favourable predictor use folic acid supplements aor certain socio demographic factors influence folate status among pregnant japanese women modifiable negative positive predictors active passive tobacco smoking use supplements avoiding active passive tobacco smoking using supplements could improve folate status japanese women
internet movie database www imdb com largest successful website movie information yet crowdsourced contents sites like rarely studied therefore using imdb synopsis texts reviewers movie descriptions analyzed regarding movie contents subject many previous media studies violent behavior victimization male female film characters time analysis synopsis texts reveals perpetrators victims mainly male expectation violence becomes less severe often nonlethal years first time study using imdb texts identifies male female stereotypes suggests viewers descriptions seen could match findings traditional content analyses actual crime figures
internet things iot latest internet evolution incorporates diverse range things sensors actuators services deployed different organizations individuals support variety applications information captured iot present unprecedented opportunity solve large scale problems application domains deliver services example applications include precision agriculture environment monitoring smart health smart manufacturing smart cities like internet based services past iot based services also developed deployed without security consideration nature iot devices services vulnerable tomalicious cyber threats given protection received enterprise services within enterprise perimeter iot services play important role daily life resulting improved productivity quality life trend also encouraged cyber exploitation evolution diversification malicious cyber threats hence need coordinated efforts research community address resulting concerns presented special section several potential research topics also identified special section
internet things iot represents vision internet extends real world embracing everyday objects billions objects already connected internet objects would intercommunicate without human intervention would different operating systems enterprises developers produce different versions application functionality operating systems testing evaluating versions developers testers develop redevelop scenario versions application cross platform scenario module designed solve problem separating testing scenario events actions application execute events actions object scenario might written using data serialization formats extensible markup language xml javascript object notation json concise binary object representation cbor versions application example format used research xml
internet things promises continuous flow data traditional database data mining methods applied paper presents novel variant well known self organized map som called ubiquitous som ubisom tailored streaming environments approach allows ambient intelligence solutions using multidimensional clustering continuous data stream provide continuous exploratory data analysis average quantization error time used estimating learning parameters allowing model retain indefinite plasticity cope concept drift within multidimensional stream experiments show ubisom outperforms som proposals continuously modeling concept drifting data streams converging faster stable models underlying distribution stationary reacting accordingly nature concept drift continuous real world data streams
internet based phenomenon pro ana refers eating disorder anorexia nervosa positive way understand phenomenon pro ana represents websites used starting point current analysis based results similarities differences pro ana eating disorder anorexia nervosa discussed furthermore psychodynamic references anorexia nervosa derived finally importance treatment motivation considered
interpretation cor terms ideal sexual asceticism widely critiqued fallen favor majority scholars explain paul preference celibacy terms expedience serving lord avoiding affliction earthly life latter reason prefer celibacy article argues paul associates procreation marriage affliction warns marry order procreate expect affliction last days marriage sex simply avoid burning sexual desire leading sexual immorality children support paul abandons traditional obligation procreation procreative sex permits sexual abstinence agreement period fit something order devote prayer unstated purpose spare corinthians affliction result children coming days expected apocalyptic texts also refer use birth control family planning avoid suffering death
intraneuronal conversion testosterone oestradiol constitutes critical step development sexual differentiation brain many short gestation mammalian species inferred play similar role long gestation sheep conversion catalysed cytochrome aromatase cyp expressed specific brain structures foetal development present study undertaken examine specific neuroanatomical distribution relative expression aromatase mrna developing sheep hypothalamus foetal sheep highly tractable model system localising region specific expression aromatase brain prenatal development help predict regions oestrogen acts shape neural development results obtained using real time quantitative reverse transcriptase polymerase chain reaction revealed aromatase mrna expressed throughout mid late gestation foetal preoptic area amygdala preoptic area aromatase expression declined advancing gestation whereas increased amygdala sex differences observed either brain area next investigated anatomical distribution aromatase using situ hybridisation histochemistry found pattern mrna expression largely established midgestation high expression observed medial preoptic nucleus bed nucleus stria terminalis corticomedial amygdala also observed substantial expression dorsal striatum results extend understanding developmental expression aromatase foetal sheep brain lend support view plays essential role sexual differentiation maturation neuroendocrine motor reward control systems
introduction energy efficiency design index eedi ballast water treatment regulations international maritime organization fluctuation fuel price levels along continuous endeavor shipping industry economic growth profits led shipbuilding industry explore new cost efficient designs various types merchant ships respect proper use modern computer aided design computer aided engineering systems cad cae extends design space generating competitive designs innovative features short lead time present article deals parametric design optimization containerships developed methodology based caeses friendship framework software system demonstrated conceptual design multiobjective optimization midsized teu containership methodology includes complete parametric model ship external internal geometry development coding models necessary determination design constraints design efficiency indicators used evaluation parametrically generated designs indicators defining objective functions multiobjective optimization problem herein eedi required freight rate ship zero ballast container box capacity ratio deck number containers set multiobjective optimization problem solved use genetic algorithms clear pareto fronts generated identified optimal design proves competitive compared standard containership designs market
invariant moment feature target taken important approach human shape recognition paper gives general review moments zernike moments human shape recognition utilizes minimum distance classifier classify moving targets comparing characteristics specific applications paper provides basis selection invariant moments human shape recognition algorithm
investigation strain rate effects mechanical response characteristics thin free standing films crucial design fabrication reliable mems devices also high interest scientific materials engineering views paper present novel apparatus procedure tensile testing thin free standing films wide range strain rates quasistatic high almost comparable obtained hopkinson bar tests provide capability unique displacement measurement method applied micro device meets several strict requirements implemented describe recent results quasistatic experiments performed pure aluminum free standing thin films high rate experiment demonstrates setup capabilities also presented micro device measured properties compared finite element analysis results
involvement spinal nrb methyl aspartate nmda receptor subunit therapeutic effect electro acupuncture chronic visceral hyperalgesia investigated chronic visceral hyperalgesia induced using irritable bowel syndrome ibs model rats graded colorectal distention crd stimuli strengths mmhg applied behavioral tests performed measure abdominal withdrawal reflex awr response crd stimuli assess severity visceral hyperalgesia rats randomly divided four groups normal intact control group ibs model model group treated ibs rats group sham treated ibs rats sham group treatment electric stimuli applied needles inserted two acupoints san shang hind limbs sham treatment consisted insertion needles acupoints without application electric stimuli results showed awr scores model group responding crd stimuli mmhg significantly increased increased scores subsequently decreased following treatment compared groups expression nrb superficial laminae sdh laminae nucleus proprius laminae iii neck dorsal horn neck laminae central canal region lamina thoracolumbar lumbosacral segmental level significantly increased model group versus control group significantly decreased treatment significant changes neither awr scores expression nrb subunit spinal regions sham treatment results confirm relieve chronic visceral hyperalgesia ibs model rats suggest effect possibly mediated downregulation nrb subunits nmda spinal level
geo climatic origin gco theory admits primordial northbound migration africa increasingly demanded higher decreased aggression temperatures sank organisms fixed intra systemic energy budget meant small brained high masculine aggressive males became expensive cold eco niches replaced low testosterone androgyne light weight males sufficient energy developing large energy greedy brain needed survival cold winters physiological balancing nexus nexus traits probably occurred migration past years moderate heritability traits leads expect rudiments evolutionary progression still identified contemporary geographic race androtype distributions inversely related nexus traits rushton three racial ranking life history traits table nyborg issue confirms analyses using general trait covariance model data five races pentile bands evolutionary progression seems time limited however recent decennia witness decaying western civilization elsevier ltd rights reserved
iron complex amino triazole trz ligand potential applications smart material since compounds show distinct color change lilac low temperature colorless high temperature lilac color complex represent diamagnetic low spin state colorless correspond paramagnetic high spin state iron transition two states could tuned changing anionic group generally complex synthesized directly aqueous solution iron salt considerable amounts trz solution produced solid powder compound application electronic molecular device complex obtained thin film transparent trz nafion film successfully obtained however anion variation produced since nation anionic resin work trz complexes several anions synthesized inside nolo coco membrane commonly used medium deposition metal nano particles drying membrane containing complex became thin film room temperature film containing iron complexes sulphate nitrate salts show lilac color similar original complexes powder form heating color complex film changed colorless color change observed reversibly contrast films containing perchlorate tetrafluoroborate iron complexes colorless room temperature changed lilac cooling significant color changing iron complexes nata cow film used demonstration thermo chromic effect smart materials relatively small amount compounds
island nations territories south pacific facing number pressing environmental concerns including solid waste management coastal pollution provide baseline information presence concentration heavy metals selected organic contaminants pesticides pahs phthalates coastal streams surface waters adjacent futiga landfill american samoa sampled stream sediments contained high concentrations lead mercury several coastal stream waters showed relatively high concentrations diethyl phthalate organophosphate pesticides chronic toxicity values fish aquatic organisms parathion banned environmental protection agency since detected several stream sites increased monitoring initiatives limit non point source land based pollution greatly improve state freshwater coastal resources well reduce risks human health american samoa elsevier ltd rights reserved
isolated bladder shows autonomous micromotions increase bladder distension generate sensory nerve activity altered models urinary dysfunction intravesical pressure resulting autonomous activity putatively reflects three key variables extent micromotion initiation distances micromotions propagate overall bladder tone vivo variables subordinate efferent drive central nervous system micturition cycle storage phase efferent inhibition keeps autonomous activity generally low level may signal state fullness whilst maintaining compliance voiding phase mass efferent excitation elicits generalised contraction global motility initiation lower urinary tract dysfunction efferent control bladder impaired example due peripheral patchy denervation case loss efferent inhibition may enable unregulated micromotility afferent stimulation predisposing urinary urgency denervation relatively slight detrimental impact voiding may low adjacent innervated areas may able initiate micromotility synchronous efferent nerve drive even denervated areas contribute voiding contraction would become increasingly inefficient severe denervation ability triggered micromotility propagate sufficiently engage denervated areas voiding declines voiding contraction increasingly develops characteristics underactivity summary reduced peripheral coverage dual efferent innervation inhibitory excitatory impairs regulation micromotility initiation propagation potentially allowing emergence overactive bladder progression detrusor underactivity
issue children exposure violent video games source considerable debate several decades questions persist whether children pre existing mental health problems may influenced adversely exposure violent games even children explored issue children female mixed ethnicity mean age displaying clinically elevated attention deficit depressive symptoms pediatric symptom checklist results study found evidence increased bullying delinquent behaviors among youth clinically elevated mental health symptoms also played violent video games results support hypothesis children elevated mental health symptoms constitute vulnerable population video game violence effects implications suggestions research provided
iter pulsed power electrical network ppen supplies superconducting magnets heating current drive systems experimental pulses several hundreds seconds long active power consumption reactive one mvar expected iter power supply system large complex careful design required assure safe operation stability iter ppen already investigated recent studies numerical simulation analytical methods new dynamic analytical model iter power supply system developed based state space theoretical approach allows application linear control theory study stability whole system subsystem iter power supply state space model developed paper converter model presented validated six twelve pulse operation circulating current mode
iter steady state electrical network ssen distribution system provides approximately power supply conventional loads iter facility domestic agency responsible procurement kind contribution ssen equipment consists standard commercial grade power systems components paper reports lessons learned ssen procurement activity inform future procurement activities similar class equipment comprise high fraction overall iter procurements
janus kinase inhibitor oclacitinib licensed control pruritus associated allergic skin diseases dogs strikingly clinically reported abrupt withdrawal oclacitinib leads rebound pruritus dogs therefore primary objective study mimic rebound phenomenon oclacitinib using chronic pruritic mouse model allergic contact dermatitis chronic allergic contact dermatitis induced repetitive toluene diisocyanate tdi challenge balb mice oclacitinib orally administered twice daily days concurrent tdi challenge treatment oclacitinib abruptly discontinued scratching bouts following tdi challenge evaluated day additionally dorsal root ganglia drg affected skin isolated mice receiving oclacitinib mice oclacitinib withdrawal used determine pruritogen induced signals sensory neurons number activated dendritic cells dcs within drg cytokine profiles affected skin mice treated oclacitinib showed significant decrease scratching bouts treatment following abrupt withdrawal scratching bouts significantly increased furthermore following abrupt withdrawal drg neurons activated pruritogenic cytokines tnf alpha positive dcs significantly increased affected skin revealed significant increase tnf alpha tslp conclusion oclacitinib significantly reduced itch treatment abrupt withdrawal led rapid rebound phenomenon explained increase pruritogenic cytokines fast peripheral sensitization
japanese government approved use oral contraception users remain small minority japan using results online survey conducted examine factors determining japanese women choice contraceptive method estimating multinomial choice models estimation results indicate use positively associated age willingness pay contraceptive effectiveness frequency intercourse experience abortion emergency contraception findings suggest use increases women learn experience low declining frequency intercourse japan offers one explanation slow diffusion additionally findings indicate use prevalent among women higher risk unintended pregnancies subjective probabilities regarding contraceptive method contraceptive effectiveness disruption romantic moods partner disapproval side benefits minor non life threatening side effects important determinants contraceptive choice perceived risk levels side effects significantly higher population based probabilities implying increased medical knowledge might increase use
japanese guideline diagnosis treatment allergic diseases jagl includes minor revision japanese pediatric guideline treatment management asthma jpgl japanese society pediatric allergy clinical immunology section child asthma jagl provides information diagnose asthma infancy adolescence years age makes recommendations best practices management childhood asthma including management acute exacerbations non pharmacological pharmacological management guideline interest non specialist physicians involved care children asthma jagl differs global initiative asthma guideline jagl emphasizes diagnosis early intervention children asthma years years age first choice treatment depends severity frequency symptoms pharmacological management including step step drugs used long term management based status asthma control levels easy understand thus guideline suitable routine medical care children asthma jagl also recommends using control test children physician aims complete control avoiding exacerbating factors appropriately using anti inflammatory drugs example inhaled corticosteroids leukotriene receptor antagonists copyright japanese society allergology production hosting elsevier
jiuquan satellite launch center jslc relatively isolated special zone northwest region china potential risk energy supply security pressure national greenhouse gas emissions reduction clearly indicates jslc need lower dependency imported fossil fuels electricity article presents feasibility analysis available hybrid energy system based renewable energy availability local electricity demand estimation homer model simulation results indicate cost energy coe three proposed options kwh respectively also shows proposed hybrid renewable energy systems reduce carbon emissions compared electricity existing power grid sensitivity analysis reveals coe significant positive relationship carbon price discount rate whereas carbon price shows significantly distinct impact coe different options considered optimization results also show grid connected renewable power system comprised wind power natural gas power plant economic environment friendly energy supply option jslc however hybrid system local energy storage facility better guarantee energy supply safety considering special function security needs jslc study verified constructing new coal fired power plants suitable choice cost effectiveness kenvironmental protection perspectives elsevier rights reserved
job project manager exciting complex requiring range skills adaptability especially different culture effective therefore carry project therefore effectiveness facing multicultural team assigned international projects depends technical skills also large extent intercultural skills personal qualities including ability adapt collaboration different cultural environment research focuses context proposes study precisely relationship intercultural competence efficiency intercultural situations define relationship factors intercultural competence effectiveness intercultural situations four questionnaires one interview used sample subjects heterogeneous sample university limoges france factors person perception defined authors theorists four questionnaires used describe intercultural competences communication style emotional intelligence level potential role person could play part team first test used multicultural personality questionnaire mpq questionnaire used measuring group behavioral second test used communication style questionnaire used identify main communication styles within organization action oriented communication style process oriented communication style people oriented communication style ideas oriented communication style emotional intelligence questionnaire third test used identify importance basic skills determine success organization last test used belbin team role inventory also called belbin self perception inventory used measure preference team roles coordinator shaper monitor evaluator team worker implementer plant resource investigator finisher specialist team role added belbin research variables used age nationality residence urban rural high school graduate profile subjects worked collaborative activities projects beginning subjects informed research activity data confidentiality subjects average age years old regarding residency living urban residency living rural residency subjects nationality french chinese ivorian spanish swiss data collections used four questionnaires one interview data collection results began may ended july statistical processing performed specific version microsoft office excel sphinx plus lexica edition based literature review research identified cultural heterogeneity significant influence process could lead conflicts emergence negative impact teams results managing multicultural project teams ability manage diversity probably key skills required managers tomorrow
keep simple package includes short animated film available online streaming download lesson plan supporting materials designed used adolescents ages empower seek sexual reproductive health care emphasize availability long acting reversible contraception larcs materials package used together deliver minute educational session provides information teens sexual health services available local health centers rights obtain services link high quality adolescent friendly sexual health care animation also used standalone product components keep simple package available free also offered spanish compliques
key success surgical navigation based computer aided design computer aided manufacturing cad cam planning registration process precise adapted surgical needs however application conventional rigid skull fixed navigation star accurate registration limited use paediatric population risk unstable fixation dural perforation intracranial bleeding authors describe experience non invasive reference headband used combination custom made acrylic resin dental registration splint resection rare infraorbital zygomatic desmoplastic fibroma year old patient approach appears reported literature date
kinetics solid liquid extraction bioactive adenosine cordycepin mycelia sinensis studied hot water extraction carried temperature degrees mechanism extraction studied applying fick diffusion empirical models akaike information criterion aic employed selection best model among candidate models based aic parabolic diffusion model found best among competitive models high value diffusion coefficient adenosine cordycepin extraction respectively thermodynamic analysis process revealed extraction adenosine cordycepin feasible endothermic spontaneous temperature degrees elsevier rights reserved
korteweg vries kdv type equations seen fluid mechanics plasma physics lattice dynamics etc paper address bilinearization problem higher order kdv equations based relationship bilinear method bell polynomial scheme introducing auxiliary independent variable present general bilinear forms virtue symbolic computation one two soliton solutions derived
laminar boundary layer flow heat transfer casson non newtonian fluid inclined solar collector plate presence thermal hydrodynamic slip conditions analysed inclined plate surface maintained constant temperature boundary layer conservation equations parabolic nature normalized non similar form solved numerically well tested efficient implicit stable keller box finite difference scheme increasing velocity slip induces acceleration flow near inclined plate surface increasing velocity slip consistently enhances temperatures throughout boundary layer regime increase thermal slip parameter strongly decelerates flow also reduces temperatures boundary layer regime increase casson rheological parameter acts elevate considerably velocity effect pronounced higher values tangential coordinate temperatures however slightly decreased increasing values casson rheological parameter
laminar forced convection heat transfer water alo nanofluids horizontal rib microchannel studied middle section wall microchannel lower temperature compared entrance fluid simulations performed reynolds numbers nanoparticle volume fractions inside two dimensional rectangular microchannel length width two dimensional governing equations discretized using finite volume method effects rib hight position nanoparticle concentration reynolds number thermal hydraulics behavior nanofluid flow investigated results portrayed terms velocity temperature nusselt number profiles well streamlines isotherm contours model predictions found good agreements previous studies results indicate normal internal ribs turbulators significantly enhance convective heat transfer within microchannel however added high ribs cause larger friction factor compared corresponding microchannel constant height ribs results also illustrate increasing rib heights volume fraction nanoparticles friction coefficient heat transfer rate average nusselt number ribbed microchannels tend augment addition simulation results confirm changing solid volume fraction rib height cause significant changes temperature dimensionless velocity along centerline flow ribbed areas elsevier inc rights reserved
land mobile satellite radio channel satellite mobile terminal typical built environment calculated via constrained geometry based model replacing physical building facades clusters equivalent point scatterers properties scatterers terms power density angular spreading derived application physical ray tracing tool including specular well dense multipaths canonical street canyon scenario proposed approach also incorporates polarimetric model diffuse multipath scattering
langlands programme formulated robert langlands since much developed refined web interrelated theory conjectures concerning many objects number theory interconnections connections fields heart langlands programme concept function famous function riemann zeta function well ubiquitous number theory functions applications mathematical physics cryptography two seven clay mathematics million dollar millennium problems riemann hypothesis birch swinnerton dyer conjecture deal properties many different mathematical objects connected various ways functions study objects highly specialized mathematicians vague idea objects outside specialty everything related helping mathematicians understand connections motivation functions modular forms database lmfdb project mission chart landscape functions modular forms systematic comprehensive concrete fashion involves developing theory creating improving algorithms computing classifying hence discovering new properties functions testing fundamental conjectures lecture gave brief introduction functions non experts explained demonstrated large collection data lmfdb organized displayed showing interrelations linked objects website www lmfdb org also showed created worldwide open source collaboration hope may become model others
large mechanical forces throughout sternum upon tibia impact healing capacities following sternotomies upper tibia osteotomies respectively fields remains need materials strong adhesive capacity high mechanical strength set sufficient porosity allow osteointegration present work investigates castor oil based polyurethanes synthesized combined beta tricalcium phosphate beta tcp granules use bone graft substitutes adhesives load bearing regions material produced via reaction involving castor oil caprolactone monomers aliphatic diamine based catalyst water gas product creating pores throughout structure beta tcp particles diameter added mixture compose ceramic phase material setting completely hours adhesive cubic bone grafts exhibited structural porosity young modulus around mpa biocompatibility cell attachment tissue ingrowth apoptotic necrotic effects fully interconnected porous structure adhesive qualities adhesive bone graft material holds potential reconstruction challenging regions sternum upper tibia mandible furthermore bone grafts offered pre formed shelf products
last years seen explosion availability ownership use devices used access internet simultaneous increase number people viewing child abuse images ease access material online removed key inhibitor offenders technology facilitated distribution child abuse images also used prevent identify offending well manage offenders range technological tools currently used england wales manage offenders convicted accessing child abuse images living community specific computer situation crime article analyses evidence base article concludes tool features might contribute management internet child sex offenders none yet proven disproven effective copyright john wiley sons ltd key practitioner messages technology help manage risk posed internet child sex offenders developing may offer promise none technological tools proven disproven effective management tools internet child sex offenders offender managers police probation services mindful overly reliant robust evaluations types technology offenders needed
last two decades witnessed enormously rapid development computer technologies undoubtedly affected fields human activities including education fact computer science one evolving profile study programmes technical universities nowadays article thus focuses description key content courses curricula degrees offered within study programmes faculty informatics management university hradec kralove czech republic moreover study characterizes teaching learning university computer science professionals special focus core competences ability identify solve problems knowledge analytical methods operating systems also active passive knowledge english since english lingua franca help professionals together core competences succeed job market graduation key competences set basis questionnaire surveys experts evaluations also discussed article
lateral habenula lhb plays important role regulation depression present clear whether gaba receptor mediated inhibitory transmission lhb involved parkinson disease associated depression study unilateral hydroxydopamine lesions substantia nigra rats induced depressive like behaviors led hyperactivity lhb neurons compared sham operated rats attribute depletion dopamine decreased synthesis release gaba increased release glutamate lhb intra lhb injection gaba receptor agonist muscimol produced antidepressant like effects injection gaba receptor antagonist picrotoxin induced increased expression depressive like behaviors sham operated lesioned rats however doses producing behavioral effects lesioned rats lower sham operated rats intra lhb injection muscimol decreased firing rate lhb neurons increased medial prefrontal cortex serotonin release conversely picrotoxin increased firing rate neurons decreased release two groups rats compared sham operated rats duration muscimol picrotoxin action firing rate neurons release prolonged lesioned rats changes lesioned rats associated regulation expression alpha subunit containing gaba receptors reduction gaba release lhb collectively findings suggest degeneration nigrostriatal pathway impairs gabaa receptor mediated inhibitory transmission lhb transmission important regulating associated depression elsevier ltd rights reserved
lateral ponticle epitransverse process rare anatomical variations found atlas vertebra cervical spine lateral ponticle occurs abnormal bony bridge extends superior articular facet transverse process bony bridge bisects transverse foramen wherein vertebral artery normally lies case report describe specimen adult male lateral ponticle right side epitransverse process left side additionally articular facet like structure also found lateral ponticle surface relevant literature regarding lateral ponticle across age groups sex race species also reviewed postulate genesis lateral ponticle atlas occurs utero specifically lateral ossification ventral sclerotomes knowledge articular facet like structure ponticle reported previously moreover simultaneous occurrence lateral ponticle contralateral epitransverse process knowledge reported
laxative effects aqueous extract liriope platyphylla aetlp loperamide lop induced constipation reported however key compounds mechanism underlying effects remain unclear therefore laxative effects five candidates derived platyphylla diosgenin hydroxymethylfurfural hmf adenosine hydroxypropyl cellulose hpc uridine investigated examining alteration protein alpha expression protein kinase pkc phosphorylation inositol triphosphate concentration levels hydroxytryptamine serotonin receptor signaling pathway primary rat intestine smooth muscle cells prismcs intestinal epithelial cells iec cells cotreated lop five compounds order screen candidates aetlp prucalopride pcp bisacodyl served positive controls prismcs alpha expression levels recovered majority candidate treated groups whereas pkc phosphorylation recovery observed hmf treatment groups iec cells treatment group mimicked effects pcp pkc phosphorylation levels whereas hmf hpc treatment groups mimicked effects aetlp cells greater upregulation pkc phosphorylation levels observed treatment group compared pcp treatment groups whereas hmf treatment reduced pkc phosphorylation levels greater extent aetlp treatment however effects similar aetlp pcp alpha expression levels detected treatment groups iec cells furthermore level enhanced prismcs five candidates effective greatest concentration observed treatment group conclusion results present study suggest may considered compound greatest laxative activity may regulate receptor signaling pathway
learning habits new generation students growing cell phones access social media video games significantly different habits educators preparing future workplace effectiveness traditional lecture based classrooms questioned educators parents industry government field science technology engineering mathematics importance hands learning traditional classroom teaching underscores need curriculum reform paper presents methodology improve graduates knowledge skills area fluid mechanics ongoing curriculum reform process course syllabus reformed support multi modal student learning process beyond current lecture based classroom teaching tools developed foster flexible inductive learning hands applications online learning tools multipurpose laboratory equipped fluid power processes sensors data acquisition systems application programs established developed every semester laboratory experiments utilize fluid mechanics principles industrial applications provide students robust understanding subject practice industrial processes use sensors data acquisition hardware application programs laboratory technical skills program graduates improve significantly finally project evaluation assessment dissemination process monitoring evaluating project activities outcomes assessment student learning feedback continuous curriculum improvement presented
life cycle assessment several zinc oxide zno nanostructures fabricated facile microwave technique presented key synthesis parameters annealing temperature varied degrees degrees microwave power varied assessed effect parameters structural characteristics environmental sustainability nanostructures examined nanostructures characterized means ray diffraction xrd focused ion beam scanning electron microscopy fib sem ultraviolet visible spectroscopy vis photoluminescence brunauer emmett teller bet analysis crystalline site found microwave power microwave power synthesis temperature directly proportional surface area surface area found degrees degrees based life cycle analysis lca produced zno nanoparticles carried using zno surface area functional unit found main environmental weaknesses identified production process use ethanol purifying produced nanomaterials electricity consumption zno calcination provided south africa fossil fuel dependent electricity source effect key synthesis parameters environmental sustainability examined found increase either microwave power synthesis temperatures degrees results higher sustainability environmental footprint reduced respectively sensitivity analysis observed electricity mix based renewable energy could improve environmental sustainability nanoparticles elsevier rights reserved
life cycle kaposi sarcoma associated herpesvirus kshv consists two phases latent lytic virus establishes latency strategy avoiding host immune surveillance fusing symbiotically host lifetime persistent infection however latency disrupted kshv reactivated entry lytic replication viral lytic replication crucial efficient dissemination long term reservoir sites disease spread virus new hosts balance two phases kshv life cycle important virus host control switch two phases extremely complex various environmental factors oxidative stress hypoxia certain chemicals shown switch kshv latency lytic reactivation immunosuppression unbalanced inflammatory cytokines viral infections also lead reactivation kshv review article summarizes current understanding initiation regulation kshv reactivation mechanisms underlying process viral lytic replication particular central role immediate early gene product rta kshv reactivation extensively investigated studies revealed multiple layers regulation activation rta well multifunctional roles rta lytic replication cascade epigenetic regulation known critical layer control switch kshv latency lytic replication viral non coding rna pan demonstrated play central role epigenetic regulation serving guide rna brought chromatin remodeling enzymes promoters rta lytic genes addition novel dimension regulation micropeptides emerged shown regulate rta expression protein level overall extensive investigation kshv reactivation lytic replication revealed sophisticated regulation network controls important events kshv life cycle
liquidus temperatures phase relations bearing slag systems play important fundamental guiding role comprehensive utilization resources lack thermodynamic information severely restricts development mentioned systems present work phase equilibrium relationships investigated cao sio mgo alo tio phase diagram system equilibrium phases experimentally determined degrees degrees using high temperature equilibrium technique followed ray fluoroscopy xrf ray diffraction xrd scanning electron microscope sem energy dispersive ray spectroscope edx analysis liquid phase melilite solid solution phase cao center dot mgo center dot sio cao center dot alo sio perovskite phase cao center dot tio dicalcium silicate phase cao center dot sio found based experimental results degrees degrees isotherms phase relations obtained cao sio mgo alo tio system relevant bearing slag system elsevier rights reserved
literature pertaining rehabilitation ice hockey players seeking return sport anterior cruciate ligament reconstruction aclr currently limited purpose clinical commentary present criterion based progression return ice hockey athletes aclr first review pertinent literature provide previously published guidelines general rehabilitation aclr present phase ice skating progression objective criteria initiate phase early ice phase athlete reintroduced specific demands including graded exposure forward backward crossover skating intermediate ice phase emphasis shifts developing power introducing anticipated changes direction within controlled environment late ice phase focus progresses developing anaerobic endurance introducing unanticipated changes direction still without players contact finally objective return sport criteria met noncontact team drills outnumbered even numbered drills practices scrimmages games progressively reintroduced return sport phase recommendations ice strength conditioning exercises complement ice progression additionally apply return hockey progression framework case report female collegiate defensive ice hockey player returned sport successfully aclr criterion based return hockey progression may guide rehabilitation specialists managing athletes returning ice hockey aclr
local material behaviour cast metal injection moulded parts highly related geometrical design part well large number process parameters order use structural optimization methods find geometry gives best possible performance geometry effect production process local material behaviour thus considered work multidisciplinary methodology consider local microstructure based material behaviour optimizations design engineering structures presented adopting knowledge based industrial product realisation perspective combined previously presented simulation strategy microstructure based material behaviour finite element analyses fea methodology integrates computer aided design cad casting injection moulding simulations fea design automation multi objective optimization scheme novel structural optimization method cast metal injection moulded polymeric parts different concepts modules methodology described implementation prototype software outlined application relevance methodology discussed elsevier ltd rights reserved
main aim article present usage type fuzzy logic controller control shape memory actuator one main advantages fuzzy systems require creating mathematical model controlled plant simplifies control task however dynamic system model created adjust proportional integral derivative controller parameters different types controllers tested experimentally controlling position commercially available shape memory alloy actuator made miga motor company despite small size distinguishes strength enhance real time performance simplified interval fuzzy sets used algorithm implemented atmega microcontroller dedicated application also built obtained results confirmed type fuzzy controller performed efficiently nonlinear plant difficult control research also proved interval type controllers simplified version general type controllers efficient handle uncertainties without increasing drastically computational complexity experimental data comparison proportional integral derivative reference fuzzy logic controller type type clearly indicates superiority former especially reducing overshooting
main aim review provide broad overview social cognitive theory research applied violent sexual offending behaviour review suggests variation adoption social cognitive theory methods differing offending behaviours violent offending literature example many examples novel social cognitive research methods used examine cognitions highly aggressive men child sexual offending literature examples social cognitive techniques advantages adopting social cognitive perspective differing offending behaviours examined discussed alongside suggestions future research social cognitive domain
main aim study analyse roles played associative activation thematic extraction explanation false memories using deese roediger mcdermott drm paradigm associative lists two different types critical items cis used one associative corresponded word strongly primed associates list another thematic word best described theme list following three different types encoding instructions standard warning strategic false recognition two types cis analysed either self paced speeded response recognition tests results showed considerable levels false memories types cis even without quality good themes associative cis produced high levels false recognition suggests associative activation plays prominent role false memory formation interestingly thematic cis prone edited reinforcing argument thematic identifiability major role rejection false memories
main contribution paper present workoptimal parallel algorithm lzw decompression implement cuda enabled gpu since sequential lzw decompression creates dictionary table reading codes compressed file one one easy parallelize first present work optimal parallel lzw decompression algorithm crew pram concurrent read exclusive write parallel random access machine standard theoretical parallel computing model shared memory present efficient implementation parallel algorithm gpu experimental results show gpu implementation performs lzw decompression milliseconds gray scale tiff image pixels stored global memory geforce gtx hand sequential lzw decompression image stored main memory intel core cpu takes milliseconds thus parallel lzw decompression global memory gpu times faster sequential lzw decompression main memory cpu image show applicability gpu implementation lzw decompression evaluated ssd gpu data loading time three scenarios experimental results show scenario using lzw decompression gpu faster others
main focus paper two dimensional analog filtering development bivariate bifrequency theory autonomous dynamic systems circuits reviewed two dimensional laplace transform techniques make possible characterize large class analytic systems analog linear time varying systems circuits bifrequency theory corresponding analysis techniques outlined contents existing literature complemented duplicated
main objective paper introduce state space representation tracking error marine vehicle using combination mathematical statistical models end statistical model named cubic exponential weight wavelet network arx cew wnn arx model introduced cew wnn arx model arx model whose coefficients approximated cubic exponential weight wavelet neural network cew wnn cew wnn enhanced type wavelet neural network comprising five layers input wavelet product output cubic exponential weight layer computes weights cubic exponential function inputs thus allowing vary inputs share dynamics wavelet compartment cew wnn arx model possesses advantages state dependent arx model description nonlinear dynamics using nodes cew wnn model functional approximation considering mutually time frequency domains firstly nonlinear dynamic heading angle deviation rudder angle ship characterized cew wnn arx model later identified snpom heading angle deviation integrated mathematical model finally state space representation tracking error derived effectiveness proposed model shown using data obtained shioji maru experimental ship tokyo university marine science technology japan
main objectives scada supervisory control data acquisition systems supervisory analysis system control algorithms validation data acquisition systems normally implemented according international standards une iso isa luman machine interfaces isa case treated paper spanish royal decree paper presents software architecture development educational laboratories industrial virtual plants models logic implemented matlab used within labview appropriate protocol labview national instruments specific purpose software kind applications used since allows provide friendly interface perform communications data acquisition information management addition illustrate use proposed architecture different virtual industrial plants students different bachelor master degrees engineering university almeria developed paper shows different virtual industrial plants developed using scada systems facilitate students learning basic concepts techniques industrial informatics course ifac international federation antomatic control hosting elsevier ltd rights reserved
main problem utilization ceramic nanopowders consists tendency form hard agglomerates inter agglomerate space forms pores surrounded numerous elementary particles crystallites pores easily removed system pressureless sintering obvious strategy technologist eliminate pores level shaping operations dry pressing frequently applied shaping technique ceramic materials mechanical strength agglomerates low possible enables elimination inter agglomerate pores occur moderate pressures applied shaping process problem illustrated using really nanometric zirconiayttria solid solution powder methods effecting agglomerate strength shown one elaborated powder preparation rout results extremely soft agglomerates
main purpose optimization relay coordination extensively large electrical network enhance selectivity time reducing fault clearing time improve reliability system relays provided set function properly normal well abnormal condition paper main focus find minimum time dial setting tds relays connected whatever configuration using flower pollination algorithm said algorithm compared linear programming technique algorithm implemented matlab tested radial feeder fed one end well parallel feeder system innovative feature paper application nature inspired algorithm one major problem optimization field power system protection
main purpose present study investigate potential gender moderate relationships facets impulsivity severity problematic internet use piu among male female university students iran study individuals male female completed impulsive behavior scale short form lynam problematic risky internet use screening scale jelenchick computers human behavior multidimensional structural equation modeling used investigate moderating role gender relationship aspects impulsivity piu severity general model including genders models males females separately hypothesized relationship impulsivity piu severity demonstrated good fit data analyses also suggested structural relations equivalent groups regression weights general model two groups statistically significant amongst males females model predictor variable accounted respectively variance piu severity findings suggest impulsivity may predict piu severity similarly among iranian university students genders
main purpose work describe case online java programming course engineering students learn computer programming practice non technical abilities online training self assessment teamwork use foreign languages important students develop confidence competence skills required later professional tasks engineering courses life long learning furthermore paper presents pedagogical methodology results drawn experience objective performance comparison another conventional face face java course
main source electricity brazil hydro share country electric energy matrix however last decade wind energy increased since wind intermittent energy source heavily determined weather climatic conditions important effects wind power generation expected mid long term particular related impacts extreme winds ipcc intergovernmental panel climate change indicates changes wind speed surface regions world increased wind strength mid latitude regions study scrutinizes future scenarios extreme winds brazil applying trend analysis techniques year historical series observational wind speed meteorological parameters height brazil embracing techniques cluster analysis possible characterize six main regions macro climatic similarities assess goodness fit distribution designate two stations per homogenous region taking criteria stations better performance qualification process determine wind distribution pattern region applying kolmogorov smirnov test lowest standard error evaluating frequency distribution wind speed best fit result frequency distribution maximum wind speed gumbel model analysis climatic trends performed mann kendall test revealed minimum wind speed series conclusive shows disparate results homogeneous regions hand analysis climatic trends maximum wind speed presents positive trends group equal number stations significant trends positive trends group stations positive trends negative trends group stations negative trends stations positive trends group way based results possible assert increase maximum extreme wind brazil mainly mid latitudes published elsevier ltd
major factors control performance reinforced soil structures interaction soil reinforcement thus necessary obtain accurate bond parameters used design structures evaluate behavior flyash clay soil reinforced woven geotextile unconsolidated undrained reinforced consolidated undrainrained triaxial compression tests conducted moisture content soil remolding confining pressures arrangement geotextile layers varied behavior sample could examined stress strain patterns drainage modulus deformation effect confinement pressures effects moisture content evaluated impact moisture content flyash clay backfills critical shear parameters also studied recommend placement moisture compaction mdd results indicate geotextile reinforced flyash clay backfill might viable alternative reinforced soil structures good quality granular backfill material readily available
majority adolescents initiate sexual activity teenage years making contraception important aspect routine adolescent health care despite common mis perceptions available methods reversible contraception appropriate adolescent use contraceptive side effects profiles barriers use certain methods considered providing contraceptives adolescents particular ease use confidentiality menstrual effects main concerns adolescents contraceptive counseling adolescents describe method efficacy discuss user preferences explore barriers use counsel regarding sexually transmitted infection prevention consider contraception fails emergency contraception widely discussed adolescents appropriate use gaps contraceptive use method failure adolescents using another form contraception dual method use condom plus highly effective method contraception gold standard prevention pregnancy sexually transmitted infections
majority tinnitus patients affected chronic idiopathic tinnitus almost different treatment modalities reported present study multidisciplinary systematic analysis evidence different forms treatment chronic tinnitus results used form basis guideline systematic search carried pubmed cochrane library basis presenting level evidence evidence classification oxford centre evidence based medicine whenever available randomised controlled trials given preference discussing therapeutic issues systematic reviews meta analyses assessed methodological quality effect size taken account need patient counselling self evident specific tinnitus counselling performed due high level evidence validated tinnitus specific cognitive behavioural therapy strongly recommended addition auditory therapeutic measures recommended treatment concomitant hearing loss comorbidities also treated drugs whenever appropriate particular depression treated pharmacological support necessary needed psychiatric treatment also given case case basis simultaneous deafness hearing loss bordering deafness also indicated auditory therapeutic measures transcranial magnetic direct current stimulation specific forms acoustic stimulation noiser masker retraining therapy music coordinated reset treatment chronic tinnitus currently available evidence yet sufficient supporting recommendation
material design alkali activated slag aas contributes development sustainable green building materials recycle industrial waste energy reservation cement materials production computational simulation technique based reactive molecular dynamics proposed new view molecular structure main hydrate gel aas paper structure dynamics mechanical properties gel investigated proposed model exhibits heterogeneity layered features ordered stable atomistic arrangement calcium sheets disordered chemical connections interlayer region structurally atoms bridge neighboring oxygen atoms defective silicate chains contributing polymerization gel increase significantly enhance mean silicate chain length structure introduction atoms interlayer region improve mechanical properties gel therefore mean chain length taken important parameter guide high performance materials design elsevier ltd rights reserved
materialization memory one way past becomes powerful agent negotiating present today botswana archaeological sites become sites memory ancestors invoked healing response rapid spread hiv aids paper concentrates one site khubu dintsa local community practiced ancestral healing ceremony phekolo way restore spiritual balance told set narratives integrate ethnographic interviews one former church elders russia article chronicles trajectory church perceived power active role ancestors ceremony complex web morality practicality alternative narratives emerge time social disruption later fall apart paper complements others issue focusing memory place time material culture recursively engaged process includes formal accepted marginal even ephemeral viewpoints holds lessons archaeologists approach curate past
max plus linear systems studied almost three decades however well established system theory specific systems still going research geometric control theory particular proposed future direction max plus linear systems cohen cohen gaubert quadrat max plus algebra system theory annual reviews control article generalises kalman abstract realisation theory traditional linear systems fields max plus linear systems new generalised version kalman abstract realisation theory provides concrete state space representation set theoretic representation canonical realisation transfer function also leads computational methods controlled invariant semimodules kernel equivalence kernel output map controlled invariant semimodules play key roles standard geometric control problems disturbance decoupling problem block decoupling problem queueing network used illustrate main results article
mechanical properties cast iron used trunk mains water industry studied specimens sourced nine different pipes service years failure bulk microstructures cast iron analysed regard graphite flake morphology size stress strain behaviours tension compression derived specimens loaded flexure flexural strength data obtained specimens pipe three batches different locations along length around circumference pipe data analysed using weibull methods depth graphitisation visible fracture surface sample measured shown strength cast iron samples decreases increasing depth graphitisation layer graphitised material reasonably uniform thickness strength reduction modest section loss local strength reduction significant samples reduction strength depth graphitisation exceeds simple strength materials fracture mechanics approaches shown provide reasonable bounds data elsevier rights reserved
mechanical properties base alloys drawn considerable attention owing wide application hot components aircrafts gas turbines accurately measure deformation based alloys high temperatures new type high temperature speckles fabricated surface specimens subjected long heating durations temperatures degrees meanwhile novel measurement method based scale invariant feature transform algorithm developed measure deformation obtain accurate result proposed methods used creep test inconel degrees experimental results indicate speckles exhibit excellent performance heating conditions adhere well substrate high temperatures also proposed deformation measurement method exhibits superior image processing even speckle quality imperfect respect speckle size
mechanical strength conventional epoxy resins drops dramatically irradiation fast neutron fluence mev recent results demonstrated cyanate ester epoxy blends affected fluence level aim study investigate performance potential blends higher fluence levels without significant degradation mechanical properties short beam shear well static tensile tests carried prior irradiation fast neutron fluences mev triga reactor ambient temperature addition load controlled tension tension fatigue measurements performed order simulate pulsed operation conditions tokamak initial results show small reduction mechanical strength static dynamic load observed fast neutron fluence mev exposure mev interlaminar shear strength materials cyanate ester content reduced
media condemned contributing crimes glamorizing publicizing criminal acts dynamic come known copycat contagion research focuses risky behaviours pakistani adolescents exposed crime shows television may resulted become juvenile delinquents juvenile delinquency serious problem worldwide pakistan objective research identify popular television crime shows among adolescents find pakistani adolescents learn crime method television crime shows investigate describe negative aggression positive fear bad consequences hate crime effects television crime shows behaviour pakistani adolescents identify role socio economic factors influence pakistani adolescents crime learning behaviour finding paper found studies juvenile delinquency respect media especially affects aggression deviant peers contribute serious offending child delinquents period transition adolescence published future academy www futureacademy org
mental health consequences disasters including oil spills well known goal study examine whether social capital social support mediate effects exposure deepwater horizon oil spill depression among women data analysis come first wave data collection women children health study longitudinal study health effects women exposed oil spill southern louisiana usa women interviewed exposure oil spill depression symptoms structural social capital neighborhood organization participation cognitive social capital sense community informal social control social support structural equation models indicated structural social capital associated increased levels cognitive social capital associated higher levels social support turn associated lower levels depression physical exposure oil spill associated greater economic exposure turn associated higher levels depression variables taken account economic exposure longer associated depression social support cognitive social capital mediated effect economic exposure depression explaining effect findings support extension deterioration model social support include additional coping resource social capital social capital social support found beneficial depression post oil spill however negatively impacted oil spill explaining overall negative effect oil spill depression better understanding pathways social context depression could lead interventions improved mental health aftermath disaster elsevier ltd rights reserved
mental representation self complex construct comprising conceptual information perceptual information regarding body evidence suggests conceptual self representation bodily selfrepresentation malleable different aspects self linked changes bodily self representation appear affect self conceptualized unclear whether opposite relationship also true changes conceptual self representation affect physical self perceived first adopted perceptual matching paradigm establish association self unfamiliar face experiment robust attentional perceptual biases processing newly self associated object suggested conceptual self representation extended include next measured whether bodily self representation correspondingly changed incorporate new face experiment participants rated morphs newly associated according similar self performing perceptual matching task changes conceptual self effect bodily self representation results suggest modulatory links aspects mental self representation focused nonsocial self unidirectional flow bottom manner
mertz glacier tongue mgt east antarctica studied since early expeditions produced maps using ground ship based observations followed later vertical oblique aerial photography aircraft modern era extensive digital satellite imagery available also supplemented resurrection scanning historic declassified film based satellite images much mgt became detached drifted away following collision iceberg february similar sequence extension detachment cycle must occurred time mawson observations available information position shape appearance mgt examined attempt comprehensively study past present possible future motion feature tracking cross correlation methods applied suitably detailed image pairs accurately measure mgt advance velocity derived mean rate accompanying ice front loss rate similar simple model mgt exhibits similar year quasi periodic cycle rebirth growth demise affect volume bottom water produced nearby polynya evidence cyclic oceanographic change recently reported regional sediment data somewhat speculatively model suggests date similar previous mgt break around similar next mgt primed brealc every similar years precise date governed unpredictable external events collisions large icebergs cycles probably occurred many thousands years elsevier inc rights reserved
methods switched capacitor noise analysis published date fall two groups one group contains methods suitable analysis hand easily applicable circuits group contains methods applicable circuits require matrix manipulations computer algebra tool paper show universally applicable hand analysis method main reason noise analysis difficult noise sampled many different capacitors sampled spectrum aliased core idea making analysis hand possible use intuitive rather algebraic method derive continuous time noise spectra different phases method combines charge equation analysis discrete time aspects signal flow graph analysis continuous time aspects circuit show tutorial style apply demonstrate useful getting insight circuits deriving simplified expressions getting good correspondence behavioural simulations using spectrerf
mhd homogeneous heterogeneous reaction nanofluid flow due permeable shrinking surface studied bvpc program matlab used obtain numerical solutions several values parameters suction parameter magnetic parameter nanoparticle volume fraction heterogeneous reaction homogeneous reaction rates results show dual solutions exist magnetic parameter nanoparticle volume fraction widen range solution domain suction parameter magnetic parameter nanoparticle volume fraction cause skin friction coefficient increase velocity decrease concentration increases nanoparticle volume fraction increases decrease homogeneous reaction rate heterogeneous reaction rate increase
microbes colonizing infant gastrointestinal tract implicated later life disease states allergies obesity recently medical research community begun realize early colonization events may impactful future health presence key taxa required proper immune metabolic development however studies date focused bacterial colonization events left fungi clinically important sub population microbiota number recent findings indicate importance host associated fungi mycobiota adult infant disease states including acute infections allergies metabolism making characterization early human mycobiota important frontier medical research review summarizes current state knowledge focus factors influencing infant mycobiota development associations early fungal exposures health outcomes also propose next steps infant fungal mycobiome research including longitudinal studies mother infant pairs monitoring long term health outcomes exploration bacterium fungus interactions improved methods databases mycobiome quantitation
microglia mediated neuroinflammation plays important role pathogenesis alzheimer disease advanced glycation end products ages receptor advanced glycation end products rage rho rho kinase rock involved development non specific inflammation however reports effects neuroinflammation explored mechanism ages rage rho rock pathway underlying non specific inflammation microglial polarization cells ages could activate rock pathway concentration dependent manner rock inhibitor fasudil rage specific blacker fps significantly inhibited ages mediated activation cells induction reactive oxygen species ros fps fasudil exerted anti inflammatory effects downregulating inducible nitric oxide synthase inos cyclooxygenase cox nlrp nuclear translocation nuclear factor kappa addition ages induced marker marker phenotype cells fasudil fps led decreased increased phenotype together results indicate ages rage rho rock pathway cells could intensify non specific inflammation provide novel strategies development anti drugs elsevier rights reserved
mindful reappraisal hypothesis mindfulness meaning theory garland psychol inquiry psychol inquiry proposes mindfulness generates eudaimonic well promoting positive reappraisal positive psychological process stressful events construed benign meaningful growth promoting test hypothesis examined prospective relations state mindfulness positive reappraisal community sample participating mindfulness based intervention mbi seven weekly time points throughout mbi participants engaged min mindfulness meditation exercise home completed measure degree state mindfulness experienced meditation well measure use positive reappraisal previous week support mindful reappraisal hypothesis mindfulness meaning theory found latent growth curve multivariate autoregressive latent trajectory models increases trajectory state mindfulness experienced meditation significantly robustly associated frequent use positive reappraisal course participation week long mbi thus mindfulness reappraisal may reciprocally enhance one another interdependent components positive feedback loop whose structure might best described upward spiral
misinformation effect defined impairment memory past events due exposure misleading information loftus people may susceptible misinformation effect others may also depend response distressing event purpose current study investigate several key factors may contribute misinformation susceptibility distressing events namely posttraumatic stress disorder symptoms avoidance intrusions dissociation participants watched either neutral trauma film rated level distress completed measures trait state dissociation participants returned week later misinformation introduced via eyewitness statement free recall assessed findings indicated dissociation related higher distress ratings following film related acceptance misinformation however avoidance scores related increased recall misinformation items reported experiences intrusions related greater accuracy results discussed light paradoxical negative emotion hypothesis
mixture heptane isobutanol presents minimum maximum boiling azeotropes pressure changes two different pressure swing distillation psd processes available mixture pressure low pressure column set atmospheric steady states two available psds optimized minimizing total annual cost tac following sequential iterative optimization procedure basis steady state results dynamic control two available psds comparison presented conventional psd cpsd economical less controllable unusual psd upsd seldom studied published literature two different psd processes considered separation type mixture according advantages elsevier ltd rights reserved
modeling analysis electromechanically coupled typical aeroelastic section shape memory alloy springs wind energy harvesting addressed paper airfoil two degrees freedom namely pitch plunge considered piezoelectric coupling added plunge degree freedom load resistance assumed electrical domain problem order estimate electrical power output shape memory alloy coil springs modeled pitch degree freedom typical section nickel titanium alloy exhibits pseudoelasticity room temperature assumed constitutive model shape memory alloy based classical phenomenological models unsteady aerodynamic loads obtained jones approximation wagner indicial function resulting nonlinear electroaeroelastic model cast state space representation solved runge kutta method effects preload values shape memory springs resistive power generation aeroelastic behavior wind energy harvester investigated flutter boundary post flutter regime nonlinear kinetics austenite martensite phase transformation changes typical linear flutter behavior stable limit cycle oscillations range airflow speeds nonlinear aeroelastic behavior introduced hysteretic behavior sma springs provides important source persistent electrical power
modified discrete cosine transform mdct modified discrete sine transform mdst employed subband transform coding schemes analysis synthesis filter banks based concept time domain aliasing cancellation tdac princen bradley johnson defined two types mdct specifically evenly stacked oddly stacked analysis synthesis systems mdct basic processing component international audio coding standards commercial products high quality audio compression almost existing audio coding systems used complex valued real valued fft algorithms dct dst type dct dst fast mdct computation new fast efficient algorithm unified forward inverse mdct mdst computation oddly stacked system proposed based dct dst types iii dct dst dct iii dst iii real arithmetic used corresponding generalized signal flow graph regular structurally simple enables compute mdct mdst inverses general divisible length data sequence consequently new fast algorithm adopted mdct computation current audio coding standards mpeg family mpeg mpeg mpeg advanced audio coding mpeg audio commercial products proprietary audio coding algorithms sony minidisc atrac atrac sdds digital audio coding systems perceptual audio coder pac lucent technologies pac enhanced pac multichannel pac dolby labs digital audio compression algorithm besides new fast algorithm interesting properties provides efficient implementation forward inverse mdct computation layer iii mpeg audio coding length data blocks equal especially algorithm shown proposed new mdct mdst algorithm existing fast algorithms computational architectures discrete sinusoidal transforms computation real data sequences dct dst generalized discrete fourier transform type dft generalized discrete hartley transform type dht used fast alternate simultaneous line mdct mdst computation simple pre post processing data sequences elsevier science rights reserved
modified zakharov kuznetsov mzk equation electrical transmission line investigated paper different expressions parameters mzk equation given means hirota method bilinear forms soliton solutions mzk equation obtained linear stability analysis yields instability condition soliton solutions find soliton amplitude becomes larger inductance capacitance decrease phase plane analysis conducted mzk equation properties equilibrium points investigate perturbed mzk equation proposed external periodic force considered weak developed chaotic motions observed results indicate two chaotic motions manipulated certain relation absolute values nonlinear terms perturbed one also find chaotic motions weakened absolute values decreased elsevier ltd rights reserved
moisturizing potentially protective properties organic osmolyte betaine trimethylglycine made attractive component skin care products wide use despite lack comprehensive studies addressing specific effects skin led characterize molecular targets betaine keratinocytes explore whether modifies effects acute uvb exposure genome wide expression analysis performed organotypic cultures rat epidermal keratinocytes treated either betaine uvb combination results verified qrt pcr western blotting immunohistochemistry additionally cell proliferation differentiation analyzed among genes influenced betaine differentiation marker keratin showed highest upregulation also confirmed protein level expression egr transcription factor purkinje cell protein regulator calmodulin metabolism also increased downregulated genes included several ion channel components fxyd bioinformatics analyses suggest genes modulated betaine involved dna replication might counteract induced processes include many targets transcription factors associated cell proliferation differentiation results indicate betaine controls unique gene expression pathways keratinocytes including involved differentiation elsevier ltd rights reserved
molecules pathways gut brain axis represent new targets developing methods diagnose treat psychiatric disorders manipulation gut microbiome probiotics may therapeutic strategy potential relieve gastrointestinal comorbidities improve psychiatric symptoms candida albicans saccharomyces cerevisiae commensal yeast species imbalanced unhealthy human microbiome fungal exposures previously found elevated schizophrenia longitudinal double blind placebo controlled pilot investigation outpatients schizophrenia examined impact probiotic treatment yeast antibody levels relationship treatment antibody levels bowel discomfort psychiatric symptoms found probiotic treatment significantly reduced albicans antibodies week study period males females antibody levels cerevisiae altered either treatment group highest levels bowel discomfort time occurred albicans seropositive males receiving placebo observed trends towards improvement positive psychiatric symptoms males treated probiotics seronegative albicans results pilot study hint association albicans seropositivity worse positive psychiatric symptoms confirmed larger cohort males schizophrenia conclusion administration probiotics may help normalize albicans antibody levels albicans associated gut discomfort many male individuals studies larger sample sizes warranted address role probiotics correcting albicans associated psychiatric symptoms elsevier inc rights reserved
montage image mosaic engine designed scalable toolkit written performance portability across nix platforms assembles fits images mosaics code freely available widely used astronomy communities research product generation developing next generation cyber infrastructure recently begun finding applicability field visualization development come toolkit design allows easy integration scalable systems process data subsequent visualization browser client toolkit includes visualization tool suitable automation integration python mviewer creates single command complex multi color images overlaid coordinate displays labels observation footprints includes adaptive image histogram equalization method preserves structure stretched image dynamic range montage toolkit contains functionality originally developed support creation management mosaics also offers value visualization background rectification algorithm reveals faint structure image tools creating cutout downsampled versions large images version montage offers support visualizing data written healpix sky tessellation scheme functionality processing organizing images comply toast sky tessellation scheme required consumption world wide telescope wwt four online tutorials allow readers reproduce extend visualizations presented paper
important environmental processes riparian zones release carbon nitrogen phosphorus various organic compounds extracellular enzymes soil microorganisms involved bio geochemical cycling organic matter nutrients may important regulating water quality objectives present study determine whether activities soil enzymes affected different inundation periods riparian zone identify major factors influence soil enzyme activity subjected three study plots different inundation conditions long inundation moderate inundation rare inundation within transects perpendicular river flow three sites weijiadu lijiaocun daxu lijiang guilin city china soil physicochemical properties dissolved nutrient composition soil enzyme activities analyzed activity acid phosphatase alkaline phosphatase arylsulfatase significantly increased inundation frequency decreased whereas activity glucosidase beta acetylglucosaminidase glycine aminopeptidase leucine aminopeptidase dehydrogenase significantly higher study plots received long inundation subjected moderate rare inundation linear regression indicated hydrolase dehydrogenase activities affected soil clay content soil organic matter soil water content among factors limited activity acid phosphatase leucine aminopeptidase glycine aminopeptidase polyphenol oxidase activity constrained soil water content available potassium promoted study demonstrated imposing longer inundation periods increase soil enzyme activities maintain microbial activity minimize water pollution important reduce high loads elsevier rights reserved
multifunctional intelligent information sensor system developed using nanostructured multilayer thickfilm structures based spinel type nimno cumnomncoo manganites magnesium aluminate mgo alo technological features nanostructured sensor preparation represented diagram system proposed system microprocessor signal processing shown successfully applied integrated temperature humidity environment monitoring control
multiple imputation technique proven useful tool missing data analysis propose markov chain monte carlo method conduct multiple imputation incomplete correlated ordinal data using multivariate probit model conduct thorough simulation study compare performance proposed method two available imputation methods multivariate normal based chain equation methods various missing data scenarios illustration present application using data smoking cessation treatment study low income community corrections smokers
myotendinous junction mtj specialized structure musculotendinous system force transmitted muscle tendon animal models shown mtj takes form tendon finger like processes merging muscle tissue human mtj largely unknown never described three dimensions aim study describe ultrastructure human mtj render reconstructions fourteen subjects age years isolated injury anterior cruciate ligament acl scheduled reconstruction semitendinosus gracilis graft included semitendinosus gracilis tendons stripped grafts acl reconstruction mtj isolated grafts prepared transmission electron microscopy tem focused ion beam scanning electron microscopy possible isolate recognizable mtj tissue patients tem images displayed similarities observations animals sarcolemmal evaginations observed finger like processes tendon endomysium surrounding muscle fibers myofilaments extending final line muscle fiber merging tendon tissue reconstruction revealed tendon made ridge like protrusions interdigitiated groove like indentations muscle cell
national institute occupational safety health expanded research program investigating agricultural injuries data supplementary data system sds maintained bureau labor statistics department labor indicate injuries back lower extremities agricultural workers quite common injury data sds examined agricultural employees years states consistently provided records year year period total injuries reported sds agricultural industry groups included study classified sprains strains analysis data indicate workers industries within major groupings crop production agricultural services increased potential sustaining sprain strain injury
nation fight fat reduced obesity worrying effects mental health researchers raised possibility intense pressures lose weight heightened risks developing eating disorders especially among young medical anthropology help connect dots war fat disordered eating identifying specific mechanisms pathways contextual forces may lie beyond scope biomedical psychiatric research article develops biocitizenship approach focuses pathologization heaviness necessity thin fit body belonging category worthy citizen work pervasive fat talk defining belong ethnographic narratives california illuminate dynamics individual lives lending powerful support idea battle fat worsening disordered eating eating disorders among vulnerable young people
nationwide statistical analysis disease classical myeloproliferative neoplasm mpn korea reported yet end analyzed incidence rates survival rates treatment pattern polycythemia vera primary myelofibrosis essential thrombocythemia using korea national cancer incidence database kncidb health insurance review assessment service hira database total new cases mpn reported kncidb common followed crude incidence rates increased period reaching per respectively five year relative survival rate mpn patients lowest relative survival rate prevalence disease estimated hira data also increased study period notably found prevalent prescription rate hydroxyurea phlebotomy patients remained constant period prescription rate hydroxyurea higher patients age years first korean nationwide statistics mpn using central registry data set data utilized compare korean mpn status international data guidelines
need find better products efficient technique help removing toxic pathogens water help reduction water pollution fastest effective way low cost could help worlds pollution problem past chemicals used water purification cleaning still much use chemical chlorine ozone etc used however research shown chemical products often given reactions various components natural water indicating different types disinfectant byproducts obtained maybe known carcinogenic meanwhile using antibiotics conventional method become less effective resistant strains antibiotics therefore quest design robust bio detection strategy necessary identification precipitation method best method considered employed preparation magnetic nanoparticles using one step reaction process functional group probing synthesized magnetic nanoparticle well morphological analysis particle size determination achieved fourier transform infrared spectroscopy ftir atomic force microscope afm zeta sizer respectively properly coated right stable polymer use magnetic chitosan nanoparticle become widely known helpful pathogen detection aim resolving world pollution problem
negative affects violent occupationfear threat humiliationquell hope setting limits potentials political agency article documents corporeality occupation hebron evoking body materially contingent explore agential capacities within delimiting affects violent sensorium drawing fieldwork palestinian activists engaged providing political tours hebron argue reappropriating violent affects occupation form activism demonstrates agency resists political depression theoretically argue hand empirical account autonomy affect giving rise critical hope amid sensorium fear research presented therefore contributes addressing key question resistance palestine beyond feara predominant affective register contemporary politicsmight harnessed towards renewed political agency resistance oppression
neural basis autism spectrum disorder asd yet understood asd marked social deficits strongly associated cerebellar abnormalities studied organization cerebellar connectivity temporoparietal junction tpj area plays crucial role social cognition applied localized independent component analysis resting state fmri data autistic neurotypical adolescents yield unbiased parcellation bilateral tpj independent components ics comparison neurotypical autistic adolescents showed organization tpj significantly altered asd second used time courses tpj ics spatially unbiased seeds functional connectivity analysis applied voxels within cerebellum found cerebellum contained fine grained lateralized map tpj connectivity tpj subdivisions cerebellar zones showed one striking difference asd right dorsal tpj showed markedly less connectivity left crus disturbed cerebellar input key region cognition multimodal integration may contribute social deficits asd findings might also suggest right tpj left crus potential targets noninvasive brain stimulation therapies
neural extracellular matrix ecm plays important role regulation perisomatic gabaergic inhibition synaptic plasticity hippocampus cortex decreased labeling perineuronal nets form ecm predominantly associated parvalbumin expressing interneurons brain observed post mortem studies schizophrenia patients specifically brain areas prefrontal cortex entorhinal cortex amygdala moreover glial ecm form dandelion clock like structures reported altered schizophrenia patients verified whether similar abnormalities neural ecm reproduced rat model schizophrenia animals received sub chronic administration ketamine reproduce aspects disease related disrupted signaling methyld aspartate receptors study focused two schizophrenia related brain areas namely medial prefrontal cortex mpfc hippocampus semi quantitative immunohistochemistry performed evaluate investigate ecm expression using wisteria floribunda agglutinin wfa antibody labeling distinct chondroitin sulfate epitopes enriched perineuronal nets glial ecm respectively analysis revealed ketaminetreated rats exhibit reduced number wfa labeled perineuronal nets decreased intensity parvalbumin fluorescence mpfc interneurons somata moreover found increased expression immunoreactive form ecm importantly loss perineuronal nets revealed mpfc detected hippocampus suggesting regional specificity ecm alterations data open avenue investigations functional importance ecm abnormalities schizophrenia well search treatments compensation ibro published elsevier ltd rights reserved
new academic center achieved leed platinum rating first cornell core campus obligation meet university green building criteria given design largely influenced historic preservation interest maintaining views historic quadrangle valuable campus green space drivers led comprehensive design process alignment university long term goals overall campus redevelopment first phase initiative grade classroom addition provides new space law school programs exceptionally energy efficient building concurrent environmental benefits including preservation open space enhanced storm water management addition thoughtful addition landmark building project emphasized use existing local building materials
newly proposed source inverter proven literature exhibit steady state voltage buck boost capabilities using unique impedance network coupled power source converter circuit paper presents transient modeling analysis voltage type source inverter aspects found challenging need carefully investigated attempting design advanced control algorithms controlling source inverter detailed analysis paper identifies several phenomena sides inverter would result inverter non minimum phase transient response side phenomenon associated source impedance network shown small signal signal flow graph analyses right half plane zero control output transfer function also side phenomenon shown space vector analysis depend time intervals inverter states used reconstructing desired inverter output voltage based vectorial analysis method improving inverter transient response also presented last simulation results obtained using switching functional model experimental results obtained using laboratory prototype presented validating described theoretical concepts
north western part bangladesh especially barind region considered drought prone area objective paper find adaptation measures practised farmers cope climate change agricultural drought two drought prone villages north western bangladesh primary data study collected structured questionnaire survey conducted households selected simple random sampling present study finds agriculture area recurrently disrupted frequent drought events moreover climate change increase frequency magnitude extreme drought events region paper identifies impacts drought agriculture difficulties irrigation disruption cropping pattern depletion ground water table problem fish cultivation hand analyses unveil respondents practised range adjustment strategies combat adverse impacts drought adoptions drought tolerant crop varieties rainwater harvesting mango jujube intercropping rice kitchen gardening weed control reducing water loss constructing water control structures irrigation cultivation fast growing fish species therefore present study recommends proper drought early warning system reserving surface water managing supplemental irrigation tree plantation excavation canals traditional ponds credit support farmers preparedness awareness rising ensure future sustainable agricultural development study areas
novel temperature responsive poly cholesteryl methacylate pchma coatings derived renewable sources synthesized characterized temperature induced changes wettability accompanied surface roughness modifications traced afm topographies recorded temperatures increasing degrees showed slight noticeable increase calculated root mean square rms roughness factor suggesting horizontal rearrangement structure pchma coatings another structural reordering observed degrees temperature range recorded topography changed noticeably smooth structured rough returned eventually relatively smooth addition temperature transitions pchma molecules revealed dsc measurements biocompatibility pchma grafted coatings shown cultures granulosa cells non malignant bladder cancer cell hcv line culture elsevier rights reserved
protease inhibitor demonstrated antiviral activity monotherapy study combination daas treatment chronic hepatitis virus hcv infection resistance profile investigated phase monotherapy study patients hcv genotype infection resistance associated substitutions rass positions observed baseline population sequencing cutoff patients enrolled study however ras detected patients baseline patients received investigational protease inhibitor bid bid three days rass observed post treatment respectively selected patients post treatment mean maximal viral load response log hcv rna bid cohort patients rass detected day mutations longer detectable population sequencing day one patient mutation persist week phenotypic analyses showed substitutions significantly reduced susceptibility conclusion rass rapidly selected majority patients receiving monotherapy despite undetectable levels baseline substitutions identified patients confer reduced susceptibility pis vitro published elsevier
number decease due cardiovascular disease cvd low middle income countries become major concern clinical standpoint electrocardiogram useful mechanism diagnose cardiac diseases therefore electrocardiogram based machine design taken consideration create framework building simple low cost microcontroller based ecg monitoring system however machines current research high price bulky shape deprives people remote area get benefit therefore paper tries design smart economical diagnosis system maintain reliable diagnosis better portability system implemented instrumentation amplifier high common mode rejection ration right leg circuit remove noise main digital analog filtering system optimized signal removing baseline wandering power frequency noise communication hardware software interfaced usb port using microcontroller implementation system shows greater benefits domestic health monitoring rural area medical camp
object modeling technique generally used object oriented software development technique comprises object dynamic functional models provide three corresponding views graphically express diverse aspects software systems paper adds security engineering object oriented model driven software development real life web applications paper use mining patterns web applications research paper proposes unified modeling language based secure software maintenance procedure proposed method applied maintaining large scale software product real life product line products modeling implement run web application spf based trusted operating systems reverse engineering become main concern software development industry complete size much difficulty difficulty needs tackled since software systems question significant importance owners maintainers secure designing web applications paper propose system security performance model trusted operating system engineering implementation process web applications paper proposes model driven roundtrip engineering approach
objective examine prevalence health care costs associated asthma epilepsy hypertension food allergies diabetes children aged years prevalence calculated using medical expenditure panel survey meps data population based nationally representative sample using meps two part models estimated cost condition children controlling sociodemographic categories prevalence rates varied race ethnicity across conditions females higher prevalence chronic conditions except epilepsy additional annually spent medical expenses children aged years asthma diabetes epilepsy compared children without conditions first study examine costs prevalence chronic health conditions children adolescents using single data set understanding odds condition sociodemographic categories highlights disparities potentially inform school nurses best allocation resources serve students
objective explore engaged scholarship could mean construction management research facilitating interactions practice theory aims develop knowledge advances science practice engagement scholars practice three types discussed practice research design research action research three kinds explained different knowledge action relations action theories knowledge action design research knowledge action action research knowledge action relevance three types facilitating interactions practice theory clarified elaborating research programme adoption information communications technology ict construction projects first based grounded theory model developed understand explain individuals organizations using ict intended way second based model expert interviews solutions designed potential barriers successful use ict construction projects third interventions construction projects based solutions presented argued different kinds presuppose needed facilitate interactions practice theory construction management research
objective present study evaluate effectiveness two year intervention program promote emotional intelligence school participants primary school pupils years old study evaluated effects intervention using pre post experimental design control group four evaluation moments assessed questionnaire bar parker adapted spanish ferrandiz hernandez bermejo ferrando sainz results showed effectiveness intervention highlighting increase dimensions bar model intrapersonal interpersonal stress management adaptability general mood findings suggest improved results discussed recommendations made future implementation elsevier ltd rights reserved
objective study analyze impact tnf antagonists tnfa total cholesterol triglycerides ankylosing spondylitis psoriatic arthritis psa single centre observational study psa patients differences triglyceride total cholesterol levels frequency hypertriglyceridemia hypercholesterolemia months analysed patients treated treated tnfa general estimation equations linear regression analysis used investigate associations disease activity lipid levels identify predictors change one hundred fifty seven patients treated treated tnfa included study transient increase cholesterol level baseline months tnfa treated patients statistically significant effect persistent percentages hypertriglyceridemia hypercholesterolemia baseline significantly higher treated tnfa treated patients respectively inverse associations changes cholesterol level bath ankylosing spondylitis disease activity index crp disease activity score joints found whole group psa patients treated tnfa mild transient changes cholesterol triglyceride levels associated changes disease activity
objective paper deconstruct dualistic concept aggressor executioner offended victim context domestic violence thus focuses change reprimand perspective pedagogical one concerning men perpetrate violence way ensuring greater effectiveness public policies women safety violence prevention addition violence women public health problem need highlighted well stereotypical view gender roles demonstrate problem society connivance aggressive behaviors women difficulty recognizing violence furthermore intended support understanding implementation education reflection programs male aggressors must become priority state lato sensu possibility prescribed law
objective paper demonstrate integration mof thin film electrostatically actuated microstructures realize switch triggered gas sensing algorithm based amplitude tracking devices based nonlinear response micromachined clamped clamped beams microbeams coated metal organic framework mof namely hkust achieve high sensitivity softening hardening nonlinear behaviors microbeams exploited demonstrate ideas gas sensing amplitude based tracking algorithm developed quantify captured quantity gas mems switch triggered gas using nonlinear response microbeam demonstrated noise analysis conducted shows switch high stability thermal noise proposed switch promising delivering binary sensing information also used directly activate useful functionalities alarming
objective paper develop analytical optimal design tool determine megawatt scale yokelss segmented armature yasa machine design fulfills application requirements constraints analytical tool considers electromagnetic structural designs different designs provide similar performance emerged analytical process design reference map graphically shows relationships tradeoffs objective function introduced multicriteria optimization process applied determine design optimum optimization process design objectives considered study minimize outer diameter minimize structural mass machine minimize copper iron losses minimize active materials cost three variables considered calculating objective functions air gap flux density ratio outer inner machine diameter current loading optimization method uses pseudoweight vector provide flexibility prioritize one objective functions dependant specific application requirements
objective study analyze optimize solar assisted gas turbine system parabolic trough collectors used order supply part demanded heat input reducing natural gas consumption leading environmental friendly system emphasis given pressure losses collector field loop reduce pressure level turbine inlet leading lower electricity production first part study gas turbine collector field investigated separately second part solar assisted gas turbine investigated parametrically optimized optimization part multi objective optimization performed setting goals minimization collector area fuel consumption inversed electricity production final results proved collector modules lead natural gas consumption electricity production equal mwel optimum solution leads fuel savings penalty produced electricity system analyzed steady state conditions engineering equator solver ees elsevier ltd
objective study assess pain function morbidity patients undergoing synovectomy primary total knee arthroplasty tka osteoarthritis meta analysis included randomized controlled trials comparing tka without synovectomy completed primary outcome postoperative knee pain secondary outcomes included performance perioperative complications validated functional scores operation length hospitalization length literature search produced unique references randomized controlled trials selected inclusion total patients knees included average age years follow intervals studies ranged weeks months included studies ofmoderate high quality evidence low risk bias significant difference two groups regard postoperative pain knee society score postoperative range motion postoperative blood loss significantly lower synovium retaining tka group confidence interval based results currently evidence support use synovectomy tka primary provides clinical benefit increases postoperative blood loss
objective study evaluate relationship social cognition cognitive impairment persons multiple sclerosis pwms prospective study conducted pwms relapsing remitting rrms secondary progressive spms primary progressive ppms healthy subjects subjects assessed bordeaux social cognition evaluation protocol pecs facial emotion recognition theory mind emotional awareness cognitive affective alexithymia large neuropsychological battery questionnaires depression anxiety pwms impaired least one test proportion pwms least two impaired tests similar three phenotypes mean scores differed significantly pwms reading mind eyes test test theory mind tom anova analyses showed effect phenotype emotional awareness scores lower scores ppms compared rrms tom performance significantly correlated executive functions working memory episodic memory scores impairment found phenotypes prominent cognitively impaired patients executive functions working episodic memory performance accounts approximately tom performance emotional awareness impaired progressive
objective study investigate use alternative working pair solar absorption cooling system licl new examined pair compared energetically exegetically conventional pair libr usual air conditioning applications simplest solar cooling system analyzed order focus comparison working fluids specifically flat plate collectors coupled storage tank feed single effect absorption chiller produces cooling degrees two pairs examined parametrically various heat source temperature levels three ambient temperature levels degrees degrees degrees minimization collecting area means maximum exergetic efficiency optimization goal every case final results show licl pair performs better cases giving greater exergetic efficiency specifically lower collecting area required cover demanded cooling load working pair another interesting result optimum heat source temperature licl roughly lower respective libr system analyzed steady state commercial software engineering equator solver ees elsevier ltd rights reserved
objective study determine pattern traumatic lens dislocations presenting institute may help develop preventive strategies number cases traumatic lens dislocations presented department ophthalmology chandka medical college larkana pakistan january june including males females cause trauma wood plant impalement cases cracker blast cases fall ground cases penetrating injuries needle scissors knife cases road traffic accidents cases sports injuries cricket ball guile danda cases firearm injuries cases fist hitting cases lens dislocated posteriorly cases anteriorly cases inferiorly cases medially cases laterally cases superiorly cases single case lenticele seen
objective study identify predictors sustained psychotic symptoms methamphetamine abuse course months patterns substance use depressive symptoms family history psychosis antisocial personality disorder trauma history total individuals abuse psychotic symptoms seeking psychiatric services assessed baseline monthly symptoms substance use months trajectory analyses revealed two trajectories individuals positive symptoms one group presenting persistent psychotic symptoms sample persistent psychosis significantly older severe psychotic symptoms misused years antisocial personality traits sustained depressive symptoms strongest predictors belonging persistent psychosis group via logistic regressions severe psychotic symptoms longer use sustained depressive symptoms results highlight important comorbidities especially regarding depressive symptoms persistent psychosis individuals seeking psychiatric help abuse study also highlights importance identifying people persistent psychosis within users facilitate rapid effective treatment occurring psychotic disorder
objective study obtain material composite antifungal properties dentures used alternative protocol denture stomatitis treatment prevention denture stomatitis still clinical problem patients particularly vulnerable disease composites pmma doped zno nps weight concentrations pmma sprayed solvothermal hydrothermal zno nps tested following investigations newly formed biomaterials undertaken influence candida albicans solution biofilm staining xtt analysis quantitative analysis adhered albicans studies evidenced antifungal activity nanocomposites pmma onps efficacy sputtering zinc oxide nanoparticles pmma study biofilm deposition surface showed antifungal properties increase increasing concentration zno nps xtt assay conjunction testing turbidity solutions may indicate mechanism zno nps exert effect increased induction antioxidative stress microorganism cells denture base made aforesaid materials may play preventive role patients susceptible fungal infections based results obtained modified treatment stomatitis type newton classification complicated fungal infection proposed elsevier rights reserved
objective study provide fundamental parameters utilization bamboo scrimber building structure field green building material static tensile compressive tests conducted bamboo scrimber specimens compressive tests specimens tensile tests normal lognormal distributions selected fit experimental data design values calculated according chinese allowable stress design method astm results showed tensile strength uts compressive strength parallel fiber bamboo scrimber significantly higher wood bamboo based composite materials kolmogorov smirnov chi squared test results indicated lognormal distribution good fit uts except fitting result uts chi squared test calculated design values uts using astm higher compared found using chinese allowable stress design method
objective work develop evaluate classifier differentiating probable alzheimer disease parkinson disease dementia pdd dementia lewy bodies dlb frontotemporal dementia behavioral variant bvftd based quantitative electroencephalography qeeg compared qeeg features dementia patients patients probable patients pdd probable dlb dlbpd patients bvftd support vector machine classifiers trained distinguish among three groups features turned significantly different dlbpd versus bvftd bvftd versus dlbpd using leave one cross validation classification achieved accuracy sensitivity specificity using qeeg features granger causality ratio theta beta band powers results indicate classifiers trained selected qeeg features provide valuable input distinguishing among dlb pdd bvftd patients study patients misclassifications occurred therefore studies investigate potential method applied group level also diagnostic support individual subjects
objective work study reduction capsaicin toxicity encapsulation liposomes capsaicin extracted peppers characterized high performance liquid chromatography hplc determined zeta potential polydispersivity index pdi vesicle size liposomes wistar rats submitted intravesical instillation liposomes lip capsaicin cap liposomes capsaicin caplip hours bladders removed histological analysis vesicle size ranged pdi smaller zeta potential around vesicles maintained stability day study histological analysis cap group showed intense inflammation almost bladder layers well ulcer formation conversely caplip group showed smooth inflammatory reaction hyperemia conclusion liposomes effectively protected bladder irritative action capsaicin
occurrence alzheimer disease growing cases occurring women declines global function exacerbated reversal day night patterns disturbed sleep wake rhythms excessive daytime sleepiness make managing difficult study authors examined effect duration effect therapeutic light sleep rest activity global function women using mixed methods two group experimental design repeated measures one factor twenty women randomized experimental control conditions blue green dim red light delivered via cap visor morning results qualitative analysis serial interviews family facility caregivers regarding perceived effect light global function presented themes emerged groups respect cognition psychosocial function future studies larger samples using quantitative measures global function warranted verify findings
occurrence thyroid disorders relies nutrition monitoring populations recommended measuring urine standard thyroglobulin serum alternative led assess reliability studies using serum thyroglobulin compared urinary assess nutrition level calculate number participants needed study repeated data sampling individuals year diet supplement use life style factors assessed questionnaires measured thyroglobulin thyroglobulin antibodies serum urine participants thirty three caucasians sixty four inuit living greenland aged years serum thyroglobulin decreased rising excretion kendall tau differ ethnicity variation individuals lower serum thyroglobulin urinary mean individual required urine samples certain urinary excretion within true mean population serum thyroglobulin precision required samples individual ten times samples needed depict deficiency using urinary excretion compared serum thyroglobulin conclusion participants need portray deficiency population using urinary compared serum thyroglobulin ten times samples needed individual adding serum thyroglobulin urinary may inform surveys nutrition allowing subgroup analysis similar reliability
oncogenic roles sphingosine kinase sphk various cancers including thyroid cancer well demonstrated however micrornas mirnas associated oncogenic roles sphk remain largely unknown global gene mirna expression tpc vector tpc sphk cells analyzed using digital gene expression dge analysis small rna seq respectively mirna mrna interactions explored microt cds predicted networks visualized using cytoscape cell invasion migration assessed performing transwell invasion wound healing assays luciferase reporter immunoblot assays used evaluate targeting fibronectin mir study found overexpression sphk differentially regulates expression mirnas mrnas papillary thyroid cancer ptc tpc cells combining bioinformatics predictions mrna targets dge data mrna expression allowed identify mrna targets deregulated mirnas direct interaction mir mediates pro invasive role sphk ptc cells experimentally validated results demonstrated sphk overexpression drives regulatory network governing mirna mrna expression ptc cells also demonstrated roles played mir mediating oncogenic function sphk enhanced understanding etiology ptc
line measurement high power igbt collector current important hierarchical control short circuit overcurrent protection driver sensorless control converter conventional line measurement methods igbt collector current suitable engineering measurement due large size high cost low efficiency sensors current transformers dividers etc based gate driver paper proposed current measuring circuit igbt collector current circuit used conduct non intervention line measurement igbt collector current detecting voltage drop igbt power emitter auxiliary emitter terminals theoretical analysis verifies feasibility circuit circuit adopts operational amplifier impedance isolation prevent measuring circuit affecting dynamic performance igbt due using scheme integration first amplification afterwards difficult problem achieving high accuracy transient state state measurement voltage terminals igbt power emitter auxiliary emitter solved impossible conventional detector basis adoption two stage operational amplifier better meet requirements high bandwidth measurement conditions small signal large gain finally various experiments carried conditions several typical loads resistance inductance load resistance load inductance load different igbt junction temperatures soft short circuits hard short circuits line measurement igbt collector current aided capacitor voltage integration result voltage uee results show proposed method measuring igbt collector current feasible effective
indication testosterone administration older men testosterone replacement therapy male hypogonadism compared young hypogonadal men diagnosis management male hypogonadism older men challenging clinical manifestations androgen deficiency low testosterone levels may caused modified comorbid illnesses occur medications taken frequently older men resulting greater likelihood overdiagnosis hypogonadism subsequent inappropriate use inadequate response testosterone treatment important use systematic holistic approach diagnosis management older men hypogonadism
operational amplifiers versatile significant modules field electronic circuits two stage amp multistage amplifier widely useful chip applications proposed circuit two stage operational amplifier designed using differential architecture implemented cmos technology circuit gives best results high gain low power consumption technology
optimum word length selection arithmetic circuits vlsi implementation crucial optimizing design area power paper proposes scheme word length optimization wlo using system level parameters dynamic range snr scaled fixed point sfxp representation discussed advantages fixed point floating point dynamic range noise aspects chosen representation simulated using matlab results show snr degradation signals snr bit adc output represented sfxp representation illustrate suitability proposed wlo scheme practical signal conditions multiply accumulate mac unit realized sfxp representation simulation synthesis studies power saving observed xilinx spartan fpgas comparison conventional mac implementation algorithm high level synthesis hls mac units signal flow graph sfg proposed sfxp representation presented
oregon institute technology oit portland center offering manufacturing engineering technology mfget mechanical engineering technology met undergraduate programs students around greater portland metropolitan area past ten years master degree manufacturing engineering technology mmfget also offered programs extensions programs offered oit main campus klamath falls portland campus programs designed specifically cater students employed full time industry paper discusses engineering technology programs direct application training local company full time employees become engineers managers employees associate degrees years experience respective companies discussion engineering related hands work experience understanding engineering principles applications presented effectiveness special instruction techniques custom developed students limited time availability maintaining abet accreditations also discussed discussion oriented learning teaching models impact adding dimensions instructional models industry experienced students mind emphasized case studies presented show improvement student engagement curiosity application new knowledge actual day day work environment problems advantages disadvantages night school discussed
original free swinging piston engine oscillating rotating generator distinguishes compactness minimum frictional losses full balanced mechanical system possibility four stroke operation engine possibility multifuel operation engine optimal magnetic circuit electrical generator etc engine optimally operate whole range output power enables improve electrical system hybrid vehicle usage supercapacitors optimised energy flows way competitive hybrid electric vehicle created
ovarian reserve represents stock quiescent primordial follicles ovary gradually depleted woman reproductive lifespan resulting menopause mullerian inhibiting substanc mis anti mullian horo amh whic produced granulosa cells growing follicles proposed negative regulator primordial follicle activation show long term parenteral administration superphysiological doses mis using either adeno associated virus serotype aav gene therapy vector recombinant protein resulted complete arrest folliculogenesis mice ovaries mis treated mice smaller controls contain growing follicles retained normal ovarian reserve mice treated aav mis paired male breeders exhibited complete permanent contraception entire reproductive lifespan disrupted vaginal cycling hypergonadotropic hypogonadism however ovaries aav mis treated mice transplanted orthotopically normal recipient mice treatment protein discontinued folliculogenesis resumed suggesting reversibility one important causes primary ovarian insufficiency chemotherapy induced primordial follicle depletion proposed mediated part increased activation test hypothesis mis could prevent chemotherapy induced overactivation mice given carboplatin doxorubicin cyclophosphamide cotreated aav mis recombinant mis protein vehicle controls found significantly primordial follicles mis treated animals controls thus treatment mis may provide method contraception unique characteristic blocking primordial follicle activation could exploited prevent primary ovarian insufficiency often associated chemotherapy
overall objective present work estimate degradation level old reverse osmosis membranes terms permeability salt rejection along potential reuse ultrafiltration membranes naocl oxidation ppm detailed study old membrane materials deconstruction also resulted recommendations reuse geotextile mouse pad support children drawings protection snake attack aromatic wall familial kitchen alternatives solutions incineration end work old membrane materials recycled
overtopping breakwater energy conversion obrec overtopping type wave energy converter totally embedded traditional rubble mound breakwaters device consists reinforced concrete front reservoir designed aim capturing wave overtopping order produce electricity energy extracted low head turbines using difference water levels reservoir sea water level paper investigates nature magnitude wave loadings exerting various parts structure results improve overall knowledge device behavior completing highlights complementary test campaign carried wave flume vicinanza formulas provided used design first obrec prototype breakwater operation since january naples harbour italy
overwhelming majority vegetable oils extracted using solvent extraction widely used solvent hexane however use ethanol attractive advantages including low toxicity good operational security well obtained biorenewable source study multiple batch solid liquid extraction system successfully employed simulate continuous countercurrent ethanolic extraction rice bran oil results showed extraction process using ethanol solvent feasible facilitated increases temperature number equilibrium stages required rice bran oil extraction theoretically determined shown extraction process using hexane number ideal stages lower number required ethanol used solvent furthermore mathematical expression determining minimum flow solvent depending equilibrium relationship extract raffinate phases developed implemented solvents given potential fire hazard harmful emissions risks using hexane solvent extraction ethanol showed promising alternative conventional extraction completely exhausting solid matrix five stages elsevier ltd rights reserved
palatine rugae specialized structures located fused hard palate however number arrangement direction palatine rugae differ among species since crocodilians evolutionally first animals show fusion palate authors focused structure crocodilian palate surface structure palate alligator mississippiensis postnatal days examined stereomicroscopy scanning electron microscopy addition histological observation made hematoxylin eosin azan staining moreover urea silver nitrate method used nerve staining palate alligator mississippiensis many papilla like small conic shaped projections width height observed although palatine rugae projections distributed whole palate difference density region anterior middle posterior portion hard palate projections consisted keratinized stratified squamous epithelium connective tissue particular many collagen fibers observed connective tissue bundles nerve fibers ran connective tissue toward oral epithelium collagen fibers sparse area fascicle nerve fibers epithelium projections generally known many nerve fibers nerve endings located connective tissue palatine rugae since many nerve fibers connective tissue projections suggested projections may act sensitive organs palatine rugae
paper aims determine day ahead market bidding strategies retailers flexible demands maximize short term profit proposes short term planning framework forecast load dynamic tariffs construct biding curves stochastic programming applied manage uncertainties spot price regulating price consumption behaviors responsiveness dynamic tariffs case study based data sweden carried demonstrates real time selling price affect aggregate load residential consumer group lead load shift toward low price periods optimal bidding curves specific trading periods illustrated comparing bidding strategies different risk factors case study shows risk averse retailer tends adopt strategies larger imbalances benefit lies reduction low profit risk however aversion risk kept certain level larger imbalance may lead quick reduction profit scenarios
paper aims perform comparative analysis regarding testing results achieved experimental model counter rotating wind turbine rated power wind velocity experimental model consisted system two rotors rotate opposite directions one rotor rotating clockwise direction counter clockwise direction one unique electrical generator adds rotation wind rotors ratio two diameters wind rotor slightly larger wind one experimental model provided three phase synchronous electric generator counter rotating armatures power rpm type generator characterized reduced size increased rotational speed losses due movement transmission experiments wind turbine system performed wind tunnel well situ location nearby iasi city romania turbine installed paper focuses investigating operation system controlled test conditions real conditions wind changes velocity direction order determine effect variations wind turbine system tested different wind velocities wind tunnel free air stream situ testing performed also order validate results obtained experimental model counter rotating wind turbine system within wind tunnel noticed good consistency two sets experiments resulting procedure suitable applied designing wind turbine prototype
paper begins definition hard soils soft rocks hssr followed short overview typical stress strain behavior hssr shown spite differences origin type strength materials similar stress strain behaviors observed different materials ranging soils rocks based observed similarity theoretical framework postulated appropriate constitutive model hssr beformulated model includes concepts structure destructurization intrinsic material properties model named brick takes account structure destructurization developed comparison models predictions laboratory results presented
paper concerns development pto power take oft control owc oscillating water column spar buoy wave energy converter owc spar buoy axisymmetric device consisting submerged vertical tail tube open ends rigidly fixed floater moves essentially heave oscillating motion internal free surface relative floater tube set produced incident waves makes air flow novel self rectifying air turbine biradial turbine reduce losses pto system partial load electrical generator rated power twice maximum expected average power conversion buoy adopted control turbine generator set highly energetic sea state conditions experimentally investigated means tests performed pto test rig reported tests hydrodynamics owc spar buoy aerodynamics air turbine numerically simulated real time coupled experimental model turbine electrical generator set hardware loop configuration experimental results allowed dynamic behaviour pto characterized provided validation proposed control algorithms ensure operation within safe limits elsevier ltd rights reserved
paper deals hardware solution study low power active filter bode plotting using daq card experimental platform shows labview graphical programming environment used manual automated testing analysis first order active filter operational amplifier amp hardware platform provide template build real amp circuits better understand together previous one paper developing software simulation demonstrations amp filters principles main contribution paper refers software hardware solution obtaining manual automat bode plotting plotting frequency response curve filters often necessary measure output signal range input frequency hardware experiments allows range test voltages variable frequency input filters response measured displayed analyzed frequency scan range scan rate number test points selected front panel controls another contribution practical tool analysis response filter various input signals sine square triangular wave calculating filter gain depending amplitude measured units peak peak peak roots mean square signal level
paper deals analogue frequency filter synthesis using signal flow graph theory individual forms characteristic equation transfer function denominator described guarantee possibility controlling quality factor independently characteristic cut frequency help active elements design procedure shown design frequency filter working current mode current active elements pca cmi behaviour proposed filter verified simulations orcad program also experimental measurements
paper deals application stochastic differential algebraic equations sdae field time domain simulation hybrid lumped distributed systems randomly varying parameters core method lies theory stochastic differential equations sde considering system responses stochastic processes however due hybrid nature system namely lumped parameter part non differential algebraic parts arise generally solution herein multiconductor transmission lines mtl play role distributed parameter parts hybrid system mtl model designed cascade connection generalized rlcg networks state variable method applied description mtl boundary conditions incorporated modified nodal analysis mna cover arbitrarily complex circuits system responses formed sets stochastic trajectories completed corresponding sample means respective confidence intervals get results weak stochastic backward euler scheme used consistent ito stochastic calculus computer simulations performed matlab language environment
paper describes reforming system converting methanol pure hydrogen system based autothermal reforming reactor operating elevated pressures followed membrane based hydrogen separation high pressure membrane retentate stream combusted expanded turbine generating additional power process simulation illustrates effects system operating parameters performance demonstrates system reforming efficiency similar coupled pem fuel cell electrical generator overall fuel electricity efficiency depending upon efficiency pem fuel cell stack elsevier rights reserved
paper describes effective method determining optimal parameters linear fuzzy pid controller use matlab services referred fuzzy logic toolbox response optimization published elsevier open access article license
paper describes design manufacturability prototype product part manufacturing engineering capstone course product chosen vertically launched unmanned aerial vehicle uav flying eye flying eye autonomous parafoil surveillance platform equipped sensors controllers mechanical components software autonomous uav deployed designed follow predetermined flight path ground design effort prototype device took place three year period collaborative effort aerospace engineering industrial manufacturing engineering departments california polytechnic state university project proved excellent tool project based learning environment focus cal poly hands engineering programs details flying eye project lessons learned course educational experience provided
paper discusses practical problems occurring iso application technical practice technical diagnosticians find frequently zone boundaries proposed standard sensitive adequately changes vibrations operation resulting change technical condition machine principle statistical determination individual operational limits measured overall level rms vibration velocity overall level utilization statistical regulation individual values also described paper alarm limit overall level boundary zones range specified paper basis measuring vibrations electric motor bosch rexroth hydraulic unit
paper discusses mathematics pattern indexing applications recognition visual patterns classification objects represented objects properties matrices shown pattern indexes represented collections inverted patterns solutions pattern classification problems found intersections inverted patterns thus matching original patterns avoided
paper focuses application new learning materials university west bohemia pilsen faculty mechanical engineering department machine design study materials based projects previously applied practice thus help students master become familiar engineering issues practical viewpoint learning materials written structured unified form sequence introduction active two colour models coloured according function machining technology overall drawing documentation authors published elsevier ltd
paper focuses challenge generating theoretical support software development especially human software developers involved software development process outline model coat hanger theorizing development practices model focuses intended rationale actual realization resulting impacts using particular practices varying contexts illustrate use model studied recent practice oriented articles journal science computer programming survey articles journal showed articles four studied software development professional organizations actual software practitioners informants coat hanger model used identify theoretical strengths weaknesses four practice descriptions analysis used basis declare potential model conceptual aid structured theorizing software development practices contribution model introduction concretization theorizing done reflection action instead regarding research software practices plainly prevailing viewpoint technical rationality authors published elsevier
paper investigates behavior unidirectional two port equivalent circuit composed electronic gyrator antoniou operational amplifier reciprocal two port built transversal resistance analysis two port equations standpoint correct choice circuit conductance two port operate ideal lossy gyrator due interest practical aspects energy transfer one terminal analysis two port parameters unidirectional circuit diagram performed validity tested circuit results obtained analytically numerical simulation pspice verified experimentally two cases equal different transfer conductance
paper concerned non autonomous modified swift hohenberg equation delta delta vertical bar del vertical bar shown uniform attractor exists external force satisfies translation bounded condition instead translation compactness order overcome difficulty caused critical nonlinearity terms parameter belonging real set take advantage gagliardo nirenberg inequality several times
paper devoted study aubin lipschitz like property isolated calmness particular non monotone generalized equation arising electronics variational non smooth analysis applied theory non regular electrical circuits involving electronic devices like ideal diodes practical diodes diacs silicon controlled rectifiers scr transistors also discuss relationship results ones using classical techniques smooth analysis provide simulation several simple electrical circuits chosen order cover common non smooth elements electronics simulations electrical circuits discussed paper performed using xcos component scilab
paper outlines procedure computer controlled calibration combined zero dimensional one dimensional thermodynamic simulation model turbocharged internal combustion engine ice main purpose calibration determine input parameters simulation model way achieve smallest difference results measurements results numerical simulations minimum consumption computing time innovative calibration methodology based novel interaction optimization methods physically based methods selected ice sub systems therein physically based methods used steering division integral ice several sub models determining parameters selected components considering governing equations innovative multistage interaction optimization methods physically based methods allows unlike use well established methods rely optimization techniques successful calibration large number input parameters low time consumption therefore proposed method suitable efficient calibration simulation models advanced ices
paper presents comparison two different rating systems evaluate buildings sustainability leed usa itaca italy thanks application methods two residential buildings located italy leed green building rating system encourages integrated design approach points scheme allots credits building design features deemed improve sustainability includes reductions energy use improvements indoor environment quality protection construction site reduction water consumption use sustainable materials itaca procedure environmental quality rating system adopted italy consists compilation group worksheets one different performance indicator aim describing building environmental quality including maintenance indoor comfort entire life cycle chosen buildings located central italy energy efficient designed according principles bioclimatic architecture even characterized different features five common areas site water energy materials indoor environmental quality identified order compare two methods normalize score original approach transferred also comparison building environmental assessment tools comparison allows prove main features schemes even though two procedures give different importance various areas analysis show proportionality respective normalized final score two examined buildings elsevier ltd rights reserved
paper presents novel simulation tool used numerical analysis nonlinear circuits systems forced strong noise sources perturbed weak periodic signals methodology based linear response theory universal scope applied topologies without restraints dimensionality structure size parameter set main purpose developed algorithm enable efficient numerical analysis nonlinear noise driven circuits systems emphasis stochastic resonance currently computationally expensive monte carlo methods often constitute option available simulation cases linear response models previously developed dimensional canonical scenario shown specialized formulations directly adapted higher dimensional systems compared simple monte carlo integration scheme computational efficiency following proposed algorithm improved several orders magnitude
paper presents proof principle study simultaneous imaging temperature fuel partial density realistic diesel spray using tracer based planar laser induced fluorescence tracer plif fluorescence methylnaphthalene characterized flow cell respect temperature pressure nitrogen atmosphere engine conditions excitation strong spectral red shift increasing temperature used two color lif fuel partial density determined one detection channel technique applied investigation temperature fuel partial density diesel spray studied mpa injection chamber averaged images presented pilot injection revealing maximum temperature difference fuel jet ambience maximum fuel partial density visible start injection mixing temperature increases fuel partial density decreases gas entrainment suitability lif technique single shot measurements demonstrated studying cyclic spray variations allows detailed understanding mixture formation engine combustion enhanced tracer based lif technique first time allows simultaneous quantification temperature fuel partial density elevated temperatures highly relevant diesel engines combustion institute published elsevier inc
paper presents simple transresistor attractive chip analog signal processing proposed circuit offers quite good linearity transfer characteristic first relatively low value output resistance enables voltage mode operation even circuit loaded necessarily high resistor obtained rather low value output resistance circuit due adding transresistor input stage simple rail rail voltage follower author knowledge proposed solution original published yet literature input stage transresistor built mos transistors creates simple quasi linear current voltage convertor output stage built mos transistors plays role precise simple rail rail cmos pair based nonstandard voltage follower respect simplicity headroom follower better conventional based voltage followers preliminary simulation results good agreement theory presented
paper presents visual language help users context aware application represent current situation situations wish detected language formally defined readable understandable humans machines alike inspired regular expressions concept extended concept pattern provides conciseness expressive power allowing specifying negation indicating repeating alternative structures
paper presents analysis effect shape primary silicon crystals sizes stresses deformations surface layer alloy finite elements method fem analysis stereological characteristics studied alloy performed based quantitative metallographic analysis combination statistical analysis used purpose presented simulation tests showed deposition depth maximum stresses strains also allowed determining aforementioned values depending shape silicon crystals studied material intended pistons internal combustion engines therefore analysis surface layer corresponded conditions friction piston cylinder system internal combustion engine power obtained results showed important differences values stresses strains various shape silicon crystals crystals sharp edges caused higher stresses deformation locally rounded shapes
paper presents extended structure minimum variance adaptive control system induction generator aims improve operating behavior electrical short circuit conditions basic design idea limit control physically achievable values thus increasing robustness control system avoiding instability regime control limiting block proposed used purpose moreover short circuit detector enables line setting control penalty factor improving quality controlled output additional customizations control system implemented keep plant operational short time short circuit fault acting abnormal perturbation must also provide good performance normal operating mode
paper presents realization theory discrete time linear switched systems present necessary sufficient conditions input output map admit discrete time linear switched system realization addition present characterization minimality discrete time linear switched systems terms reachability observability prove minimal realizations unique isomorphism also discuss algorithms converting linear switched system minimal one constructing state space representation input output data paper uses theory rational formal power series non commutative variables elsevier ltd rights reserved
paper presents results latvian distribution system operator sadales tikls riga technical university rtu latvian transmission system operator augstsprieguma tikls joint research determine maximum permissible loading level five used cable types development cable loading control methodology includes development maximum achievable cable conductor temperature prediction model conditions broken one network element laboratory five used cable type samples protractedly loaded special test bed simulate critical ambient environment conditions operating cables heating point view currents imitate normal conditions electrical network experimentally gained temperature measurement data used develop mathematical models cable sheath conductor temperature prediction dependence load current loading duration different ambient environment air spray foam soil
paper presents analysis simulation experimental methods eliminate acoustic resonance high frequency high pressure sodium hps lamps integrate intelligent control strategies working device based pulse width modulation pwm output generated microcontroller acoustic resonance high frequency lamp successfully eliminated modulating high frequency driving current via low frequency signal particularly implementing pattern recognition control system enables lamp abilities accurate timing gradient dimming automatic protection intellisense proposed model provide useful information designing intelligent lighting system towards smart cities
paper presents comparison study relational document graph databases social networking web application supporting three types database developed analysis consists data models analysis performance tests data models analysis discusses requirements meeting difficulties different implementation performance tests present results obtained five different tasks analyzed solutions revealed strengths weaknesses analysis showed graph model accurately models reality document database queries occur simplest use terms performance postgresql occurred best
paper presents issue mapping database schema within context possible partial loss semantics moreover authors present methodology mapping relational models association oriented model briefly present association oriented metamodel one authors proposition novel database metamodel proposition productive tool free metamodels defects issues described within paper presented terms case study typical example modeling problems concerned within interest bioinformatics
paper presents optimum design permanent magnet synchronous generator wind power applications proposed optimization strategy deals two contradictory objectives reduce generator costs raise energy yield task accomplished maximizing difference energy proceeds generator costs generator operating cycle taken account weibull function represents wind profile fictitious site thermal model adopted evaluate winding temperature prevent overheating optimally designed machine phase generator direct drive wind turbines results show strategy would produce cost effective machine
paper presents results experimental theoretical investigation pietratagliata cable stayed bridge udine italy ambient vibration tests performed order estimate dynamic characteristics lower vibration modes bridge structural identification carried means manual tuning procedure based finite element models increasingly accuracy analysis allows improve description boundary conditions mechanical interaction bridge components results local dynamic testing used estimate traction cables assess integrity suspending system bridge
paper presents study magnetic signature component equipment engine sincron generator located board ship built non magnetic materials equipment analysed terms physical geometrical similarity criteria algorithm computing electrical circuits global compensation windings correlated ship geometrical shape taken consideration fact winding arrangement symmetrical ship diametrical plan well ship magnetic field paper purpose realise equipment permanent inductive magnetization compensation
paper presents two novel realizations voltage mode first order pass filters circuits use single universal voltage conveyor uvc single capacitor two grounded resistors using two nmos transistors based realizations electronic resistor two symmetrical power supplies presented pass filter circuits easily made electronically tunable proposed filter structures provide inverting non inverting outputs configuration simultaneously high input low output impedances desired easy cascading voltage mode operations non idealities proposed circuits also analyzed compared theoretical results circuits verified spice simulations using tsmc cmos process parameters based evaluation behavior one circuits featuring better performance also experimentally measured using uvc nic integrated circuit
paper presents vector control structures phase motors derived generalized clarke transformation contrast known works authors operate generalized formulas clarke transformation work number actually used phases mostly industrial purposes considered allows perform control calculations stationary orthogonal coordinates beta rotating implementations different control strategies roc rotor oriented control foc field oriented control next paper presents novel concept voltage modulator designed multi phase drive systems operation modulator based extended clarke transformation multiphase systems mathematical model multiphase voltage modulator operating open loop closed loop current control presented selected oscillograms voltage current waveform illustrate properties proposed control structures presented
paper provides subject matter modeling development permanent magnet electric motor control system algorithms control unit operation explored control program math ware permanent magnet electric motor control unit developed unit control breadboard able value operation efficiency electric motor presented electric driver mass dimensional parameters proposed
paper reports fabrication characterization high resolution strain sensors structural materials based silicon insulator flexural resonators manufactured polysilicon low pressure chemical vapour deposition vacuum packaging sensors present sensitivity epsilon strain resolution limit epsilon steel measurement time tensile compressive strain regimes readout sensor implemented transimpedance oscillator circuit implemented printed circuit board microcontroller based reciprocal frequency counter integrated performance sensors steel investigated measurement bandwidths comparison conventional metal strain gauges proposed elsevier rights reserved
past decade witnessed discussions various options overcome groundwater depletion rainwater harvesting rwh artificial recharge methods paper addresses law policy issues relating managed aquifer recharge mar based analysis national water policy india water polices laws indian states concrete case study namely chennai metropolitan area studied detail city chennai state tamil nadu provide favorable atmosphere groundwater recharge making rwh mandatory however legal framework support systematic approaches towards mar administrative praxis ensure groundwater recharge offset increase illegal groundwater extraction
pathogenesis asthma includes complex interplay among airway inflammation hyperresponsiveness remodeling current evidence suggests airway structural cells including bronchial smooth muscle cells myofibroblasts fibroblasts epithelial cells mediate three aspects asthma pathogenesis although studies show connection airway remodeling changes bronchomotor tone relationship two remains unclear transforming growth factor beta tgf beta growth factor elevated airway patients asthma plays role airway remodeling shortening various airway structural cells however role tgf beta mediating airway hyperresponsiveness remains unclear review summarize literature addressing role tgf beta airway remodeling shortening review aim elucidate role tgf beta asthma pathogenesis link airway remodeling airway hyperresponsiveness asthma define tgf beta potential therapeutic target reducing asthma morbidity mortality
performance multiplexer mux multiplexer mux using gaas algaas based optical microring resonator omrr presented mux designed two omrr mux designed three omrr proposed structure mux used design bit logic shifter circuit nonlinear property omrr used optical switch optical logic circuits performance mux mux bit logic shifter circuit analyzed using domain model various important parameters proposed model ratio tau full width half maximum fwhm factor extinction ratio contrast ratio chi amplitude modulation eta also analyzed society photo optical instrumentation engineers spie
performance completely implantable peritoneal artificial pancreas demonstrated principle live diabetic domestic pig device consists smart glucose sensitive gel forms gateway insulin reservoir designed sense glucose deliver insulin peritoneal cavity refilled insulin via subcutaneous ports surgery developed insert diabetes induced streptozotocin stz device filled insulin humulin situ animal observed several weeks time normal access food water several oral glucose challenges blood glucose levels brought mmol non fasted values mmol five days filling device glucose challenge responses improved ultimately starting mmol peak mmol fell mmol min contrasting intravenous attempts reservoir solution removed days blood glucose levels increasingly better controlled rapid return diabetic levels mmol occurred days implying insulin remained device removal reservoir solution thus closed loop system appeared particular influence basal bolus needs days reservoir solution place substantial impact weeks additional insulin manual adjustment given period elsevier rights reserved
performance four sections full scale embankment constructed soft soil examined using fully coupled fully three dimensional finite element analysis four sections similar embankment loadings different improvement options one unimproved one pile support one single layer geotextile reinforced platform pile support one two layers geogrid reinforced platform pile support like field data numerical results show inclusion piles decreases settlement subsoil surface unimproved section addition single layer geotextile reinforcement reduced settlement unimproved section effects geosynthetic reinforcement multiple layers reinforcement performance pile supported embankment discussed relative load transfer calculated using eight existing methods compared field measurements numerical results
performance industrial waste incineration bottom ash controlled low strength material clsm investigated paper quarry dust added clsm mixtures made industrial waste incineration bottom ash quarry dust cement tests fresh density bleeding compressive strength shear strength hydraulic conductivity excavatability carried compressive strength ranges kpa kpa friction angle varies degrees degrees cohesion kpa mixtures found non excavatable indicated quarry dust addition increases compressive strength shear parameters decreases bleeding increases removability modulus
periaqueductal gray pag commonly recognized downstream site neural networks expression variety behaviors thought provide stereotyped responses however growing body evidence suggests pag may exert complex modulation number behavioral responses work unique hub supplying primal emotional tone influence prosencephalic sites mediating complex aversive appetitive responses particular relevance review pag involved influencing complex forms defensive responses circa strike risk assessment responses animals addition discuss putative dorsal pag ascending paths likely convey information related threatening events cortico hippocampal amygdalar circuits involved processing fear learning finally discuss evidence supporting role pag reward seeking note lateral pag part circuitry related goal oriented responses mediating motivation hunt perhaps drug seeking behavior elsevier ltd rights reserved
periodical maintenance railway systems important terms maintaining safe comfortable transportation particular monitoring diagnosis faults pantograph catenary system required provide transmission catenary line electric energy locomotive surface wear caused interaction pantograph catenary nonuniform distribution surface pantograph contact points cause serious accidents paper novel approach proposed image processing based monitoring fault diagnosis terms interaction contact points pantograph catenary moving train purpose proposed method consists two stages first stage pantograph catenary interaction modeled simulation results given failure analysis variety scenarios second stage contact points pantograph catenary detected implemented real time image processing algorithms using actual video images pantograph surface fault analysis divided three regions safe dangerous fault fault analysis system presented using number contact points region experimental results demonstrate effectiveness applicability performance proposed approach
periodical voltage features negative differential conductance ndc region current voltage characteristics high quality gaas alas terahertz resonant tunneling diode detected found oscillations considered taking account phonon excitation stimulated tunneling electrons quantum active region resonance nanostructure undoped quantum well layer sandwiched two undoped barrier layers rearrangements characteristics resonant tunneling diode consequence topological transformation measurement circuit circuit series resistance circuit shunt experimentally studied analyzed revealed substantial changes current voltage characteristics resonant tunneling diode discussed schematically using kirchhoff voltage law
permanent magnet synchronous reluctance machine pmsynrm type permanent magnet synchronous machine pmsm objective provide high reluctance torque realized particularly designed constellation flux barriers rotor machine beside high efficiency supplied power density acoustic evaluation machine performed various applications example hybrid electric vehicles hev study acoustic design pmsynrm presented paper approach improve magnetic circuit varying shape flux barriers introduced using numerical simulations every operating point diagram considered local force density air gap machine calculated analyzed fourier transformation results used analysis criterion
physical properties nanometer scale semiconductors known sensitively influenced aspect ratios intrinsic mechanisms still remain unclear shape controlled anisotropic pbse nanorods obtained means addition mncl aspect ratio nanorods continuously tuned simply modulating amount chloride ions demonstrated optimized concentration anions mmol controls competition thermodynamics kinetics mechanisms emission peaks infrared absorbance photoluminescence spectra significantly tuned aspect ratios respectively strong electric dipole phenomenon localized onside surface pbse nanorods terminated charge found using high spatial resolution axis electron holography furthermore evidenced quantitative analysis mean inner potential surfaces charge charge intensity depended aspect ratio pbse nanorods results provide clear evidence energy gap interval reduces result increasing conduction charge amounts novel strategy facilely shift peak position absorbance photoluminescence emission therefore proposed published elsevier inc
piston assembly complex tribological system within internal combustion engine order fully exploit optimization potential high level system understanding required therefore paper experimental studies two single cylinder engines combined cfd simulation piston ring pack introduced measurement simulation techniques enable holistic approach investigation tribological conditions piston assembly results like comparison crank angle resolved oil film thickness piston assembly friction measurement illustrate implications design parameters piston assembly functional parameters friction oil consumption blow wear acoustics thereby permit purposive system optimization elsevier ltd rights reserved
planning jobsite layouts logistics management major impact performance tunnel construction projects use tunnel boring machines tbms frequently projects reach highest possible production performance due undersized logistics processes insufficient storage capacities paper flexible simulation framework analyzing interactions production logistics processes tunneling jobsites presented formal ontology logistic elements tunneling jobsite developed using sysml formalism based formulation single systems elements combined process chains analyzed influence production processes evaluated formal system description identifies process dependencies resource constraints system elements formulations implemented configurable simulation components construction equipment storage spaces production materials using components jobsite simulation model created jobsite layout represented high level detail geometric shapes used estimating storage capacities movement durations approach uses discrete event system dynamic simulation applies probability functions inputs representing production process times dynamic simulation reveal unknown impacts logistical processes continuous advance processes tbm simulation model tbms integrated determine demand supply processes fast effective comparison different jobsite layouts logistics strategies possible due flexible components analyzing workload construction equipment robust efficient setups developed case study illustrates usefulness simulation framework comparing performance three different jobsite setups tunneling project american society civil engineers
polycrystalline samples lipo prepared solid state reaction technique formation compounds checked ray diffraction technique xrd detailed dielectric electrical properties compounds analyzed function frequency mhz temperature impedance data well fitted two equivalent electrical circuits results modulus study reveal presence two distinct relaxation processes suggesting presence grains grain boundaries sample analysis dielectric constants epsilon loss tangent tan delta frequency shows distribution relaxation times activation energy found arrhenius plot confirms conduction process material due simple hopping mechanism temperature dependence frequency exponent investigated understand conduction mechanism lipo overlapping large polaron tunneling olpt model explain temperature dependence frequency exponent
polynomial fitting method used widely detect cycle slips carrier phases gnss easily computer programming simple algorithm method influenced observation errors sampling rates contribution polynomial fitting method newton interpolation method combined solve influences paper introduce new method theory mathematical model finally test taken prove reliable new method result shows new method well cycle slips detection reduces calculation amount
portrait lady novel dealing passage innocence maturity isabel archer american young woman dispatched europe cosmopolitan aunt presents good number feminine characters display various modes female social existence various degrees adherence norms imposed victorian england victorian age gender roles largely influenced doctrine two spheres according public social sphere implying work outside house social life travel power independence belonged masculine gender women generally restricted private sphere performed roles wives mothers portrait lady displays number immobile women limited confines narrow private domestic sphere assume static role attributed middle upper class women victorian society edith keyes misses molyneux paper focus three female characters accompany isabel archer travels henrietta stackpole mrs touchett mme merle view discuss way challenge adhere patriarchal gender roles imposed victorian society process immersed spaces cultures published future academy www futureacademy org
positive fractional linear systems electrical circuits addressed new classes fractional asymptotically stable unstable electrical circuits introduced caputo riemann liouville definitions fractional derivatives used analysis positive electrical circuits composed resistors capacitors coils voltage current sources positive fractional electrical specially unstable different types electrical circuits analyzed open problems formulated
possibilites using dynamic feedback piezoelectric layers controlling acoustic properties surface investigated investigation shows principle possible achieve desired properties reflection artificial transparency simultaneous transmission reception information using single piezo electric layer layer operates sensor actuator approach described controlling boundary conditions acoustic field study shows work well also practice material electromechanic coupling factor large enough explicit controllers cases given however values electro mechanic coupling factors available materials construction suitable practical purposes due non robustness therefore possibility using multiple layers also investigated turns two layer construction achive properties single layer large elecro mechanic coupling factor specific problem achieving reflection explicit construction realistic controller given requirements robust stability limited voltage amplitudes imply low reflection achieved low high frequencies however large frequency interval possible obtain low reflection shown gain phase margins infinite controller work makes extensive use redheffer star product systematic modelling analysis synthesis system regulator
possible effects chlorpyrifos cpf fish cyprinus carpio exposed sub lethal concentrations cpf weeks evaluated analysis made hematological parameters biochemical parameters histology various organs liver gill muscle three concentrations packed cell volume pcv mean corpuscular hemoglobin red blood cells rbc total protein significantly decreased fish treated cpf whereas parameters white blood cells wbc creatinine glutamic oxaloacetic transaminase got glutamic pyruvic transaminase gpt presented significant increase two higher concentrations however sub chronic exposure cpf resulted histological lesions caused clear damage liver muscles gill tissues fish cyprinus carpio thus may conclude altered biochemical hematological parameters used efficient biomarkers monitoring toxicity cpf aquatic organisms time histopathology proves reliable easy tool toxicological studies
potential harmful effects media violence studied systematically extensively however little attention devoted intrigue struggles people depicted mass media longitudinal randomized experimental group control group pretest posttest design study conducted examine potential effects type series young adults typical popular series select stimulus scrutinizing outline series inspired studies effects media violence one behavioral observation five scales adopted dependent measures study find effect intrigue series six dependent variables finally possible interference variables moderators discussed
potential nanotechnology make possible acquire manipulate large sets data raises fundamental questions privacy human dignity medical privacy allows person withhold medical records information others perhaps fears might affect insurance coverage employment avoid embarrassment caused revealing medical conditions treatments emerging nanoneuroimplants given rise new policy issues developments could used achieve greater safety security individualized healthcare could offer advantages business example tracking monitoring materials products however devices might used ways limit individual group privacy covert surveillance collecting distributing personal information health genetic profiles without adequate consent concentrating information hands resources develop control networks discussions ethical societal aspects nanoneuroimplants tend focus ambient intelligence also called ubiquitous computing changes organization society people communicate interact possible track every citizen store information would predict patterns future behavior important set guidelines use information early development large commercial databases using current technology proceeding rapidly nanoneuroimplants capability accelerate development future therefore privacy key value underpins human dignity thus objective study primarily raise awareness questions concerning privacy human dignity dilemmas created nanoneuroimplants rapidly expanding field breakthroughs research nanoneuroimplants therefore significant impact market enabling new neural prosthetic based technologies ethical awareness analysis must take place order ensure appropriate timely impact various technological applications nevertheless necessary paper proposes clear ethical boundaries legal principles suggests several steps taken responsible regulators international level
potential poly lactic glycolic acid plga microparticles carriers vascular endothelial growth factor vegf demonstrated previous study group found improved angiogenesis heart remodeling rat myocardial infarction model formiga however observed accumulation macrophages around injection site suggested efficacy treatment could reduced due particle phagocytosis aim present study decrease particle phagocytosis consequently improve protein delivery using stealth technology pegylated microparticles prepared double emulsion solvent evaporation method using troms total recirculation one machine system uptake studies monocyte macrophage cells lines raw characterization microparticles developed carried terms particle size encapsulation efficiency protein stability residual poly vinyl alcohol pva vitro release microparticles suitable size intramyocardial injection obtained troms varying composition formulation troms conditions high encapsulation efficiency minimal residual pva content importantly bioactivity protein fully preserved moreover pegylated microparticles released phosphate buffer entrapped protein within reaching plateau within first day vitro study finally use plga microparticles coated peg resulted significantly decreased uptake carriers macrophages compared non pegylated microparticles shown flow cytometry fluorescence microscopy basis results concluded pegylated microparticles loaded vegf could used delivering growth factors myocardium elsevier rights reserved
powertrain system typical proton electrolyte membrane hybrid fuel cell vehicle contains lithium battery package fuel cell stack multi objective optimization powertrain system passenger car taking account fuel economy system durability discussed paper based analysis optimum results obtained dynamic programming soft run strategy proposed real time multi objective control algorithm design soft run strategy optimized taking lithium battery size consideration implemented using two real time algorithms compared optimized dynamic programming results power demand based control method proved suitable powertrain systems equipped larger capacity batteries state charge based control method proved superior cases basis life cycle cost optimized considering lithium battery size equivalent hydrogen consumption battery capacity selection proved flexible powertrain systems equipped larger capacity batteries finally algorithm validated fuel cell city bus gets good balance fuel economy system durability three months demonstration operation elsevier ltd rights reserved
practice continuous integration firmly established mainstream software engineering industry yet many questions surrounding remain unanswered prominent among issue scalability continuous integration reported possible scale difficulties understanding underlying mechanisms causing difficulties shallow however size problematic kind size aspect continuous integration impede based quantitative data six industry cases encompassing close engineers complemented interviews engineers five companies paper investigates correlation continuity continuous integration size found indeed correlation size composition development organization tendency integrate continuously evidence size organization influences ways working turn correlate degree continuity raising question software manufacturability observed developer behavior ostensibly continuously integrating cases necessarily match expectations frequent integration product automatically imply individual developer commits frequently elsevier inc rights reserved
precise fast contactless measurement object surfaces edges sub micrometer resolution plays important role many applications nowadays optical high precision measuring devices used purpose use narrowband point light sources exposing object generates diffraction pattern seen sensor achieve much higher resolution pixel size detector additional information generated diffraction pattern used different algorithms estimating projected edge position sub pixel resolution using additional diffraction pattern information evaluated modelled image sensor pixel size results showed prediction error theoretical projected edge position sensor less could achieved influence measurement noise pixel size adc resolution pixel exposure value discussed presented algorithms
prediction problem network security studied facing massive malicious attacks information alarmed time network security ensured network security situation prediction necessary ensure safety network therefore markov game theory applied predicting network security situation firstly network security situation prediction model constructed based coarse grained treatment secondly prediction model network security situation based markov game theory established basic procedure network security situation prediction established finally simulation network security situation based markov game carried results show markov game theory effective method predicting network security situation
preeminent merit linear nonlinear recursive filters ability represent unknown systems far fewer coefficients nonrecursive counterparts unfortunately nonlinear recursive filters become general unstable large amplitudes input signal paper introduce novel subclass linear parameters nonlinear recursive filters whose members stable according bounded input bounded output criterion shown filters called stable recursive functional link polynomial filters universal approximators causal time invariant infinite memory continuous nonlinear systems according stone weierstrass theorem reduce filter complexity simplified structures also investigated even though simplified filters universal approximators good performance demonstrated exploiting either data measured real systems available literature benchmarks nonlinear system identification
preferential solvation parameters phenobarbital aqueous binary mixtures dioxane butanol propanol ethanol propylene glycol glycerol derived solution thermodynamic properties using ikbi method drug sensitive preferential solvation effects mixtures preferential solvation parameter cosolvent negative almost water rich mixtures positive mixtures similar proportions solvents cosolvent rich mixtures except propanol water mixtures negative values also found mixtures hydrophobic hydration around non polar ethyl phenyl groups drug water rich mixtures could play relevant role drug solvation otherwise mixtures similar solvent compositions cosolvent rich mixtures preferential solvation cosolvent could due acidic behaviour drug
prenatal postnatal early life periods dynamic vulnerable windows brain development important neurodevelopmental phases essential processes structures established exposure adverse events interfere critical sequence events confers high risk subsequent emergence mental illness later life increasingly accepted gastrointestinal microbiota contributes substantially shaping development central nervous system conversely several studies shown early life events also impact gut community due bidirectional communication gut brain possible aberrant situations affecting either organ early life impact studies shown deviations gold standard trajectory gut microbiota establishment development early life lead disorders gastrointestinal tract also complex metabolic immune disorders extended disorders central nervous system understanding gut microbiome shapes brain behavior early life important new frontier neuroscience ibro published elsevier ltd rights reserved
presence viruses thyroid shown whether implicated thyroid diseases spectators investigation important candidate viruses autoimmune thyroid disorders aitd hepatitis virus hcv human parvovirus erythrovirus evb retrospective prospective case control studies conducted pathology slides showed pcr situ hybridization immunohistochemistry evb present thyroid tissues patients autoimmune thyroiditis graves disease thyroid cancer though aitd associated acute evb infection clear whether evb could pathogenetic role autoimmune thyroid diseases pathophysiology many studies shown frequently patients hcv chronic infection chc show elevated serum anti thyroperoxidase tpoab anti thyroglobulin autoantibodies levels ultrasonographic signs chronic subclinical hypothyroidism patients hcv associated mixed cryoglobulinemia hcv aitd prevalent respect controls also hcv patients without cryoglobulinemia papillary thyroid cancer prevalent hcv chc patients controls especially patients recently shown elevated incidence new cases thyroid dysfunction patients results suggest attentive monitoring thyroid function nodules hcv patients risk factors female gender borderline high initial thyrotropin tpoab positivity hypoechoic small thyroid development thyroid disorders
present article describes design process fault finding application mobile devices built support workers performance guiding systematic strategy stay focused fault finding process collaboration project partner manufacturing industry fault diagnosis application conceptualized based human centered design approach iso field study maintenance workers conducted purpose evaluating performance enhancement fault finding three different scenarios well assessing workers acceptance technology workers using mobile device application twice fast fault finding control group without application perceived application useful results indicate vast potential mobile application fault diagnosis contemporary manufacturing systems elsevier ltd rights reserved
present cross sectional study performed using data korea national health nutrition examination survey women older years age demonstrates high sodium intake associated lower bone mineral density sodium intake day risk factor osteoporosis postmenopausal women several studies reported large amount dietary sodium intake highly associated elevated urinary calcium however direct effect excessive dietary sodium intake bone mass risk factor osteoporosis still controversial issue aim present study assess relationship high intake sodium lower bone mass risk osteoporosis adult women cross sectional study performed using data korea national health nutrition examination survey knhanes participants women older years divided premenopausal postmenopausal group groups subdivided five groups according quintiles energy adjusted sodium intake multiple regression analysis performed assess relationships sodium intake lower bone mass multivariate linear regression analysis showed high sodium intake negatively associated bone mineral content bmc bone mineral density bmd postmenopausal women adjusting confounding factors high sodium intake negatively associated bmc bmd lumbar spine postmenopausal women postmenopausal women whose sodium intake day odds ratio risk developing osteoporosis adjustment confounding variables present study suggested high sodium intake could potential risk factor low bone mass adjusting confounding factors postmenopausal women
present investigation aims fill gaps revealed literature regarding limited access advanced novel assessment instruments measuring students ict literacy particular study outlines adaption development validation learning digital networks ict literacy ldn ict test ldn ict test comprises online performance based assessment real time student student collaboration facilitated two different platforms googledocs chat test attempts measure students ability handling digital information communicate collaborate problem solving data derived students grade analyzed using item response theory models unidimensional multidimensional rasch models appropriateness models evaluated examining item fit statistics gather validity evidence test investigated differential item functioning individual items correlations constructs self efficacy collective efficacy perceived usefulness academic aspirations results supported hypothesized structure ldn ict comprising four dimensions significant differences across gender groups identified support existing research found positive relations self efficacy academic aspirations socio economic background sum results provide evidence reliability validity test refinements future use test discussed elsevier ltd rights reserved
present investigation carried examine incidence pattern injuries adolescent multisport athletes youth sports academy injury data prospectively collected athletes seasons total injuries identified time loss injuries overall injury incidence confidence interval incidence time loss injuries incidence growth conditions incidence serious injuries per exposure prevalence overuse injuries growth conditions represented injuries involved lower extremities foot ankle predominant injured body parts knee injuries mostly overuse whereas foot ankle injuries resulted acute mechanism minor moderate injuries accounted muscle tendon osteochondrosis injuries accounted injuries comparing groups squash sport highest injury incidence injuries per athlete higher exposure associated greater overuse relative risk conclusion results study identified high incidence injuries youth sports population striking prevalence overuse injuries suggests need injury prevention protocols adolescent highly trained athletes
present investigation conducted evaluate non invasively various functional skin parameters irritation potential melasma sebum contents following long term application topical cream loaded methanolic extract ananas comosus versus placebo control base healthy adults healthy human volunteers aged years recruited investigation written informed consent taken volunteer single blinded study every volunteer applied formulation one side face placebo side face twice daily period weeks three months different skin parameters skin irritancy melasma sebum contents measured sides face baseline two weeks interval using photometric device mexameter sebumeter draught free room modulated conditions temperature degrees humidity evident results primary skin irritancy observed patch test besides statistical interpretation indicates treatment formulation superior placebo significantly reduced skin irritancy melasma sebum secretions throughout study reaching maximum respectively end study period antioxidant activity extract compared standard antioxidant conclusively active cream loaded fruit extract well tolerated volunteers suitable treat contact dermatitis greasy skin acne seborrheic dermatitis augmenting beauty attraction depigmentation human skin future need clinically evaluate formulations patients compromised skin functions contact dermatitis melasma acne vulgaris order explore actual potential fruit
present paper analyses effect self efficacy sports injury extent effect mediated coping strategies competitive situations shown athletes sportspeople assessed regarding number injuries suffered last months general self efficacy coping strategies regression analysis proved two coping strategies emotional calming risk behavior predicted suffering less injuries respectively path analysis showed self efficacy directly related number injuries indirectly coping strategies unexpectedly greater self efficacy induces coping strategies oriented trying new options risky alternatives risk behavior coping strategies directed control negative emotions emotional calming would supposedly related least risk taking behaviors former increasing later decreasing vulnerability sports injury
present paper considers systematic approach within framework neural mathematics constructing computational procedure procedure aims solve class problems arising control systems distributed parameters systems modeled second order one dimensional hyperbolic partial differential equations hpdes non standard boundary conditions procedure reveals explicit algorithmic parallelism mainly based combination two powerful tools convergent method lines mol cellular neural network cnn paradigm role courant isaacson rees rule riemann invariants correct application mol emphasized procedure illustrated control engineering application overhead crane flexible cable within general context includes modeling based generalized hamilton variational principle synthesis stabilizing controller via control lyapunov functional clf qualitative analysis numerical solving using proposed computational procedure numerical simulations evaluation performances closed loop system procedure ensures convergence approximation preserves basic properties lyapunov stability solution initial problem reduces systematic errors elsevier rights reserved
present paper principally concerned disclosure historical cultural potential waterfront areas modern architectural landscape planning moreover attitude water bodies landscape changed recent years objects nature also integral part spiritual heritage nation historic cultural field actions significant part general complex program ecoresponsible design urban waterfront territories along blocks engineering hydro technological measures functional planning actions landscape spatial composition informative steps digital control author algorithm historical cultural potential disclosure waterfront territories shown paper today territories need efficient ecologically responsible architectural landscape organization due necessary protection environment one side accelerated urbanization process necessary creating comfortable living conditions general trend climate change highly rapid development smart technologies modern world
present paper proposes novel cluster basedmethod named agglomerative concentric hypersphere ach detect structural damage engineering structures continuous structural monitoring systems often require unsupervised approaches automatically infer health condition structure however structure linear nonlinear effects caused environmental operational variability data normalization procedures also required overcome effects proposed approach aims straightforward clustering procedure discover automatically optimal number clusters representing main state conditions structural system three initialization procedures introduced evaluate impact deterministic stochastic initializations performance approach ach compared state art approaches based gaussian mixture models mahalanobis squared distance standard data sets post tensioned bridge located switzerland bridge proposed approach demonstrates efficiency modeling normal condition structure corresponding main clusters furthermore reveals better classification performance alternative ones terms false positive false negative indications damage demonstrating promising applicability real world structural health monitoring scenarios elsevier ltd rights reserved
present paper reports longitudinal associations parenting stress sexual satisfaction among heterosexual couples first year birth first child actor partner interdependence modeling apim used model effects mother father parenting stress months birth sexual satisfaction year birth based social constructivist theory scarcity theory two hypotheses posed mothers parenting stress predict later sexual satisfaction whereas fathers parenting stress predict later sexual satisfaction actor effects mothers parenting stress predict fathers later sexual satisfaction fathers parenting stress predict mothers later sexual satisfaction partner effects average parents somewhat satisfied sex life first hypothesis supported greater parenting stress significantly predicted lower sexual satisfaction mothers fathers second hypothesis also supported mothers greater parenting stress significantly predicted less sexual satisfaction fathers whereas fathers parenting stress significantly predict mothers sexual satisfaction discuss results may interpreted considering social construction gendered family roles
present paper takes original outputonly identification approach named full dynamic compound inverse method fdcim recently published journal authors proposes innovative much enhanced version description general forms structural damping including classically adopted rayleigh damping led extended fdcim formulation offers superior performance targeted identification parameters namely modal properties rayleigh damping coefficients structural features element level input seismic excitation time history synthetic earthquake induced structural response signals adopted input channels fdcim approach towards comparison validation identification algorithm run first benchmark storey shear type frame realistic storey frame also considering noise added response signals consistency identification results demonstrated definite superiority latter fdcim proposal
present pilot study examined effectiveness self help therapy sht hospital nurses japan twenty five hospital nurses female mean age years participated min workshop covering sleep hygiene education brief stress management workshop participants sht group asked practice good sleep habits relaxation techniques keep sleep diary whereas participants control group pre post test questionnaires including japanese version pittsburgh sleep quality index psqi administered week interval assess subjective sleep quality sleepiness depressive symptoms burnout quality life changes outcomes treatment conditions compared using linear mixed models found significant improvement subjective sleep quality global psqi scores sht group cohen participants sleep problems pre test sht group scoring psqi cut point showed significant reduction sleep latency sleep disturbance control group cohen respectively significant improvement found sht group sleepiness although clinically significant change observed subjective sleep quality sleepiness group significant improvement observed either group depressive symptoms burnout quality life results provide preliminary evidence effectiveness sht sleep problems hospital nurses japan
present randomized double blind placebo active drug controlled crossover study assessed residual sedation zaleplon flurazepam active control placebo taken nocturnal awakening patients sleep maintenance insomnia twenty two healthy sleep maintenance insomniacs men mean age received zaleplon flurazepam placebo experimental awakening hours bedtime two consecutive nights three conditions residual sedation measured sleep latency testing postdrug digit symbol substitution symbol copying subjective sleepiness visual analog scale twice morning zaleplon differ placebo measure residual sedation flurazepam showed significant sedation measures residual sedative effects detected hours ingestion zaleplon middle night sleep maintenance insomniacs
present research compared validity popular direct indirect measures self esteem predicting self confident behaviour different social situations line behavioural dual process models implicit explicit self esteem hypothesized related appearing self confident unacquainted others total participants responded rosenberg self esteem scale multidimensional self esteem scale adjective scale measuring explicit self esteem ese participants implicit self esteem ise assessed four indirect measures implicit association test iat name letter task nlt two variants affective priming task reaction time affective priming task apt error based affective priming task apt self confident behaviour observed four different social situations self introduction group ostracism experience iii interview ostracism experience interview one personal life general appearing self confident unknown others independently predicted ese ise indirect measures self esteem expected correlated self esteem apts self esteem iat nlt predicted self confident behaviours important note particular predictive power self esteem apt pertained four criteria incremental ese measures copyright european association personality psychology
present research examines relationship infrahumanization approach two dimensional model humanness issue received little empirical attention study created three unknown groups humanized animalized mechanized granting denying human nature human uniqueness traits attribution primary secondary emotions measured expected participants attributed secondary emotions humanized compared dehumanized groups importantly animalized mechanized groups attributed similar amounts secondary emotions study groups described terms capacity express secondary emotions measured attribution traits results showed infrahumanized group denied traits results highlight importance considering common aspects approaches understanding processes dehumanization
present status development visible light stealth arm equipments analyzed principle visible light stealth realization process introduced kind new method visible light stealth arm equipments based optical fiber technology also presented time application perspectives optical fiber stealth technology arm equipment given theory plays important role modern construction arm equipments far researching meanings military reforms chinese characteristics
present study aimed compare attitudes toward lesbians gay men across three generations turkey participants young people parents grandparents total men women involved short form herek attitudes toward lesbians gay men scale used manovas anovas used analyze data results showed attitudinal differences toward gay lesbian people across generations grandparents negative attitudes whereas parents negative attitudes children comparing attitudes generation across sex found young women liberal attitudes toward gay men compared groups discussion focuses understanding results within unique cultural context turkey
present study aimed examine vulnerability eating disorders among lebanese female young adults well association stress anxiety depression body image dissatisfaction bid dysfunctional eating body mass index religious affiliation christian muslim druze religiosity activity level results showed anxiety greatest effect increasing predisposition followed stress level bid depression restrained eating affiliating christian found significantly decrease vulnerability developing furthermore interaction anxiety intrinsic religiosity found protective role reducing current study emphasized buffering role intrinsic religiosity anxiety vulnerability
present study aimed explore effects psychological pain theory based cognitive therapy pptbct suicide among depressed patients compared control group received usual psychological care upc sample consisted depressed patients healthy control subjects participants completed beck scale suicide ideation bsi beck depression inventory three dimensional psychological pain scale tdpps problem solving inventory psi automatic thoughts questionnaire atq measures differed significantly depressed patients healthy controls clinical participants assigned randomly pptbct control groups week intervention scores related depression suicidal ideation psychological pain automatic thoughts decreased groups post intervention week follow time points compared pre intervention scores bsi scores remained low follow differ significantly post intervention scores pptbct group significantly higher follow post intervention control group pptbct may effectively reduce suicide risk patients major depressive disorder although effects application need confirmed
present study aimed formulate subsequently evaluate sunscreen cream emulsion containing three photo protective filters benzophenone ethylhexyl methoxycinnamate titanium dioxide different percentages formulations stored degrees four weeks investigate stability color centrifugation liquefaction phase separation sun protection factor spf sunscreen cream formulations determined microbiological stability creams also evaluated organoleptic quality carried days interestingly combination benzophenone ethylhexyl methoxycinnamate titanium dioxide preserved physicochemical properties product efficient development different spoilage microorganisms well aerobic plate counts pseudomonas aeruginosa staphylococcus aureus yeast mold counts furthermore good stability observed formulations throughout experimental period newly formulated sunscreen cream proved exhibit number promising properties attributes might open new opportunities development efficient safe cost effective skin care cosmetic pharmaceutical products king saud university production hosting elsevier
present study analyzed capacity mentalization patients bipolar disorder first degree relatives fdr examined implications clinical variables cognitive deficits study recruited patients type fdr paired healthy controls capacity mentalization explored means first secondorder false belief tasks hinting task movie assessment social cognition masc patients fdr found theory mind tom deficit evaluated masc also related worse neurocognitive performance patient fdr evidence tom deficits fdrs supports hypothesis deficits could independent trait marker cognitive deficit research needed fdr patients using sensitive tom assessment instruments masc
present study analyzed retrieval dynamics false recall using externalized free recall task participants studied deese roediger mcdermott lists high low identifiable critical words experiment memory test required participants write words remembered presented list recall output plus related words came mind inclusion output results inclusion output showed highly identifiable critical items frequently generated less identifiable critical items suggesting highly identifiable critical words accessible first phase retrieval time results recall output showed highly identifiable critical items less often falsely recalled low identifiable critical items replication previous findings experiment self reports corroborated participants using editing strategy based identification exclusion critical words identify reject strategy results help fully understand identifiability effect beyond emphasize importance considering intervening dual processes accessibility error correction crucial feature theoretical explanations false memories
present study assessed short training experiment improve spatial abilities using two tools based virtual technologies one focused manipulation specific geometric virtual pieces consisting virtual orienteering game two tools help improve spatial abilities required many engineering problem solving procedures results indicated training activities improved components space ability mental rotation spatial visualization spatial orientation addition concluded differences men women respect spatial ability levels training experiment fact resulted masked training relating daily living leisure activities usually indistinctly performed men women developed industrialized countries
present study examined sympathetic parasympathetic indices autonomic nervous system reactivity moderators prospective association parental management peers via directing youths friendships peer adjustment sample typically developing adolescents participants included adolescents time boys european american african american adolescents time boys adolescents approximately years old respectively address study aims multiinformant multimethod longitudinal design utilized skin conductance level scl respiratory sinus arrhythmia rsa measured baseline period challenge task star tracing reactivity computed difference score task baseline period results path models revealed higher levels mother reported parental directing predicted decreases adolescent reported peer rejection friends deviant behavior relatively low levels physiological arousal response challenge low scl reactivity rsa augmentation exploratory analyses indicated directing associated decreases friends deviant behavior peer rejection particularly among boys exhibited lower levels physiological arousal increases friends deviant behavior among boys exhibited higher levels arousal reflected rsa withdrawal overall findings consistent prior studies revealing benefits parental behavioral control underaroused youth contributing growing literature interplay parenting physiological factors adolescent peer domain
present study examines prevalence correlates exchanging sex drugs money food shelter favors sex exchange among nationally representative sample youth young adults adolescents young adults female male national longitudinal study adolescent health used current sample participants completed home interviews waves results revealed sex exchange reported population wave wave exchanged sex waves males reported exchanging sex females versus respondents reported child sexual abuse likely exchange sex respondents reported form child abuse males females engaged sex exchange greater risk sexually transmitted infections however odds ever exchanging sex highest among males ever gonorrhea although sex exchange studied extensively among homeless runaway youth current study reveals sex exchange also occurs general population
present study examines moderating role unconditional self acceptance self esteem relation frustration intolerance beliefs psychological distress participants one hundred fifty student aged studying three universities comsats institute information technology university management sciences university central punjab lahore pakistan completed demographic information sheet frustration discomfort scale harrington clin psychol psychother rosenberg self esteem scale rosenberg society adolescent self image princeton university press princeton unconditional self acceptance questionnaire chamberlain haaga ration emotive cogn behav ther general health questionnaire goldberg manual general health questionnaire nfernelson great britain results demonstrated moderating effects unconditional self acceptance self esteem relationship frustration intolerance beliefs entitlement achievement emotional intolerance discomfort intolerance psychological distress present findings highlight importance unconditional self acceptance reduces emotional problems students hindering educational personal growth
present study explored time course response inhibition function juvenile delinquents antisocial personality characteristics jdap recording event related potentials nogo task compared healthy participants jdap participants showed similar performance controls trails worse performance nogo trails nnogo pnogo components showed reduction amplitudes jdap participants reflecting early stage associated conflict monitoring late stage inhibition processing respectively data suggest jdap participants exhibited impaired response inhibition function elsevier ireland ltd rights reserved
present study investigated effects diesel exhaust experimental model bleomycin blm induced lung injury fibrosis mice blm intravenously administered nrf nrf cbl mice day mice exposed days days blm injection days blm injection inhalation induced significant inhibition airway clearance function proinflammatory cytokine secretion macrophages increase neutrophils severe lung inflammatory injury greater nrf mice nrf mice contrast inhalation observed induce greater increase hydroxyproline content lung tissues significantly higher pulmonary antioxidant enzyme mrna expression nrf mice nrf mice important risk factor nrf regulates risk inhalation induced immune response blm lung injury fibrosis mice
present study investigated impact diagnostic labels traits age gender defendant various mock juror decisions undergraduate students members community read simulated trial transcript involving case aggravated assault transcript differed terms diagnosis psychopathy antisocial personality disorder apd conduct disorder diagnosis age gender male female defendant effects variables decisions regarding credibility verdict choice risk future violence recidivism treatment amenability investigated results indicated psychopathic defendants rated less credible defendants diagnostic conditions defendants described psychopaths apd also likely found guilty likely receive higher ratings risk future violence recidivism regardless age gender significant main effects interactions concerning age gender variables implications use psychopathy evidence within criminal justice system discussed
present study investigates reciprocal associations positive parenting parental monitoring traits odd children assessed age age data collected sample preschoolers female diagnostic interviews questionnaires answered parents teachers structural equation modeling revealed bidirectional relationship poor monitoring odd poor monitoring age predicting odd age beta odd age predicting poor monitoring age beta poor monitoring age predicted traits age beta traits age predicted positive parenting beta odd beta age results important implications early targeted parenting interventions traits odd
present study investigates whether different directions tensions kinesio tex tape application differently influence precision sensorimotor synchronization defined ability coordinate actions predictable external events healthy participants performed sets repetitive wrist flexion extensions synchronized series paced audio stimuli inter onset interval ioi applied wrist finger extensor muscles facilitatory light moderate tension one inhibitory applications used different sessions standard deviation asynchrony sdasy percentage difference sdasy calculated compared across control cases direction tension application differently influence ability coordinate rhythmic movements auditory stimulus however compared control case sdasy decreased significantly cases ioi independent direction tension effect improving sensorimotor synchronization likely associated variations nature neuro anatomical constraints determining control voluntary movement proposed tested sensorimotor disorders associated intense repetitive exercise check regaining effective motor control
present study reported case myeloproliferative neoplasm mpn patient normal complete blood cell count bone marrow biopsy showed bone marrow hyperplasia elevated megakaryocyte count megakaryocytic dysplasia pleomorphic changes multiple megakaryocyte clusters focal reticulin fiber hyperplasia furthermore genetic analysis revealed patient positive jak mutation negative jak exon mutations bcr abl fusion gene patient condition basically stable time writing patient remained stable condition specific symptoms disease present study also analyzed diagnostic clinical features mpns literature review performed mpn normal complete blood cell count rare disease attention focused entity clinic
present study reports comprehensive nuclear magnetic resonance nmr characterization systematic conformational sampling conformational preferences glycan moieties glycosphingolipids produced large scale quantities bacterial fermentation glycans span across variety families including blood group antigens core structures types fucosylated oligosaccharides core lacto series sialylated oligosaccharides types lewis antigens gpi anchors globosides complementary set glycan determinants occurring glycoproteins glycosaminoglycans also structurally characterized using molecular mechanics based computation experimental computational data generated organized two relational databases queried user user friendly search engine nmr cosy tocsy hmqc hmbc correlation spectra structures available visualization download commonly used structure formats emphasis given use common nomenclature structural encoding carbohydrates glycan molecule described four different types representations order cope different usages chemistry biology web based databases developed non proprietary software open access scientific community available http glycod cermav cnrs
present study seeks ascertain attitudes portuguese psychology students future psychologists toward development children adopted lesbian gay parents participant read vignette describing adoption child lesbian gay persons reading vignette participants rated four different aspects future development adopted child psychosocial adjustment victimization psychological disturbance normative sexuality furthermore participants asked gender interpersonal contact lesbians gay men gender role attitudes attitudes toward lesbians gay men future psychologists attitudes toward developmental outcomes children adopted lesbians gay men associated negative attitudes toward non heterosexuals turn correlated interpersonal contact lesbians gay men adherence gender conservative values results clearly highlight central role social attitudes need cultural competence training future psychologists encourages interpersonal contact non heterosexuals discourages traditional gender roles negative attitudes toward lesbian gay men
present study shows process followed making three dimensional model geometric documentation historical invention renowned spanish engineer agustin betancourt molina forms part rich legacy specifically wind machine draining marshy ground designed present research relies computer aided design cad techniques using autodesk inventor professional software based scant information provided two drawings machine making necessary propose number dimensional geometric hypotheses well series movement restrictions degrees freedom arrive consistent design results offer functional design historic invention
present study sought understand perceived well value future goals possible explanation persons suicidal remain attached goals seen unattainable deliberate self harm patients dsh compared matched hospital controls range measures including current well perceived future well context imagined goal attainment despite dsh group substantially lower current levels well difference groups forecasting future well context imagined attainment dsh participants thought achieving important future goal seen necessary sufficient attaining normal levels future well may function keep attached goals perceived relatively unattainable
present study used data prisoners advance understanding joint effects sex race psychopathology specifically antisocial personality disorder apd psychopathy criminal violence sample comprised male female inmates ages years incarcerated state prisons wisconsin time data collection multivariate analyses used examine sex race psychopathology combinations findings indicate black males females comorbid apd psychopathy likely commit violent crime similarly situated white males gendered patterns aggression may characterize males females aggregate present study clearly highlights importance considering sex race subgroups examining relationship psychopathology violent crime
present study used functional near infrared spectroscopy fnirs measure month old infants hemodynamic response prefrontal cortex pfc visual stimuli differing saliency social value nineteen japanese month old infants watched video clips peek boo social signal performed anime character human hand movements without social signal performed pfc activity infants measured channel fnirs behaviors including looking time recorded simultaneously nirs data showed infants hemodynamic responses pfc generally decreased due stimuli decrease prominent frontopolar covering medial pfc mpfc infants viewing peek boo performed moreover decrease pronounced dorsolateral pfc dlpfc infants viewing peek boo performed human accordingly behavioral data revealed significantly longer looking times peek boo performed human significant difference peek boo non peek boo conditions observed either measure findings indicate infants age may prefer stimuli salient features may effective attracting attentions conjunction previous findings responses self name calling infants similar age hypothesize dynamic function mpfc vicinity part default mode network dmn enhanced self focused stimuli attenuated externally focused stimuli consistently observed adults may already emerged month old infants
present study conducted prenatal rumen buffalo foetii curved crown rump length cvrl ranging days observe histomorphological changes prenatal development lamina epithelialis stratified cuboidal divisible dark basal light superficial zones cvrl days nuclei basal zone centric location eccentric superficial zone ruminal papillae appeared cvrl days whereas keratohyaline granules observed epithelium cvrl days gradual increase height ruminal epithelium increase curved crown rump length surface layer epithelium became flattened showed signs keratinization desquamation cvrl days collagen reticular fibers well differentiated cvrl days tunica muscularis comprised inner circular outer longitudinal smooth muscle cells although reverse orientation muscle fibers also observed conclusion rumen undergoes gradual adaptations prenatal life prior intense changes occur moment birth
present study conducted assess possible risks induced construction gavi dam ilam province western part iran using mike model technique order preference similarity ideal solution purpose vulnerable zone dam site flooding risk gavi river calculated different return periods flooding zones stimulated mike model order check whether dam construction could affect quality gavi river physicochemical quality river water also tested afterwards questionnaire prepared containing inventory possible risks supposed induced construction gavi dam questionnaires placed disposal experts score items based importance questionnaires analyzed using spss software version according total number risk factors identified dam construction risks qualitatively assessed preliminary hazard analysis based results identified risks recognized unacceptable shortlisted risks prioritized final step using technique order preference similarity ideal solution habitat fragmentation weight water pollution weight impacts aquatics weight identified three top priority flooding risks among important corrective measures mitigation risks construction phase pointed restoration land cover conservation areas surrounding dam new wildlife habitat prevention water contamination conservation fish spawning sites
present study undertaken evaluate antidiabetic antioxidant activities cayratia trifolia root extract streptozotocin induced diabetes experimental rats scientifically validate use diabetes parts india ethanolic extract showing highest activity vitro experiments prepared saline administered orally streptozotocin induced albino wistar diabetic rats days biochemical parameters liver muscles glycogen vivo antioxidant activity normal diabetic control standard metformin treated animals determined compared attempt made isolate purify characterize one major secondary metabolites extract range chromatographic spectroscopic techniques treatment streptozotocin induced diabetic rats ethanolic root extract caused significant reduction blood glucose increase body weight serum insulin also maintained lipid profile tests liver kidney functions within normal range compared diabetic control rats almost par standard drug metformin oxidative stress induced decline glutathione catalase liver kidney tissues showed recovery nearly normal level function treatment profile extract showed relatively high concentration beta sitosterol characterized different spectroscopic chromatographic techniques result scientifically comprehensively validate reported use roots indigenous plant diabetes strong antioxidant activity ethanolic root extract suitably compliments antidiabetic effect
present work aims assess efficiency windscreen demisting systems electrical vehicles using infrared thermography image analysis techniques study performed three different vehicles internal combustion engine vehicle icev full electric vehicle uses electric resistance heating vehicle cabin iii full incorporates heat pump demonstrated results performance windscreen demisting systems evs higher icev turn performance efficiency windscreen demisting systems higher elsevier ltd rights reserved
present work focuses formulation optimization algorithm based ant colony search acs technique operational blackfin dsp microcontroller platform intelligent algorithm enables switching appropriate shunt capacitor banks scbs installations bulk consumers electricity improve power factor application mainly targeted cold storages rolling mills traction substation steel plants india scbs installed long period unplanned manner unawareness impact energy savings coupled fiscal incapability users make unable install costly power electronic devices control acs based embedded controller sensitive unpredictable load changes selective capacitors switching cause optimal var control minimum stress system employing distributed computational model based acs becomes ideal tool combinatorial optimization problem select best combination within bank varying sizes varying status signifying dynamically changing search space low cost device reduce penalty billing consumers improving improved metered reading use device lead permeation technology strata needs making energy management possible without human intervention elsevier rights reserved
present work performed frameworks cleansky project aeropzt devoted numerical analysis innovative actuators made piezoelectric materials advanced numerical tool based carrera unified formulation used perform numerical analyses device refined one dimensional structural model used analyses provide accurate results low computational cost thermal loads effects encapsulation used protect piezoelectric element external environment evaluated amplified piezoelectric actuators apas multi layered actuators mlas analysed obtained results used derive guidelines development final design actuator able satisfy project requirements elsevier ltd rights reserved
presented research set croatian context explores beliefs parental maternity leave factors explaining beliefs data gathered nationally representative sample people living croatia participants asked questions beliefs towards parental leave take mother father socio demographic data attendance religious services partners income disparity gender role beliefs results show around men women believe solely mother responsibility use entire leave additional believe father take part leave around believe parents share leave equally men women support equally shared leave take attend religious services less often hold egalitarian beliefs gender division labour dyer partners income disparity results imply gender ideology theory applicable explanation beliefs gender division parental leave compared time allocation theory results multinomial logistic regressions show strongest predictor belief leave take gender role belief less participants believe gender division labour traditionally divided likely support equally shared leave parents implication findings shifts towards supporting gender egalitarian leave take likely occur attitudes toward gender roles become egalitarian general
prevalence osteoporosis sub saharan african ssa countries low however urbanization takes root predicted bone health decrease dramatically bone health semi nomadic ovahimba people namibia investigated context urbanization changes sociocultural environment furthermore data bone health ssa countries scarce exists ethnic specific reference group people black origin included study urban rural living ovahimba people quantitative ultrasound performed sunrise sunset saliva cortisol concentrations measured questionnaire conducted significant difference qus parameters however adjustment confounders sos differed significantly saliva cortisol concentrations differed significantly adjustment confounders saliva cortisol significantly negatively correlated sos giving indication association cortisol concentration qus parameters urban group furthermore showed nutritional transition even though bone health ovahimba good first signs adverse effects urbanization detected beside changes lifestyle may attributed increased cortisol exposure ovahimba people living urban environment due increased psychosocial stress
prevalence pediatric food allergies increased children affecting children united states food allergies short long term emotional physical consequences may result challenges children caregivers currently knowledge low cost easily available evidence based psychosocial resources children food allergies families cellie coping kit food allergies created address need study examined acceptability feasibility cellie coping kit intervention explored learning outcomes associated kit twenty five children ages food allergies caregivers recruited outpatient clinic participating oral food challenge children caregivers introduced cellie coping kit following food challenge four weeks later follow assessments completed evaluate participants impressions intervention results suggest children caregivers found cellie coping kit acceptable feasible participants thought intervention materials trustworthy found kit easy use liked appearance kit would recommend intervention others approximately children caregivers reported learning cellie coping kit cellie coping kit children food allergies generally well received children food allergies families cellie coping kit used help facilitate dialog children caregivers food allergy related issues results promising additional research especially younger children newly diagnosed needed determine intervention achieving targeted goals coping behaviors improved adherence medical recommendations
primary goals compulsory inpatient psychiatric treatment decrease dangerous behaviors help improve functioning safe discharge less restrictive environment obtained study examined aggression rates levels functioning treatment adherence persons treated schizophrenia compared persons treated borderline personality disorder bpd inpatient psychiatric facility half persons engaged least one incident aggressive behavior hospitalization differences types aggression functional deficits two clinical sub groups found addition overall impairment increased likelihood aggressive behavior persons diagnosed schizophrenia whereas irritability social dependence increased risk aggression persons diagnosed bpd treatment interventions target improvement deficits may help reduce intensity severity aggressive behaviors help improve functioning discharge readiness
principle hyperspectral imaging leads variety stripe noise hyperspectral images especially wide stripe noise brings great obstacles interpretation application hyperspectral images aiming wide stripe noise hyperspectral images two level production data considering effect filtering noise ability protecting detail paper proposed fused wide stripe removal method based wavelet transform local interpolation wtli called wtli algorithm one hand uses wavelet transform remove stripe noise much possible hand uses local interpolation protect geometric detailed information achieve purpose removing noise protecting useful information series comparative experiments carried hyperspectral image data good experimental results obtained also shows wtli algorithm better stability universality
probiotic definition requires administration adequate amount order obtain health benefit amount indicated overview given studies investigated dose response relation probiotics human interventions studies divided meta analyses meta analyses specific probiotic strains studies testing two doses probiotic combination study meta analyses effect probiotics antibiotic associated diarrhoea aad suggest dose response effect clostridium difficile associated diarrhoea hand dose response observed end points necrotising enterocolitis prevention atopic dermatitis slow intestinal transit dose respon relation identified meta analyses prophylaxis colorectal cancer relief irritable bowel syndrome dose response relation determined however blood pressure meta analysis observed higher doses greater cfu effective lower doses meta analyses specific strains suggest break point effectiveness lactobacillus rhamnosus treatment acute gastroenteritis children dose response observed two probiotics assessed studies comparing two doses indicate faecal recovery risk reduction aad follow positive dose response relationship end points immune markers general health bowel function exhibit clear dose response relations aad findings compelling meta analyses dedicated dose response studies observe positive correlation dose aad risk findings allow extrapolation suggest studying higher doses end point would worthwhile lack clear dose response end points mean exist present data allow drawing conclusions
problem direction arrival doa estimation non circular signal non uniform linear array investigated generalised esprit gesprit algorithm treated improvement esprit algorithm inter elements spacing array geometry uniform non uniform within half wavelength authors combine gesprit algorithm property propose gesprit algorithm obtain doas signals requires spectrum peak searching moreover computationally efficient search free root gesprit algorithm based polynomial rooting also proposed depress computational cost proposed gesprit algorithms much better estimation performance conventional gesprit algorithm detect sources sensors due property furthermore proposed algorithms work well without estimating phase effectiveness improvement proposed algorithms proved following simulation results
problem india household resources spent education sons daughters access health education reflects gender inequalities regardless caste poor women india suffer malnourishment unemployment exists steady stream research gender disparities poverty india studies focused gender disparities wealthier communities yet economic development whole equal sustainable rapid gender inequalities addressed solution explore gender inequity qualitatively single biography indian woman one authors using power cultural differences researchers american interviewed indian researcher make sense narrative indian woman caught desire pursue education career family community expectation marry start family study offers insights extend knowledge increasing tensions individual choice collective ethic experienced india country transitions free market economy stakeholders focusing biography woman caught family community expectations aspirations education career article highlights impact globalization macro micro level economic sociocultural forces produce unique challenges tensions fast growing market based economy public policy makers play important role assessing impact national human resource development nhrd policies practices emphasize equal opportunities women marginalized communities country india
procedure sharing diagnostic medical reports scanned images patients among doctors secured fashion corresponding suggestions joint treatment creates greatest care patients quicker crucial decisions intrusion detection essential part information network security domain opposition illegal access malicious attacks context new mechanism projected detect offline intrusion detection system medical images proposed scheme deals image blocks matching intrusive normal pattern detection experimental results proposed scheme detects attacks namely dos observation shows proposed model offers high efficient detection accuracy model gives realistic results biomedical images dicom
process agglutination commonly used detection biomarkers like proteins viruses multiple bindings micrometer sized particles either latex beads red blood cells rbcs create aggregates easily detectable give qualitative information presence biomarkers cases detection made simple naked eye observation agglutinates without access kinetics agglutination study address development real time time observation rbcs agglutination using abo blood typing proof concept developed integrated biological protocol suitable use point care poc analysis two dedicated image processing algorithms real time quantitative measurement agglutination anti anti typing reagents dried inside microchannel passive microfluidic chip designed enhance capillary flow blood drop deposit tip biochip established simple biological protocol situ agglutination autologous rbcs achieved means embedded reagents real time agglutination process monitored video recording using training set experiments two real time indicators based correlation variance gray levels optimized confirmed validation set correct discrimination positive negative agglutinations performed within less min measuring real time evolution correlation variance indicators
process detecting plant disease human naked eye difficult expensive practice particularly developing countries like india designing providing fast reliable automated mobile vision based solution tasks great realistic contribution society paper mobile client server architecture leaf disease detection diagnosis using novel combination gabor wavelet transform gwt gray level occurrence matrix glcm opens new dimension pattern recognition proposed mobile disease diagnosis system represents diseased patch multi resolution multi direction feature vector mobile client captures pre processes leaf image segments diseased patches transmits pathology server reducing transmission cost server performs computational tasks gwt glcm feature extraction nearest neighbor classification result sent back users screen via sms short messaging service accuracy rate best condition part paper also focus design human mobile interface hmi useful even illiterate farmers automatically monitor field stage mobile click android currently used run system easily extended mobile operating systems
process urbanization transforms natural landscape impervious land cover affecting ecosystem health receiving water bodies downstream communities changing timing volumes natural flow regime best management practices bmp low impact development lid set mitigating measures considered watershed management mitigate hydrologic consequences urbanization research develops methodology select sites placing lid technologies namely rainwater harvesting permeable pavements reduce hydrologic impacts measured alterations peak flow meeting prespecified budget simulation optimization methodology couples genetic algorithm hydrologic model hydraulic model curve number based models lid technologies trade costs peak flow alteration explored optimizing lid placement varying budget constraints strategies combine detention pond lid explored optimized spectrum design storms including year events trade offs among management strategies designed control storms different sizes analyzed simulation optimization framework methodology applied small watershed texas university campus doi asce american society civil engineers
processing cassava relied mainly equipment used crops developing countries also dearth information regarding engineering properties cassava root products selected engineering properties oko iyawo tme popular cassava cultivar south western nigeria studied study focused physical properties cassava root include mass dimensions peel thickness peel proportion weight ppw also studied frictional properties stainless steel galvanized sheets wooden surfaces moisture content range wet mass necessary information required machine design processing equipment fifty freshly harvested cassava roots selected random used mass length diameters peel thicknesses head middle tail ranged respectively ppw ranged respectively coefficient internal friction cif ranged range moisture content studied coefficient rolling resistance crr obtained using periderm cortex flesh three surfaces respectively coefficient friction cof ranged stainless steel galvanized sheets wood surfaces respectively range moisture contents studied influence moisture content coefficients friction internal friction well periderm cortex flesh three surfaces significant oval root shape established useful information development efficient cassava processing handling harvesting machines
processing technologies woods greenery developing nowadays new scientific direction allowing obtain valuable natural substances use medicine health care cosmetology agriculture industry sodium chlorophyllin one active substances acquired spruce greenery contains derivatives chlorophyll chlorines sodium salts chlorophylline acids etc sodium salts resinous acids pimaric isopimaric abietic labdane types sodium salts fatty acids mainly oleic stearic linoleic due chemical compounds sodium chlorophyllin bacteriostatic regenerative deodorant properties could useful active biomedical component electrospun nonwoven web integrated active chemicals released gradually good solution external use chlorophyll derivatives capitally recover tissues heal wounds burns bedsores also decrease inflammation neutralize toxins ensuring biological safety biodegrable non toxic polymers used composites studies several compositions sodium chlorophyllin subjected investigation range concentrations polyvinyl alcohol solution water used matrix diameters electrospun nanofibers evaluated quantitatively atomic force microscope images laboratory scale microbiological tests performed order evaluate effects human skin dernial fibroblast cells results research showed sodium chlorophyllin effects properties spinning solution electrical conductivity viscosity diameter nanofibers morphology mechanical properties nanomats microbiological test results revealed composites lower concentration sodium chlorophyllin regenerate skin dermal cells composites higher concentration stop regeneration process
product development process hydraulic systems construction machines often supported unidimensional simulations used define properties new parts test system functions simulations also used within concept phase define best suited system layout certain purpose usage simulations concept phase difficult task generally high number different possible concepts different customer usage profiles simulation effort overwhelming without proper process therefore paper shows approach model based concept evaluation respect customer specific usage profiles modular simulation model well downstream customer specific weighting procedure simulation results used paper includes general approach well application hydraulic system excavator
programme discretization famous completely integrable systems associated linear operators launched particular properties second order difference operators triangulated manifolds equilateral triangular lattices studied novikov dynnikov since study included laplace transformations new discretizations complex analysis new discretizations connections triangulated dimensional manifolds general theory discrete connections rank one developed see introduction definitions problem distinguishing subclass sln connections unimodular sln connections satisfy det solved present paper shown connections play important role similar role magnetic fields continuous case theory self adjoint schrodinger difference operators equilateral triangular lattices appendix complete characterization given unimodular sln connections rank thus correcting mistake wrongly claimed reduce canonical connection help communication korepanov complete clarification provided classical theory electrical circuits star triangle transformations connected discrete laplace transformations triangular lattices
programming heterogeneous clusters inherently complex architectures require programmers manage distributed memory computational units different nature fortunately extensive research development frameworks raise level abstraction cluster based applications thus enabling use programming models much convenient traditional one based message passing one proposals hierarchically tiled array hta data type represents globally distributed arrays possible perform wide range data parallel operations paper explore first time development heterogeneous applications clusters using htas order use high level api also heterogenous parts application developed using heterogeneous programming library hpl operates top opencl providing much better programmability experiments show approach attractive alternative obtains large programmability benefits respect traditional implementation based mpi opencl presenting average performance overheads around
progressive integration driver assistance systems das vehicles recent decades contributed improving quality driving experience currently need individualization advanced das aim improving safety security comfort driver particular need adapt vehicle individual preferences requirements driver important research focus work individualized non intrusive monitoring system real time driver support proposed kernel system driver identification module based driving behavior signals high performance machine learning technique scheme suitable development single chip embedded systems moreover measurement units used research nowadays available commercial vehicles deployment system performed minimal additional cost experimental results using reduced set features encouraging identification rates greater obtained working set drivers five driver groups four driver groups three driver groups
proinflammatory cytokine highly expressed epithelial cells pivotal mediator epithelial inflammation particular strongly associated inflammatory skin disease psoriasis cytokines expressed inactive precursor must processed specific proteases become bioactive aim therefore identify protease capable activation explore importance activation psoriasis using keratinocyte based activity assay conjunction small molecule inhibitors sirna gene silencing cathepsin identified major gamma activating protease expressed epithelial cells interestingly cathepsin activity strongly regulated samples extracted psoriasis patients relative healthy controls addition gamma ser identified main product cathepsin dependent cleavage induced psoriasiform changes human skin equivalent models together data provide important mechanistic insights activation highlight cathepsin mediated activation may important development numerous gamma driven pathologies addition psoriasis
proof principle acquisition system ppm repeatability range real time delay less presented system integrated digital control loop high voltage modulator design eth zurich university laval new particle accelerator study cern compact linear collider clic initial specifications presented translated system requirements main design choices discussed pspice simulation results reported prove proposed system meets demanding requirements
propensity delay gratification measured discount rate associated variety positive outcomes including higher rates education savings well lower rates poverty addiction significant literature supports linkage religion self regulation use online experimental approach test influence religious salience intertemporal discount rates experiment used real hypothetical rewards design using large sample able test impact religious primes across variety religious traditions well non religious contrary previous studies find evidence increased religious salience increases observed discount rates furthermore find significant difference impact religious salience across religious groups elsevier inc rights reserved
properties energy conditioning electrical circuits developed powering additional functional blocks autonomous rfid transponders working band analyzed presented paper concept autonomy realized implementing extra functions typical transponder first autonomous system harvest energy electromagnetic field read write devices also possibility gathering information environment available measuring different kind physical quantities electrical device crucial problem consists energy conditioning output voltage current characteristic front end antenna matching harvesting circuit well total instantaneous power load generated internal circuits strongly dependent realized function also energy communication conditions rfid interface properly designed solution improve harvesting efficiency current leakage supply storage matching antenna input circuits order save energy increase operating time battery free system authors present methods increase autonomous operation time even advanced measuring algorithms measuring system wide spectrum sensors dedicated different quantities physical chemical etc also presented results model calculations experimental verifications also discussed basis investigations conducted unique laboratory stand object navigation systems
prospects successful peripheral nerve repair using fibre guides considered enhanced use scaffold material promotes attachment proliferation glial cells axonal regeneration macroporous alginate fibres produced extraction gelatin particle porogens wet spun fibres produced using suspension gelatin particles alginate solution gelatin loading starting suspension resulted gelatin loading dried alginate fibres respectively gelatin content hydrated fibres released distilled water degrees leading rapid formation macroporous structure confocal laser scanning microscopy clsm image processing provided qualitative quantitative analysis mean equivalent macropore diameter pore size distribution estimates maximum porosity pore connectivity clsm also revealed gelatin residues lined macropore cavities infiltrated body alginate scaffolds thus providing cell adhesion molecules potentially advantageous promoting growth glial cells axonal extension macroporous alginate fibres encapsulating nerve cells primary rat dorsal root ganglia drgs produced wet spinning alginate solution containing dispersed gelatin particles drgs marked outgrowth evident distance day cell culture indicating pores channels created within alginate hydrogel providing favourable environment neurite development findings indicate macroporous alginate fibres encapsulating nerve cells may provide basis useful strategy nerve repair elsevier rights reserved
provision contraception adolescents requires specific attention adolescents require contraceptive methods safe effective simple use long acting reversible contraceptive methods preferable choice forced mandated especially situations may compromise safety counselling ability choose method contraception appropriate circumstances method contraception may place chapter devoted evaluating current scientific rationale indication use method contraception adolescents published elsevier ltd
pseudobinary system alo mgo studied temperature range knudsen effusion method combination mass spectrometric analysis vapor phase entire composition range except mol alo boundary vapor phase system consists three species partial pressures obtained used construct section alo mgo phase diagram standard enthalpy formation mgalo spinel determined third law calculations mol derived equations temperature dependences partial pressures vapor species alo mgo system
public profile roman catholic bishops united states results simply interventions political life broad array actions actors within public catholicism broadly conceived article assesses contemporary profile american bishops broad angle particularly light new dynamics papacy francis documenting public catholicism presence ecclesial institutions public institutions lay centered social movements particularly faith based community organizing via case study healthcare reform debate around state children health insurance program affordable care act cultural institutional factors shaping catholic public presence analyzed three dimensions social life institutional leadership authority dynamics within church culture prayer spirituality worship parishes finally conclusion discusses key dynamics likely shape future public catholicism america
purpose digital forensic applications determine flow events unfold alleged incident occurred need identify cause incident flow events preceding incident well prove consistency potential evidence recovered alleged incident demands proactive approach designing digital forensic applications employed investigation incidents field digital forensics applications used unravel cause incidents especially acquisition analysis examination potential digital evidence frequent updating digital devices susceptible involvement digital crime incidents huge challenge digital forensic investigations proactively overcome challenge paper proposes architectural requirement engineering specifications ares process design digital forensic applications proposed ares process outlines design process applications using online neighbourhood watch onw system case study result shows employing ares process designing applications modifiability pluggability maintainability features changes legal requirements achieved thereby accommodating constant upgrade changes associated electronic devices operating systems hardware may sometimes involved investigations
purpose modelling processes compression thermal softening particulate well porous anisotropic materials determine critical stress condition initiates plastic flow material value critical effectiveness thermal softening process depends thermo mechanical parameters material key parameters process proven research strength materials wood sawdust evidently decreases increase temperature influenced also moisture content material determining distribution temperature layer thermally softened material indispensable determine heat transfer coefficient paper presents test fixture measuring heat conduction natural composites materials allowing effect temperature developed author
purpose charpy test determine impact resistance materials makes possible measure impact strength consists breaking standard notched bar using pendulum hammer notch take various forms generally power consumption break bar measured making difference drop height hammer goes broken bar last completely brittle hammer would height fell contrary extremely tough would broken pendulum would fracture energy thus determined called impact strength raised material tough today test identified measuring impact force accordance iso largely used industrial materials however technological evolution industrial materials used manufacturing engineering test methods developed time complexity characterise particularly thin sheet welded pieces tailored blanks used automotive industry however one may see little development domain thin plates regarding thick plates paper reports early history instrumented impact testing started augustin georges albert charpy gives comparative study recent results experiments obtained different welded steel grades means new developed machine called impact tensile crash test simulated crash test presents new ductile brittle transition diagrams concerning different welding techniques concerns dynamic testing welded pieces used automotive industry elsevier rights reserved
purpose paper assess groundwater quality near landfill sites using landfill water pollution index lwpi order investigate scale groundwater contamination three landfills different stages operation taken analysis samples groundwater vicinity studied landfills collected four times year period total groundwater samples analysed pah toc required legal acts landfill monitoring system calculated values lwpi allowed quantification overall water quality near landfill sites obtained results indicated negative impact groundwater quality observed near old landfill improper location piezometer landfill favoured infiltration run road pavement soil water environment deep deposition groundwater level landfill area reduced landfill impact water quality conducted analyses revealed lwpi used evaluation water pollution near landfill assessment variability water pollution time comparison water quality different piezometers landfills time periods applied wqi water quality index also important information tool landfill policy makers public groundwater pollution threat landfill
purpose present study record incidence knee injuries greek artistic gymnasts relation event exercise phase two hundred artistic gymnasts aged years different clubs north south greece volunteered participate study seasons authors twice week registered injury occurred practice event made gymnast miss next practice event session results showed gymnasts sustained knee injuries landing mainly floor routines causing ligament sprains injuries occurring pre competition season usually training time furthermore knee injuries take phase occurred mainly vaulting horse forward rotation exercises first competition level conclusively coaches mainly must use supplementary soft mats training restrict pressure knee joints landing phase control amount jumping effort reduce possibilities increase knee injuries especially particular age group gymnasts
purpose present study test hypothesis depression mediated association stressful life events internet addiction participants randomly recruited vocational schools anhui province china completed succession self completed questionnaires including young internet addiction test adolescent self rating life events checklist zung self rating depression scale structural equation model applied examine mediating role depression association stressful life events internet addiction frequency severity stressful life events higher internet addiction group average internet use group participants internet addiction group experienced depression compared average internet users significant positive correlations stressful life events depression internet addiction detected standardized path coefficients life events depression depression internet addiction significant path life events internet addiction also significant findings suggested life events associated internet addiction directly indirectly depression mediated association life events internet addiction elsevier ltd rights reserved
purpose study explore perceived psychological impact sports injuries sports personal level athlete assessing influence psychological well competitive anxiety participants study athletes gymnasts tennis players ages initially psychological impact injuries produces sports personal life athletes analogical hoc scale beginning season assessed state well ryff scale psychological well beginning competition used sas competitive anxiety scale results show psychological injury impact correlates negatively domain environment dimension psychological well sporting life participants experienced however significant relationships competitive anxiety
purpose article provide overview mental health issues counseling services college campuses usa findings several national surveys reviewed estimate prevalence anxiety depression suicide suicidal ideation violence among college students common prevention treatment programs described particular attention innovative campus wide programs student outcomes research examined determine whether receiving counseling services associated academic performance likelihood graduation article concludes set recommended practices improve effectiveness counseling services campus
purpose article examine potential impact child welfare services risk fatal child maltreatment conducted using subsample children identified prior victims national child abuse neglect data system multivariate level analyses show case management services act protect children death family support services family preservation services foster care results vary type maltreatment experienced author recommends strong conclusions drawn additional research area warranted
purpose exploratory qualitative study explore shifts gender dynamics among somali female refugees immigrated united states used community based approach recruit participants interviewed bilingual interviewer themes developed without preordained concepts results indicated women came searching safety education participants reported increased freedoms power demands within family many women expressed desire maintain cultural religious traditional gender roles implications family therapists include attending intersecting identities somali female refugees
purpose paper analyze different definitions methods delineating spatial boundaries cities impact values city sustainability indicators necessary distinguish inside cities fromt outside calculating values sustainability indicators assess impacts human activities within cities areas beyond boundaries purpose spatial boundaries cities practically detected basis relevant definition city although definition city commonly shared among academic fields three practical methods identifying urban areas available remote sensing science practical methods based population density landcover night time lights methods correlated non negligible differences exist determination urban extents urban population furthermore critical statistically significant differences urban environmental sustainability indicators result three different urban detection methods example average values emissions per capita concentration citieswithmore million residents significantly different among definitions analyzing city sustainability indicators disseminating implication results values based different definitions simultaneously investigated necessary carefully choose relevant definition analyze sustainability indicators policymaking otherwise ineffective inefficient policies developed elsevier rights reserved
purpose paper develop automated acoustic inspection platform earpiece manufacturing pin detector designed automatically locate coil inside earpiece drive pin detector composed eight probes voltage data obtained converter via scanning reading earpiece detector contacts earpiece drive location coil ascertained voltage data automated acoustic inspection platform uses microcontroller picf control integrated system sequence actuators including pneumatic cylinder solenoid step motor drive developed automated machine moves earpieces plate earpiece claw claw moves earpiece position detect coil location locating coil using pin detector acoustic inspection process executed automatically time inspection process seconds
purpose paper explore concept feasibility study economic assessment green building projects benefits preparation financial feasibility study enable client decide considerable confidence whether project feasible worth pursuing completion evaluation decision proceed project significant milestone development methodology used direct observation appropriate study therefore research outcome project proposed green building feasible continue lot meru road klang selangor malaysia authors published elsevier ltd
purpose paper investigate high speed machine design enabled use silicon carbide based power electronic inverters silicon carbide based switching devices superior properties compared silicon based devices able change paradigm high speed machine design high speed machines higher number poles shown reduce machine weight volume compared low pole number machines silicon carbide inverters readily provide high fundamental frequency requirement high pole number machines due mosfet characteristics system level optimization perspective research results presented paper indicate control laws optimize high speed machine given higher priorities designs optimize inverter penalties oversizing loss aspects inverter much less prominent using silicon carbide devices silicon devices
purpose project inform presentation timing coping strategies acutely stressful task integrated visual real time biofeedback display stress management gathered skin temperature electrocardiography electroencephalography data presented coping instruction various time schedules participants played first person shooter computer game heart rate variability hrv preceding following significantly elevated peaks stress times message presented compared times comparable stress message presented general around times significantly elevated heart rate presenting coping instruction resulted increase hrv analogous times elevated message presented downstream results indicated decrease hrv cases results support hrv relatively short time windows peak elevated stress sensitive indicator acute stress confirm presence message physiologically relevant time reduced physiological stress within subset peaks analyzed findings imply presenting coping instructions time acute stress response restores downstream physiological indicators representative stress detrimental
purpose research use protection motivation theory examine base pyramid bop consumers environmentally friendly behaviors bop consumers suffer threat environmental degradation resource scarcity particularly emerging economies benefited worldwide economic development much counterparts middle affluent classes based protection motivation theory investigate threat appraisal coping appraisal affect bop consumers intentions engage pro environmental household behaviors proposed relationships tested using self reported data chinese bop consumers results indicate threat coping appraisal variables related bop consumers low cost high cost household green behaviors theoretical managerial implications discussed elsevier ltd rights reserved
purpose research identify different types fear related starting adhering antiretroviral therapy art among people living hiv plhiv russia data collected russian language internet forum plhiv hivlife info qualitative data analysis focused sections forum users discussed health related issues order identify fears related hiv treatment following types fear revealed fear illness fear learn negative information one health fear side effects fear therapy ineffective fear appropriate medications become unavailable fear lifestyle changes fear well significant others efforts increase uptake adherence art take account fears plhiv
purpose research investigate relationship temperament social cognition including theory mind emotion understanding preschool aged children aged years theory mind measured belief desire reasoning assessment emotion understanding measured affective perspective taking task child temperament provided online parent report consistent previous research theory mind correlated shy socially observant temperament contrast emotion understanding associated attention focusing low intensity pleasure enjoyment low arousal activities theory mind emotion understanding positively related inhibitory control negatively related activity level sum theory mind emotion understanding associated executive functioning correlate distinct social preference temperament dimensions copyright john wiley sons ltd
purpose review provide overview visual snow provide information regarding current treatment options visual snow rare disorder manifesting persistent visual phenomenon seeing numerous tiny snow like dots throughout visual field cause debilitating visual psychological consequences emerging disorder separate associated migraine visual aura neuronal cortical hyperexcitability considered theoretical mechanism persistent positive visual symptoms studies investigated treatment understanding entity begins change expect new treatment approaches treatment trials emerge next decade currently approach consider pharmacologic treatment patients report decreased quality life result resolution disorder difficult accomplish treatment experience even symptom intensity simply reduced many patients find improvement quality life beneficial preferred treatment options include oral lamotrigine slow increase daily maintenance dose daily divided doses tolerated typically achieved advancing dose increments weekly following first weeks therapy oral acetazolamide initial dose daily followed slow increase weeks total daily divided doses higher doses tolerated without increasing risk benefit ratio oral verapamil longacting daily side effects limit dose initiated lower doses short acting verapamil two three times daily substituted higher doses long acting formula tolerated initiating drug treatments low doses slowly increasing weeks tolerability compliance improves allows patients realize full benefits treatment proposed mechanisms microstructural cortical abnormalities hyperexcitability cause may lead new treatment approaches future time medications reported relieve persistent visual phenomena migraine visual aura migraine treatment options worth considering reviewed purpose although clinical trials treatment visual snow lacking due rarity disorder medications reviewed considered use patients experience impact quality life theoretical mechanisms lead cortical hyperexcitability investigated could lead new treatment options meantime medications may provide benefits disabling condition
purpose study compare effects different nations roux gastric bypass rygb intensive medical management imm achieving remission type diabetes mellitus tdm april december randomized controlled clinical trial conducted four teaching hospitals united states taiwan involving participants mild obesity bmi thirty six participants randomly assigned rygb group others imm group partial complete remission tdm defined blood hbac mmol mol mmol mol without antihyperglycemic medication least year duration respectively baseline taiwanese participants lower bmi younger age shorter duration tdm american participants months weight loss greater rygb group populations imm group imm participant either population partial complete remission tdm rygb group substantial proportion subjects achieved complete partial remission taiwanese american participants logistic regression revealed stimulated peptide odds ratio nationality significant predictor diabetes remission adding rygb lifestyle medical management associated greater likelihood remission tdm taiwanese american subjects mild obesity type diabetes residual beta cell function baseline appears major factor predicting remission tdm
purpose study evaluate effect using facebook enriching learning experiences students programming learning another word aim study detect reflections environment programming learning facebook used study carried within scope introduction programming algorithm course taught software engineering department technology faculty university turkey initially facebook group created enrich classroom teaching sixty three freshman engineering students taking course faculty members department joined group study conducted one semester fall semester academic year educational usage facebook scale eufs semi structured interview form used data collection tools study quantitative data descriptively analyzed qualitative data subjected content analysis results obtained study show facebook positive effects providing rich content programming learning increasing extracurricular communication offering cooperative collaborative learning environment increasing motivation bringing different perspectives well negative effects causing distraction decreasing face face communication bringing problems expressing oneself result possible assert facebook efficiently used support classroom teaching strategies enrich learning experiences programming learning wiley periodicals inc comput appl eng educ view article online doi
purpose study explore role health physical education hpe specialist teacher primary school entails new australian curriculum hpe framework requires schools teachers implement hpe key learning area many self perceived physical education teachers voiced concern knowing research investigates teachers best become hpe teachers reminded kirk first time teachers implemented change australia many similarities drawn recent national australian curriculum hpe hpe national statement profile provided foundation construction queensland hpe syllabus recommended kirk study look past lessons present might heading future investigating school responses queensland hpe syllabus curriculum documents within constructionist paradigm interpretivist study conducted methodology chosen construct meanings capturing context school evaluative multiple case study sites three case studies involved one small one medium one large sized brisbane catholic education primary school three case studies selected representative different demographics methods engaged enable precision details semi structured interviews reflective journal observations document analysis data gathered suggest enacting hpe key learning area achievable implementation enhanced hpe leadership underpinned clear communication barriers overcome professional development support study significant nationally findings may wider international interest models school leaders optimise health opportunities within context models teachers become hpe teachers
purpose study assess differences proximal tibial deformity closing wedge opening wedge high tibial osteotomy hto effects difficulty total knee arthroplasty tka conversion surgical simulations hto hto performed computer aided design knee models reconstructed computed tomographic datasets patients median age years range years knees medial osteoarthritis osteonecrosis proximal tibial deformities analysed subsequent tka conversion simulated models interference tibial implant endosteal cortex assessed difference metaphyseal diaphyseal angle hto hto groups degrees degrees mechanical axis hto group shifted laterally relative hto group resection surface tka finally tka tibial implant substantially closer endosteal cortex hto group mean hto group mean difference post operative angular deformities proximal tibia hto hto considered clinically irrelevant risk interference tka tibial implant endosteal bone greater hto hto clinical relevance difference two techniques little influence subsequent tka difficulty regarding proximal tibial deformity although preoperative planning obligatory particularly hto prevent interference tibial implant
purpose study determine time loss tlir non time loss injury rates ntlir youth football decreased implementation injury prevention program study consisted two groups coaches players coaches took program select elements program instituted injury rates players compared pre post reduction irs intervention season reduction may due part coaches completing entire program coaches instituting six elements program continued research needed determine irs youth football consistently reduced implementation program research needed examine impact coaches taking implementing program reduction injuries youth sports
purpose study develop scale urdu language measuring different dimensions afterlife belief scale subjected exploratory confirmatory factor analysis sample individuals men women recruited different cities punjab pakistan exploratory confirmatory factor analysis items retained three well defined factor structures afterlife belief positive negative extinction alpha coefficients subscales ranged convergent discriminant validity subscales afterlife belief scale determined finding relationship pleasant afterlife belief scale unpleasant afterlife belief scale anxiety subscale dass belief equitable world scale results support newly developed scale promising validity
purpose study evaluate correlation histological invasiveness computed tomography value size pure ground glass nodules ggns determine optimal follow resection strategies resected pure ggns retrospectively evaluated maximum diameter value pure ggns measured using computer graphics support system ggns maximum diameter parts per thousand currency sign value parts per thousand currency signa hounsfield units considered noninvasive lesions maximum diameter value considered invasive lesions respect correlation histological type pure ggn maximum diameter parts per thousand currency sign value parts per thousand currency signa specificity sensitivity negative predictive value atypical adenomatous hyperplasia aah specificity sensitivity positive predictive value minimally invasive invasive adenocarcinoma pure ggns maximum diameter parts per thousand currency sign value parts per thousand currency signa nearly always pre invasive lesions therefore surgery carefully selected patients
purpose study evaluate relationships screen time nighttime sleep duration behavioural problems sample preschool children china sample children aged years enrolled kindergartens four cities two provinces china evaluate relationships nighttime sleep duration behavioural problems children nighttime sleep duration assessed questionnaires completed parents guardians behavioural problems assessed using strengths difficulties questionnaire sdq clancy autism behaviour scale cabs multivariate analysis used assess associations nighttime sleep duration behavioural problems total sdq cabs scores higher children day sleep duration day adjusting potential confounders children day significantly increased risk total difficulties emotional symptoms conduct problems hyperactivity peer problems prosocial problems well behavioural symptoms autism spectrum disorder similar results found children sleep duration day significantly increased risk emotional symptoms observed short sleep duration preschool children short nighttime sleep duration significantly likely behavioural problems results may contribute better understanding prevention intervention psychosocial problems children
purpose study examine incidence mechanisms acute injuries sport fistball scientific studies injury characteristics yet conducted traditional sport game study conducted prospectively course months total sport specific exposure players reported injuries representing overall injury rate injuries exposure injuries classified bagatelle injuries majority injuries located knee followed elbow hip ankle injuries resulted longest impairment sports participation common types injury abrasions contusions distortions muscle strains wrong insufficient equipment commonly mentioned causes injury data indicate injury risk fistball rather high however sport considered high risk sport injuries slight prevent players training competition injury prevention strategies include development fistball specific protective equipment focus knee elbow joint
purpose study explore parents navigate sex related concepts young children study used feminist phenomenological research methods data gathering analysis social development theory positive sexuality framework also used study design participants included parents mothers fathers least one child aged years old researchers performed semi structured individual interviews data analysis included developing themes illustrated essence parent understandings phenomenon two themes emerged data analysis awkward stuff parents never talked findings illustrated relationship parents perceptions social development theory positive sexuality framework feminist analysis revealed gender differences mothers fathers approached sex related discussions children implications practice policy research included
purpose study explore parents perspectives concerns related childhood obesity children health semi structured interviews conducted parents mothers fathers primary school aged children qualitative analysis revealed parents concerned healthy living necessarily obesity per since parents resisted dominant discourse surrounding notion obesity risk important parents though see good parents ensuring healthy nutrition exercise turn led considerable challenges parents including workload increase stress frustration findings discussed terms new ideologies intensive parenting potential influence risk society parenting practices
purpose study explore content personal constructs people diagnosed bulimia nervosa expected find differences predominant content construct systems women without analyzed constructs elicited using repertory grid technique women aged years divided two groups clinical group women diagnosed bulimia control group university students constructs categorized using classification system personal constructs cspc composed six themes broken categories study new area called physical included consists three categories results indicated women diagnosed bulimia used significantly constructs related body control group used constructs personal area addition congruent constructs clinical sample predominantly moral related values interests discrepant constructs personal physical findings provide evidence clinical use cspc instrument exploring content personal meaning systems understanding patient personal constructions others useful treatment moreover important clinicians explore content constructs related symptomatic areas could hindering change focus facilitate improvement
purpose study identify factors influence undergraduate college student use emergency contraception level knowledge product order assist development intervention programmes increase use could lead lower rates unintended pregnancies population response rate included surveys students midwestern universities students predominantly female white aged years ranged first year students fourthyear students second year students comprising largest group majority respondents reported heterosexual completing questionnaire reported committed relationship respondents reported sexual intercourse least lifetime sexually active students experienced unintended pregnancy used past months knowledge high knowledge increased use increased integrated behavioural model predicted variance intention construct contributed portion variance except experiential attitude statistically significant path analysis model could used future interventions increase use decrease unintended pregnancies among college students
purpose study investigate possible rapid effects light therapy depressed mood patients seasonal affective disorder participants received hour bright light therapy hour placebo dim red light randomized order crossover design depressed mood measured baseline hour light treatment using two self report depression scales profile mood states depression dejection poms subscale beck depression inventory bdi light effects grouped two sessions significantly greater reduction self report depression scores bdi poms significant modest improvement detected single active light session first study knowledge document immediate improvement light treatment using placebo controlled design clinical sample depressed individuals
purpose study investigate effect ultrasonic scaling teeth restored light cured resin ultrasonic scaling popular periodontal therapy among dentists used removal dental plaque calculus order reduce eliminate inflammation given fact ultrasonic devices used high frequencies perform scaling undesirable consequences loss adhesion increase surface roughness may occur teeth restored light cured resins electrochemical impedance spectroscopy eis scanning electron microscopy used investigate effects ultrasonic treatments dental material hard dental tissue interface ultrasonic scaling eis measurements performed human tooth restored light cured resin filling data analyzed influence ultrasound shown visualization hard dental tissues dental material equivalent electrical circuits study revealed eis measurements ultrasonic scaling affected resistance light cured resin filling dentin whereas enamel affected slightly scanning electron microscopy revealed increase roughness dental material
purpose study investigate effects pulsed yag laser plus glucosamine chondroitin sulfate gcs patients knee osteoarthritis koa examining changes pain knee function well synovial thickness femoral cartilage thickness fct sixty seven male patients participated mean age years weight height bmi group treated high intensity laser therapy hilt gcs exercises hilt gcs group treated gcs plus exercises gcs group received placebo laser plus exercises outcomes measured pain level functional disability using visual analog scale vas western ontario mcmaster universities osteoarthritis index womac respectively fct measured ultrasound examination statistical analyses performed compare differences baseline weeks treatment months follow statistical significance set vas womac significantly decreased groups weeks nonsignificant differences weeks months follow significantly decreased hilt gcs group posttreatment nonsignificant decreases gcs groups well nonsignificant differences fct groups overall pulsed yag laser combined gcs exercises effective gcs exercises alone treatment koa patients
purpose work formulate piperine solid lipid nanoparticle sln dispersion exploit efficacy orally topically piperine sln prepared melt emulsification method formula optimized application factorial design nanoparticulate dispersion evaluated particle size entrapment efficiency zeta potential optimized batch average size entrapment efficiency zeta potential characterized differential scanning calorimetry dsc ray diffraction revealed amorphous nature piperine sln prepared sln administered orally topically cfa induced arthritic rats vivo study using franz diffusion cell indicate piperine sln gel formulation accumulates skin pharmacodynamic study result indicates topical oral piperine evoked significant response compared orally administered chloroquine suspension results elisa show significant reduction tnf treated rat might reason behind dmard action piperine sln
quality caregiver child relationship key well children assumptions based research western countries benefits different types substitute care may questionable applied elsewhere study assessed quality caregiver child relationships association child abuse foster residential care nigeria findings relevant european north american countries looked care entrants england african heritage easy draw wrong conclusions care might received countries study scrutinised children aged years foster residential care settings assessed caregiver child relationship using positive relationship scale child abuse measure covered physical sexual emotional components aggregated single score subsequent analysis explored differences child abuse foster residential care significance factors influencing levels child abuse found children residential care positive relationships caregivers foster care even though abuse occurred settings gender differences experiences child abuse either setting children age significantly likely abused care age children residential care age significant factor associated abuse findings provide perspective children substitute care west african city may useful social workers elsewhere responsible children african heritage suggest abuse often occurs foster homes child carer relationships residential establishments good
question asked interrogate memory potential influence response bias retrieval yet systematically investigated according framing effects field eyewitness testimony retrieval cueing effects cognitive psychology acquiescence bias questionnaire responding question establish confirmatory bias conversely according findings rewarded decision making literature involving mixed incentives question establish disconfirmatory bias across three experiments online laboratory laboratory demonstrate disconfirmatory bias old decreased old responding bias underpinned goal driven mechanism wherein participants seek maximise emphasised response accuracy expense frequency moreover demonstrate disconfirmatory biases generated without explicit reference goal state conclude subtle aspects test environment influence retrieval greater extent previously considered elsevier inc rights reserved
question guiding study following intently realistically rating systems handle building system lifetime expectancies current configuration reliable green points credit allocation green building standards may achieved using six different lifetime shearing layers site structure skin services space stuff reflecting distinct environmental damages six shearing layer concept applied israeli sustainable standard bre environmental assessment method breeam leadership energy environmental design leed green star sustainable building tool sbtool green rating systems found focuses long lifetime expectancy building design breeam leed green star focus shorter lifetime expectancy system design moreover sbtool gives importance building service layers
question subject article intended sociological statistical question practice today mathematicians philosophical question nature mathematics specifically method mathematics since antiquity saying mathematics problem solving expression view method mathematics analytic method saying mathematics theorem proving expression view method mathematics axiomatic method article argued two views mathematical method really opposed order answer question whether mathematics problem solving theorem proving article retraces greek origins question hilbert answer argues godel incompleteness results reasons view mathematics problem solving tenable
question specific functions production emotional tears fulfills received limited attention behavioral scientists report results two studies social impact emotional tears study dutch females perceived helplessness felt connectedness predicted willingness help person depicted crying tearfully perceived friendliness study sample males females three variables mediated effect display tears willingness help results replicate extend previous work add current knowledge showing tearful crying facilitates helping behavior identifying reasons people willing help criers findings help put forth novel predictions impact tearful crying others
radar cross section rcs one main parameters measure stealth performances target rcs calculation efficient method obtain rcs target widely used short period high flexibility stealth technology process rcs calculation firstly geometric model target dispersed mesh model combined simple shapes triangles rcs mesh model calculated therefore whether mesh model could enable reflect target shape directly relates calculation accuracy rcs judged shape parameters mesh elements mesh parameters paper rcs different mesh models different target models calculated influence rules mesh parameters rcs calculation obtained rules provide basic guidance disperse target model mesh model
radar cross section sigma objective measure radar visibility object sigma important concept correct characterization operational performance radar systems furthermore sigma equally essential design development stealth weapon systems platforms recent years seen theoretical development quantum radars radars operate small number photons regime radar target interaction described photon atom scattering processes governed laws quantum electrodynamics theoretically inconsistent use sigma characterize performance quantum radar paper define quantum radar cross section sigma based quantum electrodynamics interferometric considerations discuss theoretical challenges defining sigma well computer simulations sigma sigma simple targets
rainfall data ludhiana period years covering collected school climate change agricultural meteorology study planned find rainfall variability amount rainfall different probability levels year rainfall data analyzed weekly basis work initial conditional probability rainfall different levels using markov chain model addition incomplete gamma distribution also used find occurrence rainfall events different probability levels per cent study results estimation maximum minimum initial probability conditional probability wet dry standard meteorological week results useful deciding sowing time irrigation fertilizer scheduling harvesting time different crops addition study useful determining runoff volume peak runoff rate hence used designing rainwater harvesting structures
rapid growth location based services motivated development continuous range queries networks existing query algorithms usually adopt expansion tree reuse previous query results get better efficiency however high maintenance costs traditional expansion tree lead sharp efficiency decrease paper propose line graph based continuous range lgcr query algorithm moving objects networks characterized novel graph based expansion tree get structure used monitor queries incremental manner particular get developed based line graph model networks simultaneously supports offline pre computation better adapt proposed algorithm different sizes networks improve performance create series related data structures bridgeable edges distance edges correspondingly develop several algorithms including initialization insertion objects filter refinement location update incrementally evaluate continuous range queries finally implement get related algorithms native graph database neoj conduct experiments using real world networks simulated moving objects compare proposed lgcr existing classical algorithm verify effectiveness demonstrate greater efficiency
rate change bone density different peri post menopausal women differences rate change observed bone microarchitecture specifically cortical porosity peri menopausal women increased per year compared per year post menopausal women purpose study compare changes bone density microarchitecture peri post menopausal women years peri post menopausal women selected canadian multicenter osteoporosis study caucasian women scanned dual ray absorptiometry dxa high resolution peripheral quantitative computed tomography pqct baseline follow average years later compare repeat scans automated image registration conducted radius tibia total volumetric bmd bmd total bone area cortical porosity assessed finite element analysis estimated apparent bone strength tibia rate change different groups peri menopausal women per year increase increase slower post menopausal women per year addition post menopausal women increase per year compared slower increase per year peri menopausal women rate change density groups significantly different approximately per year hip dxa per year radius per year tibia pqct year prospective pqct study exploring rate change caucasian peri post menopausal women microarchitectural features represented changed significantly different rate groups group differences detected density measures
rational design molecularly imprinted polymers mips major contributor reputation plastic antibodies high affinity robust synthetic receptors optimally designed produced much reduced cost biological equivalents computational design become routine procedure production mips led major advances functional monomer screening selection cross linker solvent optimisation monomer template ratio selectivity analysis review various computational methods discussed reference published relevant literature since end article described target molecule computational approach applied whether molecular mechanics molecular dynamics semi empirical quantum mechanics initio quantum mechanics hartree fock moller plesset etc dft purpose used detailed analysis given novel techniques including analysis polymer binding sites use novel screening programs simulations mip polymerisation reaction advances molecular modelling computational design synthetic receptors particular serious impact future nanotechnology biotechnology permitting translation mips realms analytics medical technology elsevier rights reserved
received wisdom known effective treatment psychopathic disorders although outcome studies identified effective programmatic treatment psychopathic disorders studies tend leave question open behavioral science established psychopathic disorders respond particular programmatic approach neither psychopathic disorders convincingly proven absolutely resistant treatment treatment known effective psychopathic disorders treatment seems squander resources often missing discussion effective therapeutic measures treat behaviors often occur represent domain pathology psychopathic disorders impulsive aggression brief summary results programmatic treatment psychopathic offenders review focuses pharmacotherapy impulsive aggression psychopathic disorders impulsive aggression occurs psychopathic disorders better controlled treatment substantial benefits would appropriate
recent advancements computation based two phase microfluidics bring light possibility use bubbles microfluidic devices carry chip process control paper four computational models implementing two different logic gates one logic flip flop presented specifically numerical approach used combines navier stokes equation phase field method reported models based generally accepted already experimentally tested chip designs parametric junction model designed connected logic gate models droplet generator wider framework logic gate behavior different operating conditions reveals relevance models microfluidics chip design moreover advantage using simulation platform investigation electrical circuits equivalent microfluidic processes illustrated context focus paper definition cfd models logic gates attempt establish workbench easily accessible study two phase microfluidic processes
recent advent ambient intelligence enabled parallel technological advancements sensing context recognition embedded systems communications paper focuses communication issues embedded systems particularly latency quality service qos metric multi hop communications bluetooth standard examine viability communications embedded systems ami environments applications bluetooth worldwide radio license free technology enables creation low power multi hop networks interconnecting multiple devices bluetooth sets procedure establish piconets point point point multipoint links scatternets multi hop communications hence bluetooth nodes interconnected form wireless networks paper presents research multi hop latency conducted using custom built test platform moreover empirical model derived calculate latency asynchronous links links scatternets always active sniff mode designers ambient intelligent devices networks take advantage model estimation delay bluetooth multi hop networks presented paper
recent developments electron quantum optics quantum hall edge channels given new ways probe behavior electrons quantum conductors brought new quantities called electronic coherences spotlight paper explore relations electron quantum optics signal processing global review various methods accessing single two electron coherences electron quantum optics interpret electron quantum optics interference experiments analog signal processing converting quantum signals experimentally observable quantities current averages correlations point view also gives procedure obtain quantum information quantities electron quantum optics coherences illustrate ideas discussing two mode entanglement electron quantum optics also sketch signal processing ideas may open new perspectives representing electronic coherences quantum conductors understand properties underlying many body electronic state
recent rise nosql movement motivates investigation performance impact new persistence approaches bring model driven engineering consolidated object oriented software architecture report comparative experimental performance results attained combining pattern based domain logic persistence layer based different paradigms describe data model persisted various implementation based mysql neoj mongodb
recent usage control model ucon foundation next generation access control models distinguishing properties decision continuity attribute mutability usage control decision determined combining authorizations obligations conditions presented uconabc core models park sandhu paper attempts identify necessary extensions usage control model express number discretionary access control policies relational data management systems based core aspects propose extension authorization core models concerns negative authorization permits specification explicit denial user access object particular mode
recent years seen increasingly widespread use highly concurrent data structures multi core distributed computing environments thereby escalating priority verifying correctness quasi linearizability quantitative variation standard linearizability correctness condition allow implementation freedom performance optimization however ensuring implementation satisfies quantitative aspect new correctness condition often arduous task paper propose first automated method formally verifying quasi linearizability implementation model concurrent data structure respect sequential specification method based checking relaxed version refinement relation implementation model specification model explicit state model checking method directly handle concurrent systems thread process makes infinitely many method calls furthermore unlike many existing verification methods require user supply annotations linearization points implemented new method pat verification framework experimental evaluation shows method effective verifying new quasi linearizability requirement detecting violations
recently articulated increasingly prominent triarchic model psychopathy tpm posits existence components meanness disinhibition boldness current studies issues addressed first although typically conceptualized isolation trait models personality tpm components may manifestations basic personality dimensions study test whether basic traits five factor model ffm account tpm psychopathy domains ffm domains mean facets mean accounted substantial variance tpm domains suggesting tpm viewed nested within broader trait framework second disagreement personality components necessary sufficient psychopathy study examine issue using subject design expert raters asked view ffm profile tpm domains total score derived study rate degree individual profile would manifest symptoms psychopathy diagnostic statistical manual mental disorders dsm personality disorders variety psychiatric disorders expected profile associated boldness rated less emblematic psychopathy related disorders antisocial personality disorder externalizing disorders profiles meanness total tpm score findings contribute ongoing debate addressing degree domains like articulated tpm necessary sufficient construct psychopathy
recently implemented european higher education configuration based degree master phd structure university basque country upv ehu undergraduate programs consist ects structured years study masters vary ects years study access phd studies requires completion master course cooperative dynamic learning method focused student learning based training development active learning methodologies carried group students along undergraduate master phd programs order make feel confidence research tasks apply grant join phd program develop thesis every effort made promote knowledge research field renewable materials engineering aim research carried evaluation residues industrial processes like proteins polysaccharides design innovative renewable biodegradable materials food packaging applications work arises need reduce problems generated management residues mainly urban ones since materials used food packaging purposes generally discarded one use results showed importance previous knowledge subjects like chemistry materials science offered first second courses bsc chemical engineering moreover abilities acquired students laboratory well results discussion final year project highly valued finally students assimilate great value taking account environmental factors order prepare sustainable materials could high added value market study subject biocomposites msc renewable materials engineering research oriented master considered previous step doctorate studies
relations adolescents habitual usage media violence tendency engage aggressive prosocial behavior school setting examined cross sectional study graders germany completed measures violent media exposure normative acceptance aggression participant ratings prosocial aggressive behavior obtained class teacher media violence exposure unique predictor teacher rated aggression even relevant covariates considered predicted prosocial behavior gender path analyses confirmed direct positive link media violence usage teacher rated aggression girls boys direct negative link prosocial behavior found indirect pathways identified higher aggressive lower prosocial behavior via acceptance aggression normative although significant gender differences media violence exposure aggression prosocial behavior similar path models identified boys girls association professionals services adolescents published elsevier ltd rights reserved
relationship exposure violent electronic games aggressive cognitions behavior examined longitudinal study total german adolescents completed measures violent video game usage endorsement aggressive norms hostile attribution bias physical well indirect relational aggression cross sectionally subsample measured months later cross sectional results showed direct relationship violent game usage aggressive norms indirect link hostile attribution bias aggressive norms combination exposure game violence normative beliefs hostile attribution bias predicted physical indirect relational aggression longitudinal analyses using path analysis showed violence exposure predicted physical indirect relational aggression months later whereas aggression unrelated later video game use exposure violent games influenced physical indirect relational aggression via increase aggressive norms hostile attribution bias findings discussed relation social cognitive explanations long term effects media violence aggression aggr behav wiley liss inc
relationship media violence exposure executive functioning investigated samples adolescents psychiatric diagnosis history aggressive disruptive behavior age gender matched samples adolescents diagnostic statistical manual mental disorders fourth edition dsm american psychiatric association diagnosis adolescents dsm disruptive behavior disorder diagnoses completed measures media violence exposure tests executive functioning moderate strong relationships found higher amounts media violence exposure deficits self report parent report laboratory based measures executive functioning significant diagnosis media violence exposure interaction effect found conners continuous performance test scores media violence exposure executive functioning relationship stronger adolescents disruptive behavior disorder diagnoses results indicate media violence exposure related poorer executive functioning relationship may stronger adolescents history aggressive disruptive behavior wiley periodicals inc
relationship microbe populations active engineered product surfaces relationship surface corrosion human health increasingly recognized materials engineering community critically important study direction microbial contamination biofilms germ colonies leads costs reported extremely high every year infection control epidemics corrosion loss energy infrastructure materials loss throughout world nanostructured surfaces particularly hard surface nanoporous pore radii emerging class surfaces recently recognized important prevention microbial colony growth biofilm formation nanostructured nanoporous surfaces whether made deposited nanoparticles welded nanoparticles formed ion assisted growth surface found display biocidal activity varying efficacy depends microbe nanosurface features rate mortality common pathogens resident ubiquitous bio films attached common engineering surfaces made steels titanium zirconium appears increasing short review look methods manufacture durable highly scratch resistant nanostructuring commonly used engineering surfaces microstructures energy dispersive ray analysis ray photo electron spectroscopy types characterization surfaces presented simple tests required surface engineering community understanding efficacy surface antimicrobial action reviewed surface drying rate dynamics droplet spread proposed literature quick methods correlate well residual antimicrobial activity efficacy even surface abrasion nanostructured surface categorization surface short term antimicrobial action long term action proposed review article test periods span time frames greater years demonstrated high efficacy nanoporous nanostructures preventing bio film formation new comparative results diamond graphite containing surfaces presented brief discussion recently developed plasma application technique creating durable nanoporous surfaces presented although considerable information available regarding tunable surface nanofeatures antimicroabial efficacy need research activity particularly directed toward low cost manufacture rapid characterization durable wear chemical resistant surfaces display permanent antimicrobial behavior
relationship religious fundamentalism humor psychological well examined sample individuals treated drug abuse court mandated outpatient program three separate factors religious fundamentalism found exploratory factor analysis revised religious fundamentalism scale named righteous evil worldview true religion scriptural literalism psychological well individuals court mandated outpatient substance abuse treatment found correlated high levels humor religious fundamentalism psychological well humor found related satisfaction services relationship found religious fundamentalism satisfaction services one factor religious fundamentalism scriptural literalism found associated high levels depression paranoia hostility implications relationships treatment understanding religious fundamentalism psychological well discussed
relationship conscious experience physical symptoms indicators objective physiological dysfunction highly variable depends characteristics person context interaction relationship often breaks entirely case medically unexplained functional somatic symptoms violating basic assumption medicine physical symptoms physiological causes paper describe prevailing theoretical approach problem review evidence pertaining use framework predictive coding propose new comprehensive model body symptom relationship integrates existing concepts within unifying framework addresses many shortcomings current theory describe conditions close correspondence experience symptoms objective physiology might expected likely diverge conclude exploring theoretical clinical implications new account elsevier ltd rights reserved
relative genetic immune protection melanoma nonmelanoma skin cancers vitiligo reassuring results recent studies allow cautiously optimistic discussing risk skin cancer caused therapeutic exposure narrow band ultraviolet light however continue recommend sun protection times avoid burning vitiliginous skin decrease incidental ultraviolet exposure also important perform full skin checks regularly light prolonged courses phototherapy required repigment vitiliginous skin maintain repigmentation thereafter
reliability validity traditional taxonomies limited arbitrary boundaries psychopathology normality often unclear boundaries disorders frequent disorder occurrence heterogeneity within disorders diagnostic instability taxonomies went beyond evidence available structure psychopathology shaped variety considerations may explain aforementioned shortcomings hierarchical taxonomy psychopathology hitop model emerged research effort address problems constructs psychopathological syndromes components subtypes based observed covariation symptoms grouping related symptoms together thus reducing heterogeneity also combines occurring syndromes spectra thereby mapping comorbidity moreover characterizes phenomena dimensionally addresses boundary problems diagnostic instability review development hitop relevant evidence new classification already covers forms psychopathology dimensional measures developed assess many identified components syndromes spectra several domains model ready clinical research applications hitop promises improve research clinical practice addressing aforementioned shortcomings traditional nosologies also provides effective way summarize convey information risk factors etiology pathophysiology phenomenology illness course treatment response greatly improve utility diagnosis mental disorders new classification remains work progress however developing rapidly poised advance mental health research care significantly relevant science matures
reliability based design optimization long span suspension bridge performed considering probabilistic flutter constraint accounting stochastic nature parameters extreme wind velocity experimentally obtained flutter derivatives objective study seek minimum volumes main cables bridge girder varying main cable area girder plate thicknesses satisfying required safety level flutter three methods reliability index approach performance measure approach sequential optimization reliability assessment utilized solve problem main code perform entire rbdo process written matlab linked abaqus finite element models obtain structural responses flas code developed research group compute aeroelastic responses bridge three rbdo methods applied messina bridge project examine numerical performance computational efficiency elsevier ltd rights reserved
religious spiritual aspect alcoholics anonymous philosophy may present greater barrier patients professionals europe united states new research suggests clear advantages prescribed step behaviors practices clinicians europe open voluntary recovery resource
remnants rockslide dams widespread deeply incised river valleys northwest himalayas adjacent pamir mountains central asia january major rockslide estimated volume similar dammed hunza river pakistan rockslide dammed lake lake gojal immediately began form lake overtopped rockslide dam days later spillway excavated surface debris pakistan authorities lake gojal successively reduced volume response spillway widening deepening engineering works may august day impoundment remnant lake still remains using srtm arc second digital terrain data ten high resolution satellite images period march august document river damming environment attabad rockslide track quantify development rockslide dammed lake gojal calculate lake areas volumes various stages filling stable overtopping partial draining final stable configuration introduce method delimiting lake shorelines pixel method produces mean elevation surface srtm dem technique results accurate estimates shoreline elevation corresponding lake areas volumes estimate maximum volume reached lake gojal days overtopping approximately using data also evaluate mitigation works carried pakistan authorities find achieved initial reduction maximum possible volume like gojal would reached without engineering intervention august drawing lake similar achieved reduction maximum volume reached lake gojal overtopping without catastrophic release taking place emplacement rockslide dams behaviour impounded lakes critical hazards communities development infrastructure including hydroelectric facilities region central asia show combination high resolution optical satellite imagery srtm arc second digital topography effective producing key first order data rockslide dammed lakes geomorphic hydrological analysis well evaluation engineering mitigation published elsevier
report deals problem design new generation aircraft technical state monitoring systems using methods artificial intellect key point intellectual support theory system identification applied problem aerodynamic parameter estimation flight data report considers specific aspects parameter identification problem part real time intelligent monitoring system aircraft model object noise identification algorithm estimation identification accuracy formulated presented algorithms tested processing data generated using modern aircraft simulation facility authors published elsevier
research behavior change energy use department energy climate change shows better information monthly electricity bill energy performance certificate epc encourage people reduce energy usage smart meters emerging technology help people know monthly energy consumption gradually replacing mechanical power meters paper investigate special energy monitoring process named non intrusive appliance load monitoring nialm potentially best method give consumers pertinent information respect power consumption however real time feedback feature low cost nialm system still big challenge technology complication nialm algorithms system chip soc technology solve challenge besides including high speed interconnection multi processors integrating field programmable gate array fpga socs may important evolution provides developers powerful tool develop low cost high performance system therefore paper proposed development real time nialm system based soc fpga acceleration elsevier ltd rights reserved
research deals building design aimed meeting strict ecological criteria set european legislation using latest digital technologies parametric designing grasshopper program specifically focused architectural design stage instead providing purely technological solution preferred use technology part architectural concept goal get closer zero energy building concept parametrization technological aesthetic organizational part building single system well parametrization surrounding environment chosen tool research shows one options extend building information model conceptual design stage interconnect data environment
research method identification electronic equipment power characteristics based data bus voltage ripple introduced main purpose achieve recognition equipment power characteristics certain algorithm design provide reference follow intelligent applications bus ripple tester two methods used one frequency spectrum analysis based collected signals due differences spectrum distribution equipment signals collected power time frequency band equipment characteristic distribution different make possible achieve purpose identification time frequency analysis based wavelet transform according difference wavelet energy equipment signals collected power time equipment recognized
research impact tennis ball racket significant improve level tennis reduce sports injuries preliminary study impact tennis ball racket carried paper composed four parts reference existed dynamic model experimental set test system collection analysis experimental data preliminary experimental results compared dynamic model impact dynamic model improved considering every effect impact preliminary results show model used predict tennis impact racket different inbound velocity
research works weibull distribution function proposed weibull dynamic capacity life formula rolling bearings postulated lundberg palmgren revisited reexamined especially material function probabilistic stress life relation structural materials well probabilistic force life relation rolling bearings using three parameter weibull distribution function introduced minimum strength life third parameter new statistical theory treating static dynamic strength materials test rolling bearings developed result stressed volume materials equi stressed field yields stressed volume area length points concerning critical stress failure depending acting loads express number probability products developed rating stress static strength rating stress dynamic strength materials well rating load rolling bearings specified found stress life load life exponent depends strength materials bearings independent weibull slope well stressed volume
researchers study investigated impact mathematics focused parental involvement kindergarten grade children parents well factors prompting impact qualitative analysis consisting parent child teacher interviews year quantitative testing showed significant improvements students mathematics understanding achievement moreover parents teachers improved measures content knowledge hypothesize improved parent content pedagogical knowledge improved parent child interactions around mathematics stimulate children learn school furthermore found aspects parent knowledge dispositions gained analogous teacher mkt termed aspects mathematical knowledge parental involvement aspects include content knowledge valuing students strategies listening students explanations may boost student achievement mathematics
resistance distance two vertices connected graph defined effective resistance corresponding electrical network constructed replacing edge unit resistor degree resistance distance defined sigma subset upsilon degree vertex let set connected graphs order edges paper determine extremal graphs among minimum degree resistance distance
responses sand columns internally reinforced horizontal geotextile layers studied using numerical method sand column modeled using non associated plasticity flow rule numerical results validated laboratory triaxial compression tests carried sand columns diameter reinforced layers geotextile numerical experimental results compared deviatoric stresses volumetric strains numerical analysis also provides insight reinforcement mechanism factors affecting reinforced column response advantage horizontal reinforcement outlined parametric studies influences reinforcement properties reinforcing layer spacing specimen diameter response reinforced sand columns examined numerical results show reinforcement significant influence edge toward center column boundary makes constant inclination angle reinforcement reinforced column low spacing diameter ratio stresses influenced areas developed two consecutive reinforcements overlapping effects compounded lower spacing diameter ratio greater column reinforcement strength improved advantage horizontal reinforcement reinforcement rupture soil reinforcement interfacial slippage cause dramatic collapse entire column elsevier ltd rights reserved
responses waterbodies agricultural programmes measures frequently delayed hydrological time lags unsaturated zone groundwater time lag may therefore impede achievement remediation deadlines described water framework directive wfd omitting time lag catchment characterisation renders evaluation management practices impossible time lag aside regulators national scale manage expectations policy makers larger scales european union demonstrating positive nutrient trajectories catchments failing achieve least good status presently flexible tool developing spatial temporal estimates trends water quality nutrient transport time lags available objectives present study first develop flexible parsimonious framework incorporating existing soil maps meteorological data structured modelling approach secondly demonstrate use grassland arable catchment similar ireland assuming full implementation measures data pertaining solute transport meteorology soil hydraulics depth profile boundary conditions collected catchments low complexity textural data alone gave comparable estimates nutrient trajectories time lags spatial soil series information taking high complexity approach coupling high resolution soil mapping national scale representative profile datasets depth indicated trends nutrient transport months months throughout grassland arable catchments respectively conditions regulators relying data groundwater sampling test efficacy present measures would delayed months months respectively variation meteorological datasets enabled temporal analysis trends nutrient transport time lag estimates tool could help catchment scientists better characterise manage catchments determine locations monitoring mitigation assess efficacy current measures ultimately advise policy makers regulators elsevier rights reserved
results numerical simulation sodium coolant flow fuel assembly partial blocking cross section presented comparison results obtained experimental data confirmed operability mod module intended simulating heat exchange processes cores heat exchange equipment promising nuclear reactors
results design development new generation electromagnetic based energy harvesting systems readily installed various vehicles presented device resembles conventional damper shock absorber commonly used vehicle suspensions devices received increased attention recent years much publicized development genshock group mit students device described study different genshock technology use fluid simpler potentially provide larger amount electrical power presentation provide detailed description development prototype energy harvester including modeling analysis electromagnetic components increased efficiency laboratory test results prototype system indicate watts rms energy realized displacements velocities resemble relative motion across vehicle suspension
retinae many bird species contain depression high photoreceptor density known fovea many species raptors two foveae deep central fovea shallower temporal fovea birds six types photoreceptors rods active dim light double cones thought mediate achromatic discrimination four types single cones mediating color vision maximize visual acuity fovea contain photoreceptors contributing high resolution vision interestingly suggested raptors might lack double cones fovea used transmission electron microscopy immunohistochemistry evaluate claim five raptor species common buzzard buteo buteo honey buzzard pernis apivorus eurasian sparrowhawk accipiter nisus red kite milvus milvus peregrine falcon falco peregrinus found species except eurasian sparrowhawk lack double cones center central fovea size double cone free zone differed species common buzzard double cone free zone temporal fovea three species examined opsin expression central fovea found evidence rod opsin positive cells absent violet sensitive cone green sensitive cone opsin positive cells present conclude double cones also single cones may contribute high resolution vision birds raptors may fact possess high resolution tetrachromatic vision central fovea
rheological properties molding suspensions alumina nanopowder paraffin studied powders specific surface areas surface active substances oleic acid hypermer used hamaker constant alumina particles paraffin wax estimated rough calculation showed gel arise suspensions studied linearly viscoelastic characteristics determined method small amplitude periodic shear frequency range confirmed conclusion flow curves molding feedstock determined broad range shear rates point pseudoplastic character flow rheological studies follows manufacturing engineering ceramics injection molding tire suspensions investigated designing selecting forming equipment realization maximum high shear strains must ensured promote qualitative filling intricately shaped small size molds
ridge furrow rainfall harvesting rfrh system collecting runoff plastic mulched ridges useful method improve crop productivity northwest china performed field study rfrh system combined irrigation reduce water irrigation use increase crop water use efficiency wue semi humid climate amount irrigation using reduced half compared traditional furrow irrigation border irrigation due rainwater harvesting effects results showed treatment effectively alleviated drought stress key periods crop growth jointing stage soil water storage soil layer increased compared respectively soil water consumption maize significantly decreased tasselling stage harvest biomass grain yield wue significantly increased compared respectively compared values significantly increased respectively irrigation amount reduced irrigation wue times higher using irrigation water productivity improved times compared respectively results suggest combining rfrh system irrigation suitable reducing irrigation water use enhancing efficient utilization local rainfall could important applications irrigated fields semi humid semi arid areas elsevier rights reserved
rise cases motor impairing illnesses demands research improvements rehabilitation therapy due current situation service professional therapists meet need motor impaired subjects cloud robotic system proposed provide internet based process upper limb rehabilitation multimodal interaction system therapists subjects connected internet using client server architecture client site gradual virtual games introduced subjects control interact virtual objects interaction devices robot arms computer graphics show geometric results interaction haptic force fed back exercising video audio information kinematical physiological data transferred therapist monitoring analysis way patients diagnosed directed therapists manage therapy sessions remotely rehabilitation process monitored internet expert libraries central server serve supervisor give advice based training data physiological data proposed solution convenient application several features taking advantage extensive technological utilization area physical rehabilitation multimodal interaction
risk speed progression fibrosis compensated decompensated cirrhosis define prognosis liver diseases therefore early detection preventive strategies affect outcomes patients liver disease traditionally diagnosed advanced stage disease part due lack non invasive markers ultrasound elastography measure liver stiffness potentially change paradigm purpose review therefore summarize advances field ultrasound elastography focus diagnosis liver fibrosis cirrhosis clinically significant portal hypertension techniques limitations four types ultrasound elastography exist scarce evidence comparing different techniques majority experience concern transient elastography diagnosing fibrosis cirrhosis patients chronic viral hepatitis said role elastography aetiologies alcoholic non alcoholic liver fibrosis still needs clarification although elastography used diagnose liver fibrosis cirrhosis true potential lies possibility multiple repeated measurements allow treatment surveillance continuous risk stratification monitoring complications elastography may powerful tool personalized medicine elastography exciting technique nature ultrasound imaging limits applicability due risk failures unreliable results key factors limit applicability liver stiffness measurements follows liver vein congestion cholestasis recent meal inflammation obesity observer experience ascites coming years show whether elastography widely adapted general care
risk scalp metastases patients using scalp cooling preservation hair chemotherapy concern poorly described systematic review meta analysis longitudinal studies undertaken evaluate effect scalp cooling versus scalp cooling risk scalp metastasis patients treated breast cancer chemotherapy electronic databases journal specific hand searches articles identified searched patients matched based disease treatment lack metastatic disease sex total full text articles identified review articles ten quantified incidence scalp metastasis scalp cooling time scalp cooling patients evaluated estimated mean time frame months scalp cooling patients evaluated estimated mean time frame months incidence rate scalp metastasis scalp cooling group versus scalp cooling group versus incidence scalp metastases low regardless scalp cooling analysis suggests scalp cooling increase incidence scalp metastases
robust adaptive learning control spacecraft autonomous proximity investigated paper relative motion dynamics firstly proposed transformed state space representation adaptive learning controller allows performing autonomous proximity maneuvers presence uncertain orbital parameters developed unknown disturbances considered modified adaptive learning controller therefore designed presence uncertain parameters unknown disturbances asymptotic stability proposed controllers closed loop systems proven based lyapunov theory different numerical results finally provided compared illustrate performance proposed adaptive learning controllers
role behavioral genetic evidence excusing mitigating criminal behavior unclear research suggested low activity genotype enzyme monoamine oxidase maoa may increase risk aggressive antisocial behavior examining criminal proceedings maoa genotype evidence introduced explored forensic uses behavioral genetic science westlaw lexisnexis legal databases electronically searched cases identify court documents cases involving maoa genotype evidence maoa genotype included records criminal cases italian guilt phase genotype evidence ruled admissible one two cases may contributed conviction lesser charge sentencing phase genotype evidence admissible four five cases one ended lesser sentence five cases used genotype evidence post conviction appeals two resulted sentence reductions even charges sentences reduced difficult gauge effect evidence maoa genotype genotype evidence may lack persuasive effect impact allele particular accused difficult establish elsevier ltd rights reserved
role human cytomegalovirus hcmv postulated trigger systemic sclerosis ssc aim study assess prevalence antibodies hcmv antigens tested past sixty ssc patients multiple sclerosis normal controls ncs anti hcmv positive tested immunoblotting reactivity hcmv antigens expressed arbitrary units aus assessed correlation clinical immunological parameters including types ssc related autoantibodies anti anti hcmv antibodies present ssc patients respectively strong anti reactivity frequent ssc compared ncs anti reactivity inhibited ssc specific autoantigens anti seropositivity correlate demographic clinical immunological features ssc anti hcmv antibodies universally present anti hcmv positive patients ssc rarely seen anti lack disease specificity involved cross reactive responses immunopathogenetic potential questioned
role lymphadenectomy management early endometrial cancer remains controversial recent esmo esgo estro guidelines lymphadenectomy recommended patients endometrioid adenocarcinoma grade deep myometrial invasion complete agreement achieved sweden dna aneuploidy included high risk factor aim study evaluate impact tumor histology figo grade dna ploidy myometrial invasion occurrence lymph node metastasis lnm patients endometrial cancer study design retrospective cohort study based prospectively recorded register data endometrial cancer patients registered swedish quality registry gynecologic cancer figo stages iii verified nodal status included data dna ploidy histology figo grade included multivariable log binomial regression analyses lnm dependent variable cases fulfilled inclusion criteria multivariable analyses revealed increased risk lnm patients tumors risk ratio confidence interval nonendometrioid compared endometrioid histology figo grade compared grade tumors statistically significant association dna ploidy status lnm detected population based nation wide study women endometrial cancer confirms strong association nonendometrioid histology figo grade respectively lnm dna ploidy included preoperative decision making removing nodes new whether lymphadenectomy beneficial women endometrial cancer remains uncertain moreover additional studies needed explore factors reliably predict lymph node metastasis lnm multiple factors including tumor histology grade differentiation dna aneuploidy evaluated associations lnm risk women endometrial cancer verified lymph node status significantly deep myometrial invasion tumors increased lnm risk fourfold whereas dna ploidy essentially impact lnm risk findings confirm predictive relevance myometrial invasion histology grade reported previous single center multicenter studies
rome iii criteria classify patients complaining constipation two main groups patients functional constipation patients constipation predominant irritable bowel syndrome ibs purpose study identify differences intensity symptoms total segmental colonic transit time two types patients performed prospective evaluation outpatients consecutively referred chronic constipation classified according rome iii criteria ibs asked report symptom intensity point likert scale diarrhea constipation bloating abdominal pain stool form reported using bristol scale colonic transit time measured using multiple ingestion single marker single film technique statistical analysis completed discriminant analysis female gender obstructed defecation frequent ibs patients patients ibs patients reported greater symptom intensity patients stool form total segmental colonic transit time different two groups multivariate logistic regression showed two parameters bloating abdominal pain related ibs phenotype discriminant analysis showed two parameters sufficient give correct classification patients study suggests self evaluation abdominal pain bloating helpful colonic transit time classifying patient ibsaeuroc
rorschach based perceptual thinking index pti used identify rate features psychotic disorders effects antipsychotic treatment ratings clear accordingly examined potential effects antipsychotic drugs pti measures patients psychotic bipolar disorder use doses antipsychotic drugs chlorpromazine equivalent cpz day unrelated pti total subscale scores diagnostic group pti scores independently significantly associated psychotic symptomatic severity panss score less female sex findings support validity value pti identifying features psychosis even presence antipsychotic treatment
rostral ventral tegmental area vtar central nucleus amygdala cea considered main regions induction psychological dependence abused drugs morphine main aim study investigate transient inhibition right left side well sides vtar cea lidocaine morphine reward properties using conditioned place preference cpp method male wistar rats days recovery surgery cannulation conditioned morphine cpp apparatus five minutes morphine injection conditioning phase lidocaine administered either uni bilaterally vtar site cea site results revealed lidocaine administration left side right side vtar cea reduced morphine cpp significantly reduction potentiated lidocaine injected sides vtar cea number compartment crossings reduced lidocaine injected sides vtar cea well left side rearing reduced lidocaine injected right left side vtar sniffing rearing increased animals received lidocaine right side reduced group received lidocaine left side cea concluded right left side vtar cea play different roles morphine induced activity reward
salience network plays central role cognitive control integrating sensory input guide attention attend motivationally salient stimuli recruit appropriate functional brain behavior networks modulate behavior mounting evidence suggests disturbances function underlie abnormalities cognitive control may common etiology underlying many psychiatric disorders functional anatomical abnormalities recently apparent studies meta analyses psychiatric illness using functional magnetic resonance imaging fmri voxelbased morphometry vbm particular importance abnormal structure function major cortical nodes dorsal anterior cingulate cortex daco anterior insula observed common neurobiological substrate across broad spectrum psychiatric disorders addition cortical nodes network associated subcortical structures including dorsal striatum mediodorsal thalamus dopaminergic brainstem nuclei comprise discrete regulatory loop circuit cortico striato thalamo cortical loop increasingly appears central mechanisms cognitive control well broad spectrum psychiatric illnesses available treatments functional imbalances within loop appear impair cognitive control specifically may impair self regulation cognition behavior emotion thereby leading symptoms psychiatric illness furthermore treating psychiatric illnesses using invasive non invasive brain stimulation techniques appears modulate cortical subcortical loop integrity effects may central therapeutic mechanisms brain stimulation treatments many psychiatric illnesses review clinical experimental evidence abnormalities cortico striatal thalamic loop circuits major depression substance use disorders sud anxiety disorders schizophrenia eating disorders also review emergent therapeutic evidence novel invasive non invasive brain stimulation treatments may exert therapeutic effects normalizing abnormalities loop thereby restoring capacity cognitive control finally consider series promising directions future investigations role cortico striatal thalamic loop circuits pathophysiology treatment psychiatric disorders
schedules americans live consistent healthy sleep patterns addition poor access educational treatment aids sleep leaves people engaging behavior harmful sleep forgoing treatment sleep disorders created sleep crisis public health issue broad implications cognitive outcomes mental health physical health work performance safety new public policies formulated address issues draw scientific literature recommend following establishing national standards middle high school start times later day stronger regulation work hours schedules eliminating daylight saving time educating public regarding impact electronic media sleep improving access ambulatory home diagnostic testing sleep disorders
search natural principles attracting much interest field skin care fabaceae major agricultural crops potential sources bioactive compounds possible applications human health skin care study concerns biological activities legume crops melilotus officinalis pall lespedeza capitata michx potential use skin care applications effects plant ethanolic extracts doses ranging cell viability assays evaluated using vitro tests hacat human keratinocytes brn fibroblasts adipocyte cell cultures matrix degrading enzymes mtt assay revealed weak effects cell viability significant increase fibroblast growth rate extracts similar induction cell motility two extracts observed keratinocytes fibroblasts officinalis induced stronger effect respect capitata cell free enzymatic assays showed stronger collagenase inhibition capitata elisa assay revealed efficient stimulation fibroblast collagen production officinalis oil red adipocyte staining showed pronounced lipolytic effect officinalis respect capitata extracts showed ability stimulating skin cells order promote tissue regeneration prevent skin aging reduce fat deposition cases different patterns activation inhibition observed data indicate legume crops could profitably exploited skin care applications possibly combined formulations development antiaging anticellulite products elsevier rights reserved
security cryptographic systems major concern cryptosystem designers even though cryptography algorithms improved side channel attacks taking advantage physical vulnerabilities cryptosystems aim gain secret information several approaches proposed analyze side channel information among machine learning known promising method machine learning terms neural networks learns signature power consumption electromagnetic emission instruction recognizes automatically paper novel experimental investigation conducted field programmable gate array fpga implementation elliptic curve cryptography ecc explore efficiency side channel information characterization based learning vector quantization lvq neural network main characteristics lvq multi class classifier ability learn complex non linear input output relationships use sequential training procedures adapt data experimental results show performance multi class classification based lvq powerful promising approach side channel data characterization
seed expand scheme appropriate multiple view stereo since build dense point clouds adaptively avoiding unnecessary computation however due irregularity algorithm suitable parallel computing general public utilities gpu paper first attempt implement irregular seed expand method gpu multiple view stereo problems meanwhile hierarchical parallel computing architecture also proposed maximize usage cpu gpu adaptivity seed expand scheme pushed processing pixel several rounds order maintain regularity gpu implementation every seed exactly behavior single round optimization high adaptivity also improves robustness proposed method thus aggressive matching score view selection method used improve reconstruction completeness extensively without smearing local details lowering accuracy compared state art proposed method achieves higher accuracy completeness standard datasets proposed method also fast maximally five times faster methods running cpu par regular depth map based methods gpu naturally suitable gpu acceleration
selection requirements implemented next software release important complex task software development process considering presence budget constraints conflicting aspects context search based software engineering main objective applying automatic search methods solve complex software engineering problems however methods consider human expertise search especially due difficulty mathematically modeling user preferences consequently user present resistance place little confidence final results given knowledge domain expertise properly considered solution construction paper aims proposing interactive model next release problem using ant colony optimization user define requirements would like include next release employing humans simulator empirical study performed considers real world artificial instances achieved results demonstrate loss score average compared solution human intervention hand algorithm generates solutions met preferences defined users furthermore results showed aco interesting choice interactive search engine given low quantity interactions required reach good solutions elsevier rights reserved
senior consultant senior health adviser genitourinary medicine clinics sent questionnaire hiv testing practice seven clinical scenarios scenario recommended time interval possible exposure final hiv antibody test varied minimum months maximum years results show broad patterns contact someone known hiv positive commonest recommended time interval months known exposure hiv commonest recommendation months clinics replying written policy setting interval elapse possible exposure hiv final test hiv antibodies variation practice within clinics less written policies exist staff clinics recommending inappropriately long intervals final hiv test
several noise level estimation algorithms developed use image processing computer graphics generally exhibit good performance however certain special types noisy images algorithms suitable particularly still challenge use algorithms estimate noise levels complex textured photographic images inhomogeneity original scenes similarly difficult apply conventional noise level estimation algorithms images rendered monte carlo method owing spatial variation noise images paper proposes novel noise level estimation method based histogram modification used accurate estimation noise levels complex textured images rendered images proposed method good performance simple implement efficiently used various image based graphic applications ranging smartphone camera noise removal game background rendition
shape sediment particle reveal part particle transportation history significant variable sediment transport mechanics measuring sediment shapes difficult time consuming task whole sample sediment particle shape quantitative analysis method wsqam applied research sediment statistical analysis shape parameter found using sphericity roundness descriptors three samples collected middle reach yellow river different depths scanning electron microscopy sem used obtain sediment particles images sphericity roundness descriptors represented particle aspect ratio fourier shape coefficient fsc fourier series approximation matched particle outlines statistical results whole sediment particle sample counted wsqam based digital image processing fine sediment particles smooth surfaces accounted approximately observed sediment particles majority sediment particles greater fsc less greater fsc exponentially decayed less two parameters fsc combined describe sediment particle shape combined use two parameters provide reference future sediment related calculations sediment particle shape analysis model programmed fortran rapid flexible proved efficient use wsqam sediment statistical analysis results found accurate international research training centre erosion sedimentation world association sedimentation erosion research published elsevier rights reserved
shape optimization stator rotor important electrical motor design among many motor design parameters stator tooth yoke width determinants noload back emf load torque study proposed equivalent magnetic circuit motor stator efficient stator tooth yoke width shape optimization using proposed equivalent magnetic circuit found optimal tooth yoke width minimal magnetic resistance verify load torque truly maximized optimal tooth yoke width indicated proposed method performed finite element analysis fea calculate load torque different tooth yoke widths study confirmed reliability usability proposed equivalent magnetic circuit
simulation machining system use technology computer graphics experimental teaching production training received attention terms situations accident rate training students initial operation cnc machine tools high great damage machine tools equipment low efficiency teaching training construct cnc experimental platform based simulation technology teaching training paper introduces application principles numerical control simulation system construction elements dynamic graphic simulation technology machining process combination machining examples parts author elaborates operational processes numerical control simulation experimental platform examples show application numerical control simulation technology improve students ability programming operational abilities cnc machine tools maintenance abilities cnc system based control theory system theory information technologies simulation technology used carry dynamic experiments actual envisaged systems computer programming system models simulation last century mainly used aerospace power chemical industry industrial process control engineering fields example using simulation technology shorten design development cycles large aircrafts use flight simulators train pilots ground save lot fuels funds also subject meteorological conditions restrictions sites recent years rapid development science technologies simulation technology penetrated fields teaching researches extensive application teaching electronic circuits experiments mechanical principles experiments automatic control systems simulation principles chemical engineering bringing enormous social benefits time also created considerable economic benefits
simultaneous presentation two noninflammatory pulmonary diseases pulmonary alveolar proteinosis kaposi sarcoma hiv infected patient described year old black race patient admitted hospital general malaise weight loss dyspnea chest pain cough hemoptoic expectoration chest rays revealed patchy bilateral alveolar pattern tendency toward formation condensations serological test revealed hiv positivity counts cells response treatment course thoracic performed showing interlobular thickening intralobular septal lines ground glass opacities crazy paving pattern open lung biopsy performed histopathological diagnosis pulmonary alveolar proteinosis pulmonary made
sinoatrial node san dominant pacemaker heart abnormalities san formation function cause sinus arrhythmia including sick sinus syndrome sudden death better understanding genes signaling pathways regulate san development function essential develop effective treatment sinus arrhythmia including biological pacemakers review briefly summarize key processes san morphogenesis development focus transcriptional network drives san development
smart grid concept takes communications enclosed protected environment substation wider city nationwide area environment cyber security takes key role order secure communications challenge able secure grid without impacting latency time maintaining compatibility older devices non secure services lower level added security must interfere redundancy latency required real time substation automation communications paper studies integrate ieee mac security standard macsec substation environment especially used substation system communications stringent response time requirements zero recovery time defined iec
called three step test limitations exceptions copyright shall allowed certain special cases provided conflict normal exploitation work unreasonably prejudice legitimate interests author grants copyright flexibilities balance interests stakeholders especially within european system circumscribed limitations exceptions essential domain computer law confronted rapid unpredictable global technological developments thus enshrined important international intellectual property treaties proposed third amendment copyright law prc legislature intends adopt test also introducing open ended list limitations exceptions constitutes china specific two step test contravenes prima facie thesis endorsed wto panel case concerning section copyright act contrast court decisions china frequently apply fair use doctrine copyright law neglecting consider peculiar context common law tradition thus unduly expanding chinese courts discretionary power paper summarizes case law china takes comparative approach address divergence judicial application cyber copyright law existing legislation suggests revising proposed article copyright law prc capture due interpretation three step test thereby finessing delineation rights protection free use compensation remuneration principle proportionality argues transplanting fair use doctrine chinese copyright law feasible preconditions endeavouring strengthen judicial reform integrate adjudication systems enhancing coherence efficiency copyright enforcement facilitating consistent dialogues scholars practitioners lawmakers chenguo zhang
called advanced core decompression acd new option tries remove necrotic tissue patients osteonecrosis femoral head avn minimally invasive way use percutaneous expandable reamer refilling resorbable osteoinductive bone graft substitute seventy two hips sixty patients mean follow months acd included study patients underwent physical examination preoperatively six weeks surgery well two follow ups certain phases disease progression size necrotic lesion differentiated basis classification osteonecrosis femoral head steinberg femoral heads collapsed cases analysis survival rates regard defect size revealed largest defects significantly higher rate femoral head collapse smaller defects clinical scores also depending defect size also disease stage current acd technique yet achieved significant improvement success rate core decompression procedures concluded success acd depends especially defect size copyright john wiley sons ltd
social media platform twitter provided hematology oncology community unprecedented novel methods interpersonal communication increased ability dissemination important updates rapidly moving field advent subsequent success disease specific twitter communities enabled interested healthcare stakeholders become quickly organized around unique set rare medical conditions hematologic malignancies historically generally lack large amounts reliable online information one example twitter community mpnsm myeloproliferative neoplasms social media started approximately one half years ago served recognized venue discussion among many members mpn community including patients researchers providers advocacy organizations article focus understanding impact founding community via analysis advanced twitter metrics user experience first year use novel healthcare hashtag
society changing towards new paradigm increasing number old adults live alone parallel incidence conditions affect mobility independence also rising consequence longer life expectancy paper specific problem falls old adults addressed devising technological solution monitoring users video cameras accelerometers gps sensors combined multi modal approach monitor humans inside outside domestic environment machine learning techniques used detect falls classify activities accelerometer data video feeds gps used provide location inside outside domestic environment results monitoring solution imply confinement users closed environment
space time fractional nonlinear schrodinger equation solved mean fractional riccati expansion method solutions include generalized trigonometric hyperbolic functions could useful understanding mechanisms complicated nonlinear physical phenomena fractional differential equations among solutions found first time
specific roles nitric oxide synthases noss bladder smooth muscle remain elucidated examined roles noss beta adrenoceptor mediated bladder relaxation male mice cbl deficient neuronal nos nnos knockout endothelial nos enos neuronal endothelial nos enos neuronal endothelial inducible nos inos controls wild type used immunohistochemical analysis performed bladder responses relaxing agents effects several inhibitors relaxing responses examined bladder strips precontracted carbachol immunofluorescence staining showed expressions nnos enos urothelium smooth muscle bladder isoproterenol induced relaxations significantly reduced nnos mice reduced enos inos mice compared mice relaxation inos mice almost enos mice inhibition activated channel charybdotoxin apamin abolished isoproterenol induced bladder relaxation mice moreover direct activation channel caused comparable extent relaxations among nnos enos mice contrast nonoate donor hydrogen peroxide another possible relaxing factor enos caused minimal relaxations catalase scavenger inhibitory effects isoproterenol induced relaxations results indicate nnos enos substantially involved beta mediated bladder relaxations independent manner activation channels
specimen size significant influence flow behavior zrcualni bulk metallic glass throughout thermoplastic compression processes supercooled liquid region due enhanced structural relaxation recovery enthalpy increases specimen size decreasing based combined differential scanning calorimetry experiments finite element modeling simulations different free volume annihilations caused specific surface area discrepancy considered main cause size dependent free volume variation pre heating process thermodynamics structural relaxation theory introduced provide reasonable explanation size dependent flow behavior elevated temperatures novel prediction model involving size induced free volume variations established considering influences compression deformation variables quantitative theoretical prediction agrees well experimental data indicates developed prediction model accurately describe size dependent free volume annihilation generation thermoplastic forming process furthermore reasonable theoretical analysis size dependent free volume prediction model provide profound understanding size dependent flow behavior relation internal structural evolution behaviors metallic glasses elsevier ltd rights reserved
spiking neural system defined type parallel computing mechanism bio inspired behavior soma several authors employing systems order create efficient arithmetic divisor circuits exploiting maximum intrinsic parallel processing however current neural divisors expend large amount neurons complex spiking rules synchronize input information processed soma work proposes compact neural divisor uses eight neurons two type spiking rules per neuron addition proposed circuit includes dendrite behavior feedback connections dendritic delays reduction dendrite length dendritic pruning conventional systems order simplify synchronization neural processing carried soma results show proposed neural divisor implemented embedded neuromorphic circuits potentially allows use portable applications vision processing systems mobile robots cryptographic systems mobile communication devices elsevier rights reserved
stars project paul scherrer institut psi adopted trace thermal hydraulic code analyses involving interactions system core coupling trace simulate light water reactor lwr core simulator developed configuration codes associated simulation models play central role achieve comprehensive safety analysis capability therefore efforts undertaken consolidate validation strategy implementing rigorous structured assessment approach trace applications principle systematically track evolution given set predicted physical quantities interest qois multidimensional parametric space properly set environment provide code developers code users persistent less affected user effect quantified information sensitivity qois applicability simulation scheme codes methodology input models steady state transient analysis full lwr systems given transient accident critical paths validation process identified could translate defining reference schemes applied downstream predictive simulations illustrate approach validation strategy applied inadvertent blowdown event occurred swiss bwr transient initiated spurious actuation automatic depressurization system validation approach progresses number dimensions different versions trace code methodology dimension case imposed power updated trace core models investigated nodalization dimension changes input model assessed step validation dimension common set qois investigated steady state results include fuel temperature distributions transient part present study evaluated qois include system pressure evolution water carryover steam line seen improvements model predictions resulted small impact system pressure gradient thus confirming persistency downstream mechanical stress estimate whereas water carryover could vary function adopted simulation methodology
state pennsylvania hospital engagement network collaboration hospital system southwestern pennsylvania established goal reducing hospital acquired pressure ulcers month unfavorable trend nurse sensitive clinical indicators called immediate process improvement retrospective chart review resulted identification predominant risk factors placing burn patient high risk pressure ulcer formation implementations pressure ulcer prevention measures inconsistent nurses demonstrated varied levels knowledge products used prevention became imperative examine processes within unit provide nursing education access skin care supplies advanced skin wound care products maintaining skin integrity creation evidence based guidelines necessary improve patient outcomes collaborative team approach influenced nursing physician awareness pressure ulcer risk evidence based prevention guidelines developed consistency early intervention achieved supporting culture safety change interprofessional collaborative practice positive trend pressure ulcer incidence data supports success program
statistical evaluation bearing endurance life tests requires sufficient number repetitions rolling contact fatigue rcf damage assessment based ray diffraction xrd residual stress analysis enables alternative materials engineering approach representative examination one run without losing significant informational value calibrated correlation loading induced decrease minimum initial xrd peak width ratio statistical parameters weibull failure distribution depends condition steel matrix different low tempered martensite microstructures investigated rig tests ball bearings subjected subsurface rcf standard heat treatment condition xrd equivalent value actual life refers failure probability known approximate fatigue induced microstructural changes characterized metallography scanning electron microscopy roughly assigned xrd calibration curve dark etching region occurs flat white bands evolve density parallel ferritic ribbons increases advancing rcf steep white etching bands observed life corresponds failure probability five times large carbonitrided martensite microstructure similar bearing life suggested evaluated rig tests calibration estimated rcf induced microstructural changes decreasing xrd peak width ratio development dark etching regions flat white bands already respectively indicate higher xrd equivalent value approximate nitrogen stabilized steel matrix martensite hydrogen charged service high frequency electric current passage dense surface cracks suffers accelerated rcf leading early failures flat steep white bands observed approximate inside extended dark etching region also increased fatigue crack nucleation faster butterfly like phase transformations occur cold working result visible microstructural changes different metallographic findings investigated martensite conditions reference level approximate discussed framework microscopic model rolling contact fatigue including reheating experiments
stochastic nature combustion instabilities practical land based gas turbines aeroengines com bustors seldom investigated shown wealth information constructive acoustic flame interactions gained scrutinising effects inherent turbulence induced noise forces nonlinear thermoacoustic dynamics particular one presents method based fokker planck formalism identify dynamic pressure signals linear growth rates type flame response nonlinearity potential defining system acoustic energy applied validated experimental data measured lab scale combustion chamber combustion institute published elsevier inc
stratospheric observatory infrared astronomy sofia already successfully conducted flights early science phase sofia pointing requirements especially image jitter requirements less arcsec rms driven design control system since first observation flights image jitter gradually reduced various control mechanisms smooth flight conditions current pointing control system allows achieve standards set early science sofia however increasing demands image size require image jitter less arcsec rms light turbulence reach sofia scientific goals major portion remaining image motion caused deformation excitation telescope structure wide range frequencies due aircraft motion aerodynamic aeroacoustic effects therefore called flexible body compensation system fbc used set fixed gain filters counteract structural bending deformation thorough testing current system various flight conditions revealed variety opportunities improvements currently applied filters solely developed based fem analysis implementing inflight measurements simulation optimization improved fixed gain compensation method identified paper discuss promising results various jitter measurements recorded sampling frequencies using fast imaging tracking camera
striatum plays critical roles action control cognition activity striatal neurons driven glutamatergic input inhibition glutamatergic inputs projection neurons interneurons striatum presynaptic protein coupled receptors gpcrs stands modulate striatal output striatum dependent behaviors despite knowledge substantial number glutamatergic inputs striatal neurons originate thalamus electrophysiological studies assessing gpcr modulation differentiate effects corticostriatal thalamostriatal transmission synaptic inhibition frequently assumed mediated activation gpcrs corticostriatal terminals used optogenetic techniques recently discovered pharmacological tools dissect effects prominent presynaptic gpcr metabotropic glutamate receptor mglu corticostriatal thalamostriatal transmission found agonist mglu mglu induces long term depression ltd synapses onto msns cortex thalamus thalamostriatal ltd selectively blocked mglu selective negative allosteric modulator reversed application antagonist following ltd induction activation mglu also induces ltd thalamostriatal transmission striatal cholinergic interneurons cins pharmacological activation mglu selective activation mglu inhibits cin mediated dopamine release evoked selective stimulation thalamostriatal inputs thus mglu activation exerts effects striatal physiology extend beyond modulation corticostriatal synapses potential influence cognition striatum related disorders via inhibition thalamus derived glutamate dopamine release published elsevier ltd
structural eurocodes given status national standards since conflicting national standards previously used member states european union withdrawn eurocode also adopted design long span suspension bridges however traffic load models eurocode valid bridge spans less traffic load models loaded lengths greater may defined national annexes project specific basis paper discusses traffic loads long span bridges defined aashto lrfd sweden bro great belt east bridge design basis superstructure design honshu shikoku bridge japan highway bridge design code china together codes adopted design long span suspension bridges article proposes traffic load model long span suspension bridges framework eurocode load model multiple lane factors impact factors also taken account recommended traffic load model utilized design suspension bridge main span according design load partial factors resistance partial factor main cable margin safety main cable calculated results indicate recommended traffic load model long span suspension bridges reasonable
studies presented article explored relevance death fears obsessive compulsive disorder ocd study relationships death anxiety variety markers psychopathology examined treatment seeking participants ocd moderate large correlations collett lester fear death scale scores taken initial assessment clinical ratings ocd severity number hospitalizations number medications total number lifetime anxiety related diagnoses identified structured diagnostic interviews obtained study used mortality salience paradigm examine whether experimentally manipulated death cognitions exacerbate compulsive cleaning behaviors among ocd washers treatment seeking participants ocd washers nonwashers randomly allocated either dental pain priming condition following priming participants completed series distraction tasks involving skin conductance recording offered opportunity wash conductive gel hands hypothesized washers went greater efforts cleaning measured washing duration soap paper towel use nonwashers similarly participants condition showed greater cleaning dental pain salience condition however main effects qualified significant interactions washing duration soap use expected simple effect contrasts revealed effect cleaning behaviors significant washers nonwashers clinical implications directions future research discussed
study aimed determine computer vision techniques rooted deep learning use small set radiographs perform clinically relevant image classification high fidelity one thousand eight hundred eighty five chest radiographs patients obtained january july institution retrieved anonymized source images manually annotated frontal lateral randomly divided training validation test sets training validation sets augmented images using standard image manipulations pre trained series deep convolutional networks based open source googlenet various transformations open source imagenet non radiology images trained networks fine tuned using original augmented radiology images model highest validation accuracy applied institutional test set publicly available set accuracy assessed using youden index set binary cutoff frontal lateral classification retrospective study irb approved prior initiation network pre trained million greyscale imagenet images fine tuned augmented radiographs chosen binary classification method correctly classified test set publicly available images classification rapid images per second deep convolutional neural network created using non radiological images augmented set radiographs effective highly accurate classification chest radiograph view type feasible rapid method high throughput annotation
study aims discuss criminalization processes cultural manifestations brazilian funk especially context city porto alegre expressive representation called baile funk tuka therefore focuses political historical memory crime linked hunt samba funk current formation refractory punitive ethos proibidoes cultural manifestation thus one reach local stage semistructured interviews regulars bailes mcs lead meetings well military police responsible ostensible policing region criticism built result discourse analysis social actors focused participant intervention dialogues endows work outlines perspective getting punitive power suprise forceful dynamics inequality often prone turn prejudice stigmatization naturalized products violence social exclusion
study examined whether behavior change intervention focusing self regulatory strategies emphasizing role model support increases physical activity among insufficiently active meeting guidelines min week cancer patients ambulatory cancer patients female years breast colon cancer enrolled motivaction study week intervention counseling followed weekly phone calls pretest posttest week follow participants randomized either exercise stress management intervention active control exercise intervention emphasized self regulatory strategies action coping planning self monitoring patients also encouraged contact physically active sex role model potential exercise partner active control condition consisted coping relaxation techniques sixty seven patients remained study completed squash assessment measure perceived stress validated actigraph accelerometry patients exercise group stress management patients increased activity levels meet guidelines min week participants exercise intervention maintained exercise level also stress management patients met guidelines patients reported reductions perceived stress additional analyses comparing patients exercise group role model contact realized contact revealed contact role model significantly likely adhere recommended guidelines compared contact role model suggesting potential mobilizing role model support facilitate sum cancer patients may benefit exercise intervention emphasizing self regulation also stress management regarding reducing stress increasing
study arm muscles independent operations leading prosthetic design carried feature extraction done recorded signal investigating voluntary muscular contraction relationship different arm motions repeated factorial analysis variance anova technique implemented analyze effectiveness signal electronic design consisted analog digital signal processing controlling circuit mechanical assembly consisted wrist palm fingers grip object addition screw arrangement connected low power motor gear assembly open close hand wrist mechanically rotated orient hand direction suitable pick hold object entire set placed casing provides cosmetic appeal artificial hand connected arm design criteria include electronic control reliability light weight variable grip force ease attachment simple operations like opening grasping lifting objects different weight grip force slightly enough like natural hand
study child abuse effects conjunction witnessing domestic violence shown influence dual exposure development behavior problems children thus study goal analyze likely influence dual exposure adolescent drug use antisocial behavior sample comprised adolescents juvenile offenders foster care centers autonomous community galicia spain results showed adolescents witnessed family violence higher rates aggressive rule breaking behaviors theft substance abuse well frequent use alcohol cannabis cocaine compared youths without history family violence adolescents maltreated childhood dual victimization
study regards attitudes russian immigrants israel toward wife abuse corporal punishment sample consisted participants based multistage cluster sampling study used questionnaire related immigration acculturation attitudinal issues findings indicate dual causal model corporal punishment attitudes contribute wife abuse attitudes vice versa however effect attitudes supporting corporal punishment stronger effect wife abuse attitudes indicating attitudinal system precursor violent behavior already merging two types violence
study conducted evaluate efficacy mikania cordata leaf powder non specific immune response disease resistance labeo rohita fingerlings aphanomyces invadans infection cordata extract incorporated diets rohita fingerlings blood serum sampling carried day day day day feeding trials determine nbt levels myeloperoxidase activity phagocytic activity serum lysozyme activity compared control group fish challenged aphanomyces invadans days mortalities recorded days post infection results revealed fishes fed mikania cordata extract showed significant increase nbt levels myeloperoxidase activity phagocytic activity serum lysozyme activity compared control group dietary cordata extract showed significantly higher protection relative percentage survival rps invadans infection control results indicate cordata leaf powder stimulates non specific immunity makes rohita resistant fungal infection invadans
subject nde reliability pod gone multiple phases since humble beginning late followed several programs including important one nicknamed cracks travel short cracks lockheed georgia company air force studies ultimately led series developments field reliability pod starting introduction fracture mechanics damaged tolerant design dtd statistical framework bernes hovey pod estimation mil std hdbk last decade various groups researchers studied reliability pod using model assisted pod mapod simulation assisted pod sapod applying bayesian statistics developments one objective improving accuracy life prediction components large extent depends reliability capability nde methods therefore essential reliable detection sizing large flaws components currently pod used studying reliability capability nde methods though pod data offers absolute truth regarding nde reliability system capability effects flaw morphology quantifying human factors furthermore reliability pod reported alike meaning pod nde reliability pod subset reliability consists six phases samples selection using doe nde equipment setup calibration system measurement evaluation sme including gage repeatability reproducibility gage analysis variance anova nde system capability electronic physical saturation acquiring fitting data model data analysis pod estimation paper provides overview major pod milestones last several decades discuss rationale using integrated computational materials engineering icme mapod sapod bayesian statistics studying controllable non controllable variables including human factors estimating pod another objective list gaps hoped versus validated fielded failed hardware
success pervasive smart environments lies capacity involve visitors interact essential retail stores paper describe setting low cost system indoor localization customer interaction developed complex infrastructure wireless embedded sensors creation responsive store allows customers connect real world smart devices overcome lack ubiquity public spaces furthermore venue analytics proximity sensor possible customize user experience first describe whole sensor network deep active beacon technology adopted study thanks analytics present data evaluation aim determining best sensor arrangement according several user tests beside strong enhancement human interaction results essay demonstrate embedded localization systems could useful source data collection beside strong enhancement human interaction paper focused help retailers insiders many purposes products development improvement segmentation strategies human behaviour analyses stores embedded computing augment environment
successful use intelligent agents healthcare attracted researchers apply emerging software engineering paradigm advanced complex applications main success factor natural mapping real world medical problems cyber world multi agent architecture easily model heterogeneous distributed autonomous health care systems multi agent systems applied single healthcare activity like knowledge based medical system complex multi component based systems like complete healthcare unit use multi agent systems health care domain also opened ways find new applications like personalized socialized health care systems versatile use multi agent systems also posed new problems researchers like security communication different social issues work reviews recent years research applications multi agent systems healthcare published different research journals international conferences implemented practically reviewed five subdomains three systems subdomain set common parameters systems extracted compared analyze systems merits deficiencies based analysis provided recommendations multi agent systems applied healthcare domain future research directions interested researchers practitioners also discussed future research work intend study healthcare multi agent systems commerce
sudden impact free surface flow upon solid wall common occurrence many situations nature technology design marine structures probably obvious example also river dam hydraulics well necessity understanding flood debris flow induced damage led theoretical experimental work mechanism fluid slamming loads therefore old rich research field yet reached full maturity semi empirical methods design practice still rule many sectors date cfd technology eulerian lagrangian approaches employed investigate highly non stationary fluid impact solid wall development pressure wave produced impact examined propagates interacts fluid boundaries well subsequent build high pressure gradients high fluid velocities geometry velocity field problem considered simple results seem provide new insight particular connection phenomena different timescales
surface flow generated bubble plume technique proposed collect surface floating substances great importance handling oil layer formed large oil spill accidents due need protect naval systems rivers lakes motivation research broaden understanding oil flow stratified layer oil free surface laboratory experiments carried order investigate multi dimensional motion water oil due bubbles flow structure bubble induced convection stratified liquid investigated using particle imaging velocimetry piv measurements pathline measurements confirmed paper flow structure strongly modulated gas flow rate bubble size velocity surface flow induced bubble plume vicinity oil water interface larger stronger inside oil layer moreover surface flow particularly rapidly generated vicinity oil water interface highest kinetic energy generated far distance inside bubble plume vicinity oil water interface observation confirms idea bubble plume indeed generate strong wide surface flow bubble generation system oil layer easily broken bubbles especially high void fraction small bubble size high gas flow rates experimental results compared numerical results earlier paper confirmed paper experimental results resemble numerical results reference thermally stratified liquid liquid flow pattern bubble induced convection also measured using thermo sensitive liquid crystal tracer particles color image processing combined measure temperature field results compared immiscible stratified cases elsevier inc rights reserved
surface roughness spaghetti important factor influencing noodle quality cooking study describe novel rapid low cost method based principal object rougher surface refracts light measure surface roughness spaghetti using images acquired common digital camera method helps determine surface roughness using gray level frequency distributions transmission images facilitates measurement surface geometry accuracy traditional high performance laser scanning microscopy techniques furthermore method enables rapid measurement entire surface geometry spaghetti including steeply sloped shaded regions difficult measure conventional laser method owing lower reflectance shielding laser beam
survival developing embryos depends control maintenance homeostasis stress caused chronic immobilization pregnancy rats may alter normal development nervous system increase susceptibility psychiatric disorders investigated effects chronic stress cell proliferation forebrains embryos days gestation hippocampus dentate gyrus cortex embryos days gestation examined serial sections embryonic brains control stressed rats days gestation brain sections immunolabeled anti pcna stereological analysis performed images results showed statistical differences days gestation proliferation area structures studied whereas day gestation proliferation decreased cortex dentate gyrus embryos stressed group changes related decreased prolactin increased corticosterone concentrations plasma
switched reluctance machine srm offers advantages topologies low torque density high torque ripple use nonstandard power converter limitations paper develops drive configuration facilitates operation six phase srm using standard three phase inverter order address limitations focus paper investigation electromagnetic design aspects two candidate srm topologies six phase context pure electric hybrid electric vehicle type application advances made understanding electromagnetic design suitable srms conventional srm demonstrated preferred topology parametric finite element analysis fea design studies reference given specification laboratory test results prototype machine presented verification machine design demonstration drive concept high torque density candidate suitable electric vehicle applications
synthesis feruloyl soy glycerides demonstrated pilot scale metric ton year continuous four column series packed bed enzymatic bioreactor herein referred bioreactor ethyl ferulate soybean oil combined converted candida antarctica lipase immobilized acrylic resin novozym degrees ethyl ferulate soybean oil substrate fed four packed bed enzyme columns series column fitted recirculation pump improved conversion throughput compared smaller batch bioreactor systems synthesis carried months single charge enzyme produce feruloyl soy glycerides conversion stability feruloyl soy glycerides determined comparing total ferulate concentration absorbance free radical scavenging antioxidant capacity total acid value hydrolysis lovibond color samples produced samples produced feruloyl soy glycerides showed appreciable loss absorbing lambda max rapid antioxidant capacity reduction initial radical concentration min six years storage feruloyl soy glycerides shown hygroscopic six years show appreciable difference total acid number due hydrolysis change color successful pilot scale synthesis long term efficacy stability feruloyl soy glycerides critical adoption feruloyl soy glycerides broad range absorbing antoxidant ingredient cosmetic skin care industries published elsevier
system consisting several cascade connected electrical circuits presented paper considering system structure fact tunnel diodes nonlinear characteristics one properties system possibility chaos appearance necessary conditions sufficient condition chaos appearance nonlinear cascade connected systems given analyzed results confirmed bifurcation escape time diagrams simulation elsevier ltd rights reserved
system dynamics computer simulation modeling methodology one suitable effective ways dynamics modeling complex non linear natural technical organization systems studying dynamics behavior marine electric power systems one complex dynamic non linear technical systems requires application effective modeling methods aim paper show efficiency system dynamics computer simulation modeling dynamics behavior marine diesel drive generating set one complex non linear marine technical systems marine diesel drive generating set presented qualitative quantitative system dynamics computers model special automation aspect provided two unieg pid regulators electronics universal pid regulators one used diesel motor speed frequency regulation used synchronous electrical generator voltage regulation computer simulation model marine diesel drive synchronous generating set suitable education simulator software especially marine students marine system engineers provides means conduct numerous simulations various productive scenarios
teaching algorithms programming concepts students first years computer science course major challenge students often difficulty understanding subject leading high dropout rate institution dropout rate first year computer science course led think pedagogical strategies reduce number use learning objects gained ground higher education experiments developed help teach programming concepts students early years experiments applied use teaching programming concepts however one difficulties encountered previous experiences identify ideal moment introduce students therefore conducted new experiment two groups students using teach sorting concepts first group introduced professor started teaching theoretical concepts second group professor initially taught theoretical concepts later introduced study aims present methodology used carry experiment results achieved
techno economic feasibility retrofitting existing canadian houses solar assisted heat pump sahp investigated sahp architecture adopted previous studies conducted canadian climate system utilizes two thermal storage tanks store excess solar energy use later day control strategy defined order prioritise use solar energy space domestic hot water heating purposes due economic technical constraints series eligibility criteria introduced house qualify retrofit model built esp retrofit introduced eligible houses canadian hybrid residential end use energy ghg emissions model simulations conducted entire year estimate annual energy savings ghg emission reductions results show sahp system performance strongly affected climatic conditions auxiliary energy sources fuel mixture electricity generation energy consumption ghg emission canadian housing stock reduced eligible houses receive sahp system retrofit economic analysis indicates incentive measures likely necessary promote sahp system canadian residential market elsevier ltd rights reserved
technological advancements mobile connectivity services gprs gsm blue tooth wimax made mobile phones necessary component daily lives also mobile phones become smart let users perform routine tasks however rapid increase technology tremendous usage smartphones make vulnerable malware security breaching attacks diverse range mobile connectivity services device software platforms standards make critical look holistic picture current developments smartphone security research paper contribution twofold firstly review threats vulnerabilities attacks solutions period special focus smartphones attacks categorized two types old attack new attacks categorization aim provide easy concise view different attacks possible solutions improve smartphone security secondly critically analyze findings estimate market growth different operating systems smartphone coming years furthermore estimate malware growth forecast world
technology smart homes instance ambient assisted living technologies designed assist homes residents accomplishing daily living activities thus better quality life preserving privacy system usually equipped collection inter related software hardware components monitor living space capturing behaviour resident understanding activities system inform risky situations take actions behalf resident satisfaction present survey address technologies analysis methods bring examples state art research studies order provide background research community particular survey expose infrastructure technologies sensors communication platforms along artificial intelligence techniques used modeling recognizing activities brief overview approaches used develop human computer interfaces systems given survey also highlights challenges research trends area
teleoperation mobile social robots requires operators understand facial gestures nonverbal communication person interacting robot also critical operator comprehend surrounding environment order facilitate navigation human robot interaction allowing operator control robot gaze direction help operator observe person nonverbal communication however manually actuating gaze increases operator workload conflicts use robot camera navigation address problems authors developed teleoperation system combines automatic control robot gaze graphical representation surrounding environment location items configuration shop study robot plays role shopkeeper conducted validate effectiveness proposed gaze control technique control interface demonstrated combination automatic gaze control representations spatial relationships improved quality robot interaction customer
temporal trend inflammatory bowel disease ibd incidence reported increasing worldwide regions however reports focusing china sparse aim study provide overview disease burden clinical features ibd chinese population searched medline embase another two chinese databases parallel literature review data extraction conducted meta analysis performed estimate summary incidence rate crohn disease ulcerative colitis constituent ratios calculated clinical phenotypes classifications literature review included publications summary incidence rate ibd per person years corresponding incidence rates per person years respectively sex distribution analysis indicated male predominance sex ratio sex ratio clinical characteristics summarized using data cases cases majority patients diagnosed years age non stricturing non penetrating disease varied disease locations less extra intestinal manifestation cases featured later disease diagnosis severe disease course segmental lesions less extra intestinal manifestations study provided estimated disease burden ibd demonstrated distinct clinical features chinese population large scale population based studies needed evaluate findings
term swelling used old scriptures illustrate change normal figure expression illness noted ancient times human diseases often regarded punishment god hence surprising one oldest tests infidelity involved swelling inflicted punishment great greek physician hippocrates considered one outstanding figures history medicine father western medicine already used term oida describe swelling organs took many centuries later first description angioedema distinct medical entity minted quinke historical progression angioedema research characterized intermittent leaps interest scientific achievements example took years accurate description hereditary angioedema hae osler group researchers headed donaldson disclosed central role inhibitor angioedema pathophysiology followed result collective effort many researchers scientific groups able elucidate intricate connections implicated biochemical pathways still scientific progress hardly translated effective therapy another years elapse renewed interest hae boosted studies efficacy safety novel therapies years ago twenty first century hae ceased orphan disease future far optimistic better managed specialized angioedema centers harmonized clinical guidelines educational programs laboratory services continued basic clinical research patient associations worldwide offering support guidance governments healthcare systems gradually addressing patient family needs
term spondyloarthritis spa increasingly used classify diagnose patients characterized inflammation axial skeleton peripheral manifestations arthritis enthesitis management spa tailored according current manifestations disease disease activity functional impairment current article focuses diagnosis therapy patients axial spa diagnostic procedures discussed light diagnostic utility feasibility daily routine care cornerstones treatment patients axial spa combination regular exercise pharmacological treatment options aiming anti inflammatory strategies
term spondyloarthritis spa used describe group inflammatory autoimmune diseases including ankylosing spondylitis psoriatic arthritis common genetic risk factors clinical features spa clinically distinct rheumatoid arthritis typically affects spine sacroiliac joints entheses less commonly peripheral joints although pathogenesis spa fully understood recent findings identified interleukin pathway key mediator disease pathogenesis clinical evidence efficacy inhibition biologic agents initially shown patients chronic plaque psoriasis another autoimmune disease mediated pathway subsequently similar positive efficacy inhibition seen patients ankylosing spondylitis psoriatic arthritis inhibition may also improve cardiovascular metabolic comorbidities often found patients spa studies linked disorders pathway review examine key preclinical studies demonstrated mechanistic role development spa discuss observations translated clinical practice
test suite minimization problem tsmp hard real world problem arises field software engineering consists selecting minimal set test cases large test suite ensuring test cases selected cover given set requirements piece software time minimizes amount resources required execution paper propose systolic genetic search sgs algorithm solving tsmp sgs recently proposed optimization algorithm capable taking advantage high degree parallelism available modern gpu architectures experimental evaluation conducted large number test suites generated seven real world programs seven large test suites generated case study real world program shows sgs highly effective tsmp sgs outperforms two competitive genetic algorithms also outperforms four heuristics specially conceived problem results also show gpu implementation sgs achieved high performance obtaining large runtime reduction respect cpu implementation solutions similar quality gpu implementation sgs also shows excellent scalability behavior solving instances large number test cases consequence gpu based sgs stands state art alternative solving tsmp real world software testing environments elsevier rights reserved
textile dyeing industries major sources environmental water pollution world textile wastewater effluents discharged rivers often appear dark red purple color due azo dyes transformed carcinogenic aromatic amines chemicals used dyeing readily degraded nature thus precipitate river sediment however little known dyeing chemicals affect river sediment river water long persist difficult monitor assess undetectable dyes byproducts river sediments evaluated potential river sediment bacteria degrade dyes aromatic amines describe natural remediation river sediment long contaminated textile dyeing effluent cessation wastewater discharge dye degradation potential decreased aromatic amine degradation potential increased initially declined time changes degradation potential consistent changes sediment bacterial community transition occurred order years data strongly suggest dyes remained river sediment aromatic amines produced even transparent longer colored river water chemicals degraded changing sediment bacteria time course monitoring degradation activities key bacteria thus enables assessment fate dye pollutants river sediments elsevier ltd
therapeutic alliance demonstrated association favorable psychotherapeutic outcomes treatment eating disorders eds however questions remain inter relationships early alliance early symptom improvement treatment outcome conducted meta analysis relations among constructs possible moderators relations psychosocial treatments eds twenty studies met inclusion criteria supplied sufficient supplementary data results revealed small moderate effect sizes indicating early symptom improvement related subsequent alliance quality alliance ratings also related subsequent symptom reduction relationship early alliance treatment outcome partially accounted early symptom improvement regard moderators early alliance showed weaker associations outcome therapies strong behavioral component relative nonbehavioral therapies however alliance showed stronger relations outcome younger older patients variance shared early symptom improvement sum early symptom reduction enhances therapeutic alliance treatment outcome eds early alliance may require specific attention younger patients receiving nonbehaviorally oriented treatments
thermal performance heat exchanger important potential application integrated solar cell module thermoelectric generator teg system usually thermal performance heat exchanger tegs analysed using heat conduction theory ignores detailed phenomena associated thermo hydraulics paper thermal momentum transports two different heat exchangers simulated means steady state turbulent flow model heat conduction module various flow rates order simulate actual working conditions heat exchangers hot block electric heater included model teg module simplified using heat conduction theory thermal performance equivalent real teg natural convection effects outside surfaces computational domains considered computational models methods used validated transient thermal electrical experimental conditions teg two heat exchangers designed paper better thermal performance existing heat exchanger tegs importantly fin heat exchanger compact efficient tube heat exchanger authors published elsevier ltd
third person effect tpe hypothesis states people typically perceive media messages greater influence others though self perceptual bias shown robust across variety message contexts past research typically utilized caucasian college student samples current study addresses shortcoming literature examining whether tpe hypothesis holds low income low education spanish speaking female adults regard perceived effects health news coverage findings showed participants chose equal others estimating health news effects instead less others others results ordinal logistic regression showed propensity toward tpe related optimistic bias certain indicators acculturation findings suggest need future tpe research hispanic populations efforts investigate tpe intercultural perspective
three major hereditary cancer syndromes latinos hereditary breast ovarian cancer familial adenomatous polyposis lynch syndrome shown exhibit geographic disparities country origin suggesting admixture based disparities solid infrastructure clinical genetics geared towards diagnosis prevention could aid reducing mortality cancer syndromes latinos currently clinical cancer genetic services latin america scarce moreover limited studies investigated mutational spectrum cancer syndromes latinos resulting gaps personalized medicine affecting diagnosis treatment prevention following commentary discusses available genotype clinical information hereditary cancer latinos highlights limited access cancer genetic services latin america including barriers genetic testing alternatives providing better access genetic services review discuss status clinical genetic cancer services latinos latinos living latin america
three dimensional dynamics morphology human embryonic brain previously analyzed using modern imaging techniques morphogenesis cerebral vesicles ventricles analyzed using images derived human embryo specimens kyoto collection acquired magnetic resonance microscope equipped superconducting magnet total embryos carnegie stages without apparent morphological damage torsion brain ventricles axes studied estimate uneven development cerebral vesicles volumes whole embryo brain prosencephalon mesencephalon rhombencephalon respective ventricles measured using image analyzing amira software brain volume excluding ventricles brain tissue mean increased exponentially fold increase consistent observed morphological changes mean volume prosencephalon volume increased exponentially reached mean volumes mesencephalon rhombencephalon respectively volumes reached respectively ratio cerebellum rhombencephalon approximately increased ratio volume cerebral vesicles whole embryo remained nearly constant non uniform thickness brain tissue development may indicate differentiation brain visualized surface color mapping thickness basal regions prosencephalon rhombencephalon thicker corresponding dorsal regions brain studied serial digital subtraction layers tissue external internal surfaces visualize core region cor thickening brain tissue cor associated development nuclei became apparent particularly visible prosencephalon anatomical positions cor mostly consistent formation basal ganglia thalamus pyramidal tract confirmed comparisons serial histological sections human embryonic brain approach used study may suitable convenient alternative method estimating development differentiation neural ganglia tracts findings contribute better understanding brain cerebral ventricle development authors published elsevier inc
three membered runx gene family includes runx major mutational target human leukemias displays hallmarks tumor suppressors oncogenes mouse models runx genes appear act conditional oncogenes ectopic expression growth suppressive normal cells drives lymphoma development potently combined expressed myc loss clues underlying mechanisms emerged previously murine fibroblasts ectopic expression runx genes promotes survival direct indirect regulation key enzymes sphingolipid metabolism associated shift sphingolipid rheostat ceramide sphingosine phosphate testing relationship lymphoma cells therefore high priority find ectopic expression runx lymphoma cells consistently perturbs sphingolipid rheostat whereas essential physiological role runx revealed reduced levels normal spleen partial cre mediated excision furthermore show ectopic runx expression confers increased resistance lymphoma cells glucocorticoid mediated apoptosis elucidate mechanism cross talk glucocorticoid sphingolipid metabolism sgpp dexamethasone potently induces expression sgpp lymphoma cells drives cell death reduced partial knockdown sgpp shrna direct transcriptional repression sgpp ectopic runx together data show runx plays role regulating sphingolipid rheostat normal development perturbation cell fate regulator contributes runx driven lymphomagenesis wiley periodicals inc
timing predictability multi processor system chip mpsoc platforms hard real time applications much challenging traditional platforms due large number shared processing communication memory resources yet indispensable challenge guaranteeing safe usage safety critical domains avionics automotive article real time analysis based model checking proposed model checking based method allows guaranteeing timing bounds multiple synchronous data flow application sdfa implementations approach utilizes timed automata common semantic model represent wcet software components sdf actors shared communication resource access protocols buses dma private local shared memories mpsoc resulting network analyzed using uppaal model checker providing safe timing bounds implementation furthermore show extension previous system model enabling single beat inter processor communication style beside burst transfer style provide implementation complete set templates capturing considered system model demonstrate approach using multi phase electric motor control algorithm modeled sdfa mapped infineon tricore based aurix multicore hardware platform burst single beat inter processor communication styles approach shows significant precision improvement percentage improvement compared worst case bound calculation based pessimistic analytical upper bound delays every shared resource access addition scalability examined demonstrate analysis feasibility small parallel systems actors mapped tiles actors tiles platforms elsevier rights reserved
tiny house movement represents unique building initiative aims reduce environmental financial impacts modern living paper introduces integration tiny house competition project undergraduate construction management curriculum investigates role building information modeling bim facilitating sustainable living design construction well student learning using experiential project based pedagogy bim prevailing across global design construction industry higher education striving developing effective pedagogy cultivate students competency bim recently emphasis bim education transforming software training problem solving context project execution management therefore experiential project based learning seems promising option bim education paper highlights synergistic bim usage tiny solar house project broad student participation comprehensive inclusion lower upper division undergraduate construction management courses tiny solar house project provides desired pedagogical construct fosters active student learning engagement attaining bim knowledge developing problem solving skills bim multiple phases span inception design construction eventually occupancy operation authors published elsevier ltd
topic media violence subject heated debate recent decades vast empirical literature effects television aggression published comprehensive review ever focused studies use criminal aggression outcome present paper represents attempt fill void provide resource wish delve four decades original research order assess line investigation studies evaluated based contemporary standards research field criminology although possibility television film violence impact violent criminality remains concluded despite persistent published reviews state contrary body published empirical evidence topic establish viewing violent portrayals causes crime elsevier ltd rights reserved
toxic effects two recently discovered inhibitors selectively extraordinary strong picomolar binding affinity human carbonic anhydrase isoform investigated zebrafish embryonic development recently introduced anticancer target since highly overexpressed numerous human cancers nearly absent normal tissues morphological changes zebrafish treated compounds studied light field microscopy histological analysis homology models zebrafish built identify conserved amino acid residues active site zebrafish cas toxicity studies showed values hours post fertilization hpf ethoxzolamide eza non selective inhibitor commonly used drug clinics thus eza toxic three compounds zebrafish embryos exposed doses showed fewer phenotypic abnormalities compared embryos exposed corresponding dose eza histochemical studies show gross morphological changes embryos treated unlike eza results study indicate compounds exhibited fold lower toxicity induced fewer side effects zebrafish eza therefore exposure concentrations lead deleterious effects zebrafish embryonic development thus inhibitors may developed drugs
traditional olap line analytical processing systems store data relational databases unfortunately difficult manage big data volumes systems alternative nosql systems sql provide scalability flexibility olap system define set rules map star schemas optimization structure precomputed aggregate lattice two logical nosql models column oriented document oriented using rules analyse implement two decision support systems one model using mongodb hbase compare systems phases data generated using tpc benchmark loading lattice generation querying
traditional research information dissemination mostly based virus spreading model information spread probability match well reality information receive always less sent order quantitatively describe variations amount information spreading process article proposes safety information radiation model basis communication theory combining relevant theories complex networks model comprehensively considers various influence factors safety information radiates network introduces concepts communication theory perspective radiation gain function receiving gain function information retaining capacity information second reception capacity describe safety information radiation process nodes dynamically investigate states network nodes micro level article analyzes influence various initial conditions parameters safety information radiation new model simulation simulation reveals novel approach reflect variation safety information quantity node complex network scale free network better radiation explosive power small world network better radiation staying power results also show efficient improve overall performance network security selecting nodes high degrees information source refining simplifying information increasing information second reception capacity decreasing noises word article lays foundation research interactions information energy internal components within complex systems elsevier rights reserved
transfer nutrients mother chorioallantoic placenta meets nutritional needs embryo human prenatal development although amniotes start similar tool kit extraembryonic tissues enormous diversity extraembryonic tissue formation evolved accommodate embryological physiological constraints unique developmental programs comparative knowledge extraembryonic tissues role nutrient uptake development required fully appreciate adaptive changes placental mammals offer comparative embryological perspective propose three conserved nutrient transfer routes among amniotes highlight importance yolk sac endoderm thought vestigial remnant amniote lineage mediating nutrient uptake early human development also draw attention similarity yolk sac endoderm mediated trophectoderm mediated nutrient uptake
treatment topic puzzled researchers many years current mainstream theories still consider beta important target cure study attempted explore multiple targets treatments aim identifying qualified compound could inhibit aggregation beta block rage beta axis believed compound targets beta rage may feasible strategy treatment novel small natural compound matrine mat identified high throughput screening main components traditional chinese herbs used treat dementia various experimental techniques used evaluate effect mat two targets vitro mouse model mat could inhibit beta induced cytotoxicity suppress beta rage signaling pathway vitro additionally results vivo evaluations effects mat two targets consistent results vitro studies furthermore mat reduced proinflammatory cytokines beta deposition attenuated memory deficits transgenic mice believe novel multi target strategy inhibit beta rage worthy exploration therefore future studies focus identifying even effective multi target compounds treatment based molecular structure mat
treatment craniofacial defects present many challenges due variety tissue specific requirements complexity anatomical structures region printing technologies provide clinicians engineers scientists ability create patient specific solutions craniofacial defects currently three key strategies utilize technologies restore appearance function patients rehabilitation reconstruction regeneration rehabilitation printing used create prostheses replace cover damaged tissues reconstruction plastic surgery also leverage printing technologies create custom cutting guides fixation devices practice models implanted medical devices improve patient outcomes regeneration tissue attempts replace defects biological materials printing used create either scaffolds living cellular constructs signal tissue forming cells regenerate defect regions integrating three approaches printing technologies afford opportunity develop personalized treatment plans design driven manufacturing solutions improve aesthetic functional outcomes patients craniofacial defects
triggers onset oral diseases still poorly understood aim study characterize oral bacterial community healthy humans association nutrition oral hygiene habits release inflammatory marker gingival epithelial cells gecs without stimulation bacterial endotoxins identify possible indicator operational taxonomic units otus associated inflammatory marker status gecs healthy participants females males incubated without addition bacterial lipopolysaccharides lpss oral microbiota profiled using rrna gene targeted sequencing basal release bacterial communities characteristic healthy oral microbiota composition oral microbiota associated basal levels intake meat tea white wine sweets use chewing gum well flossing habits allergies gender body mass index additionally eight otus associated high basal levels gec response lps high basal levels low basal levels identification indicator bacteria healthy subjects high levels release importance may promising early warning indicators possible onset oral diseases
tryptophan hydroxylase tph gene considered promising genetic candidate regarding association predisposition major depressive disorder mdd local gyrification reflects early neural development cortical connectivity regarded potential neural endophenotype psychiatric disorders aimed investigate alterations cortical gyrification prefrontal cortex anterior cingulate cortex association tph polymorphism patients mdd one hundred thirteen patients mdd eighty six healthy controls underwent weighted structural magnetic resonance imaging genotyping tph local gyrification index cortical regions prefrontal cortex anterior cingulate cortex analyzed using freesurfer patients mdd showed significant hypergyria right rostral anterior cingulate cortex medial orbitofrontal cortex frontal pole significant genotype diagnosis interaction local gyrification index right rostral anterior cingulate cortex study revealed significant hypergyria anterior cingulate cortex prefrontal cortex interactive effect diagnosis mdd genotype anterior cingulate cortex might associated dysfunction neural circuits mediating emotion processing could contribute pathophysiology mdd wiley periodicals inc
two process theory psychopathy posits distinct etiological mechanisms contribute condition weakness defensive fear reactivity related affective interpersonal features impaired cognitive executive functioning marked reductions brain responses related impulsive antisocial features current study examined relations psychopathy factors electrocortical response emotional neutral pictures male offenders assessed using psychopathy checklist revised pcl impulsive antisocial features pcl factor associated reduced amplitude earlier brain response pictures regardless valence whereas affective interpersonal dimension factor associated specifically reductions late positive potential response aversive pictures findings provide support two process theory add growing body evidence linking impulsive antisocial facet psychopathy broader construct externalizing proneness findings discussed terms current initiatives directed incorporating neuroscientific concepts psychopathology classification
two stage voltage regulator module vrm structure gaining attention high end server applications llc converter preferred choice first conversion stage provides isolated output efficiently converted multi phase buck converter since cpu works sleep mode time light load efficiency important energy saving paper proposes change primary side llc converter full bridge configuration half bridge configuration dynamically light load condition output llc transformer dcx changed increase overall light load efficiency significantly due reduced core loss llc dcx reduced switching loss multiphase buck converter achieve fast transition bus voltage capacitance intermediate bus properly selected optimal trajectory control transition configuration configuration proposed high efficiency high density llc dcx designed experiments two stage vrm demonstrate fast transient response light load efficiency improvement
type war wide changed since stealth aircraft successfully manufactured technologies attack defence facing seriously situation technologies stealth anti stealth aircraft studying many developed countries paper technologies stealth aircraft shortcoming analyzed time trend stealth technology anti stealth detection discussed
convention rights persons disabilities uncrpd puts focus accessibility technology considered precondition means support full participation people today new technologies provide new options support people including people disabilities concepts assistive technology accessibility begin merge technology based accessibility tba tba potential make significant change lives people disabilities
understanding cyclic post cyclic behaviours soil geosynthetic interface essential design geosynthetic reinforced soil structures repeated loads induced traffic earthquakes compaction paper series monotonic direct shear tests cyclic direct shear integrating monotonic direct shear tests conducted using large scale direct shear testing device effect normal stresses cyclic shear amplitude cycle number post cyclic behaviour interface investigated addition influence cyclic shear interface direct shear behaviour discussed detail test results indicated peak residual shear stresses interface post cyclic shear phase increased linearly normal stress number cycles volume contraction induced direct shear decreased increase normal stress interface apparent adhesion friction angle increased cyclic shear
unique biology rna binding proteins altering view genesis protein misfolding diseases proteins use aggregation low complexity domains lcds means regulate localization utilization rna forming rna granules stress granules transport granules bodies reliance reversible aggregation mechanism biological regulation renders family proteins highly vulnerable promoting diseases protein misfolding mutations rna binding proteins associated many neurodegenerative disorders amyotrophic lateral sclerosis als frontotemporal lobar dementia ftld biology rna binding proteins also extends microtubule associated protein tau tau normally axonal protein stress translocates somatodendritic arbor takes new function promoting formation stress granules interaction tau stress granules also promotes tau aggregation accelerating formation tau pathology associate diseases alzheimer disease
united kingdom marriage sex couples act framed government equality measure opposed legislation likely sensitive possible accusations prejudice article examines opposition marriage equality within british press explores denials homophobia made opponents sex marriage attended commonsense notions homophobes either aligning views categories persons typically considered homophobic distancing views homophobic opponents also offered counter accusation liberal supporters sex marriage intolerant parallels drawn discursive literature racist discourse appears despite social scientists attempts expand concept antigay prejudice homophobia commonly referred terms irrational bigoted individuals
united nations convention rights child inspired numerous initiatives recognize children health related rights whereas children rights served dominant moral framework child health concerns europe pediatric bioethics emerged principal framework used north america despite similarities two frameworks differ significantly children rights initiatives tend universalist highlighting substantive standards children pediatric bioethics developed norms models procedures ethical analysis management individual cases aim article critically examine respective contributions intersections children rights pediatric bioethics moral frameworks child health describe collaboration bridging work two frameworks address pediatric health care concerns republic georgia conclude recommendations complementarity two frameworks bridged promoted internationally
united states geological survey estimates four trillion barrels crude oil currently trapped within oil shale reserves however cost effective environmentally sustainable method oil production oil shale currently exists given continuing demand low cost fossil fuel production alternative methods shale oil extraction needed geothermic fuel cells gfc harness heat generated high temperature solid oxide fuel cells electricity generation process oil shale sweet crude oil paper thermo electrochemical model exercised simulate performance gross geothermic fuel cell module situ oil shale processing gfc analyzed work prototype contains three solid oxide fuel cell sofc stack combustor assemblies packaged within diameter tall stainless steel housing high temperature process heat produced sofcs electricity generation used retort oil shale within underground geological formations high value shale oil natural gas steady state system model developed aspen plus using user defined subroutines predict stack electrochemical performance heat rejection module model validated empirical data independent single stack performance testing full gfc module experiments following model validation simulations performed different values current fuel air utilization study influence system electrical heating performance model used explore wider range operating conditions experimentally tested provides insight competing physical processes play geothermic fuel cell operation results show operating conditions tuned generate desired heat flux conditions needed across applications elsevier ltd rights reserved
united states supreme court recent decision relating violent video games revealed divisions within scientific community potential negative effects games well need higher quality research scholars also debated potential violent games positive effects visuospatial cognition math ability current study sought extend previous literature using well validated clinical outcome measures relevant constructs generally lacking past research cross section data aggression visuospatial cognition math achievement available sample female mostly hispanic youth mean age prospective year data aggression school gpa available female youth results sets analysis revealed exposure violent game neither short term long term predictive influences either positive negative outcomes developmental analysis cross sectional data revealed results differ across age categories older children preadolescents adolescents analysis effect sizes largely ruled type error possible explanation null results suggestions new directions field video game research proffered
united states new executive orders proposed president may quickly lose greatness serving emma lazarus untimely portrait immigrants refugees tired poor huddled masses yearning breathe free years progress improving health care access underserved populations new executive orders threaten nation advancements health equity within perspective offer examples actions may result damaging impacts patients families communities health care workforce add voices myriad national leaders advocating preservation affordable care act aca protection immigrants including deferred action childhood arrivals daca
usa little known local variation retail cigarette prices price variation explained taxes bans area level socio demographics whether taxes hospitality bans synergistic effects smoking prevalence cigarette prices chain supermarkets drug stores linked state taxes state county bar restaurant smoking bans census block group socio demographics hierarchical models explored effects taxes bans retail cigarette prices well county smoking prevalence daily non daily wide variation store level cigarette prices part due differences state excise taxes excise taxes partially passed onto consumers adjustment tax associated increase price pass slightly higher areas bans differ area level socio demographics bans associated slight increase cigarette price adjustment per pack taxes bans associated reduction smoking prevalence taxes stronger association combined bans suggesting synergistic effect given wide variation store level prices uneven state county implementation taxes bans federal policies considered
usage fuel cell range extender full electric vehicle fev convenient solution address issue shortage range type vehicles compared internal combustion engine range extender ice fuel cell range extender potential provide power higher efficiency allow zero emissions operation vehicle even board power source switched range extension work introduction new pemfc high temperature proton exchange membrane fuel cell developed framework collaborative european project artemis automotive pemfc range extender high temperature improved meas stacks light duty full electric commercial vehicle investigated firstly model full electric vehicle created validated means experimental tests carried rolling chassis dyno type approval real world driving cycles model developed effects introduction pemfc vehicle range evaluated performances different pem fuel cell stack systems combined various hydrogen storage system configurations compared hydrogen energy publications llc published elsevier ltd rights reserved
use infrared sensor new alternative measure position function time kinematic experiments investigated using microcontroller data acquisition control device versatile sensors offer advantages typical ultrasound devices setup described paper enables students develop experiments promoting opportunities learning physical concepts different types forces act body gravitational elastic drag etc resulting types movements good sensitivity within range proof concept also present application prototype designed record kinematics mass spring systems
use biologic treatment strategies nonoperative operative care orthopaedic sports injuries continues expand parallel understanding healing response injuries large part growing number basic translational clinical studies investigating use biologic augmentation musculoskeletal care platelet rich plasma growth factors cell based gene based treatments among commonly explored options found varying levels success promoting soft tissue osseous healing preclinical studies illustrated potential broad application biologic treatment strategies orthopaedics however many important questions remain regarding delivery efficacy safety biologic treatments additional well designed basic clinical studies paramount importance create evidence based guidelines implementation biologic treatments orthopaedics elsevier inc rights reserved
use computer programming spread schools worldwide last century disappeared educational landscape early development visual programming languages scratch movement emerged recent years teachers educational levels different disciplines consider use programming enhances learning many subjects allows students develop important skills systematic literature review presented article aims summarize results recent research using programming scratch subjects related computing communications well studies analyzing kind skills students develop learning code environment although analyzed papers provide promising results regarding use programming educational resource review highlights need conduct empirical research classrooms using larger samples students allow obtain clear conclusions types learning could enhanced programming
use convex relaxations lately gained considerable interest power systems relaxations play major role providing quality guarantees non convex optimization problems optimal power flow opf problem semidefinite programming sdp relaxation known produce tight lower bounds unfortunately sdp solvers still suffer lack scalability work introduce exact reformulation sdp relaxation formed set polynomial constraints defined space real variables new constraints seen cuts strengthening weaker second order cone relaxations generated lazy iterative fashion new formulation handled standard nonlinear programming solvers enjoying better stability computational efficiency new approach benefits recent results tree decomposition methods reducing dimension underlying sdp matrices side result present formulation kirchhoff voltage law sdp space reveal existing link cycle constraints original sdp relaxation three dimensional matrices preliminary results show significant gain computational efficiency compared standard sdp solver approach
use data acquisition system daq important process industry enables analog signal physical system converted digital signal processing computer vice versa however many daqs available market today complex expensive paper presents development simple low cost open source microcontroller based daq system process automation control proposed daq system built around arduino mega microcontroller test experimental results developed daq system proved suitability application process monitoring control applications
use embedded computational capabilities devices magnetostrictive materials allows design objects able show smart features without use external controllers devices however magnetostrictive devices world problem getting smart performances actuation sensing lower cost faced times date paper present compensation hysteresis magnetostrictive actuator using low cost arduino platform fixed point mathematic case quasi linear actuator obtained experimental performances compared ones standard xpctarget matlab environment floating point mathematic found arduino solution largely acceptable dealing compensation errors within percents fast enough compensation times sampling frequencies kilohertz
use kaolin calcined kaolin metakaolin manufacture geopolymer attracted worldwide interests aim paper present overview progress geopolymer research development china last years works geopolymerisation mechanisms microstructure development properties application development geopolymers green building material thermal resistant material advanced inorganic composites ceramics reviewed works published many chinese made significant contribution progress geopolymer science technology whole global view latest experimental results efflorescence phase transformation discussed two key issues regarding application based geopolymers elsevier rights reserved
use modern communication information technology health sector ehealth rapidly expanding ehealth applications commonly referred ementalhealth also increasingly used psychiatric psychotherapeutic health care despite empirical evidence supporting effectiveness ehealth applications symptom reduction areas depression anxiety disorders substance dependence doubts whether ehealth applications implemented treatment psychotic disorders specific symptoms cognitive impairment may hinder proper handling applications notwithstanding concerns promising projects especially developed patients psychotic disorders context article introduce broad spectrum areas application ehealth patients psychotic disorders way four examples specific applications smartphone application focus aims increase self management psychotic symptoms psylog another smartphone application seeks improve communication medication induced side effects patient practitioner logging adverse side effects itareps uses text messaging systems sms concentrates relapse prevention avatar therapy focuses specific treatment auditory hallucinations first studies imply ementalhealth applications feasible option also psychotic patients patients rate acceptance high research needed investigate efficacy ementalhealth applications treatment psychotic disorders find solutions problems implementation meeting costs medical insurances
use nanofluids working fluid systems converting solar thermal energy led remarkable progresses study investigated thermo optical characteristics nanofluids containing graphene oxide nanoplatelets deionized water working fluid low temperature direct absorption solar collectors dascs prepared samples nanofluid contain graphene oxide nanoplatelets based deionized water weight percentages results show applied nanofluid suitable ability compared base fluid absorbing solar energy ranging also results calculation absorbed energy fraction suggest minimum height thickness nanofluid layer ability full sun energy nanofluid weight percentage height ability absorbing energy thermal conductivity coefficient prepared samples measured temperature ranging results showed increasing weight percentage nanofluid along increase temperature would improve nanofluid thermal properties comparison base fluid finally investigating impact weight percentage nanofluid temperature radiative properties thermal conductivity nanofluid strong absorption band range nanometers introduced proposed appropriate environment using direct absorption solar collectors
use oral anticoagulation oac elderly population atrial fibrillation treated long term care ltc facilities inconsistent examined magnitude sources gap indicated prescribed oac elderly population retrospectively scanned electronic medical record emr pharmacy data ltc facilities ontario canada diagnosis drawn emr different attributable risk factors possible failure prescribe oac examined total active resident data examined ltc facilities residents years old mean age years female identified residents mean age years mean chads score residents oac therapy residents mostly treated warfarin rivaroxaban apixaban followed dabigatran antiplatelet drugs stroke prevention therapy used residents residents anticoagulation antiplatelet drugs seventy two residents antiplatelet antithrombotic therapy none potential attributable risks identified consistently correlated failure prescribe indicated therapy data set suggests eligible elderly ltc residents failed receive recommended stroke prevention therapies
use violent video games often linked increase aggressive behavior according general aggression model one central mechanisms aggressiveness inducing impact emotional desensitization process resulting long lasting repeated violent game playing desensitization evidence lack empathy recent research focused primarily acute short term impact violent media use little known long term effects study excessive users violent games control subjects matched age education viewed pictures depicting emotional neutral situations without social interaction fmri activations obtained typical pattern activations empathy theory mind networks seen groups showed differences brain responses interpret results evidence desensitization hypothesis suggest impact violent media emotional processing may rather acute short lived
use virtual prototypes digital models containing thousands individual objects commonplace complex industrial applications like cooperative design huge ships designers interested selecting editing specific sets objects interactive inspection sessions however supported standard visualization systems huge models paper discuss detail concept rendering front multiresolution trees properties algorithms construct hierarchy efficiently render applied complex cad models model structure identities objects preserved also propose algorithm interactive inspection huge models uses rendering budget supports selection individual objects sets objects displacement selected objects real time collision detection displacements solution based analysis several existing view dependent visualization schemes uses hybrid multiresolution tree mixes layers exact geometry simplified models impostors together time critical view dependent algorithm constrained front algorithm successfully tested real industrial environments models involved presented discussed paper elsevier ltd rights reserved
usefulness online hybrid delivery methods education long realized advancement computer communication technologies web based authoring tools effectiveness extended point online hybrid course offerings undergraduates quickly becoming integrated regular part engineering departments course offerings many institutions offering online courses part regular schedule paper based experience started hybrid delivery ultimately extended full online offering present set recommended steps used guide interested designing online introductory computer programming course present set observations feel needs considered discussed research community paper include examples students comments received teaching evaluations hybrid online offerings
validity joint attention assessment school aged children asd unclear lord jones journal child psychology psychiatry study examined feasibility validity parent report measure joint attention related behaviors verbal children adolescents asd fifty two children asd controls assessed childhood joint attention rating scale jars jars exhibited internally consistency alpha one factor explained scale variance factor scores correctly identified children asd controls scores correlated ados parent report symptom measures jars appears assess unique dimension social phenotype children asd
variations metabolic profile latex wild growing euphorbia palustris carried using multivariate analysis nmr spectral data one population infected fungi fusarium sporotrichioides fusarium proliferatum alternaria alternata consisted healthy plant species non polar metabolites latex extracts benzoyl ingenol laurate amyrin decadienoate esters cis polyisoprene methylenecycloartanol identified using nmr spectra principal component analysis nmr data provided clear discrimination latex infected healthy plants minimum inhibitory concentration minimum fungicidal concentration values latex extracts healthy infected plants determined latex infected plants found contain higher levels benzoyl ingenol laurate methylenecycloartanol concentrations strongly correlated antifungal activities latex elsevier ltd rights reserved
visibility retinal microvasculature optical coherence tomography angiography oct images negatively affected small dimension capillaries pulsatile blood flow motion artifacts serial acquisition time averaging multiple oct images enhance definition capillaries result repeatable consistent visualization demonstrate automated method registration averaging serially acquired oct images ten oct volumes six normal control subjects acquired using prototype swept source oct system volumes divided microsaccade free face angiogram strips affine registered using scale invariant feature transform keypoints followed nonrigid registration pixel wise local neighborhood matching resulting averaged images presented retinal layers combined well superficial deep plexus layers separately contrast noise ratio signal noise ratio angiograms retinal layers reported average standard deviation increased single image respectively serially acquired images registration averaging improved visualization capillaries enable robust quantification study minute changes retinal microvasculature authors published spie creative commons attribution unported license
voltage differencing transconductance amplifier vdta recently introduced active element analog signal processing however realization vdta given author yet work new simple cmos realization vdta presented proposed block two voltage inputs two kinds current output functional voltage transconductance mode operation furthermore vdta exhibits two different values transconductance need external resistors vdta based applications seems good advantage analog circuit designer cmos implementation vdta voltage mode vdta based filter proposed simulated application example fourth order flat band band pass amplifier given performance circuit demonstrated comparing theory simulation
volume data generated modern astronomical telescopes extremely large rapidly growing however current high performance data processing architectures frameworks well suited astronomers limitations programming difficulties paper therefore present opencluster open source distributed computing framework support rapidly developing high performance processing pipelines astronomical big data first detail opencluster design principles implementations present apis facilitated framework demonstrate case opencluster used resolve complex data processing problems developing pipeline mingantu ultrawide spectral radioheliograph finally present opencluster performance evaluation overall opencluster provides high fault tolerance simple programming interfaces also flexible means scaling number interacting entities opencluster thereby provides easily integrated distributed computing framework quickly developing high performance data processing system astronomical telescopes significantly reducing software development expenses
water cooled ceramic breeder blanket wccb researched chinese fusion engineering test reactor cfetr thermal hydraulic analysis essential blanket remove high heat flux plasma volumetric heat generated neutrons paper detailed three dimensional thermal hydraulic analysis whole module wccb blanket performed computational fluid dynamics cfd method capable solving conjugate heat transfer solid structure fluid main results including temperature field distribution mass flow rate coolant pressure drop calculated simultaneously provides beneficial guidance data structural optimization design arrangement primary secondary circuit total heat source coolant mass flow rate required make coolant water corresponding pressurized water reactor pwr condition mpa degrees degrees generating total coolant pressure drop delta mpa results show present structural design make materials effectively cooled allowable temperature range except small modifications sides main components including first wall cooling plates cps side wall sws stiffening plates sps manifold dominate total pressure drop respectively additionally mass flow rate channel obtained showing peak relative deviation average paratactic channels components separately generally results indicate present design wccb blanket meet requirements thermal hydraulics elsevier rights reserved
water energy nexus increasingly studied order elucidate complex interdependence water energy resources result enhance management practices conserve resources alike context integrated water management plans direct implications energy embodied water sewerage services objective study assess potential energy savings water sewerage services means site integrated water sewage management strategies low income households florianopolis brazil studied water efficient measures include installation water efficient fixtures dual flush toilets water efficient taps reclamation grey water shower washing basin laundry toilet flushing iii rainwater use laundry toilet flushing combination measures water energy saving potential seven integrated water sewage management strategies studied moreover water consumption pattern ten low income households conventional water efficient taps empirically determined using water smart meters whereas rainwater supply capacity estimated using computer programme netuno grey water supply sewage reduction capacities determined using model equations rainwater harvesting alone appeared least favourable strategy energy savings energy consumption would increase compared centralised system combination water efficient fixtures grey water reclamation gave rise greatest energy saving potential findings study indicate energy management point view sustainability water sector primarily associated reduction effluents centralised systems rather use alternative water sources elsevier ltd rights reserved
well defined one dimensional cds mos core shell nanowires constructed employing cds nanowires cds nws nanobuilding blocks via facile hydrothermal strategy synergistic interaction stemming large intimate coaxial interfacial contact mos thin shell cds core efficiently retard charge carrier recombination mos noble metal free cocatalyst enriches active sites evolution water consequently comparison bare cds nanowires resultant core shell composite exhibits distinctly enhanced visible light activity evolution notably activity optimized mos exceeds pure cds cds composite factor times respectively identical reaction conditions apparent quantum yield reaches work provides simple paradigm facile finely controlled synthesis well shaped based composite photocatalysts towards boosted solar energy conversion elsevier rights reserved
wendelstein modular advanced stellarator commissioning phase max planck institute plasma physics greifswald germany focus numerical analysis shifted support machine design assembly towards preparation commissioning steps assessment possible field disturbances operational loads exploration operational limits paper emphasizes development evolution realization new analysis strategies well implemented numerical approaches electromagnetic thermal structural analyses remarkable results first comparisons measurements extended mechanical instrumentation system obtained evacuation flooding cryostat first cool magnet system also first part superconducting coil groups commissioning presented detail finally lessons learned transition phase highlighted might relevant large fusion machines
widely used instantaneous unit hydrograph iuh based nash cascade reservoir model obtained zero initial condition equivalently empty reservoir assumption study general case non zero initial condition considered derivation classical nash model generalized nash model gnm deduced using laplace transform principle mathematical induction river flow routing gnm physically interprets formation downstream outflow summation recession flow initial channel storage response upstream inflow gnm written state space representation able update state river system time hence applied real time forecasting two separate case studies used illustration indicated proposed updating procedure results improved river flow forecasts compared traditional iuh method elsevier rights reserved
wiener hopf factorization complex function arises variety fields applied mathematics probability finance insurance queuing theory radio engineering fluid mechanics factorization fully characterizes distribution functionals random walk levy process maximum minimum hitting times propose constructive procedure computation wiener hopf factors valid single double barriers based combined use hilbert transform numerical implementation simply performed via fast fourier transform euler summation given information wiener hopf factors strictly related distributions first passage times concrete application mathematical finance consider pricing discretely monitored exotic options lookback barrier options underlying price evolves according exponential levy process show computational cost procedure independent number monitoring dates error decays exponentially number grid points elsevier rights reserved
wireless local area network wlan communication rapidly growing approach data sharing wireless network provides network access mobile devices benefits wlan like flexibility mobility portability imposes performance security requirements communication brings new network security threats physical security wireless networks impossible wireless network signals unidirectional proceed intended coverage area intruder apt wireless receiver snoop network still remaining virtually undetected wlan important security apprehension presence rogue access point rap raps definitely used persons inadequate security knowledge security threats require advanced technical knowledge expensive intrusion devices rap wireless installed secure wireless network without network administrator permission rap allows intruder man middle mitm attack existence rap causes security threats wlan access point popular features like mobility scalability cost effectiveness ease installation airtight report shows lack knowledge secure wireless network causes number security threats
wistar kyoto rat wky model suggested model adult adolescent depression though face predictive construct validities model depression remain equivocal suitability wky diathesis model tests double hit hypothesis particularly critical periods brain behavioural development remains established effects post weaning social isolation assessed early adolescence similar pnd behavioural despair learned helplessness forced swim test fst plasma corticosterone levels tissue monoamine concentrations brain areas critically involved depression prefrontal cortex nucleus accumbens striatum hippocampus significantly increased immobility fst observed socially isolated adolescent wky concomitant increase corticosterone levels fst induced stress wky also demonstrated significantly increased release utilization dopamine manifested levels metabolites dihydroxyphenylacetic acid homovanillic acid nucleus accumbens indicating large dopamine storage pool evident adolescence induces greater dopamine release stimulated serotonin metabolite hydroxy indoleacetic acid also significantly increased nucleus accumbens indicating increased utilization serotonin along norepinephrine levels also signficantly elevated socially isolated adolescent wky differences neurochemistry suggest social environmental stimuli critical periods brain behavioural development determine developmental trajectories implicated pathways
work includes using brushless direct current motor ventilator machine fills container methane sensor researched main issue choose best controlling method implement self made driver motor
work contractors mainly comes bidding strategy take main process construction project life cycle also important part discussed construction management field case study considers economic environment changes objectively uses economic analysis financial management subjectively evaluates utility function get optimal return rate bid price maximum expected utility increasing interest rate inflation rate reinvestment rate economic environment variables help decision makers make suitable competitive bidding decision
works richard wagner celebrated impact progressive elements european culture bridge romanticism modernism france influence wagner symbolist writers artists musicians sympathetic emerged particularly significant also conservative response wagner received much less attention scholarly literature filiation exemplified figure alberic magnard opera berenice claimed influenced classical wagner article considers classicism berenice composer several perspectives portrayals temperament demonstrate consonance classical precepts political readings emphasize classical values legacy french theater seventeenth century strategies tonal organization motivic development related german symphony extending back beethoven
workshop aims show methods used developing transversal skill generator assessment game objectives enhancing digital integration learning teaching training youth work various levels promoting entrepreneurship education social entrepreneurship among young people workshop describes steps developing ict based education tool simulating real life situations order support apprentices vet students enhance foster transversal skills needed current labour market score system embedded within learning tool instead provide structure assessment skills developed due current labour market changes clear tendency towards broadening required skills portfolio occupational levels linked non routine tasks example ict professionals develop skills marketing management services workers develop customer oriented skills digital literacy tourism services professionals look new ways attract interest potential clients many knowledge intensive sectors skills managerial scientific knowledge fact frequently needed reflects growing demand employers transversal key competences personal attributes enhance individual interactions job performance career prospects transversal skills crucial employees well many youngsters choosing self employment alternative option regular employment young people still education training yet acquired necessary knowledge experiences skills needed decide whether self employment suitable future career hard skills include job specific knowledge transversal skills relate person ability interact effectively workers customers broadly applicable outside workplace problem solving analytical skills self management communication skills stress management skills beside regular entrepreneurial courses focused economy business planning financial management etc crucial young people develop transversal skills promoting ones creativity innovativeness ability work team communication skills output learning product run within moodle learning platform lms providing infrastructure mooc
world health organization centers disease control prevention cdc provide recommendations use emergency contraceptive pills ecps including levonorgestrel lng combined oral contraceptives cocs new ecp formulation ulipristal acetate upa available worldwide determine whether lng upa coc yuzpe ecps safe women certain characteristics medical conditions searched pubmed cochrane databases articles published date inception may pertaining safety lng upa yuzpe ecp use direct evidence considered studies looked safety outcomes among women certain medical conditions characteristics taking ecps compared women taking ecps indirect evidence considered studies reported pharmacokinetic data ecp use among women certain medical conditions characteristics studies reported safety outcomes among healthy women taking ecps five studies provided direct evidence five studies four examined lng yuzpe use among pregnant breastfeeding women one reported risk ectopic pregnancy among women repeatedly using lng ecps poor pregnancy outcomes rare among pregnant women used lng yuzpe ecps conception cycle early pregnancy breastfeeding outcomes differ women exposed lng ecp unexposed increased risk ectopic pregnancy versus intrauterine pregnancy repeated use lng ecps compared nonuse forty five studies provided indirect evidence one study demonstrated lng passes breastmilk minimal quantities addition nine studies examined pregnancy outcomes following ecp failure among healthy women articles reported adverse events studies suggest serious adverse events rare among women taking ecp formulations implications evidence safety ecps among women characteristics medical conditions listed within cdc family planning guidance limited however direct indirect evidence study question suggest special safety concerns use ecps among women particular medical conditions personal characteristics pregnancy lactation frequent ecp use published elsevier inc
writers propose successive improved dynamic programming sidp algorithm hydropower reservoir operation based analysis concavity complementarity monotonicity hydropower problems single period hydropower generation storage release diminishing marginal contributions hydropower generation concavity also complementary effect storage release release becomes productive accordance increasing storage multiple period hydropower generation complementarity influences concavity objective function monotonicity operation decisions major cause complexity hydropower operation mathematical derivations writers propose concave approximation hydropower generation function sidp algorithm hydropower reservoir operation efficiency sidp demonstrated two hypothetical case studies long term hydropower scheduling shows computation time sidp increases linearly accordance number storage intervals whereas dynamic programming shows quadratic increase
chromosome played critical role development sexually selected characteristics million years time accumulated disproportionate number genes concerned mental functions relatively specific effects linked genes social cognition language emotional regulation visuospatial numerical skills many human linked genes outside pairing pseudoautosomal regions escape inactivation dosage differences expression genes constitute least total likely play important role male female neural differentiation cognitive deficits behavioral characteristics particularly realm social communication associated sex chromosome aneuploidies wiley periodicals inc
theoretical knowledge theoretically oriented study materials always great advantage education universities however access learning materials know used industrial practice limited regard issue faculty mechanical engineering university west bohemia launched project example projects practice worked outputs projects learning pdf files study materials contain important information designer normally comes contact practice tender dossiers interactive models drawings processes welding machining assembly one projects focused curing press used closer examination developed study materials authors published elsevier ltd
theoretical perspectives posit heart rate variability hrv reflects self regulatory capacity therefore employed bio marker top self regulation ability regulate behavioral cognitive emotional processes however existing findings relations self regulation hrv indices mixed clarify nature relations conducted meta analysis studies reporting relations hrv indices aspects top self regulation executive functioning emotion regulation effortful control significant albeit small effect observed greater hrv related better top self regulation differences relations negligible across aspects self regulation self regulation measurement methods hrv computational techniques risk compared healthy samples context hrv measurement stronger relations observed older relative younger samples published compared unpublished studies findings generally support notion hrv indices tentatively employed bio markers top self regulation conceptual theoretical implications critical gaps current knowledge addressed future work discussed elsevier ltd rights reserved
theories race relations shaped concept racial hierarchy along whites advantaged african americans disadvantaged however recent precipitated growth latinos asian americans united states underscores need framework integrates groups current work proposes racial ethnic minority groups disadvantaged along distinct dimensions perceived inferiority perceived cultural foreignness largest groups united states located discrete quadrants whites perceived treated superior american african americans inferior relatively american compared latinos asian americans latinos inferior foreign asian americans foreign relatively superior compared african americans latinos support racial position model first obtained targets perspectives different groups experience distinct patterns racial prejudice predicted dimensional group positions studies perceivers perspectives group positions reflected content racial stereotypes study well known consensually recognized study implications new model studying contemporary race relations prejudice threat interminority dynamics discussed
theory research identify emotion dysregulation one primary mechanisms underlying borderline personality disorder bpd related pathology yet despite extensive research documenting association emotion dysregulation bpd many questions regarding precise role emotion dysregulation development treatment bpd associated difficulties remain unanswered paper reviews extant literature role emotion dysregulation bpd associated difficulties well treatment bpd related pathology identifies important next steps future research area particular review highlights need research examining dimensions emotion dysregulation unique bpd role nature interpersonal intrapersonal emotion regulation bpd role emotion dysregulation physical mental health problems associated bpd role emotion regulation efficacious treatments bpd research potential elucidate precise emotion regulation deficits relevant central bpd active ingredients mechanisms change current efficacious treatments bpd effective efficient targets integrative treatments population
number models coupled oscillator networks question stability fixed points reduces calculating index graph laplacian examples models include kuramoto kuramoto sakaguchi equations well swing equations govern behavior generators coupled electrical network show index calculation related dual calculation done first homology group graph rather vertex space also show representation computationally attractive relatively sparse graphs dimension first homology group low true many applications also give explicit formulae dimension unstable manifold phase locked solution graphs containing one two loops application present novel results kuramoto model defined ring compute longest possible edge length stable solution
hundred textile industries turkey discharge large quantities dye rich wastewater resulting water pollution effluents must treated meet discharge limits imposed water framework directive turkey industrial treatment facilities must required monitor operations keep cost effective prevent operational faults discharge limit infringements water pollution paper proposes treatment actual textile wastewater vertical flow constructed wetland vfcw systems operation monitoring effluent wastewater quality using fuzzy logic graphical user interface treatment performance vfcw investigated terms chemical oxygen demand ammonium nitrogen content color parameters day period operation computer program developed fuzzy logic system decision making tool graphically present via status analysis chart quality treated textile effluent relation turkish water pollution control regulation fuzzy logic used evaluation data obtained vfcw systems notification critical states exceeding discharge limits creates warning chart reports errors encountered reactor collection sample concerned party
significant levels concern relevance difficulty learning issues strength materials structural analysis students continuum mechanics structural analysis civil engineering usually point key learning aspects especially difficult acquiring specific skills key concepts entail comprehension difficulties ease access applicability structural analysis advanced subjects likewise elusive basic structural concepts flexibility stiffness influence lines paramount developing skills required advanced structural design tall buildings arch type structures well bridges new curricular itineraries currently implemented appears appropriate devise repository interactive web based applications training basic concepts hopefully train student understand complexity concepts develop intuitive knowledge actual structural response improve preparation exams work web based learning assistant system influence lines continuous beams presented consists collection interactive user friendly applications accessible via web performed spanish english languages rather black box system procedure involves open interaction student simulate virtually envisage structural response system performed set web pages encompasses interactive exercises problems written javascript jquery dygraphs frameworks given efficiency graphic capabilities renowned students freely boost self study subject order face exams confidently besides collection expected added virtual lab continuum mechanics upm launched http serviciosgate upm laboratoriosvirtuales laboratorios medioscontinuos construcci
quasi tridiagonal system linear equations arising numerical simulations solving algorithms encounter great challenge solving quasi tridiagonal system linear equations millions dimensions scale problems increases present solving method mixes direct iterative methods method needs less storage space computing process quasi tridiagonal matrix split tridiagonal matrix sparse matrix using method tridiagonal equation solved direct methods iteration processes approximate solutions obtained direct methods closer exact solutions convergence speed solving quasi tridiagonal system linear equations improved furthermore present improved cyclic reduction algorithm using partition strategy solve tridiagonal equations gpu intermediate data computing stored shared memory significantly reduce latency memory access according experiments test cases average number iterations reduced significantly using method compared jacobi gmres bicg respectively close bicgstab bicrstab tfqmr parallel mode parallel computing efficiency method raised partition strategy performance using method better commonly used iterative direct methods less amount calculation iteration
various methods identification duplicate records besides importance methods quality choice similarity measures important data comparison used methods four kinds similarity measures tested analysed paper identify duplicate records relational databases basis obtained results paper gives conclusions recommendations research area
growing demand using multi function inverters grid connected systems applied nonconventional energy sources solar wind addition power quality conditioning inverter also used bidirectional active power exchange three phase four wire grid therefore inverter acts multi function compensator functions proposed inverter system include active power injection rectification active power filtering apf including phase power balancing paper presents design implementation three leg split capacitor shunt multi function inverter division summation sigma digital control adopted sigma digital control accommodate filter inductance variation reducing core size significantly control laws derived directly cancel variation effects bus voltage switching period filter inductance average power method adopted paper determining fundamental currents source side design implementation inductances corresponding various inductor currents estimated startup stored microcontroller scheduling loop gain cycle cycle insure system stability measured results three phase four wire inverter confirmed analysis discussion
long standing interest assessment neurobehavioral integrity newborn infant nicu network neurobehavioral scale nnns developed assessment risk infant infants increased risk poor developmental outcome insults prenatal development substance exposure prematurity factors poverty poor nutrition lack prenatal care adverse effects intrauterine environment affect developing fetus nnns assesses full range infant neurobehavioral performance including neurological integrity behavioral functioning signs stress abstinence nnns noninvasive neonatal assessment tool demonstrated validity predictor medical outcomes cerebral palsy diagnosis neurological abnormalities diseases risks brain also developmental outcomes mental motor functioning behavior problems school readiness nnns identify infants high risk abnormal developmental outcome important clinical tool enables medical researchers health practitioners identify infants develop intervention programs optimize development infants early possible video shows nnns procedures shows examples normal abnormal performance various clinical populations exam used
radical transformation provision adult residential nursing home care england past four decades adult residential care provided public sector today public sector facilities account available places rest provided mixture profit firms non profit charities public sector role often purchaser paying fees people unable afford regulator idea private companies may play bigger role future provision health care highly contentious transformation residential nursing home care attracted little comment concerns quality care emerge time time often stimulated high profile media investigations scandals criminal prosecutions little evidence whether transformation sector largely public private provision beneficial effect need service study asks whether differences quality care provided public non profit profit facilities england use data care quality homes provided industry regulator england care quality commission cqc data results inspections carried april october controlling range facility characteristics age size proportional odds logistic regression showed profit facilities lower cqc quality ratings public non profit providers range measures including safety effectiveness respect meeting needs leadership discuss implications results ongoing debates role profit providers health social care elsevier ltd rights reserved
recent trend construct addiction applied sexual behaviours growing number people recounting excessive sexual thoughts behaviours categorized suffering sex addiction sex addiction said involve pathological relationship sex symptomology akin drug dependence opposing interpretations argued sex addiction used stigmatizing label deviate socially constructed sexual standard foucauldian form discourse analysis used analyse semi structured interviews nine men identified sex addicts highly sexual though addicted sex analysis explores sexual addiction constructed interviewees focuses discursive theme losing control used interviewees construct positioning moral status socio political ideological connotations loss control constructed using psychological biomedical discourses illness vulnerability stress turn produce implications requisite treatment societal intervention
extensive research field building modelling adaptive increasingly predictive control inclusion predictive control building energy management control systems shifts calculation optimum control strategies future allows prompt evaluation various control scenarios energy saving potential based demand controlled ventilation well established although several studies investigated potential incorporating building energy indoor air quality management cases applications reactive rather predictive incorporating concentration factor predictive models may unlock optimisation opportunities controller applications especially buildings highly varied occupancy institutional buildings objective study investigate potential creating predictive models tailored specific spaces order estimate future concentrations purpose measured simulated data combined simulated data provided detailed building model final identified model concentration state space representation derived prediction error minimisation method results suggest indeed potential least short term prediction using simple identification procedure elsevier rights reserved
much discussion past years social workers england respond cases child neglect calls take children care speed process towards adoption article argued current dominant discourse framed terms individual pathology disregards substantial body knowledge effects poverty complex interrelationships poverty neglect perpetuates blaming parents ultimately fails serve interests promote rights many children families drawing capability approach work lister article concludes initial exploration development sophisticated multidimensional analysis poverty parenting incorporates psychological social causes ways challenge polarisation debate poverty neglect
growing concern overinvolved helicopter parenting may negative consequences college students well academic achievement goal study examine effects helicopter parenting constructs related academic achievement success motivation learning perfectionism entitlement survey data presented college students mothers children report maternal helicopter parenting related extrinsic motivation learn perfectionistic discrepancy avoidance goals learning associated lower academic performance prior research mother report helicopter parenting related children sense entitlement study suggests helicopter parenting related maladaptive academic motivations may negative implications academic achievement
growing demand green building products within united states increased demand interest green products potential exists wood product manufacturers gain additional market share opportunities within green building sector overall objective study use spatial analysis techniques evaluate growth green building projects use certified wood products cwps within projects focus study green building projects certified part green building council usgbc leadership energy environmental design leed obtained certified wood credit using spatial analysis techniques study able identify geographic areas wood products used awarded points toward green building certification results indicated trend commercial leed certified projects obtained certified wood credit geographically concentrated time study also identified various hot spot county clusters throughout united states commercial leed certified projects obtained certified wood materials spatial econometric regression analysis resulted significant explanatory variables population county obtaining leed credits material reuse recycled material content composite wood agrifiber products regional material density forest stewardship council fsc certified product manufacturers within results study expected help improve availability wood products indicating potential green building marketing regions wood product producers
growing interest english speaking jurisdictions including australia north america canada united kingdom new zealand prevention sexual abuse perpetrated children children aim review identify opportunities research policy practice could enhance prevention agenda relating perpetration sexual abuse children conducting critical interpretive synthesis eleven electronic databases searched period april may included socindex social services abstracts applied social sciences index abstracts family society studies worldwide project muse psychinfo family society plus jstor expanded academic asap web science google scholar key individual journals also searched including child abuse neglect journal interpersonal violence well grey literature search guided research question could prevention agenda relating sexual abuse perpetrated children enhanced systematic literature search yielded titles papers included final synthesis authors identified five domains operating evidence base characteristics causes communications interventions treatments synthesising construct emerged review prevention enhancing interactions construct referred potential enhancing prevention agenda exists evidence domains interact one another public health model prevention authors consider review timely contribution current agenda pertaining sexual abuse perpetrated children provides researchers policy makers practitioners field evidence informed conceptualisation opportunities enhancing prevention work
growing recognition urban trees provide various valuable benefits services enhanced human wellbeing however also cost terms public health either directly allergies harboring species representing health risk humans paper focuses forest insect species pine processionary moth thaumetopoea pityocampa caterpillars develop gregariously winter conspicuous silk nest coniferous hosts disturbed larvae release urticating hairs cause human animal serious health problems purpose survey inventory individual trees belonging potential host species estimate density pityocampa assess spatial pattern insect population city scale conducted exhaustive inventory potential coniferous host trees five municipalities north orleans france tree identified geo referenced number moth nests hosted counted total urban trees representing coniferous taxonomic units investigated distribution pityocampa exhibited marked spatial structure citywide geostatistics allowed draw risk maps revealing strong patchiness provide first estimate pityocampa host tree preference urban context found pinus nigra pinaster sylvestris attacked trees also report numerous cases pityocampa occurrence exotic ornamental himalayan cedar cedrus deodara management implications findings two fold risk maps constitute useful framework communication public information help developing control strategies species frequently used ornamental purposes poor quality hosts regarding pityocampa therefore preferred public place usually frequented vulnerable people schools nurseries hospitals published elsevier gmbh
lack evidence broad health care costs treating spine trauma patients without neurological deficits conservatively aim present study estimate primary secondary health care sector costs associated conservative treatment spine fractures well determinants patients identified hospital administrative system based relevant diagnostic codes inclusion criteria spine fractures age conservative treatment exclusion criteria neurological involvement fractures secondary osteoporosis malignancy health care utilization costs retrieved national administrative databases covering entire health care sector cervical thoracic lumbar fracture patients included study total health cost estimated notsign notsign notsign cervical thoracic lumbar regions respectively hospital admissions accounted vast majority costs primary health care accounted less prescription medication less determinants costs included fracture site concomitant lower limb injuries spinal fractures even mild ones appear incur substantial health care utilization costs health care costs conjunction cervical fractures two fold affiliated thoracic lumbar fractures among concomitant injuries lower limb injuries exert substantial influence health care costs
rapid growing interest using biomass alternative source clean sustainable energy production work hybrid system developed combine anaerobic digestion gasification energy recovery yard waste woody biomass feasibility proposed hybrid system validated experimentally numerically energy efficiency maximized varying energy input drying process experiments performed two stages first stage yard waste conducted mixing anaerobic sludge second stage gasification added post treatment residue syngas production gasification experiments residue woody biomass conducted varying mixing ratios varying moisture contents residue optimal energy efficiency found mixing ratio residue moisture content two kinetic models adapted prediction biogas produced process syngas produced gasification process respectively experimental numerical results showed full utilization biomass could realized produce energy combination two technologies elsevier ltd rights reserved
wealth research parent child communication sexual reproductive health rights srhr influence young people sexual behaviours however global north aim study explore parent child communication three south african provinces eastern cape kwazulu natal kzn mpumalanga nine peer focus group discussions fgds conducted young adult black african men women spoken languages data analysed thematically findings revealed cultural religious constructions taboo silenced direct communication restricted discussed topics parents older age low educational level lack knowledge discomfort talking sexuality matters reported restrict conversations children sex sexuality influence factors differed parents residing urban setting liberal counterparts residing rural areas child age gender also reported consideration approaching conversations need interventions assist parents communicate children srhr topics beyond pregnancy hiv aids interventions take account address factors seem influence parent child communication
increasing diversity educational background students entering ordinary degree level honours degree level programmes engineering dublin institute technology dit partly result student reasoning basic electricity concepts often differs accepted explanations paper reports analyses reflects results multiple choice diagnostic test assess student understanding concepts developed high school college students taken pre test four cohorts first year students dit level engineering programme two cohorts first year students dit level engineering programme performance student cohorts similar little influenced previous exposure relevant subjects second level high school education academic year updated version diagnostic test taken pilot study one cohort first year students dit level engineering programme test administered pre test instruction post test immediately instruction delayed post test approximately fifteen weeks instruction results show little improvement conceptual understanding resistive electric circuits measured test pre test post test delayed post test scores compared
increasing interest field parallel distributed data mining grid environment past decade important branch spatial data mining spatial outlier mining used find interesting unexpected spatial patterns many applications paper new parallel distributed spatial outlier mining algorithm som proposed simultaneously detect global local outliers grid environment som delaunay triangulation tin based approach encapsulated deployed distributed platform provide parallel distributed spatial outlier mining service subsequently distributed system framework som designed top geographical knowledge service grid geoksgrid developed research group two step strategy spatial outlier detection put forward support encapsulation distributed deployment geographical knowledge service two key techniques geographical knowledge service parallel distributed computing delaunay triangulation implementation som algorithm discussed finally efficiency spatial outlier mining service analyzed theory practicality confirmed demonstrative application abnormality analyzing soil geochemical investigation samples fujian eastern coastal zone area china effectiveness superiority som balanced scalable grid environment verified comparison popular spatial outlier mining algorithm slom involvement large amount computing cores
collection methods finding explicit travelling wave solutions nonlinear partial differential equations nlpdes literature quite large amount methods employ balancing principle methodology work positive integer values yet well established formula balancing specific rule determine adequate balancing principle works number positive negative rational study propose new balancing principle works large range numbers either positive negative rational makes possible obtain new original explicit travelling wave solutions nonlinear partial differential equations nlpdes elsevier ltd rights reserved
increasing interest describing different variants subtypes characterize heterogeneity behavior problems aim supporting early detection prevention well facilitating research etiological differences work examines course occurrence callous unemotional traits anxiety anx oppositionality odd levels longitudinal community sample sample year old preschoolers followed age assessed annually dimensional measures callous unemotional traits oppositional defiant disorder anxiety related psychological constructs answered parents teachers performed children growth mixture modeling yielded six trajectories null anxincreasing anx odd odd decreasing odd increasing anx decreasing represent variants previously described older subjects specifier odd limited prosocial emotion odd decreasing increasing showed deficits executive functioning attention aggressive behavior social cognition comparison null trajectory secondary variant showed severe clinical picture presented difficulties executive functioning worse environmental characteristics worse outcomes age possible identify heterogeneity disruptive behavior problems preschool age identification homogeneous groups category disorders may help design suitable treatments specific components specific difficulties progress etiological research class elsevier ltd rights reserved
mounting evidence across taxa females breeding competitive environments tend allocate testosterone offspring prenatally offspring typically aggressive faster growing phenotypes date study determined mechanisms mediating maternal effect influence offspring phenotype however levels estrogen receptor alpha gene expression linked differences early growth aggression thus maternal hormones may alter gene regulation perhaps via dna methylation offspring prenatal development performed pilot study examine natural variation testosterone allocation offspring egg yolks wild eastern bluebirds sialia sialis varying breeding densities percent dna methylation dinucleotides promoter offspring brain regions associated growth behavior hypothesized breeding density would positively correlated yolk testosterone prenatal exposure maternal derived yolk testosterone would associated greater offspring growth decreased promoter methylation yolk testosterone concentration positively correlated breeding density nestling growth rate percent dna methylation one five investigated cpg sites site diencephalon promoter none telencephalon percent dna methylation diencephalon cpg site positively correlated growth rate data suggest possible role epigenetics mediating effects maternal environment offspring phenotype experimentally examining mechanism larger sample size future studies may help elucidate prominent way animals respond environment determining mechanisms mediate maternal effects begin understand potential heritability mechanisms impact maternal effects capable producing evolutionary scale
scientific evidence suggest correlation hypoxia physiology micturition himalayan scientific mountaineering expedition performed tests investigate functional interactions altitude hypoxia uroflowmetry parameters women tests carried seven women normoxic meters sea level hypoxic conditions return descent following measures determined uroflowmetry parameters saturation peripheral oxygen expected decreased increasing altitude micturition flow time flow volume voiding time increased altitude indicating negative correlation conclusion young adult women micturition physiological parameters affected adaptation hypoxia correlation strongly suggests role hypoxia changes data could help support design new strategies prevention medical treatment example latter might hyperbaric oxygen therapy studies proved able reduce symptoms patients hypoxic bladder
disagreement literature regarding presence elevated testosterone concentrations boys autism spectrum disorder asd explore disagreement presence significant differences testosterone concentrations young males autism spectrum disorder asd normally developing controls aged investigated total young males asd age matched non asd males contributed samples saliva set time assayed testosterone concentrations significant difference testosterone concentrations two entire samples examined two yearly intervals asd participants significantly lower testosterone concentrations age also exhibited relatively homogeneous testosterone concentrations compared non asd participants data challenge extreme male brain hypothesis asd suggest asd young males delayed pubertal development developmental variability expected wider population present
substantial literature impact mass media children adolescents health development question role new technology plays media influence subject review discussion particularly regarding health risks intervention article takes brief look online usage theoretical mechanisms might make internet access problematic terms risks compared traditional media television film one risks known today cyberbullying internet harassment scrutinized detail
thermal imaging become readily usable tool crop agricultural water management since allows quick determination canopy surface temperature linked transpiration give idea crop water status last years resolution thermal imaging systems increased weight decreased fostering implementation unmanned aerial vehicles uav civil agricultural engineering purposes approach would overcome limitations site thermal imaging allowing mapping plant water status either field farm scale taking thus account naturally existing artificially induced variability scales aim work evaluate extent high resolution thermal imaging allows evaluating instantaneous seasonal variability water status within vineyard novelty significance approach specifically designed build unmanned aerial vehicle uav provided high resolution imaging pixel used commercially relevant acreage set used obtain crop water stress index cwsi thermal images clear sky day cwsi values compared stem water potential psi stomatal conductance measured sampling sites across vineyard moment images acquired order evaluate potential cwsi acquired single day estimate within vineyard patterns variation water status spatial modeling approach used cwsi correlated well moment image acquisition showing great potential monitor instantaneous variations water status within vineyard information provided thermal images proved relevant seasonal scale well although match seasonal trends water status mimicked physiological processes occurring ripening therefore picture variations water status required would necessary acquire thermal images several dates along summer elsevier rights reserved
thermal management satellite equipment one significant issues space industries heat generated electrical component dissipated avoid damaging satellite heat pipe discrete heat sources often used remove heat flux satellite heat dissipating equipment work two dimensional analysis used evaluate thermal performance cylindrical heat pipe multiple heat sources evaporators using nanofluid pure water alo water mixture used working fluids effect particle concentration level distilled water head load wall temperature pressure drop velocity field thermal resistance thermal hydraulic performance heat pipe size investigated remarkable decrease wall temperature observed especially heat sources found heat transfer coefficient increases particle concentration increases existence optimal particle concentration level lowest pressure drop thus best thermal hydraulic performance established significant reduction thermal resistance size heat pipe nanofluid used results also show applying nanofluid higher heat loads heat removal required pronounced effect heat transfer rate augmentation temperature reduction satellite equipment useful feature alo water proved potential smart material satellite equipment cooling application elsevier masson sas rights reserved
thermal modeling used thermal investigation optimization sensors instruments structures results depend chosen modeling approach complexity model quality material data information heat transport conditions object investigation despite widespread application advantages limits modeling approaches partially unknown comparison different modeling approaches simplified analytically describable demonstration object used object steel rod well defined heat exchange conditions environment analytically describable models equivalent electrical circuits simple complex finite element analysis models presented using different approaches static dynamic simulations performed temperatures temperature fields rod estimated results calculations comparisons measurements identification sensitive points approaches shown general conclusions thermal modeling complex equipment drawn
thermochemical energy storage tces systems utilize reversible reactions store solar energy chemical form present work focuses cobalt cobaltous oxide coo coo pair based redox cycle active oxide coated cordierite honeycomb structure redox cycle cobalt oxide uptakes releases oxygen air stream coming direct contact thus air acts reaction medium well heat transfer fluid htf configuration storage material works heat storage medium also heat exchanger two dimensional axisymmetric numerical model simulate heat mass transfer chemical reaction thermochemical heat storage reactor developed experimental results capacity prototype reactor installed solar tower julich test facility germany used validate numerical model time dependent boundary conditions form inlet temperature inlet mass flow rate experiments employed numerical model temperatures redox material different locations inside prototype thermochemical storage heat exchanger reactor used numerical model validation total energy stored released sensible well chemical experiments also compared numerical model results study concluded numerical model accurately predict charging discharging processes cobalt oxide based thermochemical storage reactor system multiple redox looping cycles model allows better understanding complete process helps identify effect variation boundary conditions system elsevier ltd rights reserved
thermodynamics dependent microstructure phase physical model predictions material characteristics demonstrated aluminum alloys application sente software java materials program jmatpro mesoscale computation materials engineering software jmatpro reveals phase constitutions function input composition temperature time using material property databases physical models calculates temperature dependent physical mechanical properties secondary application elastic bulk moduli constituent phases inclusions derived gibbs energy jmatpro used predict maximum levels microscale shear stresses hydrostatic pressure comparison conditions known cause incipient spall alloy levels microscale shear stress around inclusions shown equal exceed level von mises calculated shear yield strength
thermoplastics subjected static mechanical loads tend creep deform respect time motivated creep experiments finite strain material model proposed approach models recoverable irrecoverable deformations viscoelastic viscoplastic contributions respectively viscoelasticity based generalized maxwell model viscoplastic component quadratic pressure dependent flow potential typical creep viscosity function isotropic damage forinulation models degradation material properties respect time however newly proposed recovery variable hinders damage evolution especially long term processes reduced predictor corrector scheme presented efficient solution implicit numerical integration model context finite element calculations creep experiments constant load cyclic loading unloading shown characterize mechanical long term behavior polyoxymethylene semicrystalline thermoplastic finite element calculations experiments proposed material model demonstrate capability model long term deformation behavior polyoxymethylene elsevier ltd rights reserved
days design construction industry challenged question architects engineers contractors building owners using information technology automate practices building operation benchmarking following case study interviews critically evaluate integrated project delivery process thyssenkrupp quarter essen germany built decommissioned energy concept thyssenkrupp headquarters primary energy consumption measured kwh ecological footprint less emissions similar buildings category one major innovative systems solar facade controlled system total green building automation desigo siemens specifically developed building automation system bas called green building monitor supervise building consumption data continuously expert analysis desigo includes specially developed energy efficient operating control concept rooms
abstract presentation shall address issues arising scarcity water supply due climate change increasing demand urban population limited water resource inaccessibility deliver water supply rural communities papua new guinea rainwater harvesting system considered paper shows application axiomatic design designing prototype rainwater harvester visual presentation infrastructure use helps build model without compromising feature geographical set place gravity driven considering rainfall scenario location demand health considerations authors published
application note introduces arduino based led system useful cultivation various microalgae species well plants system based rgb apac leds connected external arduino microcontroller allowing flexibility via programming modification upgrades describe detail functions produce white light mixed colors led strips well ability generate intermittent flashing pulsing light capabilities system offer unique applications industry research aim provide low cost open source tool order improve promote cultivation photoautotroph species bacteria microalgae plants using leds elsevier rights reserved
article addresses classical fluid mechanics problem effect capillary action column viscous liquid analyzed quantifying time dependent penetrated length narrow channel despite several past studies rigorous mathematical formulation inherently unsteady process still unavailable existing works resort crucial assumption valid mildly transient systems approximate theories use integral approach penetration described equating total force acting domain rate change total momentum however viscous resistance temporally varying condition assumed resistance created quasi steady velocity profile thus leading order error appears due approximation true variation time strong enough causing negligible transient deviation hydrodynamic quantities present paper proposes new way solve problem considering unsteady field unknown variable accordingly analysis applies eigenfunction expansion flow unknown time dependent amplitudes along unsteady intrusion length calculated system ordinary differential equations comparative exploration identifies situation integral approach rigorous technique based eigenfunction expansion deviate also reveals two methods differ substantially short time dynamics initial stage asymptotic perturbation shows two sets results coincide long time behavior way findings provide comprehensive understanding physics behind transport phenomenon
article addresses concerns growth global governance may bringing decline significance democratic sources political legitimacy one approach evaluating concerns ask whether respective patterns legitimation private public authority differ whether refer similar set normative standards private transnational governance regimes provide useful contexts assess presumed democratic erosion seem almost make case decline regulatory authority exercised non state actors nature lack kind authorization afforded democratic procedures legitimize state based regulation addition intrinsically linked notion politics form problem solving rather exercise power given characteristics governance arrangements kind subjected criticism one would expect justificatory responses relate primarily performance normative criteria fundamental individual rights imperative democratic procedure playing minor role basis qualitative content analysis study tests three ideal type patterns legitimation plausibility case selected examination recent controversy surrounding hybrid governance regime operates prevent use performance enhancing drugs sport debate offers possibility nutshell comparison respective patterns legitimation used criticizing justifying state non state regulatory authority comparison yields two findings first values used appraise state based components sporting world hybrid regulatory regime differ systematically used appraise private elements contestation justification cases founded normative criteria relating fundamental individual rights democratic procedure performance related considerations second finding justificatory grounds first type appear diminishing importance vis second
article analyses perceived group discrimination first second generation immigrant respondents different countries origin currently living one countries addition testing effects individual factors article estimates effects macro characteristics origin destination countries community variables migration history groups relevant perceived discrimination immigrants citizenship speak majority language home least one native parent perceive less group discrimination whereas religious respondents especially religions differ comparison majority perceive group discrimination furthermore macrocharacteristics country origin important explaining differences european countries immigrants socio economically developed countries higher living standards reason comparable native population less likely perceive group discrimination
article analyses public responses china shanghai performance programme international student assessment pisa based data obtained media accounts materials published research findings show responses china generally reflective measured self critical drawing upon gadamer notions tradition horizon prejudice paper contends responses reflect prevailing worldviews china perceive shanghai education system academically rigorous exam oriented burdensome argued confucian knowledge traditions structures china shape chinese interpretations pisa assessment format leading downplay shanghai success study introduces metaphor triadic eyes highlights mediating effects local eyes policy actors era global educational governance
article analyzes dynamic changes mobile phone popularity based phone features time period selected study interesting many technical innovations took place molding mobile phone market dramatically study utilizes comprehensive phone model sales data collected finland combined temporally ordered probabilistic models discover time behavior predictivity precisely tree augmented bayes classification method adapted detect phone characteristics best predict annual phone popularity measured phone model unit sales linear regression chow test used discover potential trends structural breaks strength predictivity measured kullback leibler divergence kind systematic longitudinal analysis highlights patterns otherwise possible observe study discovered operating system clearly feature increasing strength predicting popularity time contrast sixteen features structural breaks breaks related technical evolution phones display communication camera capabilities notably structural break related phone manufacturer brand interpreted market turning hardware software driven mode contributed nokia failure symbian windows operating systems google success hardware independent operating system android elsevier ltd rights reserved
article argues study literary representations landscapes aided enriched application digital geographic technologies example article focuses methods preliminary findings litescape atlas literary landscapes mainland portugal going project aims study literary representations mainland portugal explore connections social environmental realities past present litescape integrates traditional reading practices distant reading approaches along collaborative work relational databases geographic information systems gis order classify analyse excerpts works portuguese literature according set ecological socioeconomic temporal cultural themes argue herein combination qualitative quantitative methods response difficulty obtaining external funding lead increased productivity pursuit new research goals creation new knowledge natural cultural history proof concept article presents two initial outcomes litescape project case study documenting evolving literary geography lisbon case study exploring representation wolves portuguese literature
article compares characteristics health care utilization patterns homeless veterans entering substance use disorder sud treatment baseline self report medical record data collected homeless veterans participating randomized trial sud housing case management veterans categorized newly episodically chronically homeless compared clinical characteristics health care utilization year prior baseline groups differences seen stimulant use bipolar depressive disorders significant majority accessed emergency department services nearly half accessed inpatient services utilization among chronically versus newly homeless majority groups attended primary care mental health visits newly episodically chronically homeless veterans initiated multiple sud treatment episodes significant proportion veterans struggling homelessness suds appear remain unstable despite high utilization acute preventative services
article considers speed control asymmetrical dual three phase generator using inner loop model based predictive control mbpc predict effects future control actions state variables order achieve goal algorithm uses luenberger observer kalman filter purpose estimating rotor currents thereafter speed control used reach maximum power point tracking mppt ensures delivered load finally comparison efficiency mbpc considering rotor current estimators used estimator based state space representation
article deals large problem interferometric synthetic aperture analysis begins study transverse distance influence orientation interferometric baseline processing elevation problem solving relative horizontal resolution conventional synthetic aperture radar carried including ambiguity choose optimum parameters interferometer thus improve surface topography found indeed take picture earth surface angle inclination baseline alpha best results obtained copyright john wiley sons ltd
article describes health hearts united longitudinal church based intervention reduce cardiovascular disease cvd risk mid life older african americans using community based participatory research cbpr approaches undergirded socio ecological theory transtheoretical model behavior change month intervention developed six north florida churches randomly assigned treatment comparison intervention framed around three conceptual components awareness building individual knowledge development clinical learning individual small group educational sessions efficacy development recognition sustainability identified three lessons learned providing consistency programming even participant absences providing structured activities assist health ministries sustainability addressing changes church level recommendations include church based approaches reflect multi level cbpr collaborative faith model
article describes people sensations daylight practical daily engagements sun daylight based qualitative research project denmark article shows danes experience world sun daylight illustrates significance bodies lives describe taking biomimetic approach present metaphor like plants people crave daylight order feel well showing people engagement sun daylight phenomenon natural light becomes imbued sociality show people design daily life accordance sun sensation daylight normally taken granted acknowledged physiological element world foregrounded shown sense people may physiological origin daylight hits eye whose impact people lives may best investigated psychologically socially studying daylight sensation practiced people entangles intertwines everyday lives
article describes development validation new thermomechanically coupled multi layered shape memory alloy beam finite element finite element formulated assuming coupled equilibrium equations mechanical thermal problems constitutive shape memory alloy model lagoudas coworkers implemented formulation multi field kinematic hypotheses proposed combining first order shear displacement field sixth order polynomial temperature field thickness beam enabling adequate representation temperature phase transformation profiles due rapid thermal loading uneven thermal loading boundary conditions multi layered configurations variable thermal properties non linear transient discretized equations motion shape memory alloy beam synthesized solved using newton raphson method implicit time integration scheme numerical results illustrate time response uniform layered niti beams various thermomechanical loads predicted developed finite element correlations beam element predictions plane stress two dimensional finite element shape memory alloy models demonstrate excellent agreement calculated displacement temperature phase transformation fields additionally developed beam finite element yields computationally fast simulations providing effective tool design simulation rod beam strip shape memory alloy actuators active structures
article discusses ethical methodological aspects related ethnographic research conducted drugstore city rio janeiro brazil aim analyzing dynamics emergency contraception commercialization drugstore well social interaction seller pharmacist customer time latter purchases pill investigation permeated challenges related commercial nature drugstores country even though commercial establishments legally considered health related interest first introduce discussion background fieldwork quest research approval research ethics committee concerned drugstore owners process getting field discussed perspective relations positions taken female researcher subjects analysis choice ethnography private context drugstores aiming identify commercialization emergency contraception crucial apprehend complex processes related subtle games sexuality reproduction control space interaction female researcher research subjects fieldwork constitutes socially constructed process according specific circumstances delimit collection data research thus research method ethical attitude must properly defined clear researcher interconnected depending creative exercise critical evaluation researcher relations within field
article empirically examines postulated effects least single terrorist attack measure monthly international arrivals study uses tsoutliers package detect outliers time series data following terrorist attacks five destinations contribution paper found methodological approach implemented consistently across five destinations findings suggest evidence support view consistent disturbance well fitted time series data fingerprint created terrorist attack across five different destinations even least one case destination different times copyright john wiley sons ltd
article examined levels stress associated coping strategies among academics adopting positive psychology approach influence character strengths hope optimism gratitude self efficacy stress subjective well swb mental health examined academics university study explored relationship coping styles work coping variables sense coherence work locus control stress significant differences stress well mental health measures found participants gender whether full time part time employment level seniority within university participants using problem focused coping experienced lower levels stress dysfunctional coping positive predictor stress hope agency hope pathway gratitude optimism self efficacy strongest positive predictors satisfaction life swl levels perceived stress negatively predicted swl gratitude hope agency self efficacy positively predicted positive affect stress negative predictor gratitude hope agency self efficacy optimism negative significant predictors negative affect stress positive predictor gratitude positively predicted mental health stress negative predictor optimism significant moderator relationship stress mental health academics higher levels gratitude self efficacy hope optimism report lower levels stress work higher levels well measured higher life satisfaction higher positive affect lower negative affect new approaches stress management training suggested based findings
article examines survey interview responses british asian youths primarily muslims consider group perceptions forced marriage along preconceptions around ways exercise right marry findings suggest learned discriminatory values norms regarding gender roles remain integral marriage perceived perpetrated experienced whereas women tend compliant regarding parents family wishes men often motivated sense pride masculinity initiatives intended understand support recovery victims prevent practice would benefit incorporating consciously gendered understanding actively challenge socially constructed gender roles affected communities
article examines british national party bnp opposition gay men drawing sociological concept homohysteria examines written material bnp publications decades looking specifically aids crisis party belief queer conspiracy role homosexuality played decline national front birth bnp first study dedicated british fascism anti gay prejudice article argues existing scholarship fails understand degree nature anti gay sentiment bnp concluding party homohysteric inception
article explores analyzes significance green building design states new concept green building design order establish concept realize sustainable development green building article introduces concept characteristics green building states meaning green building development many aspects puts forward strategy develop green building economy green building materials modern civilization brings people convenience comfort meanwhile also gradually realize isolation brought buildings human nature damage influence environment order let buildings back nature close nature realize coexistence buildings nature experts scholars put forward concept green building green buildings refer buildings provide people comfortable healthy safe living space make use resources high efficiency life cycle buildings minimally influence environment also called ecological building sustainable building
article explores impact losing child especially losing children including losing child mental health happiness loneliness parents chinese government implemented strict restrictions number births family since resulting creation millions child families using baseline data china health retirement longitudinal study find bereavement child associated lower levels mental health happiness higher levels loneliness parents even adjust demographic socioeconomic characteristics effects significantly stronger losing children results strong implications population control elderly care mental care policies especially china developing countries social security system yet sound
article explores link nationalism expressed burman state ethnic student opposition movements emergence multiethnic women movement engaged resistance activities focusing women involvement oppositional nation making projects article aims broaden understanding gender conflict highlighting women agency war drawing interviews carried founding members women movement non state armed groups others active civil society article investigates gendered political consciousness arose dissatisfaction women secondary position armed opposition groups leading women forming movement opposition conflict per opposition rejection militarism process redefining notions political involvement agency invoking solidarity based gendered positioning rather ethnic identity women movement resisted dominant nation making projects created nationalism inclusive multiethnic differences burmese women multiple wartime roles thus serve upset supposed dichotomies militancy peace victim combatant process redefining relationship gender nationalism militancy
article focuses testing path oriented querying approach hierarchical data relational databases authors execute user study compare path oriented approach traditional sql two perspectives correctness queries time spent querying also analyze kinds errors typical path oriented sql path oriented query languages popular context object orientation xml however relational databases common paradigm storing data sql common manipulating data querying hierarchical data sql user must specify join conditions explicitly hierarchy levels path oriented sql new alternative expressing hierarchical queries relational databases authors study users spent significantly less time writing path oriented sql queries made fewer errors query formulation
article probed innovative conversion micromouse competition systematic curriculum design integrates practice theory micromouse competition event small robot mice designed solve maze process includes multi disciplinary knowledge electrical computer engineering mechanical engineering algorithm design limited competition rules micromouse easy learn difficult master provides high suitability teaching processes foundation courses embedded system undergraduate students paper elaborates emphasis difficulties innovation conversion process core student engagement class students must take part whole micromouse design progress comprehend interactive method hardware software embedded devices strengthen ability applying professional skills students required participate entire micromouse building process including welding assembling environment building debugging finishing competition groups curriculum focuses training students research interests competition skills teamwork spirit final examination scores mainly based group ranking final round technology innovators given appropriate incentives
article integrates knowledge health psychology life course development social psychology outline theoretical framework identifying investigating promoting evaluating beneficial action beneficial action defined subset prosocial motivated benefit others may include self interest altruistic prosocial motivation without self interest behavior uses consequential scientific knowledge increase freedom within global population beneficial action theory seeks increase political social actions planned evaluated ensure key tasks human development central among broadening social identity ensure human potential use science modify natural environment achieves benefits global population article presents theoretical framework conceptualizing psychological processes underlie development application evaluation beneficial action individuals populations need conceptualize beneficial action arises related observations first certainty knowledge beneficial outcome specific human action increases moral motivation engage action example consensus among psychologists professions unethical engage therapeutic practices evidence neutral harmful consequences second due rapid increase scientific knowledge range human action scientifically ascertainable consequences rapidly expanding third advancing scientific knowledge means human actions increasingly powerful consequences humanity natural world warranting careful consideration ensure global population benefits
article introduces thematic issue consisting five articles analyze complex interrelations gender norms representations construction nationalism post soviet republics central asia drawing gender feminist studies first section explores central asian nationalisms promoted hierarchized gender roles reinforce legitimacy noticeably invoking authority tradition second section examines soviet period continues shape contemporary nation building processes region also latter creating new historical references emancipate soviet legacy soviet policy toward women particular third section examines gender norms promoted central asian states may affect women everyday life may negotiate refuse promote norms final section show gender equality become watchword international organizations agendas analyze production implementation international agenda setting specific national context
article investigates varieties knowledge flooding contribute effective flood management governance configuration chennai india drawing assemblage perspective using configurations approach socio spatial analyses city trace knowledge construction processes around two networked infrastructures drawing different discourses actor coalitions processes practice see technical knowledge storm water drains embedded transformed within primary government network complementary knowledges ery system expressed counter mappings academic activists identifying potential intersections knowledge processes indicates strong potential link long term water management strategies would mutually contribute addressing city issues flood risks drinking water scarcity however find varieties knowledge around chennai run parallel networks intersections presenting distinct institutional boundaries cross boundary knowledge sharing lastly using integrated heuristic framework analyse contributions different streams knowledge remaining gaps order assess potential building interconnections chennai configuration elsevier ltd rights reserved
article investigates sampled data disturbance rejection control problem class non integral chain systems mismatched uncertainties aiming reject adverse effects caused general mismatched uncertainties via digital control strategy new generalized discrete time extended state observer first proposed estimate lumped disturbances sampling point disturbance rejection control law constructed sampled data form lead easier implementation practices carefully selecting control gains sampling period sufficiently small restrain state growth zero order holder input bounded input bounded output stability hybrid closed loop system disturbance rejection ability delicately proved even controller dormant within two neighbor sampling points numerical simulation results demonstrate feasibility efficacy proposed method
article surviving life help comic books abusive mother middle rural denmark
article assessment several tools mer counting purpose create reference framework bioinformatics researchers identify computational requirements parallelizing advantages disadvantages bottlenecks algorithms proposed tools mer counters evaluated article bfcounter dsk jellyfish kanalyze khmer kmc mspkmercounter tallymer turtle measured parameters following ram occupied space processing time parallelization read write disk access dataset consisting reads used corresponding human chromosome assessment performed two mer lengths obtained results following pure bloom filter based tools disk partitioning techniques showed lesser ram use tools took less execution time ones used disk partitioning techniques techniques made major parallelization ones used disk partitioning hash tables lock free approach multiple hash tables
article based qualitative study diet education among student preschool teachers problem discussion student preschool teacher learn education food meals nutrition material used article comprises interviews student preschool teachers one university one college norway preschool teacher education three years university college study bachelor degree survey results show student preschool teachers receive even element training comes food meals including nutrients vitamins minerals although education must prepare job outside kindergarten practical cooking almost completely absent education including hygiene student preschool teachers know fat use cooking food senses allergies food culture discussed education little correlation formal curricula connection food meals training preschool teacher students received education
article offers brief selective review important trends issues nonverbal research last years although volume range research increased dramatically period adequate integration extensive body work lacking response concern article proposes nonverbal communication might framed terms adaptive efficient system managing social worlds several basic characteristics system outlined utility organizing facilitating research discussed
article offers critique concept hyper masculinity nuanced place contingent critical way think masculinity use concept hyper masculinity highlight conceptual problem essentialist essentialized notions gender constructionist notions masculinity gender escape essentialist problem however critiquing offering placed conceptualization hyper masculinity based seattle gay leather community push boundaries masculinity gender arrive nuanced embodied place based contingent understanding hyper masculinity thereby side stepping debates essentialist constructionist participant observations ethnographic interviews men practice hyper masculinity within gay leather community seattle usa interrogate hyper masculinity within community demonstrate reinforces subverts heterosexual gender roles homonormativity resumeneste articulo ofrece una critica del concepto hiper masculinidad una forma critica mas matizada contingente con lugar pensar masculinidad utilizo concepto hiper masculinidad para resaltar problema conceptual entre las nociones esencialistas las desencializadas genero los conceptos construccionistas masculinidad genero escapan problema esencialista sin embargo criticar ofrecer una conceptualizacion localizada hiper masculinidad basada comunidad gay cultura leather cuero seattle amplio los limites masculinidad genero para arribar una comprension mas matizada corporizada basada lugar contingente hiper masculinidad eludiendo esta forma los debates esencialistas construccionistas traves observacion participante entrevistas etnograficas con hombres que practican hiper masculinidad dentro comunidad gay cultura leather seattle interrogo hiper masculinidad dentro comunidad para demostrar como refuerza subvierte los roles genero heterosexuales homonormatividad
article presents critical review extant literature media violence effects violent criminal behavior problems within media violence literature limit causal conclusion appropriate body literature discussed argued contrary common belief current literature provide ample support conclusion media violence causes aggressive violent behavior article offers positive suggestions future media violence studies suggestions role forensic psychologists communicating media violence research information courts public also provided
article presents novel mixed thermoelastohydrodynamic tehd model lateral lubricating interfaces exist floating lateral bushings gears external gear machines egms proposed model integrates influence surface asperities along fluid structure thermal interaction interface especially regions low film thicknesses following stochastic approach modelling mixed lubrication regime furthermore current work includes validation predictions mixed tehd model experimentally measured leakages lateral gap compares performance model previously developed full film tehd model lateral gaps egms
article presents profile intimate partner homicides iph committed within london incorporating gendered comparison perpetrators relationships data sourced original police files offenses committed capital male female perpetrators common international descriptive studies results indicate comparative differences partners according perpetrator gender terms age profiles employment status experience mental health issues intoxication time killing possession criminal convictions gender based iph descriptive studies tended focus collation either victim perpetrator relationship characteristics often isolation one another assessments parties interact within fatal relationships invariably absent yet relationship forms backdrop fatal acts perpetrated study therefore provides insight profile iph committed within london none previously existed also demonstrates advantages incorporating relationship concordance measures inclusion measures researching iph assists homicide investigators understanding dynamics taking place within cohort fatal relationships police also provides researchers useful platform enhance understanding crucial aspect relationship defines iph distinguishes unique subset homicide
article presents study aimed assess accessibility use quality harvested rainwater three rural communities ghana government ghana local international development organisations sponsored domestic rainwater harvesting results showed rainwater storage facilities within recommended distance house amount rainwater per person per day recommended amount majority respondents therefore depended sources water though physico chemical quality rainwater met guideline limit drinking water bacteriological quality majority common water associated infections experienced prior project experienced project cet article presente une etude dont objectif etait evaluer accessibilite utilisation qualite eau pluie collectee dans trois communautes rurales ghana sein desquelles gouvernement pays des organisations developpement locales internationales ont finance collecte eau pluie niveau domestique les resultats ont montre que les installations entreposage eau pluie respectaient distance recommandee chaque maison quantite eau pluie personne jour etait inferieure quantite recommandee majorite des personnes interrogees dependaient donc autres sources eau qualite physico chimique eau pluie etait conforme ligne directrice oms pour eau consommation etait pas ainsi qualite bacteriologique majorite des infections communes associees eau recensees avant projet ont pas ete apres dernier presente articulo presenta los resultados aportados por estudio orientado valorar disponibilidad uso calidad del agua lluvia recolectada tres comunidades rurales ghana las que gobierno del pais varias organizaciones locales internacionales patrocinaron recoleccion agua lluvia nivel domestico los hallazgos obtenidos dan cuenta que las instalaciones para recoleccion lluvia ubican distancia recomendada mas mil metros cada casa cantidad lluvia persona dia conseguida estuvo por debajo recomendado razon por cual mayoria los informantes dependia otras fuentes agua bien calidad fisicoquimica del agua lluvia cumplio con los parametros normativos establecidos por oms para agua potable ocurrio mismo con calidad bacteriologica mayoria las infecciones mas comunes asociadas con agua existentes antes que implementara proyecto presentaron despues inicio
article presents exhaustive study influence design parameters number phases pole stroke current density behavior linear switched reluctance motor linear switched reluctance motor performance assessed taking account set quality indices energy conversion loop quality factor propulsion force per unit primary steel volume per unit copper mass per unit air gap surface force ripple factor study carried means two dimensional finite element analysis finally results discussed consequence set linear switched reluctance motor configurations optimal performance according quality indices defined
article presents instructional framework collaborative learning called cif aimed analysis level bloom taxonomy well mobile collaborative tool called mocas supports cif mocas aimed domain scope identifiers programming learning topic present programming courses engineering studies specification development mocas explicitly driven pedagogical goals atomic actions declared cif simple items collaborative activities furthermore cif mocas evaluated actual educational context respect students performance motivation students using cif mocas obtained statistically significant higher grades students studying individual collaborative basis using mocas addition measured statistically significant measures indicating students instructed cif mocas motivated students instructed collaboratively using cif mocas addition cif andmocas evaluation results experiences reported exemplify several software engineering practices design educational system based knowledge target domain namely bloom taxonomy evaluation users satisfaction mainly students motivation
article presents construction test stand created vstu multifunctional stand serves determination main operational characteristics cars truck transmissions stand consists dynapack dynamometric stand electric motor frequency inverter tested axle dynapack stand used load device simulating road resistance wheels output links half axles electric motor frequency inverter serves engine driving transmission input shaft measure necessary data pack sensors specific software used stand allows researching torsional vibrations transmission efficiency loads elements etc results test performed stand researching truck driven axle presented authors published elsevier ltd
article presents case year old girl admitted hospital exhibiting symptoms weakness vomiting decreased levels vigilance girl suffered shock unknown origin required resuscitation months earlier time diagnosed hypothyroidism treated thyroid hormones first blood tests hospital indicated hyponatraemia low blood sugar compensatedmetabolic acidosis considerably high tsh normal peripheral hormones clinical findings brown skin discoloration low blood pressure weight stagnation tremendous weight loss occurred first hospitalisation months earlier context made tentative diagnosis cortisol deficiency addison disease link hypothyroidism also suspected paper demonstrate diagnostic procedures schmidt syndrome aps type therapeutic measures
article presents development low cost microcontroller based interface microbioreactor operation arduino mega board digital input outputs including pulse width modulation outputs chosen perform acquisition control microbioreactor microbioreactor volume made poly dimethylsiloxane poly methylmethacrylate polymers reactor built equipped sensors actuators control reactor temperature mixing speed article discusses circuit microcontroller based platform describes signal conditioning steps evaluates capacity proposed low cost microcontroller based interface terms control accuracy system responses demonstrated proposed microcontroller based platform able operate parallel microbioreactor operation satisfactory performances control accuracy deviation less set point values responses range seconds recorded
article presents investigations constant frequency asymmetric voltage cancellation control resonant converter fed domestic induction heating system conventional fixed frequency control techniques used high frequency converters lead non zero voltage switching operation reduced output power proposed control technique produces higher output power conventional fixed frequency control strategies control technique zero voltage switching operation maintained different duty cycle operation reduction switching losses complete analysis induction heating power supply system asymmetric voltage cancellation control discussed article simulation experimental study constant frequency asymmetric voltage cancellation cfavc controlled full bridge series resonant inverter performed time domain simulation results open closed loop system obtained using matlab simulation tool simulation results prove control voltage power wide range pid controller based closed loop control system achieves voltage regulation proposed system step change load hardware implementation system cfavc control done using embedded controller simulation experimental results validate performance cfavc control technique series resonant based induction cooking system
article proposes multiobjective optimization model design macroscopic water system mexican city solves simultaneously planning scheduling water storage distribution tasks model considers rainwater harvesting reclaimed water reusing alternative water sources maximizes revenues water sales minimizes simultaneously water consumption land use case study based city morelia mexico solved found use alternative water sources harvested rainwater along appropriate planning scheduling storage distribution tasks potential reduce pressure natural reservoirs significantly approach considers simultaneously economic environmental concerns thereby contributing implementation sustainable alternatives urban water distribution american institute chemical engineers aiche
article proposes new practical robust attitude state feedback controller low cost hexarotor micro aerial vehicle effects noise angular velocity measurements multiple uncertainties called equivalent disturbance consist external time varying wind disturbance nonlinear dynamics coupling parametric uncertainties proposed method designed two simple steps firstly nominal cascade controller designed reduce noise angular velocity measurements achieve good attitude tracking performance nominal conditions second order robust compensator integrated closed loop system reduce effects equivalent disturbance proposed control design linear time invariant controller easily implemented practical applications compared advanced attitude controllers proposed controller incurs lower computational costs easily implemented low cost embedded microcontroller system addition practical computational design procedure intuitive online tuning method proposed controller presented article order provide complete reference micro aerial vehicle developers simulation experimental results presented demonstrate robustness proposed controller operation outdoor environments show good steady state dynamic tracking performance closed loop system prove tracking errors ultimately bounded within desired limits
article proposes novel advanced differential evolution method combines differential evolution modified back propagation algorithm new proposed approach applied train adaptive enhanced neural model approximating inverse model industrial robot arm experimental results demonstrate proposed modeling procedure using new identification approach obtains better convergence precision traditional back propagation method lonely differential evolution approach furthermore inverse model industrial robot arm using adaptive enhanced neural model performs outstanding results
article proposes novel architecture perform modular multiplication residue number system rns using sum residues highly parallel architecture implemented using vhdl verified extensive simulations modelsim pipelined non pipelined versions design implemented asic fpga platforms allow broad comparison proposed architecture requires one iteration complete modular multiplication achieves less delay compared existing rns binary modular multipliers complexity proposed design also less existing state art rns based modular multipliers high scalability flexibility proposed architecture allows used wide range high speed applications
article provides narrative review relationships several behavioural addictions pathological gambling problematic internet use piu problematic online gaming compulsive sexual behaviour disorder compulsive buying exercise addiction psychiatric disorders associations behavioural addictions depressive anxiety disorders strong seem relatively non specific strong links substance use disorders may support notion people prone addictive behaviours regardless whether involve substances problematic activities associations seem relatively specific example piu online gaming attention deficit hyperactivity disorder compulsive buying one hand eating disorders hoarding hand exercise addiction eating disorders quality research varies studies suffer methodological limitations including cross sectional correlational design non representative study populations small sample sizes reliance self report assessment instruments diverse diagnostic criteria conceptual heterogeneity behavioural addictions due limitations generalisability findings questionable direction causality unknown relationships behavioural addictions psychiatric disorders regardless aetiological uncertainty relationships often call modified treatment approach prospective studies needed clarify longitudinal relationships behavioural addictions psychiatric disorders
article provides update advances developmental intervention science occurred field early intervention children developmental delays past decade perspective developmental science findings related multiple reciprocal pathways influence development children delays inform early intervention practice discussed followed review two prominent lines early intervention research promoting children development enhancing parent sensitive responsiveness improving children cognitive social outcomes inclusive preschool settings merging policy initiatives knowledge developmental processes discussed key accelerating progress development comprehensive early intervention systems
article reflects way path creation theorem influenced intervention designed overcome intractable challenge community university partnership limpopo province south africa intractable challenge related legacy abstain faithful condomise abc campaign mounted early reduce global impact hiv aids despite context hiv aids epidemic shifted significantly since abc slogan invented community partner focus hiv aids related work reported abc legacy continued source frustration work order begin process overcoming challenge partnership decided beyond conventional boundaries community based hiv aids discourses develop intervention influenced complexity guiding heuristic design path creation theorem placing special emphasis initial conditions contingency self reinforcing mechanisms lock ins findings reflection indicate concepts associated path creation added value design particularly perspective incorporating processes emergence contingent events article concludes suggesting path creation theorem flexible heuristic application may opened opportunities explore synergies managing complex systems conventional forms managing community based interventions relating hiv aids
article reports mete analysis studies examining predictive validity implicit association test iat explicit measures bias wide range criterion measures discrimination meta analysis estimates heterogeneity effects within across domains intergroup bias interracial interethnic criterion categories interpersonal behavior person perception policy preference microbehavior response time brain activity versions tat stereotype attitude iats strategies measuring explicit bias feeling thermometers multi item explicit measures modem racism scale hoc measures intergroup attitudes stereotypes criterion scoring methods computed majority minority difference scores relative majority minority ratings minority ratings majority ratings iats poor predictors every criterion category brain activity iats performed better simple explicit measures results important implications construct validity iats competing theories prejudice attitude behavior relations measuring modeling prejudice discrimination
article reports second law based analysis vapor compression refrigeration cycle leads set explicit theoretical formulas coefficient performance cop analytical expressions provide fast accurate approach computer simulations vapor compression cycle without recourse thermodynamic diagrams equations state second law based analysis yields specific expressions entropy generations irreversible processes enabling evaluate thermodynamic features refrigerant elucidate thermodynamic mechanisms behind effects cycle processes including superheat subcooling throttling processes particular processes interact therefore paper presents global entropy generation analysis evaluating impact interacted processes cop elsevier ltd rights reserved
article reports elementary students understanding time context common classroom manipulatives notational systems students grades participated problem solving interviews involving different clocks quantitative results revealed students performances significantly different function tool available descriptive case studies grade students presented students demonstrated competencies conventions related benchmark numeric conversions hours minutes counting around clock yet partial competencies related integral relationship hours minutes implications theory treatment time curriculum instruction discussed
article reports development two courses designed students higher education game development programs period students three different arts design related strands program common taken advanced science classes part upper secondary education meant rather poorly equipped learn programming mathematics physics needed master order understand basics game development consequently courses designed way allowed students practically engage creating computer games alongside taught actual science needed order efficiently utilize skills working hypothesis project responsible teachers able run course way cohered principles problem based learning would create environment would enhance students motivation learn basic science well operative innovation skills needed fulfilling course requirements addition ideas developed within field situated experiential learning constituted theoretical points departure developing course article describes practical theoretical points departure developing courses reflects experiences made running summing authors conclude teaching needs line students worlds order educational experiences considered meaningful
article retraces history fertility theories illustrated founding texts grouped together single volume leridon les theories fecondite ined recent times reliable statistics available analysis fertility behaviours treated rather question philosophy morals political science religion birth social sciences nineteenth century first real theories fertility started emerge time demographic transition europe accompanying social economic transformations gave rise new demographic behaviours theoretical framework needed many new disciplines brought play including anthropology sociology economics political science psychology paradoxically demographers slow develop theoretical approaches doubtless discipline first made name quantitative science indeed overarching generally acknowledged theory fertility yet developed different approaches illustrated series pioneering texts present theories drawn wide range disciplines include analyses perspectives birth control gender
article reviews various hole transporting materials htms used perovskite solar cells pscs achieving high photo conversion efficiency pce operational stability pscs latest development solution processable solar cells offering pce similar par practically deployed silicon thin film solar cells htms electron transporting materials etms important constituents pscs selectively transport charges within device influence photovoltaic parameters determine device stability also influence cost article critically approaches role structure electrochemistry physical properties varied choice htms categorized diversely small long polymers organometallic inorganic photovoltaic parameters pscs conceived various device configurations achievements tailoring properties htms best fit pscs detailed well designed htm suppresses carrier recombination facilitating passage holes blocking electrons htm perovskite interface moreover many pscs htm acts first line defense external degrading factors humidity oxygen photon dose extent depends hydrophobicity permeability density
article studies phase transformation metastable beta alloy disclose morphological reason high strength high fracture toughness found ultrahigh strength ultimate tensile strength exceeds mpa owes mainly spheroidization alpha phase high fracture toughness exceeds mpa special lath shaped alpha particles compared needle shaped second alpha articles coarser lath shaped ones remove stress concentration lath tips consequently benefit improvement fracture toughness article also describes shape evolution alpha particles aging thermodynamically kinetically suggests optimized aging processing achieve ideal balance high strength high toughness alloy
article uses feminist poststructuralist approach explore contributors single thread discussion forum popular british parenting website mumsnet talk position good mothers qualitative analysis presented draws concept indexicality goffman frame analysis shows mumsnet users able negotiate discursive forces merge produce good mother subject position innovative ways able position good mothers way normative transformative legitimise subvert discourses work position way exploration leads suggest mumsnet talk forum seen space dominant discourses continue position individuals restricted gendered subjectivities also fruitful site negotiation resistance subversion cultural norms
brief comment explores significance number current lawsuits brought catholic church leaders ballarat victoria australia context enduring failures justice australian victims catholic clerical child sexual abuse examines obstacles criminal civil justice prevented church superiors held account child sexual abuse perpetrated catholic institutions explains responsibility australian governments courts catholic church justice survivors context
brief paper provides approximate online adaptive solution infinite horizon optimal tracking problem control affine continuous time nonlinear systems unknown drift dynamics relax persistence excitation condition model based reinforcement learning implemented using concurrent learning based system identifier simulate experience evaluating bellman error unexplored areas state space tracking desired trajectory convergence developed policy neighborhood optimal policy established via lyapunov based stability analysis simulation results demonstrate effectiveness developed technique
case features adult male moderate social anxiety disorder mild depressive symptoms showed initial positive response earlier experience cognitive behavior therapy relapsed started avoiding social situations continuing beliefs experiencing anxiety unacceptable treatment clinic focused shifting unhelpful thinking likelihood consequences becoming anxious reengaging avoided social situations could learn tolerate negative affect uncertainty treatment approach draws cognitive behavioral models social anxiety highlights advances clinical science especially recent work causal role interpretation biases tendency assign negative threatening meaning ambiguous situations maintenance reduction anxiety wiley periodicals inc
chapter deals numerical simulation exhaust engine passing pipe long diameter velocity temperature profiles along concentration exhaust gases plotted along axial length pipe coaxial surface junction thermocouple long diameter placed appropriate location pipe flow field reinvestigated cases lateral variation temperature velocity found negligible composition exhaust gas changes beyond axial length may possibly due chemical reaction exhaust gases ambient air one important objectives simulation estimate desired axial location thermocouple proposed experiment based simulated results found thermocouple mounted axial location inlet exhaust pipe
chapter describes polymers undergo temperature induced phase transition aqueous solution providing important basis smart materials different types temperature responsive polymers including shape memory materials liquid crystalline materials responsive polymer solutions briefly introduced subsequently chapter focus thermoresponsive polymer solutions first basic principles upper lower critical temperature polymer phase transitions discussed followed overview discussion important aspects various key types temperature responsive polymers finally selected potential applications thermoresponsive polymer solutions described
chapter discusses several methods forward looking explosive hazard detection ehd using infrared flir ground penetrating radar flgpr challenge detecting explosive hazards sensors multiple types targets buried different depths highly cluttered environment wide array target clutter signatures exist makes detection algorithm design difficult recent work application focused fusion methods including fusion multiple modalities sensors gpr fusion multiple frequency sub band images flgpr feature level fusion using multiple kernel ieco learning chapter demonstrate several types ehd techniques including kernel methods support vector machines svms multiple kernel learning mkl feature learning methods including deep learners ieco learning demonstrate performance several algorithms using flgpr flir data collected army test site summary work deep belief networks evolutionary approaches feature learning shown effective flgpr flir based ehd
chapter focuses analyze paraverbal communicative fluency teaching style essential paraverbal criteria related kinesics proxemics studied lecturers offering courses lessons analyzed using observational systems paraverbal communication socin soprox observational instruments enables broad analysis kinesics proxemics recording instrument used codify socin soprox lince software theme software used detect temporal patterns patterns observational data results reveal power teachers illustrative regulatory kinesics regulatory function makes use clearly defined kinesic gestures emblems kinetographs whereas illustrative function accompanied largely undefined kinesic gestures
conceptual paper reviews need family focused service delivery model within autism spectrum disorder asd field suggests double abcx model stress adaptation way address need within asd field absence service delivery models able address needs family unit rather individual child asd gap striking given reciprocal relationship parent child outcomes within asd field support argument double abcx model could used integrate parent child focused interventions within asd field paper starts reviewing mental health outcomes often associated child asd next provide historical overview double abcx model review body asd intervention literature within context double abcx model framework shows number child parent focused interventions within asd field fit within double abcx framework however handful methodological sampling limitations prevent double abcx model fully supported model could applied variety settings taken together review highlights double abcx model promising strategy integrate child parent focused interventions within asd field highlights specific areas future research needed order build continued support argument
controlled comparison trial evaluated suicide specific intervention collaborative assessment management suicidality cams extended stay psychiatric inpatient setting multiple outcomes examined patients half received individual therapy therapists trained cams comparison group selected larger pool propensity score matching ensure comparability age sex treatment program number prior suicide attempts severity suicidal ideation results showed patients improved significantly across wide range measures including depression suicidal ideation functional disability well gains durable month post discharge period patients treated cams trained individual therapist improved significantly admission discharge across measures differences cams non cams patients longer statistically significant month follow although statistical power compromised due attrition although replication studies needed findings suggest interventions specifically tailored suicidal patients may advantages compared usual intensive inpatient treatment perhaps addressing psychological vulnerabilities specific population lack significant differences follow suggest post treatment contact may needed maintain advantages associated similar interventions
cross cultural cross sectional study investigated italian children perceptions interethnic interracial friendships also known intergroup friendships total sample children attending two urban elementary schools middle sized northeastern city middle sized northern italian city interviewed employing questionnaire results indicate italian children perceptions intra racial interracial friendships differed students color rating intragroup friendships positively intergroup ones addition students color italy white students rated intergroup intragroup friendships similarly subjects education multicultural education childhood
cross sectional study conducted prisons city salvador bahia brazil investigated association presence psychiatric disorders prisoners types crimes committed psychiatric diagnosis obtained means brazilian portuguese version mini international neuropsychiatric interview statistically significant association found psychiatric disorders specific groups crime lifelong substance addiction sex crimes homicide antisocial personality disorder robbery kidnapping extortion borderline personality disorder sex crimes lifelong alcohol addiction fraud conspiracy armed robbery murder concluded mental disorders considered severe psychosis bipolar disorder associated violent crimes suggesting severity psychotic disorder may factor caused psychosis associated violent crimes previous studies
cross sectional study investigated association modified american heart association diet lifestyle recommendations aha dlr bone mineral density chinese adults found better adherence aha dlr associated higher bone mineral density bmd multiple sites accumulating evidence shows cardiovascular disease cvd osteoporosis associated yet little research focused whether strategies reduce cvd risk could also benefit bone health aimed assess association adherence modified american heart association diet lifestyle recommendations aha dlr bmd chinese adults included women men aged years community based cross sectional study dietary information assessed using item food frequency survey face face interviews baseline years later adherence aha dlr assessed using modified diet lifestyle scores american heart association diet lifestyle score aha dls adjusted bone health bmd whole body lumbar spine total hip femur neck trochanter sites measured using dual energy ray absorptiometry adjusting potential covariates greater adherence modified aha dls positively dose dependently associated bmd mean bmd higher quartile values multiple sites five unit increases modified aha dls score associated increases bmd multiple sites total subjects males females respectively values better adherence aha dlr shows protective associations bmd multiple sites middle aged elderly chinese population
cross sectional study designed investigate extent genetic susceptibility targeting variants interleukin signalling pathways leading atopic disease early childhood evaluated involvement five single nucleotide polymorphisms arggln ilra ileval ilra glnarg control serum total antigen specific immunoglobulin levels furthermore analysed association changes gene expression five cytokines key roles inflammatory anti inflammatory immune response interferon ifn total antigen specific ige levels serum gene expression selected cytokines peripheral blood measured children aged years taqman allelic discrimination amplification refractory mutation system polymerase chain reaction arms pcr restriction fragment length polymorphisms rflp methods validated sequencing used genotyping genotypes children total antigen specific ige levels normal range hardy weinberg equilibrium gene expression analyses carried using taqman gene expression assays found elevated total ige levels carriers arggln variant allele odds ratio confidence interval effect apparent boys however significant association observed four variants examined found regulation ifn children elevated serum total ige levels carrying arg allele differences found gene expression detection limit arggln genotypes play role genetic susceptibility allergy via regulation serum total ige levels affecting ifn gene expression
descriptive study evaluates dance movement psychotherapy dmp works patients fibromyalgia analysing psychotherapeutic process second objective considered effects dmp pain stiffness fatigue anxiety depression lifestyle changes study includes patients diagnosis primitive fibromyalgia referred individual dmp psychological distress related pain self assessment questionnaires administered intervention data analysed using simple regression model student test despite limitations study highlights changes many areas relationship self others symptoms fibromyalgia seem decreased results statistically significant patients used movement means expression despite pain disabling symptoms low drop rate suggests approach could useful difficult develop therapeutic alliance
essay provides practical advice transparent reproducible data analysis writing note research way today improve cumulation knowledge within discipline also improve life researcher tomorrow organize argument around series homilies lead concrete actions data analysis computer programming data analyst island long territory data analysis requires maps version control prevents clobbering reconciles history helps organize work testing minimizes error work reproducible research ought credible communication
essay reinterprets frank norris novel mcteague story san francisco depiction annihilating effects entropy human material systems focusing mcteague lengthy underanalyzed conclusion mcteague flees heart death valley argue norris descriptions desert identify irresistible destructive force guiding disintegration individuals relationships ultimately earth drawing record cultural anxieties surrounding laws thermodynamics nineteenth century essay demonstrates mcteague exemplifies apocalyptic posthumanism implications far disruptive human exceptionalism traditional biological determinism essay also interprets social biological material systems novel attempting unsuccessfully resist entropic decline channeling diversifying forces systems resembling electrical circuits context gold read current currency subtending california economic social worlds also drives greater greater states entropic disorder eventual collapse
ethnographical study aims interpret intelligent tutorial system geogebratutor mediates student argumentative processes data consisted four geometrical problems proposed group four students aged qualitative analysis two selected cases led identification development argumentative competences students well level influence produced regards influence geogebratutor students study revealed interactions tutor teacher student produced significant number mathematical learning opportunities thinking strategically type establishing figural inference conjectures fostering transition empirical deductive argumentations
experiment manipulated elite endurance cyclists implicit beliefs nature decision making ability explored subsequent change performance decision making task submaximal physiological load total elite level endurance cyclists women men manipulated endorse limited susceptible depletion nonlimited unsusceptible depletion implicit belief decision making ability results showed manipulation cyclists assigned limited resource condition higher levels limited beliefs lower levels nonlimited beliefs assigned nonlimited resource condition limited resource condition also showed decrease decision making performance whereas nonlimited resource condition showed increase decision making performance findings suggest implicit beliefs decision making ability manipulated elite sport sample manipulation alter performance decision making task submaximal physiological load
exploratory study utilized concurrent triangulation mixed methods design investigate parents respond considerate engaging forms children prosocial behavior whether prosocial behaviors likely receive reinforcement whether reinforcement associated specific types prosocial behavior parents preschoolers completed questionnaire regarding child general prosociality provided open ended responses prosocial vignettes completed questionnaire assessing reinforcement open ended responses showed reinforcement highly variable across parents prosocial behaviors across open ended response option formats social reinforcement responses parent approval character attributions showing love emerged common reinforcement responses prosocial behavior evidencing similar relationships comforting cooperating behaviors results suggest multiple ways parents respond child prosocial behaviors many seem attempts encourage prosociality
investigation explores effectiveness marketing cooperation compared sales cooperation new product development different market organizational circumstances business business settings using cross industry dyadic data set industrial firms show effects marketing sales cooperation new product advantage vary significantly depending velocity market environment company strategy characteristics specifically marketing cooperation exhibits stronger association new product advantage firms follow cost leadership strategy holds high power levels regarding new product decisions collectivism strongly pronounced conversely sales cooperation exhibits stronger effect new product advantage technological turbulence pronounced market firm follows differentiation strategy influential firm wide budgeting decisions results may help firms decide cooperation type might encouraged maximize innovation success given situation elsevier rights reserved
survey certain geometric aspects inviscid incompressible fluid flows described solutions euler equations review arnold theorem topological structure stationary fluids compact manifolds moffatt theorem topological interpretation helicity terms knot invariants recent realization theorem enciso peralta salas vortex lines arbitrarily complicated topology stationary solutions euler equations also introduced aim paper provide detailed proofs stated results introduce main ideas methods behind certain selected topics subject known topological fluid mechanics set lecture notes author gave xxiv international fall workshop geometry physics held zaragoza spain september
first report myophage infects arthrobacter novel virus artm arv arv isolated soil using arthrobacter strain phage propagation transmission electron microscopy showed resemblance members family myoviridae arv isometric head similar diameter contractile nonflexible tail similar phylogenetic comparative sequence analyses however revealed arv genes common phages family siphoviridae myovirus characterized date genome arv linear circularly permuted double stranded dna molecule content genome includes open reading frames orfs yet contains trna genes arv genes encode unique proteins either reliable identity database entries homologues arthrobacter phages sipho myoviruses using bioinformatics approaches arv structural genes identified including coding head tail tail fiber baseplate proteins arv orfs annotated encoding putative structural proteins based results proteomic analysis phylogenetic analysis based alignment four conserved virion proteins revealed arthrobacter myophages form discrete clade seems occupy position somewhat intermediate myo siphoviruses thus data presented help advance understanding genetic diversity evolution phages constitute order caudovirales importance bacteriophages likely originated early precambrian era represent numerous population planet approximately known phages tailed viruses comprise three families podoviridae short tails siphoviridae long noncontractile tails myoviridae contractile tails based current hypothesis myophages may evolved siphophages thought first emerged among gram negative bacteria whereas emerged later among gram positive bacteria results molecular characterization myophage artm arv presented conform aforementioned hypothesis since glance bacteriophage artm arv appears siphovirus possesses seemingly functional contractile tail work demonstrates chimeric myophages cosmopolitan nature likely characteristic ecologically important soil bacterial genus arthrobacter
first study examine clinical human bone specimens three dimensional imaging characterize osteocyte lacunar properties function macroanatomic bone type estrogen loss applied laboratory based instrumentation ray microscope dxrm microxct carl zeiss xradia inc reaches resolution synchrotron microscopy used serial transiliac bone biopsy specimens examine effect macroanatomic bone type estrogen status osteocyte lacunar properties properties include lacunar size volume axes lengths ellipsoidal lacunar voids distribution density average near neighbor lacunar distance shape factors sphericity ratio average eigenvalues degree equancy elongation flatness cortical trabecular bone tissue lacunar properties volume surface area density near neighbor distance etc shape factors degree equancy degree elongation different cortical trabecular bone regardless estrogen status cortical bone trabecular nodes lacunar void volume surface area either smaller tended smaller postmenopausal compared premenopausal women void volume bone volume ratio cortical bone showed declining trends estrogen loss differences trabecular cortical bone tissue lacunar void sphericity ratio trabecular struts shows decreasing trends postmenopausal women data suggest using dxrm provide new insight osteocyte lacunar properties transiliac bone biopsies patients various skeletal disease conditions pharmaceutical treatments
first systematic review synthesize evidence concerning early postoperative variables predictive later weight psychosocial outcomes bariatric surgery eight electronic databases empirical studies searched included studies reported solely weight outcomes eating psychosocial outcomes less common better early weight loss trajectory consistent predictor successful medium term weight outcome months however relationship longer term weight loss maintenance less certain early eating adaptation may associated later weight loss research needed evidence lacking associations early adherence early psychosocial variables later outcome particular relationship early post operative depression later weight remains unclear little research considered early prediction later eating psychosocial outcomes consideration mediating moderating relationships lacking body evidence limited synthesis hampered heterogeneity type time predictors outcomes measured quality statistical reporting research prospective prediction bariatric surgery outcome needed guide early post operative intervention greatest risk poor outcomes
second series two papers presenting reliability based methodology quantify financial risks involved engineering process systems operation represented flow discrete entities component process chain abstracted risk item logic based finite automata incorporated model transition states failure maintenance failure lead time process operation abstracted model composed several servers queues employs discrete event simulation techniques illustrate proposed method model applied case copper ore production system risk profile characterised multi objective evolutionary algorithms used optimise models obtain pareto optimal set solutions different risk profiles kind queuing theory based modelling used represent many types systems like production engineering supply chain management manufacturing engineering logistics etc hence risk model easily adapted different disciplines minor modifications
large dose ranging study explored benefits different combinations mirabegron solifenacin health related quality life hrqol based patient reported outcomes pros patients responders achieving clinically meaningful improvements efficacy hrqol symphony nct phase placebo monotherapy controlled dose ranging week trial adult patients overactive bladder oab months randomized groups combination solifenacin mirabegron monotherapy solifenacin mirabegron placebo change baseline end treatment assessed versus placebo solifenacin pros oab symptom bother total hrqol patient perception bladder condition score responders achieving minimally important differences mids pros predetermined clinically meaningful improvements efficacy micturitions changes pros responders analysed using ancova model logistic regression respectively full analysis set included patients combination therapy solifenacin mirabegron significantly improved pros versus solifenacin placebo significantly responders achieved mids pros efficacy micturition frequency normalization approximately twofold greater versus solifenacin combining mirabegron solifenacin improves objective subjective efficacy outcomes compared placebo solifenacin
letter describes continued optimization nam valuable vivo tool compound excessively long elimination half life rat problematic certain rodent addiction paradigms reinstatement thus required nam comparable potency rat less steep sar plagued chemotype detail aniline replacements offered improvements failed advance ultimately incorporation single methyl group phenyl ring acted metabolic shunt providing equipotent nam high cns penetration excellent selectivity versus desired short half life rat elsevier ltd rights reserved
letter develops single hop fast accurate energy efficient time synchronization protocol wireless sensor networks protocol designed operate harsh environments based resistive electrical network metaphor treats nodes times states discrete decentralized unconditionally stable dynamical system synchronizer monitors evolution states transient phase determine instant time encoded state close master node time procedure yield high quality time estimates accuracies fractions communication cycle synchronization method developed capabilities demonstrated simulation physical experiments mica wireless sensor network
note shows certain grobner basis methods developed multidimensional systems applied parameter dependent one dimensional systems linear behavioral systems nonlinear state space systems discussed
paper addresses joint downlink uplink aware cell association problem multi tier heterogeneous network base stations bss finite number resource blocks rbs distribute among users optimization problem defined maximize sum weighted utility long term data rate downlink uplink cell association distribution maintaining quality service qos separate outage requirements considered qos constraints downlink uplink user using outage qos constraints renders problem suitable fast fading environments propose distributed scheme cell association problem users measure uplink attributes listening reference signals bss limited amount feedback added reference signals bss inform users uplink interference make distributed algorithm design possible moreover assigning different weights downlink uplink data rates proposed scheme downlink oriented uplink oriented downlink uplink aware comparing proposed scheme downlink oriented maximum signal interference plus noise ratio sinr scheme significant uplink rate gains observed simulations well downlink rates
paper addresses evaporation vacuum condition aid solar energy recovered waste heat vacuum pump preliminary attempt design innovative solar based evaporation system vacuum design details equipment required theoretical background work methodology covered article theoretically based energy provided sun day production rate pure water around day assumptions made worst case scenario latent heat evaporation recycled ability dark droplet absorb sun energy around waste heat pump heat collected photovoltaic panels proposed raise temperature inlet water system boiling point selected reduced pressure elsevier rights reserved
paper addresses key features satellite component imt advanced systems including candidate system architectures service scenarios candidate radio interfaces consider integrated hybrid satellite terrestrial networks efficient means meet main service requirements satellite component satellite bandwidth scarce resource efficient frequency reuse techniques play important role successful deployment service reason propose efficient frequency reuse technique designed integrated satellite system support imt advanced services proposed scheme satellite terrestrial components effectively share bandwidth copyright john wiley sons ltd
paper addresses preliminary steps toward modeling qualitative analysis swarms viewed living complex systems approach based methods kinetic theory statistical mechanics interactions microscopic scale nonlocal nonlinearly additive modeled theoretical tools stochastic game theory collective learning theory play important role modeling approach present kinetic equation incorporating cucker smale flocking force stochastic game theoretic interactions collision operators also present sufficient framework leading asymptotic velocity alignment global existence smooth solutions proposed kinetic model special kernel analytic results global existence flocking dynamics presented last part paper looks ahead research perspectives
paper addresses continuing problem united states lack female professionals computer science research team conducted surveys middle school students working adults examine attitudes motivations experience computer science based survey findings researchers able evaluate effects early positive exposure computer programming give recommendations improve attitudes confidence young girls toward possible career computer science
paper addresses global finite time regulation problem robotic manipulators simple nonlinear proportional integral derivative pid control proposed adding nonlinear proportional derivative term commonly used pid controller lyapunov stability theory geometric homogeneity technique employed prove global finite time stability advantages proposed control include absence modelling information control law formulation global finite time stability featuring fast transient high precision positioning explicit conditions controller parameters ensure global finite time regulation stability obtained simulations presented demonstrate effectiveness improved performances proposed approach
paper addresses impact electrode contaminations interfacial energy level alignment molecular conformation orientation surface morphology deposited organic film organic semiconductor noble metal interfaces varying film thickness sub monolayer multilayer currently draws significant attention regard application organic electronics uhv clean unclean employed substrate whereas rubrene used organic semiconducting material photoelectron spectroscopy xps ups engaged investigate evolution interfacial energetics polarization dependent near edge ray absorption fine structure spectroscopy nexafs employed understand molecular conformation well orientation whereas atomic force microscopy afm used investigate surface morphologies films adventitious contamination layer acted spacer layer clean substrate surface rubrene molecular layer consequence hole injection barrier height interface dipole well molecular conformation molecular orientation surface morphology rubrene thin films found depend cleanliness substrate results important inferences understanding impact substrate contamination energy level alignment molecular conformation well orientation surface morphology deposited rubrene thin film rubrene interfaces beneficial improvement device performance elsevier rights reserved
paper addresses problem augmented reality images acquired non central catadioptric systems propose solution allows projection textured objects images type systems depending complexity objects run fps using image resolution main contributions related image formation non central catadioptric cameras projection segments onto image non central catadioptric cameras occlusions illumination shading validate proposed solution used non central catadioptric camera formed perspective camera spherical mirror also test robustness proposed method used regular object parallelepiped three well known irregular objects computer graphics bunny happy buddha dragon stanford database
paper addresses problem developing user interfaces ubiquitous computing ambient intelligence ami systems kind systems expected provide natural user experience considering interaction modalities adapted user abilities preferences using whatever interaction devices present environment interaction devices necessarily known design time task quite complicated due variety devices technologies diversity scenarios usually burdens developer need create many different uis order consider foreseeable user environment combinations propose abstraction framework ami systems effectively improves portability systems different environments different users allows developers design implement single capable deployed different devices modalities regardless physical location
paper addresses self interference cancellation full duplex radio transceiver particular focus shared antenna based full duplex transceivers self interference coupling channel always frequency selective also strongly time varying depending antenna matching characteristics reflections surroundings novel digitally controlled self interference canceller structure described able process signals frequency selective manner well track adaptively time varying features stemming fast digital control loop complete demonstrator board developed reported measured incorporating processing digital control processing comprehensive measurements also carried reported ghz ism band evidencing dbs active cancellation gain mhz instantaneous waveform bandwidths furthermore real time self adaptive tracking features successfully demonstrated
paper aims using decision tree method predict student performance one core engineering courses strength materials three research questions taken consideration student performance predicted using decision tree student score prerequisite course current semester cumulative gpa play significant role student performance throughout related course decision tree predict accurate traditional regression techniques artificial neural network multivariate linear regression believed study helpful researchers lecturers gap found literature applications results methods shown decision tree powerful tool predict student performance core course
paper aims indicate relationships women work observation almanachs pelotas taking specific elements analysis texts photographs ads aforementioned publication edited annually circulated pelotas years main objective divulge modern progress city woven observations female work promulgated cited elements also suggested delimitation periodic public mainly male conservative may explain discourses around ideal women housewives cases outside home work limits based assignments gender roles discusses text historical invisibility women issue one hand notorious almanachs paradoxically visibility afforded enable analysis possible works women hence title article placed dubious way fact periodical consideres issues
paper analyses evaluates parallel implementations optimization algorithm perishable inventory control problems iterative algorithm high computational requirements solving large problems therefore use parallel distributed computing reduces execution time improves quality solutions work investigates two implementations heterogeneous platforms mpi pthreads version multi gpu version comparison implementations carried experimental results show benefits using parallel distributed codes solve kind problems furthermore distribution workload among available processing elements challenging problem distribution tasks modelled bin packing problem implies selection set tasks assigned every processing element requires design heuristic capable efficiently balancing workload statically significant overhead heuristic used parallel implementations optimization perishable inventory control problem elsevier inc rights reserved
paper analyses influence selected magnet materials design slow speed permanent magnet synchronous generators use wind applications design procedure including setting initial design parameters machine calculations machine dimensions magnetic flux air gap electrical parameters well selection criteria permanent magnets use permanent magnet generator presented according calculations generator prototype constructed four different rotors different magnetic materials used machine tested using different rotors influence different magnetic materials output characteristics machine shown price power analysis used magnetic materials provided conclusions possible machine design benefits drawbacks presented study investigations carried show ndfeb magnets preferred ones terms performance weight reduction whereas considerable alternatives available design performance criteria flexible
paper analyzes impact change thermal insulating material energy environmental performance building evaluated two different green building assessment methods leadership energy environmental design leed istituto per innovazione trasparenza degli appalti compatibilita ambientale itaca leed one qualified rating systems international level assesses building sustainability thanks point based system credits divided six different categories one fully related building materials itaca procedure derives international evaluation system sustainable building tool sbtool modified according italian context region umbria itaca certification composed technical sheets classified five macro areas analysis developed residential building located central italy built taking account principles sustainability far structural technical solutions concerned order evaluate influence thermal insulating material different configurations envelope considered replacing original material glass wool synthetic one expanded polystyrene eps two natural materials wood fiber kenaf study aims highlight materials characteristics affect building energy environmental performance point different approaches analyzed protocols
paper analyzes possibility substitute gray iron traditionally used production relevant parts woodworking machines ductile iron vermicular iron large experimental campaign determine mechanical beavior ductile vermicular irons respect tensile fatigue fracture loads conducted microstructures also analyzed results show ductile vermicular cast iron parts components machine tools could provide additional stiffness resistance high precision woodworking respect gray iron balanced utilization alternative irons would permit take full advantage specific property strength hardness weight etc
paper analyzes transaction prices green buildings assessed basis multiple green factors theoretical model demonstrates initial green premium negative becomes positive building ages green building higher life cycle cost longer economic life empirical analysis green condominiums tokyo confirms prediction additionally find longer life design associated price premium use renewable energy recycled materials water associated price discounts price discounts interpreted capitalization greater life cycle user cost
paper approaches problem output power prediction shore wind park end called wind deficiency factor turbine wind direction sector identified using past data identification done using effective wind speed concept establish link output power wind turbine meteorological mast measures terms wind speed direction based forecast wind speed direction wind park simulator uses previously identified deficiency factors computes future output power time evolutions nunierical simulations show feasibility proposed approach elsevier ltd rights reserved
paper argues implicit self stereotyping moderated potential social evaluation situation hypothesized implicit self stereotyping facilitated social cues gaze cues signal social evaluation study examined whether gaze cues affected implicit self stereotyping related gender stereotypes regarding math competence pilot study demonstrated presentation direct gaze cues averted gaze cues signaled social evaluation social norms main study revealed gender differences math identity prominent direct gaze cues relative averted gaze cues women showed negative math identity men exposed direct gaze cues exposed averted gaze cues moreover effects particularly prominent among women stronger implicit math gender stereotypes female identity findings improve understanding implicit self stereotyping occurs social situations
paper brings forth literature series learning curve models evaluates lens construction industry review suggests still consensus model provides best fit predictability construction data paper puts forth new model suitable modern construction industry accommodates mechanization forgetting proposed model similar wright model exponential model learning recursion places emphasis recent data proposed model shows error less predicting cumulative average completion times three four cases examined
paper concerns net effects promoting renewable energies value added disposable income germany well distribution among regions income brackets since entry force german renewable energy sources act eeg stimulated tremendous investments renewable energy capacities guaranteeing investors fixed price per kwh well preferred feed grid electricity conventional sources policy measures financed surcharge electricity prices recent years controversy arisen potentially negative regional social distribution effects paper multiregional price quantity input output models endogenous heterogeneous households used trace indirect impacts eeg value added disposable income complex network regional value chains findings suggest generation electricity renewable sources leads small positive impacts industries leads significant drain household income regressive distributive effects however investment new capacities may possibly transform negative impacts positive direction majority households elsevier rights reserved
paper considers relational databases containing uncertain attribute values knowledge available themore less certain value disjunction values given attribute tuplemaytake propose possibility theory based model suited context extend operators relational algebra handle relations compact thus efficient way shown model representation system whole relational algebra important result data complexity associated extended operators context classical database case makes approach highly scalable
paper contributes field low power high order cmos log domain filters suggesting log domain synthesis path bypasses need minus cells assessing practicality proposed synthesis path means order cmos log domain bessel filter fabricated commercially available ams process measured results bessel filter chip confirm validity proposed approach filter reported particularly useful biomedical instruments portable ecg devices pulse oximeters elsevier ltd rights reserved
paper deals model based design autonomous biomechatronic device sensing analog signal processing acoustic signals aim develop biomechatronic artificial cochlear implant people hearing loss due damage disease cochlea unique artificial electronic cochlear implant based array microelectromechanical piezoelectric membranes oscillations membranes detect filter acoustic signals individual acoustic frequencies proposed biomechatronic device artificial cochlear implant consists active filters array signal processing electronics stimulation nerves electrodes energy harvesting system autonomous powering device solution differs current cochlear implants solutions bulky electronic systems limited high power consumption multidisciplinary models artificial cochlea implant concept presented mechatronic approach based model seems useful development full implantable cochlear implant designed sensing processing acoustic signals without external energy source elsevier ltd rights reserved
paper deals design pid controller use methods global optimization implemented matlab environment optimization toolbox based minimization chosen integral criterion respect additional requirements control quality overshoot phase margin limits manipulated value objective function also respects user defined weigh coefficients particular terms different penalization individual requirements often clash example overshoot phase margin described solution designated continuous linear time invariant static systems order thus efficient real control processes practice
paper deals measurement evaluation electromagnetic noise generated induction electric motor fed inverter controlled pwm suggests describes possible method evaluation electromagnetic noise used real time applications
paper deals performance improvement pendulum cart system pcs using fractional controller simpler control structure stabilization pcs proposed control structure consists two fractional order proportional integral derivative fopid controllers designed basis fractional order calculus foc one controls cart position one controls pendulum angle foc provide higher performance extension fopid controllers however designing fopid controllers hard controllers two parameters derivative integral order design comparison traditional proportional integral derivative pid controllers designing fopid controllers used new toolbox matlab fractional order modeling control fomcon provides set tools fractional order control proper parameter tuning fopid controllers done trial error approach performance pcs successfully designed fopid controllers analyzed means transients also compared performance conventional pid controller pcs comparison ensures improvement fopid controller
paper deals design modeling simulation two electrical circuits devoted kinetic piezoelectric energy harvesters powering distributed control cells two schemes proposed analyzed discussed first based classical electrical stages second integrates novel multiplier rectifier stage permits reduce voltage loss simulation experimental tests carried demonstrate advantage second scheme relative first one
paper deals evaluation analysis bottoming orc cycle coupled engine means conventional advanced exergy analysis using experimental data orc coupled turbocharged engine conventional advanced exergy analysis carried splitting exergy advanced exergy analysis unavoidable avoidable provides measure potential improving efficiency component hand splitting exergy endogenous exogenous provides information interactions among system components result study shows high potential improvement type cycles although conventional analysis exergy destruction rate boiler greater one expander condenser pump advanced exergy analysis suggests first priority improvement given expander followed pump condenser boiler total amount exergy destruction rate could lowered taking account avoidable part exergy destruction rate reduced elsevier ltd rights reserved
paper deals load frequency control lfc study single area interconnected two area power system diversified power sources two areas considered present study identical area thermal hydro gas based power plants split shaft model gas turbine used present work one diversified generating unit purpose lfc study optimal gains classical controllers like integral controller proportional integral controller pro portional integral derivative pid controller one installed time studied models obtained using novel music inspired metaheuristic harmony search algorithm hsa incorporates quasi opposition based learning technique memory initialization also generation jumping single area power system diverse power sources considered optimal transient performances obtained compared step load perturbation approach extended two area interconnected power system consisting diverse power sources nominal values area input parameters performance pid controller found best one studied power system models also revealed performance interconnected two area power system tie line better comparison tie line elsevier ltd rights reserved
paper deals motion analysis skier gliding actual snow field using inertial sensors difficult measure motion skier gliding actual snow field since gliding velocity fast measurement area large therefore studies analyzed ski turns gliding actual snow field necessary analyze skier gliding actual snow field resolving mechanism ski turns previous study developed motion measurement method skier using inertial magnetic field sensors posture estimated applying sensor fusion method method estimate posture compensating drift error gyro sensor reducing effect dynamic acceleration accelerometer furthermore developed sensor fusion method estimating posture local coordinate information inertial sensors attaching body segments joint angle skier gliding actual snow field estimated method inverse kinematics conducted measurement experiment skier gliding actual snow field inertial sensors gps receiver attached body segments top skier respectively skier conducted carving skidding turns experiment calculated joint angles skier information inertial sensors switchovers turns estimated gps receiver output results motion analysis indicated major feature skier motion difference carving skidding turns therefore analysis results used skill rating clarification mechanism ski turns suggestion ideal turning form authors published elsevier ltd selection peer review responsibility school aerospace mechanical manufacturing engineering rmit university
paper deals problem non fragile robust finite time infinity control class uncertain nonlinear stochastic ito systems via neural network first applying multi layer feedback neural networks nonlinearity approximated linear differential inclusion ldi state space representation sufficient condition proposed existence non fragile state feedback finite time infinity controller terms matrix inequalities furthermore problem non fragile robust finite time infinity control reduced optimization problem involving linear matrix inequalities lmis detailed solving algorithm given restricted lmis finally example given illustrate effectiveness proposed method
paper deals real implementation event based control structure classical rotary inverted pendulum communication controller plant performed ethernet tcp leads networked control system bandwidth used control loop reduced compared one needs conventional control using threshold based communication values thresholds determined means simulation techniques results real plant show technique reach significant reduction bandwidth consumed negligible worsening performance isa published elsevier ltd rights reserved
paper deals theoretical analysis performance solar air collector duct packed optically semitransparent materials heat transfer equations two dimensional fully developed fluid flows quasisteady state conditions developed order analyze thermal thermo hydraulic exergy performance study effect system operating parameters computer programme developed language estimate temperature rise entering air evaluation performance solving governing equations numerically using relevant correlations heat transfer coefficient packed bed systems results air temperature rise thermal efficiency obtained analysis compared available experimental results results found fairly closed agreement found considerable enhancement thermal efficiency packed bed collector effect total bed depth efficiency show upper limiting value total bed depth beyond thermal efficiency begins fall type characteristics behavior observed mass flow rate also noticed exists optimal value effective exergy efficiencies given mass flow rate
paper demonstrates multi plate ion balance analyzer inverse distance weighted interpolation characterizing ionizer performance proposed analyzer design uses ultra high input impedance charge induced meter measure electrostatic potential multiple ion receiving plates embedded microcontroller processes multi channel analog signals synchronously presents results graphical display data interpolation enables high resolution results multi plate measurements developed analyzer suitable ion balance characterization small footprint devices sensitive electrostatic discharges single chip integrated circuit head gimbals assembly hard disk drive elsevier rights reserved
paper describes complex hybrid terrestrial satellite mobile network includes satellite based network sbn ancillary terrestrial component atc components integrated via single logical standards based core network based gpp gpp network entities next generation session controls implemented across core transport network via ims core utilizing sip signaling two satellite air interfaces gmr satellite brpd shrpd operating geo satellite described main advanced features performance reviewed
paper describes course redesigned meet industry need product life cycle management plm literate workforce objective interdisciplinary course introduce students manufacturing engineering theories coupled industry sponsored project throughout building assembly line simulation students exposed topics including process design process verification workspace ergonomics moreover practices project management along theory critical chain built course end goal prepare students knowledge plm also capability problem solving communication self motivated teamwork leadership
paper describes high performing hybrid parallel heterogeneous algorithmic approach narrowband delay sum beamforming dsb frequency domain using time asynchronous data method jit adm parallel pattern jit adm novel asynchronous parallel programming pattern unifies various levels asynchronous concurrency available distributed heterogeneous computing computational performance dsb algorithm analyzed node cray single core intel xeon nvidia tesla general purpose graphics processing unit gpu node algorithm exhibits well behaved weak scalability percent parallel efficiency nodes compared maximum performance observed also shown algorithm efficiently utilizes large portion available hardware beamforming gpu utilized percent maximum double precision floating point throughput whereas comparable central processing unit cpu version utilizes percent maximum expected floating point throughput across weak scalability study utilizing gpus processing performance gain achieved compared using cpus brief derivation validation implemented dsb also presented
paper describes larger output torque production capability independent multi phase inverterfed electric motor drive automobile traction motor proposed method focuses radial tangential component flux density air gap investigation reveals output torque depends relationship flux density radial component tangential component particularly large flux density small phase difference increase output torque fea experimental results show proposed method produce larger output torque improve motor efficiency compared conventional sinusoidal current excitation
paper describes methodology perform chemical analyses landfill areas integrating multisource geomatic data used top approach identify environmental point interest epi based high resolution satellite data pleiades worldview situ thermal photogrammetric surveys change detection techniques geostatistical analysis supported chemical survey undertaken using accumulation chamber riia unmanned ground vehicle developed cnr iia equipped multiparameter sensor platform environmental monitoring approach improves site characterization identifying key environmental points interest necessary perform detailed chemical analyses elsevier rights reserved
paper describes multi institution effort develop data science service platform platform integrates advanced federated data management small large datasets access high performance computing distributed computing advanced networking goal develop platform flexible extensible still supporting domain research avoiding walled garden problem preliminary lessons learned next steps also outlined
paper describes new method deriving greater torques per unit volume permanent magnet machine configurations method involves splitting stator teeth order introduce magnetic gear ratio torque equation also theory mathematical equations behind design new split teeth machine shown descried two different initial designs new machine topology developed using two dimension finite element simulations compared convectional brushless machine dimensions gains output torques three machines designed shown purpose comparison
paper describes novel operational amplifier opa voltage controlled oscillator vco circuit used frequency range exceeding unity gain bandwidth vco topology based operational amplifier negative inductance converter oscillator architecture mathematical modeling simulation measurement results presented designed vco uses ultra low noise wideband opa lmh covers frequency band mhz ghz exhibits maximum band phase noise dbc mhz offset carrier frequency power consumption vco core power supply simulation results verified implementing oscillator generates low noise signal
paper describes study effects guided inquiry module instruction undergraduate construction engineering students understanding course concepts attitudes toward module instruction eighty one students two sections construction materials engineering course participated study sections received guided inquiry module instruction treatment three six course topics participants completed pre posttests topic exams midterm final questionnaire assess attitudes perceptions results study show students perceived module instruction effective traditional lecture students across sections indicated participated module instruction approach effective encouraging participation providing opportunities discussion activities teamwork additionally students performed better certain topic posttests treatment condition study contributes growing research effectiveness active instructional approaches engineering education improve student learning gains future research consider instructor teaching style class composition design experimental comparisons doi asce american society civil engineers
paper describes versatile composite amplifier current feedback amplifier cfa drives operational amplifier opa conventional opa cfa composite amplifier opa drives cfa resulting composite structure combines input stability opa high speed capability cfa proposed composite configuration combines different features cfa opa specifically constant bandwidth property cfa high power high current output capacity opa new circuit easily implemented standard inverting non inverting configurations using commercially available devices accuracy constant bandwidth features experimentally verified local feedback around associated cfa ensures proposed composite amplifier possesses higher level bandwidth constancy single cfa
paper describes approach assess measure trust based specific ambient intelligence environment primary aim work address expand line research investigating possibility measuring trust based quantifiable behavior present brief review existing definitions trust define trust context ambient intelligence ami scenario propose formal definition analysis trust kind scenarios developed thus suggested use ambient intelligence techniques use trust data model collect evaluate relevant information based assumption observable trust two entities parties results certain typical behaviors establish foundation prediction aspects based analysis people interaction technological environments providing new potentially interesting trust assessment tools
paper describes proposes modern solution controlling temperature crude oil atmospheric distillation programmable logic controller plc used instead classic proportional integral derivative pid controller authors present details design plc programme together simulation diagrams show designed control system works programming plc done using function block diagrams method
paper describes investigations magnetorheological elastomers subjected cyclic loading procedure comprised million loading cycles per specimen mechanical properties manufactured composites tendency stabilize time leads conclusion magnetorheological elastomers high application potential areas connected energy dissipation damping vibrations
paper describes macromodeling operational amplifiers overdrive circuit design macromodels applied operational amplifier simulations good convergence also macromodels allow accurate simulation double power supply also single power supply study macromodel applied overdrive circuit sound effect design output waveform using macromodel compared using pre set model double power supply experiment output macromodel shows accurate amplitude frequency distortion pre set model result macromodel operational amplifier suitable pre set model overdrive circuit design
paper describes selected results collected wind tunnel tests carried politecnico milano wind tunnel deck sectional model messina strait bridge long span suspension bridge characterized multi box deck aerodynamic forces surface pressure distributions measured order characterize static dynamic response deck vortex induced vibrations phenomenon studied particular attention represents one important aspects considered designing deck shape long span bridges carefully analyzed fact even separated stability problem modern bridges viv case low scruton numbers lead deck reach large vibration amplitudes also low wind speeds elsevier ltd rights reserved
paper describes analysis manufacturing engineering data integrated process manufacturing resources planning requirements recommendations data structures integration effective computerization manufacturing engineering presented examples data structure data base integrated computer aided manufacturing engineering system provided
paper describes construction system uses information several home automation devices detect presence person space devices located detection however rely information devices explicitly detect human presence like motion detectors smart cameras information used one available muzzley system mobile application allows monitoring control several types devices single program provided information anonymized source first step extract adequate features problem labeling step introduced using combination heuristics assert likelihood anyone home given time based information available including limited direct presence detectors solution rests mainly use supervised learning algorithms train models detect presence without information based direct presence detectors model able detect patterns usage owner home rather rely direct sensors results show detection context difficult believe results shed light possible paths improve system accuracy
paper describes design results low voltage high gain cmos operational amplifier amp appropriate low voltage analog mixed signal applications design based folded architecture amplifier designed using standard digital well cmos technology operate single supply simulated small signal gain amplifier slew rate capacitive ohm resistive load load gain bandwidth mhz phase margin degree amplifier consumes total power input referred noise sqrt furthermore presented operational amplifier works perfectly supply voltage
paper describes design cmos analog discrete time equalizer perpendicular magnetic recording pmr read channel design structure analog fir filter places rotating switch matrix dac multiplier proposed reduces accumulative switching error analog samples due rotating switch matrix tap filter circuit based gpr target designed simulated using tsmc cmos process parameters simulation results show good agreement results system level simulation ghz sampling frequency equalizer dissipates
paper describes design traffic assignment model predicts flows segment urban network higher resolution traditional four stage model retaining origins destinations travel research objectives determine traffic intensity specific areas network identify origins destinations travel predict changes urban mobility achieve objectives relational databases geographic information system transport environment used gis together data household intercept interviews identify mobility patterns middle sized city merida spain application programs detect changes mobility patterns locate problem areas results obtained show high degree adjustment predictions actual observations trips addition disaggregation levels midpoint section network combined population data adjustment using population pyramids avoid bias travel samples
paper describes design measurement methodology experimental validation electronic system monitoring electrical discontinuity rails double track railway lines order detect rail breakage electronic system based emitter node two receiver nodes three nodes together four rails analyzed constitute electrical circuits whose currents measured emission reception nodes nodes communicate data network well remote center controls synchronizes electronic systems along railway line electronic subsystem associated emitter node transmits encoded signal rails modulated carrier set eight currents measured one per rail end section defined emitter receiver maximum length evaluation electrical discontinuities section carried means relative imbalances appear eight measured currents according possible breakages method measurement characterized high immunity noise results presented based railway line prototype implements electrical propagation models coupling four rails double track model allows proposed electronic system measurement methodology successfully verified
paper describes development validation uses collaborative computing observation instrument coi web based analysis instrument classifies individual collaborative behaviors students computing problem solving coding programming coi analyzes data gathered video audio screen recording software captures students computer screens program conversations peers adults instrument allows researchers organize quantify data track behavioral patterns could analyzed deeper understanding persistence collaborative interactions article provides rationale coi including development theoretical framework measuring collaborative interactions computer mediated environments theoretical framework relied computer supported collaborative learning literature related adaptive help seeking joint problem solving space collaborative computing occurs conversations related outcomes products computational activities instrument development validation also included ongoing advisory board feedback experts computer science collaborative learning computing well classroom observations test constructs coi processes resulted instrument rigorous validation procedures high inter rater reliability
paper describes performance brain project distributed software tool formal modeling numerical data using hybrid neural genetic programming technique one interesting characteristics brain project distributed implementation unlike many parallel distributed solutions requirement brain project collaborating personal computers must bit linux machines connected internet via transmission control protocol internet protocol performance brain project clearly enhanced simple parallelization scheme illustrated paper although brain project presents many innovative solutions genetic programming research paper focuses mainly behavior distributed environment elsevier rights reserved
paper describes real estate development projects management investor point view explaining management complicated business competitive environment needs smart solutions authors chosen managing tools help private developers drive successfully projects paper discuss organization chart project team basic division project timeline detailed stages role relatively new members like foreign architect external construction manager authors employed one biggest central european development company share experience different projects slovakia czech republic
paper details design considerations permanent magnet three phase synchronous machine fault tolerant operation multidisciplinary approach optimal design machine adopted targeted minimizing additional losses resulting faulty operating conditions accounting remedial control strategy implemented design closed slot six slot four pole machine presented machine prototyped tested validate analytical computational performances predicted design analysis stage healthy faulty conditions
paper discusses design interface nuclear new hybrid message passing architecture embodied humanoid robotics nuclear modular low latency promotes functional expandable software design greatly reduces latency messages passed modules message routes established compile time also reduces number functions must written using system called messages aids dealing multiple simultaneous data nuclear primarily evaluated humanoid robotic soccer platform robotic boat platform evaluations show nuclear requires fewer callbacks cache variables existing message passing architectures nuclear limitations applying techniques multi processed systems performs best lower power systems computational resources limited article aims readers interest modern software engineering concepts development systems areas robotics smart devices virtual reality
paper discusses development modeling approach reactive energy management objective reactive energy management adopt long term anticipated performance actual situation preserving occupant comfort energy expenses performs continuous performance monitoring whole building taking account unplanned events system failures reactive energy management mechanism uses fast dynamics models short time simulation able manage real time observations sensor data work emphasizes development low order resistance capacitance thermal model equivalent state space representation end case study demonstrates significance fast dynamics reactive models detect discrepancies reality published elsevier ltd
paper discusses development new winding configuration six phase permanent magnet machines slots poles eliminates reduces undesirable space harmonics stator magnetomotive force proposed configuration improves power torque density efficiency reduction eddy current losses rotor permanent magnets copper losses end windings improve drive train availability applications electric vehicles evs paper proposes design six phase machine two independent three phase windings number possible phase shifts two sets three phase windings due slot pole combination winding configuration investigated optimum phase shift selected analyzing harmonic distributions effect machine performance including rotor eddy current losses machine design optimized given set specifications evs electrical thermal volumetric constraints demonstrated experimental measurements prototype machine
paper discusses evolution longitudinal train dynamics ltd simulations covers numerical solvers vehicle connection systems air brake systems wagon dumper systems locomotives resistance forces gravitational components vehicle train instabilities computing schemes number potential research topics suggested modelling friction polymer transition characteristics vehicle connection simulations studies wagon dumping operations proper modelling vehicle train instabilities computing schemes ltd simulations evidence shows ltd simulations evolved computing capabilities currently advanced component models directly describe working principles operation air brake systems vehicle connection systems traction systems available parallel computing good solution combine simulate advanced models parallel computing also used conduct three dimensional long train dynamics simulations
paper discusses use low gain amplifier passive switched capacitor network enable integrator function method applied delta sigma modulator achieve high resolution proved cmos technology test vehicle compared conventional operational amplifier amp based integrator solution utilizes low gain open loop amplifier drive passive integrator positive feedback since open loop amplifier requires low gain implements embedded current adder power consumption low power reduction single bit obtained using passive feed forward built adder assist first amplifier low swing obtained output active blocks relaxes slew rate requirement enhances linearity implemented digital cmos technology active area test chip achieves dynamic range peak signal noise ratio peak signal noise plus distortion ratio spurious free dynamic range consuming khz signal bandwidth supply yielding fom walden conv step fom schreier
paper examines expressions experiences internalised sexual stigma respect definitions masculinity identity conflicts thematic analysis life history narratives self identified gay men living turkey analysis reveals internalised sexual prejudice emerges widely accepted hegemonic masculinity ideology violated gay participants narratives indicate construction masculinity vigorous process established via encounters hegemonic masculinity findings discussed context relevant literature relation turkish culture traditional understanding gender gender roles
paper examines conditions global dominant innovation design considering mobility emergence lead market different countries development lead markets linked multiple country specific factors influence lead market potential position decreasing national differences time benefits best compromise internationally similar innovation design due early market entry firms reach first mover advantages protect followers especially eco innovations could reach state global dominant design developed tackle climate change development globally sold mobility products electric motor battery whole vehicle likely therefore strategy strengthen lead market mobility seems promising help principal component analysis pca different country specific indicators applied model five lead market factors lead markets change quickly given theoretical concept estimating opportunities forecasting technology developments evaluation usa obtain lead market position according mobility followed germany france advantage usa mainly result demand incentives large sales market germany supply side indicators pronounced position france mainly results well advanced supply demand side measures average
paper examines design implementation eighth order bandpass delta sigma modulator design process investigated signal flow graph level details switched capacitor implementation layout considerations simulation results highlighting effects process variation provided experimental performance modulator described modulator implemented bicmos process occupies active area operating supplies fabricated prototype exhibits stable behavior achieves dynamic range khz bandwidth centered commonly used intermediate frequency mhz paper therefore demonstrates viability high order single bit bandpass delta sigma modulation
paper examines electoral ideological contest taken place welsh labour plaid cymru five national assembly elections held parties found success managed combine effective leadership coherent programme strong sense welsh identity however welsh vote leave june referendum dealt parties poor hand speaking welsh interests find common cause working together also scotland take wales forward progressive constitutional direction
paper examines indexical chronotopic meanings two korean kinship terms oppa older brother woman nwuna older sister man emerge south korean popular culture kinship terms commonly used south korean society address siblings tropical sense address intimates superior age speaker extending romantic contexts paper demonstrates oppa nwuna become chronotopic spaces negotiation traditional korean morals gender roles tied status intimacy indexed forms new competing discourses gender equality free love consumerism enlightenment crucially analysis shows underlying kinship metaphors contained oppa nwuna play crucial role negotiating balance modernity tradition particularly depiction sex romance korean popular culture packaging romance sex within idiom kinship sexual desires fantasies rendered innocent pure obscured altogether thus allowing korean popular culture escape censure overtly sexually provocative elsevier ltd rights reserved
paper explores biographical cultural sources inspired decision janusz korczak warsaw treblinka make life vocation education young children dysfunctional families decision emerged radical version humanism embraced identification children population humanist ethos must serve distinguishes versions humanism paper explores role sense self identification poles jews humanity play composition humanism identifies hybridity cultural identifications heart proposes tensions identifications general non jewish jewish identification situated part apart polish society particular induced korczak create universal religion children religious ethnic physical distinctions generate prejudice intolerance violence
paper explores effects emotions embedded seller review perceived helpfulness readers drawing frameworks literature emotion cognitive processing propose well known negativity bias impact discrete emotions review vary one source variance reader perceptions reviewers cognitive effort focus roles two distinct negative emotions common seller reviews anxiety anger first two studies experimental methods utilized identify explain differential impact anxiety anger terms perceived reviewer effort third study seller reviews yahoo shopping web sites collected examine relationship emotional review content helpfulness ratings findings demonstrate importance examining discrete emotions online word mouth carry important practical implications consumers online retailers
paper explores proposal close link counterfactual thinking lying require imagination alternatives reality describe four studies explore link study measured individual differences abilities found individuals tendency generate counterfactual thoughts also likely generate potential lies studies showed counterfactual availability influences people ability come lies extent expect others lie study used behaviotiral measure deception show people tend lie situations also known elicit counterfactual thoughts overall results show imagination alternatives past plays important role generation lies discuss implications fields counterfactual thinking deception elsevier rights reserved
paper focuses robust state feedback controller design strategy single phase inverter output lowpass filter state space representation single phase converter presented assuming load exsanguinous disturbance input modeled current source parallel uncertain linear load according norm bounded linear differential inclusion nldi notation robust stability linear matrix inequalities lmi techniques sufficient conditions gathered design robust state feedback furthermore based internal model principle steady state error removed adding resonant controller simulation results linear nonlinear load presented
paper focuses effectiveness passive adaptation measures climate change medium long term three case studies located florence central italy order identify highlight passive measures provide comfort conditions lowest net heating cooling energy demand input assumptions consider constant thermal comfort level take account either effect hvac system performance degradation materials ageing study results show case poorly insulated buildings medium term reduction energy needed heating could bigger increase cooling resulting total annual net energy need decrease long term opposite happens conversely considering high level thermal insulation due large increase cooling demand total annual energy need rises periods furthermore attention paid internal loads solar gains due projected climate change could become main contributors energy balance general since magnitude energy need increase cooling decrease heating significant long term varies function type building passive measure adopted level thermal insulation research results lead pay close attention different types energy refurbishment interventions selected function effectiveness time
paper focuses develop cognitive architecture demonstrates broad range cognitive issues decision making learning problem solving planning using concepts swarm intelligence investigate behavior swarm intelligent agents ambient environment respect motivation coordination performance check performance agents group varies proper motivation coordination since group agents performing together intelligence performance exhibiting group always greater individual intelligence performance question exactly happening groups performance superior individuals better group members performance group better makes individual member better research work provides solution stated problem developing cognitive architecture found actual dependents type individuals group type task performed agents
paper generalizes well known diffusion curves images dci composed set bezier curves colors specified either side colors diffused laplace functions image domain results smooth color gradients interrupted bezier curves new formulation allows color control away boundary providing similar expressive power recent bilaplace image models without introducing associated issues computational costs new model based special laplace function blending new edge blur formulation demonstrate given user defined boundary curves input raster image fitting colors edge blur image new model subsequent editing animation equally convenient dcis numerous examples comparisons dcis presented
paper gives brief survey several ideas literature increase student enthusiasm engagement learning incorporating multimedia production assignments description given ideas adopted scenario control engineering bioengineers evidence student work student reflections efficacy approach indeed excellent student feedback provided ifac international federation automatic control hosting elsevier ltd rights reserved
paper handles proposed anti stealth technique countering radar absorbent material stealth technology enhancing material electric permittivity wave absorber used experimental work optical properties exhibit stealth characteristics absorption coefficient reflection coefficient wavelength frequency mhz enhancing electric permittivity decreasing loss tangent performed using non lethal yag impedance analyzer agilent test results shows increasing electric permittivity percentage frequency band mhz ghz also decreasing loss tangent mhz ghz research problem implementing anti stealth technique invisible dynamic environment structure offensive target uncertain considerations making unmanned aerial vehicle defensive covering surface certain number laser beam firing angle according dimensions laser beams create symmetric geometries transverse aircraft expected dimensions offensive stealth target accuracy system determined mathematical modeling laser beam firing angle model predictive control fuzzy logic control used controlling laser beam firing angle covering unmanned aerial vehicle surface achieving intelligent geometry uncertain target structure target permittivity increased electromagnetic waves detect target destroying using pulsed laser beam monograph future research enhancing anti stealth implementation
paper identifies number key elements underpinned success australia public health response minimizing spread hiv argued one major factor high level collaboration health care professionals affected communities injecting drug users sex industry workers gay men collaboration allowed negotiation development implementation range innovative hiv initiatives ultimately responsible keeping hiv injecting drug use sex industry low levels despite central role played injecting drug users peer based organizations significance activities gone largely unacknowledged senior health bureaucrats politicians consequence advice injecting drug users peer based organizations current hepatitis epidemic largely ignored instead learning australia hiv experience involving groups consultation advisory roles federal government reverted accepting advice established mainstream organizations argued success infection control outside mainstream communities among injecting drug users effectively achieved involvement affected communities need local national international levels ensure involvement affected communities recognition given significant essential role play infection control
paper identifies management practices green building management malaysia set practices ascertained reviewed various established green building standard world green building practices significant role attaining sustainability particularly construction industry green building constructed minimizing impacts environment well decreasing building effects occupants achieve goals green buildings set management practices required comprehensive review world green building standards include criteria management carried results content analysis identified total five clusters practices found important effective management green building malaysia including sustainable procurement sustainable operation resource management repair maintenance management environmental health cluster management practice composed activities identification set practices contributes effective efficient operation green building advancing sustainability agenda hence decreasing building operating costs realising increase return investment
paper introduced improvement original control system process control laboratory development liquid level temperature flow time sharing control experiment platform adopting profibus fieldbus technology siemens newly designed control system using plc master control unit slave control unit touch screen upper computer able achieve real time monitoring spot operation adjust control parameters centralized management provide convenience experimenters practical operating results show platform extends function equipment improves utilization rate equipment also help students understand master advanced control technologies technology application plc touch screen process control engineering research control algorithms
paper introduces cmos vision sensor chip standard cmos technology gaussian pyramid extraction gaussian pyramid provides computer vision algorithms scale invariance permits response regardless distance scene camera chip comprises photosensors arranged processing elements pes gaussian pyramid generated double euler switched capacitor network every comprises four photodiodes one single slope analog digital converter one correlated double sampling circuit four state capacitors corresponding switches implement double euler network every occupies measurements chip presented assess accuracy generated gaussian pyramid visual tracking applications error levels full scale output thus making chip feasible applications also energy cost mpx thus outperforming conventional solutions imager plus microprocessor unit
paper introduces design fabrication pipeline creating floating forms method optimizes buoyant equilibrium stability complex shapes applying voxel carving technique control mass distribution resulting objects achieve desired floating pose defined user specified waterline height orientation order enlarge feasible design space explore novel ways load interior design using prefabricated components casting techniques printing employed high precision fabrication larger scale designs introduce method stacking lasercut planar pieces create objects quick economic manner demonstrate fabricated designs complex shape variety floating poses
paper introduces model based environment application parallel signal processing domain key concepts approach domain specific model based programming environment automatic software synthesis technique enabling non software engineers build complex applications graphical model building multiple aspects hierarchy multiple views help manage complexity application configurable model builder unified run time support make use core technology different domains possible parallel signal processing domain signal flow graph hardware topology resources assignment constraints modelled macro dataflow graph generated signal flow model partitioned mapped onto processor network satisfying assignment constraints required makefiles message routing maps network loader configuration files also automatically generated different system engineering tools provide hardware topology verification performance prediction based information extracted models
paper introduces module integrated distributed battery energy storage management system without need additional battery equalizers centralized converter interface achieved integrating power electronics onto battery cells integrated module compared conventional centralized battery system modular design brings several advantages reduced power rating voltage stress power electronics extra equalizers centralized converters active thermal distribution control ability enhanced safety reliability etc battery system built simply attaching integrated modules together integrated module implemented synchronous bidirectional converter digital control techniques design considerations control strategy system discussed prototype built power electronics integrated onto battery cell experimental results three module system verified module integrated distributed system provides satisfied functional performance without extra equalizers centralized charger bidirectional converter
paper introduces new current mode component called modified current differencing transconductance amplifier mcdta important parameters circuit input resistance terminal resistance transconductance output stage tuned electrically circuit implemented linear non linear analog signal processing paper presents example mcdta application complete quadrature oscillator amplitude regulation functionality example circuit tuning capability proved spice simulation results
paper introduces new version particle swarm optimization pso method two basic modifications conventional pso algorithm proposed improve performance algorithm first modification inserts adaptive accelerator parameters original velocity update formula pso speeds convergence rate algorithm ability algorithm escaping local optima improved using second modification case particles swarm named superseding particles selected mutated probability proposed modified pso mpso simple implemented fast reliable validate efficiency applicability mpso applied designing optimal fractional order pid fopid controllers benchmark transfer functions introduced mpso applied tuning parameters fopid controllers five bar linkage robot sensitivity analysis fractional order pid controller also provided numerical simulations reveal mpso optimally tune parameters fopid controllers
paper introduces nonlinear certainty equivalent approximation method dynamic stochastic problems first introduce novel stable efficient method computing decision rules deterministic dynamic economic problems use results nonlinear global certainty equivalent approximations solutions stochastic problems compare accuracy common linear local certainty equivalent methods examples demonstrate method applied solve high dimensional problems state variables acceptable accuracy method also applied solve problems inequality constraints features make nonlinear certainty equivalent approximation method suitable solving complex economic problems algorithms log linearization fail produce valid global approximation far less tractable
paper introduces nonlinear control scheme based linearized state space representation nonlinear permanent magnet synchronous motor pmsm model predictive concept control pmsm comprehensive detailed description design process generalized predictive control gpc design implementation hildreth quadratic programming permanent magnet synchronous motor given finally simulation results show application superiorities potential generalized predictive control scheme multi variable system classical anti windup method case constraint condition
paper introduces novel backward forward sweep algorithm fundamental harmonics flow calculation distribution network algorithm fundamental harmonic currents branch calculated equivalent current injection method relationship branch currents harmonic currents order radial feeder calculated summing injection current receiving end toward sending end feeder obtaining branch currents harmonics bus voltage fundamental bus voltage easily obtained sending end receiving end based kirchhoff voltage law using method decomposition avoided save huge computational time base special hierarchy characteristic radial network branches sorted layers branch power loss voltage drop computed parallel level computational time reduced test results demonstrate flexible accuracy efficiency proposed method
paper introduces parallel distributed algorithm solving following minimization problem linear constraints minimize subject element chi element chi convex functions matrices feasible sets variable algorithm extends alternating direction method multipliers admm decomposes original problem smaller subproblems solves parallel iteration paper shows classic admm extended block jacobi fashion preserve convergence following two cases matrices mutually near orthogonal full column rank proximal terms added subproblems without assumption matrices latter case certain proximal terms let subproblem solved flexible efficient ways show converges rate symmetric positive semi definte matrix since parameters used convergence analysis conservative introduce strategy automatically tuning parameters substantially accelerate algorithm practice implemented algorithm case amazon tested basis pursuit problems distributed data first time successfully solving compressive sensing problem large scale reported
paper introduces pictorial intelligent system human identification pishi image based captcha uses three human cognitive abilities distinguish humans machines first human ability easily recognise image upright orientation second human brain ability recognising picture content partially visible third human ability unconscious decision making encountering pictorial challenges work models complicated human patterns problem solving first time order extract behavioural patterns save pattern database implemented captcha performed series experiments pishi interface presents user set distorted pictures asks click upright orientation pictures preferred order next captures user interaction patterns compares ones saved pattern database grants corresponding credit based credit user either passes fails test participates updating picture database experiments indicate human users solve proposed captcha effectively accuracy besides proposed system secure several types attacks including random guessing reverse image search engines results offer possibility utilising identified human behavioural models practical captchas
paper investigated field monitoring suspension bridge assessment load test using integrated distributed fibre optic sensors dfoss addition conventional brillouin time domain analysis system high spatial resolution brillouin system using differential pulse width pair dpp technique adopted temperature compensation achieved using raman distributed temperature sensing system first full scale field application dfoss using brillouin time domain analysis technique thousand meter scale suspension bridge measured strain distributions along whole length bridge presented interaction main cables steel box girder highlighted brillouin fibre optic monitoring systems exhibited great facility purposes long distance distributed strain monitoring spatial resolution point sampling interval performance brillouin system using dpp technique discussed measured data also employed assessing bridge design assessment structural condition results show symmetrical design assumptions consistent actual bridge strain values along whole bridge within safety range trial field study serves example demonstrating feasibility highly dense strain temperature measurement large scale civil infrastructures using integrated dfoss
paper investigates dynamic relationship japanese yen exchange rates market anxiety period january april quantitative technique multifractal detrended cross correlation analysis dcca used explore multifractal features cross correlations usd jpy aud jpy exchange rates market anxiety gauge vix investigation shows causal relationship japanese yen exchange rates vix bidirectional general cross correlations two sets time series multifractal strong evidence suggests cross correlation exponents tend exhibit different volatility patterns response diverse external shocks financial distress widening interest rate spread suggesting cross correlated behavior japanese yen exchange rates vix susceptible economic uncertainties risks addition performances two market anxiety gauges vix ted spread compared sources multifractality also traced thus paper contributes literature shedding light unique driving forces yen exchange rate fluctuations international foreign exchange market elsevier rights reserved
paper investigates effect two soft magnetic materials high speed machine design namely silicon steel cobalt iron alloy effect design parameters machine performance aircraft starter generator analyzed material properties include characteristics losses obtained different frequencies experiment used predict machine performance accurately investigation presented paper shown machines designed silicon steel high core flux density lower weight lower losses cobaltiron alloy designs mainly due extra weight contributed copper content especially end windings due high operating frequencies core losses cobalt iron machine designs found outweigh copper losses incurred silicon steel machines also shown change stack length number turns considerable effect copper losses starting however significant advantage rated efficiency happens field weakening operating point also shown performance machine designs depends significantly material selection operating point core implications variation design parameters machine performance discussed provide insight influence parameters effect overall power density
paper investigates impact plug electric vehicle integration power systems scheduling energy cost intermediary entity aggregator participates market behalf owners optimally self scheduling price taking approach detailed rolling simulations year different evs penetration scenarios large insular power system work highlights different impact direct smart charging power system scheduling energy costs limitations price taking approach widely used self scheduling models difference system value market value smart charging adoption creates restructured markets marginal pricing rule
paper investigates influence switching frequency modulation index combined welding iron losses thin silicon iron nickel iron lamination sheets small slotless permanent magnet synchronous machine pmsm first measurements conducted welded nonwelded stator ring cores switching frequencies khz modulation indexes keeping constant fundamental flux density peak values possible changing link voltage inverter obtained measurement data afterward used finite element method simulations investigate inverter influence performance pmsm
paper investigates market potential environmental benefits replacing internal combustion engine ice vehicles battery electric vehicles bevs taxi fleet nanjing china vehicle trajectory data collected onboard global positioning system gps units used study travel patterns taxis impacts charger power charging infrastructure coverage taxi apps feasibility electric taxis quantified considering taxi drivers recharging behavior operating activities found depending charger power coverage level chargers charger network coverage chargers charger network coverage ice vehicles replaced electric taxis without driving pattern changes using taxi apps find nearby passengers charging stations drivers could utilize empty cruising time charge battery may increase acceptance bevs compared scenario without taxi apps tailpipe emissions urban areas could significantly reduced taxi electrification mixed taxi fleet compressed natural gas powered cng electricity powered vehicles reduce tailpipe emissions comparison fleet cng taxis elsevier ltd rights reserved
paper investigates robust simultaneous stabilization rss robust adaptive simultaneous stabilization rass problem set port controlled hamiltonian pch systems results designing family robust simultaneous controllers tuning parameters systems proposed firstly using dissipative hamiltonian structural properties systems combined generate augmented pch system two simultaneous stabilization controllers parameters designed systems one robust controller adaptive secondly algorithm solving tuning parameters ranges controller proposed symbolic computation finally numerical example studied applying method obtained paper set pch systems external disturbance effectiveness proposed control method verified simulations compared conventional simultaneous stabilization control controller obtained paper strong robustness set systems also optimize robustness systems adjusting parameters values
paper investigates state feedback based output regulation boolean control networks bcns via semitensor product matrices based algebraic state space representation bcns necessary sufficient condition presented solvability state feedback based output regulation problem study illustrative example shows obtained new results effective analyzing output regulation bcns
paper concerned suspension bridge equation memory effects defined bounded domain suspension bridge equation without memory many classical results existing results mainly devoted existence uniqueness weak solution energy decay solution existence global attractors however existence global attractors suspension bridge equation memory yet considered object present paper provide results well posedness long time behavior suspension bridge equation past history copyright john wiley sons ltd
paper dedicated acceptance rate various forms electronic communication perspective specific segment students communicating internet theoretical part deals definitions communication consists verbal nonverbal communication well various forms electronic communication interactive non interactive combined communication main part paper includes implementation quantitative marketing research gather information frequency communication internet preferences various forms electronic communication form student point view conclusions determine degree acceptance various forms electronic communication used specific segment students
paper focused performance optimization applications based non relational databases firstly explained differences relational non relational databases also compared types non relational databases advantages disadvantages mongodb elasticsearch sql database systems described compared database systems implemented web server speed compared order determine system better use different conditions tasks
paper part study blood flow across cardiovascular stenoses part developed rigorous mathematical approach deriving pressure field experimental data velocity field obtained direct measurement part existing methods quantifying stenoses specific reference cardiac valves reviewed using mathematically rigorous physically reasonable approach developed part pre specified flow velocity field proximal stenosis pressure waveform field distal stenosis ascertain intra stenosis distal flow velocity field pressure field proximal within stenosis energy dissipation functions position time computed dissipation kinetic energy pressure presented idealized geometry relevant realistic geometry symmetric stenosis elsevier ltd rights reserved
paper present virtual instrumentation system learning operational amplifiers amps circuits function design analysis combining schematic diagram simulation tools multifunction data acquisition board daq measurement features provided labview real analog signals easily sampled compared signals simulated amp circuits proposed system studied amp circuits different configurations inverting adder integrator amplifier minimal modifications added circuits configurations inverting subtraction differential nonlinear circuits simulated amp circuits models based electrical characteristics components experimental platform consists integrated circuit amp related components configured diagram power supply voltage signals applied input circuit come external source signal generator generated using daq module generated signals daq module form voltage sinusoidal triangular rectangular signals parameters easily adjusted software parameter values measured using daq module specially designed virtual instruments output signal values daq module may manually applied point point input circuit test applied automatically
paper presents turn fluorescence biosensor based graphene quantum dots gqds molybdenum disulfide mos nanosheets rapid sensitive detection epithelial cell adhesion molecule epcam pegylated gqds used donor molecules could largely increase emission intensity also prevent non specific adsorption pegylated gqd mos surface sensing platform realized adsorption pegylated gqd labelled epcam aptamer onto mos surface via van der waals force fluorescence signal gqd quenched mos nanosheets via fluorescence resonance energy transfer fret mechanism presence epcam protein stronger specific affinity interaction aptamer epcam protein could detach gqd labelled epcam aptamer mos nanosheets leading restoration fluorescence intensity monitoring change fluorescence signal target epcam protein could detected sensitively selectively linear detection range limit detection lod around addition nanobiosensor successfully used epcam expressed breast cancer mcf cell detection elsevier rights reserved
paper presents case history geotextile reinforced dry cover placement reclaimed clay deposit treated progressive trenching method order investigate effects cover material characteristic ensuring trafficability respect bearing failure ground deformation two types covers considered pilot tests layer weathered granite soil cover layer weathered granite soil stiff crushed stone number situ plate load tests conducted various cover conditions assess bearing capacity reclaimed deposit determine thickness material compositions satisfy bearing capacity requirement full scale pilot tests cover placement field monitoring carried surface settlement pore pressure developed reclaimed clay layer results plate loading tests monitoring staged cover placements discussed compared using numerical predictions obtained finite element analyses undrained stability analyses comparison results showed drainage condition ground surface facing dry cover strongly related ground response stability
paper presents case study analyzing advantages disadvantages using project based learning pbl combined collaborative learning industry best practices integrated information communication technologies open source software open source hardware tools specialized microcontroller embedded systems engineering master course addition addressing industry requirements contents methodology course develops capabilities competencies problem solving independent learning teamwork technical knowledge since pbl methodology alone ensure teamwork complemented design review meetings described iec deliverables organizational resources also introduced mirror industry demands structure integrated course content student academic achievement simulated industrial environment course students build modular management system home appliances implementing control software arduino open source platform well using wireless communications results show teaching learning student assessment processes improved using pbl addition introduction industry practices peer review meetings brings academia closer real world context
paper presents case study describe features phases two agent methodologies gaia methodology agent oriented analysis design tropos detailed agent oriented software engineering methodology explore methodology ability present solutions small problems also provide attempt discover whether methodology fact understandable usable addition collecting taking notes advantages weaknesses methodologies study analysis methodology relationships among models guardian angle patient centered health information system pchis personal system help track manage interpret subject health history give advice patient provider used case study throughout paper
paper presents comparison among mathematical models used simulation solar photovoltaic modules easily integrated power electronic converters order perform analysis three models available literature also physical model module software psim used results regarding respective ixv pxv curves presented advantages eventual limitations discussed besides buck converter performs maximum power point tracking using perturb observe method performance one aforementioned models investigated
paper presents comprehensive low voltage residential load model price based demand response high resolution load models developed combing monte carlo markov chain bottom demand models hot water demand models discrete state space representation thermal appliances composite time variant electrical load models price based modeled control algorithms thermostatically controlled loads optimal scheduling wet appliances price elasticity matrices representing inherent elastic response consumer developed model used case study examine potential distribution network impacts introduction dynamic pricing schemes effects cold load pick rebound peaks decrease electrical demand diversity impacts loading voltage presented
paper presents computational platform dynamic security assessment dsa large electricity grids developed part itesla project leverages high performance computing analyze large power systems many scenarios possible contingencies thus paving way pan european operational stability analysis results dsa summarized decision trees stability indicators platform workflow parallel implementation architecture described detail including way commercial tools integrated plug architecture case study french grid presented scenarios contingencies performance data case study using parallel cores analyzed including task timings data flows finally generated decision trees compared test data quantify functional performance dsa platform
paper presents computer vision based algorithm automatically detects components interior partition infers current state using digital images algorithm relies four integrated shape color based modules detect studs insulation electrical outlets three states drywall sheets installed plastered painted based results four modules images classified five states proposed method validated using three image databases indoor construction sites captured quadcopter type unmanned aerial vehicle smartphone collected publically available sources internet method high accuracy rates fast performance applicability different contexts automated robotic inspection indicative promising performance visual detection results potentially provide situational awareness construction trades provide future progress tracking systems information actual state help leverage use image processing indoor sites elsevier rights reserved
paper presents coordinated model predictive control scheme mid columbia hydropower system mid columbia system consists seven hydropower plants columbia river united states state space model used control scheme accounts system hydraulics modeling time delayed hydraulic coupling dynamic tailrace elevations approximate power generation hydropower plant using piecewise planar function turbine discharge hydraulic head demonstrate approximation written set linear constraints integrated quadratic program introduce flow minimizing objective function maximizes system hydraulic potential efficiently allocating water compared historical operations proposed control scheme reduces ramping increases total system hydraulic head increases system energy content operates system within elevation flow constraints
paper presents current driver integrated angular acceleration sensor readout circuit architecture proposed amplifier consists voltage follower inverting amplifier achieve differential output amplifier follower based three stage class operational amplifier power output stage output current current driver controlled input voltage maximum value proposed circuit designed cmos technology typical output current flow equivalent sensor load ohm rna rise time
paper presents cyber physical management smart buildings based smart gateway network distributed real time energy data collection analytics consider building multiple rooms supplied one main electricity grid one additional solar energy grid based smart gateway network energy signatures rooms first extracted consideration uncertainty classified different types agents multiagent minority game based demand response management introduced reduce peak demand main electricity grid also fairly allocate solar energy additional grid experiment results show compared traditional static centralized energy management system ems recent multiagent ems using price demand competition proposed uncertainty aware ems achieve utilization rate improvements respectively regarding fairness solar energy resource allocation importantly peak load main electricity grid reduced summer winter based benchmarked energy data building lastly average uncertainty reduced according balanced energy allocation improved comparing ems without consideration uncertainty
paper presents decentralized control method distributed generations dgs islanded direct current microgrid typical microgrids decentralized control method based voltage droop control method however grid voltage differs node node due line voltage drop hence power sharing ratio among dgs matched desired value especially islanded microgrid including energy storage system voltage source difficult dgs maintain charge state ess decentralized way overcome problem state charge soc voltage droop control applied ess using proposed droop method soc information assigned grid voltage hence dgs able support soc decentralized way dgs enhance accuracy soc estimation voltage drop compensated based forecasting data line impedance data simulation modeled implemented using power system computer aided design electromagnetic transients pscad emtdc version winnipeg manitoba canada simulation results show capability maintain soc well system voltage profile improved using proposed method
paper presents demodulation algorithm based synchronous integrator circuit mems tuning fork gyroscope utilizing digital processing technology synchronous integral demodulator sid adopted demodulate drive detection signal sense axis output signal separately combining automatic gain control phase locked loop technology closed loop control drive mode implemented high precision output gyroscope achieved simulation results verified effectiveness synchronous integrator circuit good agreement theoretical analysis compared demodulation algorithms sid advantages lower noise level better ability attenuate harmonics best hardware efficiency frequency characteristic synchronous integrator also analyzed vital bandwidth gyroscope print circuit board based field programmable gate array digital circuit manufactured corresponding experiment carried experimental results show sid algorithm digital control system gyroscope developed laboratory achieved good performance bias instability tested gyroscope measured degrees angle random walk degrees root nonlinearity scale factor ppm measurement range degrees
paper presents design assistance methodology low speed switched reluctance machines srm using field based models magnetic properties iron number rotor poles number poles per phase play significant role machine design proposed comparison procedure uses field based models along scale models based similarity laws compare srm designs field based models applied dimensional analysis regular non regular topologies distinguished different characteristics electric magnetic circuits added value methodology similarity laws take account physical phenomena like thermal changes magnetic saturation hypotheses introduced methodology formulation verified finite element analysis work motivated application srm direct drive wind converters low speed renewable energy systems application example methodology non regular topology short flux paths compared regular prototype phase srm designed direct drive wind turbine gain power per unit mass achieved former one
paper presents digital active gate drive agd methodology power semiconductor devices inherent latency limitation digital signal processing systems addressed sequential optimization procedure uses voltage current signals recorded previous switching edge develop optimized gate drive waveform next switching edge experimental results using half bridge circuit operating show proposed scheme capable minimizing switching losses whilst constraining overvoltage peaks occurring turn turn low respectively
paper presents digital motion controller electric wheelchair using low cost real time microcontroller unit mcu developed power electronic drive speed control wheels implemented digital pulse width modulation technique varying reference generated low cost joystick voltage regulators power converters implemented supply correct voltage levels control cards motors batteries experimental results obtained using mcu mechanical structure used electric wheelchair developed electronic drive demonstrate proposed digital controller meets user requirements terms reliability good driving fair economic cost
paper presents digital testing strategy characterizing analog circuit block operational amplifier amp evaluated due wide application electronic circuits systems proposed strategy amp device test dut configured respond testing pulse associated output digitized digital buffer reduce high cost generating high frequency clock testing procedure divided two modes estimate reference slew rate evaluate practical slew rate moderate difficulty designing digital buffer highly precise delay time testing concept accuracy time hardware also comprehensively investigated describe proposed testing strategy digital compatibility simplicity testing capability high performance amp main advantages proposed testing strategy easily available discrete devices experimentally employed verify functionality proposed testing strategy integrated application test amp dut embedded second order sallen key low pass filter simulated hspice tool verify testing feasibility effectiveness proposed strategy
paper presents feedback gui improve motor skills subject performing golf putt paper inertial sensors gyroscopes video used capture swing feedback provided graphical user interface created matlab displayed video putt quantitative values putt tempo ratio backswing duration downswing duration score gives indication close putt tempo ideal rato zero crossing method used determine swing phases durations rotational velocity effectiveness feedback gui tested using participants experienced inexperienced participant executed two sets putts distances artificial turf putting surface feedback provided gui two sets putts results indicated overall tempo ratio experienced inexperienced participants became closer feedback standard deviation also decreased meant participants also improved putting consistency results indicate participants able improve skill terms putting performance indicators using feedback gui authors published elsevier ltd selection peer review responsibility school aerospace mechanical manufacturing engineering rmit university
paper presents first order scaling friendly vco based closed loop delta sigma adc uses vco quantizer integrator thus obviates need power hungry scaling unfriendly otas precision comparators arranges two vcos differential manner cancels even order distortions importantly inherit mismatch shaping capability automatically addresses dac mismatches prototype delta sigma adc cmos occupies small area achieves sndr mhz sampling mhz consuming power supply also operate low analog supply achieves sndr consuming
paper presents formal method designing cryptographic processor datapaths basis arithmetic circuits galois fields gfs proposed method describes arithmetic circuits form hierarchical graph structures nodes represent sub circuits whose functions defined arithmetic formulae gfs edges represent data dependency nodes paper first introduce application graph representation arithmetic circuits extension fields composite fields commonly used design cryptographic processors newly proposed graph representation formally verified symbolic computation techniques based polynomial reduction grobner basis demonstrate capabilities proposed approach experimental design bit aes advanced encryption standard datapath including multiplicative inversion circuits composite field results show proposed method describe practical datapaths well complete verification datapath carried within short period time
paper presents formal model decision making system public transport routes approach focuses environmental societal sustainability aspects green software engineering spatial planning optimisation smarter sustainable cities user satisfaction information system various contexts passenger driver overall system view
paper presents four quadrant analog multiplier using dual second generation current conveyors dxcciis proposed multiplier employs two dxcciis eight mos transistors operating saturation region ideal monolithic implementation use mos devices operating saturation region offers high frequency capability circuit pspice simulators using tsmc cmos process used validate workability circuit simulation results show circuit bandwidth mhz total harmonic distortion input current
paper presents framework structural health monitoring shm damage identification civil structures framework integrates advanced mechanics based nonlinear finite element modeling analysis techniques batch bayesian estimation approach estimate time invariant model parameters used model structure interest framework uses input excitation dynamic response structure updates nonlinear model structure minimize discrepancies predicted measured response time histories updated model interrogated detect localize classify quantify state damage predict remaining useful life structure opposed recursive estimation methods batch bayesian estimation approach entire time history input excitation output response structure used batch data estimate model parameters number iterations case non informative prior batch bayesian method leads extended maximum likelihood estimation method estimate jointly time invariant model parameters measurement noise amplitude extended estimation problem solved efficiently using gradient based interior point optimization algorithm gradient based optimization algorithms require response sensitivities respect model parameters identified response sensitivities computed accurately efficiently using direct differentiation method ddm estimation uncertainties evaluated based cramer rao lower bound crlb theorem computing exact fisher information matrix using response sensitivities respect model parameters accuracy proposed uncertainty quantification approach verified using sampling approach based unscented transformation two validation studies based realistic structural models bridge pier moment resisting steel frame performed validate performance accuracy presented nonlinear model updating approach demonstrate application shm validation studies show excellent performance proposed framework shm damage identification even presence high measurement noise way initial estimates model parameters furthermore detrimental effects input measurement noise performance proposed framework illustrated quantified one validation studies elsevier ltd rights reserved
paper presents generic functional design modelling methodology applied computer aided design cad environment associate functional considerations physical models design function concept modelling represents engineering design purposes product elements usually considered interdependent detailed geometric solutions although cad prevailing modelling geometry design artefacts functional considerations design intents often represented systematically explicitly gaps functional geometrical representations design models require extensive research unveil associations interactions functional feature corresponding semantic representation built mechanisms proposed paper support cad methodology models interrelations functional physical considerations design drives design functional perspective abstract geometry features used functional concept carriers certain geometries link functional design considerations detailed design model case study designed product used oil extraction process oil sands canada presented demonstrate feasibility proposed methodology
paper presents handheld robust battery operated contact based ovality meter suitable measurement ovality pipeline plant site industrial establishment ovality meter mainly composed specially designed inductor ferrite core inductor constitutes part type logic gate oscillator lgo change sensor position measurement pipe diameter causes small change inductance turn changes pulse frequency lgo powered thus frequency output instrument displayed liquid crystal display embedded processor function displacement measuring diameter pipe specimen different locations ovality computed present design range position measurement sensitivity position measurement similar reduces higher range sensitivity position measurement seems quite suitable ovality measurement
paper presents knowledge based intelligent decision system kids takes information vision sensor within manufacturing process generates automatic planning path planning decisions collision avoidance virtual cam production paper integration kids approach presented context conventional multi axis machining proposed system would implemented conventional machining processes paper future implementation context step based cam systems also discussed contribution provides secure solutions detect avoid collisions using multiple solutions including tool diversion strategy also offers many opportunities process change sequence change plan change etc turret machining scenario used test case two tools working together possess synchronization issue multi tool synchronization cycles preparation take account management materials left work part proposed solutions allow multiple opportunities machining units blank groove enriched new associated data uncut material identified visually may cause collisions production limited however therefore could integrated step cam simulation environment system gaining acceptance industry
paper presents low power compact low complexity pulse width modulation based interface circuit capacitive mems sensors circuit designed using ring oscillator controlled pulse generator high pass filter self tuning inverter comparator produce pulse width proportional differential capacitance independent parasitic capacitance high pass filter utilized reduce bandwidth noise sources circuit provides control sensitivity dynamic range nominal point capacitance measurement selecting controlling parameters resistance pulse generator biasing voltage self tuning inverter comparator reference capacitor using digital control signals circuit provides high linearity higher sensitivity lower power consumption sensitivity circuit depending controlling parameters maximum dynamic sensing range depending controlling parameters interface circuit designed fabricated using united microelectronics corporation umc cmos technology occupies active area consumes capacitive mems based pressure sensor also connected interface circuit measure pressure throughout digestive tract sensitivity pressure kpa kpa kpa kpa
paper presents low power high slew rate high gain ultra wide band two stage cmos cascode operational amplifier radio frequency application current mirror based cascoding technique pole zero cancelation technique used ameliorate gain enhance unity gain bandwidth respectively novelty circuit cascading technique common source transistor drive common gate transistor cascoding used enhance output resistance hence improve overall gain operational amplifier less complexity less power dissipation bias common gate transistor current mirror used paper proposed circuit designed simulated using cadence analog digital system design tools nanometer cmos technology simulated results circuit show gain unity gain bandwidth ghz slew rate phase margin degrees power supply proposed operational amplifier rail rail power consumption circuit specification encountered requirements radio frequency application
paper presents low voltage continuous time delta sigma modulator dsm intended receiver ultra low power radio dsm features order loop filter implemented single operational amplifier reduce power consumption furthermore bit quantizer used achieve high resolution keeping sampling frequency low quantizer realized using successive approximation register architecture asynchronous control power efficient commonly used flash architecture dsm implemented cmos process simulation results show peak sndr khz signal bandwidth dsm consumes power supply
paper presents low cost solution evaluation frequency domain phase noise characteristics analog signals technique based bit signal acquisition standard digital channel automated test equipment ate dedicated post processing algorithm permits reconstruct time domain phase fluctuations analog signal captured binary vector single sideband ssb phase noise obtained based fft applied reconstructed phase fluctuations simulation results demonstrate good agreement ssb phase noise obtained using proposed digital method conventional analog method large range measurement frequency offset digital method also permits spur detection exhibits similar performance conventional method terms measurement variability technique also validated hardware measurements practical case study ssb phase noise evaluation mhz sinusoidal signal delivered transceiver wireless microcontroller
paper presents manufacturing execution system factory developed integrate manufacturing engineering procurement production planning manufacturing quality functions factory system supports production preparation process main input process data related three dimensions production product data project parameters plant data outputs production preparation authors published elsevier selection peer review responsibility professor mourtzis professor chryssolouris
paper presents mathematical programming model optimal design water networks agriculture proposed model based new superstructure includes configurations terms use reuse regeneration water field constituted number croplands model also includes allocation pipelines pumps storage tanks different irrigation periods objective function consists maximizing annual profit formed economic incomes owing crop sell minus costs fresh water fertilizer storage tanks treatment units piping pumping proposed multi period optimization problem formulated mixed integer non linear programming formulation applied case study demonstrate economic environmental social benefits obtained elsevier ltd rights reserved
paper presents monitor assistant system detection dangerous events health diagnostics patients dementia proposed framework brings together three different types ambient intelligence sensors detecting life threatening events occur home like falls anomalies vital signs predicting risk myocardial infarction sensors placed bed posts detecting unhealthy poor movement patients lying bed cause bedsores decubitus iii analysis current cognitive state patients dementia means serious computer games paper presents framework methods sensors used system assist patients dementia triggering different type alarm signals informing patient needs help could provided
paper presents new compact two stage cmos structure enhanced gain bandwidth product gbw high slew rate frequency compensation technique employed comprises negative capacitance cell flipped voltage follower fvf use negative capacitance lowers parasitic capacitance preceding stage thereby achieves significant improvement gbw fvf acts voltage buffer exploits pole zero cancellation technique required compensation capacitor small save chip area workability proposed circuit verified using mentor graphics eldo simulation tool tsmc cmos process parameters simulated results show gbw ghz average slew rate power consumption
paper presents new approach network traffic control based pattern theorem order generate unique detection patterns process traffic analysis self avoiding walk algorithm used data processing analysis traffic patterns adapted dynamically real time modified traffic patterns systematically analyzed using threat database work threshold set distinguish trigger critical levels threats matching process terminated three conditions pattern matching rate pattern matching rates least five various threats iii pattern matching enhanced matched pattern using implicit combination threat coefficients experimental results show worst case scenario true detection rate malicious traffic higher best situation would malicious traffic also precision false detection trusted patterns negligible copyright john wiley sons ltd
paper presents new circuit realization capable simultaneously realizing three current mode first order filtering functions namely low pass high pass pass proposed circuit created using three programmable current amplifiers pcas two passive components includes one resistor one capacitor filters independently tuneable gain pole frequency means factors filter tunable gains pole frequency ideally controllable external passive components theoretical results verified spice simulations using transistor model process parameters nrn npn prn pnp bipolar arrays ala cbic
paper presents new content based synthetic aperture radar sar image retrieval method search sar image patches consists two essential parts initial retrieval later refined results obtain proper initial retrievals develop similarity measure named region based fuzzy matching rfm evaluate similarities sar image patches first reduce negative influence speckle noise segment sar image patches brightness texture regions superpixel level rather pixel level second multiscale edge detector utilized resolve multiscale property sar image patches edge regions sar image patches defined edge features third overcome segmented uncertainty blurry boundaries obtained regions described fuzzy features finally rfm similarity two sar image patches converted linear summation resemblance different fuzzy feature sets obtain initial retrieval results multiple relevance feedback mrf scheme proposed refine original ranked list scheme different relevance feedback approaches carried respectively results fused improve initial retrieval addition new kernel function based rfm measure developed mrf encouraging experimental results counted manually constructed ground truth sar image patch dataset demonstrate retrieval method effective sar images compared existing approaches proposed remote sensing community
paper presents new control strategy based switching table applied virtual flux direct power control dpc voltage source inverter based shunt active power filter sapf control method applied eliminate harmonic pollution compensate reactive power presence nonlinear loads unbalanced sources main goal select switching states sapf converter appropriately based look table established hysteresis controllers acting instantaneous error commanded estimated values active reactive power method aims improve electrical quantity behavior steady dynamic states reducing installing cost filter eliminating line voltage sensors facing disturbances affecting electrical network phase locked loop pll integrated control strategy proposed active filter tested matlab simulink environment
paper presents new encryption scheme implemented physical layer wireless networks employing orthogonal frequency division multiplexing ofdm new scheme obfuscates subcarriers randomly reserving several subcarriers dummy data resequences training symbol new secure sequence subcarrier obfuscation renders ofdm transmission secure random whereas training symbol resequencing protects entire physical layer packet affect normal functions synchronization channel estimation legitimate users preventing eavesdroppers performing functions security analysis shows system robust various attacks analyzing search space using exhaustive key search scheme shown perform better terms search space key rate complexity comparison ofdm physical layer encryption schemes scheme offers options users customize security level key rate according hardware resource low complexity nature also makes scheme suitable resource limited devices details practical design considerations highlighted applying approach ieee ofdm system case study
paper presents new family class operational transconductance amplifier ota circuits based single stage topologies non linear current amplifiers proposed variable mirror amplifier vma architecture mainly characterized generating class current output transistors exhibiting low sensitivity technology temperature deviations avoiding need internal frequency compensation mechanism hence family otas well suited low power switched capacitor circuits specifically optimized switched opamp fast operation multi decade load capacitance specifications analytical expressions valid regions operation presented minimize vma settling time discrete time circuits also complete ota design example integrated mim cmos technology supplied detailed simulation experimental results compared resistor free state art class opamp ota literature proposed architecture returns highest measured figure merit value
paper presents new four inputs one output voltage mode universal filter using single ended operational transconductance amplifiers otas grounded capacitors appropriately connecting input terminals proposed circuit provide low pass band pass high pass band stop pass voltage responses filter also offers orthogonal control natural frequency quality factor adjusting biasing currents otas performances proposed filter simulated pspice confirm presented theory
paper presents new method transmission loss allocation based complex power flow tracing building previous works author paper presents generalized model transmission line used building block complex power flow tracing algorithm developed line model similar famous generalized circuit constants abcd model abcd line model relates voltage current one end line end developed line model relates partial flows caused load generator receiving sending end line partial flows caused load generator lines following line upstream downst ream direction proposed model properties regarding series parallel equivalence similar abcd model difference proposed model parameters determined based line flows whereas abcd parameters functions line constants although power flow tracing algorithm employed similar previously proposed author modification introduced paper enables insight loss allocation process cross effects active reactive power flows active reactive losses quantified clearly paper also describes method loss allocation presence loop flows based signal flow graph manipulation techniques
paper presents new method automatically generate hierarchical placement rules crucial successful analog placement method based novel symmetry computation method introducing structural signal flow graph five types proximity matching symmetry constraints determined according priority constraint types constraint requirement graph hierarchical partitioning circuit matching proximity symmetry groups automatically computed based experimental results state art placement tool show new approach generates placement rules lead better circuit performance parametric yield according post layout simulation
paper presents new method zbus algorithm combined forward backward algorithm deal power flow calculation distribution network ring net topological structure network analyzed decomposing branch network radial parts ring net parts forward path concept signal flow graph using forward backward algorithm radial parts calculation speed greatly improved adopting parallel calculation zbus algorithm used ring net parts voltage power boundary nodes corrected two parts calculation result keep whole network calculation consistency finally practical example analysis shows method processes ring network problems well also improves calculation speed
paper presents new parallel domain decomposition algorithm based integer linear programming ilp mathematical optimization method minimize computation time coastal ocean circulation models ilp decomposition algorithm divides global domain local domains balanced work load according number processors avoids computations many land grid cells possible addition maintains use logically rectangular local domains achieves exact results traditional domain decomposition algorithms cartesian decomposition however ilp decomposition algorithm may converge exact solution relatively large domains overcome problem developed two ilp decomposition formulations first one complete formulation additional restriction although impractical large global domains second one feasible imposes local domains dimensions looks feasibility decomposition allows much larger global domains parallel performance ilp formulations compared base cartesian decomposition simulating two cases newly created parallel version stevens institute technology estuarine coastal ocean model secom simulations ilp formulations run always faster ones base decomposition complete formulation better feasible one applicable addition parallel efficiency ilp decomposition may greater one
paper presents new payload platform precision devices possesses capability isolating complex space micro vibration low frequency range novel payload platform equipped smart material actuators investigated designed optimization strategy based minimum energy loss rate aim achieving high drive efficiency reducing effect magnetic circuit nonlinearity dynamic model driving element established using lagrange method performance designed payload platform discussed combination controlled auto regressive moving average carma model modified generalized prediction control mgpc algorithm finally experimental prototype developed tested experimental results demonstrate payload platform impressive potential micro vibration isolation elsevier ltd rights reserved
paper presents new state space model interpolation local estimates technique compute linear parameter varying lpv models parameter dependent systems using set linear time invariant models obtained fixed operating conditions technique based observability controllability properties three strong appeals compared state art literature first works continuous time well discrete time multiple input multiple output systems depending multiple scheduling parameters second technique automatic extent sense model selection user interaction required different steps method third resulting interpolating lpv model numerically well conditioned used modern lpv control design moreover proposed technique guarantees local models coherent state space representation encompassing existing results particular case benefits approach demonstrated simulation example experimental data set obtained vibroacoustic setup
paper presents new stochastic operation scheduling model microgrid day ahead electricity market considering forecast uncertainties wind generations microgrid load locational marginal price point common coupling well uncertainties pertaining availability generation units microgrid financial risk caused uncertainties modeled conditional value risk criterion proposed approach formulated risk minimizing two stage stochastic model based mixed integer linear programming framework model minimizes expected scheduling cost together cost financial risk impacts different uncertainty sources model results grid connected islanded operation modes extensively studied additionally higher effectiveness proposed stochastic model compared common deterministic approach regarding total operation cost convergence behavior illustrated sample analysis
paper presents new technique online set membership parameter estimation linear regression models affected unknown bounded noise orthotopic approximation set feasible parameters updated time step proposed technique relies solution suitable linear program whenever new measurement leads reduction approximating orthotope key idea preventing size linear programs steadily increasing propagate binding constraints optimization problems numerical studies show new approach outperforms existing recursive set approximation techniques keeping required computational burden within order magnitude copyright john wiley sons ltd
paper presents nonintrusive method automatically identify compensate current measurement errors interior permanent magnet synchronous motor ipmsm drives ipm motor distinct short circuit current speed characteristic solely defined machine design controlling ipm motor operate steady state short circuit current coasting phases ipm motor safely short circuited using inverter without introducing current transients axis currents measured inverter compared known short circuit characteristic ipm motor distortion pattern axis currents contains information needed correct current sensor errors ipmsm drives
paper presents nonlinear control technique based feedback relay systems photovoltaics applications converters inverters describes design control law state equations buck converter analysis limit cycles stability systems obtain digital control law simulation implementation programmable logic devices pld performed programming control technique hardware description language vhdl later implement cpld development prototype buck converter finally simulations tests prototype realized obtaining optimal results performance
paper presents nonlinear power system stabilizer based pointwise min norm control law third order state space mathematical model synchronous generator connected transmission lines power system commonly mathematical model includes transient electromotive force state variable measured therefore mathematical model transformed form containing measurable variables furthermore control law proposed stabilizer also considers voltage regulation proposed algorithm implemented digital control system performance experimentally verified kva synchronous generator connected power system experimental results referring change voltage mechanical power reference disconnection transmission line three phase two phase short circuit forced oscillations presented compared pssa stabilizer experimental results show better performance excitation system proposed stabilizer compared system conventional voltage controller pssa stabilizer furthermore results show proposed stabilizer robust system changes case small large disturbances well near generator stability limit elsevier rights reserved
paper presents novel approach tuner modeling called composite modeling analog blocks composed analytical models obtained selecting configuring merging pre defined attributes attributes closed form analytical representations analog signal processing functions gain filtering frequency conversion etc non idealities considered noise nonlinearity carrier frequency offset imbalance etc framework modeling tuners based object oriented programming developed using method enables development well structured yet fully scalable reconfigurable models thus easy maintain refine adding new features also class hierarchy object oriented implementation given usefulness flexibility proposed approach demonstrated example modeling analysis dvb tuner passband equivalent baseband simulation
paper presents novel approach post processing numerical weather prediction nwp grid models extract ambient air temperature predictions sub grid locations technique estimates air temperature observations nwp model using novel bank kalman filters kfs operate tandem accurately predict air temperature hours ahead desired node point campus based photovoltaic solar energy resource cork institute technology cit accurate prediction resource also important meet essential heating system deployment scheduling domestic heating conservation essential services fruit growers hospitals range air temperature sensitive applications nwp model outputs predicted air temperature values cork airport cit bank derives hour look ahead temperature schedule cit applying polynomial map filter temperature bias offset two grid points order polynomial temperature model employed bank state estimator point moving averager used smoothing error state measurement covariance matrices respectively procedure accurately predicts temperature significant reduction root mean square error rmse existing methods site specific location manipulation nwp fixed grid model output fixed grid points accurate forecasted day ahead assignment electricity generation meet load demand confidently met systems operators via hour temperature prediction estimates strategic importance installed solar scheduling issue cost effective electrical network operation consequent beneficial economic return solar array installation capital investment
paper presents novel cmos folded cascode operational amplifier leads high psrr provides gain nearly equal two stage amp proposed design implemented gpdk cmos technology amp uses folded cascode structure output stage combined differential amplifier pmos input transistors achieve good input common mode range lower flicker noise important feature allows input common mode level close supply voltage proposed topology improves psrr amp used ldo applications simulations using cadence show gain phase margin degree unity gain bandwidth mhz power consumption smaller along psrr layout design shows area acquired chip approximately equal
paper presents novel double stator permanent magnet machine integrated triple rotor magnetic gear structure proposed address problems mechanical geared generators low speed applications torque transmission based three rotors consisting prime permanent magnet poles middle rotor field poles inner outer rotors proposed machine combines functions magnetic gearing electrical power generation operating principles magnetic gear generator discussed torque distribution characteristics integrated machine analysed using finite element method fem also power torque speed characteristics reported prototype fabricated tested experimentally predicted measured results validate proposed machine design
paper presents novel inexact full adder based carbon nanotube field effect transistors cntfet approximate computations soared popularity especially image processing applications proposed design generates output carry without error therefore propagation incorrect value higher bit positions avoided least relative error distance relative compared approximate full adders reported literature practical simulations using matlab demonstrate higher peak signal noise ratio psnr image quality motion detector image processing application hspice simulations also confirm effciency proposed design moreover area occupation investigated using electric tool power consumption delay area important evaluating factors subject comparisons made comprehensive parameter pdaedp based new design higher performance tga tga axa axa axa respectively
paper presents novel multiphase permanent magnet synchronous machinery series adopting two adjacent coils per phase modular stator machine design principles including modular stator design segmental interior assisted rotor design winding factor improvement investigated moreover analytical modeling winding inductance developed provide insights magnetic circuit type machine proposed machinery series suitable wheel driving electric vehicles attributing high magnetic isolation feature good flux weakening capability feasibility modular fabrication
paper presents novel speed tracking control approach based model predictive control mpc framework autonomous ground vehicles switching algorithm without calibration proposed determine drive brake control combined simple inverse longitudinal vehicle model adaptive regulation mpc algorithm make use engine brake torque various driving conditions avoid high frequency oscillations automatically simplified quadratic program solving algorithm used reduce computational time approach applied bit microcontroller performance proposed approach evaluated via simulations vehicle tests carried range speed profile tracking tasks well designed system structure high precision speed control achieved system robustly model uncertainty external disturbances yields faster response less overshoot controller elsevier ltd rights reserved
paper presents novel two step method automated design self stabilization first step enables specification legitimate states intuitive imprecise specification desired functional behaviors set legitimate states hence term shadow creating shadow specifications systematically introduce main variables topology desired self stabilizing system subsequently devise parallel complete backtracking search towards finding self stabilizing solution implements precise version shadow behaviors guarantees recovery legitimate states state best knowledge shadow puppet synthesis first sound complete method exploits parallelism randomization along expansion state space towards generating self stabilizing systems synthesized existing methods validated proposed method creating sequential parallel implementation context software tool called protocon moreover used protocon automatically design three new self stabilizing protocols conjecture require minimal number states per process achieve stabilization processes deterministic state maximal matching bidirectional rings state token passing unidirectional rings state token passing bidirectional chains
paper presents numerical parametric study behavior bearing reinforcement earth bre wallswith different backfill properties using finite element method software plaxis primary objective study improve understanding bearing stress settlement lateral earth pressure horizontal wall movement bre walls different backfill materials second objective study evaluate effects various soil structure interactions foundations stiffness reinforcements horizontal wall deformations backfill materials consisted four types soil mixtures silty clay sand different fine contents dry weight model parameters numerical simulation obtained conventional laboratory tests back calculated laboratory pullout tests bearing reinforcement geotextile elements used model bearing reinforcements converting contribution friction bearing resistances equivalent friction resistance represented soil bearing reinforcement interaction ratio inter values inter decreased following polynomial function increase fine content ranges numbers transverse members respectively simulated bearing stress reinforced zone decreased front back wall bre wall behaved rigid body built relatively firm foundation retaining unreinforced backfill foundation settlement decreased facing wall unreinforced zone backfill properties due slight rotation wall relationship maximum horizontal wall movement fine content expressed polynomial function maximum horizontal wall movement significantly increased fine content increased excessive movement realized fine content greater increase fine content moved location maximum wall movement higher mid top wall numerical parametric study conducted investigate soil structure interaction foundation stiffness reinforcement parameters affected horizontal wall deformation especially important serviceability bre walls knowledge gained study provides preliminary guideline predicting behavior bre walls may used investigate bre walls different wall heights features bearing reinforcements
paper presents parametric study recently proposed concentrating photovoltaic concentrating solar power cpv csp hybrid system based energy exergy analyses steady state physical model established hybrid system carry energy exergy analyses general trapezoidal shaped distribution concentrated solar energy flux density employed effects various parameters investigated including average optical concentration ratio outlet temperature solar thermal receiver coolant saturation vapor temperature results show generating efficiency power output hybrid system increase compared cpv alone system indicates proposed hybrid system great potential increase utilization ratio solar energy increasing average optical concentration ratio decreasing outlet temperature solar thermal receiver result evident increases energy efficiency exergy efficiency hybrid system also shown energy exergy efficiencies organic rankine cycle orc subsystem nearly independent direct normal irradiance dni hybrid system always operated high efficiency despite dni change different moments days elsevier ltd rights reserved
paper presents photovoltaic system maximum power point tracking mppt facility goal work maximize power extraction photovoltaic generator pvg goal achieved using sliding mode controller smc drives boost converter connected pvg load system modeled tested matlab simulink environment simulation sliding mode controller offers fast accurate convergence maximum power operating point outperforms well known perturbation observation method sliding mode controller performance evaluated steady state load varying panel partial shadow disturbances confirm conclusion practical implementation maximum power point tracker based sliding mode controller hardware setup performed dspace real time digital control platform data acquisition control system conducted around dspace controller board rti environment experimental results demonstrate validity proposed control scheme stand alone real photovoltaic system elsevier ltd rights reserved
paper presents process management framework multisensory data fusion purpose tracking progress construction activity developed framework facilitates required type data fusion given point construction progress reliably efficiently data acquired high frequency automated technologies three dimensional imaging ultrawideband uwb positioning addition foreman reports schedule information information sources results validation detailed field implementation project show developed framework fusing volumetric positioning project control data successfully address challenges associated fusing multisensory data tracking activities rather objects feature offers superior capability efficiency accuracy length project contributions research include development fusion processes performed higher levels data fusion instead traditional low level fusion algorithms thus supporting decision making processes number automated construction management applications construction progress tracking earned value estimation schedule updating american society civil engineers
paper presents proposed design leg rehabilitation system system implemented reconfigurable wheelchair prototype order provide additional two rotational degrees freedom dof serving rehabilitation purposes lagrangian dynamic formulation used derive system dynamics joints frictions based coulomb friction model considered leg rehabilitation system system equations motion linearized since model dealt state space representation lqr control approach considered derived stabilization system simulation results validating model control approach presented discussed
paper presents real time image acquisition system improved image quality assessment module acquire high quality near infrared nir images thermal imaging plays vital role wide range medical military applications demand high throughput image acquisition image processing continuously increased especially critical medical military purposes executions real time constraints required work implements nir image quality assessment module utilizes improved two dimensional entropy mask based edge detection algorithms effectiveness proposed image quality assessment algorithms demonstrated implementation complete finger vein biometric system proposed model implemented embedded system field programmable gate array prototyping platform including image quality assessment module proposed system able achieve recognition accuracy equal error rate handle real time processing frames live video rate achieved hardware acceleration proposed image quality assessment algorithms via novel streaming architecture
paper presents real time operating system rtos implementation rtos based osek standard extended support asymmetric multiprocessor system amp term asymmetric means microprocessors included system heterogeneous architectures subgroup identical processors may exist whole amount identical processor executes instance rtos specifically designed optimised also description development process took place communicate rtos instance taking advantage hardware features order exchange information processors provided finally functional test application presented processors monitor using rtos resources keep alive events sharing information gpio activity reporting changes system status using serial communication addition energy consumption analysis performed test case hardware platform used development argentine open industrial computer computadora industrial abierta argentina ciaa based lpc dual core amp microcontroller includes arm cortex armve architecture acting master microprocessor arm cortex armv architecture slave coprocessor
paper presents sensitivity analysis pharmaceutical direct compaction process sensitivity analysis important tool gaining valuable process insights designing process control concept examining results systematic manner makes possible assign actuating signals controlled variables paper presents mathematical models individual unit operations sensitivity analysis based two sensitivity analysis methods outlined based called sobol indices based steady state gains frequency response proposed plant model elsevier rights reserved
paper presents smart way actuate control airfoil shape morphing wing open loop architecture actuation system uses smart material actuators shape memory alloys disposed two parallel actuation lines control performed mamdani type fuzzy logic proportional derivative controller morphing wing project description actuation system structure control design validation highlighted paper results obtained numerical simulation experimental validation bench tests wind tunnel tests presented part control design validation analysis wind flow characteristics based information provided pressure sensors mounted flexible skin morphing wing wind tunnel tests included supplementary validation transition laminar turbulent flows real time visualized aerodynamic efficiency controlled morphing wing evaluated american society civil engineers
paper presents study generation mechanism wind induced vibration suspenders suspension bridges wake bridge towers computational fluid dynamics cfd simulation carried characterize wind flow wake bridge towers different wind directions time series force coefficients suspenders determined clearly show dominant frequency component associated vortex shedding towers wind tunnel test program also implemented measure wind induced vibration suspenders different wind speeds directions results show vortex shedding bridge towers strong influence aerodynamic forces suspenders wide range wind directions suspenders vibrate longitudinal transverse directions large amplitude vibration suspenders observed vortex shedding frequency towers coincides frequency suspenders
paper presents study use low resolution infrared images detect ticks cattle emphasis given main factors influence quality captured images well actions increase amount information conveyed images addition new automatic method analyzing images counting ticks introduced proposed algorithm relies color transformations simple mathematical morphology operations thus easy implement computationally light tests carried using large database containing images neck hind end animals observed proposed algorithm effective detecting ticks visible images even contrast background high hand due intrinsic extrinsic factors thermographic images used study always succeed cleating enough contrast ticks cattle hair coat although problems mitigated following directives currently rough estimates tick counts achieved using infrared images low spatial resolution elsevier rights reserved
paper presents systematic socio technical empirical evaluation actual energy environmental performance sustainably designed institutional building southeast england intended teaching tool living laboratory sustainability despite building designed high sustainability standards energy performance certificate rating low reliance fossil fuels natural ventilation rainwater harvesting also utilised use stage lower hours occupation number occupants actual energy related carbon dioxide equivalent emissions four times predicted due poor energy management building underperformance biomass boiler wasteful energy practices terms excessive winter overheating atrium inappropriate lighting controls electrical equipment left standby due lack training understanding energy manager building management system used adequately issues installation commissioning maintenance biomass boiler led disuse however photovoltaic system generated electricity expected findings study show mixed methods approach building performance evaluation bpe embedded part build process ensure performance outcomes met reality elsevier rights reserved
paper presents technique reduce torque ripple fractional slot brushless machine slot pole machine equipped various stators design subject investigation better torque performance rated condition desirable additional permanent magnets inserted stator part design optimization process motor topology performed order obtain best torque performance shown significant reduction torque ripple achieved without losing desired average torque influences proposed stator design back emf output torque cogging torque analysed compared initial machine design
paper presents two dimensional numerical model nearshore random wave transformation focus model calibration verification laboratory field data model based energy balance equation including diffraction dissipation terms mase energy dissipation determined based formulation dally new expressions stable wave height decay coefficients coefficients estimated based local beach slope offshore wave conditions model calibrated several data sets large scale sediment transport facility lstf coastal hydraulics laboratory usa model verified large number data sets including lstf data cases structures laboratory data great wave flume hanover field data egmond netherlands duck usa cancun mexico validation showed model could reproduce observations well relative root mean square error varies laboratory data field data coefficient determination varies demonstrating good agreement model measurements
paper presents vlsi design methodology mac level dwt idwt processor based novel limited resource scheduling algorithm split fully specified signal flow graph fsfg limited resource fir filtering developed scheduling mac level dwt idwt signal processing given set architecture constraints dwt parameters scheduling algorithm generate four scheduling matrices drive data path perform dwt computation memory inter octave considered register fir filter memory size less traditional architecture besides based limited resource scheduling algorithm automated dwt processor synthesizer developed generates constrained dwt processors form silicon intelligent property sip dwt sip embedded soc mapped program codes commercial shelf cots dsp processors programmable devices result successfully proven variety dwt sips efficiently realized tuning parameters applied signal processing applications
paper presents active aerodynamic control method flutter oscillation long span suspension bridges newly designed twin winglet system key point paper establish theoretical framework active control bridge flutter pair rotatable winglets beyond deck motions determined feedback control algorithm utilizing aerodynamic forces generated winglets active control system improve aerodynamic stability long span suspension bridges extent modeling control system mainly focus practical feasibility relative rotations rather driving forces winglets selected control variables paper state space expression control system proposed handle problems high order terms elimination decoupling control variables since unobservability aerodynamic states model reduction technique adopted design observer controller active control algorithm presented paper verified numerical simulations stabilizing mechanism energy consumption discussed well shows good effectiveness robustness active aerodynamic control device wide range wind speeds flutter suppression elsevier ltd rights reserved
paper presents analysis state art solutions mapping relational database ontology adding reasoning capabilities offering possibility query inferred information analyzed four approaches jena drq jena rrml kaon owl api order highlight differences four approaches used nutrition diagnostics related ontology definition concepts rules relational database storage individuals performance evaluation focused time required map relational database ontology time required retrieve information inferred diagnostics number people obtained results show best performance cases given kaon
paper presents analytical model force torque developed reaction sphere actuator satellite attitude control reaction sphere innovative momentum exchange device consisting magnetic bearings spherical rotor electronically accelerated direction making three axes stabilized spacecrafts controllable unique device spherical actuator composed pole permanent magnet spherical rotor coil stator force torque analytical models derived solving laplace equation applying lorentz force law novelty consists exploiting powerful properties spherical harmonic functions rotation derive closed form linear expressions forces torques possible orientations rotor specifically orientation rotor parametrized using seven decomposition coefficients determined noniteratively linear fashion measuring radial component magnetic flux density least seven different locations therefore force torque models possible orientations rotor expressed closed form linear combination mutually orthogonal force torque characteristic matrices computed offline proposed analytical models experimentally validated using developed laboratory prototype
paper presents architecture lifting based running discrete wavelet transform dwt powerful image video compression algorithm proposed design one first lifting based complete dwt architectures without group pictures restriction new computing technique based analysis lifting signal flow graph minimizes storage requirement architecture enjoys reduced memory referencing related low power consumption low latency high throughput compared earlier reported works proposed architecture successfully implemented xilinx virtex series field programmable gate array offering speed mhz making suitable real time compression even large frame dimensions moreover architecture fully scalable beyond present coherent daubechies lterbank
paper presents error budget methodology designing characterizing machines used manufacture inspect parts spatial frequency based specifications methodology static dynamic error considered error budget static error affects figure accuracy dynamic error introduces spatial frequency domain error error caused components machine tool cutting process external interference considered paper using error budget able minimize risk initial stages ensuring machine produce components meet specifications machine actually built purchased methodology used predict improve performance ultraprecision flycutting machine tool
paper presents exergy environmental analysis novel trigeneration system biomass solar energy coupling utilization novel trigeneration system mainly consists biomass gasifier solar collector internal combustion engine absorption unit liquid desiccant unit solar collector provides steam biomass gasification process product gas fed internal combustion engine generating electricity flue gas utilized absorption unit cooling production heat exchanger domestic hot water successively jacket water considered low heat resource generating desiccant capacity exergy efficiency exergy destruction emissions analyzed different parameters results show total exergy efficiency trigeneration system case study determined solar energy contributes decrease consumption biomass also found highest exergy destruction takes place gasifier follow internal combustion engine gas water heat exchanger addition introduction biomass solar energy alleviates impact environment mainly reduces emissions emissions decrease evidently compared separated generation system elsevier ltd rights reserved
paper presents experimental investigation specimens manufactured selective laser sintering sls purposes giving designers advice designing printed parts laying basis step forward field fracture mechanics complex parts aim investigate effect building direction polyamide printed samples assess whether crack initiated directly sintering process fracture mechanics study purposes six different configurations mode compact tension specimens manufactured tested experiments monitored digital image correlation dic fractured surfaces analyzed using microscopy results showed samples better mechanical performance layers contain portion crack hand layers parallel crack plan offer preferential pathway crack propagate dic fractography investigations showed certain conditions small radius geometries close surfaces may bond together depending printer resolution experiments also showed sls capable printing specimens internal cracks used study fracture mechanics complex parts parts internal cracks elsevier ltd rights reserved
paper presents innovative approach based hardware software develop multichannel seismic monitoring data acquisition embedded system hardware designed using basic electronic components integrated circuits consists two parts signal processing microcontroller circuits signal processing circuit combination preamplifier low pass filter gain control high pass filter offset clipper circuits proposed data acquisition system able record data sampling rate bit resolution three modes real time monitoring continuous recording seismic refraction detected seismic signals filtered using analog filters low pass khz high pass universal serial bus utilized communicate hardware personal computer graphical user interface based windows operating system developed using microsoft net framework transferring processing analyzing data system tested experimental results showing performance proposed system presented earth scientists use system educational seismic experiments easily modified used engineering applications
paper presents integrated system used ultra precision machine tool upmt design conceptual fundamental design stage system based dynamic thermodynamic error budget theories candidate configurations machine tool first selected configuration library novel configuration designed user according functions machine tool expected realize appropriate configuration given comparing stiffness chain dynamic performance thermal performance error budget candidate configuration consequently integrated design system enables conceptual fundamental upmt designed efficiently theoretical foundation proposed system used several upmt designs demonstrate effectiveness integrated design system
paper presents optimal bid submission day ahead electricity market problem joint operation wind photovoltaic power systems energy storage device uncertainty due electricity market price also due wind photovoltaic powers one main characteristics submission problem formulated two stage stochastic programming problem optimal bids energy flow batteries first stage variables energy deviation second stage variable problem energy storage way harness renewable energy conversion allowing store discharge energy conveniently market prices case study data iberian day ahead electricity market presented comparison joint disjoint operations discussed elsevier ltd rights reserved
paper presents upcoming method searching optimal placement phasor measurement units pmus power system state estimation proposed technique based phasor technology allows estimate current status electrical network reliable accurate way fact looking full system observability must take account lack availability appropriate data network nodes well intervention renewable energy sources investigations facts systems extended enhance smart grid performances stability experimentally application efficient placement strategies help allocate pmus critically bus test system
paper presents analysis two mesh map strategies applied unwrap images rock tunnels facilitate visualization large datasets first examined mesh parameterization algorithms used computer graphics convert mesh model representation found methods automatic could provide maps minimal metric distortion conservation lengths mapped exhibited twisted shapes intuitive interpret second proposed two novel approaches combining mesh deformation algorithms used computer animation reshape mesh resemble plane projection onto plane found methods required user interaction introduced greater amount metric distortion outputs fairly intuitive interpret compare relative merits mesh parameterization mesh deformation projection different strategies applied wide long high subsection mining tunnel metric distortion produced calculated respective output maps presented discussed elsevier ltd rights reserved
paper presents demaware ambient assisted living framework support care people dementia framework integrates various sensor modalities ambient wearable offline cloud based together sophisticated interdisciplinary methods including image audio semantic analysis fine grained atomic events object manipulation aggregated complex activities semantic fusion applications tailored monitoring dementia symptoms support clinicians drive effective timely interventions evaluate outcomes framework evaluated robustness reliability clinical value real world lab trials home installations elsevier rights reserved
paper presents development energy efficient fault tolerant control multiphase nonsinusoidal synchronous machines making use hamiltonian optimal control theory analytical solution optimal linearization control derived closed form eliminates machine torque ripples maximizes machine efficiency defers output voltage saturation nonconstant operational torque speed controller achieve voltage torque linearization even faulty motors open circuited phase making suitable high risk applications study complemented presenting optimal indirect torque control scheme based internal current feedback loop finite bandwidth simulation experimental results appended underpin performance energy efficient fault tolerant controller
paper presents estimates monetary value impact eutrophication algae commercial agriculture two different catchments south africa production function approach applied estimate monetary value impact filamentous green algae commercial agriculture dwars river western cape loskop irrigation area groblersdal south africa main emphasis impacts algal growth farm profitability relied detailed information impact extent impact algae farming practice paper presents study areas methodological approach surveyed pollution impacts calculated monetary value impacts pollution short conclusion discusses potential applications results initial results point towards value per hectare per year dwars river area per hectare per year loskop irrigation area information used compare different eutrophication mitigation strategies within study areas lesser extent similar areas outside areas also inform process focusing assessing market potential tradable pollution permits mitigation practice manage water pollution catchments
paper presents integrated circuit fault detection printed circuit board pcb model using thermal image processing thermal image captured processed pcb model finite element method fem histogram features extracted ics hotspots used inputs classifier model effective features minimized principal component analysis method work comparative study image classification detection performed based three soft computing techniques multilayer perceptron support vector machine adaptive neuron fuzzy inference system effectiveness models evaluated comparing performance accuracy classification validate model experimental evaluation performed arduino uno order detect fault condition real time operating pcb elsevier ltd rights reserved
paper presents new approaches regarding use product lifecycle management concept achieve knowledge integration academic disciplines maritime education context philosophy educational system changing faster worldwide continuous developing process demand develop modern educational facilities cad cae cam training future maritime engineers offers collaborative environments academic disciplines teachers well known students must understand importance connectivity academic disciplines computer aided methods interface thus besides basic knowledge competences acquired cad courses students learn increase design productivity create parametric design original instruments automatic design printing methods interface cad cae cam applications example strength materials discipline briefly presents alternate computer aided methods compute geometrical characteristics cross sections using cad geometry creation free body diagrams presentation deflected shapes various educational models including rotational effect forces applied shear center using results fem applications computer aided engineering academic disciplines students design analyze virtual model convert physical object using printing method constanta maritime university offers full understanding concept product lifecycle management collaborative creation management dissemination
paper presents research cognitive vehicle energy management low cost hybrid electric vehicle hev power systems small vehicles terrain vehicles atvs power system consists small engine lead acid battery ultracapacitor simplicity implementation low hardware cost engine control restricted two states vehicle speed control restricted three discrete levels namely high medium low authors developed advanced algorithms modeling optimizing vehicle energy flow machine learning optimal control settings generated dynamic programmling real world drive cycles intelligent energy controller designed online energy control based knowledge driving mission knowledge obtained machine learning intelligent vehicle energy controller cognitive intelligent power management cipm implemented evaluated simulated vehicle model atv polaris ranger converted hev experimental results show intelligent energy controller cipm lead significant improvement fuel economy compared existing conventional vehicle controllers atv
paper presents results series undrained monotonic compression tests loose sand reinforced geotextile mainly study effect confining stress mechanical behaviour geotextile reinforced sand triaxial tests performed reconstituted specimens dry natural sand prepared loose relative density without geotextile layers consolidated three levels confining pressures kpa different numbers different arrangements reinforcement layers placed different heights specimens layers behaviour test specimens presented discussed test results showed geotextile inclusion improves mechanical behaviour sand significant increase shear strength cohesion value obtained adding layers reinforcement also results indicate strength ratio pronounced samples subjected low value confining pressure obtained results reveal high value confining pressure restrict sand shear dilatancy effect reinforcement efficiently
paper presents results study evaluate energy conversion potential innovative electrical generator employing ybco superconductor thin film disk rotor creating rate change flux magnetic field using flux repulsion property superconductors electrical generator realized using ansys simulation simplified experimental set feasibility design concept proposed device evaluated different magnetic field strengths different rotating speeds superconductor disk
paper presents analysis design hardware implementation digital polynomial regulation steady state error tracking rst current controller based third harmonic modulated boost type power factor correction pfc rectifier proposed rectifier used front end vector controlled induction motor drive vcimd eliminate harmonics input supply proposed pfc rectifier modifies input current sinusoid unity power factor apart offering bus voltage regulation paper digital proportional integral rst current controllers compared terms total harmonic distortion thd power factor point common coupling different loading conditions rst current controller tracks set point accurately zero steady state error offers good disturbance rejection enables reduction supply current thd compared conventional current controller control algorithm pfc front end rectifier along vector control technique implemented using digital signal processor dynamic performance analyzed step changes reference speed load torques demonstrating significant improvement performance indices
paper presents application differential evolution algorithm obtain optimal switching angles single phase seven level improve voltage quality proposed inverter article composed two bridge cells non equal voltage sources order generate multiple voltage levels selective harmonic elimination pulse width modulation shpwm strategy used improve output voltage waveform generated proposed inverter differential evolution optimization algorithm used solve non linear transcendental equations necessary shpwm computational results obtained computer simulations presented good agreement theoretical predictions laboratory prototype based stmf microcontroller built order validate simulation results experimental results show effectiveness proposed modulation method
paper presents design test results biaxial excitation generator motor automobiles bega three phase stator salient pole excited heteropolar rotor multiple flux barriers filled low cost permanent magnets new generator low voltage regulation obtained flux barrier combination field excitation low power control full power diode rectifier stator good power volume superior efficiency obtained costs comparable existing lundell generator generator configuration principle equations finite element field analysis design optimization performance characteristics test results together generating system simulations make core paper
paper presents design experimental validation series rotary elastic actuator sea actuator conceived installed knee ankle joint version three humanoid robot icub actuator composed electric motor gearbox customized torsion spring stiffness value torsion spring outcome optimisation problem considers several criteria maximum readable torque sea total stiffness mechanism synthesis elastic element exploits finite element method fem allows meet requirements experiments conceived design performed custom set verify match desired real value mechanism stiffness maximum resultant error estimation damping associated sea also performed experimental validation
paper presents design order mult istage feedforward operational amplifier amp applications continuous time bandpass delta sigma modulators system level design procedure proposed determine transconductance stage transistor level curren treusing emphasized achieve power efficiency simulated cmos process amp achieves gain mhz gain ghz power consumption
paper presents design fuzzy logic based voltage regulated solar power maximum power point tracking mppt system applications involving hybrid power systems system contains solar power system battery primary secondary power sources respectively solar system alone supplies power electric motor maintains output voltage predetermined level sufficient power solar power insufficient solar system operated maximum power point mpp battery engaged compensate insufficiency first variant incremental conductance mpp condition established mpp condition voltage regulated mppt system formulated feedback control system mpp condition voltage regulation requirements used system inputs next fuzzy controller developed perform voltage regulated mppt function hybrid power system simulation model based matrix laboratory matlab simulink block diagram environment multi domain simulation model based design piecewise linear electric circuit simulation plecs tool controlling motor velocity developed verify voltage regulated solar power mppt system
paper presents design novel electronic voting machine using microcontroller voter information facility also incorporated machine design information number voters present polling place stored register later used various analyses infrared sensors used determining voter information design proposed special option vote rejection present conventional systems simulation system done proteus professional software multiple vote casting avoided using software coding techniques design presented paper appropriate simulation working properly normal conditions
paper presents design sliding mode control smc trajectory tracking unmanned aerial vehicle uav quadrotor simplified model quadrotor used controller design robustness controller verified simulations also data analysis experiments arducopter platform smc algorithms implemented microcontroller communicates human machine interface hmi monitors behavior stability state variables results show effectiveness control technique maintaining stability quadrotor different operating scenarios
paper presents design inner rotor permanent magnet motor using two step approach first step consists retrieving basic geometric electric constants using combination analytic multi objective genetic algorithm technique allows efficient cheapest motor certain type home appliances application found harmonics neglected optimization design assumption implies iron losses relevant stator domains peculiarity optimization motor fact efficient operating point located one tenth maximum load electric motor second step consists comparing resulting optimized motor using finite element analysis step crucial accurately compare efficiency resulting drive analytic results advantage using tool also include effect different space harmonics efficiency computation harmonics rotate different speed rotor produce additional losses rotor iron parts agreement results two step analysis infers effect space harmonics relevant drive decay efficiency due space harmonics order
paper presents design observation operator assimilation global navigation satellite system gnss radio occultation refractivity related operational implementation strategy global grapes variational data assimilation system preliminary assessment data assimilation effect performed results show data one important observation types grapes significant positive impact analysis forecast ranges especially southern hemisphere global stratosphere situ measurements lacking grapes model error controlled southern hemisphere without data assimilated addition found data play key role stable running grapes global assimilation forecast system even relatively simple global data assimilation experiment conventional data assimilated system able run nine months without drift compared ncep analyses analysis skills northern southern hemispheres still relatively comparable even nine month integration especially stratosphere number conventional observations decreases observations uniform global coverage dominate gradually
paper presents experience mercy corps community based initiatives water demand management project five year project terms community based initiatives water management project designed build capacity local community based organizations cbos raise awareness level around water demand management wdm engage community members water management measures showed local solutions decrease reliance public water systems ultimately help facing water shortage national level paper also showed site rainwater harvesting cisterns funded project able harvest annually paper found rainwater harvesting household level able save average potable water per year elsevier rights reserved
paper presents vivo performances resource optimized digital action potential detector featuring adaptive threshold based new sigma delta control loop proposed detector optimized utilizing low hardware resources makes suitable real time implementation common low power microcontroller units mcc adaptive threshold calculated using digital control loop based sigma delta modulator precisely estimates standard deviation neuronal signal amplitude detector demonstrated using common mcc msp family incorporated small wireless platform combined optogenetics neural recording system fully characterized experimentally within vivo experiments freely moving transgenic mouse expressing channelrhodospin thyl chr yfp line results demonstrate proposed detector used achieve overall data reduction ratios transmitting detected aps comparison obtained results thresholding approaches shows proposed detector provides similar performances significantly resource demanding approaches
paper presents mechanism robust control monolithic wire clamp achieve fast precision operations strong robust micro device packaging wire clamp piezoelectrically actuated two stage flexure based amplification designed obtain large parallel jaw displacements grasping forces wire clamp evaluated based finite element analysis fea force measurement presented wire clamp manufactured using wire edm technique position force transfer functions obtained based frequency response approach position force switching control strategy employed regulate motion position grasping force position force switching controller composed pid controller position control sliding model controller smc force control designed experimental tests carried investigate performance wire clamp position force switching controller grasping releasing operations results show wire clamp exhibits good performance demonstrate high speed precision grasping operations realized developed wire clamp control strategy elsevier ltd rights reserved
paper presents modeling control hybrid wind tidal turbine hydraulic accumulator hybrid turbine captures offshore wind energy tidal current energy simultaneously stores excess energy hydraulic accumulator prior electricity generation two hydraulic pumps installed respectively wind tidal turbine nacelles used transform captured mechanical energy hydraulic energy extract maximal power wind tidal current standard torque controls achieved regulating displacements hydraulic pumps meet output power demand proportion integration differentiation pid controller designed distribute hydraulic energy accumulator pelton turbine simulation case study based combining offshore wind turbine tidal current turbine undertaken case study demonstrates hybrid generation system captures available wind tidal energy also delivers desired generator power precisely accumulator damping power fluctuations wind tidal speed disturbances energy exergy analyses show energy efficiency exceed small input speeds considered exergy efficiency consistent change trends demand power parametric sensitivity study hydraulic accumulator shows inversely proportional relationship accumulator hydraulic equipments including pump nozzle terms dimensions elsevier ltd rights reserved
paper presents principles sampled analog signal processor sasp dedicated software radio mobile device many technological bottlenecks overcome idea design discrete analog signal processor challenge theses bottlenecks main issue associated conversion thus avoided sasp aims select spectral envelope signal among signals reach target sasp processed analogically input signal spectrum thanks analog discrete fourier transform dft spectrum processed voltage samples representing signal envelope treated converted digital selection voltage samples among thousands others replaces classical mixing filtering operations dramatically reduces aid conversion frequency ghz mhz frequencies design strategy applications first time measurements presented
paper presents project ireport sportsinjuries system focus web application directed sport health professionals supporting acquisition analysis dissemination sports injuries information software allow health professionals register analyze sports injuries among sports populations application provides reporting module includes tables charts individually analyze injuries specific sports organization specific sport across organizations specific athlete independently practices system also offers module global analysis allows ireport sportsinjuries obtain incidence prevalence values besides socioeconomics costs regarding sports injuries national level order offer features based global sports injuries model goal standardizing data related sports injuries subject
paper presents recent development next generation wireless smart sensor wss platform enable accurate inexpensive greatly simplified method instrumenting structures structural health monitoring modular hardware platform features bit high precision analog digital converter eight differential channels analog input programmable antialiasing filters node measure three axes acceleration global response monitoring strain local response monitoring iii temperature high level voltage signals external sensors providing multi scale sensed information needed advanced structural health monitoring shm communication power optimized zigbee radio achieved distances extensible actor based software framework facilitates creation distributed shm applications framework employs service oriented architecture soa approach provides suite modular reusable extensible middleware services suitable wss applications platform addresses critical shm needs enabling tightly synchronized sensing addressing data loss efficiently implementing demanding numerical algorithms required system identification damage detection sensor nodes limited resources published elsevier ltd
paper presents results obtained implementation infrastructure improve technological services email virtual learning environment digital repository virtual library polytechnic agricultural higher school manabi polytechnic school agriculture manabi espam use high availability virtualization mechanisms provide reliable resources virtualization empowering cutting edge technology transforming operation technological services involves paradigm shift service oriented information technologies cloud computing execute processes cycle methodology used strategy virtualization services empowers companies institutions transforming operate forefront innovation services technological solution implementation redundant technology espam allowed technological services always operative benefit university community failures main system services backups enabled quickly allowing systems come operation immediately
paper presents results brushless permanent magnet starter generator design caters low cost manufacture highly constrained mechanical space envelope starter generator design addresses low cost requirement use aluminium winding conductors ferrite presents several challenges include limited selection appropriate machine topology realise high specific output lower performance materials minimizing power losses associated higher resistivity aluminium enhancement thermal performance problem exacerbated demanding space envelope operating requirements necessity design manufacture selection appropriate machine topology paramount present application limited mechanical space envelope results pancake like geometry aspect ratio stator outer diameter machine active length high provide solution satisfying challenging design requirements approach combining theoretical electromagnetic thermal analyses together tests machine subassemblies employed method allows informed design process manufacture assembly nuances affecting starter generator performance identified accounted prior prototyping complete machine assembly paper discusses employed design methodology detail number machine designs alternative winding constructions considered providing insight challenges limitations cost effective winding construction utilizing aluminium conductors results analysis starter generator suggest proposed machine design capable achieving design requirements continuous transient operating modes
paper presents results numerical study unsteady three dimensional natural convection power law fluid thick walled vessel driven natural heat convection surrounding air inside cubical cavity continuity linear momentum energy equations internal otswald waele shear thinning fluid power index used describe fluid mechanics natural heat transfer along conjugate continuity navier stokes energy equations external newtonian air flow transient heat diffusion equation walls inner fluid container unsteady thermal convection inner shear thinning fluid analyzed comparison fluid mechanics heat transfer results newtonian fluid two values rayleigh number thermo physical properties inner fluid allowed change temperature two values rayleigh number newtonian power law non newtonian inner fluids numerical simulations carried house fortran finite volume method parallelized code results evolution fluid mechanics described terms streamlines related unsteady convective heat transfer terms isotherms elsevier masson sas rights reserved
paper presents results two educational experiments carried determine whether process specifying requirements catalog based reuse opposed conventional specification impact effectiveness productivity located distributed software development environments participants experiments students enrolled three courses project management software development university murcia spain mohammed university rabat morocco results fixed effects meta analysis hedges obtained medium effect productivity large effect effectiveness favor using catalog based reuse process rather conventional specification process factor examined distribution either global located statistically significant interaction process used catalog based reuse conventional specification either effectiveness productivity research required study effectiveness productivity catalog based requirements engineering learning method taught software engineering courses applied real software engineering projects
paper proposed highly efficient solution thermal compensation ground coupled heat pump systems kitchen exhaust air waste heat recovery khr gchp cold climatic regions new analysis calculation method developed non finned coil heat exchangers khr gchp systems moreover two indexes defined evaluate khr gchp relevant systems thermal compensation capacity per unit energy consumption tec system specific net energy saving snes comparing analyzing trnsys simulation results experimental data concluded khr gchp system higher energy efficiency tec kwh kwh significantly higher normal boiler gchp systems kwh kwh frequently used hybrid solar gchp systems kwh kwh furthermore snes khr system reached least times high common kitchen exhaust air waste heat recovery systems ranging additionally facilitate khr gchp wide application simplified criterion developed circumstances air water temperature difference higher degrees current project suitable hybrid solar gchp system higher degrees projects khr gchp system demonstrated advantages systems elsevier rights reserved
paper proposes smart image sensor multi operation modes edge extraction centroid tracking high dynamic range imaging output operated pulse width modulation pwm sensor applied achieve high dynamic range hdr response reduce fixed pattern noise fpn array level analog signal processing asp implemented local inter pixel feedback event driven hand shaking readout prototype chip smart image sensor cis array fabricated cmos technology prototype verified demonstrate features real time edge extraction object tracking high dynamic range imaging successfully measurement results show power dissipation edge extraction mode frame rate kfps tracking error pixels centroid tracking mode high dynamic range imaging mode
paper proposes combined numerical analytical approach magnetic vibration analysis new excited multitoothed switched reluctance msr machine first machine design artfully incorporate excited winding msr topology hence breeding new flux controllable high torque low torque ripple doubly salient magnetless machine finite element method used calculate machine force torque series analytical equations formulated calculate magnetic vibration parameters proposed machine analysis process corresponding results given verify validity proposed approach magnetic vibration analysis new machine
paper proposes linear variable machine equipped set field winding capable adjusting air gap flux conventional variable reluctance machines proposed machine doubly salient structure permanent magnets windings mover distinct feature proposed machine armature winding field winding stator inviting field winding proposed machine flux control capability also realizes bipolar operation paper proposed machine design operating principle presented discussed two phase machine modular design dimensioned using three dimensional finite element analysis steady transient performances quantitatively analyzed evaluated
paper proposes macromodel emulate nonlinear behavior current feedback operational amplifiers cfoas low frequency main difference macromodel reported previously literature herein real physical active device performance parameters along parasitic elements associated input output terminals amplifier considered validate deduced behavioral model saturated nonlinear function series snfs based cfoas built numerical simulations generated point modeling problem cast terms augmented set equations unlike piece wise linear pwl approach dynamic behavior cfoa considered afterwards snfs experimentally tested using commercially available active devices confirming good agreement among theoretical simulations experimental tests two operating frequencies showing better accuracy compared pwl approach linear model cfoas derived nonlinear macromodel cfoas used generating behavioral model snfs one concludes latter also accurate efficient respect traditional techniques pwl approaches elsevier ltd rights reserved
paper proposes mathematical formulation energy management connected microgrid aim determining optimal operating strategy energy storage fulfil time varying energy demand operational constraints achieving tradeoff microgrid running costs energy storage system life microgrid composed various renewable power production plants storage devices controllable loads ability increase energy efficiency reduce costs energy purchasing main grid problem formulated mixed integer linear optimization problem optimization aimed minimizing overall cost function system satisfying customer demand safety electrical network case study existing microgrid investigated microgrid consists photovoltaic hydroelectric power plant battery storage office building industrial facility optimization problem solved efficient way using commercial software simulation results show feasibility effectiveness proposed approach satisfy load reduce total costs
paper proposes mathematical model solar dish stirling system firstly presented methodology calculate appropriate angles characterize solar tracking control system city itajuba brazil order maximize heat flow cavity receiver secondly developed algorithm sizing determine effects opto geometric parameters overall efficiency dish stirling system model allows defining different configurations geometric distances concentrator receiver order obtain desired heat receiver cavity finally carried thermal balance evaluation maximum efficiency overall efficiency system results obtained concentrator diameter solar irradiation theoretical maximum working temperature receiver surface maximum thermal efficiency observed collectors diameter overall efficiency variation significant since variation temperature receiver thermal losses cavity minimal evaluated conditions elsevier ltd rights reserved
paper proposes new electrically controlled magnetic variable speed gearing mvsg machine capable providing controllable gear ratios hybrid electric vehicle hev applications key design feature involves adoption magnetic gearing structure acceptance memory machine flux mnemonic concept hence proposed machine offer gear shifting mechanism torque speed transmission also provide variable gear ratios torque speed variation electromagnetic design studied discussed finite element method developed hysteresis model verify validity machine design
paper proposes new group based accelerating structure called hybrid structure ray tracing dynamic scenes whose main advantage choose suitable local accelerating structure object scene hybrid structure objects scene organized hierarchical bounding volume structure surface area heuristic sah cost model object group node including one object local accelerating structure constructed object hybrid structure scene divided static part dynamic part movement dynamic part updated frame addition design efficient storage format according graphics processing unit gpu storage characteristics makes easy realize parallel ray tracing gpu experimental results show hybrid structure efficient deal dynamic scene including different kinds objects easily integrated parallel application systems
paper proposes new hybrid metaheuristique algorithm based hybridization biogeography based optimization differential evolution solving optimal power flow problem emission control biogeography based optimization bbo algorithm strongly influenced equilibrium theory island biogeography mainly two steps migration mutation differential evolution one best evolutionary algorithms global optimization hybridization two methods used overcome traps local optimal solutions problems time consumption objective paper minimize total fuel cost generation total emission total real power loss also maintain acceptable system performance terms limits generator real power bus voltages power flow transmission lines present work bbo applied solve optimal power flow problems ieee bus test system algerian electrical network bus results obtained method show better performances compared bbo well known metaheuristique evolutionary optimization methods
paper proposes new mutated hybrid firefly mhf algorithm improve overall system stability optimizing gain parameters active reactive power control distributed energy resources ders microgrid system comprehensive optimization entire ders conditioning gain parameters studied terms error function minimization photovoltaic system battery energy storage bess proposed one ders microgrid bess system used auxiliary power supply improve link stability voltage source converter vsc second order pll based vsc considered grid synchronization der diesel engine pade approximation based governor control incorporated proposed microgrid low voltage weak microgrid considered confirmation increased stability limits computer simulations using matlab editor stability limits studied terms ders dynamic performance active reactive power dynamic relations order pll feedback system vsc system studied validation stability various case observations presented including microgrid operational solar irradiation deviations performance evaluation ders elsevier ltd rights reserved
paper proposes novel side discrete time voltage controller grid connected voltage sourced converters asymmetrical faults main objective eliminate second order voltage oscillation vsc side well positive sequence third order harmonic current injection grid asymmetrical faults compensator designed based comprehensive discrete time model side dynamics shown side average voltage controlled positive sequence direct axis current oscillating component fully controlled negative sequence axes currents negative sequence current references obtained using discrete resonant controller plus lead filter order achieve zero steady state error asymptotically stability without injecting harmonics currents grid simulation results showed effectiveness proposed strategy severe fault conditions elsevier ltd rights reserved
paper proposes novel nonisolated single switch cascaded high step converter converter consists coupled inductors clamp circuit cascaded capacitors achieve high step voltage output one switch used proposed converter switch reduce cost efficiently simplify control proposed converter converter also possesses energy recycle mechanism recycling spike energy leakage inductor addition clamp circuit used reduce voltage stress across switch cascaded design used reduce voltage stress across diodes output capacitor thus proposed converter select low voltage stress switch reducing circuit loss improving efficiency converter finally study nonisolated cascaded high step converter implemented input output voltages respectively microcontroller dspicf used control converter verify system effects feasibility maximum efficiency proposed converter efficiency full load copyright john wiley sons ltd
paper proposes recognition algorithm solving puzzle quickly response identification highly deviated shooting angle algorithm includes five procedures binarization processing edge detection hough transformation morphological processing projective geometry transformation simulated verified java language environment android mobile terminal environment operation implemented write find information scanning reading two dimension code
paper proposes static linear behavior slb analog fault model switched capacitor circuits circuits test cut divided functional macros including operational amplifiers capacitors switches macro specified design parameters design perspectives design parameters constitute parameter set determines practical transfer function cut slb fault model defines cut faulty parameter set results transfer functions whose frequency responses design specification analyzed fault effects macros derived faulty signal flow graph models faulty transfer function templates cut automatically generated based templates proposed test procedure estimate parameters parameter set test cut multiple faults different conventional single fault assumption proposed slb fault model covers concurrent multiple parametric faults catastrophic faults addition need conduct fault simulations test conventional analog fault models result addresses impractically long fault simulation time issue fully differential low pass biquad filter adopted example demonstrate design use efficient multitone tests test parameter set multitone test results acquired test procedure also reveal distortion noise performance cut though slb fault model include
paper proposes taxonomy themes research agenda sustainable infrastructure focus sustainable buildings green infrastructure citation databases web science formed basis novel strategic thematic analysis citation occurrence keywords longitudinal identification themes last two decades emerging ever growing research area multidisciplinary endeavour including diversified array disciplines general engineering environmental ecology construction architecture urban planning geography paper traces number publications growing exponentially since total citations concentrated less papers spread large number journals publications originate united states europe australia asia main research streams green infrastructure sustainable buildings assessment methods emerging prevailing research themes include methodological issues cost effectiveness project management assessment tools substantive issues complement research agenda emerging themes areas integration human economic corporate social responsibility values environmental sustainability urban landscape sustainable drainage systems interdisciplinary research green material integrated policy research urbanization agriculture nature conservation extensions green building cities developing countries elsevier ltd rights reserved
paper proposes approach using taxonomic relatedness answer type recognition type coercion question answering system introduce question analysis method lexical answer type lat semantic answer type sat describe construction taxonomy linking also analyze effectiveness type coercion based taxonomic relatedness ats compared rule based approach ibm watson lat detector combines rule based machine learning approaches achieves recall improvement without sharp decline precision sat classifier relatednessbased validation method achieves precision type coercion using taxonomic relatedness ats answer candidates construct answer type taxonomy semantic relationship two ats paper introduce link heterogeneous lexical knowledge bases propose three strategies type coercion based relatedness two ats answer candidates taxonomy finally demonstrate combination individual type coercion creates synergistic effect
paper proposes image information hiding algorithm bases hvs mbns algorithm uses characteristics human visual system hvs embedded large amounts data according different area achieve different degree embedded pixels smooth areas corresponding base small pixels complex areas corresponding base great secret information segment embedded image based modular arithmetic case study provided demonstrate fact method achieve efficient load ensure lowest rate image distortion relative standard test images
paper proposes uncertain rule based fuzzy neural system ufns stable learning mechanism nonlinear systems identification control proposed ufns system preserves ability handling uncertain information also performs less computational effort sinusoidal perturbations adopted combine fuzzy term sets ufns training ufns systems system identification control applications gradient descent method adaptive learning rate derived guarantees convergence ufns choosing adaptive learning rates enhance convergent speed provides simple way choosing learning rates training ufns also guarantees convergence faster learning finally effectiveness performance proposed approach illustrated several examples computational complexity analysis nonlinear system identification tracking control two link robot manipulator system
paper proposes tests models provide quick searching retrieval continuations longest repeated suffix data sequences particularly musical data using relational databases authors extend existing interactive music generation systems focusing large input sequences algorithms indexing prefix trees factor oracles relational databases also proposed experiments using textual musical data provide satisfactory performance results models using two indexing methods
paper proposes use autonomous assistant mobile robot order monitor environmental conditions large indoor area develop ambient intelligence application mobile robot uses single high performance embedded sensors order collect geo reference environmental information ambient temperature air velocity orientation gas concentration data collected assistant mobile robot analyzed order detect unusual measurements discrepancies develop focused corrective ambient actions paper shows example measurements performed research facility enabled detection location uncomfortable temperature profile inside office research facility ambient intelligent application developed performing localized ambient measurements analyzed order propose ambient actuations correct uncomfortable temperature profile
paper provides overview development long span bridges monitoring japan emphasis monitoring strategies types monitoring system effective utilization monitoring data severe environment condition high seismic activity strong wind bridge monitoring systems japan historically put emphasis structural evaluation extreme events monitoring data used verify design assumptions update specifications facilitate efficacy vibration control system among first objectives instrumentation long span bridges framework monitoring system japan later monitoring systems also utilized evaluate structural performance various environment loading conditions detect possible structural deterioration age structures monitoring systems also employed basis investigation decision making structural repair retrofit required recent interest extend application monitoring facilitate operation maintenance rationalization risk asset management utilizing monitoring data paper describes strategies several examples monitoring system lessons learned structural monitoring long span bridges japan
paper provides theoretical experimental investigations performance stirling generator city karaj located west tehran designed fabricated type stirling engine mounted focal point parabolic solar concentrator generate electricity site materials energy research center merc located south east city karaj engine able operate heat source source provides minimum temperature degrees therefore parabolic concentrator diameter used purpose throughout experiments maximum net electrical power obtained system calculated total efficiency solar radiation experimental area measured order program generator operate small stationary power plant site merc annual performance stirling generator evaluated using solar data collected site consecutive years typical days extracted data month years estimate average hour numbers days solar radiation sufficient enough produce electrical power stirling electrical generator
paper puts forward novel algorithm locating faults double circuit transmission lines using two end unsynchronized current measurements algorithm require line parameters radical step forward compared existing approaches require information considered settings free algorithm positive sequence current phasors fault processed determining sought distance fault synchronization angle limiting thus amount data needed transferred line terminal proposed algorithm derived applying kirchhoff voltage law around parallel circuits loops fault algorithm applicable transposed untransposed double circuit lines independent fault type evaluation studies using reliable alternative transients program electromagnetic transients program simulation data verify accuracy proposed algorithm high various fault resistances fault locations source impedances
paper raises question status building waterproofing facing technical route background significance research content research basis current problems domestic construction waterproofing industry development management analysis whole whole process building water projects form basis key factors controlling system pointed construction waterproofing quality depends quality materials design quality process quality construction technology level workers operating level product level protection construction management factors
paper reports investigation deformation response geosynthetic reinforced soil layers evaluate level strain required mobilize reinforcement mechanisms surface loading specifically assessment data previous studies reporting surface settlements reinforced unreinforced soil layers monotonic cyclic loading failure complemented new dynamic tests performed small medium strain magnitudes series test sections without geosynthetic reinforcement characterized using vibroseis shaker truck dynamic loading source behavior uniform sand layers relatively small strain magnitudes shear strain magnitudes less characterized using embedded geophones shear normal strain distributions within test sections measured function depth application surface shear loading presence geosynthetic reinforcement either geogrid geotextile depth surface sand layer significantly alter distributions shear strain vertical normal strain relative unreinforced control section magnitudes shear compressive strains applied soil surface behavior aggregate base layers overlying sand layers medium strain magnitudes surface deflections characterized using array lvdts soil surface surface deflection basins measured application several thousand cycles compressive loading presence geogrid within aggregate base layer woven geotextile beneath aggregate base layer observed lead change surface deflection basins maximum deflection observations together results literature indicate reinforcement mechanisms lateral restraint tensioned membrane effect may mobilized reaching relatively large displacements soil layers
paper reports proof concept microelectromechanical system based fabry perot filter capable electrically tuning within long wave infrared thermal imaging band device employs single layer quarter wavelength thick tensile germanium membrane suspended top mirror order achieve nanometer scale released mirror flatness across area several hundred square micrometers without extraneous stress management techniques mechanical optical characterization tunable filters various sizes presented compared dimension square filter demonstrated top mirror bowing near theoretical spectral characteristics across entire tuning range namely peak transmission full width half maximum spectral passband approximately band rejection greater optical modeling shows filter achieve pixel pixel transmission peak wavelength variation less across entire optical imaging area results exceed optical performance requirements passive multispectral thermal imaging applications based large area focal plane arrays comparison dimension filters shown exhibit significant mirror bowing actuation thus pixel pixel transmission peak wavelength non uniformity demonstrate narrower usable spectral tuning ranges respectively
paper reports feasibility preliminary effects decision aid female fertility preservation conducted pilot multicentre randomized controlled trial women breast cancer aged randomized brochures months women eligible invited healthcare provider participate study total women signed participation randomized brochures groups many women read brochures eight women used available brochures intervention group women logged women received brochures slightly less decisional conflict whereas knowledge improved groups results indicate brochures detailed beneficial effects regard knowledge seemed introduce slightly decisional conflict brochures although encountered challenges recruitment design measurements seem feasible effects information materials seem promising hence justifying conducting larger study
paper reports instrumentation monitoring fibreglass epoxy composite manufacturing process using optical fibre sensor based bragg grating sensor made superimposed long period grating lpg fibre bragg grating fbg written fibre zone sensor gives accurate results good spatial resolution due ability discriminate intrinsically thermal kinematic effects sensor initially tested curing epoxy resin alone order assess temperature strain measurements shown two factors well discriminated quantified paper presents results monitoring liquid resin infusion lri fbg lpg sensor embedded composite part dielectric analysis also performed results analyses thermal cycle curing induced residual strains discussed elsevier ltd rights reserved
paper reports systematic search review literature relating health wellbeing young children across transition school identified papers including empirical studies reviews commentaries reports relevant research questions completed interpretive systematic review ascertain current state literature review employed critical interpretive synthesis cis method allow rigorous systematic review disparate literature stretches across several disciplines findings presented seven thematic categories current conceptualisations health wellbeing assessment measurement school readiness service integration transition actors risk children child voice findings illustrate ways concepts constructed identified operationalised early years research practice policy moreover highlights known used inform review implementation services practices partnerships support child health wellbeing transition school
paper reports use robots teaching essence science technology engineering mathematics stem students first grade grade stem skills learning experience developed gradually years tested students since sample size small time span short limited statistics data available main goal paper sharing firsthand experience using set robots teach students grades paper starts general information lego mindstorms robots basic methods concept stem simple terms paper explains building programming robots implemented different ways different age experience groups groups discussion first group youngest without experience second group older without experience third group older experience fourth group group middle school age grade students mostly pre exposure robots last group consists high school students group given age appropriate goal observed different challenges conquer using lego mindstorms previous version nxt well studied hands experience building learning path students first grade grade value finally expectation education results future touched upon
paper represents exact modeling auto transformer fed high speed railroad hsr using constant current mode hsr rapidly changing single phase load feeding substation three phase electric power transformed paired directional single phase electric power train moves along section line two adjacent ats analysis catenary voltage fed hsr system quite complicated work therefore order solve complicated system paper proposes novel efficient method generalized equations catenary voltage fed hsr voltage profile entire railroad system solved regardless number position trains feeding distance substation normal extension mode case studies results proposed equation catenary voltage profile compared simulation using pscad emtdc
paper reviews recent literature mental health needs youth context war terrorism human rights lens used explore issues accessibility sustainability service utilization times crisis authors present evolution services last several decades progressing individual school based community wide interventions exploring models focus symptom reduction building resilience paper highlights benefits limitations traditional intervention methods proposes new frontier intervention development research authors focus emerging field mental health services specifically highlight utility virtual reality games treating trauma exposed youth rapid easily accessible nature mental health models presented one potential solution barriers accessibility help promote human rights youth exposed war terrorism
paper reviews recent work design experimental implementation application two fundamental optical analog signal processing functionalities namely photonic temporal differentiation photonic temporal integration using customized grating devices directly written optical fibers
paper settles conjecture gazzola pavani regarding solutions fourth order ode arises models traveling waves suspension bridges suitable assumptions nonlinearity initial data demonstrate blow finite time case first investigated gazzola also handled proof requires less differentiability approach inspired gazzola exhibits oscillatory mechanism underlying finite time blow blow nonmonotone solutions oscillating higher amplitudes shrinking time intervals context bridge dynamics phenomenon appears consequence mutually amplifying interactions vertical displacements torsional oscillations elsevier inc rights reserved
paper studies control coexisting attractors impacting system via recently developed control law based linear augmentation special attention given two control issues framework multistable engineering systems namely switching coexisting attractors without altering system main parameters avoidance grazing induced chaotic responses effectiveness proposed control scheme confirmed numerically case periodically excited soft impact oscillator analysis shows path following techniques non smooth systems used order determine optimal control parameters terms energy expenditure due control signal transient behavior control error applied broad range engineering problems elsevier rights reserved
paper studies group consensus problem networks multi agent systems nonlinear dynamics agents unknown nonidentical assume unknown dynamics linearly parameterized adaptive control method adopted algorithm design novel algorithm proposed multi agent systems reach group consensus via pinning control strategies rely relative position information neighboring agents stability parameter convergence analysis done based lyapunov theory barbalat lemma adaptive control theory algebraic graph theory finally simulation example given validate theoretical results
paper studies resource allocation algorithm design secure information renewable green energy transfer mobile receivers distributed antenna communication systems particular distributed remote radio heads rrhs antennas connected central processor via capacity limited backhaul links facilitate joint transmission rrhs equipped renewable energy harvesters share energies via lossy micropower grid improving efficiency conveying information green energy mobile receivers via radio frequency signals considered resource allocation algorithm design formulated mixed nonconvex combinatorial optimization problem taking account limited backhaul capacity quality service requirements simultaneous wireless information power transfer swipt aim minimizing total network transmit power imperfect channel state information wireless energy harvesting receivers powered wireless network available light intractability problem reformulate optimization problem binary selection facilitates design iterative resource allocation algorithm solve problem optimally using generalized bender decomposition gbd furthermore suboptimal algorithm proposed strike balance computational complexity system performance simulation results illustrate proposed gbd based algorithm obtains global optimal solution suboptimal algorithm achieves close optimal performance addition distributed antenna network swipt renewable energy sharing shown require lower transmit power compared traditional system multiple colocated antennas
paper systematically reviews literature pertaining use resting state functional magnetic resonance imaging rsfmri anorexia nervosa classifying studies basis different analysis approaches followed prisma guidelines fifteen papers included investigating total participants current past controls studies used seed based whole brain independent component analysis ica network interest ica based graph analysis approaches studies showed relatively consistent overlap results yet little overlap analytical approach priori assumptions functional connectivity alterations mainly found corticolimbic circuitry involved cognitive control visual homeostatic integration overlapping findings found brain areas putatively important insula results suggest altered functional connectivity networks areas linked main symptom domains impaired cognitive control body image disturbances preliminary evidences suggest targeted treatments need developed focus two symptom domains studies multi approach analyses longitudinal designs needed better understand complexity authors published elsevier ltd
paper uses fluid mechanics approach perform swarming aggregation quadrotor unmanned aerial vehicle quav swarm platform done adapting smoothed particle hydrodynamics sph technique algorithm benchmarking conducted see well sph performs simulations varying set ups experimented compare different algorithms sph position error sph less benchmark algorithm target enclosure introduce sph implemented using crazyflie quadrotor swarm aggregation behavior exhibited successfully said platform
paper focus concept reduce complexity connectivity integrated manufacturing engineering system using enterprise service bus esb approach software platform developed designing implementing interaction communication mutually interacting software subsystems modules manufacturing engineering systems developed approach enables manufacturing engineering systems make use comprehensive flexible consistent integration reduce complexity applications integrated main objective current study analyse esb systems integrate data activities considered products supply chain shop floor management processes
paper scope shear interaction mechanisms three critical geosynthetic interfaces geotextile geomembrane drainage geocomposite geomembrane soil geomembrane typically used lined containment facilities landfills large direct shear machine used carry geosynthetic interface tests results showed strain softening behaviour small dilatancy non linear failure envelopes normal stress range kpa three types interfaces present main interaction mechanisms interlocking friction geotextile geomembrane drainage geocomposite geomembrane interfaces higher asperity height higher interface shear strength whereas soil geomembrane interfaces higher soil shear strength higher interface shear strength drainage geocomposite geomembrane interface showed lowest friction angles followed geotextile geomembrane soil geomembrane interfaces
policy paper intends provide inputs community health program development high blood pressure hbp prevention treatment improvement latest two consecutive national health surveys revealed deviant pattern hbp among pre menopause females earlier take hbp prevalence observed females males exploration hbp risk age sex performed findings showed higher prevalence hbp risk among females age obesity emotional distress contraceptive use contribute hbp occurrence result analysis inconclusive identify precise risk earlier take high blood pressure could probably due hormonal contraceptive use higher prevalence risk among females since already higher health service utilization recommended existing non communicable diseases ncd prevention monitoring program expanded provide service young females among service provided motivation healthy diet physical activity mental health service family planning
practice parameter intended guide appropriately trained licensed physicians performing therapy unsealed radiopharmaceutical sources therapy requires close cooperation communication physicians responsible clinical management patient administer radiopharmaceutical therapy manage attendant side effects adherence practice parameter help maximize efficacious use procedures maintain safe conditions ensure compliance applicable regulations goal therapy unsealed radiopharmaceutical sources provide either cure effective palliation disease minimizing untoward side effects complications
qualitative multiple case study explored sources emotional stress experienced female zimbabwean primary heads leading socio economic disadvantaged schools masvingo district attempts alleviate challenges children disadvantaged contexts presented data generated individual semi structured interviews observations data analysed thematically elicit sources emotional labour emanated stress related cultural contextual factors study revealed despite school heads experiencing anxiety pain sorrow sympathy frustration sadness concern happy appointments leadership positions sources emotional stress related plight children stereotypical gender expectations lack parental cooperation unrealistic professional social expectations study suggests wellness recesses establishment social networks heads could share experiences professional development programmes stress management possible interventions could help heads deal stressful circumstances
research aims identify criteria sustainable design solutions meet needs muslims today theoretical framework nikos salingaros unified architectural theory design needs strategies derived islamic knowledge values identified used inform principles building typologies location movement buildings green building technologies line islamic values examples sustainability promoting policies analyzed used develop design strategies findings include theoretical model proposes essential design criteria appropriate architecture muslim world research relevant architects designing muslims duty create housing appropriate particular needs cultural context
research aims investigate whether individuals use categories objects classify cues inside bedroom find relations clusters occupants personality traits three studies conducted list significant belongings inside residents bedrooms obtained pilot study second study indicated existence two categories objects functional symbolic third study showed dimensions competence warmth proposed stereotype content model associated functional symbolic categories objects respectively authors published elsevier ltd
research characterized vibration responses cement pavement surface slabs atop different interlayers moving vehicle load via laboratory simulated vibration response tests field tests done help micro seismic monitoring system laboratory simulated vibration response tests hammer used impose impact loading geotextile rubber sheet used interlayers laboratory test results indicated impact load compared surface slabs without interlayer beneath vector sum peak vibration velocity surface slabs atop rubber sheet interlayer single layered geotextile interlayer double layered geotextile interlayer decreased respectively vector sum maximum displacement amplitude decreased respectively field tests vibration response done estimated vehicle loading rear axle loading estimated vehicle speed surface slabs geotextile plastic membrane interlayer beneath tested field test results indicated conditions compared surface slabs without interlayer beneath vector sum peak vibration velocity surface slabs atop interlayer double layered geotextile plus single layered plastic membrane interlayer single layered geotextile plus single layered plastic membrane interlayer single layered plastic membrane decreased respectively vector sum maximum displacement amplitude decreased respectively conclude rubber sheet interlayers geotextile interlayers help cement pavement surface slabs significantly damp vibrations caused moving vehicle load impact load
research described adults beliefs nicotine low nicotine cigarettes lncs using nationally representative health information national trends survey hints fda three quarters people either unsure relationship nicotine cancer incorrectly believed nicotine causes cancer people non white less educated age never established smokers likely unaware nicotine cause cancer quarter people held potentially inaccurate beliefs lncs would less harmful addictive typical cigarettes whites likely blacks believe lncs less harmful typical cigarettes never smokers likely believe established quitters whites people least college degree likely believe lncs would less addictive typical cigarettes overall found many people particularly demographic subgroups identified held incorrect beliefs nicotine potentially inaccurate beliefs lncs findings considered assessing public health impact marketing low nicotine products incorrectly believing nicotine causes cancer could discourage smokers switching safer nicotine containing alternatives could lead nonsmokers experiment low nicotine tobacco products believing cancer risk would reduced findings underscore need educate public health effects nicotine lncs help public health practitioners determine subgroups prioritized targeted educational efforts published elsevier inc
research evaluates cost efficient rainwater harvesting rwh system new commercial building located north portugal braga based economic analysis cost efficiency presented rwh strategies may considered case studied results research indicate rwh scenarios proposed cost efficient considering discount rate water price charge municipally braga cost infrastructures would enough make rwh cost efficient option discount rate payback period ranges years internal rate return would range discount rate considered payback periods would reduced approximately year
research examined perceptions public mobile phone conversations conversationalists participants viewed staged video public conversation later rated perceptions conversation target speaker two variables manipulated whether conversation took place mobile phone face face whether participants could hear sides one side conversation general participants rated one side mobile phone conversation noticeable intrusive annoying conditions additionally target speaker condition less well liked speaker conditions perceptions target extraversion varied function whether conversation occurred mobile phone overall results suggest existence negative views toward mobile phones exposure one side conversation elsevier ltd rights reserved
research explored competing predictions relation uncertainty interpersonal attraction two studies investigated whether uncertainty regarding another person interest associated increase decrease attraction study revealed participants evaluated people whose expressed attraction either certain uncertain participants experienced liking associated certainty study compared control condition uncertainty produced attraction greater attraction mediated desire reduce uncertainty conclude proposing explanation different research paradigms produced different conclusions regarding uncertainty situations necessary uncertainty produce interpersonal attraction
research handles proposed technology defense security system anti stealth technology technology supposes increasing radar cross section rcs stealth system increasing relative permittivity epsilon decreasing attenuation epsilon consequently loss tangent tan delta non lethal pulsed yag laser proposed solution enhancing stealth wave absorber relative permittivity research handles probabilistic algorithm detecting stealth target using neural network future implementation anti stealth technology
research investigated behavioural consequences homophobic epithets exposure either category homophobic label heterosexual participants allocated fictitious resources two different prevention programmes one mainly relevant heterosexuals sterility prevention homosexuals aids hiv prevention responses allocation matrices served identify strategies favoured ingroup outgroup results indicated stronger ingroup favouritism homophobic category label condition study shows discriminatory group labels tangible effects people monetary behaviours intergroup contexts increasing tendency favour ingroup distributing resources
research investigated relationship among perception ingroup threats realistic symbolic conservative ideologies social dominance orientation sdo right wing authoritarianism rwa prejudice immigrants data collected cross sectional design two samples non student italian adults healthcare professionals results similar samples indicated symbolic realistic threats well sdo rwa positively significantly predicted anti immigrant prejudice moreover model considering sdo rwa mediators threats effects prejudice showed better fit model ingroup threats mediated effects sdo rwa prejudice immigrants accordingly sdo rwa partially mediated effect symbolic realistic threats maintained significant effect prejudice immigrants however
research investigated relationship false memories induced two different paradigms misinformation deese roediger mcdermott drm misinformation effect refers phenomenon person recollection witnessed event altered exposure misleading information event drm false memory represents intrusion words semantically related actually presented study session subjects completed misinformation drm false memory tests results showed small significant correlation misinformation drm false memories furthermore using signal detection theory found discrimination ability index related misinformation drm false memories response bias related drm false memory results suggest misinformation drm false memories generally involve different mechanisms shared mechanism may involve global discrimination ability
research investigates influence religious preference practice use contraception much earlier research examines level religiosity sexual activity research extends reasoning suggesting peer group effects create willingness mask level sexuality use contraception understood certain religions catholicism condone use contraceptives research finds catholics likely use certain methods contraception religious groups data contraceptive use center disease control family growth survey likelihood probability model employed investigate impact religious affiliation contraception use findings suggest preference methods ensure non pregnancy preventing feelings shame condemnation religious communities
research presents study design constructionof afertilizer rotary dryerin pig farm usedwaste heat degree celsius electrical generator designed rotary dryer consisted two pipes lengths meters pipes consisted drying cooling pipe diameter meter power supplied two horse power motors horse power blowers used suck hot cool air drying fertilizer initial moisture content examined three parameters varied study optimal condition drying rotary speed degree tilt angle air flow rate rotary speed varied rpm degree tilt angle set degrees air flow rate varied cubic meters per hour experiment result revealed condition degree tilt angle rpm rotary speed air flow rate cubic meters per hours optimal conditions drying fertilizer moisturein fertilizer reduced dbto drying rate thermal efficiency energy consumption kwh ton capacity designed rotary dryer tons day three times amount traditional drying method cost rotary dryer baht payback period months
research suggests maximum power point tracking mppt solar photovoltaic power scheme using new constant voltage fractional order incremental conductance foinc algorithm panel low transformation efficiency power output panel depends change weather conditions possible extracting power raised battery load utilizing mppt algorithm among mppt strategies incremental conductance inc algorithm mostly employed due easy implementation less fluctuations faster tracking merits inc fractional order deliver dynamic mathematical modelling define non linear physiognomies foinc variation dynamic variable exploited regulate power toward peak operating point lesser scale photovoltaic conversion scheme suggested technique validated simulation dissimilar operating conditions contributions made numerous aspects entire system including new control algorithm design system simulation converter design programming simulation environment experimental setup results confirm small tracking period practicality tracking photovoltaic array
research work deals landslide susceptibility assessment using analytic hierarchy process ahp information value methods along highway road section constantine region algeria landslide inventory map total single landslide locations created based historical information aerial photo interpretation remote sensing images extensive field surveys different landslide influencing geoenvironmental factors considered study lithology slope gradient slope aspect distance faults land use distance streams geotechnical parameters thematic layer map generated every geoenvironmental factor using geographic information system gis lithological units distance faults maps extracted geological database region slope gradient slope aspect distance streams calculated digital elevation model dem contemporary land use map derived satellite images field study concerning geotechnical parameters maps determined making use geotechnical data laboratory tests analysis relationships landslide related factors landslide events carried gis environment auc plot showed susceptibility maps success rate ahp models respectively purpose model better predicting occurrence landslides ahp one therefore information value method could used landslide susceptibility mapping zonation method along sections highway
review aims present different effects produced post weaning intake limitation strategy growing rabbit largely used french professional rabbit breeders although quantitative feed restriction leads slower growth feed conversion improved particularly rabbits fed freely compensatory growth occurs better healthy rabbit better digestion resulting slower passage intestine whereas digestive physiology slightly modified morphometry intestinal mucosa fermentation pattern microbiota meat quality carcass characteristics greatly affected feed restriction except lower dressing percentage one main advantages limiting post weaning intake rabbit reduce mortality morbidity rate due digestive disorders particularly epizootic rabbit enteropathy syndrome consequences animal welfare debatable feed restriction probably leads hunger reduces incidence digestive troubles weaning however growing rabbit adapts well intake limitation strategy without aggressive behaviour congener conclusion restriction strategies could improve profitability rabbit breeding adapted specific breeding situation according national market feed prices etc
review describes evolving role oral hormone therapy treating menopausal symptoms preventing osteoporosis focusing conjugated estrogens bazedoxifene bza estrogens alleviate hot flushes prevent bone loss associated menopause nonhysterectomized women progestin added estrogens reduce risk endometrial cancer use declined since women health initiative whi studies showed prevent coronary heart disease chd conjugated estrogens medroxyprogesterone acetate increased risk invasive breast cancer nearly years use however analyses whi data suggest risks chd cause mortality may reduced initiated women years age years since menopause compared later bza first menopausal without progestogen nonhysterectomized women instead bza selective estrogen receptor modulator combination protects estrogenic effects uterine breast tissue data large randomized clinical trials show bza reduces hot flush frequency severity prevents bone loss reduces bone turnover improves vaginal maturation index ease lubrication improves measures sleep menopause specific quality life studies years increase endometrial hyperplasia vaginal bleeding breast density breast pain tenderness compared placebo venous thromboembolism stroke risks estrogen based therapies choice individualized consideration risk benefit profile tolerability therapy well patient preferences
review explores past two decades research ancient maya skeletons focus work contributed understanding health diet social change inequality migration mobility war violence ritual practice special attention given recent methodological developments debates bioarchaeology maya review essay highlights recent findings bioarchaeology maya results achieved essay concludes suggestions future research highlights areas potential collaboration underutilized address broader anthropological questions
review empirical research effects media violence examines learned evidence extent evidence accepted face value article reexamines debates different data types different methodologies theoretical explanatory models directions effect value aggregated data sets limitations weaknesses identified relation various methodological approaches sources evidence featured academic discussions debates media policy content regulation although dismissing empirical research subject valueless critique advises caution accepting blanket conclusions harmful effects media violence instead calling targeted approach recognizes media consumers may susceptible others media effects media depictions violence vary risks represent potential triggers unpleasant harmful reactions among media consumers
review presents date understanding immunotherapy treatment children allergic asthma principal types allergen immunotherapy ait subcutaneous immunotherapy scit sublingual immunotherapy slit indicated patients allergic rhinitis asthma evidence clinically relevant allergen specific ige significant symptoms despite reasonable avoidance measures maximal medical therapy studies shown significant decrease asthma symptom scores use rescue medication preventive effect asthma onset although safety profile slit appears better scit results studies meta analyses suggest efficacy scit better scit earlier onset slit children allergic asthma severe controlled asthma medical error frequent causes scit induced adverse events
review reports beneficial pharmacological properties naturally occurring polyphenols treatment inflammatory pulmonary diseases addition presents overview different types inhalable formulations developed order achieve efficient delivery polyphenols respiratory tract main biological activities polyphenols anti oxidant anti inflammatory covered particular emphasis studies describing therapeutic effects different factors conditions characteristic lung pathologies special focus technological aspects influence pulmonary delivery drugs various polyphenol based inhalable formulations reported literature examined specific attention preparation methodologies aerosol performance lung deposition vitro vivo polyphenol uptake pulmonary epithelial cells
special issue aims gaining deeper understanding relationship underlying structural order resulting physical properties aperiodic systems including quasicrystalline related complex metallic alloys photonic quasicrystals structures exhibiting long range aperiodic order special issue contains papers highlight recent developments quasiperiodic crystal structure photonic quasicrystals related optical devices intrinsic electrical thermal mechanical properties icosahedral decagonal metallic alloys nature chemical bonding intermetallic compounds multidisciplinary perspective light results presented contributions collected special issue confidently expect new insights interdisciplinary science quasicrystals gained years come providing sharper picture structures related physical properties spurring progress practical issues related materials engineering science nanotechnology
study addresses topic previously unaddressed literature normal sonographic appearance hoffa fat pad hfp young asymptomatic subjects aim study describe sonoanatomical features hfp including echostructure echogenicity elasticity vascularization subjects without knee pathology knees healthy subjects examined grayscale ultrasound determine sonographic characteristics hfp echogenicity assessed pixel intensity quantification vascularity evaluated color doppler elasticity adipose tissue examined sonoelastography absence hfp pathology confirmed clinically participants magnetic resonance imaging randomly selected participants seventy two knees subjects assessed hfp presented characteristic well defined two layered echostructure superficial adipose tissue hypoechoic respect nearby patellar tendon contained septae whereas deeper layer homogeneously hypoechoic lacked connective tissue septae echogenicity differed superficial deeper layers deeper layer brighter suggesting degree acoustic impedance differed layers detected blood flow hfps superficial hfp layer presented greater elasticity deeper hfp layer kpa study provides comprehensive description normal sonographic features hfp useful increase potential discrimination pathological findings involving anatomical area
study addresses relationship various family forms level cognitive non cognitive skills among year old students measure cognitive skills using standardized scores mathematics non cognitive abilities captured composite measure internal locus control related mathematics particular focus lies father absence although also examine role played residence siblings grandparents use cross nationally comparable data students participating programme international student assessment release mapping inequalities family forms across developed countries study provides robust cross country comparable evidence relationship household structure cognitive non cognitive skills study produces three key results first absence fathers household well residence grandparents associated adverse outcomes children virtually developed countries second generally true terms cognitive non cognitive skills although disadvantage connected family forms notably stronger former latter domain finally marked cross national diversity effects associated presence household siblings especially grandparents furthermore differs across two outcomes considered
study adopted two author algorithm journalist two notification author real inverse subject design investigate public journalists perceive quality algorithms written articles compared human journalist work findings showed public journalists evaluations varied manipulation author notification public gave higher scores algorithm work notified real author gave lower scores algorithm work author notified journalist confirmed public negative attitude toward journalists credibility craving new information communication technology ict products services korea based journalists resistance change innovation theory prejudice expected journalists would favorable another journalist work unfavorable algorithm work however contrary hypothetical expectation journalists also gave higher scores algorithm work lower scores journalist work implications relating intrusion algorithm written articles journalism discussed elsevier ltd rights reserved
study adopts rainwater harvesting systems rwhs stormwater runoff management model swmm spatial design capacities quantities rain barrel urban flood mitigation simulation optimization model proposed effectively identifying optimal design first particularly classified characteristic zonal subregions spatial design using fuzzy means clustering investigated data urban roof land use drainage system simulation method series regular spatial arrangements specification designed using statistical quartiles analysis rooftop area rainfall frequency analysis accordingly corresponding reduced flooding circumstances simulated swmm moreover effective solution simulation method identified calculated net benefit equivalent subtraction facility cost decreased inundation loss serves initially identified solution optimization model optimization method backpropagation neural network bpnn first applied developing water level simulation model urban drainage systems substitute swmm conform newly considered interdisciplinary multi objective optimization model tabu search based algorithm used embedded bpnn based swmm optimize planning solution developed method applied zhong district taiwan results demonstrate application tabu search bpnn based simulation model optimization model effectively accurately fast search optimal design considering economic net benefit furthermore optimized spatial rain barrel design could reduce inundation losses according simulated flood events
study aimed characterizing fatty acid composition red blood cell rbc phospholipids children adolescents primary hyperlipidemia ascertain potential association serum lipid profile dietary factors purpose probands aged years recruited subjects showed low omega index eicosapentaenoic acid epa docosahexaenoic acid dha compared males females trend toward lower levels total monounsaturated fatty acids mufa mufa saturated fatty acids sfas ratio rbcs inverse relationship mufa concentration rbcs serum cholesterol hdl triglycerides ratio found omega polyunsaturated fatty acids pufa positively associated serum hdl levels inversely dietary cholesterol fiber intake positively associated mufa sfa ratio conclusion provide first experimental data phospholipid composition rbcs hyperlipidemic children showing sex differences overall low omega index
study aimed analyze level knowledge concerning emergency contraception among adolescents public private high schools cross sectional study students years age enrolled public private high schools municipality sao paulo state brazil authors used stratified probabilistic sampling type school systematic sampling class sexual initiation use emergency contraception reported private school students public school students mean score knowledge public schools private schools multiple linear regression analysis showed higher scores knowledge concerning emergency contraception associated enrollment private schools female gender older adolescents sexual initiation previous use emergency contraception knowing someone used method study concludes adolescents properly informed method many harbor persistent misconceptions
study aimed describe injury illness rates ultratrail runners competing race build foundation injury prevention help race organizers plan medical provision events prospectively transcribed medical records analysed athletes end race number injuries illnesses per runners per run overall injury illness rate confidence intervals rates major minor illnesses musculoskeletal injuries skin disorders analysed total injuries illnesses encountered race overall injuries illnesses per runner per run medical illnesses prominent medical diagnoses encountered followed musculoskeletal injuries skin related disorders despite ultra long nature race majority injuries illnesses minor nature medical staff runners prepare treat types injuries illnesses especially fatigue arising throughout course ultratrail run injuries lower limbs future studies attempt systematically identify injury locations mechanisms order better direct injury prevention strategies plan accurate medical care
study aimed determine relationship noninvasive measures arterial health estimated year cardiovascular risk measures disease activity time established rheumatoid arthritis fifty rheumatoid arthritis patients underwent noninvasive arterial health testing brachial artery reactivity aortic augmentation index aix pulse wave velocity carotid artery intima media thickness carotid artery plaque presence assessment clinical disease activity tender swollen joint counts clinical disease activity index cdai health assessment questionnaire haq clinical measures years study visit averaged arterial health testing compared american heart association american college cardiology aha acc pooled cohort equation spearman methods identified correlations disease activity measures cardiac biomarkers arterial health parameters among patients mean age years disease activity moderate mean cdai study visit corrected aortic augmentation index correlated cdai haq aix correlated time averaged tender joint count cdai haq swollen joint count patient global assessment physician global assessment pain score aha acc low risk group year risk highest prevalence carotid plaques arterial health testing may identify increased risk cardiovascular disease compared risk obtained aha acc pooled cohort equation measures arterial stiffness correlate burden disease activity time
study aimed determine whether markers assimilation problematic experiences dementia scale maped used identify whether way participants talk dementia changed group eight sessions livdem group attended participants recorded transcribed initial analysis identified extracts rated using maped system inter rater reliability following resolution meeting extracts discarded leaving extracts agreed marker code participants identified producing speech marker relating dementia varied warding problem solution examples markers provided proportion emergence markers indicating initial stages assimilation compared later markers changed significantly first four sessions final sessions difference still significant even markers produced verbal participant graham excluded use process measures within psychotherapy complements conventional outcome measures theoretical clinical implications
study aimed evaluate various metabolic parameters patients spinal bulbar muscular atrophy sbma investigate association indices disease severity explore underlying molecular pathogenesis compared degree obesity metabolic parameters blood pressure genetically confirmed sbma patients age sex matched healthy control sbma patients investigated correlation factors motor functional indices sbma patients lower body mass index blood glucose hemoglobin higher blood pressure homeostasis model assessment insulin resistance homa marker insulin resistance total cholesterol adiponectin levels control subjects differences visceral fat areas high density lipoprotein cholesterol hdl triglyceride levels two groups revised amyotrophic lateral sclerosis functional rating scale alsfrs correlated positively hdl negatively homa stepwise multiple regression analysis identified homa significant metabolic determinant alsfrs biochemical analysis found decreased expressions insulin receptors insulin receptor substrate insulin receptor beta autopsied muscles fibroblasts sbma patients study demonstrates sbma patients insulin resistance associated disease severity expressions insulin receptors attenuated skeletal muscle sbma providing possible pathomechanism metabolic alterations findings suggested insulin resistance metabolic index reflecting disease severity pathogenesis well potential therapeutic target sbma
study aimed identify cues upon athletes rely developing expectations regard competence sports officials examine sources information given priority different kinds sport team racquet fighting sports questionnaire athlete perception sports officials questionnaire apso developed athletes asked indicate influence cues impressions sports officials exploratory factor analysis efa yielded four factor model static cues psychological communicational performance cues athletes mostly rely psychological personal communication attributes evaluating officiating competence moreover team players perceived static cues influential forming expectations sports officials racquet players fighting contestants findings may implications athlete official relationships training sports officials
study aimed investigate associations oxytocin receptor gene oxt polymorphisms interaction maternal care gxe behaviours community sample studied women avon longitudinal study parents children alspac participated two phase prevalence study lifetime genotype data genotype associated binge eating purging genotype restrictive eating lifetime addition genotype interacted poor maternal care increase odds binge eating purging odds ratio confidence intervals study replicates previous findings association oxt polymorphisms first show interaction oxt genotype poor maternal care findings highlight important role oxytocin understanding pathophysiology authors european eating disorders review published eating disorders association john wiley sons ltd
study aimed perform overview ultrasound used implemented applied rheumatologic centers latin america retrospective multicenter year experience study undertaken eighteen centers eight countries involved following information collected demographic data indication perform examination physician required examination anatomical region required examination total patients underwent examination request examinations came frequently institution external referral services frequently requested examination rheumatology followed orthopedic rehabilitation frequently scanned area shoulder cases followed hand knee ankle wrist osteoarthritis common disease assessed patients followed rheumatoid arthritis patients psoriatic arthritis patients painful shoulder syndrome connective tissue disorders systemic sclerosis polymyositis dermatomyositis sjogren syndrome systemic lupus erythematosus evaluation frequently requested diagnostic purposes compared follow studies research protocols invasive guided procedures registered increasing applications rheumatology highlighted positive impact daily clinical practice increases accuracy musculoskeletal clinical examination influence diagnosis disease management
study aims analyze perception managers councils municipal health secretariats cosems contributions health regionalization process conducted thorough interviews presidents cosems states mato grosso sul parana ceara tocantins minas gerais data analyzed iramuteq software generated dendrogram three themes first thematic axis prominent role cosems regional governance process includes class cosems leadership process regionalization class strategic experience regional agreement process second thematic axis includes challenges provision health care regions consisting class shows meet community needs class shows local support carried cosems teams third thematic axis consists class describes operational aspects provision health care region cosems play important role regionalization process especially organic performance leadership organic performance areas ensured legitimacy leadership daily construction ensures advancement collaborative governance health regions
study aims assess risk factors cardiovascular disease cvd determine association traditional biologic disease modifying anti rheumatic drugs dmards risk cvd chinese rheumatoid arthritis patients cross sectional cohort patients hospitals around china established medical history cvd documented patients social background clinical manifestations comorbidities medications also collected patients cvd incidence compared non cvd controls patients cvd significantly advanced age long standing median disease duration often male deformity joints patients cvd also higher rates smoking rheumatoid nodules interstitial lung disease anemia prevalence comorbidities including hypothyroidism diabetes mellitus hypertension hyperlipidemia also significant higher cvd group contrast patients treated methotrexate hydroxychloroquine hcq tnf blockers lower incidence cvd multivariate analysis showed use hcq protective factor cvd hypertension hyperlipidemia interstitial lung disease independent risk factors cvd study shows independent risk factors cvd include hypertension hyperlipidemia interstitial lung disease hcq reduces risk cvd patients
study aims evaluate effectiveness online project based collaborative learning opbcl model enhancing students soft skills study involves qualitative quantitative methods using quasiexperimental designed involves respondents malaysian polytechnic pre post test non equivalent control group design used study respondents divided three groups called control treatment treatment group soft skills assessed comparison traditional project based learning method control online project based learning using cidos platform treatment online project based learning using opbcl platform treatment study opbcl prototype developed based proposed model effectiveness opbcl prototype assessed using pre post soft skills test sst collected data analysed using spss software inferential analysis intended test type non parametric kruskal wallis mann whitney wilcoxon sign rank test findings pre post soft skill indicated groups positive effects soft skills students terms successful group results showed treatment success control group followed treatment group addition analysing pre post soft skills test critical thinking problem solving ctps collaboration communication skills showed ctsp skill treatment success control group followed treatment group meanwhile skill significant difference treatment treatment group however treatment groups success control group skill significant difference control treatment group however control treatment groups success treatment group conclusion study able provide evidence students soft skills enhanced via opbcl model authors published iase
study aims evaluate effects treatment ifn beta alpha expressions nlrp nlrp nlrc aim inflammasomes caspase beta downstream molecules inflammasomes population iranian multiple sclerosis patients study patients women men participated receiving medication months treatment standard doses ifn beta alpha mcg injected intramuscularly week blood samples taken leukocytes isolated total rnas extracted complementary dnas cdnas synthesized gene expressions nlrp nlrp nlrc aim asc evaluated messenger rna mrna levels using real time pcr method assessing caspase protein level western blot method used amounts beta measured plasma using enzyme linked immunosorbent assay method analysis results therapy ifn beta alpha patients shows significantly decreased expressions nlrp nlrc aim plasma levels beta treatment ifn beta alpha significantly decreased patients based results appears nlrp nlrc aim play critical roles progression probably mediating responses seems decreased expression beta related decreased production also functions inflammasomes
study aims explore clinical characteristics risk factors rheumatoid arthritis associated interstitial lung disease ild retrospective study patients patients underwent chest high resolution computed tomography hrct scanning two hundred thirty seven five hundred fifty patients diagnose ild ild occurred onset ild occurred within years onset ild occurred years onset common chest characteristics ild included reticular patterns pleural thickening ground glass attenuation followed interlobular septum thickening nodules emphysematous bullae honeycombing bronchiectasis proportion uip pattern nsip hrct ild often associated lung lesions including pleural disease bronchiectasis pulmonary hypertension comparisons ild without ild showed male smoking age disease duration number swelling joints globulin levels erythrocyte sedimentation rate reactive protein levels lactate dehydrogenase positive rate rheumatoid factor absolute value forced vital capacity forced expiratory volume carbon monoxide diffusion rate statistically different logistic regression analysis showed age smoking elevated lactate dehydrogenase positive closely correlated ild ild occurs often within years onset coexists lung lesions elevated lactate dehydrogenase positive smoking advanced age closely correlated ild
study aims explore potential impairment theory mind tom ability represent cognitive affective mental states self others clinical neuropsychological quality life qol correlates cognitive abnormalities early stages amyotrophic lateral sclerosis als multisystem neurodegenerative disease recently recognized part clinical pathological spectrum frontotemporal lobar degeneration twenty two consecutive cognitively intact als patients healthy controls underwent assessment executive verbal comprehension visuospatial behavioral qol measures well tom abilities emotion attribution task eat advanced test tom att eyes task als patients obtained significantly lower scores controls eat significant difference found two groups att regard type als onset patients bulbar onset performed worse spinal onset correlation analysis revealed eat positively correlated education memory prose visuo spatial performances mental health scores among qol items results suggest cognitive also affective subcomponents tom may impaired early stages als significant linkage disease onset dysfunctions less executively demanding conditions causing potential impact patients mental health
study aims find effect computer based teaching activities academic achievement retention technical programme students computer programming vocational foreign language computer technologies department study conducted vocational school technical science suleyman demirel university students computer programming experimental group students taught computer assisted instructional software control group students taught traditional methods achievement test developed measure success second class students vocational foreign language lesson used pretest posttest retention test consequence seemed application computer assisted instructional methods used vocational foreign language lesson effective traditional instructional methods terms students academic achievement retention published elsevier ltd
study aims investigate dna methylation signatures fibroblast like synoviocytes fls patients rheumatoid arthritis explore relationship transcription factors tfs help distinguish osteoarthritis microarray dataset gse including six fls samples patients five fls samples patients downloaded gene expression omnibus database samples screened differentially methylated loci dmls corresponding differentially methylated genes dmgs identified followed kyoto encyclopedia genes genomes kegg pathway gene ontology enrichment analysis transcriptional regulatory network built tfs corresponding dmgs overall hypomethylated loci hypermethylated loci screened genes containing hypermethylated loci enriched pathways cancer ecm receptor interaction focal adhesion neurotrophin signaling pathways genes containing hypomethylated loci enriched neurotrophin signaling pathway moreover found ccctc binding factor ctcf yin yang myc avian myelocytomatosis viral oncogene homolog myc early growth response egr important tfs transcriptional regulatory network therefore dmgs might participate neurotrophin signaling pathway pathways cancer ecm receptor interaction focal adhesion pathways furthermore ctcf myc egr may play important roles regulating dmgs elsevier rights reserved
study analyses effect different flow rates degradation behaviour porous magnesium bone scaffold applications simulated boundary bone marrow movement induced various physiological activities considered variation flow rate experimental process also known dynamic immersion test three types porous magnesium immersed simulated body fluid sbf results show relative weight loss mechanical properties porous magnesium significantly degraded respectively increasing flow rates together increase immersion period porosity elsevier ltd rights reserved
study applied different concentration nano solution simulate effect inorganic nitrogen deposition pollution carbon storage coastal mangrove sediment observing changes enzyme activity microbial abundance sediment collected mangrove forest intertidal zone incubated different rates control low high dry sediment respectively incubation activities phenol oxidase pho acid phosphatase acp enhanced beta glucosidase glu beta acetyl glucosaminidase nag activities reduced addition altered enzymatic stoichiometries input implied microbial phosphorus limitation increased whereas limitation alleviated besides input decreased bacterial abundance increased fungal abundance types sediment increased soluble phenolics along exacerbated limitation addition might explain changes furthermore sediment addition except high treated sediment showed trend sequestration might largely caused decrease bacterial abundance glu activity however sediment high suggested trend loss possible reason discrepancy might relatively higher increase pho acp activity better understand influence deposition pollution cycling long term effect microorganisms enzymes thus storage paid attention future elsevier ltd rights reserved
study attempts investigate connection personal value profile different groups hospitality employees restaurant managers chefs cooks waiters bartenders kitchen helpers magnitude authority responsibility theit positions using analytical aspect schwartz theory basic human values basis set logistic regression models created provide support hypotheses related jobs self transcendence self enhancement axis openness change conservation axis schwartz theory basic human values achieve objectives study findings generally supported hypothesized relationships personal values professional status hospitality employees distinct relationships manifested jobs higher professional status restaurant managers chefs cooks study aims expand existing literature exploring human values hospitality sector elsevier ltd rights reserved
study compares views unaccompanied minors living four different types care facilities netherlands namely foster care small living units children living groups campuses wellbeing living circumstances place dutch society interviews minors qualitatively quantitatively analysed based transcripts interviews researchers completed questionnaire bic judge quality child rearing environment different types care facilities minors foster care fare best positive place dutch society minors small living units small living groups often miss affectionate bonds care support stability lives minors campuses often expressed feeling lonely sad excluded dutch society experience lack care support adults quality child rearing environment campuses judged researchers low facilities appear unfit unaccompanied minors
study conducted cfd coupled analysis suspension bridge subjected wind loads previous studies found rotational oscillation due differences restoring force hanger cables could generate torsional oscillations however due uncertain external force terms previous studies could applied analyze actual structures enable application real design process study proposed methodology determining external force terms external force terms determined cfd moment force term added equations motion derived dynamic equilibrium conditions constants properties calculated assumed cross section superstructure methodology used avoid torsional resonance also preliminary analysis bridge design stage
study demonstrates new method rapid precise maximum power point tracking photovoltaic applications using dithered pwm control constraints imposed efficiency cost component size limit available pwm resolution power converter may turn limit mpp tracking efficiency system scenarios pwm dithering used improve average pwm resolution study present control technique uses ripple correlation control rcc dithering ripple thereby achieving simultaneous fast tracking speed high tracking accuracy moreover proposed method solves practical challenges date limited effectiveness rcc solar applications present theoretical derivation principles behind dithering digital ripple correlation control well experimental results show excellent tracking speed accuracy basic hardware requirements
study determined interactive augmented reality context vivid memories substantially influence four types online exploratory consumption behavior concentration exploratory consumption behavior playfulness time distortion based script theory addition study indicates interactive augmented reality context consumers sense ownership control autotelic need touch significantly influence relationship vivid memories four types exploratory consumption behavior based self referencing theory results study assist online vendors using augmented reality interactive technology establishing consumer persuasion models
study discusses aspects doctor patient communication presents preliminary analysis doctor patient interactions italy aim gain information mis communication doctors patients may affect doctor patient relationship may lead patients lack trust doctors authors use corpus existing audio video materials italian doctor patient interactions analyse doctors use verbal nonverbal expressions exchanges patients analysis aimed identify features may engender communication problems leading misunderstandings perception doctors distant unreliable preliminary findings reveal patients lack trust doctors may also result doctors use culture specific patterns verbal nonverbal expressions example certain sentences used minimizing patients fears specific postures gestures signalling distance closure findings used planning future investigations doctor patient interactions based collection analysis audio visual material detailed knowledge patterns mostly affect communication natural settings provide important information implemented digital devices
study discusses relations life stories political narratives attitudes towards social problems taken local leaders living poor underprivileged suburb using biographical narrative method addresses questionshow local conditions terms housing social class municipal policy social networks ngo settings local conflicts organizational narratives etc affect local leaders narratives biographies attitudes strategies vice versahow narratives affect urban order order attain answers paper presents two contradicting narratives taken two different local activists acting behalf weak arab population israeli suburb turn century findings show divergent narratives resultant attitudes deeply rooted narrator life story close social milieu furthermore life stories charged certain biographical resources generated maintained particular strategies turn affected reconstruction immediate urban socio political order applying biographical narrative method urban political realm created unique configuration social analysis policy implications especially regard community social work
study evaluated effects inhalation lavender essential oil vital signs open heart surgery icu main complaint patients open heart surgery dysrhythmia tachycardia hypertension due stress pain due side effects chemical drugs opioids use non invasive methods aromatherapy relieving stress pain parallel chemical agents could important way decrease dose side effects analgesics multicenter single blind trial patients open heart surgery recruited inclusion criteria full consciousness lack hemorrhage heart rate beats min systolic blood pressure mmhg diastolic blood pressure mmhg using beta blockers operating room icu history addiction opioids use analgesics regular spontaneous breathing ability receiving synthetic opioids within extubation ten minutes extubation patients vital signs including central venous pressure cvp spo measured cotton swab impregnated drops lavender essential oil placed patients oxygen mask patients breathed min thirty minutes aromatherapy vital signs measured main objective study change vital sign aromatherapy statistical significance accepted significant difference systolic blood pressure diastolic blood pressure heart rate intervention using paired test although results show significant difference respiratory rate spo cvp inhaling lavender essential oil therefore aromatherapy could effectively reduce blood pressure heart rate patients admitted open heart surgery icu used independent nursing intervention stabilizing mentioned vital signs limitations study sample size lack control group randomized clinical trials larger sample size recommended
study evaluates unbranched saturated carboxylic esters respect suitability used storage media latent heat storage applications therefore important thermophysical properties gathered means literature research well experimental measurements additionally esters critically evaluated common phase change materials terms environmental impact economic potential experimental investigations performed eleven selected ester samples focus determination melting temperature enthalpy fusion using differential scanning calorimetry transient hot bridge used determine thermal conductivity liquid samples thermogravimetric analysis employed evaluation weight loss temperature well decomposition temperature nonvolatile samples experimental results literature data reveal highest potential esters phase change materials lies low temperature applications main alternative using salt hydrates elsevier ltd rights reserved
study examined associations among family level risks emotional climate child adjustment families experiencing homelessness emotional climate indirect aspect emotion socialization indexed parents expressed emotion describing children sociodemographic risk parent internalizing distress hypothesized predict negativity less warmth emotional climate emotional climate expected predict observer rated child affect teacher reported socioemotional adjustment mediating effects risk participants homeless parents percent african american four six year old children percent male semi structured interviews parents reported demographic risks internalizing distress completed five minute speech sample child later rated warmth negativity children positive negative affect coded videotapes structured parent child interaction tasks socioemotional adjustment externalizing behavior peer acceptance prosocial behavior reported teachers months later hypotheses partially supported parent internalizing distress associated higher parent negativity linked negative affect children parent warmth associated children positive affect neither emotional climate child affect predicted teacher reported externalizing behavior peer acceptance parental negativity male sex predicted lower prosocial behavior classroom future research directions clinical implications discussed
study examined gender age task differences positive touch physical proximity mother child father child conversations sixty five spanish mothers fathers months year old months children participated study positive touch examined play related storytelling task reminiscence task conversation past emotions fathers touched children positively frequently play related storytelling task mothers mothers fathers closer proximity year olds year olds mothers fathers touched children positively frequently reminiscing playing finally year olds remained closer parents year olds implications findings future research children socioemotional development discussed
study examined effects exposure specific message features usage mental health video games applications based linguistic agency disease causality participants mild depression read messages assigning agency depression humans depicting depression external internal accessing video game designed handling depression symptoms assigning internal causality language led greater game usability higher intentions using games game performance time spent playing games higher external causality language overall findings study demonstrate effectiveness specific message prompt features promote video game experience mental health apps elsevier ltd rights reserved
study examined effects weather personality self ratings single assessment data derived german general social survey conducted subset participants official weather station data day personality inventory completed could determined among respondents completed personality inventory unambiguously sunny day completed measure unambiguously rainy day completed questionnaire day characterized mixed weather conditions results revealed self ratings personality domains differed depending weather conditions day inventory completed compared corresponding self ratings collected mixed weather conditions ratings big five dimension openness experience significantly lower rainy days ratings conscientiousness significantly lower sunny days results suggestive limitations assumed situational independence trait ratings
study examined extent positive negative parenting relates conduct problems callous unemotional traits among adolescents males age years attention deficit hyperactivity disorder whether traits moderate link parenting mothers reported adolescents traits parenting practices maternal behaviors observed problem solving communication task parents engaged positive parenting self reported observed reported adolescents lower levels traits effect found negative parenting moderation analyses indicated lower levels positive maternal behavior associated higher presence higher levels traits negative parenting positively related regardless traits positive parenting irrespective measurement approach uniquely relates adolescents traits positive negative parenting relate
study examined influence model minority stereotype perceived mental health functioning asian americans hypothesized college students would perceive asian americans fewer mental health problems clinical symptoms whites due model minority stereotype four hundred twenty five undergraduate students predominately white college campus american northeast randomly exposed one four conditions clinical vignette describing white college student suffering adjustment disorder vignette describing asian american college student newspaper article describing success story whites white clinical vignette newspaper article clinical vignette describing asian american following exposure one conditions participants completed memory recall task measures colorblindness attitudes towards asian americans attitudes towards group members perceived mental health functioning participants exposed vignettes primed positive model minority stereotype perceived target regardless race ethnicity better mental health functioning less clinical symptoms condition without stereotype additionally stereotype primer found modest predictor perception mental health functioning asian american vignettes results shed light impact model minority stereotype misperception asian americans mental health status contributing invisibility neglect minority group mental health needs
study examined links desensitization violent media stimuli habitual media violence exposure predictor aggressive cognitions behavior outcome variables two weeks completing measures habitual media violence exposure trait aggression trait arousability normative beliefs aggression undergraduates saw violent film clip sad funny comparison clip skin conductance level scl measured continuously ratings anxious pleasant arousal obtained clip following clips participants completed lexical decision task measure accessibility aggressive cognitions competitive reaction time task measure aggressive behavior habitual media violence exposure correlated negatively scl violent clips positively pleasant arousal response times aggressive words trait aggression unrelated anxious arousal aggressive responding reaction time task path analyses controlling trait aggression normative beliefs trait arousability habitual media violence exposure predicted faster accessibility aggressive cognitions partly mediated higher pleasant arousal unprovoked aggression reaction time task predicted lower anxious arousal neither habitual media violence usage anxious pleasant arousal predicted provoked aggression laboratory task scl unrelated aggressive cognitions behavior relations found habitual media violence viewing arousal response sad funny film clips arousal response sad funny clips predict aggressive cognitions aggressive behavior laboratory task suggests observed desensitization effects specific violent content
study examined patterns correlates types maltreatment experienced adolescents aged participating ongoing longitudinal study impact neglect children development using case record abstraction study compared child protection classification findings case record abstraction regard rates four types maltreatment physical sexual emotional abuse neglect well occurrence across multiple types maltreatment next study examined frequently observed patterns child maltreatment finally study investigated whether aspects caretaker functioning detailed incident characteristics cases neglect differed number different types maltreatment children experienced results showed significant discrepancies child protective service classification case record abstraction child protective service classification considerably underestimated rate occurrence across multiple types maltreatment neglect accompanied physical emotional abuse common form caretaker functioning variables distinguished number types maltreatment based findings future research directions practice implication discussed
study examined relationship exposure bollywood movies job seeking behavior south asian females using survey data collected female participants explored effects exposure bollywood movies job search self efficacy enjoyment job seeking behavior south asian females living united states canada united kingdom germany india pakistan also applied structural equation model examine role enjoyment job search self efficacy mediating relationship frequency exposure bollywood movies job seeking behavior results indicated exposure bollywood movies positively related enjoyment job seeking behavior female viewers bollywood movies also found significant relationship job search self efficacy job seeking behavior study offers significant insight role entertainment narratives influencing behavior south asian female audiences hitherto remained neglected group media effects research
study examined usefulness statistical parametric mapping spm investigating postmortem changes brain computed tomography retrospective study included patients years old without cerebral abnormalities underwent unenhanced brain death antemortem amct scans postmortem pmct scans spatially normalized using original brain template postmortem changes values hounsfield units analysed spm technique compared amct scans pmct scans showed loss cerebral sulci unclear grey matter white matter interface respectively spm analysis revealed significant decrease cortical density within min death pmct scans suggesting cytotoxic brain oedema furthermore significant increase density lenticular nucleus thalamus min death spm technique demonstrated typical postmortem changes brain scans revealed unclear interface early pmct scans caused rapid decrease cortical density combined delayed increase density spm may useful assessment whole brain postmortem changes aeuro cent original brain template achieved successful normalization brain morphology aeuro cent postmortem changes brain independent sex aeuro cent cortical density decreased rapidly death aeuro cent deep densities increased following cortical density change aeuro cent spm could useful assessment whole brain postmortem changes
study examined whether child abuse history teen mothers impacts offspring externalizing problems indirectly influence attachment maternal hostility longitudinal sample teen mother child dyads mothers reported abuse experiences attachment maternal hostility assessed via direct observations externalizing problems measured using maternal reports compared mothers abuse history mothers history sexual physical abuse likely insecurely attached infant predicted higher externalizing problems preschool turn predicted subsequent increases externalizing problems grade furthermore relative abuse history group mothers history sexual physical abuse showed hostility toward child preschool turn predicted elevated externalizing problems grade mothers history either sexual physical abuse alone significant indirect effects externalizing problems fostering secure attachment reducing risk maternal hostility might important intervention goals prevention programs involving risk mothers abuse histories elsevier ltd rights reserved
study examined whether features built environment residents perceptions neighborhood walkability safety social cohesion associated self reported physical activity community based activity among sample older adults mean age residing denver neighborhoods neighborhood walking audits conducted assess walkability social capital multilevel analyses walkability variables including curb cuts crosswalks density retail predicted greater frequency walking errands mean frequency walking errands sample low contrary expectations total community based activity highest neighborhoods fewer walkability variables higher respondent perceptions safety social cohesion seniors importance characteristics built environment promoting general activity engagement might secondary attributes social environment promote safety social cohesion
study examines aspects prediction suicide death undetermined intent investigated consecutive autopsied patients contact addiction centre malmo onwards staff asked shortly autopsy knew manner death thought patient committed suicide case records blindly evaluated toxicological autopsy findings alcohol blood samples investigated specificity prediction significantly often correct sensitivity suicide suicide death undetermined intent versus suicidal communication often considered non serious death undetermined intent suicide former could predicted ideation suicide attempt reported case records unlike suicide predicted undetermined group also showed higher levels alcohol blood autopsy concluded serious clinical investigation suicidal feelings may hidden taken seriously treatment alcohol use disorders active follow appear urgent efforts prevent suicide
study examines effects chronic repeated cumulative mediated exposure political violence ideological beliefs regarding political conflict centers effects young viewers preadolescents adolescents ideological beliefs refers support war perception threat one nation normative beliefs concerning aggression toward group longitudinal study conducted sample israeli palestinian youths experience israeli palestinian conflict firsthand two alternative hypotheses tested chronic exposure via media increases support war aggression elevates feeling threat chronic exposure via media strengthens preexisting beliefs results demonstrated higher levels exposure longitudinally related stronger support war regarding normative beliefs aggression threat one nation mediated exposure reinforced initial beliefs rendering youths extreme attitudes results mostly support conceptualization relation media violence behaviors reciprocally determined reinforcing spirals results also discussed light differences found effect exposure political violence firsthand exposure via media
study examines well known issue evaluating flutter probability long span bridge necessary assessing structural integrity reliability motivation stems need critically reviewing investigating number existing numerical approaches random perturbation analysis collocation methods galerkin approach modeling solution stochastic dynamic problems adapting specific problem study proposes generalized formulation stochastic bridge flutter terms random eigenvalue analysis suspension bridge model used numerical simulations compare various methods provide indications advantages limitations method moreover link proposed formulation existing studies propagation uncertainty aeroelastic systems example associated measurement errors wind tunnel examined elsevier ltd rights reserved
study examines two fundamental concerns context organizational change employees perceptions merger process justice cognitive trust top management team main purpose better understand nature reciprocal relations important constructs significant change event previous research building mainly social exchange theory framed trust consequence justice perceptions recently scholars suggested view may overly simplistic trust related cognitions may also represent important antecedent justice perceptions using wave longitudinal survey data gathered merger process tested reciprocal relations time cognitive trust top management team perceptions merger process justice contrast conventional unidirectional notion trust trust related cognitions outcomes perceived justice results show positive reciprocal relations time cognitive trust justice findings also revealed positive influence cognitive trust subsequent justice perceptions slightly robust opposite direction examining cross lagged longitudinal relations critical psychological reactions study contributes across multiple domains management literature including trust justice organizational mergers
study examines whether friendship facilitates hinders learning dyadic instructional setting working sex pairs girls boys middle school students years old taught new computer programming language programmed game students spent hours programming class beginning end project participant separately completed computer programming knowledge assessments questionnaires rating affinity partner results support proposition liking promotes learning greater partner affinity predicted greater subsequent increases computer programming knowledge partners one partner initial programming knowledge also positively predicted partner subsequent partner affinity elsevier inc rights reserved
study examines whether delivery three components exercise training behavior management skill building dementia related education evidence based program differentially associated changes outcomes individuals dementia iwds months data come iwds participating community replication evidence based reducing disability alzheimer disease program regression results indicate months exercise sessions associated improvements physical functioning mobility minutes exercising symptoms depression dementia education sessions related fewer restricted activity days behavior management sessions related symptoms depression resource strapped agencies look best serve participants analysis consideration needed determine ideal balance program efficacy feasibility resources well program benefits iwds caregivers
study explored stigmatized portrayals single womanhood news media content analyzing news coverage mainland china single women single men among three prevalent news frames conflict responsibility human interest results showed news reports relating single women commonly employed human interest frames concentrated single women conflicts social groups well conflicts singles societal expectation population sustainability news stories also unduly ascribed responsibility single women individual attribution applied single men exploratory study research shed light news framing gendered reinforce stereotypes facilitate mechanisms control theoretical practical implications discussed relation public opinion single womanhood intersectional oppression single women chinese society
study explores new security problem existing various state ofthe art quantum private comparison qpc protocols malicious third party announces fake comparison intermediate results case participants could eventually led wrong direction qpc become fraudulent order resolve problem new qpc protocol proposed second introduced monitor first one announces fake comparison intermediate result participants detect fraud immediately besides due introduction second proposed protocol allows strangers compare secrets privately whereas state art qpcs require involved clients know running protocol
study explores factors moderate first person perception socially desirable messages behavioral consequences perceived self perceptual disparity total participants watched inconvenient truth completed survey thereafter participants acknowledged receptive film others acted perceived difference supporting distribution film message desirability perceived message quality sensation value sensation seeking tendency issue knowledge affected assessments perceived effect self others differently also increased willingness take action stop global warming
study explores role gender constitution youth alcohol drug consumption australian drug education curriculum drawn analysis contemporary classroom drug education documents argued current drug education reproduces unethical harmful accounts femininity masculinity enactments gender primarily arise three ways first drug education currently positions young women consumption practices intrinsically problematic young men second drug education works position young women consumption practices problem spoiled reputation regret third drug education works responsibilise young women potential danger harm experience intoxicated without consideration illegal actions young men working annemarie mol notion ontological politics article argues australian drug education enacts gendered realities youth consumption work reproduce rather reduce range social harms drug related otherwise
study extends state space representation yield curve macroeconomy small open economy order study dynamic interaction yield curves canada framework treats term structure interest rates exogenous canadian yield curve macroeconomy empirical results support strong links yield curves two countries yield curve accounting much per cent variation movement level per cent movements slope curvature canadian yield curve canadian yield curve factors found account per cent variation output monetary policy rate per cent variation inflation much larger yield curve effects found future developments macroeconomies countries relatively strong bilateral relationship found exist yield curve instrument monetary policy supporting recent studies find dynamic relationship yield curve macroeconomy due pivotal role monetary policy plays macroeconomy elsevier inc rights reserved
study focused designing cost effective heat exchanger flinak sco secondary heat exchanger fluoride salt cooled high temperature reactors specific printed circuit heat exchanger geometries investigated cases fanning factor nusselt number correlations available straight shape offset strip fin zigzag channels considered sco side straight zigzag rectangle osf rectangle osf channels considered flinak side thermal hydraulics mechanical aspects corrosion rate taken account cost analysis performed combine effects heat transfer performance pressure drop heat exchangers single banking double banking also considered finally best pche channel configurations sco flinak sides proposed elsevier ltd rights reserved
study intended define implement activities ensure acquisition generic skills evaluate acquisition students perspective latter teacher research focuses official postgraduate studies develop field advanced manufacturing engineering open teaching obtain data combined analysis teachers internal vision student surveys external view results insight give idea activities designed although focused knowledge abilities technology skills combining methodology implicitly contemplated generic skills moreover external view corroborate especially considering student profile specialty studied also detect aspect improving
study investigated baseline client characteristics predicted long term treatment outcomes among adolescents referred school community sources enrolled usual care conduct substance use problems predictor effects multiple demographic age sex race ethnicity clinical baseline symptom severity comorbidity family discord developmental psychopathology behavioral dysregulation depression peer delinquency characteristics examined participants adolescents male mean age years diverse backgrounds hispanic american african american multiracial residing large inner city area expected characteristics three predictor categories related various aspects change externalizing problems delinquent acts substance use one year follow strongest predictive effect found baseline symptom severity youth greater severity showed greater clinical gains higher levels occurring developmental psychopathology characteristics likewise predicted better outcomes exploratory analyses showed change time developmental psychopathology characteristics peer delinquency depression related change delinquent acts substance use implications serving multiproblem adolescents tailoring treatment plans routine care discussed
study investigated developmental differences aversive conditioning extinction reinstatement recovery conditioned aversive associations following reexposure unconditioned stimulus post extinction study examined mechanisms children age years adolescents age years adults age years using differential aversive conditioning geometric shape conditional stimulus paired aversive sound another shape presented alone following extinction phase css presented alone half participants age group received three exposures reinstatement condition half control condition followed participants completing extinction retest phase day findings indicated significant differences generalizing aversive expectancies safe stimuli conditioning extinction persisted retest children relative adults adolescents significantly less positive reevaluations extinction persisted retest adolescents relative adults children reinstatement expectancies relative age groups results suggest important differences stimulus safety learning children stimulus valence reevaluation adolescents relative adults elsevier inc rights reserved
study investigated interactive exchange lovers associated interpersonal brain synchronization ibs using functional near infrared spectroscopy fnirs based hyperscanning three types female male dyads lovers friends strangers performed cooperation task brain activity recorded right frontoparietal regions measured better cooperative behavior lover dyads compared friend stranger dyads lover dyads demonstrated increased ibs right superior frontal cortex also covaried task performance granger causality analyses lover dyads revealed stronger directional synchronization females males males females suggesting different roles females males cooperation study refines theoretical explanation romantic interaction lovers hum brain mapp wiley periodicals inc
study investigated longitudinal relationships fathers involvement measured reading child socioemotional behavior infancy age intact two parent families millennium cohort study national cohort british children born variety covariates potential bidirectional nature relationships taken account path model showed fathers involvement children infancy significantly predicted better socioemotional behavior age although relationship strong fathers reading children ages significantly associated child socioemotional behavior mothers reading children age significantly associated improved child socioemotional behavior ages results also suggested parenting century british context remains fairly gendered mothers fathers likely engage physical activities sons artistic activities daughters fathers reading socially patterned predicted directions
study investigated influences retirement transition age gender aspects daily experiences adults aged years stayed working transitioned retirement data derived first second waves daily diary study national survey midlife united states participants completed telephone interviews experiences across eight consecutive days findings showed significant interaction effect retirement transition age daily stressors gender significantly moderate associations retirement transition daily experiences findings suggest retirement transition must considered context life course influences especially age better determine quality daily experiences midlife older adults life course influences considered programs services aimed help adults navigate retirement experiences
study investigated relationship childhood trauma irritability emotion recognition schizophrenia patients psychotic break thirty six schizophrenia inpatients healthy controls assessed irritability questionnaire irq two facial emotion recognition tasks emotion discrimination test edt emotion identification test eit patients assessed structured clinical interview dsm ili axis disorders scid positive negative symptom scale panss childhood trauma questionnaire ctq edt eit performance significantly impaired patients compared healthy controls furthermore patients tended misidentify sad surprised angry faces showing fear misidentification correlated patients irritability childhood adversity increased irritability directly indirectly emotion misidentification
study investigated whether increasing insoluble predominantly wheat bran fibre days improves subjective digestive feelings general wellbeing bowel function single centre multi site open within subjects design day non intervention baseline monitoring period followed day fibre consumption intervention period performed low fibre consumers day aoac completed daily symptom diary days consumed one bowl ready eat breakfast cereal containing least fibre wheat bran days completed daily symptom diary significant improvements demonstrated subjective perception bowel function ease defecation digestive feelings bloating constipation feeling sluggish digestive discomfort significant improvements also found subjective perception general wellbeing feeling less fat mentally alert slim happy energetic whilst experiencing less stress mental physical tiredness difficulty concentrating fewer headaches general improvements study outcomes increased increasing cereal fibre consumption however consuming additional minimum fibre wheat bran per day shown deliver measurable significant benefits digestive health comfort wellbeing encouraging consumption relatively small amounts wheat bran could also provide effective method increasing overall fibre consumption
study investigated whether personality traits psychopathological characteristics sociodemographic factors depressed patients differentiate patients suicidal thoughts attempted suicide investigated two groups patients affective disorder patients suicide attempt within last months sex ratio male female mean age male female years patients without suicide attempt suicidal thoughts sex ratio male female mean age male female years using comprehensive measurement mini international neuropsychiatric interview structured clinical interview dsm axis disorders hamilton depression scale beck depression inventory state trait anxiety inventory hamilton anxiety scale brief psychiatric rating scale clinical global impression scale beck hopelessness scale scale suicide ideation impulsivity rating scale barratt impulsivity scale inventory assessment aggression factors state trait anger expression inventory ways coping checklist several differences distinguished two groups namely personality traits anxiety coping strategies sociodemographics education level personality traits psychopathological characteristics sociodemographic factors useful tools assessing suicidal risk findings encourage suggest clinicians pay particular attention sociodemographic variables separation divorce lower education level conducting risk assessments suicidal patients
study investigates extent hyperactivity anxiety predicts susceptibility false confessions compared inattention anti social behavioural tendencies sample comprised young people males females education split three age groups years age ordinal logistic regression models show hyperactivity significant predictor reported false confessions across age whilst latent inattention significant predictor youngest group aged effect diminishes significantly older age groups latent anxiety seems exert significant effect across age antisocial behaviour asb however seems exert significant effect false confessions across age given recklessness impulsivity facets conduct disorder may recklessness impulsive component asb relevant predicting false confessions across age latent hyperactivity may therefore critical susceptibility factor false confessions across adolescence finding novel raises significant questions potential vulnerability adolescents scoring high hyperactivity questioned police crown copyright published elsevier ltd rights reserved
study investigates ideological implications real men korean reality show portrays experiences celebrities join military new conscripts situate popularity real men context changing gender geography korea analysis official real men online bulletin board explore male audience discourses regarding authentic military experience ideal soldiers related desire restore hegemonic masculinity findings suggest real men became vehicle used demand women appreciation difficult work men military desire symbolically remunerated military service involved positioning women primary caregivers fulfill traditional female roles calling restoration traditional gender roles male viewers attempted recover hegemonic masculinity perceived threat changing gender relations
study investigates neuroprotective properties berberine natural isoquinoline alkaloid isolated rhizoma coptidis finds berberine could promote beta amyloid beta clearance inhibit beta production triple transgenic mouse model alzheimer disease study berberine first administrated treat mice primary neurons morris water maze assay western blotting enzyme linked immunosorbent assay elisa immunofluorescence staining histological analysis transmission electron microscopic analysis used evaluate effects berberine administration result showed berberine significantly improved mice spatial learning capacity memory retention promoted autophagy activity identified enhancement brain beclin hvps cathepsin levels well reduction brain bcl levels mice facilitated reduction app levels reduced beta plaque deposition hippocampus mice inhibited site app cleavage enzyme bace expression similar results also found primary hippocampal neurons berbernine treatment decreased levels extracellular intracellular beta increased protein levels beclin hvps cathepsin decreased levels bcl app bace levels summary berberine shows neuroprotective effects mice may promising multitarget drug preventionand protection published elsevier inc
study investigates relationship outcome expectancy individual stress management course total perceived impact comprehensive stress management intervention smi based data different measurement points longitudinal smi switzerland individual organizational outcome expectancies stress management courses captured newly developed items smi outcome expectancy immediately course completion perceived individual organizational impacts overall intervention captured items retrospective impact assessment scale perceived smi impact year follow survey used outcome measurement baseline individual organizational change commitments rated participants included analyses possible moderators regression analyses show individual organizational outcome expectancies respect stress management courses extent predict perceived impact intervention whole individual level intervention perceived successful participants already high individual change commitment develop high outcome expectancies stress management courses
study investigates retention load zro primary crowns secondary polyetheretherketone peek crowns made different fabrication methods three different tapers standardized primary zro crowns fabricated three different tapers degrees degrees degrees group ten secondary crowns fabricated milled brecam biohpp blanks pressed industrially fabricated peek pellets biohpp pellet iii pressed granular peek biohpp granulat one calibrated operator adjusted crowns total secondary crowns measured pull tests min specimen tested times two one way anovas followed scheff post hoc test used data analysis within crowns degrees taper group showed significantly higher retention load values compared groups among degrees taper group presented significantly lower retention loads group however pressing type impact results within degrees taper fabrication method influence within group degrees taper showed significantly higher retention load compared ffi taper taper degrees range value degrees degrees tapers impact taper retention value observed groups within groups ffi taper presented significantly lower degrees taper whereas degrees taper showed differences fabrication method secondary peek crowns taper angles showed consistent effect within tested groups
study investigates use social networks scientific tool gathering medical data young subjects promoting healthier habits first hypothesis social networks facilitate epidemiological studies reducing time cost second question whether social networks enable collection data young healthy subjects otherwise beyond reach conventional social health polls facebook application created collect data concerning adherence mediterranean diet considering significant risk cardiovascular neurological degenerative diseases subjects poor adherence healthy diet users recruited short time without promotional action collected data indicate adherence mediterranean diet general greater older users young italian countries mainly participants statistical differences found concerning gender results show proposed approach offers advantages terms reduced cost faster data gathering processing improved efficiency compared form based epidemiology campaign however initial network may influence sample constitution age geographical location especially spread become viral autonomous based case study provide designers facebook apps simple guideline suggestions aimed maximizing heterogeneity sample order collect significant data proposed scenario suitable collecting health data easily extended fields
study concerned investigation rheological performance magnetorheological elastomers mres random distribution based modified magnetic particles also discusses electromagnetic shielding properties first time current work highlights necessity magnetic particles protection oxidation species affecting real application conditions two kinds mres differing matrix type represented silicone elastomer thermoplastic elastomer prepared pristine carbonyl iron particles siloxane modified particles used matrix difference magnetic properties modification particles negligible modification significantly improves anti acid corrosion properties moreover modification particles surface enhances compatibility silicone elastomer matrix evidenced measurements viscoelastic properties external magnetic field applied also shown developed mres successfully applied absorption electromagnetic radiation ultra high frequency band namely frequency range mhz ghz readily covered materials elsevier ltd rights reserved
study looks air separation facilitated transport hollow fiber membrane using cosalen pdms coated composite membrane facilitated transport membranes prepared using different cosalen contents coating solution effects physicochemical properties composite membrane thickness studied sem effect cobalt content coating layer studied edx effect thermal decomposition weight loss composite membranes studied tga functional group analysis pdms cosalen coated membranes studied atr analysis determine performance composite membranes facilitated transport membrane made cobalt complex presented value ideal gas selectivity addition good separation factor air separation showed low pressure bar operating pressure range elsevier rights reserved
study prospective cross sectional nature compared motor cognitive development hiv exposed unexposed infants first months age infants exposed hiv antiretroviral therapy experimental group unexposed infants control group participated study divided four age groups months old infants group infants evaluated motor cognitive development bayley scale infant toddler development performance category grading comparisons among scaled score composite score percentile rank held significant group effect scores motor cognitive domains showing lower scores regardless age comparison presented lower scores cognitive domain months performance categories infants classified average motor cognitive development except one month old infant classified borderline motor development infants exposed hiv antiretroviral therapy adequate cognitive motor development first months however lower scores found particularly month cognitive development may indicate future problems highlighting need systematic follow population elsevier ireland ltd rights reserved
study presented mechanism automatically identify consecutiveness textile patterns help classify ever growing number patterns pattern consecutiveness first decomposed two factors including repeat angle unit span pattern image sliced pieces various angles various spans similarity degree slices angle span calculated constitute similarity space peak values suggested potential repeat angles unit spans conjugacy repeat angles inspected similarity space conjugate angles advanced distinguish four consecutives two consecutives given relativity conjugate angles conjugate coefficient brought forward quantify conjugate level two perpendicular angles find optimal conjugate angles four consecutives peak significance proposed discriminate sharp peaks weak ones similarity spaces mono patterns investigated figure range peak significance mono pattern thus mono pattern could identified absence sharp peaks scheme consecutiveness identification based similarity space finally carried implemented computer programming proved highly accurate capable tolerating certain flawed pattern images
study presents methodology nonlinear quantification identification linear nonlinear regimes estimation degree nonlinearity cantilever beam local strongly nonlinear stiffness element interesting feature system behaves linearly limits extreme values nonlinear stiffness euler bernoulli cantilever beam two nonlinear configurations used develop demonstrate methodology one configuration considers cubic spring attached distance beam root achieve smooth nonlinear effect configuration considers vibro impact element generates non smooth effects systems property limit small large values configuration parameter system almost linear modeled negligible error beam cubic spring attachment forcing amplitude varied parameter vibro impact beam parameter clearance stiff stops beam static equilibrium proper orthogonal decomposition employed obtain optimal orthogonal basis used describe nonlinear system dynamics varying parameter values frequencies modes compose basis estimated using rayleigh quotient variations frequencies studied identify parameter values system behaves approximately linearly dynamical response highly nonlinear moreover criterion based betti maxwell reciprocity theorem used verify existence nonlinear behavior set parameter values suggested described methodology developed methodology general applicable discrete continuous systems smooth nonsmooth nonlinearities elsevier ltd rights reserved
study presents automatic human perception based chroma keying algorithm extracts objects interest foreground monochromatic background given image chroma keyed global colour distribution local texture property analysed ciecam colour appearance model analysis input image automatically segmented three parts foreground background uncertain regions afterwards background colour propagated known background uncertain region using interpolation functions foreground colour estimated based global colour distribution linear cost criteria quantitative perceptual comparisons matting results show proposed method reliably remove background region correctly restore intrinsic foreground colour accurately keep fine details addition authors implement proposed method heterogeneous parallel computing architecture efficiently distributes workload among different processors simulation results show foreground objects accurately extracted high definition ultra high definition videos real time
study presents control algorithms new unified power quality conditioner upqc without series transformers frequently used make insertion series converter upqc power supply load behaviour proposed upqc evaluated presence voltage imbalances well non sinusoidal voltage current conditions presented algorithms derive concepts involving active non active currents together phase locked loop circuit based real time algorithms considering proposed hardware topology upqc able compensate harmonic components voltages currents correct power factor keep load voltages regulated dynamic way responding instantaneously changes loads electrical power system control algorithms distributed two dsp digital control architecture without communication consequently increased sampling frequency acquired voltages currents improve upqc performance furthermore constraints proposed upqc evidenced particularly main voltages imbalanced simulation experimental results presented verify upqc performance transient steady state conditions
study presents development new fault zone identification scheme busbar using logistic regression binary classifier utilising one cycle post fault current signals bays connected busbar practicability presented scheme verified modelling existing indian power generating station power systems computer aided design electro magnetic transient design control software package presented scheme tested enormous cases generated varying system fault parameters proposed scheme provides effective discrimination internal external faults high overall accuracy moreover remains stable case heavy fault conditions particularly current transformer saturation conventional differential protection scheme mal operates furthermore provides equally compatible accuracy unknown system unseen data set well double one half breaker busbar arrangement addition performance proposed scheme verified laboratory prototype results found satisfactory average tripping time order case internal faults last comparative evaluation proposed scheme recently presented schemes literature indicates superiority
study presents findings depth interviews people families norway lost young son daughter traffic accident grief several dimensions loss young life loss life quality effect family events meaning new responsibilities brought onto family members young fatality many relatives friends affected wide range emotional socioeconomic consequences parents report grief overwhelming first years never disappears years slowly learn cope especially highlight role traffic authorities professional actors meet bereaved empathy minimize negative effects
study presents indoor soundscape framework detail describing variables factors form indoor soundscape study main objective introduce new indoor soundscaping framework systematically explain variables contribute overall evaluation indoor soundscape hence dependencies physical psychoacoustical factors sound environment spatial factors built entity statistically tested new indoor soundscaping framework leads overarching evaluation perspective enclosed sound environments combining objective room acoustics research noise control engineering architectural analysis therefore hypothesised case spaces certain plan organisations volumetric relations spatial referencing lead differentiated sound pressure level spl loudness values spl parametric variances sound environments discussed statistical findings respect architectural characteristics library case space results show relation crowd level variances sound environment parametric values statistically significant also found increasing atrium height atrium void volume atrium presence common architectural element interpenetrating reference domain containment results unwanted variances acoustic formations leading high spl values
study presents modelling dynamic simulation high penetration wind diesel power system wdps consisting diesel generator wind turbine generator wtg consumer load dump load battery energy storage system bess first wdps architecture models wdps components described wdps simulated wind mode running wtg supply active power wind diesel mode wtg supply power simulation results given showing graphs main electric variables wdps system frequency voltage active power component main battery variables current voltage state charge results mode show bess command proportional integral derivative pid controller supplies stores active power regulate isolated system frequency control enables bess smooth load wind power variations isolated system power quality improved also shown mode peak shaving application control orders bess supply active power temporarily support system frequency overload situation
study proposes novel methodology designing optimum equiripple finite impulse response fir filter processing cylinder pressure traces diesel internal combustion engine serve inputs high precision combustion analyses proposed automated workflow based innovative approach determining transition band frequencies optimum filter order methodology based discrete fourier transform analysis first step estimate location pass band stop band frequencies second step uses short time fourier transform analysis refine estimated aforementioned frequencies pass band stop band frequencies used determine appropriate fir filter order widely used existing methods estimating fir filter order effective suppressing oscillations rate ofheat release rohr trace thus hindering accuracy combustion analyses address problem innovative method determining order fir filter proposed study method based minimization integral normalized signal tonoise differences stop band frequency nyquist frequency developed filters validated using spectral analysis calculation rohr validation results showed filters designed using proposed innovative method superior compared using existing methods analyzed cases
study proposes performance driven control method performs control performance assessment control system design set closed loop data method assesses control performance based minimum variance control law closed loop data also calculates control parameter improves control performance closed loop data using fictitious reference iterative tuning frit method method characterized requiring system model effectiveness method verified numerical simulation application result temperature control unit
study provides first characterization early developmental trajectories corpus callosum segments rhesus macaques using noninvasive mri techniques assesses long term effects neonatal amygdala hippocampal lesions morphometry experiment monkeys males scanned week years age eight additional infants males scanned weeks age first months showed marked growth across segments sustained albeit slower growth months males females comparable patterns maturation overall exhibited slight differences anterior posterior segments greater increases isthmus males greater increases rostrum females developmental changes likely consequence varying degrees axonal myelination redirection pruning experiment animals neonatal lesions amygdala males hippocampus males scanned years post surgery compared scans six control animals experiment whereas amygdala damage yielded larger rostral posterior body segments hippocampal damage yielded larger rostrum isthmus differences demonstrate early perturbations one medial temporal lobe structure may produce extensive long lasting repercussions brain areas current findings emphasize complexity neural circuitry putatively subserving neurodevelopmental disorders autism spectrum disorder williams syndrome characterized malformations dysfunction complex neural networks include regions medial temporal lobe
study reports levels profiles phthalates dust samples collected three different microenvironments cars air conditioner filters household floor dust saudi arabia ksa kuwait best knowledge first study literature reporting phthalates indoor environments ksa makes findings important results showed bis ethylhexyl phthalate dehp butyl phthalate dbp isobutyl phthalate dibp octyl phthalate dnop major chemicals dust samples dehp overwhelming compound microenvironments occurred median concentrations saudi household floor car filter dust respectively median levels dehp kuwaiti car household floor dust samples times lower respective saudi dust phthalates higher car dust household dust filter dust suggesting people spending time vehicles higher risk exposure chemicals different exposure scenarios using percentile median mean percentile levels estimated adults toddlers saudi kuwaiti toddlers worst exposure scenario dehp cardiotoxic endocrine disruptor calculated body weight day respectively preliminary study provided first hand baseline data phthalates gulf countries necessitate detailed future studies region practical implications first study incidence phthalates different micro environments ksa high levels bis ethylhexyl phthalate dehp present kuwaiti ksa indoor micro environments suggesting high use dehp consumer products exposure phthalates via dust ingestion estimated high saudi toddlers cause concern elsevier rights reserved
study reports measurements solubility crystalline molybdenum trioxide moo acid hclo hcl aqueous solutions mostly pressures close saturated water vapor pressure solubility data explained two dissolution reactions moo hmoo log values equal moo hmoo log equal respectively combining results literature data thermodynamics hmoo ideal gas state evaluated henry constants form investigated temperatures turned close one would expect basis chemical similarity reasonable estimates fugacity coefficients hmoo steam allowed calculation vapor liquid distribution constant view lim species stand mole fractions solute coexisting vapor liquid phases respectively value krichevskii parameter governs variation investigated range temperatures equal mpa hmoo close mpa elsevier rights reserved
study started perspective predicting science technology competition building discuss dynamic competition android ios sales volume quarter lotka volterra system equations one well known competitive diffusion models adopted represent competitive situations smartphone operating system market lyapunov function used carry equilibrium stability analysis results showed android ios predator prey relationship ios serves predator android prey equilibrium stability analysis show products able coexist market thus system stable sales volume
study tested effects long term estradiol replacement social behavior gene expression brain nuclei involved regulation social behaviors adult female rats developed ultrasonic vocalization usv test sociability test examine communications social interactions social preference using young adult female cagemates rats ovariectomized ovx implanted silastic capsule containing vehicle housed treatment pairs month period rats behaviorally tested euthanized nuclei brain social decision making circuit selected neuromolecular profiling multiplex qpcr method novel usv test proved robust tool measure numbers types calls emitted cagemates reintroduced week separation results also showed treated ovx rats profoundly decreased numbers usv calls compared vehicle treated ovx rats test sociability female allowed choose cagemate treatment novel rat found effects compared vehicle although interestingly rats chose cagemate unfamiliar conspecific gene expression results revealed supraoptic nucleus greatest number gene changes caused oxt oxtr avp increased drd htrl grinb gabbrl decreased genes affected prefrontal cortex genes changed paraventricular nucleus pgr bed nucleus stria terminalis oxtr esr dnmta medial amygdala oxtr foxpl tac thus changes communicative interactions adult female rats together selected expression genes brain especially supraoptic nucleus elsevier inc rights reserved
study used three dimensional information stealth navigation technology simulated right internal jugular vein cannulation define initial needle trajectory taken using three approaches landmark short axis sax ultrasound long axis lax ultrasound nineteen volunteers indicated entry site needle direction track would use performing right internal jugular vein cannulation three approaches likelihood cannulation success arterial puncture needle direction recorded volunteers asked assess suitability simulation system validity educational benefit sax track crossed jugular vein frequently lax tracks sax lax sax versus mean indicated needle direction coronal plane sax lax degrees respectively track associated lax technique would entered carotid artery volunteers needle depths track crossed vertebral artery following rates sax lax use stealth technology provide three dimensional feedback needle path taken simulated right internal jugular cannulation considered realistic benefit respondents sax track associated highest likelihood successful jugular cannulation lowest cross rate carotid artery simulation model using stealth considered valuable realistic participants despite limitations
study uses formation mixed metal oxide inside ferritin tune band gap energy ferritin mineral mixed metal oxide composed formed reacting aqueous mno presence apoferritin altering ratio two reactants allowed controlled tuning band gap energies minerals formed indirect band gap materials indirect band gap energies ranging direct transitions also measured energy values ranging tuning band gap energies samples changes wavelengths absorbed mineral increasing ferritin potential solar energy harvesting additionally success using mno ferritin mineral formation opens possibility new mixed metal oxide cores inside ferritin
study uses workers compensation data describe work related injury experience massachusetts teens ages period injuries reported workers compensation system injuries frequent among year olds among males sprains strains followed lacerations frequent type injury four industries grocery stores restaurants health services department stores accounted half injuries overall injury rate full time equivalents ftes higher construction manufacturing wholesale trade sectors teens working apparel manufacturing nursing homes sustained highest rate injuries geographical analysis indicated teens living southeast region slate highest injury rates study adds existing evidence work related injuries teens substantial public health problem wiley liss inc
study accomplished using locations major ecological zones nigeria well different classes residential buildings different levels water consumption location house dwelling class level water consumption water balance approach used assess proportion water demand met rainwater results obtained indicate locations rainforest zone parts guinea savanna zone eighty percent water demand living bungalows met rainwater rainwater harvesting potential found power function rainfall coefficient variation coefficient alpha exponent beta high correlation coefficients parts per thousand currency signaeuro parts per thousand parts per thousand currency signaeuro parts per thousand obtained coefficient alpha roof area per capita also high correlation coefficients parts per thousand currency signaeuro parts per thousand parts per thousand currency signaeuro parts per thousand obtained exponent beta roof area per capita
study conducted order investigate function intervertebral disc degeneration serum concentration patients lumbar disc herniation ldh examined elisa immunohistochemistry western blot analysis performed detect expression disintegrin metalloproteinase thrombospondin motifs adamts tumor necrosis factor alpha tnf alpha degenerated intervertebral disc ivd tissues human rat moreover nucleus pulposus cells treated cytokine without tnf alpha adamts matrix metalloproteinases mmp mrna expression determined pcr expression signal transducers activators transcription stat stat stat detected western blot concentration level higher degenerated group positively correlates visual analog score vas adamts tnf alpha detected degenerative tissues human rat degenerated tissues mrna expression adamts tnf alpha mmp enhanced stimulation compared control stat stat stat expression also enhanced treatment stat significantly enhanced furthermore expression significantly reduced treatment mrna expression tnf alpha markedly reduced treatment compared treatment involved pathological development ivd degeneration could aggravate ivd degeneration stimulating tnf alpha stat signaling pathway
study conducted evaluate hypoglycemic hypocholesterolemic antioxidant properties mentha spicata labiateae leaves aqueous extract msla alloxan induced diabetic rats study hyperglycemia induced male rats intraperitoneal injection alloxan monohydrate aqueous extract spicata orally administered dose body weight diabetic rats days effects compared glibenclamid fasing blood sugar fbs body weight lipid profile serum malondialdehyde mda monitored days induction diabetes total phenol contents reducing power also evaluated aqueous extract galic acid respectively extract found administration spicata aqueous extract produced significant reduction fbs total cholesterol triglyceride low density lipoprotein cholesterol mda mumol respectively diabetic rats effects comparable effects standard antidiabetic drug glibenclamide results investigation indicated spicata leaf aqueous extract possess hypoglycemic hypocholesterolemic antioxidant properties diabetic rats therefore study suggest promising use treatment diabetes
study conducted provide fundamental data distribution radon concentrations child day care facilities south korea help establish radon mitigation strategies study child care centers randomly chosen child care centers nationwide alpha track detectors used examine cumulative radon exposure concentrations january may mean radon concentration measured korean child care centers approximately one third upper limit recommended south korea indoor air quality control public use facilities etc act environmental protection agency epa furthermore concentration lower measured concentration radon houses nationwide december february results indicate amount ventilation major determining factor indoor radon concentrations strongly correlated fluctuation indoor radon concentrations korean child care centers elsevier ltd rights reserved
study intended analyze intersection experience sexual stigma low socioeconomic status suicide attempt amongst young brazilians years old data collection periods participants completed questionnaire based instrument network analysis provided support minority stress model oriented around whether participants experienced sexual stigma although suicide attempts decreased participants experienced sexual stigma increase experienced sexual stigma particular note increases rates reported community familial physical assault molestation rape experienced sexual stigma analysis centrality statistics demonstrated experiences minority stress model fundamentally different disparities increased time frame observed study center model shortest paths statistics exhibited direct conditioned connection experiencing sexual stigma suicide attempts discuss social historical contexts contributed dynamics emphasize need policy change
study performed evaluate levels metals fish caught wadi hanifa main basin four seasons determine potential fitness fish human consumption evaluate overall water quality enforcement local standards physical chemical parameters total water samples tested using standard methods additionally total fish samples analyzed heavy metal concentrations mean values basic water quality parameters cod exceeded saudi standards seasons mean metal concentrations water consistently highest concentrations samples collected summer lowest samples collected winter mean metal concentrations fish muscle tissue exceeded saudi standards united nations fao standards statistical analysis showed highly significant positive correlations metal concentrations water metal concentrations fish muscle study highlights urgent need monitoring controlling wastewater discharge wadi hanifa ensure public safety
systematic review aimed provide comprehensive summary current literature neurobiological underpinnings experience negative moral emotions shame embarrassment guilt psycinfo pubmed medline used identify existing studies twenty one functional structural magnetic resonance imaging positron emission tomography studies reviewed although studies differed considerably methodology findings highlight shared distinct patterns brain structure function associated emotions shame likely associated activity dorsolateral prefrontal cortex posterior cingulate cortex sensorimotor cortex embarrassment likely associated activity ventrolateral prefrontal cortex amygdala guilt likely associated activity ventral anterior cingulate cortex posterior temporal regions precuneus although results point common distinct neural underpinnings emotions research required replicate findings elsevier ltd rights reserved
two wave survey study investigated concurrent longitudinal relationships different styles restrictive active parental mediation autonomy supportive controlling inconsistent adolescents media violence exposure aggression sample consisted adolescents years girls results indicate restrictive mediation communicated autonomy supportive style concurrently related decreased aggression via decreased media violence exposure contrast inconsistent restrictive mediation concurrently related increased aggression via increased media violence exposure significant relationships found controlling restrictive mediation none restrictive mediation styles longitudinally related media violence exposure aggression active mediation moderated neither concurrent longitudinal relationships media violence exposure aggression regardless style used findings suggest autonomy supportive restriction may effective route parents concerned child media violence exposure aggressive behavior elsevier ltd rights reserved
work addresses creation development framework application developers create natural way immersive physical activities users experience first person perception full body control proposed framework based commercial motion sensors head mounted display hmd uses unity unifying environment user pose virtual scene immersive visualization functions coordinated proposal exemplified development toy application showing practical use
work aims giving guidelines assess impact performance indicators organisations performance measurement systems usually introduced organisations order monitor goal achievement allocate resources implement strategy however implementation performance indicators may generate alteration rational behaviour monitored structure risk impact always present must considered carefully order preserve organisation counter productive effect present analytical work reference model proposed first step model considers organisational dimensions indicator may exert influence method makes use four kaplan norton balanced scorecard perspectives order identify dimensions indicator may exert impact previous works reported scientific literature provide operational models impact analysis whereas proposed model linked operative procedure order support management make analysis aim make impact analysis less complex structuring sequence predefined steps proposal supported practical examples
work considers parallel algorithm solving multidimensional multiextremal optimization problems algorithm uses peano type space filling curves dimension reduction conditions non redundant parallelization algorithm considered efficiency algorithm modern computing systems use graphics processing units gpus investigated speedup algorithm using gpu compared algorithm implemented cpu demonstrated experimentally computational experiments carried series several hundred multidimensional multiextremal problems
work describes micro patterning surface texturing technique fixed work surface using proposed new spindle system rotating cutting tool controlled real time proposed spindle system creates micro sized patterns using rotating tools micro milling tool micro grinding wheel shaft spindle suspended air bearings electromagnetic actuator controls radial motion spindle housing instead shaft generates micro pattern array electro less coated workpiece micro milling process pid controller adopted make system stable adaptive feedforward cancellation used effectively compensate run spindle system machining machining results show compensation improves pattern accuracy expected micro patterning using proposed spindle system applied large surface area elsevier ltd rights reserved
work describes electrical interferometer contactless permittivity measurements working ghz fabricated sige process featuring fmax ghz chip system contains ghz vco tuning range ghz featuring divide circuit enable external pll operation subsequent buffer provides dbm output power ghz additionally contains high precision high resolution phase shifters based slow wave transmission line approach digital control direct readout ability ghz lna gain power detector provide output signals realized chip enables sample emulation capability phase shift inducement measurement well reference transmission line terms phase detection system shows sensitivity mhz degrees
work describes integrated method modelling algorithms modal approach multibody environment provides slimmer efficient simulation flexible component contacts realistically reproducing system impacts vibrations non linear numerical model impulse contact forces based continuity approach lankarani nikravesh developed model developed evaluate deformation energy taking account material characteristics surface geometries velocity variations bodies contact adams type modelling applied sliding contacts links chain mechanical tensioner blade timing internal combustion engine blade discretized subdividing smaller components inter connected corresponding centres gravity general forces static dynamic tests performed evaluate stiffness damping friction parameters multibody model validate methodology
work describes dynamic characteristics novel soft magnetic entangled metallic wire material emwm dynamic tests first time mechanical properties three batches emwms different porosities investigated different dynamic loads different magnetic field intensities result shows properties storage modulus loss factor commendably controllable magnetic responses magnetic field particular dynamic damping remarkable quasi static performance loss factor improved magnetic field results indicate emwm magneto sensitive smart material possesses considerable application prospect active vibration control variable stiffness damping
work describes enzymatic degradation combined hollow capsules via layer layer lbl self assembly technique previously showed build characterization capsules composed synthetic poly sodium styrene sulfonate poly allylamine hydrochloride biodegradable heparin chitosan polyelectrolytes biocatalytic response assembled multilayer capsules provides functional oriented approach controlled release encapsulated molecules case multilayer capsule disassembled heparinase morphological change individual capsule assessed atomic force microscopy confocal laser scanning microscopy sustained release encapsulated fitc dextran model realized enzymatic degradation capsule shells heparinase release profile fitc dextran indicated successful control concentration dependent manner shows applicability smart drug delivery system wiley periodicals inc appl polym sci
work describes practical implementation interleaved multi phase multiswitch boost converter fuel cell applications paper aims validate concept digitally controlled multi interleaving boost converter pisq fuel cell applications two phase four legs per phase synchronous boost converter abbreviated mibc compared interleaved boost converter ibc mibc exhibits interesting performance terms magnetics input output current ripple part count distributed power losses potential field application indeed medium higher power fuel cell front end converters minimizing input current ripple significant also redundancy reliability crucial actually approach covers aspects since provide module device redundancy real time flexible digital control reconfiguration relevant aspects related design modeling simulation experimental verification fpga controlled mibc treated paper copyright hydrogen energy publications llc published elsevier ltd rights reserved
work explores mindful leadership practice inform school district leadership specifically occurs professional learning communities plc school district leaders create plc cultures encourage rich thinking intentional practice individual organizational mindfulness present leaders work craft informed responses demands argued mindfulness places position maximize learning experiences moment organizational structure plc provides school members location practice mindful leadership yet plc become end structure organizes participants lacks necessary goal orientation actors engage motivating purposeful work create meaningful outcomes assert mindful institutionalization plcs orients school toward cultural change embodied collective attention orients work members argue requires attention deeply developed explanations activities within school setting opportunities formative substantive data use ground real time orientation communal learning argue attention themes would enhance knowledge skill set available plc members
work falls category linear cellular neural network cnn implementations detail first investigative attempt cmos analog vlsi implementation recently proposed network formalism introduces time derivative diffusion cnn cells nonseparable spatiotemporal filtering applications temporal derivative cnns tdcnns reported circuit consists array filters arranged regular pattern across space show state space coupling based array elements realizes stable linear first order temporal tdcnn dynamics implementation based linearized operational transconductance amplifiers class current mirrors measured results investigative prototype chip confirms stability linearity realized tdcnn provided prototype chip built ams cmos technology occupies total area consuming per processing cell copyright john wiley sons ltd
work investigates role intake generated thermal stratification temperature field evolution compression stroke using direct numerical simulation analysis compares two direct numerical simulations compression stroke one initialized homogeneous temperature distribution one stratified temperature field resulting precursor direct numerical simulation intake stroke initial boundary conditions identically imposed results show thermal situation bottom dead center nearly impact evolution temperature field wall heat transfer compression dominating mechanism temperature field evolution found convective transport cold gases boundary layers toward cylinder center consequence wall temperature flow field main influencing parameters controlling evolution temperature distribution compression finding assist practical engine experiments since points mechanisms promising affect temperature field compression stroke addition explains stratification temperature field intake varying gas temperatures two intake channels showed minor impact thermal situation top dead center
work aimed improve teaching effect practice link water pollution control engineering course added three new sections traditional wastewater treatment experiments named observation laboratory wastewater treatment process observation tertiary treatment device filtration backwash experiments via practice reform proved successful increasing students ability solving practical problems well engineering consciousness
work lies within scaltech project whose main purpose investigate performance technology terms signal processing quality power consumption radiation hardness applications instrumentation electronics particle physics respect previous technological generations additional target experimentally evaluate radiation damage effects single devices full circuits develop rad models simulations test chip including elementary device arrays dedicated read circuits developed fully characterized particular capacitance frequency converter integrated measure matching different capacitors programmable array experimental results show matching performance comparable previous technologies making technology eligible analog signal processing front end circuits physical experiments related data converters samples sent irradiation facility high energy experiments compliance verification
work presents low intrusive system identification parameters motor model estimate electrical machine efficiency operation metallic base supports electrical generator coupled motor generator output connected replaceable electrical resistances order control mechanical load shaft also control system implemented dedicated microprocessor order apply different excitation signals motor current angular velocity signals acquired adc system communicates computer usb channel dynamic equations describe motor discretized rearranged order apply iterative least squares algorithm running computer finally electrical mechanical parameters model winding inductance resistance mechanical moment inertia friction coefficient general torque constant estimated thus system estimates motor losses parameters approximates motor efficiency results validated indirect measurement mechanical power load cell measures reaction force produced generator tachogenerator measures angular velocity estimated output power well estimated efficiency follow measured mechanical power shaft results shown system used alternative non intrusive method
work presents low complexity audio coder decoder codec based fixed point arithmetic save usage system resources low end embedded system reduce time complexity memory usage simplified discrete wavelet transform dwt integer operations developed simplified dwt reduces computation required trigonometric operations fixed point system moreover separating even odd orders wavelet coefficients halves computation time original dwt additionally tri mode zeroes recording algorithm tzra proposed proposed tzra utilizes different encoding modes corresponding bit data structures record locations zero wavelet coefficients determines optimal encoding mode uses fewest bits improve compression performance dynamic wavelet level selecting algorithm developed decide wavelet level compressing frame algorithm dynamically select optimal wavelet level fewest bits using determined mode tzra experimental results herein reveal encoder proposed codec multiply computation factors reduce size execution file approximately relative baseline audio compression codecs results indicate efficiency used real consumer products fixed point arithmetic
work presents method determine mechanical transfer functions forces acting stator teeth electrical machine surface velocities sound radiating surfaces method allows efficient analysis drive trains target application real environment determined transfer functions used transient acoustic model simulation electrical drive trains proposed model takes care nonlinear power electronics digital control sensors well tolerance afflicted geometries electrical machines real tolerance deviating material properties model validated means vibration measurements benefits closed simulation time domain declared exemplary applications proposed model discussed potential acoustic evaluation design process electrical machine illustrated
work presents new methodology automate derivation building energy models bems complex computer aided design cad geometry goal combine current parametric modeling digital fabrication computer graphics techniques automatically generate geometric input energy model digital model building automation facilitates use implementation goal oriented design methods integrate energy performance types building performance models work mesh planarization algorithms currently used computer graphics digital fabrication methods used adapted automate optimize parsing non planar surfaces energyplus popular bem engine proposed methodology facilitates modeling thermal zones double curved envelopes time consuming task typically requires high level expertise energy modeler proposed single streamlined workflow generates digital models suitable energy optimization digital fabrication thereby facilitating integration two parallel design procedures core architectural design process workflow single cad model generates solutions energy efficient feasibly fabricated using digital techniques goal oriented design workflow applied study fritting pattern densities three complex double curved building geometries elsevier ltd rights reserved
work presents topology pulsed current power supply suitable particle accelerator applications current pulse generated energy provided structure tied electrical network one connected capacitor bank used local energy storage using structures disturbances electrical network minimized since power obtained grid limited average active power load management reactive power lies energy storage structure control scheme power management structures presented simulations carried taking account parameters particle accelerator transfer line
work presents application comprehensive predictive modeling methodology single multiphysics time dependent systems developed cacuci ionescu bujor paradigm spent fuel dissolver model interest nonproliferation objectives order quantify uncertainties due dissolver model parameters subsequently combine available experimental computational information obtain best estimate values model responses parameters along reduced predicted uncertainties predictive modeling methodology uses maximum entropy principle construct optimal approximation unknown priori distribution priori known mean values uncertainties characterizing model parameters computed experimentally measured model responses approximate priori distribution subsequently combined using bayes theorem likelihood provided multiphysics computational models finally posterior distribution evaluated using saddle point method obtain analytical expressions optimally predicted values parameters responses multiphysics models along corresponding reduced uncertainties weighting functions used within predictive modeling methodology provided first order sensitivities functional derivatives model response respect model parameters dissolver model comprises model parameters related model equation state inflow conditions sensitivities model parameters acid concentrations instances time computed exactly efficiently accompanying work peltz cacuci using adjoint sensitivity analysis method sensitivities used work quantify uncertainties acid concentration system responses various dissolver compartments arising uncertainties model parameters subsequently sensitivities used within predictive modeling methodology combine computational results available experiments performed solely compartment farthest inlet results applying predictive modeling methodology yield optimally calibrated values model parameters reduced predicted uncertainties well optimal best estimate predicted values acid concentrations also reduced predicted uncertainties notably even though experimental data pertain solely compartment farthest inlet data measured predictive modeling methodology actually improves predictions reduces predicted uncertainties compartment data actually measured also throughout entire dissolver including compartment farthest measurements inlet predictive modeling methodology combines transmits information simultaneously entire phase space comprising time steps spatial locations results obtained work establish confidence dissolver model accuracy simulating acid concentrations required dissolve used nuclear fuel turn results used generate source terms key reprocessing facility components downstream support material accountability nuclear safeguards
work presents development system dynamic model use recycled material construction demolition waste production non structural concrete blocks using software stella modeling parameters modeling allows individual analysis production process parameters serving base definition critical activities possibilities improvement optimization production modeling also validation criterion ensure efficient reuse construction waste given current regulations environmental technical specifications study resulted conceptual analysis model considering several variables related production process possible demonstrate use construction demolition waste feasible social environmental activity economic potential
work presents uncertainty quantification includes parametric inference along uncertainty propagation adsorption hollow fiber sorbent complex dynamic chemical process parametric inference via bayesian approach performed using sequential monte carlo completely parallel algorithm predictions obtained propagating posterior distribution model presence residual variability observed data model inadequacy often present significant challenge performing parametric inference work residual variability observed data handled three different approaches performing inference isolated data sets increasing uncertainty model parameters finally using model discrepancy term account uncertainty pros cons three approaches illustrated along predicted distributions breakthrough capacity scaled process american institute chemical engineers
work proposes three wave method perturbation parameter obtain exact multi soliton solutions nonlinear evolution equation dimensional kdv equation used example illustrate effectiveness suggested method using method new multi soliton solutions given specially spatiotemporal dynamics breather two soliton multi soliton including deformation bright dark multi soliton deflection different directions angles investigated exhibited kdv equation new nonlinear phenomena revealed small perturbation parameter
work provides comprehensive literature review evaluate expected impacts introduction electric vehicles power electric system smart grid examining case brazil previous studies point different impact levels introduction electric vehicles country electric grid varying small impacts substitution fleet potential difficulties fleet replaced electric vehicles offer significant advantages internal combustion engine powered vehicles counterparts including higher efficiency performance electric motor reduced pollution emissions operation decreased noise levels current disadvantages lie mainly higher vehicle battery costs relatively long battery charging period required limited battery lifetime need increase market availability brazil electricity generation capacity primarily based clean renewable energy hydropower wind biomass providing preferred approach charge electric vehicles minimal carbon pollutant emissions introduction smart grids country electricity distribution structure electric vehicles also provide pathway renewable energy options toward cleaner electricity leveling power demand cycle lowering need add costly central station generation integrating grid periods used transportation however careful studies must conducted mainly due need increase electric power generation meet existing imminent demands
work systematically studied heat transfer characteristics porous green building materials base materials porous green building materials closed cell aluminum foams led lamp inserted porous material porous materials may enhance heat transfer capacity heat sink led lamp due high thermal conductivity total four kinds test heat sinks employed model copper alloy powder composite graphite heat sink annular aluminum alloy conductive base model aluminum alloy powder composite graphite heat sink annular aluminum alloy conductive base model composite graphite heat sink annular aluminum alloy conductive base copper foam fins model aluminum alloy heat sink philips led lamp model master led par results showed height present ceiling upper space sensitive parameter heat transfer therefore lower ceiling upper space suitable installing among various heat sinks model heat sink lowest total thermal resistance thermal resistance model heat sink inserting closed cell aluminum foam ceiling times inserting wooden ceiling three heat sinks similar thermal resistances thermal resistances three heat sinks inserting closed cell aluminum foam ceiling times inserting wooden ceiling work demonstrates closed cell aluminum foam ceiling help cooling led lamp elsevier ltd rights reserved
work uses benchmark verify accuracy efficiency mocum code parallel neutronics program based method characteristics moc arbitrary core geometries compared references mocum eff assembly pin power maximum percentage errors respectively parallel algorithm achieves speed ups times compared calculation speed using one thread sensitivity study various moc parameters reveals benchmark problem requires azimuthal angles strong flux gradient heterogeneous effects demand fine unstructured meshes yield accurate flux solution simulation uses million zones average mesh size investigation polar angle quadrature indicates leonard polar angle performs slightly better three polar angles necessary addition parameter sensitivity study shows coarse parameters prone introduce error neutron flux eff elsevier ltd rights reserved
though bubble column reactors widely used industry present design practice still closer art desired state science complexity fluid mechanics empiricism reduced understanding detailed flow pattern turbulence characteristics turbulent structures effects performance mixing axial mixing phases rate heat mass transfer purpose present work cfd simulations undertaken using standard epsilon rsm les turbulence models cylindrical column computational height inside diameter employed bubble column operated three superficial gas velocities instantaneous three dimensional velocity field obtained means two phase eulerian eulerian large eddy simulations les conservation equations turbulent kinetic energy turbulent energy dissipation rate epsilon derived two fluid governing equations using reynolds averaging procedure enabled accurate estimation convective transport diffusive transport turbulent transport production dissipation epsilon estimations compared modelled terms standard epsilon reynolds stress models difference values gives idea severity assumptions made models attempt made bring implications simplifying assumptions elsevier ltd rights reserved
three dimensional printing involves number additive manufacturing techniques used build structures ground technology adapted wide range surgical applications impressive rate used print patient specific anatomic models implants prosthetics external fixators splints surgical instrumentation surgical cutting guides profound utility technology surgery explains exponential growth important learn printing used surgery potentially apply technology pubmed searched studies addressed clinical application printing surgical fields yielding results data manually extracted included studies found exponential increase studies addressing surgical applications printing since largest growth craniofacial oromaxillofacial cardiothoracic specialties pertinent considerations getting started printing identified discussed including software printing techniques printing materials sterilization printing materials cost time requirements also diverse increasing applications printing recorded discussed large array potential applications printing decreasing cost increasing ease use making technology available incorporating printing surgical practice rewarding process yields impressive results
three educational institutions south dakota collaborating develop pre engineering courses increase enrollment success students transferring oglala lakota college olc year bachelor degree programs science engineering south dakota school mines technology sdsmt south dakota state university grant national science foundation tribal colleges universities program tcup activities grant led partnership native led thunder valley community development corporation tvcdc provided significant opportunities students olc sdsmt areas civil engineering sustainability recent opportunity includes incorporating tvcdc plans person net zero regenerative community pine ridge indian reservation capstone design course sdsmt project includes sustainable design objectives wastewater treatment rainwater harvesting use straw bale compressed earth walls renewable building materials phase planned community four teams students working regenerative community four teams students working traditional capstone design project completed proposals first progress reports fall semester comprehensive assessment team member effectiveness catme instrument administered twice semester evaluate team functioning comparison data two capstone projects presented results surveys indicate students working regenerative community project positive consistent behavioral satisfaction categories within peer evaluation survey
three identical solar tunnel greenhouse dryers forced convection mode installed drying peppermint plants thermal analysis solar tunnel greenhouse peppermint dryer investigated based thermal balance equations order predict performance performance solar greenhouse dryer studied function change plant conditions air flow rates peppermint loads two fan operating systems evaluated terms system temperatures drying rate drying efficiency product quality drying cost obtained data revealed drying peppermint leaves reduce drying time achieve highest percent volatile oil compared drying whole plants drying peppermint flow rate min load greenhouse operate greenhouse continuously fan operating system tends increase drying rate whole plants leaves comparing periodical system elsevier ltd rights reserved
three novel differential amplifier topologies using double gate igzo tfts flexible substrate presented paper designs exploit positive feedback load self biased top gate achieve highest static gain single stage igzo amplifiers reported date fabrication three amplifiers exhibit respectively static gain bandwidth khz also circuit input referred noise measured rms rms rms respectively based results igzo amplifier providing highest gain suitable front end heart rate measurements optimization verified simulation also used bio potential applications like electro hysterogram electro cardiogram
three studies examined hypothesis bilinguals rapidly disengage attention irrelevant information monolinguals investigating impact previous trial congruency performance simple flanker task study monolingual bilingual young adults completed two versions flanker task differences language groups mean reaction time using standard analyses congruent incongruent trials size flanker effect sequential congruency effects sces however account previous trial congruency smaller bilinguals monolinguals finding strongest shortest response stimulus interval rsi study replicated effect using slightly different flanker task shorter rsi study study showed long rsis behavioral sce differences groups disappear sufficient time recover previous trial event related potentials demonstrated continued influence previous trial congruency monolinguals bilinguals replicating reaction time effects studies together studies demonstrate bilinguals experience less influence previous trial congruency greater ability disengage attention previous trial order focus attention current trial found monolinguals elsevier rights reserved
three studies examined impact sexual aggressive song lyrics aggressive thoughts emotions behavior toward opposite sex study authors directly manipulated whether male female participants listened misogynous neutral song lyrics measured actual aggressive behavior male participants exposed misogynous song lyrics administered hot chili sauce female male confederate study shed light underlying psychological processes male participants heard misogynous song lyrics recalled negative attributes women reported feelings vengeance heard neutral song lyrics addition men hating song lyrics similar effect aggression related responses female participants toward men finally study replicated findings previous two studies alternative measure aggressive behavior well subtle measure aggressive cognitions results discussed framework general aggression model
three dimensional core shell organic inorganic hybrid solar cells tunable properties demonstrated via electropolymerization air stable poly ethylenedioxythiophene pedot shells controlled thicknesses rapidly coated onto periodic gaas nanopillar arrays conformally preserving vertical structure properties organic layer readily tuned situ allowing lowering highest occupied molecular orbital level vertical bar delta vertical bar similar leading increase open circuit voltage improvement pedot conductivity results enhanced short circuit current densities incorporation various anionic dopants polymer coating process also enables tailoring polymer semiconductor interface transport properties systematic tuning device properties results peak external quantum efficiency leading power conversion efficiencies
three dimensional mofs htz tetrazole synthesized methanol characterized chemical analysis element analysis spectroscopy single crystal ray diffraction thermal analysis thermogravimetric analysis demonstrated mofs removing methanol molecules possessed good thermostability decomposition temperature enthalpy change liquid phase formation reaction determined microcalorimeter value mol enthalpy change solid phase formation reaction calculated mol basis designed thermochemical cycle thermodynamics formation reaction mofs investigated changing temperature liquid phase reaction based experimental results fundamental kinetic thermodynamic parameters obtained specific heat capacity determined calorimeter addition constant volume combustion energy title mofs determined rbc rotating bomb calorimeter standard molar enthalpy combustion standard molar enthalpy formation calculated mol mol respectively
three dimensional point cloud registration important reverse engineering paper propose registration method large scale point clouds based neighborhood constraints geometrical features method consists initial exact registration steps process initial registration define new functon measures feature similarity calculating distance function process exact registration introduce angle information improve accuracy iterative closest point algorithm compared traditional feature based iterative closest point algorithms method significantly reduced registration time registration error traditional feature based algorithm proposed algorithm used create efficient models virtual plant reconstruction computer aided design registration results provide reference virtual plant reconstruction growth
three dimensional symmetric tensor fields wide range applications solid fluid mechanics recent advances topological analysis symmetric tensor fields focus degenerate tensors form curves paper introduce number feature surfaces neutral surfaces traceless surfaces tensor field analysis based notion eigenvalue manifold neutral surfaces boundary linear tensors planar tensors traceless surfaces boundary tensors positive traces negative traces degenerate curves neutral surfaces traceless surfaces together form partition eigenvalue manifold provides complete tensor field analysis degenerate curves alone also extract visualize isosurfaces tensor modes tensor isotropy tensor magnitude found useful domain applications fluid solid mechanics extracting neutral traceless surfaces using marching tetrahedra method cause loss geometric topological details lead false physical interpretation robustly extract neutral surfaces traceless surfaces develop polynomial description enables borrow techniques algebraic surface extraction topic well researched computer aided design cad community well algebraic geometry community addition adapt surface extraction technique called patches improve speed finding degenerate curves finally apply analysis data solid fluid mechanics well scalar field analysis
series long term column experiments fate three common pharmaceuticals carbamazepine cbz diclofenac indomethacin major phase metabolites soil aquifer treatment sat monitored cbz concentration increased factor two regardless treatment conditions metabolites dihydro hydroxycarbamazepine approximately sat cbz epoxide sat effectively removed sat results indicated metabolites pharmaceuticals present much higher concentration original forms sat effluent metabolites persistent sat relatively short retention time days study indicated attention paid formation fate metabolites water quality management sat effluent
study agricultural service cooperatives russia belgorod region article addresses two gaps literature first dearth empirical studies cooperatives post socialist russia second lack attention top cooperatives global literature overly negative approach topic extant studies whereas state attempts establish agricultural cooperatives russia top fashion largely failed cooperatives sprung widely belgorod article investigates influence regional state exerts cooperatives affects daily functioning viability extent top cooperatives might evolve less state led forms classic member driven business like cooperatives
symbolic computation maple class lump solutions rationally localized directions space dimensional kadomtsev petviashvili equation presented making use hirota bilinear form resulting lump solutions contain six free parameters two due translation invariance equation four satisfy non zero determinant condition guaranteeing analyticity rational localization solutions three contour plots different determinant values sequentially made show corresponding lump solution tends zero determinant approaches zero two particular lump solutions specific values involved parameters plotted illustrative examples elsevier rights reserved
prevention unintended pregnancy contraception improve women health social economic well families hand contraceptives lead reducing birth rate becomes pronounced romania also lot side effects especially used without prescription aim study identify role internal external factors use misuse oral contraceptives results shown correlation factors appearance side effects aggravation existing ones decisive role giving contraceptives based obtained results needed initiate adequate measures minimize side effects prevent people renouncing use contraceptives
throughout history natural ventilation remained preferred choice majority residential buildings commercial buildings natural ventilation went single option somewhat lost art mechanical ventilation systems air conditioning became standard second half twentieth century recently result environmental concerns particular greenhouse gas emissions buildings interest natural ventilation commercial buildings seen resurgence unfortunately hiatus natural ventilation use buildings resulted loss existing design know consequently limited new developments period comfort indoor air quality performance standards continuously risen nevertheless past years seen significant advances understanding fluid mechanics natural ventilation architectural fluid mechanics developed new subject response new scientific advances attempt restore confidence applicability natural ventilation practice paper presents ten questions building natural ventilation span different scales problem urban context neighbourhood building questions commonly asked designer considering natural ventilation preferred means cooling non domestic building answers intended provide succinct links latest knowledge identify areas require additional research assist designers making appropriate decisions elsevier ltd rights reserved
thyroid function closely interlinked pregnancy maternal foetal outcomes improved optimal thyroid function achieved maintained prior conception needs systematic approach includes rational screening appropriate management pragmatic counseling review describes pre conception management thyroid disorders completes earlier article preconception management endocrine diseases
thyroid hormones ths crucial brain development maturation vertebrates especially pre perinatal development disruption signaling leads multitude neurological deficits many animal models provided insight role ths brain development specific data affect brain ability learn adapt depending environmental stimuli rather limited review focus number learning processes like spatial learning fear conditioning vocal learning imprinting behavior abnormal signaling development shapes subsequent performance clear multiple studies deprivation leads defects learning fronts interestingly changes local expression activator deiodinase type seem important role taking account ths regulated space specific manner thus increasing pressure investigate local regulators potential factors involved neuroplasticity learning processes also important proper adult human functioning elucidating role ths developmental neuroplasticity various animal models important field advancing fundamental applied knowledge human brain function elsevier inc rights reserved
thyroid hormones influence renal development kidney hemodynamics glomerular filtration rate sodium water homeostasis hypothyroidism hyperthyroidism affect renal function direct renal effects well systemic hemodynamic metabolic cardiovascular effects hypothyroidism associated increased serum creatinine decreased glomerular filtration rate reverse effects reported thyrotoxicosis renal manifestations thyroid dysfunction reversible treatment kidney disease may also cause thyroid dysfunction several mechanisms nephrotic syndrome associated changes serum thyroid hormone concentrations different forms glomerulonephritis tubulointerstitial disease may linked thyroid derangements high prevalence thyroid hormone alteration reported acute kidney injury thyroid dysfunction highly prevalent chronic kidney disease patients subclinical hypothyroidism low triiodothyronine syndrome common features patients chronic kidney disease patients treated hemodialysis peritoneal dialysis renal transplantation recipients exhibit thyroid hormone alterations thyroid disease higher frequency found general population drugs used therapy thyroid disease may lead renal complications similarly drugs used kidney disorders may associated thyroid alterations lastly low thyroid hormones especially low triiodothyronine levels patients chronic kidney disease related higher risk cardiovascular disease cause mortality interpretation interactions thyroid renal function challenge clinicians involved treatment patients thyroid kidney disease
tick borne infectious diseases allergies growing problem worldwide tick bite allergy associated direct effect immunoglobulin ige response tick salivary antigens secondary induction allergy red meat consumption ige antibodies carbohydrate alpha gal gal alpha gal beta glcnac however despite growing burden pathology proteins associated anaphylaxis tick bite characterized address question comparative proteomics approach used characterize tick proteins producing ige antibody response healthy individual record tick bites resulted allergic reactions two patients anaphylactic reactions rhipicephalus bursa hyalomma marginatum tick bites patients healthy individual red meat tolerant results supported patient specific ige antibody response tick species responsible anaphylaxis tick bite patients healthy individual serologically recognized tick proteins without alpha gal modifications proteins differentially recognized patients control sera proteins could used potential antigens diagnostics treatment prevention tick bite induced allergies
tightly moored single body floating devices important class offshore wave energy converters examples devices development university uppsala sweden oregon state university usa prototypes recently tested devices equipped linear electrical generator mooring system consists cable kept tight spring equivalent device cable also prevents buoy drifting away providing horizontal restoring force horizontal lesser extent vertical restoring forces nonlinear functions horizontal vertical displacements buoy makes system nonlinear one even spring damper linear whose modelling requires time domain analysis analysis presented preceded comparison purposes simpler frequency domain approach numerical results motions absorbed power shown system consisting hemispherical buoy regular irregular waves tight mooring cable power take modelled simplified system linear spring linear damper also system formed hydraulic piston spring different scenarios analysed elsevier ltd rights reserved
time lost due injury illness requiring rehabilitation major problem activity important part rehabilitation however compliance adherence challenging paper addresses issue presenting automatic system monitoring activity allowing objective assessment activity system consisted smartphone based activity capture platform connected wirelessly back end server analysis storage web server provide user friendly interface feedback education purposes system validated comparison accepted standard measuring devices found match results well system also monitored data participants continuous period number days evident human factors play part data collection strategies authors published elsevier ltd selection peer review responsibility school aerospace mechanical manufacturing engineering rmit university
timing abilities often measured participants tap finger along metronome presenting tap triggered auditory feedback experiments predominantly use electronic percussion pads combined software ftap max msp records responses delivers auditory feedback however setups involve unknown latencies tap onset auditory feedback sometimes miss responses record multiple superfluous responses single tap issues may distort measurements tapping performance affect performance individual present alternative setup using arduino microcontroller addresses issues delivers low latency auditory feedback validated setup participants tap force sensitive resistor pad connected arduino electronic percussion pad various levels force tempi arduino delivered auditory feedback pulse width modulation pwm pin connected headphone jack wave shield component arduino pwm wave shield demonstrated significantly lower auditory feedback latencies percussion pad ftap max msp pwm wave shield latencies also significantly less variable ftap max msp arduino missed significantly fewer taps recorded fewer superfluous responses percussion pad arduino captured responses whereas lower tapping forces percussion pad missed taps regardless tapping force arduino outperformed percussion pad overall arduino high precision low latency portable affordable tool auditory experiments
timing error detection ted based systems shown reduce power consumption increase yield due reduced margins paper shows increased adaptability great advantage system design addition well known mitigated susceptibility ambient internal variations specifically design tolerances power management relaxed enable even greater system level energy savings achieved logic alone addition system simultaneously able operate near minimum error point power management simplified converter ted based time borrowing target application single chip system chip without external discrete components thus switched capacitors used system achieves energy reduction minimum energy point simultaneously energy delay product decrease increase efficiency addition effect local variations average system performance reduced
tio powder modified lif hydrothermal treating lif tio mixed powders powders characterized scanning electron microscopy sem transmission electron microscopy tem vis spectrometry ray diffraction xrd ray photoelectron spectrometry xps hydrothermally treated lif tio powder shown strong absorbability organic dye methylene blue xrd xps results demonstrated existence lif crystals main reason improved absorbability tio charge transfer lif tio could cause obvious polarization interface two materials considered source remarkable enhancement large amount absorption surface tio lif modified tio could used functional material good absorbability area gas sensing dye sensitized solar cells photocatalysts
tissue systems symport antiport rules class distributed parallel computing models inspired cell intercommunication tissues objects never modified process communication changing place within system work variant tissue systems called tissue systems evolutional symport antiport rules introduced objects moved one region another region may evolved process computational power systems studied specifically proved systems one cell using evolutional symport rules length using evolutional antiport rules length turing universal family finite sets positive integers generated systems standard symport antiport rules used moreover cell division rules considered tissue systems evolutional symport antiport rules limit efficiency systems provided evolutional communication rules length computational efficiency kind models shown using evolutional communication rules length elsevier inc rights reserved
titania nanotube tnt powders prepared rapid break anodization rba perchloric acid hclo solution process ethylene glycol mixture hclo water process study prepared calcined tnt powders obtained processes implemented evaluate compare morphology crystal structure specific surface area composition nanotubes longer tnts formed process comparatively larger pore diameter wall thickness obtained nanotubes prepared process tnts obtained process converted nanorods degrees nanotubes obtained process preserve tubular morphology till degrees addition tnts prepared aqueous electrolyte crystalline structure whereas tnts obtained process amorphous samples calcined till degrees xrd peaks anatase phase rutile phase appears degrees tnts prepared processes raman spectra also show clear anatase peaks samples except prepared sample obtained process thus supporting xrd findings ftir spectra reveal presence groups structure tnts obtained processes however presence less prominent annealed samples additionally tnts obtained process carbonaceous impurity present structure attributed electrolyte used process negligible weight loss typical tnts prepared aqueous electrolytes weight loss temperature range degrees found tnts prepared electrolyte process large specific surface area obtained tnts prepared process whereas process produces nanotubes lower specific surface area difference appears correspond dimensions nanotubes obtained two processes
title americans disabilities act prohibits discrimination employment however years later employment rates persons disabilities hover systematic review investigates effectiveness evidence based interventions increase employment people various disabilities forty six articles met inclusion criteria evidence based interventions majority studies assessed interventions persons mental health disabilities strong evidence found ongoing support work related social skills training prior competitive employment persons mental health disabilities moderate evidence supported simulation use assistive technology especially apps cueing peer support increase work participation persons intellectual disabilities neurological cognitive disabilities autism spectrum disorder many strategies increase work participation appropriate occupational therapy intervention suggestions made research specifically looking rigorous evaluation strategies long term
achieve better understanding mechanisms underlying anti asthmatic action inhaled systemic glucocorticoids gcs provide data regarding risk negative effect inhaled gcs cells study conducted effect ciclesonide methylprednisolone effector teff regulatory treg resting trest cells within respiratory extra respiratory tissues mouse model allergic asthma study indicated one possibly key mechanism underlying anti asthmatic action inhaled systemic gcs prevention activation clonal expansion teff cells mediastinal lymph nodes mlns consequently prevents infiltration lungs teff cells beneficial effects gcs asthma treatment mediated increased recruitment treg cells mlns lungs local generation treg cells results demonstrated inhaled systemic gcs induced comparable depletion normal teff trest treg cells mlns head neck lymph nodes peripheral blood furthermore inhaled systemic therapy led loss cells lungs thus study suggests inhaled therapy may safer systemic one respect adverse effect cells present within outside respiratory tract moreover administration inhaled gcs produce negative effects lung residing cells elsevier rights reserved
achieve higher engineering efficiency solar cells group compound semiconductors silicon germanium form thin films containing carbon tin atoms gaining attention alternatives poly silicon crystals atomic configurations atoms near surface thin film analyzed first principles calculation based density functional theory dft results analysis threefold first atoms stable first atomic layer thin film surface affect stability atoms deeper fifth layer second atoms deeper fifth layer affect stability newly arrived atoms surface film growth effects surface interacting atoms thermal equilibrium concentrations layer thin film evaluated consideration degeneracy atomic configurations third case mono doping formation energy surface increases increasing concentration surface case doping concentration ratio formation energies decrease increasing surface concentrations concluded results doping enhances incorporation atoms thin film
achieve long term goals organisms evaluate outcomes expected consequences behaviors unfavorable decisions maintain many symptoms borderline personality disorder bpd therefore better understanding mechanisms underlying decision making bpd needed review current literature comparing decision making patients bpd versus healthy controls analyzed twenty eight empirical studies identified structured literature search effect sizes studies applying comparable experimental tasks analyzed found bpd patients discounted delayed rewards strongly reversal learning significantly altered bpd bpd patients achieved lower net gains iowa gambling task igt current psychotropic medication sex differences age patient control group moderated igt outcome altered decision making variety tasks supported qualitative review summary current evidence supports altered valuation outcomes bpd multifaceted influence decision making adaptive learning reflected literature elsevier ltd rights reserved
address problem low frequency noise internal combustion engine several existing muffler design methods theory quarter wavelength tube helmholtz muffler examined compared paper proposes new type muffler design method advantages quarter wavelength tube helmholtz muffler example carried illustrate analysis original signal design new muffler improvement car noise transmission loss new muffler studied theoretical method finite element method vehicle test new muffler demonstrates excellent performance wider noise elimination frequency band smaller radial size
assess physician attitude towards making oral contraceptives available counter united states assessed physician attitudes towards transition prescription counter availability otc oral contraceptive pills disseminating electronic survey directed primarily residents training obstetrics gynecology obgyn family practice overwhelming majority respondents otc switch combined oral contraceptives among subset respondents primary concern safety overall respondents evenly divided issue otc switch progestin pills opposed cited safety primary concern progestin pills female respondents likely support otc availability obgyn family practice residents opposed otc availability oral contraceptives cite safety primary concern considering abundant evidence overall safety oral contraceptives especially progestin pills appears knowledge deficit among obgyn family practice residents regarding safety oral contraceptives
assess influence ship bank interactions course keeping ability ships planar motion mechanism pmm tests scale model kvlcc tanker conducted circulating water channel cwc different ship bank distances speeds characterize asymmetric hydrodynamic features asymmetric hydrodynamic derivatives defined measured straight towing test centerline displacements change linear hydrodynamic derivatives due ship bank interactions discussed state space equations derived linear equations maneuvering motion include asymmetric hydrodynamic derivatives linear quadratic regulator lqr adopted provide rudder angle variation forward speed course keeping process simulation results varying ship bank separations show lqr suitable classical proportional integral derivative pid controller course keeping kvlcc scenario discussed
clinically contextually implement theoretical factual knowledge care caring developed last years seen great challenge caring science research emphasis put problem solving research methodologies action research hopes narrowing divide caring theory clinical practice thus intention action research towards hermeneutic approach put emphasis hermeneutic application theory praxis become one human dialogue article highlights hermeneutic application research alternative methodology within participatory oriented research presents new opportunity unite clinical practice caring theory aim contribute development hermeneutical application research design epistemological ontological ethical perspective articulating clarifying central foundations application basis gadamer hermeneutical thinking levinas ethical thinking central foundations application research ethics creation hermeneutical room dialogue common understanding appropriation action theoretical understanding turns praxis knowledge also becomes activity theory practice become one application thus realises basic idea praxis theory one thus theory caring become evident implemented clinical practice moments participants find common understanding consensus knowledge care caring
compare thyroid hormone levels septicemic preterm neonates without shock preterm septicemic infants shock constituted group without shock constituted group groups matched gestation postnatal age maternal thyroid disorders thyrotropic medication life expectancy hours excluded compared serum tri iodothyronine thyroxine thyroid stimulating hormone tsh groups univariate multivariate adjusting snappe analysis median iqr tsh significantly lower group group mmol serum also lower group multivariate analysis none measures independently associated septic shock thyroid hormone levels independently predict presence shock among septic preterms
construct interactive graphics graphical user interfaces interactive webpages important matter computer programming purpose imperative programming usually used hand researchers attempting apply constraint programming interactive graphics furthermore paradigm constraint imperative programming proposed position paper reports ongoing work pcp new constraint imperative programming language interactive graphics integrate imperative constraint programming adopt notion events imperative programming notion guards concurrent constraint programming show simple example program language
date information systems research mainly provided monolithic view information technology use considering desired behaviour positive outcomes however given dramatic increase use technology last years susceptibility addiction increasingly becoming important issue technology users researchers paper report results study focuses identifying variations user liability itaddiction reflects susceptibility individual users develop addiction first review literature different disciplines health psychology allows better understand concepts addiction liability addiction literature review also provides overview antecedents consequences associated addiction building analysis depth interviews exploratory open ended surveys collected smartphone users apply concept liability addiction use context propose typological theory user liability addiction typology reveals five ideal types associated user profile addict fanatic highly engaged regular thoughtful building upon extant literature results put forth propositions extend theoretical contributions study finally discuss contributions implications paper research practice
develop silico model predicting percutaneous absorption disposition kinetics chemicals skin layers facilitate design transdermal drug delivery systems skin care products risk assessment occupational consumer exposure general purpose computer model simulating skin permeation absorption disposition kinetics stratum corneum viable dermis dermis developed equations proposed determining partition diffusion properties chemicals considering molecular partition binding mobility skin layers vitro skin penetration data chemicals used validate model observed simulated permeation disposition skin layers compared tested chemicals tested chemicals experimental model results good agreement coefficient determination relative root mean squared error disposition kinetic parameters maximum concentration area curve viable epidermis dermis initially increased hydrophobicity reached maxima decreased increase hydrophobicity considering skin physiological structure composition partition diffusion properties chemicals skin layers determined allows silico simulation percutaneous permeation absorption disposition kinetics wide chemical space model produced results good agreement experimental data chemicals suggesting much improved framework support transdermal delivery drug cosmetic actives well integrated risk assessment
develop novel analgesics side effects less side effects traditional opioids highly demanded treat opioid receptor mediated pain addiction issues recently opioid receptor kor established attractive target although selective agonists could bear heterogeneous pharmacological activities study designed synthesized two new series nepenthone derivatives inserting spacer carbonyl alpha alpha endo ethenylthebaine alpha phenyl substitution skeleton substituting methyl group cyclopropylmethyl group performed vitro tests binding functional assays molecular docking operations newly designed compounds results wet experimental measures modeled binding structures demonstrate new compounds selective kor agonists nanomolar level affinities compound new derivatives showed highest affinity highest selectivity kappa delta kappa toward kor vivo tests revealed compound able induce stronger much longer antinociceptive effect typical kor agonist therefore compound used perfect lead compound future design potent analgesics acting kor
develop quantitative imaging biomarkers synovial tissue perfusion pixel based contrast enhanced ultrasound ceus studied relationship ceus synovial vascular perfusion frequencies pathogenic helper cells psoriatic arthritis psa joints eight consecutive patients psa enrolled study gray scale ceus evaluation performed joint immediately joint aspiration automatic assessment perfusion data using new quantification approach pixel based analysis gamma variate model set perfusional parameters considered time intensity curve includes maximum value peak signal intensity curve blood volume index area curve bvi auc contrast mean transit time mtt direct vivo analysis frequencies ila cells subsets quantified fluorescence activated cell sorter facs cross sectional analyses tested multiple comparison setting false discovery rate common pattern correlations ceus peak auc bvi mtt parameters ila ila ila cells subsets well lack correlation peak auc values cells observed pixel based ceus assessment truly measure synovial inflammation useful tool develop quantitative imaging biomarker monitoring target therapeutics psa
eater demand ever increasing internet traffic keying multi mode fiber expected replaced coherent signaling single mode fiber short reach optical interconnects one key challenges faced receiver end recovery frequency phase transmitter laser propose novel frequency detector uses sine cosine sampling method used carrier phase recovery compensation loop system level simulations proposed detector show promising results
elucidate high temperature plastic deformation creep mechanism materials essential observe dislocation motion tensile loading many reports situ transmission electron microscopy tem observations literature however relationship dislocation motion shear stress steel still clear study order evaluate relationship quantitatively situ tem observations carried conjunction finite element method fem analysis tensile test sample strained elevated temperature inside transmission electron microscope stress distribution strained sample analyzed fem dislocation behavior clearly found depend shear stress shear stress mpa dislocation velocity mobile dislocation density low however high shear stress level mpa caused noticeable increase dislocation velocity mobile dislocation density furthermore article discuss dependence dislocation behavior stress results presented also indicate relationship microstructure strength materials revealed methods used work
empower safe economical eco friendly sustainable solution enhancing oil gas productivity deep water reservoirs new downhole technologies recommended since electric machine plays leading role downhole application squeezing requirement researchers design develop advanced electric machine recent improvement technology uses high temperature magnets permanent magnet flux switching machine pmfsm become one appropriate contenders offshore drilling fewer designed downhole due ambient temperature therefore comprehensive study deals design optimization performance analysis outer rotor pmfsm downhole application preliminary basic design parameters needed machine design calculated mathematically design refinement technique implemented deterministic method finally initial optimized performance machine compared result output torque increase diminishing cogging torque weight respectively therefore concluded purposed optimized design suitable downhole application
enable prosperous internet things iot devices services must extensible adapt changes environment user interaction patterns requirements manifest set design principles layers iot ecosystem hardware cloud services paper gives concrete guidelines learned implementing deploying full stack synergistic iot platform address hardware design concerns present reference platform firestorm upon platform demonstrate firmware personal area networking concerns solutions moving towards larger scales address local service discovery syndication show principles carry global operation security concerns dominate
enable important scientific discoveries eso defined new ground based telescope european extremely large telescope elt baseline design features telescope class primary mirror making largest powerful telescope world consists hexagonal segments wide thick last stages manufacturing process segments nanometre accurate metrology method required within specifications segments measured whiffle tree support structures nanometre level uncertainty total budget form accuracy rms segment assembly paper measurement machine design presented based non contact single point scanning technique capable measuring nanometre accuracy universal fast low operational costs providing suitable metrology segments tactile precision probe implemented able use machine earlier stages segment manufacturing process particular paper describes design air bearing motion system separate metrology system based moving sintered silicon carbide tube fixed zerodur metrology frame interferometric system direct short metrology loop preliminary calculations show nanometre level measurement uncertainty calibration elsevier inc rights reserved
enhance thermal efficiency increase performance internal combustion engine novel concept coupling conventional engine secondary stroke cylinder direct water injection process proposed burned gases working traditional stroke combustion cylinder transferred secondary cylinder expanded even compression exhaust gases pre heated water injected top dead center evaporation injected water recovers heat exhaust gases also increases mass working gas inside cylinder therefore improves overall thermal efficiency model used numerically simulate idea simulations outputs showed bottoming cycle efficient higher engines speeds speccally supercharged turbocharged engine higher exhaust gas pressure reproduce positive work modeled supercharged engine results showed brake thermal efficiency improved brake power
evaluate controlling factors coastline change changjiang yangtze river estuary since extracted mean high tide line multi temporal remote sensing images span year intervals chose scenes constrain changing pattern changjiang estuary coastline implemented gis technology analyze area change changjiang yangtze subaerial delta runoff sediment discharge coastal engineering withal considered analysis coastline changes coastline transgressed seaward since part presents inter annual variations area changjiang subaerial delta increased net accretion rate based change sediment discharge due major projects changjiang river basin divided changing pattern coastline three stages slow accretion stage moderate accretion stage rapid accretion stage liner regression analysis illustrated significantly positive correlation area changes sediment discharge chongming eastern shoal jiuduansha suggested sediment load fundamental effect evolution changjiang estuary construction deep waterway north passage changjiang river led rapid accretion hengsha eastern shoal jiuduansha influencing hydrodynamics north passage coastal engineering reclamation harbor construction also change morphology changjiang estuary defined contribution rate area change assess impact reclamation evolution changjiang estuary turned area increment changjiang estuary attributed reclamation
examine child factors parental characteristics predictors discrepancies parents ratings externalizing internalizing behavior problems sample preschool children adhd behavior problems nonclinical sample investigated correspondence discrepancies parents ratings externalizing internalizing behavior problems broadband scales child behavior checklist version preschool children cbcl parents preschool children adhd behavior problems nonclinical children aged months completed cbcl candidate predictors discrepancy included child age sex parents levels parenting stress depressive mood attention deficit disruptive behavior hierarchical multiple regression analyses conducted correspondence parents ratings internalizing externalizing behavior problems high clinical sample mothers rated severity externalizing behavior problems significantly higher fathers discrepancy fathers mothers externalizing behavior problems predicted child factors interparental differences psychopathology predicted interparental differences parenting stress effect significantly larger nonclinical sample delta parents disagree severity level preschool children externalizing behavior problems clinician take consideration differences parenting stress might involved
examine extent utility scores capture effect mental physical health status life satisfaction older adults retrospective cohort study patients aged years general practices ireland including medical records pharmacy claims self completion questionnaire path analysis used evaluate direct indirect effects chronic disease burden based medications data activity limitation basic instrumental activities daily living anxiety symptoms depressive symptoms hospital anxiety depression scale life satisfaction index via utility score based responses scale utility scores calculated using time trade utility weights covariates included age socioeconomic status final path model fitted data well goodness fit chi direct effects chronic disease burden disability statistically significant excluded final model indicating score mediated total effect direct indirect effects anxiety depression statistically significant size indirect effect small total effect anxiety total effect depression adequately capture effects anxiety depression among older adults suggesting may lead inaccurate assessments effectiveness interventions cohort
explore putative correlation themultilocus sequence types mlst antifungal susceptibility clinical candida tropicalis isolates mainland china eighty two clinical tropicalis isolates collected sixty nine patients ruijin hospital shanghai jiao tong university school medicine shanghai china july february antifungal susceptibility tests performed genetic profiles isolates azole resistant azole susceptible characterised multilocus sequence typing phylogenetic analysis data conducted clustering method using upgma unweighted pair group method arithmetic averages minimal spanning tree algorithm mlst clonal clusters analysed using eburst package six gene fragments identified multilocus sequence typing sapt presented highest typing efficiency whereas sapt least efficient diploid sequence types dsts differentiated dsts genotypes identified new tropicalis dst database twenty dsts assigned seven major groups based eburst analysis group contained dst dst dst dst accounted azole resistant isolates however genetic relationships among azole susceptible isolateswere relatively decentralised mlst analysis putative correlation mlst types antifungal susceptibility clinical tropicalis isolates mainland china shows dsts closely related azole resistant tropicalis clones elsevier rights reserved
explore role testicular leptin jak stat leptin lep jak stat pathway testosterone biosynthesis juvenile stages exercise weight loss male cbl mice randomly divided normal diet high fat diet groups mice high fat diet fed group divided randomly obese control obese moderate volume exercise obese high volume exercise groups mice obese moderate volume exercise group provided day days swimming exercise mice obese high volume exercise group underwent twice amount daily exercise intervention obese moderate volume exercise group results showed high fat diet causes obesity leptin resistance inhibition testicular lep jak stat pathway decreased mrna protein expression steroidogenic factor steroidogenic acute regulatory protein side chain cleavage enzyme decrease serum testosterone estradiol ratio declines sperm quality parameters moderate high volume exercise able reduce body fat increase mrna protein expression lep jak stat moderate exercise significantly increased mrna protein expression steroidogenic factor steroidogenic acute regulatory protein side chain cleavage enzyme significantly reversed serum testosterone estradiol ratio sperm quality parameters findings suggest impairing testicular lep jakstat pathway early stage obesity inhibits biosynthesis testosterone sexual development reduces male reproductive potential long term moderate high volume exercise effectively reduce body fat improve obesity induced abnormalities testicular leptin signal transduction whereas moderate volume exercise reverse negative impacts obesity male reproductive function
facilitate effective assessment stress related bridge performance safety baseline multiscale finite element model corresponding model updating technique required model best represent prototype used well predict global local responses companion paper demonstrates considering modal frequencies alone updating objectives ensure updated multiscale model able predict local stress responses accurately paper presents new updating method uses modal frequencies multiscale displacement stress static influence lines updating objectives paper first explains relationship displacement influence lines mode shapes relationship strain influence lines strain mode shapes formulation multiscale objective functions selection updating parameters presented case study proposed model updating method finally applied multiscale model stonecutters bridge light large number degrees freedom multiscale model response surface method adopted optimization process reduce computation time updated results show proposed model updating technique reduce differences measured computed modal frequencies also measured computed influence lines american society civil engineers
facilitate motion control ironless planar motors stationary circular coils paper real time model proposed predict force torque exerted magnet array force torque calculated lorentz force law essentially expressed calculation volume integral due symmetry circle force torque generated coil change circular coil rotates around axis characteristic significantly utilized calculation volume integral integral real time model calculation independent position rotation angle moving magnet array calculation result numerical integrals considered constants thus real time model paper computed quickly finally experiments carried provide verification proposed real time model computation time model digital signal processor system force torque predicted model rigidly consistent measurement data
harness heterogeneous memory hierarchy advantageous integrate application knowledge guiding frequent memory move replicating migrating virtual memory regions end present memif protected service asynchronous hardware accelerated memory move compared state art page migration linux memif incurs low overhead low latency order redefines semantics kernel interface also overhauls underlying mechanisms including request completion management race handling dma engine configuration implement memif linux server class system chip features heterogeneous memories compared current linux page migration memif reduces cpu usage small pages large pages continuously serving requests memif need request batching reduces latency crafting small runtime atop memif improve throughputs set streaming workloads overall memif opened door software management heterogeneous memory
identify diagnostic markers psoriasis vulgaris psoriatic arthritis autoantibodies sera patients psoriasis screened two dimensional immunoblotting previously found autoantigens psoriasis sera study serum levels valosin containing protein vcp patients one identified autoantigens psoriasis patients studied reverse phase protein array analysis using sera patients psoriasis healthy controls serum levels vcp significantly higher patients psoriatic arthritis controls patients psoriasis vulgaris area curve vcp patients psoriatic arthritis controls psoriatic vulgaris patients respectively serum level vcp weakly correlated disease activity psoriasis patients psoriasis area severity index score data suggest vcp novel differential sero diagnostic marker psoriatic arthritis
increase software performance common use hardware accelerators currently gpus widespread accelerators handle general computations requires use gpgpu frameworks cuda opencl low level make benefit gpgpu programming difficult achieve particular require write programs combination two subprograms manually manage devices memory transfers increases complexity overall software design idea develop paper guarantee expressiveness safety cpu gpu computations memory managements high level data structures static type checking paper present statically typed languages compilers libraries help harness high level gpgpu programming particular show added high level user defined data structures gpgpu programming framework based statically typed programming language ocaml thus describe introduction records tagged unions shared host program gpgpu kernels described via domain specific language well simple pattern matching control structure manage examples practical tests comparisons state art tools show solutions improve code design productivity safety providing high level performance
investigate contributions genetic environmental risk factors possible direction causation relationship symptoms cannabis use disorders cud psychotic like experiences ples population based sample young adult twins female mean range age assessed symptoms cud ples using composite international diagnostic interview latent risk symptoms cud ples modeled using item response theory twin control analysis performed investigate effect familiar confounding association symptoms cud ples biometric twin models fitted estimate heritability genetic environmental correlations direction association lifetime use cannabis reported twins prevalence ples ranged incidence rate ratio ples due symptoms cud total sample within twin pairs heritability estimates symptoms cud men women ples men women genetic environmental correlations symptoms cud ples respectively model allowing symptoms cud cause ples better fit models specifying opposite reciprocal directions causation association symptoms cud ples explained shared genetic environmental factors direct effects cud risk ples
investigate additive systemic inflammatory process rheumatoid arthritis arterial hypertension patients structural morphological changes retina optic nerve head assessed modern topographic technologies similarities underlying vascular mechanisms arterial hypertension interesting researched depth aim study evaluate changes arterial hypertension optic coherence topography oct heidelberg retina tomography hrt iii validate changes comparison arterial hypertension patients finally methods useful detect chronic inflammatory influence eye prospective study design data patients arterial hypertension years old positive antibodies cyclic citrullinated peptides patients arterial hypertension years old healthy subjects years old included intensive ophthalmologic internistic screening tests carried subjects participants investigated retinal nerve fiber layer rnfl macula thickness oct carl zeiss germany stereometric parameters optic nerve head heidelberg retina tomograph iii heidelberg engineering germany pachymetry conducted orbscan system bausch lomb statistical data assessed spss significant differences found visual function diastolic systolic blood pressure rnfl macular thickness stratus oct almost consistent groups even main stereometric parameters measured hrt iii showed significant differences contrary study hypothesis structural morphological changes could detected patients arterial hypertension without compared healthy subjects furthermore specific effects could shown comparison hypertension group thus used examination techniques suitable prove systemic inflammatory influence eye
investigate reflective crack propagation behavior provide control techniques asphalt pavements widening finite element models built simulate widened asphalt pavement latent joint developed finite element model considered influence factors including loading modes symmetrical unsymmetrical loading modes thickness modulus asphalt concrete surface modulus new existing stabilized bases sheet stiffness reinforced geosynthetic finite element simulation results show increasing thickness reducing modulus asphalt concrete surface effectively delays propagation speed reflective cracks cracking potential reaches minimum new existing bases uniform modulus additionally geosynthetic reinforcement across joints significantly reduces stress concentration around crack tip slows propagation reflective cracks benefits become greater increasing sheet stiffness geosynthetic finally experimental study conducted investigate influence types asphalt overlay geosynthetic reinforcement reflective crack propagation behavior experimental results indicate geosynthetic reinforced structure lower modulus asphalt concrete surface significantly increases fatigue life widened pavements polypropylene geotextile performs better glass fiber grid terms extension fatigue life
investigate value second opinion evaluation multiparametric prostate magnetic resonance imaging mri subspecialised uroradiologists tertiary centre detection significant cancer transperineal fusion prostate biopsy evaluation prospectively acquired initial second opinion radiology reports patients underwent mri regional hospitals prior transperineal untrasound fusion biopsy tertiary referral centre year period gleason score cancer positive predictive value ppv negative npv predictive value confidence intervals calculated compared fisher exact test disagreement initial tertiary centre second opinion reports observed cases mris higher npv tertiary centre reads compared initial reports higher ppv target area cancer cancer equivocal suspicion ppv tertiary centre initial reads second readings prostate mri subspecialised uroradiologists tertiary centre significantly improved npv ppv reporter experience may help reduce overcalling avoid overtargeting lesions aeuro cent multiparametric mris often called negative subspecialist reads aeuro cent second readings prostate mpmris subspecialist uroradiologists significantly improved npv ppv aeuro cent reporter experience may reduce overcalling avoid overtargeting lesions aeuro cent greater education training radiologists prostate mri interpretation advised
manage electrical network stationary application embedded application hybrid electrical vehicles necessary understand model electrical behaviour sources board paper deals characterization supercapacitors electrical power sources order model three equivalent electrical circuit models supercapacitor proposed corresponding different levels modelling identification model parameters carried adapted characterization tests charge discharge test constant current electrochemical impedance spectroscopy environmental constraints experimental results compared analysed many characterizations different test conditions terms voltage temperature degrees frequency mhz khz many supercapacitor cells several capacitances two suppliers maxwell batscap elsevier rights reserved
manoeuvre complex societies beneficial acquire knowledge social relationships existing among group mates better predict behaviour although knowledge firmly established variety animal taxa animals acquire knowledge well functional significance remains poorly understood order understand primates acquire use social knowledge studied kin biased redirected aggression japanese macaques macaca fuscata relying large database aggressive episodes confirming previous research macaques redirected aggression preferentially kin aggressor analysis controlled rate affiliation aggressors targets redirection showed macaques identified relatives group mates basis frequency ongoing associations contrast observed group mates interact mother infants increase monkeys success correctly identifying kin relationships among third parties inter individual variation successful identification kin aggressors redirecting aggression accordingly translated differences amount aggression received highlighting selective advantage individuals better able acquire use social knowledge
perform joint analysis multivariate neuroimaging phenotypes candidate genetic markers obtained longitudinal studies develop bayesian longitudinal low rank regression model model integrates three key methodologies low rank matrix approximating high dimensional regression coefficient matrices corresponding genetic main effects interactions time penalized splines characterizing overall time effect sparse factor analysis model coupled random effects capturing within subject spatio temporal correlations longitudinal phenotypes posterior computation proceeds via efficient markov chain monte carlo algorithm simulations show model outperforms several competing methods apply model investigate effect single nucleotide polymorphisms snps top top previously reported alzheimer disease associated genes also identify associations interactions snps patient age tissue volumes regions interest patients brain images obtained alzheimer disease neuroimaging initiative
predict network security situations better using expert knowledge quantitative data new forecasting model known cloud belief rule base cbrb model proposed cbrb model utilizes cloud model describe referential point belief rule accurate describing expert knowledge moreover achieve optimal parameters proposed model constraint covariance matrix adaptation evolution strategy cma algorithm presented letter case study network security situation prediction conducted cbrb cma experimental results demonstrate effectiveness practicality proposed cbrb model
promote energy efficient operations residential office buildings non intrusive load monitoring nilm techniques proposed infer fine grained power consumption usage patterns appliances power line measurement data fine grained monitoring everyday appliances toasters coffee makers promote energy efficient building operations also provide unique insights context activities individuals current building level nilm techniques unable identify consumption characteristics relatively low load appliances whereas smart plug based solutions incur significant deployment maintenance costs paper investigate intermediate architecture smart circuit breakers provide measurements aggregate power consumption room section level granularity investigate techniques identify usage energy consumption individual appliances measurements first develop novel correlation based approach called cbpa identify individual appliances based unique transient steady state power signatures promising cbpa fails set candidate appliances large improve accuracy appliance level usage estimation propose hybrid system called aarpa uses mobile sensing first infer high level activities daily living adls uses knowledge adls effectively reduce set candidate appliances potentially contribute aggregate readings point evaluate two variants algorithm show using real life data traces gathered domestic users fusion mobile power line sensing promising identified devices used data trace identified usage duration energy consumption low load consumer appliances similar accuracy elsevier rights reserved
reduce fuel consumption exhaust emissions hybrid electric vehicles hevs important develop well organized energy management system ems paper proposes torque control strategy coupled optimization parallel hev torque control strategy developed first particular function control driving condition called internal combustion engine ice torque control function introduced function controls driving conditions electric motor driving ice driving ice driving assisted reducing fuel consumption exhaust emissions function depends several design variables optimized numerical simulation hev using matlab simulink computationally intensive sequential approximate optimization sao using radial basis function network rbf adopted determine optimal values design variables result optimal ice torque control function determined small number simulation runs paper nox emissions minimized simultaneously reducing fuel consumption exhaust emission numerical simulations using typical driving cycles trade nox emissions clarified validity proposed torque control strategy coupled proposed optimization examined
response increasing demands clean water large pressurized water reactor pwr desalination capability studied demonstrated potential far however electricity production large nuclear reactor decreases due steam bypass desalination study authors evaluate possibility large pwr capability producing electric power clean water using supercritical brayton cycle technology power technology adopted minimize decrease electricity production capacity due desalination process two concepts replace existing steam based power conversion system brayton cycle proposed first concept low pressure steam turbine section power conversion system replaced brayton cycle second concept whole steam based power conversion system replaced brayton cycle several cycle options considered terms power production desalination capacity conducted comparative analysis selected layouts optimal operating conditions suggested layouts identified elsevier rights reserved
retrospectively review post treatment post fdg pet scans patients advanced head neck squamous cell carcinoma hnscc known status treated definitive chemo radiation total eligible patients greater hnscc treated chemort august february post pet within months kaplan meier curves log rank statistics cox proportional hazards regression used statistical analysis median follow years sixty eight patients status two year overall survival recurrence free survival respectively negative predictive value npv pet local recurrence npv regional recurrence patients patients patients positive predictive value ppv pet recurrence patients ppv patients patients patients ppv patients post pet status independent predictors recurrence free survival post pet predicts treatment outcomes patients independently status patients negative pet risk nodal recurrence closer follow patients warranted
reveal whether organic mixtures perform better aspect matching two heat sources different grades paper presents dual loop system waste heat recovery internal combustion engine two heat sources different temperature high temperature loop water working fluid employed recover waste heat engine exhaust gas low temperature loop organic mixtures butane ryf rfa selected working fluids recover heat jacket cooling water heat released condensation process high temperature loop organic mixtures low temperature loop present better system performance pure working fluids better temperature matching condensation better matching two heat sources different grades influence high temperature loop condensing temperature whole system also analyzed research simulation results reveal appropriate mixture improve thermal efficiency also absorbed heat heat sources low temperature loop ryf working fluid low temperature loop engine output improved nearly elsevier ltd rights reserved
seek proper way calculate preoffsetting value saddle suspension bridge influences structural parameters preoffsetting considered new method preoffsetting value saddle proposed basis relationship main cable saddle equilibrium equations geometric equations physical equations deduced equations solved newton raphson iteration method derive jacobian influence matrix preoffsetting convergence numerical calculation constraint conditions range initial values given comparison measured value scale model test calculated value reliability new method confirmed finally parametric analysis preoffsetting shows increase saddle radius saddle preoffsetting increases middle span direction increases side middle span rise span ratios saddle preoffsetting increases side span direction influence cable self weight saddle preoffsetting negligible increase unstressed cable length side span saddle preoffsetting increases middle span direction increase unstressed cable length middle span saddle preoffsetting increases side span direction
tobacco smoking one risk factors upper aerodigestive tract cancer exclusive quantification impact cigarette smoking laryngeal cancer investigated meta analysis researches reported quantitative estimates cigarette smoking risk laryngeal cancer march performed pooled estimates relative risks confidence intervals obtained summarized sensitivity analysis subgroup analysis implemented find sources research heterogeneity effect potential confounders publication bias investigated corrected found present egger begg test trim fill algorithm thirty researches based total cases three cohort fifteen case control studies included pooled estimate correlation cigarette smoking risk laryngeal cancer confidence interval moderate heterogeneity across researches rrs cohort studies case control studies risk kept elevated within first fifteen years quitting smoking dropped years smoking cessation individuals smoked pack years nine times risk laryngeal cancer subjects smoked cigarettes day sevenfolds risk laryngeal cancer smoked years five times risk versus never smokers evidence publication bias detected correlation current cigarette smoking risk laryngeal cancer begg test egger test results demonstrated strong correlation referring dose response time response cigarette smoking risk laryngeal cancer men women probability developing laryngeal cancer decreased quitting smoking particularly among former cigarette smokers stopped smoking years subgroup analysis demonstrated study type influenced rrs estimates studies
tobacco use leading cause preventable death united states exposure tobacco smoke harms children conception forward safe level tobacco exposure although overall smoking rates declined advent new products electronic cigarettes threatens perpetuate nicotine addiction without clear health benefits addition reviewing traditional new tobacco products discuss unique role pediatricians play tobacco treatment control efforts new policies technologies empower pediatric clinicians pediatric health care sys tems help parent smokers quit new policies outside health care setting might help prevent smoking initiation well improve cessation treatments future research needed continue study consequences tobacco use exposure well best ways help patients parents stop tobacco use
today dns servers run many different applications operating systems means many options protect dns server regular application implemented security mechanisms protect system standard attacks dns service works application layer however possible prevent many threats already lower layers paper deals dns security mechanisms applicable transport network layer proposed protection technique based traffic shaping flow filtering prioritization presented experiments performed subarea real campus network used students university staff implemented security mechanisms performance dns service internal users affected
today many different devices operating systems used infovis systems one hand web based visualizations used compatible several systems performance depends optimized browser engines hand possible build native system supports benefits one device however transferring code another system means parts code programming language adapted close gap present proof concept based unityd game engine implemented prototype following infovis reference model basic interactions interactive data exploration major advantage ability deploy native code different devices additionally proof concept opens new possibilities future infovis framework benefits unityd
today reconstruction faces actual task used various fields example scientific research recognition video games movie industry one existing methods reconstructing models faces uses stereo cameras reconstruction process usually consists several steps calibration cameras acquiring depth map disparity map creation model paper method acquiring depth map proposed later used reconstruction model face proposed method tested virtual environment editor autodesk max used create virtual scene containing stereo cameras human head proposed method also tested using two visar cameras arduino micro microcontroller arduino software allows ensure synchronization cameras using arduino micro microcontroller images captured cameras using flycap program since initial images contain distortions first step algorithm calibrations cameras calibration similar points found stereo images points later used calculate degree distortion images rectified accordingly rectified images used calculate depth map depth map created front half tone images faces authors published elsevier
today many forms art influenced emergence interactive technologies including mixing physical media digital technology forming new hybrid works art usage mobile phones create art projected public spaces many artists painters use digital technology augment work technically creatively context many believe time transition traditional analogue art post modern digital art art grounded codes rather images arrived http www artnet com magazineus features kuspit kuspit asp research work described paper contributes towards supporting use ambient intelligence technologies traditional painters creativity well methods techniques art masters paper presents design implementation intelligent environment software infrastructure form digitally augmented art workshop practical exploitation conducted ambient intelligence ami simulation space four feasibility studies conducted studies oil painting created following alternative yet accredited artists approach
today millions users world visit websites using smartphones mobile devices several features may contribute worsen user experience using mobile webs small displays virtual keyboards poor precision select elements using finger cursor addition mobile web peculiar feature always used place situations many cases environmental factors adversely affect user experience using web application adverse situations derived ambient may different noise pollution excess light able see well letters walking etc research presents novel mobile web paradigm allows adaptation web applications depending environment proposed solution introduces novel mobile web browser based principles ambient intelligence ami web browser uses smartphone hardware elements sensors microphones capture environmental information intelligently analyzed detect events situations identified situations communicated web application appropriate adaptation made improve user experience
today php one popular programming languages commonly used open source community industry build large application frameworks web applications paper discuss ongoing work php air framework php analysis rascal php air focused especially program analysis empirical software engineering used actively effectively work evaluating php feature usage system evolution program analysis refactoring security validation source code metrics describe requirements design decisions php air summarize current research using php air discuss lessons learned briefly sketch future work elsevier rights reserved
today relational databases used store structured complex data consist multiple relations linked together conceptually via entity relationship links need analyze complex structured data increased many traditional learning techniques mine single table input could meet requirement multi relational data mining methods proposed search useful patterns involved multiple relations relational database classification one popular tasks data mining numerous studies done solving multi relational classification problems due variety plenty proposed methods field seems useful understand better classification methods differences work provide analysis focuses relational upgraded methods upgrade traditional supervised classification algorithms knn naive bayesian decision tree genetic algorithms multi relational classification classify methods according traditional methods upgraded review analyze existing multi relational classification techniques group therefore study presents formal classification analysis provides useful roadmap new researchers area multi relational classification
today complex fast evolving world necessitates young students possess design problem solving skills ever one alternative method teaching children problem solving thinking skills using computer programming recently game design tasks pre experimental study group middle school students age average attended game design summer program days students assessed problem solving skills specifically system analysis design decision making troubleshooting domains beginning end program results indicated significant improvements students problem solving skills attending summer program wilks eta system analysis design decision making follow tests pointed large medium effect sizes troubleshooting gains significant study contributes growing body literature investigating benefits designing games young children adding game design activities suitable venues young children learn practice problem solving skills
today internet makes hosts individual networks inherently insecure permanent addresses turn destinations permanent attack targets paper describes evasive internet protocol eip change data plane internet prevents senders forging identities preserving current internet privacy paradigm gives recipients full control communicate long achieves features without requiring global signaling protocols allows coexistence graceful introduction current internet motivate approach present architectural design evaluate trace driven synthetic simulations well prototype testing
today trend replacing manually operated vehicles automated ones impact machine design working environment procedures also machine breakdown maintenance procedures harsh environment underground mines transition manual automatic operation believed fundamentally change basis break downs maintenance machine design paper differences similarities manual automatic underground loading equipment analysed reliability point view analysis based case study performed swedish underground mine contrary common thoughts paper proves difference manual semi automatic machines particular transmission favour manual one paper also shows path detailed reliability analysis results may used improving maintenance programmes types mobile equipment copyright john wiley sons ltd
tools based multivariate statistical analysis becoming popular automatically revealing existence damage structures using vibration data changing environmental operational conditions typically temperature humidity traffic intensity paper methods multivariate statistical analysis newly applied monitoring structural health state main cables suspension bridges main contribution removing non linear aeroelastic correlations dynamic features wind speed considering natural frequencies damage sensitive features analytical parametric model suspension bridge damage one main cable subjected wind loading formulated first extension previous work model predictions demonstrate apparent frequency variations caused changes incoming wind speed likely significant produced small damage technique based principal component analysis novelty detection adopted cope issue application long term pseudo experimental buffeting response data generated means analytical model presented results demonstrate feasibility permanent monitoring systems reveal existence damages wind excited long span bridges producing relative variations sensitive natural frequency smaller elsevier ltd rights reserved
topical systemic therapies erythema multiforme widely described literature pathogenesis erythema multiforme involves increased expression vascular endothelial growth factor resulting promotion microvascular permeability angiogenesis gentian violet shown antiangiogenic properties present case erythema multiforme successfully treated topical gentian violet report case patient presented erythema multiforme prior pertinent history included diabetes mellitus type limiting clinical use systemic corticosteroids topical gentian violet used treat cutaneous lesions patient responded well treatment topical gentian violet stabilization resolution lesions without using systemic therapy may pose serious side effects setting comorbidities diabetes mellitus type case highlights variable therapeutic options available treatment erythema multiforme including topical gentian violet studies needed case demonstrates antiangiogenic properties clinical utility topical gentian violet treatment erythema multiforme
topiramate tpm effective multiple seizure types epilepsy syndromes children adults topiramate adverse effects including cognitive depression renal stones many low incidence started low dose slowly titrated day also tpm proven benefit migraine obesity eating disorders alcohol use disorders comorbid patients epilepsy may also effective subpopulations within specific psychiatric diagnoses recently approved extended release formulations tpm trokendi qudexy united states reliable data supporting safety efficacy patients epilepsy potential rapid titration within month day better patient retention tpm immediate release robust double blind randomized controlled trials comparing different formulations expect per day extended release formulations improve medication adherence compared twice per day formulations significant potential improve outcomes epilepsy tpm responsive disorders
topological techniques powerful tools characterizing complexity many dynamical systems including commonly studied area preserving maps plane however extension many topological techniques higher dimensions filled roadblocks preventing application article shows extend homotopic lobe dynamics hld technique previously developed two dimensional maps volume preserving maps phase space maps physically relevant particle transport incompressible fluid flows magnetic field lines specifically manuscript shows utilize stable unstable invariant manifolds intersecting heteroclinic tangle construct symbolic representation topological dynamics map symbolic representation used classify system trajectories compute topological entropy illustrate salient ideas series examples increasing complexity examples highlight new features hld technique three dimensions ultimately final example technique detects difference stretching rate surfaces stretching rate curves illustrating truly nature approach
torch maneuver skills possessed skilled welder typically require long time develop machine assisted feedback control system stabilize welder movement would thus interest manufacturing industry paper interval model based feedback control system designed assist welder adjust torch movement tracking desired speed manual gas tungsten arc welding gtaw process end innovative helmet based manual welding platform utilized system vibrators installed helmet generate vibration sounds instruct welder speed slow torch movement torch movement monitored leap motion sensor torch speed used feedback control algorithm determine change vibrations design control algorithm dynamic experiments conducted correlate arm movement torch speed vibration control signal linear models first identified corresponding linear parameter intervals obtained interval model control algorithm implemented simulation results reveal proposed interval model control algorithm outperforms traditional proportion integration differentiation pid controller experiments verified welder speed controlled acceptable accuracy
tourist host social contact unique type social contact getting sufficient attention tourism academia considering remarkable impacts tourists travel attitudes behaviors long term perceptions objectives current study explore dimensions tourist host social contact contribute theory tourist typology according dynamic nature tourist host social interaction forty five depth interviews conducted generate insightful information software nvivo applied examine code transcripts result six dimensions adopted describe tourist host social contact purposes determinants activities intensity impacts attitudes five types tourists pinpointed theoretical practical contributions study discussed elsevier ltd rights reserved
toxoplasma gondii pathogen relevant psychiatric disorders recently showed reactivation chronic gondii infection induced depression like behaviors mice furthermore hypothesized depression like behaviors mediated via host defense mechanism invading pathogens proximate mechanisms behavioral hypothesis remain unclear present study investigate contribution indoleamine dioxygenase ido inflammation interferon gamma ifn gamma anhedonic despair related behaviors gondii infected mice using sucrose preference forced swim tests respectively first confirmed balb mice exhibited sickness depression like behaviors acute infection treatment infected wild type mice minocycline anti inflammatory drug abated sickness anhedonic despair like behaviors whereas gondii infected mice treatment normalized kynurenine tryptophan kyn trp ratios plasma brain tissue additionally gondii infection failed induce anhedonic despair like behaviors increase kyn trp ratio immunocompromised ifn gamma mice whereas sickness behavior observed immunocompetent ifn gamma mice following infection furthermore treatment methyl tryptophan ido inhibitor affect locomotor activity attenuated clinical scores anhedonic despair like behaviors resulted normal kyn trp ratios gondii infected wild type mice although low levels serotonin dopamine observed brain acute chronic infections anhedonic despair like behaviors detected chronic stage infection collectively results demonstrated immune enhancement response infection gondii resulted ifn gamma production ido activation inflammation associated anhedonic despair like behaviors
gene mutations occurring patients myelodysplastic syndrome mds acute myeloid leukemia aml associated high risk karyotypes including abnormalities monosomal complex cytogenetics mutations disorders portend rapid disease progression resistance conventional therapeutics notably size mutant clone measured mutation allele burden directly linked overall survival confirming importance negative prognostic variable nucleolar stress induced ribosomopathies del mds disassociation mdm results accumulation erythroid precursors manifested erythroid hypoplasia antagonism lenalidomide therapeutics antisense oligonucleotides repopulates erythroid precursors enhances effective erythropoiesis findings demonstrate intriguing therapeutic target currently investigation mds aml study reviews molecular advances understanding role mds aml explores potential therapeutic strategies era personalized medicine
traction motor design significantly differs industrial machine design starting point load cycle instead steady state rated operation point speed motor varies zero high speeds low speeds heavy overloading used starting field weakening region also plays important role finding suitable field weakening point one important design targets lowest speeds high torque output desired current reserves supplying converter unit used achieve torque paper starting torque maximum speed permanent magnet traction motor studied field weakening point altered varying number winding turns machine one design selected prototyping theoretical results verified measurements
traditional control charts hotelling effective detecting abnormal patterns however control charts take account time varying property process present study propose parameter less self organizing map based control chart handle situation changes occur distribution parameter target observations control limits proposed chart determined estimating empirical level significance percentile using bootstrap method experimental results obtained using simulated data actual process data manufacturing process thin film transistor liquid crystal display demonstrate effectiveness usefulness proposed algorithm elsevier ltd rights reserved
traditional methods monitoring environmental factors greenhouse growth phalaenopsis orchids often suffer low spatiotemporal resolution high labor intensity requiring much time lack automation synchronization solve problems study develops internet things iot based system monitor environmental factors orchid greenhouse growth status phalaenopsis time whole system consists iot based environmental monitoring system iot based wireless imaging platform image processing algorithm based canny edge detection method seeded region growing srg method mathematical morphology also developed estimate leaf area phalaenopsis long term experiments respect four different environmental conditions cultivating phalaenopsis conducted statistical analysis methods including one way anova two way anova games howell test performed examine relation growth phalaenopsis leaves environmental factors greenhouse optimal cultivation conditions phalaenopsis easily identified experimental results indicate daily average growth rate leaf area phalaenopsis approximately day temperature relative humidity greenhouse controlled degrees respectively proposed system shows great potential provide quantitative information high spatiotemporal resolution floral farmers promisingly expected proposed system effectively contribute updating farming strategies phalaenopsis future elsevier rights reserved
traditional based operating systems load components boot process along kernel mechanism though effective broader objective seldom utilized fully majority users usually perform specific job require every component observed operating systems designed keeping mind nature job achieve better performance standard systems even inferior hardware sony playstation gives better performance per watt compared similar graphics configuration prime cause weak performance wasting resources due generic purpose design paper proposes novel technique enable efficient utilization hardware many choices available user choice corresponds different mode operation achieved using modular shell design wherein resource deployment done according requirements module uniform base module allow easy fast access user allowing perform basic tasks module operating system shall loaded perform specific task provide user enhanced access perform job user switch among modules according requirements also allow specific components kernel allocate resources according needs program mechanism provide benefits real time time shared environment allow coordinated control resources possible traditional unix based operating system
traditional treatment sports injuries includes use price principle protection rest ice compression elevation nonsteroidal anti inflammatories physical therapy modalities corticosteroid injections recent evidence raised concerns traditional treatment approach regarding use anti inflammatories injectable corticosteroids recent treatments known regenerative medicine include platelet rich plasma stem cell therapies evidence efficacy variety sports injuries emerged ranging tendinopathy muscle tears ligament chondral injuries article reviews literature regarding established treatments sports injuries innovative treatments
traditional water distribution irrigation systems used middle east agriculture thousands years main objectives study investigate positive negative environmental social impacts traditional methods three countries mediterranean sudan yemen palestine achieve objectives field visits observations interviews questionnaires used results showed presence five main traditional water distribution systems three areas differences existing systems attributed farmers education level experience degree water scarcity area educated farmers experienced farmers water scarcity areas adopting modern irrigation techniques especially palestine preserving existing natural habitat strengthening social ties relations farmers among positive environmental impacts old methods water losses high evaporation water loss seepage water pollution among negative impacts proper planning control especially public institutions programs environmental awareness necessary actions minimize negative impacts traditional water societies suggested measures specifically important adopted whenever modern methods water distribution pipelines irrigation drip irrigation intended applied
traditionally production control construction sites challenging still remains challenging hoc production control methods usually used informal foster uncertainty prevents smooth production flow lean construction methods last planner system partially tackled problem involving site teams decision making process report back production management system however systems relatively long lookahead planning cycles respond dynamic production requirements construction daily hourly control needed new solutions proposed visilean kanbim etc types construction management systems require proximity availability computer devices workers paper authors investigate communication framework underlying construction management systems improved fully partially automate various communication functions across construction project lifecycle enable lean close real time reporting production control information end present paper provides evidences internet things iot related standards contribute improvement paper provides first insights various construction scenarios proposed communication framework beneficial various actors core business perspectives lean construction management management entire building lifecycle elsevier rights reserved
traffic congestion growing problem many countries around world recognized instead constructing roads freeways counter problem prudent improve utilization existing road network judicious combination advances control engineering communication information technology traffic control architecture proposed paper combination communicating urban traffic control architecture utca freeway traffic control architecture ftca utca combines context awareness cyber physical systems cps principles autonomic computing system acs principles optimize traffic congestion enforce safety urban traffic network utca includes network adaptive intersection traffic controllers immediate supervisory systems also networked central piece traffic controller arbiter mini cps aware traffic dynamics intersection managed virtue continuous input monitoring sensors due context awareness ability communication ability exchange traffic information neighbors execute policy based reactions order enable safe efficient traffic throughput intersection urban traffic supervisory system designed acs principles order minimize downtime caused environmental emergencies maximize security subsystem supervisory subsystem also collect global traffic flow information contextual constraints neighbors based input modify policies communicate traffic controller timely adaptation urban traffic flowing freeway traffic mediated intelligent ramp meters irm irm interacts urban traffic control system nearest intelligent roadside unit irsu regulate flow traffic urban freeway network ftca consists network mutually interacting irsus monitor traffic flow communicate irms providing traffic guidance freeway drivers irsu communicate vehicles zone managed order provide information rerouting road weather conditions warrant also facilitates exchange information vehicles guide lane changes maintaining safe distance order avoid collision
traffic flow cities affected numerous factors including land use especially commercial land use trip making nature phenomenon effective combined accessibility factors street connectivity case bojnourd selected study important reason choose case municipality gives commercial construction permits developers city without paying attention traffic consequences bojnourd medium sized city capital north khorasan province ultimate goal study determine effectiveness commercial land use route configuration number trips purpose analysis secondary data used method study findings showed significant relationship commercial land use trip volume bojnourd city findings also indicated strong correlation syntax routes traffic flow case bojnourd combined effect commercial land use route configuration number trips examined factors influence number trips significant american society civil engineers
traffic related air pollution trap associated lower cognition reduced white matter volume older adults specifically particulate matter diameter rodents exposed trap shown microglial activation neuronal atrophy investigated age differences trap exposure focus hippocampus neuritic atrophy white matter degeneration microglial activation young middle aged mice months female cbl exposed nanoscalepm npm diameter young mice showed selective changes hippocampal region neurite atrophy decreased mbp increased iba dentate gyrus relatively unaffected exposure npm young mice decreased glua protein increased tnfa mrna older controls age changes approximating npm effects young response npm suggesting age ceiling effect selective vulnerability young mice parallels vulnerability alzheimer disease propose trap associated human cognitive white matter changes involve hippocampal responses npm begin younger ages elsevier inc rights reserved
training anatomic clinical pathology residents principles bioinformatics challenging endeavor residents receive little formal exposure bioinformatics medical education pathology training spent interpreting histopathology slides using light microscopy focused laboratory regulation management interpretation discrete laboratory data minimum residents familiar data structure data pipelines data manipulation data regulations within clinical laboratories fellowship level training incorporate advanced principles unique subspecialty barriers bioinformatics education include clinical apprenticeship training model ill defined educational milestones inadequate faculty expertise limited exposure medical training online educational resources case based learning incorporation molecular genomics education could serve effective educational strategies overall pathology bioinformatics training incorporated pathology resident curricula provided motivation incorporate institutional support educational resources adequate faculty expertise
transcranial direct current stimulation tdcs non invasive form brain stimulation uses weak constant current alter cortical excitability activity temporarily tdcs induced increases neuronal excitability performance improvements observed following anodal stimulation brain regions associated visual motor functions relatively little research conducted respect auditory processing recently pilot study results indicate anodal tdcs increase auditory deviance detection whereas cathodal tdcs decreases auditory processing measured brain based event related potential erp mismatch negativity mmn evidence shown tdcs lasting effects may dependent methyl aspartate nmda receptor activity current study investigated use dextromethorphan dmo nmda antagonist assess possible modulation tdcs effects mmn working memory performance study conducted healthy volunteers involved four laboratory test sessions within randomised placebo sham controlled crossover design compared pre post anodal tdcs auditory cortex minutes excite cortical activity temporarily locally sham stimulation device turned dmo placebo administration anodal tdcs increased mmn amplitudes placebo administration significant increases seen sham stimulation anodal stimulation dmo administration sham stimulation stimulation dmo decreased mmn amplitudes findings study contribute understanding underlying neurobiological mechanisms mediating tdcs sensory memory improvements
transcription regulation temporal conditional manner underpins lifecycle enterobacterial pathogens upon exposure wide array environmental cues pathogens modulate gene expression via rna polymerase associated sigma factors different sigma factors either involved general house keeping specific responses guide rna polymerase cognate promoter dnas major alternative sigma factor activated helps pathogens manage stresses proliferate ecological niches chapter review function regulation sigma dependent phage shock protein psp system major stress response gram negative pathogens encounter damages inner membranes discuss recent development mechanisms gene regulation signal transduction stress mitigation light different biophysical biochemical approaches
transferable skills vital modern engineering work educational institutions forced reassess education along theoretical content transferable competences emphasized paper demonstrates teaching transferable skills team work oral writing skills project time financial management integrated single course also show motivate students interactive teaching methods course evaluation
transforming sloping land terraced land effective approach cope problems including farmland shortage severe soil erosion paper introduces new system based rainwater harvesting recycling technology may effectively improve farmland productivity rainwater use efficiency reduce water fertilizer inputs new system consists three subsystems plough layer dual function crop cultivation rainwater harvesting tank plough layer storing water irrigation drainage subsystem plough layer storage tank treated reducing seepage connected irrigation drainage system results showed compared traditional paddy fields rice evapotranspiration crop coefficient test field remained similar level irrigation amount reduced condition basin irrigation drainage amount decreased non point source pollution reduced similar rainwater utilization efficiency increased reached crop yield middle season rice reached lower traditional paddy field terms dry matter new technology sheds light new possibilities transformation hilly sloping land
transient hydraulics always characterizes circulating flow managed pressure drilling therefore application godunov scheme oil well drilling hydraulics presented numerical model developed describes treatment process initial boundary conditions well geometry true operational conditions well known finite volume method riemann problem utilized building set discrete equations account godunov simulation describes profiles transient pressure transient flow rate along well attending oil field engineering concerns drilling parameters discussed follows choke pressure pumping pressure bottom hole pressure circulating flow rate comparison computed well data results show small difference less pumping bottom hole pressures respectively main engineering contribution work solution application first order godunov scheme analyze transient hydraulics actual oil well drilling also analysis interpretation pressure wave behavior traveling along well godunov scheme high potential engineering applications modeling transient drilling hydraulics controlled flow underbalanced drilling foam cementing well
transparent concrete cement based building material optical properties due embedded light transmitting elements within composite study design transparent concrete mechanical properties light transmission properties optical fibers use optic fibers discussed study performed literature review focused light absorption translucent concrete transmission mechanism losses transmission information given strength materials proportions result determined lighting power consumption reduced utilizing sun light source buildings use transparent concrete moreover seen provides architecturally aesthetic structures
trauma exposure smoking occur alarmingly high rate however little understanding mechanisms underlying clinically significant relation present study examined perceived stress explanatory mechanism linking posttraumatic stress symptom severity smoking specific avoidance inflexibility perceived barriers smoking cessation negative affect reduction negative reinforcement expectancies smoking among trauma exposed smokers participants trauma exposed treatment seeking daily cigarette smokers female age results indicated posttraumatic stress symptom severity indirect significant effect dependent variables via perceived stress present results provide empirical support perceived stress may underlying mechanism indirectly explains posttraumatic symptoms relation smoking specific avoidance inflexibility perceived barriers smoking cessation negative affect reduction negative reinforcement expectancies among trauma exposed smokers findings suggest may clinical utility targeting perceived stress among trauma exposed smokers via stress management psychoeducation skills training elsevier ltd rights reserved
trauma childhood psychosocial medical public policy problem serious consequences victims society chronic interpersonal violence children common worldwide developmental traumatology systemic investigation psychiatric psychobiological effects chronic overwhelming stress developing child provides framework principles empirically examining neurobiological effects pediatric trauma article focuses peer reviewed literature neurobiological sequelae childhood trauma children adults histories childhood trauma
trauma survivors particularly torture survivors suffer high rates chronic pain posttraumatic stress disorder ptsd years afterward along alterations function pain system basis longitudinal data ptsd symptomatology tested whether exposure torture ptsd ptsd trajectories accounted chronic pain altered pain perception participants torture survivors age matched healthy control subjects chronic pain characterized pain threshold pain tolerance conditioned pain modulation cpm temporal summation pain measured three ptsd trajectories identified among torture survivors chronic delayed resilient lack cpm intense chronic pain found among chronic delayed groups compared resilient healthy control groups temporal summation pain strongest among chronic group ptsd trajectories mediated relationship torture cpm appears duration severity posttraumatic distress rather exposure trauma crucial factors mediate association trauma chronic pain ptsd resultant distress measurable evaluation seems particularly important management pain among trauma survivors results may generalized instances chronic pain persists traumatic events perspective article presents mediation effect ptsd trajectory pain modulation among trauma survivors suggesting duration severity ptsd distress rather exposure trauma per influence perception modulation pain american pain society
traumatic experiences severe impact autonomous nervous system heart rate variability hrv reliable psychophysiological marker autonomous nervous system functioning reduced vagally mediated hrv found patients post traumatic stress disorder ptsd studies patients borderline personality disorder bpd study compared hrv parameters patients ptsd current bpd bpd remission healthy volunteers min resting state electrocardiogram recording unmedicated female participants took part study ptsd current bpd bpd remission healthy volunteers found significant group differences time domain frequency domain total power low frequency high frequency power hrv parameters root mean square successive differences rmssd lowest patients ptsd followed patients bpd remission patients current bpd highest rmssd found healthy volunteers variance hrv higher patients bpd patients ptsd addition rmssd significantly negatively correlated self reported early life maltreatment assessed childhood trauma questionnaire findings point complex interaction traumatic experiences functioning autonomic nervous system psychopathology alterations hrv might related early life maltreatment associated psychological factors rather diagnostic entities
traveling wave thermoacoustic heat engine special device capable converting external heat acoustic work high reliability high potential efficiency coupling linear alternator developed new kind electricity generator called traveling wave thermoacoustic electrical generator paper prototype traveling wave thermoacoustic electrical generator designed tested preliminary experiments due high clearance seal loss caused pistons alternator electric power thermal electrical efficiency obtained far expectation investigation acoustic impedance coupling relationship engine alternator first revealed means numerical approach according relationship working frequency decreased experiments charging mole fraction argon gas system maximum electric power thermal electrical efficiency maximum thermal electrical efficiency electric power obtained successfully operating conditions mean pressure mpa heating temperature degrees cooling temperature degrees far output electric power efficiency highest values thermoacoustic electrical generator work presents new kind thermal electric power generator believed suitable many applications energy area solar energy industrial waste heat elsevier ltd rights reserved
treatment essential thrombocythaemia directed decreasing risk complications disease including arterial venous thrombosis bleeding episodes established risk factors vascular events patients include advanced age years prior history thrombosis haemorrhage role potential risk factors including cardiovascular risk factors leucocytosis high haematocrit jak analysed multiple studies impact thrombocytosis risk vascular events also investigated many clinicians consider elevated platelet count risk factor thrombosis extreme bleeding utilize criterion start cytoreductive therapy however relationship thrombocytosis vascular events controversial solid evidence support use cytoreductive therapy patients risk factors lacking review discuss current treatment recommendations patients biology underlying vascular events risk factors thereof review evidence management patients extreme thrombocytosis
tubular grafts based nanofibers copolymer epsilon caprolactam hexamethylendiaminadipate obtained electrospinning method strength materials based dry nanofibers mpa elongation break mpa saline respectively pressure value liquid started seeping tube wall kpa absence cytotoxicity proved well adhesion proliferation mesenchymal stem cells surface tubes inner diameter tested vivo rat abdominal aorta layer endothelial cells shown form inner side prosthesis days evidence stenosis dilatation prosthesis months observation endothelial subendothelial layers
tumor necrosis factor alpha tnf alpha proinflammatory cytokine important role pathogenesis several diseases encoding gene located short arm chromosome major histocompatibility complex class iii region tnf alpha gene polymorphisms located promoter region thought affect susceptibility severity different human diseases review summarizes data related association tnf alpha gene receptor polymorphisms development autoimmune diseases among polymorphisms tnf alpha promotor polymorphism associated several times development autoimmune diseases however discrepant results recorded tnf alpha gene polymorphisms little association autoimmune diseases current results molecules controlling tnf alpha expression also presented discrepancy different records could related partly either differences ethnic origin number studied individuals abundance activation molecules interact tnf alpha promotor region elements
tumors pediatric facial skeleton represent major challenge clinical practice lead functional impairment facial deformation long term disfigurement treatment often requires multidisciplinary approach radiologists play pivotal role diagnosis management lesions although rare pediatric tumors arising facial bones comprise wide spectrum benign malignant lesions osteogenic fibrogenic hematopoietic neurogenic epithelial origin common lesions include langerhans cell histiocytosis osteoma rare lesions include inflammatory myofibroblastic desmoid tumors juvenile ossifying fibroma primary intraosseous lymphoma ewing sarcoma metastases facial bones neuroblastoma ewing sarcoma retinoblastoma article provides comprehensive approach evaluation children non odontogenic tumors facial skeleton typical findings discussed emphasis added value multimodality multiparametric imaging computed tomography magnetic resonance imaging mri diffusion weighted imaging dwi positron emission tomography pet pet mri key imaging findings characteristic histologic features benign malignant lesions reviewed respective role modality pretherapeutic assessment post treatment follow pitfalls image interpretation addressed avoid
tunneling field effect transistors tfets gaining attention good scalability low leakage current however suffer low state current severe ambipolar conductivity address issues paper proposed novel junctionless nanowire tfet induced source side tunneling realized hetero gate dielectric hgd tfet approach induces local dip conduction band edge tunneling junction leading abrupt transition states well subthreshold swing low dec low drain voltages proposed structure provides also shown length high gate insulator well dielectric constant significantly affect performance power efficiency device
twenty four scientists met aschauhof altenhof germany discuss associations child growth development nutrition health environment psychology meta analyses body height height variability household inequality historic modern growth studies published since highlighting enormously flexible patterns child adolescent height weight increments throughout history depend genetics prenatal development nutrition health economic circumstances reflect social interactions quality life short stature youth questionnaire presented cross culturally assess health related quality life children changes child body proportions recent history relation height longevity historic dutch samples also measures body height skeletal remains belonged topics meeting bayesian approaches monte carlo simulations offer new statistical tools study human growth
two cases unusual situations discussed one involving feigned suicide detected false comparison surveillance systems one involving monozygotic triplets developed psychosis shared delusions although cases involve presentations never encounter clinicians nevertheless serve highlight fundamental questions nature psychopathology cases also compelling parallels literature film
two experiments examined individuals respond restriction presented within approach versus avoidance frame study working problem solving task participants initially free choose strategy second task told change strategy message change embedded either approach avoidance frame confronted avoidance compared approach frame participants reactance toward request greater turn led impaired performance role reactance response threat freedom explicitly examined study participants evaluated potential change policy affecting program study herein explicitly varying whether restriction present absent whether message embedded approach versus avoidance frame communicated avoidance frame restriction participants showed highest resistance terms reactance message agreement evaluation communicator difference agreement change mediated reactance restriction present overall avoidance goal frames associated resistance change different levels experience reactance performance person perception reactance mediated effect goal frame outcomes restriction present
two experiments examined responses bystanders claimed another person experienced discrimination participants read woman man experienced sexism whose worker male female either expressed sympathy claimed target experienced sexism participants evaluated worker bystander overall participants evaluated bystanders claimed someone else experienced discrimination negatively evaluated bystanders claim discrimination furthermore female bystanders claimed discrimination behalf someone else derogated male bystanders additional analyses indicated female bystanders claimed another person experienced discrimination derogated male bystanders former threatened participants beliefs fairness status differences greater extent later
two experiments explored false recall unstudied critical items chair following presentation semantic associates critical word sit desk phonological associates critical word cheer hair every composition hybrid list semantic phonological associates results replicated additive pattern critical false recall hybrid lists relative pure lists found watson balota roediger clarified form false recall function across varying degrees hybridization experiments showed including one two type associate otherwise pure list led considerable increase false recall within subjects design experiment suggested initial rapid increase false recall continued increase gradually apex balanced hybrid list composition whereas subjects design experiment showed false recall plateaued initial rapid increase overall shape function ziggurat furthermore function roughly symmetrical semantic phonological associates appear make equivalent contributions additive false recall hybrid lists results provide constraints theoretical accounts drm false memories accommodated modified activation monitoring framework elsevier inc rights reserved
two experiments investigated cognitive skills underlie children susceptibility semantic phonological false memories deese roediger mcdermott procedure deese roediger mcdermott experiment performance verbal similarities subtest british ability scales bas elliott smith mcculloch predicted correct false recall semantic lures experiment performance yopp singer test phonemic segmentation yopp predict correct recall inversely predicted false recall phonological lures auditory short term memory negative predictor false recall experiment experiment findings discussed terms formation gist verbatim traces proposed fuzzy trace theory reyna brainerd increasing automaticity associations proposed associative activation theory howe wimmer gagnon plumpton elsevier rights reserved
two hypotheses tested respect germination diplolophium marthozianum endemic plant species copper cobalt outcrops katanga democratic republic congo germination copper endemics limited fungal infection absence pathogen control germination success copper endemic species copper dependent seed lots twenty seeds weighed soaked different disinfection treatments placed germination medium containing four distinct copper concentrations days seed viability measured beginning end experiment cut test final germination percentage seed viability affected copper concentration disinfection treatments marthozianum able germinate substrate without added copper despite pervasive fungal infection however seed mass significant positive effect seed germination suggesting selecting largest seeds may ensure highest germination success situ conservation programs
two imaginary skew rack cutter curves stepped triple circular arc teeth presented paper helical gear pair includes gear pinion surfaces generated using two matched imaginary skew rack cutter surfaces mathematical models helical gear pair stepped triple circular arc teeth developed based theory gearing use models analysis kinematic errors illustrated evaluated computer programming tooth contact analysis tca assembly errors used several kinds ideal assembly errors vertical misalignment angles horizontal misalignment angles manufacturing errors helical angles center distance deviation tca revealed sensitivity horizontal misalignment angles lower manufacturing errors helix angles higher vertical misalignment angles
two nationwide representative studies adolescents adults investigated psychological correlates intention penalize public expressions prejudice form support hate speech prohibition presented participants preselected examples hate speech internet mass media assessed willingness support prohibition public expressions remarks studies found social dominance orientation right wing authoritarianism positively correlated outgroup prejudice differential effects hate speech prohibition social dominance orientation positively related acceptance hate speech whereas right wing authoritarianism positively related hate speech prohibition discussing counterintuitive finding suggest right wing authoritarians particularly vigilant toward norm violations makes punitive toward counternormative expressions prejudice hate speech
two new topologies otra based sinusoidal oscillators presented first topology makes use lossless integrators whereas second topology designed using second order pass section proposed topologies made fully integrated implementing resistors using matched transistors operating linear region facilitates electronic tuning oscillation frequency non ideality analysis circuits also given high frequency applications self compensation used workability proposed oscillators verified pspice simulations using agilent cmos process parameters total harmonic distortion thd designs found quite low
two years study conducted evaluate leaf removal red geotextile reflective mulch affect phenolic composition wines three red wine grape cultivars merlot teran plavac mali vitis vinifera leaf removal reflective mulch made weave aluminum platelets protected transparent film sewn together red polypropylene threads tested separately combined vines merlot teran plavac mali years compared untreated control treatments applied veraison strongest influence phenolic composition experimental wines particularly terms increasing gallic acid catechin malvidin glucoside delphinidin glucoside peonidin glucoside content resulted higher gallic acid malvidin glucoside concentrations treatment least effect phenolic composition wines still affected higher epicatechin gallic acid content total phenols anthocyanins flavan ols contents wines exhibited strong correlation antioxidant activity elsevier rights reserved
two dimensional numerical simulations used study coupled fluid structure electric interaction simple model inverted piezoelectric flag investigate dynamics flow structure interaction configuration well energy harvesting performance particular dynamic response inverted flag well associated flow patterns examined range inertia bending stiffness reynolds numbers categorized distinct vibrational states based symmetry motion well amplitude simulations indicate large amplitude vibrations achieved large range parameters also evidence lock flag flutter intrinsic wake shedding phenomenon initial inclination flag prevailing flow found significantly affect flutter performance inclination angles exceeding degrees state large symmetric flutter identified promising energy harvesting effect piezoelectric material parameters energy harvesting performance flutter state examined detail maximum energy efficiency flags found approximately maximum occurs match time scales flutter intrinsic time scale piezoelectric circuit simulations used examine simple scaling law could used predict energy harvesting performance devices
type diabetes associated subfertility men hypothesised results inhibitory effects chronic hyperglycemia testicular function used ins akita mouse model investigate diabetic mice exhibited progressive testicular dysfunction reduction testis weight weeks age diabetic mice showed significantly reduced seminiferous tubule diameters increased spermatogenic disruption although testes morphology appeared grossly normal unexpectedly serum intra testicular testosterone similar groups ins akita mice displayed elevation testicular inflammatory cytokines activin intratesticular activin downregulated activin regulatory proteins follistatin inhibin unchanged activin signalling measured psmad smad production enhanced diabetic mice results suggest prolonged exposure hyperglycemia ins akita mice leads progressive testicular disruption mediated testicular activin activity rather hormonal dysregulation elsevier rights reserved
type diabetes mellitus tdm autoimmune disease characterized lack insulin irreversible destruction islet beta cells order alleviate symptoms lifelong exogenous insulin administration primary treatment tdm recent years novel promising therapy transplantation mesenchymal stem cells mscs without pancreatic islets achieved great therapeutic effects animal models due multipotency along secretion cytokines angiogenic factors immunomodulatory substances plenty evidence showing mscs delay tdm onset reverse hyperglycemia onset increase insulin production date immunoregulation immunosuppression mscs widely proved exact mechanisms still clear enough therefore review mainly discuss immunologic mechanism mscs moderating immune response tdm
type diabetes global epidemic prevalence incidence type diabetes increasing negative effects diabetes kidneys nerves vessels well established effect diabetes reproductive function less well understood important characterize given increasing numbers young women diabetes review summarize available literature women diabetes experience ovarian aging menarche menopause report women type diabetes appear likely ovarian dysfunction manifested delayed menses menstrual irregularities possibly earlier menopause studies women type diabetes inconsistent suggest increased anovulation earlier menopause differences reproductive aging women type type diabetes raise questions potential differences mechanisms contributing ovarian aging although shared glycemic dysregulation fundamental differences insulin presence processing distinguish two diseases review suggests insulin age diagnosis weight play role ovarian dysfunction long term studies needed evaluate multitude factors may disrupt hypothalamic pituitary ovarian function women diabetes elsevier ireland ltd rights reserved
type diabetes mellitus tdm characterized islet beta cell dysfunction insulin resistance leads inability maintain blood glucose homeostasis circulating micrornas mirnas suggested novel biomarkers tdm prediction disease progression however mirnas roles pathogenesis tdm remain fully elucidated present study serum mirna expression profiles tdm patients chinese cohorts examined total rna extracted serum samples patients tdm five healthy controls used reverse transcription quantitative polymerase chain reaction analysis exiqon pcr system serum plasma mirnas total seven mirnas differentially expressed two groups fold change serum expression levels mir mir mir mir higher patients tdm compared healthy subjects however levels mir mir mir lower hierarchical cluster analysis indicated possible separate patients tdm control individuals similar categories differential mirnas target prediction showed tdm candidate genes potentially modulated seven mirnas kyoto encyclopedia genes genomes pathway analysis revealed pathways enriched genes majority pathways enriched targets induced repressed mirnas among insulin adipocytokine tdm pathways several cancer associated pathways previously associated tdm conclusion present study demonstrated serum mirnas may novel biomarkers tdm provided novel insights pathogenesis tdm
typical studies self handicapping operationalize construct narrowly examining obviously debilitating undesirable behaviors ask whether socially positive behaviors including helping others might serve function appreciated using standard self handicapping paradigm females undertook difficult tracing task allegedly related intelligence received either success feedback tasks partially unsolvable non contingent success unsolvable nsu feedback tasks success feedback solvable tasks noncontingent success solvable nss predicted practice period expecting take longer version task nsu nss participants likely help frustrated confederate completing another task spent time engaging confederate less time practicing implications discussed self handicapping theory psychopathology
tyrosine kinase inhibitor related toxicities reported predictive prognostic factors patients affected metastatic renal cell carcinoma mrcc aim investigate incidence cumulative toxicity prognostic role mrcc patients treated sunitinib pazopanib mrcc patients treated sunitinib pazopanib european institute oncology milan reviewed incidence adverse events cumulative toxicity defined presence one selected adverse event grade prognoses evaluated international mrcc database consortium criteria progression free survival pfs overall survival estimated using kaplan meier method cox analysis total patients included final analysis experience selected toxicities one two three toxicities accordingly patients experienced cumulative toxicity without cumulative toxicity median pfs versus months median versus months respectively cumulative toxicity adjusted international mrcc database consortium prognostic groups maintained prognostic role pfs hazard ratio confidence interval hazard ratio confidence interval major limitation retrospective monocentric nature analysis reported prognostic role cumulative toxicity hypertension hypothyroidism hand foot syndrome patients affected mrcc treated sunitinib pazopanib copyright wolters kluwer health inc rights reserved
discourse low income mothers frames social problems presumption deficiency reflected studies parenting logics practices scholars often underestimate sophistication low income mothers parenting logic recognize mothers work hard use appropriately different parenting logics middle class mothers investigate parenting logics african american white low income mothers women demonstrate logic follows many premises middle class parenting strategies additionally seeks address obstacles prevent low income youth reaching goals addiction drug dealing pregnancy street logic leads strategies may appear inexpensive adaptations middle class practices however analysis mothers narratives reveals derivative intended prepare children avoid perils social context study illuminates previously misunderstood version intensive mothering
ubiquitin ligases nedd family important axon dendrite development little known adaptor nedd family interacting protein ndfip responsible enzymatic activation study function ndfip cortical development generated conditional knock conditional neurons ndfip conditional mice viable however cortical neurons adult brain exhibited atrophic characteristics including stunted dendritic arbors blebbing dendrites fewer dendritic spines electron micrographs neurons appeared shrunken compacted somata involutions nuclear membrane culture ndfip neurons exhibited exuberant sprouting suggesting loss developmental control biochemical analysis postsynaptic density psd fractions ndfip cortical hippocampal neurons showed postsynaptic proteins arc psd reduced compared wild type controls addition kinase akt signaling pathway altered results indicate ndfip nedd effectors important development dendrites dendritic spines cortex
udp based dns packet perfect tool hackers launch well known type distributed denial service ddos purpose attack saturate dns server availability resources type attack usually utilizes large number botnet perform spoofing address targeted victim therefore hard dns provider differentiate legitimate attack dns query packets take different approach spoofing detection strategy protect dns server utilizing software defined networking sdn paper present cauth novel mechanism autonomously block spoofing query identified impact legitimate queries manipulating openflow control message whenever server controller receives query packet send authentication packet back client network later client controller also responds via authentication packet back server controller server controller forward query dns server receives replied authentication packet client evaluation cauth instantly manage block spoofing query packet authenticate legitimate query soon mechanism started notably mechanism designed changes existing dns application openflow protocol
ulipristal acetate upa licensed emergency contraceptive europe end may million courses used rationale using upa favor much commonly used levonorgestrel lng based data efficacy safety side effects efficacy two large clinical trials among women presenting hours unprotected sex upa effective lng preventing pregnancy two trials combined meta analysis upa superior almost halving risk pregnancy compared lng biomedical studies shown upa inhibits delays ovulation effectively lng stage cycle risk pregnancy highest safety side effects upa lng similar side effect profiles date serious adverse events attributed use upa data pregnancies conceived association upa use reassuring evidence teratogenesis increased risk ectopic pregnancy miscarriage availability use upa remain limited available without doctor prescription
ultraprecision engineering nanotechnology considered nowadays technologies future products find wide applications various technological fields replacing traditional manufacturing processing industry new applications devices currently investigation scientists engineers promise bring revolution field applied field computer science new quantum computers designed automotive aerospace industry demand systems chip miniaturization allows electronics systems like computer memory guidance navigation communication power sensors actuators fit tiny tip potential high temperature superconductivity high high superconductors promise efficient powerful devices increasing energy efficiency amount electricity flow bringing therefore greater industrial competitiveness improving public quality life new ceramic materials manufactured advanced processing techniques possess profound advantages compared conventional conductors carry much higher currents create larger magnetic fields carry electric current energy loss resistance paper reported activities laboratory manufacturing technology ntua manufacturing engineering focusing onto recent trends developments advanced manufacturing advanced materials mainly emphasizing long standing greek ukrainian russian hungarian scientific cooperation also international involvement worldwide principal research important engineering topics nowadays industrial research academic point view mentioned ultraprecision engineering nanotechnology net shape manufacturing high temperature ceramic superconductors
uml become facto standard design development object oriented systems hand uml includes various diagrams notations missing formal semantics exist much work transform completely uml models executable codes computer aided software engineering tools hidden semantics uml diagrams moreover uml models used automated analysis validation verification systems therefore integration uml semantics based techniques formal methods required overcome type issues proof correctness software models plays key role ensure quality final system developed paper presents systematic method transformation verification uml sequence diagrams specification method works translating analysing important combined fragments sequence diagrams using notation first formal specification primary constructs provided capturing hidden semantics diagram formal analysis interaction operators namely options alternatives loops break fragments provided combined fragments important allows multiple scenarios increase expressive power sequence diagram various control flows finally formal analysis provided eves tool check syntax type proof consistency correctness specification
uncontrolled anthropogenic activities technological revolution increase fossil fuel consumption higher rate prompted researchers looking alternative energy source cover current need future demand energy biomass terrestrial crops studied promising source renewable energy last decades however large scale production still questionable lower productivity indirect use fossil fuel lack land availability food fuel conflict limitations land based system fetch opportunity look untapped potential use microalgae high biomass productivity saline waste water stream unconventional way feedstock generation additionally produce value added products apart clean energy review presents current scenario microalgae applications biofuel production micro algae based high value bio product industries leveraging environmental protection waste utilization benefits microalgae cultivation harvesting biomass conversion technologies biodiesel production reviewed based adapting ancient learning understand critical factors affecting overall productivity economic viability dedicated efforts technical experts still required economic viability large scale biodiesel production spite positive finding small scale several high value bio products microalgae amplified magnetism trades investment field microalgae cultivation intersects two key concern areas global warming water pollution control water recycling sequestration waste water utilization respectively integration suitable upstream downstream processing technologies multiple product portfolio would make microalgae bio refinery economical viable
ambient intelligence auspice many researchers studied area context recognition location users identity activities parameters related users situation environment one aspect context pertained users situation body posture sitting person aim paper design development novel aware chair system recognizes sitting body postures aware chair based digital sensors mounted sitting back area chair chair tested using people different gender body mass height design details system well test results presented paper
investigation article dimensional generalised variable coefficient shallow water wave equation describes interaction riemann wave propagating along axis long wave propagating along axis fluid scaled space coordinates bilinear forms backlund transformation lax pair infinitely many conservation law derived based binary bell polynomials multi soliton solutions constructed via hirota method propagation interaction solitons illustrated graphically variable coefficients affect shape multi soliton interaction scaled space time coordinates positions solitons depend sign wave numbers interaction iii interaction solitons elastic amplitude velocity shape soliton remain invariant interaction except phase shift
investigation paper dimensional dimensional ito equations help bell polynomials method hirota bilinear method symbolic computation bilinear representations soliton solutions bilinear backlund transformations lax pairs two equations obtained respectively particular obtain new bilinear form soliton solutions dimensional ito equation bilinear backlund transformation lax pair dimensional ito equation also obtained first time copyright john wiley sons ltd
investigation paper kadomtsev petviashvili schrodinger system describes long waves shallow water integrability study made painlev test via hirota method bilinear form soliton solutions obtained auxiliary variable collision two solitons found elastic means asymptotic analysis graphical descriptions two three soliton solutions found bright dark solitons collide one another without change physical quantities except small phase shifts process collision
investigation paper inhomogeneous nonlinear schrodinger equation describes propagation large wavelength small amplitude electron plasma wave parabolic distributed constant interactional damping inhomogeneous plasma via hirota method bell polynomial approach symbolic computation bilinear form backlund transformation soliton solutions obtained influence linear density coefficient damping coefficient beta soliton envelopes also discussed affect soliton position beta related soliton intensity velocity phase shift periodically attractive repulsive interactions shown asymptotic analysis shows interactions among solitons elastic
investigation paper inhomogeneous nonlinear schrodinger maxwell bloch system variable dispersion nonlinearity tapered functions describes propagation optical pulses inhomogeneous erbium doped tapered fiber certain coefficient constraints multi soliton solutions obtained darboux transformation method symbolic computation order study impact tapering soliton dynamics inhomogeneous erbium doped periodic distributed amplification system specific form tapered profile considered
investigation paper dimensional coupled nonlinear schrodinger system optical fiber birefringence hirota method bilinear forms system derived via auxiliary function bright one two soliton solutions constructed based soliton solutions soliton propagation interaction investigated analytically graphically non singular cases bright one soliton solutions presented single peak two peak solitons arise respectively analysis bright two soliton solutions elastic inelastic interactions investigated three kinds elastic interactions presented two one peak solitons one peak soliton two peak soliton two two peak solitons
background pubic entrepreneurship people innovation order speed implementation innovation driven development strategy imperative deepen innovation colleges universities entrepreneurship education reform one system multivariate training mode reform comprehensive ability students machine design manufacture automation professional promoted school innovation system campus culture innovation reform strengthened long run effectively improve quality graduates graduate employment competitiveness colleges universities aiming problems process implementing author puts forward countermeasures suggestions
increasing influence trait perspectives leadership current study introduces personality based measure charisma order obtain five factor model ffm prototype charismatic leader experts field leadership personality research invited participate expert panel neo facets experts rated prototypic case successful charismatic leader scale ranging extremely low extremely high based ffm count technique miller bagby pilkonis reynolds lynam easy use count developed facets rated prototypically high low summed together calculate ffm charisma score investigate predictive validity ffm charisma count terms work related outcomes ghent alumni sample used college alumni administered neo entering labor market years later professional careers unfolded results demonstrate ffm charisma positively related extrinsic career outcomes years later including income number subordinates managerial level moreover ffm charisma positively associated adaptive performance career roles directly relate charismatic leadership concluded ffm charisma compound provides opportunities map charismatic tendencies career relevant way elsevier inc rights reserved
understanding barriers seeking care pelvic floor disorders necessary sought assess familiarity pelvic floor disorders well identify screening referral patterns among primary care providers institutional review board approved study distributed secure online server surveymonkeya primary care providers within large healthcare system invited participate question survey regarding prevalence diagnosis treatment urinary incontinence overactive bladder oab syndrome pelvic organ prolapse pop demographic information collected descriptive statistics associations calculated total emails delivered responded response rate respondents evenly distributed respect age years practice providers correctly estimated prevalence oab reported treating conditions respectively treatment failed however referral often urology majority reported screening pop believed prevalence rare referrals pop often urogynecology male providers less likely screen pop female providers minority described familiar urogynecology unaware providers within system primary care providers within large healthcare system familiar oab pop often underestimating prevalence pop nearly one fifth unaware urogynecologists within system educational outreach regarding pelvic floor disorders urogynecology specialty would likely improve patient access care
understanding emotional human behavior multimodal continuous aspect necessary studying human machine interaction creating constituent social agents first step propose system continuous emotional behavior recognition expressed people communication based gesture whole body dynamical motion features used classify motion inspired laban movement analysis entities mapped onto well known russell circumplex model choose specific case study corresponds ideal case multimodal behavior emphasizes body motion expression theater performance using trained neural network annotated data system able describe motion behavior trajectories russell circumplex model diagram theater performances time work contributes understanding human behavior expression first step complete continuous emotion recognition system whose next step adding facial expressions copyright john wiley sons ltd
understanding microaggressions aid learners exploring complexity contemporary racism concept microaggressions refers subtle acts discrimination stemming various individual societal factors combine perpetuate often unintentional unconscious acts racism although much known microaggressions educational tools subject described literature particularly within field social work developed workshop used social work students professionals recognize interrupt microaggressions workshop content includes biopsychosocial framework understanding subtle racism
understanding images via features like edges plays vital role many image processing applications however obtaining optimum edge detector performs well every possible imaging condition still open challenge researchers paper quantitative analysis significant state art edge detection techniques canny prewitt sobel laplacian gaussian fuzzy based edge detection wavelet based edge detector hybrid edge detection technique proposed based correspondence outcomes hybrid edge detection method utilizes fuzzy logic partitioning along wavelet transformation maintain proper balance false detections false positives false negatives rates provides better tracking edge information various subjective well objective quality measures provided quantitative analysis edge detectors experimental results confirm compared techniques hybrid edge detection technique outperform terms edge detection accuracy exclusively images corrupted noises
understanding temporal spatial dimensions land cover dynamics critical factor link ecosystem transformation land environmental management trajectory land cover change simple difference two conditions continuous process therefore need integrate multiple time periods identify slow rapid transformations time mapped land cover composition configuration changes using time series landsat etm images southern chile understand transformation process temperate rainforest relict biodiversity hotspot analysis builds landsat scenes classified using random forests approach base high temporal data set quantify land cover change fragmentation indices fully understand landscape transformation area results show high deforestation process old growth forest strongest beginning study period followed progressive slowdown within different study periods deforestation rates much larger average rate complete study period highest annual deforestation rate deforestation resulted low connectivity native forest patches old growth forest less fragmented concentrated mainly two large regions andes coastal mountain range almost connection secondary forest located intensively used areas highly fragmented exotic forest plantation areas one important economic activities area increased sevenfold especially first periods expense shrubland secondary forest grassland arable land old grown forest analysis underlines importance expanding temporal resolution land cover use change studies guide sustainable ecosystem management strategies increase landscape connectivity integrate landscape planning economic activities study highlighting key role remote sensing sustainable management human influenced ecosystems elsevier ltd rights reserved
understanding activities human videos demanding task computer vision identifying actions accomplished human video sequence automatically tagging actions prime functionality intelligent video systems goal activity recognition identify actions objectives one objects series examination action object environmental condition major applications human activity recognition varies content based video analytics robotics human computer interaction human fall detection ambient intelligence visual surveillance video indexing etc paper collectively summarizes deciphers various methodologies challenges issues human activity recognition systems variants human activity recognition systems human object interactions human human interactions also explored various benchmarking datasets properties explored experimental evaluation various papers analyzed efficiently various performance metrics like precision recall accuracy
understanding contribution resource make power system could indicate value lies paper estimates capacity value load shifting resource capable providing multiple services capacity value represents contribution resource generation adequacy understanding contribution important compare different power system resources assist power system operators planners additionally policy makers market operators need appreciation capacity value different resources order design capacity remuneration mechanisms building energy model coupled power system model optimizing supplyside demand side employed paper estimate capacity value specific load shifting resource resource examined electric thermal storage heating devices space water heating ireland used test case found load shifting devices provide adequacy contribution power system thus capacity value capacity value irish case resource question given year values typically much lower due operational constraints reserve provision due occupancy profile impacts results highlight need holistic modeling demand response resources well need additional work different load shifting resources data elsevier ltd rights reserved
understanding energy demand cities challenge especially countries brazil lack building energy consumption benchmarks makes hard decide upon interventions building stock neither existing attainable energy performance known aiming overcome difficulties study develops framework estimate energy use intensity eui baseline existing building stock category based investigation land use regulations land tax database field surveys offer starting point estimate current energy consumption promising interventions without study specific buildings depth case study high rise commercial building stock took place city belo horizonte brazil three representative typologies identified archetype energy models created order assess eui analysis eui baselines highlights differences archetypes explaining impact technical choices overall electricity consumption indicating growing tendency energy consumption forthcoming buildings archetype analysis also provides knowledge identify promising energy savings potential thus support energy policies city elsevier rights reserved
understanding significance efficiency improvement electric vehicle drivetrain system prospects multi phase electric motors paper discuses research findings elicited comparative performance analysis performed commercially available vehicle conventional three phase permanent magnet motor modified dual stator winding permanent magnet motor derived conventional three phase machine various electrical losses machines estimated compared developed mathematical approach using analytical equations study performed exclusive estimate electrical losses multi phase permanent magnet machine provide decision points various structural design indices machine venturing fea based machine design assessment
underwater gliders used deep water gliding observe large areas minimal energy consumption pitch angle underwater glider important control parameter study involved designing fuzzy pid controller pitch angle underwater glider based hydrodynamics analysis formula pitch angle obtained system identification method used identify transfer function based time domain equation initial experimental data fuzzy pid control algorithm used design controller lake sea trials indicated minimum overshoot reached settling time change angle degrees minimum steady state error degrees advantages could reduce consumption energy improve accuracy gliding trajectory therefore control algorithm applied control pitch gliders rights reserved
unfavorable patient survival coincides lineage plasticity observed human acute leukemias cases assumed arise hematopoietic stem cells stable multipotent differentiation potential however report plasticity leukemia result instable lineage identity states inherited differentiating progenitor cells using mice enhanced myc expression show single cell level lymphoid progenitors retain broad malignant lineage potential high capacity differentiate myeloid leukemia cell derived myeloid blasts retain expression defined set cell transcription factors creating lymphoid epigenetic memory confers growth propagates myeloid lymphoid plasticity based characteristics identified correlating human leukemia cohort revealed targeting jak stat signaling therapeutic possibility collectively study suggests thymus source myeloid leukemia proposes leukemic plasticity driving mechanism moreover results reveal pathway directed therapy option thymus derived myeloid leukemogenesis propose model dynamic progenitor differentiation states shape unique neoplastic identities therapy responses
uniform cooling cylinders internal combustion engine continual challenge many engineers researchers different flow rate velocity coolant similar locations cylinders may cause regions overcooled whereas undercooled study uniform cooling engine desired first governing equations flow solved obtain velocity pressure temperature various points existing engine numerically particle image velocimetry piv method transparent cylinder head made plexiglas used validate numerical simulations validation order reach intelligent cooling strategies small modifications engine coolant inlet outlet along flow rates applied resulted uniform cooling turn prevents cooling
unlike conventional taught learning video games successful keeping players constantly motivated engaged set tasks many hours without apparent loss focus additionally playing gamers solve complex problems without experiencing fatigue frustration would normally accompany comparable learning task methods able deliver deep learner engagement naturally interest academic community thus resulting increasing interest adopting gamification integration gaming elements mechanics frameworks non game situations scenarios means drive student engagement improve information retention however application education challenging task attempts generally restricted one dimensional approach transposing trivial reward system onto existing teaching material empirical evidence presented paper suggests gamified multi dimensional problem based learning approach may yield improved outcomes even applied complex traditionally dry task like teaching computer programming quasi experimental study employed real time sequence scored quizzes instructor feedback live coding deliver fully interactive learning experience using combination classroom version game show wants millionaire kahoot classroom response system crs codecademy online interactive platform python programming course students allowed experience multiple interlocking methods similar would found top quality game experience empirical data learning outcomes gamified group compared control group followed traditional learning path used previous cohorts whilst relatively small study results quite interesting number key metrics including attendance downloading course material final grades
unmanned aerial vehicles become widely used entertainment security building inspection similar tasks inertial navigations systems ins one main area research uavs control flights buildings near constructions flight paths must controlled recorded paper collected approaches used uav onboard trajectory determination gps used determined approach includes onboard inertial measurement unit system image sensors fusing uavs controlling methods computer vision gives possibility increase inertial navigation system accuracy determine distance obstacles dual vision cameras must used authors published elsevier
unplanned unintended pregnancy remains significant challenge adolescents many teens plan ahead opt choose long acting reversible contraceptive methods high failure rates condom usage oral contraceptives less long acting methods emergency contraception remains necessity adolescents seeking second chance prevent unintended consequences unplanned sexual activity present postcoital methods remain available globally intrauterine devices ulipristal acetate selective progesterone modulator mifepristone levonorgestrel ethinyl estradiol plus levonorgestrel norgestrel rarely used progestin methods readily available
unresolved questions remain concerning derivation vagina respect relative contributions mullerian ducts urogenital sinus wolffian ducts recent molecular cellular studies rodents opened large gap level understanding vaginal development mice understanding human vaginal development based histology compare findings mice human vaginal development address gap analysed molecular characteristics urogenital sinus wolffian ducts mullerian ducts week old human specimens using immunohistochemical methods monoclonal antibodies used directed cytokeratin vimentin laminin cadherin caspase hox bmp immunohistochemical analysis revealed weeks epithelium mullerian ducts became positive positive cells originated sinus epithelium reached caudal tip fused mullerian ducts via wolffian ducts lumen fused mullerian ducts closed epithelial plug contained vimentin positive vimentin negative cells subsequently resulting epithelial tube enlarged proliferation basal positive cells first signs squamous differentiation detected week appearance positive cells according results three components namely urogenital sinus wolffian ducts mullerian ducts interacted formation human vagina sinus epithelium provided positive cells wollfian ducts acted transporter mullerian ducts contributed guiding structure vaginal anlagen epithelial differentiation began end period studied extended caudo cranial direction present study one first provide date molecular correlates human vaginal development compared results cell biological studies rodents
hiding methods network steganography described arbitrary ways making difficult compare instance publications describe classical channel characteristics robustness bandwidth others describe embedding hidden information introduce first unified description hiding methods network steganography description method based comprehensive analysis existing publications domain description method applied research community future publications easier categorize compare extend method also serve basis evaluate novelty hiding methods proposed future
urban free roaming dog populations developing world managed patchwork local veterinary practitioners government programs non governmental organizations varied effectiveness lethal removal still commonly practiced vaccination fertility control methods increasingly adopted identifying method provides cost effective management needed inform dog population managers seek limit conflicts like dog bites spread disease predation wildlife describe agent based model simulates population free roaming dogs jaipur northwestern indian city apply various lethal fertility control methodologies identify effectively lowered dog population size spatially explicit model includes temporal demographic details street dog populations modeled data study city tested pairing control type lethal fertility search method target efforts see efficacy altering city dog population size age structure sterilization coverage well number dogs handled models run years assess long term effects intervention found fertility control method targets areas city highest percentage intact bitches outperforms fertility control lethal removal programs reducing population size sterilizing significantly higher proportion population lethal program methods skewed population demographics towards significantly younger dogs thus likely increasing frequency conflict humans work demonstrates benefits modeling differing management policies free roaming dogs elsevier rights reserved
urban green reform existing residential buildings important way achieve totals control energy consumption reduction target carbon dioxide emissions per unit gdp target green building construction paper study existing residential buildings cold region cities towns research building basic information household behavior indoor thermal environment family composition get basic conditions living buildings cold regions factors affects energy consumption meanwhile paper also uses way simulates annual energy consumption existing residential buildings get factors existing residential building affects energy consumption cold regions provide green transformation existing residential building authors published elsevier ltd
urban populations disproportionately experience poor sexual outcomes including high rates teenage pregnancy sexually transmitted infections however contribution substance use across adolescence poor sexual outcomes young adulthood investigated depth despite offering opportunities targeted prevention study aimed estimate joint trajectories adolescent alcohol marijuana use determine relate differently four sexual outcomes multiple sexual partners sex without condom teenage pregnancy contraction sexually transmitted infection young adulthood age data came longitudinal study urban youth followed age age annual assessments adolescence young adulthood sample showed high levels sexual risk young adults average sex without condom past month multiple sexual partners past month one quarter contracted sexually transmitted infection women pregnant teenager men gotten partner pregnant applying longitudinal latent profile analysis estimate joint trajectories alcohol marijuana use grades identified four classes representing high dual use moderate alcohol use moderate alcohol use increasing marijuana use non use class membership differently predicted four outcomes investigated high dual users highest level teenage pregnancy increasing marijuana trajectory highest risk engaging multiple sexual partners past month results suggest implications sexual risk substance use prevention urban youth
urban stormwater major cause urban flooding natural water pollution therefore important assess hydrologic trends urban catchments stormwater management planning study addresses urban hydrological trend analysis examining trends variables characterize hydrological processes original modified mann kendall methods applied trend detection two french catchments chassieu lechere based approximately decade data local monitoring programs catchments trend found major hydrological process driver rainfall variables whereas increasing trends detected runoff flow rates consequence runoff coefficients tend increase study period probably due growing imperviousness local urbanization process addition conceptual urban rainfall runoff model parameters identified via model calibration event based approach examined trend detection results indicate trend time concentration chassieu whereas decreasing trend present lechere however needs validated additional data sensitivity analysis indicates original mann kendall method sensitive noisy values data series
ureaplasma significant cause nongonococcal urethritis case rectal ureaplasma found culture young man sex men previously reported literature nucleic acid amplification tests standard care sexually transmitted infection testing test ureaplasma therefore may missing important infections ureaplasma could important implications urethritis rectal hiv transmission among men sex men engaging condomless anal intercourse study ureaplasma role rectal pathogen may warranted
urinary tract infections utis common bacterial infections women increase incidence menopause important uncover underlying abnormalities modifiable risk factors several risk factors recurrent utis identified including frequency sexual intercourse spermicide use abnormal pelvic anatomy postmenopausal women utis often accompany symptoms signs genitourinary syndrome menopause gsm antimicrobial prophylaxis demonstrated effective reducing risk recurrent utis women may lead drug resistance causative microorganisms indigenous flora increasing prevalence escherichia coli prevalent uropathogen resistant antimicrobial agents stimulated interest novel non antibiotic methods prevention utis evidence shows topical estrogens normalize vaginal flora greatly reduce risk utis use intravaginal estrogens may reasonable postmenopausal women taking oral estrogens number strategies used prevent recurrent utis probiotics cranberry juice mannose studied oral immunostimulants vaginal vaccines bladder instillations hyaluronic acid chondroitin sulfate newer strategies proposed improve urinary symptoms quality life review provides overview utis prophylaxis without antibiotics focusing practical clinical approach women utis elsevier rights reserved
urinary tract infections considered among common infectious disorders humans various infections may role inducing hae attacks study intended evaluate bacteriuria urinalysis patients inh hae urine specimens contributed patients inh hae annual control visits studied retrospectively microorganisms analyzed presence bacteriuria relation clinical symptoms taking account three randomly selected urine specimens found cumulative number edematous attacks higher patients bacteriuria without considering patients attack number significantly higher patients bacteriuria without patients bacteriuria found higher incidence edema formation year evaluation may suggest triggering role bacteriuria occurrence edematous episodes
urtica dioica commonly called stinging nettle herbaceous perennial flowering plant native europe asia northern africa north america best known member nettle genus urtica originally colder regions northern europe asia today herbaceous shrub grows world stinging nettles dioecious herbaceous perennial soft green leaves long strongly serrated margin cordate base acuminate tip stinging nettle available dried leaf tea root tincture rich vitamins iron potassium manganese calcium nettle leaf extract contains active compound reduce tnf alpha inflammatory cytokines stinging nettle long medicinal history stinging nettle used hundreds years treat rheumatism eczema arthritis gout anemia today many people use treat urinary problems early stages enlarged prostate urinary tract infections kidney stones hay fever compresses creams treating joint pain sprains strains tendonitis insect bites
use geotextile reinforcement material improve weak soil popular method days tensile strength geotextile soil geotextile interaction major factors influence improvement soil change fine content within sand change interface behavior soil geotextile present paper bearing capacity unreinforced geotextile reinforced sand different percentages fines studied series model tests carried load settlement curves obtained ultimate load carrying capacity unreinforced reinforced sand different percentages fines compared interface behavior sand geotextile various percentages fines also studied observed sand around fine suitable permissible bearing capacity improvement due application geosynthetic reinforcement effectiveness reinforcement load carrying capacity improvement decreases due addition excessive amount fines
use strontium titanate srtio anode solid oxide fuel cells attracted considerable research attention excellent thermal stability mesoporous srtio increases specific surface area fuel cell reaction turn increases fuel electricity conversion efficiency spray pyrolysis advantageous entails short processing times continuous production study prepared mesoporous srtio particles surfactants pore forming agents may aggregate reduce specific surface area particles stable surfactant concentration range investigated addition short calcination time may cause incomplete decomposition thus generate unreacted phase therefore various calcination temperatures additional wash treatment explored finally srtio powder high specific surface area obtained
users heterogeneous computing systems face two problems first understanding trade relationships observable characteristics applications latency quality result second exploit knowledge characteristics allocate work distributed computing platforms efficiently domain specific approach addresses problems considering subset operations functions models observable characteristics domain metrics may formulated advance populated run time task instances metric models used express allocation work constrained integer program claims illustrated using domain derivatives pricing computational finance domain metrics workload latency pricing accuracy large varied workload black scholes heston model based option pricing tasks running upon diverse array multicore cpus gpus fpgas platforms predictions made models makespan accuracy generally within percent run time performance models used inputs machine learning milp based workload allocation approaches latency improvement times heuristic approach seen
using combination scholarly literature media reports paper classifies instances subtle bias microaggressions toward female athletes united states identify three common microaggression themes athletes based sue taxonomy assumption inferiority objectification restrictive gender roles apply themes explore ways female athletes experience pervasive subtle gender based biases women assumed inferior athletes therefore receive media coverage dismissive abilities receive coverage media also focus primarily appearance female athletes regardless athletic successes quick recoil women fit traditional feminine mold examine microaggressions associated deleterious biological cognitive behavioral consequences among athletes also explore effect microaggressions self image physical fitness female non athletes finally potential avenues future research discussed
using nationally representative data set public religion research institute american values survey conduct multivariate regression analysis determine empirical impact attitudes regarding birth control mandate abortion presidential vote choice also conduct factor analysis determine whether voters conceptualized birth control mandate abortion similarly find support obama administration birth control mandate significantly related voting obama women men voters although impact stronger women however impact war women rhetoric voters choices limited issue insurance coverage birth control rather extending issue abortion unlike attitudes abortion find voters conceptualized birth control mandate less culture war issue role government issue given conceptualization mandate voters findings reaffirm previous research suggests gender gap voting largely driven attitudinal differences regarding role government providing social welfare benefits equal opportunity women
using pattern based approach worry explored relation military youths developmental contextual characteristics pivotal outcomes depressive symptoms self efficacy well coping styles academic performance deployment adjustment data collected parents adolescents age living usa families variations individual characteristics age gender military family factors rank recent deployment parents resilient coping abilities family relational characteristics parents marital status warm parenting marital quality related heterogeneous worry typologies depressive symptoms self efficacy well varied across worry typologies implications drawn findings identifying potential interventions accessed modify worry patterns limit harmful effects
using unique transaction database condominiums tokyo metropolitan area hedonic analytical framework finds eco labelled buildings command small significant premium asking transaction prices finding consistent results countries contrast studies present analysis also incorporates buyer characteristics provide information sources demand eco labelled real estate separate estimation subgroups reveals price premium primarily driven wealthier households exhibit higher willingness pay eco labelled condominiums total amount fraction total sales price less affluent households also shown pay higher prices eco label effect less pronounced results indicate capitalised utility bill savings likely account large proportion observed premium higher premium paid affluent households suggests intangible benefits living green building may also play role elsevier inc rights reserved
using closed loop control internal combustion engine beneficial reducing emission fuel consumption accurate combustion parameters foundation effective closed loop control combustion parameters including start combustion location maximum pressure rise rate location peak pressure identified vibration signals empirical mode decomposition emd method introduced reconstruct vibration acceleration signal combustion parameters identified however angle deviations combustion parameters extracted reconstructed vibration acceleration signal cylinder pressure algorithms correct angle deviations introduced system deviation value used correct extracted start combustion error bound within degrees two algorithms proposed correct deviation predicted location maximum pressure rise rate cylinder pressure test results show two algorithms able correct deviation within degrees error bound location peak pressure predicted knee point following peak value reconstructed vibration acceleration signal predicted result corrected using linear regression location peak pressure versus knee point within degrees error bound real time monitoring framework utilized calculating combustion parameter prediction elsevier ltd rights reserved
using data executive mba students teams business simulation project explored shared leadership team learning behaviors influence time self managed teams stability leadership network structure network churn associated team learning behaviors found shared leadership stimulated team learning behaviors manner consistent previous research early stages teams work together middle later stages task also found teams engaged learning behaviors early task likely keep leadership network structure stable stability positively associated team learning behaviors midpoint end task use findings elaborate theory leadership learning self managed teams develop change influence time
using data fragile families child wellbeing study present study examined two aspects maternal gatekeeping relation low income predominantly nonresidential fathers engagement young children facilitation encouragement results showed maternal encouragement children years old positively longitudinally related higher levels paternal engagement year old children however maternal facilitation age negatively associated later levels paternal engagement moreover coresidential status mothers fathers influence relationship among facilitation encouragement paternal engagement implications future research practice discussed article
using digital elevation models dems viewshed analysis algorithms determine visibility point terrain given location space data parallel algorithm real time viewshed analysis grid dem poses practical challenge personal computer users particularly dealing higher resolution accuracy large terrain data therefore paper presents universal domain decomposition algorithm based equal area strategy parallel viewshed analysis cluster system approach uses scan line filling method data partitioning irregular bounding polygon terrain terrain data divided sectors area connected viewpoint region vertices ignoring null value nodata points furthermore sector assigned one processor organized form triples composed location elevation one point index triples built store locations terminal vertices row row thus random access point achieved using offsets row two commonly applied viewshed algorithms namely reference plane xdraw algorithms employed verify performance addition two experiments focus evaluating efficiency performance comparing traditional implementation respectively experimental results demonstrate significant performance improvement compared sequential computing method memory usage gradually decreases number processors increases based equal area decomposition partitions terms sectors guarantee suitable load balance additional benefits proposed solution also include high storage efficiency program portability
using integrated administrative data criminal justice social service systems harness information meaningful ways transcend traditional silos allow communities focus collective attention important social issues cross systemic boundaries despite recent advances use integrated administrative data practical information promote adoption new users lacking provide introduction potential uses integrated administrative data criminal justice researchers including general benefits using integrated data well implications innovative research design describe case example data integration state data warehouse federally funded project impact incarceration families project utilizes data eight agencies corrections juvenile justice mental health substance use social services health education environmental control includes development online analytical processing cube draw lessons learned provide specific recommendations developing researcher practitioner partnerships use integrated administrative data improve translational criminal justice research evidence based practice policy
using longitudinal data jiangsu fertility intention behaviour study jfibs year study analyses fertility intention behaviour women qualified two children psychosocial point view based theory planned behaviour theoretical framework fertility intention fertility behaviour reconstructed observing phenomenon micro level gap female fertility intention behaviour associated factors studied result shows given situation qualified two children according government birth control policy faced choice whether second child people tend make decisions rationally attitudes towards fertility subjective norms perceived behaviour control contribute significantly discrepancy fertility intention behaviour addition formation concrete birth plan major driving force translating fertility intention action
using non woven polypropylene geotextile filtration unit designed portable prototype filter capable defluoridation desalination filtration unit contains geotextile bag filled mica graphite sand emphasis given make filter design simple possible suitable rural areas designed filter continuously tested three months along ceramic candle filter pureit filter comparative studies performance filters evaluated basis percentage residue removed individual filters cleaning period filters results improvement water quality made prototypes filter without cleaning show reduction concentration fluoride electrical conductivity respectively two filters despite weekly cleaning shows reduction concentration fluoride ceramic filter pureit filter respectively prototype filter simple design performed better filters complex designs test shows uses non woven geotextiles polypropylene along sand provide alternate solution expensive defluoridation desalination processes
using specified telluride glasses prepare glass ceramics containing narrow band gap telluride crystals main precipitated phase would effective route developing high efficiency thermoelectric materials unfortunately telluride glasses extremely difficult achieve paper strategy proposed vitrify narrow band gap tellurides jointly focusing glass formation thermodynamic kinetic factors novel gate snte glasses successfully synthesized glass forming region found located snte rich compositions elsevier rights reserved
using chinese stock market data paper examines sell may away puzzle first identified bouman jacobsen find strong existence sell may effect robust different regression assumptions industries controlling january february effect however part puzzle subsumed seasonal affective disorder effect construct trading strategy based puzzle find outperforms buy hold strategy could resist market downside risk large recession periods elsevier inc rights reserved
using high resolution remote sensing images extracting urban features high resolution remote sensing images complex difficult task improvement geospatial technologies brought forward many solutions help improving process urban feature extraction data collection using light detection ranging lidar capturing high resolution optical images concurrently one solutions research proves fusion high resolution optical image lidar data improve image processing results based increasing urban features extraction success rate reducing oversegmentation fusion process relies first wavelet transform techniques run several times different parameters rules innovative technique implemented improve fusion process two techniques compared reduced fragmented segments created homogeneous urban features however fused image innovative technique improved accuracy segmentation results average accuracy building detection maximum minimum using innovative technique compared fusion wavelet fusion based techniques furthermore index used measure quality building details detected using innovative fusion technique result indicates quality index greater equal
usnic acid atranorin known sunscreen substances natural lichen population cytotoxic substances human cell lines substances isolated acetone extracts cladonia foliacea pseudevernia furfuracea respectively photoprotective activities irradiated human keratinocyte hacat cells destructive effects non irradiated hacat cells compared modified method order assess effects mitochondrial metabolic activity mtt assay membrane integrity ldh assay apoptosis dapi staining cytoskeleton integrity tritc phalloidin staining study showed usnic acid atranorin substantial photosensitizing activity appears linked crystallized forms lichen populations decreased amounts spring summer seasons ultraviolet radiation maximum however cytotoxic apoptotic cytoskeleton deleterious activities may considerable obstacle use human skin care
usually security traditional cryptography works integer numbers chaotic cryptosystem works real numbers worthy study classical chaotic map real domain disadvantage calculation accuracy floating point number doubled map implemented computer serious drawback practical application logistic map classical chaotic system used chaotic cipher real number field inevitably leads degradation finite precision computer environment also difficult guarantee security solve drawbacks extend logistic map finite field paper consider logistic map finite field analyze period property sequences generated logistic map moreover discuss control parameters may influence behavior mapping show logistic map may suitable application performance analysis ultimately find exists automorphic map two logistic maps different control parameters makes suitable sequence generator cryptosystem automorphic sequence generated algorithm based logistic map designed analyzed detail sequences used pseudorandom number generator chaotic stream cipher chaotic block cipher etc
utilisation submerged vanes front intake ports effective approach address sedimentation lateral intakes rivers strategically installed flow training structures could increase mid depth near surface flows intake simultaneously prevent bed load transport entering intake channels effectiveness submerged vanes depends number shape dimensions configuration determination optimum values dimensions configuration vanes challenging effect many parameters effective sedimentation intake zone must investigated study effort made determine appropriate dimensions submerged vanes installed front degrees intake straight channel fuzzy topsis multi objective optimisation method utilised optimisation process considering ten parameters simulations conducted three discharge ratios results show height times flow depth length four times vane height appropriate dimensions utilisation submerged vanes front lateral intakes straight channels
utility sector reform spread across developing world egypt many cases pace nature reform challenged state owned national incumbent however egyptian telecommunications sector rapid growth cellular market overtaken archaic fixed line system hence national monopoly provider telecom egypt stripped market power market diversified implemented public sector reform privatization placed efficiency pressures resulting improved outcomes range stakeholders consumers workers government including reduced prices increased access improved service quality experience offers lessons policy makers researchers liberalization face entrenched state interests however nuances findings relating market type fixed line versus cellular residential versus non residential national versus international despite attempted improvements direct competition retail market led deterioration financial performance although partially offset monopoly supply essential input degree protection provided regulator sympathetic evidence case study supports concept staggered introduction competition however protecting inefficient market insiders firms workers always expense potentially efficient outsiders author published elsevier ltd
utilization cloud technologies recently attained profile building information modeling bim many studies investigated potential role cloud facilitating use bim construction domain addition recent studies focused role cloud facilitating team collaboration across building lifecycle applying bim governance model lack suitable means governance collaboration access archival data cited key barrier widespread adoption collaborative bim environments study therefore investigates requirements bim governance develops specifications cloud based bim governance platform governbim study also uses findings wide consultation combination software engineering approaches using business process model notation bpmn unified modeling language uml define platform requirements specifications platform also aims provide computerized solution overall bim governance solution facilitate team collaboration mange generated bim data project lifecycle ensures data consistent available hosted scalable storage environment high performance computing capabilities results study define functional nonfunctional domain specific requirements developing governbim platform develop set bpmn diagrams describe internal external business procedures governbim platform lifecycle setting configuring managing using governbim platform evaluate several fundamental uml use cases adoption governbim platform present core bim governance model uml class diagram present internal structure governbim platform provide well structured cloud based architecture develop governbim platform practical implementation
utilizing lens interpersonal implications physical interpersonal distances social contexts set variables present professional discourse fade away article explores interactive process displayed protagonic couple bela bartok opera bluebeard castle exercise aimed underlining value maintaining proxemics explicit level observation clinical practice interpersonal research
utilizing qualitative data gleaned focus groups adolescent girls participating cybersecurity summer program mean age study examines following research questions adolescent girls perceive cybersecurity field promising practices engage girls cybersecurity education guided ecological social role theories findings reveal single sex collaborative settings encouraging supportive teachers female mentors practices contribute girls increased interest field cybersecurity findings also suggest emphasis creative collaborative problem solving processes real world application inherent cybersecurity likely increase girls engagement field results implications educators researchers policy makers aiming close gender gaps field computer science build interest cybersecurity area critical national need
vagus nerve stimulation vns reported effective abortive treatment migraine cluster headache using validated animal models acute dural intracranial migraine like trigeminal autonomic cluster like head pain tested whether vns suppresses ongoing nociceptive evoked firing trigeminocervical neurons explain abortive effects migraine cluster headache unilateral vns applied invasively via hook electrodes placed vagus nerve single dose ipsilateral contralateral vns trigeminal recording dural stimulating side suppressed ongoing spontaneous noxious dural evoked trigeminocervical neuronal firing effect dose dependent two doses ipsilateral vns prolonging suppression ongoing spontaneous firing maximally similar three hours dural evoked delta fiber similar fiber similar responses least two hours statistically difference ipsilateral contralateral groups two doses vns also suppressed superior salivatory nucleus evoked trigeminocervical neuronal responses maximally similar model nociceptive activation trigeminal autonomic pathway vns effect normal somatosensory cutaneous facial responses throughout studies provide mechanistic rationale observed benefits vns abortive treatment migraine cluster headache addition validate preclinical models suitable approaches optimize therapeutic efficacy provide opportunity hypothesize dissect neurobiological mechanisms vns treatment primary headaches elsevier inc rights reserved
validation estimated model trivial task depends purpose model usually defines important features model thus validation process use diverse tools exploit different domains recommended aim scale model validation proposed combines normalized root mean square error nrmse two new indices coherence based index fourth order cross cumulant index proposed scale used validation three models logistic map duffing ueda oscillator buck converter results demonstrated proposed model validation scale produces complete validation process takes account time frequency information provides robustness gaussian noise
varenicline smoking cessation aid limited data exist concerning safety human pregnancy multicentre prospective observational comparative cohort study undertaken using surveillance data collected european network teratology information services study sample consisted varenicline exposed pregnancies two matched comparator groups nonteratogen exposed nte controls exposed nicotine replacement therapy bupropion nrt smoking cessation exposed pregnancies varenicline use occurred first trimester considerable proportion discontinuing use early stages pregnancy major congenital malformation rate keeping expected background rate significantly increased first trimester varenicline exposed infants comparison non exposed controls nte nrt however small sample size produced imprecise risk estimates elsevier inc rights reserved
various security devices produce large volume logs alerts used widely troublesome time consuming task network managers analyze deal information paper presented improved alerts aggregation method based grey correlation attribute similarity method used grey correlation ascertain importance alert attributes network security considered weight attributes combined attribute similarity method calculated overall feature similarity order complete alert aggregation experiments results showed method strict mathematical theory basis higher practical value effectively reduce raw alerts reduce redundancy alert data fusion
various studies shown irritable bowel syndrome ibs highly associated pathologies including fibromyalgia objective study analyze differences among risk factors associated ibs following nationwide prospective cohort study propose relationship exists ibs article presents evidence obtained cohort study used data taiwan national health insurance research database clarify relationship ibs follow period ran start diagnosis date ibs event censoring december analyzed risk ibs using cox proportional hazard regression models including sex age comorbidities follow period overall incidence ibs higher patients non patients per person years crude hazard ratio confidence interval adjustment age sex comorbidities associated fold increased risk ibs mutually risk factors may influence relationship ibs recommend physiologists conduct annual examinations patients reduce incidence ibs progression
various versions typical control panels experimentally analyzed effectiveness efficiency point view stimuli differed objects locations within panel type expected response presented stimuli results users performance investigated using classical analyses variance moreover visual activity examined persons gathered means eye tracking system presented formally analyzed
vasodilator stimulated phosphoprotein vasp ena vasp like evl cytoskeletal effector proteins implicated regulating cell morphology adhesion migration various cell types however role proteins cell motility adhesion vivo trafficking remains poorly understood study identifies specific role evl vasp cell diapedesis trafficking demonstrate evl vasp selectively required activated cell trafficking required normal cell development naive cell trafficking lymph nodes spleen using amodel multiple sclerosis show impairment trafficking evl vasp deficient activated cells inflamed central nervous system mice experimental autoimmune encephalomyelitis additionally found defect trafficking evl vasp double knockout dko cells inflamed skin secondary lymphoid organs deletion evl vasp resulted impairment alpha integrin cdd expression function unexpectedly evl vasp dko cells exhibit alterations shear resistant adhesion crawling primary endothelial cells physiologic shear forces instead deletion evl vasp impaired cell diapedesis furthermore cell diapedesis became equivalent control evl vasp dko cells upon alpha integrin blockade overall evl vasp selectively mediate activated cell trafficking promoting diapedesis step transendothelial migration alpha integrin dependent manner
vbf collection classes designed analyzing vector boolean functions functions map boolean vector another boolean vector cryptographic perspective implementation uses ntl library victor shoup adding new modules call ntl functions complement existing ones making better suited cryptography class representing vector boolean function initialized several alternative types data structures truth table trace representation algebraic normal form anf among others relevant cryptographic criteria block stream ciphers well hash functions evaluated vbf obtains nonlinearity linearity distance algebraic degree linear structures frequency distribution absolute values walsh spectrum autocorrelation spectrum among others addition operations equality testing composition inversion sum direct sum bricklayering parallel application vector boolean functions employed rijndael cipher adding coordinate functions two vector boolean functions presented finally three real applications library described first one analyzes kasumi block cipher second one analyzes mini aes cipher third one finds boolean functions high nonlinearity key property robustness linear attacks
vehicle driveability describes complex interactions driver vehicle mainly related longitudinal vibrations today relevant part driveability process optimisation realised means track tests require considerable effort due number parameters stiffness damping components affecting behaviour drawback approach carried stage design iteration becomes expensive terms time cost objective work propose light accurate tool represent relevant quantities involved driveability analysis understand main vehicle parameters influence torsional vibrations transmitted driver particular attention devoted role tyre engine mount dual mass flywheel possible interactions presented nonlinear dynamic model validated time frequency domain linearisation nonlinear components allows exploit modal energy analysis objective indexes regarding driving comfort additionally considered order evaluate possible driveability improvements related sensitivity powertrain parameters
vendor lock major barrier adoption cloud computing due lack standardization current solutions efforts tackling vendor lock problem predominantly technology oriented limited studies exist analyse highlight complexity vendor lock problem cloud environment consequently customers unaware proprietary standards inhibit interoperability portability applications taking services vendors paper provides critical analysis vendor lock problem business perspective survey based qualitative quantitative approaches conducted study identified main risk factors give rise lock situations analysis survey participants shows computing resources migrate premise cloud vendor lock problem exacerbated furthermore findings exemplify importance interoperability portability standards cloud computing number strategies proposed avoid mitigate lock risks migrating cloud computing strategies relate contracts selection vendors support standardised formats protocols regarding standard data structures apis developing awareness commonalities dependencies among cloud based solutions strongly believe implementation strategies great potential reduce risks vendor lock
verbal mimicry research claims repeating words spoken another makes people eager comply requests made mimicker fulfilling request donate charity instead another mechanism might explain results recent studies found request preceded engaging participant dialogue defined short conversation participant willing fulfill request thus verbal mimicry might perceived way dialogue case theoretical confound would revealed test whether mechanisms different two field studies conducted using dialogue yes mimicry yes design study results revealed two main effects interaction effects means verbal mimicry dialogue two distinct mechanisms interestingly additive effects mechanisms found
verizon data breach investigations report states local area network lan access top vector insider threats misuses ethernet common vulnerabilities come address resolution protocol arp critical students learn vulnerabilities understand mechanisms exploits know countermeasures include static arp cache entries improved arp module operating systems encryption intrusion detection data backup paper introduce hands lab help students learn arp spoofing attack works objective lab let students successfully become man middle manually creating attack packets although tools exist carry arp spoofing attack automatically asking students create raw arp spoofing packets help understand mechanisms attack method much deeper automatic tools studied effectiveness lab students understanding lan vulnerabilities tests conducted measure performance students using tool gave students surveys completed hands lab students selected interview independent evaluator result shows tool help students understand concept arp spoofing attacks motivate learning cyber security
high frequency vhf converters conventional driving scheme suffer serious efficiency drop entire input voltage range due gate drive timing mismatch egan control synchronous rectification hemts digital adaptive driving scheme proposed adjust control gate drive signals efficiently input voltage range state space model derived predict drive timing precisely according different input voltage adjust gate drive signals correspondingly high time resolution circuit improve time resolution selecting cascaded high speed buffers proposed proposed driving scheme high frequency switching loss reverse conduction time egan hemts reduced significantly maintain high efficiency entire input voltage range mhz vhf flyback printed circuit board pcb fabrication air core transformer built input output measured efficiency realizes input output proposed solution improves efficiency using conventional driver improvement
via mental simulation future previews shown optimize behavioral selection enhance task performance yet little known critical factors determine exactly imagination impacts behavior noting theoretical importance vantage point field observer perspective mental imagery explored possibility spatial visual perspective influences real time behavioral correlates simulated imagined events participants instructed imagine positive negative social encounters either field observer vantage point throughout imagined interaction postural movement anterioposterior front back plane served real time index approach withdrawal behavior results revealed mental simulations accompanied functionally adaptive behavior approach withdrawal events imagined field perspective theoretical practical implications findings considered
victims trauma often remember experience traumatic later compared immediately event took place finding memory amplification effect associated increased experiencing symptoms however effect found almost exclusively field based studies examined whether effect could replicated laboratory two studies exposed participants negative photographs assessed memory photographs analogue ptsd symptoms two occasions study analogue symptoms follow positively associated remembering negative photos overtime study focused memory amplifiers people whose memory photos amplified time consistent field research analogue experiencing symptoms associated memory amplification overall findings confirm analogue ptsd symptoms also associated amplified memory trauma analogue elsevier ltd rights reserved
video game play negative effect affect behavior relationship cognition mixed previous research shown positive negative effects video game play attention memory cognitive abilities however little research investigated effects executive functions working memory additionally studies utilized predominantly male samples present study sought examine effects active video game play decision making problem solving risk taking two hundred twenty eight undergraduate students female played one five different video games part separate game control condition scores iowa gambling task igt balloon analogue risk task bart wisconsin card sorting task wcst compared following active video game play participants decided advantageously igt made fewer errors completed categories wcst group differences emerged bart gender impact dependent variables appears active video game play may positive effects executive functions implications real world behavior implications future research discussed elsevier ltd rights reserved
video surveillance biomedical research received great attention active application oriented research areas computer vision artificial intelligence image processing visual analysis human motion presently one active research areas video surveillance system human motion analysis relates detection tracking recognition activities people generally understanding human behaviours image sequences involving humans road side traffic video surveillance aims using several image processing methods obtain better traffic road safety turn provides direct solution reducing death rate accident victims distributed computing process efficient solution scalability issues traffic video surveillance system paper road traffic video surveillance system proposed automatically identify road accidents live video files system alerts neighbouring hospitals highway rescue teams accidents occur paper proposes methodology process video file using map reduce framework better network service better scalability solution surveillance system distributed video files enhanced gaussian filtering efficient object classification detection carried using linear discriminant analysis lda support vector machine svm traffic monitoring using video files surveillance camera foreground object segmentation vital task carried markov random field mrf bayesian estimation process proposed method efficiently track classify foreground objects use object classification detection improve traffic monitoring traffic scenes results obtained experiments proposed research shows efficiency traffic monitoring using traffic scenes
vinyl laurate used manufacture polyvinyl acetate vinyl laurate copolymer component gum base chewing gum production potential toxicity reproduction examined combined repeated dose reproduction developmental toxicity screening study oecd test guideline prenatal developmental toxicity screening study oecd test guideline administered wistar rats gavage controls signs systemic toxicity parental animals either study adverse effects reproductive performance fetal development could attributed treatment observed thus highest dose level tested noael two studies elsevier inc rights reserved
violence serious public health issue across world article assists clinicians understanding date literature regarding structural functional brain theories related risk violence article review anatomic regions brain implicated violence associated personality constructs associated violence discuss different imaging techniques used uncover abnormal brain volume associations functions throughout brain samples violence history risk finally discuss implications findings treatment considerations future research directions
viral infection starts virus particle landing cell surface followed penetration plasma membrane due difficulty measuring rapid motion small sized virus particles membrane little known virus particle reaches endocytic site landing random location use coherent brightfield cobri microscopy investigate early stage viral infection ultrahigh spatiotemporal resolution detecting intrinsic scattered light via imaging based interferometry cobri microscopy allows track motion single vaccinia virus particle nanometer spatial precision microsecond temporal resolution frames per second explore possibility differentiating virus signal cell background based distinct spatial temporal behaviors via digital image processing image postprocessing relatively stationary background scattering cellular structures effectively removed generating background free image diffusive virus particle precise localization using method unveil single virus particles exploring cell plasma membranes attachment found immediately attaching membrane within second virus particle locally confined within hundreds nanometers virus particle diffuses laterally high diffusion coefficient similar microsecond time scales ultrahigh speed scattering based optical imaging may provide opportunities resolving rapid virus receptor interactions nanometer clarity
viral liver diseases frequent comorbidities major contributors death hiv positive individuals antiretroviral therapy although cure hepatitis control hepatitis antivirals avert liver disease progression hiv coinfected patients lack satisfactory treatment hepatitis delta virus hdv infection remains major threat developing cirrhosis liver cancer population european union north america sexual contact replaced injection drug use major transmission route hdv hiv positive persons pegifn approved hdv therapy however sustained hdv rna clearance achieved less recent discovery sodium taurocholate cotransporting polypeptide key hepatitis virus hbv hdv cell entry receptor opened door new therapeutic era indeed promising results released using myrcludex sodium taurocholate cotransporting polypeptide inhibitor encouraging data new classes hdv blockers prenylation inhibitors lonafarnib nucleic acid polymers time sustained suppression hdv replication primary goal hdv therapy associated normalization liver enzymes histological improvement note use specific antivirals hdv must given along anti hbv agents prevent hbv rebounds following removal viral interference lack persistent forms hdv rna could provide unique opportunity curing hepatitis delta even without eliminating hbv circular covalently closed dna ultimately suppression hdv replication along hepatitis surface antigen clearance drugs would best reflect hepatitis delta cure copyright wolters kluwer health inc rights reserved
virtual reality increasingly used persuasive technology attitude behavior change paper considers terror management theory tmt one notable theories considered far persuasive technology aims exploring use experiences first show experience used effectively elicit mortality salience makes tmt applicable evaluate effects experience attitudes towards risk wearing head mounted display hmd participants explored one two virtual environments ves first group participants represented cemetery cues like tombs burial recesses second group participants cues removed looked like public park results show cues manipulation changed effects experience users attitudes towards risk tmt would predict moreover results revealed relationship elicited physiological correlates arousal finally show user personality traits moderate effects experience attitudes towards risk
virtual reality reaching consumer space mobile virtual reality solutions nowadays widely available affordable many smartphones adding case attached lenses around phone create head mounted display using public places social gatherings head mounted display given around others lead problems regarding social acceptance surrounding people aware virtual reality user seeing address problem adding second front facing screen head mounted display build evaluate two prototypes usage
virtual screening search bioactive compounds via computational methods provides wide range opportunities speed drug development reduce associated risks costs virtual screening already standard practice pharmaceutical companies applications preclinical academic research still remain exploited spite increasing availability dedicated free databases software tools survey overview recent developments field presented focusing free software data repositories screening alternatives commercial counterparts outlining available resources interlinked comprehensive virtual screening pipeline using typical academic computing facilities finally facilitate set corresponding pipelines downloadable software system provided using platform virtualization integrate pre installed screening tools scripts reproducible application across different operating systems
virtue based approaches engineering ethics recently received considerable attention within field engineering education proponents virtue ethics engineering argue approach practically pedagogically superior traditional approaches engineering ethics including study professional codes ethics normative theories behavior paper argues virtue based approach interpreted current literature neither practically pedagogically effective significant subpopulation within engineering engineers high functioning autism spectrum disorder asd main argument adopting character based approach could successfully applied engineering traditional rule based algorithmic ethical approaches oversight problematic proponents virtue based view furthermore without addressing concerns wide adoption virtue based approach engineering ethics potential isolate individuals asd devalue contributions moral practice end paper gestures towards way incorporating important insights virtue ethics engineering would inclusive asd
visual techniques qualitative assessment roads rank roads either good widely used international confederation transport although quantitative techniques iri international index roughness use techniques involves higher cost technique compared visual one due fact need special quite expensive equipment work developed new quantitative indicator roads able evaluate compare terms surface quality without relying visual analysis low cost acquisition system based analog axis accelerometer microcontroller developed also developed algorithm able evaluate rank road scale ranging two roads visually rated good bad used references tested different types roads without holes tests conducted vehicle running results showed greater amount holes unevenness worst quality indicator depends speed vehicle concluded quantitative analysis road might automatically done using low cost measuring system
visual tracking challenging computer vision task due significant observation changes target contrast tracking task relatively easy humans article propose tracker inspired cognitive psychological memory mechanism decomposes tracking task sensory memory register short term memory tracker long term memory tracker like humans sensory memory register captures information three dimensional perception short term memory tracker builds highly plastic observation model via memory rehearsal long term memory tracker builds highly stable observation model via memory encoding retrieval cooperative models tracker easily handle various tracking scenarios addition appearance shape learning method proposed update two dimensional appearance model three dimensional shape model appropriately extensive experimental results large scale benchmark data set demonstrate proposed method outperforms state art two dimensional three dimensional trackers terms efficiency accuracy robustness
visualising interactions across urban water systems explore transition change processes requires development methods models different scales paper contributes model representing network interactions rainwater harvesting rwh infrastructure innovators organisations rwh niche identify resilience sustainability feature within niche governance practice rwh network interaction model constructed using modified participatory social network analysis sna sna analysed application two part analytical framework based niche management safe resilient sustainable safe sure framework weak interactions rwh infrastructure innovators organisations highlighted reliance limited number persuaders influence regime landscape underrepresented features niche creation management exhibited rwh network interaction model though observed characteristics represented additional safe sure features identified covering diverse innovation responsivity protection unconverged expectations primary influencers polycentric adaptive governance multiple learning types features enable rwh infrastructure innovators organisations reflect improving resilience sustainability though research sectors would useful verify validate observation seven features
visualization workflows important services expert users analyze watersheds using hydroterre end end workflows analysis interactive iterative process demonstrate expert user focus model results data preparation using web application rapidly create tune calibrate hydrological models anywhere continental usa conus hydroterre system captures user interaction provenance reproducibility share modeling strategies modelers end end workflow consists four workflows first data workflows using essential terrestrial variables etv data sets demonstrated construct watershed models anywhere conus leonard duffy second data model workflows transform data workflow results model inputs model inputs consumed third workflow model workflows leonard duffy handle distribution data model within high performance computing hpc environments article focuses fourth workflow visualization workflows consume first three workflows form end end system create share hydrological model results efficiently analysis peer review show visualization workflows incorporated hydroterre infrastructure design demonstrate efficiency robustness expert modeler produce analyze share new hydrological models using conus national datasets elsevier ltd rights reserved
vitamin deficiency linked schizophrenia aimed determine whether patients first episode psychosis fep lower vitamin levels compared controls considering final diagnosis conducted cross sectional study determining hydroxyvitamin blood levels hydroxyvitamin levels considered optimum greater group adult patients fep group healthy controls matched age recruited patient group subdivided two final diagnosis groups schizophrenia versus psychoses month follow average vitamin values deficient fep patients especially final diagnosis schizophrenia results relating vitamin schizophrenia generate interest examine association
volunteer computing type distributed computing ordinary people donate processing storage resources scientific projects boinc main middleware system type computing aim volunteer computing organizations able attain large computing power thanks participation volunteer clients instead high investment infrastructure projects like atlas home project number running jobs reached plateau due high load data servers caused file transfer designed alternative using boinc infrastructure order improve performance boinc projects reached physical limit alternative involves percentage volunteer clients running data servers called data volunteers improve performance reducing load data servers paper describes alternative detail shows performance solution using simulator combos
integrated technology involving computer graphics human computer interaction technology sensor technology artificial intelligence areas use computer generation vivid view listen smell feeling make person participant proper device naturally virtual world experience interact user moves position computer immediately carry complex operations exact world image sent back produce sense presence technique integrates computer graphics technology computer simulation technology artificial intelligence sensor technology display technology network parallel processing technology latest achievements simulation system high technology aided computer technology generation wuhan university science technology south environment virtual space shooting teaching building library gymnasium living quarters roads trees gardens pavilions outdoor scenes generated panorama virtual campus roaming user provide keyboard mouse control means way human computer interaction
based methods stroke rehabilitation mainly focused motor rehabilitation increasing interest towards integration cognitive training providing ecologically valid solutions however studies needed especially definition type content used design tools one possibility use emotional stimuli known enhance attentional processes according socio emotional selectivity theory people age emotional salience arises positive neutral negative stimuli conversely negative stimuli better remembered study investigated impact using emotional stimuli positive negative neutral valence cognitive motor attention task ten stroke patients participated within subjects experiment four conditions based type stimuli abstract control condition positive negative neutral main task consisted finding target stimulus shown two seconds among fourteen neutral distractors eye movements recorded eye tracking system investigate differences conditions search patterns subsequently recall task took place patients identify target images among valence matched number distractors results corroborate attention salience effect positive neutral stimuli task performance although found statistically significant differences conditions recall task trend recalling negative images negative advantage comes expense significantly wrongly identified images false memories negative stimuli finally performed analysis relate performance scores well established cognitive assessment instruments supportsg use approach assessment rehabilitation purposes
vulvar dermatoses seen commonly however unique anatomical physiological structure vulva makes difficult diagnose treat detailed history careful physical examination crucial diagnosis vulvar dermatoses classification vulvar dermatoses international vulvovaginal disease study group also guides clinicians differential diagnosis review vulvar dermatoses reviewed light literature
warp knitted brushed fabrics special pile fabrics uneven declining piles consist broken filament ends difficult predict finial pattern pile surface process design patterned fabric researches computer simulation fabric complicated fuzzy characteristic paper focuses computer simulation group pile fabrics firstly characteristics warp knitted brushed fabric factors influence pile discussed secondly simplified line model proposed represent shape pile lines certain titling angle radial angle length two dimensional matrix used describe position color piles one pattern repeat finally based mathematic model program developed net realize simulation brushed fabric patterned pile input parameters adjusted according craft two dimensional computer simulation pile surface found similar actual patterned pile fabric proved method feasible contributes development computer aided design system realize design simulation warp knitted brushed fabric
waste construction management process identifying analyzing managing waste construction project type waste construction material material like waste time waste cost waste labour etc waste construction causing inefficient activity construction project many practitioners researchers face challenging circumstances finding effective way prevent minimize wastes making best use resources therefore factors need improve waste construction management performance paper proposes new concept assists project managers improve performance level project term waste construction management practice study based identification waste construction management influence factors play important role decreasing waste open questionnaire surveys interviews conducted collate professional opinions key issues definition waste construction variables improve performance waste construction management variables finding based literature interview practitioner construction project result work variables indicators identified improve waste construction management performance variables assets human resources knowledge technology policy result study expectation provide recommendation factor improve construction waste management performance authors published elsevier ltd
wastewater reclamation possesses great potential synchronously solve water pollution water scarcity problems however established reclamation technologies commonly suffer high energy consumption intricate operation hinder widespread applications current study proposed novel capacitive deionization cdi based process achieved simultaneous removal salinity organic matters wastewater two novel types composite electrodes dual layer configuration fabricated basis situ combination approach carbon nanotube cnt activated carbon separately used prepare conductive supporting layer polyvinylidene fluoride pvdf used fabricate membrane selective layer desalination behaviors resultant cnt pvdf carbon pvdf electrodes systematically investigated using lab built electrically enhanced desalination filtration eedf system various model solutions prepared using inorganic substrates sodium alginate bovine serum albumin bsa humic acid evaluate desalination performance different electrodes consequently casting solution containing pvdf selected optimum recipe membrane layer compared cnt layer carbon layer exhibited better desalination performance indicating better alternative composite electrode fabrication desalination behaviors cross flow penetration modes eedf system compared result penetration mode found favorable deionization moreover selective pvdf layer dramatically enhanced selectivity similar also potentially endowed electrode antifouling features suggesting promising applications wastewater reclamation areas
water consumption residential parts urban areas one part water management problems contemporary potable water management sustainable whereas use potable water flushing toilets irrigation washing vehicles appropriate solution substitute potable water rainwater purposes water source considered sustainable submitted paper presents risk assessment using risk analysis rainwater harvesting rwh system paper deal system details informs selected approach evaluation methodology verified analytical hierarchy process authors published elsevier ltd
water consumption likely increase substantially future account rising population economic growth social development rapid urbanization population growth allahabad city necessitated thinking declination ground water level well supply sufficient quantity water future either drinking purpose industrial use present study rainfall recharge allahabad city computed gis platform arcinfo groundwater recharge potential zones allahabad city also found using gis case study recharge ground water roof top rainwater harvesting vikas bhawan multistoryed building allahabad discussed implementation analysis decision making software expected work sustainable water management
water engages two important types interactions near biomolecules forms ordered cages around exposed hydrophobic regions participates hydrogen bonds surface polar groups types interaction critical biomolecular structure function explicitly including appropriate number solvent molecules makes many applications computationally intractable number implicit solvent models developed address problem many treat two solvation effects separately describe new model capture polar solvation effects called sho solvent hydrogen bond occlusion model aims directly evaluate energetic penalty associated displacing discrete first shell water molecules near solute polar group incorporated sho rosetta energy function find scoring protein structures sho provides superior performance loop modeling virtual screening protein structure prediction benchmarks improvements stem fact sho accurately identifies penalizes polar groups participate hydrogen bonds either solvent solute atoms unsatisfied polar groups expect future sho enable higher resolution predictions variety molecular modeling applications wiley periodicals inc
water footprint assessment developing method increasingly applied quantify water use prioritise reductions assess sustainability provide information achieve sustainable efficient equitable water use objectives paper conduct water footprint assessment primary citrus production within lower sundays river valley south africa using local high resolution data examine indicators water scarcity pollution efficiency productivity access determine sustainability blue green grey water footprints wet dry average year lemons found lowest blue combined green blue water footprint per ton production across climatic years followed soft citrus valencias navels valencias lowest navels highest grey relating inorganic nitrogen lemons despite high crop water fertiliser requirements regarded economically efficient comparison valencias soft citrus navels provided higher net income employment hours per water comparison citrus crops average season lemons generated approximately income per water navels despite navels dominant cultivar blue water consumption citrus catchment calculated average season dry season due inter basin transfer scheme physical water scarcity occurred environmental basic human needs met water pollution levels related nitrogen however exceeded assimilative capacity run dry years area also experiences institutional infrastructural scarcity population access piped water stakeholders governments may use results water footprint assessments determine status river basins make evaluations future water usage potential impacts expanding agriculture different management strategies including environmental socio economic indicators also improve integrity water footprint assessments elsevier ltd rights reserved
water mismanagement india causes great havoc many areas receive abundant monsoonal rainfall adequate water domestic uses seasons available time intense urbanization country presents opportunity landscape architects urban designers actively address water security study discusses water use determining metric undisturbed sites greenfield developments abundance water monsoons water scarcity seasons article uses projective design greenfield city naya raipur central india argue rainfall metrics calculate population density water harvesting bylaws order meet per capita domestic water requirements proposed use mandatory per capita water harvesting area easily applicable solution water scarcity provide autonomy households water management control density city based availability water region
water pipes considered one responsible sources water pollution among sources water supply water pipes source carrying fresh processed water lakes ponds streams etc pakistan knowledge condition water pipes scarce deterioration water pipes hardly inspected due high cost aim current research examine quality water pipelines eight districts south punjab namely mianwali khushab layyah bhakkar dera ghazi khan muzaffargarh rajanpur rahim yar khan selected sampling stations analyzed physio chemical parameters total dissolve solids tds sulfate chlorine calcium magnesium hardness nitrate fluoride iron data pertaining water monitoring contain different parameters seem difficult work interpretation water quality managing different parameters separately purpose national sanitation foundation water quality index nsf wqi determined communicate quality water simple form besides groups comprising similar sampling sites based water quality characteristics identified using unsupervised technique factor analysis performed extracting latent pollution sources may cause variance large complex data calculated values wqi sampling stations ranging divided five groups excellent unsuitable class waters average value described good limit drinking water sampling stations divided five optimal clusters selected suitable value obtained silhouette coefficient results means clustering also verified natural groups made wqi analysis multivariate techniques showed several factors responsible water quality deterioration found three latent factors organic pollution agriculture run urban land use caused total variation hence water quality management control latent factors strongly recommended
water pollution generated industrial effluents discharge threat maintenance aquatic ecosystems human development jundiai river estuarine located northeast brazil receives industrial pretreated effluent load city macaiba brazil present study aimed assess water quality water reservoir physicochemical characterization quantification metal concentration iii ecotoxicological assessment carried using mysidopsis juniae pomacea lineata study performed throughout period comprising may september physicochemical variables chloride total solids electrical conductivity presented values waste discharge point significantly different located waste releasing point apart metal concentration showed variable behavior throughout monitored period levels considered guidelines natural anthropogenic sources seem involved resulting environmental scenario reduction fecundity rate usingmysidopsis juniae along increase inmortality rate species observed ratifying presence toxic substances water reservoir moreover correlation analysis stated association aforementioned toxicological effects delivery industrial waste products ecotoxicological assessment performed highlighted presence toxic substance water jundiai river especially consequence industrial activity fact might threaten bioma therefore human health population settled studied region elsevier rights reserved
water pollution gradually increasing natural waters anthropogenic activities study aimed use fish scales bio indicator pollution along water quality parameters assessment detection selected heavy metals water samples collected river chenab including chakbandi drain gathers domestic sewage waste industrial effluents faisalabad deposits freshwater body water quality parameters total dissolved solids tds total suspended solids tss salinity conductivity biochemical oxygen demand bod chemical oxygen demand cod phenols sulphates concentrations selected heavy metals found considerably higher permissible limits defined therefore capable causing ill health effects aquatic organisms specimens fish scales selected fish described qualitatively observed quantitatively catla catla labeo rohita cirrhinus mrigala scales showed several deformities shape different scale structures circuli radii annuli three types fish considerable variation morphology scales observed specimens collected polluted sites
water quality index used express quality water surface well subsurface integrating various water quality parameters present work aimed evaluate seasonal water quality index ooty lake nilgiris district tamilnadu india physico chemical parameter water samples taken two seasons winter summer analyzed categorize level pollution study area results compared water quality standards recommended environment protection act based water quality index multivariate statistical analyses applied identify group parameter influence water quality evaluate type pollution lake addition multivariate statistical analyses factor principal component analysis applied outcome showed three types pollution influencing water quality namely agricultural pollution organic pollution domestic waste water pollution winter season domestic waste water pollution high rainwater flushed areas watershed season lake receives meager amount water hence biological activities taking summer season resulted higher biological pollution analyses observed major impact agricultural pollution cluster analysis showed three cluster values similarity groups among sampling sites noticed direct discharge improper drainage system watershed caused pollution lakes
water responsive sio cellulose nanocomposite hydrogels films constructed first time dispersing sio nanoparticles cellulose solution lioh urea solvent crosslinking epichlorohydrin regeneration coagulation bath respectively cellulose nanocomposite materials characterized field emission scanning electron microscopy ftir dynamic rheology wide angle ray diffraction mechanical test sio cellulose nanocomposites wet state water displayed unique behaviors showing higher light transmittance contacting water results revealed strong hydrogen bonding interaction among water cellulose sio led good dispersion sio nanoparticles cellulose matrix incorporation sio nanoparticles improved transmittance mechanical strength cellulose hydrogels also enhanced mechanical strength films especially cellulose sio nanocomposite films milky dry state changed transparent soaked water different cellulose film without sio nanoparticles findings sio cellulose water could form strong hydrogen bonding create homogenous network structure cellulose sio composite smart material exhibited moisture solvent responsiveness showing potential applications moisture detection
water reuse schemes urban water system assessed paper number hydraulic performance indicators city metabolism model watermet used evaluate performance water reuse schemes multi objective evolutionary algorithm employed identify pareto optimal solutions following three objectives resilience reliability total cost demonstration suggested approach real world case study show importance using resilience index determining appropriate schemes results suggest case analysed rainwater harvesting scheme plays significant role improvement resilience index authors published elsevier ltd
water scarcity increasingly constrains agricultural production particularly rice one important food crops conventional paddy production world largest single consumer water making certain changes current cultivation practices discussed raise rice crop yields reducing water inputs diminished greenhouse gas ghg emissions less runoff water pollution climate resilience additional benefits spreading changes crop water management within rice sector cost effective response agricultural water shortages offering improvement food security adaptability climate change environmental sustainability elsevier rights reserved
water splitting key step towards artificial photosystems solar energy conversion storage form chemical bonding oxidation water bottle neck process hampers practical utility hence efficient robust easy make catalytic systems based cheap earth abundant materials exceptional importance herein situ generated cobalt catalyst tca tca mesityl triazole carboxylate efficiently conducts photochemical water oxidation near neutral conditions presented catalyst showed high stability photolytic conditions photoirradiation electrochemical water oxidation catalytic system assembled catalyst film proved cobalt oxide hydroxide normally expected instead first time generated molecular cobalt complex incorporated organic ligand bound cobalt ions catalyst film exhibited low overpotential electrocatalytic water oxidation high oxygen evolution peak current densities glassy carbon indium doped tin oxide electrodes respectively versus normal hydrogen electrode respectively neutral conditions finding exemplified situ generated cobalt complex might applicable molecular systems suggests formation catalytic film electrochemical water oxidation experiments always indication catalyst decomposition formation nanoparticles
water transport soils atmosphere critical plant growth survival however limited understanding many portions whole tree hydraulic pathway vast majority published information terminal branches understanding mature tree trunk hydraulic physiology particular limited hydraulic vulnerability segmentation hypothesis hvsh stipulates distal portions plant leaves branches roots vulnerable embolism trunks nonredundant organs require massive carbon investment current study compared vulnerability loss hydraulic function leaf xylem water potentials resulting hydraulic safety margins relation water potential causing loss hydraulic conductivity leaves branches trunks roots four angiosperms four conifer tree species across species results supported strongly hvsh leaves roots less resistant embolism branches trunks however branches consistently resistant embolism portion plant including trunks also calculated whole tree vulnerability hydraulic dysfunction much greater vulnerability branches due hydraulic dysfunction roots leaves less negative water potentials causing branch trunk dysfunction leaves roots narrow negative hydraulic safety margins trunks branches maintained positive safety margins using branch based hydraulic information proxy entire plants much research potentially overestimated embolism resistance possibly drought tolerance many species study highlights necessity reconsider past conclusions made plant resistance drought based branch xylem study also highlights necessity research whole plant hydraulic physiology better understand strategies plant drought tolerance critical control points within hydraulic pathway
wave energy promising source renewable energy usage limited nature sea waves deliver slow reciprocating movement reason linear electrical generators perfectly suit application geared systems used order make generator compact suffer low reliability require regular maintenance direct drive systems reliable less efficient terms mass power ratio generator topology called vernier electrical generator utilizes principle magnetic harmonic gear high mass power ratio low speed require separate gearing unit however vernier generators notorious high phase inductance considerable limits power paper describes design topology linear permanent magnets vernier electrical generator lpmveg relatively low phase inductance electronic unit function compensation reactive power collaborative design generator power electronics allows achieving higher mass power ratio proposed device
wave energy one promising renewable generation sources paper presents model optimise layout electrical network collects energy generated wave farm goal minimise cost installation losses several combinations among transmission available optimization algorithms easily reach local minimums order avoid niche evolutionary algorithm proposed
wave theories heating chromosphere corona solar wind due photospheric fluctuations strengthened existence wave coherency observed transition region coherency intensity oscillations solar spicules explored using solar optical telescope sot hinode spacecraft increasing height solar limb active region used time sequences near south east region hinode sot line obtained april applied convolution procedure spicule illustrate effectively restoration method works fine structures spicules moreover intensity oscillations different heights solar limb analysed wavelet transforms afterwards phase difference measured oscillations two heights search evidence coherent oscillations results wavelet transformations revealed dominant period peaks min four separate heights dominant frequencies coherency level higher per cent found around mhz mean phase speeds measured found mean phase speeds increased height results suggest energy flux carried coherent waves corona heliosphere may several times larger previous estimates based solely constant velocities provide compelling evidence existence upwardly propagating coherent waves
waves carry energy force momentum therefore colliding wave trains physical capacity interact form maintain standing waves standing waves form liquids gases electrical circuits electromagnetic waves wave behavior exists irrespective media type investigated possibility waves various media interact common physical mechanism propose standing waves composed alternating segments reflection zones potential energy resides little lateral energy flow kinetic energy zones lateral energy flow maximal interference patterns form waves collide collision two force vectors resolve one longitudinal vector forms along direction bisect convergence angle direction vector sum two converging wave trains second vector derived colliding wave forces acting transverse orthogonal longitudinal vector transverse acting forces produce standing wave component action standing wave components separates longitudinal moving waves transversely parallel zones energy primarily potential one zone kinetic next example interference pattern formed converging trains light waves potential energy resides longitudinal dark zones null zones kinetic energy parallel bright zones experiments using two converging laser beams produced evidence colliding forces standing waves redirect concentrate light energy without using lenses
aim review available literature obese patients treated bariatric procedures order assess effect metabolic gut microbiota profiles systematic literature search performed pubmed cochrane library scopus databases accordance prisma guidelines twenty two studies patients met inclusion criteria study points significant amelioration postoperative levels glucose insulin triglycerides total cholesterol ldl hdl homa food intake diabetes remission branched chain amino acids bcaas decreased trimethylamine oxide tmao glucagon like peptide glp glp peptide pyy increased postoperatively postoperative gut microbiota similar lean less obese objects well designed randomized trials necessary assess host metabolic microbial cross talk bariatric procedures
aimed characterize parent experience caring infant neonatal encephalopathy mixed methods study performed semistructured interviews parents whose infants enrolled existing longitudinal cohort study therapeutic hypothermia thematic saturation achieved interviews parent experience caring child neonatal encephalopathy characterized principal themes theme many families described cumulative loss grief throughout perinatal crisis critical neonatal course subsequent missed developmental milestones theme families experienced entangled infant broader family interests theme parents evolved found meaning role advocate data offer insight lived experience parenting infant neonatal encephalopathy primary data parents serve useful framework guide development interpretation parent centered outcomes
aimed determine risk alopecia areata vitiligo associated atopic dermatitis large cohort women nurses health study used logistic regression calculate age multivariate adjusted odds ratios determine risk incident vitiligo associated diagnosed total participants included vitiligo analyses respectively history reported participants incident cases incident cases vitiligo years follow associated increased risk developing vitiligo multivariate models study women associated increased risk incident vitiligo adulthood
analyze development investigations scientific results field physicochemical mechanics materials plays role contemporary scientific direction materials science main stages development direction ukrainian national academy sciences considered role karpenko formation development branch science described also synthesize important scientific results illustrate practical applications formulate urgent problems future investigations
analyze security two way continuous variable quantum key distribution protocol reverse reconciliation general two mode attacks represent accessible attacks fixed channel parameters rather one specific attack model expression secret key rates two way protocol derived accessible attack models found optimal two mode attack minimize performance protocol terms secret key rates maximal transmission distances identify optimal two mode attack give specific attack model optimal two mode attack show performance two way protocol optimal two mode attack even optimal two mode attack performances two way protocol still better corresponding one way protocol shows advantage making double use quantum channel potential long distance secure communication using two way protocol
analyze state development practices mesh generation mesh processing mgmp software comparing mgmp projects analysis employs reproducible method based grading template questions covering software qualities software ranked using analytic hierarchy process ahp multicriteria decision making method appropriate cases mix qualitative quantitative factors results reveal concerns regarding maintainability usability reusability performance mgmp software five recommendations presented feedback mgmp community use issue tracker bug management support requests document performance measures iii increase use libraries promote software use avoid inventing wheel improve reproducibility recording set details development testing environments improve confidence correctness requirements specification formal specification languages automated testing elsevier ltd rights reserved
expect number internet things iot devices rapidly increase part due availability low cost powerful hardware advances hardware introduce new class computer commodity low cost single board computer sbc example raspberry devices capable running full operating system accessible non technical users paper demonstrate feasibility using class computer construct iot devices without deep technical knowledge embedded systems iot device targeted real world data collection basis deployed device discover although existing sbc hardware market varies dramatically much applicable iot scenarios generally default box configuration supports one linux variants highlevel programming languages standard hardware libraries configurable attractively priced predict growth using class computer particularly iot prototypes disposable compute low hardware volume scenarios future expect hardware improvements enhanced operating systems taking account issues surrounding iot devices card storage corruptions power consumption improved failure detection
learn affective content environment observing behavior others responses stimuli tend appropriate context investigate impact observing appropriate compared inappropriate behaviors developed novel behavioral task participants observed different faces reacting emotional scenes found affective categorization scene facilitated presented alongside appropriate facial expression experiment observed several brain areas right hemisphere putamen insula orbitofrontal cortex dorsal anterior cingulate cortex activate viewing faces previously observed emoting inappropriately experiment contend areas form network codes retrieval affective conflict information generated observing individuals producing inappropriate emotions
collected short video clips speakers created five types stimuli original videos audio tracks single pictures speech content stick figure animations displaying body motion participants rated stimuli brief big five personality inventory used ratings incomplete information conditions predict ratings original video condition impressions audio track condition strong predictors throughout trait ratings however cues also non negligible contributors overall impression people even make sense parsimonious cues animated stick figure thus presenters public stage judged say also move authors published elsevier inc
compared persistence overactive bladder oab pharmacotherapy patients treated female pelvic medicine reconstructive surgery fpmrs department compared patients treated internal medicine general urology departments within integrated health care system hypothesized persistence would higher among fpmrs patients retrospective cohort study patients least one prescription oab january july identified demographic prescription treatment specialty data data use third line therapies collected primary outcome persistence defined days continuous pharmacotherapy discontinuation defined treatment gap days discontinuation free probabilities calculated using kaplan meier method compared among specialties predictors persistence estimated using logistic regression adjustment covariates pearson correlation coefficients calculated identify risk associations total subjects identified weeks months year fpmrs patients highest persistence rates contrast patients patients respectively median persistence fpmrs patients days patients days patients days fpmrs patients switched least second medication compared patients patients persistence oab pharmacotherapy higher among fpmrs patients among patients community setting results suggest persistence higher subspecialist supervision
conducted comprehensive review literature establish evidence base using visual activity schedules vas individuals intellectual disability literature published evaluated quality using criteria developed horner total studies included acceptable findings suggest vas evidence based practice teaching variety daily living navigation vocational recreation academic skills adolescents adults intellectual disability results also show increases independence task behaviors conclude article discussing limitations recommendations future research
conducted meta analysis single subject research studies investigating effectiveness antecedent strategies grounded behavioral momentum improving compliance task performance students autism first assessed research rigor studies meeting inclusionary criteria next order apply universal metric help determine effectiveness category antecedent strategies investigated via single subject research methods calculated effect sizes via omnibus improvement rate differences irds outcomes provide additional support behavioral momentum especially interventions incorporating high probability command sequence implications research practice discussed including consideration single subject research systematically reviewed assess rigor studies assist determining overall intervention effectiveness
conducted multicenter randomized controlled trial evaluate impact population based patient centered post fracture care program dedicated case manager prevention osteoporosis prevost appropriate post fracture osteoporosis management showed compared usual care bmd investigation post fracture significantly improved intervention program study aims evaluate impact population based patient centered post fracture care program prevost appropriate post fracture care multicenter randomized controlled trial enrolling women aged years attending french hospital low energy fracture wrist humerus randomization stratified age hospital department site fracture intervention performed trained case manager interacted patients repeated oral written information fragility fractures osteoporosis management prompting visit primary care physicians control group received usual care primary outcome initiation appropriate post fracture care defined bone mineral density bmd anti osteoporotic treatment prescription months months women intervention group initiated post fracture care versus usual care adjor post fracture care frequent wrist humerus fracture adjor decreased age adjor years increase intervention resulted bmd prescription patients adjor bmd performance patients adjor versus usual care respectively performed bmd increased treatment prescription however women low bmd requiring treatment according french guidelines received prescription patient centered care program dedicated case manager significantly improve post fracture bmd investigation
conducted survival analysis competing risks estimate mortality rate predictive factors immunodeficiency related death people living hiv aids plwh northeast brazil cohort plwh enrolled july june monitored december two healthcare centres event interest immunodeficiency related death defined based coding causes death hiv protocol code predictor variables sociodemographic characteristics illicit drugs tobacco alcohol nutritional status antiretroviral therapy anaemia cell count baseline treatment chemoprophylaxis tuberculosis follow used fine gray model survival analyses competing risks since regarded immunodeficiency unrelated deaths competing event estimated adjusted sub distribution hazard ratios shrs person years observation deaths person years immunodeficiency related immunodeficiency unrelated shr anaemia shr cells shr unemployed shr risk factors immunodeficiency related death study discloses coverage highly active antiretroviral therapy haart state adds anaemia baseline incidence may increase specific risk dying hiv immunodeficiency regardless haart
conducted observational cross section study investigate status bone mineral mass tibetan postmenopausal women type diabetes possible predictors osteoporosis found prevalence osteoporosis blood pressure independent risk factor bone mass loss aims study investigate prevalence osteoporosis postmenopausal women type diabetes dwelling tibet possible risk factors bone mass loss recruited chinese tibetan postmenopausal women type diabetes department endocrinology people hospital tibet autonomous region multiple sites bone mineral density bmd measured dual energy ray absorptiometry dxa subjects divided three groups based bmd score osteoporosis osteopenia normal clinical characteristics compared groups risk factors bone mass loss assessed multiple linear regression analysis among diabetic postmenopausal women dwelling high altitude mean age years median postmenopausal period years median duration diabetes mellitus years mean bmi patients hypertension percentages patients osteoporosis osteopenia normal bmd respectively hbac systolic blood pressure sbp independently associated scores spine ages sbp independently associated scores femoral neck hip among diabetic postmenopausal women dwelling high altitude patients osteoporosis patients osteopenia normal bmd score spine inversely associated sbp positively associated hbac bmd score femoral neck hip inversely associated ages sbp
consider network agents whose objective aggregate states converge solution linear program standard form agent limited information problem data communicate agents discrete time instants choosing main contribution synthesis distributed dynamics set state based rules termed triggers individual agents use determine opportunistically broadcast state neighboring agents ensure asymptotic convergence solution linear program technical approach algorithm design analysis overcomes number challenges including establishing convergence absence common smooth lyapunov function ensuring triggers detectable agents using local information accounting asynchronism state broadcasts ruling various causes arbitrarily fast state broadcasting various simulations illustrate results
consider population dynamic agents also referred players state player evolves according linear stochastic differential equation driven brownian motion influence control adversarial disturbance every player minimizes cost functional involves quadratic terms state control plus cross coupling mean field term measuring congestion resulting collective behavior motivates term crowd averse motivations model analyzed discussed three main contexts stock market application production engineering example dynamic demand management problem power systems problem abstract formulation illustrate paradigm robust mean field games main contributions involve first formulation problem robust mean field game second development new approximate solution approach based extension state space third relaxation method minimize approximation error results provided scalar case establish performance bounds analyze stochastic stability microscopic macroscopic dynamics
consider dynamic group services outputs based small samples privacy sensitive user inputs repetitively computed leakage user input data analysed caused producing multiple outputs resulting inputs frequently changing sets users cryptographic technique known random user selection investigated show effect random user selection given different types output functions thereby disproving earlier work new security measure introduced provably improves privacy preserving effect random user selection irrespective output function show new security measure implemented existing cryptographic protocols investigate effectiveness security measure conducted couple statistical simulations large user populations show forms key ingredient least output function addition without adversary able determine user input increasing accuracy outputs become available security measure implemented adversary remains oblivious user inputs even thousands outputs collected therefore new security measure assures random user selection effective way protecting privacy dynamic group services
consider free surface flow two localised obstacles using framework forced korteweg vries equation suite numerical simulations main concern transcritical regime oncoming flow froude number close unity flow behaviour characterised froude number maximum heights obstacles transcritical regime early times undular bores produced upstream downstream obstacle main aim describe interaction undular bores obstacles find outcome large times find flow development defined three stages first stage described well known development undular bores upstream downstream obstacle file second stage interaction undular bore moving downstream first obstacle undular bore moving upstream second obstacle third stage large time evolution interaction one obstacles controls criticality equal obstacle heights analytical numerical results indicate either one obstacles control flow criticality first obstacle flow slightly suhcritical second obstacle otherwise unequal obstacle heights larger obstacle controls criticality fhe results obtained complement recent numerical study using fully nonlinear non dispersive shallow water equations
consider state space representation multivariate dynamic process markov switching measurement transition equations appropriate moment conditions show autocovariance structure process coincides stable varma model potentially useful statistical applications model selection example identification regime number applications classical markov switching models numerical illustrations complete paper
consider integrable generalization nonlinear schrodinger equation arises model nonlinear pulse propagation monomode optical fibers existent conditions modulational instability form rogue waves given plane wave solutions propose generalized fold darboux transformation system using nth order darboux matrix taylor expansion limit procedure application use generalized perturbation fold darboux transformation generate higher order rogue wave solutions system dynamics behavior first second third order rouge wave solutions shown graphically results may useful understanding physical phenomena optical fibers
consider problem efficient content delivery networks individual nodes equipped content caching capabilities present flexible methodology design cooperative decentralized caching strategies adapt real time changes regional content popularity design methodology makes use recently proposed reduced consensus optimization scheme number networked agents cooperate locating optimum sum individual privately known objective functions outcome design set dynamic update rules stipulate much portions content piece individual network node ought cache implementing update rules nodes achieve collectively optimal caching configuration nearest neighbor interactions measurements local content request rates moreover individual nodes need aware overall network topology many nodes network desired caching behavior encoded design individual nodes costs incorporate variety network performance criteria using proposed methodology develop set content caching update rules designed minimize energy consumption network whole dynamically trading transport caching energy costs response changes content demand
continue explore scaling transformation reduced action formalism gravity models extension construction consider extended forms smarr relation various black holes adopting cosmological constant bulk pressure literatures black holes firstly using quasi local formalism charges show general theory gravity volume black hole thermodynamics could defined thermodynamic conjugate variable bulk pressure way first law extended consistently called thermodynamic volume expressed explicitly terms metric field variables using scaling transformation allowed reduced action formulation obtain extended smarr relation involving bulk pressure thermodynamic volume approach resort euler homogeneous scaling charges incorporating would hairy contribution without difficulty
created simulation model investigate potential links actions violent extremist organizations veos people veo home country diaspora communities country living west created model using dymatica framework uses hybrid cognitive system dynamics modeling strategy simulate behaviors based psycho social theory initial results model given focusing increases veo funding recruiting resulting invasion veo home country western intervention prejudice economic drivers also considered
created conditions necessary cognitive representations develop presenting individuals groups word lists consisting items high low associative strength strong cognitive representations found promote schema consistent memory errors weaker representations moreover strong cognitive representations resulted errors groups individuals weak cognitive representations contrast resulted fewer errors groups individuals find variation frequency memory errors individuals groups influenced strength shared representations interfere ability groups correct schema consistent memory errors among members analyses suggest strong shared representations also aid correct recall relative weak shared representations conclude despite general advantages collaboration select circumstances allow strong shared representations may promote schema consistent memory errors groups
derive model wind turbine tower plane turbine blades comprises euler bernoulli beam coupled nacelle rigid body two mass drive train model gearbox model two possible control inputs torque created electrical generator force created electrically driven mass located nacelle first consider case torque control possibly non uniform tower using theory coupled linear systems one infinite dimensional one finite dimensional developed recently show wind turbine tower model well posed regular either energy state space domain generator denoted also show generically model exactly controllable arbitrarily short time precisely every show vary certain parameter model exact controllability time holds except three values parameter case using force torque control derive similar well posedness regularity generic exact controllability results state space larger smaller second case assume tower uniform
derive unified graph theoretic approach continuous discrete phase type distributions algorithms given obtain signal flow graph directly either matrix representation distribution transition diagram underlying markov chain transfer function signal flow graph easily computable using mason rule gives characteristic function phase type distribution symbolic form proposed approach intrinsically includes non trivial initial probabilities states moreover continuous case results graphs simpler obtain found literature finally show approximate discrete counterpart continuous phase type distribution viewed forward difference euler mapping continuous discrete time domains elsevier rights reserved
describe architectures audio classification front ends reconfigurable analog platform real time implementation audio processing algorithms involving discrete time signals tend power intensive present alternate continuous time system implementation noise suppression algorithm reconfigurable chip detailing design considerations also describe framework enables future implementations speech processing algorithms classifier front ends hearing aids
describe swarmsight available https github com justasb swarmsight novel open source microsoft windows software tool quantitative assessment temporal progression animal group activity levels recorded videos tool utilizes background subtraction machine vision algorithm provides activity metric used quantitatively assess compare animal group behavior demonstrate tool utility analyzing defensive bee behavior modulated alarm pheromones wild bird feeding onset interruption cockroach nest finding activity although sophisticated commercial software packages available swarmsight provides low cost opensource easy use alternative suitable wide range users including minimally trained research technicians behavioral science undergraduate students classroom laboratory settings
design synthesize novel graphene embedded orient assembled tio mesoporous spheres composite oatms evidenced sem tem optical spectra mesoporous structure characteristics single crystal like tio mixed phases anatase rutile embedding graphene integrated composite system investigate structure property relationship enhancing photocatalytic activity three dimensional open mesoporous tio microspheres well constructed radially oriented self assembly single crystal like tio nanowires aggregation nanowires leads formation hierarchical microsphere including mesopores convenient light harvesting adsorption reaction molecules especially phase ratio anatase rutile composite readily tunable change reaction agents incorporation graphene accelerates electron transfer prolongs lifetime photoinduced electron hole pairs unique structure makes composite ideal efficient photocatalyst removal pollutants oatms composite degradation nitric oxide shows excellently photocatalytic activity stability photocatalytic reaction results presented expected make contribution preparing delicately photocatalytic nanocomposites toward promising applications air purification solar energy utilization elsevier rights reserved
determined whether time domain amplitude time frequency principal component reductions could serve stable predictive developmental endophenotypes externalizing psychopathology participants minnesota twin family study assessed age age lifetime externalizing ext disorders comparisons amplitude pcs delta theta frequencies made ext unaffected comparison subjects amplitude five extracted pcs significantly reduced presenting lifetime ext disorders ages showed substantial year rank order stability amplitude delta pcs measured age also predicted subsequent development ext age every microvolt decrease age amplitude associated approximately increase risk ext diagnosis age overall results study confirm derived brain measures maintain potential putative ext endophenotypes third decade life
disclose studies preceded guided preparation metal based redox active therapeutic iii meso tetrakis butoxyethylpyridyl porphyrin mntnbuoe pyp bmx currently phase clinical trials duke university usa radioprotector normal tissues cancer patients substituted pyridylporphyrins ligands iii complexes among potent superoxide dismutase mimics thus far synthesized advance design thereby improving physical chemical properties bioavailability toxicity profiles undertook systematic study placing oxygen atoms nalkylpyridyl chains via alkoxyalkylation reaction first time show unforeseen structural rearrangement happens alkoxyalkylation reaction corresponding tosylates comprehensive experimental computational approaches employed solve rearrangement mechanism involved quaternization pyridyl nitrogens instead single product led variety mixed nalkoxyalkylated allcylated pyridylporphyrins rearrangement mechanism involves formation intermediate alkyl oxonium cation chain length dependent manner subsequently drives differential kinetics thermodynamics competing alkoxyalkylation versus situ alkylation use alkoxyalkyl tosylates different length alkyl fragments adjacent oxygen atom allowed identify set alkyl fragments would result synthesis single compound high purity excellent therapeutic potential elsevier inc rights reserved
discuss way using keyword search case connected relational databases peer agent deciding translation propagation keyword query well way merging partial answers way merging partial total essential efficiency execution information contents final answer prove theorem stating necessary condition deciding strategy merging made peer
evaluated attachment theory model mother father care hypothesized indirectly related body dissatisfaction mediated attachment anxiety media internalization participants women diagnosed eating disorder completed retrospective measure parental bonds measures attachment anxiety media internalization body image mother care negatively associated body dissatisfaction suggesting recollection mothers less caring directly related poorer body image lower father care indirectly associated greater body dissatisfaction mediated higher attachment anxiety higher media internalization women eating disorder recollected fathers less caring higher attachment anxiety related greater internalizing media related thin ideals turn associated poorer body image mothers fathers may impact body dissatisfaction differing mechanisms clinical samples elsevier ltd rights reserved
evaluated accuracy peer ratings roommates personality characteristics roommate self ratings function rating domain observability instead usual ratings broad personality traits however domains represented peer ratings narrow exemplars personality traits specifically compared roommate ratings observable trait related behaviors unobservable trait related attitudes beliefs observed greater self peer agreement rating behaviors general rating beliefs also observed greater tendency raters adopt assumed similarity heuristic judging roommates attitudes beliefs behaviors discuss contribution findings understanding determinants accuracy personality judgments developing best practices personality assessment elsevier inc rights reserved
evaluated preoperative prevalence risk factors liver disorders relationship liver disorders perioperative outcomes adult congenital heart disease achd patients retrospective study included achd patients underwent reoperative cardiac surgery preoperatively study patients risk factors including congestive liver due right heart failure chronic hepatitis numbers patients child pugh scores median range preoperative platelet count fibrinogen values respectively patients higher child pugh scores tended longer duration anesthesia surgery respectively significantly higher platelet transfusion lower platelet count associated longer duration anesthesia surgery cardio pulmonary bypass cpb larger amount blood loss platelet transfusion lower fibrinogen value associated longer duration anesthesia surgery cpb larger amount platelet transfusion achd patients underwent reoperative cardiac surgery high prevalence risk factors liver disorders preoperatively liver disorders aggravated intraoperative outcomes findings suggest prevention liver disorders important reducing occurrence poor outcomes achd patients liver disorders need attentive perioperative management
examine use automatic adaptation user grasp facial direction interaction game two experimental studies conducted first experiment identified patterns grasp facial direction used objective indicators intentions attention results indicate participants grasp remote control according intended use turn face towards object intend interact amount time participants turned faces towards object influenced available visual information second experiment used patterns identified experiment create game adapted grasp facial direction compared two adaptive games purely command based game results show participants adaptive versions game significantly faster made fewer errors rate feeling control higher positive affective experience
examined live coronal slices rat mouse brain regions generate potassium triggered spreading depolarization sdkt technique simulates cortical spreading depression underlies migraine aura intact brain sdkt episode evoked increasing bath recorded propagating front elevated light transmittance representing transient neuronal swelling gray matter neocortex hippocampus striatum thalamus contrast sdkt imaged hypothalamic nuclei brainstem exception nuclei near dorsal brainstem surface rat slices single neurons whole cell current clamped sdkt higher neurons depolarized near zero millivolts indicating sdkt generation contrast seven types neurons hypothalamus brainstem slowly depolarized without generating sdkt supporting imaging findings therefore sdkt default cns neurons rather displays region specific susceptibility similar anoxic depolarization proposed correlated region vulnerability traumatic brain injury higher brain sdkt may vestigial spreading depolarization originally evolved shut vasoconstrict gray matter regions exposed impact contusion
examined association forced sex history mental health sexual health substance use among asian american women sample reported forced sex experiences multiple logistic regression analyses revealed participants forced sex histories times likely higher rates mental health problems hiv risk behavior substance use qualitative analysis used supplement quantitative results give depth findings results suggest interventions asian american women experienced forced sex integrate mental health substance use sexual health treatments
examined error related negativity ern endophenotype asd comparing ern families asd probands control families hypothesized asd probands families would display reduced amplitude ern relative controls participants included individuals within families consisting mother father sibling proband robust anovas revealed non significant differences ern amplitude behavioral performance among asd probands relative control youth subsequent multiple regression analyses group kinship proband sibling mother father significantly predict delta ern error minus correct ern behavioral performance results provide evidence ern endophenotype asd future research needed examine state trait related factors influencing ern amplitudes asd
examined influence interdependence goals accessibility implicit gender stereotypical associations participants asked cooperate compete woman mathematical abilities task subsequently relative activation positive negative warmth competence traits measured using primed categorization task results showed female primes male primes facilitated activation low warmth high competence competition condition whereas high warmth activated cooperation condition differences found competence traits results discussed referring stereotype content model compensation effect person perception goal dependent nature implicit gender stereotypes emphasized
examined lifetime experience hallucinations delusions associated transient methamphetamine related psychosis map persistent map primary psychosis among cohort dependent methamphetamine users participants classified current psychotic symptoms psychotic symptoms using methamphetamine transient map psychotic symptoms using methamphetamine abstaining methamphetamine persistent map meeting dsm criteria lifetime schizophrenia mania primary psychosis current psychotic symptoms classified score brief psychiatric rating scale items suspiciousness hallucinations unusual thought content past month lifetime psychotic diagnoses symptoms assessed using composite international diagnostic interview transient map associated persecutory delusions tactile hallucinations compared symptom group persistent map additionally associated delusions reference thought interference complex auditory visual olfactory tactile hallucinations primary psychosis also associated delusions thought projection erotomania passivity presence non persecutory delusions hallucinations across various modalities marker persistent map primary psychosis people use methamphetamine
examined links parental elaborativeness children suggestibility salient event testing hypothesis accuracy focused context children elaborative parents resistant false suggestions children less elaborative parents hypothesis supported sample year old children caregivers parent elaborativeness along children working memory additively predicted resistance false suggestions unfamiliar interviewer peripheral details alleged transgression children forthcoming transgression actually occurred highly resistant suggestions transgression took place results implications understanding parents socialize children resist suggestions accuracy focused contexts everyday reminiscing practices implications theories narrative memory development applied contexts legal system discussed elsevier inc rights reserved
explore formal managers centralities positive negative networks predict followers perceptions leadership incorporating social networks social ledger theory implicit leadership theories ilt hypothesize formally assigned group leaders managers positive advice ties fewer negative avoidance ties likely recognized leaders followers posit managers informal networks bring greater social power important attribute differentiating leaders non leaders conducted two survey based studies student field teams test hypotheses based nested data studies found support hypotheses results remain robust across two studies even though used different designs cross sectional versus longitudinal different samples field versus students across different countries united states versus india host control variables leader follower levels find managers central advice network socially powerful seen leaders individual followers contrast managers avoided followers lack informal social power seen leaders conclude discussing theoretical practical implications findings ways theory results extend ilts social network theory elsevier inc rights reserved
explore two dimensional flow around circular cylinder aim elucidating changes topology vorticity field lead formation karman vortex street specifically analyse formation disappearance extremal points vorticity consider feature points vortices basic vortex creation mechanism shown topological cusp bifurcation vorticity field saddle extremum vorticity created simultaneously demonstrate vortices first created approximately diameters downstream cylinder reynolds number slightly larger critical reynolds number ecrit approximate flow becomes time periodic slightly newly created vortices disappear short distance downstream increased points creation disappearance move rapidly upstream downstream respectively karman vortex street persists increasingly large streamwise distances
explored relation shyness social anxiety disorder sad investigating role sociability association using multicomponent approach found sociability moderated association shyness sad adults individuals experience conflicted shyness scoring high shyness sociability displayed greatest disturbance across cognitive behavioral somatic components sad findings lend support notion shyness broad heterogeneous construct highly shy individuals meet diagnostic criteria sad adults conflicted shyness phenotype represent subgroup shy individuals may particular risk sad symptoms finding provides empirical support approach avoidance conflict may motivational underpinning development sad elsevier ltd rights reserved
explored relationship sleep patterns sleep disorders mammographic density marker breast cancer risk participants ddm spain var ddm study included middle aged spanish women interviewed via telephone asked questions sleep characteristics two radiologists assessed left craneo caudal mammogram assisted validated semiautomatic computer tool scan used log transformed percentage dependent variable fitted mixed linear regression models including known confounding variables results showed neither sleeping patterns sleep disorders associated however women frequent changes bedtime due anxiety depression higher beta elsevier rights reserved
extended current density convolution finite difference time domain jec fdtd method plasma photonic crystals using crank nicolson difference scheme derived one dimensional jec crank nicolson fdtd iterative equation plasma photonic crystals method eliminated courant friedrich levy cfl stability constraint became completely unconditional stable form incomplete cholesky conjugate gradient iccg algorithm proposed solve equation large sparse matrix fdtd method iccg method improves speed convergence enhances stability reduces memory consumption jec fdtd method applied study characteristics time domain frequency domain plasma photonic crystal objects high accuracy efficiency jec fdtd method confirmed computing characteristic parameters plasma photonic crystals different conditions electric field distribution electromagnetic wave reflection coefficients transmission coefficients simulation study showed algorithm performed stably could reduce memory consumption facilitate computer programming
extended use microswitch cluster technology six children severe profound developmental disabilities autism spectrum disorders primary aim intervention improve adaptive behavior insert three objects three different containers within simultaneously decrease challenging behavior hand objects mouthing second aim assess effects intervention indices happiness abcac experimental sequence adopted participant thus subsequent baseline condition first intervention phase implemented increasing adaptive responding irrespective challenging behavior followed cluster phase positive stimulation provided contingent adaptive response challenging behavior absent month follow occurred results showed performance improvement participants involved additionally consolidated adaptive responding follow sixty external raters favorably endorsed use technology implications findings discussed
face increasing need discover knowledge data streams real time real time stream data mining needs compact data structure store transactions recent sliding window one scan efficient algorithm discover frequent itemsets compact data structure paper propose novel data mining algorithm called cantree gtree discovers complete frequent itemsets real time transactions based sliding windows algorithm uses two data structures cantree gtree cantree compactly represents transactions sliding window one scan serves base tree algorithm efficiently maintains base tree adding new transactions removing old transactions without reconstruction phases novel data structure called gtree group tree serves projection tree data item algorithm traverses node base tree using top tree traversal method build projection tree discovers frequent itemsets low processing cost proposed algorithm therefore effective discovering frequent itemsets real time stream data performance evaluation experiments algorithms based cpstree cantree fptree show algorithm outperforms algorithms synthetic data set run time cost respectively also confirm proposed algorithm shows excellent results real world data sets elsevier inc rights reserved
observed quench lasing exceptional point electronic circuit system applying asymmetric gain coupled oscillators analogy oscillation laser oscillation operational amplifier oscillation stops system hits exceptional point phenomenon also theoretically investigated
explore first time advanced multiscale mathematical modeling approach may support design provenly successful tissue engineering concept mandibular bone latter employs double porous potentially cracked single millimeter sized granules packed overall conglomerate type scaffold material gradually penetrated partially replaced newly grown bone tissue process newly developing scaffold bone compound needs attain stiffness mandibular bone normal physiological conditions context question arises compound stiffness driven key design parameters tissue engineering system macroporosity crack density well scaffold resorption bone formation rates tackle question combining latest state art mathematical modeling techniques field multiscale micromechanics unprecedented suite highly efficient semi analytically defined computation steps resolving several levels hierarchical organization millimeter nanometer scale includes several types homogenization schemes namely porous polycrystals elongated solid elements cracked matrix inclusion composites well assemblies coated spherical compounds together experimentally known stiffnesses hydroxyapatite crystals mandibular bone tissue new mathematical model suggests early stiffness recovery within several weeks requires total avoidance microcracks hydroxyapatite scaffolds mid term stiffness recovery within several months additionally promoted provision small granule sizes combination high bone formation low scaffold resorption rates
present development validation verbal affective memory test vamt first ensured face validity selecting words reliably perceived positive negative neutral respectively according healthy danish adults valence ratings common non taboo words second studied test psychometric properties healthy adults finally investigated whether individuals diagnosed seasonal affective disorder sad differed healthy controls seasonal changes affective recall recall rates internally consistent reliable converged satisfactorily established non affective verbal tests immediate recall imr positive words exceeded imr negative words healthy sample relatedly individuals sad showed significantly larger decrease positive recall summer winter healthy controls furthermore larger seasonal decreases positive recall significantly predicted larger increases depressive symptoms retest reliability satisfactory conclusion vamt thoroughly developed validated existing verbal affective memory tests showed satisfactory psychometric properties vamt seems especially sensitive measuring positive verbal recall bias perhaps due application common non taboo words based psychometric clinical results recommend vamt international translations studies affective memory
herein describe novel fluorescent method rapid selective detection adenosine utilizing dna templated nanoclusters ncs employing adenosylhomocysteine hydrolase sahh sahh allowed promote hydrolysis reaction adenosylhomocysteine sah consequently produces homocysteine would quench fluorescence signal dna templated nanoclusters employed signaling probe study hand adenosine significantly inhibits hydrolysis reaction prevent formation homocysteine consequently highly enhanced fluorescence signal dna ncs retained could used identify presence adenosine employing design principle adenosine sensitively detected high specificity adenosine analogs amp adp atp camp guanosine cytidine urine finally diagnostic capability method successfully verified reliably detecting adenosine present real human serum sample elsevier rights reserved
herein report case year old male shown many psychiatric symptoms whose autopsy disclosed presence dementia lewy bodies dlb years old patient presented stereotyped behavior dietary changes decline social interpersonal conduct clinical settings thought symptoms consistent behavioral variant frontotemporal dementia bvftd lacked core features dlb nevertheless case pathologically defined limbic type dlb died age years looking retrospectively clinical course considered following features suggestive supportive dlb neuroleptic sensitivity autonomic symptoms psychiatric symptoms presumed bvftd like behavioral disturbances caused severe lewy pathology locus ceruleus left anterior temporal region clinical symptoms dlb might multifarious conventionally thought symptoms modified pathological spread dlb within brain important aware possible symptoms dlb overlook diagnosis clinical setting
increasingly live cyber physical spaces spaces physical digital two aspects intertwined cyber physical spaces may exhibit range behaviors smart control heating ventilation light visionary multi functional living spaces spatially organized dynamic way contrast traditional physical environments cyber physical spaces often exhibit dynamic behaviors change time react changes occurring space current design spaces however normally accommodate cyber aspects modern spatial environments capture dynamic behavior spatial design although done cad tools following certain international processes standards building information modelling bim largely produces syntactic descriptions spaces lack dynamic semantics consequence designs automatically formally analyzed respect various requirements emerging dynamic cyber physical spaces safety security reliability requirements typical examples paper show avenue research characterized rethinking design spatial environments dynamic cyber physical spaces software engineering perspective outline approach formally analyzable models may automatically extracted bim depending analysis required checked formally specified requirements regarding static dynamic properties design prior construction phase design time realize automated operational management models also used operation continuously check satisfaction requirements changes occur possibly enforce satisfaction self adaptive strategies run time
introduce graphical syntax signal flow diagrams based language symmetric monoidal categories using universal categorical constructions provide stream semantics sound complete axiomatisation certain class diagrams captures orthodox notion signal flow graph used control theory show diagram syntax realised via rewriting equational theory signal flow graph elsevier inc rights reserved
introduce online anomaly detection algorithm processes data sequential manner time algorithm makes new observation produces decision adaptively updates parameters enhance performance algorithm mainly works unsupervised manner since real life applications labeling data costly even whenever feedback algorithm uses better adaptation algorithm two stages first stage constructs score function similar probability density function model underlying nominal distribution one fit observed data second state score function used evaluate newly observed data provide final decision decision given well known thresholding construct score using highly versatile completely adaptive nested decision tree nested soft decision trees used partition observation space hierarchical manner adaptively optimize every component tree decision regions probabilistic models node well overall structure based sequential performance extensive time adaptation provides strong modeling capabilities however may cause overfitting mitigate overfitting issues first use intermediate nodes tree produce several subtrees constitute models coarser full extend adaptively combine using real life dataset show algorithm significantly outperforms state art
introduce networkit open source software package analyzing structure large complex networks appropriate algorithmic solutions required handle increasingly common large graph data sets containing billions connections describe methodology applied develop scalable solutions network analysis problems including techniques like parallelization heuristics computationally expensive problems efficient data structures modular software architecture goal software package results algorithm engineering efforts put hands domain experts networkit implemented hybrid combining kernels written python frontend enabling integration python ecosystem tested tools data analysis scientific computing package provides wide range functionality including common novel analytics algorithms graph generators via convenient interface experimental comparison related software networkit shows best performance range typical analysis tasks
investigate model two coupled ablowitz ladik lattices admits integrable model reduced symmetric states compute discrete modulational instability gain analytically verified numerically play role coupling parameter epsilon back bone two coupled chain analyzed perform molecular dynamics simulations elucidate short time well long time instability chain demonstrate chain supports formation bright breather coupled wave modes spanning lattice sites either side bond center explore kink solitary profile solutions chains invoking extended tangent hyperbolic function method ethf embedded symbolic computation spectral stability exact solutions determined eigenvalues discrete spectrum demonstrate onset chaos leads quasi periodic dynamics chains period doubling bifurcation route chaos elsevier inc rights reserved
investigate numerically dynamics capillary filling haines jump events using free energy lattice boltzmann simulations processes potentially important multi phase pore scale flow processes geological sequestration oil recovery first focus capillary filling demonstrate numerical method capture correct dynamics limit long times high low viscosity ratios method gives correct scaling length penetrating fluid column function time examining early times capillary filling three consecutive length time regimes observed agreement available experimental work literature addition carry simulations haines jump events idealised realistic rock pore geometries observe haines jump events cooperative non local associated drainage imbibition dynamics observations show pore filling dynamics controlled ohnesorge number associated balance viscous forces inertial surface tension forces using concept able identify type pore filling dynamics occur elsevier ltd rights reserved
investigate effects psychological safety auditor knowledge subordinates willingness share privately known fraud relevant information brainstorming test model illustrating partner leadership affects subordinates perceptions psychological safety affect brainstorming differentially depending level subordinates task knowledge participants watch video simulated brainstorming session manipulate altering partner communicates less condition partner engenders supportive non supportive non threatening threatening group dynamic style encourages discourages idea sharing predict find less knowledgeable auditors increase willingness share privately known fraud relevant information setting less setting effect differential levels knowledgeable auditors changes willingness share information implies criticality encouraging team dynamics engender less knowledgeable subordinates
investigate flow dynamics around rock vane widely used instream structure stream restoration conducting laboratory flume experiments carrying high resolution large eddy simulation les taking advantage parallel computing flume experiments conducted fixed mobile bed conditions velocities bed elevations measured respectively les carried fixed bed experiment directly resolving details rocks constitute vane individual roughness elements channel bed les computed mean flow statistics show good agreement measurements analysis computed flow field reveals existence two counter rotating secondary flow cells downstream vane originate plunging three dimensional streamlines onto lower part sidewall downstream vane examine role secondary flow cells mobile bed condition les results compared equilibrium bed elevation measured mobile bed experiment mobile bed experiment reveals existence oblique sand ridge downstream vane aligned line flow convergence caused collision two secondary flow cells results indicate two counter rotating cells downstream rock vane profound impact mean flow bed shear stress well bed morphodynamics
investigate relation friedmann thermodynamic pressure equations solving friedmann thermodynamic pressure equations simultaneously investigation shows perfect fluid suitable solution friedmann equations leading standard modeling universe expansion history simultaneously satisfy thermodynamic pressure equation friedmann moreover consider various energy definitions komar mass solve friedmann thermodynamic pressure equations simultaneously get models dark energy fluids cosmological consequences obtained solutions also addressed results indicate obtained solutions may unify dominated fluid primary inflationary current accelerating eras one model addition taking account cosmic fluid known equation state eos combining friedmann thermodynamic pressure equations obtain corresponding energy cosmic fluids face limitations finally point cosmological features cosmic fluid also study observational constraints
investigate resonant davey stewartson system resonant system natural dimensional version resonant nonlinear schrodinger equation traveling wave solutions found paper demonstrate effectiveness analytical methods namely improved tan phi expansion method item generalized expansion method seeking exact solutions via resonant davey stewartson system methods direct concise simple implement compared existing methods exact particular solutions containing four types solutions hyperbolic function trigonometric function exponential solutions obtained solutions comparing methods methods results demonstrate aforementioned methods efficient multilinear variable separation method applied tang chaos solitons fractals recently item developed searching exact traveling wave solutions nonlinear partial differential equations abundant exact traveling wave solutions including solitons kink periodic rational solutions found solutions might play important role engineering physics fields shown methods help symbolic computation provide straightforward powerful mathematical tool solving nonlinear problems
investigated evaluation ethicality precedes ethical decision making influenced personal situational factors argued individual contextual factors would simultaneously influence ethicality evaluation found employees regulatory focus significantly influenced evaluation supervisors ethical leadership supervisors employees also found contextual factors interacted individual factors ethicality evaluation process results showed positive relationship employees promotion focus evaluation supervisor ethical leadership negatively moderated supervisor moral attentiveness theoretical practical implications limitations study discussed
investigated well structural features note density relative number changes melodic contour could predict success implicit explicit memory unfamiliar melodies also analyzed features likely elicit increasingly confident judgments old recognition memory task automated analysis program computed structural aspects melodies independent context also reference melodies testset parent corpus pop music features predicted success memory tasks points shared memory component however motivic complexity compared large corpus pop music different effects explicit implicit memory also found features associated different rates old judgments whether items old new rarer motives relative testset predicted hits rarer motives relative corpus predicted false alarms data driven analysis provides support shared separable mechanisms implicit explicit memory retrieval well role distinctiveness true false judgments familiarity
investigated noninvasive procedures hybrid imaging assess sites active inactive hematopoiesis patients primary myelofibrosis pmf end used two radionuclides technetium indium chloride coupled single photon emission tomography computed tomography spect studied five patients pmf one secondary myelofibrosis classical pattern lower fixation tracers axial skeleton myelofibrotic process occurs reactivation sites active hematopoiesis distal skeleton confirmed coupling radionuclides spect imaging allowed precise visualization sites extramedullary hematopoiesis observed spleen liver splenic high uptake coupled spect represents pathognomonic feature pmf conclude hybrid imaging procedures studied might constitute alternative noninvasive method screening whole body marrow way assess impact targeted therapies pmf patients well known distribution hematopoietic active areas disturbed hybrid imaging could also useful diagnostic purposes cases early pmf suspected cases myelofibrosis secondary polycythemia vera essential thrombocythemia
investigated priming analogical problem solutions true false memories children adults asked solve nine verbal proportional analogies three primed deese roediger mcdermott drm lists critical lure problem solution presented initial word list true memory priming three primed drm lists whose critical lures solution verbal proportional analogies false memory priming three unprimed controlled age differences solution rates knowledge base order examine developmental differences speed processing anticipated results showed adults completed problems significantly faster children furthermore children adults solved problems primed false memories significantly faster either primed true memories unprimed problems age groups significant difference solution times unprimed true primed problems findings demonstrate priming problem solutions extends verbal proportional analogies false memories effective priming problem solutions true memories clear positive consequences production false memories elsevier inc rights reserved
investigated contribution monitoring processes emergence false memories children two age groups compared assuming lower monitoring ability preschool age compared older children also manipulated whether elementary school pupils responded memory test without time pressure furthermore frequency list presentation manipulated within participants found presenting lists thrice compared increased number false memories kindergarten children elementary school pupils responding time pressure reduced false memories elementary school pupils responding without time pressure findings indicate kindergarten children still lack ability monitor source activation critical items deese roediger mcdermott lists elsevier inc rights reserved
investigated effects different perspective taking instructions emotional variables context intergroup reconciliation three experiments found individual level group level perspective taking increased willingness compensate outgroup historical transgressions ingroup data suggests two forms perspective taking trigger different psychological processes individual level perspective taking strongly linked feelings empathy group level perspective taking increased feelings collective guilt collective guilt mediated positive effect group level perspective taking willingness compensate effect found individual level perspective taking
investigated efficacy tolerability solifenacin fixed dose children newly diagnosed idiopathic overactive bladder oab total children male female patients aged years mean age range newly diagnosed oab january september prospectively evaluated open label protocol patients treated solifenacin fixed dose daily least weeks efficacy tolerability solifenacin evaluated weeks initiation treatment mean voiding frequency daytime decreased times week treatment mean total oab symptom score oabss decreased week treatment urgency urgency urinary incontinence uui domains significantly improved week treatment complete resolution urgency occurred patients percentage children uui among urgent patients decreased according day voiding diaries average bladder capacity increased drug induced adverse effects aes reported patients results indicate solifenacin fixed dose effective oab symptoms tolerability acceptable without significant aes children oab
investigated relationship among serum insulin level insulin receptor expression renal cell carcinoma rcc outcomes patients rcc underwent nephrectomy also explored role insulin signaling rcc progression murine rcc allograft renca model using metformin treat hyperinsulinemia induced high carbohydrate diet clinically expression level rcc tissue significantly lower patients tumor stage distant metastases expression level rcc tissue significantly lower patients preoperative serum peptide levels greater equal median patients levels less median high expression level significantly associated better disease free overall survival nephrectomy expression level significantly higher murine subcutaneous flank tumors low carbohydrate diet group high carbohydrate diet plus metformin group high carbohydrate diet group vivo progression murine tumors significantly enhanced hyperinsulinemia induced high carbohydrate diet significantly inhibited metformin low high carbohydrate diet groups expression rcc tissue inversely associated cancer progression clinical murine experimental model studies clinical murine allograft model study results suggested hyperinsulinemia promote rcc progression decreased expression high stage rcc tumors poor prognosis may result downregulation induced host hyperinsulinemia
investigated soliton solution coupled nonlinear schrodinger cnls equations equations coupled due cross phase modulation cpm lax pair system obtained via ablowitz kaup newell segur akns scheme corresponding darboux transformation constructed derive soliton solution one two soliton solutions generated using two soliton solutions cnls equation nonlinear tunneling soliton without exponential background discussed finally cascade compression optical soliton multi nonlinear barrier discussed obtained results may promising applications optical devices based optical solitons study soliton propagation birefringence fiber systems optical soliton distributed dispersion nonlinearity management elsevier inc rights reserved
make use kind distributed semi quantum computing models study phase estimation basic idea use distributed micro quantum computers process respectively small quantity quantum states communicate given classical computer via classical channel transport results study phase estimation algorithm basing idea provide distributed semi quantum algorithm phase estimation time complexity first stage worse existing quantum algorithm phase estimation particularly exponential acceleration second stage phase estimation elsevier rights reserved
observed open clusters ngc initial campaign reducing data high precision photometric timeseries challenging due wide point spread function psf blending stellar light dense regions developed image subtraction based reduction pipeline applicable crowded sparse stellar fields applied pipeline data rich super stamp containing two open clusters well neighboring postage stamps paper present image subtraction reduction pipeline demonstrate technique achieves ultra high photometric precision sources super stamp extract raw light curves stars taken ucac epic catalogs trend systematic effects compare photometric results prior reductions published literature trended tfa corrected sources magnitude range achieve best hour window running rms ppm falling ppm fainter stars magnitude range stars trended hour binned light curves achieve highest photometric precision moreover tfa corrected sources higher precision timescales investigated work represents first published image subtraction analysis super stamp method particularly useful analyzing galactic bulge observations carried campaign raw light curves final results trending processes publicly available http hatsurveys org archive
posit commercial based unmanned aerial vehicles uav vulnerable common basic security attacks capable beginner intermediate hackers demonstrating standard ardiscovery connection process access point used parrot bebop uav exploitable uav ability fly disrupted mid flight remote attacker believe vulnerabilities systemic based parrot uavs approach observed normal operation ardiscovery connection process parrot bebop uav used fuzzing technique discover parrot bebop uav vulnerable basic denial service dos buffer overflow attacks ardiscovery connection process exploitation vulnerabilities could result catastrophic immediate disabling uav rotors mid flight also discovered parrot bebop uav vulnerable basic arp address resolution protocol cache poisoning attack disconnect primary mobile device user cases cause uav land return home based literature penetration testing assert based commercial uavs require comprehensive security framework utilizes defense depth approach approach would likely mitigate security risks associated three zero day vulnerabilities described paper well vulnerabilities reported literature framework effective parrot based commercial uavs likely others similar platforms
present challenging new dataset autonomous driving oxford robotcar dataset period may december traversed route central oxford twice week average using oxford robotcar platform autonomous nissan leaf resulted recorded driving almost million images collected cameras mounted vehicle along lidar gps ins ground truth data collected weather conditions including heavy rain night direct sunlight snow road building works period year significantly changed sections route beginning end data collection frequently traversing route period year enable research investigating long term localization mapping autonomous vehicles real world dynamic urban environments full dataset available download http robotcar dataset robots
present data driven method synthesizing indoor scenes inserting objects progressively initial possibly empty scene instead relying hundreds hand crafted scenes take advantage existing large scale annotated rgb datasets particular sun rgb database consisting depth images real scenes form prior knowledge synthesis task object insertion scheme follows occurrence model arrangement model learned sun dataset former elects highly probable combination object categories along number instances per category plausible placement defined latter model compared previous works probabilistic learning object placement make two contributions first learn various classes higher order object object relations including symmetry distinct orientation proximity database relations effectively enable considering objects semantically formed groups rather individuals second algorithm inserts objects one time attains holistic plausibility whole current scene offering controllability progressive synthesis conducted several user studies compare scene synthesis performance results obtained manual synthesis state art object placement schemes variations parameter settings arrangement model
present data parallel algorithm construction delaunay triangulations sphere method combines variant classical bowyer watson point insertion algorithm recently published parallelization technique jacobsen resolves breakdown situation latter approach suitable practical implementation compact formulation complementary aspects discussed parallel workload floating point arithmetics second step generated triangulations reordered stripification algorithm improves cache performance significantly reduces data read operations indirect addressing multi threaded stencil loops paper extended version parallel processing applied mathematics conference contribution copyright john wiley sons ltd
present fast memory efficient algorithm generating compact precomputed voxelized shadows performing much common sub tree merging identical nodes ever created improve construction times several orders magnitude large data structures require much less working memory improve performance suggest two new algorithms remaining common sub trees merged also propose new set rules resolving undefined regions significantly reduces final memory footprint already heavily compressed data structure additionally examine feasibility using cpvs many local lights present two improvements original algorithm allow handle hundreds lights high quality filtered shadows real time frame rates
present hispanic male clinical molecular diagnosis simpson golabi behmel syndrome sgbs patient born multiple anomalies entirely typical sgbs patients including penoscrotal hypospadias large prostatic utricle left coronal craniosynostosis addition demonstrated endocrine anomalies including low random cortisol level suspicious adrenal insufficiency low testosterone level knowledge first report prostatic utricle sgbs second report craniosynostosis unique disease causing mutation likely arose novo mother deletion insertion leads frameshift residue gpc premature stop codon five amino acids residue normally cleaved furin convertase although significance novel mutation respect patient multiple anomalies unknown present case perinatal course patient unique features sgbs confirmed molecular diagnosis wiley periodicals inc
present method structural fluid mechanics computations ram air parachutes ram air parachute parafoil inflated airflow inlets leading edge better control gliding capability round parachutes reliable analysis ram air parachutes requires accurate representation parafoil geometry fabric porosity complex multiscale flow behavior involved class problems key components method space time variational multiscale vms method version slip interface method thin porous structure fluid two sides iii isogeometric analysis iga special purpose nurbs mesh generation techniques parachute structure flow field inside outside parafoil vms method stabilized formulation also serves turbulence model deal effectively complex multiscale flow behavior stsi version porosity modeling deal fabric porosity fashion consistent deal standard sis enforce dirichlet boundary conditions weakly iga nurbs basis functions space gives relatively number unknowns accurate representation parafoil geometry increased accuracy flow solution special purpose mesh generation techniques enable nurbs representation structure fluid domains significant geometric complexity test computations present building starting parachute shape starting flow field associated parachute shape first two key steps fluid structure interaction analysis computations demonstrate effectiveness method class problems elsevier ltd rights reserved
present method recognizing object multi mode fiber number speckle patterns transmitted multi mode fiber provided classifier based machine learning experimentally demonstrated binary classification face non face targets based method measurement process experimental setup random nonlinear multi mode fiber typical strongly scattering medium reference light used setup comparisons three supervised learning methods support vector machine adaptive boosting neural network also provided learning methods achieved high accuracy rates classification approach presented realize compact smart optical sensor practically useful medical applications endoscopy also study indicated promising utilization artificial intelligence rapidly progressed reducing optical computational costs optical sensing systems
present new efficient algorithm finding point sources photon event data stream fermi gamma ray space telescope fermifast key advantage fermifast constructs catalogue potential sources fast arranging photon data hierarchical data structure using structure fermifast rapidly finds photons could originated potential gamma ray source calculates likelihood ratio contribution potential source using angular distribution photons within region interest find within minutes significant half fermi third point source catalogue fgl nearly per cent purity data used construct catalogue higher purity sample desirable one achieve sample includes significant third fermi fgl per cent sources unassociated fermi sources outside galactic plane eight fermifast detections associated fgl sources eight six yield significant detections greater sigma binned likelihood analysis performed software allows rapid exploration fermi data simulation source detection calculate selection function various sources errors obtained parameters sources detected
present new approach compute mass matrix solid finite elements allows significant reduction number integration points method based exploiting information regarding mathematical form integrand enables higher degree precision number integration points compared standard quadrature use approach general applied consistent lumped matrices element types focus consistent mass matrix widely used node tetrahedral element demonstrate superiority new approach conventional quadrature use example show new integration scheme enables degree precision integration point compared points conventional numerical integration also points integration rule practically equivalent conventional numerical integration points elsevier rights reserved
present new approach estimate dynamic stiffnesses soil foundation systems using earthquake induced response signals recorded multi story buildings sparsely instrumentation identification soil foundation dynamic stiffness parameters real life data especially earthquake induced response signals arguably one challenging problems structural geotechnical earthquake engineering said parameters frequency dependent non stationary input excitation measurable due soil structure interaction effects possible identify parameters using recently developed blind source separation techniques provided finite element model superstructure available however developing updating finite element model usually laborious undertaking success strongly depends spatial density measurements present study offer new method based use timoshenko beam model represent superstructure method key parameters timoshenko beam model soil foundation system adjusted systematic procedure systems overall flexible based modal properties match identified real life data proposed method robust sensor sparseness yields accurate results even foundation rocking measured proposed procedure first verified using synthetic problem subsequently applied real life data recorded millikan library building located caltech campus pasadena california
present new approach lightweight intelligent transportation systems approach rely traditional expensive infrastructures rather advanced machine learning algorithms takes images traffic cameras limited number locations estimates traffic entire road network approach features two main algorithms first probabilistic vehicle counting algorithm fromlow quality images falls category unsupervised learning network inference algorithm based inverse markov chain formulation infers traffic arbitrary links limited number observations evaluated approach two different traffic data sets one acquired nairobi kenya kyoto japan
present new mathematical theory explaining fluid mechanics subsonic flight fundamentally different existing boundary layer circulation theory prandtl kutta zhukovsky formed year ago new theory based new resolution alembert paradox showing slightly viscous bluff body flow viewed zero drag lift potential flow modified rotational slip separation arising specific separation instability potential flow turbulent flow nonzero drag lift wing separation mechanism maintains large lift potential flow generated leading edge price small drag resulting lift drag quotient size small propeller plane cruising speed reynolds number approximate jumbojet take landing approximate allows flight affordable power new mathematical theory supported computed turbulent solutions navier stokes equations slip boundary condition model observed small skin friction turbulent boundary layer always arising close accordance experimental observations entire range angle attacks including stall using millions mesh points full wing body configuration
present new version core structural package application programming interface apinetworks treatment complex networks arbitrary computational environments new version written java presents several advantages previous version portability java code easiness object oriented design implementations simplicity memory management addition additional data structures introduced storing sets nodes edges also resorting different garbage collectors currently available jvm java version much efficient one respect memory management particular collector efficient one parallel execution java application using apinetworks java outperforms version well known networkx jgrapht packages building bfs traversal linear complete networks better memory management present version allows modeling much larger networks
present non invasive ambient intelligence framework semi automatic analysis non verbal communication applied restorative justice field propose use computer vision social signal processing technologies real scenarios victim offender mediations applying feature extraction techniques multi modal audio rgb depth data compute set behavioral indicators define communicative cues fields psychology observational methodology test methodology data captured real victim offender mediation sessions catalonia define ground truth based expert opinions annotating observed social responses using different state art binary classification approaches system achieves recognition accuracies predicting satisfaction predicting agreement receptivity applying regression strategy obtain mean deviation predictions range computed social signals elsevier rights reserved
present novel formulation employs task specific muscle synergies state space representation neural signals tackle challenging myoelectric control problem lower arm prostheses proposed framework incorporates information muscle configurations muscles acting synergistically agonist antagonist pairs using hypothesis muscle synergies synergy activation coefficients modeled latent system state estimated using constrained kalman filter task dependent synergy activation coefficients estimated real time electromyogram emg data used discriminate various tasks task discrimination helped post processing algorithm uses posterior probabilities proposed algorithm robust well computationally efficient yielding decision discrimination accuracy approximately real time performance controllability algorithm evaluated using targeted achievement control tac test proposed algorithm outperformed common machine learning algorithms single well multi degree freedom dof tasks line discrimination accuracy real time controllability
present novel numerical method simulate crack growth directly computer aided design cad geometry component without mesh generation method isogeometric boundary element method igabem based non uniform rational splines nurbs nurbs basis functions used domain crack representation well approximate physical quantities involved simulations stable quadrature scheme singular integration proposed enhance robustness method dealing highly distorted elements convergence studies crack opening displacement performed penny shaped crack elliptical crack two approaches extract stress intensity factors sifs contour integral virtual crack closure integral compared using dual integral equations results show remarkable accuracy computed sifs leading smooth crack paths reliable fatigue lives without requiring generation mesh cad model component consideration elsevier rights reserved
present novel parallel address lookup architecture based graphics processing unit gpu via compute unified device architecture cuda architecture consists two functions host function device function host function executed cpu construct update data structure address lookup executed device function gpu host device functions executed simultaneously fully utilize computational resources shorten lookup time trie based data structure optimized cuda developed trie based data structure uses multi bit stride shorten trie depth also improves efficiency texture cache gpus experimental results show low end gpu achieve throughput billion packets per second ipv routing tables prefixes high end gpu double performance employing dual data structures implementation support several hundred thousand updates per second
present numerical method evolves two temperature magnetized radiative accretion flow around black hole within framework general relativistic radiation magnetohydrodynamics implemented code koral gas consists two sub components ions electrons share dynamics experience independent relativistically consistent thermodynamical evolution electrons ions heated independently according prescription literature magnetohydrodynamical turbulent dissipation energy exchange particle species via coulomb collisions included addition electrons gain lose energy momentum absorbing emitting synchrotron bremsstrahlung radiation compton scattering evolution equations handled within fully covariant framework relativistic fixed metric space time black hole numerical results presented five models low luminosity black hole accretion case model mass accretion rate similar edd find radiation negligible effect either dynamics thermodynamics accreting gas contrast model larger similar edd behaves differently accreting gas much cooler flow geometrically less thick though quite thin accretion disc
present performance comparison bounding volume hierarchies trees ray tracing many core architectures gpus comparison focused rendering times traversal characteristics gpu using data structures optimized high performance tracing rays achieve low rendering times extensively examine constants used termination criteria two data structures show contemporary gpu architecture nvidia kepler bounding volume hierarchies higher ray tracing performance trees simple moderately complex scenes hand trees higher performance complex scenes particular high depth complexity finally analyse causes performance discrepancies using profiling characteristics ray tracing kernels
present preliminary examination new approach long standing problem non newtonian fluid mechanics first summarize general implicit functional relation stress rate strain continuum memory reduced well known linear differential constitutive relations account relaxation retardation show relaxation retardation asymptotically equivalent small deborah numbers whence causal pure relaxation models necessarily correspond ill posed pure retardation models suggest dichotomy could possible way reconcile discrepancy theory certain experiments viscoelastic liquids conjectured exhibit stress retardation elsevier ltd rights reserved
present python program freq calculating optimal scale factors calculating harmonic vibrational frequencies fundamental vibrational frequencies zero point vibrational energies electronic structure calculations program utilizes previously published scale factor optimization model alecu efficiently obtain three scale factors set computed vibrational harmonic frequencies order obtain three scale factors user needs provide zero point energies selected molecules user access gaussian gaussian program provide option user run program entering keywords certain method basis set gaussian gaussian program four python programs input input pbs pbs also provided generating gaussian gaussian input pbs files program also used data electronic structure package manual use program included code package program summary program title freq catalogue identifier afbh program summary url http cpc qub summaries afbh html program obtainable cpc program library queen university belfast ireland http www cpc qub truhlar group software page comp chem umn edu freq licensing provisions gnu gpl lines distributed program including test data etc bytes distributed program including test data etc distribution format tar programming language python computer computer python compiler operating systems linux unix classifications external routines gaussian gaussian see restrictions nature problem optimization property specific scale factors vibrational frequencies specific electronic model chemistry solution method method based minimizing root mean square deviation set zero point energies derived harmonic vibrational frequencies either provided user computed fly experimentally determined counterparts restrictions order compute electronic model chemistry harmonic zero point energies fly user must access gaussian gaussian program electronic model chemistry zero point energies read program required additional comments opening freq tar file user find run file used run programs obtain scaling factors user chosen electronic structure model chemistry running time less second user provides zero point energies zero point energies computed running time depends electronic model chemistry used compute well efficiency gaussian program test obtain results within min using one node eight processors gaussian input minnesota supercomputing institute meabi supercomputer published elsevier
present radar sensor designed detect image moving objects targets side wall radar sensor composed linear array vivaldi antenna elements radio frequency switch microcontroller unit transceiver linear array total eight antenna elements used sensors synthetic aperture radar sar configuration cross range axis improve resolution dimension design steps vivaldi antenna elements entire linear array presented design prototyping procedure details radar sensor given wall radar twr imaging experiments performed stationary moving targets using assembled sensor resultant twr images experiments presented image formation back projection type image focusing algorithm implemented applied increase signal noise ratio raw images constructed radar images demonstrated radar sensor could successfully detect image stationary moving targets side wall society photo optical instrumentation engineers spie
present review recent techniques performing geometric analysis cultural heritage applications survey aimed researchers areas computer graphics computer vision computing well scholars practitioners field problems considered include shape perception enhancement restoration preservation support monitoring time object interpretation collection analysis problems typically rely understanding structure shapes question local global level survey discuss different problem forms review main solution methods aided classification criteria based geometric scale analysis performed cardinality relationships among object parts exploited analysis finalize report discussing open problems future perspectives
present symbolic numeric hybrid method based sum squares sos relaxation rational vector recovery compute inequality invariants ranking functions proving total correctness generating preconditions programs sos relaxation method used compute approximate invariants approximate ranking functions floating point coefficients gauss newton refinement rational vector recovery applied approximate polynomials obtain candidate polynomials rational coefficients exactly satisfy conditions invariants ranking functions end several examples given show effectiveness method
present theory thermal grooving surface motion due surface diffusion based solely geometrical energetic arguments variational approach involving thermodynamic extremal principle theory derived fully three dimensional setting interface contact conditions junction lines points material aggregate derived rigorously without ambiguity finite element implementation model employed numerical examples presented compared experimental results literature acta materialia inc published elsevier ltd rights reserved
present viewpoint showing analog signal processing approaches becoming configurable programmable like digital counterparts retaining huge computational efficiency given power budget compared digital counterparts present recent results programmable configurable analog signal processing describing widespread potential approaches discuss issues configurable systems including size power computational tradeoffs well address computational efficiency approaches analog circuits systems research education significantly benefit computational flexibility provided large scale fpaas component density devices sufficient synthesize large systems short period time however level reconfigurable programmable complexity requires development platform cad tools demonstrate capabilities large scale fpaas widely accepted address need self contained fpaa setup developed along integrated software design flow ethernet connection power outlet researcher student explore numerous analog circuit possibilities provided large scale fpaas elsevier inc rights reserved
present adaptive biofeedback game teaching self regulation stress approach consists monitoring user physiology gameplay adapting game using positive feedback loop rewards relaxing behaviors penalizes states high arousal evaluate approach using casual game three biofeedback modalities electrodermal activity heart rate variability breathing rate three biosignals measured noninvasively wearable sensors represent different degrees voluntary control selectivity toward arousal conducted experiment trial participants compare three modalities standard treatment deep breathing control condition game without biofeedback results indicate breathing based game biofeedback effective inducing relaxation treatment four groups participants group also showed greater retention relaxation skills without biofeedback subsequent stressor
present optimal efficient algorithm finding shortest path elastic optical network algorithm adaptation dijkstra shortest path algorithm take account spectrum continuity contiguity constraints limit path length adaptation redefines node label dijkstra algorithm allows revisiting nodes even higher cost different slices avoids loops prunes worse labels algorithm generic agnostic specific spectrum allocation policy finds largest set available slices slices allocated way describe motivate algorithm design point freely available implementation using boost graph library carried simulation runs large random realistic networks found probability establishing connection using proposed algorithm even twice large probability establishing connection using edge disjoint shortest paths yen shortest paths
present efficient locking mechanisms hierarchical data structures several applications work abstract hierarchy objects parallel execution hierarchy necessitates synchronization across workers operating different parts hierarchy existing synchronization mechanisms either coarse inefficient hoc resulting reduced unpredictable amount concurrency propose new locking approach based structural properties underlying hierarchy show developed techniques efficient even hierarchy arbitrary graph applicable even hierarchy involves mutation theoretically present approach locking cost minimizing instance generic algebraic model synchronization hierarchical data structures using stmbench illustrate considerable reduction locking cost resulting average throughput improvement
present vision individualized knowledge graphs ikgs cardiovascular medicine modern informatics platform exchange inquiry comprehensively integrates biological knowledge medical histories health outcomes individual patients envision could transform clinicians scientists together discover communicate apply new knowledge
present paper library calculates analytic decomposition yukawa interactions invariant terms basis make use oscillator expansion formalism spinor representations expressed terms creation annihilation operators grassmann algebra acting vacuum state noncommutative operators products simulated sospin implementation doubly linked list data structures data structures determinant achieve higher performance simplification large products creation annihilation operators illustrate use library complete examples decompose yukawa terms invariant terms degrees freedom demonstrate example higher dimensional field operator terms also processed library finally describe functions available made simplify writing spinors interactions specifically models program summary program title sospin catalogue identifier aezm program summary url http cpc qub summaries aezm html program obtainable cpc program library queen university belfast ireland licensing provisions gnu general public license version lines distributed program including test data etc bytes distributed program including test data etc distribution format tar programming language computer apple operating system unix linux mac ram depending number processes required classification external routines order make simplifications expressions obtained library calls symbolic manipulation system form program nature problem decomposition yukawa interaction invariant terms fields solution method make use oscillator expansion formalism spinor representations expressed terms creation annihilation operators grassmann algebra acting vacuum state running time depends input expressions take seconds large representations memory exhaustion elsevier rights reserved
present one first quantitative studies auditory verbal experiences hearing voices auditory verbal agency inner speech specifically talking imaginary voices characters healthy participants across states consciousness tools quantitative linguistic analysis used measure participants implicit knowledge auditory verbal experiences auditory verbal agencies displayed mentation reports four different states analysis conducted total mentation reports rapid eye movement rem sleep non rem sleep sleep onset waking physiology controlled nightcap sleep wake mentation monitoring system sleep onset hallucinations traditionally focus scientific attention auditory verbal hallucinations showed lowest degree whereas rem sleep showed highest degrees degrees different linguistic pragmatic aspects likewise depend physiological states quantity pragmatics function physiologically distinct state consciousness conceived
present framework verification parameterized infinite state systems framework successfully applied verification heterogeneous systems ranging distributed fault tolerant protocols programs handling unbounded data structures application domains able infer quantified invariants mandatory requirement successful results framework differentiates state art solutions targeting generation quantified safe inductive invariants instead monolitically exploiting single static analysis technique based effective integration several analysis strategies paper targets description engineering strategies adopted successful implementation integrated framework presents extensive experimental evaluation demonstrating effectiveness
present case year old woman past history repeated miscarriage budd chiari syndrome secondary primary myelofibrosis treatment oral anticoagulant agents patient admitted hospital presented gastrointestinal bleeding melena asthenia progressive anemia initial upper endoscopy extrinsic duodenal compression associated ulcer posterior face first portion duodenum upper duodenal knee observed following days huge spontaneous retroperitoneal hematoma due anticoagulation diagnosed computed tomography treated percutaneous drainage withdrawal antithrombotic drugs evolution patient initially satisfactory suffered subclavian jugular vein thrombosis reintroduction anticoagulant agents lowest therapeutic doses required
present case year old man myelofibrosis associated pulmonary arterial hypertension pah underwent allogeneic hematopoietic stem cell transplantation subsequent resolution disease pah right heart catheterization used guide pah therapy transplantation drug interactions adverse effects renal insufficiency posed clinical challenges management pah specific medications transplantation pah improved soon transplantation vasoactive medications tapered resolution pah confirmed repeat measurement pulmonary hemodynamic characteristics although etiology pathophysiology resolution pah unclear myelopulmonary pathophysiologic link likely contributed first report describing resolution myelofibrosis associated pah allogeneic hematopoietic stem cell transplantation
present construction maxwell equal area law guass bonnet ads black holes third order lovelock ads black holes equal area law used find number location points intersection plots gibbs free energy get thermodynamically preferred solution corresponds first order phase transition obtain radius small large black holes phase transition share gibbs free energy case two critical points explored much details latent heat also studied
present development framework distributed control systems scripting frontend monitoring facilities recently upgraded hobby eberly telescope het common flexible control data acquisition layer message passing implemented top zeromq wraps final designs new hardware component including tracking metrology instrumentation calibration equipment homogeneous command response event layer normalizes diversity lower level software interfaces easing development telescope control system tcs applications developed framework easily interface new tracker legacy instrumentation primary mirror weather dome tracker support structure framework facilitates testing vetting characterization telescope tcs examples real time monitoring capabilities python scripting methods various telescope components yield insight overall system performance lessons learned along way future refinements anticipated enhancements detailed
present two lines asics dedicated control readout ccd sensors cabac clocks biases asic ccds provides required bias voltages clocks aspic analog signal processing integrated circuit processes ccd output channels amplification correlated double sampling conversion differential signal chips highly configurable order fulfill wide range astronomical ccd readout needs fast readout wide field imaging arrays slower speeds higher gains spectroscopy sizes temperature ranges allow integrate cryostat close sensors offer diagnostic capabilities assist integration addition extensive stand alone tests chips integrated lsst reb raft electronics board tested driving prototype ccd lsst focal plane
previously showed microglial keratan sulfate induced amyotrophic lateral sclerosis however functional roles glycan synthetic enzyme neurodegenerative diseases alzheimer disease progressive disorder unclear study modified sialic acids molecular mass kda carbohydrate sulfotransferase glcnacst regulated brains two transgenic mouse models brains patients glcnacst deficient glcnacst mice demonstrated complete absence microglial sialylated glcnacst primary microglia showed increased level amyloid beta phagocytosis hyperresponsive interleukin potent antiinflammatory cytokine moreover glcnacst mice manifested reduced cerebral amyloid beta deposition glcnacst synthesizing sialylated thus modulates pathology inhibition synthesis targeting glcnacst may therefore beneficial controlling pathogenesis
propose bayesian combination approach multivariate predictive densities relies upon distributional state space representation combination weights several specifications multivariate time varying weights introduced particular focus weight dynamics driven past performance predictive densities use learning mechanisms proposed approach model set incomplete meaning models individually misspecified sequential monte carlo method proposed approximate filtering predictive densities combination approach assessed using statistical utility based performance measures evaluating density forecasts simulated data macroeconomic time series surveys stock market prices simulation results indicate set linear autoregressive models combination strategy successful selecting probability close one true model model set complete able detect parameter instability model set includes true model generated subsamples data also substantial uncertainty appears weights predictors similar residual uncertainty reduces model set complete learning reduces uncertainty macro series find incompleteness models relatively large beginning recent financial crisis lower great moderation predicted probabilities recession accurately compare nber business cycle dating model weights substantial uncertainty attached respect returns series find investment strategy using combination predictions professional forecasters white noise model puts weight white noise model beginning switches giving weight professional forecasts time information complete predictive distribution moments turns important turbulent times recent financial crisis generally proposed distributional state space representation offers great flexibility combining densities elsevier rights reserved
propose computational framework simulation deformation fracture shells well suited situations widespread damage fragmentation due impulsive loading shell modeled shear flexible theory discretized discontinuous galerkin finite element method fracture represented cohesive zone model element edges key feature method underlying shear flexible shell theory enables description transverse shear fracture modes addition plane bending modes accessible kirchhoff love thin shell formulations especially important impulsive loading conditions shear failure near stiffeners supports common discontinuous galerkin formulation inherits scalability properties demonstrated previously large scale simulation fracture solids avoiding artificial elastic compliance issues common cohesive model approaches demonstrate ability framework capture transverse shear fracture mode numerical examples parallel computation capabilities method simulation explosive decompression skin full scale passenger aircraft fuselage published elsevier
propose computational model shape illumination albedo inference pulsed time flight tof camera contrast tof cameras based phase modulation camera enables general exposure profiles results added flexibility requires novel computational approaches address challenge propose generative probabilistic model accurately relates latent imaging conditions observed camera responses principled realtime inference model turns infeasible propose employ efficient non parametric regression trees approximate model outputs result able provide pixel video frame rate estimates uncertainty depth effective albedo ambient light intensity results present state art depth imaging flexibility approach allows easily enrich generative model demonstrate extending original single path model two path model capable describing multipath effects new model seamlessly integrated system additional computational cost work also addresses important question optimal exposure design pulsed tof systems finally benchmark purposes obtain realistic empirical priors multipath insights phenomena propose physically accurate simulation multipath phenomena
propose computationally efficient fully polynomial time approximation scheme fptas compute approximation arbitrary precision value function convex stochastic dynamic programs using technique approximation sets functions introduced halman math oper res paper deals convex case following contributions first improve worst case running time given halman second design implement fptas excellent computational performance show faster exact algorithm even small problem instances small approximation factors becoming orders magnitude faster problem size increases third show careful algorithm design errors introduced floating point computations bounded provide guarantee approximation factor exact infinite precision solution provide extensive computational evaluation based randomly generated problem instances coming applications supply chain management finance running time fptas theoretically experimentally linear size uncertainty set
propose fuzzy ontology human activity representation allows model reason vague incomplete uncertain knowledge relevant subdomains found missing previous proposed ontologies domain modelled well resulting fuzzy owl ontology able model uncertain knowledge represent temporal relationships activities using underlying fuzzy state machine representation provide proof concept approach work scenarios office domain also make experiments emphasize benefits approach respect crisp ontologies result demonstrate inclusion fuzzy concepts relations ontology provide benefits recognition process respect crisp approaches elsevier rights reserved
propose new multi physics multi scale integrated computational materials engineering framework predictive geodynamic simulations first multiscale application presented allows linking existing advanced material characterization methods nanoscale laboratory field geodynamic scales new rock simulation framework outcome example simulation diachronous australian intraplate orogenic events found caused one process non linear progression fundamental buckling instability australian intraplate lithosphere subject long term compressive forces identify four major stages instability long wavelength elasto visco plastic flexure lithosphere without localized failure first myrs loading incipient thrust central hinge model myrs followed secondary tertiary thrust myrs away either side central thrust progression subsidiary thrusts advancing towards central thrust myrs model corroborated multiscale observations nano micro analysis deformed samples central thrust giving evidence cavitation creep fractures thrust size veins melts pseudotachylite evidence intermittent shear heating events thrust width thrust known mylonitic redbank shear zone corresponding width steady state solution shear heating thrust exactly balances heat diffusion
propose new sharing analysis object oriented programs based abstract interpretation two variables share bound data structures overlap show sharing analysis greatly benefit linearity analysis propose combined domain including aliasing linearity sharing information use graph based representation aliasing information naturally encodes sharing linearity information define necessary operators analysis java like language
propose novel method conceptualized properties physics particular shape flame determined temperature enables control mechanism intuitive shaping flame focused trade issue computer graphics whereby turbulent flow expresses characteristics flame tendency shift continuously whereas velocity constraints contain fluid within target shape tendency force movement particular direction trade made difficult animation designers maintain flame within intended target shape paper resolves issue enabling flame controlled without velocity constraints using following two techniques first model temperature force explosion generated combustion explosive gaseous fuel apply certain regions second expand space interface fuel burned products classifying space four regions controlling target shape flame delicate adjustments temperature region experiments show flame maintains appearance dynamic movement preserving detailed shapes specified scene designers
propose simulation based analog equivalence boundary search methodology high level simulink models low level hspice counterparts equivalence high low level designs determined comparing set predefined performance parameters measured simulation models methodology investigates search space obtain boundary input parameters models equivalent performance parameters build optimization problem error percentage performance parameters models less specified threshold defined success criteria problem input parameters determined utilizing evolutionary computation end optimization border equivalence models found input parameters satisfying success criteria demonstrate validity approach three designs inverter operational amplifier buck converter approach proves efficient tool finding equivalence boundary analog circuits models elsevier rights reserved
propose spectral turning bands approach simulation second order stationary vector gaussian random fields approach improves existing spectral methods coupling importance sampling techniques notable insight one simulate vector random field whose direct cross covariance functions continuous absolutely integrable provided one knows analytical expression spectral densities without need spectral densities bounded support simulation algorithm computationally faster circulant embedding techniques lends parallel computing low memory storage requirement numerical examples varied spatial correlation structures presented demonstrate accuracy versatility proposal
propose three state frailty markov model coupled likelihood based inference analyse tooth level life course data caries research analysis challenging intraoral clustering interval censoring multiplicity caries states computational complexities also develop bayesian approach predict future caries transition probabilities given observed life history data numerical experiments demonstrate methods proposed perform well finite samples moderate sizes practical utility model illustrated using life course data unique longitudinal study dental caries young low income urban african american children analysis evaluate spatial symmetry mouth respect life course dental caries whether type tooth similar decay process boys girls
propose architecture self motivated agents allowing construct knowledge objects geometrical properties space interaction environment self motivation defined tendency experiment respond behavioral opportunities afforded environment interactions predefined valences specify inborn behavioral preferences long term goal design agents construct knowledge environment experience rather exploiting pre coded knowledge time agent learns relations elements environment afford interactions perception elements form data structures called signatures interactions signatures allow agent attribute low level semantics elements constitute environment based valences interactions without predefined knowledge elements regardless number element types signatures interaction used localize elements space construct data structures characterize spatial properties space called signatures places signatures presence signatures place presence characterize space using interactions rather geometrical topological properties agent uses structures maintain egocentric representation affordances surrounding environment without preconception elements compose environment without using notions geometrical space experiments simulated agents show learn behave environment taking account multiple surrounding objects reaching avoiding objects according valence interactions afford elsevier rights reserved
propose efficient entanglement concentration protocol ecp nonlocal three atom systems arbitrary unknown less entangled state resorting faraday rotation photonic polarization cavity quantum electrodynamics systematic concentration method first step present ecp one party quantum communication performs parity check measurement two atoms two three atom systems dividing composite six atom systems two groups first group three parties obtain three atom systems less entangled state two unknown coefficients second group obtain less entangled two atom systems second step ecp three parties obtain subset three atom systems standard maximally entangled state exploiting three atom two atom systems moreover preserved systems failed instances used resource entanglement concentration next round total success probability ecp therefore largely increased iterating entanglement concentration process several rounds distinct feature ecp concentrate arbitrary unknown atomic entangled states via photonic faraday rotation thus may universal useful entanglement concentration future quantum communication network
propose combining shape changing interfaces spatial augmented reality extending space appearances interactions actuated interfaces shape changing interfaces dynamically alter physical appearance objects integration spatial augmented reality additionally allows dynamically changing objects optical appearance high detail way devices render currently challenging features high frequency texture fast motion frame combination context computer graphics analogies established techniques increasing realism objects bump mapping extensible framework helps identify challenges two techniques benefits combination utilize prototype shape changing device enriched spatial augmented reality projection mapping demonstrate concept present novel mechanical distance fields algorithm real time fitting mechanically constrained shape changing devices arbitrary graphics furthermore present technique increasing effective screen real estate spatial augmented reality view dependent shape change
propose herein new portfolio selection method switches two distinct asset allocation strategies important component carefully designed adaptive switching rule based machine learning algorithm shown using adaptive switching strategy combined wealth new approach weighted average successive constant rebalanced portfolio portfolio particular asymptotically superior portfolio mild conditions long run applications real data show returns sharpe ratios proposed binary switch portfolio best among several popular competing methods varying time horizons stock pools
propose religion impacts trust trustworthiness ways depend individuals socially identified connected religiosity religious affiliation may serve markers statistical discrimination affiliation religion may enhance group identity affiliation irrespective creed may lend social identity turn induce taste based discrimination religiosity may also relate general prejudice test hypotheses across three culturally diverse countries participants willingness discriminate beliefs trustworthy trusting others well actual trust trustworthiness measured incentive compatibly find interpersonal similarity religiosity affiliation promote trust beliefs reciprocity religious participants also believe belonging faith trustworthier invest trust religion religiosity amplifies effect across non religious categories whereas religious participants willing discriminate less religious participants likely display group biases authors published elsevier
proposed equation formulating relationship resonant frequency quartz crystal mass loading equation developed sauerbrey concerning quartz crystal microbalance qcm improved new approach based mechanical strength materials equation seemingly trivial greatly improves accuracy respect frequency mass relationship frequency shifts case selected materials methods treat effects crystal mounting non uniformity deposited films elucidated
provide brief response commentary submitted rosky questions rationale methodological merits original study full disclosure polygraph outcome differences juvenile adult sex offenders heart rosky substantive concerns premise research tying polygraphy outcomes actual recidivism useful worthwhile also questions overall utility validity polygraphy acknowledge challenge two points furthermore many methodological concerns expressed rosky represent either misunderstanding research question study design sample disregard explicit declarations made respect study limitations overall appears rosky accused answering well question trying ask response addresses key substantive methodological concerns extended rosky clarifies actual aims scope original study also argue calm rational scientific discussion best approach understanding improve clinical methods used sex offender treatment
report year onset age man diagnosed rapidly progressing early onset alzheimer disease predominant extrapyramidal symptoms initial presenting symptoms mutation presenilin gene psen founded unaffected parents proband carriers mutation histories extrapyramidal diseases suggesting novo origin mutation valgly variation widens number psen mutations responsible early onset alzheimer disease extrapyramidal phenotype would help establish functional map presenilin protein architecture elsevier inc rights reserved
report case acute onset multifocal vertebral osteitis marked impact patient general health radiological scintigraphic magnetic resonance findings made necessary carry differential diagnosis distinguish infiltrative neoplastic process determine whether infectious inflammatory etiology presence noninfectious multifocal osteitis sternoclavicular arthritis subsequent development plantar pustulosis pointed sapho syndrome treatment infliximab led improvement clinical symptoms laboratory values radiological abnormalities elsevier espana sociedad espafiola reumatologia colegio mexicano reumatologia rights reserved
report pulse width modulation pwm buck converter able achieve power conversion efficiency pce light loads efficiency wide range load conditions generating output supply converter occupies cmos processes requires two external components capacitor inductor
report case year old man achieved remarkable improvement characteristic non alcoholic steatohepatitis dieting initially body mass index proactively commenced low calorie diet body mass index decreased years period carried liver biopsy four times liver fibrosis well inflammation steatosis ballooning improved non alcoholic fatty liver disease activity score decreased fat deposits liver tissue changed macrovesicular droplets microvesicular finally disappeared along improved histology alanine aminotransferase homeostasis model assessment insulin resistance ferritin leptin high sensitivity reactive protein cytokeratin decreased adiponectin increased linearly however clear changes observed markers wisteria floribunda agglutinin positive mac binding protein wfa mbp typeiv collagen procollageiii peptide fibrosis index along dieting first study report gradual improvement liver histology four liver biopsies fibrosis markers patient non alcoholic steatohepatitis achieved complete recovery solely dieting
report case year old female patient hypothyroidism underwent bariatric surgery developed severe hypothyroidism despite high doses oral levothyroxine tablets initially high dose tablets absorption test performed exclude pseudo malabsorption view modest increase serum levels liquid formulation absorption test performed showed faster efficient absorption thyroid hormones discuss issue distinguishing malabsorption pseudo malabsorption review literature concerning benefits liquid cases impaired absorption bariatric surgery consider socio economic implications different liquid formulations
report computer aided design results gasb inas broken gap gate around nanowire tunneling fet tfet designing semi empirical tight binding method using spds used band structure model produce bulk properties calculated band structure cooperated open boundary conditions obcs three dimensional schrodinger poisson solver execute quantum transport simulators find device configuration operation voltage exhibit desired low sub threshold swing broken gap tfets normally
report realization new version fiber optic gyroscope fog using low cost multimode fiber components achieved optimal choice components fiber coupler light source photodetector aim behind work demonstrate versatility low cost multimode fog rate grade performance applications analog signal processing open loop operation used proposed fog experiment obtained sensitivity similar degrees angle random walk degrees root influence coupler technology performances investigated elsevier inc rights reserved
report two newborns female external genitalia bilateral inguinal swelling diagnosed beta hydroxysteroid dehydrogenase type deficiency rare cause disorder sexual development first case normal clitoral size vaginal urethral openings palpable gonads inguinal region low testosterone low levels basal gnrh stimulated gonadotropin second case similar external genitalia low testosterone borderline basal normal stimulated gonadotropin levels low testosterone androstenedione ratios respectively normal human chorionic gonadotropin stimulation indicated beta hydroxysteroid dehydrogenase type deficiency hsdb sequencing revealed homozygous novel mutation exon first case homozygous exon second
retrieve vertical meridional variations methane mole fraction titan lower troposphere analyzing near infrared ground based observations july adamkovics generate synthetic spectra using atmospheric methane profiles contain supersaturation discontinuities fit observations thereby retrieve minimum saturation altitudes corresponding specific humidities boundary layer relate turn surface level relative humidities using independent surface temperature measurements also compare results general circulation model simulations interpret constrain relationship humidities surface liquids results show titan lower troposphere undersaturated latitudes south degrees consistent dry surface increases humidity toward north pole indicate appreciable surface liquid coverage observations consistent considerably liquid methane existing north pole present observed lakes degeneracy low level methane haze leads substantial uncertainty determining extent source region elsevier inc rights reserved
retrospectively analyzed outcomes patients primary myelofibrosis treated splenic irradiation symptomatic splenomegaly january december hospitals median age time years range median dose radiation per course administered median eight fractions spleen size reduced patients persisted median months range symptom relief occurred patients lasted median months range although provided high rate palliation patients symptomatic splenomegaly responses transient significant thrombopenia occurred eight patients neutropenia observed seven nine patients required increased number red blood cell transfusions five patients developed serious infections two deaths result induced cytopenia median survival patients months range dynamic international prognostic scoring system model effectively distinguished prognosis patients intermediate high risk groups
review developments field phototherapy terms treatment wavelength dosimetry phosphor used different dermatoses attempt categorize skin lesions diseases morphology focusing conditions treated using phototherapy photochemotherapy recent research review articles studied treatments explained information phototherapy applicable psoriasis diseases tabulated clinical features epidemiology epitalogy various types psoriasis together therapies available treat reported needs based research carried narrow broad band uvb wavelength emitting phosphors psoralen combined uva puva depending upon disease undergoing treatment somewhat detailed descriptions different types therapies used treatment psoriasis given phototherapy shown good therapeutic option various types skin diseases use natural therapy diminished people move towards artificial phototherapy like narrow band uvb broad band uvb puva targeted phototherapy main advantages treatments safe reduce erythema following treatment regarding safety issue targated phototherapy pay attention towards researcher
showed previously higher levels csf dopamine hiv patients associated presence dopamine transporter dat repeat allele also detected frequently hiv infected individuals compared uninfected subjects current study investigated whether genetic dopamine related polymorphisms may related changes csf levels frequency hiv infection hiv infected subjects specifically studied genetic polymorphisms brain derived neurotrophic factor catechol methyltransferase dopamine receptors drd drd drd genetic polymorphisms uninfected hiv infected people two different ethnical groups german cohort caucasian individuals hiv infection individuals without hiv infection south african cohort xhosan individuals hiv infection individuals without hiv infection correlated polymorphisms csf levels hiv dementia score cell counts hiv viral load none investigated related polymorphisms associated altered csf levels cell count viral load hiv dementia score respective allele frequencies equally distributed hiv infected patients controls findings show influence studied genetic polymorphisms csf levels hiv infection contrast found previously dat utr vntr highlights specific role dat vntr hiv infection disease
solve year old open problem depth optimality sorting networks donald knuth detailed sorting networks smallest depth known inputs quoting optimality volume art computer programming parberry proved optimality networks inputs present general technique obtaining results proving optimality remaining open cases inputs exploiting symmetry construct small set two layer networks depth sorting network inputs one whose first layers network construct propositional formula whose satisfiability necessary existence depth sorting network using shelf sat solver prove optimality sorting networks listed knuth inputs algorithm orders magnitude faster prior ones elsevier inc rights reserved
sought determine whether low magnitude mechanical stimulation lmms normalizes bone turnover among adolescents hospitalized anorexia nervosa brief daily lmms prevents decline bone turnover typically seen bed rest lmms may application patients inpatient setting protect bone health malnourished adolescents requiring medical hospitalization high risk rapid reduction skeletal quality even short term bed rest suppress normal patterns bone turnover sought determine whether lmms normalizes bone turnover among adolescents hospitalized complications randomized double blind trial prospectively enrolled adolescent females age years mean bmi participants randomized stand platform delivering lmms placebo platform min day days serum markers bone formation bone specific alkaline phosphatase bsap turnover osteocalcin bone resorption serum telopeptides ctx measured random coefficients model constructed estimates confidence intervals outcomes bsap decreased per day placebo arm remained stable lmms group diff ctx change placebo increased lmms arm per day diff serum change either group bed rest hospitalization patients associated suppression bone turnover may contribute diminished bone quality brief daily lmms prevents decline bone turnover bed rest protocols prescribing strict bed rest may appropriate protecting bone health patients lmms may application patients inpatient setting
study general techniques implementing distributed data structures top future many core archi tectures non cache coherent partially cache coherent memory goal contributing towards might become future concurrency utilities package java collections architectures end comprehensive collection data structures considering different variants techniques achieve scalability study generic scheme makes implementations hierarchical also describe collection techniques improving scalability implementations performed experiments illustrate nice scalability characteristics proposed techniques reveal performance scalability power hierarchical approach distill experimental observations metric expresses scalability potential implementations finally present experiments study energy consumption aspects proposed techniques using energy model recently proposed architectures
study optimization problems extended flexible objective namely ordered median function omf omf incorporates large number objectives one function concrete objectives given choosing values parameter vector using optimization problems extended omf one model solution algorithm implementation necessary analyze many concrete objectives paper propose general framework model optimization problems extended omf approach based formulation omf using partial sums sorted values problem independent applied optimization problem linear mixed integer linear representation set feasible solutions available furthermore applied without linearizations using presented modeling framework practioners able compare evaluate different objective functions without changing model implementation especially useful early stage problem solving adequate objective yet known exemplarily show approach applied optimization problems areas location routing scheduling elsevier rights reserved
study supply function competition among conventional power generators different levels flexibility impact intermittent renewable power generation competition inflexible generators commit production uncertainties realized whereas flexible generators adjust production uncertainties realized types generators compete electricity market submitting supply functions system operator solves two stage stochastic program determine production level generator corresponding market prices aim gain understanding conventional generators flexibility renewable energy intermittency affect supply function competition market price find classic supply function equilibrium model overestimates intensity market competition even intermittent generation introduced system policy economically curtailing intermittent generation intensifies market competition reduces price volatility improves system overall efficiency furthermore benefits economic curtailment significant production based subsidies renewable energy absent
study exponential behaviour stabilizability following abstract nonlinear stochastic evolution equation partial derivative sigma sigma multiplicative white noise time spatial correlation applications concrete models fluid mechanics also given
study problem inverse minimum dynamic cut imdc changes capacity vector way given dynamic cut applied changes minimum using euclidean norm measure changes aim solve inverse minimum dynamic cut finding maximum dynamic flow time expanded network flow calculated appropriate algorithm analyzing relationships time expanded networks maximum flow minimum cut first show specified dynamic cut optimized capacity arcs reduced study useful cases network divided two parts cutting cut minimum weight applicable physics chemistry computer networks electrical circuits etc advantage method use time expanded network static corresponding dynamic network algorithm easily displayed network finally algorithm implemented numerical example dynamic network flow
suggest new mathematical model dynamical suspension bridge energy dependent boundary conditions roadway bridge viewed long narrow thin rectangular plate reducing evolution problem corresponding model variational problem show original evolution problem admits unique solution moreover unique solution explicitly represented
used seemingly unrelated partially linear model suplm address potential correlation pollutants nitrogen phosphorous dissolved oxygen mercury environmental kuznets curve study simulation studies show suplm performs well address potential correlation among pollutants find relationship income pollution follows inverted shaped curve nitrogen dissolved oxygen cubic shaped curve mercury model specification tests suggest suplm better specified compared parametric model study income pollution relationship results suggest need continually assess policy effectiveness pollution reduction income increases
used additive manufacturing printing create ordered porous beds range geometric shapes including truncated icosahedra approximating spheres tetrahedral octahedral triangular bipyramid stellar octangular particles show printed porous media highly reproducible excellent fidelity physically reproducing computer aided design models differences designed experimentally measured particle locations within within terms bed porosity experimental residence time distributions measured reduced plate height determined different reduced velocities peclet number results using equivalent particle diameter non dimensionalize show simple cubic arrangement tetrahedral particles lower plate height min particle shapes tested including spherical particles also first time experimentally validated computational predictions performance body centered cubic bcc face centered cubic fcc arrangements spheres confirming fcc indeed superior min min conclude capability offered additive manufacturing controlling packing configuration also shape position orientation geometric elements within porous bed may future play fundamental role design highly efficient printed columns elsevier ltd rights reserved
used method moments mom numerical electromagnetic field computation method study surge characteristics twisted pair single phase electric power lines results show wires stranded less several turns per meter almost surge characteristics parallel lines surge impedance decreases tens number strands increases verify simulation results measured surge characteristics model line twisted pair experimentally good accordance possible simulate surge twisted pair covered polymer dielectric insulators mom moreover studied surge characteristics twisted pair inserted metal tube according results effect strand smaller free space without metal pipe two propagation modes common mode fast surge slow surge influences number strands surge velocity occur fast propagation surge increase surge impedance slowdown propagation speed caused twining slow propagation mode wiley periodicals inc electr eng jpn published online wiley interscience www interscience wiley com doi eej
web service discovery plays crucial role development applications based service oriented architecture due importance identifying services capable fulfilling requirements service requesters field software engineering web service discovery applied problem software component retrieval order facilitate reuse software components speed development new software projects unfortunately existing service discovery schemes unable perform task effectively due manual service queries lack support service queries using unified modeling language uml high degree complexity associated integration study proposes novel approach resolving situation referred scrumte service component retrieval uml modeling term expansion proposed system provides three functions generation lexically expanded term set candidate service service repository transformation required uml models wsdl web services description language documents use service queries integration web service retrieval mechanism identification services based textual similarities service integration system designed assist software developers search service components according specific requirements experiment results demonstrate search precision scrumte system far exceeds text based approaches
west nile virus wnv mosquito transmitted flavivirus belonging japanese encephalitis antigenic complex flaviviridae family transmitted primarily bite infected mosquitoes particularly culex spp aedes ochlerotatus spp acquire virus feeding viraemic birds humans horses mammals regarded incidental dead end hosts last decades increasing number cases wnv infection horses humans notified mediterranean basin tunisia human cases wnv related meningoencephalitis detected based analysis climatic environmental conditions found locations human cases reported aim study identify similar areas tunisia potentially risk disease occurrence data related neuroinvasive west nile fever wnf human cases georeferenced set environmental climatic variables wetlands humid areas normalized difference vegetation index ndvi temperatures elevation migratory bird settlements used analysis areas ecologically similar human cases detected identified using mahalanobis distance statistic leave one cross validation performed validate sensitivity model points correctly classified
wetlands important ecosystems known kidney earth particularly urban wetlands play important role providing natural social beneficial services however urban wetlands suffering various human impacts excessive land use conversion air water pollution especially developing countries undergoing rapid industrialization urbanization therefore great necessity derive timely biomass information optimal design management protection urban wetlands paper develop set models estimating ground biomass agb xixi national wetland park hangzhou china using optical images synthetic aperture radar sar images series vegetation indices vis derived optical data introduced along spectral data modeling methods consist curve estimation linear regression multivariable model back propagation neural network bpnn modeling curve estimation combination linear nonlinear regressions applied generate agb models single variable including normalized difference vegetation index ndvi radar backscatter coefficient models compared via three accuracy metrics according results sar models generally show better accuracy optical models bpnn models show greatest accuracy among models bpnn model combination terra advanced spaceborne thermal emission reflection radiometer aster european remote sensing satellite ers sar synthetic aperture radar image least root mean square rmse least mean absolute error mae greatest correlation coefficient results indicate agb estimated integrating optical sar imagery four maps agb derived illustrate distribution agb study area total agb study area estimated
known objectivebiopharmaceuticals important class drugs treatment autoimmune inflammatory oncologic diseases patent expiries biotechnological manufacturers develop biosimilar drugs due timeliness introducing new complex biosimilars portuguese association hospital pharmacists gathered develop common positioning use biosimilar monoclonal antibodies main issuesthe european pathway biosimilar approval developed improve affordability access biological therapies remains work progress unresolved issues remain due present reality biosimilar monoclonal antibodies hospital pharmacists must play important role ensuring safe effective cost effective use biosimilars health systems educating healthcare administrators providers legislators policymakers payors patients products new conclusionthe conclusions presented work focused proposal optimal biosimilar prescription criteria preparation original biologics biosimilars pharmacy management selection suppliers extrapolation issues specific role pharmacovigilance risk management optimal use biosimilar monoclonal antibodies
known objectivedrug induced lupus erythematosus occurs drugs resolves withdrawal anti tnf therapies found associated lupus like syndrome clinically distinct classical drug induced well idiopathic lupus erythematosus case descriptionwe describe case patient severe psoriasis developed muscle pain paraesthesia accompanied ana titres elevation adalimumab treatment condition resolved adalimumab cessation patient started ustekinumab good results new conclusionustekinumab might useful treatment option patients history tnf induced lupus like syndrome
known objectivekaposi sarcoma malignant neoplasm caused hhv pathogen leads endothelial cell transformation host defences weakened case descriptionhere report first case treatment abatacept biologic agent targeting cell costimulation patient year old female rheumatoid arthritis developed multiple firm purple reddish nodules dorsal aspect right hand histological examination confirmed new conclusionalthough direct causal relationship development abatacept treatment proved hypothesize role costimulation blockade
known objectiveoral anticoagulants oacs used decades long term prevention arterial venous thromboembolic disease include warfarin newer direct acting oacs doacs data real life prescribing patterns doacs limited commentary report prescribing patterns oacs wales representative country within commenta retrospective analysis anonymized oac prescribing data wales june december results reveal number oac prescription items increased per prescribing unit average cost increased pound pound per share warfarin prescribing declined rising share doacs made rivaroxaban apixaban dabigatran new conclusionanalysis real life data demonstrates increase overall numbers costs oac prescriptions rising proportion doacs warfarin prescribing
kirchhoff actually concerning spanning trees course classic paper annalen der physik und chemie extent long shrouded myth literature graph theory mathematical chemistry review kirchhoff manipulation equations arise application two celebrated laws electrical circuits formulated middle century related century work enumeration spanning trees shown matrices encountered analysis kirchhoff really include kirchhoff laplacian admittance matrix features well known matrix tree theorem matrix encountered theorem gutman mallion essam applicable planar graphs analogous matrix arises cycle theorem kirby theorem applies graphs genus concluded kirchhoff interested counting spanning trees accordingly explicitly nevertheless shown modulus determinant certain matrix denoted label associated linear equations arising application kirchhoff two laws numerically equal number spanning trees graph representing connectivity electrical network studied kirchhoff however invoke concept spanning trees introducing complementary fashion referring chords must removed original graph order form trees emphasised choosing cycles network studied around apply circuit law kirchhoff explicitly selected would called fundamental system cycles
narrative deemed compelling justify anti immigrant sentiments country economy cause concern predicted flourishing economies constrain viability realistic threat arguments found support prediction experiment participants asked take role speechwriter leader anti immigrant message predicted greater percentage realistic threat arguments fewer symbolic threat arguments generated condition economy expected decline expected grow baseline condition perhaps interesting economic growth condition percentage realistic entitlements symbolic threat arguments generated higher economy declining conclude threat narratives provide legitimizing discourse anti immigrant sentiments tailored economic context
active muscles stretched understanding muscle function stretched well understanding molecular mechanisms concentric contraction advanced considerably since advent sliding filament theory whereas mechanisms increased force production eccentric contraction becoming clearer eccentric contractions play important role everyday human movements including mobility stability muscle strength shortly sliding filament theory muscle contraction introduced reluctant recognition muscle behaved contained elastic filament jean hanson hugh huxley referred structure filament though concept gained little traction additional filament giant titin protein identified several decades later roles muscle contraction still discovered recent research demonstrated like activation thin filaments calcium titin also activated muscle sarcomeres mechanisms elucidated mdm mutation mice appears prevent activation titin promising model system investigating mechanisms titin activation titin stiffness appears increase muscle force production providing mechanism explains two fundamental properties eccentric contractions high force low energetic cost high force low energy cost eccentric contractions makes particularly well suited athletic training rehabilitation eccentric exercise commonly prescribed treatment variety conditions including sarcopenia osteoporosis tendinosis use eccentric exercise rehabilitation athletic training exploded include treatment elderly well muscle bone density maintenance astronauts long term space travel exercise intolerance many types sports injuries experimental evidence suggests interventions involving eccentric exercise demonstrably superior conventional concentric interventions future work promises advance understanding molecular mechanisms confer high force low energy cost eccentric contraction well signaling mechanisms responsible beneficial effects eccentric exercise athletic training rehabilitation
confronted unfamiliar object person privately owned pet dogs engage social referencing synchronizing reaction owners question whether shelter dogs confronted stranger yet studied tested reactions shelter dogs principal caregiver confronted stranger approaching neutral manner caregivers instructed behave one three ways toward stranger stay still approach retreat shelter dogs showed referential looks gaze alternations stranger caregiver however shelter dogs modify reactions towards stranger accordance behaviour caregivers thus confronted stranger shelter dogs show social referencing handlers contrary privately owned pet dogs owners findings highlight social deprivation dogs shelters confronted emphasize importance affiliative bond humans dogs creating social referencing elsevier rights reserved
construction craft workers consider potential career alternatives overall job satisfaction fundamental factor influences retention productivity paper analyzes changes job satisfaction job preferences craft workers construction industry across successive economic recession expansion cycles analysis used data general social survey gss collected compared job satisfaction preferences construction craft workers industries authors found job preferences sampled construction respondents changed successive recession expansion cycle desire high income became prevalent sense accomplishment physical work traditionally top job preference among construction workers general overall job satisfaction among sampled construction respondents equal slightly exceeded overall job satisfaction sampled respondents industries industry craft recruitment efforts use insights design future recruitment retention strategies
determining effects light human beings essential correctly measure effects correctly measure adequate properties light therefore important know measured know quality measurement devices paper describes simple methods identifying three quality indices directional response index linearity index temperature index indices also checked several commonly used portable light measurement devices results stresses already assumed quality outcome devices different circumstances different also location devices normally worn impact results deviation range worn vertically eye level wrist outdoor indoor smallest deviation indoor outdoor found device placed sides eye author published elsevier ltd
descriptive regularities characteristics individuals become prescriptive norms characteristics individuals examined children years adults use group regularities make prescriptive judgments employing novel groups hibbles glerks engaged morally neutral behaviors eating different kinds berries participants introduced conforming non conforming individuals hibble ate berries typical glerk children negatively evaluated non conformity negative evaluations declining age study effects replicable across competitive cooperative intergroup contexts study stemmed reasoning group regularities rather reasoning individual regularities study data provide new insights children group concepts important implications understanding development stereotyping norm enforcement
forming impressions trying figure people behave way take account dispositional factors personality traits also situational constraints potential causes behavior however attributions people often ignore importance situational factors investigate neural mechanisms underlying integration situational information attributions decomposed attribution process separately presenting information behaviors situational circumstances occur reading information participants judged whether dispositional situational causes explained behavior attribution much liked person described scenario affective evaluation dorsolateral prefrontal cortex showed increased blood oxygenation level dependent activation encoding situational information resulting attribution situational relative attribution dispositional potentially reflecting controlled process integrates situational information attributions interestingly attributions strongly linked subsequent affective evaluations dorsomedial prefrontal cortex emerging potential substrate integration attributions affective evaluations findings demonstrate top control processes regulate impression formation situational information taken account understand others
imitating novel actions typically developing preschoolers often copy components demonstration unrelated modeled action goal phenomenon known overimitation according social motivation account overimitation fulfills social affiliation motives imitator drive experience social connectedness demonstrator social context conversely according social cognitive account overimitation reflects overattribution causal relevance imitator failure appreciate components demonstration relevant action outcome autism spectrum disorder asd william syndrome characterized reduced enhanced spontaneous social motivation respectively well similar impairments social cognition thus providing helpful test cases understand nature overimitation using novel eye tracking paradigm examined overimitation preschoolers asd age matched peers age matched typically developing children found children typically developing children likely overimitate increase attention model face demonstration causally irrelevant actions compared asd findings discussed context support social motivational account overimitation elsevier rights reserved
johann daniel bernoulli founded fluid dynamics encountered several problems beyond vision newtonian particles new set images needed order deal spatial extensibility lack form fluids point evidence analogy essential abductive strategy creation imagery heuristic behavior complex analogy provide initial model proto model establishes starting point theoretical process play roles well historical genesis analyzed shows participation analogy physicists creativity restricted richness opens field different roles strategies model based discovery processes analogies crop intermittently evolution theory cooperate images extreme case reasoning thought experiments even activate processes origin although may seem contributions analogy generative sense helping discover new aspects reality must stress evaluative function sometimes performed analogical reasoning order gain confidence study bernoulli genesis foundations fluid dynamics generates interesting hypotheses multiple roles analogy play scientific model based reasoning
switching automatic output quality testing systems aspiration improving detectability insignificant deviations output parameters statutory ones necessitates solution number new problems one assessing effect image energy spectral density axisymmetric flaw reliability detection background noise human computer vision systems knowing information necessary condition developing new enhanced testing evaluating techniques results presented probabilities false alarm correct detection axisymmetric circular rectangular flaws depending signal noise ratio snr ratio flaw radius background fluctuation correlation radius established small snr human vision effective machine vision implements correlation detector algorithm neyman pearson criterion
upper lower regions different emotionless faces aligned form facial composite observers fuse two halves together perceptually illusory distortion induced task irrelevant distractor halves hinders participants judgements task relevant target halves composite face effect reveals tendency integrate feature information disparate regions intact upright faces consistent theories holistic face processing however observers frequently perceive emotion ostensibly neutral faces contrary intentions experimenters study sought determine whether perceived emotion influences composite face effect first experiment confirmed composite effect grows stronger strength distractor emotion increased critically effects distractor emotion induced weak emotion intensities incidental insofar emotion cues hindered image matching emotion labelling per experiment found correlation presence perceived emotion set ostensibly neutral distractor regions sourced commonly used face databases strength illusory distortion induced experiment participants completed sequential matching composite task half distractor regions rated high low perceived emotion respectively significantly stronger composite effects induced high emotion distractor halves convergent results suggest perceived emotion increases strength composite face effect induced supposedly emotionless faces findings important implications study holistic face processing typical atypical populations
using amorphous material electric motor losses often higher expected paper investigates effect cutting annealing performance amorphous material curve losses compared annealing treatment furthermore properties compared material cut plate shear cut laser followed annealing treatment case study done high speed motor comparing amorphous material conventional silicon steel grade based fem analysis reduction iron loss factor found use amorphous material instead conventional silicon steel
conserve energy resources systems environment enjoy cleaner air healthier help protect climate reducing heating due energy consumption energy efficient medical equipment design latest research medical science scientists focus shifting toward energy efficient medical system design ecg machine commonly used medical equipments equipment consuming less power environment climate whole medical regions move greener pollution less energy efficient finally reduces cost medical treatment save energy consumptions work going design implement energy efficient ecg machine using lvdci low voltage digitally control impedance sstl stub series terminated logic hstl high speed transistor logic standard
whereas previous research environmental factors implicated intergenerational transmission depression tended focus role parenting quality harshness current study sought assess whether structural aspects families may contribute depression relevant affective immune processes youths specifically present study examined role family routines linking parental depressive symptoms youth emotion regulation depression relevant marker low grade inflammation depressive symptoms youths parent adolescent dyads reported depressive symptoms family routines youths emotion regulation abilities addition peripheral blood drawn youths assess levels proinflammatory cytokine interleukin path analyses provided support model parental depressive symptoms related fewer family routines turn associated higher depressive symptoms youths well marginally associated worse youth emotion regulation moreover family routines found statistically account part association parent youth depressive symptoms together results suggest family routines may represent additional facet family environment potentially contribute intergenerational transmission depressive symptoms
whereas studies demonstrated impaired working memory among patients borderline personality disorder bpd findings consistent furthermore lack neurophysiological evidence function patients bpd goal study examine function patients bpd using event related potentials erps additional goal explore whether characteristics bpd impulsiveness emotional instability associated impairment modified version back task back used measure erps recorded bpd patients age handedness sex matched healthy controls hcs performed task results revealed significant group differences behavioral variables reaction time accuracy rate latencies amplitudes bpd patients lower amplitudes longer latencies independent load low load back high load back impulsiveness correlated latency amplitude correlations found latency amplitude affect intensity scores load conclusion lower amplitudes longer latencies bpd patients suggested might dysfunction neural activities sub processing impulsiveness negative affect might close relationship deficits
whether smart cities ambient intelligence internet things current visions future urban spaces share common core namely increasing role distributed sensor networks demand integration data power real time services analytics greatest hurdles implementing visions include security risks user privacy scalability integration heterogeneous data financial cost work propose crowdsensing mobile device platform empowers citizens collect share information surrounding environment via embedded sensor technologies approach allows variety urban areas university campuses shopping malls city centers suburbs become equipped free hoc sensor network without depending proprietary instrumentation present framework namely geotracer application proof concept conduct multiple experiments simulating use case scenarios university campus first demonstrate ambient sensors temperature pressure humidity magnetism illuminance audio help determine change environment moving indoors outdoors floor changes inside buildings accurately typical positioning technologies global navigation satellite system etc furthermore sensors contributes different amount data detecting events example illuminance highest information gain trying detect changes indoors outdoors second show platform possible detect differentiate place types university campus based inferences made ambient sensors lastly train classifiers determine activities place afford different times good studying basketball courts use empty based sensor driven semantic signatures
whether theory mind tom preserved alzheimer disease remains controversial subject recent studies showed performance tom tests might altered though lesser extent behavioural variant frontotemporal dementia bvftd however unclear reflects genuine impairment tom deficit secondary general cognitive decline observed aiming investigate cognitive determinants tom performance data mining study conducted patients replicated independent age matched group patients perform independent replication results bvftd patients included comparison group patients extensive neuropsychological examination hierarchical clustering analyses showed tom performance clustered measures executive functioning tom performance also specifically correlated executive component extracted principal component analysis final step automated linear modelling conducted determine predictors tom performance showed tom performance significantly predicted executive measures similar findings across analyses observed independent group patients thereby replicating results conversely tom impairments bvftd appeared independent cognitive impairments results suggest difficulties patients tom tests reflect genuine tom deficit rather mediated general particularly executive cognitive decline also suggest key role mental state attribution support interacting models tom functioning finally study highlights relevancy data mining statistical approaches clinical cognitive neurosciences elsevier ltd rights reserved
whetherwell documented patterns mental health comorbidity adolescent combustible cigarette use extend cigarette use unclear demonstrating associations cigarette combustible cigarette use mental health symptomatology across adolescence may important promoting accurate perceptions populations risk potential consequences tobacco product use adolescents mean age baseline female hispanic never previously used combustible cigarettes assessed baseline month follow ups los angeles logistic regression used examine associations baseline depressive symptoms onset cigarette cigarette single product dual use follow ups latent growth modeling used examine associations sustained use either product non use changes depressive symptoms months higher baseline depressive symptoms predicted subsequent onset cigarette cigarette dual use products sustained use cigarettes month observation non use associated greater rate increase depressive symptoms time among sustained use cigarettes higher frequency use associated higher depressive symptoms final follow directional association depressive symptoms cigarette use onset across mid adolescence observed research causal nature etiological underpinnings intervention implications mental health tobacco product use comorbidity warranted elsevier inc rights reserved
bone mineral density traditionally used quantify fracture risk individuals spinal cord injuries recent studies including engineering measurements section modulus cross sectional moment inertia almost exclusively calculated peripheral qct scanners unlike dxa scanners rarely found clinical settings using fifty four fresh frozen femora developed validated pixel pixel method calculate engineering properties distal femur using hologic qdr dxa scanner compared similar parameters measured using stratec xct peripheral qct scanner found excellent agreement standard dxa pixel pixel measured bmd cross sectional moment inertia anteroposterior axis measured using dxa pqct correlated strongly cross sectional moment inertia anteroposterior axis measured using dxa also correlated strongly pqct measured bone strength index correlations indicate dxa scans measure equivalent pqct parameters existing dxa scans reprocessed pixel pixel techniques ultimately engineering parameters may help better quantify fracture risk fracture prone populations spinal cord injuries
early intermediate results fontan palliation greatly improved survival quality life patients single ventricle physiology late complications remain concerning leave room improvement addition recent advances surgical techniques post operative care advances medical imaging related technologies improve pre surgical planning post operative management complex patients novel technologies including advanced mri computer aided design three dimensional printing virtual surgery computational fluid dynamics may provide better patient specific surgical plans continue improve long term outcomes elsevier ireland ltd rights reserved
exposure adverse family experiences afes subset adverse childhood experiences aces associated childhood obesity less known impact exposures type afe using national survey children health data evaluated associations exposure individual afes overweight obesity status children years older adjusting socio demographic factors caregivers reported child height weight exposure nine afes body mass index bmi classified center disease control prevention cdc guidelines mayo clinic calculated frequencies weighted estimates socio demographic factors afes unadjusted adjusted weighted multinomial logistic regression models employed assess independent associations afe different afe composite scores bmi category exposure two afes independently associated increased odds overweight odds ratio confidence interval obese status adjustment age household income parents education level race sex death parent hardship due family income independently associated obesity status adjustment afes socio demographic factors results suggest addition cumulative exposure afes exposure certain childhood experiences strongly associated childhood obesity others death parent hardship due family income individual afes strongly predictive obesity elsevier inc rights reserved
many schemes proposed search encrypted relational databases less attention paid nosql databases paper report design implementation security scheme called securenosql searching encrypted cloud nosql databases solution one first efforts covering data confidentiality also integrity datasets residing cloud server system secure proxy carries required transformations cloud server modified construction applicable nosql data models experiments present application document store data model contributions paper include descriptive language based subset json notations tool create parse security plan consisting cryptographic modules data elements mappings cryptographic modules data fields query data validation mechanism based security plan elsevier ltd rights reserved
online interventions increasingly explored alternative therapist based interventions cancer related distress limitations efficacy potentially include low uptake adherence predictors uptake adherence online interventions consistently identified particularly individuals cancer study examined rates predictors uptake adherence finding way rct online intervention versus information online control cancer related distress participants adults cancer treated curative intent adherence assessed login frequency duration activity level analyses examined demographic medical psychological predictors uptake adherence study enrolled adults aged years undergoing active treatment cancer type uptake highest females individuals ovarian breast cancer lowest melanoma adherence predicted older age control group allocation baseline distress levels predict adherence high adherers full intervention better emotion regulation quality life low adherers uptake online intervention varies according age gender cancer type uptake higher amongst younger individuals enrolled older individuals likely adhere online interventions cancer related distress
onsite measurement air permeability provides useful approach assess service life concrete structures combined use onsite laboratory measurement air permeability useful anticipate whether target service life achieved investigation developed within aim founding application air permeability test torrent method based experimental observation specimen geometry surface influence air permeability results experimental program developed considering three specimen geometries two types surface twelve concrete mixes results analysed significant influence tested specimens geometry surfaces detected therefore use surfaces specimens geometry mix approval compliance control processes possible without correction results work constitutes contribution understanding test method particular concrete air permeability assessment general
previous studies examined motivational aspects self directed violence studies included specific motivations predictive models future suicide attempts current study utilized sample individuals treated acute emergency setting following suicide attempt completed interview battery included assessment functional aspects index suicide attempt follow interview conducted months ascertain subsequent suicide attempts functional domains suicide attempts labeled reduction distress communication perceived better alternative living self loathing beyond known risk factors including history highest lethality previous self injury suicide attempts served communication function higher ratings clinical dysfunction associated significant reduction likelihood engage suicide attempt month follow window including perceived effectiveness index suicide attempt getting one needs met strengthened overall model predicting suicide attempt follow window independent risk factor beyond variables model assessment functional aspects suicide attempt feasible may improve formulation risk population typical risk factors suicide ubiquitous
previous studies suggested perfusion abnormalities parkinson disease driven dementia study aimed identify perfusion underpinning cognitive alteration non demented patients cerebral blood flow measured using arterial spin labelling asl patients age years age matched healthy controls age years also underwent neurological cognitive testing pseudocontinuous asl weighted scans patients analysed voxel wise manner using spm software associations asl values volumes interest vois behavioural cognitive measures assessed spearman correlation analysis posterior cortical hypoperfusion found patients compared left supramarginal gyrus superior temporal gyrus voi left posterior cingulate precuneus voi positive correlation revealed perfusion voi addenbrooke cognitive examination revised ace scores filtering effect age levodopa equivalent dose led total intracranial volume tiv conversely negative correlation voi ace detected regressing effects motor impairment age led tiv non demented subjects blood flow abnormalities precuneus posterior cingulate linked level motor impairment global cognitive performance oppositely perfusion abnormalities supramarginal gyrus might serve compensatory mechanism brain degeneration decreased cognitive performance
previous work focused positive impact smiles interpersonal perceptions research proposes finds smile intensity differentially affects two fundamental dimensions social judgments warmth competence marketer displaying broad smile compared slight smile likely perceived consumers warmer less competent furthermore facilitative effect smile intensity warmth perceptions prominent among promotion focused consumers low risk consumption contexts detrimental effect smile intensity competence perceptions likely occur among prevention focused consumers high risk consumption situations field observations crowdfunding context indicate effects smile intensity warmth competence perceptions downstream consequences actual consumer behaviors
hominin fossil record inform either presence extent social cognitive abilities may paved way emergence language studying non vocal communication among closest living relatives african apes may provide valuable information language originated although much learned gestural signaling non human primates yet established gestural repertoires vary across species factors influence variation knowledge differences contribute understanding gestural signaling contribution language evolution paper review arguments surrounding theory language evolved gestural signaling suggest important factors consider conducting comparative studies gestural communication among african apes specifically propose social dynamics positional behavior critical components shape frequency nature gestural signaling across species argue understanding factors could shed light gestural communication may basis human language outline predictions influence factors frequencies types gestures used across african apes highlight importance including factors future gestural communication research primates primatol wiley periodicals inc
practice rainwater harvesting rwh traced back millennia degree modern implementation varies greatly across world often systems maximize potential benefits global focus pertinent practical theoretical social aspects rwh reviewed order ascertain state art avenues future research also identified major finding degree rwh systems implementation technology selection strongly influenced economic constraints local regulations moreover despite design protocols set many countries recommendations still often organized objective conserving water without considering potential benefits associated multiple purpose nature rwh suggested future work rwh addresses three priority challenges firstly empirical data system operation needed allow improved modelling taking account multiple objectives rwh systems secondly maintenance aspects may impact quality collected rainwater explored future way increase confidence rainwater use finally research devoted understanding institutional socio political support best targeted improve system efficacy community acceptance elsevier ltd rights reserved
turkey mostly muslim country officially secular country traditional gender roles still maintained homosexuality taboo subject turkish sporting world exception also excludes ignores existence homosexuals homosexuality using single case study study aimed contribute fill gap understudied subject homosexuality physical education sports literature investigating experiences gay male turkish sports major respondent aged fourth year undergraduate student time purposive sampling used select respondent based willingness participate study semi structured interview allowed data collected regarding gay turkey particular sports environment four major themes derived analysed interview data conflicting feelings coming closet life turkish community life sports department perceived roots homophobia findings indicated respondent disclosure sexual orientation friends resulted positive reactions however still hesitates acknowledge homosexuality publicly traditional gender roles misconceptions homosexuality homosexuals religion perceived influential factors homophobic attitudes behaviour turkish society experiences turkey world sports rife homophobia
white light coronal heliospheric imagers observe scattering photospheric light dust particles corona free electrons corona corona separation two coronae thus vitally important reveal faint coronal structures streamers rotating interaction regions coronal mass ejections etc however separation two coronae difficult content defining background corona contains little possible lasco lasco coronagraphs aboard solar heliospheric observatory soho white light imagers secchi suite aboard solar terrestrial relationships observatory stereo time dependent model background corona generated month similar images creation models possible missions carrying instruments orbiting sun however orbit profiles upcoming solar orbiter solar probe plus missions different missions elliptic orbits rapidly changing radial distance hence invalidating techniques use soho lasco stereo secchi instruments investigating techniques generate background models single images could used solar orbiter heliospheric imager wide field imager solar probe plus packages board respective spacecraft paper introduce state art heuristic technique create background intensity models stereo data based solely individual images report new results derived application discuss relevance instrumental operational issues
elites authoritarian regimes others remove power leaders harm interests develop formal theory explaining theory shows elites ambition prevents controlling authoritarian leaders ambitious elites willing stage coups acquire power even leader good ambition renders elites claims leader actions harm less credible making elites less likely support coups show impact proportion competent politicians personalist regimes non monotonic personalist regimes likely emerge competent politicians also lots also provide insight elites become coup plotters theory explains emergence personalist regimes frequency coups authoritarian countries enjoy competent leadership others
people vote design field experiment estimate model voting others ask expectation asked motivates turnout individuals derive pride telling others voted feel shame admitting vote provided lying costly door door survey election turnout experimentally vary informational content use flyer pre announcing survey duration payment survey incentives lie past voting experimental results indicate significant social image concerns congressional election estimate value voting tell others contributing percentage points turnout finally evaluate get vote intervention tell potential voters ask voted
wide spread monitoring cameras construction sites provide large amount information construction management emerging computer vision machine learning technologies enables automated recognition construction activities videos executors construction activities construction workers strong impact productivity progress compared machine work manual work subjective may differ largely operation flow productivity among different individuals hence handful work studies vision based action recognition construction workers lacking publicly available datasets one main reasons currently hinder advancement paper studies worker actions comprehensively abstracts common types actions kinds trades establishes new real world video dataset instances action recognition cutting edge video description method dense trajectories applied support vector machines integrated bag features pipeline action learning classification performances multiple types descriptors histograms oriented gradients hog histograms optical flow hof motion boundary histogram mbh combination evaluated discussion different parameter settings comparison state art method provided experimental results show system codebook size mbh descriptor achieved average accuracy worker action recognition outperforming state art result elsevier ltd rights reserved
wifi offloading mobile users opportunistically obtain data wifi rather cellular networks promising technique greatly improving spectrum efficiency reduce cellular network congestion consider system service provider deploys multiple wifi hotspots offload mobile traffic study scheduling policy maximize amount offloaded data since users movements unpredictable focus online scheduling policy aps knowledge users mobility patterns study performance online policies comparing optimal offline policy prove work conserving policy able offload least half much data offline policy propose online policy requested data user large policy offload much data offline policy euler constant study case service provider increase capacity wifi provide guarantees amount offloaded data derive lower bound trade capacity amount offloaded data propose simple online policy achieves lower bound addition show policy needs half much capacity current mechanisms provide performance guarantee
wind power clean renewable resource rapidly becoming important component sustainable development resource transfer however construction wind farms impacts environment subject considerable research study verified whether china satellite could used monitor million kilowatt wind power grassland construction area jiuquan city gansu province monitoring performed comparing imaging results landsat oli china satellite performed interactive interpretation remote sensing images verified accuracy interpretations using measured field data evaluated pieces wind turbine equipment average construction density per device construction single wind turbine found damage nearly grassland average area grassland damaged turbines respectively approximately farmland occupied wind power construction accounted approximately study area roads covered farmland occupied wind power construction average difference measured calculated image data overall interpretation accuracy approximately therefore use comprehensive imaging analyses image data feasible monitoring grasslands construction wind power addition impacts wind farm construction vegetation destruction soil erosion discussed study grassland wind farms explored using remote sensing tools guide decision making regards rational use grassland resources sustainable development elsevier rights reserved
wind turbine generators wtgs consist many different components convert kinetic energy wind electrical energy end users wind energy accessed provide mechanical torque driving shaft electrical generator conversion wind power mechanical power governed aerodynamic conversion aerodynamicelectrical conversion efficiency wtg influenced efficiency blades gearbox generator power converter paper describes use matlab simulink simulate electrical grid related aspects wtg coupled fast aero elastic wind turbine computer aided engineering tool simulate aerodynamic mechanical aspects wtg combination two enables studies involving electrical mechanical aspects wtg example mechanical engineers formulate generator control may preserve life gearbox mitigate impact transient events occurring transmission lines faults voltage frequency dips unbalanced voltages etc similarly electrical engineers study impact high ramping wind speeds power systems well impact turbulence voltage frequency small balancing area
wireless sensor network wsn widely used environmental conditions systems depend sensing monitoring approach water pollution monitoring system depends network wireless sensing nodes communicate together depending specific topological order nodes distributed harsh environment detect polluted zones within wsn range based sensed data wsn exposes several malicious attacks consequence presence open environment additional techniques needed alongside existing cryptography approach paper enhanced trust model based use radial base artificial neural network rbann presented predict future behavior node based weighted direct indirect behaviors order provide comprehensive trust model helps detect eliminate malicious nodes within wsn proposed model considered limited power storage processing capabilities system
wireless sensor network wsn contains many specially distributed sensors collect information people analyze appointed objects real time wsn deployed widely many fields fire detection remote health care monitoring user authentication important part communication wsn jiang choi proposed authentication schemes wsn respectively however find weaknesses jiang scheme resist synchronization attack line guessing attack user forgery attack besides keep character strong forward security choi scheme line password guessing attack user impersonation attack without user anonymity present improved authentication scheme prove secure formal security model also analyze concrete secure characters performance scheme comparison recent schemes scheme practical fit applications
wireless sensor networks wsns become increasingly popular many applications across broad range fields securing wsns poses unique challenges mainly due resource constraints traditional public key cryptography pkc instance considered computationally expensive direct implementation wsns elliptic curve cryptography ecc allows one reach level security traditional pkc using smaller key sizes paper key distribution protocol designed securely provide authenticated motes secret system keys using ecc based cryptographic functions designed scheme met minimum requirements key distribution scheme considered secure efficient wsns
wireless sensor networks wsns emerged important research paradigm since last decade thereby motivating researches take new theoretical practical challenges wsns need provided efficient security features generally due deployment inaccessible terrain also communication wireless domain therefore question providing security networks arises major constraints limited resources present sensor nodes prior importance given energy parameter vital component sensor nodes objective intrusion detection framework would design robust mechanisms capable handling attacks energy efficient manner intrusion detection used wsns ability detect unknown attacks finding means thwart preserving energy therefore energy efficient intrusion detection become significant research area researchers keeping mind survey major topics energy efficient intrusion detection wsns survey work presents topics fundamentals intrusion detection techniques well various energy saving mechanisms used different architectural models earlier achievements energy efficient intrusion detection wsns also summarized existing problems discussed also give insight possible directions future work intrusion detection highlighting open research areas
wireless sensor networks already employed numerous applications including military industry health among several inherent limitations wireless sensor network security critical concern declared security functions wireless devices well verified study security testing method based security levels proposed wireless sensor networks addition experimental security testing platform wia based wireless sensor networks implemented test results show platform feasible platform assessing device security levels wireless sensor networks
united states based sample sexual minority men present study tested hypotheses derived objectification theory fredrickson roberts minority stress theory meyer prior research regarding men body image mccreary sasse specifically examined path model wherein objectification constructs internalized standards attractiveness body surveillance body dissatisfaction drive muscularity minority stress variable internalized heterosexism direct indirect predictors intention use anabolic androgenic steroids aas compulsive exercise results path model yielded adequate fit data regarding direct links internalized heterosexism correlated positively internalized standards attractiveness related positively body dissatisfaction internalized standards attractiveness related positively drive muscularity body surveillance drive muscularity related positively intention use aas compulsive exercise internalized standards attractiveness yielded significant positive indirect link intention use aas drive muscularity implications findings regarding application limitations objectification theory framework research practice sexual minority men discussed
experimental design assess reliability eyewitness identification viewing staged nonviolent crime subjects heard confederate provide inaccurate description criminal subjects randomly placed one several experimental conditions ability identify criminal assessed subjects highly confident ability accurately identify perpetrator ability provide accurate information perpetrator relatively low following shown significantly impact probability eyewitnesses could provide accurate eyewitness information length time subject witnessing crime asked identify perpetrator subjects physical distance witnessed crime content photo lineup whether criminal included prelineup instructions provided eyewitness similar prior research results highlight dangerous fallibility eyewitness identification particularly witness contamination
increased use forensic memory analysis soundness memory acquisition becomes important therefore present black box analysis technique memory contents constantly changed via payload application traceable access pattern way given correctness memory acquisition procedure evaluate atomicity one aspect integrity defined vomel freiling evaluated approach several memory acquisition techniques represented memory acquisition tools using windows bit operating system running gib ram found user mode memory acquisition software procdump windows task manager suspend process memory acquisition provide perfect atomicity integrity snapshots process memory cold boot attacks memimage msramdump virtualization virtualbox emulation qemu deliver perfect atomicity integrity full physical system memory snapshots kernel level software acquisition tools ftk imager dumpit windd winpmem exhibit memory smear concurrent system activity reducing atomicity integrity reduced running within imaged memory space hence overwriting part memory contents acquired least amount atomicity exhibited dma attack inception using ieee even dma performed completely hardware integrity violations respect point time acquisition let method appear inferior methods evaluation methodology generalizable examine memory acquisition procedures operating systems platforms authors published elsevier ltd behalf dfrws
increasing altitude solar radiation enhanced based phenomenon male biased sex ratio populus cathayana rehder high altitude alpine area hypothesized males faster sophisticated responsive mechanism high radiation females previous studies shown sexually different responses high radiation existed cathayana morphological physiological transcriptomic levels however responses proteomic level remain unclear study isobaric tag relative absolute quantification itraq based quantitative proteome analysis performed cathayana females males total proteins identified proteins defined differentially expressed proteins deps among deps decreased deps increased high solar radiation females males respectively bioinformatics analysis categorized common responsive proteins sexes related carbohydrate energy metabolism translation transcription post transcriptional modification photosynthesis redox reactions responsive proteins showed differences sex mainly involved amino acid metabolism stress response translation transcription post transcriptional modification study provides proteomic profiles poplars responding solar radiation also provides new insights differentially sex related responses radiation
participation high school sports rising number injuries sustained high school athletes also increased study sought investigate attributes sports injuries common injury sites male female athletes determine certain muscles strengthened prevent injuries high school athletes project utilizes anna anatomical network analysis show relationships musculoskeletal system high school sports injuries injury defined trauma musculoskeletal system study focused synovial joints human body include head injuries collected information three data sets develop three anatomical networks results showed articulation sites highest degree muscle bone account highest incidences sports injury common injury site female athletes ankle common injury site varied male athletes results also showed anatomical differences men women account different injury sites hypothesize strengthening gastrocnemius muscle would help prevent injuries knees ankles studies would need conducted
rapid urbanization highly accurate semantically rich virtualization building assets become critical supporting various applications including urban planning emergency response location based services many research efforts conducted automatically reconstruct building models city scale remotely sensed data however developing fully automated photogrammetric computer vision system enabling massive generation highly accurate building models still remains challenging task one challenging task building model reconstruction regularize noises introduced boundary building object retrieved raw data lack knowledge true shape paper proposes data driven modeling approach reconstruct rooftop models city scale airborne laser scanning als data focus proposed method implicitly derive shape regularity building rooftops given noisy information building boundary progressive manner study covers full chain building modeling low level processing realistic building rooftop modeling element clustering step building labeled point clouds clustered homogeneous groups applying height similarity plane similarity based segmented clusters linear modeling cues including outer boundaries intersection lines step lines extracted topology elements among modeling cues recovered binary space partitioning bsp technique regularity building rooftop model achieved implicit regularization process framework minimum description length mdl combined hypothesize test hat parameters governing mdl optimization automatically estimated based min max optimization entropy based weighting method performance proposed method tested international society photogrammetry remote sensing isprs benchmark datasets results show proposed method robustly produce accurate regularized building rooftop models
sufficient drug exposure individuals develop transient psychotic symptoms referred substance induced psychosis sip closely resemble symptoms observed schizophrenia spectrum disorders comparability psychotic presentation sip schizophrenias suggests similar underlying neural deficits may contribute emergence psychosis across disorders small number studies investigated structural alterations sip limited volumetric imaging methods none controlling effects chronic drug exposure investigate white matter abnormalities associated sip diffusion tensor imaging employed group individuals cocaine associated psychosis cap cocaine dependent non psychotic cdn group tract based spatial statistics used investigate group differences white matter diffusion parameters cap group showed significantly lower fractional anisotropy values cdn group voxels within white matter tracts fronto temporal fronto thalamic interhemispheric pathways greatest differences white matter integrity present corpus callosum corona radiata bilateral superior longitudinal fasciculi bilateral inferior longitudinal fasciculi additionally cap group voxels significantly higher radial diffusivity subset previously mentioned pathways results first description white matter integrity abnormalities sip sample indicate differences pathways may shared factor expression different forms psychosis
symbolic computation hirota method analytic two soliton solutions coupled nonlinear schrodinger cnls equations describe propagation spatial solitons algaas slab waveguide derived two types coefficient constraints cnls equations distinguish elastic inelastic interactions spatial solitons obtained first time paper asymptotic analysis made investigate spatial soliton interactions inelastic interactions studied obtained coefficient constraints cnls equations influences parameters obtained soliton solutions discussed optical switching soliton amplification studied based dynamic properties inelastic interactions spatial solitons numerical simulations good agreement analytic results presented results applications design birefringence managed switching architecture
constitution spain entered official history liberal constitutionalism one proclamations equality citizens spanish dominions however idea equality apparently within reach habitants territories beyond formal character contents correct various forms exclusion instance exclusion racial motives debates cortes cadiz reflect influences racial theories dominating science thus development constitutional principles idea citizenship embodied constitution limited racial prejudice impregnated century law present day law still exists
advanced materials industry makes especially machinery manufacturing industry witnessed rapid development become one important part therefore material engineering colleges focus development also become one disciplines train improve practical ability adapt needs society become important part college students training thesis explores materials engineering students professional training system establishment students presented material class materials processing skills training methods manufacturing engineering training high students practical ability engineering sense
advent component based software engineering cbse large software systems built integrating pre built software components semantic web association cbse shown offer powerful representation facilities reasoning techniques enhance support querying reasoning discovery etc software components goal paper research applicability semantic web technologies performing various tasks cbse review experimental results easy effective manner best knowledge first study provides extensive review application semantic web cbse different perspectives systematic literature review semantic web approaches employed use cbse reported conducted research article empirical results drawn question answer based analysis research clearly tells year wise trend research articles possible justification usage semantic web technology tools particular phase cbse conclude gaps current research potential future prospects discussed elsevier inc rights reserved
advent new technologies various services provided context computer networks large volume data generated main challenge area providing network protection services various threats vulnerabilities far many techniques proposed deal threats techniques pursue goal preventing attackers reaching objectives solution based early warning system ewss exactly security teams need manage threats properly ews complement intrusion detection system proactive approach security threats carried early detection potential behavior system evaluating scope malicious behavior finally using suitable response kind detectable security event paper presents comprehensive review ewss including definitions applications architectures alert correlation aspects technical requirements furthermore previous studies existing ewss described analyzed classification ewss presented commercial systems systems research development finally studies ewss conclude challenges research issues still remain open copyright john wiley sons ltd
development high technology war bionic autonomous underwater vehicle become popular issue years achieve better concealment stealth technology difficult problem must solved paper briefly introduces principle methods keep auv quiet difficult found advantages disadvantages extraction methods analyzed stealth technology underwater vehicle refers means make enemy sonar detect location shorten distance mainly including two aspects noise control acoustic antagonism finally development tendency bionic auv stealth technology provided
development multifunctional radar radio frequency stealth technology modern radar needs save much operating time possible process radar target tracking interacting multiple models imm paper proposes adaptive markov transition matrix update last step existing radar target tracking algorithms first take interacting multiple models main algorithm frame using gray relation particle swarm optimization pso multiple target adaptive sampling interval algorithm adopted pso process study two methods update markov transition matrix real time one ratio likelihood function compression ratio estimation error simulations illustrate method effective reducing operating time radars
development multimedia computer technology interactive projection becoming interactive display system entertainment people daily life interactive projector based actual needs design gesture based feature extraction algorithm moments identified svm classification shot type ultimately experiments verify effectiveness practicality system
development design complexity embedded systems hardware software partitioning becomes challenging optimization problem design novel partitioning method based position disturbed particle swarm optimization invasive weed optimization pdpso iwo presented paper found biologists ground squirrels produce alarm calls warn peers move away potential predatory threat present pdpso algorithm iteration squirrel behavior escaping global worst particle simulated increase population diversity avoid local optimum also present new initialization reproduction strategies improve iwo algorithm searching better position global best position updated search accuracy solution quality enhanced pdpso improved iwo synthesized one single pdpso iwo algorithm keep searching diversification searching intensification furthermore hybrid noderank hnoderank algorithm proposed initialize population pdpso iwo solution quality enhanced since communication cost computing time consuming process partitioning algorithm adopt gpu parallel technique accelerate computing way runtime pdpso iwo large scale partitioning problem reduced efficiently finally multiple experiments benchmarks state art publications large scale partitioning demonstrate proposed algorithm achieve higher performance algorithms
development satellite radio navigation system beidou user equipments found wide application capability equipments consequently attracts attention practical solution test devices design automatic test system aiming special test requirement simple introduction beidou navigation system test requirement user equipments given followed ate design detail including system structure implementation navigation signal emulator signal data process etc test result shows ate presented meet requirement test verify performance user equipments well
fast development solar energy harvesting technology various portable harvesters excellent energy capture properties highly desired especially devices used facades roofs buildings study proposed new energy absorption model integrating wave guiding polymer materials fluorescent substance coated textiles aimed address issues current energy shortage excessive pollutant emissions ambient environment besides textile based production multifunctional possessed compelling features solar radiation collection thermal insulation surface decoration compared conventional solar energy harvester fabricated device exhibited merits light weight better mechanical flexibility wider extended applicability study achieved progress area solar energy harvesting could possible informative effect future related research
flood publicly available data allows scientists explore discover new findings gene expression one type biological data captures activity inside cell studying gene expression data may expose mechanisms disease development however limitation computing resources knowledge computer programming many research groups unable effectively utilize data decade various web based data analysis tools developed analyze gene expression data different tools implemented different analytical approaches often resulting different outcomes study conducts comparative study three existing web based gene expression analysis tools namely gene set activity toolbox gat networkanalyst geor using six publicly available cancer data sets results case study show networkanalyst best performance followed gat geor respectively
implementation quality education higher vocational education occupies important position national education system takes task cultivation high quality talents knowledge national construction management production socialism ideological political education integral part educations colleges universities equally important higher vocational education recent years higher vocational education yielded series results ideological political education also encountered lot problems based background paper discusses path development ideological political education vocational college students perspective collaborative innovation
growing concern safety durability normal use function large important bridge research development bridge health monitoring system developed purpose paper realize system real time monitoring security analysis results show three dimensional visualization paper studies three dimensional visual model bridge real time security monitoring system according functional requirements system divided three parts graphics engine graphics engine database interface according idea modern software engineering complete set system architecture designed makes modules work high cohesion low coupling system system development methods modern software engineering based kinds design patterns skeleton integrated use modeling rendering technology gdi sql database technology mfc platform great progress combination computer software technology monitoring system time success system development trial prove greatly improves efficiency monitoring system bridge predict bridge safety hidden trouble ensuring safe operation bridge important role promote bridge monitoring technology development published elsevier ltd
help symbolic computation system maple riccati equation expansion method variable separation method complex wave solutions dimensional korteweg vries system derived based derived solitary wave solution novel complex wave localized excitations complex wave fusion complex wave annihilation investigated
increase global satellite navigation systems gnss limited number frequency bands current spectrum dedicated satellite navigation encounters congestion possible path keep modernizing different gnss find new frequency bands satellite radio navigation service rnss could provided article takes regulatory approach identify potential candidate bands reviewed detail assess usability new rnss deployment results analysis exist spaces spectrum rnss allocation exists could added example option consisting adding another rnss allocation aeronautical radio navigation service arns bands however allocation change planned would require important commitment administrations long negotiations civil aviation community use telecommunication signals opportunity coming hybrid satellite terrestrial network emitters among solutions would permit combine navigation telecommunication services offering huge opportunity mass market application
increase intelligent systems based multi agent systems mas use wireless sensor networks wsn context aware scenarios information fusion become essential part kind systems information distributed among nodes agents paper presents new mas specially designed manage data wsns tested residential home elderly proposed mas architecture based virtual organizations incorporates social behaviors improve information fusion processes data system manages analyzes correspond actual data activities resident data collected information event counts detected sensors specific time interval typically one day designed system improves quality life dependant people especially elderly fusioning data obtained multiple sensors information daily activities high development systems extract store information make essential improve mechanisms deal avalanche context data case mas approach results appropriated agent represent autonomous entity different capabilities offering different services collaborating among several tests performed evaluate platform preliminary results conclusions presented paper elsevier rights reserved
increasing deployment network systems network attacks increasing intensity well complexity along increasing network attacks many network intrusion detection techniques proposed broadly classified signature based classification based anomaly based deployable network intrusion detection system nids capable detecting known unknown attacks near real time low false positive rate supervised approaches intrusion detection provides good detection accuracy known attacks detect unknown attacks existing nids emphasize unknown attack detection using unsupervised anomaly detection techniques distinguish network data accurately supervised approaches moreover consider important issues like real time detection minimization false alarm overcome problems recent years many hybrid nids proposed basically aimed detecting known unknown attacks high accuracy detection literature review hybrid network intrusion detection systems discuss notable hybrid nids proposed recent years try provide comparative study
increasing prevalence electronic readers readers vocational professional uses important discover visual consequences use products studies literature quantifying incidence severity eyestrain clinical characteristics may predispose symptoms reader use primary objective pilot study assess degree eyestrain associated reader use compared traditional paper format secondary outcomes study assess rate eyestrain associated reader use identify clinical characteristics may associated development eyestrain forty four students randomly assigned study reader ipad control print groups participant posture luminosity room reading distance reading device measured session groups end session questionnaires administered determine symptoms significantly higher rates eyestrain irritation found among ipad study group compared print control group study group also times likely report severe eyestrain clinical characteristics predisposing eyestrain could identified findings conclude reading readers may induce increased levels irritation eyestrain predisposing factors etiology potential remedial interventions remain determined
increasing proportion natural gas power generation natural gas network electricity network closely coupled therefore planning individual system regardless interdependence increase total cost whole combined systems therefore multi objective optimization model combined gas electricity network planning presented work specific objectives proposed model minimize investment cost production cost combined system taking account network security criterion moreover stochastic nature wind power generation addressed proposed model consequently leads mixed integer non linear multi objective stochastic programming problem solve complex model elitist non dominated sorting genetic algorithm nsga employed capture optimal pareto front wherein primal dual interior point pdip method combined point estimate method adopted evaluate objective functions addition decision makers use fuzzy decision making approach based preference select final optimal solution optimal pareto front effectiveness proposed model method validated modified ieee bus electricity network integrated node natural gas system well real world system hainan province authors published elsevier ltd
increasing sizes digital elevation models dems growing need design parallel schemes existing sequential algorithms identify fill depressions raster dems priority flood algorithm fastest sequential algorithm literature depression identification filling raster dems parallel implementation since proposed approximately decade ago parallel priority flood algorithm based fastest sequential variant proposed study algorithm partitions dem stripes processes stripe using sequential variant many rounds progressively identifies slope cells misidentified depression cells previous rounds open multi processing openmp message passing interface mpi based implementations presented speed ratios openmp based implementation sequential algorithm greater four tested dems eight computing threads mean speed ratio mpi based implementation greater eight taudem widely used mpi based library hydrologic information extraction speed ratios mpi based implementation generally become larger computing nodes study shows priority flood algorithm implemented parallel makes ideal algorithm depression identification filling single computers computer clusters
increasingly serious environmental problems energy saving environmental protection green building began people attention gradually become development trend future building came green building integrated design apply integrated design theory green building concrete architectural design practice question designers must seriously think paper expounds integrated design concept green building integration methods connotation green building design puts forward integrated design strategy green building design concept theory practical application order provide reference designers managers
installation synchrophasors widely across power grid measurement based oscillation monitoring algorithms becoming increasingly useful identifying real time oscillatory modal properties power systems number phasor measurement unit pmu channels grows computational time many pmu data based algorithms dominated computational burden processing large scale dense matrices order overcome limitation paper presents new formulations computational strategies speeding ambient oscillation monitoring algorithm namely stochastic subspace identification ssi based previous work two fast singular value decomposition svd approaches first applied svd evaluation within ssi algorithm next block structures exploited large scale dense matrix computations processed parallel helps memory savings well computational time experimental results three sets archived data western interconnection demonstrate new approaches provide significant speedups retaining modal estimation accuracy proposed fast parallel algorithms real time oscillation monitoring large scale system using hundreds pmu measurements becomes feasible
introduction electrified drive trains autonomous driving features requirements electronic systems vehicles rapidly become demanding order face complex requirement scenarios paradigm shift closed loop controlled truly self deciding self learning automata strongly needed paper novel concept drive train platforms enabling self learning capabilities based sensor integration micro power electronics secure cloud communication directly integrated electric motor introduced
popular use high resolution satellite images research efforts focused land use scene classification scene classification effective visual features significantly boost final performance typical texture descriptor census transform histogram centrist emerged powerful tool due effective representation ability however prominent limitation centrist small spatial support area may necessarily adept capturing key texture characteristics propose extended centrist ecentrist made three subschemes greater neighborhood scale proposed ecentrist inherits advantages centrist also encodes useful information local structures meanwhile multichannel ecentrist capture interactions multichannel images developed obtain higher categorization accuracy rates experimental results demonstrate proposed method achieve competitive performance compared state art methods society photo optical instrumentation engineers spie
rapid advancement wireless technologies distinct futuristic applications wireless sensor networks wsns evolving public private domains however wireless sensor nodes experience major challenges terms power supply computing capabilities bandwidth requirements data communication apart data confidentiality integrity suffer due various transmission errors caused channel noise channel bandwidth limitation weak signals limitation transmitting receiving devices well different security attacks various researches conducted resolve issues integrated way nevertheless existing literature offer effective solution resolve issues hence paper proposes unique elliptic curve based cryptography along diffie hellman key exchange technique address issues experimental results show proposed technique consumes low power utilizes cpu time effectively offering better throughput low cyclomatic complexity enhances confidentiality producing higher avalanche effect entropy value existing techniques capacity generating higher signal noise ratio lower percentage information loss justify efficiency produce higher data integrity compared existing schemes literature
rapid advances field computer vision systems increasing flexibility using multimedia applications brings major challenges terms algorithm design hardware one widely used infotainment application smart control multimedia portfolio paper presents non intrusive approach smart control virtual assistance system targeting elderly citizens using stereo vision switching volume inr decr events without using hand held remote control system initialized waving hands view stereo vision mounted television hand palm regions detected extracted using motion color space model next successive frames video hand palms tracked using color histogram based tracker virtual plane constructed waving hand palms around view stereo vision camera reconstructing points using epipolar geometry triangulation key press release events identified measuring distance projected forefinger tip onto virtual plane volume incr decr events identified waving hands view stereo vision
rapid development embedded system internet things technology embedded system smart device based embedded system collecting huge amounts data corresponding data processing application method greatly changed different traditional big data cloud computing focus local processing application become important trend paper tries take cortex main system stronger ability hadoop distributed computing system deployed embedded system could meet demand future data process directly managing resource constrained sensors embedded systems smart devices successfully deploying data test system verified complete functions data processing cluster also manage collected sensors embedded system terminal better research market promotional value
rapid development mobile internet people pay increasing attention wireless network security problem due specificity wireless network present rare see research wireless intrusion alerts clustering method mobile internet paper proposes wireless intrusion alert clustering method wiacm based information mobile terminal method includes alert formatting alert reduction alert classification introducing key information mobile terminal device method aggregates original alerts hyper alerts experimental results show wiacm would appropriate real attack scenarios mobile internet reduce amount alerts accuracy alert analysis
rapid development science technology network popularization computer network security becomes social problem based analysis main factors influencing computer network security risk evaluation index system computer network security established analytic hierarchy process ahp used calculate weight index common criteria determine grey clustering computer network security risk establishing whitenization weight function computer network security risk evaluation model calculating whitenization clustering coefficient clustering vector computer network security risk evaluation model evaluation results finally obtained method scientific reasonable combining subjective evaluation objective calculation
rapid technological development various satellite sensors high resolution remotely sensed imagery important source data change detection land cover transition however still challenging problem effectively exploit available spectral information highlight changes paper present novel change detection framework high resolution remote sensing images incorporates superpixel based change feature extraction hierarchical difference representation learning neural networks first highly homogenous compact image superpixels generated using superpixel segmentation makes image blocks adhere well image boundaries second change features extracted represent difference information using spectrum texture spatial features corresponding superpixels third motivated fact deep neural network ability learn data sets labeled data use learn semantic difference changed unchanged pixels labeled data selected bitemporal multispectral images via preclassification map generated advance neural network built learn difference classify uncertain samples changed unchanged ones finally robust high contrast change detection result obtained network experimental results real data sets demonstrate effectiveness feasibility superiority proposed technique
rise restrictions imposed law gases emission several technologies petrodiesel diesel engines applied sulfur reduction injection electronic command followed gases recirculation treatment utilization biofuels considered interesting option pollutants reduction study evaluated performance short duration tests minor period factory indication lubricant lifespan diesel engine fueled four vegetable oils aim select interesting oils future evaluations long duration tests analyzed variables fuel consumption power relative loss opacity oils linseed crambe rapseed jatropha degrees preheating engine work temperature degrees comparing verified vegetable oils average present lower consumption cases working without load however load presented higher consumption addiction observed oils show higher relative power loss relation provides lower emission particulate matter crambe canola presented best performance among evaluated oils
uptake distance learning actually marginal academics teaching contexts traditional power structures relationships transformed leaving lecturers potentially disenfranchised institutional cultural change vital particularly changes concerning academic roles advent caused role ambiguity however published literature related academic roles confusing lacks clear guidance academics involved post graduate clinical education information even incomplete using framework communities study direct response concerns aim systematically critically evaluate implementation clinical effort improve practice maintaining practitioner inquiry methodology study investigated development delivery new module data collection consisted documentary analysis meetings interviews staff students student evaluations analytics data analysis incorporated quantitative qualitative methods triangulate research findings new competencies academics emerged including leadership management barriers staff progress included ambiguity roles lack leadership unpreparedness responsibilities time workload student barriers included time fear relevance learning isolation increased autonomy explicit planning organisational support working within communities requisite create sustaining technology study contributes educational practice two levels firstly striving rigour demonstrates practitioner inquiry legitimate research approach accessible valuable teachers secondly adds useful applied knowledge concerning practice avoiding traditional workload assumptions erroneous inaccurate study provides new models organisational roles responsibilities results challenge evolutionary nature academia suggesting working communities new competencies required whilst traditional roles culture must redefined
within comparative school effectiveness research facilitated large scale data across countries article presents results testing measurement invariance latent concept professional community across european countries teachers secondary schools newly proposed multiple group factor analysis alignment method applied obtain mean differences latent factor also identifying non invariant parameters different countries performing number robustness checks including multiple group confirmatory factor analysis mgcfa exact scalar method conclude teachers eastern european countries report highest average perceived practices countries smaller mean differences tend shift places ranking methods applied however changes among groups significant latent mean differences observed
within education concepts distance learning open universities becoming widely used teaching learning however due nature subject domain teaching science technology engineering still relatively behind using new technological approaches particularly online distance learning reason discrepancy lies fact fields often require laboratory exercises provide effective skill acquisition hands experience often difficult make laboratories accessible online access either real lab needs enabled remote access needs replicated fully software based virtual lab argue latter concept since offers advantages remotely controlled real labs elaborated paper seeing new emerging technologies overcome potential difficulties area include computer graphics augmented reality computational dynamics virtual worlds paper summarizes state art virtual laboratories virtual worlds fields science technology engineering main research activity fields discussed special emphasis put field robotics due maturity area within virtual education community coincidence starting widely multidisciplinary character robotics perfect example fields engineering physics contribute thus use virtual labs scientific non robotic engineering uses seen share many learning processes include supporting introduction new concepts part learning science technology introducing general engineering knowledge supporting constructive collaborative education training activities complex engineering topic robotics objective paper outline problem space detail create valuable source information help define starting position future research elsevier ltd rights reserved
within early late start typology offenders schizophrenia third type first offenders proposed aim study examine justification first offender type retrospective file study consisted early starters late starters variables different domains scored significant differences groups within domains life functioning abuse family related problems psychiatric functioning substance misuse antisocial personality offense characteristics differences existence first offender type justified present findings findings underscore importance offender subtyping better offender treatment interventions
women globally underrepresented energy industry paper reviews existing academic practitioner literature women employment renewable energy industrialized nations emerging economies developing countries highlights similarities differences occupational patterns women employment renewables different parts world makes recommendations optimizing women participation findings reveal need broader socially progressive policies shifts societal attitudes gender roles order women benefit optimally employment renewables industrialized countries restructuring paid employment innovative ways unlinking social protection employment status suggested way balance gender equity economic security environmental protection however without transformative social changes gender relations strategies may simply reinforce rather subvert existing gender inequities paid employment unpaid domestic labor grounded interventions promote gender equality renewable energy employment especially within context increasing access energy services underserved communities prevalent better established non oecd organisation economic operation development countries oecd countries might well advised try implement certain programs policies already place emerging economies
women bear predominant burden obesogenic environment higher incidence obesity men impact fertility success treatment significant maternal perinatal morbidity mortality series causes consequences solutions regarding obesity pandemic mechanisms effect obesity female male epigenetic consequences male obesity marked effects perinatal outcomes effects weight loss conception pregnancy explored lifestyle modifications particular healthy diet exercise months conception treatment result better outcomes requiring weight loss fertility treatments fundamental changes toward healthier lifestyle achieve steady sustainable weight loss long term benefits general health role bariatric surgery pregnancy requires careful consideration american society reproductive medicine
word problems prevalent high stakes assessments success word problems implications grade promotion graduation unfortunately english language learners ells continue perform significantly native english speaking peers mathematics assessments featuring word problems little known instructional needs performance ells risk mathematics difficulty present study exploratory quasi experimental design used investigate word problem instruction ells culturally linguistically diverse public elementary school specifically studied efficacy word problem intervention ells combined culturally linguistically responsive practices schema instruction clr study unique combines research effective instruction ells students clr investigated either ells students results implications teachers administrators researchers ells
words activate cortical regions accordance modality presentation written spoken yet long standing debate whether patterns activity specific brain region capture modality invariant conceptual information deficits patients semantic dementia highlight anterior temporal lobe atl amodal store semantic knowledge studies permit precise localisation function current investigation used multiple imaging methods healthy participants examine functional dissociations within atl multi voxel pattern analysis identified spatially segregated regions response input modality anterior superior temporal gyrus astg response meaning ventral anterior temporal lobe vatl functional dissociation supported resting state connectivity found greater coupling astg primary auditory cortex vatl default mode network meta analytic decoding connectivity patterns implicated astg processes closely tied auditory processing phonology language vatl meaning based tasks comprehension social cognition thus provide converging evidence segregation meaning input modality atl
work paper presents results field testing four instrumented roadway sections constructed poor subgrade soils stabilized select fill geosynthetics cement loading applied using consecutive truck passes profile surveying performed provide permanent deformation rutting data peak vertical stresses subgrade well moisture conditions also monitored testing results indicated deep undercut select material backfill section produced largest cumulative rut depths due shallow incremental plastic strains induced axle pass use thin aggregate base course abc surface layer select material reduced rate rutting biaxial geogrid high strength geotextile showed relatively equal performance aspects study cement stabilized section produced slightly larger average rut depth geosynthetically reinforced sections due localized areas pronounced cumulative rutting however several areas soil cement test section performed well geosynthetically reinforced sections
work related stress construction management trigger impairment employees psychological health thus affect project performance psychological disorders deleterious consequences project performance received sufficient attention literature study aims identify different types psychological disorders construction projects develop fuzzy mapping determine impact psychological disorders context time cost quality construction management questionnaire survey assisted pair wise comparison among experienced construction personnel six common psychological disorders including depression generalized anxiety disorders gad obsessive compulsive disorders ocd substance use disorders sud acrophobia claustrophobia analyzed using principal component analysis pca partial least square pls tests fuzzy analytic hierarchy process fuzzy ahp followed visualization although various stressors work overload role ambiguity conflict unpaid overtime restrictive career progression diverse range personalities common construction management different roles positions subjected different levels stress high low project manager civil engineer architect contractor quantity surveyor mechanical electrical engineer research developed fuzzy mapping psychological disorders context project performance useful project management teams reveal tackle mental health problems early stages american society civil engineers
worldwide pregnancies unintended widespread counter availability oral emergency contraception reduced unintended pregnancy rates visit presents opportunity initiate highly effective method contraception population high risk unintended pregnancy actively seeking avoid pregnancy copper intrauterine device iud effective method continues provide contraception effective sterilization years offered first line method wherever possible increased demand supply copper iud may important role reducing rates unintended pregnancy visit include access copper iud optimal care ideally include access highly effective methods contraception
worldwide ecosystem change compromises supply ecosystem services better managing ecosystems requires detailed information changes implications supply ecosystem accounting developed environmental economic accounting system using concepts aligned system national accounts ecosystem accounting requires spatial information local national scale objective paper explore remote sensing used analyze ecosystems using accounting approach orinoco river basin assessed ecosystem assets terms extent condition capacity supply focus four specific grasslands grazed cattle timber harvesting oil palm fresh fruit bunches harvesting carbon sequestration link six ecosystem assets savannahs woody grasslands mixed agroecosystems dense forests dense forest oil palm plantations used remote sensing vegetation productivity indexes measure ecosystem assets found remote sensing powerful tool estimate ecosystem extent enhanced vegetation index used assess ecosystems condition net primary productivity used assessment ecosystem assets capacity supply integrating remote sensing ecological information facilitates efficient monitoring ecosystem assets society photo optical instrumentation engineers spie
worrying key concept describing complex relationship anxiety cognitive control one hand cognitive control processes might underlie specific tendency engage worrying trait worry conceptualized future oriented mental problem solving activity hand general tendency experience signs symptoms anxiety trait anxiety suggested impair cognitive control worrisome thoughts interfere task relevant processing based opposing tendencies predicted effect two related constructs trait anxiety trait worry might cancel one another statistics instances termed suppressor situations four experiments found evidence suppressor situation shared variance controlled trait worry positively whereas trait anxiety negatively related performance memory task requiring strategic effortful retrieval also showed opposing effects related temporal context reinstatement results suggest trait worry trait anxiety possess unique sources variance differently relate performance memory tasks requiring cognitive control
wound dressings play important role patient recovery health problems unattended wounds could lead serious complications infections ultimately even death therefore wound dressings since ancient times continuously developed starting simple dressings natural materials covering wounds modern dressings functionalized materials aid wound healing process enhance tissue repair however understanding nature wound subsequent healing process vital information upon dressings tailored ensure patient recovery date much progress made use nanomedicine wound healing due ability materials mimic natural dimensions tissue review provides overview recent studies physiology wound healing various wound dressing materials made nanofibers fabricated using electrospinning technique
writing highly performant simulations requires lot human effort optimize increasingly diverse set hardware platforms multi core cpus gpus distributed machines since optimizations cut across design geometric data structures numerical linear algebra code reusability portability frequently sacrificed performance believe key make simulation programmers productive developing portable performant code introduce new linguistic abstractions rendering image processing perspective distill core ideas two languages ebb simit published journal
yield stress fluid flows occur great many operations unit processes within oil gas industry paper reviews usage within reservoir flows heavy oil drilling fluids operations wellbore cementing hydraulic fracturing open hole completions sealing remedial operations squeeze cementing lost circulation waxy crude oils flow assurance wax deposition restart issues outline rheological aspects relevant fluid mechanics issues focusing primarily yield stress fluids related phenomena
young gay bisexual men increased risk human immunodeficiency virus hiv infection research suggests stress associated stigmatized minority related negative mental health outcomes substance use condomless sex however interventions aimed reducing hiv risk behaviors young gay bisexual men failed address important variables purpose present paper assist cognitive behavioral therapists work young gay bisexual men conduct therapy stress management hiv prevention paper provides overview research stress coping among gay bisexual men relation condomless sex among young gay bisexual men treatment described integrates minority stress theory meyer stress coping theory lazarus small group counseling framework uses psychoeducation cognitive reframing role plays help young gay bisexual men manage stress reduce substance use reduce condomless sex application empirically supported theory combination cognitive behavioral techniques reduce psychological distress hiv risk behavior young gay bisexual men illustrated using three case examples present treatment may help therapists working young hiv negative gay bisexual men engage condomless sex wish remain hiv negative decreasing hiv risk behavior
youth ageing child welfare system become parents rates two three times higher non child welfare system involved peers substantial literature acknowledges youth ageing parenting vulnerable yet little known lived experiences social capital actual potential resources available one network provide essential resources wellbeing parents ageing qualitative study examined social capital mothers ageing perspectives mothers service providers conducted small group interviews mothers ageing service providers data analysed using thematic analysis findings revealed use social capital framework delineates mothers lacked beneficial social relationships consequently support lack trust coupled desire break intergenerational patterns norms contributed understanding mothers ageing may capitalize resources providers often considered available based findings conclude providing mothers ageing additional opportunities develop trust positive relationships mentors extended services may help disrupt intergenerational patterns maltreatment promote child family wellbeing
zero attracting least mean square lms algorithm widely used online sparse system identification combines lms framework norm regularization promote sparsity relies subgradient iterations despite significant interest lms works analyzed transient behavior main difficulty lies nonlinearity update rule study detailed analysis mean mean square sense carried order examine behavior algorithm simulation results illustrate accuracy model highlight performance comparisons existing model
zika virus emerging mosquito borne aedes genus arbovirus flaviviridae family following epidemics micronesia french polynesia past decade recent zika virus infection outbreaks first reported south america early may spread countries throughout americas although flavivirus previously known cause major fetal malformations following perinatal infection reports causal link zika virus microcephaly brain ocular malformations fetal loss emerged hard hit regions brazil october among minority infected women symptoms clinical manifestations zika virus infection may include fever headache arthralgia myalgia maculopapular rash however every people infected symptoms thus clinical symptom reporting ineffective screening tool relative risk assessment zika virus infection majority patients previously occurred largely asymptomatic viral infections posing perinatal transmission risk hiv cytomegalovirus must develop implement rapid sensitive specific screening diagnostic testing viral detection estimation timing exposure unfortunately despite unprecedented surge attempts rapidly advance perinatal clinical testing previously obscure arbovirus several ongoing hindrances molecular sonographic based screening diagnosis congenital zika virus infection include following difficulty estimating timing exposure women living endemic areas thus limited interpretability immunoglobulin serologies cross reaction immunoglobulin serologies endemic flaviruses dengue persistent viremia viruria pregnancy weeks months primary exposure fetal brain malformations anomalies preceding sonographic detection microcephaly commentary discuss screening diagnostic considerations grounded realities current obstetrical practice largely global population also basic immunology virology review recent epidemiological data pertaining risk congenital zika virus malformations based trimester exposure consider side side emerging data demonstrating replication zika virus placental fetal tissue throughout gestation discuss limitations ultrasound based strategies rely largely solely detection microcephaly provide alternative neurosonographic approaches detection malformations may precede occur independent small head circumference expert review provides information value following obstetrician maternal fetal medicine specialist midwife patient family cases suspected zika virus infection review methodology laboratory testing explore presence virus immune response ultrasound based assessment fetus suspected exposed zika virus particular emphasis central nervous system identification areas ready development
zusammenfassung hintergrund karate erfreut sich sowohl profi als auch breitensport gro beliebtheit die einteilung der verschiedenen stilrichtungen erfolgt anhand des impacts voll halb und lowkontakt ziel dieser arbeit war die analyse von sportverletzungen kyokushinkai vollkontakt und traditionellem karate semikontakt methoden rahmen einer querschnittsbefragung wurden insgesamt aktive amateurkarateka vollkontakt und semikontaktkarateka mittels eines standardisierten fragebogens nach sportarttypischen verletzungen der letzten monate befragt die verletzungen wurden nach verletzungsschwere vier gruppen unterteilt schweregrad bedeutete dass keine arztliche behandlung erfolgte schweregrad beinhaltete eine einmalige arztliche behandlung schweregrad iii eine mehrfache ambulante medizinische behandlung und bei schweregrad erfolgte eine stationare behandlung ergebnisse verletzungen wurden einzelnen beschrieben wobei verletzungen bei vollkontakt und verletzungen bei semikontaktkarateka auftraten ergab sich eine expositionszeitbezogene verletzungsrate von stunden fur vollkontakt und stunden fur semikontaktkarateka die haufigsten verletzungsarten waren muskuloskelettale kontusionen vollkontaktkarate semikontaktkarate gefolgt von distorsionen mit bzw die untere extremitat war bei den vollkontaktkarateka mit doppelt haufig betroffen wie bei semikontaktkarateka der vollkontakt und der semikontaktkarateka gaben sich wahrend des trainings verletzt haben sowohl training als auch wettkampf kam beim kumite freikampf den meisten verletzungen der verletzungen bei vollkontakt und bei semikontaktkarateka entfielen auf leichte verletzungen grad oder schlussfolgerung die hohe verletzungsrate training und kumite freikampf weist auf spezifische praventionsziele hin hier sollte verstarkt auf propriozeptives training und auf ein konsequentes aufwarmen wert gelegt werden zur pravention wettkampf selbst kommt den schiedsrichtern eine wichtige aufgabe abstract background karate enjoys great popularity professional recreational sports classified full half low contact styles aim study analysis sports injuries kyokushinkai full contact traditional karate semi contact methods retrospective study design active amateur karateka full contact semi contact interviewed means standardised questionnaire regarding typical sport injuries last months injuries categorised severity grade requiring medical treatment grade single medical treatment grade iii several outpatient medical treatments grade requiring hospitalisation results total injuries reported detail injuries occurred full contact semi contact karate time related injury rate full contact karateka compared semi contact karateka common types injuries musculoskeletal contusions full contact semi contact followed articular sprains lower extremity affected twice often full contact semi contact karate training injuries reported full contact semi contact karateka injuries training competition occurred kumite reported injuries full contact semi contact karateka classified low grade conclusion high rate injuries training kumite sparring points specific prevention goals emphasis put proprioceptive training consistent warm actual competition referees play vital role regarding prevention
municipal infrastructure water supply delivery often reach populations rural peri urban areas article examines rainwater harvesting means increasing water security areas case guachtuq peri urban community outside san cristobal alta verapaz guatemala project team designed rainwater harvesting system improve three dimensions water security quantity quality access design implemented households evaluated contribution water security potential expanding project coverage region beyond system improved water security several concerns remain however regarding potential expanding project households region beyond including system cost water quality individualization public responsibility water security
although hyperglycemia common neonates especially preterm infants diagnosis neonatal diabetes mellitus ndm rarely made ndm permanent transient syndromic identifiable mutations ndm methylation defects kcnj abcc ins account majority two cases transient ndm extremely preterm weeks gestational age triplets due missense mutation kcnj gene presented patients successfully transitioned insulin glyburide glibenclamide months age comprehensive genetic testing targeted next generation sequencing methylation analysis helps identify monogenic diabetes early thereby improving metabolic glycemic control patients potassium channel mutations started sulfonylurea treatment
multiple sclerosis inflammatory demyelinating autoimmune disorder central nervous system cns associated severe neurological disability reactive oxygen species ros mitochondrial dysfunction play pivotal role pathogenesis disease several members mitochondrial uncoupling protein subfamily ucp ucp suggested regulate ros diminishing mitochondrial membrane potential constitute therefore promising pharmacological target evaluate role different uncoupling proteins neuroinflammation investigated expression patterns murine brain spinal cord different stages experimental autoimmune encephalomyelitis eae animal model mrna protein levels found ucp regulated brain increase ucp expression antigen independent reached maximum days ova mog immunized animals correlated augmented number lymphocytes parenchyma decrease abundance ucp due neuronal injury detected cns mog induced eae animals results provide evidence involvement mitochondrial ucp cns inflammation eae may mainly explained invasion activated lymphocytes conclusion coincides previous observation ucp regulated activated rapidly proliferating cells participates fast metabolic programming cells proliferation elsevier rights reserved
background study aimed investigate central auditory processing performance children migraine compared controls without headache methods twenty eight children sexes aged years diagnosed migraine without aura control group age range headache history included gaps noise gin duration pattern test dpt synthetic sentence identification ssi test nonverbal dichotic test nvdt used assess central auditory processing performance results children migraine performed significantly worse dpt ssi test nvdt compared controls without headache however significant differences found gin test conclusions children migraine demonstrate impairment physiologic mechanism temporal processing selective auditory attention short communication migraine could related impaired central auditory processing children
task force experts convened american psychological association apa update knowledge policy impact violent video game use potential adverse outcomes apa task force media violence examined existing literature including meta analyses field since last apa report media violence recent meta analyses published reflected work task force conducted search published studies recently published articles scored assessed systematic evidentiary review followed meta analysis high utility studies documented evidentiary review consistent literature reviewed found violent video game exposure associated increased composite aggression score increased aggressive behavior increased aggressive cognitions increased aggressive affect increased desensitization decreased empathy increased physiological arousal size effects similar prior meta analyses suggesting stable result task force concluded violent video game use risk factor adverse outcomes found insufficient studies examine potential link violent video game use delinquency criminal behavior technical report basis article
mott insulating oxides heterostructures recently identified potential photovoltaic materials favorable absorption properties intrinsic built electric field efficiently separate excited electron hole pairs time predicted overcome shockley queisser limit due strong electron electron interaction present despite premises high concentration defects commonly observed mott insulating films acting recombination centers derogate photovoltaic conversion efficiency use self regulated growth kinetics hybrid molecular beam epitaxy obstacle overcome high quality stoichiometric lavo films grown defect densities gap states orders magnitude lower compared films literature factor lower lavo bulk single crystals photoconductivity measurements revealed significant photoresponsivity increase high tenfold stoichiometric lavo films compared nonstoichiometric counterparts work marks critical step toward realization high performance mott insulator solar cells beyond conventional semiconductors
increasing rates cancer patients undergoing radiation therapy treatment cause patients significant amounts anxiety distress attributed diagnosis disease lack knowledge radiation therapy expectations management side effects lack knowledge supportive care patients families providing patients effective educational tools meet informational needs cancer patients undergoing radiation therapy empower patients allow participate treatment decision making healthcare discussion paper evaluate several studies psychological impact cancer patients undergoing radiation therapy video material effectively meet informational educational needs patient population group
high resolution non hydrostatic global mesoscale simulation using goddard earth observing system geos model used visualize flow fluxes carbon dioxide throughout year carbon dioxide important greenhouse gas affected human activity half emitted fossil fuel combustion remains atmosphere contributing rising temperatures half absorbed natural land ocean carbon reservoirs despite importance many questions remain regarding processes control fluxes may change response changing climate visualization shows column mixing ratios strongly affected local emissions large scale weather systems order fully understand carbon flux processes observations atmospheric models must work closely together determine observed came together combination high resolution data models guide climate models towards reliable predictions future conditions published elsevier
high speed folded cascode amplifier dynamic switching bias circuit enables low power consumption high gain stably relatively wide dynamic range low power supply voltages proposed simulations shown amplifier able operate mhz dynamic switching rate dissipated power observed continuous operation also showed open loop gain output dynamic range wider telescopic amplifier mhz high speed switching operation allowing processing video signals confirmed applying switched capacitor non inverting amplifier gain simulation results showed output inaccuracy switched capacitor amplifier gain practicable inaccuracy caused static nonlinearity amplifier determined limited open loop gain
aircrafts employing stealth technology acclimatizes enemy hostile environment invisible enemy detection system though stealth technologies different kinds technology involved body designing aircraft forms foremost preferred method body designing involves alteration body surfaces form inclinations edges causing uneven area make incident electromagnetic wave radar scatter multi direction object reduces intensity reflected wave moving towards source receiver improvising surface reduce intensity reflected wave towards receiver lessen radar cross section plane lesser radar cross section aircraft less detectable enemy radar paper presents experimental results fabricated object different angles antenna along explanation uncertain behaviour reflected wave fabricated object result related radar cross section object
norway experienced internet voting municipal parliamentary elections respectively security depends assumptions involving organizations completely independent reliable receipt codes securely sent voters paper point following aspects vote privacy norwegian scheme violated ballot box receipt generator cooperate private key decryption service obtained two former players propose solution avoid issue without adding new players assure correctness receipt codes sent voters pre channel postal service post channel short message service sms however holding sms postal receipt code voter reveal vote even elections albeit revoting fairly well solution coercion concealment intentional vote revealing still problem suggest sms notification vote submission case codes falsely generated pre channel secure vote counted different candidate without detection propose solution voters verify integrity postal receipt codes copyright john wiley sons ltd
understanding human mind idioms human distress mental health improved become apparent culture impact aspects lives including mental illness systems care across globe need adapt adjust delivery care order accommodate impact globalisation therefore able deliver person centred care key aspect delivering personalised care development delivery culturally adapted interventions benefit cultural minority groups developed countries majority cultural groups developing countries journey acknowledging need culturally relevant services begun long way delivering personalised care people deserve paper makes case action important area
maintaining satisfactory properties geosynthetics exposed factors could lead degradation needs considered projects employing materials geosynthetics subjected tensile creep weathering undergo premature degradation time essential study influence factors since could act simultaneously applications assess synergetic effects frames developed four groups woven geotextile polypropylene sample tested first second groups subjected tensile creep tensile strength conjunction weathering third group exposed weathering conditions without tensile load fourth group subjected tensile creep tensile strength laboratory conditions frames built slope similar location exposure guarantee greater effects weathering material surface meteorological station site monitored meteorological parameters degradation suffered geotextile determined comparing tensile strength test results results presented show importance constructed frames assesssing tensile creep weathering field small loads
objectives purpose conduct systematic review published articles aiming prevent sports injuries based psychological interventions perform meta analysis effects interventions news different kinds sport injury prevention strategies accomplished neuromuscular warm programs recently psychological intervention studies completed purpose preventing sports injuries evident predictor stress consequently psychological injury prevention interventions incorporate stress management psychological skills training prospect projects electronic databases suitable sport psychology journals searched published studies screened articles potentially eligible articles seven articles substantial information papers authors able provide data request finally included conclusion result using random effect model showed total hedges effect size result indicates psychological injury prevention interventions large effect reducing number injuries sport population elsevier masson sas rights reserved
objectives study aimed assess head neck cancer patient satisfaction use touch screen computer patient completed questionnaire assessing adult morbidity evaluation morbidity scores prior treatment along clinical reliability methods total head neck cancer patients included audit accurate adult morbidity evaluation morbidity score achieved via patient completed questionnaire assessment per cent participants results per cent patients found use touch screen computer acceptable would willing use one per cent would willing without help patients likely willing use computer without help aged years younger test performance status test conclusion use touch screen computer acceptable approach assessing adult morbidity evaluation scores pre treatment assessment multidisciplinary joint surgical oncology clinic
paper presents design approach interior permanent magnet ipm machines variable flux characteristics using low coercive force magnets improved efficiency extended operating speed range flux intensifying ipm type used design due positive operation reduced loaded effects design considerations machine structures variable flux machine attributes discussed addition leakage flux rotor particularly designed also obtain another flux varying capability evaluation designed machine provided finite element analysis simulations experiments proof principle machine designed machine shows benefits increasing efficiency speed range low torque region variable magnetization control low coercive force magnets design leakage flux proposed paper implemented
paper bifurcation analysis well sub equation expansion method applied study extended dimensional konopelchenko dubrovsky equations bifurcation analysis first used obtain existence traveling wave solutions via sub equation expansion method new solitary like wave solutions parameter condition obtained
modeling scientific engineering applications often yields high dimensional dynamical systems due techniques computer aided design example thus model order reduction required decrease dimensionality enable efficient numerical simulation addition methods parameterized model order reduction pmor often used preserve physical geometric parameters independent variables reduced order models consider linear dynamical systems form ordinary differential equations domain parameters often samples chosen construct reduced order model sample point common technique model order reduction applied compute local basis moment matching balanced truncation feasible example global basis pmor constructed local bases singular value decomposition investigate approaches appropriate selection finite set samples transfer function dynamical system examined frequency domain focus moment matching techniques using arnoldi procedure use sensitivity analysis transfer function respect parameters tool select sample points simulation results shown two examples elsevier rights reserved
work study localization properties disordered classical dual transmission lines values capacitances inductances fluctuate phase form sin sin fluctuation amplitude disordered long range correlated sequence obtained using fourier filtering method depends correlation exponent alpha obtain transition point thermodynamic limit study critical behavior participation number calculate linear relationship versus relative fluctuation eta binder cumulant critical value obtained three methods totally coincident addition calculate critical behavior normalized localization length lambda function system size data build phase diagram alpha separates extended states localized states final result work disappearance conduction bands introduce finite number impurities random sites process serve mechanism secure communication since little alteration original sequence capacitances inductances destroy band extended states elsevier rights reserved
increasing evidence shown diabetes associated cognitive impairment correlated mitochondrial dysfunction resultant synaptic injury well brain insulin resistance cardiotrophin regulator energy metabolism shown exhibit impressive neuroprotective effects study evaluated effects brain pathological features intracerebroventrical streptozotocin icv stz treated mouse model explored potential mechanisms stz injected twice icv alternate days day day mice daily treatment day icv starting first dose stz days showed significantly improved learning memory deficits alleviated mitochondrial dysfunction increased synaptic density region hippocampus icv stz treated mice moreover significantly enhanced insulin signaling pathway hippocampus icv stz treated mice compared control however protective effects including biochemistry pathological changes cognitive function could blocked icv injection compound specific ampk inhibitor taken together results suggested improves pathological changes cognitive impairments via ampk activation icv stz mice elsevier inc rights reserved
study basic idea multi signal flow graph modeling method summary analyzed specific ways build multi signal model determined multi signal model built typical subsystem satellite real time fault diagnosis based multi signal deeply studied basis analysis capacity needs real time fault diagnosis satellite systems algorithm basic teams distributed fault diagnosis investigated
lettuce aphid nasonovia ribisnigri mosley economically important pest lettuce worldwide recently entomopathogenic fungus beauveria bassiana strain gha aphelinid parasitoid aphelinus abdominalis dalman reported potential biological control candidates use ribisnigri however information available interaction bassiana abdominalis applied study therefore examined compatibility bassiana abdominalis laboratory experiments specifically assessed susceptibility two abdominalis developmental stages larvae pupae two spore concentrations bassiana high low conidia control tween found parasitoid larvae highly susceptible infection high spore concentration bassiana measured rates mummy formation mean adult emergence mean compared control treatment mummification mean adult emergence mean contrast bassiana effects parasitoid development parasitoid larvae treated lower spore concentration parasitoid pupae treated either high low spore concentrations study suggests might possible combine bassiana abdominalis integrated pest management ribisnigri application bassiana timed coincide presence advanced developmental stages abdominalis protect parasitoid another option would delay release abdominalis bassiana application abdominalis longer susceptible fungal infection
risk hepatitis virus hbv reactivation hbvr chronic hbv carriers occult hbv patients acute hbv patients affected psoriasis treated antitumor necrosis factor tnf alpha agents clinical practice issue face particularly treatment long term maintenance finality aims review examine current knowledge hbvr incidence chronic hbv carriers potential occult carriers undergoing therapy biologics treatment psoriasis psoriatic arthritis analyze prophylactic measure prevent hbv reactivation define manage hbvr patients treated biologics searched pubmed google scholar scopus databases evaluated published manuscripts concerning hbvr psoriatic patients plaquetype psoriatic arthritis treatment indicated anti tnf alpha although anti tnfs considered moderate immunosuppressive drugs incidence hbvr psoriatic patients lower compared patients affected immune mediated diseases treated tnf inhibitors hbv prophylaxis probably reserved anti hbs anti hbc patients viral load alterations serum liver enzymes order prevent hbvr
significant challenge electric vehicles multiple motors control individual drivetrains order achieve measurable benefits terms vehicle cornering response compared conventional stability control systems actuating friction brakes paper presents direct yaw moment controller based combination feedforward feedback contributions continuous yaw rate control estimated sideslip exceeds pre defined threshold sideslip based yaw moment contribution activated yaw moment contributions entirely tunable model based approaches reduced vehicle testing time purpose controller continuously modify vehicle understeer characteristic quasi static conditions increase yaw sideslip damping transients skid pad step steer sweep steer tests carried front wheel drive fully electric vehicle demonstrator two independent drivetrains experimental test results electric motor based actuation direct yaw moment controller compared deriving friction brake based actuation algorithm major contribution paper novel results show continuous direct yaw moment control allows significant demand changes vehicle response cornering conditions enhance active vehicle safety extreme driving maneuvers authors published elsevier ltd
studies suggested possible association migraine increased risk ischemic stroke young adults particularly smokers women use oral contraceptive drugs aimed analyze association migraine ischemic stroke young population hospital based cohort included consecutive patients diagnosis ischemic stroke years age gender matched volunteers history stroke participants interviewed using questionnaire migraine localization ischemic lesion classified anterior posterior circulation according neuroimaging findings cause ischemic lesion risk factors recorded undetermined etiology frequent common determined cause cardioembolism young stroke patients frequency migraine among patients stroke whereas healthy subjects migraine migraine aura significantly common among patients stroke compared healthy subjects whereas frequency migraine without aura similar groups using logistic regression migraine aura shown independent risk factor ischemic stroke young population separate analysis gender demonstrated risk factor women men migraine aura found common ischemic stroke young patients independent risk factor women
present overview current sexual behavior adolescents israel including related social moral issues compare western countries important factor existence liberal versus conservative views regarding use contraception termination pregnancy young subjects describe current situation cases medical providers provide adequate contraceptive advice adolescent girls resulting ultimately high rate unintended pregnancy opinion essential make effective contraception accessible vulnerable group
nuclear quadruple resonance nqr studied explosive detection years prototype nqr based detection systems reported designed laboratory perspective bulky sizes high power consumption achieve portable nqr based detection system field applications low power compact system utilizing state art semiconductor technologies presented paper several novel circuits key modules proposed including class type power amplifier power multiplexing matching network customized integrated analog signal processing chain microcontroller based logic control unit advanced digital signal processor platform employed data collecting processing customized fabricated cmos process test results prototype system show effectiveness proposed solution low power consumption receiving state power efficiency proposed transmitting section higher
nuclear receptor car nri regulates hepatic drug energy metabolism well cell fate activation critical factor drug induced toxicity development diseases including diabetes tumors car inactivates constitutive activity phosphorylation threonine utilizing receptor protein kinase rack regulatory subunit protein phosphatase ppa dephosphorylates threonine activate car demonstrate car undergoes homodimer monomer conversion regulate dephosphorylation coexpression two differently tagged car proteins huh cells mouse primary hepatocytes mouse livers coimmunoprecipitation two dimensional gel electrophoresis revealed car form homodimer configuration ppa rack binding site buried within dimer interface epidermal growth factor egf found stimulate car homodimerization thus constraining car inactive form agonistic ligand citco binds directly car homodimer dissociates phosphorylated car monomers exposing ppa rack binding site dephosphorylation phenobarbital car ligand binds egf receptor reversing egf signal monomerize car indirect activation thus homodimer monomer conversion underlying molecular mechanism regulates car activation placing phosphorylated threonine common target direct indirect activation car
present study examined teachers domain specific self efficacy tse relation individual students variety social emotional behaviors class using sample third sixth grade students teachers multilevel modeling conducted examine students externalizing internalizing prosocial behaviors predictors tse toward individual students potential moderating roles teaching experience teachers perceived amount classroom misbehavior results showed variance tse occurred within teachers students externalizing behavior negatively associated tse instructional strategies behavior management student engagement emotional support contrast teachers reported higher levels self efficacy toward students high levels prosocial behavior irrespective teaching domain students internalizing behavior predicted lower levels tse instructional strategies emotional support higher levels tse behavior management last teachers perceived levels classroom misbehavior exacerbated negative association externalizing student behavior tse behavior management findings illustrate importance viewing tse dyadic perspective
research purposes background government corporation separation new situation impact railway construction management discussed thus suggestions pointed change management style national railway administration china railway corporation research conclusions separation work government corporation almost done china railway corporation still authority managing specific railway construction projects ministry railway charge regulations standard execute quality safety market management based function national railway administration multi objective implementation ability shall raised strengthen management quality safety supervision hand china railway corporation lose identity government advantage coordination company result harder carry forward progress railway construction thus changing period suggestions carry national railway administration enhance concept law responsibility project manager change management style give attention market contract order realize project governance project management research result applied construction management field reference construction management reformation national railway administration china railway corporation march original ministry railways abolished according state council organization reform function transformation plan national railway administration china railway corporation created national railway administration already established thus separation work government corporation work done officially based background government corporation separation focus transformation problem railway construction management new situation
popularization mobile personalized services motivates adoption learning strategies supported principles ubiquitous computing however new field perceived lack ubiquitous learning environments based reference architectures open source software backdrop article aims present youubi one learning environment developed component oriented reference architecture applied context formal informal learning validation youubi used installed undergraduate students teachers smartphones method applied research includes design process quantitative qualitative analysis techniques goal identifying scenarios ubiquitous learning realize impressions students teachers playful motivational aspects contribution learning elsevier ltd rights reserved
musculoskeletal ultrasound utilises high frequency linear transducers produce high resolution images soft tissue structures increasingly useful tool assessment acute chronic musculoskeletal injuries relatively cheap portable used facilitate targeted injections review paper aimto provide summary normal abnormal appearances skeletal tissue setting acute chronic lower limb sporting injuries
many people intellectual disabilities rely social care provision though little research looked access provision distributed nationally evidence children services suggests large discrepancies local authorities las terms resources expended interventions children families explained variations linked geographical location namely level socioeconomic deprivation las constituting child welfare inequalities study explored relationships resources allocated community services people intellectual disabilities england geographical factors including deprivation rurality political leadership las individuals reside data sourced publicly available reports spending english councils adult social services responsibilities cassrs cassr index multiple deprivation imd scores rurality period found deprived las supported people intellectual disabilities per population find effects rurality political party however case deprived las allocated funds expenditure group findings point inequities distribution social care resources people intellectual disabilities england although deprived las support people intellectual disabilities spend proportionally larger sums money group discuss possible explanations findings highlight need research particularly investigations allocation resources within las detailed explorations structural factors socioeconomic status service users effects service access local level
present eigenspectrum partitioning scheme without inversion recently described real space electronic transport code transec primary advantage transec highly parallel algorithm enables studying conductance large systems present scheme adds new source parallelization significantly enhancing transec parallel scalability especially systems many electrons principle partitioning could enable super linear parallel speedup demonstrate calculations within transec practical cases report better five fold improvement cpu time similar improvements wall time compared previously published large calculations importantly suggested scheme relatively simple implement useful general large hermitian weakly non hermitian eigenvalue problems whenever relatively accurate inversion via direct iterative linear solvers impractical elsevier rights reserved
anomalously slight glacier mass gain recently reported karakoram region however date investigations region wide glacier mass balance karakoram prior reported leaving knowledge gap assessing glacier responses climate change calculated elevation mass change using dems generated images acquired arc second srtm dem find slight mass loss less negative global average rate within karakoram glacier change patterns spatially temporally heterogeneous particular nearly stable state central karakoram period implies karakoram anomaly dates back combined previous studies conclude karakoram glaciers whole nearly balanced state
study investigated transactional pathways organizational stressors underpinning situational properties appraisals coping perceived coping effectiveness performance satisfaction athletes ten high level field hockey players interviewed data relating stressors situational properties appraisals coping analysed using directed content analysis mean perceived coping effectiveness scores calculated subjective performance satisfaction data categorized satisfied neutral dissatisfied variety organizational stressors reported underpinned five situational properties challenge threat harm loss appraisals experienced problem solving commonly reported family coping high perceived coping effectiveness always associated performance satisfaction performance satisfaction however linked appraisal experienced battery stress management techniques ways coping useful optimizing appraisals alleviating negative outcomes stress
suggest constructive definitions determination untangled finite graphs three periodic nets using barycentric embeddings two three dimensions possibility deliberately constructing tangled graphs nets canvassed conclude tangled patterns offer novel class nano meso structured materials useful features including high internal surface area volume chirality crown copyright published elsevier masson sas rights reserved
background relieving pain one fundamental responsibilities medical practitioners frequently primary goal patients seeking care many published reviews outlined problem showing patients receive ineffective inadequate delayed pain relief pain accompanies surgical procedures remains prevalent aspect perioperative experience generates greatest concern patients undergo surgery also growing concern acute painful experiences also lead long term painful consequences even tissue healing appears complete objective study assess intramuscular parecoxib regard efficacy pain relief duration action need supplements safety adverse effects materials methods study comprised postoperative patients sexes age group years scheduled various elective surgical procedures satisfied inclusion exclusion criteria patients visited preoperatively written informed consent taken premedicated diazepam body weight night parecoxib sodium given recovery room patient complained pain injection time noted time onset action parecoxib duration analgesia quality analgesia recorded vas heart rate blood pressure recorded intervals supplementary doses parecoxib necessary administered time noted adverse effects noted observations recorded tabulated subjected statistical analysis results study group male female mean duration analgesia vas hours quality analgesia excellent good vas patients significant change blood pressure heart rate hours intramuscular administration patients nausea vomiting headache pruritus conclusion intramuscular parecoxib useful pain relief postoperative analgesia half number patients study enjoying excellent analgesia vas hours patients vas hours intramuscular administration patients study needed supplementation rescue doses parecoxib sodium intramuscularly hours
partial progesterone estrogen receptor antagonist functioning actively silence progesterone receptor gene associated transcription reason used contraceptive abortive agent present study cellular gene specific effects investigated rat model early pregnancy including key phases window receptivity early implantation stages hormonally regulated progesterone estrogens focus elucidate mechanism action single dose used postcoital contraceptive successfully prevent implantation viable blastocyst immunofluorescent techniques used examine change protein levels treated endometria days pregnancy changes pgr gene expression level consequence administration evaluated using quantitative real time reverse transcription polymerase chain reaction progesterone receptor gene protein expression ubiquitously decreased throughout pregnancy direct consequence administration overall effects postcoital administration early pregnancy indicate highly effective inhibition progesterone estrogen effects endometrium mediated receptors specifically expression localization progesterone receptor mirrors described ovariectomized animal models suggesting hormonally stimulated endometrium clearly present study precise priming endomenium progesterone preparation blastocyst implantation severely impaired thus predisposing uterus pregnancy failure society biology reproduction institute animal reproduction food research polish academy sciences olsztyn published elsevier urban partner rights reserved
last years seen introduction advanced manycore processors well known devices like gpgpu intel mic less popular still interesting like epiphany also growing popularity cheap credit card sized devices offering advanced features high computational power one kind devices parallella board focuses parallel computing features epiphany coprocessor paper propose architecture distributed computational systems based parallella multiple instruction multiple data mimd coprocessor epiphany manycore processor consists sixteen cores connected mesh network chip presented architecture enables usage multiple parallella boards single system possibility also use computing units target usage system multi agent systems mas present selected scenarios could easily implemented would benefit properties provided multiple mimd devices
background heart rate variability reduced idiopathic indicating cardiac autonomic dysfunction likely resulting peripheral autonomic synucleinopathy little known heart rate variability leucine rich repeat kinase associated objectives study investigated heart rate variability lrrk associated methods resting electrocardiograms obtained individuals lrrk associated nonmanifesting carriers related noncarriers idiopathic patients controls linear regression modelling compared time frequency domain values adjusting age sex heart rate disease duration results low frequency power ratio low high frequency power reduced idiopathic versus controls respectively contrast individuals lrrk associated statistically different controls parameter measured furthermore parameters trended toward higher lrrk associated compared idiopathic conclusions heart rate variability may remain intact lrrk associated adding growing literature supporting clinical pathologic differences lrrk associated idiopathic international parkinson movement disorder society
popularity wet wipes application continues grow important part skin care millions people around world wet wipes may consist lots substances cause irritation skin allergy subsequently composition necessary identified aim study perform screening organic compounds wet wipes solid phase microextraction spme coupled gas chromatography mass spectrometry screening carried analysis six samples wet wipes alcohols esters ketones aldehydes acids aromatic compounds terpenes identified samples among identified alcohols methanol phenoxyethanol cause allergy identified propylene glycol referred group preservatives found samples derivatives benzene ethyl benzene methylethyl benzene butyl ethyl benzene also observed almost samples diethyl phthalate prohibited use hygiene products observed one wet wipe sample applied parameters solid phase microextraction gas chromatography mass spectrometry used future development quantitative methodology particular compounds phthalates alkoxyalcohols aromatic hydrocarbons preservatives
increasing global demand energy resources shale gas paid considerable attention recent years nanopore geometry basis microscopic rock physics petrophysical numerical experiments shale present nano digital cores acquired via thin section reconstruction nanometer scale ray computed tomography nano focused ion beam scanning electron microscopy fib sem fib sem detects nanoscale pores plane resolution voxel usually provides higher resolution nano main workload associated fib sem need recut sample many times scan every section overlaid create threedimensional pore model cutting distance ascertained controlled precisely fundamental limits focused ion beams many interpolation methods used fit anisotropy resolution however methods also alter geometry pores nanopores close limiting resolution particularly susceptible stretching linear interpolation likely lengthen pores low resolution direction subsequent calculation sensitive physical attributes affected geometric alterations foundational work compressive sensing method present reconstruction workflow maintaining pore shape using prior knowledge reliable information images reassembled equal distance nanoscale structures resolution unity three dimensions
review looking anti cytokine therapy rheumatoid arthritis psoriatic arthritis psa ankylosing spondylitis review explores similarities differences clinical features well treatments cytokines involved development propagation disease particular attention paid tnf alpha inhibitors jak kinase inhibitors anti new developments anti elsevier ltd rights reserved
novel information communication technologies create possibilities change future health care support ambient assisted living aal seen promising alternative current care models number researchers developed aal systems promising results main goal aal solutions apply ambient intelligence technologies enable people specific needs continue live preferred environments paper presenting general architecture system assisted living supports use cases system
paper proposes statistical framework develop user adapted spoken dialog systems proposed framework integrates two main models first model used predict user intention dialog second model uses prediction history dialog current moment predict next system response prediction performed ensemble based classifier trained tasks considered better selection next system attained weighting outputs specialized classifiers codification information definition data structures store data supplied user throughout dialog makes estimation models training data practical domains manageable describe proposal application detailed evaluation practical spoken dialog system
report fabrication characterization phresponsive hydrogel improved mechanical dielectric properties cellulose nanocrystals ray diffraction sem observations used analyze sample morphology resulting detector exhibits pronounced change swelling index response variation used singly combination nanomaterials optimize smart material designs applications developed material anticipated chemical environmental biological systems
paper presents design implementation cellular automata model predicts damage forging tools due fatigue transition rules model developed basis known information regarding crack initiation propagation coefficients model determined inverse analysis thermal fatigue tests performed gleeble simulator special device rotating disc model coupled conventional abrasive wear model layers cell space contact workpiece removed successively following abrasive wear tool model connected finite element programme simulates stresses tools forging since multiscale approach appeared extremely demanding far computing times considered efficient implementation model heterogeneous hardware architectures prepared results simulations compared industrial data good predictive capabilities model confirmed published elsevier behalf politechnika wroclawska
micrornas mirnas small non coding rnas control gene expression posttranscriptionally part giant non codifying genoma cumulating data suggest mirnas promising potential biomarkers many diseases including cancer prostate cancer pca detection currently based serum prostate specific antigen biomarker digital rectal examination however methods limited low predictive value adverse consequences associated overdiagnosis overtreatment new biomarkers could used pca detection prognosis still needed recent studies demonstrated aberrant expressions micrornas associated underlying mechanisms pca review attempts extensively summarize current knowledge mirna expression patterns well targets involvement pca pathogenesis focused review value circulating urine mirnas biomarkers pca patients highlighting existing discrepancies different studies probably associated important methodological issues related quantitation normalization majority studies performed serum plasma urine obtained prostate massage appears new way explore usefulness mirnas large screening studies select mirna profile completed bioinformatics tools appear new approach select mirnas relevant pca development promising preliminary results published concerning mir mir mir larger prospective studies using standardized methodology necessary define value mirnas detection prognosis pca
paper describes strategy identify authorship online handwritten documents regard research framework retrieval problem adapt called codebook based vector local aggregate descriptor vlad promising object retrieval application image processing codebook comprises set code vectors associated voronoi cells computed clustering algorithm set feature vectors along online trace however show vlad formulation times effectively discriminate writers respective feature vectors linearly separable voronoi cell code vectors overcome problem propose novel descriptor improves upon vlad formulation secondly explore normalization feature vectors prior generation vlad method different min max score takes care ensuring codevectors influenced presence outliers data performance proposed descriptor new feature normalization evaluated two publicly available online handwriting databases iam ibm results show marked improvement vlad elsevier ltd rights reserved
adolescents young adults continue develop rapidly especially high cognitive functions working memory sleep regular exercise shown affect brain cognitive functions investigated interplay two factors working memory one hundred participants completed sleep exercise log wore acti watch five days performed working memory task sixth day regular exercisers found significantly faster response time working memory task non regular exercisers effect moderated actigraphy measured total sleep time words regular exercisers faster reaction time non regular exercisers sufficient sleep hours findings showed healthy sleep regular exercise habits promoted among adolescents young adults optimize cognitive development
dye sensitized solar cells dsscs type photovoltaic device received widespread attention recent years comparison silicon photovoltaic cells dsscs exhibit specific advantages including easy fabrication procedures low manufacturing cost compatibility flexible substrates spite advantages mentioned industrial point view efficiency long term stability dsscs system subject concern past years development technology order solve problems numerous research efforts devoted engineering manufacturing devices could meet standards photovoltaic cells market various applications low efficiency stability remained major challenges development dsscs past year review focuses obstacles restrictions fabrication commercialization dsscs losses potential limiting efficiency degradation processes discussed external effective factors stability dssc therrhal light soaking stresses environmental conditions issues related sealing investigated detail also commercial photovoltaic technology dsscs term efficiency stability lifetime compared different types photovoltaic solar cells results indicate despite many attractive features technology transition laboratory industry outdoor applications hampered number issues
objective spending money others prosocial spending improve cardiovascular health community dwelling older adults diagnosed high blood pressure method study older adults diagnosed high blood pressure participating midlife study midus examined study older adults diagnosed high blood pressure assigned spend money others spend money results study money people spent others lower blood pressure years later study participants assigned spend money others consecutive weeks subsequently exhibited lower systolic diastolic blood pressure compared participants assigned spend money magnitude effects comparable effects interventions antihypertensive medication exercise conclusions together findings suggest spending money others shapes cardiovascular health thereby providing pathway prosocial behavior improves physical health among risk older adults
objective previous studies indicated suicide rates significant seasonal variations seasonal discordance temperature solar radiation due monsoon season south korea investigated seasonality suicide assessed association climate variables south korea method suicide rates obtained national statistical office south korea climatic data obtained korea meteorological administration period conducted analyses using generalized additive model gam first explored seasonality suicide climate variables mean temperature daily temperature range solar radiation relative humidity next identified confounding climate variables associated suicide rate estimate adjusted effect solar radiation suicide rate investigated confounding variables using multivariable gam results suicide rate showed seasonality pattern similar solar radiation found suicide rate increased times solar radiation increased adjusting confounding climate factors conclusion solar radiation significant linear relationship suicide adjusting region climate variables time trends
recent environmental economic considerations made focus attention new treatment processes residual tail gas claus plants based oxidative decomposition sulphur hydrogen work thermal oxidative decomposition homogeneous phase studied developing comprehensive chemical kinetic model oxidation low oxygen atmosphere varying ratio residence time process temperatures omicron kinetic model developed combining existing models oxidation tuning parameters kinetic constants validated relation experimental data results show good agreement experimental values higher temperatures omicron omicron conversion well predicted model whereas yield selectivity consistently higher experimental values sensitivity analysis complex kinetic system highlighted importance reaction lower temperatures elsevier ltd rights reserved
context increasing popularity systematic literature review slr process also increasing need tool support objective goal work consult software engineering researchers conduct slrs identify prioritize necessary slr tool features method gather information required address goal invited slr authors participate interactive workshop structured around nominal group technique results workshop outcomes indicated search selection collaboration two highest priority tool features results also showed high priority features well supported current tools conclusion results support extend results prior work slr tool authors use findings guide future development efforts elsevier rights reserved
difficulty retrieving abutment screw major disadvantage cement retained implant restorations conventional methods locating screw access hole based largely radiography manual labor limits accuracy clinical feasibility clinical report describes non radiological method fabricating accurate drilling guide location screw channel using intraoral optical scanning superimposition computer aided design computer aided manufacturing cad cam technologies present technique improves guide fabrication process accuracy screw channel drilling also wide indications implant restorations
dimensional field testing activity described paper allowed measuring vertical transverse dynamic displacement related main span dimension equal meters central section long span suspension bridge april bridge lisbon portugal using optical system composed high focal length lens digital image sensor active infrared led targets maximum values obtained vertical transverse displacements without rail traffic passenger train circulation bridge lower rail deck increased vertical displacement applied measuring system subjected situ calibration procedure traceable showing maximum deviations close expanded measurement uncertainty confidence interval around favorable observation scenario winter season low vertical thermal gradient atmosphere field studies optical phenomena atmospheric refraction beam wandering effect turbulence also performed aiming validation developed refraction correction models quantification targets image coordinates dispersions pixel winter season pixel summer season
lasers photodynamic therapy considered convergence treatment onychomycosis fungal infection nail bed nail plate laser therapies shown satisfactory results without significant complications onychomycosis however mechanism clearing remains unknown work investigated changes chemical structure nail keratin induced yag laser using raman spectroscopy toe nails onychomycosis treated yag laser laser treatment disulfide band nail keratin rarely observed reduced intensity amide band also showed changes induced laser helical structures dominated beta sheet nontreated nail opposite phenomenon observed laser treatment
development ambient assisted living systems would facilitated development environment allowed simulate computer physical environment inhabitants well ambient assisted living system requires one hand infrastructure simulating physical environment hand infrastructure emulating ambient assisted living devices interconnected data streams allow emulated devices behave connected real world since get similar sensor input paper introduces advances simulation framework ambient intelligence becomes capable producing data streams
logitech made following statement since displacements mouse would give useful information hacker mouse reports encrypted paper prove exact opposite true indeed possible leak sensitive information passwords displacements bluetooth mouse results easily extended wireless mice using different radio links begin presenting multiple ways sniff unencrypted bluetooth packets containing raw mouse movement data show data may reveal text based passwords entered clicking software keyboards propose two attacks prediction attack replay attack reconstruct screen cursor trajectories sniffed mouse movement data two inference strategies used discover passwords cursor trajectories conducted holistic study popular operating systems analyzed mouse acceleration algorithms packet losses may affect reconstruction results real world experiments demonstrate severity privacy leakage unencrypted bluetooth mice also discuss countermeasures prevent privacy leakage wireless mice best knowledge work first demonstrate privacy leakage raw mouse data
background hand dermatitis serious health problem healthcare workers range skin care strategies policy directives developed recent years minimise risk effectiveness cost effectiveness remain unclear evidence suggests psychological theory facilitate behaviour change respect improved hand care practices therefore test hypothesis behavioural change intervention improve hand care based theory planned behaviour implementation intentions coupled provision hand moisturisers produce clinically useful reduction occurrence hand dermatitis compared standard care among nurses working national health service nhs particularly risk secondary aims assess impacts participants beliefs behaviour regarding hand care addition assess cost effectiveness intervention comparison normal care methods design conduct cluster randomised controlled trial nhs hospital trusts health boards universities focussing student nurses previous history atopic disease hand eczema nurses intensive care units nurses intervention light sites managed according would currently regarded best practice provision advice leaflet optimal hand care prevent hand dermatitis encouragement contact occupational health department early hand dermatitis occurs nurses intervention plus sites additionally receive behavioural change programme bcp going active reinforcement messages enhanced provision moisturising cream impact interventions compared using information collected questionnaires standardised photographs hands wrists collected baseline months follow addition assemble relevant economic data analysis costs benefits collect information various sources evaluate processes statistical analysis multi level regression modelling allow clustering site compare prevalence outcome measures follow adjustment values baseline principal outcome measure prevalence visible hand dermatitis assessed study dermatologists addition several secondary outcome measures assessed discussion trial assess clinical cost effectiveness intervention prevent hand dermatitis nurses united kigdom
background psoriasis vulgaris characterized disfiguring stigmatizing skin lesions links among lesions distribution severity stigmatization remain unclear objective sought investigate involvement visible sensitive areas linked stigmatization methods patients psoriasis vulgaris assessed disease severity skin lesions distribution itch stigmatization using feelings stigmatization questionnaire quality life assessed dermatology life quality index world health organization quality life bref results localization psoriatic lesions back hands related higher stigmatization levels total score feelings stigmatization questionnaire involvement nails palms face genital area overall disease severity patients reported level stigmatization regardless localization lesions type psoriasis higher levels stigmatization characterized patients claimed able hide lesions clothing women unemployed stigmatization strongest predictor quality life impairment limitations hospitalized patients included conclusions psoriatic lesions back hands debilitating warrant effective treatment special attention paid female patients sensitive stigmatization
research designed investigate relationship sympathetic parasympathetic autonomic nervous system ans responses perception social targets varying social status participants varying subjective financial status presented faces assigned either low average high financial status electrocardiographic impedance cardiography signals recorded measures sympathetic pre ejection period pep parasympathetic high frequency heart rate variability hrv cardiac control derived measures associated presentation face condition examined relation subjective status perceivers participants high subjective financial status showed reduced sympathetic activity viewing low medium status targets compared high status targets lower parasympathetic response viewing high medium status targets relative low status targets published elsevier
paper deals dynamic analysis straightening machine loading straightening process crooked bar passing machine rollers holders subjected dynamic loadings roller moment amplitudes depend among others straightening speed size bar curvature bar diameter friction bar rollers loading time varying knowledge frequencies moment important used verification numerical simulation straightening machine design machine operation close resonance state cause excessive vibration subsequently cause noise adversely affect life machine also straightening accuracy paper aimed analyze frequency spectra moments obtained computational simulation find possible causes vibration although straightening process complex possible identify three main causes vibration presented results paper
hypervisors enable cloud computing model provide scalable infrastructures demand access computing resources support multiple operating systems run one physical server concurrently mechanism enhances utilization physical server thus reduces server count data center hypervisors also drive benefits reduced infrastructure setup maintenance costs along power savings interesting know different hypervisors performance consolidated application workloads three hypervisors esxi xenserver kvm carefully chosen represent three categories full virtualized para virtualized hybrid virtualized respectively experiment created private cloud using cloudstack hypervisors deployed hosts private cloud respective clusters hypervisor deployed three virtual machines three applications web server application server database servers installed three virtual machines experiments designed using design experiments doe methodology concurrently running virtual machines hypervisor stressed consolidated real time workloads web load application load oltp important system information gathered using sigar framework paper proposes new scoring formula hypervisors performance private cloud consolidated application workloads accuracy results complemented sound statistical analysis using doe elsevier rights reserved
objective initial treatment juvenile idiopathic arthritis jia largely based extent joint involvement disease severity ilar category licensing biologic therapies jia expanded treatment options aims study describe treatment prescribing patterns jia first years following first presentation paediatric rheumatology determine whether patterns treatment changed biologics become widely available methods children least years follow within childhood arthritis prospective study caps included analysis children placed one five groups according initial presentation paediatric rheumatology oligoarthritis ojia polyarthritis pjia systemic sjia enthesitis related arthritis era psoriatic arthritis psa treatment patterns years described results children received synthetic disease mpdifying anti rheumatic drugs sdmard received biologics years use sdmards biologics higher severe disease presentations sjia pjia however presented ojia also treated dmards biologics respectively number children receiving sdmard higher however difference biologic prescribing conclusions high proportion children presenting jia received sdmards plus minus biologics years follow common patients severe jia also prescribed patients oligoarticular disease despite lack evidence effectiveness category authors published elsevier journals inc
several methods estimating prevalence dementia presented article brookmeyer chicago health aging project chap estimates prevalence derived statistically forward calculating incidence survival figures choice incidence rates build estimates may critical brookmeyer used incidence rates several published studies whereas chap investigators applied incidence rates observed cohort aging demographics memory study adams east boston senior health project ebshp sample surveys designed ascertain prevalence alzheimer disease dementia adams obtained direct estimates relying probability sampling nationwide ebshp relied projection localized prevalence estimates national population sampling techniques adams ebshp rather similar whereas disease definitions contrast ebsph chap similar disease definitions internally use different calculation techniques yet arrive similar prevalence estimates considerably greater obtained either brookmeyer adams choice disease definition may play larger role explaining differences observed prevalence studies alzheimer association rights reserved
study role environment evolution central satellite galaxies sloan digital sky survey begin studying size mass relation replicating previous studies showed difference sizes centrals satellites fixed stellar mass turning attention size core velocity dispersion sigma mass sigma relations comparing median size mass galaxies fixed velocity dispersion find central galaxies consistently larger massive satellite counterparts quiescent population star forming population find difference size small difference mass analyse difference may present investigate radial mass profiles stellar metallicity galaxies find cores galaxies difference mass surface density centrals satellites large difference larger radii also find almost difference stellar metallicity centrals satellites separated star forming quiescent groups assumption sigma invariant environmental processes results imply central galaxies likely increased mass size processes minor mergers particularly high sigma satellites slightly reduced mass size tidal stripping harassment particularly low sigma pre dominantly affect outer regions galaxies
high use conventional resources electricity production fact resources diminish every passing day increased studies carried renewable energy sources however use renewable energy sources efficient way possible one topics come foreground fact led technology used illumination systems provides energy saving study electric energy obtained photovoltaic panels accumulated battery groups sensitive illumination intensity motion taken ambient light sensor proposed algorithm controls light level led direct current characters comparison normal led illumination systems energy saving attained
objective review years national collegiate athletic association injury surveillance data women lacrosse identify potential areas injury prevention initiatives background women lacrosse fast paced primarily noncontact sport participation collegiate women lacrosse almost doubled seasons lacrosse equipment consists sticks made wood synthetic material hard rubber ball recently mouth guards required protective equipment main results collegiate women lacrosse game injury rates increased year study period severe game injuries lower extremity sprains strains knee internal derangements frequently result noncontact incidents common injury scenarios injury mechanism player activity contact ball handling contact stick ball handling contact stick ball accounted injuries sustained shooting activities respectively approximately game practice injuries involved head neck contact stick accounted majority neck injuries games contact ball accounted injuries participants times risk sustaining concussion game practice versus injuries per athletic exposures rate ratio confidence interval recommendations reduce lower extremity injuries comprise greatest injury burden women lacrosse future researchers evaluate proprioceptive plyometric balance training interventions designed specifically female players research areas great interest involve determining whether protective eyewear mandated reduces injuries eye orbit nasal area identifying unintended consequences mandate increased risk injuries areas face aggressive play
field power drive systems electrical machines mostly modeled using set explicit ordinary differential equations state space representation shown using equation types simulation algebraic constraints arising aggregating several machines complex system directly considered effects different model variants numerical ode dae solvers investigated focus work order perform efficient simulations larger systems possessing electrical machines
mobile devices namely phones tablets long gone smart growing use cause effect technological advancement among others increasing ability store exchange sensitive information caused interest exploiting vulnerabilities opposite need protect users data secure protocols access identification mobile platforms face iris recognition especially attractive since sufficiently reliable require webcam normally equipping involved devices contrary alternative use fingerprints requires dedicated sensor moreover icinds biometrics lend uses beyond security ambient intelligence services bound recognition user well social applications automatic photo tagging social networks especially exploit face recognition paper describes firme face iris recognition mobile engagement biometric application based multimodal recognition face iris designed embedded mobile devices design implementation firme rely modular architecture whose workflow includes separate replaceable packages starting one handles image acquisition point different branches perform detection segmentation feature extraction matching face iris separately face antispoofing step also performed segmentation finally results two branches fused order address also security critical applications firme perform continuous reidentification best sample selection address possible limited resources mobile devices algorithms optimized low demanding computation light elsevier rights reserved
differential response system reform allows child protective services cps agencies divert low moderate risk families investigative track alternate track require maltreatment disposition identification alleged perpetrator knowledge alters flow cases cps systems restricted methodological limitations prior research study uses cross sectional longitudinal data national child abuse neglect data system ncands child file examine extent implementation affects number demographic composition cases investigated neglect results multivariate multilevel cross sectional analysis data indicated investigations times likely substantiated counties non counties children previous substantiated report also likely current report substantiated difference significantly greater counties non counties child race ethnicity predict substantiation decisions results mixed effect longitudinal analysis cases counties suggest rate investigations fell sharply nationwide within three years implementation however substantiation rates change result implementation instead analysis indicated differences non counties emerged launch findings highlight benefit using big data longitudinal analysis assess large scale policy changes elsevier ltd rights reserved
one today motivating medical image processing problem registration medical images acquired different modalities give rise practical problem image registration many years mutual information utilized similarity criterion registration therefore believed state art field nonetheless understood non convex possess many local maxima overcome problem introduce novel evolutionary rigid body docking erbd algorithm medical image registration ligand taken non aligned target image registered protein reference image alignment target image changed per optimal configuration paper introduces firsthand objective fitness function finding optimal configurations genetic algorithm used optimize fitness function proposed method useful recovery rotation translation parameters different image data formats like magnetic resonance image mri computed tomography positron emission tomography pet images retrospective image registration evaluation rire project used demonstrate effectiveness proposed method experimental results presented reveal fact approach seems efficient
nurses swedish child school healthcare need balance assignment promoting children health development based national health monitoring programme responsibility consider child needs balancing act encounter children directed pliable strategies fulfil professional obligations aim study analyse extent nurses use different strategies encountering children recurrent health visits throughout childhood quantitative descriptive content analysis used code video recordings displaying nurses encounters children years age constructed observation protocol used identify codes results show nurses use pliable strategies directed strategies encounters children action use within pliable strategy encouraging directed strategy action use instructing primarily use opposing actions understood trying synthesize twofold assignment however seem act pliably able fulfil public function dictated national health monitoring programme rather meet child needs
data suggest myoblasts various sources including bone marrow skeletal muscle adipose tissue restore muscle function patients urinary incontinence animal data indicated progenitor cells exert mostly paracrine effect native tissues rather cell regeneration limited knowledge available vivo effect human stem cells muscle progenitors injured muscles examined vivo integration smooth muscle progenitor cells psmcs derived human pluripotent stem cells hpscs psmcs derived human embryonic stem cell line escs two induced pluripotent stem cell ipsc lines psmcs injected periurethrally urethral injury rat models cells per rat intramuscularly severe combined immunodeficiency mice histologic quantitative image analysis revealed urethras psmc treated rats contained abundant elastic fibers thicker muscle layers compared control rats western blot confirmed increased elastin collagen iii content urethra bladder psmc treated rats compared controls ipsc psmc treatment also showed similar trends elastin collagen iii human elastin gene expression detectable rodent tissues suggesting extracellular matrix synthesis resulted native rodent tissues rather implanted human cells immunofluorescence staining vivo bioluminescence imaging confirmed long term engraftment psmcs host urethra persistence smooth muscle phenotype taken together data suggest hpsc derived psmcs facilitate restoration urethral sphincter function direct smooth muscle cell regeneration inducing native tissue elastin collagen iii remodeling stem cells translational
background pain may reported one half three fourths children cancer terminal conditions anxiety one third pharmacologic methods always give satisfactory symptom relief complementary therapies reiki may help children manage symptoms objective pre post mixed methods single group pilot study examined feasibility acceptability outcomes pain anxiety relaxation using reiki therapy children receiving palliative care methods convenience sample children ages parents recruited palliative care service two minute reiki sessions completed children home paired tests wilcoxon signed rank tests calculated compare change pre post outcome variables significance set cohen effect sizes calculated results final sample included verbal nonverbal children mothers nurse mean scores outcome variables decreased pre posttreatment sessions significant decreases pain treatment nonverbal children respiratory rate treatment verbal children cohen effect sizes medium large outcome measures discussion decreased mean scores outcome measures indicate reiki therapy decrease pain anxiety heart respiratory rates small sample size deterred statistical significance preliminary work suggests complementary methods treatment reiki may beneficial support traditional methods manage pain anxiety children receiving palliative care
well known practice accelerate construction projects overlap design phase activities typical construction project number overlapping strategies exist design phase result timesaving however cost strategies varies significantly depending total rework complexity generate favorable overlapping strategy one generates required timesaving minimum cost find strategy question activities overlapped extent reduce project duration minimum cost answered research aimed answering question generating overlapping optimization algorithm algorithm works based principles genetic algorithms gas algorithm explained paper unique compared previous algorithms frameworks available literature optimize multi path networks handle types activity dependencies finish start start start finish finish also takes critical non critical activities account follows critical path critical path changes new critical paths emerge computer tool also developed run examine validate overlapping optimization algorithm paper introduces algorithm computer tool detail explains results validation optimizing real world project schedule elsevier rights reserved
identification model multivariable controlled autoregressive moving average carma like system contains parameter matrix parameter vector performed standard least squares method order solve identification problem transform carma like system regression identification models number outputs parameter vector use recursive maximum likelihood identification algorithm estimate parameter vectors submodels proposed algorithm simple effective high estimation accuracy
condit dam one largest hydroelectric dams ever removed usa breached single explosive event october hundreds thousands cubic metres sediment washed white salmon river onto spawning grounds threatened species columbia river tule fall chinook salmon oncorhynchus tshawytscha investigated year period dam breaching affected channel morphology river hydraulics sediment composition tule fall chinook salmon hereafter tule salmon spawning habitat lower white salmon river project area expected dam breaching dramatically affected channel morphology spawning habitat due large load sediment released northwestern lake forty two per cent project area previously covered water converted islands new shoreline large pool near mouth filled sediments delta formed mouth two dimensional hydrodynamic model revealed pool area decreased project area glides riffles increased respectively spatially explicit habitat model found mean probability spawning habitat increased dam breaching due increase glides riffles shifting channels bank instability continue negatively affect spawning habitat sediments continue wash downstream former northwestern lake new spawning habitat river kilometre formed immediately post breach persisted less tule salmon spawned upstream former dam site date run sizes appear healthy stable published article government work public domain usa
neurological injury often associated cardiac abnormalities including electrophysiological issues cardioversion acute atrial fibrillation duration without anticoagulation carries risk thromboembolism limited data managing acute atrial fibrillation specifically neuroscience intensive care unit nsicu setting sought determine safety using intravenous amiodarone restoring sinus rhythm patients presumed new onset atrial ventricular tachycardia neurological injury conducted retrospective review consecutive patients admitted nsicu june march primary neurological diagnosis new onset tachyarrhythmias received amiodarone baseline demographics presence known risk factors atrial fibrillation recorded primary end point new onset stroke patients included final analysis patients developed new stroke receiving amiodarone average follow period days majority patients pre identified risk factors atrial fibrillation lschemic stroke traumatic brain injury common admitting diagnoses conclude patients primary neurological injury use amiodarone rhythm control acute onset atrial fibrillation carries low risk cardioembolic stroke first weeks investigation including prospective studies larger samples longer follow periods warranted elsevier ltd rights reserved
ongoing exposure political violence prompt subject groups support oppose compromise situations intractable conflict mechanism underlying processes political scholarship neither offers conclusive arguments sufficiently addresses individual level forms exposure violence context political conflict particularly factors mediating political outcomes address looking impact exposure political violence psychological distress perceived threat ethos conflict support political compromise mediated model hypothesized whereby exposure political violence provokes support ethos conflict hinders support compromise perceived psychological distress perceived national threat examined representative samples two parties conflict israelis palestinians gaza east jerusalem west bank study main conclusion ethos conflict serves mediating variable relationship exposure violence attitudes toward peaceful settlement conflict
main objective paper evaluate feasibility performance building materials similar gas concrete using epoxidized canola oil eco fly ash natural clay natural zeolite study eco wastes produced afayin elbistan kahramanmaraay turkey thermal power station used producing building material used raw materials producing samples eco used binding density thermal conductivity compressive tensile strength decreased increase eco levels replacements moreover increasing process temperatures decreased density thermal conductivity compressive tensile strength abrasion loss water absorption increased increase eco ratios process temperatures
maintain upright posture prevent falling balance control involves complex interaction nervous muscular sensory systems sensory reweighting balance impaired compliant foam mats used training methods improve balance control however effect compliance foam mats sensory reweighting remains unclear study eleven healthy subjects maintained standing balance eyes open continuous support surface rotations disturbed proprioception ankles multisine disturbance torques applied trials three levels compliance combined three levels desired rotation amplitude two trials repeated eyes closed corrective ankle torques response rotations assessed frequency response functions frf lower frequency magnitudes lfm calculated averaging frf magnitudes lower frequency window representative sensory reweighting results showed increasing rotation amplitude leads decrease lfm addition interaction effect decrease lfm increasing rotation amplitude less compliant trials eyes closed larger lfm compared trials eyes open conclude balance control trained using foam mats two different effects kept mind increase compliance known effect causing larger rotations therefore greater weighting proprioceptive information however compliance influences sensitivity sensory reweighting changes rotation amplitude relatively less reweighting occurring compliant surfaces amplitude changes elsevier rights reserved
smart environments sme richly integrated multiple heterogeneous devices perform operations intelligent manner considering context actions behaviors users major objective enable environment provide ease comfort users reliance systems demands consistent behavior versatility devices user behavior intricacy communication complicate modeling verification sme reliable behavior many available modeling verification techniques formal methods appear promising due large variety implementation scenarios support conditional behavior processing concept sme applicable diverse areas calls focused research result number modeling verification techniques made available designers paper explores puts perspective modeling verification techniques based extended literature survey techniques mainly focus specific aspects overlapping scenarios user interaction devices interaction control context awareness etc interest researchers based specialized competencies techniques categorized basis various factors formalisms considered modeling verification later analyzed results show surveyed technique maintains holistic perspective technique used modeling verification specific sme aspects results help designers select appropriate modeling verification techniques given requirements stress effort sme modeling verification research
problem computing edge connected components eccs graph specific fundamental graph problem investigated recently paper study problem ecc decomposition computes eccs graph possible values ecc decomposition widely applied variety applications graph topology analysis community detection steiner component search graph visualization straightforward solution ecc decomposition apply existing ecc computation algorithm compute eccs values however solution applicable large graphs two challenging reasons first existing ecc computation algorithms highly memory intensive due complex data structures used algorithms second number possible values large resulting high computational cost value independently considered paper address challenges study efficient ecc decomposition via graph reduction introduce two elegant graph reduction operators aim reduce size graph loaded memory preserving connectivity information certain set edges computed specific also propose three novel efficient algorithms bottom top hybrid explore values different orders reduce redundant computations different values analyze memory costs proposed algorithms addition extend algorithm build efficient index steiner component search show index used perform steiner component search optimal node information graph allowed loaded memory experiments evaluate algorithms using seven real large datasets various graph properties one contains billion edges experimental results show proposed algorithms scalable efficient
aim study follow several sequence histological changes occur histogenesis rumen one humped camel camelus dromedarius histogenesis study carried fetuses camel day gestation birth days according relevant histo differentiation characteristics rumen fetuses divided four groups group crown rump length days group days group iii days group days days rumen consisted four layers epithelial layer propria submucosa tunica muscularis serosa epithelium glandular region pseudostratified non glandular region stratified muscularis mucosa observed incompletely days lamina propria submucosa glandular region rumen birth day primary lymphatic nodules appeared lamina propria glandular region rumen days gestation epithelium glandular region rumen formed simple columnar layer days groups tunica muscularis layer rumen increased ruminal development gradually non glandular region rumen formed stratified epithelium number cells increased ruminal development lymphatic nodules muscularis mucosa non glandular region observe groups study observations revealed non glandular region rumen fetuses camel less precocious rumen domestic ruminants pvj rights reserved
levodopa dopa dihydroxyphenylalanine effective drug symptomatic treatment parkinson disease chronic use initiates maladaptive process leading dopa induced dyskinesia lid risk factors early onset lid include younger age severe disease baseline higher daily dopa dose biomarkers predict risk motor complications yet available investigated whether csf levels catecholamines metabolites altered patients lid lid compared non dyskinetic patients receiving dopa receiving dopa well non controls patients clinically assessed using unified parkinson disease rating scale unified dyskinesia rating scale csf collected overnight fasting oral intake dopa anti parkinson medication csf catecholamines metabolites analyzed hplc electrochemical detection observed decreased levels dihydroxyphenylacetic acid dopac homovanillic acid patients receiving dopa higher dopamine levels lid compared controls iii higher dopa lower dopac ratio lid compared age dependent increase decrease dopac ratio controls results suggest increased release non cells deficient uptake lid monitoring dopac csf dopa treated patients may help identify patients risk developing lid
study three different types scaffolds including uniquely modified composite scaffold namely chitosan cts nano hydroxyapatite chitosan composite cts nhap amine group modified nano hydroxyapatite chitosan composite cts nhap scaffolds synthesized bone tissue engineering bte purposes results study found scaffold types biodegradable cts cts nhap scaffolds losing initial weight cts nhap scaffold showing weight loss six weeks lysozyme treatment addition three types scaffolds shown biocompatible amongst cts nhap scaffolds supported cell proliferation wst assay expressed least acceptable level cytotoxicity lactate dehydrogenase ldh test human bone mesenchymal stem cells hbm mscs finally osteoinductivity assessment cts nhap nearly tripled initial alkaline phosphatase alp activity whereas cts cts nhap scaffolds doubled results indicate synthesized scaffold types investigation certain potential used bone tissue engineering approaches cts nhap scaffold promising applicable one future plan intensify studies osteogenic differentiation scaffolds detailed molecular level include vivo studies pre clinical purposes elsevier ltd rights reserved
importance names demonstrated decision making related individuals well companies previous researchers focused traits fluency names present three studies focus role hard sound relation helping behavior pronunciation sound requires facial movement mimics smile particularly sound occurs end name research complements previous findings generated theory embodied cognition biting pencil chopstick evoked behavioral mood changes study finds participants likely help someone whose name ends sound study utilizes broader set contrasting sounds finds basic preference sound specific women study shows women significantly likely recall addressing parents mommy daddy soliciting help rather mom dad findings complement previous research concerning motherese highlight phonetic cue prosocial behavior appears offer insights marketing management current studies important understanding interpersonal interactions findings direct relevance marketing campaigns focus consumer engagement
background present study evaluated relationships serum biomarkers clinical magnetic resonance imaging mri findings golimumab treated patients ankylosing spondylitis methods raise study patients ankylosing spondylitis randomly received either placebo golimumab injections every weeks week placebo controlled patients continuing raise received golimumab week patients sera collected biomarkers serial spine mri scans sagittal plane scanner two blinded readers employed modified ankylosing spondylitis spine magnetic resonance imaging score activity asspimri ankylosing spondylitis spine magnetic resonance imaging score chronicity spearman correlations assessed serum biomarkers bath ankylosing spondylitis disease activity index basdai reactive protein crp based ankylosing spondylitis disease activity score asdas modified stokes ankylosing spondylitis spine score msasss asspimri scores serum biomarkers predicting postbaseline spinal fatty lesion development inflammation analyzed logistic regression results significant moderately strong correlations observed baseline inflammatory markers interleukin intracellular adhesion molecule complement component crp haptoglobin serum amyloid baseline asdas baseline leptin significantly correlated asdas improvement week baseline significantly predicted msasss week change beta model logistic regression baseline leptin tissue inhibitor metalloproteinase timp correlated new fatty lesions per spinal mri week week changes serum levels week week significantly correlated basdai improvement week baseline timp reductions week significantly correlated week asspimri improvement conclusions extensive serum biomarker multiparametric analyses golimumab treated patients ankylosing spondylitis demonstrated correlations disease activity mri changes weakly correlated radiographic progression
soft mudstone dominates rock mass southwest taiwan mudstone slakes significantly meets water due short diagenetic period poor cementation gulleys visible surface mudstone slopes rainfall low slaking durability resistance mudstone causes geographical badland also erosion problems highway slopes mudstone area effective countermeasure protecting mudstone slope must contribute reduction surface erosion facilitate drainage slope surface rainfall incorporate high strength structure fight swelling stress preserve vegetation contribute slope stabilization study new slope erosion countermeasure soil tyre vegetation method stv applied excavated mudstone slope southwest taiwan stv utilizes waste tyres beams geotextile waste tyres good preserving soil vegetation mudstone slopes mitigating slope erosion beams support weight vegetation soil filled tyres geotextile prevents loss fine grain soil guarantees drainage slope heavy rainfall experimental results mudstone slope slope angle degrees showed stv protected mudstone slope improved condition vegetation
objective study whether reported inconsistent associations fmr cgg repeat lengths intermediate high normal low normal range differentiate women diagnosed diminished ovarian reserve dor population controls whether associations vary race ethnic group design case control study setting academic private fertility clinics patient dor cases whites asian five fertility clinics clinically diagnosed regular menses fragile syndrome family history normal fertility controls whites african americans japanese chinese united states based swan study one menstrual period months preenrollment one pregnancy history infertility hormone therapy menopause years previously swan chinese japanese groups similar fmr cgg repeat lengths thus combined intervention none main outcome measure fmr cgg repeat lengths result median cgg repeats nearly identical case control group dor cases fewer cgg repeats shorter fmr allele controls among whites significant among asians white cases fewer cgg repeats shorter allele asian cases significant differences found high normal intermediate range cases controls race ethnic group within cases longer allele conclusion study refutes prior reports association dor high normal intermediate repeats confirms association dor low normal repeats whites american society reproductive medicine
paper proposes optimization based approach designing rainwater harvesting systems domestic use residential development optimization model accounts implementation rainwater harvesting devices pipes reservoirs optimal sitting collecting storing distribution harvested rainwater optimization model consists satisfying water domestic demands considers objective function minimization total annual cost associated fresh water capital costs catchment areas storages pumps cost associated pumping maintenance treatment case study residential development morelia mexico presented city morelia characterized complications satisfy water demands especially dry seasons application proposed optimization approach shows possible satisfy significant percentage domestic water demands using harvesting rainwater system decreasing associated cost time horizon several scenarios presented show potential solutions identified case study elsevier rights reserved
new taxonomy issues related cad model quality presented distinguishes explicit procedural models type model morphologic syntactic semantic errors characterized taxonomy validated successfully used classify quality testing tools aimed detecting repairing data errors may affect simplification interoperability reusability cad models study shows low semantic level errors hamper simplification reasonably covered explicit representations although many cad quality testers still unaffordable small medium enterprises terms cost training time interoperability reasonably solved standards like step model reusability feasible explicit representations procedural representations promising interactive modeling editors automatically prevent morphologic errors derived unsuitable modeling strategies interoperability problems procedural representations expected decrease dramatically step higher semantic aspects quality assurance design intent however hardly supported current cad quality testers elsevier ltd rights reserved
thermoelectric materials convert waste heat electricity received increasing research interest recent years paper describes recent progress thermoelectric nanocomposites based solution synthesized nanoheterostructures start discussion strategies improving power factor given material using nanoheterostructures discuss methods decreasing thermal conductivity finally highlight way decoupling power factor thermal conductivity namely incorporating phase transition materials nanowire heterostructure explored lead telluride copper telluride thermoelectric nanowire heterostructure work future possible ways improve figure merit discussed end paper
construct quintic quasi topological gravity five dimensions theory lagrangian containing terms whose field equations second order spherically hyperbolic planar symmetric spacetirnes theories recently received attention since formulated asymptotically ads spacetimes might provide gravity duals broad class simplicity focus five dimensions show theory fulfils birkhoff theorem case lovelock gravity therefore generic values couplings wave propagating mode prove spherically symmetric solution determined quintic algebraic polynomial equation resembles wheeler polynomial lovelock gravity black hole solutions compute temperature mass entropy show first law black holes thermodynamics fulfilled besides fourth order general show field equations linearized around ads second order therefore theory propagate ghosts around background besides class theories originally introduced arxiv general geometric structure lagrangians remains open problem
iraq experiencing water resource shortages expected become severe future believed rainwater harvesting one solutions overcome problem paper rainwater harvest modeling techniques applied sinjar area northwest iraq agricultural purposes watershed modeling system wms linear programming optimization techniques applied maximize irrigated area could supplied selected reservoir period technique proved efficient solving large scale water supply problems multiple parameters constraints including required input data model two scenarios operation considered main basin first reservoir operated separate unit second reservoirs within basin operated one system scenarios gave encouraging results scenario provided better results
investigation paper three dimensional gross pitaevskii equation distributed time dependent coefficients describes phenomena associated three dimensional bose einstein condensation constraint alpha beta obtain bilinear forms dark bright soliton solutions via hirota method symbolic computation scaled time coefficients strength quadratic potential diffraction respectively specially compared bright soliton solutions previously reported eliminate one constraint obtain soliton parameters give existence constraints dark bright solitons respectively choosing diffraction gain loss coefficients observe growth decay periodic oscillation periodic collapse revival dark bright solitons relationships bec time dependent coefficients soliton properties studied help asymptotic graphic analysis elastic interactions dark bright two solitons exhibited elsevier ltd rights reserved
sgml standardized iso international organization standardization proliferated provide various styles transform documents different platforms sgml document logical structure information addition contents sgml documents widely used increasing demand storage retrieval system use logical structure documents efficiently however traditional retrieval systems based document indexes exploit logical structure appropriately paper developed document storage retrieval system based structure information sgml document transformed grove document model dsssl hytime stored element level object oriented dbms object store supports structured documents provides query interface retrieve information contained structures elsevier science ltd rights reserved
topology interconnection networks plays important role performance parallel distributed computing systems paper propose new interconnection network called twisted crossed cube tcq investigate basic network properties terms regularity connectivity fault tolerance recursiveness hamiltonicity ability simulate architectures develop effective routing algorithm route tcq takes steps two nodes communicate routing process shows diameter wide diameter fault tolerant diameter tcq half corresponding diameters equivalent hypercube dimension end combining tcq crossed cube propose preferable dynamic network structure dynamic crossed cube network diameter tcq better properties respects example connection complexity half tcq network scale large enough number average routing steps also much smaller tcq copyright john wiley sons ltd
definition description student success programs literature orientation first year seminars learning communities etc suggest underlying programmatic similarities yet researchers date typically depend ambiguous labels delimit studies resulting loosely related separate research lines generalizable findings demonstrate whether certain programs effective need coherent conceptualizations identify describe programs particularly problematic community colleges success programs uniquely tailored relative sectors study purpose derive empirical typology community college student success programs based curricular programmatic features data come success programs based respondents community college institutional survey programs might characterized focus different curricular areas combinations foci used factor mixture modeling hybrid factor analysis latent class analysis provides model based classification method simultaneously accounts dimensional categorical data structures descriptive findings revealed extensive commonalities among nominal program types inferential analysis revealed five factors types program elements combined unique ways among four latent program types success skills programs comprehensive programs collaborative academic programs minimalist programs illustrate typology deconstructs nominal categories may help unify different bodies research affords common framework language researchers practitioners identify conceptualize programs based rather names
database auditing one biggest issues data security absence information auditing drives business applications lost trail business procedures cope auditing order track operations actors operations time need historical data temporary database legitimate exchange times two important time stamps temporary database paper show methods handle database auditing business exchange operations accurate times performers operations strategies separated two sets utilizing relational databases utilizing semi structured information
paper presents overview use goal oriented strategies output based aid oba payment environmental services pes water pollution abatement control urban rural areas throughout country thus considering goal implementing iwrm two nation wide experiences reviewed river basin clean program prodes water producer program run national water agency ana former initiated decade ago illustrate successful ways bring public authorities water users together case sanitation services landowners respectively finally discussed applicability perspectives carrying new goal oriented initiatives aimed iwrm brazil
research indicates stereotypes intersect example intersection stereotypes gender mental disorders could result perceptions gendered mental disorders current research studies showed people view specific disorders masculine feminine masculine stereotype included antisocial personality disorder addictions paraphilias feminine stereotype included eating disorders histrionic personality disorder body dysmorphia orgasmic disorder studies perception disorders masculine positively correlated stigma study showed positive correlation masculinity stigma also occurred examining specific symptoms rather full mental disorders findings provide evidence intersection stereotypes indicate novel factor understanding stigma
global growth geosynthetics last decades substantially enhancing average per annum within domain geotextile jute geotextile jgt class natural technical textile carved niche emerging technology though far behind man made counterpart growth effectiveness addressing host different geotechnical problems importantly eco congruity gaining increasing acceptability worldwide major uses jgt road construction low medium volume roads particular soil erosion control etc traditional sacking quality jute woven fabrics plain twill weaves used mentioned applications use conventional jute sacking fabrics application specific function oriented deserves rethinking adoption conventional jute fabrics used flexible packaging road construction soil erosion control well geotechnical construction context development potentially important jgt strengthening rural roads well river bank protection assumes significance realized jgt woven whose property parameters functionally apt serving purpose paper outlines structured approach fabric engineering related jgt tune different prime parameters design concerning rural road construction river bank protection along optimization standardization fabric comparative analysis different tests results property parameters developed jgt samples
landscape aesthetic dermatology changed dramatically past couple years due soaring patient demands minimally invasive safe effective fast whole body procedures continuously emerging new technologies moreover concept whole body rejuvenation new paradigm ensures skin health age prophylaxis stimulating dermal remodeling epidermal turnover skin tightening modulating repletion depletion volume requires clinical application combination energy based devices intense pulsed light fractional lasers vascular lasers ultrasound radio frequency shockwave low energy laser light devices alongside fillers toxins home skin care regimen present day reality mobilized physicians carefully assess best strategies patient goals capitalizing advantages technologies entering arena report aims provide overview mainstream energy based modalities currently used whole body rejuvenation
mothers children often experience negative outcomes following unintended pregnancies current study examined conditions unintended pregnancy associated negative outcomes among sample first time mothers recruited part predicting preventing child neglect teen mothers study specifically maternal demographic characteristics examined moderators association pregnancy intention parenting behaviors children months old results revealed unintended pregnancy associated fewer positive parenting behaviors however maternal race education moderated association among mothers identified black hispanic intended get pregnant less likely demonstrate positive parenting behaviors less education tended demonstrate fewer positive parenting behaviors regardless pregnancy intention implications research prevention intervention discussed
backgroundthe trigeminal autonomic cephalalgias tacs highly disabling primary headache disorders several issues remain unresolved understanding pathophysiology tacs although activation trigeminal autonomic reflex ipsilateral hypothalamic activation play central role discovery central role hypothalamus led use therapeutic target good results obtained hypothalamic stimulation peripheral neuromodulation targets tried management refractory cluster headache tacs methodsthis review summary pathophysiology efficacy different neuromodulation techniques resultsin chronic cluster headache cch patients hypothalamic deep brain stimulation dbs produced decrease attack frequency patients occipital nerve stimulation ons also elicited favorable outcomes reduction attacks around patients medically intractable cch stimulation sphenopalatine ganglion spg miniaturized implanted stimulator produced clinically significant improvement patients acute preventive vagus nerve stimulation vns portable device used conjunction standard care patients resulted reduction number attacks dbs ons used successfully cases tacs including hemicrania continua short lasting unilateral headache attacks sunha conclusionsdbs good results invasive technique generate serious adverse events ons good results frequent serious adverse events spg stimulation spgs also efficacious acute prophylactic treatment refractory cluster headache moment ons spg stimulation techniques recommended first line therapy refractory cluster patients new recent non invasive approaches non invasive vagal nerve stimulator nvns shown efficacy trials could interesting alternative management require testing positive randomized controlled trials
new solar biomass power generation system integrates two stage gasifier proposed paper system two different types solar collectors concentrating solar thermal energy different temperature levels applied drive solar biomass thermochemical processes pyrolysis gasification production solar fuel produced solar fuel namely gasified syngas directly utilized advanced combined cycle system power generation numerical simulations implemented evaluate design design thermodynamic performances system results indicate proposed system achieve overall energy efficiency net solar electric efficiency nominal condition proposed two stage solar biomass gasification routine exhibits improved system thermodynamic performance compared one stage gasification technical mode provided heat resource good match requirements biomass gasification procedure given simulation conditions paper energy level upgrade ratio proposed two stage solar biomass gasification system introduced solar thermal energy high compared one stage gasification mode meanwhile daily average net solar electric efficiency representative days reaches range one stage model research findings provide promising approach efficient utilization abundant solar biomass resources western china reduction emission published elsevier ltd
background evaluate compare effectiveness combined regimen consisting condoms emergency contraception pills ecp using condoms purpose preventing pregnancy methods one thousand five hundred sixty two couples volunteers enrolled nine centers shanghai eight hundred twelve randomized use male condoms ecp levonorgestrel back condoms intervention group use male condoms control group according working unit participants visited admission end months cumulative life table rates calculated pregnancy reasons discontinuation result gross cumulative life table rates showed cumulative discontinuation rates reasons year follow condoms plus emergency contraception group condoms group respectively per women chi cumulative gross pregnancy rate condoms plus emergency contraception group condoms group respectively per women chi pearl index condoms plus emergency contraception group condoms group respectively conclusion male condoms remain highly effective contraceptive method period one year consistently correctly used addition lowest pregnancy rate followed perfect use condom
background recurrent respiratory tract infections rrtis common reason children visits primary care physicians france however little known general practitioners gps opinions expectations concerning management prevention common recurrent pathologies purpose describe french gps daily practice management respiratory infections prevention recurrence children methods sample group french gps answered structured questionnaire risk factors rrti management antibiotic use prevention measures results total gps participated survey rhinopharyngitis frequent respiratory infection considered recurrent six episodes occurred year four risk factors acknowledged substantial living communities passive smoking pollution allergies around gps said rrtis often treated antibiotics thought prevention rrtis possible smoking cessation vaccination allergen avoidance hygiene identified main preventive measures large majority gps prescribed products prevention similar would prescribe product stimulating immunity efficacy tolerability agents proven confirmed daily practice conclusions french gps well aware health socioeconomic burdens resulting rrtis well risk antibiotic overuse prevention oriented approach implement preventive measures possible prescribe products prevention
lysine crotonylation histones recently identified post translational modification demonstrated associate active promoters directly stimulate transcription given crotonyl coa essential acyl transfer reaction metabolic intermediate widely localized within cell postulate lysine crotonylation nonhistone proteins could also widely exist using specific antibody enrichment followed high resolution mass spectrometry analysis identified hundreds crotonylated proteins lysine residues bioinformatics analysis reveals crotonylated proteins particularly enriched nuclear proteins involved rna processing nucleic acid metabolism chromosome organization gene expression furthermore demonstrate crotonylation regulates hdac activity expels alpha heterochromatin inhibits cell cycle progression phase data thus indicate lysine crotonylation could occur large number proteins could important regulatory roles multiple nuclei related cellular processes
nowadays tuition control engineering courses usually obligatory students attending technical universities unimaginable without passing practical part laboratories set ups laboratories undergone evolution instead demos real industrial control solutions small scale laboratory models increasing interest paid tasks presenting control problems attractive models invoking natural interest heuristic mastering specially designed model devices linked pcs order provide realistic hmi course internet aim paper short presentation set ups names characterizing demonstrated activity addition wish present experience application various technologies used creating virtual version tasks virtual versions try true computer copies real models makes possible preliminary preparation students given task certain confrontation results obtained reality carrying similar similar experiment place laboratory remote access via internet ifac international federation automatic control hosting elsevier ltd rights reserved
paper digital architecture generating piecewise linear arbitrary waveforms presented proposed design able generate piecewise linear periodic signal using minimum number input data breakpoints generator circuit implements hybrid scheme takes advantage two methods purely piecewise linear interpolation lookup table structure piecewise linear method exploits characteristic reduced memory requirement well capability automatically construct waveform repetitive iterative function evaluations lookup table makes use simplicity hardware implementation higher processing speed order verify performance proposal three piecewise linear waveforms successfully implemented atmega microcontroller experimental results show fast execution speed reduced memory demand proposed circuit realization
background aims ledipasvir sofosbuvir combination treatment phase iii clinical trials resulted sustained viral suppression patients study characterized drug resistance treatment failures may help inform retreatment options methods performed nsa nsb deep sequencing hepatitis virus hcv patients infected genotype participated ledipasvir sofosbuvir phase iii clinical trials results fifty one gta gtb treated patients met criteria resistance analysis due virologic failure following end treatment majority patients virologic failure detectable ledipasvir specific resistance associated substitutions rass time virologic failure deep sequencing cut percent patients nsa rass virologic failure patients treated weeks respectively common substitutions detected failure gta gtb failure virologic failure patients viruses two nsa rass majority patients harbored nsa rass conferring fold fold reduced susceptibility ledipasvir one patient phase study known ledipasvir ras baseline developed sofosbuvir nsb ras failure conclusions hcv infected patients treated ledipasvir sofosbuvir ribavirin virologic failure rare ledipasvir resistance nsa selected enhanced patients virologic failure one also developed resistance sofosbuvir lay summary clinical studies shown combination treatment ledipasvir sofosbuvir efficiently cures patients genotype hepatitis infection patients failing treatment show resistance ledipasvir observed patients whereas resistance sofosbuvir less common important implications selection optimal retreatment strategies patients european association study liver published elsevier rights reserved
paper study two stage stochastic linear programming slp problems fixed recourse problem often large scale objective function involves expectation discrete set scenarios paper presents parallel implementation augmented lagrangian method solving slps parallel method based modified version shaped method reducing linear master recourse programs unconstrained maximization concave erentiable piecewise quadratic functions maximization problem solved using generalized newton method parallel method implemented matlab large scale slp several millions variables several hundreds thousands constraints solved results uniprocessor multiprocessor computations presented show parallel algorithm ective
last decade environmental imperatives found way new zealand debate quality performance built environment new zealand green building council launched green star office design soon complemented office built tool however actual performance green star rated buildings seldom verified occupation dissimilar common practice office buildings high proportions unshaded glazing lightweight structures air conditioning systems raises legitimate questions overall indoor air quality comfort efficacy rating tool actually delivering assessed quality paper examines overall features green star rated office buildings auckland discusses measured performance two case study buildings one naturally ventilated one air conditioned comparing indoor air quality comfort results first research phase reveal clear discrepancies predicted measured performance localized thermal comfort issues naturally ventilated building due design failures human behaviour also indicate need adjustments rating tool order increase sensitivity different ventilation systems
coarctation aorta coa reported associated increased risk migraine describe case year old female patient presented migraine aura surgical repair coa stent possible reasons condition postulate host responses stent placement disturbed cerebral autoregulation related intracranial hypertension surgical repair hypotension afterward leading hypoperfusion case demonstrates novo migraine aura occur surgical repair coa recognized potential complication
network security problem paper proposes kind loose security protocol algorithm protocol includes two parts authentication encryption respectively used authentication encryption network applications paper also adopts opnet customize application modeling method order analyze network performance protocol algorithm simulation shows analysis optimization algorithm performance customizing application model using opnet design loose security protocol algorithm algorithm performance significant improvement
introduction human embryonic stem cells hesc provide invaluable model assessing effects environmental chemicals drugs human prenatal development however hesc difficult adapt well plate screening assays survive best plated colonies difficult count plate accurately purpose study present experimental method analysis procedure accomplish reliable screening toxicants using hesc methods present method developed rapidly easily determine number cells small colonies hesc spectrophotometerically accurately dispense equivalent numbers cells well plates mtt assay used evaluate plating accuracy method tested using known toxicants results quality plate set analysis procedure evaluated nih plate validation assessment software statistical parameters measured software acceptable drift edge effects observed well plate mtt assay hesc tested performing dose response screen commercial products contain variety chemicals screen done using single wells dose reliability method demonstrated subsequent screen products repeated three times single triple screens good agreement noaels could determined single screen effects vapor volatile chemicals studied methods monitor avoid vapor effects incorporated assay discussion method overcomes difficulty using hesc reliable quantitative well plate assays enables rapid dose response screening using equipment commonly available laboratories culture hesc method could broad application studies environmental chemicals drugs using hesc models prenatal development elsevier inc rights reserved
wearable devices emerged last years new applications provide user convenience healthcare sports safety examples applications embedded thousands devices released last years wearable operating systems different focus emerged together wearable applications order make adjustments optimizations software hardware paper presents wearable operating systems discussion shows current challenges wearable operating system influence developed wearable appliance geology wearable contains head mounted display hmd assembled google cardboard api sensors connected developments boards system component used different operating systems according hardware software available results indicate trends wearable operating systems
objectives pantomiming use familiar tools central test assessment apraxia however surprisingly nature underlying cognitive mechanisms remains unresolved issue aim study shed new light issue exploring role functional mechanical manipulation knowledge patients alzheimer disease semantic dementia apraxia tool use methods performed multiple regression analyses global performance nature errors production conception made pantomime tool use task patients control participants dependent variables tasks investigating functional mechanical manipulation knowledge predictors results found mechanical problem solving assessing mechanical knowledge good predictor global performance pantomime tool use also found occurrence conception errors robustly predicted task assessing functional knowledge whereas production errors explained one predictor conclusions results suggest functional mechanical knowledge important pantomime use tools knowledge first demonstration mechanical knowledge plays role pantomime tool use although impairment pantomime tool use tasks apraxia widely explained disruption manipulation knowledge propose pantomime tool use complex problem solving task
prior research measures gender role attitudes among christians however measures generally limited societal familial contexts little prior research examined gender role attitudes conservative christian religious contexts research focused religious contexts qualitative uses simple measures validated therefore present paper presents data two national samples describing psychometric properties attitudes toward gender roles conservative christian contexts scale ways scale used measure adherents gender role attitudes congregational settings addressed
introduction non coeliac gluten wheat sensitivity ncg syndrome characterized intestinal extra intestinal symptoms occurring hours days ingestion gluten wheat proteins patients testing negative coeliac disease wheat allergy areas covered present review deals recent scientific acquisitions gluten related syndrome including pathogenetic mechanisms clinical picture symptom score biomarkers double blind placebo controlled trial diagnosis treatment methodology used literature search ncg using medline premedline august expert commentary discussed pathogenesis symptom generation altered gut physiology ncg possible mechanisms include innate adaptive immune activation impaired intestinal epithelial barrier changes gut microbiome interlinked factors may exploited clinical relevance possible biomarkers systemic immune response microbial wheat antigens together intestinal cell damage occurs patients ncg due lack established biomarkers mandatory validate diagnosis syndrome means well defined work involving dietary challenge finally dietary therapeutic indications thoroughly reviewed
background transcranial magnetic resonance guided focused ultrasound emerging technology evaluation treatment essential tremor prevalent movement disorder qualitative evaluation performed clinician periodically procedure maximize treatment effects minimize adverse effects present work demonstrates magnetic resonance compatible method enable precise quantitative measurement tremor severity methods tremor severity measured patients pre post intra operatively using magnetic resonance compatible tablet computerized adaptation drawing tasks widely used fahn tolosa marin tremor rating scale tremor metrics based spectral analysis calculated drawing compared using wilcoxon signed rank tests results tremor metrics dominant treated hand significantly consistently lower post operatively compared pre operatively significant difference non dominant untreated hand expected intra operative metrics intermediate pre post operative metrics conclusions use tablet quantitative tremor measurement demonstrated pre post intra operatively treatment essential tremor complementing standard qualitative assessment additional work system potential add objectivity clinical trials aid treatment decision making providing metric optimization procedure may eventually lead optimal treatment enhancements studies suggested extensions fmri studies essential tremor parkinson disease also likely
study evaluated effectiveness group parenting intervention designed strengthen home learning environment children disadvantaged families two cluster randomised controlled superiority trials conducted parallel delivered within existing services week parenting group locations randomised parents parents infants aged months week facilitated playgroup locations randomised parents parents toddlers aged months trial three conditions intervention smalltalk group enhanced intervention home coaching smalltalk plus standard usual practice controls parent report observational measures collected baseline weeks follow primary outcomes parent verbal responsivity home learning activities weeks infant trial differences trial arm primary outcomes weeks toddler trial weeks participants smalltalk group trial showed improvement compared standard program parent verbal responsivity effect size home learning activities smalltalk plus secondary outcomes infant trial several initial differences favouring smalltalk plus evident weeks maintained weeks toddler trial differences secondary outcomes favouring smalltalk plus evident weeks maintained weeks trials provide evidence benefits parenting intervention focused home learning environment parents toddlers infants trial registration september actrn
paper novel adaptive synchronous rectification method digitally controlled llc converters proposed sensing synchronous rectifier body diode forward drop turn turn edges optimized efficiency negative current prevention utilized improve system robustness enhanced simple digital control capabilities compared conventional analog control approach method achieves higher system efficiency flexibility control method implemented texas instruments digital power controller ucda companion gate driver ucd
many assessment measures validated one specific diagnostic population costly reduces clinical utility assessments eyberg child behavior inventory ecbi one popular measure designed assess disruptive behavior problems youth ecbi sound psychometric properties typically developing youth factor structure never examined children autism spectrum disorder asd therefore current study conducted comprehensive psychometric analysis ecbi children asd retrospective data nationally representative sample collected children asd ages years old four factor solution identified sample implications findings directions future research discussed
headache one frequently reported symptoms following traumatic brain injury tbi little known headaches change time describe natural history headache individuals moderate severe tbi years injury total patients prospectively enrolled followed months injury individuals male white injured motor vehicle crashes average age pre injury headache reported individuals new worse headache prevalence remained consistent least time points incidence time points first report new worse headache participants months disability related headache high average headache pain scale ranging baseline months post injury reports substantial impact daily life across time points half classifiable headaches matched profile migraine probable migraine headache substantial problem tbi results suggest ongoing assessment treatment headache tbi needed symptom may problem years post injury
traffic sign recognition tsr integrated part driver assistance systems remains active research topic computer vision today paper proposes solution tsr problem composed robust traffic sign image descriptor sparse classifiers specifically outline variant histogram oriented gradients hog namely soft hog shog exploits symmetry shape traffic sign images find optimal locations cell histogram shog computation show compact shog feature discriminative hog furthermore two sparse analytical polynomial based classifiers namely sparse bayesian multivariate polynomial model sparse bayesian reduced polynomial model introduced proposed sparse classifiers enable implicit feature selection alleviate overfitting problem leads higher accuracy performance prudent set features solution evaluated publicly available german traffic sign recognition benchmark gtsrb dataset datasets uci repository experiment results demonstrated proposed method satisfactory result compared state art methods elsevier rights reserved
describe general framework generating invariant inference procedure invariant checking procedure given checker language possible invariants generates inference procedure iteratively invokes two phases search phase uses randomized search discover candidate invariants validate phase uses checker either prove refute candidate actual invariant demonstrate applicability use generate inference procedures prove safety properties numerical programs prove non termination numerical programs prove functional specifications array manipulating programs prove safety properties string manipulating programs prove functional specifications heap manipulating programs use linked list data structures
new forest parenting programme nfpp parenting program developed parents child attention deficit hyperactivity disorder adhd manualized program delivered parent home weeks group format self help manual three randomized controlled trials carried united kingdom nfpp group adapted program according feedback parents therapists use different populations within united kingdom internationally first international trial took place new york united states trials denmark hong kong japan followed recently trial self help manual carried mainland china paper outline adaptions needed order able deliver program different countries expectations parenting culture language training differently focused manuals handouts revised translated back translated supervision delivered distance maintain fidelity program international group outline experience running trials countries nfpp face face format denmark group format hong kong japan self help format mainland china
despite increasing rates university attendance among women significant gender gap remains socialisation educational processes japan understand gender distinctive socialisation processes persist study aimed examine middle class working class mothers beliefs gender education children development qualitative analyses conducted depth interviews japanese mothers preschool children participated research study three years meaning education differed depending children gender social class context social class difference mothers expectations daughters educational attainment majority women study saw daughters caregivers family members future study also demonstrates dilemmas mixed messages women narratives relation gender norms processes raising children
method constructing time domain models including drude materials finite element data frequency domain presented produce model compact projection based order reduction techniques applied time domain model based state space representation proven passive causal moreover suggested approach provides efficient way reconstructing transient electromagnetic fields
using turkish portion programme international student assessment dataset boys girls age years study investigated factors associated mathematics achievement among turkish students three different models estimated using method balanced repeated replication fay method taking account presence five plausible values dependent variable results showed male students older students better mathematics proficiency socio economic status school resources also played significant role explaining student achievement mathematics finally students open problem solving attributed failure external factors intrinsically motivated learn mathematics achieved higher scores policy implications provided
current centralized urban water supply depends largely energy consumption creating critical water energy challenge especially many rapid growing asian cities context harvesting rooftop rainwater non potable use enormous potential ease worsening water energy issue propose geographic information system gis simulation based design system gsbds explore rainwater harvesting systems rwhss systematically cost effectively designed innovative water energy conservation scheme city scale gsbds integrated rainfall data base water balance model spatial technologies energy saving investigation economic feasibility analysis based case study eight communities taipei metropolitan area taiwan addressing temporal spatial variations rainfall gsbds enhanced broad application rwhs evaluations results indicate scheme feasible based optimal design water energy savings evaluated rwhss observed cost effective facilitated domestic water use savings kwh year family energy savings furthermore cost per unit energy saving lower solar systems rwhs settings hence rwhss enable water savings also alternative renewable energy saving approach address water energy dilemma caused rapid urbanization
producing software systems achieve acceptable tradeoffs among multiple non functional properties remains significant engineering problem propose approach solving problem combines synthesis spaces design alternatives logical specifications dynamic analysis point resulting spaces hypothesize approach potential help engineers understand important tradeoffs among dynamically measurable properties system components meaningful scales within reach existing synthesis tools test hypothesis developed tools enable conducted set experiments domain relational databases object oriented data models several data models used approach empirically test accuracy published suite metrics predict tradeoffs based static schema structure alone results show exhaustive synthesis analysis provides superior view tradeoff spaces designs work creates path forward toward systems achieve significantly better tradeoffs among important system properties
background persons multiple sclerosis pwms often characterized increased motor fatigability performance change objectively measured criterion type voluntary muscle contractions review summarizes existing literature determine protocols outcome measures best detect study motor fatigability underlying mechanisms methods two electronic databases pubmed web science searched relevant articles published august combination multiple sclerosis fatigability muscle fatigue motor fatigue results total articles retained data extraction variety fatigability protocols reported protocols showed differences type isometric concentric duration number contractions fixed exhaustion also articles reported motor fatigability functional movements predominantly assessed changes walking speed studies evaluated mechanisms underlying motor fatigability using additional electrical nerve transcranial magnetic stimulation three articles reported psychometrics outcomes conclusions disparity protocols outcome measures study different aspects motor fatigability pwms impedes direct comparison data protocols use maximal single joint isometric contractions advantage high standardization head head comparison different protocols limited information psychometric properties outcomes currently gold standard assess motor fatigability disability level disease phenotype studied limb may influence assessment motor fatigability pwms
problem vehicle lateral stability control fully electric vehicles addressed paper using two different approaches one novel integrated lateral stability control ilsc system second one regenerative braking based lateral stability control system lsc proposed ilsc system based corrective yaw moment calculation braking torque distribution electric motor torque reduction proposed second method lsc simpler method ilsc system method electric motor torque regulated according vehicle side slip error vehicle yaw rate error performances proposed methods evaluated severe road conditions extreme maneuvers using commercially available carsim vehicle dynamics software results show proposed control systems improve vehicle lateral stability significantly
pathophysiology prolapse well understood however two main theories predominate either fibromuscular layer vagina develops defect tears away supports tissues stretched attenuated aim study assess vaginal wall thickness vwt related vaginal prolapse study group comprised women symptomatic prolapse recruited outpatient department tertiary referral centre urogynaecology history taken women examined determine pop score using previously validated technique ultrasonography used measure mean vwt three anatomical sites anterior posterior walls scores compared using tests kruskal wallis test friedman test mean age patients years years range years measurement vwt reduced prolapse grade increased prolapse extended beyond hymen women grade prolapse significantly higher mean vwt women grade contained prolapse menopause status significant effect vwt vwt lower women vaginal prolapse prolapse extends beyond hymen vwt thicker comparable women without prolapse may explained changes vaginal tissue including reduction collagen elastin smooth muscle well fibrosis exposed tissues rather defects vagina
thermostatically controlled loads tcls perform demand response services real time markets online methods parameter estimation needed physical characteristics tcl change contents refrigerator occupancy conditioned room necessary update parameters tcl model otherwise tcl incapable accurately predicting potential energy demand thereby decreasing reliability tcl aggregation perform demand response paper investigate potential various unscented kalman filter ukf algorithm variations recursively identify tcl model non linear parameters experimental results demonstrate parameter estimation two residential refrigerators finally simulation results demonstrate incorporation recursive parameter estimation methods model predictive controller demand response elsevier ltd rights reserved
rate bone loss important risk factor fracture studied longitudinal changes bone mineral density bmd although bmd hip decreased time spine bmd remained largely stable increased therefore spine bmd may appropriate assessing bmd change rate age dependent bone loss shown important risk factor fracture however longitudinal rates bmd loss korea yet reported objective study evaluate longitudinal changes bmd korea cohort study performed population individuals years age older living rural area chungju city korea second bmd examination conducted approximately years baseline examination total subjects completed follow visit corresponding follow rate age standardized osteoporosis prevalence males females males average annual bmd loss total hip increased per year per year females average annual bmd loss total hip increased per year per year however average annual percentage change spine bmd females increased per year per year substantial number subjects osteoporosis even though standardized prevalence osteoporosis total hip mean bmd decreased follow period addition annual percentage loss increased age however spine bmd remained approximately stable increased time therefore may appropriate assessing bmd change
scintillations rapid fluctuations phase amplitude satellite radio signals travelling ionosphere caused time varying electron density irregularities scintillations considerable effect performance positioning quality global satellite navigation systems gnss may reduce accuracy pseudo range phase measurements even cause loss lock signal paper discuss tools development monitor occurrence scintillation assess impact final positioning quality fugro worldwide network gnss stations network stations operated university nottingham
gauging one impression potential mate challenging need make reasonably accurate inferences subtle dynamic facial expressions maintain motivation connect despite risk rejection interpersonal optimism people low rejection sensitivity people confidently expect acceptance rather anxiously expect rejection high counterparts suggests may strategically underestimate social threat cues inferring impression made others test hypothesis participants viewed videotaped reactions individuals said read participant someone else biographical sketch online dating context estimated emotions targets estimates negativity unrelated participants believed videos captured reactions someone else biographical sketch however extent participants low made lower estimates negativity believed videos showed reactions biographical sketch compared believed videos captured reactions someone else biographical sketch tracking accuracy participants estimating negativity unrelated either condition increased trait empathy unrelated estimates positivity supporting functional perspectives interpersonal perception results show interpersonal optimism shapes impressions others reactions self ways foster relationship initiation
paper exploit lottery tanzania randomly assigned eligible participants receive cash grants randomized nature lottery allows estimate causal impact positive income shocks risky sexual behavior found winning lottery led men sexual partners increase probability unprotected sex non primary partner relative control group eligible non winners found significant effect winning lottery sexual behavior women
least mean magnitude phase lmmp algorithm useful complex valued signal processing applications control magnitude phase error information needed achieve good overall performance due highly nonlinear nature update terms lmmp related methods convergence stability results exist guide step size choices algorithms paper provide rigorous stability convergence analysis lmmp algorithm using robustness procedures give sufficient stability conditions magnitude phase step sizes guarantee contraction mapping behavior also provide approximate relation steady state mse function step size values simulations verify predictive powers analytical results yield useful insights step size choices practice
young men transition adulthood may time heightened adherence traditional gender roles norms masculinity however recent research young men gender specific contexts indicated contexts support construction masculinity inclusive theoretical thematic analysis interviews young men first week male trade school explored participants talked gender role lives discussions gender may reflect individual gender ideologies discussions may inform participants experiences particular developmental contexts themes identified included following becoming man active process experiences male embodiment size strength intersections school identity man students perceptions male school environment means female classmates reflections parts see feminine discuss implications findings future research adolescents young adults relation gender relationships professional development
key value stores become backbone large scale applications today data centers writeoptimized data structures like log structured merge tree lsm tree variants widely used storage systems like bigtable rocksdb conventional lsm tree organizes items multiple successively larger components uses compaction push items one smaller component another adjacent larger component items reach largest component unfortunately current compaction scheme incurs significant write amplification due repeated item reads writes results poor throughput propose new compaction scheme delayed compaction dcompaction decreases write amplification dcompaction postpones compactions gathers following compaction way avoids item reads writes compaction consequently improves throughput lsm tree based stores implement dcompaction rocksdb conduct extensive experiments validation using ycsb framework shows compared rocksdb dcompaction write performance improvements also comparable read performance
rheumatoid arthritis chronic autoimmune disease significant morbidity mortality costs individual patient society purpose study examine welfare costs patients including partners initial diagnosis data collected population based registers period total danish patients diagnosis partners identified compared randomly selected age gender matched controls control partners direct indirect costs calculated patients partners compared matched controls included inpatient outpatient treatment medication income employment social transfer payments patients statistically significantly inpatient outpatient costs control subjects treatment notsign notsign hospitalization notsign notsign medication use notsign notsign costs associated patients present years diagnosis notsign compared control subjects notsign furthermore income employment lower patients notsign control subjects notsign partner patient associated high total welfare costs register based study shows significant welfare costs patients partners society differences total health costs exist years diagnosis established
cancer stem cells cscs tumor initiating cells tics small subset neoplastic cells able produce tumor tumorigenesis maintain population tumorigenic cells self renewal generate heterogeneous cells constructing entire tumor pluripotency research stationary circulating cscs due resistance conventional therapies inability complete eradication cancer critical developing novel therapeutic strategies effective reduction risk tumor metastasis cancer recurrence review compiles information different methods detection dissociation side population cellular markers establishment culture cscs well characteristics cscs tumorigenicity signaling pathways associated self renewal capability histological tumor regeneration various cancers
important potential learning system ability adapt based learner status order support personalized learning however requires using specific learner parameters factors control adaptation process include learning style presentation preferences progress preference subject paper presents web based tutoring system support students learning computer programming novelty system using cognitive process levels revised bloom taxonomy factor adaptation learner progress system moves learner simple levels complex ones
ethnopharmacological relevance periploca forrestii schltr classical traditional chinese medicine tcm called heilonggu hlg china according theory tcm possesses efficacy eliminating wind removing dampness clinical practice commonly used treatment rheumatoid arthritis present work aimed evaluate anti rheumatism activity hlg ethanol extract reveal underlying molecular mechanism employing animal model collagen induced rheumatoid arthritis cia rats materials methods cia induced male sprague dawley rats intradermal injection bovine collagen complete freund adjuvant cfa base tail rats received oral administration hlg day treatment lasting days variety indicators measured evaluation anti rheumatism effect including paw swelling arthritis scores histopathological changes furthermore serum levels tumor necrosis factor alpha tnf alpha interleuldn prostaglandin pge well cyclooxygenase cox nuclear factor kappa src kinase joint synovial tissues detected explore possible mechanisms results administration hlg significantly restored type collagen induced arthritis rats evidenced decrease paw swelling inflammatory factors serum meanwhile treatment also notably reduced kappa cox expression surprisingly activity src kinase also inhibited demonstrated downregulation phosphorylated src conclusion results revealed hlg possessed observable therapeutic action collagen induced arthritis inhibiting activation src nuclear translocation kappa rats hlg may serve potential candidate management patients
power generation biomass gasification use spark ignition engines requires cooling biomass syngas avoid knock cooling leads condensation tar impurities foul clog critical process components leading significant maintenance issues costs conventionally tar related problems addressed optimizing gasification process along developing tar purification systems result increased investment maintenance costs novel method developed universite catholique louvain entire process exit biomass gasifier combustion tar loaded impure syngas internal combustion engine carried temperature degrees thereby avoiding tar condensation consequent problems homogeneous charge compression ignition hcci engine utilized high intake temperature operation paper describes first experiments impure hot biomass syngas produced two stage gasifier burned hcci engine without intermediate cooling tar purification steps objective experiment test stability engine response naturally occurring random variations syngas composition experiments carried continuous period indicated efficiencies imep around bar observed emissions nox relatively high probably due presence ammonia syngas implementation closed control loop combustion phasing feedback parameter fueling rate controlled parameter ensured stable operation experimental duration elsevier rights reserved
objective unusual clinical course background systemic lupus erythematosus sle multisystem autoimmune disorder unknown etiology present age symptoms mucocutaneous musculoskeletal renal central nervous system nonspecific clinical pictures making disease master mimicry case report year old female recently diagnosed sle presented right sided sharp electric shock like facial pain starting side right nostril traveling naso labial fold back angle jaw mostly region distribution radiation beyond trigeminal distribution pain going last years regarded pretrigeminal neuralgia however progressed frequency last weeks clear identifying triggering factors laboratory test results showed positive anti nuclear antibodies ana raised titer anti double stranded dna anti ribonucleoprotein anti sjogren syndrome related antigen anti sjogren syndrome related antigen anti smooth muscle antibodies possibilities migraine postherpetic neuralgia bell palsy brain tumor ruled diagnosis sle trigeminal neuralgia made carbamazepine times day prescribed conclusions seldom mentioned neurological manifestation sle hence recommend studies investigate sle mediated injury trigeminal fibers make timely diagnosis prevent progressive autoimmune process related vasculitic demyelinating changes
toxoplasma gondii suggested important opportunistic pathogen immunocompromised patients conducted global meta analysis assess prevalence odds ratios ors gondii infection immunocompromised individuals electronic databases reviewed gondii infection hiv aids patients cancer patients transplant recipients meta analyses conducted calculate overall estimated prevalence ors using random fixed effects models totally eligible studies included estimated pooled prevalence gondii infection immunocompromised patients control hiv aids patients control cancer patients control whose estimated pooled ors respectively study first demonstrate immunocompromised patients associated higher odds gondii infection appropriate prevention control measures highly recommended susceptible populations
paper describes learning parallel constraint programming solver designed solving problems several instances massively parallel computing platforms comprising multi core parallel machines many integrated cores solver proposed work based portfolio parallelization employs linear reward inaction learning algorithm order obtain best possible performance large set instances problem linear reward inaction algorithm enables prediction number cores assigned search strategy based previous experiments reducing computing time required solve constraint satisfaction optimization problems underlying principle portfolio approach run sequential search strategies using computing cores portfolio core uses strategy order perform search different strategies used cores first strategy finds solution stops strategies problem portfolio approach number search strategies small compared current number computing cores used parallel machines however using internal parallelization search strategy possible run parallel search using computing cores portfolio portfolio performs suboptimally solving different problems many computing resources wasted improve portfolio model adaptive portfolio proposed tries privilege strategy likely find solution first order give computing cores strategies however main problem adaptive portfolio loses learned information end search designed solve one problem furthermore many computational resources wasted portfolio solvers non adaptive adaptive portfolio employed industrial projects pajero project always solves different instances problem minimize amount wasted resources learn efficient search strategies propose new learning portfolio solver uses learning algorithm configures automatically number cores search performance obtained using different portfolio solvers compared illustrated solving problems using example google tools solver copyright john wiley sons ltd
survivors critical illness often experience long lasting impairments mental cognitive physical functioning acute stress reactions delusional memories appear play important role psychological morbidity following critical illness interventions exist address symptoms review elucidates acute psychological stressors experienced critically ill effects psychological stress state mind disease discussed using examples non intensive care unit icu literature including review placebo nocebo effects reviewing effect mind psychological physiological outcomes focus role memories including malleable nature consequences false memories memory may play role genesis subsequent psychological trauma traumatic memories may begin forming even patient arrives icu state unconsciousness icu hence practical interventions redirecting patients thoughts positive suggestion techniques actively involving patients treatment process early possible worthy investigation
paper novel robust vibration control scheme namely one degree freedom fuzzy active force control dof fafc applied nonlinear electromagnetic actuated flexible plate system first flexible plate clamped free clamped free cfcf boundary conditions modeled simulated validity simulation platform evaluated experiment nonlinear electromagnetic actuator developed experimentally modeled parametric system identification scheme next obtained nonlinear model actuator applied simulation platform performance proposed control technique suppressing unwanted vibrations investigated via simulation fuzzy controller applied robust dof control scheme tune controller gain using acceleration feedback consequently intelligent self tuning vibration control strategy based inexpensive acceleration sensor proposed paper furthermore demonstrated proposed acceleration based control technique owns benefits conventional velocity feedback controllers finally experimental rig developed investigate effectiveness dof fafc scheme found first second third resonant modes flexible system attenuated respectively effectiveness proposed control scheme affirmed
many psychiatric behavioral disorders manifest childhood attention deficit hyperactivity disorder obsessive compulsive disorder anxiety depression schizophrenia autism spectrum disorder etc opportunity intervening early may attenuate full development disorder lessen long term disability yet pediatric drug approvals cns indications limited pediatric testing generally occurs establishing adult efficacy afterthought rather initial goal developing medication pediatric cns indication pharmaceutical companies decreasing funding neuroscience research divisions overall prospects moving promising investigational drugs forward pediatrics decline goal review highlight important challenges around pediatric drug development psychiatric disorders specifically clinical development present opportunities filling gaps using new strategies risking investigational drugs new clinical trial designs models first present current trends pediatric drug efficacy testing academic research industry trials discuss regulatory landscape pediatric drug testing including policies intended support encourage testing obstacles remain presented followed new designs funding opportunities considerations testing investigational drugs safely published elsevier ltd
paper presents power management system household photovoltaic battery hybrid power system within demand side management time use electricity tariff system easy implement employing cheap electrical switches shelf chargers inverters control system models combining power dispatching level home appliance scheduling level proposed minimize residents energy cost energy consumption grid practical constraints strictly satisfied addition resident comfort inconvenience level considered control system models trade among operating cost energy consumption inconvenience considered multi objective optimization problem formulated optimal control strategies derived solving mixed integer nonlinear programming problem simulation results show energy cost energy consumption grid largely reduced proposed strategies results important customers dispel major uncertainty determining whether newly install update photovoltaic battery hybrid power systems elsevier ltd rights reserved
schizophrenia highly heritable whereas effect genetic variant weak since clinical heterogeneity complexity schizophrenia high considerable effort made relate genetic variants underlying neurobiological aspects schizophrenia endophenotypes given polygenic nature schizophrenia goal form measure additive genetic risk explore relationship cortical morphology utilizing data recent genome wide association study included nearly cases schizophrenia computed polygenic risk score pgrs subject independent healthy general populations investigated effect polygenic risk schizophrenia cortical gyrification calculated structural imaging data discovery dataset replication dataset found consistent effect polygenic risk schizophrenia cortical gyrification inferior parietal lobules independent general population samples higher pgrs significantly associated lower local gyrification index bilateral inferior parietal lobles case control differences reported previous studies schizophrenia findings strongly support effectiveness pgrss endophenotypes establishing genetic architecture psychiatry findings may provide implications regarding individual differences genetic risk schizophrenia cortical morphology brain development
background aims development direct acting antiviral agents daas major step forward treatment hepatitis hcv aims study evaluate efficacy tolerability daas kidney transplant recipients methods hepa spanish registry patients treated daas clinical virological analytical data prospectively included report data recipients received daas results commonly used daas combinations sofosbuvir ledipasvir sofosbuvir daclatasvir ribavirin used patients sustained viral response weeks svr rate grade anemia appeared patients receiving ribavirin without three episodes acute humoral graft rejection patient discontinued therapy due adverse events importantly patients required immunosuppression dose adjustment overall statistically significant differences mean level serum creatinine egfr proteinuria treatment nonetheless seventeen patients experienced renal dysfunction increase serum creatinine antiviral therapy cirrhotic comparison cirrhotic patients develop significant renal dysfunction conclusions antiviral therapy daas highly efficacious safe recipients nevertheless non negligible number patients cirrhotic developed mild allograft dys function significant proportion patients required immunosuppression dose adjustment warranting close follow therapy lay summary infection hepatitis virus often found kidney transplant patients presence increases mortality graft failure investigated efficacy safety new direct acting hepatitis antivirals population previous information scarce data shows occurs non transplant setting new anti hcv antivirals highly efficacious kidney transplant patients overall therapy also quite safe although worsening renal function observed patients warranting close follow observation graft function antiviral therapy european association study liver published elsevier rights reserved
application fibers extensive pollution caused abandoned fibers getting serious aroused wide attention necessary find way solve problem paper para aramid fiber recycled modified phosphoric acid applied environmental friendly flame retardant thermoplastic polyurethane elastomer tpu flame retardant properties tpu tested using cone calorimeter test cct thermogravimetric fourier transform infrared spectroscopy cct test showed better flame retardant effect tpu pure remarkably phrr value sample content decreased improved char forming progress residual mass much pure tpu test showed could improve thermal stability tpu high temperature test revealed reduced release beginning based results make great influence study reuse fibers environmental friendly flame retardant polymer elsevier rights reserved
exploratory research examines whether attracted professional level occupations built environment industry innately physical risk takers hence potentially thereby likely countenance contribute physically risky workplace climates using individual level data occupational attractiveness built environment industry subsectors construction management architecture found positively significantly predicted physical risk taking propensity comparator risk taking propensity gambling conversely occupational attractiveness comparator profession financial services found significantly predicted gambling risk taking propensity physical risk taking propensity although exploratory finding two key professions built environment industry discretely found attractive physical risk takers suggests constituent occupations within industry industry whole might perhaps engender self reinforcing suboptimal workplace safety climate accordingly constituent subsectors industry may need separately collectively consider phenomenon physical risk taking propensity amongst professionals attracts order effectively set manage site work place safety climate professionals ultimately responsible creating delivering sector fraught physical risks site workers
motor evoked potentials meps produced single pulse transcranial magnetic stimulation tms motor cortex objective measure cortical excitability previously mep thresholds found normal increased even reduced patients migraine present study determined whether level cortical excitability changes time interval last migraine attack thereby accounting inconsistencies previous reports twenty six patients untreated migraine without aura underwent mep study attacks data compared mep data collected group healthy volunteers hvs experiment tms figure eight coil positioned left motor area identifying resting motor threshold rmt delivered single tms pulses rate intensity rmt averaged resulting mep amplitudes mean rmts mep amplitudes significantly different groups patients rmts negatively correlated number days elapsed since last migraine attack rho results suggest threshold evoking meps influenced proximity attack specifically threshold lower long time interval passed attack higher within range normative values measured close attack dynamic rmt variations resemble reported previously visual somatosensory evoked potentials may represent time dependent plastic changes brain excitability relation migraine cycle
background hormone based birth control often causes various side effects recent study revealed temporary infertility without changing hormone levels attained inhibiting katanin atpase containing subunit like protein katnal critical sperm maturation testes objective study aimed attaining energetically stable three dimensional structure katnal protein using comparative modeling followed screening ligand library known natural spermicidal compounds binding affinity katnal turn may inhibit development mature sperm seminiferous epithelium method series computational techniques used building structure katnal optimized molecular dynamics simulation revealing atp binding mode katnal docking study carried using optimized model obtained simulation docking study also employed test binding efficiency ligand library results molecular docking study confirmed atp binding katnal various hydrophobic hydrogen bond interactions binding efficiency ligand library suggested calotropin cardenolide calotropis procera showed highest binding efficiency target protein without toxicity simulation docked complex validated results docking study conclusion study revealed atp binding mode katnal identified calotropin potential lead molecule showing high binding efficiency good bioavailability mutagenicity vitro vivo bioassay calotropin could facilitate development novel non hormonal male specific contraceptive near future
present study aimed investigate alterations toll like receptor tlr interferon regulatory factor irf interferon gamma inducible protein evaluate whether factors may associated sustained virological response svr among patients hepatitis virus genotype hcv treated peginterferon plus ribavirin peg ifn rbv total chinese patients infected hcv enrolled present study patients obtained svr expression levels declined significantly peg ifn rbv therapy week time points compared baseline respectively addition observed irf mrna expression number tlr peripheral blood mononuclear cells exhibited similar correlations concentration respectively svr group patients however correlations observed present non svr group patients conclusion results present study suggest marked alterations tlr irf expression may serve indicators development svr patients hcv treated peg ifn rbv
plate model describing statics dynamics suspension bridge suggested partially hinged plate subject nonlinear restoring hangers considered whole theory linear problems nonlinear stationary equations ending full hyperbolic evolution equation studied paper aims starting point refined models
background primary mediastinal large cell lymphoma pmbl shares pathological features diffuse large cell lymphoma dlbcl molecular features classical hodgkin lymphoma chl mir similar oncogenic cluster located chromosome region amplified dlbcl methods compared expression member mir similar oncogenic cluster samples pmbl patients versus dlbcl chl patients studied target genes linked deregulated mirna pmbl results found higher level mir pmbl dlbcl chl combination silico prediction transcriptomic analyses enabled identify foxp main mir target gene pmbl result far established confirmed utr rna protein expressions transduced cell lines vivo studies using transduced cell lines mice enabled demonstrate tumor suppressor effect mir oncogenic effect foxp higher expression mir regulation foxp mrna protein expression also found human samples pmbl mir expression low foxp high dlbcl conclusions concluded post transcriptional regulation mir foxp targeting pmbl clinico pathological relevance better characterisation pmbl
anterolateral group bed nucleus stria terminalis bnstalg critical modulator variety rodent primate behaviors spanning anxiety behavior drug addiction three distinct neuronal cell types previously defined rat bnstalg based differences voltage response hyperpolarizing depolarizing current injection differences genetic expression profile three cell types suggest electrophysiological cell type may indicator functional differences circuit rat bnstalg although behavioral role bnst conserved across species unknown electrophysiological cell types exist bnstalg mouse nonhuman primate used whole cell patch clamp electrophysiology neuronal reconstructions biocytin filled neurons compare contrast electrophysiological morphological properties neurons bnstalg mouse rat rhesus macaque provide evidence bnstalg three species contains neurons match three defined cell types found rat however intriguing differences relative frequency cell types well electrophysiological morphological properties bnstalg neurons across species study suggests overall landscape bnstalg primate mouse may similar rat aspects perhaps significantly different others
background low functional ovarian reserve ages associated low testosterone levels causes however unknown therefore investigate whether androgens low associated non specific immune system activation methods infertile women low normal controls assessed broadly based immune profile previous studies proven effective differentiating infertile patients without immune system activation patients either immune positive greater equal one positive tested parameter immune negative positive test suffered prematurely diminished poa opoi age controls age normal age specific prevalence immune positive negative assessed patient groups results women immune abnormalities overall demonstrated higher total free levels without three clinical two immunologic defined patient groups demonstrated significant statistical interaction mean mean women positive immune findings significantly higher control poa opoi physiologic dor patients differences differences three groups seen women without immune abnormalities conclusions study used definition immune positivity favors sensitivity specificity resulting significant numbers false positives likely false negatives study allows suggesting possibility immune system derived androgen production factor apf maintains normal androgen levels deficient women low immune system inactivity existence apf would suggest presence still unknown functional adrenal autoimmune system
purpose reviewto provide update epidemiology pathophysiology clinical presentation management colonic ischemia recent findingsformerly regarded rare cause lower gastrointestinal hemorrhage colonic ischemia recognized common manifestation intestinal vascular compromise contrast ischemic events small intestine wherein thrombotic embolic events predominate colonic ischemia typically results global reduction blood flow colon occlusive lesion evident several risk factors colonic ischemia identified together appropriate clinical presentation patient demographics create context clinician high level suspicion presence imaging computerized tomography particular may highly supportive diagnosis appropriate confirmed colonoscopy colonic biopsy patients management supportive noninterventional prognosis recurrence survival excellent summarycolonic ischemia common cause lower abdominal pain hemorrhage among elderly typically occurring aftermath event led hypoperfusion colon affected individuals ischemia reversible clinical course benign
pitch control comprises significant proportion current wind turbine load control approaches collective pitching used restricting overall power generation high winds whereas individual pitching added advantage mitigating cyclic loads detrimental fatigue damage turbines currently many studies conventional pitching control account long term variations wind speeds associated high loads smaller number studies short term pitch action present study focuses use rapid pitch control handling short term variations wind conditions load fluctuations within one cycle rotation special attention prognosis aeroelastic response rotor use numerical model capable handling complexities multi physics dynamics wind turbine rotor based nonlinear adaptive ode algorithm provides natural way integrate various multi physics aspects wind turbine dynamics including control system coupled response aerodynamics structural deformations rotor results presented case study nrel reference wind turbine significance wind turbine rotors general discussed elsevier ltd rights reserved
migration health systems cloud computing brings huge benefits security risks searchable encryption cryptography encryption scheme protect confidentiality data utilize encrypted data time scheme proposed cash crypto follow work ccs practical scheme support boolean queries present scheme data user generate search tokens counter number one one interact server repeatedly meets correct one goes plenty tokens illustrate search result paper make improvement scheme allow server send back information help user generate exact search token search phase scheme two round interaction server user search token vertical bar vertical bar elements keywords number query expression vertical bar vertical bar minimum documents number contains one keyword query expression computation cost server vertical bar vertical bar modular exponentiation operation
compostable dinnerware used tested jeux canada games university regina prior following games several research activities undertaken examine structural integrity user friendliness consumer opinions general compostability dinnerware various conditions results indicate consumers highly motivated purchase use environmentally friendly options structural integrity sufficient applications overall dinnerware performed advertised manufacturer composted within week timeframe
impact anti tumor necrosis factor alpha tnf alpha treatment crohn disease surgical outcomes still controversial aim study assess feasibility laparoscopic surgery patients treated preoperatively anti tnf alpha agents investigated retrospectively clinical features surgical outcomes consecutive patients underwent laparoscopic surgery receiving scheduled anti tnf alpha treatment preoperatively compared surgical outcomes early surgery group comprised patients underwent surgery less years initiation anti tnf alpha treatment late surgery group comprised patients underwent surgery years initiation anti tnf alpha treatment mean operating time blood loss min respectively rates conversion open surgery postoperative complications respectively operating time blood loss correlated interval initiation anti tnf alpha agent treatment time surgery proportion patients acquired resistance anti tnf alpha agents rate conversion open surgery higher operating times longer late surgery group early surgery group laparoscopic surgery performed safely patients treated preoperatively anti tnf alpha agents although operating times may longer estimated blood loss ebl greater prolonged anti tnf alpha treatment
growth mechanism amorphous carbon film liquid deposition process still unclear study influence applied voltages surface morphology microstructure amorphous carbon films investigated well bonding probability film substrate interface new mechanism film growth proposed electrochemistry non equilibrium thermodynamics viewpoints results showed growth amorphous carbon film involved island groove morphology graphitic carbons present within film applied voltage increased coupling model growth mechanism including ionization absorption dehydrogenation process chemical volume polymerization highlighted copyright john wiley sons ltd
designing envelope configurations office building low construction cost energy consumption discrete optimization problem configuration currently determined merely architects experiences resulting inefficient expense building energy performance simulation time intensive involves complex processes based efficient regression equation substitute complex energy simulators study developed office building envelope energy performance configuration model obem provide envelope configurations including construction material sunshade type sunshade length window number window length width architects reference also tabu search effective solving discrete optimization problems integrated obem optimal obem decision support system opobem opobem applied real office building construction optimizing envelope configuration minimum construction budget energy conservation regulations green buildings result shows optimized installation sunshade type efficiently reduces solar heat gain according high variation sunshade coefficient thus achieves goal energy conservation reduces envelope costs compared architects manual estimation optimized envelope design realizes nearly budget savings thus demonstrating feasibility proposed opobem elsevier ltd rights reserved
study explored impact staff group role length organizational tenure relationship awareness stress interventions termed intervention awareness work related attitudinal outcomes university employees two wave longitudinal study sample employees universities completed psychosocial work factors health questionnaire hierarchical regression analyses examined contribution staff role different lengths organizational tenure employees reports job satisfaction affective organizational commitment trust senior management perceived procedural justice employees length tenure affected relation work attitudes also differences academic non academic staff groups non academic employees predicted job satisfaction affective organizational commitment trust senior management perceived procedural justice however academics predicted job satisfaction trust identifies need increase visibility organizational interventions across tenure groups predicted perceived procedural justice employees five less years tenure job satisfaction employees years tenure trust senior management employees years tenure affective organizational commitment employees tenure length years employees working university intermediate period positive perceptions organization terms job satisfaction trust senior management affective organizational commitment whereas employees years tenure least positive perceptions results suggest employees middle careers report positive perceptions university findings highlight need attend contextual issues organizational stress wellbeing interventions suggest management may need implement new strategies promote existing stress management reduction strategies academics employees either new university working organization longer periods time ensure aware organizational strategies promote employee wellbeing morale within work environments
paper presents results load tests conducted laboratory embedded model strip footing resting reinforced dense sand bed reinforcement used woven geotextile wraparound ends well without wraparound ends investigating benefits providing wraparounds number reinforcement layers varied ratio embedment depth footing width called embedment depth ratio varied effect utilizing wraparound ends reinforcement load bearing capacity reinforced sand bed special interest study experimental results arising study compared numerical findings based finite element analysis fea carried using plaxis software study shows significant improvement load bearing capacity stiffness sand bed increasing number reinforcement layers well provision wraparound ends reinforcement numerical results follow experimental results closely lower settlement values graphical presentations results experimentation used preliminary design guidelines field applications conditions similar considered present study however results presented paper may require modifications suitably account difference scale laboratory field conditions using practical applications
effects target emissivity apparent thermal contrast well detection range capabilities thermal imagers long wave infrared middle wave infrared bands evaluated apparent thermal contrast seen thermal imager standoff distance considering emission target background first computed bands terms target emissivity secondly apparent thermal contrast considering background radiation reflected target also computed graphical user interface simulation matlab prepared estimation total apparent thermal contrast taking account emission reflection total apparent thermal contrast finally used night vision thermal image processing model predicting detection range performance thermal imagers results analysis show effect target emissivity thermal contrast estimates pronounced lwir lower thermodynamic temperature difference target background lower values target emissivity leads negative thermal contrast turn leads higher detection ranges
petroleum cyber physical system cps interwell connectivity estimation critical improving petroleum production accurately estimated connectivity topology facilitates reduction production cost improvement waterflood management paper presents first study focused computer aided design petroleum cps new cps framework developed estimate petroleum well connectivities framework explores innovative water oil index integrated advanced cross entropy optimization applied real industrial petroleum field massive petroleum cps data experimental results demonstrate automated estimations well match expensive tracerbased true observations demonstrates framework highly promising
studies examining hemispheric asymmetries false memory shown right hemisphere susceptible false memories compared left hemisphere theories suggest hemispheric asymmetries true false memory may due differences representational coding use top mechanisms hemisphere current study deese roediger mcdermott false memory paradigmwas used conjunction divided visual field presentation examine role top mechanisms hemispheric asymmetries true false memory experiment participants studied lists related words completing secondary cognitive load tasks experiment secondary tasks administered memory retrieval instead memory encoding results revealed cognitive loads imposed study phase influenced veridical memory cognitive loads imposed retrieval influence veridical memory either hemisphere surprisingly false memory rates influenced cognitive loads higher data provide evidence least veridical memory top control mechanisms used readily encoding information memory compared
implanted devices brain required vivo experiments freely moving animals become key element future neuronal interfaces prosthetic limbs neural control maintain optimal signal quality cope micro motions implant plastic reorganization brain concept electronic depth control developed combines high spatial resolution neuron sized electrodes processing power cmos electronics challenges cmos probes active assistance arise fact recording site equipped gain stage consuming little area work gives overview recent high density neuronal probes presents solutions area efficient implementations analog signal processing features like line bandwidth variation autonomous start common mode referencing
background research supports beneficial role prosocial behaviors children adjustment successful youth development empirical studies point reciprocal relations negative parenting children maladjustment reciprocal relations positive parenting children prosocial behavior understudied study reciprocal relations two different dimensions positive parenting quality mother child relationship use balanced positive discipline children prosocial behavior examined colombia italy jordan kenya philippines sweden thailand united states methods mother child dyads provided data years two waves mage child wave years female results model reciprocal relations parenting dimensions among parenting children prosocial behavior emerged particular children higher levels prosocial behavior age elicited higher levels mother child relationship quality following year conclusions findings yielded similar relations across countries evidencing prosocial late childhood contributes degree enhancement nurturing involved mother child relationship countries vary widely sociodemographic profiles psychological characteristics policy intervention implications study discussed
previous research suggests racial identity racial cues extent event blatantly ambiguously race related individually shape african american individuals experiences racial discrimination however scant attention paid interactive transactional influences factors present study examined direct effects racial cues interactive effects racial cues racial identityspecifically extent aas believe others view aas negativelyon aas interpretations affective responses lab based findings revealed direct effect racial cues participants perceptions event race relevant participants affect moreover racial identity moderated associations racial cues participants perceptions affective responses findings suggest aas experiences homogeneous interplay transaction racial cues racial identity vital experiences
symbolic computation bell polynomial scheme bilinear method applied two dimensional korteweg vries kdv model firstly proposed lax pair generating technique bell polynomial expression one auxiliary independent variable derived transformed bilinear form according coupled two field conditions primary replica fields bell polynomial typed backlund transformations bts constructed converted bilinear ones finally soliton solutions two dimensional kdv model obtained via solving bilinear representation respectively compared associated integrable properties bilinear representation especially auxiliary independent variable involved bell polynomial typed ones constructed paper soliton solutions especially multi soliton ones may useful study two dimensional kdv kdv typed models elsevier inc rights reserved
achieve high performance control modern converters using direct digital design techniques accurate discrete model converter necessary paper new parametric system identification method based kalman filter approach introduced estimate discrete model synchronous buck converter improve tracking performance proposed adaptive tuning technique proposed unlike many published schemes approach offers unique advantage updating parameter vector coefficients different rates proposed estimation technique experimentally verified using texas instruments tmsf micro controller platform synchronous step converter results demonstrate robust reliable real time estimator proposed method accurately identify discrete coefficients converter paper also validates performance identification algorithm time varying parameters abrupt load change proposed method demonstrates robust estimation without excitation signal makes well suited real time power electronic control applications furthermore estimator convergence time significantly shorter compared many schemes classical exponentially weighted recursive least squares method
cortical spreading depression csd associated migraine stroke traumatic brain injury mechanisms remain poorly understood one major features csd hour long silencing neuronal activity though silencing clear ramifications csd associated disease fully explained used vivo whole cell recordings examine effects csd layer pyramidal neurons mouse somatosensory cortex used vitro recordings examine mechanism found csd caused reduction spontaneous synaptic activity action potential firing lasted hour pre postsynaptic mechanisms contributed silencing reductions frequency postsynaptic potentials due reduction presynaptic transmitter release probability well reduced activity decreases postsynaptic potential amplitudewere due inhibitory shift ratio excitatory inhibitory postsynaptic currents inhibitory shift turn contributed reduced frequency aps thus distinct complementary mechanisms generate long neuronal silence follows csd cellular changes could contribute wider network dysfunction csd associated disease pre postsynaptic mechanisms offer separate targets therapy
sensitive triggered electrical switch demonstrated using layer structured silver nanowire polyaniline nanocomposite film fabricated via easy vertical spinning method prepared nanocomposite film shows high electrical conductivity areal density good cycling stability particularly layered structure switch achieves high contrast ratio orders higher reported previously high electrical conductivity high switching ratio make layer structured nanocomposite film sensitive switch candidate responsive systems finally smart self adjusting switching system successfully designed using prepared layer structured nanocomposite film
paper presents cost effective control algorithm standalone batteryless photovoltaic systems control driven fuzzy based maximum power point tracker capabilities maintain high energy conversion efficiency different weather load conditions general design considerations presented based linearization dynamic model entire system consists panel cuk converter motor load particular fuzzy mppt controller design considerations combined artificial intelligent technique achieve optimum control design furthermore developed control algorithm voltage regulation capability protect load overvoltage light load conditions fast digital overload protection transient steady state performance entire system modeled nonlinear state space representation proposed control simulated matlab experimentally tested fast variation climatic conditions verification purposes good agreement shown theoretical simulations experimental results
background study evaluated impact obesity overweight achievement minimal disease activity mda patients psoriatic arthritis psa patients rheumatoid arthritis receiving anti rheumatic treatment obesity considered low grade chronic systemic inflammatory disease studies suggested obese patients rheumatic diseases exhibit lower rate low disease activity achievement treatment anti rheumatic drugs methods systematic search performed major electronic databases pubmed web science scopus embase identify studies reporting mda achievement obese overweight patients psa normal weight psa control subjects results expressed odds ratios ors pertinent confidence intervals cis results included studies psa comprising total patients psa analysis mda achievement rate significantly lower obese patients normal weight subjects similarly overweight patients showed significantly lower prevalence mda achievement normal weight subjects interestingly effect obesity mda confirmed separately analyzed data patients patients psa contrast evaluated effect overweight results confirmed psa meta regression analysis showed follow duration age male sex treatment duration covariates significantly affecting effect obesity overweight mda achievement conclusions results meta analysis suggest obesity overweight reduce chances achieve mda patients rheumatic diseases receiving treatment traditional biologic disease modifying antirheumatic drugs
background assessing results health care delivery system reforms targeting persons disability quality metrics must reflect experiences perspectives population objective persons disability researchers develop collaboratively survey addresses critical quality questions new massachusetts health care program persons disability dually eligible medicare medicaid methods persons significant physical disability serious mental health diagnoses participated fully research activities including directing study moderating focus groups performing qualitative analyses specifying survey topics cognitive interviewing refining survey language several sources informed survey development including key informant interviews focus groups cognitive testing results interviewed key informants key stakeholder groups including disability advocates health care providers governmental agencies conducted total english spanish language focus groups involving participants physical disability mental health diagnoses although details differed focus group findings similar across two disability groups analyses collaborators disability identified questions persons physical disability persons mental health diagnoses cognitive testing final survey includes questions topics ranging independent living principles health care delivery system concerns conclusions persons disabilities quality survey pdq captures specific quality concerns massachusetts residents physical mental health disability integrated health plan pdq requires testing elsewhere determine value quality assessment generally populations disability elsevier inc rights reserved
background indian sundarbans marked inhospitable terrain frequent climatic shocks jointly hinder access health care community members women particular means communicate concerns local decision makers photovoice one way communities raise local health challenges decision makers study unlocks mothers voices determinants children health inform local level decision making child health issues indian sundarbans methods photovoice action research conducted three blocks sundarbans region west bengal india project involved eight groups eight ten mothers least one child years age across four villages mothers received training photo documentation ethical concerns taking two rounds photographs within months interspersed fortnightly group meetings facilitated researchers photographs key messages communicated local decision makers block village level interface sessions mothers researchers results mothers photos focused specific determinants health water sanitation health status malnutrition non communicable diseases service accessibility climate conditions social issues early marriage recurrent pregnancy issues captured photos discussed group meetings including domestic violence non availability medical practitioners found differences mother educational status livelihood caste identity extent nature photographs taken result mother interface community decision makers included showcasing selection photos efforts improve road infrastructure human resource availability primary health centres local government realized conclusion photovoice potential express voices vulnerable communities regarding health needs help dialogue local decision makers inform community health policy planning needs done understand social differences among photovoice participants influences engage methodology
previous research shown rating words relevance future scenario enhances memory words current study investigated effect future thinking false memory using deese roediger mcdermott drm procedure experiment participants rated words drm lists relevance past future event without planning terms pleasantness surprise recall test levels correct recall vary rating tasks future rating conditions led significantly higher levels false recall past pleasantness conditions experiment found future rating led higher levels false recognition past pleasantness ratings affect correct recognition effect false recognition however eliminated drm items presented random order participants experiment presented drm lists lists unrelated words future rating increased levels false recognition drm lures affect correct recognition drm unrelated lists findings discussed terms view false memories associated adaptive memory functions
aims objective study evaluate efficacy safety combined treatment agonist rock inhibitor rat model detrusor overactivity induced retinyl acetate instillation methods rock inhibitor gsk agonist brl administered single doses cystometry carried along measurement cardiovascular parameters diuresis results combined use gsk brl doses ineffective monotherapies ameliorated increase found voided volume voiding efficiency volume threshold intercontraction interval bladder compliance volume threshold elicit nonvoiding contractions accompanied decrease basal pressure threshold pressure detrusor overactivity index nonvoiding contractions amplitude frequency combination therapy question proved effect micturition voiding pressure post void residual bladder contraction duration relaxation time observation female rats received gsk brl show significant changes urine production brl increased heart rate blood pressure proportionately applied dose assessment combined treatment gsk brl revealed significant drop cardiovascular parameters compared rats received brl discussion combined use agonists rock inhibitors may improve overactive bladder treatment efficacy minimize side effects conclusion polytherapy appears improve urine storage impairment voiding function neurourol urodynam wiley periodicals inc
selection appropriate implant material stainless steel titanium still decision surgeon affiliated institution additionally remarkable international differences found different markets really explained systematic literature search performed verify whether clinical evidence preference one material systematic literature search performed utilizing internet databases pubmed cochrane web science comparative studies included reported adult patients osteosynthesis extremities trauma using either stainless steel titanium implants information extracted infection rates incidence clinically relevant allergies problems implant removal complications total publications identified eligible referenced articles added summary insufficient clinical evidence use titanium steel implants positive negative effect fracture healing shows different rates allergies different rates infections mechanical failure supporting evidence could identified difficulties removal titanium implants reported surgeons systematic literature search provide clinical evidence material related differences titanium stainless steel implants fracture fixation based current clinical evidence titanium steel implants considered equal value reported difficulties implant removal reflected published literature
laboratory triaxial compression tests conducted investigate stress strain volumetric responses geotextile reinforced sand mobilization distribution reinforcement strain loads soil geotextile interface shear stress within reinforced soil geotextile reinforced sand specimens tested varying confining pressures number geotextile reinforcement layers digital image processing technique applied determine residual tensile strain reinforcements tests estimate reinforcement tensile loads experimental results indicate geotextile reinforcement enhanced peak shear strength axial strain failure reduced loss post peak shear strength reinforced specimen higher shear strength compared unreinforced soil deforming axial strain indicates geotextile requires sufficient deformation mobilize tensile force improve shear strength reinforced soil reinforcement layer mobilized tensile strain peaked center reinforcement decreased along radial direction interface shear stress zero center peaked distance reinforcement radius center mobilized tensile strain reinforcement increases confining pressure number reinforcement layers increase work also demonstrates strength difference reinforced unreinforced soil strongly correlated sum maximum mobilized tensile forces reinforcement layers indicating mobilized tensile force reinforcements directly improved shear strength reinforced soil last number analytical models predict peak shear strength reinforced soil verified experimentally verification demonstrates mobilized tensile force rather ultimate tensile strength used analytical models
atopic dermatitis chronic pruritic inflammatory disease commonly presents pediatric population although definitions diagnosis largely agreed upon allergists dermatologists similar divergent approaches management review facilitated integration american academy allergy asthma immunology american college allergy asthma immunology joint task force practice parameter american academy dermatology guidelines highlight basic principles management discuss therapies management distinct perspectives allergist dermatologist
background level community hospital labor delivery recovery postpartum ldrp unit delivering babies per year operating without dedicated neonatal resuscitation stabilization support purpose lack funding space provide onsite level neonatal intensive care unit nicu position created provide neonatal nurse practitioner nnp coverage support ldrp unit method article describes innovative solution nnp team rotate regional neonatal intensive care program busy community ldrp unit presence nnp supported development integration advanced practice nursing role interdisciplinary team members ldrp emergency department results nnp able provide expertise leadership mentorship neonatal resuscitation stabilization well education consultation neonatal care addition services provided nnp infant requiring acute care nnp provided transitional support infants remained mothers ldrp unit furthermore time required neonatal transport team stabilize babies transport nicu decreased nnp presence implications practice divergence practice traditional nnp clinical role nicu setting consultant nursing leader proven valued role community hospital implications research solid economic analysis cost effectiveness nnp role community hospital warranted
one easiest ways induce illusory memories laboratory use deese roediger mcdermott drm word list paradigm researchers used paradigm study people memories stimuli actually presented also study phenomenological qualities illusions four experiments current investigation explored phenomenological quality illusory memories received almost attention specifically temporality serial position task incorporated drm paradigm examine temporal attributes participants true false memories effects list strength presentation order types warnings examined results showed consistent serial position responses true false memories however responses illusory memories affected manipulations study current findings thus lend support encoding based explanations false recollections
paper gives comprehensive introduction logical control systems lcss including history logical background expression fundamental mathematical tool analyzing method particularly emphasized major achievements logical dynamic systems ldss control theory last years consisting topological structure ldss controllability observability stability stabilization disturbance decoupling optimal control identification logical control systems iii extension results boolean systems valued mix valued logical control systems results form foundation logical control system theory lcst addition concepts notations fundamental method tool formally normalized current developments lcst applications potential applications discussed detail open problems possible research directions introduced
risk epidemics emerging emerging diseases rising contained prevention early warning prompt management readiness exercises critical improving readiness testing means methods master plans procedures training civil protection personnel however despite progress information technology feedback recent exercises suggests communication bottleneck health early warning response systems paper reports experience deployment safe component based system health early warning two day earthquake readiness exercise island crete safe employs satellite radio wireless networks geographic information systems integration technology data mining promptly identify respond disease outbreak acute phase disaster exercise mobile satellite enabled coordination van safe provided access health emergency information system via personal digital assistants pdas also conveyed sights sounds disaster decision makers post disaster management safe interoperability local information systems intended health monitoring earthquake refugee camp well prompt identification management outbreak collaboration expert centers exercise identified significant strengths also weaknesses addressed health early warning public health time participants observers recognized safe offers valuable tools epidemic intelligence paving way towards advanced preparedness response lifting communication barriers promoting collaboration reducing isolation affected areas
aim study determine characteristic features contribute inappropriate eating attitudes people suffering anorexia nervosa based analysis recent data factors influencing attitudes genetic neurobiological biochemical affective motivational cognitive behavioral background another important issue addressed paper description mechanism leading continuous dietary restrictions altered activity neurotransmitters modulating patients moods consumption food disturbed responsiveness enterohormones enhance affective motivational cognitive aspects turn impede improvement eating behaviors understanding mechanisms behind factors affecting maintenance inappropriate eating attitudes may contribute greater effectiveness treatment anorexia nervosa
miniaturization electronic devices steadily reduced size cost power density battery increased lot batteries prime agent penetrate expand ubiquitous life intrinsically low energy densities short lifetimes impose fundamental limitation due reasons small linear reciprocating engine electric generator designed portable power pack paper engine used solely produce electrical power portable power pack necessary convert reciprocating linear motion piston rotary motion instead linear electrical generator may coupled directly piston conversion mechanical energy electrical energy design many advantages mechanical simplicity low friction make possible small engine high efficiency
paper introduced self tuning fuzzy pid controller based particle swarm optimization aims gain precise control position pneumatic proportional valve barrel particle swarm works optimize membership function fuzzy rule pid parameter fuzzy control study fruits also include online optimization self tuning fuzzy pid controller parameters comparing conventional control methodology self tuning fuzzy pid controller pso optimization proven show better precision dynamic performance index rapid tracking performance robustness end step response used compare analyze results pso algorithm optimization providing pragmatic method better comprehensive performance pid parameter optimization
accurately estimated state great importance maintaining stable running condition power systems maintain accuracy estimated state bad data detection bdd utilized power systems get rid erroneous measurements due meter failures outside attacks however false data injection fdi attacks recently revealed circumvent bdd insert bias value estimated state continuous works constructing protecting power systems attacks done recent years survey comprehensively overviews three major aspects constructing fdi attacks impacts fdi attacks electricity market defending fdi attacks specifically first explore problem constructing fdi attacks show associated impacts electricity market operations adversary point view perspective system operator present countermeasures fdi attacks also outline future research directions potential challenges based overview context fdi attacks impacts defense
objectives aim study evaluate ability novel web mobile application identify woman ovulation day fertile window order use method natural birth control methods retrospective study performed cycles women aged years women entered basal body temperatures ovulation test results date menstruation application results mean delay first positive ovulation test temperature based estimation ovulation day days length luteal phase varied average days per user non fertile days falsely attributed found within fertile window conclusions method effective identifying user ovulation day fertile window therefore used natural method birth control
parkinson disease prevalence apraxia increases disease severity implying patients early stages may already subclinical deficits aim exploratory fmri study investigate subclinical aberrations praxis network already present patients early previous functional imaging literature data basal motor functions exists thirteen patients mild parkinsonian symptoms without clinically diagnosed apraxia healthy controls entered study fmri participants performed pantomime task imitated use visually presented objects patients measured dopaminergic therapy evaluate potential medication effect praxis abilities related brain functions although none patients apraxic according renzi ideomotor scores range patients showed significantly lower praxis scores controls patients exhibited significant hyperactivation left fronto parietal core areas praxis network frontal activations clearly dominant patients correlated lower individual praxis scores conclude early patients already show characteristic signs praxis network dysfunctions rely specific hyperactivations avoid clinically evident apraxic symptoms subclinical apraxic deficits shown correlate activation shift left parietal left frontal areas implying prospective individual imaging marker incipient apraxia
purpose present study analyse association sport personal factors incidence injury frequency severity within individual sports swimming tennis athletics collective sports basketball handball football study deemed necessary explore different types sports using samples genders field competition sample composed athletes non injured males non injured females non injured belonging different sports clubs comunidad valenciana spain male athletes average age years standard deviation female athletes average years cross sectional corelational design strategy selective collection data means survey designs used order evaluate injuries auto report registry elaborated results indicated greater number total injuries higher injury rate associated athletes younger age experienced athletes collective athletes gender found important factor discussed relations variables conclusions study indicated
endoscopy remains main technique diagnosis treatment crohn disease nevertheless recent development innovative non invasive imaging techniques led new tool exploration small bowel patients paper reviews available data ultrasound imaging used evaluation highlighting role small intestine contrast enhanced ultrasonography use oral intravenous contrast agents
paper presents novel application magnetostrictive delay lines give possibility real time monitoring strain ceramic components magnetostrictive delay line based highly magnetostrictive amorphous alloy ribbon mounted outside ceramic component new solution increasing sensor sensitivity developed specially sensor hybrid digital analog signal processing unit covers sample hold integrated circuit achived sensitivity repeatability sensor confirms solution suitable ceramic machine tool monitoring
integration existing research newly conducted psychophysiological interaction ppi connectivity analyses suggest new framework understanding contribution midline regions social cognition recent meta analyses suggest midline regions exclusively associated self processing whereas medial prefrontal cortex mpfc broadly modulated self processing subdivisions within mpfc differentially modulated evaluation close others ventral mpfc evaluation social targets dorsal mpfc role dmpfc social cognition may also less uniquely social previously thought may better characterized region indexes certainty evaluation rather previously considered social mechanisms correction self projection vmpfc region often described important mediator socioemotional significance may instead perform cognitive role reflecting type information brought bear evaluations people know well furthermore new framework moves beyond mpfc hypothesizes two midline regions ventral anterior cingulate cortex vacc medial orbitofrontal cortex mofc aid motivational influences social cognition despite central role motivation psychological models self perception neural models largely ignored topic positive connectivity vacc mofc may mediate bottom sensitivity information based potential helping evaluate others way want connectivity becomes positive striatum less positive middle frontal gyrus mofc mediates top motivational influences adjusting standards bring bear evaluations people
analytical solution electrostatic potential enhanced drain current modeled dual metal surround gate junctionless transistor dmsgjlt solving poisson equation using parabolic approximation technique gate engineered dmsgjlt produces increase mobility electrons channel enhancement drain current obtained single metal jlt dimension due gain increases short channel effects leakage current decreases electrostatic potential threshold voltage drain current transconductance drain induced barrier lowering power delay predicted analytical solution excellent agreement simulation results obtained technology computer aided design analytical modeling provides useful insight physics short channel effects inverter circuit implemented dmsgjlt compared single metal device noise margin analysis made inverter circuit employing dual metal single metal devices found gate engineering improves noise margin much extend due voltage loss also improved dmsgjlt
chronic infection hcv leading cause cirrhosis hepatocellular carcinoma liver failure one least understood steps hcv life cycle morphogenesis new viral particles hcv infection alters lipid metabolism generates variety microenvironments cell cytoplasm protect viral proteins rna promoting viral replication assembly lipid droplets lds proposed link viral rna synthesis virion assembly physically associating viral processes hcv assembly envelopment maturation shown take place specialized detergent resistant membranes rich cholesterol sphingolipids supporting synthesis luminal lds containing apoe hcv assembly involves regulated allocation viral host factors viral assembly sites virus budding takes place encapsidation hcv genome viral envelopment interaction apoe envelope proteins supports viral particle acquisition lipids maturation hcv secretion suggested entail ion channel activity viral several components classical trafficking autophagy pathways escrt exosome mediated export viral rna review recent advances virus morphogenesis interplay viral host factors required formation hcv virions
background aim study assess possible relationships adipocyte fatty acid binding protein fabp total body fat tbf abdominal fat body fat distribution aerobic fitness blood pressure cardiac dimensions increase body fat years community sample children methods cross sectional study used community sample boys girls children aged years tbf abdominal fat afm measured dual energy ray absorptiometry dxa tbf also expressed percentage total body mass body fat distribution calculated afm tbf maximal oxygen uptake vopeak assessed indirect calorimetry maximal exercise test scaled body mass systolic diastolic blood pressure sbp dbp pulse pressure measured echocardiography performed left atrial size measured left ventricular mass lvm calculated follow dxa scan available children boys girls frozen serum samples analyzed fabp results partial correlations adjustment sex fabp tbf afm afm tbf vopeak moreover sbp lvm also weakly correlated fabp correlations fabp increase tbf afm years increase percent body fat change fat distribution correlated conclusions findings community based cohort young children show increased body fat abdominal fat abdominal body fat distribution low fitness lvm increased increased sbp associated increased levels fabp increase tbf abdominal fat years also associated increased levels fabp
aim intrinsic parameterization computational optical system applied long distance displacement measurement large scale structures structural monitoring scenario observation distance established digital camera reference targets composed computational optical system range requiring use long focal length lenses order obtain suitable sensitivity three dimensional displacement measurement observed structure reduced magnitude intrinsic parameterization long focal length cameras emergent issue since conventional approaches applied reduced focal length cameras suitable mainly due ill conditioned matrices least squares estimation procedures describe intrinsic parameterization long focal length camera diffractive optical element method present obtained estimates measurement uncertainties discussing contribution system validation calibration field test displacement measurement campaigns long span suspension bridge society photo optical instrumentation engineers spie
increasing evidence experimental non experimental research shown children residing disadvantaged neighborhoods exhibit greater levels internalizing externalizing behaviors beyond individual characteristics family school contexts using ecls nationally representative longitudinal survey school children study examined direct neighborhood effects internalizing externalizing behaviors beginning end elementary school using iptw propensity scores mitigate selection bias ordinary least squares regression examined direct neighborhood effects children years old grade years old grade also examined neighborhood effect modification child child race ethnicity sex family structure family ses direct effect effect modification models indicated living disadvantaged neighborhoods impact either internalizing externalizing behaviors beginning elementary school age end elementary school age found small yet significant direct neighborhood associations effect sizes ranging standard deviations effect modification analysis revealed black relative white strongest moderator relationship neighborhood context internalizing externalizing behaviors grade effect sizes ranging standard deviations hispanic high poverty neighborhoods found protective externalizing behaviors suggesting presence hispanic health paradox also found neighborhood contexts child sex family structure family socioeconomic status amplified dampened effect neighborhood externalizing behaviors results demonstrate importance age dependent neighborhood effects children different demographic profiles respond differently social contexts exposed elsevier ltd rights reserved
thymosin alpha alpha powerful modulator immunity inflammation despite years studies reports evaluating serum alpha health disease studied cohort healthy individuals comparison patients affected chronic inflammatory autoimmune diseases sera blood donors healthy controls patients psoriatic arthritis psa rheumatoid arthritis systemic lupus erythematosus sle attending transfusion medicine rheumatology clinic policlinico tor vergata rome italy tested alpha content means commercial enzyme linked immunosorbent assay elisa kit data analysed relation demographic clinical characteristics patients controls gender difference found group females lower serum alpha levels males patients lower serum alpha levels lowest observed psa group versus groups among patients time blood collection taking disease modifying anti rheumatic drugs dmard plus steroids significantly higher alpha levels taking dmard alone treatment taking steroids alone however whichever type treatment taken patients serum alpha still significantly lower treatment related difference psa group prospective studies necessary confirm deepen observations might improve understanding regulatory role alpha health disease increase knowledge pathogenesis chronic inflammatory autoimmune diseases
paper investigate presence general purpose operating system influences reliability modern embedded systems chips socs experimentally study difference neutron induced error rate socs executing application bare metal without underlying operating system top linux kernel analysis demonstrates linux presence barely affects silent data corruption sdc rate whereas greatly increases system functional interruption sefi rate times preventive measures taken nevertheless experimentally demonstrate cache conflicts operating system application leveraged significantly reduce linux induced sefi rate increase moreover evaluate software stack masking effect show higher abstraction layer application implemented lower sdc rate furthermore analyze system reliability taking account resulting failure rates also execution thus exposure times
background rosacea features increased neurovascular reactivity migraine complex neurologic disorder characterized recurrent episodes headache associated nausea increased sensitivity light sound objective evaluated prevalence risk new onset migraine patients rosacea methods danish individuals years age older linked nationwide registers adjusted hazard ratios hrs estimated cox regression results total cohort patients rosacea baseline prevalence migraine reference population patients rosacea respectively fully adjusted migraine confidence interval patients rosacea patients phymatous rosacea increased risk migraine adjusted confidence interval whereas patients ocular rosacea increased risk adjusted confidence interval notably risk higher among patients age years older younger individuals risk significant among women limitations unable distinguish migraine subtypes conclusion found significantly higher prevalence risk incident migraine especially female patients rosacea data add accumulating evidence link rosacea central nervous system
paper presents original approach aiming obtain optimum configuration offshore wind farm owf thanks cost models take account costs parts electrical network optimization platform based genetic algorithm also allows evaluate reliability owf approach used compare topologies obtained different cases real owf banc guerande selected design owf compared results obtained using different methods cost optimization cost reliability optimization optimization results show ring topologies give interesting results total cost including expected energy supplied lifetime owf taken account number offshore substations positions also considered optimization show introduction substations order obtain better performances possible reasonable cost presented optimization tool help design farms taking account several constraints
background aims familial hypercholesterolaemia autosomal dominant disease frequency leads premature coronary heart disease new approaches identify mutation carriers early needed prevent premature cardiac deaths cross sectional study avon longitudinal study parents children alspac evaluated biochemical thresholds screening childhood modelled two stage biochemical sequencing screening strategy detection methods alspac children cholesterol measurement age nine years genetic diagnosis performed individuals using whole genome targeted sequencing known causing genes detection rate false positive rate fpr proposed screening thresholds total cholesterol ldl multiples median mom assessed results six sequenced individuals causing mutation five ldl mom giving verification bias corrected fpr cut point mom fpr estimated expected mutation carriers parental carriers could detected every children screened false positives reliably excluded addition next generation sequencing step biochemical screen positive samples conclusions proposed cholesterol thresholds childhood screening less accurate previously estimated sequential strategy biochemical screening followed targeted sequencing genes screen positive children may help mitigate higher previously estimated fpr reduce wasted screening unaffected parents authors published elsevier ireland ltd
describe developed computerized data bank strength materials contains data physico mechanical characteristics numerous structural materials wide range loading operation conditions structure data bank description management system presented data bank multipurpose data processing complex intended solving practical problems assessment justification life main components assemblies units used modern engineering structures criteria strength reliability lifetime
combined cooling heating power cchp system plays significant role efficient usage energy field small scale power system application ranging residence utilities paper new cchp system proposed consists power generation unit pgu absorption chiller storage tank ground source heat pump gshp substitute conventional electric chiller auxiliary boiler supply deficient cooling heating load study three basic load following strategies following electric load fel following thermal load ftl following hybrid load fhl employed analyze annual total cost atc operational cost cost carbon dioxide emissions cde primary energy consumption pec based case study regional energy system sino singapore eco city evaluated case carbon tax electricity feed tariff considered compare performances following maximum electric efficiency pgu max eff strategy results show proposed system performed well cost cde pec reduction atc increased except max eff strategy carbon tax electricity feed tariff carbon tax electricity feed tariff considered performances max eff strategy best otherwise application fel better finally max eff fel strategy sensitivity analysis performed results presented varying electricity gas price elsevier ltd rights reserved
recent embodied theories meaning known simulation semantics posit language comprehension engages even amounts mental simulation meant language comprehension however deviates perspectives interpersonal communication adhered researchers social psychology interactional linguistics paper outline four alternative perspectives comprehension spoken interaction highlights factors remained largely outside current purview simulation theories include perspectives language comprehension terms striving inter subjective conformity recognition communicative intentions iii prediction anticipation dynamic environment integration multimodal cues contrasting views simulation theories comprehension outline number fundamental differences terms kind process comprehension assumed passive event like versus active continuous well kind stimulus language assumed comprising unimodal units versus multimodal distributed across conversational turns finally discuss potential points connection simulation semantics research spoken interaction touch methodological implications interactive multimodal reappraisal simulation semantics
titanium dioxide also known titanium oxide titania found nature widely used paints coatings plastics foods cosmetics skin care products medicine study male adult zebrafish individuals exposed different doses titanium dioxide nanoparticles acute sub chronic exposure effects titanium dioxide nanoparticles testis tissues evaluated histological methods addition roles titanium dioxide nanoparticle exposure apoptosis revealed tunel method titanium dioxide exposure inhibits spermatogenesis cause cell death spermatogenic cells first time proved study depending dose amounts increase number sperm cells spermatogonia spermatocytes began disappear detected
investigate effect solifenacin succinate intraocular pressure iop dry eye patients overactive bladder oab study conducted prospectively october november total female oab patients mean age years range years evaluated full ophthalmic examination including schirmer test iop measurements conducted solifenacin succinate day started orally procedures repeated week follow effects side effects documented statistically significant difference observed iop tear secretion values baseline day week oab patients using solifenacin succinate solifenacin succinate treatment terminated patients owing dry eye patient increased iop patient systemic side effects patient constipation dry mouth various rates common systemic side effects observed solifenacin succinate useful eliminating oab symptoms female patients cause systemic side effects significant side effects tear secretion schirmer iop concluded solifenacin succinate could reliably used pure oab patients without comorbidity terms dry eye iop believe prospective studies larger series still needed reach definite conclusion
number resistive switching memories exhibit activation based dynamical behavior makes suitable neuromorphic programmable analog filtering applications boundary condition memristor bcm model accounts tunable activation thresholds boundary states quantitatively accurate description kinds memristors investigation circuit applications paper introduces generalized boundary condition memristor gbcm model preserving features bcm model allowing hoc tuning activation based dynamics enables appropriate modulation conditions memristors may operate storage elements data processors simple circuit implementation novel model presented time efficient simulations confirming improvement modeling accuracy bcm model shown proof concept suitability gbcm model exploration full potential memristors neuromorphic circuits programmable analog filters paper adopts model fundamental synaptic rules governing mechanisms learning neural systems gain insight key issues design couple filters copyright john wiley sons ltd
studied mango glutathione transferase gst mangifera indica bound glutathione gsh hexyl glutathione gsx gst tau class migstu molecular mass kda migstu michaelis menten kinetic constants determined substrates obtaining max cat cdnb min respectively min reduced gsh respectively migstu micromolar affinity towards gsh gsx crystal structure migstu apo bound gsh gsx generated model explains thermodynamic signatures binding showed importance enthalpic entropic compensation ligand binding tau class gst enzymes elsevier societe francaise biochimie biologie moleculaire sfbbm rights reserved
mood spectrum disorders bipolar disorder recurrent depressive disorder seasonal affective disorder accompanied circadian deregulations occur acute mood episodes well euthymic periods particularly common among bipolar patients remission suggests altered circadian rhythms may biological markers disorders rhythm dysfunctions observed mood disorder patients using actigraphic measures assessing social metric rhythms diurnal preferences melatonin secretion since many markers heritable therefore driven clock genes genes may represent susceptibility factors mood spectrum disorders indeed several genetic association studies suggested certain circadian gene variants play role susceptibility disorders connections circadian genes clock arntl npas per nrd repeatedly demonstrated bipolar disorders lesser extent recurrent depressive disorders seasonal affective disorders study circadian phenotypes circadian genes mood spectrum disorders represents major field research may yet reveal pathophysiological determinants disorders elsevier ecnp rights reserved
backgroundchanges intestinal motility likely contribute irritable bowel syndrome ibs pathophysiology aim study investigate effects ibs mucosal supernatants human colonic muscle contractility methodssupernatants obtained biopsies ibs patientsnine constipation ibs nine diarrhea predominant ibs ibs nine asymptomatic subjects used controls colonic circular smooth muscle strips isolated cells smc exposed control ibs supernatants spontaneous phasic contractions strips morphofunctional parameters cells evaluated basal conditions response acetylcholine ach incubation ibs supernatants also conducted presence antagonists inhibitors namely histamine protease prostaglandin antagonists nuclear factor kappa inhibitor catalase nadph oxidase inhibitor camp cgmp cyclase inhibitors key resultsexposure ibs ibs supernatants induced significant reduction basal tone ach elicited contraction muscle strips significant shortening impairment ach contraction smcs nadph oxidase inhibitor prevented effect supernatants protease antagonist ibs effect effect observed antagonists inhibitors dilution ibs supernatants partially restored effects smcs whereas dilution ibs supernatants significantly reverted effects muscle strips ach elicited response smc conclusions inferencessupernatants mucosal biopsies ibs patients reduce colonic contractility observed impairment concentration dependent likely occurring intracellular oxidative stress damage involving different neuromotor mechanisms depending ibs subtype
efficacious treatments seasonal affective disorder include light therapy seasonal affective disorder tailored form cognitive behavioral therapy using data parent clinical trial secondary analyses examined relationship cognitive change treatment cognitive behavioral therapy light therapy combination treatment mood outcomes next winter sixty nine participants randomly assigned weeks cognitive behavioral therapy light therapy combination treatment cognitive constructs dysfunctional attitudes negative automatic thoughts rumination assessed pre post treatment dysfunctional attitudes negative automatic thoughts rumination improved acute treatment regardless modality however participants randomized solo cognitive behavioral therapy greater degree improvement dysfunctional attitudes automatic thoughts uniquely associated less severe depressive symptoms next winter change maladaptive thoughts acute treatment appears mechanistic solo cognitive behavioral therapy enduring effects next winter simply consequence diminished depression light therapy combination treatment
last years cost ease massively parallel sequencing mps reduced dramatically point considered tool use forensic case work important consideration implementation new forensic technology ability remain compatible previous technology study sequenced amplicons two commercial forensic short tandem repeat str multiplexes ampflstr identifiler powerplex using illumina miseq ion pgm sequencer life technologies characterised sequence data forensic perspective using mps data platforms determined str genotypes forensic samples found previously undocumented sequence variation seven str alleles characterising features dna sequence profiles stutter locus imbalance identified areas future development needed prior casework implementation rapid development technology meant many forensic community left behind also provide explanation forensic scientists happening different stages mps workflow library preparation bioinformatics may affect results
one dimensional monatomic chains promising candidates technical applications field nanoelectronics due unique mechanical electrical optical properties particular investigate mechanical properties including young modulus ultimate strength ultimate strain necessities stability materials car parrinello molecular dynamics work comparative studies alternating carbon nitrogen chain carbon chains carbyne different lengths show carbon nitrogen chain obviously stronger stiffer carbynes thus chain found decomposition products nitromethane explosive simulations could superior nano mechanical material carbyne chain furthermore found bond order weakest bond monatomic chains positively correlated young modulus ultimate strength materials
background access antiretroviral therapy art africa increased dramatically concerns raised regarding patient attrition important measure program quality methods examined aggregate data patients initiating art successive cohorts facilities african countries period characterized massive treatment expansion poisson regression assessed trends month cohort attrition proportion patients cohort longer receiving art initiating facility calendar time art services matured identified factors associated attrition results across countries month cohort attrition respectively decrease calendar time month month art services matured month month additionally attrition remained stable decreased across measures nearly countries initiating art facilities documented transfers fewer women art cohorts poor count documentation lower median count art initiation associated increased month attrition increased month attrition observed semiurban facilities documented transfers cohorts poor count documentation whereas higher patient load associated decreased attrition conclusions stable decreasing trends attrition art patients observed countries suggesting programs expanded without compromising quality however reductions attrition needed maximize individual population benefits art
glial cell line derived neurotrophic factor gdnf widely recognized survival factor dopaminergic neurons gdnf also shown promote development differentiation protection central nervous system neurons thought play important role various neuropsychiatric disorders severe mood disorders primarily major depressive disorder bipolar affective disorder attract particular attention psychopathologies characterized structural alterations accompanied dysregulation neuroprotective neurotrophic signaling mechanisms required maturation growth survival neurons glia main objective review summarize recent findings evaluate potential role gdnf pathogenesis treatment mood disorders specifically describes implication gdnf mechanism depression effect antidepressant drugs mood stabilizers interrelation gdnf brain neurotransmitters playing key role pathogenesis depression review provides converging lines evidence brain gdnf contributes mechanism underlying depressive disorders effect antidepressants mood stabilizers cross talk gdnf neurotransmitters representing feedback system gdnfneurotransmitters neurotransmitters gdnf
almost common sense work stress leads sleep impairment question work related stressors impair employee sleep remains open study focuses role rumination underlying mechanism sleep impairment specifically authors contribute recent research differentiating affective rumination problem solving pondering examine impact forms rumination stressor sleep relationship following theories rumination zeigarnik effect focus unfinished tasks key onset rumination unfinished tasks received much research attention memory context neglected stressor impact recovery drawing theory differential indirect links unfinished tasks sleep affective rumination versus problem solving pondering examined number unfinished tasks extending month period may impair employee sleep unfinished tasks within acute phase study intraindividual links diary study supplemented depicting person effects unfinished tasks period months examined authors matched friday monday observations week interval employees results multilevel analysis suggest within person relationship unfinished tasks sleep mediated affective rumination although problem solving pondering negatively related sleep impairment indirect effect significant finally beyond acute effect authors found higher levels unfinished tasks months related increased sleep impairment weekend
prostate cancer pca second leading cause cancer death men however reliable tools detection localization still lacking dynamic contrast enhanced ultrasound dce diagnostic tool suitable analysis vascularization imaging intravenously injected microbubble bolus localization angiogenic vascularization associated development tumors particular interest recently methods analysis bolus convective dispersion process shown promise localize angiogenesis however independent estimation dispersion possible due ambiguity convection dispersion therefore study propose new method considers vascular network dynamic linear system whose impulse response locally identified end model based parameter estimation employed permits extraction apparent dispersion coefficient velocity peclet number system clinical evaluation using data recorded patients shows proposed method applied effectively dce able locally characterize hemodynamics yielding promising results receiver operating characteristic curve area prostate cancer localization elsevier rights reserved
objective identify barriers enablers prevention mother child transmission pmtct hiv program china methods systematic review existing literature regarding barriers enablers implementation pmtct program china performed checklist sure guidelines supporting use research evidence used synthesize barriers enablers supporting strategies analyze relationships hiv testing rate vertical transmission rate antiretroviral treatment art acceptance rate among hiv infected women infants also extracted included studies assess effectiveness enablers results initially publications identified ultimately articles included eighteen types barrier nine types supportive strategy identified mainly level social political issues healthcare recipients healthcare providers healthcare system based government oriented multi sector cooperation enablers china included community hospital family promotion comprehensive financial support service recipients free hiv testing marriage registration opt model one one service model conclusions experience china suggests government role coordination acceptability accessibility service primary concerns regard pmtct project author
background examine differences associated characteristics prescription drug use occurring unipolar bipolar disorders patients eating disorders eds methods patients eds major depressive episode mde recruited psychiatric outpatient clinics interviewed completed self administered measures assessing eating general psychopathology prescribed drugs index outpatient visit recorded clinical characteristics prescription drugs groups major depressive disorder mdd mde lifetime mania mde lifetime hypomania compared continuous variables groups compared using generalized linear regression adjustments age gender subtype pair wise comparisons multivariate logistic regression adjustments age gender subtype employed estimate adjusted odds ratios confidence intervals groups results two hundred twenty seven patients eds current mde among experienced associated manic hypomanic episodes respectively bipolar patients displayed significantly poorer weight regulation severe impulsivity emotional lability higher rates occurring alcohol use disorders mdd patients patients found lowest poorest working memory severe depression suicidality functional impairment among patients patients shared affect behavioral dysregulations less severe degrees cognitive functional impairments patients significantly less likely mdd groups antidepressant monotherapy great rate individuals taking antidepressant monotherapy potential risk mood switch course treatment conclusions study identified discriminative features bipolar disorders mdd among group depressed patients suggest associated mania hypomania mood lability predictors clinical severity identified patients presented depressive features accurate diagnosis bipolar disorders may implications pharmacotherapy patients eds
background high hospitalization rate diabetic patients since retinopathy albuminuria important manifestations microvascular disease diabetes aim investigate effect retinopathy albuminuria long term mortality type diabetic inpatients observational cohort study methods type diabetic inpatients given primary diagnosis poor glucose control consecutively enrolled hospitalization periods clinical information collected review patient medical records mortality data obtained national registry taiwan results total type diabetic inpatients enrolled study median follow period years interquartile range years patients albuminuria retinopathy albuminuria retinopathy albuminuria retinopathy groups significantly higher risks cause mortality cardiovascular mortality albuminuria retinopathy group however among patients albuminuria significant difference cumulative mortality without retinopathy decrease estimated glomerular filtration rate egfr retinopathy independent predictor allcause mortality cardiovascular mortality type diabetic inpatients albuminuria conclusions albuminuria type diabetic inpatients strong predictor long term mortality discharge hospital retinopathy independent predictor mortality type diabetic inpatients without albuminuria albuminuria low egfr better predictor mortality retinopathy type diabetic inpatients albuminuria
objectives smokers posttraumatic stress disorder ptsd increased difficulty achieving maintaining abstinence contingency management approaches smoking cessation interventions demonstrated short term efficacy limited high rates relapse goal pilot study evaluate usability feasibility smartphone based smoking cessation application stay quit coach designed prevent relapse among individuals ptsd methods smokers randomized quitever intervention combining mobile contingency management smoking cessation counseling medications stay quit coach contact control condition identical quitever except stay quit coach included primary outcome prolonged smoking abstinence results among queried follow periods average stay quit coach helpfulness ratings high ranged point likert scale higher scores corresponding greater helpfulness stay quit coach rated participants effective helping quit smoking helping remain quit providing support relevant information quitting among three quitters quitever group reported abstinence months however abstinence bioverified one quitter months among four quitters contact control condition group three reported abstinence months abstinence confirmed bioverification conclusions smokers ptsd express interest helpfulness stay quit coach remaining abstinent quit attempt combined use mobile contingency management stay quit coach feasible acceptable adjunctive smoking cessation treatment reducing smoking among smokers ptsd adequately powered clinical trials needed demonstrate long term efficacy combined approach smoking cessation study use technological advances prevent smoking relapse among smokers ptsd quitever registered www clinicaltrials gov clinicaltrials gov identifier nct
aim study determine effects psychoeducation received family members patients first episode schizophrenia expressed emotion family functioning family members study quasi experimental design control group sample study family members experimental control patients first episode schizophrenia experimental group received weeks psychoeducation group family functioning assessed beginning end psychoeducation program criticism hostility involvement protecting intervention levels family members decreased end psychoeducation family functioning changed end psychoeducation assessed healthy consequently early psychoeducational groups may effective decreasing level improving family functioning family member patient first episode schizophrenia
polymeric drag reducers partially hydrolysed polyacrylamide phpaam important chemical additives hydraulic fracturing fluids significantly decrease frictional pressure drop casing resulting increase injection rate delivered fracturing point incorporation sodium acrylamido methylpropane sulphonic acid naamps moieties polyacrylamide paam improve performance fracturing fluids addressing compatibility issues related use phpaam sensitivity water salinity study three types poly acrylamide naamps pure phpaam investigated respect polymer induced drag reduction mechanical polymer degradation turbulent pipe flow pressure driven pipe flow facility test section comprised horizontal bore circular cross section pipe facility modified order allow long time length experiments automatically recirculating polymer solution closed loop test section presence naamps groups copolymer backbone found increase ability phpaam reduce frictional drag vulnerability mechanical degradation remains unaffected drag reduction naamps copolymer solutions described modified version virk correlation extended include effect reynolds number polymer mechanical degradation found proceed friction reducer almost ineffective reducing drag phenomenon contrast common correlation polymer degradation predicts existence asymptotic finite limit reduced drag reduction authors published elsevier ltd
reentry process hypersonic vehicles unavoidable uncertainties always crucially impact trajectory performance therefore even variable robust design algorithms proposed areas reference trajectory design guidance algorithm design effect analysis uncertainties still needs carefully taken paper deviation condition strategy dcs developed applied rank uncertainty effects proposed approach given uncertainties appended open loop control process regularly according orthogonal experiment design resulting system outputs scientifically analyzed via proper performance evaluation approach aiming order uncertainty effects simulation methodology illustrated utilizing classic case reentry vehicles compared conventional methods proposed strategy significantly reduces amount calculation evaluations work provides reference information uncertainties facilitate robust design process somewhat
mixed results reported anticorrosion graphenecoated metal surfaces graphene serves effective short term barrier corrosion oxidation due low permeability gases galvanic cell graphene metal substrate facilitates extensive corrosion long run defects graphene layer provide pathways permeation oxidizing species study role defects graphene anticorrosion using first principles theoretical modeling experiments highly reactive environment indicate oxidized products primarily distribute along grain boundaries graphene analyze thermodynamics absorption grain boundaries graphene basis density functional theory insertion vacancy sites energetically favorable interstitial impurities facilitate structural transformation graphene significantly decrease mechanical strength graphene layer furthermore presence interstitial oreduces chemical stability graphene enhancing vacancies promoting dispersive growth corrosive reactants along grain boundaries
objective present study based previously reported successful randomized controlled trial rct acceptance commitment group therapy act severe health anxiety investigates intervening variables act process primarily targeted act psychological flexibility randomized study yet examined possible intervening variables act methods patients diagnosed severe enrolled rct included analyses outcome measure illness worry whiteley index included process variables facets mindfulness results statistically significant indirect effects act outcome illness worry months treatment found bca one mindfulness subscale namely ton react bca conclusion line act model change may small moderate decrease illness worry mindfulness scales non react showed significant although tentative due active comparison control condition results support intervening variable act treatment aimed reducing illness worry patients severe elsevier ltd rights reserved
past research shown gender typicality applicants faces affects leadership selection irrespective candidate gender masculine facial appearance congruent masculine typed leadership roles thus masculine looking applicants hired certainly feminine looking ones present study extended line research investigating hiring decisions masculine feminine typed professional roles furthermore used eye tracking examine visual exploration applicants portraits results indicate masculine looking applicants favored masculine typed role leader feminine looking applicants feminine typed role team member eye movement patterns showed information gender category facial appearance integrated first fixations portraits hiring decisions however based initial analysis occurred second stage portrait viewed context considering applicant specific job
objective goals meta analysis investigate overall effectiveness cognitive behavioral group therapy cbgt depression relapse prevention depression investigate variables episode residual symptoms group size control group group manual therapist experience therapy frequency session length take home assignment cbgt study could affect effect size method study collected actual study designs sought cbgt depression published studies cross referenced using medical subject headings mesh following keywords group therapy cognitive therapy cognitive behavioral therapy cognitive behavioral group therapy psychotherapy depression relapse recurrence quality studies evaluated using cochrane collaboration guidelines effect size cbgt depression relapse prevention depression used formula devised hedges olkin results study investigated results studies effect cbgt depression cbgt immediate continuous effect months continuous effect months cbgt lowered relapse rate depression variables significantly different terms immediate effect cbgt versus usual care therapy sessions lasting longer hour take home assignments preintervention severity depression patient turnover rate found significantly related size immediate effect relapse rate months significantly related participants residual symptoms participants mention residual symptoms conclusions researchers clinicians take note cbgt moderate effect level depression small effect relapse rate depression results study suggest patient receive course therapy least every months
aimslow gait speed associated mortality poor physical function disability older people aim evaluate association slow gait speed rapid cognitive decline among oldest old men taiwan methodswe carried longitudinal cohort study veterans retirement community enrolled male residents aged years older slow gait speed defined rapid cognitive decline defined mini mental state examination mmse decline points year body mass index charlson comorbidity index handgrip strength gait speed mini mental state examination datasets collected logistic regression model built evaluate association fast cognitive decline slow gait speed resultsin residents mean age years recruited including rapid cognitive decline univariate analysis showed slow gait speed could predict rapid cognitive decline adjusting age charlson comorbidity index polypharmacy psychiatric drug usage cigarette smoking experience baseline cognitive function depressive mood handgrip strength nutritional status history fall slow gait speed still independently associated rapid cognitive decline adjusted conclusionsslow gait speed thus independent predictor rapid cognitive decline oldest old men veterans retirement community taiwan geriatr gerontol int suppl
paper presents study influence geotextile encasement behaviour soft soils improved fully penetrating encased columns influence analysed means measuring soil column stress distribution pore pressures soil deformation consolidation process purpose horizontal slice representative unit cell analysed means small scale laboratory tests tests carried large instrumented rowe barden oedometric cell results showed vertical stress supported encased columns times sustained non encased ones stress concentration factor encased columns clearly higher obtained tests non encased columns finally improvement relation settlements presented ratio settlement soils reinforced ordinary encased columns settlement non treated soft soil settlement reduction factor around soil treated encased columns soil non encased columns elsevier ltd rights reserved
snow load strength excellent ventilation strong end wall construction structure mobility rainwater harvesting high tunnel features important urban growers rural farmers interested features high tunnels working include features single structure urban growers led innovations benefit urban rural farmers rainwater harvesting mobile ready base frame weather retractable dome two person installation method innovations developed cleveland ohio innovations applied small farms throughout northeast ohio serious concern environmental human health represented increasing copper occurrence agricultural soils andwaters possible food contamination bioaugmentation along trophic chain request decontamination different matrices environmentally sustainable technology phytoremediation addressed selecting plant materials improved pollutant tolerance removal capability purpose plants hybrid poplar clone monviso populus generosa henry nigra grown growth chamber hydroponics exposed excess concentrations selected times higher allowed italian regulation water use results evidenced notable tolerance poplar plants particularly lowest concentration organ level root system themost affected treatment especially exposed plants copper determinations revealed metal mostly bioaccumulated roots limited amount reaching shoots chlorophyll content fluorescence analyses confirmed visible symptoms leaves highlighting good physiological status exposed plants contrarily impairment themain processes associated photosynthesis observed exposed plants also gas exchange measurements remarkably content analysis spiked water solutions revealed poplar plants succeeded removing almost total amount added results strengthen evidence poplar plants represent useful eco friendly bio tool decontamination metal polluted waters elsevier rights reserved
paper presents control oriented modeling approach multi zone buildings mixed mode cooling based linear state space representation varying coefficient matrices key features time variant thermal resistances associated heat extraction due airflow calculated using airflow network model approach validated experimental data collected two zone test building four operation modes forward linear time variant state space ltv model developed based first principles used true representation building identify parameters low order ltv gray box model low order model predict building thermal dynamics sufficient accuracy root mean square error rmse degrees air degrees area weighted mean surface temperature south direct gain zone furthermore study develops progressive refinement prore optimization method following multi level optimization topology branch bound decision trimming strategy find sequences binary open close decisions motorized windows due significant improvement computing time models algorithms presented paper enable long term simulation mpc performance evaluation implementation predictive strategies real controllers elsevier ltd rights reserved
objective evaluate long term safety effectiveness tadalafil patients pulmonary arterial hypertension pah real world clinical practice methods prospective multicenter noninterventional post marketing surveillance included patients pah observed years initiation tadalafil safety assessed analyzing frequency adverse drug reactions adrs discontinuations due adverse events aes serious adverse drug reactions sadrs effectiveness measurements included assessment change world health organization functional classification pah minute walk test cardiac catheterization echocardiography results among patients analyzed safety overall incidence adrs common adrs headache diarrhea platelet count decreased anemia epistaxis nausea flushing hepatic function abnormal hot flush myalgia common sadrs cardiac failure interstitial lung disease worsening pah platelet count decreased among patients analyzed effectiveness percentages patients improvement functional class months year years initiation tadalafil last observation respectively observation points except pulmonary regurgitation pressure gradient end diastole months mean minute walk distance cardiac catheterization echocardiogram measurements showed statistically significant improvement conclusion surveillance demonstrated tadalafil favorable safety effectiveness profiles long term use patients pah japan
background aims irritable bowel syndrome ibs characterized chronic abdominal pain discomfort accompanied abnormal bowel movements sensitized subjects ingested nickel may induce gastrointestinal symptoms similar ibs addition typical systemic cutaneous lesions systemic nickel allergy syndrome snas low nickel diet could improve systemic manifestations evaluated prevalence nickel allergy ibs effects low diet gastrointestinal symptoms control intestinal barrier function quality life psychological status patients ibs sensitized patients methods twenty consecutive patients affected ibs suspected snas underwent intestinal permeability tests gastrointestinal symptoms evaluated using visual analogue scale months low diet subjects increased intestinal permeability baseline repeated nuclear examination diet results frequent profile diarrhea predominant ibs low diet induced significant constant improvement gastrointestinal symptoms equally significant improvement visual analogue scale mean urinary output chromium ethylene diamine tetra acetate edta significantly different control group conclusion pilot study shows low diet improves gastrointestinal symptoms patients ibs snas
information distribution forest types land cover classes essential decision making significant climate regulation biodiversity conservation societal issues approach combination advanced polarimetric decompositions textures advanced land observing satellite phased array band synthetic aperture radar full polarimetric data purpose forest type classification proposed using support vector machine svm classifier classified forest types selected indian region tested classification performance wishart method forest types classified results assessed confusion matrix based statistics results suggest incorporation various polarimetric decompositions features gray level occurrence matrix textures refines svm classification overall accuracy wishart supervised classification algorithm kappa observed integration polarimetric information textures give complimentary information forest type discrimination produce high accuracy maps approach overcomes limitations optical remote sensing data continuous cloud coverage areas society photo optical instrumentation engineers spie
chinese style cooking often involves volatilization oils potentially produce large number pollutants adverse impact environment human health therefore reviewed published studies associated research topic among mainland china hong kong taiwan involving studies roles food ingredients oil type cooking style impacting generated pollutants human health highest concentration occurred including peat wood raw coal used stoves olive oil adopted cooking high temperatures without cleaning technology conclude concentrations cooking emissions voc concentrations varied barbeque produced greatest mass concentrations compared sichuan cuisine canteen restaurants pah concentration emitted exhaust stacks dining area kitchen ranged largest amount gaseous pollutants emitted recorded incomplete combustion fuel low combustion efficiency observed variation range respectively regards toxicity exposure current findings concluded dose exposure time significant factors considered scientific research area mainly driven comparison among emissions various ingredients cooking techniques still need comprehensive studies fully characterise cooking emissions including physical chemical transformations crucial accurate estimation impacts environment human health elsevier rights reserved
young children exert little control household tobacco smoke exposure considered developmental neurotoxicant using quebec longitudinal study birth cohort examine prospective associations early childhood smoke exposure later antisocial behavior parents children reported presence household smokers seven follow ups ages age children self reported five aspects early antisocial dispositions adjusting confounders every standard deviation increase household smoke exposure prospectively associated standard deviation unit increase conduct problems confidence interval standard deviation unit increase proactive aggression standard deviation unit increase reactive aggression standard deviation unit increase school indiscipline standard deviation unit increase dropout risk long term findings warrant fostering parental awareness developmental risks policy makers health practitioners school curricula equally integrate ideas curriculum
objective study test whether difference chronic rhinosinusitis patients crswnp without crssnp nasal polyps association extent disease scans symptom severity health related quality life hrql impairment data sets chronic rhinosinusitis crs patients completed sino nasal outcome test snot visual analog scale vas scores subjected principal component analysis pca identify symptom components related crs controlling demographics medical therapy comorbidities association symptom components items excluded pca lund mackay score lms evaluated association found total snot score lms crs patients independent association higher nasal symptom component derived snot pca lms patients crswnp crssnp patients statistically significant difference two patient subsets patients crssnp higher worse snot facial pain associated lower lms although estimated change lms modest considering vas pca components higher nasal symptoms associated higher lms crswnp patients crssnp statistically significant difference crs groups higher pain pca component associated lower lms crssnp patients study found significant differences relationship symptom burden scores crs phenotypes association hrql impairment scores
objectives evaluate cannabinoid receptors cbrs expression peripheral immune cells blood monocytes neutrophils lymphocytes cells relationship wide range serum cytokine levels subjects schizophrenia controls methods sample people chronic schizophrenia controls enrolled study expression cannabinoid receptors cbr cbr evaluated peripheral blood leukocytes flow cytometry serum levels cytokinesichemokines simultaneously analyzed cytometric bead array results found higher expression cannabinoid receptors cells innate immune system subjects schizophrenia compared controls serum levels interleukin interferon ifn motif ligand interferon gamma induced protein cxcl decreased levels chemokine motif ligand monocyte chemoattractant protein ccl mcp increased schizophrenia group comparison controls patients schizophrenia showed simpler correlation network cytokines cbrs expression controls conclusion patients schizophrenia showed increased cbrs expression cells innate immune system simpler correlation network cytokines cbrs expression compared controls results suggest defective endocannabinoid system mediated immunomodulation patients schizophrenia elsevier ltd rights reserved
cape gooseberry fruit plant physalis peruviana gained commercial scientific interest contents health promoting compounds integral approach estimate shelf life cape gooseberry conducted taking account physicochemical microbiological nutritional changes consumer acceptance experiments performed independent harvest times two years conditions storage temperatures degrees relative humidity fruit without calyx packed polyethylene terephthalate pet trays polypropylene baskets respectively experiment conducted total shorter fruit spoilt earlier fruit calyx showed longer shelf life degrees temperature gave longer shelf lives irrespective calyx presence critical quality attribute shelf life without calyx fungal growth determined consumer acceptance weight loss critical quality attribute fruit calyx studying various quality attributes integral way appeared give better understanding shelf life published elsevier ltd
infectious diseases emerging reemerging almost every year trend continue number factors including increased global population aging travel urbanization climate change favor emergence evolution spread new pathogens approach used far emerging infectious diseases eids work technical point view sustainable however advent platform technologies offers vaccine manufacturers opportunity develop new vaccines faster reduce investment build manufacturing facilities addition allowing possible streamlining regulatory processes new technologies also make possible rapid development human monoclonal antibodies could become potent immediate response emergency far several proposals approach eids made independently scientists private sector national governments international organizations world health organization merit need global governance capable taking strong leadership role making attractive partners come table coordinate global approach
formulate elicit bayesian belief networks bbns assessing possible characteristics german new passenger car fleet including market shares different vehicle types emissions user costs abatement costs internal combustion engine vehicles including hybrid electric vehicles ice plug hybrid electric vehicles phev battery electric vehicles bev seven technology environmental experts german original equipment manufacturers oem sector elicited key relationships conditional probability values model yielding seven distinct bbns able predict different future technology economic policy scenarios influence model projections scenarios include differing amounts technological advancement battery development regulation fuel electricity greenhouse gas intensities across expert models baseline fleet greenhouse gas emissions predicted new fleet emissions reduced emissions new fleet combination higher share renewables electricity mix larger share biofuels fuel mix stricter regulation car emissions european union experts bbns predict ice lower user costs per kilometer phev bev scenarios ice remain dominant vehicle type german new fleet according experts bbns abatement costs negative ice scenarios positive negative phev bev depending expert model scenario assumed critical areas expert models agree differ serve highlight reductions uncertainty regarding future technology economic environmental regulatory relationships needed improve ability predict anticipate future vehicle fleet composition vehicle performance elsevier ltd rights reserved
context functional movement screen fms evaluates performance fundamental movement patterns using point scale previous studies reported increased injury risk composite score less studies limited specific sports injury definition objective examine association fms movement pattern scores acute noncontact overuse musculoskeletal injuries division college athletes exploratory objective assess association injury fms movement pattern asymmetry design prospective cohort setting college athletic facilities participants injury free college basketball football volleyball cross country track field swimming diving soccer golf tennis athletes males intervention fms administered preparticipation examination main outcome measure noncontact overuse injuries required intervention athletic trainer sport season results fms different injured point roc curve maximized sensitivity specificity therefore previously published cut point used analysis injury adjustment statistically significant association fms injury odds ratio existed lunge movement pattern associated injury scoring less likely injury scored also association fms movement pattern asymmetry injury conclusion fms movement patterns asymmetry poor predictors noncontact overuse injury cohort division athletes
unmanned aerial vehicle uav technology developed multi purpose aircraft system several applications many fields military agriculture surveillance others since rotorcraft vehicles generally unstable active attitude stabilization controller becomes important part uav systems paper introduces design optimal pid controller improve attitude stabilization four rotor vertical take landing vtol uav known qaudrotor aircraft proposed controller utilizes differential evolution optimization algorithm tune parameters classical controller comparison made tuned pid controller based ziegler nichols tuning method fuzzy pid controller based expert experience tind optimal range arid shape fuzzy membership functions tuned pid controller based genetic algorithm results show superiority proposed controller simulation results obtained using matlai program results assessed terms dine domain factors quadrotor response overshoot rise time settling time steady state error
fine grained scale gibbs entropy isolated system remains constant throughout dynamical evolution consequence liouville theorem hamiltonian systems appears contradict second law thermodynamics reality however problem since thermodynamic entropy associated boltzmann entropy non equilibrium systems different gibbs entropy boltzmann entropy accounts microstates accessible given initial condition compatible given macrostate sense boltzmann entropy coarse grained version gibbs entropy decrease dynamical evolution macroscopic system paper explore entropy production systems long range interactions unlike short range systems thermodynamic limit probability density function systems decouples product one particle distribution functions coarse grained entropy calculated explicitly find characteristic time entropy production scales number particles alpha alpha thermodynamic limit entropy production takes infinite amount time
capturing visual human centered information fundamental input source effective successful human robot interaction hri dynamic multi party social settings torso head pose forms nonverbal communication support derivation people focus attention key variable analysis human behaviour hri paradigms encompassing social aspects towards goal developed model based approach torso head pose estimation overcome key limitations free form interaction scenarios issues partial intra inter person occlusions proposed approach builds concept top view projection tvr uniformly treat respective body parts modelled cylinders body part number pose hypotheses sampled configuration space pose hypothesis evaluated scoring function hypothesis best score yields assumed pose location joints refinement step head pose applied based tracking facial patch deformations compute horizontal plane rotation overall approach forms one core component vision system integrated robotic platform supports socially appropriate multi party multimodal interaction bartending scenario results robot environment real hri experiments varying number users attest effectiveness approach
focusing three recent british film television crime dramas holmes fear english language version ofwallander bbc article argues older men texts site contemporary social cultural anxieties ageing dementia played highly gendered ways link social philosophical reflections power autonomy selfhood dramas different affective orientation tone nonetheless produce reflections meanings memory loss within figurations masculinity crime genre broader significance thinking representational dilemmas dementia
study computer graphics discussed collected image sensor analog electrical signal acquisition image space relative camera system different viewpoints goals cause target respect change orientation imaging system attitude change target imaging system images showed target image change viewpoint target space relative movement imaging system change target rotation translation scale need find construct sort goal order make motion target image features change features feature amounts called invariance invariants invariance reflect characteristics type target nature differences different modes visual information space target location attitude independent according people easy find right target
since earlier days failures encountered structures machines mainly due material fatigue dynamic behaviour beam may change cracks begin appear knowledge changes dynamic individualism important crack detection well structure machine design paper deals systematic study free vibration euler bernoulli beam containing open edge transverse cracks study two springs steel materials considered effect top side cracks bottom side cracks natural frequency cantilever beam discussed natural frequency cracked case cantilever beam investigated numerically using analysis software ansys experimental work done using dewefrf investigate natural frequency cracked beams strong validation numerical results results study suggest average value natural frequencies top side cracked beams identical average value natural frequency bottom side cracked beams true hence clear dynamic characteristic natural frequency changing configuration cracks either top bottom side beam natural frequencies material comparatively higher side material crack configurations cracked cases damping effect greater also found crack location increases constant crack depth natural frequency increases last location crack depth increases natural frequencies almost remain observed presence top side crack bottom side crack configuration cantilever beam function natural frequency cantilever beam square cross section
design revetment engineering wave action resist wave action pattern top layer filter layer core subsoil often adopted general structure top layer usually single discrete blocks typically accropode blocks four leg square hollow blocks barrier boards also acropode riprap paved rock blocks concrete slabs smaller waves top layer provided many research findings stability widely used engineering setting filter layer top layer lower dike core mainly two functions giving certain permeability minimize hydrodynamic load directly acting lower foundation soil giving certain hydraulic tightness prevent fine sediment lower foundation soil rushed paper focused special filter layer geotextile upper structure coarse aggregate lower structure simulating geotextile different permeability coarse aggregate different size pressure top cover layer side geotextile tested wave actions compared theoretical analysis way permeability geotextile impacts stability top layer studyed research shows lower coarse aggregate geotextile high permeability geotextile permeability get poorer uplift force top layer increased wave action cause damage top layer greater vertical component force block gravity water published elsevier ltd
background acute exacerbation idiopathic pulmonary fibrosis ipf rapid ultimately fatal condition effective treatment established pirfenidone antifibrotic effects ipf however efficacy ipf unclear objectives evaluate efficacy pirfenidone ipf methods retrospectively reviewed medical records ipf patients treated period april april identified extracted ipf patients men women mean age years clinical features outcomes patients treated pirfenidone compared patients treated without pirfenidone excluded patients receive recombinant human soluble thrombomodulin rhtm analyzed data remaining patients men women mean age years clinical features outcomes compared patients treated pirfenidone patients receive pirfenidone results significant differences two groups baseline characteristics except pirfenidone use onset three month survival significantly better patients treated pirfenidone control group univariate analysis nonuse pirfenidone potential risk factor death months hazard ratio patients treated rhtm conclusion regimen pirfenidone combined corticosteroids rhtm may improve survival patients ipf elsevier ltd rights reserved
high rates comorbidity found among eating disorder patients may negatively affect treatment outcome prognosis however shortage studies spain using clinician administered interviews assess rates comorbidity among patients particularly adolescents study aimed evaluate axis psychiatric diagnoses adolescent patients compare patients distinct disorder adolescent onset substance use disorder sud patients considering maternal psychological distress another factor involved prognosis secondary aim examine relationship patient psychological variables niaternal distress depression anxiety cross sectional study included patients sud patients mothers half patients received diagnosis comorbid disorder internalizing problems common among eds externalizing disorders common comorbidities among suds similar findings countries maternal distress associated higher levels depression symptom severity patients differences distress found mothers patients comorbid diagnosis without elevated anxiety depression mothers increase likelihood patients particular primary diagnosis short sud patients presented high rates comorbidity types comorbid diagnoses specific group assessing presence comorbid disorders targeting maternal psychological distress may guide treatment interventions improve patient prognosis elsevier ltd rights reserved
rapid growth silver nanoparticles agnps commercialization increased environmental exposure including aquatic ecosystem reported agnps damaging effects photosynthesis induce oxidative stress toxic mechanism agnps still matter debate present study model aquatic higher plant spirodela polyrhiza found agnps affect photosynthesis significantly inhibit photosystem psii maximum quantum yield effective quantum yield phi psii changes non photochemical fluorescence quenching npq light induced non photochemical fluorescence quenching npq non light induced non photochemical fluorescence quenching showed agnps inhibit photo protective capacity psii agnps induce reactive oxygen species ros mainly produced chloroplast activity ribulose bisphosphate carboxylase oxygenase rubisco also sensitive agnps internalized regardless whether exposure agnps capacity generate ros results support hypothesis intra cellular agnp dissociate high toxic rubisco inhibition leads slowing assimilation consequently solar energy consumption decreases excess excitation energy promotes ros generation chloroplast
gastrointestinal diseases important cause morbidity mortality worldwide include infectious pathologies allergic chronic inflammatory conditions crohn disease ulcerative colitis also functional disorders irritable bowel syndrome treatment sometimes difficult due multiple hypotheses pathologies many factors psychological social genetic recently disorders intestinal microbiota described presence microorganisms intestinal tract described since fiftieth century use biomolecular methods function nature gastrointestinal ecosystem microbiota known important contribution knowledge digestion absortion immunologic protective functions intestinal microbioma organism essential study treatment prevention numerous conditions
ambient air pollution becoming severe worldwide posing serious threat human health fine airborne particles particulate matter show higher cytotoxicity coarse fractions indeed induces cardiovascular respiratory damage however studies evaluated detrimental effect normal human skin used next generation sequencing based rna seq method transcriptome gene ontology enrichment analysis determine harmful influences human normal epidermal keratinocytes david analysis showed significantly enriched terms associated epidermis related biological processes epidermis development keratinocyte differentiation suggesting deleterious effects human epidermis addition ingenuity pathway analysis predicted inflammation related signaling one major induced signaling pathways pro inflammatory cytokines upstream regulators symptoms similar psoriasis downstream effects caused considerable changes expression pro inflammatory cytokines psoriatic skin disease related genes might lead epidermal dysfunctions results might help understand mechanism air pollution induced skin barrier perturbation contribute development new strategy prevention recovery consequent damage elsevier rights reserved
quantitative structure activity relationship qsar models employed successfully prediction small model protein chromatographic behavior reports date use methodology larger complex proteins recently group generated focused libraries antibody fab fragment variants different combinations surface hydrophobicities electrostatic potentials demonstrated unique selectivities multimodal resins exploited separate fab variants work results linear salt gradient experiments fabs employed develop qsar models six chromatographic systems including multimodal capto mmc nuvia cprime two novel ligand prototypes hydrophobic interaction chromatography hic capto phenyl cation exchange cex sepharose resins models utilized newly developed local descriptors quantify changes around point mutations fab libraries well novel cluster descriptors recently introduced group subsequent rounds feature selection linearized machine learning algorithms used generate robust well validated models high training set correlations well suited predicting elution salt concentrations various systems developed models used predict retention deamidated fab isotype variants varying success results represent first successful utilization qsar prediction chromatographic behavior complex proteins fab fragments multimodal chromatographic systems framework presented employed facilitate process development purification biological products product related impurities silico screening resin alternatives biotechnol bioeng wiley periodicals inc
autoimmune gastritis often suspected hematologic findings rarely diagnosis made presence gastrointestinal symptoms aims cross sectional study assess large cohort patients affected autoimmune gastritis occurrence pattern gastrointestinal symptoms evaluate whether symptomatic patients characterized specific clinical features gastrointestinal symptoms consecutive autoimmune gastritis patients systematically assessed classified following rome iii criteria association symptoms anemia pattern positivity gastric autoantibodies helicobacter pylori infection concomitant autoimmune disease evaluated total patients female median age years range pernicious anemia iron deficiency anemia gastric autoantibodies autoimmune disorders present however patients complained gastrointestinal symptoms exclusively upper symptoms lower concomitant upper lower symptoms dyspepsia subtype postprandial distress syndrome represented present symptomatic patients univariate multivariate analyses showed age years absence smoking habit absence anemia independent factors associated dyspepsia autoimmune gastritis associated almost cases gastrointestinal symptoms particular dyspepsia dyspepsia strictly related younger age smoking absence anemia
aim study compare features two groups cocaine dependent patients treatment one morbid diagnosis antisocial personality disorder cross sectional design cocaine dependent patients attending drug unit distributed two groups patients without antisocial personality disorder results found sample diagnosed antisocial personality disorder relation socio demographic variables antisocial personality disorder patients less probability working studying multivariate analysis found significantly antisocial personality disorder patients opiates dependence sedative dependence cases show borderline personality disorder study highlights significant differences cocaine addicts without antisocial personality disorder differences good indicators complexity patients personality disorder better knowledge profile help improve design specific treatment programs
potential cardiac implantable electronic device leads interfere tricuspid valve function gained increasing recognition hemodynamic clinical consequences associated incremental morbidity death diagnosis treatment lead related distinct functional tricuspid regurgitation pose unique challenges pitfalls routine diagnostic imaging high level clinical suspicion must maintained avoid overlooking possibility worsening heart failure consequence mechanical interference leaflet mobility coaptation amenable lead extraction valve repair replacement future cardiac implantable electronic devices includes pacing perhaps defibrillation without lead traversing american college cardiology foundation
determine effect glucocorticoids gcs endothelial dysfunction traditional cardiovascular risk factors adjuvant induced arthritis aia rat model first signs aia high dose day intraperitoneally low dose day prednisolone administered weeks endothelial function studied aortic rings relaxed acetylcholine ach without inhibitors nitric oxide synthase nos cyclooxygenase cox arginase endothelium derived hyperpolarizing factor edhf superoxide anions degrees production aortic expression endothelial nos enos ser phospho enos cox arginase phox phox evaluated western blotting analysis arthritis scores blood pressure heart rate blood levels cytokines triglycerides cholesterol glucose measured reduced arthritis score significantly improved ach induced relaxation positive effect resulted increased nos activity edhf production decreased cox arginase activities degrees production functional effects relied upon increased phospho enos expression decreased cox arginase nicotinamide adenine dinucleotide phosphate nadph oxidase expression despite lack effect increased nos edhf regulated degrees pathways change arginase cox pathways increased triglycerides levels blood pressure significantly doses gcs decreased extent plasma interleukin beta tumour necrosis factor tnf alpha levels data demonstrated subchronic treatment prednisolone improved endothelial function aia via pleiotropic effects endothelial pathways effects occurred independently deleterious cardiometabolic effects impact prednisolone systemic inflammation
background erythropoiesis stimulating agents esas commonly used treatment anemia due chronic kidney disease ckd end stage renal disease esrd patients often lack understanding potential risks benefits esas despite government mandated education topic decision aids tools commonly used discuss important information health care settings address knowledge gap designed study evaluate effectiveness novel esa decision aid promoting informed shared decision making isdm patients providers related esa use ckd esrd related anemia methods using principles informed shared decision making theory designed piloted esa decision aid intended increase ckd esrd patient understanding potential risks benefits esas informed findings development esa decision aid modified finalized testing perform randomized clinical trial assess administration esa decision aid improves patient understanding risks benefits esa use compared control patients receiving standard care participants either ckd esrd receiving esas eligible participation primary outcome patients score patient anemia knowledge kidney disease pakkd survey assessed enrollment months secondary outcomes include decisional conflict related esas patient satisfaction provider communication discussion anemia risk communication patients kidney disease arc study assess effectiveness novel esa decision aid improve patient understanding esa use manage ckd esrd related anemia decision aid first resource targeted improve patient understanding anemia management kidney health context increasing options available anemia management serve important foundation evolve future optimize anemia related shared decision making
objective study bring policy changes respect managed aquifer recharge focusing infiltration ponds view relevant stakeholders may ease problem groundwater depletion context chennai city tamil nadu india groundwater needed drinking water security chennai overexploitation resulted depletion seawater intrusion current policies municipal state national level support recharge groundwater rainwater harvesting counter groundwater depletion however despite favorable policies legal framework administrative praxis support systematic approaches towards managed aquifer recharge periphery chennai present study confirms considering mandates governmental key actors survey preferences motives stakeholder representatives stakeholder groups interests groundwater issues lack common vision example conflicting interest stakeholders may hinder implementation certain types managed aquifer recharge methods overcome problem stakeholders support idea establish authority state licensing groundwater extraction overseeing managed aquifer recharge
higher education interdisciplinary gender studies centers deconstruct traditional androcentric positivist academic knowledge making possible apply gender perspective objects knowledge however suffer insufficient recognition weak institutionalization brazilian academia paper focuses trajectories gender studies centers affiliated north northeast gender studies feminist network redor founders analysis based documentary data biographical autobiographical narratives histories centers women intertwine personal institutional dimensions involvement feminist studies influenced personal professional lives many suffered prejudice discrimination researching gender practically continue activism within universities order sustain centers research supported cnpq capes grants
introduction hematological disorders account causes acute stroke systematized review presents updated information implications category heterogeneous diseases cause stroke areas covered relevant aspects relationship stroke hematological disorders reported high index suspicion needed young stroke patients patients recurrent stroke undetermined cause patients prior history venous thrombosis identify potential hematological disorder definitive etiology stroke expert commentary stroke presenting manifestation specific hematological disease may appear complication course hematological disorders important make correct diagnosis underlying hematological disorder order treat stroke patients promptly appropriately well establish optimal secondary prevention strategy recurrent vascular cerebral disease
despite continuing emphasis evaluation management clinical services adult interventional radiology practice peer reviewed literature addressing services potential economic benefits lacking pediatric practice measure effects expanding evaluation management services establishment dedicated pediatric interventional radiology outpatient clinic inpatient reporting system collected analyzed current procedural terminology cpt codes patients seen pediatric interventional radiology outpatient clinic november august also calculated number new patients seen clinic subsequent procedure procedural conversion rate comparison used historical data comprising pediatric patients seen general interventional radiology clinic years immediately prior inpatient reporting system implemented inpatient subsequent procedural services july september collected analyzed estimated revenue outpatient inpatient services using medicare physician fee schedule global non facility price surrogate following inception pediatric clinic number new outpatients month procedural conversion rate estimated revenue estimated procedural revenue new outpatients increased following implementation inpatient clinic reporting system consults subsequent hospital encounters per month procedural conversion rate growth observed meaningful metrics following expansion outpatient inpatient pediatric services
using technology computer aided design simulation investigated impact equivalent oxide thickness eot threshold voltage variation induced work function variation wfv multigate devices wfv induced vth variation multigate devices significantly vary dielectric constant gate dielectric material increases decreasingphysicaloxide thickness becomes thinner electric field tends locally concentrated causing large variation electrostatic potential channel slope ratio average grain size gate area rgg plot observed various oxide thicknesses confirmed alleviate wfv induced vth variation without significant performance degradation gate dielectric layer becomes thicker appropriately adopted higher engineering addition impact eot including interface layer wfv induced vth variation studied
carbamylation non enzymatic post translational modification induced upon exposure free amino groups urea derived cyanate leading irreversible changes protein charge structure function levels carbamylated proteins increase significantly chronic kidney disease carbamylated albumin considered important biomarker indicating mortality risk high plasma concentrations long half life make fibrinogen prime target carbamylation aggregation cross linking fibrin monomers rely lysine residues likely carbamylation impacts fibrinogen processing study investigated carbamylation levels fibrinogen kidney disease patients well impact carbamylation fibrinogen cleavage thrombin fibrin polymerisation cross linking vitro conjunction factors determine clot structure stability thus control biochemical mechanical properties analyses revealed significantly higher homocitrulline levels patient fibrinogen fibrinogen isolated control plasma vitro studies found although carbamylation affect thrombin cleavage per alters fibrin polymerisation kinetics impairs cross linking clot degradation addition carbamylated fibrin clots reduced fiber size porosity associated decreased mechanical stability using mass spectroscopy discovered terminally carbamylated fibrinopeptide generated process acted strong neutrophil chemoattractant potentially mediating recruitment inflammatory cells sites fibrin ogen turnover taken together carbamylation fibrinogen seems play role aberrant fibrin clot formation might involved haemostatic disorders associated chronic inflammatory diseases
background aim polymorphisms aryl hydrocarbon receptor nuclear translocator like arntl gene key component circadian clock manifests circadian rhythm abnormalities seasonal affective disorder sad associated disrupted circadian rhythms main objective study screen indian family sad arntl gene polymorphisms materials methods study members close knit family sad age sex matched controls caste prior history psychiatric illness age sex matched controls belonging different castes prior history psychiatric illness genotyped five different single nucleotide polymorphisms snps arntl gene taqman allele specific genotyping assay statistical analysis statistical significance assessed powerful quasi likelihood score test results family members carried risk alleles observed highly significant snp arntl gene allelic frequency conclusions polymorphisms arntl gene disrupt circadian rhythms causing sad genetic predisposition becomes deleterious presence adverse environment
attempt explain inconsistent findings overall weak relation empathy aggression focused role emotional empathy emotions concern compassion sympathy toward potential victim agentic goals desire dominant social interaction peers interplay mediation moderation prediction proactive aggression learned instrumental behavior adolescence data collected young dutch adolescents filled multiple questionnaires findings showed link lack empathic concern proactive aggression partly mediated moderated agentic goals moderation analyses showed predictive value lack empathic concern regard proactive aggression greater adolescents reported stronger desire dominant social situations peers addition findings supported assumption relation empathic concern reactive aggression hostile angry response perceived provocation mediated moderated agentic goals findings discussed terms implications future research wiley periodicals inc
damage detection methodology proposed integrating nonlinear recursive filter non contact computer vision based algorithm measure structural dynamic responses phase based optical flow algorithm inspired motion magnification technique used measure structural displacements unscented kalman filter used predict structural properties stiffness damping coefficients non contact displacement measurement methodology require intensive instrumentation process add additional mass structure may skew measurements measure signals compared traditional methods measurement methodology still needs improvement tool due higher noise level relative traditional accelerometer laser vibrometer measurements order detect structural damage using measured displacements video unscented kalman filter used remove noise displacement measurement simultaneously detect damage identifying current stiffness damping coefficient values given known mass used detect damage validate proposed damage detection method state space equations derived without external excitation input experimental tests carried experimental results show reasonable accurate predictions stiffness damping properties compared dynamic analysis calculations elsevier ltd rights reserved
assessment impact climate change depends quantitative changes precipitation also system characteristics changed enhanced study investigated effect building shared network rainwater harvesting system adaptation climate change scenarios performance rain barrel network three climate change scenarios three global circulation models gcm examined sample community composed four prospective users individual storage tested various forms shared connections importantly results show benefit shared rain barrels greatly increases climate change conditions compared historical rainfall data especially high reliabilities results indicate benefit rain barrel network increases future climate change scenarios whereas show apparent improvement low reliabilities however performance rain barrel network highly dependent location climate change scenarios contrast gcm considerably affect performance shared network results study highlight needs establish sharing networks rainwater harvesting systems climate change conditions would significantly increase benefit entire community elsevier rights reserved
derive john sclavounos equations describing motion fluid particle sea surface first principles using lagrangian hamiltonian formalisms applied motion frictionless particle constrained unsteady surface framework leads number new insights particle kinematics main result vorticity generated stress free surface vanishes wave crest horizontal particle velocity equals crest propagation speed kinematic criterion wave breaking holds largest crest symplectic two form associated hamiltonian dynamics reduces instantaneously associated motion particle free flight surface exist exploiting conservation hamiltonian function steady surfaces travelling waves show particle velocities remain bounded times ruling possibility finite time blowup solutions
present vector field approximation two dimensional vector fields preserves topology significantly reduces memory footprint approximation based segmentation flow within segmentation region approximated affine linear function implementation driven four aims approximation preserves original topology maximal approximation error user defined threshold regions number regions small possible point minimal approximation error generation optimal solution computationally infeasible discuss problem provide greedy strategy efficiently compute sensible segmentation considers four aims finally use region wise affine linear approximation compute simplified grid vector field
electrorheological fluid erf smart material transpose liquid like state solid like state action electric field along process physical properties material changed like apparent viscosity yield stress acoustic impendence paper means ultrasonic shear wave reflectometry method transformation laws resistive components reactive components complex dynamic shear impedance storage modulus loss modulus sound velocity supplied
paper present morphological electrical characteristics junction formed type films deposited type silicon wafer using hot wire chemical vapor deposition hwcvd tool describe fabrication process study influence diborane flow postprocess annealing improving junction characteristics morphological studies undertaken using atomic force microscopy show initial deposition suffered voids rather uniform film however improves significantly annealing treatment improvement morphology observed electrical characteristics estimated doubling rectification junction improving several orders magnitude fitting current voltage curves two diode model showed increasing diborane flow process helps reduce saturation current ideality factors increasing shunt resistance electrochemical capacitance voltage ecv quasi steady state photoconductance measurements used characterize deposited films solar cell device silicon epitaxy emitter modeled using industry standard modeling tools input parameters experimental data impact defects studied potential efficiency approaching shown feasible optimized device
context various processes including inflammation endothelial dysfunction implicated pathogenesis cardioembolic strokes objective review evidence investigate association immune inflammatory biomarkers strokes versus stroke subtypes methods systematically reviewed literature sources medline web based register http stroke biomarkers com reference lists quality assessment meta analysis selected articles results consistent association found reactive protein crp strokes compared stroke subtypes standardized mean difference conclusions findings confirm possible association selected inflammatory biomarkers stroke
many important network functions require online membership lookup large set addresses flow labels signatures paper studies difficult yet less investigated problem called multi set membership lookup involves multiple sometimes hundreds even thousands sets lookup determines whether element member sets also set belongs facilitate implementation multi set membership lookup die memory network processor line speed packet inspection existing work uses variants bloom filters encode set ids however thorough analysis mechanism performance prior art much surprise find bloom filters originally designed encoding binary membership information actually efficient encoding set ids paper takes different solution path separating membership encoding set storage two data structures called index filter set table respectively new placement strategy called uneven candidate entry distribution two level design index filter demonstrate analysis simulation compared best existing work new approach able achieve significant memory saving lookup accuracy requirement achieve significantly better lookup accuracy memory constraint
elliptic curve cryptography ecc widely used digital signature ensure secu rity communication important ecc processor support variety ecc standards compatible different security applications thus flexible proces sor support different standards algorithms desired paper efficient flexible dual field ecc processor using hardware software approach presented proposed processor support arbitrary elliptic curve elaborate modular arithmetic logic unit designed perform basic modular arithmetic opera tions achieve high efficiency based designed instruction set processor programmed perform various point operations based different algorithms demonstrate flexibility processor pointmultipli cation algorithm power analysis resistance adopted design implemented field programmable gate array platform also application specified inte grated circuit implemented cmos process processor takes bits ecc bits ecc finish one pointmultiplication compared related works merits ecc pro cessor high hardware efficiency flexibility
contaminants emerging concern cecs often poorly removed wastewater using conventional treatment technologies limited understanding fate treatment inappropriate sampling strategies lead inaccuracies estimating removals cecs study used fractionated approach accounts residence time distribution rtd treatment units investigate fate target cecs municipal wastewater treatment plant wwtp includes primary secondary tertiary treatment steps prior hydraulic calibration treatment unit performed wastewater sludge samples collected different locations along treatment train concentrations target cecs measured liquid chromatography mass spectrometry substantial aqueous removal occurred activated sludge treatment removals primary clarifier tertiary rotating biological contactors rbcs sand filtration mass balance calculations demonstrated bio degradation accounted removal primary clarifier activated sludge removal sorption primary secondary sludge minimal cecs analysis selected metabolites demonstrated negative removals obtained could explained transformations parent compound metabolites study contributes growing literature applying fractionated approach calculate removal different types cecs across wastewater treatment step additional level understanding fate cecs provided mass balance calculations primary secondary treatments elsevier rights reserved
direct numerical simulations used study interaction cavity backed circular orifice grazing laminar turbulent boundary layers incident sound waves flow conditions geometry representative single degree freedom acoustic liners applied inlet exhaust ducts aircraft engines experiments conducted nasa langley simulations identify fluid mechanics sound field state grazing boundary layer impact orifice flow suggest simple flow analogy enables scaling estimates scaling estimates simulations used develop reduced order models orifice flow time domain impedance model constructed liner found increase drag conditions studied amount increases incident sound pressure amplitude
aim study evaluate effectiveness tolerability doses paliperidone palmitate mgeq days patients severe schizophrenia clinical global impression severity scale cgi retention treatment month prospective observational study carried patients severe schizophrenia treated every days achieve clinical stabilization assessment included cgi disability assessment schedule camberwell assessment need medication adherence report scale laboratory tests weight side effects reasons discharge hospital admissions measured average dose mgeq days one discharge side effects weight prolactin levels decreased years cgi camberwell assessment need disability assessment schedule four areas decreased medication adherence report scale increased fewer hospital admissions retention treatment months tolerability mgeq days good useful improving treatment adherence severely ill patients helping way achieve clinical stabilization better social functioning patients clozapine candidates thus high doses could alternative copyright wolters kluwer health inc rights reserved
incidence bradykinin induced angioedema considerably lower histamine induced forms however true clinician knowledge condition bradykinin induced angioedemas include hereditary angioedema hae well acquired forms induced drugs antibody formation course oncologic disease drug induced forms affect almost exclusively head neck region thus important otorhinolaryngologist clear differentiation histamine induced angioedema connected allergy urticaria bradykinin induced angioedema essential selection specific treatment may lifesaving antihistamines cortisone derivatives relevant effect bradykinin induced angioedema whereas blood derived esterase inhibitor bradykinin receptor antagonists represent effective therapeutic options acute prophylactic treatment
cerebral cavernous angioma cavernoma benign vascular malformation usually asymptomatic infrequent often discovery incidental called incidentaloma however lesions symptomatic causing headaches epilepsy cerebral hemorrhage neurological signs depending brain area involved frontal localization responsible psychiatric disorders particularly prefrontal region leading prefrontal syndrome condition common frontal lobe tumors psychopathological syndrome depression type pseudodepression syndrome maniac type pseudomaniac syndrome surgical treatment lesions like may always possible due location eloquent areas study describe unusual association migraine like headache epilepsy frontal lobe pseudodepression late onset syndrome patient considered case interesting mainly rarity headache migraine features late onset pseudodepression syndrome pathophysiology underlying migraine like headache concerning late onset pseudodepression frontal lobe syndrome seems unclear case leads hypotheses mechanisms responsible headache syndromes psychopathological disorders specific case caused cerebral frontal lobe lesion
backgroundmobile applications apps could support diabetes management dietary weight blood glucose self monitoring well promoting behaviour change present study aimed evaluate diabetes apps content functions behaviour change techniques bcts methodsdiabetes self management apps android smartphones searched google play store ten apps following search terms included diabetes diabetes type diabetes type gestational diabetes apps evaluated scored according number functions bcts price user rating resultsthe mean number functions possible maximum furthermore mean number bcts possible maximum apps optimum bct significantly functions confidence interval apps significantly bcts apps without additionally apps optimum bct also cost apps adjusted models highly rated apps average functions lower rated apps conclusionsdiabetes apps include functions bcts compared maximum score possible apps optimum bcts could indicate higher quality app developers consider including specific functions bcts diabetes apps make helpful research needed understand components effective app people diabetes
paper aims develop evaluate information assurance security learning materials hardware firmware attacks undergraduate education topics include firmware worms application programming interface operating systems computing devices equipped firmware performs basic hardware testing loads operating systems according hardware rooted security guidelines following fundamental security primitives required roots trust application programming interface api platform policy enforcement engine believe important verify primitives integrity hands experiments educate next generation computer experts learning material implemented evaluated undergraduate computer architecture course using intel chipsec validate bios terms known vulnerabilities
process constructing scale prosocial behavior adults presented reliability dimensionality tests conducted classical test theory perspective items assessed means expect judge method items shortlisted administered reduced groups students psychology university buenos aires took part test internal consistency analysis shows satisfactory ratio alpha glb dimensionality analysis presents four factor structure factors empathic behavior altruism help share numerous behaviors connected emotional reinforcement support posted high average items typically associated philanthropist behavior volunteer work clothes food money donations highly ultraistic practices yielded low scores
present general computation model inspired notion information hiding software engineering model form game call quiz game allows uniform way prove exponential lower bounds several complexity problems elsevier inc rights reserved
signal flow graph sfg nonlinear modeling approach well known modeling converters powerful analysis tool higher order converter systems modeling several specific fourth order converter circuits reported using conventional state space averaging particular emphasis given far arrive large small signal steady state models generalized one paper gives generalized sfg model fourth order converter topology useful generating different types fourth order converter circuits unified models shown deduction large steady state models unified sfgs easy straightforward possible fourth order converter circuits generalized topology identified analysis converter circuits given illustration proposed modeling method large signal models developed different topology configurations programmed simulink simulator responses supply load disturbances obtained experimental observations provided validate proposed modeling method
nicotin replacement therapy nrt preferred first option smoking cessation treatment many years nrt reduces desire smoke withdrawal symptoms nicotine gum addiction may rarely develop nrt study present case became addicted nicotine gum years admitted smoking cessation polyclinic treated bupropion aim case study highlight bupropion also effective option treat nicotine gum addiction rarely seen occurrence
students begin university studies generally characteristics lack habits skills often obstacle development different field teaching learning patterns two elements contribute positively process motivation integration learned different subjects article describe strategy developed first course computer programming based solving engineering problems students work problem throughout year project organized stages ultimate goal develop computer application must work searching extracurricular information resignifying learning different subjects building tools useful students
background mild traumatic brain injury mtbi represents treated brain injuries considerable proportion mtbi patients experience post concussion symptoms prolonged period mtbi symptoms diagnosed persistent post concussion syndrome ppcs ppcs defined range physical cognitive emotional symptoms however memory executive dysfunction seems one debilitating symptoms recently non invasive brain stimulation studied potential treatment method traumatic brain injury tbi patients therefore primary goal verify effects transcranial direct current stimulation tdcs patients ppcs demonstrate cognitive deficits long term episodic memory working memory executive function following mtbi methods design randomized crossover trial patients history mtbi cognitive deficits memory executive function thirty adult patients randomized crossover manner receive three weekly sessions anodal tdcs left dorsolateral prefrontal cortex left temporal cortex sham stimulation performed day intervals washout period clinical diagnosis ppcs determined using rivermead post concussion symptoms questionnaire patients meet inclusion criteria assessed neuropsychological evaluation new battery computerized neuropsychological tests performed immediately stimulation statistical analysis performed determine trends cognitive improvement discussion paucity studies regarding use tdcs tbi patients although recent results showed controversial data regarding effects tdcs patients address specifically patients ppcs mtbi brain abnormalities scan subarachnoid hemorrhage moreover due missing information literature regarding best brain region studied evaluate two different regions find immediate effects tdcs memory executive dysfunction
aim study reduce level homocysteine hcy high methionine dietary supplementation folic acid evaluate changes lipid parameters blood serum experimental rats animals randomly divided seven groups male fed seven different diets days rodents fed semi synthetic diet group supplemented methionine diet group whereas groups iii vii fed semi synthetic diet supplemented methionine diet folic acid diet respectively contents homocysteine total cholesterol level hdl fraction triacylglycerols assessed enzymatically rats serum addition ldl vldl cholesterol content calculated folic acid content diet found highly negatively correlated homocysteine content negatively correlated triacylglycerols content serum rats serum rats fed methionine diet highest folic acid supplementation folic acid diet homocysteine triglyceride contents significantly lower compared animals fed types experimental diets
trait social cognitive perspectives considered disparate approaches understanding personality suggest integrative view three elements derived social cognitive perspective situations behaviors explanations sbes form basis personality traits study demonstrated strong associations traits sbes across big five dimensions studies tested discriminative validity internal structure unique contributions individual components sbes studies demonstrated strong associations traits sbes generalize different cultures present work suggests sbes may universal folk psychological mechanism underlying personality traits
problem improving reliability creation fault tolerant systems one important modern technology engineering actually complexity technical systems increasing thus requirements reliability indices constantly increasing especially correct assessment design stage well operating conditions important order improve reliability modern trends electrification various types vehicles set similar tasks developers engineers electric propulsion systems considering electric propulsion systems safety critical strict requirements imposed reliability fault tolerance component units traction motor power electronics electric power source control unit paper presents systematic method estimation fault tolerance multi phase permanent magnet synchronous motors based multi level markov model lifecycles multi state system impact fault tolerance degree regarding number phases permanent magnet synchronous motors investigated practical application proposed technique multi phase traction motor results presented finally results study allowing fault tolerance assessment choice appropriate traction electric motor design considering reliability fault tolerance discussed
study considers employees tenacity might enhance propensity engage knowledge exchange organizational peers well positive tenacity knowledge exchange relationship invigorated two types role conflict within work work family using data large mexican organization logistics sector study shows tenacity increases knowledge exchange effect stronger higher levels within work work family role conflict invigorating role within work role conflict particularly salient work family role conflict high findings inform organizations application personal energy knowledge enhancing activities particularly useful employees encounter severe workplace adversity conflicting role demands
beaver dams significant impacts hydrology temperature biogeochemical processes geomorphology streams riparian areas also used viable tool restoring impaired riverine systems dynamic nature beaver dams influences vary difficult quantify begin understanding impacts beaver dams mountain streams developed hydraulic models beaver impacted reach includes eight dams non impacted reach compare hydraulic responses channel depth width velocity distributions also compared observations substrate size distributions different geomorphic habitat units within reach results models indicated shifts channel hydraulics statistically significant increases depths widths well decrease flow velocities beaver impacted reach hydraulic adjustments result beaver dams consistent observed changes increased variability spatial heterogeneity sediment size distributions application three different modelling approaches found relatively low number beaver dams would result significant changes channel hydraulics results provide preliminary information regarding number dams per unit stream length required begin meeting various restoration goals
analog clock generator built complementary logic cells utbb fdsoi delivers robust symmetrical clocks required control high performance differential switched capacitor circuits using back gate feedback sizing respecting static dynamic symmetry proposed solution tolerant process inherent variations deep nanometer cmos processes
blood velocity measurements important physiological science clinical diagnosis doppler ultrasound commonly used method measure one velocity component ultrasound imaging velocimetry uiv promising technique capable measuring two velocity components however limit maximum velocity measured conventional hardware results way images acquired sweeping ultrasound beam across field view interleaved uiv extension uiv two image frames acquired concurrently allowing effective interframe separation time reduced therefore increasing maximum velocity measured sweeping ultrasound beam across image results systematic error must corrected work derived implemented new velocity correction method accounts acceleration scatterers first time assessed performance interleaved uiv measuring pulsatile arterial velocities measuring flows phantoms vivo comparing results spectral doppler ultrasound transit time flow probe data velocity flow rate phantom agreed within peak velocity peak flow respectively vivo velocity difference peak velocity maximum velocity measured highest velocity reported uiv allow flows diseased arteries investigated potential increase diagnostic accuracy enable new vascular research
background objectives study determine common injuries gaelic football hurling quantify contributory factors hypothesis hypothesis tested ankle sprains common injury gaelic football hurling incidence linked physical characteristics players methods experimental design prospective study four pears subjects eighty male players gaelic football hurling aged sears measures injuries sustained four year period physical fitness tests examination start study included assessment anthropometric variables lower limb proprioception lung function six aspects flexibility aspects posture body mechanics results significant sports injuries included strains sprains ankle sprains left ankle right ankle sprains represented recurrence injury particular individual subjects ankles involved suggests recurrence primarily due previous injury intrinsic factors subjects predispose ankle sprain subjects sustained ankle sprains greater height lower body mass index higher incidence posture defects ankle knee clinical defects higher incidence defective lower limb proprioception conclusions ankle sprains common injury incidence linked five intrinsic factors listed
analysed extent ecological damage gully inter gully erosion sub catchment situated drylands mmyr winter rainfall area south africa small stock farming rangeland main source income applied low cost measures revegetate bare sites inter gully erosion stabilised gully erosion loosening soil surfaces applying geotextile constructing check dams reverse gully erosion compared vegetation cover silt accumulation penetration resistance soil upslope check dams situation downslope check dams untreated gullies controls treated bare patches compared penetration resistance vegetation cover untreated controls two years implementation restoration measures resulted increased soil depth vegetation cover upslope check dams increased vegetation cover treated bare patches calculated net present value restoration measures based financial benefit landowner realistically expect current economic governance conditions payment additional livestock sequestration current rates return livestock production carbon sequestration year period rehabilitation sort financially feasible private landowners either current payment carbon sequestration would increased magnitude restoration measures would funded public private sector make financially viable landowners copyright john wiley sons ltd
hiv pandemic continues impose enormous morbidity mortality economic burdens across globe simultaneously innovations antiretroviral therapy diagnostic approaches vaccine development providing novel tools treatment prevention prophylaxis developed mathematical model evaluate added benefit hiv vaccine context goals increase rates diagnosis treatment viral suppression countries status quo interventions predict median million first third quartiles incident cases globally achieving joint united nations program hiv aids target estimated avert million new infections additional million reduction projected introduction efficacy vaccine gradually scaled coverage added benefit prevention vaccination motivates imminent ongoing clinical trials viable candidates realize goal hiv control
using bell polynomials method symbolic computation study integrability kdv equation develop work new results regarding integrability concept show newly developed bilinear representation bilinear backlund transformation different reported literature moreover firstly present infinite conservation laws conserved densities fluxes given explicit recursion formulas copyright john wiley sons ltd
background association migraine incidence ischemic stroke varies different subgroups patients aimed clarify association using population based database method nationwide cohort study conducted using data taiwan national health insurance research database two cohorts extracted neurologist diagnosed migraine cohort non headache propensity score matched comparison cohort participants enrolled study followed end death occurrence ischemic stroke adjusted hazard ratios ahrs confidence intervals cis calculated cox proportional hazards model compare group risks results cohorts followed mean period years total migraine patients person years matched comparison individuals person years developed ischemic stroke research period compared comparison cohort patients migraine increased risk ischemic stroke ahr subgroup analysis age sex revealed highest risk women aged years ahr especially among migraine aura ahr trend increased stroke risk observed men aged years ahr conclusion migraine associated increased risk ischemic stroke especially younger age years women migraine aura trend toward ischemic stroke younger men merits exploration
limited consideration empirical studies treatment resistant bipolar disorder trbd exploratory study designed identify factors contributing trbd patients bipolar disorder patients categorized low medium high levels treatment resistance based total number psychiatric medications received second analysis number mood stabilizer medications received study identified number factors associated trbd female older older age illness onset higher incidences family depression less likelihood paid employment higher number lifetime stressors medical conditions comorbid anxiety disorders different personality temperament profile regular use benzodiazepines factors associated trbd defined number mood stabilizers trialed potential explanations findings explored
many individuals meet develop friendships online result people must form impressions online acquaintances based person online representation investigate personality inferences intentions befriend based solely simple avatars customized cartoon representations self data show traits easily inferred avatars others avatars communicate accurate distinctive information regarding personality individuals certain personality traits create avatars likely perceived accurately also found agreeable normative individuals created avatars elicited desire friendship others implying impression given one digital avatars may social consequences
examined culturally relevant gender differences attachment dimensions dyadic associations relationship functioning using large sample considering attachment avoidance culturally incongruent turkish culture exist sharp gender role difference marriage anticipated avoidance women anxiety men would strong dyadic predictors satisfaction conflict among married couples dyadic analyses revealed attachment dimensions incongruent cultural characteristics gender roles predicted marital conflict satisfaction avoidance anxiety actor partner effects marital satisfaction attachment anxiety husbands wives linked marital conflict attachment avoidance seems primary risk factor satisfaction attachment anxiety conflict turkish cultural context
background estimated new cases endometrial cancer diagnosed women die united states previous studies suggested high levels coffee consumption may associated reduced risk endometrial cancer among women ages although caffeine major ingredient coffee one study stated inverse association differ according caffeine content regular coffee decaffeinated coffee however specific measurement caffeine intake clear previous study study tries investigate endometrial cancer risk relation caffeine intake coffee consumption methods national health nutrition examination survey nhanes surveys used study total postmenopausal women valid cancer status included study chi square tests tests used examine differences proportions multiple logistic regression models used determine whether association caffeine intake endometrial cancer adjustment various potential confounding variables weighting supplied nhanes data results among women study diagnosed endometrial cancer multivariate adjustment compared women caffeine intake significant increase endometrial cancer found levels caffeine intake day non taken coffee consumption day non taken results also showed black women women using birth control pills less likely get endometrial cancer women excessively obese significantly higher risk getting endometrial cancer conclusions findings suggested caffeine intake associated endometrial cancer compared caffeine intake level coffee consumption caffeine intake risk factors endometrial cancer black women lower risk endometrial cancer history birth control pill use protected factor excess obesity risk factor endometrial cancer
aim study link concentrations particulate matter aerodynamic diameter associated heavy metals occurrence wheezing hospitalizations due wheezing children live near metallurgical plants targoviste city romania group children high levels immunoglobulin ige eosinophils well frequent wheezing episodes geolocated digital thematic maps monitoring campaigns medical assessments performed two consecutive years multiannual average concentrations ranged maximum value significant correlations observed locations children respiratory issues multiannual average maximum main marker elements emissions steel production metal working facilities targoviste area results support hypothesis increased levels directly influence wheezing symptom asthma attacks analyzed group ige eosinophils wheezing episodes may considered key indicators evaluate adverse effects air pollution children health
public engagement essential procedural substantive sustainability environmental assessment public hearings present lowest barrier entry public participation forums face competing political pressures conducting appropriate public engagement within expeditious process repositories public hearing testimony provide source primary data examining public engagement issues environmental assessments however time resources required may prohibitive conducting kind depth qualitative analyses commonly used automated content analysis aca techniques provide rapid replicable inductive systematic way examine public hearing transcripts consisting critical development application computer programming scripts synthesize evidence extensive document sets case illustration demonstrates potential utility aca based examination two public hearings prairie creek nico conducted mackenzie valley northwest territories canada interpretation findings provides evaluation aca methods situates potential inform environmental assessment research practice across jurisdictions
laboratory experiments conducted large scale meandering compound channel investigate flow patterns apex cross sections equation curvilinear ordinates derived momentum equation flow continuity equation equation two shear stress terms ignored due negligible contributions simple expressions obtained several groups experimental data published literature used verify model comparison experimental predictive results indicates proposed method capable accurately forecasting stage discharge meandering compound channels finally simple analytical solution model velocity parameter discussed
mgfeo feo composites nanostructures synthesized different wet chemical methods precipitation reflux hydrothermal method xrd confirmed formation composite mgfeo feo phase precipitation reflux methods single mgfeo phase hydrothermal method well crystalline nature ftir study shifting adsorption bands metal oxygen bond corresponding vibration tetrahedral octahedral complexes mgfeo feo composites observed single mgfeo phase fesem images observed mgfeo feo nanocomposites prepared precipitation method contains smooth particles average diameters around mgfeo feo nanocomposites prepared reflux method contains uniform microspheres flower like hierarchical nanostructures thickness around mgfeo nanomaterials synthesized hydrothermal method contains irregular spherical nanoparticles diameter around prepared nanomaterials used photocatalysts degrade methylene blue dye aqueous media solar light irradiation mgfe ofeo nanocomposite prepared precipitation method regarded superb photocatalyst photocatalyst performed degradation methylene blue dye solution within mins irradiation time elsevier rights reserved
encounters across difference city spaces marked diverse migration trajectories cultural differences racialized hierarchies captured attention urban scholars concerned challenge living difference promise multicultural conviviality inhere super diversity many cities expanding approaches focus analyzing conditions good meaningful encounter reduce prejudice promote intercultural understanding paper brings interviews queer asian men sydney australia dialogue sara ahmed revaluation bad encounter shows research encounters productively engage negative encounters become meaningful political occasions right focusing problem sexual racism emerges accounts shared participants paper highlights dating sex important moments aesthetic orderings race gender sexuality shape unevenly shared spaces citizenship urban life
new operational amplifier cell high voltage current sensing applications presented paper proposed structure employs fully low voltage input stage capable tracking input common modes cms ranging gnd rail supply rail furthermore solution ensuring linearity amplifier entire operating voltages discussed proposed circuit implemented typical cmos bcd technology performances confirmed simulations silicon measurements
background adverse childhood experiences aces including child abuse household problems domestic violence increase risks poor health mental well adulthood factors access trusted adult child may impart resilience developing negative outcomes much childhood adversity mitigated resilience poorly quantified test access trusted adult childhood associated reduced impacts aces adoption health harming behaviours lower mental well adults methods cross sectional face face household surveys aged years february september examining aces suffered always available adult aaa support someone trust childhood current diet smoking alcohol consumption mental well undertaken four regions sampling used stratified random probability methods analyses used chi squared binary multinomial logistic regression results adult prevalence poor diet daily smoking heavier alcohol consumption increased ace count decreased aaa support childhood prevalence two behaviours increased aces aaa support affluent quintile residence aces lacking aaa support deprived quintile however increase reduced aaa support aces deprived quintile lower mental well cls times likely aces aaa support someone trust childhood ace aaa support increasing cls times likely aces without aaa support childhood multiple health harming behaviours combined lower mental well rose dramatically ace count lack aaa support childhood adjusted odds ratio cls aces without aaa support aces aaa support conclusions adverse childhood experiences negatively impact mental physical health across life course impacts may substantively mitigated always support adult trust childhood developing resilience children well reducing childhood adversity critical low mental well health harming behaviours combined contribution non communicable disease reduced
evaluated brain volume rate atrophy japanese patients multiple sclerosis mean brain volume smaller rate atrophy appeared rapid patients normal subjects brain atrophy seemed exist early stage prominent grey matter patients progressive showed severer atrophy show existence pathological brain atrophy japanese patients first time although rate atrophy may much slower caucasian patients elsevier rights reserved
background objectives although humans developed abundant strategies regulate negative emotions times distress frequently turn significant others seek comfort present study use novel performance based paradigm evaluate effectiveness interaction methods forty seven couples long term relationship volunteered participate study couple two partners randomly assigned either target regulator target viewed pictures negative valance response picture instructed choose apply regulatory strategy intrapersonal emotion regulation apply regulatory strategy chosen partner regulator interpersonal emotion regulation results found outside perspective regulator helped reducing distress effectively intrapersonal emotion regulation moreover cognitive emotional empathy regulator predicted added value interpersonal emotion regulation specifically regulators better ability understand partners point view selected regulatory strategies reduced levels distress effectively limitations present study examined possible effects depression anxiety ability identify describe feelings larger sample needed order optimally address potential moderating effect conclusions results illuminate value non professional interventions importance cognitive empathy reducing distress study significant clinical implications providing simple behavioral tool used decrease prevent psychopathology elsevier ltd rights reserved
paper approach optimization magnetic design permanent magnet linear generator exploitation energy contained sea waves presented approach consists two step procedure first one takes account stochastic features sea wave motion describe working condition machine motion adopting lumped parameter model step objective function energy production second step optimizes generator using results obtained first step constraints must fulfilled design based finite element method fem analysis furthermore approach applied design build linear generator experimental tests carried built linear generator presented
cancer related fatigue crf distressing persistent subjective sense physical emotional cognitive tiredness exhaustion related cancer cancer treatment proportional recent activity interferes usual functioning exerts deleterious effects many aspects body including physical social cognitive vocational functioning makes patients relatives feel emotional spiritual distress nevertheless still way diagnosis treatment based national comprehensive cancer network nccn clinical guidelines oncology crf version standards care crf assessment management standards evaluation treatment interventions patients active treatment critically interpreted article
social knowledge beyond one direct relationships key successfully manoeuvring social world individuals gather information quality social relationships group companions termed triadic awareness evidence use triadic awareness natural contexts limited mainly conflict management investigated triadic awareness wild barbary macaques macaca sylvanus context bridging interactions defined male infant male interactions whereby male initiator holder presents infant another male receiver non holder order initiate affiliative interaction male analyses based focal observations ten infants one wild social group morocco supported hypothesis males use knowledge relationship infants adult males choosing male partner bridging interactions specifically number bridging interactions among holder infant receiver triads positively affected strength infant receiver relationship two males available bridging partners male likely chosen receiver stronger social relationship infant relative available male demonstrates non human primates establish triadic awareness temporary infant male relationships use naturally occurring affiliative context results contribute discussion mechanism underlying acquisition triadic awareness benefits usage lend support hypotheses linking social complexity evolution complex cognition
aiming efficiently aware network security situation proposed framework network security situation awareness base cloud model network security situation elements core modified cloud model novel concept situation cloud act theoretical foundation transition qualitative quantitative representation situation elements finally experimental results showed two kind representations directly summarize security condition network well precisely recognize changes situation elements
skin bleaching practices using skin creams soaps achieve lighter skin tone common throughout world triggered cosmetic reasons oftentimes deep historical economic sociocultural psychosocial roots exposure chemicals bleaching products notably mercury hydroquinone steroids associated variety adverse health effects poisoning exogenous ochronosis new york city nyc skin care product use identified important route exposure especially among caribbean born blacks dominicans however surprisingly sparse information available epidemiology health impacts skin bleaching practices among populations highlight dearth large scale comprehensive community based clinical translational research area especially limited skin bleaching related research among non white populations offer five new research directions including investigating known studied health consequences among populations skin bleach practice newly emerging alarming rate using innovative laboratory statistical methods call conducting methodologically rigorous multidisciplinary culturally sensitive research order provide insights root epidemiological status practice provide evidence exposure outcome associations ultimate goal developing potential intervention strategies reduce health burdens skin bleaching practice
physically based multispectral image simulation consists sensor system modeling bottom atmosphere boa image generation top atmosphere toa image calculation toa radiance images usually generated using lookup table lut computational efficiency calculated means atmospheric radiative transfer codes different combination input variables including viewing zenith solar zenith relative azimuth angles visibility columnar water vapor ground elevation paper new strategy proposed toa radiance image simulation transmitted surface radiance atmospheric radiance toa calculated respectively improve accuracy well efficiency transmitted surface radiance image obtained pixel pixel calculation boa radiance path transmittance calculating atmospheric radiance toa two luts built emitted scattered radiance atmospheric layer respectively effects visibility columnar water vapor atmospheric radiance characterized means equivalent path transmittance related scene geometry well thickness atmospheric layer way new scene simulated except three variables viewing solar zenith angles atmospheric layer number parameters set constants building luts enabling combinations input variables without adding excessive computational burden multispectral images different bands moderate spatial resolution simulated compared moderate resolution imaging spectroradiometer modis images demonstrate accuracy usefulness proposed strategy
death neonate devastating involved year critically ill neonates present emergency departments across united states infants require acute medical interventions goal stabilization despite efforts hundreds infants die every year emergency departments across united states emergency care providers unaccustomed providing neonatal end life care may feel unsure best care families resuscitative measures neonates die literature suggest increased knowledge advance preparation calm fears providers caring patients tragic situations aim provide article broad overview variety topics related neonatal death bereavement care
review paper explores attempts made numerous authors field material selection ample amounts works carried field materials engineering data mining approaches literature revealed much work explored classification advanced composite materials using machine learning approaches
characteristic bodily composition physical exercise seem associated perception body image non probabilistic sample users gyms city armenia colombia genders years age mage studied relationship physical exercise non experimental association study model silhouettes applied also anthropometric measurement taken including fat percentage according faulkners equation frequency length physical information measure self report results disclose measures weight height body mass index body fat percentage significantly correlated perception satisfaction physical exercise yield significant correlations categories perception satisfaction gender differences described women significantly dissatisfied results make clear modulatory role exercise relationship objective measures perception
conclusion elevated motion sickness susceptibility mss meniere disease likely consequence onset migraine per objectives pathologies vestibular system influence mss bilateral vestibular deficits lower mss vestibular neuritis benign paroxysmal positional vertigo little overall effect whereas vestibular migraine elevates mss however less known mss condition many patients experience vestibular loss migraine symptoms methods authors conducted online survey posed diagnostic disease questions addressing frequency headaches migraines visual display dizziness vdd syncope social life work impact dizziness swid motion sickness susceptibility mssq two groups diagnosed individuals hearing loss non individuals control group results group showed significantly elevated mss headache migraine increased vdd higher swid scores increased syncope mss higher controls development childhood although elevated compared controls mss lower migraine patients past data multivariate analysis revealed vdd swid mss adulthood strongest predictors headache migraine
paper presents description technical characteristics autonomous hydroacoustic station developed pacific oceanological institute far eastern branch russian academy sciences toi dvo ran stationary measurements variations acoustic pressure frequency range shelf bottom organize real time monitoring parameters seismic survey impulse signals industrial acoustic noise station additionally equipped digital uhf radio telemetry channel acoustic data measured frequency band transmitted channel shore post well via iridium satellite radio telemetry channel controls operation uhf radio transmitter transmits results special analysis acoustic data obtained subsequent min time intervals
socio motor improvisation defined creative action two people without script anticipated preparation evaluated two main parameters movement synchronization movement richness experts art dance theater music known exhibit higher synchronization perform richer movements interpersonal improvisation competences evolve time largely unknown present study investigated whether performing synchronized richer movements time promote acquisition improvisation pairs novice participants instructed play improvisation mirror game three different sessions sessions performed unintended interpersonal coordination task synchronization richness manipulated resulting four different groups dyads results demonstrate synchronization improvisation improved groups whereas movement richness enhanced dyads performed synchronized movements unintended coordination tasks findings suggest movement synchrony contributes movement richness acquisition socio motor improvisation mirror game elsevier rights reserved
memristor nano device exhibits unique pinched hysteresis loop switching mechanism ability remember last state interesting memristor characteristics encourage researchers understand new device develop potential applications problem memristor yet available current market due cost technical difficulties fabrication nanoscale device thus way develop model memristor paper spice memristor models selected behaviors compared physical memristor verify model similarity actual device next new approach cmos memristor application proposed interfacing circuit spice memristor model cmos circuit presented interfacing circuit composed write circuit program memristor resistance read circuit read memristor current using operational amplifier current mirror interfacing circuit important incorporate memristor cmos cmos memristor application studies
several genes risk factors associated parkinson disease although many genetic markers belong common pathway unifying pathogenetic mechanism yet found also missing heritability analyses estimated part genetic influence contributing found carried whole exome sequencing wes finnish patients earlyonset also reanalyzed previous data genome wide association studies gwas cohort variants cel gene locus associated gwas wes analysis exome wide gene based association tests also identified mphosph tasr serpina genes discovery data set mphosph estimated odds ratio variant serpina identified several candidate genes investigation required determine role genes elsevier inc rights reserved
successive freeze thaw cycle widely used empirical approach shorten experimental period since could accelerate frozen dough deterioration compared frozen storage order compare effect cycle deterioration procedure chemical leavened steamed bread dough kinetic studies bread quality indices performed relationships bread quality dough components established results showed degradation steamed bread loaf volume firmness followed first order kinetics zero order kinetics respectively glutenin macropolymers gmp depolymerization dough weight loss occurred steadily throughout significant enhancement damaged starch crystallinity observed later period cycle multiple regression study led conclusion dough weight loss contributed reduced bread loaf volume whereas gmp depolymerization dominated condition elsevier ltd rights reserved
parameterized string string generalization traditional string two alphabets constant alphabet parameter alphabet parameterized match pmatch exists two strings constants match exactly exists bijection parameter symbols historically strings leveraged source code cloning plagiarism detection biological sequence structural similarity work identify connection match music one several applications motivate study holes strings prefix array based data structures strings first introduce parameterized prefix array ppa pstrings succinct representation compact parameterized prefix array cppa show interesting construction cppa via parameterized longest previous factor plpf recently proposed array connections various pattern matching data structures factorization next introduce parameterized string holes string needed address special form indeterminate pattern matching pstrings show construct compact prefix array strings finally discuss applications data structures elsevier rights reserved
european brown hare lepus europaeus species superconception whereby maternal reproductive tract hosts two sets conceptuses different developmental stages embryonic development hare yet described understand mechanism superconception studied oviduct transport implantation stages embryo flushing live high resolution ultrasound ultrasound data implantation stages correlated histology oviduct mucin coat deposited zona pellucida blastocysts enter uterine horns day day later rabbit directly expand approximately threefold spacing accompanied peristaltic movement endometrium mucin coat disappears conceptuses attach yolk sac expands blastocoel syncytial knobs invade antimesometrial endometrium maternal blood lacunae appear mesometrial endometrial folds subsequently invaded syncytiotrophoblast haemochorial chorioal lantoic placenta forms yolk sac cavity gradually replaced allantois finally exocoel different reproductive strategies precocial hare altricial rabbit discussed assume lagomorph specific mucin coat hare specific delay oviduct uterine transition prerequisites superconception
total patients diagnosed structured clinical interview dsm dissociative disorders revised dissociative identity disorder patients diagnosed structured interview dsm personality borderline personality disorder bpd groups administered multidimensional inventory dissociation mid patients significantly higher mid scores bpd patients different distributions mid scores different mid subscale profiles ranges mid scores core mid symptoms exhibited ranges mid scores patients presence alters identity confusion memory problems bpd patients flashbacks identity confusion memory problems ostensibly similar considered mostly produced different underlying processes multiple regression analyses showed core mid symptoms patients different predictors core mid symptoms bpd patients alter identities seemed generate dissociative phenomena patients whereas highest scoring bpd patients mid seemed manifest alter driven dissociative experiences bpd dissociative experiences appeared due mechanisms bpd specific stress driven rapid shifts self state nondefensive disruptions framework perceptual organization without accompanying bpd specific dissociation like disintegration affective neurocognitive functioning defensive distancing detachment distress simple depersonalization allen console lewis severe absorptive detachment
cerebrospinal fluid csf biomarkers reflect different aspects pathophysiology relapsing remitting multiple sclerosis rrms understanding impact different disease modifying therapies csf biomarker profile may increase implementation clinical practice appropriateness monitoring treatment efficacy study investigated influence first line interferon beta second line natalizumab therapies seven csf biomarkers rrms correlation clinical radiological outcomes included rrms patients healthy controls concentrations motif chemokine cxcl motif chemokine ligand ccl chitinase like protein chil glial fibrillary acidic protein neurofilament light protein nfl neurogranin determined elisa chitotriosidase chit analyzed spectrofluorometry rrms patients higher levels nfl cxcl chil chit controls subgroup analysis revealed higher nfl cxcl chit levels patients treated first line therapy compared second line therapy respectively nfl chit levels correlated relapse status nfl cxcl levels correlated formation new magnetic resonance imaging lesions furthermore found association inflammatory degenerative biomarkers results indicate csf levels nfl cxcl chil chit correlate clinical radiological disease activity providing additional dimensions assessment treatment efficacy
childhood trauma associated long term effects prefrontal limbic grey matter literature search conducted identify structural magnetic resonance imaging studies adults history childhood trauma performed three meta analyses hedges effect sizes calculated study providing hippocampal amygdala volumes trauma non trauma groups seed based differential mapping utilised synthesise whole brain voxel based morphometry vbm studies total articles hippocampus amygdala whole brain vbm included meta analyses trauma cohorts exhibited smaller hippocampus amygdala volumes bilaterally robust findings whole brain vbm meta analysis reduced grey matter right dorsolateral prefrontal cortex right hippocampus amongst adults history childhood trauma subgroup analyses meta regressions showed results moderated age gender cohort psychiatric health study definition childhood trauma provide evidence abnormal grey matter prefrontal limbic brain regions adults history childhood maltreatment elsevier ltd rights reserved
needle valve response input signal controlled apart dynamics driving mechanical actuator interaction fluidic mechanic aspects despite long history ubiquitous use needle valves aerodynamics never really systematically investigated recent uses extreme conditions new field additive manufacturing put great relevance accumulating aerodynamic research data third part trilogy presents results pressure measurements internal walls configurations characterised rounded needle tip entrance exit channel elsevier rights reserved
paper novel active block analog signal processing presented namely current controlled current differential current conveyor cccdcc multi terminal block features well known ccii second generation current conveyor cccdta current controlled current differencing tranconductance amplifier simplify realization current mode analog filters suitable signal processing proposed block applications simulated cmos process supply voltages results obtained hspice high detailed transistor library
parallelization applied neutron calculations performed heterogeneous method graphics processing unit parallel algorithm modified trec code described efficiency parallel algorithm evaluated
hereditary angioedema hae accompanied overproduction bradykinin primary mediator swelling although many proteins may involved regulating wide spectrum hae symptoms studies focused inh fxii first time next generation sequencing ngs method applied develop robust time cost effective diagnostic research tool analyze selected genes related hae entire coding region exon intron boundaries genes subjects brazilian family nine symptomatic analyzed ngs one new mutation found uniquely nine symptomatic patients alapro serping gene estimated likely pathogenic polyphen software analysis main candidate responsible hae patients alterations identified asymptomatic individuals also found almost symptomatic patients ilemet hmwk gluasp nos glyglu may also involved modulating patient specific symptoms ngs gene panel proven valuable tool quick accurate molecular diagnosis hae efficient indicate modulators hae symptoms
background facial port wine stains pws considered aesthetic skin problem yet impact quality life qol objectively documented objective sought characterize effect pws qol adults identify clinical demographic factors affect qol compare results qol studies skin conditions methods total adults facial pws completed online qol survey included skindex instrument results qol adults facial pws diminished especially emotional perspective variables associated reduced qol skindex subdomains included comorbid depression limited facial mobility presence skin conditions persons hypertrophy emotional symptomatic impairment composite dermatologic specific qol scores similar cutaneous cell lymphoma rosacea alopecia vitiligo limitations selection bias potential limitation participants primarily recruited patient support groups conclusion analysis demonstrates presence facial pws significant negative impact qol dermatologists caring patients pws inquire qol provide appropriate support resources consider qol discussing treatment options obtaining authorization procedures
integration electricity heat one promising options achieve sustainable low carbon energy system presence renewable energy sources res respect ongoing studies worldwide aim assessing performance fully integrated energy systems however encouraging terms results planning generally made without considering electrical network constraints missing capture real technical economic performance integrated systems paper new model integrated electricity heat active network management based dual horizon dynamic opf presented model capable plan optimise operations different multi energy technologies considering electrical network associated inter temporal constraints uncertainties allowing assessing potential benefits available flexibility brought energy integration
automatic training agent based simulators complex task common nondeterministic behavior complex relationships input parameters outputs work presents technique called atabs automatically training agent based simulators technique based novel mechanism generating random numbers reduces variability global results work provides framework automates training considering relationships simulation parameters output features technique framework applied automatically train two different simulators current approach empirically compared similar alternative results show atabs outperforms alternative considering similarity simulated real data execution time training process atabs framework publicly available way ensures reproducibility experiments also allows practitioners apply current approach different agent based simulators elsevier rights reserved
plastic encapsulated microcircuits pems used tremendously commercial industrial fields due cost weight availability performance advantages however inherent structures materials pems introduce high risks failures limit use high reliability field screening test package level plays important part improving reliability pems eliminating marginal components early time failures failure analysis microcircuits failed screening test contributes find failure mechanisms helps improve design package reliability however screening test screening failed components failure analysis conducted figure root cause failure contribute conclusion screening test advice design paper dynamic burn screening test plastic encapsulated components presented integrated circuit opaua single operational amplifier fails electrical test hrs failure analysis carried failed components discover root causes turns opaua fails delamination mold compound die pad interface result failure analysis proves thermal mismatch pems causes delamination suggests components also delamination design packaging reliability require lower difference coefficients thermal expansion cte different materials pems
explore effectiveness mentalization based therapeutic intervention specifically developed parents entrenched conflict children best knowledge first randomized controlled intervention study united kingdom work parents post separation first focus mentalization situation using mixed methods study design parents randomly allocated either mentalization based therapy parental conflict parenting together parents group psycho educational intervention separated parents based elements separated parents information program part family justice system approximating treatment usual given challenges recruiting parents difficult circumstances sample size small permitted detection large differences conditions data involving repeated measures related individuals explored statistically using hierarchical linear modeling qualitatively significant findings reported main predicted outcomes clinically important trends measures qualitative findings contributed understanding parents subjective experience pre posttreatment findings indicate larger scale randomized controlled trial would worthwhile encouraging findings shed light dynamics maintaining high conflict situations known damaging children established forms intervention acceptable parents able operate random allocation design extensive quantitative qualitative assessments kind would make larger scale trial feasible productive
prognostic value left ventricular dyssynchrony measured gated single photon emission computed tomography gspect myocardial perfusion imaging mpi relationship electrical dyssynchrony measured qrs duration incompletely understood aim study therefore examine independent incremental prognostic value dyssynchrony yet largest group patients coronary artery disease cad patients presenting gspect mpi july may normal sinus rhythm identified duke nuclear cardiology databank duke databank cardiovascular disease median years deaths occurred years kaplan meier estimates probability death among patients phase bandwidth degrees among bandwidth degrees adjustment standard clinical variables qrs dyssynchrony independently associated death hazard ratio per degrees confidence interval mechanical electrical dyssynchrony together provided prognostic value afforded lvef
ability human brain escape mind wandering take functional problem solving dysfunctional perseverative cognition routes although proposed latter may act mediator relationship stress cardiovascular disease functional dysfunctional forms repetitive thinking associated blood pressure reactivity magnitude however similar reactivity may caused different physiological determinants may differ risk cardiovascular pathology examine way hemodynamic profile extent compensation deficit total peripheral resistance cardiac output compensate determining reactivity functional dysfunctional types repetitive thinking fifty six healthy participants randomly underwent perseverative cognition mind wandering problem solving induction followed min recovery period cardiovascular parameters continuously monitored perseverative cognition problem solving mind wandering elicited increases similar magnitude however perseverative cognition characterized vascular versus myocardial profile compared mind wandering problem solving consequence recovery impaired perseverative cognition compared two conditions given high vascular resistance delayed recovery hallmarks hypertension results suggest potential mechanism perseverative cognition may act mediator relationship stress risk developing precursors cardiovascular disease
advanced design operation consideration close connected winding permanent magnet brushless machine proposed paper including circulating current elimination fault tolerant control breakdown power electronic switch sensorless control method finite element analysis influence machine design parameters circulating current investigated properly controlling status power electronic switches coils connected equivalent circuit changed avoid failure switch sensorless control explored detecting zero crossing point electromotive force
food product safety one promising areas application electronic noses application domain mainly focused quality control freshness evaluation shelf life analysis authenticity assessment paper performance portable electronic nose evaluated monitoring spoilage beef fillets stored either aerobically modified atmosphere packaging different storage temperatures novel multi output fuzzy wavelet neural network architecture developed incorporates clustering pre processing stage definition fuzzy rules dual purpose proposed modelling approach classify beef samples relevant quality class fresh semi fresh spoiled also predict associated microbiological population based total viable counts case aerobic packaging model able classify correctly aerobic samples successful identification microbial counts resulted standard error prediction however modified atmosphere packaging scenario results rather inferior proposed model achieved classification rate samples standard error prediction microbial counts increased comparison results prediction performances models used extensively area food microbiology mlp pls revealed deficiencies anfis svm models revealed robustness providing acceptable prediction performances either aerobic map packaging conditions results evaluation indicated proposed modelling scheme could considered valuable detection methodology food microbiology
last decade keyword search relational data attracted considerable attention possible approach face issue transform keyword queries one sql queries executed relational dbms finding queries challenging task since information represent may modeled across different tables attributes means needed identify schema elements data interest stored also find elements interconnected approaches proposed far provide monolithic solution work instead divide problem three steps first one driven user point view takes account user mind formulating keyword queries second one driven database perspective considers data represented database schema finally third step combines two processes present theory behind approach implementation system called quest query generator structured sources deeply tested show efficiency effectiveness approach furthermore report outcomes number experimental results conducted elsevier ltd rights reserved
decreased responsiveness hypothalamic pituitary adrenocortical axis stress stimuli patients atopy well documented aim study investigate personality traits salivary alpha amylase activity aldosterone response psychosocial stress procedure based public speech atopic patients respect sex menstrual cycle phase study performed subjects sexes atopic patients suffering allergic rhinitis allergic asthma atopic dermatitis age sex phase bmi matched healthy controls substantially attenuated activity alpha amylase reduced secretion aldosterone psychosocial stress observed whole sample patients atopy higher activity alpha amylase observed follicular compared luteal phase healthy women present atopic patients males females atopy associated blunted cortisol response changes heart rate psychological characterization revealed significantly higher trait anxiety higher preference avoidance oriented coping strategy female male atopic patients findings provide evidence patients atopy exhibit insufficient alpha amylase aldosterone responsiveness psychosocial stress thus suggesting decreased sympathetic activity potential disturbances sex hormone status female patients atopy considered future research changes personality traits demonstrated female atopic patients male patients published elsevier ltd
bed rest causes bone loss even otherwise healthy subjects several studies suggest ambulatory subjects may benefit high protein intake stimulate protein synthesis maintain muscle mass however increasing protein intake recommended daily intake without adequate calcium potassium intake may increase bone resorption hypothesized regimen high protein intake hiprot applied isocaloric manner calcium potassium intake meeting recommended values would prevent effect bone turnover day ambulatory adaptation controlled environment women participated day degrees head tilt hdt assigned randomly groups control con subjects received body mass day dietary protein hiprot subjects received protein body mass day plus additional branched chain amino acids per day subjects received individually tailored diet hdtbr kcal day hdtbr kcal day hdtbr kcal day con group diet higher fat carbohydrate intake high protein intake exacerbated induced increase bone resorption marker telopeptide end bone formation markers unaffected high protein intake conclude high protein intake might increase bone loss long duration studies mandatory show positive effect protein muscle mass maintained without risk reducing bone mineral density
background previous studies mostly western women reported inconsistent findings association age menarche risk cardiovascular disease cvd little known association china large intergenerational decrease women mean age menarche methods china kadoorie biobank recruited women aged mean years diverse regional sites across china years follow incident cases stroke coronary heart disease chd cvd deaths reported among women prior history cvd baseline cox regression yielded adjusted hazard ratios hrs relating age menarche cvd risks results mean age menarche years decreasing among women born born patterns association age menarche cvd risk appeared differ different birth cohorts null associations older generations shaped weak positive associations younger women especially born minimizing potential confounding effects major cvd risk factors early late menarche compared menarche age years associated increased risk cvd morbidity mortality pronounced younger generations conclusion among chinese women associations age menarche risk cvd differed birth cohort suggesting factors may underpin association authors published elsevier ireland ltd open access article license http creativecommons org licenses
background aim study investigate national prevalence thyroid dysfunction spain association various clinical environmental demographic variables methods study included subjects men mean age years range years participants national cross sectional population based survey conducted data gathered included clinical demographic characteristics physical examination blood sampling thyrotropin free thyroxine free triiodothyronine thyroid peroxidase antibody tpoab concentrations analyzed electrochemiluminescence urinary iodine levels measured isolated urine sample results prevalence treated hypothyroidism untreated subclinical hypothyroidism untreated clinical hypothyroidism confidence interval respectively prevalence total hypothyroidism including fractions prevalence total hyperthyroidism total population tested positive tpoabs multivariate logistic regression models tpoabs strongly associated hypothyroidism creatinine associated hypothyroidism positive association hypothyroidism remained treated untreated hypothyroidism whereas especially significant non autoimmune tpoabs negative forms positive correlation thyrotropin levels beta negative correlation free triiodothyronine levels beta conclusion according data large proportion spanish population evidence thyroid dysfunction high tpoab concentrations associated hypo hyperthyroidism whereas high concentrations associated hypothyroidism
objective objective study investigate effect relaxation techniques stress anxiety parents hospitalised premature infants three months following discharge neonatal intensive care unit study design randomised controlled trial conducted neonatal intensive care unit tertiary maternity hospital including parents randomised two groups intervention group control group parents intervention group practiced three different relaxation techniques addition undergoing information based training courses parents control group data collection data collected days post delivery three months post discharge assessment measures included perceived stress scale state trait anxiety inventory salivary cortisol levels results psychometric assessment baseline comparable two groups intervention group showed significant reduction trait anxiety compared control group three months post discharge perceived stress decreased groups difference salivary cortisol levels detected multivariate analysis revealed higher initial stress levels university college education associated higher parental stress whereas moderate high income satisfaction associated lower parental stress conclusion long term follow families neonatal intensive care unit experience could assess delayed effects stress management relaxation techniques elsevier ltd rights reserved
letter reports new design method dispersive delay lines coupled line technology based reflective chirped delay line concept continuous modulation even odd mode characteristic impedances symmetrical coupled lines shown produce new structure presents flat magnitude response linear group delay variation along operation frequency band use coupled lines avoids need circulator giving rise practical devices processed signal redirected coupled port instead reflected back input port thus providing valuable effective transmission type operation technique designing device validated ultra wideband signal processing applications
purpose based theories suggesting frequent television viewers act react hostile malicious malevolent verbally aggressive ways rather physically violent present study investigates relationships television viewing different forms bullying methods multilevel regression models estimated based cross sectional data adolescents aged years canada estonia israel latvia macedonia poland portugal united states participated health behavior school aged children survey results although different forms bullying associated television viewing bivariate analyses verbal forms calling mean names spreading rumors remained significant multiple regression models relationships observed consistently eight participating countries however association television viewing physical forms bullying kicking pushing shoving around varied across countries weekend viewing cultures frequent television viewers prone kick push another student addition verbal forms bullying case weekday viewing cultures conclusions results demonstrate importance limiting adolescents time engaged unsupervised television watching need motivate adolescents engage joint family activities organized school activities society adolescent medicine rights reserved
extracellular electrograms recorded atrial fibrillation challenging interpret due inherent beat beat variability amplitude duration phase mapping represents voltage signals terms relative position within cycle widely applied action potential unipolar electrogram data myocardial fibrillation date however applied bipolar recordings commonly acquired clinically purpose study present novel algorithm calculating phase unipolar bipolar electrograms recorded sequence signal filters processing steps used calculate phase simulated experimental clinical unipolar bipolar electrograms algorithm validated action potential phase using simulated data trajectory centre error experimental multi electrode array unipolar bipolar phase wavefront identification clinical atrial tachycardia clinical similar rotational content propagation maps median correlation measured using either unipolar bipolar recordings algorithm robust uses standard signal processing techniques accurately quantifies wavefronts sources identifying critical sources rotors may allow accurate targeting ablation therapy improved patient outcomes
objectives present study identify relationship coping style ptg among survivors years wenchuan earthquake using data cross sectional survey participants recruited two different sites areas severely affected earthquake bivariate correlation analysis multivariate linear regression analysis used assess ptg identify associated factors results indicated positive negative coping style develop ptg among adult survivors years later wenchuan earthquake positive coping style higher correlation new possibilities beta personal strength beta appreciation life beta negative coping style negative coping style higher correlation relating others beta positive coping style addition study found ptsd ptg exist earthquake depression barrier factor process developing ptg elsevier ltd rights reserved
environmental persistence endocrine disrupting estrogen chemicals edc subsequent endocrine function even nanogram concentration environmental matrices garnered significant global attention due possible disruptive effects intact organism progeny attempt made present study investigate occurrence two estrogens viz natural estriol synthetic alpha ethynylestradiol surface waster bodies hyderabad india studied water bodies documented presence estrogens alarming concentrations among six water bodies highest level synthetic estrogen found pedda cheruvu relatively higher concentrations natural estrogen observed alwal tank presence estrogens water bodies might attributed environmental changes socio economic development wide spread use birth control pills direct release agricultural farm waste surface runoff industrial agricultural activities etc compared natural estrogen synthetic estrogen observed higher concentrations water bodies receive domestic sewage mostly middle income groups natural estrogen found higher concentrations water bodies receive water agricultural activities multiple linear regression analysis tailed significance confidence employed predict concentration estrogens based physico chemical parameters water bodies surface plots used evaluate functional role estrogens water quality parameters best knowledge report first study monitoring estrogens indian water bodies
parkinson disease caused loss dopaminergic neurons recently specific weighted magnetic resonance imaging mri tesla reported visualize neuromelanin related contrast dopaminergic neurons using mri analyzed whether disease severity motor complications associated degree dopaminergic neuronal degeneration substantia nigra pars compacta snc patients idiopathic park examined individuals park control group mri used obtain modified sensitive weighted fast spin echo sequence size snc determined number pixels signal intensity higher background signal intensity standard deviations mri indicated hyperintense area snc patients park significantly smaller control subjects compared group without park showed markedly smaller size rich snc area receiver operating characteristic curve analysis revealed sensitivity specificity discriminating patients without area curve correlation analysis hyperintense snc area dopa dopa equivalent dose demonstrated significant negative correlation association reducing snc rich area increasing dopaminergic medication dose suggests mri findings might useful tool monitoring development park
last decades researchers elucidated cognitive motivational conditions affect capacity willingness young alleged victims describe experiences forensic interviewers applied researchers also studied contents features training programs designed help interviewers take advantage research developmentally appropriate interviewing latter studies highlighted knowledge transfer problem scientists understand best practice techniques well many interviewers believe understand employ practices widespread training limited impact actual quality interviews conducted field clear evidence improvements interviewing practice occur reliably training courses involve multiple modules distributed time repeated opportunities interviewers consolidate learning obtain feedback quality interviews conduct barriers implementation training discussed
since galileo used pulse measure time period swinging chandelier century pendulums fascinated scientists stokes camb phil soc whose interest spurred pendulur time pieces mid century treatise viscous flow theoretical framework drag sphere low reynolds number laid stokes famous drag law used determine two fundamental physical constants charge electron avogadro constant used theories three nobel prizes considering illustrious history surprising flow past sphere two dimensional analog flow past cylinder form starting point teaching flow past rigid body undergraduate level fluid mechanics courses usually starting two dimensional potential flow past cylinder students progress three dimensional potential flow past sphere however viscous flow past rigid bodies taught three dimensional example sphere first introduced followed often two dimensional viscous flow past cylinder reason viscous flow past cylinder generally taught usually explained asymptotic analysis perspective fact added mathematical complexity drag cylinder solved years drag sphere note show viscous flow past cylinder explained without need introduce asymptotic analysis still capturing physical insight classic fluid mechanics problem
background non vitamin oral anticoagulants proven alternatives vitamin antagonists stroke prevention atrial fibrillation however data efficacy safety use cardioversion risk thromboembolic events heightened methods performed random effects meta analysis patients undergoing electrical pharmacologic cardioversion atrial fibrillation rocket aristotle engage timi vert ensure trials assessed mantel haenszel pooled estimates risk ratios rrs confidence intervals cis stroke systemic embolism major bleeding days follow results analysis pooled patients cardioversions atrial fibrillation performed compared vitamin antagonists non vitamin antagonist oral anticoagulant therapy associated similar risk stroke systemic embolism major bleeding found significant statistical heterogeneity among studies cochrane stroke systemic embolism major bleeding conclusions short term incidence thromboembolism major bleeding cardioversion non vitamin antagonist oral anticoagulants comparable incidence observed dose adjusted vitamin antagonist therapy non vitamin antagonist oral anticoagulants reasonable alternative vitamin antagonists patients undergoing cardioversion elsevier inc rights reserved
remote sensing based retrieval concentrations water components relies largely accuracy atmospheric correction although variety atmospheric correction algorithms developed turbid waters water leaving reflectance still underestimated extremely turbid waters changjiang yangtze estuary adjacent coast address issue paper proposes improved algorithm based spectral optimization algorithm esoa coupled water atmosphere model model combines aerosol model constructed aerosol robotic network aeronet observation data simple semi empirical radiative transfer sert model shen water component retrieval four unknown parameters involved coupled model relative humidity fine mode fraction fmf aerosol optical thickness near infrared nir wavelength tau lambda suspended particulate matter spm concentration spm parameters estimated global optimization approach based genetic algorithm without initial inputs validation results atmospherically corrected remote sensing reflectance lambda matchups geostationary ocean color imager goci data situ data show algorithm satisfactory accuracy root mean square error rmse absolute percentage difference apd respectively contrast lambda values retrieved matchups using goci data processing system gdps higher rmse apd respectively esoa method implemented conveniently within open source code seadas alternative operational tool atmospheric correction ocean color data including goci meris modis highly turbid estuarine coastal regions yangtze estuary hangzhou bay coastal ocean eastern china elsevier inc rights reserved
present approach development specialized knowledge internet portal work large quantities information computational resources field strength materials ontology based portal provides information basis design alloys represented chosen fields science may difficult formalizing allows use web services realization engineering tasks internet material science knowledge accumulated databases
hts superconducting coils components rotating electrical machines made icpe work liquid nitrogen temperature made ceramic material ybco type critical current superpower respectively amsc analyzed two different types coil two prototypes electrical machines electric motor electric generator made hts tape form simple double racetrack pancake within paper design parameters hts coils examined also generated magnetic field field numerical simulation optimal functioning conditions analyzed
semiconductor photocatalysis promising approach combat environmental pollution global energy shortage advanced tio based photocatalysts novel photoelectronic properties benchmark materials pursued high solar energy conversion efficiency among different morphological tio nanostructures tio nanobelts nbs attract attention due unique physical properties ideal ribbon like morphology favorable constructing heterostructures assembling second phase nanoparticles surface nbs large number studies proven well designed tio heterostructures broaden photocatalytically active light band tio also enhance light absorption performance photo induced carrier separation ability tio heterostructure become versatile powerful tool building high performance tio based photocatalysts stimulated intense research activities focused growth properties applications tio heterostructures review attempts cover aspects including underlying principles key functional features tio nbs tio heterostructures comprehensive way also discuss prospects type novel hybrid photocatalyst elsevier rights reserved
paper give solution problem projecting point onto intersection several closed convex sets projection individual convex set known existing solution methods problem sequential nature propose highly parallelizable method key idea approach reformulation original problem system semi smooth equations benefits proposed reformulation twofold fast semi smooth newton iterative technique based clarke generalized gradients becomes applicable mechanics iterative technique almost decentralized solution method emerges proved corresponding semi smooth newton algorithm converges near optimal point quadratically features make overall method attractive distributed computing platforms sensor networks elsevier inc rights reserved
work presents three phase harmonics measurement method based msdft modulated sliding discrete fourier transform variable sampling period technique proposal allows measuring harmonic components three phase signal computes corresponding imbalance estimating positive negative zero sequence addition adaptive variable sampling period used order obtain sampling frequency multiple main frequency msdft high rejection distortions electrical network flexibility proposed method makes interesting alternative design grid power monitors
abrasive microwear testing subject significant amount research recent years potential evaluate behaviour thin coating became relevant aim work build apparatus abrasive microwear testing rotating sphere abrasive contact performed aisi steel ball rotates great accuracy help electric motor relation flat sample remain stationary normal load applied weight adjustments support test specimen varied performed test device used determine abrasive wear resistance effectiveness surface treatments used parts undergo kind requirement service also studying new products developed increasing wear resistance surfaces microwear resistance quenched tempered aisi steel evaluated observed increasing hardness treated material produced increased wear resistance compared untreated material
context emergency contraception use drug device prevent pregnancy unprotected sexual intercourse unlike regular methods contraception taken prior sexual act used unprotected sex aim assess knowledge attitude toward use emergency contraceptives among medical students setting design cross sectional questionnaire based study conducted among medical students government medical college north west india subjects methods questionnaire seeking information knowledge attitude undergraduate medical students administered period weeks month february march statistical analysis data entered excel expressed using percentages chi square test used test statistical significance results participants aware timing use audio visual media common source information medical students conclusions lack appropriate depth knowledge among future health care professional alarm medical teaching system method used prevent pregnancy unprotected sex contraceptive accident
read circuit critical component needed infrared visible light imaging system advances image sensors microelectronics led development digital read fabricated using deep sub micro integrated circuit techniques brief review given image sensor developing major adaptation circuit review including source follower direct injection capacitance trans impedance amplifier chip analog signal processing analog digital conversion techniques also discussed noise shaping modulation promising technique build low power ultra small area high precision pixel level convertor
background sports related maxillofacial injuries contribute significant proportion workload maxillofacial unit aim study identify incidence maxillofacial sports related injuries treatments required assess impact injury future sport participation method retrospective review carried maxillofacial trauma referrals september august patient records reviewed following variables recorded age sex sport involved injury sustained mechanism injury treatment subsequent participation interval return sport results study population included patients sports related facial injuries common sporting injuries follows gaelic football soccer rugby equine sports common injury sustained zygomatic complex fracture mandibular fracture occurred orbit fracture nasal bone fracture common mechanism injury clash heads followed elbow face majority patients resumed participation chosen sport mean interval weeks range weeks conclusions study identified significant number sporting facial injuries presented year total patients underwent surgical procedure management injuries study highlights need educate players regarding use personal protective equipment adherence rules sports
aim context increasing focus indicated prevention psychotic disorders describe operation clinic assessment youth risk cayr years specialized service identification monitoring treatment young individuals meet ultra high risk uhr criteria psychosis integration within prevention early intervention program psychosis pepp montreal canada methods outline rationale development inclusion exclusion criteria assessment services offered community outreach liaison potential referral sites research focus risk protective factors related neural diathesis stress model psychosis results january december cayr received referrals accepted patients met uhr criteria based comprehensive assessment risk mental states conversion rates first episode psychosis research findings point high subjective stress levels poor self esteem social support coping skills dysregulation hypothalamus pituitary adrenal axis high risk phase conclusions efforts community outreach resulted increasing numbers referrals patients accepted cayr highlighting relevance need high risk programme montreal area patients psychotic symptoms immediately assigned first episode psychosis clinic within pepp likely contributed low conversion rates observed uhr group research findings stress protective factors emphasize importance psychosocial interventions high risk patients
present study investigates people perceived likelihood experiencing negative emotion response potentially jealousy inducing facebook wall post ostensibly sent rival facebook messages varied participants viewed message containing text text plus either attractive unattractive photo sender winking face emoticon words capitals triple exclamation points participants asked indicate degree negative emotion would feel saw message romantic partner facebook wall addition wink face emoticons physical attractiveness cues facebook wall post contributed differences likely experienced emotion participants also reported greater likelihood experiencing negative emotion high preoccupied attachment low dismissive attachment finally women reported likely experience negative interpersonal affect response facebook post men implications role nonverbal cues play computer mediated contexts facebook discussed
assess thermal hydraulics condenser typical automotive air conditioning system maldistribution intake air comprehensive investigation taken investigation comprises experiments numerical simulations special purpose software coildesigner used simulate heat transfer fluid dynamics multiple channel micro tube air refrigerant crossflow condenser experimentally overall performance condenser studied creating blockages different types extents inlet air path simulation results provide spatial variation pressure temperature heat transfer coefficient quality tube side addition overall performance cases simulation results clearly bring spatial change transport parameters due typical blockage one compare effective use exchanger area heat exchanger unblocked typically blocked case simulation also gives reliable prediction overall performance recorded experiment elsevier ltd rights reserved
clinical implementation new carbon fiber reinforced polyetheretherketon peek plate distal radius fractures might offer advantageous properties conventional metallic devices includes similar elastic modulus cortical bone radiolucency low artifacts mri scans lack metal allergies aim study evaluate clinical results week month follow using either new fixed angle monoaxial peek plate system fixed angle polyaxial titanium plate included patients mean age displaced fractures distal radius types radiological functional outcomes measured prospectively week month follow documented cases hardware breakage significant loss surgically achieved fracture reduction usage oft new peek device operating time min using peek versus min titanium plates recorded times including preparation draping postoperative processing week follow peek plate showed trend better range motion functional results dash score mayo wrist score vas statistical significance results month follow peek showed comparable results corresponding studies examining titanium plate period first experience peek plate osteosynthesis demonstrate quick clinical implementation good clinical outcome advantage excellent postoperative radiological assessment early follow peek even showed trend improved functional results
amidst ongoing debate surrounding traditional dichotomy whether video games good bad children paper present path trust novel prosocial game aims helping children understand importance teamwork learn express trustworthiness created colorful non violent digital game children aged exposed prosocial content develop specific prosocial attitudes cooperation trustworthiness driven fact video games prosocial content used improve social interactions game designed maintain attractive engaging nature usually associated games often vilified within social circles terms packed tons action violence conducted two separate studies test game modeling prosocial behavior demonstrate potential game tool teaching important prosocial behavior children
background microbial production nitrogen containing compounds requires high uptake flux assimilation source commonly ammonium generally coupled atp consumption negatively influences product yield industrial workhorse saccharomyces cerevisiae ammonium uptake facilitated ammonium permeases mep mep mep transport ion resulting atp expenditure maintain intracellular charge balance proton export using plasma membrane bound atpase results decrease atp costs nitrogen assimilation mep genes removed resulting strain unable uptake ion subsequent analysis revealed growth delta mep strain dependent extracellular concentrations metabolomic analysis revealed significantly higher intracellular nhx concentration fold delta mep strain reference strain proteomic analysis revealed significant regulation vacuolar proteases genes involved various stress responses conclusions results suggest uncharged species able diffuse cell measured intracellular extracellular nhx ratios aerobic nitrogen limiting conditions consistent hypothesis nhx compartmentalization considered hand proteomic analysis indicated pronounced starvation stress response delta mep strain reference strain suggests lower biomass yield delta mep strain related higher turnover rates biomass components
construction one hazardous industries due dynamic temporary decentralized nature hong kong commissioner labor identifies worker behavior root cause construction accidents behavior based safety bbs one effective approach managing employee safety issues however little research application bbs construction industry research proposes extension bbs approach proactive behavior based safety pbbs improve construction safety pbbs integrates theory bbs technology proactive construction management system pcms innovations pbbs automatically monitoring location based behaviors quantitatively measuring safety performance investigating potential causes unsafe behaviors improving efficiency safety management pilot study hong kong construction site practicing pbbs conducted experiment results showed pbbs performed well construction accident prevention safety index two project teams increased improvements respectively concluded pbbs effective adaptable construction industry elsevier ltd rights reserved
triterpenoid saponins saponinum album exert potent lytic effects eukaryotic cell plasma membranes used sub lytic concentrations significantly augment cytotoxicity saporin based immunotoxins help elucidate mechanism behind two phenomena investigated role cholesterol human daudi lymphoma cells lipid deprived using combination three different approaches following treatment total cellular lipid content analyzed electrospray ionization mass spectrometry esi plasma membrane cholesterol content measured using lipophilic fluorescent probe nrs maximal lipid deprivation cells resulted complete loss sensitivity lysis similarly augmentation anti immunotoxin saporin lost without concomitant loss intrinsic cytotoxicity lytic activity restored following incubation lipid deprived daudi cells synthecol ldl augmentative effect cytotoxicity daudi cells restored following repletion cholesterol levels ldl nrs fluorescence esi analysis cellular lipids demonstrated restoration lytic activity synthecol entirely due increased cholesterol levels restoration cellular cholesterol levels ldl also restored augmentative effect effect associated repletion cholesterol minor changes phospholipid species results indicate lytic augmentative properties cholesterol dependent contrast intrinsic cytotoxicity least partially cholesterol independent elsevier rights reserved
metacognition capacity reflect upon one knowledge key trait cognitive repertoire developed childhood direct comparison metacognitive ability children years old adults using single perceptual task made results showed years old children level metacognitive access similar adults signal detection theory model applied order distinguish metacognitive ability propensity towards risk taking two factors far confounded studies children presented suboptimal tendency towards risky decisions natural predisposition overconfidence partially mitigated imposing conservative normative strategy elsevier inc rights reserved
data provenance history associated data constitutes origin creation processing archiving data today internet era gained significant importance database analytics provenance models store provenance information relational databases querying analysis although querying provenance relational databases efficient small data sets becomes inefficient provenance data grows traversal depth provenance query increases mainly due increase number join operations search entire provenance data graph databases provide alternative rdbmss storing analyzing provenance data scale billions nodes time traverse thousands relationships efficiently paper propose efficient multi depth querying provenance data using graph databases proposed solution allows efficient querying provenance current well historical queries comparison relational graph databases presented varying provenance data size traversal depths graph databases found scale well increasing depth provenance queries whereas relational databases querying time increases exponentially
research begun addressing food insecurity hiv positive populations knowledge regarding among individuals living hiv hepatitis virus hcv infection limited exploratory study examines sociodemographic socioeconomic behavioral clinical factors associated cohort hiv hcv infected individuals canada analyzed longitudinal data food security hiv hcv infection study canadian infection cohort collected november june health centres measured using household food security survey module classified using health canada criteria generalized estimating equations used assess factors associated among participants experienced first study visit baseline protective factors associated included enrolment quebec study site aor employment aor average personal monthly income aor per cad increase risk factors included recent injection drug use aor trading away food aor recent experiences depressive symptoms aor common infected population engagement infected individuals substance use treatments harm reduction programs mental health services may mitigate vulnerable subset hiv positive population
pre adolescent adolescent gymnasts especially artistics gymnasts rhythmic gymnasts belong high risk group severe deficiency lack basic nutrients especially calcium iron folic acid vitamin zinc increased demands accelerated pubertal development combination need maintain reduced body mass intense daily training without energy recovery adequate rest expose particularly younger athletes growth disorders long term nutritional deficiencies problems emotional nature low self esteem dissatisfaction body image multiple daily weighing obsessions body aesthetics physical appearance hormonal disorders amenorrhea premature fatigue osteopenia particularly increased risk injury vast majority athletes feel constant chronic diet typical athletes spend hours daily training water intake snack coaches aware detection diagnostic assessment nutritional deficiencies shortcomings future nutrition dependent disorders developmental ages gymnast field study every qualified sport dietician keeping mind purpose review provide targeted nutritional support directions elite athletes priority emphasis strengthening immune system nutritional strategy direct energy recovery control timely daily food intake annual training season
purpose evaluate application whole genome sequencing wgs determining inter foci clonal relationship multifocal papillary thyroid carcinoma mptc methods reviewing ptc patient profiles cancer foci germline control samples mptc patients analyzed wgs single nucleotide variations snvs copy number variation cnv structural variation mutational signature examined results multifocality rate ptc mptc shown larger primary tumor diameter higher rate lymph node metastasis less number accompanying non cancerous lesions single ptc one gender groups cancer foci foci identified clonal independent model rest foci clonal derived model according exonic snvs spectrum non exonic mutations provided compelling evidence genome wide level classification specific cnv mutational signatures also identified conclusions wgs could impressive tool clonal relationship determination ptc providing panoramic view genome wide somatic mutations substantial sequencing data provided additional information could help studying mechanism carcinogenesis elsevier rights reserved
paper proposes parallel word alignment procedure binary complement insertion mbc differential binary mark insertion dmbm line code proposed procedure mbc line code word alignment circuit searches bit pairs parallel complementary relationships signal flow graph model parallel word alignment procedure also proposed performance attributes numerically analyzed attributes compared conventional bit bit procedure shown proposed procedure displays superior performance terms false alignment probability maximum average aligning time proposed procedure suitable high speed optical data links easily implemented using parallel signal processor operating clock rare equal times mbc line rate
paper focuses design experimental test results belt driven starter generator mini hybrid powertrains functionalities required system engine startup launch assistant torque regenerative braking battery charging early fuel cutoff cost effective electrical machine must provide high starting torque wide constant power speed range motor generator modes authors outline motivations electrical machine topology selection relation specifications constraints particular double three phase induction machine selected suitable candidate aim paper summarize design challenges kind electrical machines mainly subordinated electromechanical thermal issues imposed considered hybridization solution details machine design presented including study multilayer bar stator windings rotor slot design finally predicted measured performances prototype reported discussed validation purposes
work deals performance evaluation conflicting timed event graph cteg class petri net exhibiting phenomena synchronization parallelism resources sharing well known dynamic timed event graphs teg admits linear state space representation max algebra makes analysis control class easier also possibility associating conflicts tegs adding conflict places mostly considered safe extended class called cteg first present analytic evaluation cycle time cteg function cycle time teg timers conflict places finally general context look relaxation safety hypothesis conflict places order model evaluate cycle time ctegs multiple shared resources
article investigates dynamic interaction horizontal axis wind turbine modelled discrete euler lagrangian system soil foundation system modelled finite element framework model comprises rotor blade system nacelle flexible tower connected soil foundation system using substructuring approach aerodynamic loading rotor blades modelled using blade element momentum theory offshore wind turbine founded monopod suction caisson foundation soil foundation system modelled using finite element method plaxis dynamics strength materials based wave propagation approach cone method comparison dynamic stiffness matrix static stiffness matrix formulation used represent soil foundation behaviour mudline tower displacement response transfer functions generated using soil foundation model various soil stiffness effects soil stiffness displacement transfer functions wind turbine dynamics discussed results static stiffness formulation coupling seen match given frequency dependent models indicating simplified models maybe used analysis certain conditions
keapl constitutively binds transcription factor nrf promote degradation resulting negative modulation genes involved cellular protection oxidative stress keapl increasingly recognized attractive target treating diseases involving oxidative stress including cancer atherosclerosis diabetes arthritis neurodegeneration used phage display peptide screening identify tetrapeptide showing moderate binding affinity inhibits interaction nrf keapl tetrapeptide include etge motif commonly found consensus sequence known peptidic inhibitors addition affinity parameters thermodynamic parameters crystal structure complex determined elucidate binding conformation binding interactions resemble known small molecule inhibitors opposed substrates peptidic inhibitors although tetrapeptide affinity high results may help facilitate designing small molecule inhibitors lead generation drug discovery elsevier inc rights reserved
objective investigate relationships pain stress social support sleep disturbance among diverse sample hiv positive adults method participants completed self report measures pain stress social support sleep disturbance cell count obtained medical records results greater pain stress associated greater sleep disturbance greater assistance friends associated greater sleep disturbance whereas greater understanding friends regarding participants hiv related stress associated less sleep disturbance conclusion expected pain significantly associated sleep disturbance additionally psychosocial variables strongly associated sleep type support friends differentiated whether support positively negatively associated sleep problems social support depending type may always helpful adults living hiv aids future studies need examine factors may mediate relationship psychosocial constructs healthy sleep elsevier inc rights reserved
dextromethorphan recognized substance abuse around world estimated million people ages years misused counter cough cold medications study developed serum metabolomic method gas chromatography mass spectrometry evaluate effect abuse dextromethorphan rats dextromethorphan treated rats given low medium high dextromethorphan intragastric administration day days partial least squares discriminate analysis revealed intragastric administration dextromethorphan induced metabolic perturbations compared control healthy group levels propanoic acid urea heptafluorobutanoic acid hexyldecanoic acid butanedioic acid low group decreased levels propanoic acid heptafluorobutanoic acid medium group decreased benzoic acid increased levels hexyldecanoic acid glycerol butanedioic acid high group increased biomarkers involved citric acid cycle urea cycle glycerolipid metabolism tricarboxylic acid cycle results indicate metabolomic method may useful elucidate abuse dextromethorphan according pathological changes liver different dosages dextromethorphan hepatotoxic intragastric administration days
order research field sensing characteristic carbon fiber smart material tikhonov regularization principle modified newton raphson mnr algorithm adopted solve inverse problem electrical resistance tomography ert ert system carbon fiber smart material developed field sensing characteristic researched experiment experimental results show specific resistance distribution carbon fiber smart material highly consistent distribution structural strain high resistance zone responds high strain area specific resistance distribution carbon fiber smart material reflects distribution sample strain covering area monitoring carbon fiber smart material complicated strain status sample field domain realized theoretical experimental study
purpose study find patterns latent profiles behavioral problems children aged child caregiver variables affected composition latent profile group differences children social skills latent profile groups study relies sample children enrolled panel study korean children fostering children social abilities stressed recent policy documents korea including character education promotion act recently introduced nuri curriculum therefore current paper investigates factors influencing children behavior problems via longitudinal analysis latent profile analysis performed resulted three profile models findings follows first according latent profile children behavior problems came three group models best fit data group named non problem group ages standard scores behavioral problems group named normal group average slightly average scores behavioral problems though problems decreased child got older group named danger group average standard scores externalizing behavioral problems scores internalizing behavioral problems subclinical standard point age clinical standard point ages second exploring influencing factors child parent levels children belonging danger group study found child likely belong danger group female level activity sociality low mother parenting stress high family income low lastly study looked whether group differences young children social skills findings show regarding capacity cooperation self control scores non problem group higher danger group regarding capacity exhibiting assertiveness responsibility lowest scores among three groups belonged danger group
one main problems micro unmanned aerial vehicles uav endurance flight time since general domain aircraft use conventional fuel using conventional fuel pollutant limited life costly huge demand using unlimited non exhaustible source energy fuel solar energy one available renewable energy used increase endurance uav without adding significant mass increasing size fuel system considering basic challenges solar powered aircraft geographical area operation energy collection storage payload design parameters plane designed fabricated incorporating solar cells onto wing first much energy available sun power entire plane conceptually analyzed verified experimental results finally energy exergy efficiencies calculated analyzed exergy important tool addressing influence utilizing energy resources environment elsevier ltd rights reserved
autism spectrum disorders asd pervasive neurodevelopmental disease characterized deficits social interaction nonverbal communication well restricted interests stereotypical behavior genetic changes heritability one major contributing factors hundreds thousands causative susceptible genes copy number variants cnvs linkage regions micrornas associated asd clearly indicates asd complex genetic disorder briefly summarize high confidence genetic changes asd possible roles pathogenesis
power source used wireless power transfer generates wave transfer electric power load connected electrically connected electromagnetically power source paper power efficiency compared sinusoidal square waves typical waves applied power source voltage outputs condition two waves respectively transfer equivalent power electric wires examined figure effect different waves power efficiency calculated mathematical approach practical values elements various situations finally paper explores input waves chosen ideal wireless power transfer
objectives beta glucan assay bdg added eortc msg criteria diagnosis invasive fungal infections ifi data pediatric populations scarce aim study evaluate performance bdg cohort hemato oncological children hematological malignancy risk ifi methods patients included month period addition routine ifi screening bdg assayed week ifis classified using eortc msg criteria without including bdg results performances assessed roc analysis optimization multivariate analysis detect causes false positivity results proven probable ifis possible ifis diagnosed patients respectively sensitivity specificity increased respectively considering whole population patients received antifungals prior test multivariate analysis revealed younger severe colitis mucositis recent administration polyvalent immunoglobulins digestive colonization enterococcus independent risk factors false positivity conclusions bdg valuable test detect ifi pediatric patients previously treated antifungals detect occurrence chronic infection british infection association published elsevier ltd rights reserved
study investigates continuing production media effects research focuses media violence aggression connection analyzing production trends characteristics evidenced archive journal articles analysis found archive marked initiatives governmental funding private philanthropy shifting disciplinary interests cycles editorial attention economies disciplinary authentication professional legitimation analysis mainline arguments indicated shift audience activated effect one individual unwitting accomplice finally study showed continuing interest media serves deflect attention much serious much costly remedy sources aggression elevate role media level importance
solar energy enormous potential solve society energy needs sustainable way notably photovoltaic systems permit obtain electricity based solar energy however issues must addressed establish reliable source electrical power example low energy density one approaches improve performance systems utilize solar spectrum solar cells efficiently downconversion process high energy photon converted two photons lower energy trough downconversion possible use wider portion solar spectrum raising efficiency different kinds solar cells present paper reviews state art materials methods used take advantage downconversion processes solar cells discuss pros cons different designs solar cells well main characteristics materials utilized
known hiv positive intravenous drug user found human cell lymphoma leukemia virus htlv dna positive polymerase chain reaction seronegative screening elisa consistently dna positive took years fully seroconvert sequencing htlv strain cultured lymphocytes indicated prototypical type strain major differences long terminal repeat dna sequence major amino acid differences gag env tax rex proteins however mutation pol gene created stop codon amino acid pol protein region encodes rnase function mutation may account subject slow seroconversion
background obesity caused imbalance energy intake eating energy expenditure severe obesity prevalent women men worldwide obesity pathophysiology resultant obesity related disease risks differ women men underlying mechanisms largely unknown pre clinical clinical research indicate ovarian hormones may play major role objective rationale systematically reviewed clinical pre clinical literature effects ovarian hormones physiology adipose tissue regulation mass energy intake search methods articles english indexed pubmed january searched using keywords related reproductive hormones weight regulation iii central nervous system sought identify emerging research foci clinical translational potential rather provide comprehensive review outcomes find estrogens play leading role causes consequences female obesity respect adiposity estrogens synergize genes increase gluteofemoral subcutaneous mass decrease central mass reproductive age women leads protective cardiometabolic effects loss estrogens menopause independent aging increases total mass decreases lean body mass little net effect body weight menopause also partially reverses women protective distribution effects counteracted estrogen treatment respect eating increasing estrogen levels progressively decrease eating follicular peri ovulatory phases menstrual cycle progestin levels associated eating luteal phase appear causal relationship progestins may increase binge eating eating stimulated negative emotional states luteal phase pre clinical research indicates one mechanism pre ovulatory decrease eating central action estrogens increase satiating potency gastrointestinal hormone cholecystokinin another mechanism involves decrease preference sweet foods follicular phase genetic defects brain melanocycte stimulating hormone melanocortin receptor melanocortin receptor mcr signaling lead syndrome overeating obesity particularly pronounced women female animals syndrome appears around puberty mice genetic deletions mcr suggesting role ovarian hormones emerging functional brain imaging data indicates fluctuations ovarian hormones affect eating influencing striatal dopaminergic processing flavor hedonics lateral prefrontal cortex processing cognitive inhibitory controls eating dearth research neuroendocrine control eating menopause also comparatively little research effects ovarian hormones although changes ovarian hormone levels menstrual cycle affect resting wider implications markedly greater obesity burden women makes understanding diverse effects ovarian hormones eating body adiposity urgent research challenges variety research modalities used investigate effects women mechanisms reviewed accessible animal models therefore human translational research roles ovarian hormones women obesity causes intensified gain mechanistic insights may ultimately translated novel anti obesity therapies thereby improve women health
development country malaysia facing challenge develop economic liked others economic changing agriculture manufacturing drastic change need people also adapt situation days changing become issues changing work life agriculture manufacturing changing technologies changing people thinking etc previous studies found major issues majority graduate enough employability skills day day issues keep challenges malaysian government also students institutions previous study found pbl alternative overcome changing delivery applied applied subjects taken applied mathematics students facing problem applied mathematics students subjects attractive using pbl alternative methodologies facing day future issues research study effectiveness pbl alternative tool enhancing employability skills among graduates study adopts combination qualitative quantitative approaches data shall collected using documents analysis students sample quasi experimental study comprise manufacturing engineering undergraduates several public institutions higher learning malaysia result shows student enhanced employability skills pbl furthermore student competitive become relevance industries need employability skills shown applied mathematics helping pbl also valuable become major function catalyst employability skills elsevier ltd rights reserved
among minorities underserved today healthcare system lesbian gay bisexual lgb population may least studied least understood healthcare providers high quality evidence often lacking regarding optimal preventive care measures medical areas date fail identify differences need lgb heterosexual patients prevalent specific sexual minorities issues substance abuse sexual health sexually transmitted diseases obesity eating disorders cardiovascular prevention cancer prevention screening depression psychological disorders social isolation personal intimate partner violence important address lgb patients general american population although many barriers delivery quality healthcare patients exist support governmental professional private organizations assist patients providers overcoming barriers
sparked conjunction food fuel financial crises increasing awareness recent years scarce finite character natural resources productive resources agricultural land touted financial actors merchant banks pension funds investment companies providing basis range new alternative financial asset classes products drivers motives rationales behind increasing interest turning farmland financial asset class traced number scholars interpretations interactions financial actors community level received less attention based qualitative research rural australia paper reveals grounds finance backed investments accepted accommodated communities rural australia delineates reasons led feelings unease refusal paper thereby demonstrates financialization farmland neither abstract one sided rather multidimensional process includes financial actors also impacted rural populations various ways positioning activities financial actors australia within emerging research financialization farmland paper endorses context sensitive analyses better interpret recent transformations agri food system
purpose review human gastrointestinal lumen inhabited wide variety microbiota understanding intestinal microbiota full consequences gastrointestinal health still evolving however well accepted altered colonic flora drives pathogenesis many disorders diseases seen antibiotic associated diarrhea clostridium difficile infection recent works published area probiotics reviewed recent findings alterations colonic microbiota dysbiosis implicated irritable bowel syndrome inflammatory bowel diseases probiotics prebiotics evolving treatment options targeted restoring nonpathogenic digestive flora great interest role therapies treatment many diseases including childhood diarrhea antibiotic associated diarrhea clostridium difficile infection irritable bowel syndrome inflammatory bowel disease summary trials probiotics shown helpful others work needed others review recent work done areas
previous research shown arbitrary stimuli acquire valence facial expressions convey different emotions become members equivalence class present study investigated whether stimuli shifted class membership became equivalent another facial expression would change valence accordingly fifty four college students formed equivalence classes abcd abcd abcd facial expressions happiness neutrality anger respectively semantic differential ratings showed acquired valences equivalent facial expressions training class reorganization conducted altering relation would become equivalent expressions happiness neutrality anger respectively training conducted delayed matching sample format one group participants simultaneous matching sample format another group asked rate stimuli participants showed class reorganization showed valence changes according facial expression stimuli became equivalent training altered relation valence changed participants trained class reorganization delayed matching participants pass test class reorganization show changes valence stimuli results indicate training parameters affect extent stimuli change meaning shift membership equivalence classes
background although significant subset patients major depressive disorder mdd fail respond medical behavioural therapy deep brain stimulation dbs applied subgenual cingulate cortex scc shown reduce depressive symptoms subset patients area receives projections neurons region subiculum hippocampus brain region implicated pathobiology treatment mdd objective assess whether high frequency stimulation hfs infralimbic cortex associated changes cellular morphology methods rats subjected either infralimbic hfs sham stimulation measures cellular morphology including dendritic length complexity assessed pyramidal neurons region means golgi cox histological stain results dendrite length number branch points significantly increased across entire dendritic tree animals subjected hfs subsequent scholl analysis revealed dendritic length effects localized region soma either interval basal dendritic tree branch point number predominantly increased soma apical dendritic tree conclusions high frequency stimulation infralimbic cortex increases complexity apical dendrites length basal dendritic trees pyramidal neurons located cal hippocampal subfield relative sham stimulated animals elsevier inc rights reserved
background objectives psoriasis inflammatory skin disease associated metabolic syndrome insulin resistance irisin adipokine myokine regulates metabolic status times increased insulin sensitivity study aimed investigate changes serum level irisin psoriasis patients comparison participants disease control group hope results study would also aid establishing protocol aimed understanding etiopathogenesis treatment psoriasis materials methods study included patients psoriasis vulgaris presented dermatology outpatient clinic receiving systemic treatment control group included voluntary participants disease addition venous salivary irisin levels glucose triglyceride cholesterol high density lipoprotein low density lipoprotein levels homeostasis model assessment insulin resistance scores measured control patient groups results serum irisin salivary irisin levels significantly lower patient group compared control group patient group serum irisin levels positive correlation salivary irisin levels negative correlation psoriasis area severity index dermatological life quality index scores conclusion first study evaluating irisin levels patients psoriasis vulgaris literature results study show serum salivary irisin levels significantly lower patient group compared control group irisin levels patients severe psoriasis low suggesting irisin may role pathogenesis psoriasis may marker showing severity psoriasis could warn development insulin resistance diabetes mellitus copyright taiwanese dermatological association published elsevier taiwan llc
exposure childhood trauma associated psychotic symptoms ultra high risk psychosis uhr psychotic disorders schizophrenia negative self beliefs shown partially mediate relationship childhood trauma paranoia shown characteristic patients psychosis however whether association childhood trauma high risk developing psychosis uhr paranoia symptoms mediated altered cognitive schema unknown warrants investigation inform preventive interventions data collected uhr patients outreach support south london exposure childhood trauma cognitive schema paranoia cannabis use relative healthy controls uhr patients significantly likely report exposure various types childhood trauma emotional sexual abuse emotional physical neglect negative schema less positive schema others likely use cannabis month emotional neglect found significantly associated uhr status even controlling effects previous exposure cannabis use association partially mediated negative self schema similarly emotional neglect significantly associated paranoia association partially mediated negative self schema findings provide preliminary evidence cognitive mechanisms may underlie association childhood trauma later risk psychosis elsevier ltd rights reserved
empathy pain often described automatic used implicit measurement multinomial modeling formally quantify unintentional empathy pain empathy occurs despite intentions contrary developed pain identification task pit sequential priming task wherein participants judge painfulness target experiences trying avoid influence prime experiences using multinomial modeling distinguished component processes underlying pit performance empathy toward target stimuli intentional empathy empathy toward prime stimuli unintentional empathy bias judge target stimuli painful response bias experiment imposing fast slow response deadline uniquely reduced intentional empathy experiment inducing imagine self imagine perspective taking uniquely increased unintentional empathy experiment intentional unintentional empathy stronger toward targets typical atypical pain outcomes suggesting outcome information matters effects pit reducible affective priming typicality pain outcomes weakly affected task performance target stimuli merely categorized rather judged painfulness suggesting effects latter reducible semantic priming experiment unintentional empathy stronger participants engaged costly donation cancer charities parameter also high donated objectively worse socially popular charity suggesting overly high empathy may facilitate maladaptive altruism theoretical practical applications modeling approach understanding variation empathy discussed
home building automation hba trends toward ambient intelligence paradigm aims autonomously coordinate control appliances subsystems given environment nevertheless hba based explicit user home interaction basically enables static predetermined scenarios paper proposes flexible multi agent approach leveraging semantic based resource discovery orchestration hba applications backward compatible enhancements eib knx domotic standard allow support semantic characterization user profiles device functionalities thus enabling negotiation suitable home services functionalities according implicit explicit user needs device driven interaction adapting environment context evolution power management problem hba presented case study better clarify proposal assess effectiveness
present study aimed determine effect green tea supplement anthropometric indices inflammatory factors women polycystic ovary syndrome pcos randomized clinical trial women pcos randomly allocated two groups receiving green tea tablets placebo period intervention days serum levels interleukin high sensitivity reactive protein tumor necrosis factor measured intervention period using related kits anthropometric indices also measured mean body mass index weight waist circumference body fat percentage green tea group reduced significantly however significant difference observed two groups also significant effect levels inflammatory factors present results suggest daily consumption green tea tablets cause effect inflammation biomarkers pcos women however may effective complementary treatment weight control women copyright john wiley sons ltd
background recently intra articular botulinum toxin bont shown reduce joint pain osteoarthritic dogs similar results reported human patients arthritis however mechanism antinociceptive action bont currently known aim study explore mechanism action investigating effect bont synovial fluid serum substance prostaglandin pge tumor necrosis factor alpha tnf alpha osteoarthritic dogs additionally aim compare pge osteoarthritic non osteoarthritic joints investigate associations pge osteoarthritic pain signalment dogs thirty five dogs chronic naturally occurring osteoarthritis non osteoarthritic control dogs included study osteoarthritic dogs received either bont placebo serum samples collected osteoarthritic pain evaluated baseline weeks treatment osteoarthritic pain assessed force platform helsinki chronic pain index joint palpation synovial fluid samples obtained control dogs euthanasia change baseline pge concentration compared bont placebo groups synovial fluid pge concentration compared osteoarthritic control joints associations pge osteoarthritic pain signalment dogs evaluated results significant change baseline pge bont synovial fluid pge significantly higher osteoarthritic compared control joints synovial fluid pge correlated osteoarthritic pain associations found pge signalment dogs concentration tnf alpha remained detection limit assay samples conclusions results suggest antinociceptive effect bont joint might related inhibition pge synovial fluid pge could marker chronic osteoarthritis pain dogs
background learned associations depressive behavior environmental stimuli signaling low light availability winter season may play role seasonal affective disorder sad purpose study determine whether light season environmental cues elicit emotional responses distinct individuals sad methods twenty four currently depressed sad participants compared demographically matched controls depression history emotional responses outdoor scenes captured two light intensity clear sunny overcast sky three season summer green leaves fall autumn foliage winter bare trees conditions emotion measures included surface facial electromyography emg activity corrugator supercilii zygomaticus major muscle regions skin conductance self reported mood state profile mood states depression dejection subscale results light intensity salient cue season determining emotional reactions among sad participants relative controls sad participants displayed corrugator activity frequent significant skin conductance responses scr greater scr magnitude self reported depressed mood response overcast stimuli less corrugator activity lower scr magnitude less self reported depressed mood response sunny stimuli limitations study limitations include single opposed repeated assessment lack nonseasonal depression group conclusions findings suggest extreme emotional reactivity light relevant stimuli may correlate winter depression future work examine potential onset maintenance significance elsevier rights reserved
objective explore effect depression sleep quality circadian rhythm ambulatory blood pressure patients essential hypertension methods total older patients hypertension screened depression divided two groups pittsburgh sleep quality index psqi circadian rhythm ambulatory blood pressure compared non depressed control depressed case group results case group ambulatory sbp dbp nocturnal sbp dbp higher control group circadian rhythm non dipper higher positive correlation psqi depression conclusion significant correlation sleep quality depression older patients hypertension depression increases circadian rhythm non dipper older patients hypertension elsevier ltd rights reserved
use category race science relation humans remains controversial last years lively debate topic field relatively young neuroscience discipline called cultural neuroscience main focus cultural neuroscience biocultural conditions development different dimensions human perceptive activity cognitive emotional dimensions analysed comparison representatives different social ethnic groups article present arguments supporting two hypotheses race effect understood individual distinct effect exist rather exemplification much broader phenomenon call unfamiliarity homogeneity effect includes problems differentiation recognition faces representatives ethnic groups also covers similar recognitional difficulties recognition members social groups languages even certain sounds objects race based terminology categories used cultural neuroscience research vague inconsistent manner approach distorts science empirically conceptually significant respects unfamiliarity homogeneity effect example situation narrowing race effect makes difficult analyse wider context crucial understanding
biological environmental changes creating growing demand historical global data sets comparing date ecological biological findings historical statements become major part scientific work field ecology evaluation comparison procedure time consuming availability raw data low comparisons original findings available require lot work print publication digitalization transformation appropriate data formats effective use working capacity general issue become important use information technologies invoked minimize time wasting copy paste operations paper aim present working repository terrestrial biological data implementation type data repository provide various services participating scientists long final aim publication repositories furthermore security long term availability environmental data issue increasing importance scientific community unrepeatable sampling events data thus obtained precious time series analysis reason well structured storage data necessary easy accessibility retrieval comparability important issue community environmental scientists need construct implement repositories prevail hitches therefore describing going task primary population kind data repository biological ecological information system matter public interest also key issue ecologists elsevier nipr rights reserved
previous association studies shown mixed results glutamic acid decarboxylase like gadl gene polymorphism prophylactic lithium response bipolar disorder patients present study gadl gene expression investigated regard lithium response using alda scale lyntphoblastoid cells lcls caucasian patients difference gadl expression observed among lcls excellent responders non responders controls furthermore lithium induce significant changes gadl expression levels days results support association gadl expression determination lithium response patients
aim investigate association calcium vitamin vit supplementation bone mineral density bmd pediatric acute lymphoblastic leukemia materials methods group novo patients aged years group pediatric survivors first complete remission patients maintenance chemotherapy stratified group subgroups according postdiagnosis period group iia group iib group iic group iii healthy siblings group daily oral vit carbonate given group group bmd measured diagnosis completion intensive chemotherapy results significant increase vit decrease magnesium detected compared group mean plasma levels vit groups total body total body less head bmd scores decreased significantly compared lowest bmd scores found months diagnosis unsupplemented patients gradual increase bmd scores shown highest scores group iic conclusion vit supplementation pediatric patients intensive chemotherapy may prevent bone mineral loss bmd scores pediatric patients described studies major decrease first years gradual increase afterward also observed patients
recently developing high efficiency photocatalytic hydrogen generation photocatalysts clarifying inherent mechanism behind enhancement hydrogen generation activity research focus present step wise strategy prepare ptitio reduced graphene oxide photocatalysts inherent mechanism enhanced photocatalytic activities systematically investigated experimentally rgo doped rgo tio nanocomposites showed superior solar driven hydrogen generation rate mol times times higher bare tio tio samples respectively ray photoelectron spectroscopy xps fourier transform infrared spectra demonstrated formation bonds hybrid drove shifting upwards valence band edge furthermore pliotoelectrochemical tests indicated electron density ptg one order magnitude higher tio moreover dft calculations displayed bandgap successfully narrowed original blank energy region located tio bandgap filled orbitals resulted excited electrons tio efficiently transferring graphene consequently dft calculations good agreement experimental results physical characterizations study affords rational design high efficiency photocatalytic system solar energy conversion elsevier rights reserved
authors explore concepts knowledge centric organizations performing arts sector means understand specific organizational practices might relate measures financial operational performance employing definition knowledge centric arts organization authors conduct exploratory quantitative study small mid sized non profit performing arts organizations united states using primary data organizational practices secondary data performance metrics analysis two data sources independently suggests gap organizations practices performance statistical analyses using factor analysis linear regression identify seven distinct performance metrics positively associated knowledge centric practices findings serve basis investigation organizations sustainable operate effectively knowledge driven society
virtue adopting core symptomatic fear fear weight gain primary treatment target treatment centrally involves exposure driven processes however exposure trials targeting fear weight gain sparse yielding mixed results date translating extinction theory treatment likely absence clear distinction constitutes core feared cue core feared outcome stymied application exposure treatments review considers several configurations core fear association noting distinct therapeutic strategies may allow precise efforts violating fear based expectancies specific guidance offered clinical decision making process strategies might best promote inhibitory learning clinical case discussed treatment adjusted specifically violate core underlying fear association elsevier ltd rights reserved
background evaluating impact steroid immunosuppressants therapy prior colectomy crohn disease patients postoperative septic colectomy specific outcomes using american college surgeons acs national surgical quality improvement program nsqip targeted colectomy database methods patients undergoing colectomy retrieved nsqip targeted database thirty day postoperative outcomes compared patients steroids immunosuppressants within days prior colectomy others using univariable multivariable analyses results patients patients group younger greater proportion underwent laparoscopic surgery use associated higher rate sepsis anastomotic leak return operating room multivariable analysis associated sepsis septic shock anastomotic leak odds ratio confidence interval conclusions results suggest use within days colectomy associated higher rate sepsis septic shock anastomotic leak patients withholding prior surgery selective use ostomy mitigate consequences leak hence sepsis need due consideration prior surgery
although step literature posits inconsiderate behaviors characterize alcoholics addicts little data support association among adolescent populations using matched pair study design youths ages female minority significant dose response relationship found greater alcohol drug use severity increased likelihood driving influence unprotected sex without history sexually transmitted incidence low volunteerism among boys findings suggest alcohol drug use severity associated poor awareness impact behaviors others
rcs characteristics stealth modified three surface aircraft analyzed paper prototype built catia software three dimensional digital models modified stealth three surface also designed based carrier based aircraft numerical simulation rcs characteristics three surface aircraft conducted rcsansys software based physical optics method method equivalent currents following results obtained comparative analysis mathematical statistics use physical optics method equivalent electromagnetic current method scattering intensity part model rcs characteristic aircraft analyzed efficiently accurately compared model mean rcs value model reduced forward direction lateral direction compared model mean rcs value model decreases forward direction lateral direction results expected provide theoretical basis technical support conceptual design aircraft stealth technology research
objective although people experience traumatic event point life develop significant psychological symptoms aftermath current study use preexisting longitudinal study located long island examine impact hurricane sandy internalizing symptoms large sample children focused temperamental fear biomarker risk anxiety error related negativity ern ern negative deflection event related potential erp occurring individuals make mistakes increased anxious individuals method final sample consisted children undergone observational assessment fear age years electroencephalogram assessment ern age years age year assessment internalizing symptoms assessed hurricane weeks later results significant three way interaction among fearfulness hurricane stressors ern predicting posthurricane increases internalizing symptoms suggested children high fear age years experienced elevated hurricane stressors characterized subsequent increases internalizing symptoms also characterized increased ern age years conclusion findings support diathesis stress model suggesting early temperament prestressor biological markers confer risk increased psychological symptoms following environmental stressors
stream hydraulics control flux slow moving water transient storage wts zones thus hydrologic retention stream channels stream nutrient uptake thought depend hydrologic retention stream hydraulics could influence extent stream nutrient biogeochemistry affects nutrient export downstream goals characterize wts emphasis water residence time evaluate influence nutrient uptake analyzed data monthly solute tracer injections accompanying nutrient uptake estimates hydrogeomorphically different streams fit conservative tracer breakthrough curves hydrodynamic models one dimensional transport inflow storage otis stochastic mobile immobile model smim allows wide distribution water residence times streams differed hydraulically especially water residence time distributions wts zones smim parameters depended less discharge otis parameters indicating smim may influenced local features channel morphology hydrologic conditions uptake differed streams correlated smim hydraulic parameters weakly correlated otis parameter based smim correlations parameters related exchange free flowing water water storage zones stream retention times explained respectively variation uptake streams soluble reactive srp uptake similar streams correlated hydraulic parameters results indicate hydraulics residence time water important regulators wts zones nutrient uptake headwater streams environmental factors must considered complete understanding stream nutrient processing capacity
paper presents latest research development international construction project icp domain revealed construction management related journals systematic document retrieval method employed collect relevant articles identified papers analyzed using bibliometric analysis comprising investigation number publication main originators research contributions affiliations cited papers sources research funding well research methods used ninety eight relevant articles obtained major journals associated construction management studies successfully assessed results show upward trend fluctuations period bibliometric information icp studies successfully presented
new second order accurate hybrid incremental projection method time dependent incompressible viscous flow introduced paper hybrid finite element finite volume discretization circumvents well known ladyzhenskaya babuska brezzi conditions stability require special treatment filter pressure modes either rhie chow interpolation using petrov galerkin finite element formulation use velocity high resolution advection method linearly consistent edge based treatment viscous diffusive terms yields robust algorithm broad spectrum incompressible flows high resolution advection method shown deliver second order spatial convergence mixed element topology meshes implicit advective treatment significantly increases stable time step size algorithm robust extensible permitting incorporation features porous media flow rans les turbulence models semi fully implicit time stepping series verification validation problems used illustrate convergence properties algorithm temporal stability properties demonstrated range problems cfl new flow solver built using hydra multiphysics toolkit hydra toolkit written provides rich suite extensible fully parallel components permit rapid application development supports multiple discretization techniques provides interfaces dynamic run time load balancing data migration interfaces scalable popular linear solvers open source packages hypre petsc trilinos elsevier inc rights reserved
new treatment approaches needed patients severe composite mental disorders resistant conventional treatments treatment resistant patients often diagnoses psychotic bipolar disorders severe personality disorders comorbid conditions study evaluate basal exposure therapy bet novel ward integrated psychotherapeutic approach patients central bet conceptualization undifferentiated existential fear basic patients problem exposure fear therapeutic platform complementary external regulation integrates governs totality interventions throughout treatment process bet administered locked door ward patient beds full time employees including psychiatrist psychologists thirty eight patients completed bet included two female mean age years fourteen patients diagnosis schizophrenia schizoaffective disorder eight bipolar disorder recurrent depressive disorder eight diagnoses domain neurotic stress related somatoform disorders five diagnosed emotionally unstable personality disorder three patients diagnoses twenty patients one icd diagnosis average treatment time bet months ranging months time series data show significant improvements symptoms functioning enrollment discharge effect sizes dissociation experience scale brief symptom inventory avoidance action questionnaire respectively functioning symptom subscales global assessment functioning scale addition patients used significantly less antiepileptic antipsychotic anxiolytic antidepressant medications discharge treatment enrollment patient improvement across treatment associated following duration time bet successful completions exposure component bet positive changes experiential avoidance measured acceptance action questionnaire high symptom levels low levels functioning treatment start findings indicate bet may promising inpatient psychotherapeutic approach previously treatment resistant patients severe comorbid conditions
paper presents system architecture expected link availability sirius satellite radio system contiguous united states conus canada service regions sirius delivers channels talk music subscribers conus service available different markets vehicles homes portables marine aviation offered subscription basis descriptions performance sirius system detailed herein copyright john wiley sons ltd
background aims oral regimens associated high cure rates hepatitis virus genotype hcv patients aim assess value cure society treating hcv infection methods markov model hcv projected long term health outcomes life years quality adjusted life years qalys gained model compared second generation triple sofosbuvir pegylated interferon ribavirin simeprevir oral ledipasvir sofosbuvir ombitasvir paritaprevir ritonavir dasabuvir ribavirin therapies treatment sustained virological response rates based phase iii rcts assumed hcv patients eligible second generation triple oral regimens transition probabilities utility mortality based literature review value cure calculated difference savings economic gains associated additional qalys results model estimated million treatment naive hcv patients treating eligible hcv patients second generation triple oral therapies resulted million million additional qalys gained compared treatment respectively using value qaly regimens lead savings billion billion costs regimens billion billion value cure second generation triple oral regimens billion billion conservatively assumed drug costs cost savings greater hcv patient cured cirrhosis compared patients without cirrhosis conclusions recent evolution regimens hcv increased efficacy value cure
psoriasis chronic autoimmune inflammatory disorder impacts skin joints propensity produce devastating psychosocial economic occupational effects often solitary example psychological manifestations may impact one occupational economic statuses purpose reviewis raise awareness consequences disease clinicians may consider incorporating patient centered model care
background antibiotics oral contraceptive pills ocps found effective managing acne vulgaris despite widespread use direct comparisons efficacy modalities published objective compared efficacy antibiotics ocps managing acne methods meta analysis conducted accordance preferred reporting items systematic reviews meta analyses cochrane collaboration guidelines results review publications yielded randomized controlled trials met inclusion criteria months compared placebo antibiotics ocps effected greater percent reduction inflammatory noninflammatory total lesions modalities time point demonstrated statistical parity except antibiotics superior ocps percent reduction total lesions months weighted mean inflammatory lesion reduction month course oral antibiotic treatment month course ocps month course placebo treatment month course oral antibiotic treatment month course ocps month course placebo treatment weighted mean noninflammatory lesion reduction month course oral antibiotic treatment month course ocps month course placebo treatment month course oral antibiotic treatment month course ocps month course placebo treatment weighted mean total lesion reduction month course oral antibiotic treatment month course ocps month course placebo treatment month course oral antibiotic treatment month course ocps month course placebo treatment limitations investigative treatment heterogeneity publication bias limitations conclusions although antibiotics may superior months ocps equivalent antibiotics months reducing acne lesions thus may better first line alternative systemic antibiotics long term acne management women
study measured cerebellar volume normal male adults magnetic resonance imaging mri analysed relationship cerebellar volume various psychological parameters cerebellar volume males mean age years measured using mri symptom checklist scl component type behavior tests performed using linear regression analysis relationship cerebellar volume psychological parameters analysed phobic anxiety ambition increased cerebellar volume normal male subjects decreased study showed even normal male adults exists possible relationship various psychological parameters cerebellar volume authors published elsevier ltd
plant irradiation germination period using environmental low level microwave radiation known electrosmog alters plant germination growing process order analyze subtle effect generated microwave irradiation environmental parameters light temperature humidity must kept identical reference irradiated lot difficult task humidity temperature interrelated order study plant behavior microwaves low power irradiation paper describes design manufacturing operating process device performances plant growth end low power microwave field average microwaves power density controlled environmental parameters used device consists reference chamber microwave irradiation chamber volume one equipped access doors irradiation chamber ensures microwave field distribution programmable power frequency bandwidth commonly used standards network communication global system mobile communications gsm code division multiple access cdma third generation mobile telecommunications technology ghz wireless local area network wlan chambers provide radiofrequency shielding least toward outside electrosmog shielded interfere inner environment chambers equipped performing temperature humidity sensors controlled led lighting system maximum mol uniformity mol measured bottom level chamber embedded system microcontroller measures temperature humidity proceeds continuously match humidity chambers pair less relative humidity difference using low flux exhaust ventilation process simple innovative method accuracy temperature measurement better degrees humidity temperature data set logged programmable acquisition rate whole experiment read later personal computer identify influence microwave treatment bean seeds plants development three growing experiments settled based bean seeds number germinated seeds determined day days experiment germination energy seeds length stems roots germination seedling vigor index svi dry matter content measured computed obtained data showed significant increase parameters microwave irradiation condition elsevier rights reserved
background alcohol use disorder aud among prevalent mental disorders worldwide associated diverse range physical psychological comorbidities despite various types treatment many barriers accessing treatment stigma cost accessibility service etc mobile apps potential overcome barriers provide support need objective purpose systematic review assess effectiveness mobile apps reducing alcohol consumption individuals aud understand psychological outcomes using apps client empowerment self efficacy etc methods search strategy applied health sciences interdisciplinary databases two reviewers independently assess titles abstracts relevance full texts relevant articles eligibility included article must quantitative evaluation clinical outcomes using intervention intervention must consumer facing app focused supporting individuals aud two reviewers independently extract data eligible articles using standardized extraction worksheet independently assess study quality meta analysis conducted appropriate depending outcomes reported pooled risk ratios standardized mean differences calculated reported review results search strategy yielded unique citations articles assessed relevant full text review full text reviews currently underway final review projected completed summer conclusions potential mobile apps support individuals aud reduce alcohol consumption review first assess effectiveness aud mobile apps client experiences using apps
interpersonal coordination extent social partners coordinate postures mannerisms acts social glue serves individual social goals producing prosocial behaviors facilitating harmonious interactions research area become prominent variety domains within outside psychology forming sizeable literature dedicated investigating causes consequences interpersonal coordination conducted series meta analyses studies treated interpersonal coordination independent variable order measure effect several intrapersonal mood need belong interpersonal prosocial behavior outcomes well several potential moderators percentage female participants may affect strength effect overall results demonstrated positive effects interpersonal coordination robust exceptions specific intrapersonal outcomes findings provide much needed quantitative summary literature interpersonal coordination highlight areas merit future research
spatial statistics provides useful methods incorporating spatial dependence land cover classification however geometric features land cover classes difficult captured geostatistical models due smoothing effect objective study incorporate spectral similarity markov chain random field mcrf cosimulation comcrf model propose spectral similarity enhanced mcrf cosimulation comcrf model land cover postclassification postclassification cause less geometric loss two mutually complementary spectral similarity measures jaccard index spectral correlation measure employed constraining factor comcrf one medium spatial resolution scene complex landscape one high spatial resolution scene urban landscape selected case studies neural network classifier support vector machine classifier used conduct land cover preclassifications comcrf comcrf used postprocess preclassified images based expert interpreted sample datasets multiple data sources compared preclassified results depend spectral information pixels postclassifications models achieved similar significant improvements overall accuracy however compared comcrf comcrf model apparently improved postclassified land cover patterns effectively capturing geometric features boundaries linear stripes details land cover classes general incorporating spectral similarity land cover postclassification sscomcrf may contribute significantly shape geometric accuracy classified land cover classes
paper presents gait generation navigation algorithms autonomous self reconfiguring mobile robot platform chaser capable changing configuration according surroundings robot attains selftransforming capability due multiple degrees freedom structure board range sensing ability proposed gait generation navigation algorithms enable chaser reconfigure shape best suited pass obstacles presented moreover robot capability traverse various type terrains moving wheels walking like quadruple swimming like humans respectively multiple kinds gaits coupled terrain navigation algorithm robot could identify different kinds terrains obstacles transform navigate seamlessly performance chaser experientially tested various real world obstacles experimental results validate performance
immunotherapy entirely advanced class cancer treatment highly active exciting field clinical therapeutics numerous procedures cancer immunotherapy demands laborious practice recognise count dendritic cells dcs vaccine preparation conventionally laser based technology provides rapid analysis flow cytometry affect dcs viability staining procedure involved another highly promising method phase contrast microscopy pcm involves experienced pathologists visually examine respective microscopy images facts pcm confronts complex issues regarding imaging artifacts deteriorate recognition process dcs counting crucial cancer treatment procedures paper proposes pioneering system called casdc implement image processing algorithm recognise count dcs label free method aim developing system establish reliable time saving tool second reader clinical practice meantime treatment procedure administered therefore improve patient survival rate proposed system enormous potential towards helping cancer research institute system offers rapid high throughput cancer immunotherapy vaccine preparation automated live cell investigation authors published elsevier
clinical decisions sometimes based variety patient information age weight information extracted image exams among others depending nature disease anatomy clinicians base decisions different image exams like mammographies positron emission tomography scans magnetic resonance images however analysis exams far trivial task years use image descriptors computational algorithms present summarized description image regions became important tool assist clinician tasks paper presents overview use image descriptors healthcare contexts attending different image exams making review analyzed studies related application image descriptors different natures intensity texture shape medical image analysis four imaging modalities featured mammography pet mri pathologies typically covered modalities addressed breast masses microcalcifications mammograms head neck cancer alzheimer disease case pet images lung nodules regarding cts multiple sclerosis brain tumors mri section
high resolution sigma delta analog digital converters sdadc drastically changed traditional analog signal processing stages however boundary analog digital worlds becomes diffuse mixed signal processing approach arises instance analog filters traditionally implemented independent processing stages easily incorporated design sigma delta converter resulting compact approach important advantages regarding size power consumption context design technique mixed signals front ends intended biomedical signals presented example design ecg front end presented accepts offsets presents input range bandwidth total noise less operating clock frequency khz front end provides fast baseline recovery features transient response fulfills aami standard functional prototype built tested validating design procedure
background although small elevations high sensitive cardiac troponin ctnt associated incident heart failure general population underlying mechanisms well defined evaluating association ctnt replacement fibrosis progression structural heart disease symptoms fundamental understanding potential biomarker prevention strategy methods measured ctnt baseline among participants mesa multi ethnic study atherosclerosis cohort initially free overt cardiovascular disease cvd cardiac magnetic resonance imaging performed baseline repeat cardiac magnetic resonance performed years later among participants remained free interim cvd events received gadolinium enhanced cardiac magnetic resonance characterization replacement fibrosis late gadolinium enhancement progression subclinical cvd defined year change left ventricular structure function associations ctnt incident related mortality coronary heart disease estimated using cox regression models results late gadolinium enhancement replacement fibrosis detectable participants without interim cvd events follow cardiac magnetic resonance graded association observed higher baseline ctnt categories late gadolinium enhancement versus limit detection highest category versus versus limit detection adjusted hazards ratio conclusions ctnt levels associated replacement fibrosis progressive changes left ventricular structure cvd free adults findings may precede symptoms years minor elevations ctnt may represent biochemical signature early subclinical cardiac disease providing opportunity targeted preventive interventions
animal models cuprizone bis cyclohexanone oxaldihydrazone feeding helpful study experimental demyelination remyelination context diseases like multiple sclerosis cuprizone copper chelator supplemented normal food cbl mice concentration leads oligodendroglial loss subsequent microglia astrocyte activation resulting demyelination termination cuprizone diet results remyelination promoted newly formed mature oligodendrocytes exact mode cuprizone action well understood information inactivation cleavage still available knowledge processes could lead better understanding cuprizone mode action well safer handling toxin therefore performed experiments aim inactivate cuprizone thermal heating since suggested past cuprizone heat sensitive cbl mice fed weeks cuprizone either thermally pretreated degrees heated addition primary rat oligodendrocytes known selective toxic target cuprizone incubated cuprizone solutions either thermally pretreated results demonstrate none tested thermal pretreatment conditions could abrogate restrict toxic demyelinating effects cuprizone neither vitro vivo conclusion current study rebuts hypothesis cuprizone heat sensitive compound well assumption heat exposure reason insufficient demyelination cuprizone containing pellets
one anthrax receptors tumor endothelial marker tem reported potential anticancer target due expression tumor angiogenesis extend biolayer interferometry study tem binding present computational approach reveal role integral metal ion receptor structure binding thermodynamics estimated interaction energy tem using computer simulation consistent experimental study computational results indicate metal ion tem contributes significantly binding affinity tem binding favorable presence computational analysis suggests differences tem binding affinity comparable closely related integrin proteins conformation change linked changes activity integrins found tem present tem remains conformation analogous integrin open high affinity conformation wiley periodicals inc
context therapeutic effects alpha guluronic acid greatest tolerability efficacy shown experimental model multiple sclerosis vitro vivo examinations regarding alpha guluronic acid toxicological researches safety although pharmacological impacts recorded objective study designed determine acute sub chronic toxicity alpha guluronic acid healthy male female balb mice materials methods acute toxicity study animals orally received five different single doses alpha guluronic acid kept observation sub chronic study male female balb mice divided four groups treated daily test substance preparation dose levels body weight least consecutive days mortality body weight changes clinical signs hematological biochemical parameters gross findings histopathological organs weight determinants monitored study results results acute toxicity indicated alpha guluronic acid found mortality abnormality clinical signs body weight relative organs weight necropsy animals subchronic study additionally results showed significant difference hematological biochemical histopathological parameters rats conclusions results suggest alpha guluronic acid high safety administered orally animals
hip fractures prevalent involve high morbidity mortality improving management important registries good way improve knowledge condition quality care time reducing clinical variability optimizing efficiency improving outcomes reducing costs hip fractures prevalent fragility fracture secondary osteoporosis involves high morbidity mortality low impact fractures resulting fall standing sitting height despite numerous clinical practice guidelines establish uniform recommendations care great variability persists regarding clinical healthcare outcomes fracture registries help detect deficits establish measures improve care objective work analyze contents registry compare characteristics national registries literature search conducted several national hip fracture registries contain relevant information variables outcomes selected selected registries compared using parameters measure well outcomes different countries variables collected majority databases give useful information follows sociodemographic variables age sex place residence clinical variables function anesthesia risk measured asa score type fracture type surgery anesthesia hospital month mortality healthcare variables pre operative overall stay presence collaboration orthogeriatrics clinician addition surgeon secondary prevention new fractures assessing fall risk need osteoporosis treatment recording cases different countries improves knowledge handling condition quality care time reducing clinical variability optimizing efficiency improving outcomes reducing costs debate variables recorded timely organizing collect measurement even trying unify national international registries using current proposal one fragility fracture network
background approximately rural nigerian households rely biomass fuels cooking international study asthma allergies childhood isaac estimates prevalence current wheeze among children nigeria risen approximately objective examine effects biomass smoke exposure asthma symptom prevalence rural children nigeria methods conducted cross sectional survey rural communities nigeria asthma symptoms defined according isaac definitions biomass smoke exposure determined types fuel used cooking logistic regression used explore associations biomass smoke asthma symptoms results study population comprised school children lived households cooking biomass lived households using biomass asthma symptoms reported children biomass fuel associated increased odds asthma symptoms adjusted odds ratios aors nocturnal cough current wheeze report asthma related symptoms sex modified associations asthma symptoms biomass fuel aors stronger significant males nocturnal cough current wheeze report asthma related symptoms weaker non significant females conclusion risk asthma symptoms related biomass smoke exposure appears differ sex
extreme sports canyoneering expanded greatly since turn century yet little scientific attention paid analyses dangers activities author much involved promoting one sport namely canyoneering presents paper example kind fluids engineering analyses needed order objectively quantify dangers properly advise participants canyoneering primary fluid related sources danger impact falling water human body dangers swimmer faces plunge pool paper presents rough evaluations dangers
primary aim research assess level trace elements electrolytes serum postmenopausal diabetic women sixty four postmenopausal women type diabetes mellitus age body mass index matched controls examined serum trace elements assessed using inductively coupled plasma dynamic reaction cell mass spectrometry icp drc fasting plasma glucose fpg glycated hemoglobin hba levels evaluated using randox kits obtained data demonstrate patients characterized higher fpg hba levels respectively level diabetic postmenopausal women increased comparison respective control values serum concentrations lower control ones respectively fpg hba levels directly correlated serum concentrations inversely related levels multiple regression analysis demonstrated significant association serum fpg hba levels proposed play important role pathogenesis studies required assess intimate mechanisms observed differences
pediatricians working emergency environment confronted children admitted emergency departments intoxication daily basis carried retrospective cohort study children admitted pediatric emergency department due unintentional cannabis exposure year period twenty nine children age admitted positive cannabis urine test eighty seven percent intoxications occurred family home resin main form ingested cannabis mean age months mean weight sixty percent admissions occurred severe presentations based poisoning severity score occurred past years four children experienced seizures admission ten children decreased level consciousness gcs admitted pediatric intensive care unit ingested hashish resin majority children suffering neurological impairment admitted last year three required assisted ventilation cases major outcomes deaths parents assessed regarding cannabis consumption conclusion study supports impression accidental child poisonings cannabis serious previously thought years observation may explained increased thc concentration cannabis widespread use young adults even become parents introducing addiction team inside ped could help improve care links parents
flow concentric annular passage rotating inner cylinder called taylor couette flow important industrial applications electric motor requires effective cooling rotating shaft also saving power required axis rotation flow superposed called taylor couette poiseuille flow affects cooling efficiency torque required axis rotation authors knowledge previous studies focused either nusselt number torque coefficient taylor couette poiseuille flow therefore difficult estimate flow effects geometry flow conditions study flow effects nusselt number torque coefficient taylor couette poiseuille flow geometry flow conditions investigated performing large eddy simulation flow reynolds number varied constant taylor prandtl numbers respectively nusselt number torque coefficient similar trend increase decreased change nearly constant change contribution advection turbulent transport diffusion terms nusselt number torque coefficient evaluated using equations proposed authors contribution advection term nearly zero contrary case without flow increased contribution turbulent transport term decreased diffusion term change much friction factor axial direction varied power laminar turbulent correlations smooth stationary pipe flow
background cryptococcus neoformans etiologic agent opportunistic systemic fungal infection cryptococcosis affects individuals compromised immune systems thus natural products research become important since monoterpenes carvacrol promising molecule search antifungal agents shown significant biological activity objective study aimed investigate antifungal activity mode action carvacrol strains neoformans methods minimum inhibitory concentration mic determined microdilution method minimum fungicidal concentration mfc performed seeding technique solid media studying mode action performed using broth microdilution results mic ranged mfc ranged carvacrol bonded exogenous ergosterol cholesterol discussion results suggest carvacrol antifungal activity neoformans mode action related fungal membrane instability conclusions phytoconstituent carvacrol may eventually become drug however studies needed elucidate mechanism
byte addressable non volatile memory nvram likely supplement perhaps eventually replace dram applications persist data structures directly memory instead serializing storing onto durable block device however failures execution leave data structures nvram unreachable corrupt paper present makalu system addresses non volatile memory management makalu offers integrated allocator recovery time garbage collector maintains internal consistency avoids nvram memory leaks efficient face failures show careful allocator design support less restrictive much familiar programming model existing persistent memory allocators allocator significantly reduces per allocation persistence overhead lazily persisting non essential metadata employing post failure recovery time garbage collector experimental results show resulting online speed scalability allocator comparable well known transient allocators significantly better state art persistent allocators
context increased activities arginine vasopressin avp system hypothalamic pituitary adrenal hpa axis shown associated human obesity relationships systems obesity remain unclear objectives assess hpa axis responsiveness relation serum concentrations avp surrogate copeptin subjects obesity comparison non obesity controls noc methods cross sectional monocentric study thirty nine age years body mass index bmi compared twenty two noc age years bmi matched age sex individuals underwent combined dexamethasone crh test main outcome measures plasma acth cortisol curve indicators derived dex crh test post crh concentrations min crh maximum concentration max area curve auc acth cortisol ratios copeptin assessed samples dex crh test oral dexamethasone prior crh administration results copeptin serum concentrations higher median iqr noc pmol correspondingly showed higher post crh cortisol concentrations noc nmol lower post crh acth cortisol ratio noc pmol nmol serum copeptin significantly associated hpa responsiveness post crh acth driven men post crh acth post crh cortisol associations withstand adjustments bmi age conclusions association increased copeptin acth cortisol release suggests potential mechanistic interaction avp system hpa activation human obesity relation copeptin hpa responsiveness validated situations pronounced hpa activation depression multiple sclerosis elsevier ltd rights reserved
platelet storage pool disease spd platelet function disorder characterized reduction number content dense granules reports spd mostly limited case presentations aimed retrospectively describe series patients spd better characterize disease studied patients congenital acquired spd lumiaggregometry granules content platelet ultrastructure iib integrin glycoprotein gpib activation assessed patients generally demonstrate mild moderate bleeding diathesis platelet aggregation studies showed moderate abnormalities variable profiles individuals almost complete absence adenosine triphosphate release mepacrine capture expression study dense granules electron microscopy enabled distinguish different subtypes spd quantitative qualitative defect surprisingly significantly decreased gpib expression levels platelet activation thrombin receptor activating peptide found suggesting gpib impaired mobilization may represent additional feature disorder conclusion spd represents complex disorder various clinical biological aspects requiring great deal expertise properly diagnosed
retrospective audit patients diagnosed mature cell lymphoma across year period provides contemporary information outcomes treatment patterns australian cohort forty two patients diagnosed mature cell lymphoma identified tasmanian cancer registry analysed using medical records simple statistical analysis demographics outcomes patients cohort comparable large international studies treatment patterns line best available evidence
paper three party controlled quantum secure direct communication authentication qsdca protocol proposed using four particle cluster states via quantum one time pad local unitary operations present scheme permission controller sender receiver implement secure direct communication successfully circumstances charlie obtain secret message eavesdropping detection identity authentication achieved help previously shared reusable base identity strings users protocol unconditionally secure ideal practical noisy cases one transmission qubit four particle cluster state used controller permission qubit another qubit used recover two classical bits information proposed scheme effciency improved compared previous works
tree fruit crop production amelioration planting biological agents still contentious topic organic material incorporated soil planting damage tree root system applied top soil contribution soil biology questionable indeed reported various authors nevertheless need improve soil biology maintain high yields sustainable ever increasing chemical fertilizer application approach need achieve without major physical interference root zone research aimed investigating possible effects biological inorganic mulch top soil established cripps pink apple orchard sandy loam soil woven black poly geotextile chosen inorganic mulch control received mulch rest treatments comprised wood chips compost thin wood chip layer top thin vermi compost application standard orchard practices fertilization irrigation pest management followed main emphasis quantify effects soil biology soil environment root distribution nutrient uptake distribution especially fruit improve fruit quality soil environment quantified terms micro macro elements soil temperature wood chips increased whereas vermi compost increased mulches changed minimum temperature top degrees much degrees maximum temperature summer destructive root study showed roots diameter less comprised bulk average total root volume treatments top also contained highest percentage roots smaller mycorrhiza studies indicate significant increase colonization control mulches sandy loam site preliminary nematode results showed organic mulches decreased percentage pathogenic nematodes
article two different state space models distributed solar collector field extracted design iterative extended kalman filter iekf appropriate controller distributed solar collector field simulations purposes study feed forward controller moreover pid controller used designed controller order attenuate disturbances effects caused solar radiation inlet oil temperature environmental temperature models used estimate distributed solar collector field temperature profile shown temperature parts solar collector field inlet oil temperature estimated using models iterative extended kalman filter iekf use one sensor measure temperature along collectors also exposed used kalman filter could greatly eliminate applied noises system thus makes system robust influencing noises sensors errors required parameters implementation iterative extended kalman filter controller simulation extracted shiraz solar power plant elsevier ltd rights reserved
golgi apparatus central organelle secretory pathway involved post translational modification sorting lipids proteins mammalian cells golgi apparatus composed stacks cisternae organized polarized manner interconnected membrane tubules constitute golgi ribbon located proximity centrosome besides processing transport cargo golgi complex actively involved regulation mitotic entry cytoskeleton organization dynamics calcium homeostasis apoptosis representing signalling platform control several cellular functions including signalling initiated receptors located plasma membrane alterations conventional golgi organization associated many disorders cancer different neurodegenerative diseases review examine functional implications modifications golgi structure neurodegenerative disorders focus role golgi fragmentation development alzheimer disease comprehension mechanism induces golgi fragmentation downstream effects neuronal function potential contribute development effective therapies treat prevent disorders elsevier ltd rights reserved
lactation may protect women previous gestational diabetes mellitus gdm developing type diabetes mellitus results existing studies inconsistent ranging null beneficial aimed conduct systematic review gather available evidence databases medline cinahl pubmed embase searched december without restriction language publication year manual search also conducted included observational studies cross sectional case control cohort study information lactation type diabetes mellitus incidence among women previous gdm excluded case studies without control data data synthesis conducted random effect meta analysis fourteen reports studies included overall risk bias using robans ranged low unclear longer lactation weeks postpartum risk reduction type diabetes mellitus compared shorter lactation type diabetes mellitus evaluation timey respectively exclusive lactation weeks postpartum also lower risk type diabetes mellitus compared exclusive formula findings support evidence longer exclusive lactation may beneficial type diabetes mellitus prevention women previous gdm however evidence relies observational studies therefore studies required address true causal effect
great success second generation wireless telephone technology third generation mobile telecommunications technology fast development fourth generation mobile telecommunications technology phase fifth generation mobile networks fifth generation wireless systems coming article indicate open research issues security trust context virtualized networking software defined networking propose framework security trust focusing solving network security issues proposed framework applies adaptive trust evaluation management technologies sustainable trusted computing technologies ensure computing platform trust achieve software defined network security adopts cloud computing securely deploy various trustworthy security services virtualized networks analyze framework support satisfy security requirements specified standardization also suggest future research work according proposed framework discuss advantages framework terms practical deployment copyright john wiley sons ltd
background objectives asthma chronic inflammatory disorder requiring intermittent continuous anti inflammatory therapy patients often turn alternative treatments complements replacements conventional treatments aimed evaluate effect salt room chambers halotherapy bronchial hyper responsiveness bhr fractional exhaled nitric oxide feno quality life children asthma patients methods children aged years clinical diagnosis mild asthma receiving anti inflammatory therapy patients randomized double blind controlled study salt room halogenerator treatment group without halogenerator control group evaluated effect salt room therapy bhr feno spirometry pediatric asthma quality life questionnaire paqlq treatment period lasted weeks sessions results twenty nine patients randomized salt room halogenerator treatment group patients salt room without salt halogenerator control group statistically significant improvement bhr demonstrated treatment group remained unchanged control group improvement spirometry feno levels following treatment treatment group showed statistical improvement parameters quality life questionnaires conclusions pilot study suggests salt room halogenerator may beneficial effects mild asthmatic children randomized larger controlled trials long term follow necessary wiley periodicals inc
background early diagnosis idiopathic pulmonary fibrosis ipf become increasingly important due evolving treatment options ipf patients experience significant delay receiving accurate diagnosis thus delayed access tertiary care associated higher mortality independently disease severity objective aims evaluate whether delay referral process determine whether referring doctors suspected ipf interstitial lung disease ild already time referral methods ninety five referral letters patients ipf identified finnishipf registry evaluated respect time referral referring unit grounds referral symptoms smoking status occupational history clinical examinations morbidities medication radiological findings lung function results fifty nine percent referral letters originated primary public health care time symptom onset referral reported cases mean time years main reason referral suspicion interstitial lung disease ild changes chest ray one reason referring cases lung auscultation reported inspiratory crackles referral letters conclusions primary care doctors suspected lung fibrosis early course disease lung auscultation chest rays common investigational abnormalities referrals providing general practitioners information ilds might shorten delay symptom onset referral
generally rainwater harvesting systems used strategy management runoff water supply rainfall transforming rainfall form evaporation flooding collected used help storage methods many restrictions implementation rainwater harvesting systems lack space cost installing systems caused optimization inevitable imperialist competitive algorithm ica new method optimization uses social phenomenon appropriate performance paper multi objective imperialist competitive algorithm moica studied part tehran city iran results showed high effectiveness optimal volume rainwater harvesting systems peak discharge flood volume flood return period years peak flow reduced percent flood volume reduced percent
distributed generation brought new challenges protection engineers since standard relay settings traditional system may longer function correctly new conditions extreme case coordination loss primary backup relays directional overcurrent relay docr implemented protection device electrical network also suffers performance degradation presence therefore paper proposes mitigation impact docr coordination employing adaptive protection scheme aps using differential evolution algorithm impacts prior application aps presented new mitigation scheme proposed
aim guideline provide standards recommendation performance interpretation reporting psma pet prostate cancer imaging recommendations help improve accuracy precision repeatability psma pet prostate cancer essentially needed implementation modality science routine clinical practice
order explore optimal relationship eccentricity mud cement density difference cement displacement process flow characteristics non newtonian fluids involved laminar displacement inside eccentric annulus analyzed fluid mechanics theory optimal density difference criterion established based herschel bulkley fluid model used theoretically determine optimum density difference yielding optimal cement displacement performance numerical simulations performed cfd software investigate influence mud cement density difference displacement performance different eccentricities highly deviated wells results indicate optimal density difference provide best displacement efficiency given inclination eccentricity laminar flow conditions good agreement optimal density differences calculated optimal density difference formula cfd numerical simulations confirms validity optimal density difference criterion determining optimal density difference highly deviated wells research results provide practical guide design cement slurry density install centralizers highly deviated wells laminar flow conditions elsevier rights reserved
objective evaluate cutaneous allodynia among patients chronic episodic migraine tertiary headache clinic methods subjects episodic migraine chronic migraine assessed tertiary hospital item allodynia symptom checklist brazil questionnaire applied classify subjects according presence severity cutaneous allodynia results cutaneous allodynia identified episodic migraine group chronic migraine group increased association could attributed chronic migraine adjusted years disease groups also differ severity allodynia severe presentation frequent discussion groups seemed similarly affected cephalic extracephalic regions severity conclusion cutaneous allodynia frequent chronic migraine presence severity seems associated duration disease
study question effect maternal exposure perfluorooctane sulfonate pfos perflurooctanoic add pfoa perfluorohexane sulfonate pfhxs female fecundity summary answer increasing concentrations pfoa pfhxs maternal plasma associated reduced fecundability infertility known already perfluorinated chemicals pfcs group synthetic compounds used industrial production concern effect pfcs fecundity measured time pregnancy ttp although recent studies suggest increasing concentrations pfcs may decrease fecundity divergence methodological approaches used evaluate association prevented firm conclusions reached study design size duration maternal infant research environmental chemicals mirec study cohort study women recruited weeks gestation cities across canada participants materials setting methods questionnaire administered medical chart data biospecimens collected participants excluding women withdrew data incomplete whose pregnancies followed birth control failure accounting male fertility participants remained tip defined number months unprotected intercourse needed become pregnant current pregnancy self reported first trimester pregnancy plasma concentrations pfoa pfos pfhxs measured first trimester considered surrogate preconception exposure fecundability odds ratios fors estimated using cox proportional hazard models discrete time denote shorter ttp odds infertility ttp months infertility treatment index pregnancy estimated using logistic regression chemical concentration log transformed divided main results role chance cumulative probabilities pregnancy months confidence interval respectively mean maternal age years geometric means pfoa pfos pfhxs respectively adjustment potential confounders pfoa pfhxs associated reduction fecundability per one increase pfoa pfhxs significant association observed pfos addition odds infertility increased per one increase pfoa odds ratio per one increase pfhxs significant association observed pfos limitations reasons caution women highest concentrations pfcs might excluded study causal association infertility mirec study assess concentrations pfcs males semen quality menstrual cycle characteristics intercourse frequency wider implications findings results add evidence exposure pfoa pfhxs even lower levels previously reported may reduce fecundability
purpose review review critically evaluates recent claims infants innate knowledge morality examines sources moral norms recent findings many studies show toddlers readily help adults daily tasks contentious set studies suggests young infants prefer actors help others hinder researchers interpreted findings indicating morality innately present humans others look alternative explanations developmental systems theory summary explaining emergence morality innate wholly socialized problematic instead morality could emerge developmental system children early capacities shaped interpersonal engagement children improving ability coordinate others practical level later transformed language reflective thought children gain ability talk previously implicit interaction throughout parents caregivers many opportunities foster children moral development daily interactions
children born congenital heart malformations clinical animal studies suggest abnormal blood flow forces might play role causing malformation highlighting importance understanding fetal cardiovascular fluid mechanics performed computational fluid dynamics simulations right ventricles based four dimensional ultrasound scans three old normal human fetuses characterize flow energy dynamics peak intraventricular pressure gradients found mmhg systole mmhg diastole diastolic wall shear stresses found around could elevate systole outflow tract fetal right ventricles complex flow patterns featuring two interacting diastolic vortex rings formed diastolic wave wave rings persisted end systole elevated wall shear stresses proximity observed conserve similar peak diastolic kinetic energy carried subsequent systole however carried kinetic energy significantly alter work done heart ejection thus diastolic vortexes played significant role determining spatial patterns magnitudes diastolic wall shear stresses significant influence systolic ejection results serve baseline future comparison diseased hearts
work evaluates potential rainwater harvesting household level dry climate saudi arabia amounts rainwater harvested several cities saudi arabia estimated found significant volume exceeding per year harvested per cubic meter cost harvesting rainwater compared producing desalinated water found harvested rainwater cheaper capture desalinated water produced renewable energy driven desalination plants case fossil fuel powered desalination study also considered effects rainwater harvesting mitigating floods reducing greenhouse gas emissions cost benefit analysis installing rooftop rainwater harvesting systems saudi arabia performed revealed economically feasible harvest rain cities including hail jeddah taif riyadh recommended holy cities makkah medina buraidah
optical absorbers find uses wide array applications across electromagnetic spectrum including photovoltaic photochemical cells photodetectors optical filters stealth technology thermal light sources recent efforts sought reduce footprint optical absorbers conventionally based graded structures fabry perot type cavities using emerging concepts plasmonics metamaterials metasurfaces unfortunately new absorber designs require patterning subwavelength length scales therefore impractical many large scale optical optoelectronic devices article summarize recent progress development optical absorbers based lossy films thicknesses significantly smaller incident optical wavelength structures small footprint require nanoscale patterning outline theoretical foundation absorbers based ultra thin film interference including concepts loss induced phase shifts critical coupling review several applications including ultra thin color coatings decorative photovoltaics high efficiency photochemical cells infrared scene generators
investigation paper set dimensional coupled nonlinear schrodinger equations describes propagation optical beam inside dimensional graded index waveguide polarization effects employing hirota method symbolic computation obtain dark one two soliton solutions variable coefficient constraints backlund transformation corresponding soliton solutions derived graphically study dark solitons influence profile function nonlinearity coefficient parallel period solitons observed amplitudes dark solitons increase profile function increasing profile function periodic function amplitudes dark soli tons change periodically decrease nonlinearity coefficient leads larger soli tons velocities affect solitons amplitudes elsevier ltd rights reserved
energy efficiency major concern today data centers house large scale distributed processing systems data parallel mapreduce clusters modern power aware systems utilize dynamic voltage frequency scaling mechanism available processors manage energy consumption paper initially characterize energy efficiency mapreduce jobs respect built power governors analysis indicates built power governor provides best energy efficiency job cpu well intensive common cpu frequency across cluster provides best energy efficiency types jobs order identify optimal frequency setting derive energy performance models mapreduce jobs hpc cluster validate models experimentally different platforms demonstrate models used improve energy efficiency machine learning mapreduce applications running yarn platform execution jobs optimal frequencies improves energy efficiency average default governor setting case mixed workloads energy efficiency improves use optimal cpu frequency across cluster
aims population surveys become frequently used method explore stigma help seeking illness beliefs related mental illness methodological quality however differs greatly studies current knowledge seems heavily biased towards high income countries critical appraisal advances shortcomings psychiatric attitude research missing review summarises appraises state art population based attitude research mental health methods systematic review peer reviewed papers reporting representative population studies beliefs attitudes mental disorders published january december results decade covered review considerably papers psychiatric attitude research published whole time period papers originated europe north america australia papers included data low middle income countries vast majority papers used correlational cross sectional analyses used experimental quasi experimental designs data papers obtained face face interviews followed telephone mail online surveys almost half papers case vignettes served stimulus eliciting responses interviewees instruments meeting established psychometric criteria used frequently studied disorder depression paper followed schizophrenia papers reported time trend analyses attitudes beliefs cross cultural comparisons common focus research mental health literacy total papers followed various forms stigma scarcity papers based established theoretical frameworks conclusions current boom attitude research avant garde studies uses profound innovative methodology still blind spots large proportion conventional studies discuss current future methodological challenges psychiatric attitude research needs embrace innovative methodologically sound studies needed provide empirical basis evidence based interventions aimed reducing misconceptions mental disorders improve attitudes towards afflicted
primary ovarian insufficiency poi clinical syndrome defined exhaustion functional potential ovaries prior years consequences poi potentially serious long term fertility reproductive health general health early menopause article provides updated review different etiologic factors pathogenic mechanisms lie behind poi well current novel strategies management challenging disease aimed primary prevention adverse effects estrogen deficiency infertility related early loss ovarian function poi considered multifactorial heterogeneous condition wide spectrum causes cytogenetic autoimmune infectious metabolic iatrogenic causes women affected isolated poi still appear sporadically exact underlying pathology remains unknown early prediction risk poi prevention detrimental consequences poi terms fecundity general health determination characteristics risk assessment poi population may important prediction prevalence poi general population poi widespread consequences general health fertility challenges remain modalities assessment management complex condition review primarily focuses key questions recommendations clinical practice regarding assessment management women diagnosed poi therefore article provides updated review novel findings regarding diagnosis management challenging disease
background hyperactive hypothalamic pituitary adrenal axis hpa axis well known phenomenon bipolar disorder however hypocortisolism also described found associated depression low quality life cardiovascular risk factors patients although pathophysiology related hypocortisolism largely unknown hypocortisolism associated chronic stress exposure inducing initial rise cortisol long term stress may result transition hypocortisolism patients throughout life often exposed chronic stress therefore hypothesized higher age would associated lower hpa axis activity especially among patients without previous mood stabilizing treatment methods cross sectional study consisted bipolar outpatients controls low dose dexamethasone suppression test dst used measure hpa axis activity results patients showed negative association post dst cortisol age nmol per year association gradually increased subgroups naive lithium nmol per year mood stabilizers nmol per year patients exhibiting hypercortisolism characterized younger age female gender whereas patients exhibiting hypocortisolism characterized long disease duration without prophylactic lithium treatment well absence current lithium medication limitations cross sectional study design conclusions negative association hpa axis activity age rendering patients risk developing hypocortisolism association pronounced among patients without previous current lithium prophylaxis
etiology depression fully understood increasing evidence animal models suggests role ventral tegmental area vta pathogenesis paper investigate potential role vta mechanistic target rapamycin torc signaling mediating susceptibility chronic social defeat stress csds well established mouse model depression utilizing genetic viral knockout rictor rapamycin insensitive companion target rapamycin requisite component torc demonstrate decreasing rictor dependent torc signaling catecholaminergic neurons within vta specifically alter susceptibility csds opiate abuse mood disorders often comorbid previous data demonstrate role vta torc mediating opiate reward thus also investigated potential role mediating changes opiate reward following csds catecholaminergic deletion rictor increases water sucrose morphine intake preference two bottle choice assay stress naive mice effects maintained stress vta specific knockout rictor increases water sucrose intake physical csds alter consummatory behavior absence stress findings suggest novel role torc mediating stress induced changes consummatory behaviors may contribute aspects mood disorders elsevier ltd rights reserved
objective depressive comorbidity often associated anorexia nervosa antidepressant medication widely used although rely convincing data scientific literature objectives summarize epidemiological physiological psychopathological literature relation manifestations depression focus clinical trial data assessing use antidepressant medication order clarify strategy use antidepressant adolescence method manual computerised search medline performed relevant published studies assessing association depressive signs major depressive disorder mdd another manual computerised search medline listed clinical trials assessing antidepressant results one hand depressive symptoms common course could different meaning indeed firstly distinguish symptoms inherent mistaken depressive signs instance low self esteem reduced social contacts secondly long term undernourishment held responsible numerous psychological distortions including anxiety depression symptoms insomnia impaired concentration social isolation thirdly natural course also lead depressive moments particular switching purging type recovery mobilizes control narcissistic issues hand mdd also highly prevalent among patients negative prognosis factor thus complex differentiate mdd isolated depressive symptoms could inherent symptomatology raises question role antidepressant medication treatment depression significant benefit antidepressant medication shown clinical trials according international guidelines prescribed second line treatment appropriate refeeding case authentic depressive disorder data appear contradiction frequent use drugs clinical practice discussion nevertheless clinical trials assessing antidepressant treatment suffer methodological weakness concerning size sample choice population evaluation criterion lack proof must raise vigilance concerning antidepressant medication categorically prevent clinician using necessary believe indications prescribing antidepressant patients clinical challenge lies differentiation depressive symptoms transitory likely improve without medication signal presence mdd three criterion could indicative mdd familial history mood disorder major risk factor mdd among relatives chronology appearance disorders mdd pre exists specific symptoms attributed undernourishment reactive depressive signs morning insomnia daily variation depressive symptoms suicidal attempts ideation guilt ideation thus integrating data literature review propose pragmatic therapeutic strategy use antidepressant adolescence lies main categories depressive manifestations therapeutic emergencies obvious severe mdd comorbid immediate antidepressant would required isolated non specific depressive sign medication would relevant supposed improve refeeding psychotherapeutic support intermediary patterns probably frequent situation last case would relevant abstain prescribing medication first line antidepressant medication quickly considered presence one several criterion listed persistence despite refeeding general medical state fragile population patients evaluated standard blood test ecg treatment encephale paris
solar driven photocatalytic hydrogen evolution important bring solar energy fuel energy conversion processes reality however lack highly efficient stable non precious photocatalysts catalysts designed completely expensive noble metals remained elusive hampers large scale industrial application herein first time highly efficient stable noble metal free cds mos nanocomposite designed facile hydrothermal approach assessed photocatalyst water splitting cds mos nanostructures exhibited remarkable photocatalytic hydrogen evolution performance impressive durability excellent hydrogen evolution rate mmolg achieved simulated sunlight irradiation higher values cds mos mmolg cds nanostructures mmolg expensive cds benchmark catalyst mmolg apparent quantum yield reached furthermore obtained hydrogen evolution rate better several noble metal free catalysts reported previously observed high rate hydrogen evolution remarkable stability may result ultrafast separation photogenerated charge carriers transport cds nanorods mos nanosheets thus increases number electrons involved hydrogen production proposed designed strategy believed potentially open door design advanced noble metal free photocatalytic materials efficient solar driven hydrogen production
fall testosterone levels age appears real phenomenon declining testicular function hypothalamic dysregulation appear mechanisms explaining fall testosterone levels age increased prevalence obesity chronic illness ageing men cause large drop testosterone levels independent ageing age related hypogonadism appears different classical causes hypogonadism testosterone levels unequivocally low associated symptoms non specific frail older men low testosterone levels testosterone therapy appears improve qol physical function less frail men however effects testosterone therapy ageing male small inconsistent remains urgent need randomised clinical trials sufficient size duration power determine specific benefits risks testosterone therapy older men
structural deformation caused live loads major concern design multispan suspension bridges deformation characteristics double cable multispan suspension bridges focus paper authors propose simplified mechanical model double cable multispan suspension bridge static analysis analytical formulas calculating maximum deflection girder loaded span deduced basis mechanical model finite element models established verify formulas comparison formulas fem analysis revealed excellent agreement effects major design parameters deformation double cable multispan suspension bridges also studied research shows distribution dead loads top bottom cables little effect deformation sag span ratio main cable imposed significant effect deformation structural deformation decreased decrement top cable sag increment bottom cable sag comparison made double cable multispan suspension bridges traditional multispan suspension bridges regarding deformation results indicated tower stiffness deformation double cable multispan suspension bridge far less traditional multispan suspension bridge
background eurolight project assessed impact headache disorders ten countries using structured questionnaire varying sampling methods lithuania sample selection employed methods line consensus recommendations population based burden headache studies methods survey cross sectional identified residents register service sample inhabitants kaunas city surrounding kaunas region reflecting age range years gender rural urban distributions lithuania medical students called unannounced homes conducted face face interviews employing structured questionnaire results people pre identified sample male female mean age years completed interviews participation proportion gender adjusted year prevalences headache migraine tension type headache tth headache days month probable medication overuse headache pmoh migraine pmoh associated female gender headache types except tth associated significantly diminished quality life migraine caused mean loss paid worktime per affected male per affected female lost per person times due tth much less pmoh headache days month much higher among entire workforce lost productivity migraine estimated tth pmoh headache days month total may translate directly lost gdp alternative calculations based headache yesterday little recall error produced headache corroborating similar losses household work would also drain nation economy findings comparable earlier studies using similar methods russia georgia conclusions multiple burdens headache lithuania indicate substantial ill health unmet need health care heavy burdens individuals matched heavy economic burden particular concern high prevalence headache days month seen also russia georgia health policy lithuania must heed advice effective treatment headache clearly desirable health benefits also expected cost saving
system measuring dielectric propel ties cereal grains mhz coaxial sample holder presented several polar alcohols used calibrate verify permittivity measurements obtained signal flow graph model full two part parameter measurements lowest frequencies mhz phase measurements less accurate lumped parameter model used dielectric loss factor measurements system calibrated measurements air decanol verified measurements octanol hexanol pentanol standard error polar alcohols used verification dielectric constant dielectric loss factor although measurements taken static samples sample holder designed accommodate flowing grain dielectric properties measurements degrees taken four hard red winter wheat cultivars ranging moisture content bulk densities varying data agreed measurements reported literature
building martingale approach global optimization powerful stochastic search scheme global optimum cost functions proposed using change measures states evolve diffusion processes splitting state space along lines bayesian game begin efficacy optimizer contrasted one efficient existing schemes assessed family hard benchmark problems using simulated experimental data potentialities new proposal explored context inverse problem significance photoacoustic imaging wherein superior reconstruction features global search vis vis commonly adopted local quasi local schemes brought relief elsevier ltd rights reserved
objectiveerythropoiesis stimulating agents esas commonly used treat anemia myelofibrosis information predictors response limited methodsresults esa therapy analyzed patients severe anemia inadequate erythropoietin epo levels treatment start resultsaccording revised criteria international working group myelofibrosis treatment research anemia response achieved patients median response duration months multivariate analysis baseline factors associated higher response rate female sex leukocyte count serum ferritin patients features significantly higher response rate remainder respectively patient years follow esa treatment nine patients developed thrombotic complications six arterial three venous accounting events per patient years survival time esa start longer anemia responders non responders conclusionbesides already established predictive value epo levels data help identify patients likely benefit esa treatment
preterm birth exposure childhood sexual abuse csa early physiological psychological adversities linked reduced social functioning across lifespan however joint effects born preterm exposed csa adult social outcomes remains unclear sought determine impact exposure preterm birth csa adult social functioning group extremely low birth weight elbw participants fourth decade life social outcome data prospective longitudinal population based canadian birth cohort initiated years examined age years elbw survivors experienced csa reported poorer relationships partner worse family functioning greater loneliness lower self esteem higher rates avoidant personality problems experienced csa birth weight status also found moderate associations csa self esteem loneliness family functioning adverse effects csa amplified elbw survivors exposure csa appears augment adult social risks associated perinatal adversity individuals born preterm exposed csa appear group particularly high risk adverse social outcomes adulthood
link second hand smoke exposure shse health issues children well established objective study determine short intervention implemented among pediatricians promotes improvement promotion smoking cessation caregivers increase pediatricians awareness smoking cessation trust sct pediatricians clinics randomly assigned control intervention group pediatricians received survey assess baseline knowledge confidence behaviors smoking cessation promotion utilization sct pediatricians intervention group received educational lecture delivered physician two months post intervention pediatricians control intervention group received survey assess changes baseline general pediatricians completed surveys use analysis study intervention group made referrals sct compared controls baseline pediatricians intervention group confident recommending use nrt schedule follow discuss smoking cessation intervention intervention group likely refer caregivers smoking cessation programs discuss child health risk shse recommending use nrt help quit post intervention results study indicate short intervention increase confidence behavior various parameters smoking cessation promotion significantly improve rate pediatricians refer smoking caregivers sct
elucidating complex mechanisms harsh parenting increases risk child psychopathology key targeted prevention requires nuanced methods capture varied perceptions experiences diverse families family socialization interview revised fsi adapted interview developed dodge child development comprehensive semi structured interview characterizing methods parental discipline used young children fsi coding system systematically rates parenting style usual discipline techniques intense physical psychological discipline based rater judgment across two eras birth previous year previous year present current study examined psychometric properties fsi diverse high risk community sample mothers children ages years interrater reliability good excellent codes capturing physically psychologically harsh parenting restrictive punitive parenting styles findings supported fsi convergent incremental validity importantly fsi demonstrated incremental utility explaining unique variance children externalizing internalizing symptoms beyond explained traditional surveys observed parenting fsi appeared particularly promising capturing risk associated young children depressive symptoms generally significantly associated measures harsh parenting overall findings support added value fsi within multi method assessment disciplinary practices across early child development future implications prevention discussed
effectiveness home visiting programs improving children health developmental educational outcomes may depend part quality relationships home visitors parents one aspect working alliance shared bonds goals tasks however little understood modifiable factors associated stronger working alliance purpose study determine home visitors higher levels dispositional mindfulness reported stronger working alliance parents whether association mediated greater psychological well home visitor spring anonymous web based survey administered head start early head start programs pennsylvania responses received home visitors home visitors reported dispositional mindfulness cognitive affective mindfulness scale revised psychological well working alliance parents modified working alliance inventory short form controlling confounders higher mindfulness score among home visitors associated higher score working alliance parents association mediated visitors positive psychological well indirect effect confidence interval among home visitors head start early head start higher levels mindfulness reported stronger working alliance parents interventions promote mindfulness among home visitors may one approach strengthening working alliance parents effectiveness home visiting services
chronic inflammatory diseases cause remains unknown chronic infection however among current hypotheses recent technological advances allowed depth studies gut microflora microbiota contains vast array organisms cultured inflammatory bowel disease associated distinctive changes gut microbiota persist disease flares may play pathogenic role links demonstrated gut microbiota joint inflammation murine models arthritis received little attention human patients recent work nevertheless demonstrated substantial alterations gut microbiota patients rheumatoid arthritis psoriatic arthritis spondyloarthritis differences across diagnoses studies interestingly alterations resemble firmly established inflammatory bowel disease examples include decreased microbial diversity lower frequencies bacterial groups belonging firmicutes phylum known immunoregulatory properties new findings open important new horizons understanding disease developing novel biomarkers treatment strategies societe francaise rhumatologie published elsevier masson sas rights reserved
proliferation application specific accelerators use heterogeneous clusters rapidly increasing consisting processors different architectures heterogeneous cluster aims providing different performance cost tradeoffs different types workloads order achieve peak performance software running heterogeneous cluster needs designed carefully provide enough flexibility explore variety propose design methodology modularize complex software applications data dependencies software application designed way flexibility reconfigured different hardware platforms facilitate resource management features high scalability parallelism using neuromorphic application case study present concept modularization discuss management scheduling communication modules also present experimental results demonstrating improvements effects system scaling throughput
due frequent droughts rapid population growth urban areas adoption practices reduce usage fresh water rise reduction usage fresh water achieved various local water management practices wmp water demand management wdm use alternative water sources greywater recycling rainwater harvesting positive effects wmps widely acknowledged implementation wmps also likely lower wastewater flow increase concentration contaminants sewage turn lead increases sewer problems odour corrosion paper analyses impacts various wmp scenarios wastewater flow contaminant load urban volume quality uvq model used simulate wastewater flow associated wastewater contaminants different wmp scenarios wastewater parameters investigated influence odour corrosion problems sewerage networks due formation hydrogen sulphide parameters chemical oxygen demand cod nitrate sulphate sulphide iron contributed households including biochemical process sewer pipe results help quantify impact wmp scenarios odour corrosion sewerage pipe networks results show implementation combination wdm highly increased concentration selected contaminant triggered formation hydrogen sulphide namely cod sulphate sulphide hand scenario least increase concentration contaminants except iron concentrations increase iron concentrations actually beneficial inhibits formation hydrogen sulphide elsevier ltd rights reserved
one first steps numerous computer vision tasks extraction keypoints images despite large number works proposing image keypoint detectors methodologies able efficiently use visual geometrical information work introduce kvd keypoints visual depth data novel keypoint detector scale invariant combines intensity geometrical data using decision tree present results several experiments showing detector created methodology outperforms state art methods repeatability scores rotations translations scale changes well robustness corrupted visual geometric data additionally far processing time concerned kvd yields best time performance among methods also use depth visual data elsevier rights reserved
dependence tractor wheel torque theoretical tractor motion speed used comparison tractor operation electromechanical transmission installation energy accumulating mechanism without installation case traction asynchronous electric motor operating nominal limit conditions paper also considers dependence diagrams actual input power traction asynchronous electric motor losses due theoretical tractor motion speed tractor wheel torque limited operation traction asynchronous electric motor energy accumulating mechanisms following factors maximum electric motor torque given frequency supply voltage maximum value internal combustion motor output transferred traction asynchronous electric motor grip wheels operation traction asynchronous electric motor energy accumulating mechanisms possibility short power consumption without regard second limitation possible use power internal combustion motor also power stored energy accumulating mechanisms comparison characteristics made tractor operating high gear operating gears two gears operation class tractors analyzed possible cases operation energy accumulating mechanisms without mechanisms operated gears various types work tilling sowing cultivation bulldozing work transport mode case equipment used aggregated class tractor
background growing interest possible applications bright light therapy bet blt might valid alternative add treatment many psychiatric disorders beyond seasonal affective disorder pilot study aims examine whether efficacy bright light therapy blt similar different subtypes mood disorders methods participants newly admitted outpatients major depressive disorder either melancholic features atypical features morning bet administered daily min working days consecutive weeks results participants depressive symptoms improved significantly blt effect seasonality improvement depressive symptoms blt found limitations study small sample size lacked control condition conclusions pilot study provides preliminary evidence blt could promising treatment depression regardless melancholic atypical character depressive symptoms elsevier rights reserved
psychopathy complex developmental personality disorder recent theories linked psychopathy impairment frontostriatal circuitry linking amygdala ventromedial prefrontal cortex vmpfc similar neural regions implicated decision making given importance decision making context personal societal problems together convergence brain regions important decision making psychopathy study decision making psychopathy potential illuminate important cognitive neurobiological bases psychopathy review synthesise past research psychopathy decision making describe three decision making tasks predict would useful understanding cognitive decisional processes psychopathy
seasonal affective disorder sad characterized depression specific seasons generally winter pathophysiological mechanisms underlying sad remain elusive due limited number animal models high availability validity show laboratory cbl mice display photoperiodic changes depression like behavior brain serotonin content cbl mice maintained short day conditions compared long day conditions demonstrated prolonged immobility times forced swimming test lower brain levels serotonin precursor tryptophan furthermore photoperiod altered multiple parameters reflective peripheral metabolism including ratio plasma ltryptophan sum large neutral amino acids compete transport across blood brain barrier responses circulating glucose insulin glucose load sucrose intake restricted feeding condition sensitivity brain serotonergic system peripherally administered glucose data suggest mechanisms underlying sad involve brain peripheral tissue network cbl mice serve powerful tool investigating link seasons mood elsevier ltd rights reserved
today online social networks millions users continue growing reason graphs generated networks usually fit single machine memory time required processing large particular compute centrality measure like betweenness could expensive graphs address challenge paper present parallel distributed algorithm compute betweenness also develop heuristic reduce overall time accomplish speedup best cases
last years several mathematical models coupling differential algebraic equations partial differential equations describing behavior electrical circuits proposed literature investigate properties coupled systems include one dimensional drift diffusion equations describing highly sensitive semi conducting elements circuit extend results coupled systems higher dimensional drift diffusion models allow proper modeling semiconductor devices constituted regions different material properties stability reasons investigate monolithic simulation approach consider two common variants pde discretizations semiconductors system besides finite element method may combined scharfetter gummel approach mixed finite element discretization resulting differential algebraic equations share important properties allow show index always less equal two depends circuit topology information index enables conclude unique solvability associated initial value problems well choose appropriate time stepping methods
leaf growth change along time species spectral characteristics affected researches spectral changing rule tree leaf conditions different time spectral characteristics different tree leaves condition time provide theoretical basis vegetation leaf spectral change rule along time also keys vegetation information accurate identification hyperspectral remote sensing ten kinds common tree species beijing selected leaf spectrum tree species different time observed using spectrometer time observed spectrum dealt first order differential typical bands analysis spectrum difference different tree leaves time contrasted spectrum change laws species different time analyzed effective bands species identification hyperspectral remote sensing condition different time explored results showed leaf spectrum different tree species significant changes along time changing rules different significant differences among different tree species leaves spectrum time proved theoretical basis high precision tree species identification study aims providing basic data theoretical support tree species identification hyperspectral remote sensing building leaf spectrum base database
medical veterinary professional programs demanding may impact student quality life qol aim study compare perceived qol two groups study used questionnaire higher scores mean better perceived qol students internship phase program selected could compare two groups similar way total valid questionnaires gathered apart age body mass index bmi two groups demographically similar scores five domains physical activity limitation due health problems usual role limitation due emotional problems vitality general mental health general health perception also total score statistically higher medical students score one domain social activity limitation due physical emotional problems statistically higher veterinary students bmi physical activity limitation due health problems vitality lost significance binomial logistic regression found general veterinary students lower scores perceived qol social function exception assumed medical students interaction human patients may negative impact score domain even though medical students shown lower perceived qol general population previous studies veterinary students appear slightly lower perceived qol medical students
objectives japanese government launched new occupational health policy called stress check program program mandates workplaces employees conduct stress check program workers least year article gives brief overview critical review program methods reviewed relevant laws guidelines manuals well policy development process policy components program compared using available scientific evidence trends management psychosocial factors work according policies guidelines international bodies european countries results process program policy development based discussion among employer employee representatives occupational health professionals mental health experts scientific evidence shows mandated components program feedback stress survey results physician interview may ineffective however additional components recommended employers stress management skill provision work environment improvement conjunction program may effective improving psychosocial stress work stress check program unique compared global trend psychosocial risk management focuses assessment stress among individual workers conclusion new program may effective improving worker mental health facilitating psychosocial risk management approach japan concerns regarding program include mass leakage collected information possible disadvantages workers labeled high stress
impact conflict parenting outcomes divorce education programs widely explored literature despite prevalence conflict divorce study used outcome data sample participants took online parents forever course participants asked questions positive negative parenting behaviors well levels conflict divorce separation average slight increase conflict post follow simple linear regression analyses indicated change conflict explained significant proportion variance positive parenting scores negative parenting scores results suggest conflict significantly impacts parenting behaviors targeted parents forever course elsevier ltd rights reserved
key element developing high performance smart material electrohydraulic actuators design improved check valves high frequency fluid rectification one method create valves fast frequency response replace single reed valves typically used systems array miniature reed valves robust miniature reed design presented overcome fatigue fabrication limitations observed previous approaches fluid structure interaction individual valve hydraulic fluid modeled using multiphysics software comsol results validated experimental testing array miniature reeds performance array smart material actuator compared larger single reed valve design miniature reed array shown reliably rectify flow high pressure high frequency environment smart material pump
background heroin contaminants may important source allergens young people present case severe endophthalmitis patient also suffered anaphylactoid symptoms hypotension urticaria glottic oedema whenever ingested lemon methods prick tests battery aeroallergens including fruits citrus fruits orange mandarin grapefruit lemon specific ige allergens carried immunodetection performed using patient serum following allergens lemon candida aspergillus penicillium alternaria recombinant alt laboratories diater results skin tests negative candida penicillium aspergillus cladosporium alk spain specific ige antibodies cap thermofisher sweden positive lemon doubtfully candida specific ige tests pollen arthropods fungi dander foods positive lemon serological study fungi ruled fungal infection time immunodetection showed patient serum recognised protein approximately kda lemon peel one approximately kda penicillium perfectly recognised alt conclusions lemon surface contaminated candida fungi heroin addicts positive skin tests lemon possibility serious complications taken account seicap published elsevier espana rights reserved
document beliefs contribution physical activity preschool aged children health held latino mothers farmworker families delineate perceived barriers constraints impose limits preschool aged children physical activity qualitative data obtained semi structured depth interviews mothers preschool aged children living latino farmworker families north carolina mothers universally agree regular vigorous physical activity good preschool aged children health including obesity prevention however excessive physical activity produce illnesses well physical emotional problems limited mothers wanted children engage sedentary forms activity believed would benefit learning physical chemical hazards rural environments distance parks play spaces lack familiarity concerns neighbors constrained children physical activity although physical activity believed beneficial strong cultural beliefs real contextual barriers undermine preschool aged latino farmworker children level physical activity
ionic polymer metal composite ipmc new smart material bends response relatively low applied voltage due special properties low density high toughness large stimulus strain lightness inherent vibration damping ipmc different compared smart materials especially biological applications paper presents accurate dynamic nonlinear black box model predict mechanical displacement features ipmc actuators model includes two main parts adaptive neuro fuzzy inference system anfis nonlinear auto regressive exogenous input narx structure combination universal approximation capability transparency fuzzy inference system training ability neural networks adaptive predictive potential narx structure provide powerful system create accurate transparent identification method estimation prediction interpretation ipmc behaviors model verification ipmc actuator set investigate ipmc displacement features well generate training data validation results proved ability proposed model capture real mechanical displacement features ipmc actuators elsevier rights reserved
correlation blood pressure target organ damage vascular risk long term patient prognosis stronger measurements derived around clock ambulatory monitoring abpm clinic daytime ones numerous studies consistently substantiate asleep mean independent much better predictor cardiovascular disease cvd risk either awake means elevated sleep time sleep time hypertension diagnosed around clock abpm much common suspected patients sleep disorders among others elderly type diabetes chronic kidney disease resistant hypertension hence medical guidelines increasingly recommend abpm make accurate differential diagnosis hypertension versus normotension recognize marked clinical importance adequate management sleep time ingestion time according circadian rhythms hypertension medications six different classes combinations significantly impacts beneficial particularly sleep time control adverse effects mapec monitorizacion ambulatoria para prediccion eventos cardiovasculares ambulatory blood pressure monitoring prediction cardiovascular events study first prospective randomized treatment time investigation designed test worthiness bedtime chronotherapy conventional hypertension medications specifically target attenuation asleep median follow outcomes trial found bedtime chronotherapy strategy advantageous resulting differential reduction total cvd events decrease major cvd events cvd death myocardial infarction ischemic hemorrhagic stroke mapec study plus earlier conducted less refined trials document asleep mean significant prognostic marker cvd morbidity mortality substantiates attenuation asleep mean bedtime hypertension treatment strategy entailing entire daily dose hypertension medications significantly reduces cvd risk general hypertension population vulnerable patients diagnosed chronic kidney disease diabetes resistant hypertension elsevier ltd rights reserved
test campaign launched determine mechanical properties high luminosity large hadron collider lhc nbsn magnet components results used accurately represent mechanical properties finite element models predict stress strain distribution magnets particular attention paid anisotropic mechanical behavior different magnet materials static dynamic test methods applied determining elastic materials behavior highly accurate young moduli obtained nondestructive dynamic methods resonance impulse excitation ambient temperature situ heat cycles
occurrence psychotic autism spectrum disorder asd symptoms represents important clinical challenge consider problem context computational psychiatry approach applied conditions predictive coding symptoms schizophrenia explained terms failure top predictions enhanced weighting bottom prediction errors likewise autism explained terms similar perturbations suggest theoretical overlap may explain overlapping symptomatology experimental evidence highlights meaningful distinctions consistencies disorders hypothesize individuals asd may experience degree delusions without presence additional impairment hallucinations likely indicative distinct process
dynamic nature river channel entrance commonly seasonal dependant evidenced topography river channel entrances east coast borneo influenced north east south west monsoons top surrounding parameters waves tides sedimentatidn well climate change advanced numerical modelling technique frequently used leading approach investigate complicated nature river channel entrance well represent actual conditions designated area paper presented mesoscale numerical modelling method integrating reductionist reduced complexity model approach along local seasonal conditions well represent river channel entrance problem propose management measures model established set numerical equilibrium equations calibrated parameters reflect features regional conditions combination local validated modelling parameters model accurately represented effects monsoons terms hydraulics sediment dynamics petagas river channel entrance verified site data satellite imagery addition accuracy model provides confidence implementation improvement measures river channel entrance improvement scheme includes training channel breakwater improving flushing capacity thus preventing sedimentation upstream flooding allowing proper navigation river conclusion accurate investigational result numerical model successfully demonstrated scientific role solving dynamic river channel entrance serve numerical modelling approach solving similar river channel entrance problems especially east coast borneo predominant inter annual seasonal variations elsevier ltd rights reserved
purpose cilostazol pletal phosphodiesterase inhibitor approved united states reduce symptoms intermittent claudication cyclic adenosine monophosphate levels increase inhibition phosphodiesterase resulting anti platelet anti inflammatory vasodilatory effects diabetes mellitus chronic disease causes endothelial platelet dysfunction leading microvascular macrovascular complications mini review highlights emerging evidence suggesting benefits using cilostazol treating microvascular complications associated diabetes mellitus methods review literature conducted using pubmed embase databases focusing cilostazol use diabetes mellitus results cilostazol demonstrated renoprotective effects patients diabetic nephropathy reducing serum soluble adhesion molecule monocyte chemoattractant protein cilostazol anti inflammatory actions predictably attenuate glomerular damage increased leukocyte adherence additionally cilostazol delayed renal dysfunction secondary type diabetes mellitus albuminuria reduced likely resulting inhibition nuclear factor kappa induced inflammatory endothelial markers cilostazol anti inflammatory actions addition vasodilatory actions relieved retinal hypoxia decreased excessive production retinal blood vessels suggesting benefit diabetic retinopathy cilostazol improve neuropathy symptom scores signifying may beneficial patients diabetic peripheral neuropathy without diabetic nephropathy diabetic retinopathy conclusions cilostazol pleiotropic effects may beneficial patients type diabetes mellitus diabetic nephropathy additional larger studies need conducted assess benefits risks using cilostazol alternative agent treating patients diabetic microvascular complications
urgent problems power industry century require creation smart energy systems providing high efficiency generation transportation consumption electricity well increased requirements manageability energy systems environmental resource saving characteristics one solutions many problems power industry creation new high efficiency electrical equipment intelligent power systems based superconducting technologies ensure qualitatively new level functioning electric power industry industrialized countries superconducting power cables one advanced developments superconducting devices taking account obvious advantages superconducting cable lines transmission large power flow electric network compared conventional cables federal grid company unified energy system pjsc fgc ues initiated program includes creation high temperature superconducting cable lines two cable lines accessories transmitted power made tests types cables conducted center fgc ues jsc moscow test results presented report
paper draws upon controversy use indigenous related sports emblems recently sparked series protests across united states washington redsk name imagery focuses visual aspect debate tracing white supremacist foundations washington team insignia institutional construction native identity popular indian head pennies gold coins buffalo nickels period pointing seemingly paradoxical discrepancy minted messages systematic political legal military invasion american indian sovereignty period proceeds deconstruct paradox exposing numismatic pictorial language manifestation ideological project configurations power remained unchanged day continued circulation indigenous based iconography contemporary american context shows cultural imagination continues serve powerful rationale european america historical national political narrative also form anti conquest obscures enacts established formulas colonial domination control observing alterations washington redsk logo design across key socio historical moments second half twentieth beginning twenty first century analysis explores various forms national anxiety transcend identity politics representation light regards recent activism mass mediated symbolization indigenous identity important arena centuries old hegemonic discourses contested new venues self determination internal decolonization
purpose demonstrate role diffusion tensor imaging kidney diabetic patients correlate renal fractional anisotropy apparent diffusion coefficient adc renal cortex urinary serum biomarkers diabetes material methods prospective study conducted upon diabetic patients males females mean age years age sex matched volunteers diabetic patients micro normoalbuminuric macroalbuminuric patients volunteers underwent diffusion tensor imaging kidney adc renal cortex calculated regions interests kidneys results mean adc renal cortex diabetic patients significantly different volunteers cut renal adc used differentiate diabetic patients volunteers auc accuracy adc calculated renal cortex patients macroalbuminuria significantly different patientswithmicro normoalbuminuria adc renal cortex diabetic patients correlated urinary albumin urinarynag urinary tgf beta serum creatinine conclusion adc renal cortex may help differentiation diabetic kidney volunteers prediction presence macroalbuminuria diabetic patients correlated urinary serum biomarkers diabetes
dielectric barrier discharge atmospheric cold plasma dacp treatment evaluated inactivation escherichia coil surface morphology color carbon dioxide generation weight loss bulk romaine lettuce commercial plastic clamshell container lettuce samples packed model bulk packaging configuration three rows either layers container treated dacp min dacp treatment reduced number coil leaf samples layer configurations log cfu lettuce significant correlation sample location largest bulk stacking layers greater degree reduction log cfu lettuce observed top layer shaking container increased uniformity inhibition dacp significantly change surface morphology color respiration rate weight loss samples properties differ significantly according location bulk stack dacp treatment inhibited coli bulk lettuce clamshell containers uniform manner without affecting physical biological properties thus holds promise post packaging process fresh fresh cut fruits vegetables published elsevier ltd
objectives aimed evaluate safety total body irradiation bone marrow transplant materials methods analyzed patients male female underwent total body irradiation hematopoietic stem cell transplant may march median age total body irradiation years range median observation time days range initial diagnoses acute lymphoblastic leukemia patients acute myeloid leukemia patients chronic myeloid leukemia patients myelodysplastic syndrome patients malignant lymphoma patients mucopolysaccharidosis patients neuroblastoma patients diseases patients total fractionated dose used total body irradiation patients patients single dose total body irradiation administered patients patients received chemotherapy consisting cyclo phosphamide alone results ocular complications observed patients hypothyroidism interstitial pneumonia obliterative bronchiolitis veno occlusive disease developed patients growth abnormality observed pediatric patients use lower dose fractionated total body irradiation decrease incidence adverse events however nonmyeloablative conditioning low dose single fraction total body irradiation reduced incidence adverse events three patients underwent total body irradiation reirradiation therapy achieved long term survival without adverse events conclusions fractionated total body irradiation given lower dose decrease incidence adverse events
random numbers highly used applications like computer simulation gambling statistical sampling cryptography high entropy random source produce better quality random data paper work generation high quality random numbers based cellular automata propose three dimensional generate random sequence also propose various enhancements based pseudorandom number generator prng discuss five variants using two dimensional analyze switching sequence achieve high quality randomness provide architectures rules algorithms proposed variants respect cell structures done software implementation proposed variants tested produced sequences using internationally accepted standard random numbers known diehard analysis results made per recommendations ansi standards similar criteria applied compare methods based results able find best prng producing high quality random sequence
paper presents methodology based decision support system dss employs remote sensing field survey data geographic information system gis identify potential rainwater harvesting areas rwh dss implemented obtain suitability maps evaluate existing rwh structures study area dss inputs comprised maps rainfall surplus slope potential runoff coefficient land cover use soil texture basis analytical hierarchy process analysis taking account five layers spatial extents rwh suitability areas identified multi factor evaluation spatial distribution classes suitability map showed excellent good areas mainly located southern western parts study area average study area classified excellent good rwh respectively area classified moderately suitable poorly suited unsuitable respectively existing rwh structures categorized successful within good structures areas followed moderately suitable structures excellent areas structures
purpose glycosaminoglycan gag chemical exchange saturation transfer cest imaging method gagcest makes possible assess quantify gag concentration human cartilage biochemical imaging technique facilitates detection loss gag course osteoarthritis gagcest technique used analyse perilesional zone plz adjacent repair tissue cartilage repair surgery determine whether biochemical changes present sense degeneration method asymmetries plz cartilage defects patients treated microfracturing matrix associated autologous chondrocyte transplantation mact measured gagcest whole body system results correlated gagcest asymmetries healthy reference cartilage measured anterior posterior plz repair tissue results mean gagcest asymmetry anterior plz posterior plz anterior posterior difference anterior plz anterior posterior plz posterior mean statistically significant measurements mean plz reveal significant results conclusions gagcest method provides potentially useful biomarker loss gags indicating cartilage degeneration plz pre operative post operative monitoring biomechanical state cartilage might influence intra operative decision making concerning extent cartilage resection might give information success treatment post operatively
eating disorders pose risks health wellbeing young adolescents prospective studies risk factors scarce impeded prevention efforts longitudinal study aimed examine risk factors eating disorder symptoms population based birth cohort young adolescents years participants gateshead millennium study birth cohort girls boys completed self report questionnaire measures eating disorder symptoms putative risk factors age years years years including dietary restraint depressive symptoms body dissatisfaction body mass index bmi also measured age within time correlates eating disorder symptoms years age greater body dissatisfaction sexes girls higher depressive symptoms sexes higher eating disorder symptoms years old significantly predicted higher eating disorder symptoms years old dietary restraint years old predicted boys eating disorder symptoms age girls factors predict eating disorder symptoms years age bmi age girls dietary restraint years body dissatisfaction years age sexes population based study different patterns predictors correlates eating disorder symptoms found girls boys body dissatisfaction purported risk factor eating disorder symptoms young adolescents developed concurrently eating disorder symptoms rather preceding however restraint age eating disorder symptoms age years predict year eating disorder symptoms overall findings suggest efforts prevent disordered eating might beneficially focus preadolescent populations authors published elsevier ltd
aim study assess inter rater variability visual interpretation pib pet images regarding positivity negativity amyloid deposition obtained multicenter clinical research project japanese alzheimer disease neuroimaging initiative adni results visual interpretation also compared semi automatic quantitative analysis using mean cortical standardized uptake value ratio cerebellar cortex mcsuvr total pib pet scans including mild alzheimer disease mild cognitive impairment normal cognitive control cases acquired adni baseline scans analyzed based visual interpretation three independent raters followed consensus read case classified positive equivocal negative deposition ternary criteria dichotomized merging former two binary criteria complete agreement visual interpretation three raters observed cases cohen kappa average ternary criteria kappa binary criteria cases interpreted visually positive consensus read showed significantly higher mcsuvr visually negative positive negative decision visual interpretation dichotomized cut value mcsuvr significant positive negative associations observed mcsuvr number raters evaluated positive rho negative rho interpretation cases disagreement among raters showed generally low mcsuvr inter rater agreement almost perfect pib pet scans positive negative decision visual interpretation dichotomized cut value mcsuvr cases disagreement among raters tended show low mcsuvr referring quantitative method may facilitate correct diagnosis evaluating images low amyloid deposition
year old girl presented back leg pain left arm leg paresis lumbar puncture suggestive lymphocytic meningitis without identified organism second lumbar puncture demonstrated large number lymphoid cells positive immunohistochemical staining proving diagnosis neurolymphomatosis brain spine mri demonstrated involvement cervical lumbosacral nerve roots fdg pet showed multiple bone metastases addition nerve involvement postchemotherapy fdg pet demonstrated complete metabolic response
united nations launched global strategy women children health accelerate progress maternal child health commission information accountability established ensure oversight accountability women children health outlined framework three processes monitor review act paper assesses progress processes effective monitoring depends functional civil registration vital statistics system review requires counting deaths identifying contributing factors final critical step action prevent similar deaths maternal death surveillance response includes steps strengthens accountability strategies underway improve accountability severe maternal morbidity perinatal mortality post agenda adds greater focus reducing inequalities increasing availability quality disaggregated data accountability human rights agenda requires engagement communities health providers foundation accountability women children health published elsevier ltd
nonlinear stability study neutron coupled thermal hydraulics instability carried several researchers boiling water reactors bwrs focus studies identify sub critical supercritical hopf bifurcations supercritical hopf bifurcation soft safe due fact stable limit cycles arise linearly unstable region linear global stability boundaries bifurcation well known subcritical bifurcations considered hard dangerous due fact unstable limit cycles nonlinear phenomena exist linearly stable region linear stability leads stable equilibrium regions infinitesimally small perturbations however finite perturbations lead instability due presence unstable limit cycles therefore evident linear stability analysis sufficient understand exact stability characteristics bwrs however effect bifurcations stability boundaries rarely discussed present work identification global stability boundary demonstrated using simplified models five different models different thermal hydraulics feedback investigated comparison earlier works current models also include impact adding rate change temperature void reactivity well effect void reactivity rate change temperature using bifurcation analysis models globally stable region parameter space identified globally stable region stable solutions even unstable limit cycles hence system stable irrespective size perturbation regions elsevier rights reserved
purpose iam study investigate effect healthcare associated infections hais broad spectrum antibiotic use newborn period asthma allergic rhinitis atopic dermatitis material methods seventy three children treated hais newborn period neonatal intesive care unitin years period siblings healthy newborn period included study parents answered detailed questionnaire children examined complete blood count serum total specific levels studied results ventilator associated pneumonia observed blood stream infection clinic sepsis children hais asthma significantly higher hais group compared sibling group whereas significant difference allergic rhinitis atopic dermatitis among groups nonallergic subjects allergic children compared children hospitalised treated broad spectrum antibiotics newborn period almost times likely allergic disease conclusion asthma significantly higher hai group allergic disease risk seems increase children treated broad spectrum antibiotics hais newborn period
range risk factors lead opioid use substance related problems srp including childhood maltreatment elevated impulsivity psychopathology constructs highly interrelated childhood maltreatment associated elevated impulsivity trauma related psychopathology posttraumatic stress disorder ptsd impulsivity particularly urgency ptsd related prior work examined association constructs substance related problems independently unclear multi faceted constructs maltreatment types positive negative urgency associated one another srp current study used structural equation modeling sem examine relations among childhood maltreatment trait urgency ptsd symptoms srp sample individuals history opioid use initial model included paths type childhood maltreatment positive negative urgency ptsd srp fit data well pruned model excellent fit identified suggested emotional abuse positive urgency negative urgency directly related ptsd symptoms ptsd symptoms directly related srp furthermore significant indirect effects suggested emotional abuse negative urgency related srp via ptsd symptom severity results suggest ptsd plays important role severity srp elsevier ltd rights reserved
multi mode mobile equipment requires efficient radio frequency filtering solutions solve interference problems umts system integrated mobile television function filtering solution comprising band pass filter band stop filter based temperature stable bulk acoustic wave resonator baw technology proposed letter filters measurably demonstrate low insertion loss similar high rejections fast roll similar mhz pass band stop band temperature coefficient frequency tcf low ppm degrees filters achieved five times lower conventional baw filter low tcf critical importance particularly sharp skirts trivial frequency changes associated temperature variation could lead failure filter specifications skirt corners proposed filtering solution applied minimize interference present similar systems mobile phones integrated satellite radio gps navigation
introduction connective tissue growth factor ctgf mediates hypertrophy proliferation extracellular matrix synthesis matrix metalloproteinase mmp plays role airway extracellular matrix remodeling correlation ctgf mmp airway remodeling asthma unknown study investigated lung ctgf expression correlation mmp airway structural changes murine model asthma material methods female balb mice sensitized challenged intraperitoneal injections intranasal phosphate buffered saline pbs ovalbumin ova airway responsiveness serum ova specific ige measured airway structural changes quantified morphometric analysis differential cell counts mmp mmp tissue inhibitor metalloproteinase timp evaluated bronchoalveolar lavage fluid balf lung ctgf determined western blot results serum ova specific ige level airway responsiveness enhanced pause penh significantly higher sensitized mice challenged ova compared pbs challenged mice mmp mmp timp balf significantly higher ova mice airway structural changes animals lungs ova challenge showed increased thickness smooth muscle layer numbers goblet cells inflammatory cells eosinophils near airways perivascular areas lung ctgf expression significantly increased ova challenged mice ctgf expressions positively correlated mmp timp thickness smooth muscle layer conclusions study indicates ctgf upregulation correlates mmp probably involved pathogenesis airway remodeling asthma
paper application machine learning techniques development constitutive material models investigated flow stress model strain rates ranging quasi static highly dynamic temperatures ranging room temperature obtained beginning directly experimental stress strain data copper incrementally objective fully implicit time integration scheme employed integrate hypo elastic constitutive model implemented finite element code evaluation accuracy performance flow stress models derived symbolic regression assessed comparison taylor anvil impact data results obtained free form constitutive material model compared well established strength models preston tonks wallace ptw model mechanical threshold stress mts model preliminary results show candidate free form models comparing well data regions stress strain space sufficient experimental data pointing potential means rapid prototyping future model development well use machine learning capturing data guide advanced model development elsevier rights reserved
study evaluated whether common self report measures television game violence exposure represent reliable valid measurement tools three self report measuresdirect estimates user rated favorites agency rated favoriteswere assessed terms test retest reliability criterion validity relationship coded media diaries construct validity relationship aggression gender total adolescents participated two wave survey completed two media diaries game violence three self report measures reliable valid television violence direct estimates achieved test retest reliability construct validity criterion validity could established television violence measures media diary valid criterion television violence findings indicate direct estimates favorites valid measures game violence whereas television violence direct estimates valid conclude discussion ways improve upon reconceptualize media violence exposure measurement
termination millennium development goals gave birth sustainable development goals sdgs target provide unhindered access safe economical drinking water sanitation survey research adopted stratified sampling technique captured households well structured questionnaire consisting open closed ended questions distributed questions line water sanitation hygiene wash recommendations drinking water sanitation household surveys examined access safe water regarding accessibility availability affordability acceptability ado odo ota ogun state nigeria personal interviews conducted capture emotional discretion respondents towards subject matter cross tabulation multinomial logit model used analyze relationship variables water access results obtained showed water access within study area mostly limited private sources level quality accessibility study reveals fate placed government water facilities dwindled drastically furthermore study highlighted need revisit government policies inclusion subsidy cost recovery rainwater harvesting effective tools improving encouraging equity water access elsevier ltd rights reserved
background methodshealth systems complex constantly adapt changing demands complex adaptive characteristics rarely considered current bureaucratic top approaches health system reforms aimed constrain demand expenditure growth economic focus fails address needs patients providers communities ultimately results declining effectiveness efficiency health care system well health wider community needs focused complex adaptive health system represented healthcare vortex model build needs focused complex adaptive health system illustrated eastern deanery aids relief program approaches poor neighbourhoods nairobi kenya findings conclusionsa small group nurses community health workers focused care terminally ill hiv aids patients work identified additional problems tuberculosis underdiagnosed undertreated local technician trained run local lab courier services helped reach need collaboration ministry health established local hiv treatment programmes philanthropists helped supplement treatment nutrition support maternal child hiv prevention adolescent counselling services addressed additional needs theory healthcare vortex indeed matches empery real world experiences locally developed delivered adaptive people centred health systems bottom community provider initiated approach deliver highly effective sustainable health care despite significant resource constraints
osteoarthritis low grade systemic inflammatory disease many inflammatory mediators known elevated peripheric blood blood platelet lymphocyte ratio plr mean platelet volume mpv accepted novel markers many systemic inflammatory disorders investigated synovitis free radiographic yet aim study evaluate levels blood plr mpv radiographic hip total patients evaluated retrospectively certain exclusion criteria primary hip included age sex height weight body mass index neutrophil lymphocyte platelet counts erythrocyte sedimentation rate esr plr mpv levels recorded kellgren lawrence grading hip joints performed patients divided groups grades mild moderate grades severe hip mean age mean neutrophil lymphocyte platelet counts mean mpv mean plr mean esr statistically significantly different mild moderate hip group severe hip group univariate analysis older age higher mpv plr esr severely associated severe hip multiple logistic regression analysis mpv plr esr emerged independent predictors severe hip results present study first time literature suggest blood plr mpv novel inflammatory markers predicting radiographic severity hip daily practice
pre operative psychological assessment recommended international guidelines bariatric surgery candidates thereby service teams caring bariatric patients include least one mental health provider psychologist psychiatrist objective study evaluate psychology psychiatry resources practices specialized obesity centers csos created french ministry health cso coordinators contacted mail collect general information centers number bariatric operations secondly psychologists psychiatrists center completed anonymous questionnaire assessing professional practices organization care pathways vast majority cso coordinators answered survey results show significant differences shortages terms psychology psychiatry resources available psychologists psychiatrists stated systematically meet new patients surgery operation however psychologists psychiatrists systematically meet patients surgery nevertheless professionals provide psychology assessments offer psychological follow indicating similarity regarding practices psychologists psychiatrists results highlight place psychological psychiatric evaluations french csos emphasize absence mental health providers several services post operative psychological follow usually provided would appropriate create clear recommendations post operative psychological psychiatric long term follow
since singapore set implementing mitigation energy efficiency measures key sectors achieve unilaterally pledged reductions greenhouse gas ghg emissions business usual bau levels carbon dioxide emissions fossil fuel fired power plants major focus emissions abatement expected reduction electricity generation sector paper explore singapore various strategies electricity generation sector fulfil target use energyplan optimization model assess impact strategies emissions singapore electricity generation sector comparison bau scenario bau target emissions reduction trajectory three emissions reduction alternative policy scenarios denoted aps aps aps iii carried energyplan simulation results indicate three aps scenarios achieve carbon emissions reduction target singapore electricity generation sector results furthermore suggest electricity generation associated emissions reduction target met measures already available vulnerabilities identified singapore electricity generation fuel mix emission reduction strategies beyond outlined elsevier ltd rights reserved
total knee arthroplasty tka total hip arthroplasty tha common successful surgical interventions relieve osteoarthritis pain control postoperative pain critical patients fully participate required physical therapy influential factor effective postoperative knee rehabilitation currently opiates mainstay managing postoperative orthopedic surgery pain including tka tha pain recently issues including efficacy dependence overdose death opiates made clinicians researchers critical use opioids treating nonmalignant skeletal pain present report nonopiate therapy using monoclonal antibody raised nerve growth factor anti ngf assessed ability increase spontaneous activity operated knee joint mouse model orthopedic surgery pain induced drilling coring trochlear groove mouse femur horizontal activity velocity vertical rearing continually assessed hours day night period using automated activity boxes effort reduce observer bias capture night activity mice active days orthopedic surgery marked reduction spontaneous activity vertical rearing anti ngf significantly attenuated decline present data suggest anti ngf improves limb use rodent model joint orthopedic surgery anti ngf may useful controlling pain orthopedic surgeries tka tha
deficits response inhibition heightened impulsivity linked psychiatric disorders aggression investigated clinical groups well individuals trait characteristics yielding insights underlying neural behavioral mechanisms response inhibition impulsivity motor inhibition tasks employed studies however lacked emotional component crucial given response inhibition impulsivity attain salience within socio emotional context fmri study selected group high trait aggression one low trait aggression males completed aggression questionnaire neural activation compared emotional version including angry neutral faces stop signal task behavioral results revealed impaired response inhibition associated higher motor impulsivity accompanied attenuated activation brain regions involved response inhibition including pre supplementary motor area sma motor cortex together findings offer evidence reduced inhibition capacity present notably response inhibition improved anger trials groups suggesting facilitation effect heightened activation related brain regions groups inclusion anger stimuli enhanced activation motor somatosensory areas modulate executive control limbic regions including amygdala summary investigation response inhibition individuals high low trait characteristics affords useful insights underlying distinct processing mechanisms contribute investigation trait markers clinical context without deal complex mechanisms clinical disorder contrast mechanisms emotional response inhibition differ groups hence specific emotional influence interacting trait aggression elsevier inc rights reserved
swarm cognitive behavior bees readily translates swarm intelligence social cognition thus giving rise rapid promotion survival skills resource allocation paper presents novel cognitively inspired artificial bee colony clustering abcc algorithm clustering evaluation model manage energy consumption cognitive wireless sensor networks cwsns abcc algorithm optimally align dynamics sensor nodes cluster heads cwsns sensor nodes cluster heads adapt topological changes network graph time one major challenges employing cwsns maximize lifetime networks abcc algorithm able reduce balance energy consumption nodes across networks artificial bee colony abc optimization attractive application cognitive behaviors artificial bees match perfectly intrinsic dynamics cognitive wireless sensor networks additionally employs fewer control parameters compared heuristic algorithms making identification optimal parameter settings easier simulation results illustrate abcc algorithm outperforms particle swarm optimisation pso group search optimization gso low energy adaptive clustering hierarchy leach leach centralized leach hybrid energy efficient distributed clustering heed energy management cwsns proposed algorithm increasingly superior approaches number nodes network grows
schedules major concerns construction planning management mutual interferences among construction activities long distance diversion tunnels lddts complicated crisscrossing intensive layout affect scheduling degree especially lithology conclusive influence underground construction lithology determination methods current construction simulation trend extrapolation observations fully consider lithology inherent characteristics transition probability different lithological classifications present study authors propose hierarchical simulation model coupling critical path method cpm cycle operation network cyclone arrange intricate construction sequence lddts additionally markov prediction model embedded cyclone model specific component consider lithological uncertainty estimate construction parameters cycle automatically based proposed simulation model real time construction schedule analysis system built case study project analyzed demonstrate feasibility methodology highlight capabilities project reasonable planned schedule proposed optimal equipment selection determined excavation intensity balanced verified simulation model considering lithological uncertainty using markov process provides higher level accuracy prediction traditional simulations finally regulatory measures presented site management based simulation results deviations actual planned schedules american society civil engineers
bone loss central feature rheumatoid arthritis considered represent sign irreversible structural damage triggered chronic inflammation recent evidence however suggests autoantibodies important earlier driver bone damage article summarizes current evidence role related autoantibodies mediating bone loss rheumatoid factor antibodies recognizing modified citrullinated proteins central features autoimmunity patients despite used diagnostic markers many years ascertaining differentiation forms inflammatory arthritides role antibodies pathogenic players long unrecognized recently several pieces evidence suggested bone resorbing osteoclasts highly responsive related autoantibodies providing novel link autoimmunity bone developments allowed unraveling underlying mechanisms responsible well known clinical observation related autoantibodies associated severe disease course present rheumatoid factor antibodies recognizing citrullinated proteins considered potent osteoclast inducers triggers bone loss arthritis
effort screen alginolytic cellulolytic bacteria putrefying invasive seaweed sargassum species accumulated barbados coast potent bacterial strain isolated bacterium simultaneously produced alginate lyase cellulase identified exiguobacterium alg via phylogenetic approach targeting rrna gene produced alginate lyase cellulase exhibited maximal enzymatic activity degrees degrees respectively max values recorded protein respectively alginate lyase protein respectively cellulase first order kinetic analysis thermal denaturation produced alginate lyase cellulase temperature range degrees degrees revealed enzymes thermodynamically efficient displaying higher activation energy enthalpy denaturation enzymatic properties indicate potential industrial importance bacterium algal biomass conversion appears first report assessing efficacy bacterium production alginate lyase cellulase elsevier rights reserved
ensuring safety efficiency crane operation challenging due complexity lifting operation real time lifting path planning system developed paper aims provide optimized collision free lifting path mobile crane operators first contribution developed system take advantage crane mounted sensors components hardware collect object information additional device needs purchased secondly data storage path planning optimizing visualizing functions designed minimize required computer memory system installed applied crane mounted controller real time operation additional calculation capacity required system tested real construction sites demonstrated ability generate lifting paths satisfying operators expectation system independent software package installed mobile cranes mounted necessary hardware
geosynthetics including geogrids geotextiles extensively used stabilisation soil reinforcement several geotechnical structures foundations abutments walls slopes applications soil geosynthetic interaction plays determinant role paper describes experimental study carried using large scale pullout test apparatus aiming investigate pullout behaviour different geosynthetics embedded granite residual soil study involved two geogrids one biaxial uniaxial one geocomposite reinforcement high strength geotextile one geotextile soil compacted different relative densities test results revealed soil geosynthetic interaction pullout loading conditions highly influenced geosynthetic properties soil density regardless soil density biaxial geogrid exhibited higher pullout resistance geosynthetics maximum pullout force deformation along length geotextiles considerably pronounced along geogrids conditions adopted study soil geosynthetic pullout interaction coefficients ranged general values scale effect correction factor obtained geotextiles slightly lower value recommended federal highway administration absence test data
purpose study verified smoothness reaching movements able quantitatively evaluate effects two three dimensional images movement healthy people addition clinical data cerebrovascular accident patients also analyzed method subjects ten healthy adult volunteers two male patients previous cerebrovascular accidents participated methods subjects tasked reaching objects shown display target virtual limb rendered computer graphics shown display movements virtual limb synchronized subject healthy subjects reached targets dominant arm cerebrovascular accident patients used paretic arm polarized display polarized glasses used subjects shown three dimensional images present study jerk cost used quantify smoothness movement results six healthy subjects significantly smoother reaching movements viewing three dimensional images two cerebrovascular accident patients tended smoother movements response three dimensional images conclusion analysis smoothness movement able detect influence depth cue vision movement quantitatively healthy subjects cerebrovascular accident patients
sexual reproductive health recognised essential component good health personal development however number studies suggest persons disabilities pwd often marginalised sexual reproductive health programmes study depth interviews conducted sexually active women men reproductive ages different types disabilities order examine access sexual reproductive health services durban south africa majority respondents revealed sexual reproductive health services big part lives however seemed huge gap need services rights access services gender compounded negative experiences women disabilities women mentioned health providers appear surprised need family planning services given choices suitable birth control methods findings reveal need address access sexual reproductive health services pwd
salmonella major cause foodborne illness worldwide allowed present food countries purpose study develop simple alternative method detection salmonella based functionalized polyethylene surfaces salmonella typhimurium used model bacterium film treated using dielectric plasma order alter wettability surface consequently introduce functionality surface film characterized atr ftir spectroscopy revealed presence stretching ketones aldehydes carboxylic acids antibodies antigens salmonella typhimurium respectively immobilized surface activation carboxylic group using nhs edc followed protein evidences atr ftir scanning electron microscopy optical microscopy showed presence typhimurium attached plasma treated surfaces via two types anti salmonella antibody plasma treated film developed simple allows efficient association bacterial cells treated surfaces without necessity time consuming centrifugation washing steps isolation cells material considered smart material applicable typhimurium detection elsevier rights reserved
role emotion regulation subclinical symptoms mental disorders adolescence yet well understood meta analytic review examines relationship habitual use prominent adaptive emotion regulation strategies cognitive reappraisal problem solving acceptance maladaptive emotion regulation strategies avoidance suppression rumination depressive anxiety symptoms adolescence analyzing effect sizes studies calculated overall outcomes across depressive anxiety symptoms well psychopathology specific outcomes age examined continuous moderator via meta regression models results random effects analyses revealed habitual use emotion regulation strategies significantly related depressive anxiety symptoms overall adaptive emotion regulation strategies showing negative associations less symptoms depressive anxiety symptoms whereas maladaptive emotion regulation strategies showed positive associations symptoms less frequent use adaptive frequent use maladaptive emotion regulation strategies associated depressive anxiety symptoms comparably respective directions regarding psychopathology specific outcomes depressive anxiety symptoms displayed similar patterns across emotion regulation strategies showing strongest negative associations acceptance strongest positive associations avoidance rumination findings underscore relevance adaptive also maladaptive emotion regulation strategies depressive anxiety symptoms youth highlight need investigate patterns emotion regulation potential transdiagnostic factor
chronic use selective serotonin reuptake inhibitors ssris treatment depression linked osteoporosis study investigated effect chronic ssri use fracture healing two murine models bone regeneration first performed comprehensive analysis endochondral bone healing femur fracture model mice treated fluoxetine commonly prescribed ssri developed normal cartilaginous soft callus days fracture demonstrated significantly smaller biomechanically weaker bony hard callus days order dissect mechanism resulted smaller bony regenerate used intramembranous model bone healing revealed fluoxetine treatment resulted significantly smaller bony callus days postinjury order test whether smaller bony regenerate following fluoxetine treatment caused inhibition osteogenic differentiation mineralization employed vitro experiments established fluoxetine treatment decreases osteogenic differentiation mineralization effect serotonin independent finally translational approach tested whether cessation medication would result restoration regenerative potential however histologic analysis revealed non union formation animals fibrous tissue interposition within callus conclusion fluoxetine exerts direct inhibitory effect osteoblast differentiation mineralization shown two disparate murine models bone repair discontinuation drug result restoration healing potential rather led complete arrest repair process besides well established effect ssris bone homeostasis study provides strong evidence fluoxetine use negatively impacts fracture healing american society bone mineral research
natural disasters projected increase many regions world due growing exposure human activities combined increased vulnerability projected increase frequency intensity effects climate change global warming combat disasters university network gaining importance plays proactive role disaster risk reduction university capacity educate research bring stakeholders together share experiences increase knowledge base facilitate improved decision making policy practice since university center excellence regard research disseminating research outputs end users desktop research identifies role networking various risk reduction approaches carried university stakeholders illustrates example disaster resilient habitat rainwater harvesting university provided key interventions reduce disaster impacts conclusion paper formulates provides model strengthening networking universities build disaster resilient coastal communities elsevier ltd rights reserved
previous studies suggest pregnant women children particularly vulnerable adverse effects air pollution prospective cohort study pregnant women children enables identification specific effects critical periods paper describes design air pollution exposure assessment participants generation study population based prospective cohort study early pregnancy onwards women netherlands individual exposures levels home address estimated mothers children using combination advanced dispersion modelling continuous monitoring data taking account spatial temporal variation air pollution concentrations full residential history considered observed substantial spatial temporal variation air pollution exposure levels generation study provides unique possibilities examine effects short long term air pollution exposure various maternal childhood outcomes identify potential critical windows exposure
rheumatoid arthritis chronic autoimmune disease characterized joint destruction caused infiltrating leukocytes including cells important role cell stimulation played stimulatory signal transducer inhibitory ctla ccl produced circulating cells plays active role chemotactic activity cells aim study examine associations polymorphisms within ctla ccl genes examined patients female male mean age years rheumatoid arthritis healthy subjects female male disease activity determined basis das score patients das classified subjects active form statistically significant differences distribution studied genotypes alleles patients control group statistically significant difference observed distribution ctla exon genotypes patients das increased frequency genotype among patients das revealed results study suggest significant association ccl ctla exon gene polymorphisms polish population results indicate possible association ctla exon gene polymorphism activity
software models defined code abstractions iteratively refined restructured evolved due many reasons reflecting changes requirements modifying design enhance existing features understanding evolution model posteriori change detection approaches proposed models majority existing approaches successful detect atomic changes however composite changes refactorings difficult detect due several possible combinations atomic changes eventually hidden changes intermediate model versions may longer available moreover multitude refactoring sequences may used describe model evolution paper propose multi objective approach detect model changes sequence refactorings approach takes input exhaustive list possible types model refactoring operations initial model revised model generates output list refactoring applications representing good compromise following two objectives maximize similarity expected revised model generated model applying refactoring sequence initial model minimize number atomic changes used describe evolution fact minimizing number atomic changes important since maybe easier designer understand analyze sequence refactorings composite model changes rather equivalent large list atomic changes weissgerber diehl due huge number possible refactoring sequences metaheuristic search method used explore space possible solutions end use non dominated sorting genetic algorithm nsga find best trade two objectives paper reports results empirical study multi objective model changes detection technique applied various versions real world models taken open source projects one industrial project compared approach simple deterministic greedy algorithm multi objective particle swarm optimization mopso existing mono objective changes detection approach two model changes detection tools based computational search statistical test results provide evidence support claim proposal enables generation changes detection solutions correctness higher average using variety real world scenarios
west east africa experience high variability rainfall expected increase climate change results fluctuations water availability food production socioeconomic activities water harvesting storage mitigate adverse effects rainfall variability past studies shown investments water storage guided environmental health considerations increased availability open water surface may increase transmission water related diseases demonstrated schistosomiasis associated small reservoirs burkina faso malaria ethiopia around large dams small dams water harvesting ponds concern rush develop water harvesting storage climate change adaptation may increase risk already vulnerable people cases canceling benefits greater water availability taking health issues account participatory approach planning design management rainwater harvesting water storage well considering full range water storage options would enable better opportunities enhancing resilience climate change vulnerable populations sub saharan africa
many hospitality consumption experiences shared fellow consumers acquaintances friends family members yet research examining impact fellow consumers presence consumers donation behaviors scant bridge gap current research examines presence fellow consumers influences consumers donation behaviors restaurant setting results experiment reveal impact fellow consumers presence depends two factors observability donation donation appeal type specifically found act donating unobservable others donation appeal highlights self benefits presence fellow consumers drives individuals exhibit favorable attitude higher levels donation intention conversely act donation observable others donation appeal portrays benefits presence fellow consumers makes individuals exhibit less favorable attitude lower levels donation intention furthermore mediation analyses show anticipated emotional benefits underlying psychological mechanism explaining effects discuss theoretical contributions managerial implications findings well limitations opportunities future research
bacteriorhodopsin considered important biomolecule biochemical technology oriented studies modeling functionality bacteriorhodopsin sensors extensively studied studies lack analysis errors present measurements impacts errors photoelectric measurements mostly unknown paper discuss errors caused transimpedance amplifier photocurrent measurements dry bacteriorhodopsin sensor information especially useful evaluating reliability photocurrent measurements
botnets one leading threats network security nowadays used conduct wide variety malicious activities including information theft phishing spam mail distribution distributed denial service ddos attacks among various forms botnet dga based botnets utilize domain generation algorithm dga avoid detection one disruptive difficult detect botnets dga used generate huge list candidate command control server domains bot attempts connect active server querying dns server turn dga based botnets highly elusive difficult detect using traditional defensive mechanisms therefore high survivability accordingly study proposes dga based botnet detection scheme designated dbod based analysis query behavior dns traffic proposed scheme exploits fact hosts compromised dga based malware query sets domains domain list queries fail since limited number domains actually associated active feasibility proposed method evaluated using dns data collected education network environment period months results show dbod provides accurate effective means detecting existing new dga based botnet patterns real world networks elsevier ltd rights reserved
paper presents method tracking textureless object undergoes elastic deformations using point cloud data provided rgb sensor real time solution expected useful enhanced manipulation humanoid robotic systems especially case pizza dough ideally manipulated pizza chef robot tracking framework relies prior visual segmentation object image segmented point cloud registered first rigid manner non rigidly fitting mesh based finite element method model elasticity geometrical point point correspondences compute external forces exerted mesh system evaluated synthetic real data integrating manipulation experiments rodyman humanoid robotic platform elsevier rights reserved
integration solar energy electricity market faces challenges related time varying nature energy coming sun use energy storage emerges technological solution problems opens new possibilities integration photovoltaic plants electrical market paper addresses problem integration plants electricity market providing solution optimal scheduling allows plant participate daily intraday markets order perform proper scheduling good estimation energy prices paramount importance paper proposes also price forecast algorithm provides prices one day horizon based price historical data meteorological information development scheduling strategy carried using model predictive control mpc taking account operational constraints mpc techniques allow maximizing economic benefit plant manipulating energy stored extracted batteries results application price forecasting approach scheduling strategy simulated plant located seville spain presented weather data electricity prices publicly available supplied spanish system operator elsevier ltd rights reserved
identifying network traffics early stages accurately important network management security recent years studies devoted find effective machine learning models identify traffics packets early stage paper try build effective early stage traffic identification model applying flexible neural trees fnt three network traffic data sets including two open data sets used study first extract packet level features statistical features first six continuous packets six noncontinuous packets flow packet sizes applied packet level features statistical features average standard deviation maximum minimum selected eight classical classifiers employed comparing methods identification experiments accuracy true positive rate tpr false positive rate fpr applied evaluate performances compared methods fnt outperforms methods cases identification experiments behaves well tpr fpr furthermore show selected features optimal tree result experiment result shows fnt effective early stage traffic identification
researchers concerned identifying risk protective factors associated adolescents involvement cyberharassment one factor parental mediation children electronic technology use little attention given different parental mediation strategies instructive restrictive viewing relate adolescents cyberharassment cyberbullying cybertrolling perpetration victimization gender might impact associations end present study examined moderating effect gender longitudinal association parental mediation strategies adolescents cyberharassment involvement focus examined using sample female adolescents grade united states association restrictive mediation cybervictimization positive girls compared boys relationship instructive mediation cybervictimization negative girls boys findings underscore importance considering parents adolescents cyberharassment involvement elsevier ltd rights reserved
development nanotechnology gives new possibilities fabrication different ray optical elements present results focusing properties compound silicon linear zone plate first second orders compound silicon linear fabricated electron beam lithography lift technology zps structures etched ion plasma deep linear first second orders fabricated ray radiation kev energy focal distance entire aperture width outermost zones first second orders number first second order zones experiment performed beam line blxu spring japan synchrotron radiation facility experimentally theoretically investigations done ray energy kev kev wavelength radial distribution intensity determined convolution zone plate transmission function kirchhoff propagator par axial approximation algorithm based fft procedure studied means computer programming simulation
objetive assess association emotional intelligence academic stress levels students faculty human medicine university san martin porres subsidiary norte material methods descriptive cross regular students enrolled studied professional school human medicine academic semester inventory applying bar emotional intelligence academic stress inventory sisco results among frequent interpersonal intelligence average intrapersonal intelligence low adaptability low stress management occurred frequently low level overall mood average regard frequency academic stress presented students sometimes followed almost always encontro association emotional intelligence academic stress conclusions conclude relationship emotional intelligence academic stress levels medical students universidad san martin porres filial norte
many biological materials readily modulate mechanical properties shape interacting water surrounding environment essential high performance application contrast typical inorganic materials metals change strength shape without involving thermal mechanical treatments introducing nano scale porous structure exploiting simple physical concept watercapillarity nanopores report dead metal transformed smart material water responsive properties demonstrate apparent strength volume shape nanoporous modulated situ dramatically recoverably response water dipping partial drying amplitude strength modulation reaches mpa nearly yield strength initial state approach also leads reversible length change nanoporous large reversible bending motion layer strip tip displacement similar may used actuation method simple effective occurring situ ambient conditions requiring external power analogous biological materials findings may open novel applications many areas micro robotics bio medical devices
model free hysteresis loop analysis hla method structural health monitoring shm significant advantages traditional model based shm methods require suitable baseline model represent actual system response paper provides unique validation experimental reinforced concrete building calibrated numerical model delineate capability model free hla method adaptive least mean squares lms model based method detecting localizing quantifying damage may visible observable overall structural response results clearly show model free hla method capable adapting changes structures transfer load demand across structural elements time multiple events different size however adaptive lms model based method presented image greater spread lesser damage time story baseline model well defined finally two algorithms tested simpler hysteretic behaviour typical steel structure quantify impact model mismatch baseline model used identification actual response overall results highlight need model based methods appropriate model capture observed response order yield accurate results even small events structure remains linear elsevier ltd rights reserved
osteoporosis related bone fractures increasing global burden ageing society areal bone mineral density assessed dual energy ray absorptiometry dexa clinically accepted used method sufficient assess fracture risk individually finite element modelling shown improvements prediction fracture risk better abmd dexa practical widespread clinical use aim study develop adaptive neural network ann based surrogate model predict femoral neck strains fracture loads obtained previously developed population based model surrogate model performance assessed simulating two loading conditions stance phase gait fall surrogate model successfully predicted strains estimated level gait load case fall load case moreover ann model based three measurements obtainable clinics femoral neck length level gait maximum femoral neck diameter fall femoral neck bone mass body weight able give reasonable predictions strain metrics estimated femoral neck fracture load overall surrogate model potential clinical applications based simple measures geometry bone mass derived dexa images accurately predicting model outcomes advantages models quicker easier perform crown copyright published elsevier ltd rights reserved
studies exploring ways gender structures family experiences americanborn children immigrants less attention gender shapes later views ethnicity culture based interviews korean chinese taiwanese americans new york new jersey metropolitan area article examines different ways second generation children learn interpret pass cultural values family traditions adulthood family roles center roles leaders carriers family name male heirs sons especially oldest sons fulfill filial obligations relatively orthodox nonengaging cultural practices although restrictive threaten personal goals privileged status however daughters must negotiate emotionally burdensome expectations responsibilities preserving family honor acting family caretakers juggling multiple responsibilities thus tend create subtle self empowering emotionally engaging ways interpreting preserving parents expectations family culture argue gendered ways daughters sons taught practice cultural values protect family honor significant bearing later views ethnicity culture complex ways transcend generational divide
laser ablation liquid lal received considerable attention last decade gradually becoming irreplaceable technique synthesize nanocrystals fabricate functional nanostructures offer effective solutions challenges field nanotechnology goal review offer comprehensive summary recent developments lal nanocrystal synthesis nanostructure fabrication first introduce fundamental processes microsecond nanosecond femtosecond lal active species act differently plasma cavitation bubbles droplets different lal processes second variety lal based techniques nanomaterials synthesis processing presented electric magnetic temperature field lal well electrochemically assisted lal pulsed laser deposition liquid laser writing nanopatterns liquid third new progress lalgenerated nanomaterials described fourth emphasize five applications lalgenerated nanomaterials emerged recently fields optics magnetism environment energy biomedicine finally consider core advantages lal limitations lal corresponding solutions future directions promising research area author
cases fungal infection bloodstream rapid species identification crucial provide adapted therapy thereby ameliorate patient outcome currently commercial sepsityper kit sodium dodecyl sulfate sds method coupled malditof mass spectrometry commonly reported lysis protocols direct identification fungi positive blood culture vials however performance two protocols never compared clinical samples accordingly performed two step survey two distinct panels clinical positive blood culture vials identify efficient protocol establish appropriate log score cut validate best method first compared performance sepsityper sds protocols clinical samples monomicrobial samples mass spectrometry values significantly higher sds protocol sepsityper method especially best score four deposited spots considered next established cut accurate identification based specimen dna sequence data using cut isolates correctly identified species level sds sepsityper protocols respectively second arm survey validated sds protocol additional panel clinical samples ninety two monomicrobial samples correctly identified species level median overall data suggest sds method yields accurate species identification yeasts sepsityper protocol
aim study evaluate effectiveness tolerance tendency enhancement program ttep prepared enhance tolerance tendency reduce bullying level fifth grade students pretest posttest follow test control placebo group experimental design used research study carried sample fifth grade students experimental group placebo group control group data used study obtained tolerance tendency scale tts peer bullying scale pbs wilcoxon signed ranks kruskal wallis tests used analyze data results study showed significant change post tests placebo control experimental groups favor experimental group said ttep enhance tolerance tendency reduce bullying level experimental group besides ttep applied experimental group understood permanent effects tolerance tendency conclusion part study suggestions recommendations provided counseling practices researchers light findings
every year smaller cheaper precise technologies ambient intelligence emerging one particularly gaining lot traction past year indeed due low cost long battery life called bluetooth beacons used wide range applications including indoor localization human team using gather statistics room occupancy health monitoring paper consider beacons signals time series define new spatial feature generalize across configuration floor plan beacons number etc feature used distinguish positioning information resident results leave one experiments various floor plans shows promising results
electrical generator certain device power source servo system electrical systems traditional detection methods electrical generator usually need buy manufacture great deal special device items fact difficult carry operation processes complicated low automatization degree article hardware software design projects based virtual instrument technology detection system deeply researched based labview electrical parameter detection technology serial port communication technology hardware system intellectualized electric quantity detection modules used isolation adjustment units making cost low security high serial port transport used data communication general computers software system lab view used developing platform data acquisition detection designed based general serial port driver program labview system signals saved data log files labview detection process data monitored time detection data reported excel files activex technology detection system greatly develop detection efficiency electrical generator device also reduce developing cost detection system
rheumatoid arthritis associated osteoporosis quantitative computed tomography qct capable assessing bone density composition found lower bone density compared controls age duration influenced bone density qct may useful assess bone metabolism associated generalized periarticular osteoporosis addition dxa determines areal bone mineral density bmd peripheral qct also detects volumetric bmd qct differentiates total trabecular cortical bmd compared dxa qct patients healthy controls bmd female patients age matched healthy female controls assessed dxa qct forearm ultradistal region also performed densitometry data correlated age disease duration disease activity serum crp anti ccp levels total bone density versus attenuation versus trabecular density versus attenuation versus cortical density versus attenuation versus significantly lower lumbar femoral neck bmd well scores significantly lower versus controls cases total cortical qct attenuation density associated age presence combination contrast trabecular density attenuation affected presence disease age also total trabecular cortical density determined qct significantly correlated lumbar femoral neck bmd measured dxa finally anti ccp seropositivity associated lower trabecular density attenuation dxa qct may suitable study bone metabolism areal bmd determined dxa may correlate volumetric bone density measured qct moreover trabecular osteoporosis may associated underlying autoimmune inflammatory disease cortical osteoporosis may rather age related
work presents parallel approach kinetic monte carlo kmc algorithm using distributed memory architecture resulting computer software tested conducting crystal growth simulations barite face execution times simulated times crystallization velocities compared shared memory parallel kmc software mmonca finally approximate crystal growth simulation performed compared atomic force microscopy crystal growth experiments capability approach demonstrated significant reduction parallel overhead achieved comparing shared memory parallel version software distributed memory approach achieves increase memory resources enough perform simulations lattice sizes allowing study larger structures shared memory sequential implementations approach used large scale simulations take advantage distributed memory architecture improvements needed parallel kmc faster serial kmc small scale simulations kmc algorithm used able adequately simulate two dimensional nucleation large areas barite faces
proposed effective machine learning method analyze multimedia content addressing gesture event detection recognition machine learning method based well studied techniques procrustes analysis combination local global representations linear shape model application smart virtual keyboard paper address gesture event detection specially fingertip gesture detection get smart advanced usage technology modern vision keyboard could good next generation replacement smart remote control economical need physical object like traditional keyboard remote control energy resources like batteries information demonstrations proposed keyboard accessed http video minelab mcaoged
previously observed microrna mir significantly increased serum patients acute ischemic stroke present study determine whether mir antagomir protect cerebral ischemia reperfusion injury elucidate underlying mechanisms middle cerebral artery occlusion mcao operated male sprague dawley rats mir antagomir significantly decreased neurological deficit scores infarct volumes neuronal injury furthermore mir antagomir markedly reduced malondialdehyde mda content restored superoxide dismutase sod activity increased expression myeloid cell leukemia mcl cell lymphoma bcl decreased expression bax ischemic cortex cells mir inhibitor increased mcl bcl expression provided protection glutamate induced apoptosis oxidative damage evidenced decreased lactate dehydrogenase ldh release enhanced sod activity notably luciferase reported assay proved mcl target gene mir conclusion data indicates neuroprotective effects mir antagomir cerebral injury associated inhibition apoptosis oxidative stress suggesting potential therapeutic target ischemic stroke
gastrointestinal health regard gut microbiome rapidly emerging field many key components driving emergence fibre prebiotics probiotics dietary components play critical role maintaining healthy gut microflora fibre long appreciated influential role cardiovascular disease glycaemic control weight management various physiological mechanisms prebiotics shown play influential role irritable bowel symptoms disease colon cancer cardiovascular disease overall digestive health together various types fibres prebiotics targeted synthesised influence gut microbiome specifically lactobacillus bifidobacterium populations lactobacillus spp bifidobacterium spp common markers gut health shown regulate inflammation gastrointestinal tract alleviate irritable bowel syndrome symptoms stimulate immune functions aid mineral absorption produce little gas known carcinogenic substances probiotics also shown display many pro health components include many species bacteria outside commonly utilised lactobacillus bifidobacterium populations dietary components defined scientific political arenas play critical role success gut health field moving forward key changes administrative definitions requirements dietary components influence consumption awareness understanding key influential components purpose review provide current accepted definitions fibre prebiotics probiotics well introduce key scientific studies describing health benefits components well current health claims
intensive agricultural systems mediterranean greenhouses monitoring soil nutrient salt status essential optimising vegetable production minimising soil water pollution work analyses dynamics electrical conductivity ecss nutrient concentration soil solution collected simultaneously various zero tension lysimeters suction cup tension lysimeter throughout two greenhouse tomato crops ecss obtained zero tension lysimeters funnel plate lysimeter generally lower suction cup irrespective soil depth moreover soil solution concentration potassium calcium magnesium sodium chloride sulphate obtained funnel lysimeter fullstop generally lower suction cup throughout cycles clear differences found nitrate concentration depth cycle depth one overall appears soil solutions collected suction cup funnel lysimeter represent different soil solution status processes funnel lysimeter collects freely draining soil solution may therefore provide better information movement elements soil horizons whereas suction cup sample soil solution soil pores longer residence times especially unsaturated flow conditions might represent better available element concentrations plant nutrition studies differential response found nitrate could due fact mobile element within soil soil water matric potential slightly higher soil zero tension lysimeters throughout cycle devices might alter soil solution movement water nutrient availability hand general good fit found soil solution concentration nitrate potassium calcium sodium measured rapid analysis system laqua measured using reference laboratory method rapid system combination suction cup facilitate farmers control soil nutrient salt status elsevier rights reserved
traditional gender roles sex scripts way female sex offenders portrayed media may lead misconceptions commit sexual offenses sexual crimes women may unnoticed unreported general lack awareness females commit crimes data nebraska annual social indicators survey used determine whether public perceives women capable sex offenders perceived causes female sex offending traditional focus male sex offenders researchers media politicians addition gender stereotypes introduces possibility group differences men women perceptions female sex offenders consequently two secondary analyses conducted tested group differences public perception whether females commit sex offenses explanations selected females sexually offend findings suggest public perceive women capable sex offenders although group differences causal attributions female sex offending
novice students participated lab study learned fundamentals computer programming python using self paced computerized learning environment involving min scaffolded learning phase min unscaffolded fadeout phase students provided affect judgments approximately points every course viewing videos faces computer screens recorded learning session results indicated engagement confusion frustration boredom curiosity frequent affective states anxiety happiness anger surprise disgust sadness fear rare confusion frustration curiosity engagement identified two frequently occurring pairs affective states analysis affect dynamics indicated reciprocal transitions engagement confusion confusion frustration one way transitions frustration boredom boredom engagement considering interaction events tandem affect revealed constructing code central activity preceded followed affective state confusion frustration followed errors preceded hint usage curiosity engagement followed reading coding analysis affect learning relationships partialling control variables scholastic aptitude hint usage indicated boredom frustration negative correlated learning transitions confusion frustration frustration confusion boredom engagement positively correlated learning implications results theory affect incidence dynamics design affect aware learning environments discussed
propose novel design optical buffer generate slow light based delay time framework nonlinear waveguide investigate propagation solitons microring resonators dynamical control slow light solitons realized via controlling fields generated bright soliton gaussian pulse nonlinear dependence velocity signal controlling field analytically described buffering effect achieved slowing optical signal using external control light source vary dispersion characteristic medium via microring resonators graphical approach signal flow graph method used derive optical transfer functions domain filters characteristics optical buffer devices including transmittance time delay drop port simulated simulated results show criteria achieving slow light semiconductor microring resonators finally output signal shows delay time rate propagation semiconductor microring resonators society photo optical instrumentation engineers spie doi
objective purpose study examine effects sexual assault victimization later typical alcohol use alcohol related consequences among young sexual minority women smw method data collected annual assessments national sample women identified lesbian bisexual years old baseline marginal structural modeling analytic approach accounts time varying confounding use inverse probability weighting used examine effects sexual assault severity none moderate severe typical weekly number drinks consumed number alcohol related consequences year later well year cumulative sexual assault severity alcohol outcomes month follow results findings showed compared experiencing sexual assault severe sexual assault prior assessment associated higher number typical weekly drinks count ratio confidence interval higher number alcohol related consequences effects attenuated comparing moderate sexual assault however linear trend across sexual assault categories statistically significant outcomes also effects cumulative levels sexual assault severity years increased typical drinking alcohol related consequences end follow conclusions sexual assault may important cause alcohol misuse among smw findings highlight need strategies reduce risk sexual assault among smw
till evidence illustrates prevalence predictors metabolically healthy obesity mho rural areas china objective study firstly examine prevalence mho rural areas china identify contributing determinants mho secondly comprehensively investigate different characteristics mho metabolically unhealthy obesity muo conducted population based cross sectional study participants obesity rural liaoning province obesity defined bmikg metabolically healthy defined metabolic syndrome prevalence mho significantly decreased advancing age female group however significant tendency advancing age male group independent determinant factors mho age years odds ratio non current smoking pre menopause non hyperuricemia whereas race gender diet score current drinking marriage sleep duration hyperhomocysteinemia levels physical activity annual income educational status significant contributors conclusion found age years non current smoking pre menopause non hyperuricemia identified independent determinant factors mho population
field wind energy electrical generator solutions converged small number technologies specific technical economic reasons paper investigates whether similar rationale exists within field oscillating water column wave energy converters suitability otherwise various generator options offshore marine environment examined detail generator configuration modeled annual energy output typical wave climate assessed consideration given impact speed control energy output finally conclusions drawn regarding relative suitability different generator options
background peach non specific lipid transfer protein pru primary sensitizer fruits responsible severe reactions mediterranean area peach allergy frequently associated allergies peanut therefore important assess specific immunotherapy pru could affect peach peanut tolerance objectives evaluate peach peanut desensitization immunological changes year pru sublingual immunotherapy slit patients systemic allergic reactions peach peanut methods forty eight peach allergic patients treated slit non treated monitored months treated patients subclassified peanut allergic group sensitized group tolerant group slit effect evaluated skin prick test spt reactivity food challenge immunological changes evaluated monitoring sige sigg levels basophil reactivity results year slit weal area spt significantly decreased significant increase peach threshold treated patients observed patients group showed significant decrease peanut spt weal area increase peanut threshold immunological changes observed treated patients significant decrease sige parallel increase sigg sigg sige basophil reactivity pru ara conclusions clinical relevance year pru slit induces desensitization immunological changes peach also food allergens relevant induction severe reactions peanut
ability retrieve accurate information relational databases requires proficiency structured query language sql spite declarative nature teaching learning sql complex data retrieval tasks remains challenge cognitive load theory clt explains interactions working long term memories acquiring complex knowledge skills used clt identify two instructional interventions expected improve query writing performance conditions high low query code complexity first presented information requests pseudo sql language rather manager english clarify relevant elements data model second provided query template intermediate problem solving step prior coding conducted experiment student participants repeated measures design request language either pseudo sql manager english task included query template task either low high query code complexity results show request language template usage significantly affected query writing performance different situations pseudo sql requests significant positive impact query accuracy less complex queries impact complex queries hand using query template prior writing sql code improved task performance complex queries less complex queries discuss implications findings instructional design future research
propose framework understanding multimodal joint work turn construction face face interaction using concepts conversation analysis nonverbal communication gesture studies qualitative analysis face face interaction observe collaboratively joint work participants produce moves within current speaker turn allow deal possible moves could compromise projectable trajectory interaction progress working micro level interaction propose framework allows better understanding turn collaboratively produced levels sequence organization produced order achieve desired social agreement outcome elsevier rights reserved
research demonstrated importance early family characteristics quality caregiving children later mental health information however needed role holistic family systems specific child related socioemotional mechanisms study conceptualize families dynamic family system types consisting marital parenting trajectories transition parenthood first examine early family system types predict children anxiety depression peer exclusion emotion regulation second test whether couples infertility history family related contextual factors moderate effects family system types child outcomes third test whether children emotion regulation peer exclusion mediate effects family system types anxiety depression participants families representing cohesive distant authoritative enmeshed discrepant family types identified basis relationship autonomy intimacy pregnancy child age months children anxiety depression emotion regulation peer exclusion assessed age years structural equation modeling showed distant enmeshed discrepant families similarly predicted children heightened anxiety depression infertility history parental education parity moderated associations certain family system types child outcomes finally emotion regulation peer exclusion common mediating mechanism distant enmeshed families children depression results emphasize importance early family environments children emotion regulation development internalizing psychopathology
background frequent mild head injuries concussion along presence headache may contribute persistence concussion symptoms methods study acute effects recovery mild head injuries frequency injuries headache behavior trigeminal allodynia assessed using von frey testing one week injury histopathological changes trigeminal pain pathway evaluated using western blot elisa immunohistochemistry results decreased recovery time combined increased mild closed head injury chi frequency results reduced trigeminal allodynia thresholds compared controls repetitive chi group highest injury frequency showed greatest reduction trigeminal thresholds along greatest increased levels calcitonin gene related peptide cgrp trigeminal nucleus caudalis repetitive chi resulted astrogliosis central trigeminal system increased gfap protein levels sensory barrel cortex increased number microglia cells trigeminal nucleus caudalis conclusions headache behavior rats dependent injury frequency recovery interval mild head injuries worsening headache behavior repetitive mild head injuries concomitant increases cgrp levels presence astrocytosis microglia proliferation central trigeminal pathway signaling neurons proliferating microglia trigeminal pain system may contribute initiation acute headache concussion traumatic brain injuries
developing countries base metal residues abandoned tailing ponds impoundments increasingly used construction material without control engineering basis environmental concern uncontrolled reuse mine tailings may constitute new form pollution risks humans ecosystems metal leaching therefore aim current study assess mine drainage metal mobility geochemical behavior two abandoned mine tailings commonly used upper moulouya region eastern morocco fine aggregates mortar preparation detailed physical chemical mineralogical properties subsequently evaluated context developing appropriate alternative reuses replace conventional disposal limit weathering exposure obtained results showed tailings contain relatively high quantities residual metals metalloids lead ranging major pollutant however mineralogical investigations revealed presence abundant neutralizing minerals low sulfide content influence mine drainage geochemistry subsequently lower metals mobility fact leachate analyses weathering cell kinetic tests showed neutral conditions low sulfide oxidation rates according results tailings used construction material upper moulouya region low generating potential contaminated effluents reuse aggregates may constitute sustainable alternative method efficient tailing management
background allergen specific immunotherapy ait safe effective treatment allergic rhinitis allergic asthma however patient non compliance major barrier achieving optimal outcomes objective determine level compliance among patients using ait identify factors associated non compliance methods retrospective analysis using questionnaires conducted study compliance among patients allergic rhinitis without asthma began ait results compliance rates among patients subcutaneous immunotherapy scit among sublingual immunotherapy slit mean durations treatment scit slit months respectively common causes non compliance among patients scit frequency injections duration treatment commuting allergy center reasons non compliance among patients slit related inconvenience improvement without treatment perception poor efficacy conclusion compliance ait low years higher among patients scit among patients slit reasons non compliance include difficulty adjusting treatment protocols perception efficacy low patient education regarding treatment course slow effect well need close follow effectively prevent treat adverse reactions important factors improving compliance treatment outcomes
background schedule affective disorders schizophrenia school age children sads one commonly used standardized diagnostic interviews child adolescent psychiatry validity studies scarce limited concurrent validity measures clinical diagnoses aims evaluate sads interview outpatient child adolescent psychiatry cap setting longitudinal expert data lead procedure methods cap residents performed sads interview revised version containing new pdd section clinically referred outpatients years old parent consensus lead diagnosis two senior clinicians years later based clinical records including sads subsequent information assessments information teachers informants outcome treatment least three visits sads results predictive validity sads lead diagnoses good excellent broader categories anxiety disorders depressive behavioural tic disorders good adhd good moderate autism spectrum disorders bipolar psychotic eating disorders analysed conclusion sads diagnoses elicited interview child one parents one occasion excellent validity major child psychiatric disorders adhd reliably diagnosed one visit clinicians need stay alert possible undiagnosed adhd diagnosing autism sads version one visit advisable
design fabrication testing student competition based racing car presented paper competition encourage students compete demonstrate practical abilities develop mini race car design guideline based specifications set organizer universiti teknikal malaysia utem formula varsity car design car carried using catia solid modelling system car fabricated one laboratory mechanical manufacturing engineering universiti putra malaysia car tested performance two types test conducted static test track test
background objectives socially anxious individuals elicit less positive reactions interlocutors non anxious individuals evidence distinctive social anxiety linked behaviour deficit explain finding sparse investigated whether socially anxious individuals engage less joint action process promotes rapport usually arises spontaneously conversation partners actively attend conversation methods study participants high fear negative evaluation low fear negative evaluation conversed peer study simulated cognitive impact anxiety linked threat focus non anxious participants via partial distraction task measured social consequences results study listeners high fear negative evaluation made fewer collaborative contributions partner anecdote index joint action study non anxious distracted listeners showed behavioural pattern fewer collaborative responses less well liked conversation partners compared non distracted listeners limitations coded one marker joint action future research identify indices connectedness partners addition studies conducted small groups university students future research conducted larger samples selected basis social anxiety fear negative evaluation alone conclusions together findings indicate socially anxious individuals engage less shared task conversation behaviour attracts less positive responses conversation partners published elsevier ltd
major axis disorders including major depressive disorder mdd bipolar disorder anxiety disorder schizophrenia associated host aberrations way social stimuli processed face perception tasks often used neuroimaging research emotion processing healthy patient populations date exists mounting body evidence behavioral within brain indicating emotional faces compared neutral faces processed abnormally axis disorders relative healthy control groups use neutral faces baseline control condition predicated assumption neutral faces processed way hcs individuals major axis disorders paper existing fmri studies examining way neutral faces processed groups axis disorders involving socioaffective perception reviewed reviewing available studies consistent pattern results demonstrated disorders associated abnormal frontolimbic activity response neutral faces particular within amygdala prefrontal regions dorsolateral prefrontal cortex dlpfc anterior cingulate cortex acc compared groups specifically increased amygdala activation consistently reported response neutral faces anxiety disorders schizophrenia abnormal medial pfc activity reported patients mdd patients exhibit decreased activity dlpfc acc relative hcs addition specific suggestions overcome obstacles new research additional analyses discussed
objectiveswhile cognitive impairment frequently reported hiv positive individuals historically associated poorer functional outcomes associations cognitive impairment patient reported outcome measures proms contemporary cohorts unclear methodswe tested cognitive function using computerized battery cogstate hiv positive hiv negative individuals aged years participating pharmacokinetic clinical observations people fifty poppy study participants completed questionnaires detailing physical mental health short form health survey cognitive function european aids clinical society eacs questions activities daily living lawton instrumental activities daily living iadl depression patient depression questionnaire phq centres epidemiologic studies depression scale ces falls sexual desire cognitive impairment defined using frascati criteria global deficit score gds multivariate normative comparison mnc hiv positive group classification performances different definitions cognitive impairment dichotomized questionnaire results calculated resultsthe prevalence cognitive impairment hiv positive group gds frascati mnc diagnosed hiv associated dementia general associations cognitive impairment proms weak regardless definition used mean statistics gds mnc frascati associations similar using global score define cognitive impairment summary health scores lower significantly cognitive impairment identified using mnc mental health physical health conclusionsthe associations cognitive impairment proms weak possibly impairment mild therefore largely asymptomatic work needed elucidate clinical implications cognitive impairment hiv disease
pro active message delay tolerant networks dtns based usage mobile code obtain messages contain routing code architecture allows applications use network different ways keystone type heterogeneous network collection contextual application related information stored every node accessed messages routing code access information must protected order make whole architecture feasible operation network secure attacks information poisoning avoided propose identity based access control system pro active message dtn based tools available dtn networks like symmetric key encryption hashes system grants confidentiality integrity contextual information solves question messages needing use distributed information stored nodes route properly proof concept identity based access control certain kind application demonstrates feasibility proposal comparison proposal access control systems shows identity based access control system fits well special characteristics pro active message dtn copyright john wiley sons ltd
modeling cancerous healthy homo sapiens colon gene using electrical network proposed study behavior paper individual amino acid models designed using hydropathy index amino acid side chain phase magnitude responses genes examined screen cancer healthy genes performance proposed modeling technique judged using various performance measurement metrics accuracy sensitivity specificity etc network model performance increased frequency analyzed using receiver operating characteristic curve accuracy model tested colon genes achieved maximum mhz frequency
aim evaluate retinal vessel diameters patients migraine optical coherence tomography oct methods cross sectional study eyes patients diagnosis unilateral migraine attack free period age sex matched control subjects included migraine patients divided migraine attacks per month group migraine attacks per month group subjects underwent complete ophthalmological neurological examinations measurements retinal vessel diameters choroidal thickness examined spectralis oct results mean diameters arteries eyes headache side control group migraine attacks per month migraine attacks per month group optic disk raster respectively steady decline raster last measurement point respectively retinal artery diameter measurements significantly increased migraine attacks per month patients four five measured points compared control group migraine attacks per month patients measured points compared control group migraine attacks per month patients compared control group
compare diagnostic efficacies mode ultrasound strain elastography contrast enhanced ultrasound ceus combination modalities breast lesions size january october inpatients sub centimetre breast lesions categorised rads breast imaging reporting data system ultrasound included ceus performed evaluate lesion diagnostic performances different ultrasonic modalities compared diagnostic efficacies rads rating systems also compared pathology findings used reference standard specificities ceus tumour differentiation respectively sensitivities ceus respectively area curve auc receiver operating characteristic roc curve original rads rads combined rads combined ceus rads combined ceus best combination rads combined ceus evaluating sub centimetre breast lesions ceus could increase diagnostic specificity retaining high sensitivity compared mode ultrasound aeuro cent evaluating breast lesions ceus could increase diagnostic specificity aeuro cent ceus offer alternatives biopsy possibly allow shorter interval follow ups aeuro cent rads combined ceus exhibited best diagnostic performance
design problem static output feedback controller multivariable proportional integral derivative pid controller investigated linear time invariant systems lti first static output feedback stabilization problem taken consideration iterative linear matrix inequality ilmi algorithm developed synthesis controller second choosing multivariable pid control law whole system transformed new augmented system represented form static output feedback control system method allows convert multivariable pid controller design problem static output feedback synthesis problem thus proposed ilmi algorithm well utilized design multivariable pid controller two numerical examples presented illustrate practical application developed methodologies
sustainability building projects become great concern construction professionals number different green building rating systems developed help ensure building projects designed built using strategies intended minimize eliminate impacts environment united states although leadership energy environmental design leed green building rating system widely accepted national standard sustainable building design assessment green buildings challenging time consuming owing complicated process green building rating process could accelerated facilitated using computer technology building information modeling bim innovative new approach building design engineering construction management widely used architecture engineering construction industry enable green building rating building design bim applications building information must represented way knowledge contained leed green building criteria extracted bim model support assessment paper building knowledge framework representing leed green building criteria presented proposed framework implemented bim platform obtain automated tool rating green building design development automated green building rating system results implementation discussed american society civil engineers
comparing strings assessing similarity basic operation many application domains machine learning information retrieval natural language processing bioinformatics practitioner choose large variety available similarity measures task emphasizing different aspects string data article present harry small tool specifically designed measuring similarity strings harry implements similarity measures including common string distances string kernels levenshtein distance subsequence kernel tool designed efficiency mind allows multi threaded well distributed computing enabling analysis large data sets strings harry supports common data formats thus interface analysis environments matlab pylab weka
motivation students course different subjects plays important role acquire corresponding knowledge one idea enhance lack motivation subjects applications real live show applications teaching period real applications shown relatively easy way subject called theory structures given master industrial technology engineering topic considered continuation subject elasticity strength materials provides fundamental knowledge deal different techniques structural analysis aim course learn different methods allow determination stress strain states different structural components structures subjected external actions stress strain states fulfill established requirements according corresponding normative two hours long workshop called structural topology optimization introduced course traditional design process starting point usually previous defined distribution connected bars makes structure analytical methods dimensions cross sections elements obtained previous defined domain obtained experience trial error methods introducing topology optimization design process starting point simple general design domain compatible supports loads sequence optimal material distribution structure obtained mathematical programming
population continues experience alarmingly high rate unintended pregnancies impact individual families society alike lack effective contraception accounts unintended pregnancies along incorrect use contraceptives common reversible contraceptive method used united states oral contraceptive pill significant failure discontinuation rates use long acting reversible contraceptive larc methods increasing recent years efforts educate providers patients women likely use larc methods barriers access cost removed uptake use larc methods would allow markedly reduced contraception failure rates higher user satisfaction thus higher continuation rates seen current contraception use promoting use larc methods important strategy improving individual public health outcomes reducing unintended pregnancies pharmacist role family planning expanding contribute efforts although knowledge regarding larc studied among pharmacists knowledge deficit exists among health care professionals general thus pharmacist education training include larc methods along contraceptives american college clinical pharmacy women health practice research network advocates pharmacist role use safe highly effective larc methods roles include educating patients informing providers facilitating access providing referrals modifying institutional procedures encourage provision larc methods
paper mathematical model describing blood flow deforming porous channel solved numerically blood flow considered micropolar fluid flow governing system nonlinear partial differential equations reduced nonlinear system ordinary boundary value problem using suitable similar transformations efficient numerical technique based integration radial basis function process irbf coupled collocation method performed approximate solution boundary value problem numerical results presented figures tables demonstrate efficiency accuracy convergence method moreover effects various embedded model parameters expansion ratio slip coefficient others flow velocity profiles explained graphically
purpose review review provides update new interleukin cytokine family members inflammatory diseases focus recent findings concerning family members different expression patterns recent findings cytokines known involved many different inflammatory autoimmune diseases latest family members shown differently regulated course disease studies patients suffering inflammatory diseases revealed cytokines upregulated serum well inflamed tissue epithelial cells infiltrating peripheral mononuclear blood cells serve source cytokines triggering different outcomes results could confirmed different mouse models vitro vivo studies summary involved pathogenesis inflammatory diseases psoriasis rheumatoid arthritis gout systemic lupus erythematosus well crohn disease thereby acts proinflammatory triggering inflammatory mediators contrast upregulated counteract understanding imbalance family crucial future therapeutics
recent data indicate large disparities use opioid analgesics control breakthrough cancer pain btcp europe worldwide clear affordability key factor certainly one factors cultural differences overall awareness undoubtedly responsible work remains done overcome barriers use medications warranted prescribing medication btcp must considered time profile different chronic persistent pain best control background pain best achieved low dose extended opioid managing btcp rapid onset opioid providing good combination overall pain control lower opioid exposure notwithstanding efficacy greater attention needs paid inappropriate use opioids important evaluate patients potential opioid misuse including assessment risk factors aberrant drug taking behaviours must investigated institution several measures adopted patient population order prevent aberrant opioid induced behaviours adoption principles depending individual patient treatment setting undoubtedly help reduce risk developing aberrant behaviour related opioid use rescue medication btcp
mobile computing new computing technology developed mobile communication distributed computing technology analysis research interaction mobility improve system construction business restructuring quality management complex business process firstly calculus proposed basic language formalizing mobile communication based analysis redefinition interaction mobility sense structural congruence formal framework interaction mobility constructed defining general unit unit instance based mobility channels calculus last semantic correctness formal framework simulated derived according structured operational semantics process algebra
maze extension object specification language supporting specification development multi agent systems mas following recommendations agent oriented software engineering community supports three distinct levels abstraction macro level focusses system overall global behaviour independently agents system operate interact meso level focusses agent interactions iii micro level focusses operation individual agents object high level support component based specification well suited modelling mas complemented maze support action refinement facilitate top development process macro micro level number syntactic conventions aimed abstractly specifying low level mechanisms required dealing asynchronous communication timing constraints micro level latter shorthands existing object notation require redefinition object semantics paper provide overview maze illustrate use non trivial case study swarm robotic algorithm self assembly elsevier rights reserved
background fungal infections burn injuries one important factors morbidity mortality typically infections identified second week burns antibiotic therapy associated process also percentage burned body area important study aimed identify risk factors fungal infections pediatrics burn unit methods medical records patients hospitalized august august evaluated retrospectively parameters evaluated two groups burned total body surface area age use antibiotics antifungal treatments antibiotic treatments median days antibiotic treatments results twenty patients fungal infections patients using antibiotics bacterial infections fungal infections age insignificant fungal non fungal groups compared burn injury total body surface area risk factor also antibiotic treatment longer days risk factor conclusions forty percent burned total body surface area antibiotic treatment longer days important factors fungal infections
study modeling lagrangian systems multiple degrees freedom based system dynamics canonical parametric models require hoc derivations sometimes simplification computable solution hand due lack prior knowledge system structure modern nonparametric models machine learning face curse dimensionality especially learning large systems paper bridge gap unifying theories lagrangian systems vector valued reproducing kernel hilbert space reformulate lagrangian systems kernels embed governing euler lagrange equation lagrangian kernels show kernels span subspace capturing lagrangian projection inverse dynamics property model uses inputs outputs machine learning inherits structured form system dynamics thereby removing need mundane derivations new systems well generalization problem learning scratches effect learns system lagrangian simpler task directly learning dynamics demonstrate applied proposed kernel identify robot inverse dynamics simulations experiments results present competitive novel approach identifying lagrangian systems despite using inputs outputs
lack system level finite element model directly predict performance piezoelectric energy harvester connected interface circuits electric load work developed system level model piezoelectric strain energy harvesting system directly coupling finite element electrical circuits strain energy harvester seh macro fibber composite adhesively bonded composite beam simulations performed seh connected three circuits individually load resistor rectifier terminated load resistor iii rectifier terminated smoothing capacitor load resistor experimental tests carried validate simulation results good agreements observed simulated measured results developed model able predict performance energy harvesting system different circuit connected validated system level model used design optimization piezoelectric energy harvesting system investigating interactions energy harvester electrical circuits
paper parasitic resistance capacitance lateral nanowire field effect transistor nwfet studied detail parasitic components nwfet modeled extracted using technology computer aided design tcad simulation tool extraction results extension length turned dominant factor determining intrinsic gate delay single nanowire fet also trench contact structure stacked nanowire fet also investigated view parasitic constituents based extracted parasitic resistance capacitance optimal source drain extension length obtained considering two parasitic components inverse trend change extension length
objectives aim study systemically investigate risk subsequent irritable bowel syndrome ibs children antecedent allergic diseases population based case control study taiwan methods evaluated children age range years ibs age sex matched control subjects examined ibs odds ratios calculated children antecedent allergic diseases including allergic conjunctivitis allergic rhinitis asthma atopic dermatitis urticaria food allergy results children antecedent allergic diseases greater risk ibs control subjects among evaluated diseases highest adjusted odds ratio observed allergic rhinitis confidence interval allergic diseases adjusted odds ratios increased subjects girls children years older conclusions preschoolers history allergic disease increased risk subsequent ibs development upon reaching school age risk increased presence concurrent allergic disease higher clinical allergy burden
aim study discover genomic variations related variant creutzfeldt jakob disease vcjd susceptibility genome wide association analysis vcjd samples available world performed series vcjd patients controls included discovery stage best findings replicated independent population french vcjd cases post hoc analysis assess main results included french controls dutch controls sporadic creutzfeldt jakob disease cjd cases found genome wide significant variants tagging prnp two single nucleotide polymorphisms snps successfully replicated independent samples reached genome wide significance pooling discovery replication populations intronic variant myotubularin related protein gene mtmr specifically expressed central nervous system cns dephosphorylates phosphatidylinositol phosphate inositol bisphosphate intergenic region upstream neuronal pas per arnt sim domain containing protein gene npas regulatory gene belonging family transcription factors implicated memory seasonal affective disorder molecular clock mammalian forebrain proxy found regulate phospholipase delta gene plcd trans enzyme catalyzes hydrolysis phosphatidylinositol bisphosphate study reveals new genome wide significant markers vcjd outside prnp provides evidence supporting role phosphatidylinositol pathway vcjd susceptibility elsevier inc rights reserved
although recent laboratory tests showing promising progresses materials production technologies photovoltaic devices commercial modules show analogous impressive improvements therefore diagnostic approach able check current state health already installed systems well trend ageing assumes strategic importance scenario introduce thermography based diagnostics able provide detailed clear unambiguous information thanks computer aided investigation much deeper today available infrared analysis proposed approach allows numerical qualitative evaluation cell device part framework introduces methodology based two main analyses first one cell analysis studies single cell second one cluster analysis focuses attention groups cells framework also characterized preprocessing region interest extracted infrared image order focus successive processing analyses area part platform results shows cloud platform implementing workflow automatically generates comprehensive detailed report discusses also several significant cases study
interleukin novel cytokine involved inflammation cancer development gene consists eight small exons mrna nine alternative spliced isoforms thought secreted contains internal signal sequence lacks transmembrane region initially expressed selectively activated cells mitogen activated cells expression strongly augmented microbes mitogens cytokines induced mainly pathogens pro inflammatory cytokines prominent immune cells non immune tissues transcript expressed various human tissues organs spleen thymus leukocyte lung small intestine colon prostate heart placenta liver muscle kidney pancreas brain cytokines critical components cell signaling pathways involved regulation cell growth metabolism hormone signaling immune regulation variety physiological functions earlier studies demonstrated regulates cell growth metabolism immune regulation therefore involved pathologic regulator protectant inflammatory diseases previous studies defined upregulated patients several inflammatory diseases induced inflammatory responses however several reports suggested downregulated several inflammatory diseases including asthma hiv infection disease neuronal diseases metabolic disorders experimental colitis metabolic disorders also involved various cancer malignancies including renal cancer esophageal cancer hepatocellular carcinoma lung cancer gastric cancer breast cancer pancreatic cancer lymphoma osteosarcoma breast cancer colon cancer thyroid carcinoma studies suggested decreases tumor development including cervical cancer colon cancer prostate cancer melanoma pancreatic cancer liver cancer chronic myeloid leukemia nevertheless review articles discuss roles mechanism isoforms focusing therapeutic approaches yet reported review article discuss recent findings regarding development diseases discuss therapeutic approaches targeting moreover suggest could target several diseases therapeutic agents targeting may potential beneficial effects treatment inflammatory diseases cancers future research open new avenues design novel therapeutic approaches targeting elsevier inc rights reserved
setting march first multidrug resistant tuberculosis mdr treatment programme implemented kenya objective describe patients treatment outcomes adverse events design retrospective case note review patients started mdr treatment two medecins sans frontieres supported sites national referral hospital kenya undertaken sites operated ambulatory model care patients treated minimum months least drugs intensive phase treatment including injectable agent results patients human immunodeficiency virus hiv positive culture positive baseline adverse events occurred patients nausea vomiting electrolyte disturbance dyspepsia hypothyroidism median time culture conversion months treatment outcomes follows success deaths lost follow treatment failure hiv positive individuals adjusted odds ratio aor confidence interval women aor higher risk unfavourable outcomes risk lower culture conversion months aor conclusion kenya ambulatory model care used mdr treatment treatment success high despite high rates hiv almost half patients experienced electrolyte disturbance one third hypothyroidism supports view systematic regular biochemical monitoring needed kenya
increasing demand tools support land use planning processes particularly design zoning maps one complex tasks field task different land use categories need allocated according multiple criteria problem formalized terms multiobjective problem paper generalizes complements previous work topic presents algorithm based simulated annealing heuristic optimizes delimitation land use categories cadastral parcel map according suitability compactness criteria relative importance criteria adapted particular case despite high computational cost use plot polygons decided realistic terms technical application land use laws due computational costs proposal parallel implementations required several approaches shared memory systems multicores analysed paper results real case study conducted spanish municipality guitiriz show parallel algorithm based simulated annealing feasible method design alternative zoning maps comparisons results experts reported show high similarity results strategy outperform experts terms suitability compactness parallel version code produces good results terms speed crucial taking advantage architecture current multicore processors elsevier ltd rights reserved
clause united nations convention rights child states children right seek receive impart information ideas kinds regardless frontiers either orally writing print art media child voice however one area directive constrained various countries domestic regulations curtailing children access information area human sexuality arguments children access sex education well rehearsed article author pursues different angle looking instead increasing restrictions placed upon young people ability imagine communicate sexual issues particularly online settings advent internet range social networking sites enabled young people access previously quarantined information sexuality also actively engage forms intimate citizenship online article author focuses young people online fan communities use characters popular culture harry potter range japanese manga animation imagine explore sexual issues child abuse publications legislation australia elsewhere criminalizes representation even imaginary characters may appear age sexual scenarios hence children young people danger charged offence manufacturing disseminating child pornography despite research fandoms indicates positive benefit young people developing sexual literacies increasingly diminishing space young people age imagine communicate sexuality even context purely fictional scenarios
broad band solar thermal conversion materials highly desired solar energy harvesting purpose work demonstrate simple straightforward strategy engineer broad band solar thermal conversion nanofluids stable two component nanofluids containing copper oxide cuo antimony doped tin oxide ato nanoparticles prepared surface modification cuo nanoparticles reference cuo nanofluids strong absorption visible region near infrared region contrary ato nanofluids strong absorption near infrared region absorption visible region comparatively weak combination cuo ato nanoparticles endows two component nanofluids broad band absorption across visible near infrared region two component nanofluids vol show absorption spectrum match well solar spectrum give solar weighted absorption fraction compared cuo ato nanofluids respectively solar thermal utilization efficiency two component nanofluids determined compared cuo ato nanofluids respectively enhanced solar thermal conversion properties two component nanofluids attributed complementary optical absorption cuo ato nanoparticles work provides promising strategy engineer nanofluids solar energy harvesting
primary features alzheimer disease extracellular amyloid plaques consisting mainly deposits amyloid beta beta peptides intracellular neurofibrillary tangles nfts sets evidence suggest interleukin involved pathogenesis herein investigated protective role cells provide new insights understanding disease western blot employed assess protein levels bax phospho tau well phospho jak mtt assay performed decipher cell viability treatment decreased beta induced tau phosphorylation apoptosis effects blunted jak inhibition prevents beta evoked tau protein hyperphosphorylation apoptosis jak signaling
objective identify predictors delayed recovery children sustained concussion sought care pediatric hospital design retrospective cohort study design setting montreal children hospital concussion clinic database patients children sustained concussion sought care within days injury complete medical history postconcussion symptom scale pcss score available independent variables total symptom score pcss sex age history concussion sleep disturbances anxiety learning disabilities attention problems depression main outcome measure delayed recovery days results total children mean age years included total pcss score days postinjury identified significant predictor delayed recovery odds ratio conclusions study demonstrates potential clinicians identify sole use pcss children risk experiencing symptoms longer periods time
work presents application forward inverse predictive modeling methodology cacuci ionescu bujor inverse mode determine within tight priori specified convergence criterion overall accuracy unknown time dependent boundary condition specifically time dependent inlet acid concentration dissolver model case study using measurements state function specifically time dependent acid concentration specified location specifically dissolver compartment farthest inlet unknown time dependent boundary condition described unknown discrete scalar parameters forward inverse predictive modeling methodology uses maximum entropy principle construct optimal approximation unknown priori distribution using priori known mean values uncertainties characterizing model parameters along computed experimentally measured model responses covariances priori distribution subsequently combined using bayes theorem likelihood provided computational model first order response sensitivities serve weighting functions objective combination computational experimental information use maximum entropy principle enables forward inverse predictive modeling cacuci ionescu bujor construct intrinsic regularizing metric solving inverse problem present dissolver case study unknown time dependent boundary condition predicted methodology within priori selected convergence criterion without user intervention introduction arbitrary regularization parameters currently popular procedures need predictive modeling methodology yields optimally calibrated values model parameters reduced predicted uncertainties well optimal best estimate predicted values model responses case study time dependent acid concentrations dissolver compartments also reduced predicted uncertainties notably even though experimental data pertain solely compartment farthest inlet data measured application predictive modeling methodology actually improves predicted values reduces predicted uncertainties compartment data actually measured also throughout entire dissolver including compartment farthest measurements inlet forward inverse predictive modeling methodology combines transmits information simultaneously entire phase space comprising time steps spatial locations results underscore importance work presenting objective resolution resolution absence user defined subjective adjustment arbitrary regularization parameters time dependent inverse case study potential importance diversion activities associated proliferation international safeguards results obtained work establish confidence dissolver model accuracy simulating acid concentrations required dissolve used nuclear fuel turn results used generate source terms key reprocessing facility components downstream support material accountability nuclear safeguards
global skyline important variant skyline widely applied multi criteria decision making business planning data mining paper extend early work propose maintenance methods process subspace global skyline sgs queries dynamic databases previous work proposed index structure tree effectively manage data accelerate subspace global skyline calculation also basic single sgs algorithm based tree ssrb optimized single sgs algorithm ossrb proposed process single sgs query addition multiple sgs algorithm msrb proposed calculate multiple sgs queries sharing scan spaces different queries paper design data structures propose maintenance approaches ssrb ossrb msrb cope updates happen data sets thus extended algorithms adopted dynamic data sets finally experimental results show proposed algorithms ossrb msrb good performance process sgs queries easily maintained dynamic datasets
adam disintegrin metalloproteinase domain containing protein alpha secretase involved app beta amyloid precursor protein processing enhancement nonamyloidogenic app pathway adam provides therapeutic potential alzheimer disease using high throughput screening targeted adam determined apicidin inhibitor hdacs histone deacetylases significantly increased mrna protein levels adam syy cells luciferase assay revealed nucleotides adam promoter sufficient mediate effect addition knockdown usf upstream transcription factor hdac prevented apicidin regulation adam moreover usf acetylation increased apicidin enhanced association usf hdac adam promoter found apicidin affect phosphorylation erk usf however erk inhibitor blocked effect apicidin adam finally apicidin increased level site terminal fragment app reduced production amyloid peptide collectively study provides evidence adam expression regulated hdac inhibitor apicidin via usf dependent mechanisms erk signaling plays important role thus hdac regulation adam might shed new light understanding pathology zhu zhao wang liu lai deng chen histone deacetylase inhibitor apicidin increases expression secretase adam transcription factor usf mediated mechanisms faseb www fasebj org
background paper studies impact musical religious songs hymns managing stress indian engineering students galvanic skin response gsr objective objective paper find whether listening hymns able reduce value gsr methods sample students selected initial screening students reported high mental stress interview selected main drills readings taken using gsr meter statistical test used purpose hypothesis testing results study examines relation gsr stress results indicated listening hymns significant effect value gsr results highlight gsr decreased seconds experimental group listened hymns compared control group exposed conclusion recommended amazingly effortless yet highly efficient traditional technique listening hymns made part student routine curriculum paper aims spreading awareness listening hymns one modes stress management amongst indian engineering students
due lack ditch maintenance many ditches upper reaches yangtze river strongly affected nutrient enrichment accordingly conducted surveys nutrient concentrations ditchwater sediment hilly area central sichuan basin investigate spatiotemporal variations nutrient concentrations promote restoration ditches ecological functions results showed mean total nitrogen particulate nitrogen nitrate nitrogen ammonia nitrogen total phosphorus values ditchwater respectively mean concentrations total nitrogen nitrate nitrogen ammonia nitrogen total phosphorus ditch sediment respectively higher total nitrogen concentrations ditchwater occurred western areas higher total phosphorus concentrations occurred central areas seasonally measured higher nitrogen phosphorus concentrations ditchwater close agricultural areas rainy season opposite effect true residential areas although nutrient concentrations ditchwater could affected surrounding land uses ditch water levels land use critical moreover nitrogen phosphorus concentrations significantly higher ditchwater near residential areas compared paddy sloping cropland ditches however found significant differences nutrient contents sediments ditches surrounded different land uses results indicate water pollution control initiatives residential areas would critical factor combating ditchwater sediment pollution region therefore efforts restore ecological functions drainage ditches take account rural township sewage management fertilizer reduction especially ditch vegetation restoration
transition casual compulsive drug use thought occur consequence repeated drug taking leading neuroadaptive changes brain circuitry involved emotion cognition basis neuroadaptations lie changes expression immediate early genes iegs implicated transcriptional regulation synaptic plasticity intracellular signalling however little known ieg expression patterns change long term drug self administration present study therefore compares effects day self administration cocaine sucrose expression iegs brain regions implicated addictive behaviour dorsal striatum ventral striatum medial prefrontal cortex mpfc increased expression cocaine self administration found iegs dorsal ventral striatum fos mkp fosb delta fosb egr egr arc iegs mpfc iegs striatum plus bdnf homer sgk rgs five iegs egr fosb delta fosb bdnf homer jun trkb mpfc responsive long term sucrose self administration importantly major differences found ieg expression patterns days cocaine self administration except fosb delta fosb dorsal striatum egr mpfc whereas amount cocaine obtained per session comparable short term long term self administration steady changes ieg expression therefore associated stable self administration behaviour rather total amount cocaine consumed thus sustained impulses ieg regulation prolonged cocaine self administration may evoke neuroplastic changes underlying compulsive drug use
introduce heuristic called pseudocontingencies pcs alternative account various stereotyping phenomena pcs give rise expectation attributes correlated based solely asymmetries attribute base rates attributes encountered frequently attributes encountered rarely perceived correlated differences information densities typical many stereotyped targets including self others group groups majority minority groups evidence reviewed pcs underlying illusory correlations confirmation biases gender stereotypes simpson paradox procedures used implicit stereotype measurement pcs shown predict specific patterns self enhancement self depreciation effects intergroup contact group biases readiness infer stereotypes aggregated big data although pcs lead seriously flawed stereotypic expectations afford efficient possibly adaptive inference strategy
traditional approach extracting important features application analyze anomaly detection problem introduce significant overhead way switch handling furthermore high volumes network traffic introduce notable issues affect performance anomaly detection accuracy taking advantage centralized control plane software defined networking sdn task handle flow information much simplified programmatically accuracy measured flow statistic plays important role anomaly detection use sampling capable lessen scalability problem traffic monitoring insufficiency sampled flow statistic may led inaccurate detection rate anomaly paper propose adaptive sampling strategy able provide essential traffic statistics accurate anomaly detection sdn sampling mechanism utilizes clustering analysis used classify attack network determine severity monitored traffic manipulating type service incoming packet together two important parameter formulate sampling mechanism algorithm show experimentally putting higher polling frequency detected anomalous flow able detect network attacks much accurate
mobile applications becoming popular prevalence mobile operating systems mobile internet many consume services provided underlying infrastructure platforms part application environmental contexts however application failures downgrade performance may results due inadequate provisions environmental issues implementations mobile applications paper propose framework enable mobile applications consume services offered reliable context provider high probability run time report case study suite five real world mobile applications real faults real mobile phones involving users results case study show framework significantly improve reliability mobile applications respect failures due buggy contextprovider faults low slowdown energy overheads
infrahumanization research verified intergroup contexts strong tendency attribute secondary emotions uniquely human ingroup limiting attribution outgroups experiments shown common ingroup bias however yet known characteristics may mitigate trend paper presents two studies first analyzes impact helping behavior attributions human traits two fictitious groups second study objective determine members spanish ingroup would infrahumanize ethiopian outgroup less outgroup performs prosocial behavior towards another group infrahumanization determined lexical decision task using names ingroup outgroup members priming results demonstrate describing fictitious group altruistic terms increases human profile experiment one reduces infrahumanization experiment two
paper develops concept large size flash memory based pulsewidth modulated pwm algorithms three phase inverters algorithms differ conventional counter based implementation follow preprogrammed optimal pwm pattern read large size memory magnitude phase coordinates sequence states thus possible within pwm sampling interval novel digital structure built around newly released flash memory integrated circuits paper demonstrates feasibility operation pwm sampling frequency khz using gigabit size flash memory integrated circuits along low cost microcontroller spi peripheral empower concept multioptimal pwm proposed implemented gbit memory table harmonics phase currents reduced constant pwm sampling frequency maintained order comply conventional vector control methods grid motor applications
study long span suspension bridge wind vibration data collected long term monitoring system year used cluster analysis automatic fast clustering algorithm employed recognize vortex induced vibrations vivs bridge deck long term monitoring datasets acceleration amplitude root mean square frequency ratio selected indicators clustering vivs vibrations cluster analysis conducted wind speed field viv samples arid results indicate nonuniformity wind speed along span wise direction significant influence viv mode relationship wind speed field viv mode obtained clustering consideration nonuniformity wind speed elsevier ltd rights reserved
objective since reconstruction composite defects head neck region challenging demanding problem head neck surgeons surgical aids sought decades purpose study evaluate accuracy prefabricated surgical resection templates used mandibular segmental resections comparison virtual surgical plan materials methods prospective study performed consecutive patients primary oral squamous cell carcinoma osteoradionecrosis mandible preoperatively cbct scan acquired delineate size extension tumor invasion virtual patient specific resection template designed based information intraoperatively resection template positioned mandible secured using four fixation screws postoperatively cbct scan acquired scan superimposed preoperative scan positioning resection template inclination resection planes evaluated virtual head model order test interobserver reliability new measurement methods two different observers executed measurements results mean shift proximal resection templates standard deviation distal resection templates mean shift significant interobserver difference icc absolute mean deviation degrees degrees found proximal resection angle degrees degrees distal resection angle significant interobserver differences found icc conclusion resection templates used study proved reasonably accurate although concept virtual surgical planning aids significantly mandibular reconstruction microvascular free flaps improvement resection accuracy necessary improvement reconstruction accuracy published elsevier ltd behalf european association cranio maxillo facial surgery
aim advance business management construction via independent literature review construction related concepts published focal firms based oecd countries concepts related construction management concepts industrial management international marketing concepts project management concepts corporate real estate combined share porterian dynamism based organisation based knowledge based concepts concept platform neither highly theoretically advanced highly applicable propositions defined advancement authors published elsevier
histoplasmosis blastomycosis two common midwestern endemic mycoses history exposure geographic areas organisms occur central raising suspicion endemic fungal infection infection organisms diagnosis definitively established recovery organism tissue body fluids may take weeks rapid diagnosis made finding distinctive yeasts tissues body fluids antigen testing allows presumptive diagnosis endemic fungal infections awaiting culture results cross reactivity assays histoplasma blastomyces routinely seen antibody tests provide supportive evidence infection either endemic mycoses less useful immunosuppressed patients
exist two key problems data aggregation thoroughly explored algorithm design networking layer algorithm design application layer two problems subtlety tackled termers high efficiency robustness therefore former one requires survivability highly reliable design networking layer latter one usually asks high efficiency robustness application layer moreover optimization algorithms also considered enhancement integrity check key requirement optimization context aware cross layer design applied optimization dynamic fragment odd even parity checking code proposed context aware aggregative integrity check code proposed
health research increasingly aging population calls careful consideration aging associated phenomena dementia accounting diseases necessary step gaining view health elderly moreover imperative gather data subjects mental limitations surveys better evaluate validity answers disclosed elderly participants article discusses availability data individuals suffering dementia national studies aging centers question surveys respond challenge diagnosing dementia analysis based literature review focuses national studies aging conducted later enforced upper age limit least years old subjects evaluating published studies analyzing data descriptively determined many subjects suffering dementia part sample methods applied diagnose illnesses overall availability data age aging satisfactory germany literature review discovered seven studies aging well five lend framework oriented toward research aging number subjects suffering dementia samples half studies reach less affected results thus point problems surveying individuals suffering dementia highlight limitations studies aging account dementia subjects following discussion aims contribute debate relevant research methodology development methodological approaches consider dementia crucial factor
rationale relaxin hormone considered potential therapy patients fibrotic diseases objectives gauge potential efficacy relaxin based therapies idiopathic pulmonary fibrosis ipf studied gene expression relaxin insulin like family peptide receptor rxfp ipf lungs controls methods analyzed gene expression data obtained lung tissue research consortium correlated rxfp gene expression data cross sectional clinical demographic data also employed vivo donor ipf lung fibroblasts test rxfp expression vitro tested cgen relaxin like peptide lung fibroblasts bleomycin injury measurements main results found rxfp significantly decreased ipf patients ipf magnitude rxfp gene expression correlated directly diffusing capacity lung carbon monoxide significantly less rxfp detected vitro ipf fibroblasts donor controls transforming growth factor beta decreased rxfp donor ipf lung fibroblasts cgen effective decreasing bleomycin induced acid soluble collagen deposition vivo relaxin like actions cgen abrogated rxfp silencing vitro comparison donor lung fibroblasts ipf lung fibroblasts exhibited decreased sensitivity relaxin like effects cgen conclusions ipf characterized loss rxfp expression rxfp expression directly associated pulmonary function patients ipf relaxin like effects cgen vitro dependent expression rxfp data suggest patients ipf highest rxfp expression would predicted sensitive relaxin based therapies
paper describes necessity integrated computerization manufacturing engineering process aims requirements modem integrated systems also presents integrated computer aided manufacturing engineering system sat structure main functions data base area application
biomass bioproducts bioenergy sourced multiple sources little information commercial planting operations willow biomass crops north america objectives study evaluate field capacities two commercial machines step egedal energy planter planting willow crops northern new york state determine amount distribution delays study conducted evaluate planter activities two machines similar mean field capacities ranging average rainfall later part planting season decreased step planter largely due delays headlands approximately total delay time associated step planter consisted long duration delays min compared egedal quality planting stock issue operations undersized stems resulted feeding issues several potential factors identified improved planting operations loading stems clearing feeding mechanisms turn improved planting stock quality control improving machine design wet conditions improved preparation field repairs field delays minimized reduce demand crew ensure uniform crop established field elsevier ltd rights reserved
entropic lattice boltzmann methods introduced overcome stability issues lattice boltzmann models high reynolds number turbulent flows however date validity investigated simple flows due lack appropriate boundary conditions present extension models complex flows involving curved moving boundaries three dimensions apart thorough investigation resolved resolved simulations periodic flow turbulent flow round pipe study detail set simplified internal combustion engine valve piston arrangement arrangement allows probe non trivial interactions various flow features jet breakup jet wall interaction formation breakup large vortical structures among others besides order magnitude reduction computational costs compared state art direct numerical simulations dns methods come additional advantage using static cartesian meshes also moving objects reduces complexity scheme going beyond first order statistics detailed comparison mean root mean square velocity profiles high order spectral element dns simulations experimental data shows excellent agreement highlighting accuracy reliability method resolved simulations moreover show implicit subgrid features entropic lattice boltzmann method utilized reduce grid sizes computational costs providing alternative modern modelling approaches large eddy simulations complex flows
background microrna mir reported downregulated parkinson disease regulatory mechanism mir neuron apoptosis autophagy still poorly understood aimed investigate neuroprotective effects mir vitro material methods human neuroblastoma cells incubated different concentrations methyl phenylpyridinium ion mpp induce model expression mir analyzed transfection mir mimic scramble following mpp treatment expression autophagy protein markers lcii lci beclin mitogen activated protein kinase mapk jun terminal kinases jnk signaling proteins jnk jnk cell apoptosis detected furthermore cells transfected mir inhibitor cultured presence absence inhibitor jnk inhibitor cell apoptosis tested results expression mir gradually decreased increase mpp concentration overexpression mir significantly decreased lcii lci ratio beclin expression cell apoptosis expression jnk compared mpp mir scramble group addition observed showed effects cell apoptosis effects mir inhibitor cell apoptosis reversed administration compared scramble group conclusions results suggest mir regulates apoptosis autophagy inhibiting mapk jnk pathway
since decades sensors computer programming became part automation industry number sensors programming languages evolving ancient technologies repairable kept aside indeed use electricity major source makes system work available electricity makes system costlier applications connection availability electricity present research work evolve automatic flusher work mechanical linkage eliminating use sensors programs finally electricity present investigation economical operable conditions throughout year without external driving power
paper presents novel method design analog integrated circuit making use fixator norator pairs performance design biasing design fixators distinctive tools setting critical design parameter desired value whereas pairing norator renders critical parameters adequate supporting components mainly resistors analog ics active loads current mirrors serve supporting components hence use fixator norator pairs may abbreviate defining dynamic static resistance active loads current mirrors affirmative given design proposed methodology illustrated use common emitter amplifier bjt differential amplifier mos operational amplifier three stage cmos operational amplifier
nasu hakola disease nhd rare disease characterized bone cysts fractures frontal lobe syndrome progressive presenile dementia nhd may prototype primary microglial disorders cns coined microgliopathies mutations trem tyrobp genes known cause nhd interestingly recent evidence associated rare genetic variants trem gene increased risk alzheimer disease frontotemporal dementia amyotrophic lateral sclerosis parkinson disease report year old greek female phenotype suggestive nhd full gene sequencing trem tyrobp genes revealed novel mutation exon trem gene namely heterozygosity parents brother report extends range trem mutations cause nhd phenotype addition provide comprehensive review reported literature trem gene mutations respective wide spectrum clinical manifestations highlights importance considering trem gene mutations variety neurodegenerative phenotypes elsevier inc rights reserved
cryptococcosis fungal infection caused cryptococcus neoformans tends affect immunocompromised individuals fungi mostly acquired inhalation leads initial pulmonary infection later organs central nervous system skin affected hematogenous spread addition cutaneous contamination occur primary inoculation injuries primary cutaneous cryptococcosis whose diagnosis defined based absence systemic involvement clinical presentation cutaneous forms typically vary according infection mode report unusual case disseminated cryptococcosis immunocompetent patient cutaneous lesions similar caused primary inoculation clinical picture leads question definition primary cutaneous cryptococcosis established literature
background australian government approval use mifepristone misoprostol medical termination pregnancy mtop allows general practitioners gps provide early gestation abortion primary care settings however uptake mtop provision gps appears low reasons unclear study investigated provision referral mtop gps methods undertook descriptive interpretive qualitative research selected participants diversity using matrix twenty eight semi structured interviews one focus group conducted gps mtop providers non mtop providers new south wales australia interviews recorded transcribed verbatim framework examine access abortion services used develop interview questions emergent themes identified thematically results three main themes emerged scope practice mtop demand care referral workforce needs many gps saw abortion beyond scope practice service others provide specialist private clinics gps religious moral objections others regarded mtop provision complicated difficult gps expressed interest mtop provision concerned stigma impact may perceptions practice views colleagues despite reported variance demand mtop providers busy felt isolated difficulties referral local public hospital case complications provision surgical abortion noted conclusions exploring factors affect access mtop general practice settings provides insights assist future planning delivery reproductive health services research identifies need support increase number mtop providers gps currently providing mtop alongside actions provision public sector required addition formalised referral pathways public sector required ensure timely care case complications provision surgical options leadership coordination across health sector needed facilitate integrated abortion care particularly rural low income women
large scale deployment renewable energy sources res plays central role reducing emissions energy supply systems intermittency solar wind technologies presents integration challenges high temperature electrolysis steam power gas ptg power liquid ptl configurations could utilize excess intermittent electricity converting chemical fuels directly consumed sectors transportation heating used power storage investigate impact carbon policy fossil fuel prices economic engineering potential ptg ptl systems storage intermittent renewable electricity source low carbon heating transportation energy alpine region employ spatially temporally explicit optimization approach res ptg ptl fossil technologies electricity heating transportation sectors using bewhere model results indicate large scale deployment ptg ptl technologies producing chemical fuels excess intermittent electricity feasible particularly incentivized carbon prices depending carbon fossil fuel price million tonnes year captured used synthesis chemical fuels displacing current fossil fuel use transportation providing physical link electricity transportation heating sectors ptg ptl technologies enable greater integration res energy supply chain globally elsevier ltd rights reserved
idiopathic pulmonary fibrosis common interstitial lung disease derived chronic inflammatory insults characterized massive scar tissue deposition causes progressive loss lung function subsequent death respiratory failure bleomycin used standard agent induce experimental pulmonary fibrosis animal models study pathogenesis however visualize establishment lung fibrosis treatment animal sacrifice necessary thus aim study avoid limitation using innovative approach based double bleomycin treatment protocol along vivo images analysis bleomycintreated mice reporter gene construct containing luciferase open reading frame matrix metalloproteinase promoter control region tested double bleomycin treated mice investigate real time correlation bleomycin treatment inflammation tissue remodeling fibrosis bioluminescence emitted lungs bleomycin treated mice corroborated fluorescent molecular tomography successfully allowed real time monitoring fibrosis establishment reporter gene technology experienced work could represent advanced functional approach real time non invasive assessment disease evolution therapy reliable translational living animal model
background need challenge messages reinforce harmful negative discourses around sexual risk responsibility priority improving sexual health mass media important source information regularly alerting updating influencing public opinions way sexual health issues framed may play crucial role shaping expectations responsible sexual health risks healthy sexual practices methods conducted depth qualitative analysis negatively toned newspaper articles reporting sexual health topics examine risk responsibility framed within relation gender articles published seven three scottish national newspapers included latent content analysis approach taken focusing interpreting underlying meaning text results key theme articles men framed risk women sexual health whilst part women role resist men advances discourses tended portray power imbalance sexual relationships women men number articles argued women needed take responsibility sexual health articles repeatedly suggested women teenage girls particular lacked skills confidence negotiate safer sex sex education programmes often presented failed men frequently portrayed promiscuous engaging risky sexual health behaviours women yet one article drew attention lack focus male responsibility sexual health gay men used bench mark rates measured framed risk risk conclusions framing men risk women whilst women presented time responsible patrolling sexual encounters organising contraception preventing sexual ill health reinforces gender stereotypes undermines efforts promote collective responsibility sexual health implications sexual ill health prevention could continue reinforce negative culture around sex relationships sexual health
paper presents functional safety problems technical systems aims verify safety integrity level selected integrated safety system paper provides comparative analysis safety integrity level application monte carlo simulation reliability block diagram rbd methods additionally solution proposed section logical structure called voting zones significantly reduce risk causing false alarms calculations preceded review existing studies functional safety extensive technical systems verification done following requirements iec commonly accepted standard field functional safety programmable electronic control engineering systems elsevier ltd rights reserved
aim project demonstrate protections interlocks available critical equipments power station boiler turbine alternator critical equipments protected abnormal conditions parameters failure one equipments lead loss power generation cost equipments huge boiler got protection abnormal drum level abnormal live steam pressure abnormal live steam temperature abnormal furnace pressure turbine got protection abnormal condenser vacuum abnormal lubricating oil pressure abnormal axial shiftand abnormal turbine speed similarly generator also got following protections earth fault earth fault differential protection incomplete phase condition rotor earth fault stator inter turn fault current protection stator overvoltage rotor overvoltage protections classified class class class protections distributed digital controls numerical protections relays play vital role providing protections critical equipments demonstrate protections real sense project kit however effort made demonstrate functioning protections aid programmable logic controller also suggestions improve existing system also discussed
research exploring perspectives stigmatized people examined general processes related experiencing prejudice past work however invoked assumption prejudices different group memberships experienced similar manner across three studies directly compare experiences racism sexism among female minorities show contrast people respond different forms prejudice distinct ways study examined attributions invoked asian women explain prejudice discovered participants made stronger internal attributions explain racism sexism study investigated emotional reactions prejudice found asian women report experiencing depression following race based rejection gender based rejection study observed asian women reported perceiving racism sexism environments implications advancing theories prejudice experiences discussed
humans biological predisposition form attachment social partners attachment however restricted humans non human inanimate targets often involved people increasingly engaged mobiles whether behaviour toward devices regarded attachment behaviour yet experimentally tested hypothesized existence mobile attachment expected people seek proximity mobile give stress response upon separation manifests behavioural physiological level also predicted separation mobile induce specific separation related emotions leads increased attention separation related stimuli applied version strange situation test using mobile phone behavioural physiological cognitive self report measures emotional stroop test additionally constructed questionnaire self assess mobile attachment separation mobile induced behavioural physiological stress proximity seeking behaviour attentional bias separation related stimuli participants higher mobile attachment effects observable mobile present according questionnaire secure base safe also relevant aspects attachment mobile results support humans form attachment toward mobile similar social attachment could emerge cultural recycling attachment system evolutionary structures elsevier ltd rights reserved
paper contains extensive review life cycle assessment lca studies greenhouse gas emissions ghg different material based photovoltaic working mechanism based concentrating solar power csp electricity generation systems statistical evaluation life cycle ghg emissions conducted assess role different pvs csps reducing ghg emissions widely used parabolic trough central receiver csp electricity generation systems emitted approximately ghgs paraboloidal dish solar chimney solar pond csp electricity generation systems cadmium telluride pvs solar pond csps contributed minimum life cycle ghgs thin film pvs also suitable wider implementation due lower energy pay back time epbt periods addition lower ghg emission comparison pvs
paper propose software architecture allows processing large geospatial data sets cloud system modular flexible supports multiple algorithm design paradigms mapreduce memory computing agent based programming contains web based user interface domain experts gis analysts urban planners define high level processing workflows using domain specific language dsl workflows passed number components including parser interpreter service called job manager components use declarative procedural knowledge encoded rules generate processing chain specifying execution workflows given cloud infrastructure according constraints defined user job manager evaluates chain spawns processing services cloud monitors services communicate distributed file system scalable fault tolerant compared previous work describing cloud infrastructures architectures focus processing big heterogeneous geospatial data addition rely one specific programming model certain cloud infrastructure support several ones combined possibility control processing dsl based workflows makes architecture flexible configurable see cloud means store distribute large data sets also way harness processing power distributed computing environments large volume geospatial data sets proposed architecture design developed iqmulus research project funded european commission paper concludes evaluation results applying solution two example workflows project elsevier ltd rights reserved
flux switching machine large air gap toroidal winding design presented fractional slot winding core flux switching machine wound around stator yoke instead stator pole machine design basis core flux switching machine several modifications stator core shape arrangement evaluated means finite element analysis significant enhancement torque capability toroidal winding design achieved minor changes stator core shape additionally application halbach shaped magnets leads even torque reduction leakage flux stator outer diameter
study discusses biosorption ion aqueous solution using ultrasonic assisted spirulina platensis uasp prepared uasp biosorbent characterised fourier transform infrared spectroscopy ray diffraction brunauer emmet teller scanning electron spectroscopy energy dispersive ray thermogravimetric analyses optimum condition maximum removal ions initial concentration uasp measured adsorbent dose contact time min temperature adsorption isotherm kinetics thermodynamic parameters calculated freundlich model provided best results removal ions uasp adsorption kinetics ions onto uasp showed pseudo first order model well line experimental data thermodynamic study parameters like gibb free energy enthalpy entropy changes evaluated result explains adsorption ions onto uasp exothermic spontaneous nature desorption biosorbent done using different desorbing agents naoh gave best result prepared material showed higher affinity removal ions may alternative material existing commercial adsorbents
use quantitative analysis children limited lack normal values lung parenchymal attenuation characteristics important normal lung development yields significant parenchymal attenuation changes children age perform quantitative characterization normal pediatric lung parenchymal ray attenuation routine clinical conditions order establish baseline comparison seen pathological lung conditions conducted retrospective query normal chest examinations children ages years using standard clinical protocol examinations semi automated lung parenchymal segmentation performed measure lung volume mean lung attenuation analyzed examinations children ages days months mean standard deviation months lung volume ranged liters mean lung attenuation much higher children younger months values high hounsfield units neonates lung volume lung volume decreased approximately age years lung volume subsequently slower exponential decrease toward relatively constant value age lung volume increased normal lung parenchymal ray attenuation decreases increasing lung volume age lung attenuation decreases rapidly first years age slowly thereafter change normal lung attenuation taken account quantitative methods translated pediatric pulmonary imaging
background elbow second commonly dislocated major joint general population previous studies focused emergency department populations indicate injuries occur frequently among adolescent athletes purpose describe epidemiological rates patterns sports related elbow dislocations high school athletes study design descriptive epidemiology study methods sports related injury data academic years national convenience sample high schools participating national high school sports related injury surveillance study high school reporting information online rio analyzed results certified athletic trainers participating high school rio reported elbow injuries elbow dislocations total athlete exposures aes reported study period resulting dislocation rate per aes majority dislocations resulted boys wrestling football elbow dislocation rates higher competition practice also dislocations occurred boys sports among boys girls majority injuries occurred varsity sports activities contact another person common injury mechanism followed contact playing surface dislocations commonly resulted removal play weeks respectively medical disqualification respectively compared elbow injuries dislocations also likely result surgical treatment elbow injuries respectively conclusion high school athletes elbow dislocations result longer removal play likely require surgical treatment nondislocation associated elbow injuries rates patterns elbow dislocations vary sport high risk sports focused sport specific prevention strategies may help decrease rates severity elbow dislocation injuries
enrichment specific pollutant reducing consortium usually required prior startup bio cathode bioelectrochemical system bes whole process time consuming rapidly establish non specific functional biocathode direct polar inversion bioanode biocathode proposed study based diverse reductases electron transfer related proteins anode respiring bacteria arb acclimated electrochemically active biofilm eab may catalyze reduction different aromatic pollutants within approximately acclimated bioanodes directly employed biocathodes nitroaromatic nitrobenzene azo dye acid orange reduction results indicated established biocathode significantly accelerated reduction aniline discolored products compared abiotic cathode open circuit controls several microbes possessing capabilities nitroaromatic azo dye reduction bidirectional electron transfer maintained enriched biocathode communities cyclic voltammetry highlighted decreased potentials enhanced electron transfer biocathode well demonstrated arb geobacter containing cytochrome involved backward electron transfer electrode study offers new insights rapid establishment modularization functional biocathodes potential treatment complicated electron acceptors coexisting wastewaters elsevier rights reserved
purpose study present computational method applicable stability analyses structures paper typical complex eigenproblem monodromy matrix solved order perform stability analysis vehicle streams moving along bridge inertia forces vehicles springing vehicles taken account unstable structure vibrations detected instability combination parametric resonance one combination parametric resonance typical one involves interaction two three numerous modal forms simultaneously authors published elsevier ltd
background purpose study evaluate programme lesion surgery carried patients treatment resistant depression trd method retrospective study looking clinical psychometric data patients trd undergone bilateral stereotactic anterior capsulotomy surgery period years approval mental health act commission unipolar depression eight bipolar disorder beck depression inventory bdi surgery used primary outcome measure montgomery asberg depression rating scale administered cognitive aspects executive memory functions also examined carried paired samples test outcome measures determine statistically significant change group consequence surgery results patients improved clinical measure depression surgery points bdi change significant cognitive changes post surgery six patients followed phone interview reported generally positive experience major surgical complications occurred conclusions limitations uncontrolled observational study data suggest capsulotomy effective treatment otherwise trd performance neuropsychological tests deteriorate
recent advent induced pluripotent stem cells enabled study patient specific disease related neurons vitro facilitated new directions inquiry disease mechanisms approaches possibility correlating vivo cellular phenotypes individual patient response treatment side effects makes targeted treatments schizophrenia bipolar disorder distinct prospect coming years briefly review current state stem cell based models explore studies providing new insights disease biology schizophrenia bipolar disorder laying foundations development novel targeted therapies
report theoretical experimental investigations hydride formation depending temperature recycling scraps structural investigations based scanning electron microscope ray diffraction xrd showed amount hydrogen incorporated matrix varied hydridation temperature xrd measurement showed mole ratio hydride increased increasing hydridation temperature degrees decreased increasing temperature furthermore depending hydridation temperature various phase hydride tah tah formed hydride process verified thermodynamic analysis elsevier ltd rights reserved
purpose review ensuring quality safety anaesthesia face budgetary restrictions changing demographics challenging france environment regulated legislation often necessary find solutions seize opportunities break traditional organization recent findings postoperative mortality remains excessively high move towards ambulatory care adequately integrated stages patient management context single therapeutic plan mutually agreed upon caregivers french national health authority provides certification healthcare establishments encourages seamless approach private practice hospital setting based teamwork interdisciplinary consultation daring break traditional organizational structures taking account human factors staged strategies possible deliver appropriate care level quality safety meets users demands summary management patient undergoing surgery anaesthesia seamless spectrum patient home hospital back home decision making must multidisciplinary increased use ambulatory care breaks traditional organizational structures efforts reduce postoperative mortality represents opportunities improve overall system performance demographic economic constraints potential threats identified
kuhn noted scientific fields processes paradigm change painful periods old theories longer fit available data placed new theories periods typically create strife debate ideological differences emerged proponents old new theoretical approaches current paper argue period reached within field aggression research past half century social cognitive social learning paradigms aggression exemplified general aggression model gam retained dominance particularly areas media violence contend data support gam social cognitive approaches aggression never conclusive newer evidence increasingly suggests gam social cognitive theories aggression generally adequate explain aggressive phenomena discuss weaknesses problematic sometimes hidden assumptions gam reduce utility paradigm current evidence suggests gam social cognitive paradigm aggression retired approaches focus diathesis stress hold greater promise elsevier ltd rights reserved
profile based features mechanical computer aided design cad system commonly complicated shapes guide curve free form type however considering interoperability heterogeneous cad systems kind free form guide curve makes difficult represent corresponding feature shape cad systems example ship cad systems usually use relatively simple shape primitives represent objects thus propose straightforward algorithm represent profile based features based guide curve approximation using line arcs segments addition solid alignment filling operations also provided complete entire process solid model reconstruction furthermore apply technique data exchange mechanical cad system ship cad system lastly use several test cases demonstrate effectiveness proposed method
governance silos settings different organizations work isolation avoid sharing information strategies siloes fundamental challenge environmental planning problem solving generally requires collaboration siloes overcome creating governance networks studying structure function networks important understanding create institutional arrangements respond biophysical dynamics specific natural resource system social ecological institutional fit using case salmon restoration sub basin puget sound usa assess network integration considering three different reasons network collaborations mandated funded shared interest relationships analyze different collaboration types relate productivity based practitioner assessments also illustrate specific targeted network interventions might enhance network use mixed methods approach combines quantitative social network analysis sna qualitative interview analysis overall sub basin governance network fairly well integrated several concerning gaps exist funded mandated shared interest relationships lead different network patterns mandated relationships associated lower productivity shared interest relationships highlighting benefit genuine collaboration collaborative watershed governance lastly quantitative qualitative data comparisons strengthen recent calls incorporate geographic space role individual actors versus organizational culture natural resource governance research using sna elsevier ltd rights reserved
objective aim study assess long term health related quality life hrql patients thoracoscopic open esophagectomy summary background data trials comparing minimally invasive open transthoracic esophagectomy shown improved short term outcomes however long term hrql data lacking prospective non randomized study compared hrql survival thoracoscopically assisted mckeown esophagectomy tamk open transthoracic ivor lewis esophagectomy ttil esophageal gastroesophageal junction gej cancer methods patients esophageal gej cancer selected tamk ttil completed baseline follow hrql assessments months using eortc generic disease specific measures qlq qlq oes baseline clinical variables examined treatment groups changes mean hrql scores time estimated tested using generalised estimating equations propensity score generated boosted regression adjustment results patients underwent tamk underwent ttil clinical variables similar groups however significantly patients ajcc stage disease underwent ttil tamk reflected survival data mean symptom scores pain significantly higher ttil group tamk years postoperatively addition mean constipation scores significantly higher ttil group point difference mean score months postoperatively conclusions large comprehensive nonrandomized analysis longitudinal hrql shows ttil associated pain constipation tamk
article analyses differences voting behaviour selectorate electorate italian partito democratico particularly focussing role played leadership ideology media affecting voting decisions study different motivations underlying decision vote italian general election one three candidates party leadership leadership selection race empirical analysis uses italian national election study candidate leader selection data results analysis show leadership evaluation stronger influence selectorate electorate perceived distance voters party left right continuum stronger impact electorate selectorate moreover analysis underlines media substantially relevant factor explaining voting behaviour electorate selectorate findings confirm relevancy leadership evaluation intra party competitions open new perspective study leader selection races
control lcl type three phase grid connected converter difficult due high resonance peak lcl filter active damping state art solution problem damping performance affected inherent time delay digital control especially high power low switching frequency applications based discrete time stability analysis lcl type converter capacitor current feedback active damping simple effective time delay compensation method based area equalization concept proposed method reduce negative impact computation delay significantly potential serve general solution time delay compensation digitally controlled pwm converter validity proposed method proved experimental results
canine dirofilarioses mosquito borne zoonotic diseases continuous expansion geographical distribution consequence different climatic ecological factors dirofilaria immitis aetiological agent heartworm disease gained major veterinary interest mainly due severe clinical implication last decades repens despite regarded less pathogenic species regained attention due recognized zoonotic potential romania traditionally regarded non endemic country recent epidemiological surveys highlighting presence repens immitis present case report describes clinical pathological features natural infection repens immitis year old male boxer north western romania based clinical laboratory investigations diagnosis kidney failure chronical cystitis established parasites identified morphology confirmed pcr sequencing best knowledge first worldwide report ectopic presence repens adults pelvic cavity mesentery natural infection first report ocular localization parasite romania clinical paraclinical findings suggest implication repens microfilariae aetiology histopathological lesions investigations needed order establish actual pathogenic potential repens frequently neglected parasite elsevier rights reserved
silent data corruptions sdcs errors corrupt system falsify results remaining unnoticed firmware operating systems numerical integration solvers sdcs impact accuracy solver considered significant detecting sdcs high performance computing necessary results need trustworthy increase number complexity components emerging large scale architectures makes sdcs likely occur recently sdc detection methods consisted replicating processes execution using checksums example algorithm based fault tolerance recently new detection methods proposed relying mathematical properties numerical kernels performing data analysis results modified application none methods however provide lightweight solution guaranteeing significant sdcs detected propose new method called hot rod solution problem checks potentially corrects data produced numerical integration solvers theoretical model shows significant sdcs detected present two detectors conduct experiments streamline integration wrf meteorology application compared algorithmic detection methods accuracy first detector increased similar false detection rate second detector false detection rate one order magnitude lower detection methods improving detection accuracy computational overhead lower cases model developed explicit runge kutta method although generalized solvers
work describes technique generating parametric surfaces meshes using parallel computing distributed memory processors technique used many areas computer graphics virtual reality among others input algorithm set parametric patches model surface given object structure spatial partitioning proposed decompose domain many subdomains processes parallel system subdomain consists set patches division load guided following estimate decomposition attempts balance amount work subdomains amount work known load mesh generator usually given function output size size generated mesh therefore technique estimate size mesh total load domain needed beforehand work makes use analytical average curvature calculated patch turn input data estimate load decomposition made analytical mean curvature domain decomposed process generates mesh subdomain set patches quadtree technique inner regions advancing front technique border regions finally applied improvement mesh generated technique presented good speed results keeping quality mesh comparable quality serially generated mesh
background hepatitis infectious liver disease high mortality rate caused hepatitis virus several treatment methods applied combat deadly virus including interferons vaccine direct acting antivirals daas however later shows promising effects hcv treatment lower adverse effect specifically daas target non structural proteins nsb purpose objective present study hypothesize alternative antiviral inhibitor hcv available antivirals methods computation molecular descriptors selected antiviral inhibitors followed clustering descriptor features closely clustered compounds subjected interaction studies hcv target protein validate cluster result results discussion clustering result showed indinavir hiv inhibitor hbv inhibitor molecule close hcv inhibitor indinavir complexed protein shows kcal mol complexed nsb protein possess binding energy kcal mol docking interaction study indicated better binding affinity viral inhibitors conclusion descriptor based feature similarity analysis interaction study concluded indinavir could potential alternative agent hcv treatment elsevier inc rights reserved
rectangular phase screen transmission model usually applied simulation optical propagation processes atmospheric turbulence paper analyze relationship fractal brownian motion atmospheric turbulence firstly based classical fractal algorithm new algorithm proposed generate rectangular phase screen combines random midpoint displacement rmd principle successive random additions sra technique mainly contains three interpolation methods including square interpolation trigonometric interpolation diamond interpolation respectively therefore call algorithm rmd sra carry split step method propagate beam atmospheric turbulence simulated rectangular phase screens transmission model numerical simulations show new algorithm traditional fft based algorithm statistical properties almost consistent theoretical value furthermore high performance computation time parallel efficiency
target classification algorithms generally kept pace developments academic commercial sectors since however recently investment object classification internet companies various human brain projects far outpaced defense sector implications noteworthy unique characteristics military classification problem target classification solely algorithm design problem part larger system design task design flows concept operations conops key performance parameters kpps inputs image signal data time synchronized metadata operation real time implementation minimizes size weight power swap output must conveyed time strapped operator understands rules engagement assumed adversary actively trying defeat recognition target list often mission dependent necessarily closed set may change daily basis highly desirable obtain sufficiently comprehensive training testing data sets costs high data certain target types scarce training data may representative battlefield conditions suggesting avoidance highly tuned designs number traditional emerging target classification strategies reviewed context military target problem
cash flow information crucial decision making process construction management due complexity dynamic progress construction project forecasting cash flow demand throughout various phases project remains challenging problem article presents novel inference model named adaptive timedependent least squares support vector machine svmat cash flow prediction svmat least squares support vector machine svm integrated adaptive time function atf generalize inputoutput mapping cash flow since cash flow data time dependent data points recorded different periods contribute dissimilarly training process prediction model thus role atf determine appropriate weight associated data point specific time period svmat better deal dynamic nature time series furthermore identify optimal parameters inference model differential evolution based cross validation process utilized research comparing benchmark methods proposed model identified appropriate time function yielded superior forecasting results therefore svmat promising tool construction managers cash flow prediction
purpose case report legionella pneumophlla pneumonia associated label use ustekinumab patient crohn disease presented summary year old man longstanding hospitalized four day history fever degrees dyspnea left pleuritic pain weight loss six weeks beginning treatment ustekinumab human monoclonal antibody approved united states two indications plaque psoriasis psoriatic arthritis currently investigation potential treatment inflammatory disorders preceding years man treated severe number agents infliximab adalimumab certolizumab ultimately label ustekinumab therapy subcutaneously weekly initiated due persistent severe symptoms chest ray studies time admission demonstrated left upper lobar consolidation urine antigen test positive pneumophlla patient treated levofloxacin methylprednisolone discharged two weeks ustekinumab reintroduced subcutaneously every two weeks patient continued receive drug months clinical remission symptoms adverse events literature search identified two case reports pneumonia associated ustekinumab use neither case involved pneumophila conclusion pneumonia caused pneumophila developed patient treated ustekinumab pneumonia symptoms resolved ustekinumab discontinued
purpose justice although well developed organisational field given adequate attention area construction project dispute negotiations based previous studies purpose paper elaborately discuss whether dimension justice distributive procedural interactional important negotiators cooperate construction project dispute negotiation whether impact moderated completeness construction contract design methodology approach survey prime negotiators different construction projects conducted stepwise multiple regression employed test impact dimension justice moderated multiple regression model used test moderating effect contract completeness findings results indicated distributive justice related cooperative behaviours impact procedural justice interactional justice also great impact even significantly related cooperative behaviours moreover contractual obligatoriness positively moderates relationship procedural justice cooperative behaviours term specificity negatively moderates relationship procedural interactional justice cooperative behaviours research limitations implications first authors aimed test effect justice cooperative behaviours construction dispute negotiations originally determine whether relationship mediated factors second contractual governance chosen moderator factors may also influence behaviours project dispute negotiations practical implications first project dispute negotiators focus attention solely distribution negotiation issues cooperative approach negotiators also give strong consideration whether offers reflect procedural justice whether opponents treated fairly second contractual design may affect frame surrounding negotiations help negotiators achieve integrated outcome give attention certain forms justice originality value contrast previous studies authors defined three forms justice project dispute negotiations adding three forms justice model authors attempted investigate whether distributive procedural interactional justice related cooperative behaviours project dispute negotiations ascertain extent form justice important furthermore authors explored variations importance form justice negotiations different contractual conditions
commencing medicare access chip reauthorization act macra change medicare pays health professionals enacting macra congress brought end sustainable growth rate formula also setting forth vision transform healthcare system clinicians deliver higher quality care smarter spending centers medicare medicaid services cms october cms released first stakeholders anticipate number annual rules related implementation macra cms received extensive input stakeholders including american geriatrics society quality payment program cms streamlined multiple medicare value based payment programs new merit based incentive payment system mips cms also outlined provide incentives participation advanced alternative payment models called apms although medicare payments geriatrics health professionals based new mips formula payments based upon performance day period article defines geriatrics health professionals clinicians care predominantly older adult population eligible bill medicare physician fee schedule given current paucity eligible apms article focus mips providing brief overview apms
histone deacetylases hdacs especially hdac abundantly expressed activated prostate cancer correlated poor prognosis thus inhibition hdac activity emerged potential alternative option prostate cancer therapy chromopeptide depsipeptide isolated marine sediment derived bacterium chromobacterium chemical structure highly similar class hdac inhibitor approved fda treating cell lymphoma study determined whether chromopeptide like acted class hdac inhibitor whether chromopeptide could inhibit growth migration human prostate cancer vitro vivo hdac enzyme selectivity kinetic analysis revealed chromopeptide selectively inhibited enzymatic activities hdac substrate non competitive manner comparable values hdac member vitro importantly chromopeptide dose dependently suppressed proliferation human prostate cancer cell lines lncap values nmol respectively accompanied dose dependent inhibition hdac enzymatic activity cells chromopeptide nmol caused phase arrest induced apoptosis prostate cancer cell lines moreover chromopeptide dose dependently inhibited migration cells mice bearing prostate cancer xenografts intravenous injection chromopeptide week significantly suppressed tumor growth associated increased expression levels tumor tissues results identify chromopeptide novel class hdac inhibitor provide therapeutic strategies may implemented prostate cancer
paper novel mixed iterative adaptive dynamic programming adp algorithm developed solve optimal battery energy management control problem smart residential microgrid systems based data load electricity rate two iterations constructed iteration iteration respectively iteration implemented based value iteration aims obtain iterative control law sequence period iteration implemented based policy iteration updates iterative value function according iterative control law sequence properties developed mixed iterative adp algorithm analyzed shown iterative value function monotonically nonincreasing converges solution bellman equation iteration proven performance index function finite iterative control law sequence finally numerical results comparisons given illustrate performance developed algorithm
moyamoya disease progressive occlusive pathology involving cerebral vasculature particular involvement circle willis tributaries cause moyamoya disease unknown believed hereditary females years old moyamoya represent acute cerebral ischemia infarcts risk factors including smoking estrogen containing birth control use coagulopathy neoplasm congenital malformation case reports year old puerto rican female soldier year history migraine headaches worsening right retro orbital pain blurred vision photophobia patient minimal unilateral neurological deficits despite evidence significant cerebral infarction non contrast computed tomography neuroimaging findings consistent moyamoya disease confirmation via cerebral angiography case details process diagnosis treatment well discussing incidence identification treatment options
objective temporal gradient patients korsakoff syndrome particular interest literature many studies found evidence steep temporal gradient others observed uniform remote memory impairment across past time periods inconsistencies might result nature remote memory impairment study nonpersonal autobiographical memory methodological differences examination remote memory loss aim study examine whether differences autobiographical memory interview ami autobiographical interview procedures influence presence temporal gradient semantic episodic autobiographical memory korsakoff patients method procedure used present study combined ami one study session compared performance patients korsakoff syndrome healthy controls first participants asked recall knowledge different life periods second participants asked recall memories five life periods thirdly participants asked rate subjective experience event recalled point scale finally analyzed findings terms memories recalled versus first memory life period results ami showed temporally graded retrograde amnesia korsakoff patients personal semantic episodic autobiographical memories pattern amnesia korsakoff patients affected examining one event per life period subjective ratings recalled memories largely comparable groups conclusions findings generally consistent across ami varying number events affect pattern gradient hence temporal gradient korsakoff patients artefact either ami method
hidden persistent malware guest virtual machine instances among common internal threats cloud computing affecting security cloud customers providers growing sophistication modern malware traditional methods becoming increasingly ineffective tackling cloud security problems moreover given pay per use model clouds consumption resources malwares malicious services cause huge losses cloud provider customer thus important develop mechanisms limit scale malicious attacks order minimize resources consumption trust management fundamental technique assessing increasing reliability security cloud services unfortunately majority existing mechanisms trust management clouds limitations prevent fully effective paper propose novel limited trust capacity model mitigate threats internal malicious software services cloud computing using concepts flow networks reduce scale malicious software services limited trust capacity model utilized following two ways manage trust relationship among guest services evaluate threats unknown malicious services minimize risk associated renting cloud services limiting resource drain caused malicious guest services finally experimental results show limited trust capacity model effectively restrict scale malicious services significantly mitigate threats internal attacks
objectives research limited psychiatrists opinions concepts internet gaming disorder igd problematic internet use piu aimed assess health literacy among psychiatrists igd piu methods self report survey administered online members royal australia new zealand college psychiatrists ranzcp results majority familiar concepts igd piu majority thought possible addicted non gaming internet content thought non gaming addictions could possibly included classificatory systems forty eight felt igd maybe common practice felt confident managing igd child psychiatrists likely screen routinely igd fishers exact test chi likely elicit specific symptoms addiction fishers exact test chi conclusions recommend adoption terms alternate piu igd line content material irrespective medium access screening instruments protocols needed assist early diagnosis service planning barriers screening would need addressed research service settings
jacobian matrix algorithm often used calculate lyapunov exponents chaotic systems study extends algorithm discrete fractional cases tangent maps memory effect presented lyapunov exponents one two dimensional fractional logistic maps calculated positive ones used distinguish chaotic areas maps elsevier rights reserved
geometrical shock dynamics gsd theory appealing method predict shock motion sense computationally efficient solving traditional euler equations especially converging shock waves however solve optimize large scale configurations main bottleneck computational cost among existing numerical gsd schemes one implemented parallel computers purpose analyze detonation waves extend computational advantage gsd theory general applications converging shock waves numerical implementation using spatial decomposition method coupled front tracking approach parallel computers addition efficient tridiagonal system solver massively parallel computers applied resolve expensive function implementation resulting efficiency using hpcc cores moreover symmetric boundary conditions developed reduce computational cost achieving speedup sided polygonal converging shock elsevier rights reserved
paper focuses recently announced modern programmable smart residential thermostats smart homes contribute better energy usage households explores people motivation using technologies actually use much energy save based producer experimental measurements
obstructive sleep apnea syndrome osas common disorder subjects osas prevalence hypothyroidism approximately episodes hypoxia reoxygenation associated respiratory disturbances observed subjects osas increases risk cardiovascular diseases hypothyroidism primary subclinical several effects cardiovascular system study investigated carotid artery intima media thickness imt early sign atherosclerosis osas subjects hypothyroidism subjects admitted kahramanmaras necip faza city state hospital chest diseases patient clinic may january snoring polysomnographic evaluation sleep laboratory included study subject evaluated serum thyroid function tests carotid artery imt measured doppler ultrasound mean carotid artery imt values isolated osas osas plus hypothyroidism control groups respectively difference groups statistically significant poxsitive correlation found thyroid stimulating hormone levels imt free levels imt negatively correlated imt apnea hypopnea index also positively correlated suggest physicians alert hypothyroidism comorbidity osas suspected subjects osas screened hypothyroidism considering potential cardiovascular complications
aiming low frequency oscillation traction network caused high speed railway electric motor units emus transient current control strategy tccs based traditional controller adopted line side converter lsc emus analyzing controller parameter adjustment found suppression measure limitations order overcome problem paper brings internal model control imc tccs according internal model control principle two degree freedom dof internal model controller designed replace traditional controller tccs comparing performance characteristics tccs based traditional controller tccs based dof imc finally emus adopting two control strategies applied time domain simulation model train grid respectively found tccs based dof imc provides better tracing load disturbance regulation characteristics addition able suppress low frequency oscillation high speed railway traction network effectively
backgroundeight new loci type diabetes mellitus tdm identified east asian genome wide association study meta analysis assess tag snps across loci associations tdm american indians methodsa total snps tag common variation across loci analyzed association tdm early onset tdm body mass index insulin sensitivity insulin secretion resultstag snps within fitm rhdml hnfa glis kcnk zfand associated tdm accounting locus wide multiple testing tdm association fitm rhdml hnfa independent east asian lead snp associate tdm american indians top signals glis kcnk attenuated adjustment east asian lead snps glis kcnk also associated tdm american indians respectively top snp zfand identical east asian lead snp additional snps glis zfand significant genotypexsex interactions glis snp associated tdm men zfand snps associated tdm women respectively conclusionsreplication lead tdm snps glis kcnk zfand observed american indians sex specific tdm signals glis zfand distinct east asian gwas signals also identified
objective review compare epidemiology treatment mandibular fractures subgroups pediatric population methods conducted retrospective review pediatric patients age years mandibular fractures treated institution january november results identified patients male mandibular fractures prevalent mechanisms injury motor vehicle accidents sports injuries assault common fracture sites subcondylar parasymphyseal angle body two patients treated conservatively observation underwent maxillomandibular fixation alone underwent maxillomandibular fixation plate fixation underwent plate fixation average duration maxillomandibular fixation days range days complications occurred patients mean follow days range days fifty patients comorbid conditions history mental illness time injury including attention deficit hyperactivity disorder mental disorders attention deficit hyperactivity disorder asthma twenty six patients history substance use common tobacco alcohol marijuana conclusions treatment approach outcomes affected age fracture characteristics addition marked proportion cohort preexisting mental disorders history substance use may implications treatment approach elsevier ireland ltd rights reserved
objectivethis study aims determine whether prevalence lifetime past month dsm eating disorders diagnoses differed body mass index category among men women general population sample methodsdata collaborative psychiatric epidemiology surveys adults analysed using logistic regression analyses conducted separately gender resultslifetime prevalence men women genders prevalence lifetime past month binge eating disorder recurrent binge eating highest among obese individuals among obese men women lifetime past month prevalence highest among class iii obesity conclusioneating disorders prevalent among high weight individuals information important planning targeted public health obesity prevention intervention activities well informing clinical care obese individuals copyright john wiley sons ltd eating disorders association
squeezed budgets funding cuts expected become feature healthcare landscape future forcing decision makers service managers clinicians commissioners find effective ways allocating scarce resources paper discusses development decision support toolkit dst facilitates improvement services identifying cost savings efficiencies within pathway care help national health service commercial experts developed discrete event simulation model deep vein thrombosis dvt patients adapted socio technical allocation resources star approach answer crucial questions like sort interventions spend money get value investment explain choices made dst enables users model services working dst interface allowing users specify local dvt services input local estimates data service demands capacities thus creating baseline discrete event simulation model user compare baseline potential changes patient pathway safety virtual environment making changes key decision makers easily understand impact activity cost staffing levels skill mix utilisation resources importantly allows find interventions highest benefit patients provide best value money
purpose popular media movies reflect contribute changes cultural norms values examined gender differences trends portrayal sexual violent content top grossing films methods sample included top grossing films released years number female male main characters involvement sexual violent behavior coded analyzed time relationships sexual violent behavior within films also assessed results average number male female main characters films remained stable time male characters outnumbering female characters two one female characters twice likely male characters involved sex differences explicit sex growing time violence steadily increased male female characters conclusions although women continue underrepresented films disproportionate portrayal explicit sexual content grown time portrayal violent roles also grown rate men implications exposure trends among young movie going men women discussed society adolescent health medicine rights reserved
subclinical hypothyroidism associated hypercoagulability hypofibrinolysis objective study assess effect thyroxine treatment evaluate changes hemostatic abnormalities patients varying severities measured tissue plasminogen activator plasminogen activator inhibitor pai dimer ddi fibrinogen fib platelet counts plt mean platelet volume mpv platelet distribution width pdw activated partial thromboplastin time aptt prothrombin time female subjects prospective study included patients control group patients tsh mild patients tsh severe patients tsh value given replacement therapy titrated normalize tsh levels significant differences triglyceride total cholesterol low density lipoprotein cholesterol ldl serum uric acid levels mpv pdw aptt fib pai ddi measurements among three groups data tested using least significant difference method multiple comparisons patients severe group showed higher fib pai levels lower ddi levels shorter aptt compared control group whereas hemostatic parameters mild patients different compared control group months treatment significant decrease fib pai levels increase aptt ddi observed severe group conclusion patients displayed distinct pattern alteration hemostatic parameters dependent severity disease patients tsh levels displayed hypercoagulability reversed months treatment
purpose goal study assess whether common measurements patellar trochlear morphology patellar alignment associated central cartilage lesions patella trochlea using magnetic resonance imaging mri methods mri examinations patients women men mean age years range years central cartilage lesions patella trochlea retrospectively compared obtained control subjects women men mean age years range years patients modified noyes classification grade iia iib iii cartilage defects whereas control subjects normal mri examination knee determined two radiologists patellar measurements facet asymmetry patellar tilt lateral patellofemoral angle insall salvati ratio patellotrochlear cartilage overlap performed patients control subjects along trochlear measurements trochlear depth width sulcal angle multivariate logistic regression adjusted age body mass index used assess associations results ratio lengths medial lateral facets patella angle median eminence patella lateral patellofemoral angle insall salvati ratio edema superolateral aspect hoffa fat pad significantly associated central cartilage lesions patella trochlea conclusion central cartilage lesions patellofemoral joint associated patellarand trochlear morphology patellar alignment editions francaises radiologie published elsevier masson sas rights reserved
people living hiv aids pha often concurrently cope mental health disorders may greatly influence hiv health related outcomes objective study examine prevalence correlates self reported mental health disorder diagnosis among cohort harder reach hiv positive individuals british columbia canada pha initiated art enrolled longitudinal investigation supportive ancillary health services lisa study socio demographic behavioral health care utilization psychosocial information collected interviewer led questionnaires linked longitudinal clinical variables provincial drug treatment program centre excellence hiv aids identified prevalence type specific mental health disorders among population participants included analysis reported ever mental health disorder diagnosis mood anxiety disorders two frequently reported mental health conditions self reported type mental health disorder independently associated decreased overall functioning adjusted odds ratio aor confidence interval life satisfaction aor higher stigma score aor participants reporting mental health disorder likely report history sexual assault aor used case management services aor findings uncovered high burden mental health disorders among harder reach pha suggest pha least one mental health disorder diagnosis disproportionately impacted sexual violence stigma
paper concerns use digital storytelling mathematics education competence based methodology seems well apt improve students capabilities active solvers real world problems according pisa framework present storytelling model takes account research results storytelling pedagogical area story problems mathematics education according model present use case consisting implementation prototype latter made available regional school office campania south italy context project support schools activities regarding mathematical literacy finally report early students perceptions discuss constraints limits prototype
magnetite feo important material due unique physical chemical properties however low redox stability tendency towards oxidation impose certain limitations conditions feo successfully used possibility control prevent oxidation feo thus represents important challenge materials engineering present work laser floating zone lfz method employed produce feo fibres using hematite feo precursor material different growth conditions namely pulling rate range studied prepared fibres showed core shell structure core isolated shell feo pulling rate found crucial growth parameter control crystalline nature fibres particularly thickness shell increasing pulling rate favours formation feo phase thus decreases width shell isolating phase ray diffraction xrd analysis performed identify presence feo feo phases morphology phase distribution grown fibres analyzed optical microscopy electrical properties fibres measured various temperatures understand influence pulling rate fibres shell vibrating sample magnetometer vsm measurements used study magnetic susceptibility hysteresis curves behaviour feo phase temperature range elsevier rights reserved
objective purpose pilot study implement evaluate self care skills training solution focused counselling support psychiatrists handling daily work challenges methods total psychiatrists working psychiatric clinic randomised single blind trial either intervention group control group outcomes measured baseline end training follow months follow months validated questionnaire including perceived stress questionnaire copenhagen psychosocial questionnaire brief resilient coping scale self efficacy scale quality relationship inventory used results psychiatrists intervention group reached significant reduction perceived job stress improvements job satisfaction resilience self efficacy baseline follow ups comparable results seen control group psychiatrists stated improved quality physician patient relationship support conflict management conclusions self care skills training including solution focused counselling psychiatrists associated significant improvements perceived stress job satisfaction individual protective skills quality relationship patients training suitable implement group training program psychiatrists
facial composite construction one successful applications interactive evolutionary computation spite previous work area composite construction investigated algorithm design options detail address issue four experiments first experiment sorting task used identify salient dimensions dimensional search space second experiment performances two mutation two recombination operators interactive genetic algorithms compared third experiment three search spaces compared dimensional search space mathematically reduced dimensional search space dimensional search space formed salient dimensions finally compare performances interactive genetic algorithm interactive differential evolution results show facial composite construction process remarkably robust choice evolutionary operator dimensionality search space choice interactive evolutionary algorithm attribute imprecise nature human face perception differences participants interact algorithms
first part article describe variety cases involved led becoming expert witness cases range questions children memory raped remembering ear witnessed murder preventing future false memories second part article reflect remarkable feats remembering complainants exhibit court ones contradict much scientific study memory shown true along way argue scientific knowledge becomes part culture memory familiar triers fact judges jurors police laypeople memory experts continue inexorable part legal process memory serves main evidence
etiology underlying mechanisms pregnancy associated osteoporosis pao still unknown since systematic analyses exist results indicate pao heterogeneous rare severe disease including substantial number fractures significant delay first symptom diagnose pregnancy associated osteoporosis pao rare severe type premenopausal osteoporosis common symptom includes acute lower back pain due vertebral fracture predominantly occurring last trimester pregnancy immediately postpartum exact underlining mechanisms risk factors pao still unknown date published systematic analyses identified pao patients matched healthy controls according age region gravidity evaluate risk factors large homogenous population women baseline characteristics anthropometric data two study groups similar eighty eight percent patients pao suffered one fractures mean fractures per patient common fracture site thoracolumbar spine whereas patients reported fractures respectively pao patients suffered frequently excessive dental problems childhood control group performed significantly frequently sports puberty compared controls patients pao reported twice often severe diseases pregnancy hereby frequency immobilization twice often pao group compared control group results indicate pao heterogeneous rare severe disease including substantial number fractures significant delay first symptom diagnose increased awareness warranted immediately start effective treatment
article details control light emitting diodes leds using ordinary desktop computer combining digitally addressable leds shelf microcontroller arduino multiple leds controlled independently high degree temporal chromatic luminance precision proposed solution safe powered battery tested used published research inexpensive similar per led highly interoperable controlled type computer operating system via usb bluetooth connection requires prior knowledge electrical engineering components simply require plugging together uses widely available components established help forums already exist matlab code provided including minimal working example use suitable use beginners properties recommended leds also characterized including response time luminance profile color gamut based shown leds highly stable terms luminance chromaticity suffer issues warm chromatic shift slow response times associated traditional crt lcd monitor technology
solar power become attractive alternative source energy multi crystalline solar cell widely accepted market relatively low manufacturing cost multi crystalline solar wafers larger grain sizes fewer grain boundaries higher quality convert energy efficiently mono crystalline solar cells article new image processing method proposed assessing wafer quality adaptive segmentation algorithm based region growing developed separate closed regions individual grains using proposed method shape size grain wafer image precisely evaluated two measures average grain size taken literature modified estimate average grain size resulting average grain size estimate dictates quality crystalline solar wafers considered viable quantitative indicator conversion efficiency
background hiv aids considered chronic disease quality life qol become important focus researchers healthcare providers technology mediated interventions demonstrated improved clinical effectiveness outcomes viral suppression persons living hiv aids plwh however evidence support impact interventions qol lacking objectives aim paper assess impact technology mediated interventions qol identify instruments used measure qol plwh methods review followed prisma guidelines literature search conducted pubmed cinahl cochrane embase databases april inclusion criteria limited articles technology mediated interventions compared usual care articles population defined hiv infected patients articles qol measured health outcome randomized controlled trials cochrane collaboration risk bias tool used assess study quality results peer reviewed articles returned searches met inclusion criteria systematic review identified four types technology mediated interventions two types qol instruments used examine impact technology mediated interventions plwh four studies technology mediated interventions resulted improvement qol four studies considered qol secondary outcome resulted negative neutral impact qol overall four studies low risk bias one study moderate risk bias five studies high risk bias conclusions evidence support improvement qol using technology mediated interventions insufficient lack research highlights need increased study qol outcome measure need consistent measures better understand role technology mediated interventions improving qol plwh
computational models word recognition already successfully used associative spreading orthographic semantic levels account false memories also account semantic effects event related potentials recognition memory task address question target words present study either many semantic associates stimulus set found larger amplitudes smaller amplitudes old words comparison new words words many semantic associates led larger amplitudes smaller comparison words smaller number semantic associations also obtained inverted response time accuracy effects old new words faster response times fewer errors found old words many semantic associates whereas new words large number semantic associates produced slower response times errors behavioral electrophysiological results indicate semantic associations words facilitate top driven lexical access semantic integration recognition memory results support neurophysiologically plausible predictions associative read model suggests top connections semantic orthographic layers elsevier rights reserved
introduction lithium drug choice treatment bipolar affective disorder objective define lithium therapeutic profile adverse reactions use patients bipolar affective disorder colombia materials methods conducted observational retrospective cohort study january december included patients diagnosis bipolar disorder treated lithium carbonate colombian cities evaluated socio demographic variables lithium dose medication drug interactions adverse reactions multivariate analysis done using spss results patients average age years women mean dose lithium day received doses lower recommended patients received lithium months range months lithium levels blood measured patients received adjuvant therapy bipolar disorder drugs especially clozapine valproic acid main comorbidities hypothyroidism hypertension potentially toxic drug interactions found adverse reactions reported patients statistically significant association found lower risk combination therapy receiving treatment cities bogota cartagena ibague conclusion lithium generally used recommended doses intervals significant percentage patients received lower doses recommended possible compare lithium levels blood adverse reactions blood lithium levels reporting improved patients bipolar disorder colombia
exergy life cycle assessment elca proposed literature account exergy embodied products energy systems order make results elca comparable supply chains support life cycle system analyzed unified model one main concerns related life cycle assessment industrial ecology disciplines paper hybrid input output analysis proposed computational structure elca according method national supply chains modeled monetary input output tables miots national economies constantly updated freely available data source adopted national miot expanded include detailed model considered energy system hence defining hybrid input output model non renewable exergy embodied electricity production exergy return investment exroi defined appropriate performance indicators based elca introduced model adopted analysis waste energy wte power plant currently operating italian context found primary non renewable exergy embodied electricity produced analyzed wte non negligible construction toe operation phases toe nonetheless plant able produce net amount electricity pays back primary non renewable resources requirements hundred times finally joint application exergy analysis elca lead improve overall thermodynamic performances wte system increasing exergy efficiency reducing non renewable exergy embodied electricity production toe elsevier ltd rights reserved
background suicidal behavior reported associated seasonality chronotype however study reported suicidality according chronotype seasonality patients major depressive disorder mod study evaluated relationship suicidality biological rhythm patients mod methods total patients nidd participated evaluated seasonal patterns chronotypes morningness wake early best first part day eveningness feel best alert late hours suicidal ideations clinical variables including symptom severity results patients seasonality showed significantly higher suicidal ideation patients without seasonality compared morning type participants evening type participants showed higher suicidality suicidal ideation positively correlated eveningness tendencies hypomanic personality traits limitations first analyze causal relationship biological rhythm suicidality secondly suicidal ideation cases reflect actual attempt lastly categorize seasonal pattern summer winter type conclusions findings suggest biological rhythm significantly associated suicidal ideation patients mdd elsevier rights reserved
efficient precise real time video based vehicles supervision systems traffic surveillance ever demanding developing accurate detection tracking algorithm incorporating effects vehicles shadow visual obstacles occlusion including road signs trees vehicles challenging task propose new approach efficient detection tracking moving vehicles presence shadow partial occlusion complex road scenes combining modified background subtraction innovative adaptive search window methods use variable size window bounding box reduces searching space proportional allocated time moving vehicles first background model constructed subtracted subsequent traffic frames distinguish foreground objects moving vehicles regions stable background regions finally shadow detection occlusion handling moving vehicles implemented leverage surveillance performance performance proposed method benchmarked using baseline highway category changedetection net standard dataset frames performance evaluation carried terms time complexity analysis detection accuracy processing time experimental results demonstrate radical reduction computational time terms searched space superior detection accuracy processing time per frames milliseconds together time complexity degree achieved excellent features results suggest proposed approach prospective computer vision application high way traffic surveillance
objectives describe sleep duration sleep characteristics examine associations sleep duration characteristics body weight status diet quality physical activity levels among grade children nova scotia methods provincially representative sample grade children parents nova scotia surveyed parents asked report child bedtime wake time indicate often child snored felt sleepy day dietary intake physical activity self reported children using harvard youth adolescent food frequency questionnaire physical activity questionnaire children respectively body weight status determined using measured heights weights linear logistic random effects models children nested within schools used test associations results approximately half surveyed parents reported children getting adequate sleep night longer sleep duration statistically significantly associated decreased risk overweight obesity independent sleep characteristics longer sleep duration also associated better diet quality higher levels physical activity conclusions findings indicate need health promotion strategies encourage adequate sleep promote healthy sleep environments among children given links among sleep body weight status lifestyle behaviours messages included public health interventions aimed preventing obesity promoting health among children
dysfunction orbitofrontal ofc anterior cingulate acc cortices linked several psychiatric disorders including obsessive compulsive disorder major depressive disorder posttraumatic stress disorder addiction conditions also associated abnormalities anterior limb internal capsule white matter bundle carrying ascending descending fibers ofc acc furthermore deep brain stimulation dbs psychiatric disorders targets fibers experiments rats provide essential information mechanisms normal abnormal brain anatomy including composition perturbations however whereas descending prefrontal cortex pfc fibers primates form well defined topographic anterior limb internal capsule specific locations organization fibers rats unknown address gap analyzing descending fibers injections anterograde tracer rat acc ofc results show descending pfc fibers rat form fascicles embedded within striatum bundles arranged topographically contain projections striatum also thalamus brainstem therefore viewed rat homolog primate anterior limb internal capsule furthermore mapping projections allows identify fibers likely affected experimental manipulations striatum anterior limb internal capsule results therefore essential translating abnormalities human effects dbs rodent models
accountability mechanisms help governments development partners fulfill promises commitments make global initiatives millennium development goals global strategy women children health regional national strategies campaign accelerated reduction maternal mortality africa carmma without directed pressure comparative data tools provide insight successes failures overall results accountability fails analysis accountability mechanisms five countries supported evidence action program shows accountability effective connected across global national levels civil society central independent role proactive immediate targeted implementation mechanisms funded start advocacy accountability combined local outreach activities blood drives local national champions presidents first ladies ministers help draw public attention government performance scorecards developed provide insight performance highlight necessary improvements politicians subnational level supported national leaders effect change sustainable development goals accountability advocacy supported global regional intergovernmental organizations constantly monitored commensurate retribution nonperformance remain essential international federation gynecology obstetrics published elsevier ireland ltd
water pollution various toxic contaminants become one serious problems worldwide various technologies used treat water waste water including chemical precipitation ion exchange adsorption membrane filtration coagulation flocculation flotation electrochemical methods past decades nanotechnology gained wide attention various nanomaterials developed water remediation present review article various nanomaterials reviewed used water decontamination special emphasis review given adsorption photocatalytic antibacterial activity nanomaterials elsevier rights reserved
recent years research conducted close collaboration manufacturers design robust profitable dismantling systems thus engineers designers new products consider constraints disassembly specifications design phase products context end life precisely product life cycle consequently optimization disassembly process complex products essential case preventive maintenance fact disassembly sequence plan dsp among combinatorial problems hard constraints practical engineering becomes hard problem research work automated dsp process based metaheuristic method named ant colony optimization developed beginning computer aided design cad model collision analysis performed identify possible interferences components motion interference matrix generated identify dynamically disassembly parts ensure feasibility disassembly operations novelty developed approach presented introduction new criteria maintainability usury component several criteria volume tools change disassembly directions change finally highlight performance developed approach implemented tool developed industrial case studied obtained results prove satisfactory side criteria identify feasible dsp record time
early diagnosis social isolation older adults prevent physical cognitive impairment diagnosis usually consists personal periodic application psychological assessment instruments unfortunately often tedious process therefore situation opens opportunities creating new ways diagnosis context ambient intelligence social networking sites suitable technologies automatic monitoring significant changes social interactions older adults however current instruments measure social isolation based subjective aspects since evaluate emotional social support consider objective aspects reason prediction model based objective isolation variables needed order measure social interactions computing mechanisms paper presents development prediction model social interaction activities registered smartphone sensory capabilities personal communications using online social network also radio frequency identification mechanisms proposed model benefit institutions interested developing technological solutions detect early stages social isolation improve quality life older adults
background failure rates knee ligament surgery may high impact osseous alignment surgical outcome remains controversial basic science studies demonstrated osseous malalignment negatively affect ligament strain realignment procedures may improve knee joint stability hypothesis purpose purpose review summarize clinical evidence concerning impact osseous malalignment realignment procedures knee ligament surgery hypotheses lower extremity malalignment would important contributor knee ligament surgery failure realignment surgery would contribute increased knee stability improved outcome select cases study design systematic review level evidence methods according prisma preferred reporting items systematic reviews meta analyses guidelines systematic electronic search pubmed database performed november identify clinical studies investigating influence osseous alignment postoperative stability failure rates knee ligament surgery impact osseous realignment procedures unstable knees without additional knee ligament surgery postoperative knee function stability methodological quality studies assessed using oxford centre evidence based medicine levels evidence coleman methodological score cms results potentially relevant articles studies fulfilled inclusion exclusion criteria average study quality poor cms part studies showed increased rerupture rate anterior cruciate ligament acl replacement patients increased tibial slope concerning posterior cruciate ligament pcl posterolateral corner plc lateral collateral ligament lcl varus malalignment considered significant risk factor failure part studies showed decreased anterior tibial translation slope decreasing high tibial osteotomy acl deficient knees correcting varus malalignment pcl plc lcl instability also showed increased stability better outcomes conclusion cases complex knee instability dimensional osseous alignment knee considered mechanical weightbearing line tibial slope cases failed acl reconstruction tibial slope considered slope reducing osteotomies often helpful patient revised multiple times cases chronic pcl plc instability osseous correction varus alignment may reduce failure rate often first step treatment changes mechanical axis considered cases instability accompanied early unicompartmental osteoarthritis
importance insect cuticle primary protective barrier entomopathogens long noted present study addressed issue utilizing experimental infection system composed model beetle castaneum two entomopathogenic fungal species beauveria bassiana metarhizium anisopliae pupae relatively susceptible fungi natural route infection refractoriness developed age adults exhibited much higher refractoriness whereas anisopliae exhibited seemingly higher infectivity pupae compared bassiana natural conidium infection employed direct inoculation cultured hyphal body cells hemocoel found highly equally virulent pupae fungal species results collectively suggest important role cuticular integument antifungal host defense subsequently conducted knockdown chitin synthase gene chs targeted prepupal mid pupal peaks expression respectively using injection dsrna low dosages avoid lethality resulting pupae looked normal adults showed mild phenotype dimpled wrinkled elytra chs gene knockdown compromised significantly host defense fungal infection via natural route except configuration knockdown pupae anisopliae suggesting indispensable role chs elsevier inc rights reserved
previous research shown media violence exposure cause desensitization violence theory increase aggression however study date demonstrated association present experiment participants played violent nonviolent video game viewed violent nonviolent photos brain activity measured gave ostensible opponent unpleasant noise blasts participants low previous exposure video game violence played violent relative nonviolent game showed reduction component event related brain potential erp violent images indicating physiological desensitization brain response mediated effect video game content subsequent aggressive behavior data provide first experimental evidence linking violence desensitization increased aggression show neural marker process least partially account causal link violent game exposure aggression elsevier inc rights reserved
nowadays important diagnose several kinds pathologies early stage order take necessary countermeasures permanent consequences unfortunately though many pathologies widespread exist unique standardized reference gold standard according possible evaluate patients mainly pathology early stages noticeable doctor sufficiently expert problem domain work deal problem envisioning new healthcare services supporting collaborative clinical analysis symptoms collected patients forwarded group experts geographically distributed experts return back assessment diagnosis system combines means theory evidence order provide single response services easily implemented top state art distributed computing facilities grids clouds providing connected environment medical data distributed different sites allowing medical experts collaborate without located thereby providing transparent access data computing resources additionally services provide feedbacks expert order improve knowledge experience case divergence expert response global combined diagnosis recognizing classifying received symptomatic indexes patient considered craniofacial pathologies infant population practical example better explaining proposed solution elsevier rights reserved
purpose project examine emotional health wellbeing canadian caregivers persons significant mental health addictions problems assessed emotional health caregivers care receiver condition type mental health addictions physical health problems levels caregiver stress methods particularly reducing stress among caregivers persons mental health addictions disorders weighted cross sectional data general social survey caregiving care receiving modelled using weighted descriptive logistic regression analyses examine levels stress emotional health well caregivers care receiver condition type caregivers persons mental health addictions problems likely report caregiving stressful felt depressed tired worried anxious overwhelmed lonely isolated short tempered irritable resentful caregiving responsibilities results study suggest mental health addictions caregivers may experience disparate stressors require varying services supports relative caregivers persons physical health conditions
vibration based structural health monitoring changes natural frequency structure used identify changes structural conditions due damage deterioration however natural frequency values also vary changes environmental factors temperature wind therefore important differentiate effects due environmental variations resulting structural damage paper task accomplished predicting natural frequency structure using measurements environmental conditions five methodologies multiple linear regression artificial neural networks support vector regression regression tree random forest implemented predict natural frequencies tamar suspension bridge using measurements taken years continuous monitoring effects environmental factors traffic loading natural frequencies also evaluated measuring relative importance input variables regression analysis results show support vector regression random forest ate suitable methods predicting variations natural frequencies addition traffic loading temperature found two important parameters need measured results show potential application continuously monitored structures complex relationships natural frequencies parameters loading environmental factors elsevier ltd rights reserved
diosgenin steroidal sapogenin natural origin demonstrated benefits comes treatment malignancies cardiovascular issues menopausal symptoms study investigated histological changes adrenal gland diosgenin application rat model menopause middle aged acyclic female wistar rats divided control diosgenin treated groups diosgenin day orally administered four weeks group received vehicle alone histological approach included design based stereology histochemistry immunohistochemistry adrenal cortex volume decreased females volume adrenal medulla increased compared parameters group volume density zona glomerulosa expressed per absolute adrenal gland volume rats increased comparison animals diosgenin treatment decreased volume density zona fasciculata expressed per volume adrenal cortex compared females absolute volume zona reticularis group decreased comparison parameter rats also diosgenin application volume density zona reticularis expressed per volume adrenal cortex zona reticularis cell volume decreased respectively compared animals results reflecting decrease many stereological parameters adrenal cortex indicate diosgenin took role corticosteroid precursors became incorporated steroidogenesis elsevier gmbh rights reserved
theoretical frameworks regarding role life stress bipolar disorders incorporate possibility changing relationship psychosocial context episode initiation across course disorder kindling hypothesis theorizes longitudinal course recurrent affective disorders relationship major life stressors episode initiation declines post present study aimed test extension kindling hypothesis examining effect early life adversity relationship proximal life events prospectively assessed mood episodes data bipolar participants female caucasian mean age years years collected part temple wisconsin longitudinal investigation bipolar spectrum project bipolar cyclothymic disorder participants completed self report measure early adversity baseline interview assessed mood episodes life events regular month follow ups results indicate early childhood adversity sensitized bipolar participants effects recent stressors depressive episodes hypomanic episodes within particularly case minor negative events current study extends prior research examining kindling model using methodologically rigorous assessment life stressors mood episode occurrence clinicians assess experiences early adversity individuals may impact reactivity developing depressive episodes response future stressors
introduction efforts made continue increase safety contraceptive methods without estrogen attracted new attention progestin options available many delivery systems cause disturbed bleeding patterns gynecologic patients selective progesterone receptor modulators sprms approved medical abortion ovulation suppression emergency contraception treatment heavy menstrual bleeding due leiomyoma areas covered article discusses role sprms controlling fertility ongoing basis particular emphasis mifepristone ulipristal acetate upa since none compounds progressed early phase testing also discusses important information mechanisms action safety two sprms expert opinion investigational hormone agonist antagonists sprms demonstrated greatest potential ongoing female contraceptives ability suppress ovulation initiation luteinizing hormone surge without affecting ovarian production estrogen inducing significant metabolic changes sprms may well able provide longer term contraception oral agents vaginal rings perhaps even intrauterine devices upa greatest promise current research needs expanded
viewing indirect aggression television shown negative short term effects viewer subsequent aggressive behavior however longer term relationship viewing indirect aggression television real life yet examined three hundred forty seven adolescents aged asked list five favorite television programs programs analyzed amount type aggression contained peer nominated indirect aggression predicted aggressive behavior sex televised indirect aggression particular indirectly aggressive girls viewed indirect aggression television group peer nominated physical aggression predicted aggressive behavior sex televised physical indirect aggression study provides starting point future long term research effect viewing indirect aggression media
nowadays image processing machine vision fields become important research topics due numerous applications almost every field science performance fields critically dependent quality input images imaging devices optical lenses used capture images particular scene due limited depth field optical lenses objects different distances focal point captured different sharpness details thus important details scene might lost regions multi focus image fusion effective technique cope problem main challenge multi focus fusion selection appropriate focus measure paper propose novel focus measure based surface area regions surrounded intersection points input source images potential measure distinguish focused regions blurred ones proved fusion algorithm intersection points input images calculated input images segmented using intersection points surface area segment considered measure determine focused regions using measure obtain initial selection map fusion refined morphological modifications demonstrate performance proposed method compare results several competing methods results show effectiveness proposed method elsevier rights reserved
objective lactating women infants susceptible iodine deficiency iodine excess south africa data exist iodine status thyroid function vulnerable groups methods cross sectional study urinary iodine concentrations uic thyroid function breast milk iodine concentrations bmic assessed lactating women south african township month old breastfed infants potential predictors uic thyroid function bmic including household salt iodine concentrations sic maternal sodium excretion also investigated results median percentile uic infants mothers median household sic ppm household sic maternal urinary sodium excretion predicted uic lactating mothers median bmic age infants sic maternal uic predicted bmic turn infant age bmic predicted uic infants forty two percent sic values within south african recommended salt iodine fortification level production ppm whilst sic ppm thyroid stimulating hormone total thyroxine thyroglobulin concentrations dried whole blood spot specimens infants mmol respectively correlate infant uic bmic conclusion results suggest salt fortification program south africa provides adequate iodine lactating women indirectly infants via breast milk however monitoring salt iodine content mandatory salt iodization program south africa important avoid iodization salt
trie one data structures keyword search algorithms utilized natural language processing reserved words search compilers double array louds efficient representation methods trie double array provides fast traversal time complexity space usage double array larger louds louds succinct data structure bit string space usage extremely compact however traversal speed fast paper presents new compression method double array keeping retrieval speed new method compresses double array dividing double array blocks using linear functions experimental results varied keywords show new method reduced space usage double array retrieval speed new method times faster louds moreover results show construction speed new method faster conventional method large keyword set
purpose review chronic hepatitis virus hbv hepatitis virus hcv infections hiv hbv hcv coinfection major causes chronic liver disease worldwide testing diagnosis gateway access treatment prevention services remains large burden undiagnosed infection globally review global epidemiology key challenges current hepatitis testing response new tools support hepatitis global response global hepatitis health sector strategy guidelines hepatitis testing future directions innovations hepatitis diagnostics recent findings key challenges current hepatitis testing response include lack quality assured serological low cost virological vitro diagnostics limited facilities testing inadequate data guide country specific hepatitis testing approaches stigmatization risk viral hepatitis lack guidelines hepatitis testing resource limited settings new global hepatitis health sector strategy sets goals elimination viral hepatitis public health threat gives outcome targets reductions new infections mortality well service delivery targets include testing diagnosis treatment hepatitis testing guidelines adults adolescents children low income middleincome countries outline public health approach strengthen expand current testing practices viral hepatitis addresses test testing approaches serological virological assays use testing strategies well interventions promote linkage prevention care summary future directions innovations hepatitis testing include strategies improve access use existing facility community based testing opportunities hepatitis testing near patient pointof care assays virological markers nucleic acid testing hcv core antigen dried blood spot specimens used different serological nucleic acid test assays multiplex multi disease platforms enable testing multiple analytes pathogens potential self testing viral hepatitis
patchy distribution atherosclerosis within arteries widely attributed local variation haemodynamic wall shear stress wss recently introduced metric transverse wall shear stress transwss average cardiac cycle wss components perpendicular temporal mean wss vector correlates particularly well pattern lesions around aortic branch ostia use numerical methods investigate nature arterial flows captured transwss sensitivity transwss inflow waveform aortic geometry transwss developed chiefly acceleration peak systolic deceleration phases cardiac cycle reverse flow phase short wss diastole low periods significant influence spatial variation transwss arose variation angle instantaneous wss vectors deviated mean wss vector rather variation magnitude vectors pattern transwss insensitive inflow waveform unphysiologically high womersley numbers produced substantial changes however transwss sensitive changes geometry curvature arch proximal descending aorta responsible principal features non planar nature aorta produced asymmetries location position streaks high transwss taper determined persistence streaks aorta results reflect importance fluctuating strength dean vortices generating transwss elsevier ltd published elsevier ltd rights reserved
accurate age onset aoo measurement vital etiologic preventive research aoo reports known subject recall error population based studies used investigate agreement aoo reports decade examined aoo reports depression back neck pain daily smoking population based cohort spanning years stratified sample participants zurich switzerland completed psychiatric physical health interview times ages males females used one way anova estimate intraclass correlations iccs weighted mixed models estimate mean change time test interactions sex clinical characteristics stratum specific iccs among reports depression back pain smoking average yearly increases aoo report wave first month diagnosis reported smoking estimated mixed models years confidence interval depression years back pain years smoking initial impairment frequency treatment associated differences average yearly change depression substantial variability aoo reports time systematic increase age degree increase may differ outcome outcomes participant clinical characteristics future studies identify predictors aoo report stability ultimately benefit etiologic preventive research published elsevier ltd
background since turn century several epidemic outbreaks poultry diseases caused tembusu virus tmuv although multiple mosquito poultry derived strains tmuv isolated data exist comparative study origin evolution dissemination methodology parallel virology used investigate phenotypes duck mosquito derived isolates tmuv molecular biology bioinformatics methods employed investigate genetic characteristics evolution tmuv principal findings plaque diameter duck derived isolates tmuv larger mosquito derived isolates cytopathic effect cpe mammalian cells occurred rapidly induced duck derived isolates mosquito derived isolates furthermore duck derived isolates required less time reach maximum titer exhibited higher viral titer findings suggested poultry derived tmuv isolates invasive greater expansion capability mosquito derived isolates mammalian cells variations amino acid loci tmuv gene sequence revealed two mutated amino acid loci strains isolated malaysia thailand chinese mainland compared prototypical strain virus furthermore tmuv isolates chinese mainland six common variations gene loci differed southeast asian strains phylogenetic analysis indicated tmuv exhibit species barrier avian species consisted two lineages southeast asian chinese mainland lineages molecular traceability studies revealed recent common evolutionary ancestor tmuv might appeared malaysia thailand shandong province china represent three main sources related tmuv spread conclusions current broad distribution tmuv strains southeast asia chinese mainland exhibited longer range diffusion larger scale propagation therefore addition china asian european countries linked asia used improved measures detect monitor tmuv related diseases prevent epidemics poultry elsevier rights reserved
objectives analyze general cognitive performance perceived health depression predictors subjective memory complaints smc contrasting effect sizes analyze relationship smc objective memory comparing test measures memory daily life classical test associated pairs iii examine different subgroups formed according mfe score might different behaviors regarding studied variables methods sample community dwelling people mean age without cognitive impairment consecutive non probabilistic recruitment assessment mini cognitive exam mce daily memory rivermead behavioural memory test rbmt paired associates learning pal geriatric depression scale gds nottingham health profile nhp dependent variable memory failures everyday questionnaire mfe results two different dimensions explain smc found one subjective mfe gds nhp objective rbmt pal mce first strongly associated smc smc predictors nhp gds rbmt pal order according effect size considering mfe scores subdivided sample three groups low medium higher scores low mfe group associated gds medium gds nph rbmt higher age well effect size every variable tended grow mfe score higher conclusion smc associated health profile depressive symptoms lesser degree memory overall cognitive performance people fewer smc associated depressive symptomatology smc associated depression poor health perception lower memory elsevier ireland ltd rights reserved
scholars hypothesized victimization elicits distinctive effects women pathways prison subsequent prison maladjustment researchers investigated gender differences relationship using nationally representative samples men women housed state prisons examine gender differences effects experiencing different types nonstranger victimization prior prison inmate maladjustment results indicate pre prison nonstranger victimization affects men women maladjustment similarly gender differencesspecifically effect physically assaulted nonstranger adult violent misconduct stronger among men effect child abuse men depressive symptoms findings suggest effects experiencing nonstranger victimization prior incarceration prison maladjustment may gender neutral gender specific based findings nonstranger victimization deemed important theories men maladjustment well theories women maladjustment
functional features lactobacillus plantarum hac hac isolated fermented korean kimchi studied regard fat mass immunometabolic biomarkers dysbiosis diet induced obesity dio murine model rhamnosus lgg served reference strain pbs treated group control administration plantarum hac resulted reduction mesenteric adipose depot conjunctive tissue closely associated gastrointestinal tract lipid oxidative gene expression upregulated compared control group metagenome analysis intestinal microbiota showed strains hac lgg influenced specific bacterial families lachnospiraceae ruminococcaceae rather phyla firmicutes bacteroidetes whole relative abundance lachnospiraceae phylum firmicutes significantly higher lab treated groups control comparing impact two lactobacillus strains microbial composition gut also suggests strain specific effects study emphasises need deeper studies functional specificity probiotic organism strain level alleviation obesity associated dysbiosis modulation gut microbiota appears associated indicator bacterial taxa family lachnospiraceae may provide insight mechanisms basic mode probiotic action obesity associated dysbiosis
varicocele associated reduced male reproductive potential advances biomolecular techniques possible better understand mechanisms involved testicular damage provoked varicocele current evidence suggests central role reactive oxygen species ros resultant oxidative stress pathogenesis varicocele associated male subfertility although mechanisms yet fully described likely multifactorial excessive ros associated sperm dna fragmentation may mediate clinical manifestation poor sperm function fertilization outcome related varicocele testing ros dna fragmentation potential provide additional diagnostic prognostic information compared conventional semen analysis may guide therapeutic management strategies individual patient
purpose assess changes various functional satisfaction measures older persons enrolled minnesota senior health options msho managed care program older persons eligible medicare medicaid design methods used two sets matched controls msho enrollees families matched controls living community nursing homes persons county eligible enroll enroll msho persons metropolitan areas msho available community sample used questionnaires measure functional status activities daily living pain unmet care needs satisfaction caregiver burden approximately years first survey surveyed respondents lived community time first survey nursing home residents used annual assessments calculate case mix compare changes functional levels time results significant differences change time msho sample two control groups area controls showed greater increases pain area controls showed less interference pain compared area controls msho clients showed greater increase homemaker use meals wheels outpatient rehabilitation compared area controls showed use meals wheels less help family household tasks differences satisfaction msho families showed significantly lower burden controls five items implications analyses show modest evidence benefit msho compared two control groups model represented msho appear generate substantial differences outcomes across function satisfaction caregiver burden
paper demonstrates rail rail operational amplifier amp ultra low power internet things iot sensor nodes suppress leakage current logic part finfet technology threshold voltage chosen realize rail rail operation small common mode voltage headroom stage chopper stabilized topology high pass filters multi path hybrid nested miller compensation push pull output stage introduced near amplifier also introduced second stage boost gain fabricated amp shows mhz gain bandwidth whole voltage range
despite high rates trauma related disorders among individuals early psychosis clinical practice guidelines treatment comorbid early psychosis trauma related disorders exist date indeed routine exclusion individuals past current psychosis participation trauma research practice limited accumulation research could support clinical practice guidelines preliminary research evidence suggests traditional evidence based treatments trauma related disorders safely effectively employed reduce symptoms posttraumatic stress chronic psychosis remains unclear whether treatments appropriate individuals early stages psychotic illness clinical experts representing early psychosis programs across states surveyed using expert consensus method forty nine clinical experts responded reached consensus expert consensus items related treatment comorbid early psychosis trauma related disorders conjoint family therapy individual therapy rated treatment approaches choice anxiety stress management psychoeducation rated treatment interventions choice addressing trauma symptoms psychotic symptoms addition case management rated treatment intervention choice addressing psychotic symptoms consensus reached expert consensus items regarding appropriateness parallel treatment approach exposure interventions addressing psychotic symptoms sensorimotor movement interventions addressing trauma symptoms areas expert consensus exists supported current research preliminary clinical practice guidelines treatment comorbid early psychosis trauma related disorders offered areas expert consensus exist recommendations future research offered results study intended serve launching point scientists practitioners interested advancing appropriate treatment high risk underserved individuals comorbid early psychosis trauma related disorders
pine tar end product pine wood carbonisation following distillation using extreme heat extensive literature search conducted back review pine tar used medicine years treat range skin conditions soothing antiseptic properties pine tar confused coal tar produced coal approximately hundred years pine tar thought exert effect reducing dna synthesis mitotic activity promotes return normal keratinisation addition pine tar shown antipruritic anti inflammatory antibacterial antifungal properties make pine tar suitable topical treatment eczema psoriasis seborrhoeic dermatitis dry itchy flaky inflamed skin conditions topical products available counter australia today contain pine tar come several different formulations used entire body including face modern day pine tar manufactured increased purity eliminate toxic phenol carcinogenic components concern past primary irritation uncommon conclusion long experience topical pine tar therapy worldwide usage together evidence presented review suggests pine tar effective treatment minimal safety risk
responding ross cheit witch hunt narrative article commentary chronicling emergence child sexual abuse social issue los angeles county based responses child sexual abuse los angeles county experienced one social worker mcmartin years discusses impact mcmartin case identification intervention child sexual abuse cases tracks evolution changes took place southern california offers insight rationale denial child sexual abuse continues day
increasing capabilities computer modeling simulation technology analysis options maximizing gains energy efficiency buildings realized efficiently cost effectively conducting building performance simulations allows analysis environmental impacts buildings economic vitality green building techniques commercial buildings consume nearly one fifth energy used united states costing billion year building envelope plays key role determining much energy required operation building individual thermal solar properties glazing shading systems provide information based static evaluations important assess efficiency systems whole assembly site specific conditions paper presents case study conducted using computer simulation tools evaluate environmental economic impacts using different types glazing sunshade systems overall performance office building florida case study results show early stage building performance studies using computer simulation tools help practitioners achieving goals reduced energy consumption increased indoor comfort economical manner american society civil engineers
dissociation common reaction subsequent childhood sexual abuse csa identified risk factor child psychopathology also evidence mentalization contributes resilience context abuse however stage little known regarding relationship mentalization dissociation respective contributions psychopathology aim study examine pathways csa depressive symptoms externalizing behaviour difficulties sexualized behaviour mentalization dissociation pathways examined sample mother child dyads including dyads children aged histories sexual abuse maternal mentalization assessed using parent development interview revised children mentalization assessed using child reflective functioning scale children completed child depression inventory parents completed child dissociative checklist child behavior checklist child sexual behavior inventory direct indirect paths csa child psychopathology via children mentalization dissociation examined using mplus distinct paths abuse psychopathology identified child mentalization partially mediated relationship csa depressive symptoms effects csa externalizing symptoms sexualized behaviour difficulties sequentially mediated mentalization dissociation
development sensor machine learning technologies progressed become increasingly important detect patterns probabilistic data streams paper focus complex event processing based pattern matching apply pattern matching probabilistic data streams numerous matches may detected time interval uncertainty data although existing methods distinguish matches may derive inappropriate results matches correspond real world event occurred time interval thus propose two grouping methods matches methods output groups indicate occurrence complex events given time intervals paper first describe definition groups based temporal overlap propose two grouping algorithms introducing notions complete overlap single overlap propose efficient approach calculating occurrence probabilities groups using deterministic finite automata generated query patterns finally empirically evaluate effectiveness methods applying real synthetic datasets
objective estimate asthma prevalence severity associated factors adolescents live low relative humidity environment methods cross sectional study adolescents aged years city petrolina located brazilian semiarid region answered international study asthma allergies childhood isaac questionnaire possible explanatory variables study gender family income mother education smokers household parental history asthma personal history allergic rhinitis atopic dermatitis physical activity level poisson regression analysis used assess association asthma explanatory variables results total adolescents participated study male prevalence active asthma severe asthma physician diagnosed asthma respectively adolescents asthma missed school days peers days year associated factors remained significant adjustment history asthma parents personal diagnosis allergic rhinitis atopic dermatitis conclusion asthma prevalence low humidity environment lower severe reported brazilian cities dry climate might hamper disease control may contributed higher school absenteeism observed association asthma allergic rhinitis atopic dermatitis welt history asthma parents suggests atopy important risk factor asthma population sociedade brasileira pediatria published elsevier editora ltda open access article license
user profiles collaborative filtering recommendation technique built based ratings given users set items eminent shortcoming technique sparsity problem problem refers low ratio rated items users total number available items hence quality recommendation affected researchers use implicit data solution sparsity problem decrease dependency technique user rating term common field aim research aggregate evidence state research practice implicit data applying systematic literature review slr method evidence based software engineering ebse ebse potential value synthesizing evidence make evidence available practitioners researchers providing best references appropriate software engineering solutions sparsity problem executed standard systematic literature review method using manual search prestigious databases studies finally included analyzing paper follows manifestation kitchenham slr guidelines describes great detail process selecting analyzing research papers paper first academic systematic literature review technique along implicit data user behaviors activities aggregate existing evidence synthesis best quality scientific studies research papers categorized eleven application fields movie shopping books social systems music others six data mining techniques dimensionality reduction association rule heuristic methods according review results neighborhood formation relevant aspect improved use user item preference matrix implicit feedback mechanism common domains commerce movie software applications
people read dominance trustworthiness competence faces politicians also perceive social qualities nonverbal cues transferred body movements politicians giving speech onto animated stick figures presented stimuli participants rating experiment analyses revealed single body postures maximal expansiveness strong predictors perceived dominance also stick figures producing expansive movements well great number movements throughout encoded sequences judged high dominance low trustworthiness second step divided sample speakers opposition parties speakers part government well male female speakers male speakers opposition rated higher dominance lower trustworthiness speakers groups conclusion people use simple cues make equally simple social categorizations moreover party status male politicians seems become visible body motion authors published elsevier ltd open access article license http creativecommons org licenses
laboratories interested autophagy use different imaging software managing analyzing heterogeneous parameters immunofluorescence experiments puncta quantification determination number size lysosomes one solution would software works user laptop workstation access image settings provide quick easy use analysis data thus designed implemented application called ifdotmeter run major operating systems programmed using java sun microsystems briefly ifdotmeter software created quantify variety biological hallmarks including mitochondrial morphology nuclear condensation program interface intuitive user friendly making useful users familiar computer handling setting previously defined parameters software automatically analyze large number images without supervision researcher analysis complete results stored spreadsheet using software high throughput cell image analysis offers researchers possibility performing comprehensive precise analysis high number images automated manner making routine task easier
background according international guidelines treatment inflammatory arthritis based shared decision patient rheumatologist furthermore patients inflammatory arthritis high need information want actively involved medical decision making facilitate shared decision making support patients choosing disease modifying anti rheumatic drugs dmards web based patient decision aid ptda developed study evaluated use appreciation effect ptda methods post test study historical comparison group conducted two year period patients diagnosed rheumatoid arthritis psoriatic arthritis ankylosing spondylitis deciding whether start different dmard invited participate first year patients received standard information comparison group second year patients referred ptda intervention group groups questionnaire sent four weeks consulting rheumatologist patient characteristics included sociodemographic health related preference related variables process measures use appraisal ptda intervention group primary outcome measure patients perceived role medical decision making secondary outcome measures comprised satisfaction decision making process decision beliefs medication adherence medication trust physician results received questionnaires comparison group intervention group ptda used patients intervention group patients used ptda highly appreciated perceived easy use helpful relative comparison group patients intervention group perceived active role medical decision making decisions line patients personal preferences outcomes showed significant difference two groups conclusion web based ptda highly appreciated perceived helpful decision making implementation ptda rheumatology practice associated significantly larger proportion patients perceiving active role medical decision making decisions line patients personal preferences ptda valuable aid improving patient participation decision making dmards
among computer science courses intended high school non majors visual basic program design important foundation curriculum however traditional teaching acquiring programming theory knowledge especially difficult non computer major students urgent find effective way cultivate solid theoretical foundation strong practical ability students university computer teaching problem based learning novel teaching method based guidance construct theory good teaching effects many cases paper presented brief introduction pbl teaching method proposed novel instruction design method computer programming course teaching extra high teaching effects obtained practical application program design course demonstrated effectiveness proposed instruction design method problem based learning
purpose article describes protocol randomized effectiveness trial method link alcohol use disordered women pretrial jail detention post release step mutual help groups background jails serve times people per year prisons short stays posing opportunities treatment treatment planning alcohol use associated poor post jail psychosocial health outcomes including sexually transmitted diseases hiv especially women least weekly step self help group attendance months release jail associated improvements alcohol use alcohol related consequences linkage strategies improve step attendance alcohol outcomes among outpatients previously tested criminal justice populations design intervention condition step volunteer meets individually incarcerated woman jail arranges contact release accompany step meetings control condition provides schedules local step meetings outcomes include percent days abstinent alcohol primary step meeting involvement fewer unprotected sexual occasions secondary release jail hypothesize minton step involvement mediate intervention effect alcohol use brien percent days abstinent mediate intervention effect sti hiv risk taking outcomes research methods accommodate logistical philosophical hurdles including rapid turnover commitments unpredictable release times jail possible post randomization ineligibility due sentencing step principles nonaffiliation use volunteers interventionists elsevier inc rights reserved
attractiveness magnesium alloys structural applications caused intrinsic properties low density high specific strength main challenge development magnesium alloys connected requirement fulfill main function structural materials bear load wrought magnesium alloys possess strong basal texture causes anisotropy mechanical properties would interesting find way benefit anisotropic behavior magnesium alloys one way take account strong basal texture twinning magnesium alloys compressive deformation parallelepiped samples magnesium alloy successively deformed compression strain along two perpendicular directions first compression sample contracts along direction parallel compression axis elongates one perpendicular direction deformation observed third perpendicular direction subsequent compression along direction recovers initial shape sample microstructure analyses shows twinning main deformation mode compression along direction twin variants gives strain direction predominant microstructure twinfree microstructure observed subsequent compression along direction crystallographic analyzes calculations explain reversible motion twin boundaries favorable nucleation twin variants matrix grains compression along direction experiment presented article profile wrought magnesium alloy smart material emphasize importance strong texture twinning obtaining properties characteristic smart materials presented case ability produce recover significant strains controlled manner compressive stress elsevier ltd rights reserved
fiber laser used fiber optic communications laser cutting industrial manufacture defense security many fields advantages narrow output linewidth good reproducibility etc however due nonlinear thermal effects limited output power single fiber obtained sharp attenuation output beam quality obstructs applications fiber lasers therefore research expanding power fiber laser source maintaining beam quality combining coherent beam become hot subject present field performance phase control coherent laser beams key factor influence efficiency combination phase controlling methods mainly include stochastic parallel gradient descent control algorithm dithering heterodyne detection paper based active phase lock technology traditional heterodyne detection method improved use fiber electro optic phase modulator eom rather acousto optic frequency shifter aofs avoid complex designs driver circuit makes overall experimental setup simple stable moreover order achieve stable wide correction range phase locking two servo paths designed use piezoelectric transducer pzt eom correct optical phase differences firstly single frequency narrow width fiber laser central wavelength split beam splitter generate signal reference beam respectively reference beam phase modulated another eom mhz signal phase error signal obtained demodulating detected heterodyne signal modulation frequency error signal divided two parts sent two pid servos control pzt eom respectively pzt used slow feedback loop eliminates laser phase error induced ambient temperature drift eom quick feedback loop eliminate influence high frequency noise two pid servos carefully designed according measurements dynamic response pzt eom stable feedback loop bandwidth khz limited bandwidth pid controller obtained according measurement phase error signal spectrum thus tight lock expected consequence error phase locking less degrees indicates phase control accuracy lambda long term stability system assessed hour monitoring lock error signal according analysis allan deviation best phase lock value degrees obtained integration time overall phase lock experimental setup simple easy operate moreover phase lock improved optimizing parameters pid controller
haze removal useful computational photography computer vision applications although many haze removal algorithms proposed computational efficiency requires improvement real time haze removal method presented paper method based concept dark channel prior enhance haze removal performance approximate method estimate atmospheric light transmission employed embedded system applications hardware architecture perform real time haze removal proposed hardware achieve mhz stratix fpga simulation results indicate hardware highly efficient performs well obtains good image recovery results satisfies real time requirement even large images
consumption media violence aggressive behavior assessed three times sample german adolescents without migration background period two years month intervals adolescents two groups grades matched gender age type school academic achievement students migrant group reported higher consumption violent media showed physical less relational aggression peers german background cross lagged panel analyses showed parallel associations media violence use aggression groups media violence consumption predicted physical aggression independent ethnic background reverse path physical aggression media violence consumption nonsignificant link found media violence use relational aggression time
transition university stressful successful adjustment imperative well historically research transitional stress focussed negative outcomes ill health first study applying positive psychology approach investigate characteristics facilitate adjustment among new university students range psychological strengths conceptualised covitality factors shown individually influence stress subjective well swb relationship assessed among first year undergraduates week three first semester months later path analyses revealed optimism mediated relationship stress negative affect component swb time academic self efficacy demonstrated significant relationships life satisfaction positive affect contrary predictions stress levels remained stable time although academic alienation increased self efficacy decreased optimism emerged key factor new students adjust university helping buffer impact stress well throughout academic year incorporating stress management psycho educational interventions develop strengths discussed way promoting confidence agency new students help cope better stress university
background cells newly discovered helper cell subtype characterized high interleukin secretion growing evidences suggest cells involved pathogenic mechanism multiple sclerosis mast cells multifunctional innate immune cells perhaps best known role dominant effector cells allergies asthma several lines evidence point important role mast cells animal models simultaneously dynamic cross talk mast cells aim present study examine mast cell axis experimental autoimmune encephalomyelitis eae determine interaction neutralizing anti antibody treatment methods female cbl mice randomly divided three groups group mice myelin oligodendrocyte glycoprotein mog induced eae eae group eae mice treated anti antibody anti abs group eae mice treated igg isotype control igg group eae clinical score evaluated mast cells central nervous system cns detected flow cytometry production chemokine recruiting mast cells cns explored reverse transcription polymerase chain reaction pcr mice mog induced eae expression receptor complexes cns spleen mast cells also explored pcr repeating validated immunocytochemistry vitro spleen cells eae mice cultured anti antibody quantity mast cells counted flow cytometry culture results compared igg group blockade delayed clinical disease onset ameliorated eae severity accompany mast cells infiltration decreases day day day anti abs group messenger rna expressions motif chemokine ligand vascular cell adhesion molecule significantly decreased neutralization anti abs group compared igg group mog induced eae complexes expressed cns spleen mast cells vitro splenocytes cultured anti antibody showed significantly lower levels mast cells dose dependent manner compared splenocytes cultured anti mouse igg conclusions study revealed neutralization reduced mast cell infiltration cns ameliorated eae might relate interaction mast cells
paper presents effects output voltage current total harmonic distortion thd response increasing arm inductance smooth reactor hvdc modular multilevel converter mmc behavior based closed loop needless pid controller control also presents effects mmc quantities circulating current ripple maximum output voltage submodule capacitor ripple responses increasing value arm inductance increasing arm inductor size could reduce thd circulating current ripple waveforms mmc effect investigated paper closed loop needless pid controller control presented first second examination effect changing arm inductor mmc behavior carried based many simulation results paper order analyze change thd mmc quantities including circulating current upper arm current voltage lower arm current voltage output voltage current third arm inductance relationships output voltage current thd shown also arm inductance relationships circulating current ripple submodule capacitor ripple presented part study relationship arm inductance maximum output voltage explained finally hardware design software design prototype presented verify arm inductor value effect mmc experimentally experimental results also documented paper elsevier rights reserved
split cycle engine new reciprocating internal combustion engine potential radical efficiency improvement engine compression combustion expansion processes occur different cylinders compression cylinder charge air compressed quasi isothermal process direct cooling air high pressure air heated recuperator using waste heat exhaust gas induction combustion cylinder combustion process occurs expansion stroke quasi isobaric process paper fundamental theoretical cycle analysis one dimensional engine simulation split cycle engine undertaken results show thermal efficiency eta mainly decided compression ratio expansion ratio regeneration effectiveness sigma temperature rising ratio based analysis system optimization engine conducted results showed increasing combustion recuperation processes could improved increasing expansion ratio heat losses gas exchange stroke reduced furthermore coolant temperatures compression expansion chambers controlled separately reduce wall heat transfer losses compared conventional engine total efficiency improvement achieved split cycle applied concluded system optimization total thermal efficiency achieved split cycle engine elsevier ltd rights reserved
work presents development kit simulate behavior load flow voltage stability power system network designed implemented useful tool engineering studies laboratory practices also measurement steady state compared digital behavior simulation using power world software system configuration extracted one similar typical network used literature power systems basically infinity bus two generators loads six transmission lines permit also synchronization tests making digital analog measurements generators loads constant impedance resistors capacitors reactors infinity bus belong lab volt commercial brand transmission short line models designed using easy acquisition materials addition use digital instrument aemc series permits capture information
puting forward idea sustainable development urban landscape design reduce huge pressure urban environment suffers get ecological social economic multiple benefits exploring design principles methods sustainable landscape land use landscape materials engineering technology ecological system maintenance management landscape aspects providing reference healthy development cities urban landscape
need reducing pollution congestion energy consumption increasing interest light electric vehicles bikes play important role scenario since cost effective easy use small footprint paper explores series hybrid electric bicycle concept vehicle characterized absence mechanical transmission pedals connected generator electrically coupled battery pack electric motor increases degrees freedom assistance provided poses several challenges human interfacing energy management proposed vehicle equipped throttle pedals time power source human machine interface paramount vehicle controlled yield natural feeling pedaling dynamics level vehicle level paper obtained bilateral control framework paper discusses design control system along several considerations choice generator motor tuning controller finally extensively experimentally analyzed human loop setting considering cycling feeling energy flows
methane reforming carried internal combustion engine engine reformer successfully produced syngas partial oxidation natural gas cylinder diesel engine reconfigured perform spark ignition performing reaction engine cylinder allows exothermicity captured useful work intake conditions kpa degrees allowed low cycle cycle variability covnimep methane air equivalence ratios phi producing syngas ratio spark ignition timing varied degrees top dead center btdc piston position showing significant improvement delayed timing hydrogen ethane added simulate recycle downstream synthesis reactor realistic natural gas compositions respectively adding gases yielded stable combustion hydrocarbon air equivalence ratios phi covnimep equivalence ratios results demonstrate engine reformer could key component compact gas liquids synthesis plant highlighting operating conditions high gas conversion high ratios close low soot production possible
popular trend sports characterized intensive high speed performance due high energy mechanism falls typical injury distributions patterns result retrospective study injury patterns frequencies mountain bike athletes analyzed pathophysiological diagnostic therapeutic options treatment high energy injuries carpal bones shown based retrospective survey successive years active mountain bike athletes world cup series interviewed using standardized questionnaire injury patterns frequencies analyzed pathophysiology diagnostics therapy high energy carpal injuries discussed study world cup mountain bike athletes enrolled injuries extremities found athletes higher prevalence upper extremities lower extremities followed injuries head face traumatic brain injuries trunk fractures dislocations hand wrist found approximately half athletes popular trend sports injuries extremities common especially carpal bones ligaments important distinguish stable destabilizing injuries order provide adequate therapeutic options
objective systematic review identify current computer assisted technologies used managing patients need establish craniofacial appearance subjective discomfort stomatognathic function extent clinical documentation electronic search strategies used locating clinical studies medline pubmed cochrane library grey literature searches google scholar searches commercial digital products use oral rehabilitation resulted identifying products per november used patient diagnostics communication therapy purposes computer assisted applications context oral rehabilitation one third products described papers reporting clinical human studies great majority digital products use oral rehabilitation clinical documentation products distinct minority manufacturers frequently appeared less scientific reports moore law apply also digital dentistry predicts capacity microprocessors continue become faster lower cost per performance unit innovative software programs harness improvements performance net effect noticeable short product life cycle digital products developed use oral rehabilitation often lack supportive clinical documentation nonetheless clinicians must request clinically meaningful information new digital products assess net benefits patients dental professionals accept technological verbiage basis product purchases
forward reservoir simulation frs challenging process models fluid flow mass transfer porous media draw conclusions behavior certain flow variables well responses besides operational cost associated matrix assembly frs repeatedly solves huge computationally expensive sparse ill conditioned unsymmetrical linear system moreover computation practical reservoir dimensions lasts long times speeding process taking advantage parallel platforms indispensable considering state art advances massively parallel computing accompanying parallel architecture work aims primarily developing coda based parallel simulator oil reservoir addition initial reported times speed gain compared serial version running experiments showed bicgstab stable fast solver could incorporated simulations instead expensive storage demanding usually utilized gmres elsevier rights reserved
water hydraulic variable ballast system whvbs competitive mechanism realize hovering system one popular ways expand maneuvering capability auvs however whvbss equipped auvs almost type without controlling flow rate ballast water limits hovering performance auvs operated complex underwater environment paper three novel types whvbs supports one two low cost means control flow rate ballast water proposed improve performance auv hovering system torpedo like auv equipped whvbs used simulation platform verify effectiveness proposed whvbss numerical simulation results support idea compared commonly used type whvbs whvbss introduced flow rate control significantly improve hovering performance auv especially situations unfavorable sea wave disturbances additionally statistics water usage different whvbss numerical simulation indicated novel whvbss potential extend mission duration auv elsevier ltd rights reserved
within policies organization possible find allow users access sites internet entertainment social networks case production organizations educational therefore firewall used implemented certain rules based policies organization blocks access certain defined sites let others free however implemented rules block proxies avoidance internet censorship systems user access easily proxies addresses proxies change frequently almost impossible block eventually appear proposed solution create firewall uses dynamic rules rules created dynamic firewall test address destination made finds destination proxy one evation systems firewall creates new rule automatically implemented way user lose access proxy
beta gamma coincidence counting system kriss korea research institute standards science operated analog signal processing mode develop implement digital sampling method using commercially available analog digital converter implementation digitize amplified pulse trains generated three detector channels determine locations amplitudes peaks using peak detection algorithm develop offline analysis routines process recorded locations amplitudes activity determinations means efficiency extrapolation method activity determinations make corrections effects channel events correlation data points validate digital sampling method measuring activity comparing measurement results obtained analog mode digital method capable facilitating activity standardization radionuclides short half lives elsevier rights reserved
energy audit one department faculty engineering technology university jordan conducted way apply concept green building existing structure according jordanian green building code classification green building carried according saving energy water addition factors indoor quality material heating cooling loads calculated results compared values building amendments windows walls insulation external walls building introduced addition double glazing instead current single glass windows building electricity lighting consumption building obtained analyzed potential utilizing lighting sensor different halls rooms studied analyzed boiler performance studied estimation efficiency enhancement proposed found choosing larger window area facing south east west save energy winter decreasing heating costs using certain types double glazing decreasing glazing area facing north save money energy also found payback period annual saving fuel electricity bills less years needed investment obtaining energy saving shown paper published elsevier ltd
attachment anxiety parents associated lower quality parent child relationships inhibited capacity reflect children mental states referred prementalizing may reduce pleasure parents derive relationships current study explored associations among attachment anxiety prementalizing parenting satisfaction two groups participants randomly assigned either reflect positive memory child reflect positive memory involving child narratives evaluated positive content using two metrics coder rated positivity frequency positive emotion words results revealed selfreported prementalizing operated indirectly link attachment anxiety self reported parenting satisfaction groups however prementalizing served indirect link attachment anxiety coded measures positivity among participants reflected parenting experiences suggesting specificity prementalizing linking attachment anxiety reduced positivity parenting role results implications understanding influences attachment mentalization parents perception parent child relationship quality
micrornas mirnas large family small highly conserved non coding rnas regulate gene expression translational repression mrna degradation aberrant expression mirnas underlies spectrum diseases including organ fibrosis recent evidence suggests mirnas contribute organ fibrosis mediating epithelial mesenchymal transition emt alleviation emt proposed promising strategy fibrotic diseases given key role emt fibrosis mirnas impact expression specific ligands receptors signaling pathways thus modulating emt consequently influencing fibrosis review summarizes current knowledge concerning mirnas regulate emt highlights specific roles mirnas regulated emt plays fibrotic diseases diverse pulmonary fibrosis hepatic fibrosis renal fibrosis cardiac fibrosis desirable comprehensive understanding functions mirnas regulated emt facilitate development novel diagnostic therapeutic strategies various debilitating organ fibrosis
recent years aircraft production especially assembly large structural components always compared crafted shipyard labor highly productive automotive line paper describes lean concepts helping embraer bring new paradigms stage applying fundaments new wing assembly line evora portugal starting design manufacturing principles product full application production preparation process concept line early design planning going designed automation assembly tooling intense application manufacturing simulation tools like ergonomic analysis dimensional management well state art digital manufacturing execution systems shop floor management embraer intends create highly efficient work flow developments ultimately ensure product quality continuous stable production rates highly efficient use available resources
due limited cognitive communicative abilities adults intellectual disabilities current treatment options depression often limited lifestyle changes pharmacological treatment bright light therapy blt effective intervention seasonal non seasonal depression general population blt inexpensive easy carry intervention minimal side effects however knowledge anti depressant effect adults lacking obstacles realizing controlled intervention study particular study population may contributed lack study effect blt depression population necessary successfully execute multicenter randomized controlled trial rct therefore study protocol management anticipated obstacles regarding trial presented elsevier ltd rights reserved
background schizophrenia patients respond clozapine treatment represent debilitating type schizophrenia unmet needs novel interventions date validated animal model clozapine refractory schizophrenia methods used poor performance social preference test mice exposed sub chronic phencyclidine pcp correlate negative signs schizophrenia subsequently mice treated clozapine according defined responding clozapine pcp ratio non responsive clozapine generation responding mice mated produce next generation unfortunately clozapine non responsive mice failed proliferate thus excluded analyses forward genetic paradigm used produce next generation clozapine responding mice assessed brain glutamic acid decarboxylase gad protein levels gaba ergic marker generations results already generation male mice females possible discriminate clozapine responders non responders rate responders within consecutive generation increased increase pronounced females regulation gad levels detected male clozapine responder mice females conclusions preliminary proof concept study succeeded producing trans generation enrichment clozapine responsiveness trait hypo glutamatergic animal model negative signs schizophrenia model may serve platform better characterize clozapine responsiveness trait offer model clozapine responsive schizophrenia elsevier rights reserved
present new approach model predictive control mpc oriented experiment design identification systems operating closed loop method considers design experiment minimizing experimental cost subject probabilistic bounds input output signals due physical limitations actuators quality constraints identified model excitation done intentionally adding disturbance loop design external excitation achieve minimum experimental effort also taking care tracking performance mpc stability closed loop system guaranteed employing robust mpc experiment problem defined optimization problem however aforementioned constraints result non convex optimization relaxed using results graph theory proposed technique evaluated numerical example showing attractive alternative closed loop experiment design elsevier ltd rights reserved
resistance distance two vertices connected graph defined effective resistance electrical network constructed replacing edge unit resistor kirchhoff index graph defined sum resistance distances pairs vertices denote specified class graphs vertices obtained identifying vertex complete graph root tree respectively obtain ordering relations kirchhoff indices four graph transformations thus determine graphs first smallest fifth smallest kirchhoff indices well maximal kirchhoff index respectively
purpose automated segmentation breast fibroglandular tissue fgt required various computer aided applications breast mri traditional image analysis computer vision techniques atlas template matching edge surface detection applied solve task however applicability methods usually limited characteristics images used study datasets breast mri varies respect different mri protocols used addition variability breast shapes variability addition various mri artifacts makes challenging task develop robust breast fgt segmentation method using traditional approaches therefore study investigated use deep learning approach known net materials methods used dataset breast mri randomly selected scientific archive includes five different mri acquisition protocols breasts four breast density categories balanced distribution prepare reference segmentations manually segmented breast fgt images using house developed workstation experimented application net two different ways breast fgt segmentation first method following pipeline used traditional approaches trained two consecutive nets first segmenting breast whole mri volume second segmenting fgt inside segmented breast second method used single class net performs tasks simultaneously segmenting volume three regions nonbreast fat inside breast fgt inside breast comparison applied two existing published methods dataset atlas based method sheetness based method used dice similarity coefficient dsc measure performances automated methods respect manual segmentations additionally computed pearson correlation breast density values computed based manual automated segmentations results average dsc values breast segmentation obtained net nets atlas based method sheetness based method respectively average dsc values fgt segmentation obtained net nets atlas based methods respectively correlation breast density values based net manual segmentations value significantly higher obtained nets steiger test bonferoni correction obtained atlas based method conclusions conclusion applied deep learning method net segmenting breast fgt mri dataset includes variety mri protocols breast densities results showed net based methods significantly outperformed existing algorithms resulted significantly accurate breast density computation american association physicists medicine
contribution efficient multiscale computational formulation developed geometric nonlinear analysis heterogeneous piezoelectric materials formulation relations microscopic heterogeneous properties macroscopic behaviors piezoelectric composite established numerically constructed displacement electric potential base functions heterogeneous complex microstructure equivalent simple macroscopic piezoelectric coarse element constructed multiscale base functions equivalent tangent stiffness matrix internal force vector macroscopic coarse element deduced based rotational approach describe motion macroscopic coarse element clearly efficiently thus original electro mechanical coupling geometric nonlinear problem could solved iteratively macroscopic scale save tremendous amount computing time cost macroscopic calculations microscopic mechanical electrical responses could retrieved calculated macroscopic solutions using mentioned multiscale shape functions verify validation high efficiency proposed multiscale computation formulation several typical numerical examples carried computation results indicate developed multiscale formulation could provide high precision solutions also high efficiency elsevier ltd rights reserved
present study examined gills liver histopathology freshwater fish chub caught three different sites site askale site dumlu site serceme karasu river site concentrations metals cadmium aluminum arsenic lead manganese exceeded acceptable levels according turkish standards institute moreover concentrations metals liver gills collected fish determined presence histological alterations assessed degree tissue change quantitative histological assessment indicated histological lesions comparatively severe liver results revealed anthropogenic pollution aquatic ecosystems affected fish natural habitat
chemicals ubiquitous food eat water drink air breathe products use work personal lives toxic chemicals increase risk cognitive behavioral neurodevelopmental disorders throughout life span toxic substances control act intended allow collection data regulation chemicals criticized significant limitations protecting public health recognition scientific evidence demonstrating connection toxic environmental chemicals neurodevelopmental disorders project tendr targeting environmental neuro developmental risks collaborative initiative scientists health professionals children health advocates produced call action last july aim reducing exposure chemicals pollutants contribute development disorders
dabigatran oral direct thrombin inhibitor approved international regulatory agencies stroke prevention patients paroxysmal persistent non rheumatic atrial fibrillation benefits dabigatran widely described use geriatric population without risk chronic kidney disease common comorbidity thus frequent checks renal function elderly patients recommended report case dabigatran intoxication elderly man affected heart failure worsening renal function developed acute hepatitis coma successfully treated continuous veno venous hemodiafiltration although extracorporeal therapy suggested strategy clearing dabigatran acute bleeding approach may useful dabigatran related life threatening conditions described report
health maintenance depends preservation homeostatic systems nervous endocrine immune system proper communication regard circadian system promotes better physiological system functions thus well could considered part homeostatic complex since neuroimmunoendocrine system possesses circadian patterns variables well circannual seasonal variations aging impairment homeostatic systems occurs alteration circadian system regulation demonstrated immune system several function parameters good markers health rate aging change age immunosenescence also throughout day year indeed advancing age modification immune cell circadian function especially lymphocytes moreover immune functions early afternoon correspond aged values morning especially mature subjects years age addition mature men women showed significant impaired immune cell function especially remarkable winter noteworthy role immunomodulatory hormones melatonin regulation biological rhythms involvement aging process furthermore evidence neuroimmune regulation circadian system disturbance aging highlights importance proinflammatory cytokines complex cross talk biological rhythms disruption age diseases jet lag cancer seasonal affective disorder could contribute increasing immune system impairment consequently loss health
gangweigou floodway across quiren rende districts tainan taiwan designed bypass partial discharge gangweigou river heavy rainfall events purpose flood control flood way excavated open channel supported single double rows precast cantilever pile walls side banks piles installed jetting assisted method twenty days completion floodway put work first time heavy rainfall unexpectedly cantilever pile walls several sections failed caused collapse slope behind walls paper explores failure mechanism real causes failure case based conditions hydrology hydraulics failure processes results stability analyses concluded ignoring possible bed incision bank erosion likely primary problem improper design critical condition water level floodway quickly dropped resulted rapid drawdown failure case could avoided rapid drawdown condition potential channel bed incision considered elsevier rights reserved
investigate suppression vibrations wind turbine tower using colocated feedback achieve strong stability decompose system one model describing vibrations plane turbine axis another model plane turbine blades plane turbine axis obtain non uniform spacecraft control laboratory experiment scole model either force control torque control show system strongly stabilizable static output feedback either velocity angular velocity nacelle plane turbine blades model wind turbine tower non uniform scole system coupled two mass drive train model control torque created electrical generator prove generically system strongly stabilized feedback angular velocity nacelle angular velocity generator rotor
mpj express messaging system allows application developers parallelize compute intensive sequential java codes high performance computing clusters multicore processors paper extend mpj express software provide two new communication devices first device called hybrid enables mpj express exploit hybrid parallelism cluster multicore processors sitting top existing shared memory network communication devices second device called native uses jni wrappers interfacing mpj express native mpi implementations like mpich open mpi evaluate performance devices range interconnects including ethernet myrinet infiniband addition analyze evaluate cost mpj express buffering layer compare performance numbers java mpi libraries performance evaluation reveals native device allows mpj express achieve comparable performance native mpi libraries latency bandwidth point point collective communications significant gain performance compared existing communication devices hybrid communication device without modifications application level also helps parallel applications achieve better speedups scalability exploiting multicore architecture performance evaluation quantifies cost incurred buffering impact overall performance software witnessed comparative performance new devices improve application performance achieve upto theoretical bandwidth available without application rewriting effort including nas parallel benchmarks point point collective communication
novel generalized pattern search gps based cellular automata gps model developed simulate urban land use change gis environment model built fitness function computes difference observed results produced remote sensing images simulated results produced general model gps optimization incorporating genetic algorithms gas searches minimum difference smallest accumulated residuals fitting transition rules coefficients captured gps method clear physical meanings closely associated dynamic mechanisms land use change gps model applied simulate urban land use change kunshan city yangtze river delta results show gps method smaller root mean squared error logistic regression method fitting transition rules gps model thus outperformed model overall accuracy improvement result gps model superior tool modeling land use change well predicting future scenarios response different conditions support sustainable urban development
background although individuals experience successful weight loss following roux gastric bypass rygb weight regain concern composition well documented aim evaluate changes body composition handgrip strength measure functional status participants previous year post rygb longitudinal study undergone rygb approximately years prior methods five women original larger cohort monitored pre rygb months months year years post rygb body composition assessed time points using dual energy ray absorptiometry multiple dilution handgrip strength measured using digital isokinetic hand dynamometer takei scientific instruments ltd tokyo japan results mean time final follow years lean soft tissue lst loss similar year period average compared year post rygb year lst lower fat free mass decreased year period mean fat mass decreased pre rygb year post rygb trended toward increase year years post rygb loss lst correlated loss handgrip strength conclusion continued loss lean mass associated decreased handgrip strength occurring long term trend toward regain post rygb concerning loss lst functional strength carries particular implications aging bariatric population investigated
article examines experiences family caregivers working patients affected overactive bladder oab hong kong chronic diseases create physical emotional burdens patients also family caregivers often experience physical emotional burnout social impairment extensive literature pertained caregiver experiences western non western settings however studies addressed livelihoods experiences family caregivers patients oab ethnic chinese communities increasing prevalence oab worldwide study investigated experiences caregivers hong kong examining emotional social needs qualitative research design individual semistructured interviews adopted snowball sampling used recruit family caregivers referred patients oab participants interviewed individually may august phenomenological approach adopted data analysis data revealed participants unpleasant experiences caring family members oab sense powerlessness helplessness confusion guilt well grievances social withdrawal prevalent causing great physical emotional suffering subsequent physical emotional burnout negative experiences often caused confusion regarding caretaking duties negative emotions participants family members also caused lack communication mutual understanding disease causing care giving even confusing difficult furthermore traditional chinese cultural values gender expectations male participants experienced triple burden employment domestic duties care giving holistic social healthcare support services provided care giving family members patients oab patients empowering caregivers attend family members care emotional well
existing adaptive educational hypermedia systems using learning resources sequencing approaches order enrich learning experience context educational resources either expository evaluative play central role however lack tools support sequencing essentially due fact existing specifications complex paper presents seqins sequencing tool digital educational resources seqins includes simple flexible sequencing model foster heterogeneous students learn different rhythms tool communicates ims learning tools interoperability specification plethora learning systems learning management systems repositories authoring automatic evaluation systems order validate seqins integrate learning ensemble framework instance computer programming learning domain
novel method approximating fractional order systems presented vector fitting involved method basis approximation fractional order systems approximation fractional order operators mostly achieved curve fitting frequency domain well known oustaloup method however methods several serious defects principle new perspective based system identification adopted deal approximation fractional order operators paper moreover nonzero initial condition approximating fractional order systems considered proposed assignment initial values caputo case offers effective solution simulation nonzero initial condition finally numerical examples given verify efficiency proposed method
dismissed innocuous experience childhood bullying recognized significant psychological effects particularly chronic exposure victims bullying risk number psychiatric disturbances growing evidence suggests pathophysiological effects bullying forms trauma chronic stress create additional health risks review literature known sequelae bullying including psychiatric physiological health effects focus implications victim addition since well established early chronic exposure stress significant negative impact health outcomes explore implications research relation bullying victimization childhood particular examine aspects stress response via epigenetic inflammatory metabolic mediators capacity compromise mental physical health increase risk disease research relevant mechanisms associated bullying potential interventions decrease morbidity urgently needed
background neutralizing autoantibodies nabs plasma serpin inhibitor inh implicated rare disorder acquired angioedema insufficient understanding process antibody formation correlation disease progression severity developed elisa detecting neutralizing capacity anti inh positive plasma samples used study changes nab repertoire patient plasma course disease methods eusa based specific interaction active inh target protease decrease amount bound immobilized inh presence test samples proportional neutralizing capacity sample assay specificity intra inter assay variation assay cut determined using anti inh antibodies assay capability demonstrated using plasma samples aae patients results assay specific neutralizing anti inh antibody shows interference non neutralizing anti inh antibody plasma matrix intra assay inter assay variations determined respectively neutralizing capacity antibody positive patient plasma samples igg igm type antibodies readily determined samples show positive neutralizing capacity conclusion developed robust specific semi quantitative assay detect neutralizing capacity plasma samples containing anti inh antibodies assay important tool study clinical implications anti inh nabs elsevier rights reserved
polymorphism opioid receptor gene oprm investigated role sensitivity social contexts evidence suggests allele polymorphism associated higher levels sensitivity study tested main effects polymorphism interaction self report measure childhood adversity index negative environment outcomes several personality measures relevant social connection significant interactions obtained negative impact childhood adversity personality greater among carriers among homozygotes measures agreeableness interdependence anger proneness hostility authentic pride life engagement index mostly negative feelings coloring one world view findings support role oprm sensitivity negative environments limitations noted including lack measure advantageous social environment assess sensitivity positive social contexts
purpose evaluate association internet addiction aggressive behaviors well moderating effects gender school depression association evaluate association internet activities aggressive behaviors methods total adolescents recruited study completed questionnaires aggressive behaviors without internet addiction internet activities demographic data without depression self esteem family function watching violent assessed results results demonstrated controlling effects shared associated factors watching violent programs adolescents internet addiction likely aggressive behaviors previous year association significant among adolescents junior high schools senior high vocational schools online chatting adult sex web viewing online gaming online gambling bulletin board system associated aggressive behaviors conclusions results suggest preventive programs aggressive behaviors pay attention internet addiction among adolescents also intervention prevent effects internet addiction aggressive behaviors conducted early possible society adolescent medicine rights reserved
paper deals novel quasi oppositional harmony search algorithm qohsa based design load frequency controller autonomous hybrid power system model hpsm consisting multiple power generating units energy storage units qohsa novel improved version music inspired harmony search algorithm obtaining best solution vectors faster convergence rate paper efficacy proposed qohsa adjudged optimized load frequency control lfc autonomous hpsm studied hpsm consists renewable non renewable energy based generating units wind turbine generator solar photovoltaic solar thermal power generator diesel engine generator fuel cell aqua electrolyzer energy storage units consists battery energy storage system flywheel energy storage system ultra capacitor gains conventional controllers integral controller proportional integral controller proportional integral derivative pid controller installed frequency controller one time proposed hpsm optimized using qohsa mitigate frequency deviation owing sudden generation load change order corroborate efficacy qohsa performance qohsa design optimal lfc compared well established technique teaching learning based optimization algorithm tlboa comparative performances hpsm action qohsa tlboa based optimized conventional controllers pid investigated compared present work found qohsa tuned frequency controllers improves overall dynamic response terms settling time overshoot undershoot profile frequency deviation power deviation studied hpsm elsevier ltd rights reserved
order improve prediction ability welding quality high power disk laser welding new approach proposed applied classification dynamic features metal vapor plume six features extracted color image processing method three features including area plume number spatters horizontal coordinate plume centroid selected based classification accuracy rates pearson product moment correlation coefficients support vector machine model adopted classify welding quality status two categories good poor results demonstrated support vector machine model established according selected features satisfactory prediction generalization ability classification accuracy rate higher model could applied prediction welding quality high power disk laser welding
retinal hemosiderin deposition histologic indicator sustained hemorrhage used precisely estimate elapsed time since episode trauma month old male infant admitted hospital acute deterioration examination revealed encephalopathy subdural hematomas retinal hemorrhages consistent abusive head trauma aht age readmitted hospital spontaneous osteopenic fracture right femur patient deteriorated died unsuccessful resuscitation ophthalmopathological investigation showed atrophy retina optic nerve hemosiderin deposition eyes retinal hemosiderin deposition currently generally assumed disappear within weeks occurrence hemorrhage aht case report describes infant bilateral retinal hemosiderin depositions due hemorrhages sustained aht occurring months prior death implications finding interpretation retinal hemosiderin depositions aht discussed
nodulus caroticus carotid body structure located carotid bifurcation carotid body tumour common tumour among paragangliomas chemodectomas even though incidence less tumours nodulus caroticus tumor arise every age although majority patients years old moreover related gender tumors benign percentage malignity less symptoms also express long time patient may report headache presence lateral neck mass dizziness hearing loss tinnitus dysphagia hoarseness syncope bernard horner syndrome transient blindness report complex clinical case patient may report headache presence lateral neck mass dizziness earring loss tinnitus dysphagia hoarseness syncope bernard horner syndrome transient blindness
cross sectional study examined relationship headache specific locus control hslc migraine related quality life anxiety mediator relationship two hundred thirty two people migraine participated treatment severe migraine trial baseline participants completed self report questionnaires headache specific locus control hslc subscales internal chance medical professionals anxiety migraine related quality life correlations examined relationships hslc anxiety migraine related quality life ordinary least squares regression evaluated anxiety mediator relationship hslc migraine related quality life higher internal hslc related higher overall migraine related quality life emotion function impairments anxiety mediated relationship internal hslc measures migraine specific quality life higher external medical professionals chance hslc related higher migraine related quality life impairments hslc beliefs associated higher migraine related quality life impairments anxiety mediates relationship internal hslc migraine related quality life
cpap continuous positive airway pressure therapy common therapy treat obstructive sleep apnoea syndrome upper respiratory tracts collapse may lead breathing interrupts sleep cpap device provides positive pressure splint airways influence pressure different patient patient medical condition shown many cpap devices maintain required pressure set points mask pressure seriously influenced patient breathing work electromechanic part pneumatic part breathing therapy system modeled provide opportunity model based control approach based physical chain effect existing control strategy extended end control results shown conclusion made
patients diagnosis schizophrenia display social cognitive deficits however little known patients nonverbal communication social encounters others review identified studies investigating nonverbal communication patients unscripted face face interactions addressing nonverbal differences patients others nonverbal behavior patients partners association nonverbal behavior symptoms association nonverbal behavior social outcomes patients displayed fewer nonverbal behaviors inviting interaction negative symptoms exacerbating pattern positive symptoms associated heightened nonverbal behavior patients partners changed nonverbal behavior response patient reduced prosocial behaviors inviting interaction associated poorer social outcomes evidence suggests patients nonverbal behavior face face interaction influenced patients symptoms impacts success social interactions
alzheimer disease common neurodegenerative disease imbalance production clearance amyloid beta beta peptides considered primary mechanism pathogenesis amyloid hypothesis supported recent success human anti amyloid antibody aducanumab clearing plaque slowing clinical impairment prodromal mild patients phase trial peptide combining polyarginines polyr charge repulsion segment derived core region beta amyloid sequence recognition designed efficacy designed peptide beta amyloid reduction improvement cognitive functions evaluated using app double transgenic mice daily intranasal administration pei conjugated beta peptide significantly reduced beta amyloid accumulation ameliorated memory deficits transgenic mice intranasal administration feasible route peptide delivery modular design combining polyr aggregate forming segments produced desirable therapeutic effect could easily adopted design therapeutic peptides proteinaceous aggregate associated diseases
introductionthis study aimed describe mental health status sulfur mustard exposed survivors suffering severe respiratory ophthalmological problems methodsout invited iran iraq war survivors sulfur mustard exposure severe symptoms participated cross sectional study mental health status assessed using diagnostic statistical manual mental disorders fourth edition criteria fisher exact test pearson chi square test chi square test used assess relationship independent sample test employed compare differences veterans ocular pulmonary injuries resultsthere survivors suffered mental disorders among previously untreated required initiation psychiatric treatment prevalence anxiety mood disorders among survivors respectively common anxiety mood disorders posttraumatic stress disorder major depressive disorder respectively psychiatric disorders prevalent cases severe pulmonary chemical injury subjects severe ophthalmologic chemical injury significant relationships found types psychiatric disorders age education occupation conclusionthe psychiatric morbidity chemically injured populations remarkable significantly different populations prevalence mental illness groups highlights need appropriate provision mental health services
safety management important part construction management building engineering dynamic work environment complicated construction procedure safety checking identifies hazards occur core process safety management construction sites however traditional construction safety checking operated experienced manager manual time consuming order integrate new technology construction safety checking system meta model construction safety checking cscontology construction safety checking ontology developed paper model formalized using ontology language owl encoding knowledge web safety checking constraints extract construction safety regulation provisions represented rule language swrl construction safety checking processes implemented jess rule engine java platform transforming owl knowledge jess facts swrl constraints jess rules real world example demonstrated protege beta show proposed safety checking process according regulation examples taken cfr osha construction industry regulations elsevier ltd rights reserved
persistent need sustainable energy economy led researchers focus novel energy conversion storage technologies inspiring discovery smart material designs hierarchical nanocomposites nanocomposites proven effective advancement energy based technologies synergistic properties hierarchical nanocomposites composed two types two dimensional layered materials layered double hydroxides graphene resulted improved electrochemical well photocatalytic performance synthetic strategies effect electrochemical photocatalytic performance nanocomposites high performance supercapacitors water oxidation catalysts discussed detail review
order promote english level undergraduate students universities western china classroom practice bilingual teaching professional course studied study water pollution control engineering pilot courses classroom practice bilingual teaching discussed bilingual teaching students grasp basic terminology vocabulary basic theory oral communication basic expertise basic terminology vocabulary engineering technology engineering design english writing basic expertise basic terminology vocabulary basic environmental protection equipment bilingual teaching results experience achieved used basis reference professional courses continue practice bilingual teaching classroom
high rate relapse drug use one main problems treatment addiction stress plays essential role drug abuse relapse nevertheless little known mechanisms underlying stress relapse accordingly effects intra accumbal administration sulpiride dopamine like receptor antagonist ineffective morphine dosefood deprivation morphine priming induced reinstatement conditioned place preference cpp adult male albino wistar rats weighing bilaterally implanted cannula nucleus accumbens nac subcutaneous injection morphine used daily day conditioning phase period following achievement extinction criterion rats tested priming induced reinstatement morphine cpp ineffective priming dose morphine respectively next experiments animals received different doses intra accumbal sulpiride saline bilaterally subsequently tested morphine reinstatement findings indicated facilitated reinstatement morphine cpp furthermore like receptor antagonist attenuated ineffective morphine dose priming induced reinstatement morphine cpp dose dependently also contribution like receptors mediation ineffective morphine dose induced reinstatement cpp greater morphine priming induced reinstatement cpp role dopaminergic system morphine reinstatement neural pathway nac provides evidence like receptor antagonist useful therapeutic targets reinstatement morphine cpp
objective given paucity research among prisoners study aimed examine prevalence psychiatric comorbidity associated adult adhd method study conducted four nsw correctional facilities male female results thirty five percent sample screened positive adult adhd sample met criteria full diagnosis adjustment benzodiazepine dependence borderline personality disorder social phobia antisocial personality disorder number lifetime psychological disorders remained significantly independently associated diagnosis adult adhd lowering threshold adhd self rating scale increased sensitivity lowered specificity conclusion adult adhd among nsw prisoners elevated substance use disorders psychiatric comorbidity common greater acceptance disorder among prisoners appropriate treatment warranted
paper find multiple travelling wave solutions using three integration schemes integrate model electrical transmission line schemes expansion method extended tanh method sine cosine method applied computerized symbolic computation different kinds solutions solitary shock singular periodic rational kink shaped obtained corresponding integrability criteria also known constraint conditions naturally emerge analysis transmission line equation
purpose purpose paper examine relationship major personality dimensions attitudes towards peace war design methodology approach three samples two consisting british psychology students one israeli students responded measures five factor inventory symlog trait form general survey including authoritarianism attitudes towards peace war specific attitudes towards peace war policy findings general attitude measures associated specific attitudes associated authoritarianism consistently personality dimensions research limitations implications descriptive findings might generalize need contextualization authoritarianism measured studies attitudes related peace war conflict structural violence practical implications practitioners peace education may first need address high authoritarianism low integrative complexity also countering structural violence related instance poverty prejudice discrimination may require comprehensive approach including collaborative work clinical psychologists applying implicit explicit assessment tools originality value documenting links lack among personality variables attitudes towards peace war practical theoretical value may contribute organizational schemes shaped personality structure bearing implications negotiations terms paradigm morton deutsch results show individual differences associations among variables relating remediable likelihood parties differentially likely find negatively positively interdependent situations carrying effective instead bungling actions
assessed osteoporosis management patients admitted rehabilitation acute hip fracture open system community hospital institution fracture liaison service fls pre fls surveyed patients months hip fracture subsequently fls program performed routine consultations recommended lab bone density testing bmd osteoporosis medication fls program outcomes assessed survey patients hip fracture pre fls population hip fracture changed calcium intake changed vitamin intake obtained bmd osteoporosis medication taken hip fracture post fls changed calcium intake changed vitamin intake obtained bmd post fls osteoporosis medicationwas taken patients hip fracture fls program hip fracture patients improved non pharmacologicmeasures use osteoporosis medication
assessed influence race education informants reports cognitive decline community residing older persons receiving services senior health agencies expert consensus panel made diagnoses normal cognition cognitive impairment dementia cind dementia based clinical evaluations standardized neuropsychological testing using population race adjusted norms informants interviewed using informant questionnaire cognitive decline elderly iqcode informants black participants cind reported less cognitive decline lower iqcode scores informants white cind participants even though significant differences participants functional neuropsychological impairments analysis covariance controlled informant education indicated difference iqcode scores attributable fact black informants fewer years education white informants statistically significant difference iqcode scores black white participants dementia conclude racially determined differences perceptions early cognitive decline education may influence informant ratings older persons differences may contribute disparities detection treatment cognitive disorders older black persons
vertical distribution plant physiological composition plays important role vegetation growth carbon stock hyperspectral lidar thought promising solution assess vertical distribution vegetation physiological parameters lai leaf area index chlorophyll content however instrument fully feasible simulation experiment response parameters necessary paper hyperspectral lidar waveform simulated consideration single scatter plant radiative transfer model variation lai chlorophyll along plant height investigated tree scenarios assumed simulation hyperspectral lidar data experiment also carried validate simulation method result showed hyperspectral lidar waveform could reflect variation plant physiological composition facilitate inversion algorithm design could play significant role parameter estimation precision agriculture application future
mindfulness based interventions mindfulness based stress reduction mbsr programme increasingly applied enhancing patients stress management problem solving skills preventing treating mental disorders however generalisability psychosocial counseling remains uncertain aim examine whether abbreviated mbsr based mindfulness stress reduction training mst provided counseling context positive impact mindfulness quality life stress depressive symptoms psychosocial counseling centre chemnitz conducted randomised controlled pilot study comparing mst weekly sessions hours waiting list control group months treatment mst participants displayed higher quality life fewer dysfunctional functional stress management strategies fewer depressive symptoms control participants potential mst could realized successfully short cost effective version mbsr programme achieve positive impact stress management quality life depression providing mst context treatment psychosocial counseling may address shortages health service provision
identification ipid header field designed identify packet communication session main purpose ipid recover fragmentation best knowledge existing ipid based information hiding methods assume ipid number pseudo random number found false paper propose steganographic method exploiting ipid field considering information user data field first analyze ipid distribution various operating systems subsequently put forward simple data embedding method refined mimic ordinary ipid traffic experiments carried results empirically prove proposed method high undetectability compared existing ipid based steganographic methods elsevier ltd rights reserved
influence aggressive violent media children adolescents topic concern several decades research topic suggested short term long term exposure aggressive violent media negatively impact population purpose literature review discuss relevant research topic examine various factors may impact risk influenced type media factors include time spent viewing media content media viewed gender age psychological characteristics family peers various theoretical approaches explaining influence violent media also examined well directions future research published elsevier ltd
data lie space symmetric positive definite matrices sometimes called tensor data play fundamental role applications including medical imaging computer vision radar signal processing open challenge applications find class probability distributions able capture statistical properties data arise real world situations present paper meets challenge introducing riemannian gaussian distributions distributions kind first considered pennec however present paper gives exact expression probability density function first time existing literature leads two original contributions first detailed study statistical inference riemannian gaussian distributions uncovering connection maximum likelihood estimation concept riemannian centre mass widely used applications second derivation implementation expectation maximisation algorithm estimation mixtures riemannian gaussian distributions paper applies new algorithm classification data concretely problem texture classification computer vision showing yields significantly better performance comparison recent approaches
presented simulation model surface tension wettability based physical properties liquids designed use computer graphics due relatively small surface tension forces model useful simulating liquid small volume droplets model used conjunction various fluid simulation methods one popular marker cell selected paper paper describes also simple rapid method determining liquid surface mesh triangles presented method improves final visual effect well suited determining surface droplets simulation method applied create realistic animations flowing liquid droplets different types
osteoclastogenesis essential process bone metabolism induced rankl stimulation glycoprotein member egf transmembrane family established specific cell surface marker murine macrophages study aimed identify role osteoclastogenesis using mouse bone marrow derived macrophages bmms observed mrna level dramatically reduced cells differentiated osteoclasts furthermore osteoclastogenesis decreased high bmms compared low bmms inhibitory effect associated decreased expression nuclear factor activated cells cytoplasmic nfatc ectopic overexpression constitutively active form nfatc rescued anti osteoclastogenic effect completely suggesting anti osteoclastogenic effect mainly due reduction nfatc expression underlying mechanism demonstrated presence abrogated effect rankl phosphorylation creb activated expression ifn beta restored cyclic amp collectively results demonstrate presence suppresses rankl induced osteoclastogenesis impairing expression nfatc via creb ifn beta therefore may hold therapeutic potential bone destructive diseases
natural environment socio economic conditions yellow river basin shown spatial data provide important supporting role spatial information yellow river basin management development analyzing yellow river basin spatial data management application basis research service gis technology platform overall framework key technologies construction ideas sharing service application platform based first national water census spatial data yellow river basin discussed result shows based first national water census spatial data yellow river basin establishment spatial data sharing service platform technology advanced feasible flood control drought water resources regulation management soil conservation supervision control engineering construction management etc provide unified spatial data sharing services meet needs yellow river basin management development spatial information huge social economic benefits
porous organic polymers pops new class porous materials constructed organic molecular building blocks attracted much attention design pops good porosity specific task functionalization still critical challenge work using simple friedel crafts one step reaction one common organic compound methylbenzene monomers polymerized cross linker formaldehyde dimethyl acetal fda produce cost effective non functionalized porous polymer pop moreover amine groups incorporated network post synthetic modification method resulted porous polymer pop presented highly effective removing aqueous solution maximum adsorption capacity max evaluated langmuir model combination experimental results theoretical quantum calculations illustrated amine groups easily form coordination complexes responsible efficient adsorption generated pop could regenerated effectively recycled least four times without significant loss adsorption efficiency hence outstanding adsorption capacity excellent reusability well low cost synthesis create potential polymer pop attractive adsorbent removing toxic metal ions aqueous solution elsevier rights reserved
exposure violence media including television movies music video games represents significant risk health children adolescents extensive research evidence indicates media violence contribute aggressive behavior desensitization violence nightmares fear harmed pediatricians assess patients level media exposure intervene media related health risks pediatricians child health care providers advocate safer media environment children encouraging media literacy thoughtful proactive use media children parents responsible portrayal violence media producers useful effective media ratings office counseling shown effective pediatrics
smoking cessation adolescents considered developmental context enable clinician individualise appropriate assessment management young person seeing whether primary tertiary care setting adolescence time rapid neurocognitive hormonal change factors affected personality behavioural factors well family cultural psychosocial context adolescents uniquely vulnerable smoking initiation nicotine addiction throughout years increased awareness risks smoking using opportunities assess intervene regarding smoking cessation integral clinical practice clinicians seeing young people review discuss demographics adolescent smoking risk factors assessing smoking nicotine addiction importance brief interventions evidence base appropriate interventions particularly high risk groups emphasise innovative training health professionals adolescent smoking cessation elsevier ltd rights reserved
background objectives maternal nutrition affects fetal growth development study evaluates effects milk powder fortified micronutrients docosahexaenoic acid dha prebiotic probiotic bifidobacterium animalis subsp lactis micronutrient status well presence faecal probiotic immune markers pregnant women methods study design randomised double blind placebo controlled trial conducted budi kemuliaan cipto mangunkusumo hospital jakarta total participants randomly allocated receive either completely enriched milk powder intervention group iron vitamin folic acid enriched milk powder control group data collected using standardised measures statistically analysed using independent mann whitney test results baseline micronutrient status participants acceptable except vitamin intervention control groups vitamin zinc total free fatty acid linoleic acid arachidonic acid dha significantly higher intervention group second trimester respectively interleulcin tumor necrosis factor alpha levels significantly vary pregnancy animalis subsp lactis present faeces intervention group control group conclusion milk fortified prebiotic probiotic dha micronutrients increases faecal concentration organism used fortification indonesian pregnant women may represent improvement intra partum maternal gut health
present set matlab octave functions compute measures emergence self organization complexity applied discrete continuous data measures based shannon information differential entropy examples different datasets probability distributions provided show use proposed code
article presents fuel consumption model sefum semi empirical fuel use modeling comparison three models literature experimental database model easy calibrate required parameters provided car manufacturers test database built drivers drove two conditions normal ecodriving trip model evaluation three indicators selected instantaneous fuel use root mean square error cumulated error computation time order evaluate accuracy cumulated instantaneous fuel use estimate computation time model results tend prove model able compute rapidly maximum simulated kilometers matlab comparison models ensuring high accuracy precision cumulated instantaneous fuel use elsevier ltd rights reserved
flapping wings important many biological bioinspired systems investigate fluid mechanics flapping wings possess single flexible hinge allowing passive wing pitch rotation load perform experiments insect scale approximate wing span robotic flapper compare results quasi steady dynamical model coupled fluid structure computational fluid dynamics model experiments measure time varying kinematics lift force two dimensional velocity fields induced flow particle image velocimetry find increasing hinge stiffness leads advanced wing pitching beneficial towards lift force production classical quasi steady model gives accurate prediction passive wing pitching relative phase difference wing stroke pitch kinematics delta small however quasi steady model account effect delta leading edge vortex lev growth lift generation explore relationships lev lift force drag force wing kinematics experiments numerical simulations show wing kinematics flapping efficiency depend stiffness passive compliant hinge dual approach running scale experiments numerical simulations gives useful guidelines choosing wing hinge stiffnesses lead efficient flapping
knee joint involved wide variety arthritides imaging always played major role aiding diagnosis assessing severity diseases plain film radiography traditionally used primary imaging modality radiographic diagnosis arthritis however magnetic resonance imaging mri shows greater sensitivity bone soft tissue features group conditions article reviews imaging features osteoarthritis knee shown mri criteria used diagnose condition also discusses imaging features suggest underlying arthropathy
many treatments eating disorders demonstrated success however patients respond interventions achieve full recovery obvious candidates like diagnosis symptoms generally failed explain variability current study investigated predictive utility personality outcome treatment one hundred thirty adult patients bulimia nervosa eating disorder otherwise specified enrolled intensive multimodal treatment weeks personality assessed neo personality inventory revised neo outcome defined recovered versus still ill also symptom score termination eating disorder inventory edi personality significantly predicted recovery patients symptom improvement patients recovered reported significantly higher levels extraversion baseline still ill assertiveness emerged personality trait best predicting variance outcome study indicates personality might hold promise predictor recovery treatment future research might investigate adding interventions address personality features improves outcome patients
background metabolic syndrome mets associated cancer risk increases risk barrett esophagus precursor lesion esophageal adenocarcinoma primarily absence gastroesophageal reflux disease gerd however authors knowledge little known regarding whether mets associated risk methods using surveillance epidemiology end results seer medicare linked database authors evaluated whether mets associated total cases compared individually matched population controls subset cases able individually matched barrett esophagus controls mets defined using international classification diseases ninth revision clinical modification icd codes period years diagnosis control selection unconditional logistic regression used estimate adjusted odds ratios confidence intervals potential effect modification gerd symptoms sex examined stratified models results found significantly associated mets odds ratio confidence interval compared population controls males association restricted individuals without prior gerd however females mets found associated regardless gerd status effect modification sex observed interaction mets found associated risk compared barrett esophagus controls conclusions older population mets found associated increased risk males without gerd females regardless gerd status given lack association compared barrett esophagus controls mets may impact risk primarily increasing risk precursor lesion barrett esophagus american cancer society
power gas may used store curtailed electricity whilst converting energy vector gas economically viable systems require cheap electricity cheap concentrated source biogas produced anaerobic digestion typically comprises methane system substitutes conventional upgrading system using hydrogen derived surplus wind electricity react increases methane output potential production biogas ireland associated typical wet substrates assessed times greater required potential level curtailed electricity wind energy curtailment ireland assessed conservatively thus limited levels curtailment electricity rather biogas systems shown electricity used produce upgrading biogas system affect savings tonnes cost hydrogen assessed sic renewable methane price electricity sic leads cost compressed renewable gas grass sic drops sic electricity purchased sic elsevier ltd rights reserved
network traffic detection model based swarm intelligent optimization neural network algorithm proposed paper qapso algorithm used optimize basis function center base function width rbf neural network connection weights output layer hidden layer well paper analyzes detection model studied paper example use collected data train network traffic identification system test performance comparison proposed method conventional pso algorithm based hpso algorithm shows proposed method faster recognition speed better recognition accuracy avoids problem falling local optimal solution situation
efficient performance modeling extremely important task yield analysis design optimization analog circuits paper novel regression modeling method based hierarchical shrinkage priors proposed construct hybrid performance models high accuracy low computational cost particular user defined model templates derived design equations general purpose orthogonal polynomials combined together set hybrid dictionary next order avoid shrinking large model coefficients novel regression method based hierarchical shrinkage priors variational bayesian inference adopted model fitting rail rail operational amplifier example demonstrates proposed method achieves error reduction state art approaches without increasing modeling cost
many popular model reduction techniques ensure matching steady state response original system canonical inputs harmonic singularity inputs paper shows steady state response retention simply achieved decomposing forced response transient steady state component applying reduction method first also ensures transient term optimal respect chosen criterion suggested reduction procedure refers state space representations often available systems reduced high order computation transfer functions reliable purpose aforementioned components forced response expressed directly terms original state space representation two benchmark examples high dimensions worked show performance resulting reduced order models compares favourably performance models order determined usual way without explicit consideration steady state response
aim investigate clinical implications infliximab trough levels ifx tls antibodies infliximab ati levels crohn disease patients asian countries methods ifx ati level measured using prospectively collected samples obtained informed consent patients treated asan medical center south korea analyzed correlations ifx tls ati levels clinical activity quiescent active disease based activity index reactive protein level physician judgment patients clinical status enrollment impact concomitant immunomodulators also investigated results study enrolled patients quiescent active disease patients quiescent active diseases median ifx tls respectively median ati levels respectively ati negative positive groups median ifx tls respectively patients without concomitant immunomodulator use differences ifx tls respectively ati levels respectively conclusion ifx ati levels well correlated clinical activity south korean patients findings support usefulness ifx tls ati levels treating patients receiving ifx clinical practice
purpose research consistently shown organizational constraints lead deviant behavioral reactions although many studies investigated personality variables moderators predictors deviance considerably less research considered cross level moderators effects purpose paper draw several related theories test team civility climate cross level moderator organizational constraints interpersonal deviance relationship design methodology approach data collected using paper pencil surveys employees nested within work teams teams employed various industries including healthcare insurance manufacturing engineering financial services findings results hierarchical linear modeling analyses demonstrated effect organizational constraints interpersonal deviance varied significantly across teams addition positive relationship organizational constraints interpersonal deviance attenuated teams high civility climate practical implications organizational constraints may difficult eliminate many workplaces however results suggest developing positive civility climate teams help prevent deviant behaviors may associated experienced constraints originality value one first studies examine civility climate shared property team cross level moderator findings research contribute theories deviant organizational behavior highlighting critical role variables emanating levels analysis beyond individual
allergies indigestion problems increased society increasing wheat consumption among wheat proteins omega gliadins omega gliadins high molecular weight hmw glutenin known major factors responsible allergic response indigestion certain low molecular weight lmw glutenin subunits also able promote local inflammation share common epitopes omega gliadins known different wheat cultivars different combinations hmw lmw glutenins investigated relationship composition lmw glutenins degree allergic response indigestion extent allergic reaction indigestion characteristics response six different wheat cultivars compared patterns change blood glucose level time employed measure indigestion quite different depending type wheat cultivars extent allergic response measured histamine ige levels also quite different depending type wheat cultivars addition extents correlated patterns lmw glutenin dna hmw lmw glutenin protein various wheat cultivars results present study suggest factors together factors studied need considered better explain physiological phenomena variation blood glucose level allergic response
paper novel teaching learning based optimization tlbo algorithm degree freedom proportional integral derivative dof pid controller proposed automatic generation control agc initially widely used two area thermal system considered gains pid dof pid controller optimized employing tlbo algorithm supremacy proposed dof pid controller shown comparing results recently published technique conventional bfoa hbfoa pso based controllers system additionally proposed approach extended multi source power system thermal hydro gas power plant advantage proposed approach demonstrated comparing results recently published approaches sensitivity analysis performed demonstrates ability proposed approach wide changes system parameters finally proposed approach investigated random load variation elsevier ltd rights reserved
objectives delays diagnosis occur complex regional pain syndrome crps define prospectively demonstrate novel bedside tests measuring body perception disruption identify patients crps postfracture methods objectives study define validate bedside tests identify prevalence positive tests patients crps chronic pain conditions assess clinical utility sensitivity specificity positive predictive value negative predictive value identifying crps within fracture cohort single teaching hospital prospective cohort study recruits pain free volunteers patients chronic pain conditions four novel tests finger perception hand laterality identification astereognosis body scheme report five questionnaires brief pain inventory upper extremity functional index lower extremity functional index neglect like symptom questionnaire hospital anxiety depression score assessed multidimensional pain experience results best performing tests prospective monitoring fracture patients showed fracture patients total finger misperception abnormal report initial testing developed persistent pain formal diagnosis crps discussion novel signs reliable easy perform present chronic pain patients significant clinical utility predicting persistent pain fracture group thereby allowing targeted early intervention
objectives study identify risks green retrofit projects singapore analyze risk criticalities compare risk criticalities conventional green retrofit projects provide mitigation measures critical risks twenty risks mitigation measures identified literature review questionnaire survey performed professionals experienced green retrofits five post survey interviews conducted results indicated post retrofit tenants cooperation risk top risk risks critical green retrofits conventional retrofits additionally mitigation measures obtained significant agreement
primary disturbance agent fire significantly influences local processes services forest ecosystems although variety remote sensing based approaches developed applied landsat mission imagery infer burn severity spatial resolution forest burn severity still seldom assessed fine spatial scales high resolution vhr data assessed forest fire occurred april long island new york within pine barrens region unique imperiled fire dependent ecosystem northeastern united states mapping forest burn severity explored fine spatial scales first time using remotely sensed spectral indices set multiple endmember spectral mixture analysis mesma fraction images temporal pre post fire event worldview imagery spatial resolution first evaluated approach using validation points sub crown scale per severity class unburned low moderate high severity post fire color aerial ortho photos validated burn severity mapping geo referenced dominant tree crowns crown scale fixed area plots inter crown scale post fire aerial ortho photos measured crown information twenty forest inventory plots approach accurately assess forest burn severity sub crown overall accuracy kappa value crown overall accuracy kappa value inter crown scales variation estimated burn severity ratings geo composite burn index cbi work highlights forest burn severity mapping vhr data capture heterogeneous fire patterns fine spatial scales large spatial extents important since ecological processes associated fire effects vary scale vhr approaches could significantly advance ability characterize fire effects forest ecosystems elsevier inc rights reserved
paper presents flower pollination algorithm fpa tuned fuzzy logic controlled flc synchronous buck converter sbc integrated wave supercapacitor hybrid energy system order compensate irregular wave effects electrical side wave energy converter wec unit charged solar panels connected parallel wec system sbc controlled provide reliable stable voltage load order test performance designed flc classical proportional integral derivative pid controller also employed controllers optimized fpa pretty new optimization algorithm well known optimization algorithm particle swarm optimization pso minimize integral time weighted absolute error itae performance index also error based objective functions considered entire energy system controllers developed matlab simulink realized experimentally real time applications done controller board simulation experimental results show fpa tuned fuzzy logic controller provides lower value performance indices conventional pid controller reducing output voltage sags swells wave energy system index terms fuzzy
study aimed assess diagnostic prognostic value anti mutated citrullinated vimentin mcv antibodies early rheumatoid arthritis vera established rheumatoid arthritis seventy one patients undifferentiated arthritis months duration established rheumatic diseases healthy individuals included study anti mcv anti cyclic citrullinated peptide ccp antibodies rheumatoid factor determined hand radiographs recorded patients assessed prospectively years hand radiographs repeated diagnostic performance anti mcv studied receiver operating characteristic roc curves evaluation sensitivity specificity likelihood ratios forty six percent patients progressed years vera patients sensitivity anti mcv compared anti ccp specificity compared anti ccp anti mcv detected vera patients negative anti ccp established anti mcv sustain diagnostic performance multivariable analysis anti mcv anti ccp showed significant correlation radiographic progression vera patients established anti mcv anti ccp associated active disease joint damage multivariate analysis strongest factors radiographic damage disease duration haq score conclusion patients early anti mcv predict progression radiological damage therefore anti mcv antibody testing may useful every day practice
analog signal processing current mode regime offers several advantages voltage mode counterpart although current mode circuits exhibit better noise performance fully differential topologies may employed improve noise cancellation account common mode rejection properties paper presents fully differential first order low pass high pass pass filter sections operating current mode recently introduced digitally controllable differential voltage current conveyor dvcc chosen active building block programmability filter characteristics digital control word demonstrated
commentary argues rather providing exhaustive review elson ferguson discuss selective sample empirical studies violent video game use corroborate claim systematic evidence link violent video game play aggression evaluating evidence authors portray biased picture current state knowledge media violence effects fail distinguish aggression violence everyday clinical forms aggression furthermore misrepresent key constructs mediation moderation external validity discredit methodologies used assess aggression media violence use paper moves debate backward rather forward falling behind existing meta analytic studies consider much wider balanced range studies
past years efforts made designing novel efficient semiconductor based heterojunction photocatalyst maximize capture conversion efficiency solar energy work unique tio hollow sub microspheres thss znins zis flower like microspheres combined facile hydrothermal method novelly applied photocatalytic metronidazole mtz degradation effects thss physicochemical properties photocatalytic performance zis systemically investigated optimal weight ratio ths zis composite found furthermore various technologies photoluminescence surface photovoltage spectra sps electrochemical impedance spectra eis used verify intimate contact highly efficient charge carriers transfer ths zis components underlying photocatalysis mechanism also carefully surveyed proposed hydroxyl radicals center dot monitoring radical trapping experiments elsevier rights reserved
according developmental niche theory members different cultural ethnic groups often distinct ideas children need become well adapted adults beliefs reflected parents long term socialization goals children study test whether specific themes deemed important literature diverse families united states strong black woman sbw marianismo familismo evident mothers long term socialization goals participants included mothers teenage daughters low income city united states latina african american european american white socialization goals assessed sort task important traits woman possess content analysis open ended responses values mothers hoped would transmit daughters become adults results ancovas logistic regression indicate significant racial ethnic differences tasks consistent hypotheses sort task african american mothers put importance women possessing traits independence mothers racial ethnic groups similarly likely emphasize self confidence strength hoped transmit daughters contrary expectation latina mothers emphasize social traits sort however open ended responses likely focus importance motherhood one aspect marianismo familismo overall results suggest mothers long term socialization goals incorporate culturally relevant values considered important african american latino families
paper dimensional generalized type kadomtsev petviashvili equation investigated used describe weakly dispersive waves propagating quasi media fluid mechanics based bell polynomials multiple soliton solutions bilinear form reductions derived respectively furthermore using riemann theta function construct one two periodic wave solutions equation finally study asymptotic behavior periodic wave solutions implies periodic wave solutions degenerated soliton solutions small amplitude limit elsevier ltd rights reserved
combination vision ray radiography proposed enable low cost generally applicable online inspection internal quality horticultural potentially products underlying concept assumes shape product known beforehand deformable shape model vision system used combination shape model accurately determine complete outer surface shape sample shape voxelized generate reference product ray radiograph simulated compared measured radiograph hence revealing presence defects disorders advantages method small deviations internal density detected easily since cumulative information bulk object shape removed furthermore specific detection algorithms developed different types defects since method directly identify deviations ideal validation two datasets comparison two reference detections methods classical image processing human operator shows proposed method reliably accuracy detect defects larger radius densities differences sample defects small voids reliably accuracy detected radius corresponding volume less elsevier rights reserved
purpose paper examine relation frequency watching television playing video games presence violent contents one hand direct physical verbal indirect peer aggression among students hand respondents students male female seventh eighth forms elementary schools urban rural areas average age research conducted february using instruments assessment students media habits direct indirect aggression scales bjorkqvist results correlation regression analyses show students watch television often likely manifest physical indirect violence towards peers frequently watch violent programmes likely manifest three forms violent behaviour towards students watching frequency amount violent content among predictors direct physical verbal well indirect violent behaviour peers students frequently play computer video games also frequently manifest physical verbal violence peers students play games involving significant amount violence often manifest three forms violent behaviour peers frequency playing amount violence games predictors physical verbal violence relation playing games indirect violence lid appear significant results recent research suggest exposure violence media increases risk aggressive violent peer behaviour real world must also stressed might first glance appear minor statistical effects may fact serious practical consequences since large part population exposed risk factors
laboratory experimentation plays essential role engineering scientific education virtual remote labs reduce costs associated conventional hands labs due required equipment space maintenance staff furthermore provide additional benefits supporting distance learning improving lab accessibility handicapped people increasing safety dangerous experimentation paper analyzes literature virtual remote labs beginnings identifying influential publications researched topics interest topics evolved along way bibliographical data gathered isi web science scopus grc examined using two prominent bibliometric approaches science mapping performance analysis elsevier ltd rights reserved
article analyses knowledge needed understand computer program within philosophy information floridi method levels abstraction applied relation ideal programmer modern computer seen together informational organism results obtained mental experiment known knowledge game applied relation explain programmer know order program modern computer particular analysis clearly shows non conscious agents hopes write significant programs two main objections presented attacked corresponding counterobjections
liver transplantation outcomes significantly improved past decades owing largely introduction effective immunosuppression medications comprehension unique immune microenvironment liver led development newer molecular targeted therapeutics understanding mechanism action adverse effect profiles medications crucial appropriate management posttransplant patients review author describes immunologic response elicited liver transplantation chronicles various immunosuppressant drug classes discusses evidence behind use evaluates management special subpopulations posttransplantation patients
commercial carbon fibers coated brush like layer zno nanowires using seeded chemical bath deposition single carbon fibers large tows functionalized way exploiting electrical conductivity carbon fibers functional properties zno nanostructures demonstrated intersection crossing two functionalized carbon fibers act piezoelectric strain sensor also chemoresistive gas sensor small volume added nanostructures prevents delamination issues crossing configuration typical carbon fiber fabrics used composites paves way transform typical texture simple mechanical structural properties smart material noninvasive integrated arrays micron scale sensors elsevier rights reserved
paper presented criterion identification heat transfer regime convection natural forced mixed making use mathematica system symbolic computation capabilities criterion based comparison buoyancy viscous forces analysis realized interior two vertical plates submitted uniform heat flux density steady laminar state fully developed flow thus proposed dimensionless numbers product rire representative parameter order identify convective thermal regime instead idea based dimensionless number richardson grashof authors published elsevier ltd
late onset hypogonadism loh relatively common conditions affecting aging male aim review summarize available evidence regarding loh interaction general health loh often comorbid obesity several chronic diseases reason lifestyle modifications strongly encouraged loh subjects obesity type diabetes mellitus tdm metabolic syndrome mets good treatment balance chronic diseases medical therapy loh individualized depending etiology disease patient expectations available evidence seems suggest testosterone replacement therapy able improve central obesity subjects mets glycometabolic control patients mets tdm well increase lean body mass hiv chronic obstructive pulmonary disease along insulin resistance mets peripheral oxygenation chronic kidney diseases however recognized number studies benefits supplementation limited draw final conclusions longer larger studies needed better clarify role trt chronic conditions elsevier ltd rights reserved
indirect inference method implemented class stochastic volatility models financial data based non gaussian ornstein uhlenbeck processes first quasi likelihood estimator derived approximative gaussian state space representation model next data simulated model given parameter values indirect inference estimator obtained minimizing weighted mean squared error sense score vector quasi likelihood function simulated data score vector evaluated quasi likelihood estimator obtained real data method applied euro norwegian krone nok dollar nok daily exchange rate data simulation study reveals quasi likelihood estimator may large bias even large samples indirect inference estimator substantially reduces bias accompanying package interfaces code documented downloaded elsevier rights reserved
introduction use beta emitters one effective methods palliation bone metastasis risk normal tissue toxicity evaluated bone pain palliation treatment methods study monte carlo simulation code mcnpx used simulation bone phantom model consisted bone marrow bone soft tissue specific absorbed fractions calculated monoenergetic electrons photons eight beta emitters beta gamma factor absorbed dose cumulative dose mentioned radionuclides obtained selection radionuclides optimal radiation characteristics results results show gives higher local dose source organ fewer side effects critical organ including bone marrow comparison radionuclides cumulative dose versus time shows long time long half life radionuclides delivering higher dose comparison short half radionuclides conclusion according results low energy beta emitters used bone pain palliation especially vertebra different combination radionuclides used improving therapeutic effects tumors different size
economic environmental benefits brought electric vehicles evs fully delivered unless vehicles fully partially charged renewable energy sources res photovoltaic system pvs nevertheless charging management problem parking station integrated res challenging due uncertain nature local res generation paper aims address difficulties deploying energy storage system ess parking stations exploiting charging discharging scheduling evs achieve better utilization intermittent pvs charging real time charging optimization scheme also formulated using mixed integer linear programming milp coordinate charging discharging power evs along power dispatches power grid ess based vehicles charging discharging priorities electricity price preferences extensive simulations show proposed approach maximizes satisfaction owners terms fulfilling charging discharging requests also minimizes overall operational cost parking station prioritizing utilization energy pvs ess scheduling every charging discharging
objectives characterise risk factors chronic idiopathic normocytic anaemia cina older people particularly role age associated renal impairment methods patients aged years admitted medical unit months assessed secondary causes anaemia including chronic kidney disease ckd excluded cina defined haemoglobin men women least months without apparent cause renal function determined estimating creatinine clearance crcl using cockcroft gault formula glomerular filtration rate gfr using modification diet renal disease mdrd chronic kidney disease epidemiology collaboration ckd epi formulas results cina controls mean estimates renal function significantly lower cases compared controls risk cina increased respectively unit decrease crcl mdrd egfr ckd epi egfr independent age covariates adjusted odds ratios cina crcl mdrd ckd epi egfr min respectively covariates model independently associated cina included advanced age diabetes mellitus use angiotensin converting enzyme inhibitor acei angiotensin receptor blocker arb history dementia living residential care facility conclusions age associated renal impairment independently contributes cina potential risk factors cina include advanced age acei arb use
paper focuses analysis electrical network loadability power flow model extended consider secondary voltage control unlike conventional power flow number power flow variables increased keeping constant number equations application newton method solve set nonlinear equations requires solution determined linear system iteration brings flexibility obtain operational solutions taking account performance indexes related either iterative process power system operation called extended power flow method computationally implemented tests performed considering different loadability initial solutions ieee bus test system used illustrate application proposed methodology
voltage drifting islanding detection methods idms force voltage point common coupling pcc move outside appropriate limits voltage protection disconnects distributed generation units kind idms possess advantage keeping micro grid energized islanding occurrence active idms without forcing islanded micro grid lose stable operation degrade power quality perturbation injection study active idm proposed makes second harmonic pcc voltage drift suddenly islanding occurrence pass predefined threshold value without affecting fundamental component islanding detected method deactivated voltage frequency remain expected limits conditions power balance another advantage proposed method decreases second harmonic pcc voltage grid connected mode improves power quality system unlike active idms test results show proposed method detects islanding occurrence multi inverter system also correct performance proposed method shown non islanding conditions paper simulations performed using pscad emtdc software
microcontroller featuring voltage stacked memory logic presented involved connecting power domains memory logic series ground one power domain connected positive supply rail paper arm cortex peripherals powered rom sram powered since memory logic general draw different supply currents midrail provided chip switched capacitor voltage regulator scvr allow direct comparison voltage stacking conventional single supply turned configuring scvr power memory logic turning voltage stacking results power conversion efficiency active converter area reduced despite use smaller scvr voltage stacking reduces supply noise output voltage drops
wind tunnel test large scale sectional model computational fluid dynamics cfd employed purpose studying aerodynamic appendices mechanism suppression vortex induced vibration viv paper takes hongkong zhuhai macao bridge example conduct wind tunnel test large scale sectional model results wind tunnel test show crash barrier induces vertical viv cfd numerical simulation results show distance curb crash barrier long enough accelerate flow velocity resulting approximate stagnation region forming behind two continuous vortex shedding occurs giving rise vertical viv end according types wind fairing trapezoidal airfoil smaller airfoil proposed accelerate flow velocity crash barrier curb order avoid continuous vortex shedding cfd numerical simulation velocity field measurement show flow velocity measuring points case section airfoil wind fairing increased greatly compared results original section energy reduced considerably natural frequency indicating wind fairing accelerate flow velocity behind crash barrier wind tunnel tests case sections three different countermeasures mentioned conducted results compared original section show three different countermeasures used control viv varying degrees
image registration become crucial step wide range imaging domains computer vision computer graphics core image registration consists determining transformation induces best mapping two images problem ill posed also difficult handle due high size images high dimension transformation parameter spaces computing actually optimal solution practically impossible transformations assumed continuous defined article initiate exploration new way considering image registration since digital images basically defined discrete framework transformation spaces despite potentially high complexity actually remain finite allowing development explicit exploration parameter space via discrete optimization schemes propose analysis basis registration considering rigid registration images show particular problem handled fully discrete fashion computing locally combinatorial structure parameter space discrete rigid transformations navigating flight within space via gradient descent paradigms registration framework applied real imaging cases emphasizing relevance approach potential usefulness extension higher dimension images richer transformations elsevier rights reserved
four parts opamp oparz manufactured analog devices tested chips compared visually specialized software forms ionization response three checkpoints registered maps response amplitudes crystal surface constructed fixed crystals samples various spite identical crystals marking tid behavior various samples observed
objective although enuresis relatively common early childhood research exploring antecedents implications surprisingly limited perhaps condition typically remits middle childhood method examined prevalence predictors prognostic factors outcomes primary enuresis large multi method multi informant prospective study community based sample children followed age years age years results found sample met criteria lifetime enuresis suggesting commonly occurring childhood disorder males twice likely females lifetime diagnosis significant age predictors developing primary enuresis age included child anxiety low positive affectivity maternal history anxiety low authoritative parenting addition poorer global functioning depressive anxiety symptoms age years predicted greater likelihood persistence age age years children received diagnosis primary enuresis remission continent however children remitted exhibited higher rate attention deficit hyperactivity disorder adhd greater adhd depressive symptoms age compared children lifetime history enuresis conclusion results present study underscore clinical significance primary enuresis demonstrate shows strong antecedent prospective associations psychopathology findings also highlight possible role parenting development enuresis
felsenstein phylip package molecular phylogeny tools used globally since programs receiving renewed attention character based user interface advantage scriptable use large scale data studies based super computers massively parallel computing clusters however occasionally found phylip consense program output text file displays two divided bootstrap values cluster result table happens output newick tree file incorrectly assigns last value cluster disturbs correct estimation consensus tree ascertained cause aberrant behavior bootstrapping calculation rewrite consense program source code outputs bootstrap values without redundancy result table newick tree file appropriate corresponding bootstrap values furthermore developed add program shell script add bootstrap fastatre bsh generate newick tree containing topology branch lengths inferred original data along valid bootstrap values actualize automated inference phylogenetic tree containing originally inferred topology branch lengths bootstrap values multiple unaligned sequences respectively programs downloaded https github com shimadamk phylip enhance elsevier inc rights reserved
present air cooling systems still raise several unsolved problems due conditions imposed environment terms temperature pollution levels present paper investigates impact engine cooling degree upon performances important specific power desired low possible fuel consumption technical solution advanced authors consists constructing flux compressor enhance engine performances flux axial compressor accomplishes two major functions cools engine also turbocharges present paper investigates temperature changes corresponding fresh load use flux axial compressor compressor economically simple compact offers optimal response low rotational speeds engine two compression steps used influence relative coefficient air temperature drop upon working agent temperature intercooler exit also investigated present work variation thermal load coefficient report working agent temperature also investigated engine cooling variation average combustion temperature analyzed correlation thermal load coefficient temperatures working fluid exit cooling system exergetic analysis conducted upon influence cooling degree motor fluid gases resulted combustion process
phase shift modulation psm commonly used technique controlling active power flow resonant converters although traditionally developed analog modulation scheme psm increasingly implemented digitally conjunction advanced multivariable digital controllers online efficiency optimization algorithms analog psm known introduce additional dynamics small signal standpoint analysis disclosed study indicates discrete time uniformly sampled psm introduces transport delay small signal nature furthermore close analogy theory uniformly sampled pulse width modulators delay depends modulator carrier type well converter operating point paper first clarifies modeling procedure describing small signal dynamics uniformly sampled phase shift modulators second provides extension traditional phasor modeling digital phase controlled converters allowing account additional modulator dynamics design closed loop compensation theoretical findings validated via simulation experimental results
attenuation effect influence precision inversion earth physical properties solving geophysical inverse problems utilizing seismic data therefore using viscoelastic acoustic wave equation suitable actual situation paper based seismic forward modeling considering attenuation effect frequency space domain inversion algorithm inverse scattering based viscoelastic acoustic equation applied frequency domain reconstruct seismic velocity distribution real complex velocity used individually inversion process depending whether earth attenuation effect considered meanwhile regularization inversion parameter total variation makes inversion approach stable frequency divided inversion strategy adopted lower frequency inversion result set background model higher frequency inversion background model remains constant inversion process particular frequency inversion method need reconstruct forward operator iteration makes efficient order improve efficiency inversion calculation mpi parallel computing strategy used procedure inversion numerical example inversion algorithm applied without considering attenuation effect respectively results former approach closer real velocity model latter match real model algorithm achieve high resolution velocity reconstruction results complex geological models shallow middle layers provide accurate velocity information seismic data processing inversion resolution ideal deep layer due attenuation seismic energy
background important outcome measure among rheumatoid arthritis patients functional disability may contribute unemployment loss work productivity impaired quality life however little known risk factors functional disability chinese patients study aimed examine prevalence functional disability chinese patients explore factors associated health assessment questionnaire disability index haq methods total patients cross sectional study underwent standardized laboratory examinations responded questionnaire demographic data haq functional disability compliance questionnaire rheumatology cqr medication adherence hospital anxiety depression scale hads psychological status short form health survey quality life pain grip pinch strength disease activity large joint mobility recorded independent samples tests chi square analyses logistic regression modeling used analyze data results mean age patients years approximately patients mainland china experience functional disability defined haq score long disease duration pain high disease activity larger number tender swollen joints high reactive protein crp level decreased grip strength limitation shoulder elbow wrist knee ankle motion associated haq participants functional disability tended severe depressive symptoms lower quality life compared individuals without functional disability stepwise logistic regression analyses found limitation wrist extension lower body pain score explained higher haq score conclusions present study reported functional disability common chinese patients low quality life limitation joint mobility great impacts functional disability chinese patients targeted culturally sensitive interventions strengthened delay onset disabilities population
background dientamoeba fragilis commonly identified children primary care suspected cause gastrointestinal disease objective determine association fragilis colonization gastrointestinal symptoms children methods performed cross sectional study children presented primary care gastrointestinal symptoms associations fragilis colonization specific symptoms explored means logistic regression analyses asymptomatic siblings cases invited control subjects case control analysis explored association fragilis gastrointestinal symptoms conditional logistic regression analysis results cross sectional study children included median age years interquartile range boys colonization fragilis present children absence fragilis associated soft watery stool odds ratio confidence interval chronic diarrhoea fatigue case control analyses included children group dientamoeba fragilis colonization observed often cases controls adjustment age sex conclusion dientamoeba fragilis common parasite children without gastrointestinal symptoms anomalous finding association absence fragilis soft watery stools chronic diarrhoea fatigue inexplicable study suggests fragilis colonization increase risk gastrointestinal symptoms
article revisit problem supporting two dimensional range successor queries present data structure lglg words space lglgn query time improves work nekrich navarro factor lgn query time factor element space cost arbitrary positive constant data structure matches state art two dimensional range emptiness queries achieves optimal query time structure fruitful applications computational geometry text indexing elsevier rights reserved
parasitic infections serious public health problem cause anemia growth retardation aggression weight loss physical mental health problems especially children numerous studies performed intestinal parasitic infections iranian preschool school children however study gathered analyzed information systematically aim study provide summary estimates available data intestinal parasitic infections iranian children searched english persian databases unpublished data abstracts scientific congresses using terms intestinal parasite giardia cryptosporidium enterobiusvermicularis oxyure school children preschool iran conducted meta analysis using stata statistical tests value less considered significant among publications searched result eligible inclusion study prevalence rate intestinal parasitic infections prevalence protozoa helminthic intestinal infections non pathogenic parasites respectively affected males females rate infection preschool school children respectively giardia enterobiusvermicularis entamoeba coli common among protozoa helminthic non pathogenic infections respectively data analyses indicated prevalence intestinal parasitic infection decreasing iranian preschool school children improvement sanitation personal hygiene increased awareness people seasonal variations health education effective reducing parasitic infections different communities published elsevier
seasonality fruits vegetables makes impossible consume use throughout year thus numerous processing efforts made offer alternative fresh consumption application prolong availability market drying received special attention currently method considered one common ways obtaining food pharmaceutical products natural sources paper demonstrates weakness common drying methods applied fruits vegetables possible ways improve quality using different drying techniques combination emphasis microwave energy particular attention drawn combined drying assistance vacuum microwaves quality dried products ascribed chemical properties including content polyphenols antioxidant capacity volatiles well physical parameters color shrinkage porosity texture fields quality classification considered taking account sensory attributes energy aspects perspective possible industrial applications conclusion promising way improving quality dried fruit vegetable products hybrid drying consisting osmotic dehydration concentrated fruit juices followed heat pump drying vacuum microwave finish drying
density functional theory calculations performed study structural electronic magnetic properties hexagonal nias type cubic rock salt type cubic zincblende type crbi vbi compounds free surfaces crbi vbi interface crbi vbi insb antiferromagnetic afm nias structure ground state structure bulk crbi vbi structure crbi vbi found ferromagnetic half metals total moments per formula unit respectively calculated surface energies framework initio atomistic thermodynamics indicated terminated surfaces crbi vbi lowest energy entire accessible region chemical potentials respect terminated surfaces half metallic characteristic preserved terminations half metallicity disappeared terminations half metallicity also retained crbi insb vbi insb interfaces introducing crbi vbi promising candidates possible epitaxial growth insb semiconductor substrate spintronic applications
sexuality family planning program fpp largely overlooked even though practice birth control inextricably connected procreative behavior focusing sexuality discourse fpp south korea article examines process constructing intimacy sphere making modern families non western society fpp adopted national policy implemented military junta repressive dictatorship however contrary public perception fpp coercive intervention people personal lives fpp took critical stance regarding repression sexuality stressed pleasurable aspect sexuality disconnecting procreation associating love analyzing unexpected aspect article highlights emphasis association sex love marriage western concept ushered modern korean family postcolonial context women sexual desire justified encouragedbut conversely women autonomy became bound sexual dimension embedded marital relationship core south korean modern family
introduction bipolar disorders frequent mood disorders associated poor prognosis mainly due high relapse rate depressive relapses may follow seasonal cyclicality bright light therapy blt established treatment choice seasonal affective disorder sad use blt seasonal unipolar depression well known scientific literature much poorer management seasonal depressive episodes addition specificities related must taken account methods conducted comprehensive review using medline google scholar databases august using following keywords combination bipolar disorder light therapy phototherapy papers included review published english french language peer reviewed journal study enrolled patients sad diagnosis made according dsm icd criteria results blt considered among first line treatments sad size effect similar antidepressants studies distinguish patients unipolar bipolar disorders however demonstrated significant risk blt patients mood shift thus important therapeutic adaptation corresponds use effective mood stabilizer antidepressant another therapeutic adaptation first intention times exposure light shifted morning midday review also includes therapeutic guidelines regarding management blt seasonal bipolar depressive episodes discussion specific data seasonal bipolar depressive episodes literature review highlighted blt handled regular antidepressant treatment patients suffering seasonal bipolar depressive episodes encephale paris
film coating pharmaceutical tablets often applied influence drug release behaviour coating characteristics thickness uniformity critical quality parameters need precisely controlled optical coherence tomography oct shows high potential line quality control film coated tablets also line monitoring coating processes however line quality control tool must able determine coating thickness measurements automatically real time study proposes automatic thickness evaluation algorithm convex tables provides thickness measurements within beside segmentation coating layer optical distortions due refraction beam air coating interface corrected moreover line monitoring tablets might oblique orientation needs considered algorithm design experiments conducted tablet rotated specified angles manual automatic thickness measurements compared varying coating thicknesses angles rotations beam displacements lateral displacement successive depth scans automatic thickness determination algorithm provides highly accurate results angle rotation degrees computation time reduced thickness measurements introducing feasibility constraints algorithm
consider problem finding meaningful correspondences models related necessarily similar shapes quite different point point map always appropriate focus paper method build set correspondences shape regions parts proposed approach exploits variety feature functions shapes makes use key observation points matching parts similar ranks sorting corresponding feature values algorithm proceeds two steps first build affinity matrix points two shapes based feature rank similarity many feature functions define notion stability pair regions respect affinity matrix obtained fixed point nonlinear operator method yields family corresponding maximally stable regions two shapes used define shape parts observe instance biclustering problem related solving constrained maximal eigenvalue problem provide algorithm solve problem mimics power method show robustness output noisy input features well convergence properties obtained part correspondences shown almost perfect matches isometric case also semantically appropriate even non isometric cases provide numerous examples applications technique example sharpening correspondences traditional shape matching algorithms
paper new linear bioinspired actuator developed actuator made mimic biological muscle structure function ionic polymer metal composites ipmc smart material used emulate motion cross bridges biological muscle dynamic model proposed actuator developed using wave propagation technique modeling simulation bioinspired actuator shows one muscle unit actuator produces maximum force axial displacement step maximum axial displacement total muscle unit length sixteen ipmc sets used set contains three ipmc segments connected series length width height segment respectively total muscle unit length diameter respectively
experiment examined user generated comments crime news article attribute reported crime local residents predispositions affect individuals processing news reality perception participants viewed regionalism invoking comments estimated crime rates featured region higher exposed regionalism irrelevant regionalism counterbalancing comments effects pronounced stronger regional self identity moreover read regionalism related comments either regionalism invoking regionalism counterbalancing recalled better locations featured focal subsequent yet unrelated news articles attributed greater responsibility news media coverage persistence regionalism compared viewed regionalism irrelevant comments
recently researchers begun investigate function memory evolutionary history according nairne colleagues nairne pandeirada thompson nairne thompson pandeirada best mnemonic strategy learning lists unrelated words may one addresses problems pleistocene ancestors faced fitness relevant problems including securing food water well protecting predators survival processing shown promote better recall recognition memory many well known mnemonic strategies pleasantness ratings imagery generation etc however survival advantage extend types stimuli tasks current review presents research replicated nairne original findings addition research designs fail replicate survival advantage words specific manipulations survival processing appear benefit memory strategies potential mechanisms survival advantage described emphasis plausible proximate mechanisms outline memory processes may contribute advantage although ultimate mechanism may congruity survival scenario pleistocene problem solving
paper hirota bilinear method extended new kdv hierarchy variable coefficients result one soliton solution two soliton solution three soliton solutions obtained uniform formula soliton solution derived thanks arbitrariness included functions obtained solutions possess rich local structural features like ridge soliton concave column soliton shown hirota bilinear method used constructing multi soliton solutions hierarchies nonlinear partial differential equations variable coefficients
compare calibration variability risk prediction models estimated using various approaches combining information new predictors termed markers parameter information available variables earlier model estimated large data source assess performance risk prediction models updated based likelihood ratio approaches incorporate dependence new old risk factors well approaches assume independence naive bayes methods study impact estimating fitting single model cases non cases distribution new markers exponential family fitting separate models cases non cases also evaluate new constrained maximum likelihood method study updating risk prediction model new data arise cohort extend available methods accommodate updating new data source case control study create realistic correlations predictors also based simulations real data response antiviral therapy hepatitis studies recommend method fit using single model constrained maximum likelihood copyright john wiley sons ltd
paper presents new electronic vernier fringe counter wavelength measurement diode laser scanning interferometer system intended low cost alternative commercial systems used gauge block calibration counter stage phase coincidence detector made microcontroller high speed cmos logic achieve required resolution microcontroller also synchronize elements make fully automated measurement system electronic design improves resolution electronic counters previous designs
purpose aim study evaluate health science students healthy life behaviors material methods sample population composed students attending health science schools medicine dentistry midwifery nursery cukurova university data collected anonymous questionnaire health promotion lifestyle profile scale nutrition physical activity stress management interpersonal relationships spirituality healthy responsibility results students female mean age years found mean score health promotion lifestyle profile scale middle level highest score taken spiritual growth subscale lowest one taken physical activity subscale significant relation found age groups mean scores males got higher score physical activity subscale females got higher scores subscales scores students attending medicine school lower compared fields conclusion health science students health professionals role models future considered results study may raise awareness may guide interventions elevate students healthy life behaviors better level
objective examine outcomes clinical procedures renal angiomyolipoma associated tuberous sclerosis complex tsc based national health claims databases methods retrospective cohort study selected two cohorts tsc patients underwent either embolization nephrectomy either partial complete renal angiomyolipoma years based claims diagnosis codes estimated prevalence rates angiomyolipoma related conditions embolization nephrectomy related conditions pre post baseline periods respectively made cross year cross period comparison rates repeated measures analysis methods results embolization cohort nephrectomy cohort mean baseline ages years males respectively intervention embolization cohort statistically significant reductions gross hematuria retroperitoneal hemorrhage abdominal mass increases hypertension renal mass unspecified disorder kidney ureter anemia renal insufficiency similarly nephrectomy cohort saw statistically significant reductions gross hematuria flank pain abdominal mass increases hypertension renal insufficiency anemia embolization associated post procedure increases renal mass unspecified kidney ureter disorder disorders kidney ureter non acute renal insufficiency flank pain renal insufficiency etc nephrectomy associated post procedure increases postoperative ileus pain headache paralytic ileus etc conclusions embolization nephrectomy effective associated increases certain angiomyolipoma related conditions embolization effect gross hematuria retroperitoneal hemorrhage abdominal mass might subside intervention year
memristor resistor memory exhibits pinched hysteretic relationship cyclic voltammetry recently found memristors electrical circuitry plants seeds publications literature possible existence memristors electrical differentiators fruits found electrostimulation golden delicious arkansas black apple fruits bipolar periodic waves induces hysteresis loops pinched points cyclic voltammograms low frequencies mhz mhz high frequencies khz pinched hysteresis loop transforms non pinched hysteresis loop instead single line ideal memristors amplitude electrical current depends capacitance fruit tissue electrodes frequency direction scanning electrostimulation electrical circuits apple fruits periodic voltage waves also induces electrotonic potential propagation due cell cell electrical coupling electrical differentiators differentiator electrical circuit output circuit approximately directly proportional rate change input information gained electrostimulation used elucidate observe electrochemical electrophysiological properties electrical circuits fruits elsevier rights reserved
paper presents modified design approach well practical effective neural network efficiency estimation procedure permanent capacitor single phase induction motor spim standard industrial motor frame sizes along current design trends larger lengths smaller diameters taken account likely presented literature context computer aided design approach spim based mainly classical output coefficient proposed first numerous simulations using finite elements method fem conducted order verify proposed procedure investigations regarding number stator rotor slots performed secondly based previous results neural network scheme proposed order estimate efficiency spims various stator rotor slots combinations different output power seen proposed methodology verified satisfactorily could great use aid tool industrial spim designers
objective many inflammatory rheumatic diseases affect patients childbearing age concern expressed safety biologic drugs pregnancy study evaluated effects anti tumor necrosis factor alpha tnf alpha agents pregnancy foetal outcomes methods thirty eight pregnancies followed prospectively november february information patients exposure anti tnf alpha disease activity dmard therapy pregnancy foetal outcomes registered results twenty four pregnancies exposed anti tnf alpha conception trimester prior conception following paternal exposure two congenital malformations one infant diagnosed congenital diaphragmatic hernia obstructive megaureter mother exposed adalimumab conception trimester one foetus showed trisomy mother year old suspended etanercept weeks conception significant difference pregnancy foetal outcome two groups significant differences pregnancy foetal outcomes various groups treated different anti tnf alpha antagonists congenital malformations found connection paternal exposure conclusion study results suggest anti tnf alpha drugs could safe administered conception trimester following paternal exposure societe francaise rhumatologie published elsevier masson sas rights reserved
background igg galactose alpha galactose alpha gal highly abundant natural antibodies humans alpha gal specific ige cause special form meat allergy characterized severe systemic reactions consumption red meat investigated patients experienced reactions characterized alpha gal specific ige igg responses detail methods alpha gal specific ige determined immunocap ige reactivity meat extract bovine gamma globulin bgg assessed immunoblotting elisa respectively experiments sera pre incubated alpha gal protein deplete igg alpha gal specific igg individuals without meat allergy assessed elisa results immunoblots bgg frequently recognized meat protein binding ige igg bgg confirmed elisa completely abolished pre incubation alpha gal neither depletion autologous alpha gal specific igg addition alpha gal specific igg nonallergic individuals changed ige recognition bgg meat allergic patients meat allergic patients showed significantly higher alpha gal specific igg igg nonallergic individuals whereas latter showed significantly higher levels alpha gal specific igg conclusion patients delayed meat allergy display ige igg selectively recognize alpha gal epitope bgg enhanced alpha gal specific ige levels accompanied high levels alpha gal specific igg devoid ige blocking activity subclass distribution atypical food allergies distinct natural alpha gal igg responses nonallergic individuals
dermatophytosis superficial cutaneous fungal infection skin hair nails trichophyton tonsurans anthropophilic cosmopolitan dermatophyte frequently associated tinea capitis year old female presented non healing ulcers month duration left leg mimicking squamous cell carcinoma atypical mycobacterial infection skin biopsy taken preparation koh revealed plenty thin hyaline septate hyphae fungal culture sda without antibiotics showed whitish suede like fungal growth central furrows fungus identified trichophyton tonsurans antifungal treatment started patient improved drastically weeks treatment conclude cases non healing ulcers suspicion fungal infection must kept skin biopsy sent fungal culture
analytical solutions partial differential equation pde models describing reactive transport phenomena saturated porous media often used screening tools provide insight contaminant fate transport processes many practical modelling scenarios involve spatially variable coefficients spatially variable flow velocity spatially variable decay rate analytical models deal constant coefficients present framework constructing exact solutions pde models reactive transport approach relevant advection dominant problems based regular perturbation technique present description solution technique range one dimensional scenarios involving constant variable coefficients show solutions compare well numerical approximations general approach applies range initial conditions various forms instead simply documenting specific solutions particular cases present symbolic worksheet supplementary material enables solution evaluated different choices initial condition also discuss technique generalizes apply models coupled multispecies reactive transport well higher dimensional problems
populist radical right prr parties attracted anti migration voters claiming serve interests nationally defined groups recently several european prr parties shifted focus protecting traditional values protecting called modern western values including lesbian gay bisexual transgender rights study whether prr parties managed attract voters hold modern values contrast previous research position voters modern values necessary opponents nativist voters european social survey data linked elections demonstrate likelihood vote prr parties somewhat lower among lesbian gay rights people strong anti migration attitudes however effect differs across countries cases sexually modern nativists highest prr voting likelihoods directly related parties position modern family values party system alternative right wing parties present
background although scientific knowledge benefits probiotic use cystis fibrosis scarce expectative promising aim work analyze effect lactobacillus reuteri probiotic preparation versus placebo patients methods prospective double blind crossover placebo study carried patients two spanish hospitals patients randomized group months probiotic followed months placebo group months placebo followed months probiotic giqli gastrointestinal general health tests performed probiotic placebo intakes fat absorption coefficient calprotectin inflammatory interleukin quantification determined fecal samples total fecal dna obtained metagenomic pyrosequencing applied analyze microbiome composition stata software used statistical analyses results statistically significant improvement gastrointestinal health decrease calprotectin levels demonstrated patients probiotic exposure comparison placebo subjects reported good tolerance reuteri without secondary effects metagenomic analysis showed important dysbiosis gut microbiota associated high concentration proteobacteria probiotic intake followed reduction total bacterial density mostly due considerable reduction gamma proteobacteria phylum important increase microbial diversity higher representation firmicutes conclusions probiotics might ameliorate dysbiosis gut microbiota characterized high density proteobacterial organisms reuteri significantly decrease intestinal inflammation increase digestive comfort european cystic fibrosis society published elsevier rights reserved
signal flow graph nonlinear modeling method employed develop unified model parallel converter coupled inductors derivation large small signal steady state models unified signal flow graph demonstrated converter performance expressions steady state small signal characteristic transfer functions derived large signal model developed programmed tutsim simulator large signal responscs load supply disturbances obtained furthermore validate signal flow graph modelling large signal responses compared psim simulator results closely matching thus validating signal flow graph modelling
although extensive research suggests attention deficit hyperactivity disorder adhd conduct problems symptoms oppositional defiant disorder conduct disorder antisocial personality disorder contribute risk substance use symptoms increase risk substance use remains unclear given research indicates perceived peer tolerance perceived peer substance use affect substance use evaluated degree peer perception constructs mediated association adhd symptoms symptoms interaction share substance use alcohol use marijuana use illicit drug use participants college students female european american mean age years results indicated perceived peer use significantly mediated association adhd symptoms alcohol marijuana illicit drug use whereas perceived peer use mediated association symptoms alcohol use perceived peer tolerance significantly mediated association adhd symptoms marijuana use alcohol illicit drug use finally symptoms moderated indirect effect adhd symptoms alcohol use perceived peer tolerance low levels symptoms increases adhd symptoms corresponded increases perceived peer tolerance related increased alcohol use however high levels symptoms increases adhd symptoms corresponded decreases perceived peer tolerance associated decreased alcohol use implications findings discussed
lack longitudinal studies impedes understanding whether visual processing skills significantly influence reading performance present study assessed multi element processing mep visual processing task comprising non verbal stimuli predominantly related decoding sight word reading one hundred spanish pre reading children evaluated mep naming speed ran phonemic awareness letter knowledge early reading level measured first grade third grade four reading lists consisting short long high low frequency words administered results path analyses revealed controlling ran early reading level mep significant predictor reading long low frequency words result suggests transparent spanish orthography pre reading mep significantly linked future decoding skill first study provide empirical evidence pre reading mep predicts future reading elsevier inc rights reserved
parents interact environment important ways may impact ability parent children positively current study uses data age wave fragile families child wellbeing study investigate whether neighborhood processes community participation relate internal control whether three variables associated child maltreatment behaviors using structural equation modeling direct indirect effects environment neighborhood disorder social control social cohesion community participation child maltreatment tested mediating variable tested internal control results show neighborhood processes community participation associated child neglect physical child abuse psychological aggression associations driven effect internal control elsevier ltd rights reserved
development single factor experiments employed evaluate effect adding different matrix enhancers hmt ethanol glycerol drug skin development single factor experiments employed evaluate effect adding different matrix enhancers hmt ethanol glycerol drug skin permeation finally carbopol selected gel matrix methyl pyrrolidone nmp chosen enhancer relationship time steady accumulative percutaneous amount optimized hmt hydrogels absolute bioavailability hmt hydrogels showed pharmacokinetic study skin irritation observed hmt hydrogels skin irritation study pharmacodynamic study overactive bladder model induced pilocarpine rats significant effects hmt hydrogels inhibition urine output rat model last optimized hmt hydrogels displayed prolonged pharmacological responses hmt hydrogels effectively avoided metabolism difference enzyme bodies compared tolterodine tablets provided one single active compound plasma reduce variability two active compounds elucidate transdermal mechanism fourier transform infrared ftir spectroscopy differential scanning calorimeter dsc activation energy measurements used study transdermal routes changes stratum corneum drug release elsevier rights reserved
objective study urethral pressure variations whole filling phase among different groups patients material methods investigated consecutive patients january june patients recruited within routine practice continence clinic evaluated urodynamic exam according standards international continence society ics additional continuous measurement urethral pressure profile cupp done supine position patients genital prolapse grade well patients impaired cognitive function neurogenic disorders excluded bacteriuria time investigation excluded urine analysis urethral pressure changes higher cmh considered urethral instability results investigated patients clinically diagnosed oab syndrome stress urinary incontinence sui mixed oab sui incontinence prevalence urethral instability defined study mean delta patients oab cmho significantly higher groups pure stress cmho mixed urinary incontinence cmho conclusions etiology urethral instability unknown high prevalence among patients overactive bladder syndrome especially concomitant detrusor activity raise fair question direct diagnostic well treatment efforts
paper robust optimal fuzzy controller based pulse width modulation pwm technique proposed control laboratory parallel robot using inexpensive solenoid valves controller coefficients determined using modified cuckoo optimization algorithm objective function method considered results show position tracking robot less force efficiency regarding results experimental tests control strategy valves indicates good performance maximum value rms error circular path increasing force system furthermore results show superiority optimal fuzzy controller compared optimal pid controller tracking paths different conditions uncertainties isa published elsevier ltd rights reserved
field parallel computing experienced increase number computing nodes allowing broader applications including computations irregular features parallel programming languages handle object data structures offer marshaling unmarshaling mechanisms transpose manage data elements across computing nodes research distributed collections conducted study proposes distributed collection library handle multiple collections object elements change distributions maintaining associativity elements library implemented object oriented parallel programming language authors assume pairs associative collections vehicles streets traffic simulation many vehicles concentrated streets assigned certain computing nodes streets moved nodes authors library assists programmer easily distributing associative collections computing nodes collectively relocating elements maintaining data sharing relationship among associative elements programmer describe associativity objects using declarative procedural methods show preliminary performance evaluation library linux cluster computer
tangram help hurt task laboratory based measure designed simultaneously assess helpful hurtful behavior across five studies provide evidence establishes convergent discriminant validity tangram help hurt task cross sectional meta analytic evidence finds consistently significant associations helpful hurtful scores tangram task prosocial aggressive personality traits experimental evidence reveals situational primes known induce aggressive prosocial behavior significantly influence helpful hurtful scores tangram help hurt task additionally motivation items studies indicate tangram choices indeed associated intent helping hurting discuss advantages limitations tangram help hurt task relative established measures helpful hurtful behavior wiley periodicals inc
adaptive like expansions natural killer cell subsets known occur response human cytomegalovirus cmv infection expansions typically made nkgc cells particular killer cell immunoglobulin like receptor kir expression patterns cell expansion patterns also seen patients viral hepatitis infection yet known viral hepatitis infection promotes appearance expansions effects solely attributed underlying cmv infection sizeable cohorts cmv seropositive hepatitis virus hbv hepatitis virus hcv hepatitis delta virus hdv infected patients analyzed cells expression nkga nkgc inhibitory kirs assess appearance cell expansions characteristic seen cmv seropositive healthy individuals adaptive like cell expansions observed viral hepatitis patients strongly associated cmv seropositivity number subjects expansions differ cmv seropositive viral hepatitis patients corresponding healthy controls hence conclude adaptive like cell expansions observed hbv hcv hdv infected individuals caused chronic hepatitis infections per rather consequence underlying cmv infection
buildings need energy including heat electricity provided solar systems solar thermal photovoltaic systems absorb solar energy supply heat electricity buildings respectively however urban residential buildings limited available area makes installation solar thermal collectors photovoltaic modules together impossible hybrid photovoltaic thermal system simultaneously generate heat electricity deemed quite suitable urban residential buildings application yet rural house china available area installation solar collectors large daily domestic hot water demand rural family generally exceeded hybrid photovoltaic thermal collectors installed whole available area lead overproduction thermal energy especially summer moreover buildings requiring heat electricity different different regions different seasons paper simulation models solar thermal photovoltaic hybrid photovoltaic thermal systems presented experiments also performed validate simulation results using validated models performances three solar systems residential applications predicted energy comparison three solar systems used hongkong lhasa shanghai beijing china respectively also studied results show urban residential building limited available installation space hybrid photovoltaic thermal system may largest potential reducing energy consumption among solar thermal photovoltaic hybrid photovoltaic thermal systems rural house large available area system photovoltaic hybrid photovoltaic thermal modules obtained net annual electricity output installation area hybrid photovoltaic thermal collectors mainly depended hot water load building elsevier ltd rights reserved
paper presents mechatronic system approach improvement part straightness accuracy rough cutting wire electrical discharge machining wire edm mechatronic system design integrated active wire feed apparatus microcontroller based wire tension control system novel wire transport system providing smooth wire transport constant wire tension value active wire feed apparatus first devised reduce inertial effect wire spool wire transport system proportional integral derivative pid controller used implement real time wire tension control wire transport system compared typical wire transport system steady state error wire tension control reduced half using newly developed system pulse train analysis proportion normal sparks total sparks defined normal spark ratio used monitor spark gap condition well indication evaluating machining speed part straightness accuracy experimental results show part straightness accuracy significantly improved newly developed wire transport system along optimum machining settings
non communicable diseases cardiovascular disease cvd obesity cancer pulmonary disease diabetes high global health concern health costs risk factors cvd hypertension htn mounting unrelenting example estimated direct indirect costs due htn amounted billion projections six fold increases importance low cost nonpharmacological interventions involving collaborative teams health care professionals critical junction certainly data supported research including clinical trials healthy living interventions support deploying health education nutrition smoking cessation physical activity preventing cvd risk htn exercise training blood pressure control shown effective integral component management however less known optimization modalities nutrition lifestyle tracking modern era technologies bring equation new research methods may need consider collaborate collect data using teams researchers interacting community centers school systems traditional health care practices review discuss present known research support modern era healthy living medicine data may integrated venues support health lifestyle community schools work place elsevier inc rights reserved
accumulation deposition amyloid beta beta brain represent early perhaps necessary step pathogenesis alzheimer disease beta accumulation leads formation beta aggregates may directly indirectly lead eventual neurodegeneration beta production accelerated many familial forms early onset increasing evidence indicates impaired clearance beta evident late onset uncover mechanisms underlying impaired beta clearance examined role low density lipoprotein receptor related protein lrp astrocytes although lrp shown play critical roles brain beta metabolism neurons vascular mural cells role astrocytes abundant cell type brain responsible maintaining neuronal homeostasis remains unclear show astrocytic lrp plays critical role brain beta clearance lrp knockdown primary astrocytes resulted decreased cellular beta uptake degradation addition silencing lrp astrocytes led downregulation several major beta degrading enzymes including matrix metalloproteases mmp mmp insulin degrading enzyme important conditional knock lrp gene astrocytes background app mice impaired brain beta clearance exacerbated beta accumulation accelerated amyloid plaque deposition without affecting production together results demonstrate astrocytic lrp plays important role beta metabolism restoring lrp expression function brain could effective strategy facilitate beta clearance counter amyloid pathology
given set uncertain points real line represented onedimensional probability density function consider problem building data structures answer range queries following three types query interval top query find point lies highest probability top query given integer part query return points lie highest probabilities threshold query given threshold part query return points lie probabilities least present data structures range queries linear nearly linear space efficient query time elsevier rights reserved
present logic reasoning attribute dependencies data involving degrees degree object red degree two objects similar dependencies form double dagger interpreted two ways first data tables entries representing degrees objects rows attributes columns second database tables domain equipped similarity relation assume degrees form scale equipped operations representing many valued logical connectives degrees algebra degrees becomes two element boolean algebra two interpretations become well known dependencies boolean data functional dependencies relational databases setting general scales obtain new kind dependencies naturally arising degrees validity degrees entailment related logical concepts deduction rules proposed logic inspired armstrong rules make possible infer dependencies degrees degrees provability provide soundness completeness theorem setting asserting degrees entailment coincide degrees provability prove independence deduction rules present observations
equivalence classes formed names time periods characteristics three stages prenatal development students classroom baseline relations classes established group basis students classroom use feedback enhanced clicker training thereafter class formation tracked individual basis quickly administered sorting test classes emerged immediately students single minute class session thus many students showed immediate formation equivalence classes training done group basis feedback enhanced form clicker training sorting test used track class formation also considered likely mechanisms could account learning baseline relations individual participants clicker training finally considered feasibility using clickers sorting protocol implement equivalence based instruction
skin biomechanics become emerging area research interest covers wide range applications product design surgery animation materials engineering based literatures silicone rubber one best candidate materials exhibit desirable skin characteristics thus making right material skin substitute nonetheless specific standard used measure mechanical properties deformation behaviour synthetic skin paper first time aims assess two standard testing methods silicone rubber work carried stages involving uniaxial testing quantifying material constants using matlab programme mechanical tests conducted types materials different grades silicone rubber using uniaxial tensile test two different standards astm astm raw testing data load extension input house developed matlab programme compute plot stress stretch value based neo hookean model based statistical analysis testing data found valid since sample variance found less neo hookean constants found astm astm material astm astm material revealing difference material material respectively conclusion significant difference quantified material constants suggests dedicated testing standard must used
long term arsenic exposure results atherosclerosis cancers along aberrant immune responses animal based epidemiological studies indicate arsenic exposure increases susceptibility viral bacterial infections study aimed assess whether arsenic exposure associated development fungal infection substantially attributed cause aberrant immunity based two well established cohorts two basins southwestern high arsenic area northeastern low arsenic area taiwan respectively arsenic exposure well water estimated using hplc icp fungal infections defined via clinical mycological assessments pcr fungal rrna nail samples individuals cohort cumulative arsenic exposure years higher risk developing fungal infections adjusting diabetes occupation cohort female sex alcohol consumption chronic kidney diseases associated toenail infections contrast fingernail infections highly associated arsenic exposure dose dependent manner first report palmar plantar hyperkeratosis upon low arsenic exposure individuals respectively first large scale study showing arsenic exposure associated fungal infections dose dependent manner elsevier ltd rights reserved
objectives age bone mineral density bmd relevant determinants public health authorities govern management osteoporosis objectives study determine age related prevalence osteopenia osteoporosis according criteria fragility fractures middle aged older women methods women years referred menopause osteoporosis outpatient clinic bmd measurements assessed patient characteristics bmd previous fragility fractures hip distal forearm vertebrae records initial consultations used data analysis results women mean age years referred clinic bmd testing total population showed normal osteopenic osteoporotic bmd fragility fractures reported patients non vertebral fractures namely distal forearm hip fractures patients non vertebral fractures years conclusion prevalence osteoporosis fragility fractures middle aged women years hitherto recognized measuring bmd alone sufficient identify patients risk fractures supplemental screening clinical risk factors already perimenopause may advantageous
study investigates managers enhance knowledge management among front line hotel employees individual level affecting employee goal orientations supervisory orientations study found significant influence supervisory orientations employee goal orientation positive effect employee learning goal orientation also significant however effect performance goal orientation insignificant results also support indirect positive effect supervisory end result capability orientations mediation goal orientation main contribution study identification indirect effect supervisory orientation mediation employee goal orientation study links three separate concepts supervisory orientation employee goal orientation single model first time furthermore concept supervisory orientations discussed existing hospitality literature elsevier ltd rights reserved
robust sparse least mean mixture norm lmmn algorithm proposed performance appraised context estimating broadband multi path wireless channel proposed algorithm implemented via integrating correntropy induced metric cim penalty conventional lmmn algorithm modify basic cost function denoted cim based lmmn cim lmmn algorithm proposed cim lmmn algorithm derived detail within kernel framework updating equation cim lmmn provide zero attractor attract non dominant channel coefficients zeros also gives tradeoff sparsity estimation misalignment moreover channel estimation behavior investigated broadband sparse multi path wireless channel simulation results compared least mean square fourth lms least mean square lms least mean fourth lmf recently developed sparse channel estimation algorithms channel estimation performance obtained designated sparse channel estimation demonstrates cim lmmn algorithm outperforms recently developed sparse lmmn algorithms relevant sparse channel estimation algorithms results see cim lmmn algorithm robust superior mentioned algorithms terms convergence speed rate channel estimation misalignment estimating sparse channel
paper describes whole procedures determine ice induced global loads ship using measured full scale data accordance method proposed canadian hydraulics centre national research council canada ship motions degrees freedom dof found processing commercial sensor signals named motion pak assumption rigid body motion linear accelerations well angular rates measured motion pak data eliminate noise measured data staircase signals due resolution sensor band pass filter passes frequencies cubic spline interpolation resampling applied dof motions computed integrating differentiating filtered signals added mass damping force ship computed dimensional panel method assumption zero frequency coefficients hydrodynamic hydrostatic data well dof motion data obtained global ice loads computed solving fully coupled dof equations motion full scale data acquired araon rammed old ice floes high arctic estimated ice impact forces two representative events showed ship operated heavy ice conditions copyright production hosting elsevier behalf society naval architects korea
background dengue considered one world important mosquito borne diseases micrornas mirnas small non coding single stranded rnas play important role regulation gene expression eukaryotes although mirnas possess antiviral activity many mammalian infecting viruses involvement dengue virus denv replication remains poorly understood objective determine role mir mir denv infection examine whether denv infection alters expression mirnas methods used bioinformatics tools explore relationship denv cellular mirnas overexpressed mir mir vero cells examine role denv replication using flow cytometry reverse transcriptase quantitative polymerase chain reaction qpcr western blotting findings found several cellular mirnas target conserved region within untranslated region utr genome four denv serotypes found overexpression mir mir inhibits infection denv denv furthermore observed denv rna might involved downregulation endogenous mir mir conclusion study identifies mir mir two possible restriction host factors denv infection however studies needed directly verify whether mir mir anti denv effect vivo
thrombin generation potential vitro measure capacity individual generate thrombin recognized reflection hypo hypercoagulable status measurement vivo thrombin activity however may clinical significance evaluated new assay vivo thrombin activity compared vitro thrombin generation potential patients hemophilia oral anticoagulation atrial fibrillation subjects active cancer healthy volunteers thrombin activity measured commercially available oligonucleotide enzyme capture assay argatroban stabilized plasma samples thrombin generation potential determined commercially available assay citrated plasma thrombin activity detected patients mean patients thrombin activity present cancer patients thrombin activity detected patients range particularly increased patients vessel invasive tumors patients thrombin activity measureable two patients recent hematoma recent ischemic stroke thrombin activity detected four patients hemophilia range received factor viii infusion day thrombin activity correlate parameters thrombin generation potential patients acute procoagulatory states clotting factor replacement elevated vivo thrombin activity however unrelated vitro thrombin generation potential
objectives acquired somatic mutation janus kinase jak associated various myeloproliferative neoplasms mpn allele specific real time polymerase chain reaction widely adopted detect mutation however utility low positive results well understood aim study investigate clinical significance low positivity jak materials methods retrospective analysis performed jak mutation tests performed using jak mutaquant kit ipsogen molecular laboratories major academic medical centers cases low positive jak defined mutant allele documented chart review performed clinical correlation results total jak tests performed forty five cases yielded low jak positivity average majority eight cases history mpn remaining cases related reactive conditions without clonal disease data indicate low positivity jak seen mpn well reactive conditions conclusions interpretation jak status performed simply following arbitrary cutoff low positivity jak reported correlation clinical information warranted proper interpretation
child protection continues pressing social problem robust relevant research essential order ensure scale nature child maltreatment understood preventative protective measures effective paper reports selected results mapping review research conducted published january december purpose review twofold develop typology child protection research use typology describe features patterns empirical research undertaken recently order inform future research agenda paper reports maltreatment types substantive topics research designs used within empirical research published academic journals identifies number challenges field including need conceptual clarity regarding types abuse greater methodological diversity shift focus response prevention child maltreatment importance national strategic agenda also emphasised copyright john wiley sons ltd
autoimmune diseases associated pathological pain development autoimmune diseases pathological pain include complex regional pain syndrome rheumatoid arthritis guillian barre syndrome name present review explores research linking immune system development pathological pain autoimmune diseases pathological pain linked cell activation release cytokines activated microglia dorsal horn spinal cord new research role autoantibodies autoimmunity generated insights potential mechanisms pain associated autoimmune disease autoantibodies may act various mechanisms autoimmune disorders include alteration neuronal excitability via specific antigens voltage gated potassium channel complexes mediating bone destruction rheumatoid arthritis although research must done understand better role autoantibodies autoimmune disease related pain may promising area research new analgesic therapeutic targets wiley periodicals inc
electric vehicles hybrid electric vehicles hev require electric motor high power density high efficiency wide constant power operating region flux weakening capability three phase interior permanent magnet synchronous motors ipmsms meet criteria hence used commercial electrified vehicles work presents analysis control system design simulation maximum torque per ampere mtpa control strategy two axes rotor reference frame control applied custom designed three phase traction ipmsm electric scooter direct drive base speed beyond base speed flux weakening control taking care machine voltage current constraints novel way dynamically change limits axis axis reference voltages yet remaining within machine voltage constraints presented paper order exploit large flux weakening range effectively
paper summarizes reviews research electromagnetic interference emi shielding intrinsically conducting polymers icps mainly polyaniline pani polypyrrole ppy composites various frequency ranges icps new alternative candidates emi shielding applications due lightweight corrosion resistance ease processing tunable conductivities compared typical metals importantly dominant shielding characteristic absorption reflection metals render icps promising materials applications requiring high emi shielding effectiveness also shielding absorption stealth technology copyright john wiley sons ltd
regenerative braking one effective deceleration control methods case electric hybrid vehicles properly controlled regenerative braking force electric motor brings better braking safety shorter braking distance less depreciation brakes accompanied hydraulic braking modules brake pedal pressed electric motor treated generator produce negative torque scenario produced energy either dissipated used charge batteries paper based registered brake strength braking force calculated accordingly employing braking torque distribution strategy regenerative braking torque hydraulic braking torque proper braking torques determined optimal slip ratio reached adjusting braking torques anti lock regenerative braking strategy proposed attain anti slip control negative accelerations performance proposed system evaluated using simulations attained simulation results show optimal braking characteristics achievable variety conditions using proposed method
introductioninterpersonal hypersensitivity often observed schizophrenia associated psychopathological deficits schizophrenia investigated dysfunctions interpersonal information processing schizophrenia conscious subconscious levels methodsthe experiment included schizophrenia patients healthy controls continuous flashing suppression approach based binocular rivalry employed included two modes invisible subconscious visible conscious accuracy reaction time gabor patch direction detection task assessed three types stimuli modes images person type images two three noncommunicating persons type images three communicating individuals type resultsin visible mode accuracy gabor patch direction detection task case group significantly lower control group third type stimuli invisible mode however accuracy higher case group control group response time difference gabor patch direction detection task third type images invisible mode negatively correlated duration illness discussionthese findings suggest schizophrenia patients exhibit attentional bias interpersonal interaction behaviors conscious subliminal levels toward opposite directions findings shed light subconscious deficits paranoid symptom schizophrenia
hazardous environments industry sector high chemical usage give high risks safety workers risks reduced designing robotic hand able replace human works industry purpose robotic hand needs higher performance accuracy stability consistency however current robotic hand industry flexible means used different tasks therefore multipurpose robotic hand developed paper objectives research design develop pid controller improving performances robotic hand system experimental results prove pid controller shows good performances steady state error less degrees input reference degrees respectively
article presents rail rail cmos operational amplifier constant offers simple topology low power consumption uses simplified shift level circuit input self biased folded cascode intermediate stage class push pull output stage provide large gain amplifier implemented ibm cmos technology works power supply voltage consumes offers gain comparison work literature reveal large gain low power rail rail amplifier suitable many applications
geosynthetic tubes placed soft ground ground settlement large enough influence design performance geosynthetic tubes existing method model ground deformation design geosynthetic tubes use winkler model paper analytical solution proposed calculate impermeable geosynthetic tubes resting deformable foundation soil proposed analytical method adopts consolidation relationship log curve describe approximately stress strain behavior soil vertical surcharge pressure distribution within soil mass calculated using boussinesq solution numerical analyses also carried using flac evaluate accuracy proposed method results analytical method agree well numerical analysis elsevier ltd rights reserved
solar energy clean renewable energy phase change material pcm used buildings store surplus heat release needed save energy winter paper establishes new model pcm floor coupled solar water heating system pfcss module pfcss building established trnsys module validated full scale experiment two experiment buildings reference building pfcss building set ninghe county tianjin china experiment lasted days february two mathematical methods mre mean relative error bland altman consistency analysis used evaluate accuracy model comparison experiment data simulation data pfcss building mre result bland altman consistency analysis confidence interval model control building ordinary radiant floor set compare differences temperature performance relation pfcss building pfcss building temperature fluctuation smaller heating process longer control building indoor temperature maintained degrees pfcss building save energy consumption compared control building based two existing models influences pcm thermal physical parameters indoor air temperature analyzed simulation elsevier rights reserved
controlling microbial activity primary concern management large volumes wastewater produced water generated high volume hydraulic fracturing study analyzed transcriptional activity metatranscriptomes three produced water samples marcellus shale goal study describe active metabolic pathways industrial concern produced water management reuse improve understanding produced water microbial activity metatranscriptome analysis revealed active biofilm formation sulfide production stress management mechanisms produced water microbial communities biofilm formation sulfate reduction pathways identified samples genes related diverse array stress response mechanisms also identified implications biocide efficacy additionally active expression methanogenesis pathway identified sample produced water collected prior holding pond storage active microbial community identified metatranscriptome analysis markedly different community composition identified rrna sequencing highlighting value evaluating active microbial fraction assessments produced water biofouling potential evaluation biocide application strategies results indicate biofouling corrosive microbial processes active produced water taken consideration designing produced water reuse strategies
describing user activity plays essential role ambient intelligence work review different methods human activity recognition classified data driven knowledge based techniques focus context ontologies whose ultimate goal tracking human behavior studying upper domain ontologies useful human activity representation inference establish evaluation criterion assess suitability different candidate ontologies purpose result missing features relevant modeling daily human behaviors identified future challenges
hypo hyperthyroidism effects brain structure function well cognitive processes including memory however little known influence thyroid hormones brain perfusion relationship perfusion changes cognition present study aimed demonstrate effect short term experimental hyperthyroidism brain perfusion healthy volunteers assess whether perfusion changes present related cognitive performance known interaction exists brain perfusion cerebral oxygen consumption rate considered neural activation increases cerebral regional perfusion rate brain areas associated memory measuring cerebral blood flow may therefore represent proxy neural activity therefore arterial spin labelling asl measurements conducted later analysed evaluate brain perfusion healthy men ingesting thyroid hormones weeks psychological tests concerning memory performed time points results correlated imaging results hyperthyroid condition perfusion increased posterior cerebellum regions connected cerebral networks associated cognitive control visual cortex compared euthyroid condition addition perfusion changes positively correlated changes performance german version auditory verbal learning task avlt verbaler lern und merkfahigkeits test vlmt cerebellar perfusion function therefore appears modulated thyroid hormones likely cerebellum hosts high number thyroid hormone receptors
mutually coupling lines transmission signal dispersively propagated crosstalk coupling lines shows complex propagation characteristics caused reciprocal reflections usually differential equation integral equation applied analyze solutions transmission lines paper propose different analytical method propagation characteristics signal crosstalk noise setting crosstalk coupling line sectionally divided digital transmission network using signal flow graph difference equation propagation characteristics frequency domain space domain time domain mutually coupling lines obtained verify validity method analyze complex propagation problems first study crosstalk characteristics twisted pair cable via third circuit unidirectional coupling subsequently analyze coupling theory bidirectional coupling lines
odum suggested set rules simulating dynamics emergy flow dynamic emergy accounting dea offers capability investigate emergy transformity storage energy increases decreases time according inflows outflows emergy energy however odum original rules cumbersome appear violate fundamental emergy algebra aim paper advance dea simplifying equations rules needed simultaneously simulate energy material emergy transformity odum statements mini models computer programming code reviewed explore intentions emergy transformity stored energy increased decreased time simplifications proposed compared odum original rules using single tank simulation model emtank new simplified rule dea change emergy stored balance emergy input emergy output regardless whether stored energy increasing decreasing changing simplifications included removing logic statement requires emergy accumulation stop storage near climax disallowing emergy lost via heat sink requiring emergy exported storage one important aspects simplification allows transformity storage decline may significant philosophical shift many emergy analysts streamlining mathematics dea widens opportunities simulating emergy various systems range complexities advance science emergy evaluation elsevier rights reserved
shape memory alloys sma possess sensing actuating functions due shape memory effect pseudo elasticity high damping capability remarkable properties combining sma materials create intelligent smart composites epoxy resin composites filled alloys wires fabricated mechanical properties investigated study stress strain relationships composite embedded sma wires presented paper illustrates influence sma wires upon changes mechanical behaviour composite plate sma components firstly secondly actuating ability reliability shape memory alloy hybrid composites
using dedicated stereo camera systems structured light well known method measuring shape large surfaces however problem trivial high accuracy range tens microns needed many error sources need handled carefully order obtain high quality results study present measurement method based low cost camera illumination solutions combined high precision image analysis new approach camera calibration reconstruction setup consists two ordinary digital cameras gobo projector structured light source matrix dots projected onto target area two cameras capture images projected pattern object images processed advanced subpixel resolution algorithms prior application reconstruction technique strength method lays different approach calibration reconstruction high precision image analysis algorithms using pitch pattern light dots method capable reconstructing shape surfaces precision sigma repeatability measurements volume hardware cost similar available advanced measurement techniques expanded uncertainty confidence level estimated largest uncertainty contribution coming absolute length metal ruler used reference
topological method obtaining jacobian hessian matrices active networks presented based replacement investigated network using nullor equivalent circuit representation circuit passive part chan mai signal flow graph cmsfg jacobian hessian matrix elements nullor network obtained means dependent variables two four isomorphic cmsfgs respectively two examples illustrate proposed method
articular bone erosion rheumatoid arthritis mediated interaction inflammation pathways regulating bone metabolism inflammation promotes osteoclastogenesis also inhibits osteoblast function contributing persistence erosions micrornas mirnas important regulators skeletal remodeling play role pathogenesis therefore determined expression mirnas inflamed synovial tissue role play pathways regulating osteoblast osteoclast function using serum transfer mouse model cbl mice performed fluidigm high throughput qpcr based screening mirnas nonarthritic arthritic mice global gene expression profiling also performed affymetrix microarrays synovial samples mirna mrna expression profiles subjected comparative bioinformatics total upregulated genes downregulated genes identified predicted targets mirnas reciprocal expression changes gene ontology analysis genes revealed significant enrichment skeletal pathways mirnas whose expression significantly changed nonarthritic arthritic mice identified targets inhibit promote bone formation mirnas predicted target wnt bmp signaling pathway components validated mirna array findings demonstrated secretion mir exosomes upregulated synovial fibroblasts treated proinflammatory cytokine tnf overexpression mir suppressed calvarial osteoblast differentiation mineralization vitro results suggest mirnas derived inflamed synovial tissues may regulate signaling pathways erosion sites affect bone loss potentially also compensatory bone formation american society bone mineral research
dislocation topological defect atoms position crystalline structure plays important role theory plasticity stability strength materials melting processes paper report experimental numerical study interaction dislocation compressional solitary wave strongly coupled plasma crystals complex plasmas consist micrometer sized spheres immersed ordinary ion electron plasma exist solid liquid gaseous states model systems study dynamic phenomena
objective temperate latitudes population suffer winter depression winter mood difficulties tend increase may alleviated bright light therapy unlike indoor workers outdoor workers exposed therapeutic levels sunlight winter hypothesized outdoor work may protect mood difficulties depression method studied hypothesis among civil servants arhus denmark participated survey january february mental symptoms defined common case category broke two parts depression mood difficulties depression total controls also sampled study population participants reported extent outdoor work results confounder adjusted odds ratio mood difficulties showed decreasing trend increasing hours outdoor work borderline statistical significance confidence interval working outdoors hours day effect suggested depression conclusion study limited cross sectional design low statistical power nevertheless suggests outdoor work winter may protect mood difficulties finding holds true may significant impact workers health well public health general therefore studies recommended
rainwater harvesting rwh practice growing importance united kingdom particularly southeast england water availability per person even less many mediterranean countries although huge amount rainfall north west england wales water resources southeast east england pressure due growing population changing climate therefore rwh becomes particularly important reduce dependence mains water supply present study suitable areas rwh identified using geographic information system based decision support system dss remote sensing dss undertakes combination thematic layers rainfall surplus slope curve number land cover use soil texture spatial extents suitability areas rwh identified using multi criteria evaluation spatial distribution suitability map shows excellent suitable areas rwh northwest less suitable areas northern eastern parts average suitability rwh found area excellent good moderate whilst unsuitable poor respectively use number rwh sites excellent areas recommended ensure successful implementation rwh systems
polymer based materials emerging potential substitute metallic structures oil gas industry context fiber reinforced polymer frp piping one promising application important area research pertaining frp piping connection pipe sections challenges associated joining frp tubular sections often considerable limits widespread industrial application adhesive bonding emerging promising technique join tubular frp structures ability maintain undamaged fiber architecture major advantage adhesive bonding technology present study strength materials well fracture mechanics approach employed conjunction finite element method investigate scaling effects adhesively bonded tubular sections found scaling effects joined frp pipe may significant certain composite material configurations analysis indicated shift region failure pipe structure pure adhesive cohesive failure increasing pipe diameter
sio coated feo nanoparticles feo sio nps successfully synthesized using ultrasound order extract dna cancer tissues application diagnostics core diameter feo nanoparticles synthesized precipitation reaction substrates nhoh precipitant coated thin layer amorphous silica modified stober method sio coating using alkaline hydrolysis tetraethyl orthosilicate ethanol water mixture accelerated presence khz ultrasound resulting nps different sizes version version version saturation magnetization values emu emu emu respectively among three feo sio nps versions nps allowed extraction dnas formalin fixed paraffin embedded ffpe tissues nasopharyngeal carcinoma patients highest recovery good purity extracted dnas could used templates downstream amplification sequencing specifically braf cancer biomarker gene using polymerase chain reaction pcr well detection pathogenic epstein barr virus ebv human papilloma virus hpv using real time pcr dna extraction recoveries ebv hpv using feo sio nps significantly better using commercialized feo sio microbeads indicated lower threshold cycles fluorescent signals including fluorescein amidite fam dye representative ebv infection hexachlorofluorescein hex dye representative beta globin internal control sybr green dye representative hpv infection tested clinical samples patients nasopharyngeal carcinoma npc
relations parental warmth self conscious emotions forgiveness investigated university students completed self report questionnaires online university sponsored website questionnaires contained measures five constructs parental warmth empathy shame self forgiveness interpersonal forgiveness results authors concluded interpersonal forgiveness self forgiveness predicted parental warmth empathy shame empathy mediated relation parental warmth interpersonal forgiveness self forgiveness parental warmth self conscious emotions important prediction interpersonal forgiveness self forgiveness
rail rail cmos operational amplifier operating weak inversion regime order amplify output signal air pressure sensor presented two main parts asic beta multiplier current source two stage amplifier layout drawn considering matching techniques chip fabricated characterized measured
mechanical electrical analogous circuit models widely used electromechanical system design represent function coupled electrical mechanical system using equivalent electrical system research uses electrical circuits establish discussion simple active vibration control principles using two scenarios active vibration isolation system active dynamic vibration absorber dva using voice coil motor vcm actuator active control laws gain scheduling intuitively explained using circuit analysis techniques active vibration control approaches typically constraint electrical power requirements electrical analogous fast approach specifying power requirements experimental test platform based vibration shaker provides based excitation required single degree freedom dof vibration model study
objective several previous studies demonstrated comorbidities secondary causes physical inactivity osteoporosis may cause recurrence benign paroxysmal positional vertigo bppv however also controversy clinical course cause recurrent bppv rbppv identified clinical features associated factors including decreased bone mineral density recurrence bppv methods total patients idiopathic bppv diagnosed otolaryngology clinics seoul national university boramae medical center enrolled medical data patients reviewed retrospectively recurrent bppv defined recurrence bppv least month symptom free interval following previous successful treatment results bppv patients classified rbppv among showed changes involved semicircular canals showed multiple semicircular canal involvement rbppv common patients comorbidities involved semicircular canals showed statistically significant difference according recurrence bppv mean symptom free interval rbppv group varied mean months however bppv recurrence occurred within months bone mineral density dual energy ray absorptiometry dexa markedly decreased bppv patients versus normal controls significant differences according bppv recurrence conclusion incidence rbppv idiopathic bppv patients present study mean period recurrence symptom free interval months patients showed recurrence within years first attack bppv furthermore patients suffered rbppv different kind type canal semicircular canal initial bppv attack comorbidities age gender involved semicircular canal might correlated bppv recurrence decreased bone mineral density show significant association bppv recurrence showed significant relation bppv occurrence elsevier ireland ltd rights reserved
connected dominating set cds problem well studied hard problem many important applications dorn algorithmica introduce branch decomposition based algorithm design technique hard problems planar graphs give algorithm dpbf algorithm solves planar cds problem time time conventional method fast matrix multiplication dynamic programming step algorithm respectively show dpbf algorithm solves planar cds problem time conventional method time fast matrix multiplication graph let branchwidth connected dominating number prove result planar cds problem admits time fixed parameter algorithm report computational study results practical performance dpbf algorithm show size instances solved algorithm mainly depends branchwidth instances coinciding theoretical analysis graphs small moderate branchwidth cds problem instances size thousands edges solved practical time memory space
carbonylation found irreversible post translational modification considered biomarker oxidative stress plays major role orchestrating various biological processes also associated diseases alzheimer disease diabetes parkinson disease however since experimental technologies costly time consuming detect carbonylation sites proteins accurate computational method predicting carbonylation sites urgent issue useful drug development study novel computational tool termed predcar site developed predict protein carbonylation sites incorporating sequence coupled information general pseudo amino acid composition balancing effect skewed training dataset different error costs method constructing predictor using support vector machine classifier predcar site predictor achieves average auc area curve score predicting carbonylation sites respectively experimental results along auc found average complete runs fold cross validation results indicate significantly better performance existing predictors published elsevier inc rights reserved
genetic factors early life adversity play major roles etiology schizophrenia previous studies indicated social isolation early postnatal development leads several lasting abnormal behavioral pathophysiological features resembling core symptoms human neuropsychiatric disorders mice glutamate dopamine hypotheses tightly linked development schizophrenia cross talk glutamate methyl aspartate acid receptors dopamine receptors associated histidine triad nucleotide binding protein hint correlated diverse psychiatric disorders examined effects schizophrenia like behavior used enzyme linked immunosorbent assays investigate expression levels hint subunit methyl aspartate acid receptor dopamine type receptor mice found leads series schizophrenia related deficits social withdrawal anxiety disorder cognitive impairments sensorimotor gating disturbances abnormal phenotypes paralleled changes hint may considered robust model effects early life stress schizophrenia related behaviors mice potential interactions among hint may underlie behavioral deficits induced copyright author published wolters kluwer health inc
gender identities family roles relationships important controversial contested place british asylum system drawing experience refused asylum seeker call martin article considers various ways family arose long course asylum claim loss parents falling love creating new family ties martin narrative experiences immigration system realities aftermath prison immigration detention article considers politics tensions hurdles family ties asylum seekers facing forced removal
sparse matrix vector multiplication spmv important issue scientific computing engineering applications performance spmv improved using parallel computing implementation optimization spmv gpu research hotspots due irregularities sparse matrices use single compression format satisfactory hybrid storage format expand range adaptation compression algorithms however imbalance non zero elements parallel computing capability gpu fully utilized parallel computing capability cpu also rising due increased number cores cpu however gpu computing cpu controls process instead contributing computational work leads utilization computing power cpu due characteristics sparse matrices data split two parts using hybrid storage format allocated cpu gpu simultaneous computing order take full advantage computing resources cpu gpu cpu gpu heterogeneous computing model adopted paper improve performance spmv analysis characteristics cpu gpu optimization strategy sparse matrix partitioning using distribution function proposed improve computing performance spmv heterogeneous computing platform experimental results two test machines demonstrate noticeable performance improvement elsevier inc rights reserved
particle swarm optimization pso heuristic optimization algorithm commonly used tuning pid type controllers paper pso applied control gain tuning position domain pid controller order improve contour tracking performances linear nonlinear contours serial multi dof robotic manipulator new fitness function proposed gain tuning based statistics contour error pre existed fitness functions also applied optimization process followed comparison studies pso tuning technique demonstrated effectiveness position domain controllers time domain controllers results quite satisfying low contour errors linear nonlinear contours proposed fitness function proved par pre existed fitness functions
allogeneic transplantation potentially curative strategy myelofibrosis even era new drugs far mitigate symptoms choice proceed allogeneic transplantation based several variables including age disease phase degree splenomegaly donor availability comorbidities iron overload factors along conditioning regimen time transplantation may influence outcome asct report patients affected myelofibrosis median age years range receiving treosulfan fludarabine based reduced toxicity conditioning patients pts received stem cell transplantation hla identical matched unrelated donor pts complete myeloablation followed engraftment evaluated pts donor chimerism month cases reduction splenomegaly reduction resolution bone marrow fibrosis observed median follow months range year probability overall survival disease free survival respectively cumulative incidence non relapse mortality years causes non relapse mortality infection gvhd haemorrhage conclude treosulfan fludarabine based conditioning potent myeloablative anti disease activity although non relapse mortality remains high challenging clinical setting copyright john wiley sons ltd
underwater applications manufacture sonar autonomous underwater vehicles auv large areas piezoelectric materials good electromechanical properties often needed piezoelectric single crystals typically compositions pmn pzn high performance materials high yields difficult manufacture large areas maintaining homogeneous properties study behavior piezoelectric single crystals conducted use finite element code atila developed isen collaboration french ministry defense results confirm good fit models experimental results phase optimization
education nurses republic croatia developed result compliance education european union implementation nursing research leads growth whole profession however prejudice nursing profession still present therefore necessary explore attitudes general population population nurses nursing profession order discover causes prejudices act therefore aim paper present transcultural adaptation validation nursing image questionnaire created toth associates questionnaire includes items measures individual looks roles values professional activities nurses conducted part preliminary study culturally adapted final study included students enrolled first year full time parttime nursing study questionnaire completed students toth associates assumed attitude toward nursing expressed sum responses items would mean factor structure high item intercorrelation also split questionnaire five thematic units results showed contrary expectations intercorrelations items extremely low following completion factor analysis satisfactory construct validity established obtained results concluded justified create latent dimension established research toth associates items although correlation interpreted analysed independent constructs elsevier ltd rights reserved
recent years scholarly attention paid growing range geographic characteristics antecedents inequalities women health well purpose study evaluate differences health related quality life rural urban polish postmenopausal women using data set reproductive health preventive screening postmenopausal women aged years inhabitants wielkopolska lublin provinces association place residence socioeconomic status lifestyle factors health related quality life instrument evaluated using ancova models multiple logistic regression analysis backward elimination steps consistent rural urban gradient found indices physical health functioning well vitality social functioning emotional role mental health scales women large cities likely enjoy highest villages lowest quality life rural urban disparities health related quality life mediated women socioeconomic status likelihood worse physical mental functioning well times greater low socioeconomic status rural women counterparts affluent urban areas educational attainment employment status powerful independent risk factors health related quality life rural urban women better understanding role socioeconomic status acts mediator association area residence health related quality life may useful developing public health policies health inequalities among women midlife published elsevier gmbh
violence exposure negatively impact early childhood development ecd yet limited research exists low middle income countries lmics study aimed determine effective integration ecd plus violence prevention ecd look like lmics seventeen key informants selected using purposive sampling representing agencies donors implementers research organisations using open coding semi structured interviews authors identify five priority areas promoting integrated ecd agenda parenting parent child relationships family systems iii development ecological context system strengthening integration building translating evidence john wiley sons ltd national children bureau
introduction alzheimer disease common form dementia incidence increasing alarming rate world pathophysiology characterized chronic progressive neurodegeneration involves early synaptotoxicity one obvious pathological feature accumulation amyloid brain since current treatment options provide symptomatic help thought underlie early synaptic pathology reduction modulation brain may promising therapeutic strategy preventing reversing related dysfunction areas covered paper outlines evaluates current landscape preclinical clinical studies focusing modulating pathophysiology data analysis review procured pubmed clinicaltrials gov alzforum expert opinion according current knowledge reducing production offers numerous treatment options however targeting initial steps pharmacological interference secretases challenging due emergence various side effects promising approach seems prevention early oligomerization combination approaches targeting tau would seem another promising strategy could beneficial effects course disease
canadian digestive health foundation initiated scientific program assess incidence prevalence mortality economic impact digestive disorders across canada current article presents updated findings study concerning gastroesophageal reflux disease condition develops reflux stomach contents causes troublesome symptoms complications montreal definition
introduce model hiv aids utilized assess impact combining pre exposure prophylaxis prep antiretroviral drugs arvs use interventions incorporating drug resistance mathematical numerical analyses carried investigate effects combined controls presence prep drug resistance results predict significant decrease number new hiv infections prep arvs concurrently implemented high levels results also reveal prep drug resistance potential slow reverse effects prep especially low efficacy levels elsevier inc rights reserved
proper recovery electromechanical products prevent pollution improve materials recycling rate make economic benefits well however major obstacle product lifecycle information essential recovery decision making difficult collected article shows radio frequency identification rfid utilised record trace lifecycle information hence optimising disassembly process improving recovery efficiency key factors integrated method demonstrated assembly disassembly model constructed purposefully due characteristics rfid flexible encoding storage approach using xml format proposed uniquely universal usage limited memory space rfid tags detailed iteration process automatic generation near optimum disassembly sequence illustrated addition set related application programmes developed whole integrated method verified case study integrated method highly extensible applied various types electromechanical products
paper methodology designing architecture processor array wide class image processing algorithms proposed concept spatially expanding sfg description enables handle problem merely one dimensional signal processing used constructing methodology problem interface critical real time processing also considered
recent years water pollution contamination incidents happened frequently causing serious disasters negative social impact reduce water contamination risk water quality monitoring sensors deployed water distribution system wds enable real time pollution detection desirable deploy sensors everywhere contamination event detected reported timely manner unfortunately luxury unrealistic vision high deployment cost significant lower deployment cost provided quality sensing coverage contamination detection time guaranteed effective depollution action paper consider water quality monitoring sensor network consisting two kinds sensors different prices expensive one cellular communication capability therefore able send sensing information control center directly cheaper one sensor sensor communication capability investigate cost efficient sensor deployment problem deploy two kinds sensors given wds minimize deployment cost without violating quality sensing requirement first formulate problem mixed integer quadratically constrained programming problem linearized equivalent mixed integer linear programming propose polynomial two stage heuristic algorithm evaluate efficiency via extensive simulation based studies
study aims investigate impact health belief model hbm based educational intervention knowledge beliefs self reported practices gestational postpartum weight women gestational diabetes mellitus gdm subjects methods cluster randomized controlled trial performed randomization level primary health care centers three egyptian cities eligible women gdm enrolled weeks pregnancy intervention group received health education intervention based hbm construct control subjects received usual care outcomes measured women knowledge beliefs self reported practices gestational weight gain gwg postpartum weight retention patients investigated baseline end pregnancy weeks postpartum results intervention percentages women high knowledge beliefs scores significantly increased less intervention group women intervention group reported practicing exclusive breast feeding screening tdm weeks postpartum compared control group respectively women excessive body mass index intervention group compared control group meeting recommended gwg postpartum weight respectively conclusion intervention significantly improved knowledge beliefs self reported practices gestational postpartum weight patients gdm research needed investigating effectiveness applying early multi phase longer intervention
polynomials finite fields play central role algorithms cryptography error correcting codes computer algebra complexity multiplying polynomials still major open problem let prime let denote bit complexity multiplying two polynomials degree less large compared establish bound nlogn log log log min epsilon log log stands iterated logarithm improves previously best known bound nlogn loglogn log essentially goes back
objective last large study second primary tumors spts women ovarian cancer published prior major changes differential diagnosis treatment present study reports incidence spts contemporary cohort patients diagnosis ovarian cancer methods ovarian cancer patients diagnosis ovarian malignancy identified characterized registries surveillance epidemiology end results database results women diagnosis ovarian malignancy developed microscopically confirmed spt significant difference risk developing spt sites women ovarian cancer general population elevated risk site specific spts small intestine vagina thyroid gland acute nonlymphocytic leukemia ovarian cancer patients compared general surveillance epidemiology end results population conversely risk lung non hodgkin lymphoma significantly decreased women ovarian cancer elevated risk spts observed women mucinous endometrioid germ cell tumors white women overall decreased risk developing second primary solid tumor whereas american indian asian pacific islander women overall increased risk spt site conclusions incidence spts women ovarian cancer significantly different compared general population however divergent rates spts relation histology latency age race observed
background low income ethnically diverse older adults may greater health risk owing lower activity levels potential cultural barriers physical activity programs explore specific barriers promoters enrollment week tai chi program interviewed lower socioeconomic older adults multiple ethnic backgrounds initiation program method semistructured qualitative focus group interviews conducted questions focused themes barriers promoters enrollment program might might culturally gender related results important issues emerged covered six categories categories included physical mental health time day socialization program pairing accessibility appropriate leadership teacher conclusion information may value tailoring future programming community could lead improved health outcomes better enrollment increased participation exercise
disciplines produce wide variety data materials engineering difficult provide infrastructure storing managing sharing exploring datasets particularly whilst data still use heterogeneous data centre hdc extension file server provides scientists tools exploring datasets managing relationships adding metadata many features evolved close consultation users paper evaluate hdc interface features managing datasets using data provided users materials engineering human genetics domains particular show simplicity capturing data file share flexibility extensibility system supporting hierarchical metadata dataset relationships plug ins elsevier ltd rights reserved
background osteoporosis associated cancer development conducted nationwide population based cohort study taiwan evaluate possible association osteoporosis subsequent cancer development methods total patients diagnosed osteoporosis identified national health insurance research database comprised osteoporosis cohort patient randomly frequency matched one individual general population without osteoporosis based age sex year osteoporosis diagnosis form non osteoporosis control cohort cox proportional hazard regression analysis used calculate adjusted hazard ratios confidence intervals determine effect osteoporosis cancer risk results patients osteoporosis showed significantly higher risk developing liver thyroid cancers lower risk colorectal cancer individuals without osteoporosis male patients osteoporosis significantly increased risk liver cancer whereas female patients osteoporosis significantly increased risk thyroid cancer significantly decreased risk overall colorectal cancers addition significant findings observed age years follow duration years however significantly lower risk colorectal cancer observed follow duration years study limits including lack data health related behaviors inclusion criteria osteoporosis potential selection bias discussed conclusion patients osteoporosis showed higher risk liver thyroid cancers lower risk colorectal cancer control individuals stratified analyses sex age follow duration showed various patterns different cancers
article design implementation innovative photovoltaic system prototype intelligent control lighting based arduino zigbee described lighting system connected power generation system composed isolated photovoltaic cells lighting control system subject vehicle detection permitting variation light intensity vehicles circulating highway variation light intensity control lighting system managed arduino microcontroller turn transmits information wirelessly luminaires distributed along highway thus expected lighting system present significant savings energy consumption making use innovative technologies
background agomelatine first melatonergic antidepressant postulated enhance dopaminergic activity central nervous system hydroxytryptamine receptor type htc antagonism yet impact melatonergic agonism pathway unclear previous studies employing simplified yet reliable proxy retinal measures central nervous system dopaminergic activity namely standard electroretinogram erg technique suggested reduction dopaminergic activity main erg parameter wave pure melatonin notably hormone devoid antidepressant activity therefore antidepressant effects melatonergic antidepressant drug agomelatine reflected differential wave trend erg versus effect exerted pure melatonin eventually found due contrasting effect central dopaminergic transmission two drugs objective methods aim present preliminary erg study carried healthy volunteers receiving agomelatine explore impact antidepressant drug wave amplitude latency cones daylight conditions using standard erg results postulated agomelatine induced enhancement retinal dopaminergic activity contrast previously documented melatonin conclusion given limits explorative study especially lack control group luminance response function measure retinal sensitivity studies clinical samples recommended allow tenable conclusions potential role erg discriminating antagonism melatonergic agonism relationship claimed antidepressant effect agomelatine
individuals high levels worry likely others attend possible threats although extent top attentional control processes bias unknown compared performance high low worriers probe discrimination task designed assess attention threat cues cognitive load load conditions expected difference groups confirmed high worriers likely attend threat cues low worriers importantly however significant effects involving condition cognitive load load significant association self perceived attentional control ability results suggest pathological worriers likely attend threat individuals low levels worry regardless task demands limited cognitive control resources finding consistent dominance habitual bottom influences top control processes biased attention threat
database models road inventories based classical schemes relational databases many related tables database designer establishes priori every detail consider relevant inventory management kind database presents several problems first adapting model applications new database features appear difficult addition different needs different sets road inventory users difficult fulfil schemes example maintenance management services road authorities emergency services different needs addition kind database adapted new scenarios countries regions may classify roads name certain elements differently problem complex language used scenarios used database design addition technicians need long time learn use database efficiently paper proposes flexible multi language multipurpose database model gives effective simple solution aforementioned problems authors published elsevier
behavior gas liquid two phase jets extensively studied many years due fundamental importance many multiphase systems understanding jet behaviors essential predicting many processes practical importance objective study investigate horizontal air water jet behavior annular nozzle ejector shallow water tank present effect overall jet behavior oxygen transfer characteristics air bubbles water experimental apparatus consisted electric motor pump annular nozzle ejector assembly high speed camera unit circulation water tank measuring controlling accessories images air water mixed jet issuing ejector analyzed qualitatively dissolved oxygen concentration measured using clean water unsteady state technique horizontal mixed jet behaves like buoyancy jet quasi horizontal bubble jet horizontal momentum jet owing momentum primary flow air bubble size concluded higher momentum primary water flow lower entrainment ratio smaller air bubble size buoyancy force air bubble penetration mixed flow found important parameters oxygen transfer rate owing contact area time two phases
purpose according kaiser family foundation florida children years age uninsured giving florida second largest number uninsured children united states florida covering kids families ckf dedicated developing innovative outreach methods enrolling retaining eligible children florida kidcare state children health insurance program ckf developed strong data system allows evaluate effectiveness success statewide enrollment retention efforts description data system created using checkbox survey systems community school outreach partners enter data month completed florida kidcare applications via secure interface system requires data entered uniform format forces vital data points completed data transmitted state obtain timely application determination information enrollments assessment data system helps ckf determine outreach strategies successful changes need made increase effectiveness system also provides feedback community outreach partners order enable follow families needed conclusion organizations helping uninsured children apply health insurance may benefit creating data collection systems monitor project efficacy modify outreach enrollment strategies greater effectiveness
cross sectional study involving multiple sclerosis patients healthy controls set determine association five blood biomarkers risk progression scores high levels semaphorina semaa females low levels prolactin estradiol males associated risk high disability correlated higher semaa levels females findings suggest clinical applicability semaa prolactin biomarkers progression however biomarkers sex specific associations therapeutic approaches utilizing take consideration elsevier rights reserved
studies social perception reveal many dimensions smiling individuals perceived positively comparison non smiling individuals experiment carried seven countries china germany iran norway poland usa republic south africa showed cultures smiling individuals may perceived less favorably non smiling individuals compared ratings intelligence made participants viewing photos smiling non smiling people results showed smiling individuals perceived intelligent germany china smiling individuals perceived less intelligent non smiling individuals iran suggest obtained effects explained cultural diversity within dimension uncertainty avoidance described globe global leadership organizational behavior effectiveness project house hanges javidan dorfman gupta
objective investigate effect client feedback group psychotherapy attendance treatment outcome patients eating disorders method conducted randomized clinical trial central randomization stratified diagnosis treatment type according computer generated allocation sequence concealed investigators one hundred adult participants diagnosed bulimia nervosa binge eating disorder eating disorder otherwise specified according dsm included eighty participants allocated experimental group participants control group groups received weekly group psychotherapy sessions experimental group participants gave received feedback therapy progress alliance measured session using outcome rating scale group session rating scale primary outcome rate attendance treatment sessions secondary outcome severity eating disorder symptoms measured eating disorder examination interview exploratory outcomes psychological distress measured symptom checklist outcome rating scale social functioning measured sheehan disability scale episodes self harm suicide measured modified version self harm inventory results feedback compared control affect rate attendance severity symptoms exploratory outcomes values conclusions feedback neither increased attendance improved outcomes outpatients group psychotherapy eating disorders results discussed different perspectives
background androgen receptor knockout male mice display hepatic steatosis suggesting signaling may regulate hepatic fat however effects testosterone replacement hepatic fat men unknown aim study determine effects testosterone administration hepatic fat older men mobility limitation low testosterone levels participating randomized trial testosterone older men trial methods two hundred nine men mobility limitation low total free testosterone randomized parent trial either placebo testosterone gel daily months hepatic fat determined magnetic resonance imaging men placebo testosterone group using volumetric method insulin sensitivity homeostatic model assessment insulin resistance derived fasting glucose insulin results baseline characteristics similar two groups including liver volumes testosterone group placebo group testosterone concentrations increased testosterone group change placebo group changes liver volume intervention differ significantly groups related treatment testosterone concentrations change homeostatic model assessment insulin resistance also differ significantly groups related either baseline change liver fat conclusion testosterone administration older men mobility limitation low testosterone levels associated reduction hepatic fat larger trials needed determine whether testosterone replacement improves liver fat men nonalcoholic hepatic steatosis
introduction nutritional deficiency anaemia lead development headache fatigue lethargy apathy exertional dyspnoea palpitations tinnitus thereby decrease quality everyday life great extent symptoms may pose hindrance students academic life negative impact career aim determine prevalence nutritional deficiency anaemia correlation academic performance among medical students materials methods cross sectional study conducted adichunchanagiri institute medical sciences two hundred eighty nine healthy undergraduate medical students genders included study predesigned prestructured questionnaire used tool obtain information regarding demographic profile dietary habits academic performance haemoglobin level estimated student test chi square test employed results majority participants within age group years overall prevalence anaemia high rates among female students gender difference statistically significant statistically significant difference among high low performers association anaemic status students scholastic performance chi conclusion mean haemoglobin level higher among low performer indicating nutritional anaemia may play major role educational performance intelligence higher education
world health organization estimates nearly million malaria tests performed annually microscopy rapid diagnostic tests rdts main diagnostic approaches single method inexpensive rapid highly accurate two recent studies group demonstrated prototype computer vision platform meets needs present results two clinical studies commercially available version technology sight diagnostics parasight platform provides malaria diagnosis species identification parasite quantification conducted multisite trial chennai india apollo hospital nairobi kenya aga khan university hospital compared device microscopy rdts pcr identification malaria device performed similarly well contexts sensitivity specificity indian site sensitivity specificity kenyan site compared pcr species identification device correctly identified samples plasmodium vivax samples plasmodium falciparum india samples vivax samples falciparum kenya compared pcr lastly comparisons device parasite counts trained microscopists produced average pearson correlation coefficients indian site kenyan site
thermodynamic kinetic characteristics cerium malonate complex formed first stage cerium oxidation malonic acid mal studied using spectrophotometer photometer meter ionic strength region sulfuric acid medium temperature composition found ceohmal form organic ligand mal thermodynamic parameters formation kinetic parameters intramolecular redox decomposition determined likely scheme initial stages redox proceeding mal system discussed quantitative model proposed
water saving stormwater retention benefits rainwater harvesting rwh tanks evaluated use behavioural models able simulate long term water balance rainwater tank however simulation results may affected computational time step normally chosen according aim analysis available data objective paper analyse influence time step evaluation performance rwh systems results investigation may help modellers deriving indications select appropriate time scale resolution evaluating water saving retention efficiencies rainwater tanks analysis carried reference household case study south italy high resolution rainfall data used run water balance simulation tank different daily sub daily time steps parallel event based data toilet flushes collected field monitoring household residential water demands used derive long term toilet water demand patterns different time scales aggregation simulations tank showed daily time step may reliably chosen accurate evaluation water saving volumetric stormwater retention efficiency rainwater tank exception small tanks high water demand values inaccuracies may occur unless higher time resolution adopted authors published elsevier ltd selection peer review responsibility ccwi committee
ige mediated reactions food allergens common cause anaphylaxis childhood although allergies cow milk egg soy proteins contrast peanut tree nut allergens resolve within first years life due natural tolerance development process well understood present cure treatment food allergy would result induction tolerance symptom eliciting food avoidance providing emergency plan education standard treatment oral immunotherapeutic approaches proven reasonable efficacy however associated high rates side effects low numbers patients achieving tolerance nevertheless mechanisms take place oral immunotherapy may help understand tolerance development basis therapeutic interventions events like loss basophil activation induction regulatory lymphocyte subsets blocking antibodies described functional importance clinical level however remains investigated detail consequently eminent need understand process tolerance development food allergens define biomarkers develop monitor new treatment strategies food allergy
sought identify kindergarten children simultaneously risk moderate severe symptomatology attention deficit hyperactivity disorder adhd conduct disorder adolescents risk factor estimates previously available conducted multinomial logistic regression analyses multiinformant ratings end middle school population based longitudinal sample children followed kindergarten eighth grade kindergarten children low ses households raised mothers depressive symptoms experiencing emotional problems substance abuse punished spanking significantly likely later display severe levels adhd symptomatology eighth grade kindergarten children frequently engaging adhd type behaviors likely later experience moderate covariate adjusted severe covariate adjusted adhd symptomatology low academic achievement uniquely increased risk moderate severe symptomatology adjusted range results guide early screening school based intervention efforts adhd reducing children risk adolescent adhd symptomatology may require remediating low behavioral academic functioning end kindergarten modifiable factors occur together increase kindergarten children odds experiencing severe adhd symptomatology eighth grade multiplicative factor
paper proposes explicit tuning rule multi loop pid controller brushless direct current motors predict system behaviors time frequency domains using properties convex combination method convex set proposed controllers formulates envelope satisfy performances time frequency domains final control parameters determined solving convex optimization problem subject constraints represented convex set time domain performances effectiveness proposed control method shown numerical simulation controller tuning algorithm dynamics brushless motor well taken account
imidazo pyridine one potential bicyclic heterocyclic rings recognized drug prejudice scaffold due broad range applications medicinal chemistry anticancer antimycobacterial antileishmanial anticonvulsant antimicrobial antiviral antidiabetic proton pump inhibitor insecticidal activities scaffold also represented various marketed preparations zolimidine zolpidem alpidem therefore several attempts made carry structural modifications scaffold discover develop novel therapeutic agents review provides valuable insight research findings wide range derivatives imidazo pyridine scaffold leading promising heterocyclic compounds could explored synthesis new derivatives well construction potential drug like chemical libraries biological screening search new therapeutic agents
purpose pain key symptom distinguishes bladder pain syndrome interstitial cystitis overactive bladder syndrome overlap occurs find discriminating marker bladder diseases examined sensory hyperinnervation neurotrophin receptor expression bladder biopsies well nerve growth factor levels urine materials methods bladder biopsies patients bladder pain syndrome interstitial cystitis including without hunner lesions overactive bladder syndrome healthy controls analyzed immunohistochemistry antibodies nerve cell marker pgp neuron specific protein gene product ntr neurotrophin receptor lymphocyte marker mast cell tryptase urinary nerve growth factor quantified enzyme linked immunosorbent assay results subepithelial sensory hyperinnervation pgp staining sensitivity specificity increased lymphocytic infiltration sensitivity specificity urothelial defects sensitivity specificity distinguish bladder pain syndrome interstitial cystitis without hunner lesions overactive bladder syndrome healthy controls increased sensory innervation associated submucosal mast cell localization staining ntr basal urothelial cells indicative bladder pain syndrome interstitial cystitis urinary nerve growth factor levels detection level differentiate bladder diseases healthy controls conclusions sensory hyperinnervation basal urothelial ntr staining together assessment inflammatory lymphocytes urothelial integrity allow differentiation bladder pain syndrome interstitial cystitis overactive bladder syndrome even absence hunner lesions furthermore histopathological criteria enable identification early disease stages oligosymptomatic asymptomatic cases may permit timely treatment prevent disease progress
article crafted around assessment analysis health risks associated domestic rooftop water harvesting india prime objective bringing forefront deterrent issues challenges rainwater harvesting general domestic rooftop water harvesting particular based study health risk assessment domestic rooftop water harvesting project conducted nagaur district rajasthan india providing critical reflection exemplifying prevalent scenario arid regions world methodology used deriving conclusions failure mode effects analysis set risks graded according severity based risk priority number scores evolved including various contaminants polluting harvested rainwater findings bear implications planning reconstructive changes incorporated thus providing necessary outlook effective alleviation deterrents make rainwater harvesting premium solution realization millennium development goals providing access safe drinking water populace chiefly developing countries problem scarce safe water grave
current methods measuring screw threads either time consuming expensive addition single measurement method available capable accurately measuring screw thread features significantly reducing measurement time paper introduces vision system automatic measurement inspection types screw threads many image processing computer vision algorithms developed analyze captured images screw threads perform measurement inspection processes common screw thread features features could measured introduced vision system system calibrated imperial metric units verified measuring standard iso metric thread plug gage comparing results measurements standard values results showed maximum difference standard measured values provide good accuracy measurement elsevier ltd rights reserved
objective prospective clinical imaging study conducted investigate pain processing functional pathways trigeminal heat stimulation ths patients migraine without aura experiencing ictal cutaneous allodynia mwoa methods using whole brain bold fmri functional response ths three different intensities degrees degrees degrees investigated interictally adult mwoa patients compared mwoa patients without ictal mwoa healthy controls hcs secondary analyses evaluated associations bold signal change clinical features migraine results moderate noxious ths degrees observed significantly greater activation anterior cingulate cortex mwoa patients compared hcs middle frontal gyrus mwoa patients compared mwoa patients hcs furthermore high noxious ths degrees significantly decreased activation secondary somatosensory cortices observed mwoa patients compared mwoa patients hcs mwoa patients compared hcs severity positively correlated secondary somatosensory cortices activation conclusions findings suggest may subtended dysfunctional analgesic compensatory mechanism abnormal internal representation pain migraine patients
bariatric surgery currently effective strategy treating severe obesity comorbidities type diabetes however mechanism bariatric surgery mediates benefits completely understood since obesity represent yet another inflammatory disease follicular helper tfh cells play important roles inflammatory disorders investigated whether tfh activity altered roux gastric bypass rygb one common bariatric surgery procedures found tfh cells rygb significantly changed number presented altered cytokine secretion profile including lower interferon ifn interleukin secretion tfh cells rygb also downregulated inducible stimulator programmed death interestingly tfh cell naive cell coculture tfh cells rygb secreted autologous tfh cells rygb frequencies expressing transforming growth factor tgf expressing regulatory cells tfh cell naive cell coculture directly correlated frequency expressing tfh cells depletion coculture however resulted fewer regulatory cells finally patients greater increase expressing tfh cells presented reductions body mass index glycaemia body fat percentage together data demonstrated tfh cells rygb presented lower inflammatory status secreted higher tfh cells promoted development regulatory cells higher expressing tfh cell level also predicted better patient response rygb
ethylhexyl phthalate dehp one widely used phthalates metabolites dehp detectable majority population findings adverse health outcomes particularly birth weight association prenatal exposure dehp remain equivocal besides insufficient evidence address influence metabolic function epidemiological studies thus objective investigate cord blood adipokine levels birth size association prenatal dehp exposure prospective birth cohort study mono methylhexyl phthalate mehp primary metabolite dehp determined exposure using maternal blood sample trimester leptin adiponectin levels cord blood measured markers metabolic function birth weight length obtained birth record association maternal mehp levels cord blood adiponectin leptin levels birth weight ponderal index examined mother child pairs mehp cord blood adipokine measurements median mehp level detection rate sex difference mehp levels leptin adiponectin levels higher girls boys mehp level positively associated adiponectin level among boys negatively associated leptin level among girls mehp level negatively associated girls could due decreased leptin level study suggested prenatal dehp exposure may associated cord blood adipokine birth size influence potentially sex specific could significant girls published elsevier
controversy whether associations psychosis violence due coexisting substance misuse factors increasing risk nonpsychotic persons recent studies clinical samples implicated independent effects paranoid delusions research findings suggest individual psychotic like experiences psychosis continuum general population associated violence remains unclear whether association due psychiatric comorbidity pooled data general population surveys conducted meta analysis individual subject data meta analyses performed identify heterogeneity main exposure variables psychotic like experiences categorical measure psychosis comorbidity established standardized self report instruments information collected violence severity victims paranoid ideation associated violence aor severity frequency even controlling effects psychotic like experiences associations explained comorbid conditions including substance dependence psychotic disorder associated violence injury perpetrator associations explained paranoid ideation individual associations hypomania thought insertion hallucinations violence nonsignificant adjustments significantly associated comorbid antisocial personality disorder strange experiences associated intimate partner violence paranoid ideation psychosis continuum general population associated violence associations explained comorbidity investigation determine whether paranoid ideation among persons community require preventive interventions similar presenting mental health services nevertheless risks considerably increased psychotic like experiences occurring antisocial personality disorder
medical robots frequently used minimally invasive surgery human body significant role reach position near back wall operating artificial organs play flexible multibody effectors paper proposes method dynamics simulation effector serial chain electric drives form motors pid controllers simulink effector consists four rigid bodies six degrees freedom rrrs configuration every joint effector driven mathematical model motor pid controllers applied steer movements joints velocity feedback loops parameters identified using descent gradient optimization algorithm created model dynamics serve instill algorithm running effector trajectory using method potential fields inside tunnel obtained using medical imaging model simulink allows connect model dynamics built using block diagram simmechanics code lines stored language kept created path planning algorithm
introduction study aimed determine prevalence asthma like symptoms among schoolchildren low birth weight lbw compare lung function children children normal birth weight methods comparative cross sectional study recruited children aged years eight primary schools kota bharu kelantan malaysia children divided two groups lbw parents enrolled children asked complete translated version international study asthma allergies childhood questionnaire lung function tests done using microloop spirometer performed children groups single investigator blinded children birth weight results prevalence ever wheezed among children lbw value significantly higher children normal birth weight forced vital capacity fvc forced expiratory volume one second forced expiratory flow fvc exhaled significantly lower among children lbw compared children normal birth weight conclusion lbw associated increased prevalence asthma like symptoms impaired lung function indices later life children born lbw may need additional follow future respiratory problems detected early
considering world population aging health support issues evidence many dangerous situations concerning users living environment may arise paper presents approach allow ambient assisted living aal systems identify predict situations may endanger users living environment elderly people generally difficulties perform daily activities using electronic device cooking dressing among others paper offers alternative acquire comprehension former person behavioral providing knowledge cognitive impairments occur significant improvement traditional expert systems applied aal handling knowledge base adapted failing users behavior consider user profile dynamics new different situations initially planned development systems may occur approach developed considering principles reactive proactive behavior extensibility capacity system systems developed following described principles react current situations anticipate proactively dangerous situation eliminating controlling impact approach evaluated verified case study unwanted dangerous situations created subsequently detected case study based simulated smart house fulfilled sensors appliances application build based developed approach capable choosing appropriate actions solve unwanted situations main contributions present work identification prediction situations smart houses approach developed principles reactive proactive behavior validated case study supported probabilistic ontology elsevier ltd rights reserved
article considers design features main modifications analog interface sensor systems implemented base differential difference amps dda unlike classical structures instrumentation amplifiers junction coupling stages suggested circuit solutions give small suppression offset voltage provide common mode rejection conditions radiation low temperature effects feeding inherent compensation circuits parasitic impedances circuit according algorithm extends bandwidth factor article suggests new modifications two stage ddas higher voltage gain
many approaches proposed aiming reduce cost join operations join operations represent key factor inquiry process retrieve related information different data tables large relational databases yet still need intelligent query optimizing approaches reduce response time query execution paper proposes approach reaching optimal query access plans complex relational database queries including set join operations proposed approach based ant colony optimization technique benefit ability parallel search several constructive computational threads aims reach optimal query access plan comparative study shows added value proposed approach
essay offers paths scholars influenced critical social sciences theoretical humanities contribute construction concepts digital practices data allow data better align approaches scholarly inquiry particular explores geographic information might refashioned rereading simplified theoretical positions drawn interpretative inquiry process relational thought new materialisms geographic information largely called forth self sufficient entities intensive properties indexed location absolute space known objectively geographic gaze contrast article suggests ways geographic information may reimagined constitute spaces relational matter vibrant knowledge situated claims seen interpretative boundaries previously considered roles reader researcher data structures observer observed may also need reordered implications ways interface data although paths difficult travel hold promise extending reach interpretative non positivist empirical practice well favorably altering terms interpretative scholars participate debates around practices data today
adjoint based method calculating impacts observations met office global four dimensional variational assimilation var system documented approach novel seek outset linearized approximation partition finite impact batch observations method results similar systems large beneficial impacts measured satellite radiances radiosonde soundings system interesting results also identify areas potential improvement assimilation northern hemisphere stratospheric satellite radio occultation gpsro observations polar atmospheric motion vectors tropical cyclone bogus observations synthesized automatically tropical cyclone warning centre advisory messages use toy model explain observations improve forecast growing modes observational errors errors verifying forecast contribute approximately equally suggest necessarily imperfect knowledge background error statistics also contributes
paper deals control concentrating parabolic solar collectors forcing outlet oil temperature track set reference fuzzy universal approximate model introduced order accurately reproduce behavior system dynamics proposed model low order state space representation derived partial differential equation describing oil temperature evolution using fuzzy transform theory resulting set ordinary differential equations simplifies system analysis control law design suitable real time control implementation simulation results show good performance proposed model
paper presents amplitude modulation transmitter mhz application low power consumption transmitter consists gilbert cell mixer cross coupled symmetric load voltage controlled oscillator two stage operational amplifier high pass filter implemented tsmc cmos process input mhz output ghz applied ports mixer conversion gain results output ghz reference voltage tuning range oscillator ghz amplifier gain phase margin degrees unity gain bandwidth ghz slew rate overall power consumption chip size chip connected pad rectangular pad frame size
paper necessities green building energy saving technology developed analyzed detail understand impact green building energy saving technology developed future development country people construction green building energy saving technology system analyzed problems process building energy saving technology system green building analyzed main construction direction green building energy saving technology system obtained
recent decades discrete event simulation des widely used analyzing construction projects recently fuzzy discrete event simulation fdes integration fuzzy set theory des proposed simulating construction projects fdes provides framework consider subjective uncertainty uncertainty due vagueness subjectivity linguistic expression knowledge construction simulation models current fdes frameworks calculate simulation time project completion time simulation output however queue performance measures average queue length waiting time though important simulation model outputs decision making finding bottlenecks optimizing construction resources analyzed current fdes methodologies using fuzzy logic consider subjective uncertainty service time inter arrival time systems queues may improve simulation models realistically representing results paper provides novel methodology consider subjective uncertainty analyzing fuzzy queues construction fdes models incorporating fuzzy queuing theory fdes methodology proposed paper enhances applicability fdes construction projects proposed methodology validated mathematically solved queueing examples practical aspects illustrated using example asphalt paving operation elsevier rights reserved
study effect urbanization environmental pollution qualitative structural quantitative changes corylus avellana hazel pollen investigated using scanning electron microscopy fourier transform infrared ftir spectroscopy curve fitting analysis amide profile obtained spectroscopic results show significant variations fraction proteins hazel pollen probably depend various degrees anthropopression results suggest alterations chemical composition pollen induced urbanization air pollutants may intensify allergenic potential may cause increase incidence allergies people mutations nucleic acids accompanied number molecular changes leading formation allergenic proteins seems type habitat pollen grew affects individual differentiation indeed found site exhibiting low pollution hazel pollen contain lower amount proteins ones site high anthropopression hence ftir spectroscopy curve fitting analysis amide profile successfully applied tools identifying quantitative qualitative changes proteins hazel pollen anthropogenic factors air pollution urbanization lead changes structure chemical composition hazel pollen fourier transform infrared spectroscopy ftir gaussian analysis showed structural changes hazel pollen collected sites different absorbance values individual chemical functional groups changes secondary structure proteins pollen graphics
renewable nuclear energy provide significant contributions decarbonizing electric sector however grid employing large amounts wind solar energy requires balance system highly flexible respond increased variability net load makes deployment conventional nuclear power challenging due technical challenges plant cycling economic limits reduced capacity factor united states nuclear power plants generally provide constant base load power economic operated constant power levels operating nuclear power plants load following modes decreases plants annual energy output increases levelized cost energy decreasing economic competitiveness one possible solution couple thermal energy storage nuclear power plants would enable reactor remain nearly constant output cycling electrical generator response variability net load paper conceptually explores combinations wind solar nuclear provide large fraction system electricity assuming use thermal energy storage would allow nuclear power provide load following cycling duty operating constant reactor power output published elsevier ltd
among new cancer cases average caused helicobacter pylori oncoviruses including epstein barr virus human papillomavirus hepatitis virus hepatitis viruses kaposi sarcoma associated herpesvirus human lymphotropic virus pathogens encode variety non coding rnas important cofactors oncogenesis review focus recent developments study long small non protein coding rnas including micrornas oncogenic pathogens discuss mechanisms action multiple steps oncogenesis
peer interventions delivered prisoners prisoners offer means improve health reduce risk factors population variety peer programs poses challenges synthesizing evidence article presents typology developed part systematic review peer interventions prison settings peer interventions grouped four modes peer education peer support peer mentoring bridging roles addition number specific interventions identified review process article discusses different modes peer delivery reference wider health promotion literature value social influence support conclusion typology offers framework developing evidence base across diverse field practice correctional health care
background aims evaluate clinical course hip arthritis risk factors hip joint replacement patients ankylosing spondylitis methods retrospective analysis evaluated patients single tertiary hospital baseline recent visit outpatient clinic patients hip arthritis radiographic hip arthritis evaluated using bath ankylosing spondylitis radiology hip index basri also average hip joint space width interbone distance three distinct sites acetabulum femoral head recorded results among patients patients hip arthritis erythrocyte sedimentation rate associated hip involvement odds ratio confidence interval long disease duration advanced axial disease associated severe hip arthritis basri baseline basri interbone distance significantly change patients hip involvement follow period months five patients hip joint replacement surgery follow period body mass index bmi basri baseline associated joint replacement surgery hazard ratio respectively conclusions patients hip arthritis showed significant radiographic progression follow period high bmi advanced hip arthritis baseline associated hip joint replacement surgery patients
changes expression cornified envelope proteins thought affect development course atopic dermatitis aim study examine expression level proteins order identify new molecular markers phenotype expression levels proteins evaluated skin patients biopsies healthy subjects biopsies levels flg flg sprr mrnas proteins reduced skin levels lelp sprra transcripts proteins significantly increased skin sprrv mrna level non lesional skin correlated severity sprr protein level non lesional skin correlated inversely pruritus flg protein level skin correlated inversely severity results point sprr important factor itch
imaging techniques detection molecular cellular processes precede accompany lung diseases needed matrix metalloproteinases mmps play key roles development pulmonary pathology objective study investigate feasibility vivo mmp targeted molecular imaging detection lung inflammation remodeling methods lung specific trans genic club cell kda protein mice wild type littermates used study lung structure gene expression mmp activity assessed histology real time reverse transcription polymerase chain reaction western blotting zymography mmp activation imaged vivo small animal spect followed vivo planar imaging signal specificity addressed using control tracer correlation vivo mmp signal gene expression addressed results mice developed considerable pulmonary tissue remodeling inflammation mmp mmp significantly higher lungs vivo small animal spect vivo planar images mmp signal significantly higher lungs mice wild type animals furthermore nonbinding analog tracer showed significantly lower accumulation lungs relative specific tracer significant correlation small animal spect derived mmp signal expression lungs conclusion small animal spect based mmp targeted imaging lungs feasible reflects pulmonary inflammation validated humans molecular imaging inflammation remodeling potentially help early diagnosis monitoring effects therapeutic interventions pulmonary diseases
gene coding progranulin grn major gene linked frontotemporal lobar degeneration pathogenic grn mutations null mutations leading haploinsufficiency grn missense mutations obvious pathogenicity revealed act different pathogenetic mechanisms cytoplasmic missorting protein degradation abnormal cleavage elastase aim study disclose pathogenetic mechanisms grn missense mutation previously reported alter physiological progranulin features associated reduced plasma progranulin level investigating family pedigree performed genetic biochemical analysis members performed rna expression studies found mutation segregates disease discovered pathogenic feature alteration grn mrna splicing actually leading haploinsufficiency thus facing missense grn mutation pathogenetic effects investigated especially associated low plasma progranulin levels determine nature either benign polymorphism pathogenic mutation elsevier inc rights reserved
recently embedded systems become popular rising demand portable low power devices common task devices object tracking essential part various applications object tracking video sequences remains challenging problem visual properties objects surrounding environments among common approaches particle filter proven effective dealing difficulties object tracking research develop particle filter based object tracking method using color distributions video frames features deploy embedded system particle filter high complexity algorithm utilize computing power embedded systems implementing parallel version algorithm experimental results show parallelization enhance performance particle filter deployed embedded systems
electronic networks practice become prevalent means acquiring new knowledge knowledge seekers commonly turn online repositories constructed networks find solutions domain specific problems questions yet little understood process knowledge evaluated adopted knowledge seekers study examines individuals filter knowledge encountered online forums common platform knowledge exchange electronic network practice drawing dual process theory develop research hypotheses regarding central peripheral evaluation knowledge hypotheses examined field experiment participants evaluate online solutions computer programming problems results show peripheral cues source expertise validation greater influence knowledge filtering decisions content quality solution moreover elaboration increases effect content quality seem attenuate effect peripheral cues implications research practice discussed
halftoning inverse halftoning algorithms important image processing tools widely used development digital printers scanners steganography image authentication systems applications require obtain high quality gray scale images halftone versions development efficient inverse halftoning algorithms able provide gray scale images peak signal noise ratio psnr higher research topic last several years although psnr may enough several applications exist several require higher image quality reduce problem paper proposes inverse halftoning algorithms based atomic function multi layer perceptron neural network provides gray scale images psnrs higher independently method used generate halftone image
objective assess body composition patients inflammatory rheumatic disease effect tnf inhibitors methods systematic review meta analysis studies consulted pubmed cochrane library embase assessing body composition patients rheumatoid arthritis spondyloarthritis compared patients healthy controls body components tnf inhibitors results among articles reviewed met inclusion criteria patients rheumatoid arthritis significant increase fat mass adiposity android mass significant decrease lean mass observed patients spondyloarthritis significant modest increase fat mass significant decrease lean mass observed nine studies assessed impact tnf inhibitors body composition increase fat mass short long term studies data lean mass controversial two studies found increase visceral android mass tnf inhibitors conclusion patients inflammatory rheumatic disease significant decrease lean mass increase fat mass use tnf inhibitors associated increase fat mass including android fat could potentially cardiovascular consequences
address problem testing digital shapers used nuclear spectroscopy particularly propose solution based oscillation based test obt testing finite impulse response fir filters shaper obt strategy developed exploits natural partition system high pass low pass sections implementing two different non linear oscillators oscillation parameters obtained advance using two different approaches one based filter signal flow graph based oil describing function technique fault simulation results show high fault coverage acceptable test time additionally suggest use test strategy bist environment need resources pattern generation presents low system intrusion low hardware overhead
highly reliable deterministic communication network required guarantee protection switch control data acquisition international thermonuclear experimental reactor iter pulsed power electrical network ppen substation study aims quantitatively assessing availability indices evaluating end end ete time delay performance ppen communication network overall architecture ppen communication network first introduced theoretical analysis ppen communication network unrepairable repairable condition examined sensitivity analysis carried find best way improve availability subsequently opnet modeler used simulate message communication ppen communication network time delay test taken prove correctness simulation model results indicate ppen communication network availability indices meet iter requirement ete time delay conforms iec
purpose present study aimed investigate association hypertension physical functional capacities community dwelling older females materials methods older female volunteers dichotomized two groups hypertensive normotensive volunteers medical records reviewed underwent evaluations anthropometric data weight height body mass index physical functional capacities results results showed hypertensive older females presented higher values age weight body mass index resting diastolic blood pressure normotensive older females normotensive older females showed higher performance one leg stand test six minute walk test compared hypertensive older females age body mass index maximal walking speed performance time six minute walk test diagnosis diabetes mellitus type factors associated hypertension using chi square test however multivariate regression analysis indicated performance six minute walk test factor associated hypertension conclusions patients higher scores six minute walk test associated aerobic capacity show less odds clinical diagnosis hypertension however hypertension associated poor physical functional capacity
study extended research correlates adaptive functioning high functioning children autism spectrum disorder hfasd using behavior assessment system children second edition basc specifically study investigated relationships adaptive behavior age asd symptomology well characterized sample children hfasd ages years results revealed age significantly correlated adaptive ability however total autism symptoms measured autism diagnostic interview revised adi well asd social symptoms negatively correlated adaptive ability mean comparisons revealed participants falling clinically significant range basc adaptive skills composite asc displayed significantly greater levels overall social asd symptoms
paper presents new senior health monitoring system using kinect device monitor elderly people detect likely fall measuring gait analyzing change posture change sitting standing vice versa support vector machine used analyze gait posture data obtained kinect device several experiments performed evaluate proposed system experimental results well research experience using kinect device presented
propofol safe well tolerated anesthetic labeled contraindicated patients egg soy allergy contraindication become increasingly problematic given rising incidence food allergy eosinophilic esophagitis eoe address issue studied practice patterns propofol use esophagogastroduodenoscopies children eoe food allergies institution retrospective observational study esophagogastroduodenoscopies january june performed data analyzed using student tests chi square tests fisher exact tests multivariable logistic regression found propofol used significantly less patients egg soy allergy patients eoe even adjusting presence food allergy difference complication rates relative propofol use propofol used safely pediatric patients eoe food allergy limited single center review
hereditary angioedema normal esterase inhibitor mutations gene hae fxii associated skin swellings abdominal pain attacks risk asphyxiation due upper airway obstruction occurs nearly exclusively women report experience treating hae fxii discontinuation potential trigger factors drug therapies study included patients hae fxii potential triggers included estrogen containing oral contraceptives eoc hormonal replacement therapy angiotensin converting enzyme inhibitors drug treatment comprised plasma derived inhibitor pdc inh acute swelling attacks progestins tranexamic acid danazol prevention attacks discontinuation eoc effective women led reduction number attacks ending hormonal replacement therapy three eight women became symptom free three women exacerbation hae fxii intake quinapril enalapril hae fxii attacks discontinuation drugs eleven women treated pdc inh facial attacks duration treated facial attacks mean significantly shorter previous untreated facial attacks women mean mean reduction attack frequency progestins discontinuing eoc women tranexamic acid four women danazol three women patients hae fxii various treatment options available completely least partially reduce number duration attacks
objective study evaluated skeletal effects butanolic fraction passiflora foetida estrogen deficient mice bone loss model study design skeletal effect studied ovariectomized ovx female balb mice day dose orally given weeks micro architecture long bones biomechanical strength formations mineralized nodule bone marrow osteoprogenitor cells osteoid formation bone turnover markers studied one way anova used test significance effects passiflora foetida results ovx mice treated represented better micro architectural parameters various anatomical positions better bone biomechanical strength osteoprogenitor cells bone marrow compared ovx group exhibit uterine estrogenicity conclusion oral administration doses day derived passiflora foetida found afford anti osteoporotic effect estrogen deficiency likely stimulation osteoblast function inhibition osteoclast function elsevier masson sas rights reserved
background little known prevalence adhd symptoms bulimia nervosa binge eating disorder even less eating disorders knowledge gap clinical importance since stimulant treatment proven effective binge eating disorder discussed treatment possibility bulimia nervosa objective study explore prevalence types self reported adhd symptoms unselected group eating disorder patients assessed specialized eating disorder clinic methods total adults eating disorder assessed battery standardized instruments measuring inter alia adhd screening demographic variables eating disorder symptoms psychiatric comorbidity chi square tests used categorical variables kruskal wallis tests continuous variables results almost one third patients scored screening cut indicating possible adhd highest prevalence rates found bulimia nervosa anorexia nervosa bingeing purging subtype eating disorder otherwise specified type binge eating disorder patients reported slightly average anorexia nervosa restricting subtype patients even lower presence binge eating purging loss control eating non anorectic bmi related results indicating possible adhd psychiatric comorbidity correlated adhd symptoms without explaining differences eating disorder diagnoses conclusions high frequency adhd symptoms patients binge eating purging eating disorders motivates studies particularly concerning effects adhd medication finding frequency adhd symptoms anorexia nervosa binge eating purging high bulimia nervosa highlights need also group
cytokines tumour necrosis factor tnf interleukin interferon ifn recently implicated initiation maintenance inflammation psoriasis psoriatic arthritis psa present study aimed characterize role cells peripheral blood synovial fluid psa patients investigate response vitro stimulation antigen cytokines cells isolated peripheral blood mononuclear cells synovial fluid analysed flow cytometry evaluate phenotype cytokine production gene expression also evaluated reverse transcription polymerase chain reaction pcr peripheral blood mononuclear cells pbmc sorted cells cell lines also stimulated vitro isopentenyl pyrophosphate ipp recombinant recombinant results show expansion cells predominant effector memory phenotype peripheral blood synovium untreated psa patients reverses significantly treatment anti tnf anti monoclonal antibodies mabs moreover psa patients cells activation driven prevalently interaction together findings indicate cells new players pathogenesis psa
paper proposes real options model estimating optimal subsidy renewable energy power generation project using stochastic process describe market price electricity price investment cost two indicators project value threshold value used derive optimal subsidy least squares monte carlo simulation method used solve model proposed model used empirically evaluate optimal level subsidy solar photovoltaic power generation china results show carbon emission trading scheme helps reduce subsidy unit generating capacity market price electricity price volatility investment cost negatively related subsidy whereas investment cost volatility electricity price price positively related subsidy suggested chinese governments take measures promoting technological progress establishing nationwide carbon emission trading market promoting competition renewable energy industry well maintaining stability price electricity price reduce required subsidy
purpose study examine utility systematic observation red flags observational level two screening measure detect risk autism spectrum disorder toddlers used video recorded administration communication symbolic behavior scales psychometric properties systematic observation red flags examined sample toddlers months old autism spectrum disorder developmental delays typically developing individual items examined performance create algorithm improved sensitivity specificity yielding total composite score domain scores social communication restricted repetitive behaviors codes indicating clear symptom presence collapsed yield count number red flags overall scale symptom domain results indicated significant group differences large effects composite domain scores red flags score good discrimination area curve autism spectrum disorder nonspectrum groups composite social communication domain social communication red flags score systematic observation red flags provides observational screening measure month olds good discrimination sensitivity specificity cutoff composite recommended optimally detect autism spectrum disorder risk
goal paper identify individuals analyzing gait instead using binary silhouettes input data done many previous works propose evaluate use motion descriptors based densely sampled short term trajectories take advantage state art people detectors define custom spatial configurations descriptors around target person obtaining rich representation gait motion local motion features described divergence curl shear descriptor jain jegou bouthemy better exploiting motion better action recognition proc ieee conf computer vision pattern recognition cvpr extracted difierent spatial areas person combined single high level gait descriptor using fisher vector encoding perronnin sanchez mensink improving fisher kernel large scale image classification proc european conf computer vision eccv proposed approach coined pyramidal fisher motion experimentally validated casia dataset tan tan framework evaluating effect view angle clothing carrying condition gait recognition proc int conf pattern recognition vol parts tum gaid dataset hofmann geiger bachmann schuller rigoll tum gait audio image depth gaid database multimodal recognition subjects traits vis commun image represent cmu mobo dataset gross shi cmu motion body mobo database technical report cmu robotics institute recent ava multiview gait dataset lopez fernandez madrid cuevas carmona poyato marin jimenez munoz salinas ava multi view dataset gait recognition activity monitoring multiple distributed sensing lecture notes computer science springer results show new approach achieves state art results problem gait recognition allowing recognize walking people diverse viewpoints single multiple camera setups wearing different clothes carrying bags walking diverse speeds limited straight walking paths
background parenteral nutrient mixtures may pose great risks physical microbiological chemical contamination preparation storage distribution administration potential hazards must controlled high levels excellence prevent serious complications patients result management control traceability medications utmost relevance patient care along ensuring treatment continuity adherence objective aim study develop mobile based platform support control procedures traceability services domain parenteral nutrient mixtures efficient nonintrusive manner methods comprehensive approach combining techniques software engineering knowledge engineering used characterization framework local try outs evaluation performed number application areas carrying test retest monitoring detect possible errors conflicts different contexts control processes throughout entire cycle data absolute relative frequencies percentages calculated results mobile application android operating system developed application allows reading different types tags interacts local server according proposed model also internal caching mechanism availability system preserved even event problems network connection set test traces generated assessment system various environments tested among traces involved conflictive situations properly taken care paper suggesting solutions overcome conclusions mobile oriented system generated tested order allow enhanced control quality management mixtures easy integrate daily praxis health care processes
gender offender proved important factor judicial sentencing study analyze judgments college students regarding perpetrators familial homicides evaluate presence gender norms biases larger society sample included college students female enrolled several social sciences engineering courses participants asked read vignettes based real crimes taken portuguese newspapers half related infanticide half related intimate partner homicide sex offender orthogonally manipulated type crime results show gender important impact sentences males harshly penalized reasons perversity women less penalized reason mental disorders addition filicide heavily penalized intimate partner homicide results also revealed tendency toward retributive conception punishment discuss gender norms justice seem embedded society well need intervention punitive tendency population
paper adaptive rotor flux observer developed observer performs real time correction mutual inductance rotor resistance motor using data link voltage sensor inverter state phase current position sensors observer compares behavior two independent observers sensorless sensored observers order correct parameters sensored observer adaptation algorithm corrects mutual inductance vary due change magnetization current rotor resistance change due variation rotor temperature computer simulation results presented validate proposed method
torch ignition engine system combustion starts pre combustion chamber pressure increase pushes combustion jet flames calibrated nozzles precisely targeted main combustion chamber paper presents layout prototype engine developed fuel injection system continues detailed description performance torch ignition engine running gasoline ethanol blend different mixture stratification levels well engine speeds loads also detailed analyses specific fuel consumption thermal combustion efficiency specific emissions main combustion parameters carried numerical model based thermodynamic kinetic analyses established order explore performance limit stratified torch ignition engine paper concludes presenting main numerical results obtained work show significant increase torch ignition engine performance compared commercial baseline engine elsevier ltd rights reserved
background neuroscience research non human primates usually requires animals sit chair typically monkeys fitted collars trained enter chairs using either pole leash jump cage animals may initially show resistance risk injury developed automated chair training method minimizes restraints ease animals chairs new method developed method automatically train animals enter primate chair stick heads neckplate placement fitted chairs arduino microcontrollers coupled water reward system touch proximity sensors results comparison existing methods found animals responded well chair partially entering chair within hours sitting inside chair within days allowing manually introduce door neck plate within sessions although session could last many hours automation meant actual training person hours could little half hour per day biggest advantage animals showed little resistance entering chair compared monkeys trained leash pulling conclusions automated chair training method take longer standard collar leash approach multiple macaques trained parallel fewer person hours also promising method animal use refinement case effective training approach animal suffering behavioral pathology elsevier rights reserved
endothelial cells ecs line interior blood lymphatic vessels experience spatially varying wall shear stress wss intrinsic part physiological function ecs mammalian cells generally sense spatially varying wss remains poorly understood due part lack convenient tools exposing cells spatially varying flow patterns built multiplexed device termed well impinging flow chamber imparts controlled wss gradients six well tissue culture plate using device investigated migratory response lymphatic microvascular ecs umbilical vein ecs primary fibroblasts epithelial cells wss gradients hours days timescales observed lymphatic microvascular ecs migrate upstream direction flow response unique among cells types investigated time lapse live cell imaging revealed microtubule organizing center relocated upstream side nucleus response applied wss gradient demonstrate utility device screened involvement canonical signaling pathways mediating upstream migratory response data highlight importance wss magnitude wss spatial gradients dictating cellular response fluid flow
molten salts mixtures widely used heat transfer fluid research area solar energy applications measured viscosities molten salts often show large discrepancies due difficulties measurement elevated temperatures especially molten salt mixtures paper theoretical model presented predicting viscosity binary molten salts data viscosity density fraction component salt needed comparisons experimental data show model gives prediction viscosity errors less though part error may probably come experiment comparison eyring equation always gives larger errors reaching worst case present work indicates model shows improved ability prediction viscosity molten salt mixtures elsevier ltd rights reserved
objective objective study determine lower urinary tract symptoms luts associated risk factors women aged years methods study carried total women data collected january july research instruments interview form questions questioned personal characteristics developed researchers bristol female lower urinary tract symptoms bfluts questionnaire evaluating lower urinary tract symptoms used linear regression analysis used detect associated risk factors results rates urgency urinary incontinence nocturia frequency symptoms respectively bfluts total scores increased age present study detected statistically significant differences bfluts scores women demonstrated statistically significant differences according several risk factors including menopause status presence chronic illness medicine use recurrent urinary tract infections body mass index bmi delivery number chronic constipation multiple linear regression analysis determined frequent urinary tract infections presence chronic illness chronic constipation bmi number deliveries significantly related luts development conclusion common luts urgency women aged years older recurrent urinary tract infection determined significant risk factor luts followed chronic illness chronic constipation higher bmi parity
article presents vibration control performances semi active railway vehicle suspension system using magneto rheological damper tested roller rig order evaluate control performances mathematical railway vehicle model degrees freedom first derived represent lateral yaw roll motions car body bogie frame wheel set respectively based formulated model design parameters magneto rheological damper determined undertake compatible comparison dynamic performances conventional existing passive railway vehicle suspension system designed magneto rheological damper manufactured field dependent damping force characteristics experimentally evaluated subsequently order enhance ride quality railway vehicle suspension equipped magneto rheological damper skyhook controller associated extended kalman filter designed state space representation railway suspension system incorporated car body two bogies experimentally set roller rig order evaluate ride quality demonstrated experimental realization controller ride quality suspension system magneto rheological damper significantly enhanced compared existing passive suspension system
copper metal choice electrical circuits electronics lower cost silver offers excellent electrical properties like low electrical resistivity electromigration resistance physical vapor deposition wet chemical etching electroforming standard processes used deposit pattern copper silicon printed circuit board technology recently copper inks pastes become available printing copper films potential outcome lowering production cost beyond established processes furthermore printing processes compatible role role fabrication hence attractive flexible electronics study modal copper paste containing nano micro particles transferred relief printing process using silicon stamps possible demonstrate electrical conductive tracks linewidth spacing neighboring tracks related width low possible achieve sheet resistance less ohm formic acid assisted sintering degrees low sintering temperature enables direct placement electronic components without additional soldering thus saves time production costs
paper presents findings latest stage prospective medical sociological monitoring cohorts families goal trace development child health monitoring carried vologda oblast institute sodo economic development territories russian academy sciences since receives support department health care vologda oblast monitoring shows real time dynamics children health development reflects dependence changes factors influence specific examples show factors parents lifestyle environment children brought financial welfare medical health related activities diet nutrition housing environmental conditions influence children health past years russian federation undergone fundamental changes affected important aspects social life russia political economic structure changed country experienced two socio economic crises implemented intensive reforms key sectors education health care housing utilities sector agriculture changes economy significant impact public health children health first place basis studies authors show positive trends reforms economy general social sphere particular trends reflected living conditions families children level health satisfaction state health newborns obstetric care statistics paper presents major factors contributing presence functional abnormalities health newborns quality living conditions families income level health status mother maternal smoking
objective clinical hormonal chromosomal analysis undervirilized male disorder sex development make presumptive etiological diagnosis according new disorder sex development dsd classification system study design case series place duration study endocrine unit national institute child health karachi pakistan january december methodology patients suspected dsd undervirilized male visiting endocrine clinic enrolled study criteria suggested dsd include overt genital ambiguity apparent female male genitalia inguinal labial mass apparent male genitalia unilateral bilateral non palpable testes micropenis isolated hypospadias undescended testis older children delayed puberty also evaluated respect dsd part evaluation dsd abdominopelvic ultrasound karyotype hormone measurement testosterone fsh fish analysis sry probing genitogram laparoscopy gonadal biopsy hcg stimulation test performed frequencies percentages applied categorical data whereas mean median standard deviation calculated continuous data results total patients met criteria dsd age ranged month years presented infancy years older years twenty five raised female male main complaints ambiguous genitalia unilateral cryptorchidism bilateral cryptorchidism micropenis delayed puberty hypospadias female like genitalia gonads inguinal mass karyotype xxy patient hcg stimulation test showed low testosterone response high testosterone response partial testosterone response normal testosterone response genitogram carried patients presumptive etiological diagnosis androgen sensitivity syndrome alpha reductase deficiency testicular biosynthetic defect leydig cell hypoplasia partial gonadal dysgenesis ovotesticular dsd testicular dsd mixed gonadal dysgenesis testicular vanishing syndrome klinefelter syndrome hypogonadotropic hypogonadism isolated hypospadias isolated micropenis made conclusion clinical chromosomal hormonal assessment may help making presumptive etiological diagnosis molecular genetics analysis needed differentiating abnormalities make final diagnosis
neglected tropical disease melioidosis known variability clinical presentations described clinical features alert physicians possibility melioidosis review cases common presentations melioidosis emergency department hospital universiti sains malaysia male gender working age group year old worked contact soil presented fever rainy season underlying diabetes mellitus leukocytosis high blood glucose presentation cases antimicrobials initiated include antimelioid drugs thirty one patients died due melioidosis within admission despite high mortality rate clinical awareness possibility melioidosis among emergency physicians still low need strengthened
rationale tobacco higher rate dependence drugs abuse however psychopharmacological effects nicotine incongruent tenacity tobacco addiction since nicotine produce robust euphoria humans self administration rodents potential explanation nicotine amplifies salience stimuli incentive value could influence initiation persistence smoking however neural mechanisms process unknown objectives one way nicotine may amplify salience stimuli enhancing reward prediction errors hypothesized nicotine would enhance neural response unexpected relative expected rewards compared placebo methods twenty three nonsmokers underwent two fmri scans following nicotine placebo administration performing outcome expectation task task pair cues associated either subsequent reward image bill nonreward image blurry rectangle trials cue followed unexpected outcome results although nicotine affect magnitude prediction errors relative placebo nicotine increase bold activation anterior insula inferior frontal gyrus decrease activation caudate across outcome types including rewards nonrewards conclusions insula caudate could play role initial effects nicotine nonsmokers changes baseline may mechanism underlies nicotine amplifies salience nondrug stimuli
paper proposes study impacts distributed generation energy losses voltage drop line gjilani distribution system input data including lengths impedance distribution lines maximum load max used create network model using digital simulation electrical network calculation program digsilent power factory model used analyze power energy losses voltage drop lines distribution system addition capacity location connected distribution system considered results show enough capacity installed power energy losses voltage drop last point line reduced
nearly half million infants united states born preterm low birth weight year providing women prior adverse birth outcome access family planning help reduce incidence subsequent high risk pregnancies adverse outcomes one effective option prevent unintended pregnancy women prior adverse birth outcome either use contraception consistently whose contraception fails emergency contraception purpose study understand willingness use among african american women recently adverse birth outcome healthy births healthy communities hbhc interconceptional care project iccp targeted high risk african american women two low income chicago neighborhoods recently adverse birth outcome aim hbhc iccp improve participants future birth outcomes providing medical social services helping women clarify reproductive life goals information participants pregnancy intentions willingness use measured interview shortly enrollment study women study either want become pregnant know wanted become pregnant within next years women times higher odds reporting willingness use compared women reported desire become pregnant within next years respectively aor essential part reproductive toolkit women high risk adverse birth outcomes intending pregnancy along reproductive life planning use effective contraception
despite compelling nature goodness fit empirical support lagged construct present study examined interactional approach measuring goodness fit prospectively explored associations mother child relationship quality child behaviour problems parenting stress across preschool period addition goodness fit might particularly important children developmental risk presence early developmental delay considered moderator goodness fit processes children without developmental delays mothers coded interacting lab child age months naturalistic home observations child ages months mothers also completed questionnaires child age months results highlight effects child developmental risk moderator mother child goodness fit processes across preschool period also evidence goodness fit maternal scaffolding child activity level months influenced mother child functioning months findings call precise models expanded developmental perspectives fully capture transactional dynamic nature goodness fit copyright john wiley sons ltd
dna vaccines offer many advantages anti tumor vaccine approaches due simplicity ease manufacturing safety results several clinical trials patients cancer demonstrated dna vaccines safe elicit immune responses however date dna vaccines progressed beyond phase clinical trial evaluation studies mechanism action dna vaccines terms antigen presenting cell types able directly present cross present dna encoded antigens activation innate immune responses due dna suggested opportunities increase immunogenicity vaccines addition studies mechanisms tumor resistance anti tumor vaccination suggested combination approaches increase anti tumor effect dna vaccines review focuses mechanisms action mechanisms resistance using dna vaccines information used improve anti tumor effect dna vaccines approaches specifically discussed context human prostate cancer disease dna vaccines continue explored treatments elsevier inc rights reserved
contactor kind low voltage electrical appliances large usage wide application frequent operation contactor life must long enough ensure reliable operation power system electrical life contactor key affect service life contactor mainly affected arc developed breaking closing course paper concentrates new type asynchronous modular contactor get contactor movement characteristics dynamic model electromagnetic system established matlab simulink according displacement curve contactor breaking process closing process planned thought closed loop control adjusting parameters pid controller enables contactor operate planning displacement curve addition achieve arc micro arc breaking bounce micro bounce closing displacement closed loop control system contactor designed
evidence supports establishment healthy feeding practices early life promote lifelong healthy eating patterns protective chronic disease obesity current early childhood obesity prevention interventions built extant understandings feeding practices relate infant cues hunger satiety insights regarding factors influence feeding behaviors early life may improve program designs outcomes four electronic databases searched peer reviewed qualitative studies published transitional infant feeding practice rationale developed countries reporting transparency potential bias assessed using consolidated criteria reporting qualitative research quality checklist thematic synthesis manuscripts identified three themes six sub themes theme infant physical cues behavioural cues focuses perceived signs readiness start solids feeding influence growth health happiness theme mother coping strategies knowledge skills focuses early survival infant family feeding satisfy hunger influence infant contentment sleep theme community pressure inconsistent advice highlights importance generational feeding conflicting feeding advice led many mothers adopt valued familial culturally established practices overall mothers pivotal feeding decisions satisfying infant needs reach good mothering status measured societal expectations highly valued lacked consideration nutrition obesity long term health maternal interpretation healthy infant feeding successful parenting need attention developing strategies support new families
study model presented obtain parameters penalty reward scheme prs performance based regulation pbr electricity distribution company edc using analytical hierarchy process ahp fuzzy means clustering fcm fcm algorithm similar companies categorized clusters using ahp score effective factor reliability index obtained model external factors affecting edcs performance considered reduce risk pbr implementation companies customers proposed model applied edcs iran results including ahp score parameters prs prs cost calculated elsevier ltd rights reserved
paper proposes decision making methodology using clustering methods fuzzy techniques determine optimal location distributed generation sources electrical distribution system based operational characteristics loss sensitivity factor voltage values nodes first found optimal distribution network partitioning using means clustering method used fuzzy techniques determine optimal location sources appropriate planning suggested method tested real rural distribution network nodes results demonstrate methodology successfully used determine optimal location electrical network without disrupting proper operation entire system
system identification engineering technique used build mathematical models dynamic systems observed data neuroscience research system identification used adapt robotic devices measurements apply perturbations techniques shown useful tools investigate brain mechanisms motor learning processes motor dysfunctions paper reviews application system identification motor behavioural data pertaining interruption specific neural mechanisms system identification technique could reveal adaptation generalisation functions neural mechanisms motor tasks fit experimental data measured robotic devices discrete state space model comparing constructed models persons neurological disabilities healthy control subjects system identification could used identify impaired abilities furthermore recent study indicated discrete state space model may predict recovery motor function stroke therefore suggest marriage robotic devices system identification comprise novel approach clinical assessment aid design patient rehabilitation protocols
electrical machine key component plug electric hybrid vehicle pev propulsion systems must designed high torque power densities wide speed range load capability high efficiency speeds low cost weight fast acceleration deceleration meeting performance reliability expectations paper overviews various technologies best candidates use pevs basic operational characteristics design features relative advantages disadvantages discussed compared pev propulsion systems latest future research directions ems pevs identified discussed literature concerned limitations capabilities finite element analysis magnetic equivalent circuit analysis design analysis pevs presented unfortunately papers give thorough comparisons experimental measurements simulation tools ems even fewer compare torque report torque show errors tests simulations saturation losses appear likely culprits nonlinear magnetic effects taken account including magnetic saturation eddy currents losses modeled care differences simulations tests typically order elsevier ltd rights reserved
disruptive behaviour disorders comprise diagnosis conduct disorder adults diagnosis antisocial personality disorder apd seen difficult treat disorder high risk persistent behavioral problems addition seen precursor antisocial personality disorder kretschmer dialectical behavior therapy dbt originally developed marsha linehan treatment borderline personality disorder core deficits emotion regulation disruptive behavior disorders dbt also increasingly recommended treatment apd review presents dbt adaptions forensic setting treatment apd clinical implications discussed
report describes case month old infant delivered hospital emergency physician intubated unclear unconscious state father reported child fallen couch ground consulted ophthalmologist reported venous stasis eyes including intraretinal preretinal bleeding four quadrants diffuse vitreous hemorrhage right eye temporal retinal wrinkling eyes based particular clinical findings shaken baby syndrome suspected report demonstrates importance recognizing correctly interpreting typical ophthalmological signs physical child abuse order detect prevent mistreatment children moreover increasing importance photographic documentation histological work findings forensic reasons emphasized
present cross sectional study tested portion tripartite model familial impacts self regulation morris reference social competence early adulthood young adults ages years female european american hispanic recruited mechanical turk local community participants responded anonymous online questionnaires self regulation parenting practices interpersonal competence sex peers romantic partners high parental acceptance low psychological control linked high levels self regulation high social competence relationship types associated high acceptance self regulation lifetime romantic relationship experience also covaried high romantic competence findings suggest tripartite model applicable interpersonal competence emerging adulthood elsevier inc rights reserved
paper describes computationally efficient approach mapping rotor power loss permanent magnet machines loss mapping methodology discussed utilizes small number time step finite element analyses feas determine parameters functional representation loss variation speed frequency stator current intended rapid evaluation machine performance entire torque speed envelope research focus placed field oriented controlled brushless machines surface mounted rotor construction although method could adapted rotor formats loss mapping procedure accounts axial segmentation array use equivalent electrical resistivity segmented array obtained three dimensional fea loss accurately mapped across full operational envelope including field weakened mode single four two dimensional time step feas proposed methodology validated slot pole surface mounted brushless machine design loss mapping procedure results closely agree computationally demanding alternative direct finite element prediction power loss undertaken machine operating points
patient reported outcomes perceptions critical overall efficacy acceptability surgical procedure outcomes patient satisfaction perceived success surgery adverse symptoms described detail following bariatric surgery associations predictors patient satisfaction defined study aimed examine long term outcomes perceptions laparoscopic adjustable gastric banding lagb conducted prospective study outcomes satiety adverse upper gastrointestinal symptoms well quality life subjective patient satisfaction lagb patients data collected years years post operatively one hundred sixty patients completed follow average age years total body weight loss satisfaction decreased significantly time points quality life reduced slightly across domains hunger scores remained low dysphagia score change significantly minimal change frequency regurgitation although significant increase patient assessment bothered regurgitation multivariate analysis identified increased awareness regurgitation principal driver reduced satisfaction weight loss satiety adverse symptoms demonstrated slight changes years post operatively despite overall satisfaction perception success procedure reduced markedly appeared mediated reduced tolerance adverse symptoms data inform follow practises aimed optimizing outcomes
prenatal development early childhood critical periods establishing tissue specific epigenome may profound impact health disease later life however epigenomic profiles birth early childhood remain largely unexplored focus report examine individual variation longitudinal pattern genome wide dna methylation levels birth first two years life black children males females enrolled boston medical center performed epigenomic mapping cord blood birth venous blood samples set children within first two years life using illumina infinium humanmethylation beadchip observed wide range inter individual variations genome wide methylation time point including lower levels cpg islands tss utr exon locations significantly higher levels cpg shores shelves tss gene body utr identified cpg sites significant intra individual longitudinal changes first two years life throughout genome specifically identified cpg sites males cpg sites females significant longitudinal changes defined statistical significance magnitude changes significant cpg sites appeared located within genes important biological functions including immunity inflammation studies needed replicate findings including analysis specific cell types link individual variations longitudinal changes specific health outcomes early childhood later life
paper proposes evaluate achievement main results operation intellectual mechatronic systems digital control obtained information effect respect common information requirements intellectual components considered basic information factor influences process mechatronic system designing therefore parameters accentuated help provide rather complete description processes used obtaining using systematic information within volume intellectual mechatronic system conformity degree control vector parameters synthesized system identification results current states selected information criterion control efficiency set expected probability values location parameter control object mechatronic system within required tolerances used formation possible states paper shows complex information description system used expedient use expert assessment selection probability allowable control vectors ensure system transfer favorable states approach made possible pinpoint main information technical specifications intellectual mechatronic system structural construction informational technical compatibility information matching components control object uncertainty state information vector information capacity mechatronic system control actions hierarchy entropic balance control process managerial resource mechatronic system functioning result informational effect control efficiency criterion probabilistic selection system states accordance fulfilled analysis possible note effective directions practical use proposed informational approach creation intellectual mechatronic system comparison alternative design solutions based analysis calculation assessments unconditional entropy control object system simulation aim accept final systematic option constructing digital controlling block created system complex application experts knowledge comprehensive introduction knowledge process mechatronic system designing
fully geometrically nonlinear finite element model developed using large rotation shell theory static analysis composite piezoelectric laminated thin walled structures proposed large rotation theory based first order shear deformation fosd hypothesis six independent kinematic parameters expressed five mechanical nodal degrees freedom dofs linear electro mechanically coupled constitutive equations constant electric field distribution thickness smart material layer considered eight node quadrilateral plate shell elements five mechanical dofs per node one electrical dof per smart material layer employed modeling present large rotation model implemented static analysis composite piezoelectric laminated plates shells equilibrium equation solved newton raphson algorithm system matrices updated every iteration results compared presented literature others calculated various simplified nonlinear shell theories indicate large rotation theory considered calculation displacements sensor output voltages smart structures undergoing large deflections since simplified nonlinear theories fail predict static response precisely many cases elsevier ltd rights reserved
solar thermal heat pump combisystem one many system alternatives market supplying domestic hot water dhw space heating dwellings study reference solar thermal air source heat pump combisystem defined modelled based products available market based results extensive literature survey several system variations investigated show influence heat pump cycle thermal storage system integration use electricity two houses climates zurich carcassonne singular economic cash flow analysis carried additional investment limit system variation determined range economic boundary conditions maximum extra investment cost system variant compared reference system give break even result year period results show variations electricity price affects additional investment limit far economic parameters several variants show potential achieving cost benefit potential varies lot depending load climate boundary conditions variants biggest difference electricity savings found zurich rather carcassonne explained larger heating load however three cases largest savings sfh house despite fact annual electricity use system much lower sfh house year compared year attributed fact cases operating level space heating circuit played significant role sfh house supplied degrees heating system sfh supplied degrees heating system elsevier ltd rights reserved
research summary past inquiry found implementing complex competitive repertoires diverse dynamic arrays actions challenging firms benefit examination antecedents outcomes complex competitive repertoires develops nuanced perspective data firms industries reveal complexity initially harms performance becomes positive factor except high levels use agency tournament theories respectively examine key governance mechanismsownership structure executive compensationhelp shape firms competitive repertoires find principals agency theory pay gap tournament theory important antecedents competitive complexity interaction exists wherein firms build especially complex repertoires influences strong managerial summary boxing fight always bigger stronger person even whomever throws punchesthe fight sometimes boxer unpredictable throwing uppercut opponent expected right hook similarly companies compete marketplace advantage afforded resources engage competitive activity also whose actions unpredictable study develop notion competitive complexity describes diversity changing nature company competitive moves implementing complex competitive repertoires painful short term done correctly help company performance long run copyright john wiley sons ltd
meta heuristic methods efficient search global solution complex problems better deterministic methods work applied novel meta heuristic harmony search algorithm technique used power network renewable energy injected validate robustness proposed approach proposed algorithm tested norm ieee bus three cases minimization fuel cost emission gaz integration renewable energy electrical network comparison results recent global optimization methods show superiority proposed approach confirm potential solving practical optimal power flow terms solution quality convergence characteristics elsevier ltd open access article license http creativecommons org licenses selection peer review responsibility euro mediterranean institute sustainable development eumisd
analyse velocity fluctuations inside coherent vortices generated result inverse cascade two dimensional turbulence finite box demonstrated kolokolov lebedev phys rev vol universal velocity profile established laurie phys rev len vol corresponds passive regime flow fluctuations property enables one calculate correlation functions velocity fluctuations universal region present results calculations demonstrate non trivial scaling structure function addition calculations reveal strong anisotropy structure function
standard model particle physics quarks anti quarks fractional charges equal electron charge large number experiments searching fractional charge particles using variety methods including ionization energy loss measurements collisions evidence found confirm existence free fractional charge particles leads quark confinement theory paper proposal search fractional charge particles presented based conservation law four momentum lorentz force law show power new strategy fully besiii detector simulated signal sample mixed fully simulated background sample analyzed lower signal cross section limits discover sigma signal function quark mass estimated background analysis result shows comparison ionization energy loss measurements advantage strategy identify fractional charge particles without using theoretical empirical formulae calculate expected observation values
based limited displacement theory iteration method took account characteristics concrete self anchored suspension bridge converted effects prestress shrinkage creep concrete equivalent loads made use finite element software ansys took concrete self anchored suspension bridge china example initial equilibrium state analysis type bridge static load carried paper order obtain main cable curve reasonable internal force girder hangers dead load results showed main cable curve smooth distribution hangers axial force uniform concrete girder certain amount compressive stress reserves
introduction abnormal thyroid function affect spermato genesis male infertility men aromatase deficiency cause infertility study aim investigate effect maternal hypothyroidism offspring testicular morphology cytochrome aromatase parom immunoreactivity materials methods eighteen wistar albino pregnant rats divided three groups namely groups hypothyroidism induced adding propyl thiouracil ptu drinking water hypothyroid mothers group given ptu days pregnancy group given ptu days prior pregnancy control mothers group given water hypothyroid control group mothers pups postnatal day pnd sacrificed determined immunoreactivity intensity parbm mrna levels pcr performed testis tissues elisa method used thyroid function tests tsh structure seminiferous tubule evaluated hematoxylin eosin staining results seen aromatase expression day old maternal hypothyroid groups similar one control group decline aromatase expression day old groups mrna determined tendency increase time groups increase significant tubule diameter johnsen testicular biopsy score diminished hypothyroid groups comparison control group conclusion changes occur early period testis development due maternal hypothyroidism negatively affect testis development next stages life situation leads decline aromatase expression following years
interactions decision variables typically make optimization problem challenging evolutionary algorithm solve exploratory landscape analysis ela techniques used quantify level variable interactions optimization problem however many studies using ela techniques investigate interactions limited combinatorial problems studies focused continuous variables paper propose novel ela measure quantify level variable interactions continuous optimization problems evaluated efficacy measure using suite benchmark problems consisting multidimensional continuous optimization functions differing levels variable interactions significantly results reveal measure robust accurately identify variable interactions show solution quality found correlated level variable interaction given problem finally present results simulation experiments illustrating measure embedded algorithm design framework enhanced algorithm achieves equal better results benchmark functions
remitted late life depression exhibits persistent cognitive impairments enhances risk dementia study aimed examine characteristics cognitive dysfunction remitted late life depression amnestic mild cognitive impairment mci remitted late life depression amnestic mci age education matched controls evaluated battery neuropsychological tests grouped executive function memory processing speed attention visuospatial domains compared control subjects amnestic mci individuals showed severe cognitive impairments domains remitted late life depression individuals performed worse executive function memory pattern cognitive profiles significantly differed remitted late life depression amnestic mci groups might mainly attributed worse impairments memory executive function amnestic mci individuals executive function core impaired cognitive domain mediating influence predictors cognitions remitted late life depression amnestic mci groups indicated possible etiopathogenic mechanism underlying conversion dementia
case chase year old boy followed primary care practice since age months born full term vaginal delivery weighing pounds ounces biological mother used heroin tobacco cocaine pregnancy weeks months spent time foster home provided limited attention nurturing age months entered loving foster home months adopted maternal history attention deficit hyperactivity disorder learning disability depression bipolar disorder substance abuse history autism cognitive disability chase received early intervention adoption specific concerns unknown time adoption delays gross motor fine motor skills nonverbal communication speech production familiar listeners find chase intelligible unfamiliar listeners understand chase says enjoys adopted mother imitating demonstrated significant anxiety play therapy difficulty paying attention multistep directions chase point wave difficulty following someone eyes see another person looking chase enjoys variety interests special fixation toy story characters chase initiate social interactions aggressive toward siblings oppositional toward parents aggressive school teachers note hyperactivity impulsivity chase bothered bright lights others making loud noises difficulty crowds chase reported difficulty transitioning activities year old visit well mother therapists note trouble following eyes referred neuro ophthalmologist evaluation showed chase able fix follow objects light peripheral vision normal pupils equal reactive without afferent pupillary defect normal visual tracking assessed pursuit saccades head jerking motions observed thought part chase attempts view objects gaze impersistence noted although clear due lack attention true inability maintain gaze direction instructed review school speech language report state intelligible occasional lip trills testing clinical evaluation language fundamentals shows mild delays receptive language especially require visual attention verbal motor production assessment children reveals focal oromotor control sequencing skills average groping asked imitate single oromotor nonspeech movements sequenced double oromotor nonspeech movements years returns follow outgoing imaginative eager play socialize makes eye contact always maintain asks responds questions appropriately able follow verbal directions verbal redirection interested toy story characters willing share plays toys chase speech predictable easy decode sound substitutions interview feel borderline cognitive abilities also demonstrates good eye contact lack visual gaze maintenance opposite pattern accustomed patients autism spectrum disorder next
evolution consumer electronics telecommunications computing empowered ambient intelligence emerging field research bringing new possible solutions many problems human life one technological assistance elders suffering cognitive deficit execution everyday life activities inside called smart home enable technology first challenge overcome recognition resident activities daily living adls problem consists inferring minimal set possible ongoing adls using templates plans activities defined library successfully achieve goal must exploit constraints different natures logical temporal etc order reject maximal number hypotheses however minority works exploited elementary spatial aspects related objects relations smart environment paper propose novel recognition model exploiting fundamental qualitative spatial reasoning approach egenhofer discriminate implausible ongoing activities furthermore model validated extensive testing realistic scenarios based clinical trials conducted laboratory normal impaired subjects
autoimmune diseases thyroid gland considered frequent cause thyroid gland disorders autoimmune thyroid diseases consist two subgroups autoimmune thyroiditis ait graves disease ait common human autoimmune disease infiltration thyroid gland cytotoxic taeurocells lead initial thyrotoxicosis und course hypothyroidism due destruction thyroid gland substitution levothyroxine indicated manifest hypothyroidism subclinical hypothyroidism increased thyroid antibodies intention normalizing serum thyroid stimulating hormone tsh graves disease characterized appearance stimulating tsh receptor antibodies leading hyperthyroidism endocrine ophthalmopathy may also occur ablative therapy radioiodine therapy thyroidectomy administered patients graves disease without remission least year antithyroid drug therapy
two assumptions guide current research first people desire see moral disposes make attributions enhance protect moral self image approached prosocial request people inclined attribute noncompliance external factors attributing compliance internal factors second attributions backfire put material test studies demonstrate people attribute refusal prosocial request external factor appointment excuse removed likely engage prosocial behavior never given excuse begin study shows people view morally reprehensible longer honor acceptance prosocial request accompanying external incentive removed refuse request unaccompanied external incentive study extends finding suggests people attribute derision behave prosocially internal factor despite presence external incentive likely continue behave prosocially external incentive removed external incentive ever offered research contributes understanding dynamics underlying perpetuation moral self regard suggests interventions increase prosocial behavior elsevier inc rights reserved
background irritable bowel syndrome ibs one common gastrointestinal disorders presenting clinical practice ibs functional bowel disorder abdominal pain discomfort associated change bowel habit features disordered defecation methods ibs candidates enrolled study using rome iii diagnostic criteria participants identified ibs diarrhoea dominant ibs constipation dominant well ibs mixed group participants randomly assigned intention treat potentiated clinoptilolite three times daily placebo primary endpoint determine whether patient experienced adequate relief symptoms results end treatment patients classified overall responders potentiated clinoptilolite placebo groups respectively week three treatment number weekly responders significantly higher potentiated clinoptilolite group compared placebo group week four treatment number weekly responders borderline significant higher potentiated clinoptilolite group secondary endpoints measured population size proved small realistically obtain statistical significance conclusion potentiated clinoptilolite shows clinical benefit tested larger clinical trials addition potentiated clinoptilolite also shows reduced symptoms ibd ibs respectively recommended clinical response dose variation also investigated designated populations ibs ibs patients
porous pavements easily retrofitted effective improving water quality hydrology prone clogging despite major determinant lifespan porous pavements limited information physical clogging processes systems aim study understand main physical processes govern physical clogging develop simple black box model predicts physical clogging key variables hypothesised influence clogging pavement design climate characteristics two compressed time scale laboratory experiments conducted years three common porous pavement types monolithic porous asphalt modular hydrapave monolithic permapave pavement design found important role clogging permapave clog even years operation simulated sub tropical brisbane australia climate porous asphalt hydrapave clogged years surface clogging geotextile clogging respectively system tested using two different dosing patterns continual wetting dry periods variable inflow rates drying periods representing natural conditions latter dosing method approximately doubled lifespan systems suggesting influence climate conditions clogging clogging found highly correlated cumulative volume flow rate simple black box regression model predicts physical clogging developed function cumulative volume brisbane climatic conditions however likely shape regression general could calibrated different climates future elsevier rights reserved
paper potential solar wind energy based distributed generation saudi arabia simultaneously analyzed aim maximizing utilization available resources begins analysis application potential wind solar energy resources various regions saudi arabia progress applications terms research planning exploitation wind solar energy resources presented assessment contribution energy sector saudi arabia conducted barriers challenges implementation systems country discussed suggested measures overcome challenges main findings huge potential wind solar resources applications country targeted wind solar capacity year saudi government expected provide full support form financial incentives solar wind energy projects order boost renewable energy development
fisheries provide nutrition livelihoods coastal populations many fisheries fully exploited lack approach analysing factors affect management tool performance conducted literature review studies assess fisheries characteristics affected management tool performance across small scale large scale fisheries defined success increased maintained abundance biomass reductions fishing mortality improvements population status literature covered narrow set biological factors also conducted expert elicitation create typology broader fishery characteristics enabling conditions design considerations affect performance literature suggested commonly used management tool region often successful although scale success varied management tools often deemed successful used combination particularly pairings tools controlled fishing mortality effort spatial management examples successful combinations use catch limits quotas limited entry marine protected areas effort restrictions common factors associated inadequate biological performance structural issues including poor design implementation expert derived typologies revealed strong local leadership high community involvement governance capacity common factors success across management tool categories input output technical measures degree importance varied results designed inform selection appropriate management tools based empirical data experience increase likelihood successful fisheries management
background disabilities arm shoulder hand dash questionnaire commonly used instrument assess outcomes basal joint arthritis bja however dash subject influence entire upper extremity purpose study aims develop validate disease specific questionnaire bja would sensitive changes thumb function pain correlate better objective subjective metrics patients methods thumb disability examination tdx developed patients presenting bja one two hospital based hand clinics enrolled validation study enrollment subjects given tdx dash visual analog pain scale activity vas surveys strength assessed patients receiving corticosteroid injection seen follow weeks underwent surgery seen months postoperatively groups given tdx dash vas scales follow results total subjects included analysis average tdx completion time seconds tdx correlated strongly vas scores baseline dash less strongly tip pinch measures tdx responsive injection surgical treatments bja dash yielding larger effect size standardized response mean instrument significantly correlate changes vas conclusion tdx reliable instrument assessing bja treatment outcomes bears less burden patients responsive symptomatic changes correlates better objective subjective measures dash
symmetric positive definite spd matrices form covariance matrices example ubiquitous machine learning applications however size grows quadratically respect number variables high dimensionality pose difficulty working may advantageous apply dimensionality reduction techniques principal component analysis pca canonical tool dimensionality reduction vector data maximizes preserved variance yet commonly used naive extensions pca matrices result sub optimal variance retention moreover applied spd matrices ignore geometric structure space spd matrices degrading performance paper develop new riemannian geometry based formulation pca spd matrices preserves data variance appropriately extending pca matrix data extends standard definition euclidean riemannian geometries experimentally demonstrate usefulness approach pre processing eeg signals texture image classification
light great interest interdisciplinary trauma research article explores philosophical literary concept cultural trauma perspective psychiatric psychoanalytical studies long term consequences holocaust extensive literature psychological effects final solution offers exceptional opportunity study aftermath extreme violence different subject positions including perspectives survivors perpetrators bystanders descendants moving epicenter historical event holocaust psychological periphery survey reveals much concept trauma changed course five decades result political cultural developments review literature also demonstrates none existing concepts holocaust trauma well suited explain effects holocaust representations individuals collectives encounter final solution media event educational entertainment purposes
risk taking influenced stress riskier decisions exposure acute stressor consecutively elevated cortisol levels brain cortisol acts two receptors different functional profiles glucocorticoid receptor mineralocorticoid receptor current study investigated effect stimulation risk taking behavior young healthy participants women mean age administered fludrocortisone agonist subjects placebo controlled design subsequently participants conducted established risk taking paradigm balloon analogue risk task bart also used two questionnaires assess risk taking decision behavior trait measures found treatment effect riskier decisions fludrocortisone group furthermore found sex effect risk taking men statistically significant interaction factors results indicate acute stimulation leads riskier decisions women men findings argue important role decision making processes elsevier ltd rights reserved
background ketamine increases blood pressure heart rate propofol anesthetic drug rapid recovery causes respiratory depression low heart rate low blood pressure combination ketamine propofol provides sedation analgesia rapid recovery hemodynamic stability minimal respiratory depression studies effect different concentrations ketofol amnesia children leukemia undergoing intrathecal injection chemotherapy drugs study investigated effect two concentrations ketofol midazolam amnesia patients materials methods randomized double blinded study conducted children aged years old referred shahid sadoughi hospital intrathecal chemotherapy july september patients received titrated injection solution containing combination one part ketamine ten parts propofol group one part ketamine five parts propofol midazolam group sedate fifth level ramsay sedation scale amnesia evaluated using visual recognition posters recall specific events drug side effects nausea vomiting hallucination allergies dizziness cough apnea also evaluated patients results significant difference two groups found regarding age weight value value running chi square revealed statistically different groups terms posters recognition recall specific events terms drug side effects two groups similar hallucination higher group value conclusion results showed ketofol superior comparison ketofol midazolam according less side effects similarity amnesia induction
automatic change detection one remote sensing applications received increasing attention last years however fully automatic solutions reach limitation one hand difficult design general decision criteria able select area changes images various acquisition conditions hand relevance changes may differ one user another letter introduce alternative change detection method based relevance feedback proposed algorithm iterative based query answer model asks user questions relevance targeted changes according answers updates change detection results method also based new formulation canonical correlation analysis cca referred context aware cca learns transformations map data different input spaces related multitemporal satellite images common latent space sensitive relevant changes resilient irrelevant ones cca transformations correspond optimum particular constrained maximization problem mixes alignment term context based regularization criterion particularity novel cca approach resides ability exploit spatial geometric context resulting better performances compared cca approaches shown experiments
whenmaking decisions everyday life often choose uncertain outcomes economic studies demonstrated healthy people tend prefer options known probabilities risk unknown probabilities ambiguity referred ambiguity aversion however remains unclear patients schizophrenia behave ambiguity despite growing evidence altered decision making uncertainty study combining economic tools functional magnetic resonance imaging fmri assessed attitudes toward risk ambiguity investigated neural correlates decision making risk ambiguity schizophrenia although significant difference attitudes risk observed patients schizophrenia chose ambiguity significantly often healthy controls attitudes risk ambiguity correlate across patients schizophrenia furthermore unlike healthy controls activation left lateral orbitofrontal cortex increased decision making ambiguity compared risk schizophrenia results suggest ambiguity aversion well established subjective bias attenuated patients schizophrenia highlighting need distinguish risk ambiguity assessing decision making situations findings comprising important clinical implications contribute improved understanding mechanisms underlying altered decision making patients schizophrenia elsevier rights reserved
context business process model notation bpmn facto standard business process modeling developed object management group support major organizations fields software engineering information systems despite wide use comes representing ubiquitous business processes business process modeling language lacking objective address bpmn deficiency representing ubiquitous business processes extend present ubpmn ubiquitous bpmn method first analyze modeling requirements representing ubiquitous business processes based requirements conservatively extend meta object facility meta model xml schema definition bpmn well extend notation extension call ubpmn follows outline set object management group bpmn results proposed ubpmn allows modeling ubiquitous business processes also lays groundwork potentially deploying variety ubiquitous computing technologies illustrate ubpmn capabilities benefits real life examples conclusion ubpmn extends bpmn new capabilities deal ubiquitous computing technologies elsevier rights reserved
onychomycosis one common diseases field dermatology refers fungal infection nail plate nail bed high incidence general population available treatment options onychomycosis limited use due side effects drug interactions contraindications necessitates application alternative treatment onychomycosis recent years lasers photodynamic therapy pdt recognized alternative treatment options previous studies found safe effective treatment modalities indication however results varied greatly vitro vivo outcomes contradictory present review studies related mechanism action lasers pdt treatment onychomycosis discussed focus find explanation contradictory results
paper first reviews theory active tendon control decentralized integral force feedback iff collocated displacement actuator force sensor formal proof formula giving maximum achievable damping provided first time next potential control strategy control suspension bridges active stay cables evaluated numerical model existing footbridge several configurations investigated active cables connect pylon deck deck catenary analysis confirms possible provide set targeted modes considerable amount damping reaching finally control strategy demonstrated experimentally laboratory mock equipped four control stay cables equipped piezoelectric actuators experimental results confirm excellent performance robustness control system good agreement predictions
runoff coefficients widely used diagnostic variable runoff generation process studies important input parameter hydrologic design many regions saudi arabia sufficient historical records detailed runoff information needed physically based distribution models department agriculture natural resources conservation service curve number usda nrcs method used study determining curve number runoff depth asir region saudi arabia runoff curve number determined based factors hydrologic soil group land use land cover slope gradient asir region saudi arabia using geographic information system gis region subjected previous studies concerning runoff generation rainwater harvesting using gis remote sensing arcgis global positioning system used develop soil map basis samples collected field survey soil textures identified used build map hydrological soil groups unsupervised supervised classification landsat images used generate land use land cover maps land cover distribution study area revealed largest class area barren sparsely vegetated land occupied study area total area followed shrubland cropland pasture mixed shrubland grassland grassland built land occupied slope map asir region generated digital elevation model gis technique used develop region based soil conservation service method annual runoff depth derived annual rainfall per pixel using raster calculator tool arcgis rainfall distribution study area showed wise identification suitable sites rainwater harvesting constructed dams located areas higher rainfall analysis also revealed annual runoff study area ranged total rainfall variation low year highest amount runoff generated saudi arabia runoff volume calculated entire region using previously developed runoff depth map basin areas results showed runoff volume asir region varied low maximum result revealed significant yearly amount runoff harvested use moreover calculated runoff depth area agreed actual dam capacities existing dams asir region approach applied regions saudi arabia rainwater harvesting groundwater recharge
context mechanisms mediating short long term improvements glucose homeostasis following bariatric metabolic surgery remain incompletely understood objective investigate whether reduction adipose tissue inflammation plays role metabolic improvements seen bariatric metabolic surgery short term longer term design fasting blood subcutaneous abdominal adipose tissue obtained one month months bariatric metabolic surgery individuals obesity insulin anti diabetes medication adipose tissue inflammation assessed combination whole tissue gene expression flow cytometry based quantification tissue leukocytes results one month surgery body weight reduced improvements glucose tolerance reflected decrease area curve auc glucose oral glucose tolerance tests mmol min enhanced pancreatic beta cell function insulinogenic index pmol mmol change estimated insulin sensitivity matsuda insulin sensitivity index isi furthermore although biomarkers systemic inflammation pro inflammatory gene expression adipose tissue remained unchanged number neutrophils increased adipose tissue fold less substantial increases leukocyte populations month follow visit body weight reduced relative baseline glucose tolerance improved auc glucose along estimated insulin sensitivity matsuda isi addition improvements systemic inflammation reflected reductions circulating reactive protein crp increased serum adiponectin however leukocyte infiltration adipose tissue remained elevated relative baseline pro inflammatory cytokine mrna expression unchanged adiponectin mrna expression trended downward conclusion short longer term metabolic improvements following bariatric metabolic surgery occur without significant reductions measures adipose tissue inflammation assessed measuring expression genes encoding key mediators inflammation flow cytometric immunophenotyping quantification adipose tissue leukocytes elsevier inc rights reserved
objectiveto describe diagnostic types characteristics headaches soldiers mild traumatic brain injury wars afghanistan iraq backgroundpersistent post traumatic headache interferes returns activity duty commonly cited headache diagnosis concussion migraine hypothesize headache diagnosis type migraine sufficient predict relationships occupational outcomes concussion methodsthe study sample consisted new patients referred headache evaluation brain injury center womack army medical center year time period design retrospective observational clinical data reported included demographics causes injury headache characteristics headache diagnosis type reviewing records retention severance military service primary occupational outcome measure departure service due medical cause determined medical evaluation board meb primary outcome measure test strength association leaving service meb headache characteristics diagnosis resultsa total patients male concussion described distinct headache types common migraine trigeminal autonomic cephalalgia total patients remained active duty continuous headache type present patients remained active duty patients continuous non continuous headache remained active duty therefore report continuous headache regardless diagnosis type associated negative occupational outcomes regardless headache duration headache diagnosis type alone associated soldiers separations service conclusionspersistent post traumatic headache likely present continuous pain migraine common primary diagnosis type presence continuous headache strongly associated negative occupational outcomes primary headache diagnosis type headache characteristics therefore may important diagnosis type determining active duty status prospective research indicated
study laser metal deposition lmd additive manufacturing used deposit pure inconel alloy tic inconel composites different starting sizes tic particles respectively influence additive tic particle original size constitutional phases microstructural features mechanical properties lmd processed parts studied incorporation tic particles significantly changed prominent texture matrix phase bottom side parts deposited track showed mostly columnar dendrites cellular dendrites prevailing microstructure central zone deposited track nano tic particles added columnar dendrites observed solidified molten pool incorporation nano tic particles induced formation significantly refined columnar dendrites secondary dendrite arms developed considerably well micro tic particles added columnar dendrites relatively coarsened highly degenerated secondary dendrite growth entirely suppressed cellular dendrites obviously refined additive tic particles nano tic particles added reinforce inconel significantly improved microhardness tensile property wear property obtained without sacrificing ductility composites
archival samples european ancestry subjects light eyed individuals found consume alcohol dark eyed individuals published population based studies directly tested association alcohol dependence eye color hypothesized light eyed individuals higher prevalence dark eyed individuals mixture model used select homogeneous sample european americans control population stratification quality control conducted association study using logistic regression adjusting confounders age sex genetic ancestry found evidence association blue eye color odds ratio supporting light eye color risk factor relative brown eye color network based analyses revealed statistically significant number genetic interactions eye color genes associated genes found evidence linkage disequilibrium associated gaba receptor gene cluster gabrb gabrg eye color genes oca herc well associated grm pigmentation associated tyr population phenotype network linkage disequilibrium analyses support association blue eye color although controlled stratification exclude underlying occult stratification contributor observation although replication needed findings suggest eye pigmentation information may useful research characterization association may unravel new etiological factors wiley periodicals inc
impaired social functioning hallmark major psychiatric disorders purpose study detect disorder specific factor social dysfunction among patients major psychiatric disorders psy including schizophrenia scz bipolar disorder bip major depressive disorder mdd social functioning assessed patients scz bip mdd healthy controls using social functioning scale sfs compared scz bip mdd patient groups showed lower total sfs scores differences total scores social functioning observed patient groups next investigated seven subscales sfs among psy observed significant diagnostic effects subscales sfs notably patients scz poorer interpersonal communication patients mdd furthermore poorer interpersonal communication score significantly correlated increase schizotypal personality traits assessed schizotypal personality questionnaire spq although differences overall social functioning among psy disorder specific factors interpersonal communication evident scz correlation poor interpersonal communication increase schizotypal traits suggests poor interpersonal communication may intermediate phenotype scz
although challenges autistic students face adapting college often pronounced similar challenges students disabilities face difficulties social interaction self advocacy executive functioning however extant evaluations services autistic college students limited despite emerging literature examining supports college students range disabilities given many autistic students self identify autistic college consequently might avoid autism specific services autistic students might benefit services designed support broad range neurodiverse students services structured according principles universal design order develop services assessed self reported needs autistic college students peers disabilities guided needs assessments feedback students developed evaluated two semesters mentor led group programming autistic college students students disabilities first semester program focused social skills receiving feedback participants curriculum second semester focused self advocacy participation social skills groups associated decreased anxiety autism symptoms participation self advocacy groups associated increased perceived social support friends academic self efficacy accurate definitions self advocacy research suggests supports neurodiverse college students developed input include opportunities engage diverse peers
functional renormalisation group frg evolved versatile tool condensed matter theory studying important aspects correlated electron systems practical applications method often involve high numerical effort motivating question far high performance computing hpc leverage approach work report multi level parallelisation underlying computational machinery show speed code several orders magnitude turn extend applicability method otherwise inaccessible cases exploit three levels parallelisation distributed computing means message passing mpi shared memory computing using openmp vectorisation means simd units single instruction multiple data results provided two distinct high performance computing hpc platforms namely ibm based bluegene system juqueen intel sandy bridge based development cluster discuss certain issues obstacles overcome course adapting code importantly conclude vast improvement actually accomplished introducing moderate changes code strategy may serve guideline researcher likewise improve efficiency codes elsevier rights reserved
aimto report analysis concept leading change backgroundnurses called lead change advance health individuals populations systems conceptual clarity leading change context nursing healthcare systems provides empirical direction future research theory development advance science leadership studies nursing designconcept analysis data sourcescinahl pubmed psycinfo psychology behavioral sciences collection health business elite business source premier databases searched using terms leading change transformation reform leadership change literature published english fields nursing medicine organizational studies business education psychology sociology included methodswalker avant method used identify descriptions antecedents consequences empirical referents concept model related contrary cases developed resultsfive defining attributes leading change identified individual collective leadership operational support fostering relationships organizational learning balance antecedents external internal driving forces organizational readiness consequences leading change included improved organizational performance outcomes new organizational culture values conclusiona theoretical definition conceptual model leading change developed future studies use test model may contribute refinement middle range theory advance nursing leadership research education empirically derived interventions prepare enable nurses lead change advance health may realized
downhill conveyors important potential energy sources within conveyor belt systems cbss energy captured using regenerative drives paper presents generic optimisation model energy management cbss downhill conveyors optimisation model able optimally schedule three configurations case study cbs connected grid operated time use tariff three suggested drive configurations showcase potential energy savings incomes obtained implementing variable speed control internal use downhill conveyor energy export energy grid results show cbs daily energy consumption kwh reconfigured controlled reduce consumption made generate kwh depending configuration analysis investment three configurations assessed using life cycle cost payback period pbp daily operation simulation results show use regenerative drives variable speed control able provide energy savings cbss cost analysis shows configuration enables sale energy grid profitable arrangement case study plant consideration sensitivity analysis indicates pbps sensitive annual electricity price increases changes discount rate combining regenerative drives optimal operation cbs generates energy savings give attractive pbps less years
following idea spectral graph theory give several characterizations finite one peak posets almost critical quadratic tits form bari applying linear algebra methods combinatorial algorithms old idea ovsienko recent results bondarenko stepochkina study mainly motivated important application quadratic tits form poset constructing linear algebra invariants measure geometric complexity nazarova roiter matrix problems field particular study inspired well known result drozd explained introduction one main results asserts given finite poset boolean unique maximal element bari almost critical form capi non negative subgroup ker capi element capi generated vector equal equal euclidean diagram delta invertible matrix cap cap cap element tits matrix matrix one posets listed paper particular get alternative way list critical posets form presented bondarenko stepochkina determine coxeter euclidean types one peak posets element cap critical exceptional posets element cap almost critical critical lists obtained using computer algebra tools mainly symbolic computation maple numeric computation elsevier inc rights reserved
use fuzzy analytic hierarchical process fahp fuzzy transformation matrix ftm research takes policies related intelligent green building promoted taiwan subjects extract collective intelligence senior domain experts evaluate contribution weight ranking policy measures achieve policy goals addition implementation policy measures green building label intelligent building label green building material label year period growth decline evaluation cases analyzed testify feasibility policy evaluation method proposed results show use fahp ftm extract collective intelligence senior experts establish policy evaluation method reference value additional building bulk incentive private building mandatory control public building mandatory incorporation green public purchase green building material effective policy measures taiwan implementation control measures stage design planning new buildings superior control stage operation management effectiveness elsevier rights reserved
along recent real estate development major cities australia sustainable construction one measures implemented reduce negative impacts construction industry environment society economy however lack detailed review kind important studies critical australian future endeavour paper presents systematic review large scale earthwork project discusses concerns examples three dimensions firstly environment aspect factors including remediation various type contaminated general waste management runoff water dust control noise vibration monitoring showcased secondly society aspect factors including innovated wheel wash facility cctv system drainage protection wildlife protection mentioned lastly economy aspect factors including integrated weighbridge management system recycling waste water recycling rock demonstrated research identifies future opportunities innovation evaluation system project design framework finance analysis model potentially integration sustainable construction practise australian code practice authors published elsevier ltd
peacehealth senior health wellness center shwc provides primary care coordinated geriatricians interdisciplinary office practice team addresses multiple needs geriatric patients shwc hospital outpatient clinic operated component integrated health system focused care frail elders multiple interacting chronic conditions management chronic disease healthier older population based chronic care model shwc strives enhance coordination continuity along continuum care including outpatient inpatient skilled nursing long term care home care services development patient centered approach used identify senior service needs model emphasizes team development integration evidence based geriatric care site based care coordination longer appointment times high touch service qualities utilization electronic medical record across care settings prevention wellness orientation collection services addresses interrelationships senior issues including nutrition social support spiritual support caregiver support physical activity medications chronic disease shwc provides access environment sensitive special needs seniors staff trained meet needs shwc business model attempts improve access quality care seniors mostly noncapitated healthcare setting also attempting remain financially viable
objective order guide curricular innovation looked feasibility utility performing targeted needs assessment communication skills pgy internal medicine residents continuity clinic utilizing faculty direct observation validated instrument communication skills evaluation methods convenience sample pgy residents emory university school medicine residency program invited participate using segue framework checklist medical communication tasks faculty assessed residents clinic encounter results thirty pgy residents assessed segue results indicate residents likely maintain patient privacy greet patient appropriately check clarify information residents least likely acknowledge waiting time explore psychosocial emotional factors outline agenda visit conclusion segue framework feasible tool evaluate communication skills residents clinic setting many pgy residents large urban practice elicit important psychosocial information outpatient clinic visits practice implications observation evaluation residents communication skills needed emphasis building skills understand patient perspective elsevier ireland ltd rights reserved
recycling braking energy significant improve total energy efficiency electric vehicles evs moreover braking safety must maintained complex conditions actuator electric traction motor much better features internal combustion engine faster torque response capability energy feedback perspective energy efficiency safety highlighting regenerative braking meaningful challenging problem paper braking system using electric motors generators actuators investigated energy may potentially fed back onboard energy storage system ess much possible energy may recovered ess analyzed tomaintain stability improve performance regenerative braking unknown tire road conditions knowledge based methodology hierarchical control structure proposed maximum adhesion force motor reference torque mrt determined online proposed methodology avoids complex determination optimumslip ratio acquiring nearly optimumantiskid braking performance simulation experiment carried validate effectiveness
bayesian nonparametric approaches recently introduced system identification scenario impulse response modeled realization zero mean gaussian process whose covariance kernel estimated data scheme quality estimates crucially depends parametrization covariance gaussian process family kernels shown particularly effective system identification framework family diagonal correlated kernels maximum entropy properties related family kernels tuned correlated kernels recently pointed literature technical note show maximum entropy properties indeed extend whole family kernels maximum entropy interpretation exploited conjunction results matrix completion problems graphical models literature shed light structure kernel particular prove kernel admits closed form factorization inverse determinant results exploited improve numerical stability reduce computational complexity associated computation estimator
paper fully cmos implementation current mode full wave precision rectifier presented structure generally based recently presented lazzaro winner takes wta circuit rectifier implemented using cmos technology behavior verified spice simulation results shown feasibility process signals frequencies mhz
background repeated measurements hepatitis virus hcv rna levels antiviral therapy recommended monitor treatment efficacy adherence throughout direct antiviral agent daa approval studies hcv rna cutoffs endpoints established cobas tagman assay use high pure system hps ctm different assays used clinical practice may yield different quantitative results possibly impact treatment decisions objectives concordance fully automated cobas ampliprep cobas tagman assay cap ctm hps ctm ability predict response daa treatment ledipasvir sofosbuvir assessed cirrhotic patients hcv genotype infection failed prior treatment protease inhibitor based regimens study design serum samples patients treated phase sirius study collected baseline antiviral therapy weeks tested parallel assays results mean difference hps ctm cap ctm baseline logio hcv rna discordant results observed samples collected treatment weeks greatest differences observed weeks respectively undetectable hcv rna svr rates study significantly different patients detectable undetectable hcv rna according assays weeks antiviral therapy conclusions cap ctm hps ctm showed significantly different response rates early stages ledipasvir sofosbuvir treatment however treatment response predictive svr either assay indicating determination treatment hcv rna levels may useful guide treatment decisions elsevier rights reserved
conclusion multimodal diagnostic algorithm simple diagnostic tool pre operative assessment submandibular masses enables one stage surgical concepts background pre operative assessment submandibular masses major clinical impact study assesses diagnostic utility newly introduced diagnostic algorithm differentiation submandibular masses based epidemiological mode ultrasonographic data methods one hundred eighty eight patients submandibular triangle masses included epidemiological ultrasonographic data consecutively included patients assessed structured multimodal algorithm diagnostic algorithm prospectively validated patients results single epidemiological ultrasonographic data reliably predict lesional entity multimodal diagnostic algorithm achieved diagnostic sensitivity specificity sialolithiasis benign submandibular gland diseases bsd nodal lymphoma unspecific lymphadenitis carcinomas reduced sensitivity bsd specificity carcinomas increased intra operative fresh frozen section patients suspected bsd
cell cell transmission protein aggregates emerging theme neurodegenerative disease analyze dipeptide repeat dpr proteins form neuronal inclusions patients hexanucleotide repeat expansion corf common known cause amyotrophic lateral sclerosis als frontotemporal lobar degeneration ftld sense antisense transcripts repeat translated repeat associated non atg ran translation reading frames five aggregating dpr proteins show hydrophobic dpr proteins poly poly poly transmitted cells using culture assays cell extracts moreover uptake expression poly induces nuclear rna foci expressing cells patient fibroblasts suggesting unexpected positive feedback loop exposure recombinant poly cerebellar extracts corf patients increases repeat rna levels seeds aggregation dpr proteins receiver cells expressing treatment anti antibodies inhibits intracellular poly aggregation blocks seeding activity corf brain extracts poly directed immunotherapy may thus reduce dpr aggregation disease progression corf als ftd
integrated design platform newer type machines presented work machine parameters evaluated using developed modelling tool machine parameters machine modelled using computer aided tool designed machine brought simulation tool perform electromagnetic electromechanical analysis simulation conditions setting performed setup materials meshes rotational speed excitation circuit electromagnetic analysis carried predict behavior machine based movement flux machines besides electromechanical analysis carried analyse speed torque characteristic current torque characteristic phase angle torque characteristic results analysed designed machine used generate block function compatible matlab simulink tool dynamic operational characteristics allows integration existing drive system new machines designed modelling tool example machine design presented validate usage tool
parkinson disease common neurodegenerative disorder characterized progressive selective death dopaminergic neurons multifunctional neuropeptide orexin involved many biological events body shown orexin protective effects neurodegenerative disease however cellular mechanisms yet fully clarified investigated intracellular signaling pathway orexin neuroprotection hydroxydopamine ohda induced syh cells damage vitro model cells incubated ohda viability examined dimethyl thiazolyl diphenyl tetrazolium bromide mtt assay mitochondrial membrane potential intracellular calcium measured fluorescent probes western blotting also used determine cyclooxygenase type cox nuclear factor erythroid related factor nrf hsp protein levels data showed ohda decreasing effects cell viability nrf hsp protein expression increases level mitochondrial membrane potential intracellular calcium cox protein orexin significantly attenuated ohda induced cell damage furthermore orexin significantly prevented mentioned effects ohda syy cells orexin receptor antagonist pkc kinase pik inhibitors chelerythrin respectively could suppress orexin neuroprotective effect contrast blockage pka selective inhibitor effects orexin protection results suggest orexin protective effects ohda induced neurotoxicity performed via receptors pkc pik signaling pathways
purpose purpose study examine associations patients informal caregivers psychosocial resiliency factors partners emotion domains distress anxiety depression anger admission neuroscience intensive care unit neuro icu materials methods eighty three dyads patients total informal caregivers total participated observational cross sectional study self reporting demographics measures resiliency factors mindfulness cognitive affective mindfulness scale revised coping measure coping status intimate bond intimate bond measure self efficacy patients general self efficacy scale caregivers revised caregiver self efficacy scale emotion domains emotion thermometers within weeks neuro icu admission results differences patients caregivers levels psychosocial resiliency distress anxiety patients reported greater depression anger relative caregivers overall roughly half patients caregivers reported clinically significant emotional distress patients caregivers psychosocial resiliency factors associated partner emotion domains conclusions findings high distress among patients caregivers admission emphasize importance attending mental health patients caregivers neuro icu modifiable psychosocial resiliency factors associated emotion domains patients caregivers interventions enhance factors may ameliorate emotional distress among vulnerable populations elsevier inc rights reserved
beyond current emphasis body mass index bmi unknown whether breast cancer risk differs metabolically healthy unhealthy normal weight overweight obese women sister study nationwide prospective cohort study data came cohort participants aged years enrolled cox proportional hazards models used estimate multivariable adjusted hazard ratios confidence intervals cis breast cancer risk metabolic abnormalities considered included high waist circumference elevated blood pressure antihypertensive medication previously diagnosed diabetes antidiabetic drug treatment cholesterol lowering medication use follow mean years invasive breast cancers diagnosed least year enrollment compared women bmi metabolic abnormalities metabolically healthy normal weight phenotype women bmi metabolic abnormality metabolically unhealthy normal weight phenotype increased risk postmenopausal breast cancer women bmi metabolic abnormalities metabolically healthy overweight obese phenotype furthermore risk postmenopausal breast cancer consistently elevated women normal bmi central obesity normal weight central obesity phenotype regardless criterion used define central obesity waist circumference waist circumference waist hip ratio respectively inverse association premenopausal breast cancer metabolically healthy overweight obese phenotype findings suggest postmenopausal women metabolically unhealthy central adiposity may increased risk breast cancer despite normal bmi new association metabolic factors hypertension diabetes high cholesterol central obesity risk breast cancer differ normal weight overweight obese women study authors found normal weight postmenopausal women metabolically unhealthy may increased risk breast cancer despite normal body mass index overweight obese women metabolically healthy findings suggest targeting metabolic abnormalities may provide additional targets prevention strategies reduce breast cancer risk
background evaluate immunomodulating clinical effects nilotinib tyrosine kinase inhibitor proof concept study spondyloarthritis spa assessing mast cell potential novel therapeutic target disease methods twenty eight patients active peripheral pspa axial spa axspa included randomized double blind placebo controlled clinical trial trial registration trialregister ntr patients treated nilotinib placebo weeks followed open label extension another weeks paired synovial tissue biopsies serum sampling assessment clinical symptoms performed serially results pspa synovial inflammation appeared diminish weeks nilotinib treatment evidenced histopathology decrease number infiltrating macrophages mast cells compared placebo mrna expression kit mast cell marker pro inflammatory cytokines reduced reduction synovial inflammation paralleled decrease serum biomarkers inflammation reactive protein calprotectin also clinical parameters patient global assessment disease activity ankylosing spondylitis disease activity score showed improvement upon weeks nilotinib placebo treatment improvement augmented week contrast pspa neither serum biomarkers inflammation clinical parameters improved upon nilotinib treatment axspa trial one serious adverse event occurred considered unrelated study drug conclusions small proof concept study suggests nilotinib treatment modulates inflammation clinical symptoms pspa similar effect seen axspa
arc flash protection around electrical process equipment paramount industrial setting especially petroleum chemical industries laboratory testing motor terminal box structural integrity rupture panel efficacy fault carried simple calculations made validate design compared test results simulation results compared test data simple calculations shown robust simulation techniques needed accurately capture physics arc flash make simulation feasible tool design recommendations made designing testing future terminal boxes
infants risk autism spectrum disorders asd may difficulty integrating smiles initiating joint attention ija bids specific ija pattern anticipatory smiling may communicate preexisting positive affect infant smiles object turns smile toward social partner compared development anticipatory smiling months infant siblings children asd high risk siblings without asd low risk siblings high risk siblings produced less anticipatory smiling low risk siblings suggesting early differences communicating preexisting positive affect early anticipatory smiling distinguished risk groups ija accompanied smiling best predicted later severity asd related behavioral characteristics among high risk siblings high risk infants appear show lower levels motivation share positive affect others however facility initiating joint attention absence clear index positive affective motivation appears central prediction asd symptoms
university hospital zurich offers text based medical online consultation service public since users asked health questions anonymously tele doctors study focused characteristics male enquirers intimate health problems content questions medical advice given tele doctors rating service prove benefit online service medical laymen retrospective study included enquiries using international classification diseases international classification primary care codes relevant intimate sexual health problems men professional text analysis program maxqda supported content analysis based procedure inductive category development described mayring average age years enquirers comorbidity first time consulted doctor asked specific single intimate health issue important organ concern penis overall asked sexually transmitted diseases doctor visit recommended clarify health issue rating problem solving good service mainly used younger men without comorbidity previous contact doctor regard intimate health problem anonymous setting teleconsultation provided men individual professional medical advice decision support teleconsultation suggested empower patients developing health literacy
recent studies examined non suicidal self injury community clinical samples published research non suicidal self injury individuals autism spectrum disorder lack research surprising since individuals autism spectrum disorder high rates risk factors non suicidal self injury including depression poor emotion regulation skills using online survey examined non suicidal self injury methods frequency severity functions initial motivations adults autism spectrum disorder also compared non suicidal self injury characteristics gender matched group adults without autism spectrum disorder participants autism spectrum disorder reported history non suicidal self injury proportion higher non suicidal self injury rates previously reported college students adult community samples adolescents autism spectrum disorder suggests adults autism spectrum disorder increased risk engaging non suicidal self injury women autism spectrum disorder significantly likely endorse non suicidal self injury relative men autism spectrum disorder history non suicidal self injury related current depression emotion dysregulation participants autism spectrum disorder non suicidal self injury characteristics among adults autism spectrum disorder similar non suicidal self injury adults without autism spectrum disorder preliminary findings highlight need increased awareness research non suicidal self injury within autism spectrum disorder
article describes design phase development practical application smart object integrated desk lamp called smart lamp useful optimize indoor thermal comfort energy savings two important workplace issues comfort workers consumption building strongly affect economic balance company smart lamp built using microcontroller integrated temperature relative humidity sensor modules printer smart device similar desk lamps usually found offices allows one adjust indoor thermal comfort interacting directly air conditioner construction phase smart lamp installed office normally occupied four workers evaluate indoor thermal comfort cooling consumption summer results showed application smart lamp effectively reduced energy consumption optimizing thermal comfort use diy approach combined read write functionality websites blog social platforms also allowed customize improve share reproduce interconnect technologies anybody could use occupied environment
repetitive control strategies commonly applied pulse width modulated pwm voltage source inverters vsis many industrial applications paper presents repetitive controller voltage harmonic mitigation vsi based islanded microgrids phase delay overall control system delay caused digital duty cycle calculation pwm generation repetitive controller compensated elaborately designed phase lead filters order prevent control performance deterioration system instability nevertheless quantificational analysis practical design time advance unit filters hardly found existing literature works view paper proposes explicit analysis phase lead filters novel design method time advance unit repetitive controllers ensure system stability moreover help proposed method overall system stability margin predictable improved controller performance achieved well proposed method implemented experimentally show accurate stability margin calculation well excellent steady state dynamic performances repetitive control scheme
delayed resonators refer special type active vibration absorber system intentionally delayed feedback control used bring absorber sub structure resonance turn canceling vibrations primary structure far theory applied traditional mechanical vibration absorbers proof masses study proposes new venue based vibration control using piezoelectric networks inherent electro mechanical coupling piezoelectric materials enabled use electrical circuits absorb vibrations mechanical structures principles applied create resonating electrical circuit offers ideal vibration absorption performance experimental studies also presented demonstrate results ifac international federation automatic control hosting elsevier ltd rights reserved
modern botnets zeus conficker commonly utilize technique called domain fluxing domain generation algorithm generate large number pseudo random domain names pdns dynamically botnet operators control bots botnets becoming one serious threats internet security global scale prevent destructive action one pressing issues today paper focus detecting domain flux botnets within monitored network based domain name system dns traffic features method passively captures dns traffic gateway monitored network extracts key features identify pdn based examining analyzing large number legitimate domains well pdn generated botnets discovered discernible bias rules constructing domain names therefore introduce methodology analyzes dns traffic extract length expected value distinguish domain name generated humans bots order evaluate effectiveness proposed approach various machine learning algorithms applied train predictive models detection system proposed scheme implemented tested real local area network experimental results show proposed method achieves highest detective efficiency decision tree algorithms average overall accuracy false positive rate copyright john wiley sons ltd
recent years green building become flagship sustainable development leading number published works topic paper examines research trend construction management analyzing selected research papers published selected journals end august analysis conducted terms number annual research publications contributions made various countries institutions authors research topics covered analysis reveals increasing research interest recent times implying importance attached construction industry accelerating findings also indicate studied period researchers developed economies hong kong singapore italy australia contributed promoting research developing countries china egypt colombia also made good efforts promote research research topics covered tend focus project delivery developments certifications energy performance advanced technologies research gaps discussed directions future research proposed study may serve valuable platform industry practitioners researchers appreciate research trends developments elsevier ltd rights reserved
recently graph based dimensionality reduction methods attracted much attention due widely applications many practical tasks image classification data clustering however inappropriate graph accurately reflect underlying structure distribution input data dramatically deteriorate performances methods paper propose novel algorithm termed locality constrained graph optimization dimensionality reduction godr address limitations existing graph based dimensionality reduction methods firstly unlike graph based dimensionality reduction methods graphs constructed advance kept unchanged dimensionality reduction godr combines graph optimization projection matrix learning joint framework therefore graph proposed algorithm adaptively updated procedure dimensionality reduction secondly introducing locality constraints godr local information high dimensional input data discovered well preserved makes proposed algorithm distinct graph optimization based dimensionality reduction methods moreover effective updating scheme also provided solve proposed godr extensive experiments two uci five image databases conducted demonstrate effectiveness algorithm experimental results indicate proposed godr outperforms related methods elsevier rights reserved
paper presents design principles highly efficient legged robots implementation principles design mit cheetah analysis high speed trotting experimental results design principles derived analyzing three major energy loss mechanisms locomotion heat losses actuators friction losses transmission interaction losses caused interface system environment four design principles minimize losses discussed employment high torque density motors energy regenerative electronic system low loss transmission low leg inertia principles implemented design mit cheetah major design features large gap diameter motors regenerative electric motor drivers single stage low gear transmission dual coaxial motors composite legs differential actuated spine experimental results fast trotting presented robot runs total power consumption battery pack resulted total cost transport rivals running animals scale total energy consumption attributed heat loss motor remaining used mechanical work dissipated interaction loss well friction losses joint transmission
engineering designs typically constrained requirements specifications design analogy performance parameters system apps project seeks provide engineers means transform product requirements specifications functional analogies apps employs design analogy dba via critical functionality engineering performance parameters specifications produce functional alternative options design engineers repositories databases provide structured storage information retrieval users systemic manner apps utilizes repository store analogy entries capable polled developed algorithm analogous matches formulated weighting scheme algorithm research investigates structures three alternative repositories current apps database interface algorithm design engineer architecture repository discussed example entries rationale inclusion
paper proposes trajectory vehicles encountering incident site offers six indices evaluating impact incident traffic patterns based global positioning system gps data traffic incidents major contributors non recurrent delays mitigating effects necessitates appropriate efficient allocation equipment personnel clearance plan reliable real time traffic impact evaluations essential prerequisites task existing duration models however developed basis local data may portable inconsistent data structures differing local conditions method proposed paper limited shortcomings based purely classical traffic flow theory proposed trajectory calibrated validated using real world taxi gps data accident data hong kong proposed indices severity estimated analysing calibrated trajectories results reveal proposed indices reconstruct scene incident site proposed method promising widespread use gps technology potential benefits method incident management realised
focus work model hydrodeoxygenation process produce renewable jet fuel products low input oilseeds specifically camelina carinata non edible oil used cooking oil uco taking account fatty acid compositions incorporating stoichiometric hydrodeoxygenation reactions methodology provides insight effect feedstock composition hydrodeoxygenation reactions upon product yields product distribution hydrogen consumption process utilities resulting product slates hydrogen gas utility demands specific camelina carinata uco feedstocks yield kerosene range alkanes ranged incoming oil diesel range alkanes naphtha liquefied petroleum gas depending upon fatty acid composition hydrogen consumption rate ranged per tonne incoming oil depending upon degree bond unsaturation thermal energy demand tonne oil processing used cooking oil versus tonne oil carinata camelina respectively owing additional energy required oil extraction electricity demand kwh tonne oil uco versus kwh tonne oil carinata camelina elsevier ltd rights reserved
paper presents three approaches frequency compensation chopper offset stabilized amplifiers symmetrical passive notch filter two cutoff frequencies filter two cutoff frequencies chopping frequency fifth harmonic chopping frequency frequency compensation network connected either input notch filter output two sections large signal transient response evaluated terms overshoot undershoot settling time three circuits using techniques fabricated evaluated approach uses frequency compensation network connected sections filter best results except chopping ripple rejection
objective study investigated whether racial disparities depression present hurricane katrina method data gathered new orleans residents present hurricane katrina struck returned new orleans following year multiple logistic regression models evaluated racial differences screening positive depression score center epidemiologic studies depression scale explored whether differential vulnerability prehurricane physical mental health functioning education level differential exposure hurricane related stressors loss social support moderated reduced association race depression results univariate logistic regression analysis showed odds screening positive depression higher african americans caucasians odds ratio however controlling simultaneously sociodemographic characteristics preexisting vulnerabilities social support trauma specific factors race longer significant correlate screening positive depression conclusions racial disparity postdisaster depression seems confounded sociodemographic characteristics preexisting vulnerabilities social support trauma specific factors nonetheless even adjusting factors nonsignificant trend effect race could suggest race played important role depression outcomes following hurricane katrina future studies examine associations prospectively using stronger assessments depression incorporate measures discrimination segregation understand possible racial disparities depression hurricane katrina
review considers australia progress towards elimination hiv aids specified international targets particular considers reaction recent media reports australia ended aids evaluates progress towards reducing hiv transmission recent surveillance data research show significant improvements hiv testing treatment countervailing trends increased condomless sex gay men sex men pre exposure prophylaxis prep implemented scale jurisdictions hope significantly alter trajectory australia hiv epidemic stable last five years around infections per year ongoing challenge maintaining investment also considering respond diversification local epidemic means australia entered critical period evidence prep impact eagerly awaited
tan promising photocatalyst solar water splitting wide spectrum solar energy utilization suitable energy band position straddling water splitting redox reactions however development long impeded poor compatibility electrolytes herein demonstrate simple sputtering nitridation process fabricate high performance tan film photoanodes owing successful synthesis vital tao delta precursors effective gan coating strategy developed remarkably stabilize tan forming crystalline nitride nitride structure improved nitride electrolyte interface stable high photocurrent density obtained copi gan tan photoanode rhe simulated sunlight generated faraday efficiency unity vapor phase deposition method used fabricate high performance oxy nitrides practical photoelectrochemical applications
quadrotors recently drawing greater research commercial attention point become one popular types unmanned aerial vehicles applications vary entertainment transportation commercial even military applications paper novel quadrotor design proposed design decouples motions allowing rotor tilt two directions quadrotor fixed frame modification improves stability safety quadrotor gives manoeuvrability robustness mathematical model proposed system carried using newton euler technique several flight scenarios also simulated simple pid controller illustrate superiority conventional quadrotor designs
presented paper method determination first order symbolic transfer function sensitivity developed based nullor equivalent presentation linear networks important part method takes use modified coates signal flow graph mcsfg proposal effective way easy obtaining sfg representation nullor network given algorithm computer program honeysen present first order symbolic transfer function sensitivity using software dependence first order transfer function sensitivity respect parameter passive element shown
non technical loss ntl fraud occurs fraudster tampers smart meter meter registers less electricity consumption actual consumed amount therefore utility becomes victim suffers corresponding economic loss literature many detection schemes proposed detect ntl frauds however ntl frauds far complicated existing schemes expect recently discovered new potential type frauds variant ntl frauds called colluded non technical loss cntl frauds smart grid cntl fraud multiple fraudsters exist collaborate commit fraud existing detection schemes detect cntl frauds since methods consider existing collaborating fraudsters therefore distinguish one many fraudsters paper propose cntl fraud detector detect cntl frauds proposed method quickly detect tampered meter based recursive least squares identifying tampered meter proposed scheme detect different fraudsters using mathematical models experiments show method effective detecting cntl frauds elsevier rights reserved
amygdala plays key role many affective behaviors psychiatric disorders differ men women test whether human amygdala volume differs reliably sexes performed systematic review meta analysis avs reported mri studies age matched healthy male female groups using four search strategies identified total studies matched samples extracted effect sizes sex difference data converted hedges values pooled effect sizes calculated using random effects model dataset meta regressed study year average participant age found uncorrected amygdala volume larger males pooled sex difference effect sizes right amygdala kappa left amygdala kappa bilateral amygdala kappa volumes values however difference comparable sex differences intracranial volume icv larger males kappa total brain volume tbv larger males kappa reported subsets studies suggesting sex difference product larger brain size males among studies reporting avs normalized icv tbv sex difference effect sizes small statistically significant right amygdala kappa left amygdala kappa bilateral volume kappa values correspond less larger corrected right larger corrected left males compared females summary selectively enhanced human males often claimed although rule subtle male female group differences accurate refer human amygdala sexually dimorphic
frequency existing jak mpl jak jak exon mutations previously investigated mpns poor survival reported primary myelofibrosis low jak allelic burden however mutational status jak exon mpl reported patients study developed cost effective multiplex high resolution melt assay screens mutations jak gene exons mpl gene exon existing mutations jak detected two jak exon four mpl exon patient specimens known jak allelic burden range existing mutations detected specimens jak allelic burden current guidelines recommend testing jak mutation detected mpns findings however indicate quantification jak allele burden may clinically relevant mpns low allelic burden additional testing jak exon mpl exon mutation pursued
article proposes novel soft magnetic entangled metallic wire material emwm first time describes manufacturing quasi static tests samples produced soft magnetic metal wires mechanical properties three batches emwms different porosity investigated different maximum strains different external magnetic fields result shows properties tangent modulus loss factor tunable magnetic field rapidly reversibly compared magnetic field condition tangent modulus emwm samples magnetic field increase similar times average loss factor averagely raises similar results show application emwm novel magneto sensitive smart material feasible applicable
clusterin also known apoj lipoprotein abundantly expressed within cns regulates fibril formation toxicity facilitates amyloid beta transport across blood brain barrier genome wide association studies shown variations clusterin gene clu influence risk developing sporadic alzheimer disease explore whether clusterin modulates regional deposition measured levels soluble extracted insoluble guanidine hcl extracted clusterin beta beta sandwich elisa brain regions predilection amyloid pathologymid frontal cortex cingulate cortex parahippocampal cortex regions little pathologythalamus white matter clusterin level highest regions plaque pathology approximately mirroring regional distribution significantly higher controls correlated positively beta insoluble beta soluble clusterin level rose significantly severity cerebral amyloid angiopathy regions highest apoe homozygotes areas little amyloid pathology clusterin unaltered correlate level significant positive correlation concentration clusterin regional levels insoluble beta however molar ratio clusterin beta declined insoluble beta level region dependent manner lowest regions predilection plaque pathology physiological conditions clusterin reduces aggregation promotes clearance findings indicate clusterin increases particularly regions abundant beta increase match rising level beta molar ratio clusterin beta regions falls probably contributing deposition within tissue
dramatic changes energy landscape provide lens understand local perceptions temporality modernity belonging austerity greece launched european union supported solar energy initiative encourages installation futuristic high tech photovoltaic panels fertile agricultural land however winter witnessed return masse open fires wood burning stoves means people heat homes something locals associate material poverty pre modernity pre europeanization drawing ethnographic research town trikala central greece article demonstrates energy talk provides prism locals discuss past future increasing poverty reassess belonging modern europe
design utilization electronic process guides epgs studied software engineering swe since however empirical findings surveys case studies experiments beneficial effects utilization still lacking thus suggest research utilization epgs required study interested gaining insights effects using epgs objective metrics learning score time effort subjective metrics perceived usefulness ease use value comparing three epg designs simple pdf based epg normal html based epg sophisticated java based epg different blocks experimental subjects practitioners academicians novices experts end conducted controlled experiment sample international participants domain service management found utilization epgs improves objective metrics improvements perceived subjective ones sophisticated epg design appropriate academic expert types users practitioner novice types thus main recommendation design utilization epgs consider type end user elsevier ltd rights reserved
present final results study comparing teriparatide every day risedronate per week started within weeks surgery pertrochanteric hip fracture patients bmd score ohd randomized receive week double dummy treatment plus calcium vitamin followed week open label treatment assigned active drug primary endpoint change baseline lumbar spine bmd weeks secondary exploratory endpoints change bmd proximal femur function hip pain charnley score visual analog scale vas quality life short form radiology outcomes safety data analyzed mixed models repeated measures mmrm logistic regression totally patients randomized teriparatide contributed efficacy analyses mean age years females mean baseline femoral neck total hip scores respectively weeks bmd increased significantly teriparatide compared risedronate versus versus significant group difference bmd timed tug test significantly faster teriparatide weeks differences overall difference hip pain tug test vas significantly lower teriparatide weeks adjusted difference weeks respectively overall difference secondary exploratory outcomes different teriparatide group showed two new hip fractures versus seven risedronate frequent hypercalcemia hyperuricemia conclusion week treatment teriparatide showed significantly greater increases bmd less pain faster tug test versus risedronate american society bone mineral research
climate change unprecedented global threat fundamental life supporting systems people livelihoods expected aggravate development challenges subsistence oriented smallholder farmers developing regions sub saharan africa highly vulnerable changes given lower adaptive capacity context building climate resilient agricultural society essential requirement protect livelihoods hence need spreading climate resilient sustainable agricultural crsa practices replicating proven ones larger areas scaling fostering widespread adoption practices needs consideration social ecological economic institutional appropriateness target areas article reports application tool scala generates information multitude aspects assesses local suitability crsa practices among sub saharan smallholders also briefly presents state art tools used similar purposes first case study tool used assess appropriateness agroforestry biochar application rainwater harvesting fulwe village morogoro tanzania enhancing resilience capacity another case study potential fertilizer management assessed two different villages fulwe mlali analytically appropriateness interventions assessed deviation actual factor constellation scaling process optimal constellation foster wider adoption given practice
introduction thyroid dysfunction common pregnancy adverse fetal maternal health consequences number challenges management gestational thyroid dysfunction remain unresolved including uncertainties optimal thresholds correction hypothyroidism strategies pharmacological management hyperthyroidism areas covered addressed key challenges areas uncertainty management thyroid dysfunction pregnancy expert commentary gestational thyroid hormone reference intervals vary according population ethnicity iodine nutrition assay method population derive trimester specific reference intervals use pregnancy subclinical hypothyroidism isolated hypothyroxinaemia common pregnancy consensus benefits correcting conditions although observational studies show potential benefits levothyroxine child neurocognitive function benefits supported two controlled trials carbimazole avoided first trimester pregnancy due risk congenital anomalies recent studies would suggest risk present lesser magnitude propylthiouracil current international guidelines recommend use propylthiouracil first trimester switching carbimazole remainder pregnancy benefits practicalities approach unproven
starting beta acetoxy homo oxa androst one reaction bromoacetamide nba perchloric acid alpha bromo beta hydroxy beta beta epoxy alpha beta dibromo derivatives obtained structure compounds particularly stereochemistry established detailed nmr ray analysis vitro antiproliferative activity newly synthesized compounds six human tumor cell lines evaluated three compounds showed significant toxicity toward hormone independent breast adenocarcinoma mda cervical carcinoma cells hela dibromo derivative active toward five human cancer cell lines new disubstituted homolactone steroidal compounds also displayed selectivity toward cancerous cell lines inactivity found noncancerous control cell line selectivity found control compound well known chemotherapy drug cisplatin
background although quality life qol experienced patients schizophrenia recognized studies assessed relationship caregivers qol patients qol methods study included stabilized outpatients schizophrenia caregivers mental health services bolivia chile peru caregivers patients qol respectively assessed using two specific qol questionnaires cgqol qol collected socio demographic information clinical data multiple linear regressions performed determine variables associated patient qol tested following hypothesis using structural equation modeling sem caregivers qol may indirect effect patients qol mediated influence severity psychotic symptoms results multivariate analysis caregivers qol significantly associated patients qol except one qol dimension relationship family beta among patients characteristics woman aymara lower educational level unemployment severity symptoms significantly associated lower qol sem revealed moderate significant association caregivers qol psychotic symptoms severity path coefficient significant association psychotic symptoms severity patients qol path coefficient indirect effect caregivers qol patients qol significant mediated effect coefficient conclusion improvement caregiver qol may direct impact psychotic symptoms patients indirectly patient qol confirming need ongoing family interventions regions
paper demonstrates procedural modeling computer graphics techniques combined creating fast accurate realistic modeling archaeological parts buildings used games virtual environments case study ionic order greek roman temples examined particular temple portunus rome italy used case study set geometric algorithms computing shape points based curved surfaces presented allows creating majority ionic temples evaluation results performed based hausdorff frechet distances results indicate proposed method provides good approximation generating accurate ionic order temples however ornaments usually decorate column capital taken account paper
positivity time varying continuous time linear systems electrical circuits addressed necessary sufficient conditions positivity systems electrical circuits established shown exists large class positive electrical circuits time varying parameters examples positive electrical circuits presented
paper presents laboratory evaluation purely frictionally connected geotextile concrete facing block mechanically stabilized earth wall msew systems study focuses investigating governing failure mechanism along wall face determined pullout reinforcement facing blocks herein referred pullout mechanism sliding blocks geotextile reinforcement stays stationery herein referred direct shear mechanism total seventy two tests performed investigate effect laboratory specimen size difference geotextile reinforcement repeatability test results overall results showed lower normal loads sliding blocks geotextile reinforcement along wall face likely occur pullout geotextile blocks higher normal loads order reversed pullout geotextile appears occur first test results also indicated size specimen tested laboratory frictional connection evaluation effect measured connection strength published elsevier ltd
cognitive behavioural functional assessment crucial longitudinal studies neurodegenerative dementias ndd central issues definition study population asymptomatic risk individuals dementia detection change decline assessment relevant outcomes depend quantitative measures cognitive behavioural functional status currently far available reliable protocols tools assessment dementias europe main problems heterogeneity tools used across different european countries lack standardisation administration scoring methods across centres limited information available psychometric properties many tests currently widespread use situation makes hard compare results across studies carried different centres thus hampering research progress particular towards contribution big data common data set present results project funded joint program neurodegenerative diseases jpnd italian ministry health project aimed providing consensus framework harmonisation assessment tools applied research neurodegenerative disorders affecting cognition across europe panel european experts reviewed current methods neuropsychological assessment identified pending issues made recommendations harmonisation neuropsychological assessment neurodegenerative dementias europe consensus achieved general recommendations followed developing procedures tools neuropsychological assessment aim harmonising tools procedures achieve reliable data cognitive behavioural examination results study considered first step enhancing common view practise ndd assessment across european countries
dynamic interplay known exist auditory processing human cognition example prior investigations speech noise revealed learning listening even words within spoken list correctly heard noise later memory words typically impoverished investigations supported view gap intelligibility speech memory speech notion gap speech intelligibility memorability function extent spoken message seizes limited immediate memory resources kiellberg accordingly difficult processing spoken message less resources available elaboration storage recall spoken material however previously known increasing difficulty affected memory processing semantically rich spoken material investigation showed noise impairs higher levels cognitive analysis variant deese roediger mcdermott procedure encourages semantic elaborative processes deployed trial participants listened item list comprising words blocked different themes words bed tired snore associated critical lure theme word presented sleep word lists either presented without noise signal noise ratio decibels upon weighting noise reduced false recall critical words decreased semantic clustering recall theoretical practical implications discussed
growing evidence revealed high fat diet hfd could lead disorders glycolipid metabolism insulin resistant states hfds associated inhibition testicular steroidogenesis previous study demonstrated tetrabromodiphenyl ether bde could increase risk diabetes humans reduce testosterone production rats however whether hfd affects bde inhibited testosterone production elevating insulin levels inducing related pathways remains unknown male rats treated bde gavage weeks hfd significantly increased bde content liver testis increased weight adipose tissue increased macrovesicular steatosis liver levels triglycerides fasting glucose insulin aggravated disruption seminiferous epithelium lowered level testosterone resulting fewer sperm epididymis note hfd enhanced bde induced dax expression decreased expression levels star beta hsd testicular interstitial compartments rats isolated primary leydig cells rats bde insulin increased dax expression decreased expression star beta hsd reduced testosterone production nearly reversed knocking dax results indicated hfd aggravates bde inhibited testosterone production hyperinsulinemia accumulation testicular bde induces regulation dax subsequent regulation steroidogenic proteins star beta hsd leydig cells elsevier inc rights reserved
water soluble amphiphilic anion receptors based urea substituted cyclodextrin synthesized via copper mediated azide alkyne coupling reaction synthetic route designed minimize number operations cyclodextrins stable products obtained yield successfully tested amino acid receptors showing excellent affinity constants highly competitive environment phosphate buffered water solution isothermal titration calorimetry indicated complex formation strongly depends hydrophobic nature guest urea moiety receptor necessary efficiently bind amino acids elsevier ltd rights reserved
light quantity quality modulate grapevine development influence berry metabolic processes studied light information signal developing ripening grape berries vitis vinifera sauvignon blanc field experiment used identify impacts uvb core metabolic processes berries high light low light microclimates primary objective therefore identify uvb specific responses berry processes metabolites distinguish responses elicited variations light incidence canopy manipulation bunch zone via early leaf removal combined uvb excluding acrylic sheets installed bunch zones resulted four bunch microclimates control control uvb attenuation uvb attenuation metabolite profiles three berry developmental stages showed predictable changes known responsive compound classes typical acclimation versus damage response interestingly berries employed carotenoids associated xanthophyll cycles acclimate exposure berry responses differed conditions particularly developmental stages berries still photosynthetically active developmental stage berries important factor consider interpreting data green berries responded different exposure uvb attenuation signals metabolites indicate berries actively managed metabolism relation exposure levels displaying metabolic plasticity photosynthesis related metabolites core processes photosynthesis photo inhibition acclimation maintained differentially modulating metabolites four treatments ripe berries also responded metabolically light quality quantity mostly formed compounds volatiles polyphenols direct antioxidant sunscreening abilities data presented green berries ripe berries conform known uvb light stress young active leaves older senescing tissues respectively provide scope evaluation sink source status fruits relation photosignalling stress management
scholars argued opposition welfare part driven stereotypes african americans argument assumes individuals think welfare spontaneously think black recipients investigated people mental representations welfare recipients studies used perceptual task visually estimate participants mental representations welfare recipients compared average non welfare recipient image average welfare recipient image perceived separate sample african american representative stereotypes associated welfare recipients african americans study participants asked determine whether supported giving welfare benefits people pictured average welfare recipient non welfare recipient images generated study participants less supportive giving welfare benefits person shown welfare recipient image person shown non welfare recipient image results suggest mental images welfare recipients may bias attitudes toward welfare policies
objective two disease modifying therapies licensed use rapidly evolving severe res relapsing remitting multiple sclerosis rrms fingolimod natalizumab discrete event simulation des model analyze cost effectiveness natalizumab fingolimod res population perspective national health service nhs reported methods des model developed track individual res patients based expanded disability status scale scores individual patient characteristics taken res sub groups pivotal trials fingolimod utility data line previous models published costs inflated nhs cost year owing confidential patient access scheme pas discount applied fingolimod range discount levels applied fingolimod list price capture likelihood natalizumab cost effective real world setting results lower national institute health care excellence nice threshold quality adjusted life year qaly fingolimod required discount greater list price cost effective upper threshold pound qaly employed nice fingolimod cost effective confidential discount greater sensitivity analyses conducted using fingolimod list price showed model sensitive changes cost drug particularly fingolimod conclusions des model shows modest discount fingolimod list price required make fingolimod cost effective option natalizumab res rrms
paper describes problem unauthorized access data processed distributed grid computing networks existing implementations entity authentication mechanisms grid systems analyzed disadvantages considered approach use group signature schemes prevents unauthorized access computing environment provides integrity transferred data proposed
background due ability limitlessly proliferate specialize almost cell type human induced pluripotent stem cells ipscs offer unprecedented opportunity generate human brain microvascular endothelial cells bmecs compose blood brain barrier bbb research purposes unfortunately time expense expertise required differentiate ipscs purified bmecs precludes widespread use report use defined medium accelerates differentiation ipscs bmecs achieving comparable performance bmecs produced established methods methods induced pluripotent stem cells seeded defined densities differentiated bmecs using defined medium termed resultant purified bmec phenotypes assessed trans endothelial electrical resistance teer fluorescein permeability glycoprotein mrp family efflux transporter activity expression endothelial markers signature tight junction proteins confirmed using immunocytochemistry influence culture astrocytes pericytes purified bmecs assessed via teer measurements robustness differentiation method confirmed across independent ipsc lines results use medium coupled updated culture methods reduced differentiation time ipscs bmecs thirteen days derived bmecs expressed glut claudin occludin pecam cadherin consistently achieved teer values exceeding omega across multiple ipsc lines maximum teer value omega fluorescein permeability derived bmecs maintained teer omega minimum days showed statistical difference efflux transporter activity compared bmecs differentiated conventional means method also found support long term stability bmecs harboring biallelic park mutations associated parkinson disease finally bmecs differentiated using medium responded inductive cues astrocytes pericytes achieved maximum teer value knowledge highest reported vitro teer value date conclusions given accelerated differentiation equivalent performance reduced cost produce bmecs updated methods make ipsc derived vitro bbb models accessible wide variety applications
energy efficiency aspects cost saving features various radiant cooling systems reported many previous studies however available literature analysis initial investment maintenance costs scanty especially slab integrated one field survey carried green building malaysia installed combined radiant convective system performance multi floor radiant slab cooling system studied energy conservation potential evaluated comparing data obtained building energy management system bems estimated energy consumption conventional convective air system also price quotations service maintenance contracts obtained complete cost benefit evaluation systems found radiant slab cooling system able reduce energy consumption compared conventional variable air volume system providing level air conditioning despite higher initial cost payback period investment cost years findings particularly useful design engineers tropics consider alternative cooling technology large office buildings energy efficient cost effective elsevier rights reserved
supervised injection facilities sifs shown reduce infection prevent overdose deaths increase treatment uptake united states midst opioid epidemic yet sanctioned sif currently operates united states estimate economic costs benefits establishing potential sif san francisco using mathematical models combine local public health data previous research effects existing sifs consider potential savings five outcomes averted hiv hepatitis virus hcv infections reduced skin soft tissue infection ssti averted overdose deaths increased medication assisted treatment mat uptake find dollar spent sif would generate savings total annual net savings million single booth sif analysis suggests sif san francisco would cost effective intervention also significant boost public health system
klinefelter syndrome associated thyroid abnormalities genesis yet fully clear aim study evaluate thyroid function klinefelter syndrome subjects pubertal period chemiluminescent microparticle immunoassay used analyze thyroid stimulating hormone concentration serum samples klinefelter syndrome pubertal boys classic xxy karyotype healthy age matched controls klinefelter syndrome patients also underwent thyrotropin releasing hormone testing evaluate hypothalamic pituitary function levels significantly lower klinefelter syndrome patients age matched controls significant differences found thyroid stimulating hormone serum levels klinefelter syndrome patients tended cluster around lower part reference range assay three thirteen klinefelter syndrome patients undergoing thyrotropin releasing hormone test adequate response one prolonged response min nine responded inadequately study demonstrated first time pubertal klinefelter syndrome patients significantly lower serum levels healthy age matched boys whereas thyroid stimulating hormone normal albeit lower end reference range patients showed inadequate prolonged response pituitary stimulation thyrotropin releasing hormone findings suggest combined form central peripheral hypothyroidism klinefelter syndrome boys pubertal development
background total shoulder arthroplasty end stage glenohumeral arthritis severe glenoid bone loss poses unique challenge shoulder surgeons current surgical solutions limited associated high complication rates hypothesized custom made computer aided design computeraided manufacturing cad cam total shoulder replacement tsr stanmore implants worldwide elstree resembling total hip prosthesis could offer reliable alternative challenging subset patients methods thirty seven patients rotator cuff deficient end stage glenohumeral arthritis severe glenoid bone loss assessed amenable treatment standard anatomic reverse total shoulder implants treated cad cam tsr clinical data collected prospectively analyzed mean follow years results postoperatively pain level activity decreased oxford shoulder score improved points points subjective shoulder value scale improved active forward elevation improved degrees degrees degrees degrees external rotation improved degrees degrees degrees degrees component revision required patients glenoid loosening humeral stem loosening periprosthetic fracture prosthesis dislocation conclusion cad cam tsr offers reliable alternative treatment end stage glenohumeral arthritis severe glenoid deficiency amenable standard anatomic reverse total shoulder implants maintenance significant pain relief clinical functional improvement year postoperative follow journal shoulder elbow surgery board trustees rights reserved
approval use ustekinumab treatment moderate severe psoriasis patients psoriatic arthritis treated drug daily clinical practice aims study describe baseline characteristics evolution cohort patients psoriasis psoriatic arthritis treated ustekinumab compare differences patients discontinued treatment maintained retrospective multicenter observational study including patients received ustekinumab minimum months performed baseline characteristics cohort patients main indication treatment number percentage patients maintained discontinued treatment reasons discontinuation differences patients discontinued maintained ustekinumab evaluated fifty eight patients included main indication dermatological cases treatment ustekinumab maintained patients cases low discontinuation side effects rheumatological lack efficacy discontinuation ustekinumab correlated number obese patients less presence plaque psoriasis number previous biological therapies ustekinumab demonstrated efficacy safety management patients psoriasis psoriatic arthritis daily clinical practice cohort patients
fast analytical technique based matrix approach formulated solve problem direct electromagnetic scattering infinite circular cylinder buried dielectric half space illuminated normally incident transverse magnetic plane wave technique employs signal flow graph sfg model include multiple reflections take place scattering process selection truncation order obtained matrix also discussed
laboratory automation robotics industrialized execution completion large scale enabling high capacity high throughput day screening hts campaigns large libraries compounds complete days weeks critical success hts campaigns ability competent assay development team convert validated research grade laboratory benchtop assay suitable manual semi automated operations hundreds compounds robust miniaturized well format well engineered scalable industrialized assay seamlessly implemented fully automated fully integrated robotic screening platform cost effective screening hundreds thousands compounds provide review theoretical guiding principles practical considerations necessary reduce often complex research biology lean manufacturing engineering endeavor comprising adaption automation implementation hts furthermore provide detailed example specifically cell free vitro biochemical enzymatic phosphatase assay tissue nonspecific alkaline phosphatase illustrates principles considerations
reduced insulin like growth factor insulin signaling iis linked extended longevity species ranging yeast mammals mammals exemplified ames dwarf prop mice increase longevity males females respectively due recessive prop loss function mutation results lack growth hormone thyroid stimulating hormone prolactin laboratory previously shown ames dwarf mice functionally unique white adipose tissue wat improves rather impairs insulin sensitivity thyroid hormone integral adipose tissue development function hypothesized brown adipose tissue bat ames dwarf mice may also functionally unique enhanced elaborate recent findings demonstrate bat functionally enhanced ames dwarf mice suggest bat removal mice results utilization wat depots energy source also discuss findings compare long lived dwarf mice altered iis unlike ames dwarf mice essentially euthyroid lastly provide insights implications findings discuss necessary future work area
rapid gravity filters final particulate barrier many water treatment systems typically monitored using line turbidity flow head loss instrumentation current metrics assessing filtration performance line turbidity data critically assessed observed effectively consistently summarise important properties turbidity distribution associated water quality risk absence consistent risk function turbidity treated water using line turbidity indicative rather quantitative variable appears practical best practice suggests filtered water turbidity maintained ntu higher turbidity less confident effective particle pathogen barrier based simple distinction filtration performance described terms reliability resilience characterising likelihood frequency duration turbidity spikes greater ntu view filtration performance used frame operational diagnosis unsatisfactory performance terms machine learning classification problem calculation operationally relevant predictor variables application classification regression tree cart algorithm conditions associated greatest risk poor filtration performance effectively modelled communicated operational terms provides method evidence based decision support used efficiently manage individual pathogen barriers multi barrier system author published elsevier open access article license
pope pius address discourse sexual morals traditionally limited priests whole humanity questions find answers history encyclical casti connubii based unpublished documents historical archive pontifical gregorian university essay traces parts history tells origin tries interpret meaning document first part paper summarizes main features historical context encyclical alliance catholic church fascism conjugal morals debate demographic campaign politicization sexuality reproduction modernization family feminist claims american birth control movement second part sketches redactional history identity ghostwriter instructions pope
relationship electric current fluctuation efficiency alkaline water electrolysis awe analyzed results presented paper square triangle sine sawtooth current waveforms various frequency amplitude settings applied lab scale electrolyser current densities novel fully automatic measurement data acquisition system designed order generate thousands experiments short period time results show non steady current applied cell cause efficiency loss compared steady condition current density furthermore efficiency loss influenced parameters fluctuating electric current ripple factor frequency mean current density detailed results give new insight investigation water electrolysis efficiency hydrogen energy publications llc published elsevier ltd rights reserved
use electromyographic biofeedback emg injury rehabilitation amply referenced psychological literature despite pioneering work early eighties sports hardly transcended usage sports injury rehabilitation study twelve cases professional players spanish league grouped two different types pathologies fractures upper limbs knee injuries treated emg parallel established rehabilitation plan presented club medical team aba design used session recorded online pre post determine emg gain reached point session procedure considered completed player stably reaches criteria established hemilateral member cases one session tracking outtaken cases include notoriously stable improvements overall results support conclusion emg effective pathologies
paper interesting design precise quadrature oscillator employing electronically controllable current conveyors second generation eccii presented main purpose paper show advantages features direct electronic control application adjustable current gain help signal flow graph approach used clearer visual understanding design discussed circuit presented modification several favorable features grounded capacitors independent electronic adjusting oscillation frequency condition oscillation current gain easy automatic gain control circuit agc implementation non ideal effects tuning process output amplitudes suppressed oscillator designed frequency band units mhz tested two types inertial agcs theoretical presumptions confirmed laboratory experiments
aim study investigate retinal nerve fiber layer rnfl ganglion cell layer gcl thickness macular changes central subfield thickness cst cube average thickness cat cube volume patients migraine using spectral domain optical coherence tomography oct assess correlation white matter lesions wml prospective case control study rnfl gcl thickness macular changes migraine patients aura migraine without aura age gender matched healthy subjects measured using oct device oct measurements taken time day minimize effects diurnal variation average inferior superior quadrant rnfl thickness significantly thinner patients migraine also significant difference patients without aura mean superior quadrant rnfl thickness significant thinning cst cat patients migraine significant difference gcl measurements groups compared control group significant differences control group regarding average superior inferior quadrant rnlf thickness hand significant differences control group regarding average inferior faces oct measurements evaluated according frequency attacks cst gcl thickness significantly thinner patients four attacks month patients wml measurements significantly thinner migraine patients without wml decreased rnfl cst cat migraine patients might related vascular pathology disease wml correlated measurements except think studies needed evaluate etiopathologic relationship oct measurements wml migraine patients
attention deficit hyperactivity disorder adhd common psychiatric disorder affecting children adults soluble ethylmaleimide sensitive factor attachment receptors snare complex implicated adhd pathophysiology since key component neurotransmitter release events neurodevelopment processes snps complex associated adhd aim analyze effects snare complex variants adhd susceptibility clinical heterogeneity affected adults tested association adhd polymorphisms snare genes stxa syt vamp ins del snap sample comprised adults adhd non affected controls regarding clinical heterogeneity investigated effects associated snps age onset impairment due adhd relevant externalizing behaviors school suspensions expulsions problems law authority comorbidities substance use disorder oppositional defiant disorder conduct disorder antisocial personality disorder replicated previously reported association syt adhd adulthood snp also associated age onset impairment due adhd symptoms range externalizing phenotypes findings involving syt suggest variation neurotransmitter exocytosis mechanisms may represent underlying genetic factor shared spectrum externalizing behaviors disorders including restricted adhd elsevier ecnp rights reserved
aim proof concept study explore whether dna methylation first diagnosis associated response disease modifying antirheumatic drugs dmards patients early rheumatoid arthritis patients methods dna methylation quantified lymphocytes treatment naive patients using humanmethylation beadchips treatment response determined months using european league rheumatism eular response criteria results initial filtering identified cytosine phosphate guanines cpgs differentially methylated responders nonresponders conservative adjustment multiple testing six sites remained statistically significant four showed high sensitivity specificity response treatment moreover methylation two sites combination strongest factor associated response sensitivity specificity auc conclusion dna methylation diagnosis associated disease modifying antirheumatic drug treatment response early
subthalamic nucleus deep brain stimulation stn dbs surgical technique treat motor symptoms patients parkinson disease studies shown stn dbs may cause decline verbal fluency performance aimed verify effects stn dbs performance phonemic verbal fluency brazilian patients sixteen participants evaluated unified parkinson disease rating scale part iii phonemic fluency fas version conditions stimulation identified two different patterns phonemic verbal fluency outcomes results indicate may expected pattern effect bilateral stn dbs phonemic fluency patients may present different outcomes reason well understood
present new connections quantum information field classical cryptography particular provide examples simon algorithm used show insecurity commonly used cryptographic symmetric key primitives specifically examples consist quantum distinguisher round feistel network forgery attack cbc mac forges tag chosen prefix message querying messages length assume adversary quantum oracle access respective classical primitives similar results achieved recently independent work kaplan kllnp findings shed new light post quantum security cryptographic schemes underline classical security proofs cryptographic constructions need revisited light quantum attackers
numerous exploratory proof concept interventional studies used histaminergic non histaminergic human models itch however reliability studies surrogate models conducted study investigated test retest reliability response histamine cowhage spiculae induced itch healthy volunteers cowhage spiculae individually applied tweezers histamine applied skin prick test spt lancet volar forearm intensity itch recorded visual analogue scale self reported area itch assessed min itch provocation reliability evoked itch area curve peak intensity assessed coefficient variation intra class correlation coefficient icc sample size estimation parallel cross designs cowhage icc within histamine icc cvbetween within exhibited moderate excellent intra individual reliability moderate inter individual reliability itch intensity test retest observation period one week spt delivered histamine application cowhage spiculae reproducible human models itch high inter individual low intra individual variability suggests cross designed studies applicable
let collection documents strings alphabet size total length describe data structure uses linear space reports relevant documents contain query pattern string length packed log sigma words time log sigma optimal ram model general case log theta logn involves novel ram optimal suffix tree search construction supports ample set important relevance measures number times appears document called term frequency fixed document importance minimal distance two occurrences document log logn show reduce space data structure log log sigma log log log bits log sigma log bits case popular term frequency measure relevance price additive term log epsilon sigma query time constant epsilon also consider dynamic scenario documents inserted deleted collection obtain linear space query time log log log sigma log log log whereas insertions deletions require log epsilon sigma time per symbol constant epsilon finally consider extended static scenario extra parameter par defined query must retrieve documents par epsilon range specified query time solve queries using linear space log sigma log epsilon loge time constant epsilon technique translate top problems multidimensional geometric search problems bonus describe improvements problems
paper presents new algorithm controlling magnetic induction waveform specific measurement system magnetic characterization modeling silicon steel sheets experimental results show new control algorithm measurement system able characterize silicon steel sheets sinusoidal nonsinusoidal waveforms wide frequency amplitude range
water borne diseases estimated cause two million deaths four billion cases diarrhea annually water borne pathogenic organisms include bacteria protozoa viruses heavy metal contamination water also potential threat human health study aimed detect contamination potable water protozoal bacterial pathogens well heavy metals gharbiya governorate middle nile delta egypt therefore study conducted water samples different localities gharbiya governorate throughout year water samples collected source plant tap water four seasons parasitological bacteriological toxicological evaluation carried samples parasitological evaluation done detect protozoal contamination conventional diagnostic staining techniques immunofluorescence assay flow cytometry study identified protozoal contaminants water showed flow cytometry positive results conventional staining also study identified bacterial fecal contamination source water well heavy metal pollution source water since integration flow cytometry could facilitate detection giardia cysts cryptosporidium oocysts water samples strongly recommend use routine detection pathogenic protozoa finally ongoing evaluation drinking water needed well formulation implementation integrated plan limit contamination pathogens heavy metals production hosting elsevier behalf cairo university
uncontrolled generation bradykinin due insufficient levels protease inhibitors controlling contact phase activation increased activity proteins inadequate degradation inactive peptides increases vascular permeability via receptor bkr results subcutaneous submucosal edema formation hereditary acquired angioedema due inhibitor deficiency inh hae aae diseases characterized serious potentially fatal attacks subcutaneous submucosal edemas upper airways facial structures abdomen extremities due inadequate control generation decreased activity inhibitor hallmark inh hae types due mutation inhibitor gene whereas deficiency inhibitor inh aae result autoimmune phenomena hae normal inhibitor significant percentage patients increased activity factor xiia due fxii mutation fxii hae treatment inhibitor dependent angioedema focuses restoring control generation inhibition proteases correcting balance inhibitors breakdown inhibition mediated effects bkr endothelial cells review address pathophysiology clinical picture diagnosis available treatment inhibitor dependent angioedema focusing release regulation key messagesinadequate control bradykinin formation results formation characteristic subcutaneous submucosal edemas skin upper airways facial structures abdomen extremities seen hereditary acquired inhibitor dependent angioedema diagnosis hereditary acquired inhibitor dependent angioedema may troublesome illustrated fact significant delay diagnosis certain grade suspicion therefore crucial quick diagnosis submucosal edema formation hereditary acquired inhibitor dependent angioedema potentially life threatening occur age date effective therapies acute prophylactic treatment available
bone marrow examination aspiration biopsy carried cases pancytopenia megaloblastic anemia commonest cause pancytopenia common conditions presenting pancytopenia micro normoblastic erythroid hyperplasia aplastic anaemia uncommon causes pancytopenia acute leukemia myelodysplastic syndrome mds myelofibrosis multiple myeloma
support cloud computing techniques social coding platforms changed style software development github popular social coding platform project hosting service software developers various levels keep entering github use github save public private software projects large amounts software developers software repositories github posing new challenges world software engineering paper tries tackle one important problems analyzing importance influence github repositories proposed hits based influence analysis graphs represent star relationship github users repositories weighted version hits applied overall star graph generates different set top influential repositories results standard version hits algorithm also conduct influential analysis per month star graph study monthly influence ranking top repositories
objective establishing diagnosis borderline personality disorder bpd adolescents often met controversy part due potential stigmatizing effects wished explore adolescent patient experience diagnosed bpd method impact diagnosis scale iods self report measure developed questions targeting patients subjective experience receiving diagnosis bpd iods administered adolescents approximately one month diagnosis bpd disclosed results twenty one participants analyzable data internal consistency measure demonstrated cronbach alpha found wide variability responses patients tended view diagnosis accurate representation symptoms conclusion iods represents novel means clinicians might better appreciate disclosing diagnosis bpd may impact patient understanding one difficulties
paper aims providing fast near optimum solution multimode resource constrained project scheduling problem mrcpsp large scale projects without resource leveling constraints mrcpsp problem known nondeterministic polynomial time hard hard solved using various exact heuristic metaheuristic procedures paper constraint programming used advanced mathematical optimization technique suits scheduling problems ibm ilog modeling software cplex solver engine used develop optimization model mrcpsp problem unlike many metaheuristic methods literature model fast provides near optimum solution mrcpsp projects hundreds activities within minutes paper compares results two case studies literature prove practicality usefulness approach researchers practitioners one case study used basis creating larger projects activities results reported paper used benchmark researchers compare improve research contributes developing practical decision support system resolving real life constraints projects american society civil engineers
teaching construction planning management challenging construction projects dynamic due many varying unforeseen factors growing number construction related simulations games demonstrate benefits providing students realistic interactive learning experience knowledge applicable real world situations currently majority construction simulation games focus teaching managerial skills either organizational level specific project based activities encourage broader adoption simulation games construction planning management education research effort outlines framework development virtual construction simulator vcs game open source customizable expandable simulation different learning scenarios vcs prototype uses small pavilion case study teach students decisions involved planning subsequently managing project construction affected varying factors weather labor productivity current prototype evaluated usability effectiveness learning tool students undergraduate graduate level courses demonstrating benefits engaging students learning challenges risks efficient construction planning management paper outlines vcs development framework system architecture functionality based defined learning objectives evaluation results future development steps also discussed
paper discusses possibilities using non relational databases data warehouses data mart area traditionally covered relational databases authors highlight potential benefits using non relational databases nosql technology based main characteristics classical relational data base management system rdbms based paper outlines creation production process using nosql data mart develops requirements technology necessary processes based practical experience implementing nosql data marts mongodb clusterpoint since currently exist shelf reporting solutions nosql data storages authors develop requirements reporting solution necessary nosql based
paper proposes novel unsupervised damage detection approach based memetic algorithm establishes normal undamaged condition structural system data clusters global expectation maximization technique using damage sensitive features extracted output vibration measurements health state discriminated considering mahalanobis squared distance learned clusters new observation proposed approach compared state art ones taking account real world data sets bridge switzerland several damage scenarios performed results indicated proposed approach applied structural health monitoring applications life safety economic reliability issues important motivations consider
osteoporosis major comorbidity cardio respiratory diseases mechanistic links pulmonary arterial hypertension bone remain elusive purpose stud evaluate serum adipokines endothelin levels patients idiopathic pulmonary arterial hypertension ipah nyha class iii determine associations bone mineral density bmd pulmonary hemodynamic parameters bmd scores lumbar spine femoral neck serum leptin adiponectin visfatin endothelin evaluated patients ipah nyha class iii healthy volunteers leptin adiponectin higher patients ipah healthy subjects visfatin level showed tendency increase compared healthy subjects univariate analysis revealed positive correlation bmd scores sites min walk test inverse relation pulmonary vascular resistance pvr mean pulmonary arterial pressure mpap adiponectin visfatin showed positive correlations pvr serum adiponectin visfatin leptin inversely associated scores adjusting bmi fmi associations persisted visfatin adiponectin levels scores sites related mpap cardiac index pvr negative correlation observed bmd positive correlations revealed adiponectin visfatin ipah patients results provide evidence adipokine endothelial dysregulation may cause decrease bmd also increase hemodynamic disorders ipah
era cloud computing big data virtualization gaining great popularity storage systems since multiple guest virtual machines domus running single physical device disk fairness among domus aggregated throughput remain challenges virtualized environments although several methods developed disk performance virtualization among multiple domus suffer one following drawbacks fair scheduling mechanism missing requests converge together multiple queues existing methods rely better performance underlying storage system solid state drive ssd throughput latency considered simultaneously address disadvantages paper presents virtual multi channel disk vmcd method built top ordinary storage utility mitigates interference among multiple domus using separated virtual channel channel request queue domu vmcd several mechanisms employed enhance performance including credit allocation mechanism global monitoring strategy virtual multi channel fair scheduling algorithm proposed techniques implemented xen virtual disk evaluated linux guest operating systems experiments results show vmcd increases fairness percent approximately compared cfq anticipatory schedulers percent approximately compared deadline scheduler enhances bandwidth utilization percent approximately compared cfq anticipatory schedulers percent compared deadline case three virtual domus running physical host
background many people living hiv suffer depressive symptoms previous pilot study self help cognitive behavioral therapy booklet format found effective treating depressive symptoms people hiv developed online self help program dutch english based booklet people hiv depressive symptoms besides main question regarding effectiveness program aimed lowering depressive symptoms sub questions focus moderators treatment success patients program especially beneficial mechanisms change underlying treatment outcome mediators affect outcome treatment paper protocol study described methods design effectiveness program investigated comparing intervention group waiting list control group randomized controlled design including pretest three post tests self help program contains four main components activation relaxation changing maladaptive cognitions goal attainment participants mild moderate depressive symptoms work program weeks coach provide motivational support telephone week participants control condition receive weekly minimal support coach weeks second post test gain access self help program depressive symptoms possible mediators activation cognitive coping self efficacy goal adjustment assessed self report three times intervention waiting period pretest first post test discussion proposed study aims evaluate effectiveness online self help intervention people hiv depressive symptoms intervention shown effective program implemented consequently many patients hiv could reached psychological care may improved
potential impact violent media children emotional well source controversy several decades date evidence negative impact violent media emotional well mixed increasingly connected replication crisis throughout psychological science current study examines concurrent prospective relationships violent media use symptoms depression anxiety sample mostly hispanic youth males age range youth parents surveyed regarding social environment media use mental health youth responded year follow results indicated neither violent television use violent video game use predicted anxiety depression concurrently depression prospectively sample impact media violence use child mood symptoms appears minimal research may wish focus particular risk groups
young children surrounded fictional media including books videos games often expected learn new information explicitly fictional sources simultaneously avoiding confusion true real world versus true fictional worlds children navigate reader dilemma current review addresses question first examining whether fiction change children real world knowledge behaviors generally learning specific pieces information fictional contexts bulk research suggests children learn new information fiction ask whether fiction teaches children effectively types activities nonfiction media well whether differences children learning realistic opposed fantastical fiction many open questions topics remain including selective children learning fiction properties media affect selectivity long children retain information learned fictional contexts child level factors like age may affect learning close review addressing issues offering suggestions future research area elsevier inc rights reserved
water pollution major environmental human health issue sarno river regarded polluted river whole europe study aimed evaluating antioxidant response freshwater pollution sarno river campania south italy using bags containing biosensor water plant lemna minor homogeneous samples minor collected botanical gardens university naples accurately washed disposed nylon bags bags exposed one week floating water sarno river three sites determine antioxidant response pollutants five heavy metal concentrations representative pollution river measured three exposure sites ultrastructural alterations exposed samples examined confirm environmental stress underwent exposes samples three different methods used measure antioxidant activity trolox equivalent antioxidant capacity chemiluminescence gst activity assays moreover specimens vitro exposed heavy metal concentrations measured three exposure sites river results compared obtained bag experiment minor reacted pollution increasing antioxidant activity gets higher river springs towards flatland see bag experiments related heavy metal concentrations see vitro experiments furthermore tem observations showed cell ultrastructure alterations increased along river way antioxidant activity results confirmed potential use species biosensor methodological approach biomonitoring phytoremediation studies
study used paper pencil questionnaire investigate whether teachers administrators parents differed preferences accuracy interpreting visual data displays decision making data analysis used nonparametric tests due violations distributional assumptions using parametric tests found significant differences three groups graph preference within two groups found statistically significant differences preference also found statistically significant differences accuracy parents administrators two graphs grouped columns stacked columns implications researchers education stakeholders recommendations research provided
research aim impairment nonverbal communication persons autism spectrum disorders asd specific dominant symptom disorder clinical picture becomes diagnostic criterion well differential diagnostic criterion predicts development time striking determinant socialization persons given impairment range impairments form communication variable manifested differently individual asd paper primarily focus area non verbal communication associated deficits related reception expression facial expressions theoretical basis initial part given paper subsequently supplemented research investigation carried institute special education studies faculty education palacky university olomouc communication deficits selected forms impaired communication ability focus assessment sub determinants verbal nonverbal element communication special education practice faculty education pdf objectives given research investigation differentiated two parts focused reflection impaired nonverbal communication persons asd perspective speech language therapists working health care education facilities analysis impaired nonverbal communication selected group pre school aged children asd methodology first research method questionnaire distributed speech language therapists working health care facilities set ministry education youth sports another research method longitudinal observation within time period march june order assess nonverbal communication persons autism spectrum disorders diagnosis impaired communication ability applied specifically part diagnosis nonverbal communication created rihova vitaskova results conclusions clear results research investigation impairment nonverbal communication persons asd evident symptom difference extent impairment individual forms nonverbal communication specific reflect individual abilities dispositions child well especially specific type asd diagnosis look specific results acquired questionnaires distributed speech language therapists czech republic evident persons asd addressed specialists frequently record deficits pertaining visual contact facial expressions perceive negative fact speech language therapists prefer development nonverbal communication part speech language intervention persons asd presented results could incentive reflect significance deeper diagnosis impaired nonverbal communication persons asd form important diagnostic tool also significant intra phenomenon differentially diagnostic marker
paper two new voltage mode universal biquadratic filters one input terminal five output terminals presented proposed circuits realize voltage mode highpass bandpass lowpass notch allpass filter transfer functions simultaneously using two plus type differential difference current conveyors ddccs two grounded capacitors three resistors moreover proposed circuits following attractive advantages realization standard filter functions circuit configuration employment grounded capacitors ideal integration iii low active passive sensitivities
non orthogonal multiple access noma attracted significant attention research community potential candidate future radio access article presents noma based cooperative network transmitter considered base station communicates simultaneously two users treating far user near user via help half duplex decode forward relay investigate outage probability outage capacity proposed network independent rayleigh slow fading channels closed form expressions outage probabilities derived users approximate outage capacity users also investigated high signal noise ratio regime shown proposed cooperative noma achieve superior performance compared non cooperative noma terms outage probability tightness simulation theoretical results confirms efficiency proposed protocol
research introduces novel magnetically isolated phase structure switched reluctance motor namely septi segment srm sssrm proper high torque volume lowest leakage flux different fields industries sssrm contains seven stator layers isolated magnetically also include assembly stator rotor poles three layers energized time generating higher torque lower ripple compared typical srm furthermore configuration results advantages easy cooling independent phases evaluate proposed motor performance configuration introduced first secondly motor profiles flux linkage flux density self mutual inductance motor torque assessed using finite element method fem sssrm manufactured test bench laboratory experimental results new motor typical type compared volume area results comparative study clearly demonstrate prominent features proposed motor various applications copyright john wiley sons ltd
rainwater harvesting rwh systems increasingly implemented buildings common simple rwh tank sizing methods utilised consider future climate change paper describes development tool integrates elements basic detailed sizing approaches british standard rwh latest probabilistic climate projections data method initially applied design university building cornwall methodology utilises equi probable rainfall patterns tank sizing time period results indicate ensure likely non potable demand could met present tank larger would required increases sizing likely probability meeting level non potable demand rwh system design assessed three locations different rainfall characteristics assessments simplified method developed enable practitioners size rwh system tanks current future climates method provides new approach meet present future non potable demands preventing excessive sizing tanks
balance adipocyte osteoblast differentiation key link disease progression obesity osteoporosis previously reported formononetin fnt isoflavone extracted butea monosperma stimulates osteoblast formation protects postmenopausal bone loss inverse relationship osteoblasts adipocytes prompted analyse effect fnt adipogenesis vivo bone loss triggered high fat diet hfd induced obesity anti obesity effect mechanism action fnt determined cells hfd induced obese male mice findings show fnt suppresses adipogenic differentiation fibroblasts regulation key adipogenic markers ppar gamma ccaat enhancer binding protein alpha ebpa sterol regulatory element binding protein srebp inhibits intracellular tag accumulation increased intracellular reactive oxygen species levels amp activated protein kinase ampk activation accompanied stabilisation beta catenin attributed anti adipogenic action fnt vivo weeks fnt treatment inhibited development obesity mice attenuating hfd induced body weight gain visceral fat accumulation anti obesity effect fnt results increased energy expenditure fnt also protects hfd induced dyslipidaemia rescues deterioration trabecular bone volume increasing bone formation decreasing bone resorbtion caused hfd fnt rescuing action obesity induced osteoporosis commenced level progenitors bone marrow progenitor cells obtained hfd mice group supplemented fnt showed increased osteogenic decreased adipogenic potentials findings suggest fnt inhibits adipogenesis ampk beta catenin signal transduction pathways protects hfd induced obesity bone loss
discrete event simulation des widely used scheduling analysis construction projects integration des fuzzy logic enhances capabilities des capturing imprecise subjective linguistically expressed knowledge simulation inputs using fuzzy numbers however available fuzzy discrete event simulation fdes methodologies significant shortcomings handling fuzzy ranking updating simulation time limitations often result inaccurate estimation start completion times individual activities whole project paper presents new approach calculating event times increase accuracy simulation time estimation fdes major contributions paper integrating des fuzzy logic increase applicability construction domain increasing accuracy fdes results proposed fdes approach implemented construction project scheduling example confirms higher accuracy proposed methodology compared existing fdes methodologies
obesity associated tumor promoting pathways related insulin resistance chronic low grade inflammation linked various disease states including cancer many studies focused relationship obesity increased estrogen production contributes pathogenesis estrogen receptor positive breast cancers link obesity breast cancer subtypes triple negative breast cancer tnbc neu breast cancer less clear hypothesize obesity may associated pathogenesis specific breast cancer subtypes resulting different subtype distribution normal weight women single institution retrospective analysis tumor characteristics patients diagnosed primary operable breast cancer performed evaluate association bmi clinical outcome patients grouped based bmi time diagnosis stratified three subgroups normal weight bmi overweight bmi obese bmi distribution breast cancer subtypes across three bmi subgroups compared obese overweight women likely present tnbc normal weight women breast cancer demonstrated first time breast cancer subtype distribution varied significantly according bmi status results suggested obesity might activate molecular pathways well known obesity estrogen circuit pathogenesis breast cancer future studies needed understand molecular mechanisms drive variation subtype distribution across bmi subgroups
objective cervical imaging practices poorly understood young children traumatic brain injury tbi therefore sought identify child level hospital level factors associated performance cervical imaging children tbi falls abusive head trauma aht describe across hospital variation cervical imaging performance hypothesized imaging decisions would influenced hospital volume young injured children methods performed retrospective study children younger years age tbi premier perspective database adjustment observed patient characteristics evaluated variation advanced cervical imaging computed tomography magnetic resonance imaging children aht tbi falls results children tbi abuse falls fifteen percent children tbi underwent advanced cervical imaging moderate severe head injuries associated increased odds cervical imaging aht odds ratio confidence interval falls odds ratio confidence interval association annual hospital volume injured children cervical imaging performance adjusted probability imaging across hospitals ranged aht tbi falls conclusions results highlight variation across hospitals adjusted probability cervical imaging aht nearly fold tbi falls fold explained observed patient characteristics variation suggests opportunities research inform imaging practices
solid epidemiological evidence indicates part risk obesity adulthood could programmed prenatal development quality maternal nutrition nevertheless molecular mechanisms involved mostly unknown hinders capacity develop effective intervention policies discuss hypothesis mechanisms underlying prenatal programming adult risk epigenetic sensitive environmental cues nutrition information encoded dna essentially stable regulatory epigenetic mechanisms include reversible covalent modifications dna chromatin methylation acetylation etc known dietary availability methyl donors impact patterns gene expression affecting dna methylation regulatory regions likely basis reprogramming developmental plasticity agouti axin psed genes well embryonic growth factor igf locus examples diet induced modulation phenotypic traits affecting methylation gene regulatory regions recent work evidenced unsuspected role chromatin metabolic sensor chromatin susceptible number post translational modifications modulate gene expression among gicnacylation histone proteins epigenetic regulators intracellular levels precursor molecule udp gicnac hence degree global chromatin gicnacylation depend energetic state cell making gicnacylation functional link nutrition regulation gene expression dietary interference regulatory mechanisms could effectively counteract early life programming adult risk elsevier inc rights reserved
past decades water pollution suggested leading factor infectious diseases worldwide concern use photocatalysts degrade organic pollutants waste water however requirement light assistance degradation process limited application photocatalysts paper mos pdms nanocomposite fabricated order overcome problem results showed mos pdms nanocomposite provide high degradation activity purify waste water without light assistance mos pdms nanocomposite preserved activity toward dye rhodamine degradation even fourth cycling test found high degradation activity mos pdms nanocomposite based piezo catalytic effect single layers mos nanoflowers nanocomposite also demonstrated mos pdms nanocomposite useful material fabrication nanogenerator harvest waste water energy direct coating mos pdms nanocomposite metal grid electric outputs generated water flow passing nanogenerator addition coating mos pdms nanocomposite flat electrode placing inside water pipe nanogenerator could act source electric output also self powered sensor locate water passage route contamination areas waste water
paper presents amethodology use structural responses monitor progress construction processes methodology implemented launching girder used viaduct construction metro rail project strain based wireless sensor network used data acquisition structural responses launching girder used identify state construction conventional system identification methodology tested application accurate inferring stage construction therefore modified system identification strategy using derived features heuristics used infer state construction modified methodology found significantly accurate conventional methodology well suited applications unstructured construction environments results case study confirm use structural responses feasible measuring progress construction activities elsevier rights reserved
medication discontinuation major risk factor relapse schizophrenic patients present study investigated rate clinical correlates complete medication discontinuation year hospital discharge data collected schizophrenia patients prescribed anti psychotics documented socio demographic characteristics symptom severity insight attitudes towards medication week discharge experience caregiver burden primary caregiver recorded time hospitalization follow telephones call one year discharge documented whether regularly taking prescribed psychotropic medication logistic regression analysis used investigate factors independently associated medication discontinuation altogether sample discontinued medication one year discharge logistic regression analysis showed shorter duration illness lack health insurance poor insight time discharge significantly associated complete discontinuation medication patients discontinued medication within year psychiatric hospitalization associated lack insurance coverage less insight illness shorter duration illness interventions strengthen patient engagement treatment insurance coverage insight fostered psychoeducational intervention may increase medication compliance
background atrial tachycardias ats including atrial fibrillation common arrhythmias occurring late mitral valve surgery management challenging objective purpose study determine electrophysiological mechanisms ats patients prior surgery long term outcomes catheter ablation methods studied consecutive patients mean age years men prior surgery presented ats postoperatively results clinically documented electrophysiology study patients whereas remaining patients inducible study total ats spontaneous inducible characterized overall right atrium chamber origin underlying mechanism macroreentry cases included typical flutter mitral annular flutter incisional right roof dependent reentry local left atrial reentry eight focal ats also documented left atrium left sided ats common patients prior maze procedure mitral annular flutter twice prevalent group ablation acutely successful freedom atrial arrhythmias months requiring procedure conclusion macroreentry predominant mechanism patients prior surgery circuits often localized left sided ats common patients prior maze procedure repeat procedures common outcomes year complete control good
background spondyloarthritis spa traditionally encompasses ankylosing spondylitis psoriatic arthritis reactive arthritis associated inflammatory bowel diseases sacroiliac joint sij inflammation important usually first finding spa objectives aim retrospective study assess value different magnetic resonance imaging mri sequences evaluation bone marrow subchondral bone changes active sacroiliitis inter intra observer reliability sequences patients methods ninety patients males females meanage years range withmrifindings suggestive active sacroiliitis selected picture archive communication system pacs consensus two radiologists sijs retrospectively analyzed two radiologists separately blinded evaluations sequence evaluated different times one week apart monitor pacs system observer periarticular bone edema contrast enhancement recorded separately observer results highest agreement measurements observer found contrast enhanced fat suppressed weighted imaging among sequences axial planes within sequences taken contrast injections conclusion twand twsequences axial planes useful sequences determination active sacroiliitis therefore patients renal failure allergy contrast media obtained detect active sacroiliitis
explore potential using small unmanned aerial vehicle uav quadcopter collect long dwell imagery nearshore important measurements made low cost flexibility paper extends existing topographic imaging approaches rely plentiful ground control spread across image nearshore case bulk image water control point vehicle metadata must used uav autopilot found capable excellent station keeping positional errors horizontal vertical viewing angle errors degrees tilt roll degrees azimuth ground position imaged objects could found accuracy metadata returned uav camera position accurate camera roll could assumed degrees reducing ground control requirements two even one location even extreme simplification ground position errors averaged worse cases control points near uav used model visual contrast waves viewed different angles found large tilts important contrast theory little dependence viewing azimuthal angle derived argus products agreed well products collected using traditional fixed argus station uavs appear promising alternate fixed camera systems limited duration sampling adequate
purpose implementation lean methodology pharmacy residency programs community teaching hospital described summary new hanover regional medical center community teaching hospital southeastern north carolina fully adopted lean culture given success lean strategies organizationally methodology used assist evaluation development pharmacy residency programs lean tools activities also incorporated residency requirements rotation learning activities majority lean events correspond required competency areas evaluating leadership management teaching education events included participation facilitation various lean problem solving communication tools application rules lean resulted enhanced management programs provides set tools continual quality improvement ensured regular communication direct involvement invested parties critical developing sustaining new improvements addition program enhancements lean methodology offers novel methods residents may incorporated leadership activities conclusion incorporation lean methodology pharmacy residency programs translated variety realized potential benefits programs preceptors residents health system specific areas growth included quality improvement processes expansion leadership opportunities residents improved communication among program directors preceptors residents
dimensional coupled nonlinear schrodinger system investigated describes pulses optical fiber transverse effects nonlinear optical system aid symbolic computation hirota method bright one two soliton solutions system derived basis soliton solutions graphically discuss head collisions include elastic inelastic collisions two bright solitons elastic collision two colliding solitons keep shapes amplitudes velocities unchanged except phase shifts inelastically intensity one soliton enhanced gets suppressed elsevier ltd rights reserved
background aims bone marrow derived progenitor cells functionally impaired patients ischemic heart disease ihd thereby hampering outcome autologous stem cell therapy search underlying mechanisms dysfunction accelerated cellular senescence explored methods analysed telomere length derived mononuclear cells mnc mmqpcr patients coronary artery disease ischemic heart failure non ischemic controls related myeloid differentiation capacity expressions senescence associated genes cip lnka telomere maintenance genes tert trf sirt mnc evaluated using qpcr pro inflammatory cytokine levels tnf alpha ifny measured msd results mnc telomere length shortened patients ihd irrespective associated cardiomyopathy shortened increasing angiographic lesions telomere shortening associated reduced myeloid differentiation capacity mnc suggesting accelerated senescence underlying cause progenitor cell dysfunction ihd lnka cip activated ihd inversely related myeloid differentiation capacity mnc hence mnc functional impairment worsens increasing senescence mnc telomere attrition related alterations tert trf sirt expression ifny levels associated cip lnka upregulation suggesting link inflammation cellular senescence still trigger telomere shortening ihd needs elucidated conclusions accelerated replicative senescence associated functional impairment derived progenitor cells ihd could targeted improve efficacy stem cell therapy elsevier rights reserved
aim review describe hiv prevalence children youth living street subject commercial sexual exploitation studies characteristics terms place time population sample design systematic review meta analysis based article search electronic databases science direct medline ovid lilacs wiley interscience consult springer link embase web science ebsco complementary search also performed libraries schools public health webpages agencies besides reference lists selected articles selected observational studies focused children youth living street subject commercial sexual exploitation ranging age years results hiv prevalence rates total references retrieved met inclusion criteria comprise descriptive summary articles conducted children youth living street three children subject commercial sexual exploitation cross sectional studies hiv prevalence children youth living street ranged dallas usa cochabamba bolivia petersburg russia children youth living subject commercial sexual exploitation prevalence ranged toronto canada kolkata india conclusion hiv infection present children youth living street subject commercial sexual exploitation measures needed prevention diagnosis treatment public health priority ethical responsibility part governments society
development commercialization photovoltaic cells good cost efficiency trade using critical raw materials crms one strategies chosen european community address energy roadmap context cuznsns czts solar cells attracting major interest since potential combine low price relatively high conversion efficiencies although approximate lab scale efficiency already reported czts technology still far competitive terms cost per peak power sic common materials one possible near future solution increase czts competiveness comes thermoelectrics actually already shown hybrid thermoelectric photovoltaic systems htepvs based cigs another kesterite similar czts lead significant efficiency improvement however also clarified optimal hybridization strategy come simple coupling solar cells commercial tegs special layouts implemented furthermore since solar cell performances well known decrease temperature thermal decoupling strategies teg sections taken address issues developed model two different htepv solutions coupled czts solar cells first case considered thermally coupled htepv device htepv teg placed underneath solar cell thermal contact second system consists instead optically coupled thermally decoupled device htepv part solar spectrum focused non imaging optical concentrator teg hot side solutions model returns conversion efficiencies higher czts solar cell alone specifically increases approximate predicted kind systems considered
factor analysis target transformation techniques applied compact reconnaissance imaging spectrometer mars crism spectral dataset identify spectral endmembers reduce noise automate image analysis techniques allow rapid processing images identification weak spectral signals applied automated technique crism images successfully identified endmembers including phyllosilicates serpentine nontronite illite sulfates gypsum carbonates magnesite hydrated silica test techniques factor analysis target transformation applied available full spectral resolution covering nili fossae region data identify occurrence carbonate region also applied factor analysis target transformation noise reduction algorithm also allows improved results common image analysis techniques including spectral ratios index maps elsevier inc rights reserved
ultra wideband uwb technology attracted great interest provide promising solution future radar short range broadband wireless communications generation millimeter wave uwb signals using photonic approaches reduce high cost millimeter wave electrical circuits moreover well compatible fiber transmission effectively extend signal coverage paper novel approach photonic generation millimeter wave uwb signals dual band operation consideration proposed proposed scheme simultaneously generate millimeter wave uwb signals ghz ghz millimeter band efficiently exploit spectrum limit allowed fcc mask using linear combination pulse design concept model describing proposed system developed generation ghz millimeter wave uwb signals demonstrated via computer simulations
work interaction aspirin molecule external surface boron nitride fullerene like nanocage studied means density functional theory dft calculations equilibrium geometry electronic properties adsorption energy thermodynamic stability identified adsorbed configurations four stable configurations obtained interaction molecule nanocage adsorption energies range kcal mol level results clearly indicate doping tends increase adsorption energy thermodynamic stability molecule nanocage study adsorption bnal presence protic water aprotic benzene solvent found calculated binding distances adsorption energies pcm cpcm solvent models similar especially complexes according time dependent dft calculations doping shift estimated lambda max values toward longer wavelengths redshift solvent effects also important influence calculated electronic absorption spectra complexes
study order demonstrate versatility active building block called current differencing transconductance amplifier cdta current mode frequency agile filter faf application circuit designed derived order class faf employs three cdtas two capacitors single resistor layout designed cdta post layout simulations performed using cadence spectre tool tsmc level cmos technology process bsimv parameters simulation results confirm theoretical findings
leptospira spp diderm two membranes bacteria infect mammals causing leptospirosis public health problem global implications thousands people die every year due leptospirosis especially developing countries tropical climates prophylaxis difficult due multiple factors including large number asymptomatic hosts transmit bacteria poor sanitation increasing numbers slum dwellers lack effective vaccine several leptospiral recombinant antigens evaluated replacement inactivated bacterin vaccine however success limited prospective vaccine candidate likely surface related protein stimulate host immune response clear leptospires blood organs study comprehensive bioinformatics approach based reverse structural vaccinology applied toward discovery novel leptospiral vaccine candidates leptospira interrogans serovar copenhageni strain genome mined silico enhanced identification conserved beta barrel beta transmembrane proteins outer membrane lipoproteins orthologs prospective vaccine candidates screened genomes additional leptospira spp three dimensional structural models high degree confidence created surface exposed proteins major histocompatibility complex mhc epitopes identified locations mapped structural models total beta transmembrane proteins lipoproteins identified proteins conserved among pathogenic leptospira spp predicted epitopes several variants mhc receptors structural functional analysis sequence surface proteins demonstrated beta transmembrane proteins seem tonb dependent receptors associated transportation proteins identified included tolc efflux pump proteins bama like component beta transmembrane protein assembly machinery lptd like lps assembly protein structural mapping immunodominant epitopes identified location conserved surface exposed immunogenic regions vaccine candidate proteins identified study currently evaluated experimental evidence involvement virulence disease pathogenesis physiology addition vaccine development
although previous research investigated relationships media consumption sexism rape myth acceptance rma limited research investigated video games despite emergence one popular forms media entertainment globally given video games typically feature even less diverse objectified representations women traditional mainstream media predicted would relationships video game consumption negative beliefs attitudes women study conducted survey male female adults used structural equation modeling analyze relationships among video game consumption trait interpersonal aggression ambivalent sexism first order percentage false rape accusations second order cultivation effects rma found support hypothesized cultivation model indicating relationship video game consumption rma via interpersonal aggression hostile sexism although findings interpreted causally discuss implications associations future directions research
time dependent diffusion equations fractional laplacian received considerable attention recent years numerical methods play important role simple analytic solution often unavailable analyze paper parareal algorithm kind problem realizes parallel time computation algorithm iterative uses order sdirk singly diagonally implicit runge kutta method small step size delta propagator implicit explicit euler method large step size delta propagator two step sizes satisfy delta delta integer using implicit explicit euler method propagator potentially improves parallel efficiency complicates convergence analysis employing technical analysis provide sharp estimate convergence rate independent mesh ratio distribution eigenvalues coefficient matrix extension results problems time periodic conditions also given several numerical experiments carried verify theoretical results elsevier inc rights reserved
although still debated whether vasoconstriction underlies migraine resolution triptans recommended patients cardiovascular risk however relationship stroke incidence triptan use unclear unknown whether acute chronic use drugs worsens ischemic brain injury address issue investigated effect clinically relevant doses potent cerebral artery vasoconstrictor eletriptan cerebral blood flow cbf brain infarct volumes well expression genes involved cerebrovascular regulation report acute treatment rats mice eletriptan reduce basal cbf promptly dropped upon treatment prazosin dihydroergotamine acute chronic month eletriptan also affect cbf changes infarct volumes mice undergoing brain ischemia reperfusion finally chronic eletriptan reduced brain mrnas pacap vip leaving unaffected cgrp significant transcript changes found dura mater data suggest impact triptans cerebral hemodynamic evaluated well propensity increase stroke risk migraineurs ibro published elsevier ltd rights reserved
construction industry nonhomogeneous also managing construction projects difficult today world construction projects huge contractors want accomplish within short time fast changing era therefore time resource managed successful construction project management resource leveling one primary tools used managing resources target leveling resources within minimum time period complete project successfully resource constrained project scheduling problems rcpsp non deterministic polynomial time hard hard problem therefore heuristic methods used solve paper presents harmony search method solving rcpsp order compare performance developed software three examples chosen literature computational results indicate harmony search method effective rapid suitable rcpsp existing solutions
lung cancer one common non aids acquired immune deficiency syndrome defining malignancies occurs frequently persons living human immunodeficiency virus plwhiv hiv negitive population compared hiv negative counterparts patients usually younger diagnosed advanced stages pathogenesis plwhiv fully understood immunosuppression pri combination chronic infection oncogenic effects smoking hiv seem play role currently established preventive screening available making smoking cessation promising preventive measure treatment protocols standards general population notably immuno oncology also become standard care significant subset hiv infected patients drug interactions hematological toxicity must taken account multidisciplinary approach include physician experienced treatment hiv limited data available novel targeted therapies checkpoint inhibitors setting hiv karger gmbh freiburg
background inflammatory bowel disease ibd affects quality patients life many ways aim study develop validate mainland chinese version ibd quality life questionnaire ulcerative colitis crohn disease methods draft questionnaire containing items generated descriptive qualitative study literature review consulting ibd patients experts validity discriminant ability reliability sensitivity change validated patients ibd results item ibd quality life questionnaire ibdqol domains developed domain scores ibdqol correlated well related item short form health survey dimensional scores total scores ibdqol correlated well physical component summary scores mental component summary scores colitis activity index activity index able discriminate patients active inactive disease cronbach alpha domains ibdqol ranged test retest reliability excellent intraclass correlation coefficient domains ibdqol emotional function symptoms discomfort bowel symptoms influences able detect changes patients whose clinical activity index changed one point conclusions ibdqol valid reliable responsive instrument assessing disease specific quality life patients ibd mainland china
purpose study evaluate utility human adipose stem cells derived buccal fat pad hbfp ascs nerve regeneration parkinson disease neurodegenerative disorder characterized progressive death dopaminergic neurons candidate disease cell replacement therapy fundamental therapeutic methods examined properties neural related cells induced hbfp ascs cell source treatment hbfp ascs cultured neurogenic differentiation medium weeks morphology hbfp ascs changed neural like cells medium replaced neural maintenance medium cells differentiated hbfp ascs showed neuron like structures expressed neuron markers beta tubulin neurofilament microtubule associated protein astrocyte marker glial fibrillary acidic protein dopaminergic neuron related marker tyrosine hydroxylase induced neural cells transplanted hydroxydopamine ohda lesioned rat hemi parkinsonian model weeks transplantation ohda lesioned rats subjected apomorphine induced rotation analysis transplanted cells survived brain rats dopaminergic neural cells tumor formation found cell transplantation demonstrated differentiation hbfp ascs neural cells transplantation neural cells improved symptoms model rats results suggest neurons differentiated hbfp ascs would applicable cell replacement therapy
work presents application terahertz imaging three dimensional formalin fixed paraffin embedded human breast cancer tumors results demonstrate capability terahertz depth scanning produce cross section images without need slice tumor samples tumors excised women diagnosed infiltrating ductal carcinoma lobular carcinoma investigated using pulsed terahertz time domain imaging system time flight estimation used obtain vertical horizontal cross section images tumor tissues embedded paraffin block strong agreement shown comparing terahertz images obtained electronically scanning tumor depth comparison histopathology images detection cancer tissue inside block found accurate depths image processing techniques applied provide improved contrast automation obtained terahertz images particular unsharp masking edge detection methods found effective three dimensional block imaging
nowadays marine scientists making use kadomtsev petviashvili category equations investigations straits georgia gibraltar adriatic sea north sea south china sea fluid mechanics fields dimensional type equations attracted good size recent research generalized dimensional variable coefficient type equation nonlinear waves fluid mechanics symbolic computation obtain variable coefficient dependent auto backlund transformation along two variable coefficient dependent families shock wave type solutions elsevier ltd rights reserved
herein studied absorption alkanolamine protic ionic liquids binary mixtures based hydroxyethylammonium mea triethanolammonium cations residues hydroxy sulfobenzoic acid pyridine carboxylic acid various temperatures partial gases pressures found absorbents based hydroxyethylammonium cation performed high absorption properties toward solubility hydrogen sulfide characterized henry law constant mea based binary mixtures values comparable commercially available ionic liquids results thermal desorption analysis demonstrated capture acid gases meabased absorbents occurred two stages dissolution mea component protic ionic liquid
article addresses effects glycerol gly concentrations mechanical properties calcium polyphosphate cpp bone substitute structures manufactured using binder jetting additive manufacturing achieve goal nine types water based binder solutions prepared gly liquid binding agent mixed respectively ethylene glycol diacetate egd flow enhancer print quality solutions established quantitatively using image processing algorithm print quality analysis narrowed solutions three batches containing egd variable amount gly solutions used manufacture porous cpp bone substitute samples characterized physically determine shrinkage porosity microstructure compression strength gly egd solution resulted highest mechanical strength sintering mpa illustrating similar mechanical properties compared previous studies mpa additively manufactured cpp bone substitutes using commercially available binder wiley periodicals inc biomed mater res part appl biomater
coronary heart disease leading cause premature death men epidemiological studies shown high prevalence low serum testosterone levels men cardiovascular disease cvd furthermore low testosterone level associated observational studies increase cardiovascular events mortality testosterone beneficial effects several cardiovascular risk factors include cholesterol endothelial dysfunction inflammation key mediators atherosclerosis bidirectional relationship low endogenous testosterone levels concurrent illness complicates attempts validate causality association potential mechanistic actions complex testosterone vasoactive hormone predominantly vasodilatory actions several vascular beds although studies reported conflicting effects clinical studies acute chronic testosterone administration increases coronary artery diameter flow improves cardiac ischaemia symptoms men chronic stable angina reduces peripheral vascular resistance chronic heart failure although mechanism action testosterone vascular tone vivo understood laboratory research found testosterone calcium channel blocker induces potassium channel activation vascular smooth muscle cells animal studies consistently demonstrated testosterone atheroprotective whereas testosterone deficiency promotes early stages atherogenesis translational effects testosterone vitro animal human studies conflicting effects discussed review review evidence role testosterone vascular health therapeutic potential safety hypogonadal men cvd possible underlying mechanisms
quest one dominant processes controlling large scale circulations tropics unraveled impact cloud microphysical processes known effects rainfall local atmospheric thermodynamics however effect prevailing mean circulations yet studied two sets coupled global climate model experiments ice ice microphysics reveal ice microphysics improves strength hadley circulation respect observation results pinpoint ice simulation enhances high cloud fraction global tropics similar india similar stratiform rain global tropics similar india similar contribution ice ice cloud microphysics impacts differently outgoing longwave radiation olr tropospheric temperature surface shortwave longwave radiation effect ice microphysics reduces olr signifies deeper convection ice run global annual average net radiation flux shortwave longwave surface ice run close observation overestimated ice run result apparent heat source term land ocean surface eventually modifies regional hadley circulation thus effect ice microphysics global coupled model important microphysics also due radiation feedbacks therefore better ice phase microphysics required new generation climate forecast model may lead improvements simulation monsoon
philadelphia negative myeloproliferative neoplasms mpn comprise heterogeneous group chronic hematological malignancies significant variations clinical characteristics due long survival feasibility oral subcutaneous therapy patients frequently treated outside larger academic centers analysis performed elucidate differences mpn patients three different health care settings university hospitals community hospitals office based physicians obp mpn registry study alliance leukemia non interventional prospective study including adult patients mpn according criteria statistical analysis descriptive methods tests significant differences used besides different distribution mpn subtypes settings patients contributed showed impaired medical condition higher comorbidity burden vascular complications risk group analyses majority polycythemia vera essential thrombocythemia patients classified high risk category due previous vascular events patients obp settings age major parameter high risk categorization regarding mpn directed therapy patients setting likely receive ruxolitinib within framework clinical trial summary characteristics management patients differed significantly three health care settings higher burden vascular events comorbidities patients contributed differences need taken account analyses design clinical trials
draw accurate relationship power dissipation speed challenging problem operational amplifier switch capacitance however transformation current steer circuit charge steer efficient technique reduce power dissipation even higher speed paper efficient model proposed estimate stage operational amplifier power dissipation delay used design higher order operational amplifier voltage controlled oscillator analog digital converters efficient power cmos circuits analysis stage amplifier bsim model cmos tanner environment done result shows power dissipation reduced approximately stage stage amplifier using charge steering technique
aims incentives represent specific intervention support smoking cessation prevention paper aims assessing effectiveness incentives methods evidence based overview reviews methodological approach involved systematic literature search databases quality assessment systematic reviews results systematic reviews fulfilled inclusion criteria incentives positive effects smoking cessation particularly pregnant women women post partum effects decreased incentives suspended though evidence incentives preventive effect children adolescents conclusions effective smoking restriction necessitates concerted actions combining incentives individuals preventive measures policy level
providing itemized energy consumption utility bill becoming priority perhaps business practice near term recent times multitude systems developed smart plugs smart circuit breakers etc non intrusive load monitoring nilm integrated either smart meters plug levels footprint appliance level energy consumption patterns entire home environment deploying existing technologies single home feasible scaling technological advancements across thousands homes region realized yet primarily due cost deployment complexity intrusive nature associated types real deployment motivated shortcomings paper investigate first step address scalable disaggregation proposing disaggregation mechanism works large dataset accurately deconstruct cumulative signals propose iterative noise separation based approach perform energy disaggregation using sparse coding based methodologies work single ingress point home meter level performed ranked iterative signal removal methodology effectively isolates appliances individual signal waveform noise aggregate energy datasets moderate granularity min performed experiments real dataset obtained approximately energy disaggregation disaggregated appliance wise signal estimation accuracy
image sensors integrated programmable signal processing execute computationally intensive processing steps immediately image acquisition thereby allowing reducing output data relevant features contrast conventional image processing systems tasks image acquisition actual image processing vision chip viewed independently validating architecture supporting programming course application development modeling system level performed part design process vision system chip apart implementation essential components integrated control unit well digital analog signal processing special attention paid integration development environment able purposefully insert parameter deviations defects different points analog processing enables investigations respect influence image processing algorithms performed image sensor due high simulation speed compatibility real system especially regarding executed programs resulting simulation model well suited use application development spie
integrated model simulating diagnosing water quality based system dynamics bayesian network presented paper research aims connect water monitoring downstream outlet management upstream order present efficiency outlet management strategy integrated model built two components system dynamics used simulate water quality applied diagnose reason water quality deterioration according water quality simulation integrated model applied case study songhua river baiqi section songlin section prove reasonability accuracy results showed simulation fit variation trend monitoring data average relative error less water quality deterioration songlin section mainly found caused water quality upper reach hadashan reservoir drain using diagnosis function integrated model based relevant result revealed integrated model could provide reasonable quantitative support basin manager make reasonable outlet control strategy avoid serious water quality deterioration
purpose review chronic obstructive pulmonary disease copd widely prevalent potentially preventable cause death worldwide purpose review summarize influence gender various attributes disease help physicians provide personalized care copd patients recent findings cultural trends smoking morphed epidemiology traditionally male disease increasing disease burden among women copd suggested higher prevalence slower decline death rates compared men biologic differences genders account differences women distinct features need considered boost success therapeutic interventions smoking cessation addressing comorbidities attendance pulmonary rehabilitation summary copd women distinct men respect phenotype symptom burden comorbidities women predisposed develop chronic bronchitis dyspnea suffer frequently coexistent anxiety depression may subject men misdiagnoses underdiagnoses copd often result physician bias knowledge gender differences lead effective tailored care copd patient
dynamic response sphere soft clay considered field tests dia steel sphere allowed free fall water dynamically penetrate underlying soft soil test data collected lake sea environment relate sphere velocities reaching sphere invert embedments close ten diameters inertial measurement unit located within sphere measured motion response sphere free fall penetration soil resulting acceleration data used within simple framework accounts geotechnical shearing resistance fluid mechanics drag resistance cast terms single capacity factor expressed terms non newtonian reynolds number merit framework demonstrated using forward model series inverse analyses calculate undrained shear strength profile acceleration data measured free fall sphere tests good match profiles obtained push piezoball penetrometer tests points potential instrumented free fall sphere used tool characterising near surface strength soft seabeds
setting donation option default charitable appeal affect people decisions eight studies comprising participants making donation decisions experimental settings largescale natural field experiment authors investigate effect choiceoption defaults donation rate average donation amount resulting revenue find scale back effect low defaults reduce average donation amounts lower bar effect defaulting low amount increases donation rate default distraction effect introducing defaults reduces effect cues positive charity information contrary view setting defaults backfire defaults increased revenue field study however findings suggest defaults sometimes self canceling intervention countervailing effects default option magnitude decisions resulting net effect revenue authors discuss implications findings research fundraising specifically choice architecture behavioral interventions generally use nudges policy decisions
introduction hypogonadism growing concern aging male population historically treated using exogenous testosterone concerns possible adverse effects testosterone led physicians seek alternative treatment approaches areas covered enclomiphene citrate trans isomer clomiphene citrate non steroidal estrogen receptor antagonist fda approved treatment ovarian dysfunction women clomiphene citrate also used label many years treat secondary male hypogonadism particularly setting male infertility review literature examining efficacy safety enclomiphene citrate setting androgen deficiency expert opinion initial results support conclusion enclomiphene citrate increases serum testosterone levels raising luteinizing hormone follicle stimulating hormone fsh levels without negatively impacting semen parameters ability treat testosterone deficiency men maintaining fertility supports role enclomiphene citrate treatment men testosterone therapy suitable option
ambient assisted living aal systems based sensor technologies seen key enablers ageing society however approaches space provide truly generic ambient space one capable assisting people diverse medical conditions also recognise habits healthy habitants well developing medical conditions recognition activities daily living adl key understanding provisioning appropriate efficient care however adl recognition particularly difficult achieve multi resident spaces especially single mode albeit carefully crafted solutions limited capabilities address limitations propose multi modal system architecture aal remote healthcare monitoring home gathering information multiple diverse sensor data sources paper report developments made date various technical areas respect critical issues cost power consumption scalability interoperability privacy
study investigated relationship emotional intelligence burnout among architecture students sample study included year students architecture department study emotional quotient inventory bar used measure emotional intelligence profile maslach burnout inventory mbi maslach used measure state burnout level architecture students found upper intermediate score relationship found level students gender habitation employment financial welfare levels burnout status architecture students defined intermediate score relationship found burnout status students gender habitation employment financial welfare levels statistical analysis data revealed strong statistically significant relationship direction emotional intelligence levels students burnout status study also revealed strong statistically significant relationship burnout status general mood stress management subscales emotional intelligence
study produces composite geotextile evaluates effectiveness used soil protection kevlar fibers high strength polyethylene terephthalate hpet fibers recycled polyethylene terephthalate rpet fibers nylon grids made kevlar pet nylon composite geotextiles tested air permeability tensile tearing bursting strength experimental results show ratio kevlar fibers hpet resulting composite geotextile optimum mechanical properties tensile strength approximately tearing strength approximately bursting strength approximately air permeability around
background serum paraoxonase pon enzyme associated high density lipoproteins hdl particles inhibits oxidation serum lipoproteins cell membranes pon activity lower patients atherosclerosis inflammatory diseases systemic inflammatory response provoked cardiopulmonary bypass grafting may contribute development postoperative complications aim present study estimate dynamic changes paraoxonase pon activity towards paraoxon phenyl acetate coronary artery surgery methods twenty six patients coronary heart disease undergoing coronary artery bypass grafting cabg enrolled study venous blood samples obtained preoperatively aortic clumping end operation operation paraoxonase activity measured spectrophotometrically glycine naoh buffer containing paraoxon cacl arylesterase activity measured triscl buffer containing phenyl acetate cacl results pon activity toward paraoxon phenyl acetate significantly decreased aorta cross clumping increased directly operation pon activity towards paraoxon preoperative period pon activity towards phenyl acetate seventh stage experiment tended inversely correlate occurrence postoperative complications conclusion paraoxonase plasma activity markedly reduced cabg surgery
huai river qingling mountain divide divide china north south respect public policies building construction operation practises china building energy efficiency standard mandates air exchange rates north qdivide south divide china heating policy allows space heating systems north divide consequently indoor temperature humidity differ considerably north south theoretical model using indoor temperature humidity air change rate developed predict indoor formaldehyde concentrations data cities obtained studies good agreement literature modelling theoretical reference room united states environmental protection agency epa model applied estimate cancer risk formaldehyde exposure indoors median indoor formaldehyde concentration renovation ever chinese cities higher threshold median indoor formaldehyde concentrations north higher south times higher dwellings renovated within past year times higher renovation ever driven much higher northern winter concentrations epa model predicts lifetime formaldehyde related cancer risk people living north divide times greater people living south partly explained greater indoor exposure formaldehyde chinese living north divide elsevier rights reserved
year old japanese woman admitted saga university hospital fever malaise productive cough six years ago diagnosed bronchial asthma treated inhaled corticosteroids chest radiograph computed tomography admission showed infiltrates right middle lobe mass lesion left lower lobe bronchiectasis lower lobes sputum examination showed grampositive rods phagocytosis neutrophils bacilli identified nocardia otitidiscaviarum ribosomal rna sequencing therefore diagnosed pulmonary nocardiosis treated trimethoprim sulfamethoxazole tmp smx minocycline mino however discontinue antibiotics severe nausea anorexia instead treated fluoroquinolone months resolution disease thereafter pulmonary nocardiosis bronchial asthma bronchiectasis successfully treated fluoroquinolone alternative tmp smx mino
paper studied anti attack performance testing methods large network anti attack performance testing process large networks different traditional testing process mainly features harbinger attacks lacking precise characteristic information determining attack act point point structure limit characteristics connections traditional detection method focuses fixed feature information directly linked take anti attack performance testing lost contact feature cause detection inaccuracy order avoid shortcomings paper proposed anti attack performance testing method large networks based fuzzy means clustering algorithm collected relevant data extract analysis sample characteristics use fuzzy means clustering method classification data calculations gain abnormal behavior pattern data complete anti attack performance testing large network experimental results showed using proposed algorithm anti attack performance testing large network could greatly improve accuracy detection effectively maintain large network security provide users good network environment
hepatitis virus hcv infection public health issue worldwide injecting drug use remains major mode transmission developed countries monitoring hcv transmission dynamic time crucial especially assess effect harm reduction measures drug users objective estimate prevalence incidence hcv infection france using data repeated cross sectional survey conducted ageand time dependent hcv prevalence estimated logistic regression models adjusted hiv serostatus injecting practices hcv incidence estimated mathematical model linking prevalence incidence hcv prevalence decreased confidence interval hcv incidence decreased person years person years hcv prevalence incidence significantly associated age calendar time hiv serostatus injecting practices highest estimated incidence active injecting person years given forthcoming objective generalizing access new direct antiviral agents hcv infection results contribute decision making policy development regarding treatment scale disease prevention population
nurse stress literature reports overwhelming culture acceptance expectation work stressors ironically linked control workplace effectively proactively manage stress stressors involved delivering stress management well studied nursing related workplaces especially acute care settings accordance karasek job demand control support jdcs model however little known effects specificity acute care unit level qualifications stress experienced nurses survey using jdcs model conducted among nurses working three different acute care units anesthesiology emergency intensive care unit university hospital specific questions explored variables gender acute care units level qualification working experience two hundred questionnaires returned high level job strain highlighted without gender effect absence isostrain nurses acute care units located high stress quadrant jdcs model conversely nurses commonly located active quadrant independent acute care settings highest level education associated highest job strain lowest level control acute care setting high level education key factor high job stress associated perception low control workplace may predictors adverse mental health particular lack control associated moral distress frequently reported characteristic acute care settings enhance personal professional outcomes advanced registered nurses strategies supporting nurses manage daily stressors acute care urgently required
despite growing need educational tools support students earliest phases undergraduate computer science curricula relatively tools exist majority intelligent tutoring systems since peer interactions readily give rise challenges negotiations another way students become interactive problem solving created artificial peer collaborator determine value aiding students central development notion monitor student collaborative behavior attempt guide towards productive behavior prior work found initiative shifts correlate knowledge construction kcc learning potentially easier model indicator productive collaboration instructional software paper describe unique peer dialogue agent created test effects tracking reacting initiative shifts study find differences learning gains comparing agents track react initiative shifts find students learn interacting agent attempting influence initiative taking make difference suggests tracking initiative shifts agent able detect times student letting agent deep thinking agent tactics encouraging student begin taking initiative helpful
present study examined timing suicide associated soldier background postinvestigative events among deployed army national guard arng soldiers calendar years suicide deaths nearly equally distributed soldiers deployed among deployed however suicides occurred mostly year returned deployment soldier background postsuicide investigative events associated timing suicide years military service previous deployments married associated theater suicides soldiers younger age years single nonprior service lower rank addition parent family conflicts full time employment problems military transition problems associated suicides occurred days days since return deployment soldiers aged years married higher rank along reported problems including past behavioral health conditions postdeployment behavior health referrals criminal behaviors military performance associated suicides occurred year return findings likely represent time periods suicide vulnerability identifiable groups soldiers based soldier background events surrounding suicide practical theoretical implications findings discussed
purpose receptor signaling molecule important role regulation lymphocyte activity correlation gene pdcd polymorphisms immune related diseases reported current study aimed investigate association polymorphisms positions well emerged haplotypes susceptibility thyroid carcinoma methods one hundred five patients confirmed thyroid cancer healthy individuals control group enrolled genotypes identified using pcr rflp nested pcr rflp methods results analyzed arlequin spss software packages results analysis revealed significant increase frequency mutant allele heterozygous genotype patients thyroid cancer comparison controls receptively genotype position observed significantly higher among controls patients significant differences frequencies genotypes alleles locus patients control group despite haplotype emerged positions also observed significant increased frequency patients controls conclusion first study investigate two mentioned polymorphisms thyroid cancer current study confirmed association polymorphism haplotype resulted loci susceptibility iranians thyroid cancer
year american centers medicare medicaid cms pays graduate medical billion dollars graduate medical education usa education lack evidence based research effectiveness amer learner centered ican osteopathic trainees learn taught outcomes based delivery system education proven important tool measuring status graduate medical competency based education gme america competency based medical education cbme medical education shown important part international medical education system since teaching acgme american council graduate medical education started measuring six core competencies decade ago questions arisen regarding traditional residency training methods benefits since single accreditation system acgme aoa american osteopathic association put effect july best time osteopathic community nationally internationally take look teaching residents within article faculty training residents reflective practices assessment professionalism specifically focused utmost importance research reevaluate medical education curriculum able help meet needs future generations also graduating competent globally engaged professional physicians article seeks show need innovation osteopathic gme role competency based medical education cbme play osteopathic profession meet need elsevier ltd rights reserved
many solutions developed convert non rdf data rdf common task conversion applying data manipulation functions obtain desired output depending data format source transformed one rely underlying technology rdbms relational databases xquery xml manipulate data certain extent generating rdf csv files however underlying technology instead one resort elaborate extract transform load etl processes render generation rdf complex terms number steps therefore also less traceable transparent one solution problem declaration inclusion functions mappings non rdf data rdf paper propose method incorporate functions mapping languages demonstrate viability digital humanities use case
paper proposes novel inerter based electromagnetic device investigates performance vehicle suspension strut inerter based electromagnetic device obtained placing flywheel employed existing inerter prototype constant magnetic field rotation flywheel flywheel magnetic line cutting motion makes flywheel perform faraday generator influences different types loads behaviour inerter based electromagnetic device analyzed shown resistive capacitive inductive loads contribute damping inertance stiffness whole device respectively moreover proposed device also used realize higher order mechanical admittances using electrical circuits performance device suspension strut also studied numerical simulations show proposed device provide improvements suspension performance ride comfort road holding compared conventional strut also generate amount electric energy utilized parts vehicle
work thin film sige synthesized solid source molecular beam epitaxy identified ray diffractometry raman spectroscopy effect fraction structural electrical conduction relaxation studied detail using impedance analysis results modulus study reveal presence two distinct relaxation processes suggesting presence grains grain boundaries sample value exponent calculated plot log sigma versus log ranges suggested conduction phenomena studied samples pursue hopping conduction impedance data well fitted two equivalent electrical circuits confirms presence two distinct relaxation processes results indicate sige thin films fabricated method applicable sige based electronic optical devices moreover fabrication high quality sige thin films thin film enables application solar cell elsevier rights reserved
paper methodology estimating regression model locally stationary errors proposed particular consider models two features time varying trends errors belonging class locally stationary processes proposed procedure provides efficient methodology estimating predicting handling missing values non stationary processes consider truncated infinite dimensional state space representation kalman filter algorithm estimate parameters model suggested monte carlo simulation studies performance kalman filter approach good even small sample sizes finally proposed methodology used two real life applications elsevier rights reserved
previous studies shown fibromyalgia syndrome fms associated low level physical activity exercise may lead increased risk osteoporosis however studies bone mineral density bmd fibromyalgia shown conflicting results thus conducted systematic review meta analysis better characterize association fms bmd comprehensive search databases medline embase performed inception may inclusion criterion observational studies assessment association fibromyalgia bone mineral density adult subjects fibromyalgia diagnosed accordance american college rheumatology criteria diagnosis fibromyalgia syndrome bmd measured lumbar spine femoral neck dual energy ray absorptiometry pooled mean difference bmd site confidence interval calculated using random effect generic inverse variance method study heterogeneity effect size quantified using statistic data extracted four observational studies involving subjects lumbar spine bmd significantly decreased patients fms compared controls pooled value fig femoral neck bmd significantly decreased patients fms compared controls pooled value fig meta analysis observe bmd lumbar spine decreased fms compared normal individuals patients fms assessed risk osteoporosis
multi walled carbon nanotube mwnt many commercial applications however broad use limited surface bound oxygen lowering thermal stability developed facile method enhance oxidative thermal resistance mwnts involves molecular coating promoted surface passivation approach ball milling employed self assemble flavin mononucleotide fmn helically around mwnts non covalent interactions increased defects mwnt upon high temperature oxidation ribityl phosphate side chain fmn nanoconstruct undergoes partial decomposition generate corresponding isoalloxazine derivative surface mwnts transmission electron microscopy reveals oxidatively annealed material comprised tight isoalloxazine coating stacked sidewalls mwnt results thermal gravimetric analysis studies show coating elevates long term stability energy barrier oxidation mwnt mol mol bare mwnt role isoalloxazine coating proposed surface passivation molecular oxygen consequence passivation maximum oxidative temperature mwnt raised compared bare mwnt elsevier ltd rights reserved
postmortem brain studies support dysregulated expression histone deacetylase enzymes hdac hdac central feature diseases including schizophrenia bipolar disorder depression objective investigate hdac expression large postmortem sample set representing healthy disease brains used well characterized samples patients diagnosed schizophrenia major depressive disorder bipolar disorder measure hdac hdac transcript levels quantitative real time pcr dorsolateral prefrontal cortex dlpfc caudate compared control samples hdac expression calculated relative geometric mean beta microglobulin beta glucuronidase beta actin adult age dlpfc hdac decreased schizophrenia samples compared controls hdac significantly upregulated major depressive disorder samples versus controls neither smoking history therapeutic drugs impacted hdac levels hdac patient control differences observed caudate hdac levels unchanged patient control groups control dlpfc age fetal week years hdac hdac levels sharply declined around birth stabilized thereafter using far largest postmortem sample set topic major finding decreased hdac transcript showed notable specificity disease schizophrenia major depressive disorder hdac subtype hdac hdac brain region dlpfc caudate differences shape understanding regional components neural circuitry diseased brain set benchmark quantify hdac density distribution using vivo neuroimaging tools
tachyarrhythmias bradyarrhythmias often seen outpatient setting patients present minimally symptomatic extremis accurate diagnosis rhythm plus detailed clinical history critical best management optimal outcome lead electrocardiogram cornerstone diagnosis practitioners must identify patients need immediate transport emergency department versus safely wait outpatient specialty referral article reviews accurately diagnose differentiate common tachyarrhythmias bradyarrhythmias associated symptoms important concepts initial steps office management arrhythmias
paper presents cycle efficient software frequency response analyzer sfra integrated firmware digitally controller power converter measure frequency response plant open loop gain closed loop system algorithm uses readily available measurements taken power stage control require additional hardware enables periodic measurement frequency response used monitor changes power converter proposed technique run conventional microcontroller without host intervention adds cost system important cost sensitive power converters floating point fixed point implementation compared enabling widespread applicability technique order validate efficacy analyzer synchronous buck power converter designed control transfer function compared measured online frequency response algorithm outlined fit measured sfra data pole zero format intelligent cost function estimation correlation zeros poles identified using method modeled plant transfer function analyzed dual core approach discussed run sfra high switching frequency converter thus showing applicability technique high switching frequency converters
targeted approaches treatment severe enduring anorexia nervosa recommended consensus definition inform research clinical practice study aimed take initial steps toward developing empirically based definition characterizing associations among putative indicators severity chronicity eating disorders patients completed interviews questionnaires treatment admission discharge height weight assessed calculate body mass index bmi structural equation mixture modeling used test whether associations among potential indicators illness duration treatment history bmi binge eating purging quality life formed distinct subgroups single group one dimensions combination subgroups dimensions three factor dimensional two profile categorical mixture model provided best fit data factor included eating disorder behaviors factor comprised quality life domains factor characterized illness duration number hospitalizations admission bmi profiles differed eating disorder behaviors quality life indicators chronicity bmi factor scores profile membership predicted outcome discharge treatment data suggest patients classified basis eating disorder behaviors quality life evidence chronic subgroup rather indices chronicity varied dimensionally within class given current definitions rely illness duration findings implications research clinical practice
paper show two applications generalization lambert function explicit calculations given inverse langevin function plays important role study paramagnetic materials dispersion equations water waves examples provide additional knowledge generalized lambert function well review former studies made towards direction authors
introduction affordable care act aca expansion mandated private health plans cover women preventive services starting august limited contradictory evidence study intends assess impact aca utilization rates cost burden women reproductive preventive service methods pre post analysis conducted using nationally representative sample females aged years participating national survey family growth utilization rates cost burdens compared six services using bivariate multivariable logistic regression models results aca expansion significant increase utilization rates birth control prescription birth control counseling sterilization counseling sti counsel test treat hiv screening respondents paying insurance increased aca pocket spending cost sharing decrease respondents type insurance important predictor utilization rates publicly insured significantly higher odds ratio likelihood receiving birth control counseling sterilization counseling sti counsel test treat hiv screening compared privately insured conclusions early impact aca expansion utilization rates women reproductive preventive services appear significant private health plans however might expanded coverage burden cost sharing still existed future research evaluate long term impact aca expansion women health economic gains elsevier inc rights reserved
topology optimization important topic structural mechanics one common application obtain optimal distribution material maximizes stiffness solution minimize compliance however iterative process topology optimization large complex structures computationally intensive problem becomes even complicated manufacturing constraints taken account optimization process paper novel growth method based principal stress lines psls presented topology optimization psls traced design domain along direction principal stresses materials would located define geometry topology structure consequently optimization problem converted geometric design problem compared previous methods computation based psls fast designer explicit control number structural members addition manufacturing constraints easily incorporated multiple test cases given illustrate presented method psl based method promising building practical designing tools various structural applications elsevier ltd rights reserved
background direct acting oral anticoagulants doacs used patients splanchnic vein thrombosis svt cirrhosis evidence safety efficacy setting limited aim identify indications reasons starting switching doacs report adverse effects complications short term outcome methods data collection including demographic information laboratory values treatment complications vascular liver disease interest group consortium results forty five centres consortium completed initial ecrf report series patients centres thirty six patients cirrhosis child pugh score range meld score range indications anticoagulation splanchnic vein thrombosis deep vein thrombosis atrial fibrillation others doacs used rivaroxaban dabigatran apixaban patients followed median duration months cirrhotic months non cirrhotic adverse events occurred patients included one case recurrent portal vein thrombosis five cases bleeding treatment doacs stopped three cases major reasons choosing doacs need monitoring inadequacy inr guide anticoagulation cirrhotic patients renal liver function change treatment conclusions consistent number patients svt cirrhosis currently treated doacs seem effective safe data provide basis performing randomized clinical trials doacs low molecular weight heparin vitamin antagonists
introduction hiv treatment guidelines recommend initiating antiretroviral therapy art regardless cell count barring contraindications barriers treatment estimated persons receiving hiv care prescribed art examined reasons gap care continuum methods surveyed probability sample hiv care providers returned surveys adjusted response rate estimated percentages providers followed guidelines characteristics deferred art prescribing reason results barring contraindications providers initiated art regardless count providers less likely initiate caseloads patients adjusted prevalence ratios apr confidence interval practiced non ryan white hiv aids program funded facilities apr reported pharmaceutical assistance programs provided insufficient medication meet patients needs apr never deferred prescribing art deferred patients deferred among providers deferred art cited patient refusal reason cases reported adherence concerns mental health disorders substance abuse reported adherence concerns social problems homelessness factors cases deferring art conclusions estimated hiv care providers adopted recommendations initiate art regardless count barring contraindications barriers treatment low volume providers non ryan white hiv aids programfunded facilities less likely follow guideline among providers leading reasons deferring art included patient refusal adherence concerns
stark contrast online advertising campaigns advertisement urban space lost attention seems stuck gutenberg era emergence hybrid urban spaces however allows novel possibilities bring back customers attention interest publication review current interactive advertisement campaigns investigate use implicit age gender location explicit gestures interactions user adjust discuss novel questions responsibilities driven new advertisement formats evaluate different aspects behavior acceptability novel kind advertisement built prototypical system put shopping mall conducted user study includes random visitors mall first tested system filled questionnaire
schiff base indol methylene aminobenzohydrazide iabh complexes synthesized compounds characterized different physico chemical spectroscopic tools vis nmr esi mass molecular structure iabh determined single crystal ray diffraction technique ligand iabh displays configuration bond structure ligand stabilized intra molecular bonding metal complexes ligand coordinates azomethine carbonyl resulting distorted octahedral geometry complexes chloride ions occupy axial positions complexes however form coordinate distorted square planer tetrahedral geometry around metal ion respectively structures complexes satisfactorily modeled calculations based density functional theory dft time dependent dft dft corrosion inhibition study compounds performed mild steel hso solution using weight loss potentiodynamic polarization electrochemical impedance spectroscopy eis show appreciable corrosion inhibition property elsevier rights reserved
photovoltaic cell plays crucial role utilize solar energy regional differences industry created unbalanced flows cells paper examined patterns cells international trade spatial temporal perspectives data sources regional monetary importexport tables world renewable energy statistics based haggett cognitive model spatial structure patterns evolution characteristics identified aid arcgis study revealed cells exporters distributed east asia southeast asia intensively whereas relatively balanced exports presented europe north american recent years cells flowing east west pattern cells international trade transformed single pole multi pole meanwhile international trade intensity cells grew steadily global scale evolution features cells trades varied region region economics conditions incentive policy producers demand three critical factors findings provide useful reference identifying intensity orientation main connections development trend traders moreover industrial practitioners benefit research develop corresponding international business strategies elsevier ltd rights reserved
background nurse practitioners increasingly integrated primary care delivery help meet growing demand primary care therefore important understand nurse practitioners productivity primary care practice purpose examined nurse practitioners clinical productivity regard number patients seen per week whether patient panel patient panel size investigated practice characteristics associated clinical productivity methods conducted cross sectional analysis national sample survey nurse practitioners sample included full time primary care nurse practitioners ambulatory settings multivariable survey regression analyses performed examine relationship practice characteristics nurse practitioners clinical productivity results primary care nurse practitioners ambulatory settings saw average patients per week confidence interval patient panel average patient panel size nurse practitioners patient panel spent similar percent time patient care documentation however patient panel likely provide range clinical services patients nurse practitioners clinical productivity associated several modifiable practice characteristics practice autonomy billing payment policies discussions estimated number patients seen typical week nurse practitioners comparable primary care physicians reported literature however significantly smaller patient panel nurse practitioners clinical productivity improved
small scale geologic inhomogeneities discontinuities tiny faults cavities fractures generally spatial scales comparable even smaller seismic wavelength therefore seismic responses objects coded diffractions attempt high resolution imaging made appropriately image amplitudes reflections several orders magnitude larger diffractions one key problems diffraction imaging suppress reflections time preserve diffractions sparsity promoting method separating diffractions common offset domain proposed uses kirchhoff integral formula enforce sparsity diffractions linear radon transform formulate reflections subspace trust region algorithm provide globally convergent solutions employed solving large scale computation problem method allows separation diffractions case interfering events also ensures high fidelity separated diffractions numerical experiment field application demonstrate good performance proposed method imaging small scale geological features related migration channel storage spaces carbonate reservoirs
broad use business process management technology business process models since ability different modelers different quality models varies question arises refactor models improve quality practised software engineering business process modeling regarded declarative programming business process models used drive process aware information systems generally developed model driven architecture business process models crucial efficiency process aware information systems paper propose novel approach systematically refactor business process models parallel structures sequence structures first time specifically analyze real causal relations business tasks based data operation dependency analysis refactor business process models process mining technology comprehensive model refactoring parallel execution business tasks maximized efficiency business processing improved quality business process models improved analysis experiments show approach effective efficient
complexity increase software hardware necessary support advanced applications wireless sensor networks conspicuously contribute render susceptible security attacks nodes complex wsn applications sport desktop level operating systems reliance software make ideal prey traditional threats like viruses general malware address problems paper devise system dedicated mobile node locate track access cure infected elements wsn threatened proximity malware infection parallel provide mathematical formulation aforementioned operations perform extended simulations comparing proposal classic solutions different network scenarios use results mathematical formulation benchmark furthermore introduce variation proposal capable support concurrent operation multiple mobile nodes implement cooperation elsevier rights reserved
background treatment guidelines asthma established based asthma severity limitations identification underlying pathophysiology prediction prognosis heterogeneous phenotypes asthma although complex interactions environmental genetic factors affect development progression asthma studies asthma phenotypes considering environmental factors limited study aimed identify asthma phenotypes using latent class analysis including environmental factors school age children methods included children years parent reported physician diagnosed asthma children health environmental research cheer study year prospective follow study year intervals every survey pulmonary function tests methacholine challenge tests blood tests questionnaire conducted results four asthma phenotypes identified cluster children characterized high prevalence atopy mild symptoms subjects cluster consisted less atopy normal lung function intermittent troublesome cluster experienced late onset atopic troublesome asthma decreased lung function combination low socioeconomic status cluster associated early onset less atopic infrequent asthma conclusions late onset high atopy low socioeconomic status associated troublesome persistent asthma phenotype school age children environmental factors might implicated clinical heterogeneity asthma asthma phenotypes considering diverse factors might helpful identification asthma pathogenesis prevention
objective irritable bowel syndrome ibs associated high prevalence psychological disorders coping used manage stressful events adaptive maladaptive effects patient health status however coping behaviors well studied individuals ibs association use coping behaviors reported levels depressive symptoms examined individuals ibs methods among volunteers men women participated iwaki health promotion project included subjects fulfilled rome iii criteria ibs analysis coping behaviors assessed using brief scale coping profile bscp center epidemiologic studies depression scale ces used assess four dimensions depressive symptoms depressed affect somatic symptoms interpersonal problems lack positive affect prevalence probable depression using cut score results among subjects ibs exhibited probable depression adjustment confounders active solution found significantly associated somatic symptoms conditions avoidance suppression significantly associated ces total score depressed affect somatic symptoms lack positive affect significant relationships depressive symptoms bscp sub scale scores conclusion findings indicate coping behaviors may influence experience depressive symptoms among individuals ibs psychological therapy may reduce depressive symptoms well severity ibs symptoms additional studies needed examine relationships coping behaviors depressive symptoms using longitudinal study design
use prefabricated modules potential increase efficiency onsite construction activities well adaptability buildings however modules currently require degree repetitiveness many clients object resolve conflict graph based methodology proposed decomposes design non repetitive modules preassembled offsite without restricting design advance modules contain components similar future replacement rates limited number connections components clustering algorithm applied data bim tools optimal definition modules interfaces computer program developed allow automated application methodology large complex projects research demonstrates graph based models useful representing analyzing construction projects graph based approach potential successfully applied additional areas order provide project management tools elsevier rights reserved
background understanding smoking cessation treatments exert effects inform treatment development use factorial designs allow researchers examine whether multiple intervention components affect hypothesized change mechanisms whether affected mechanisms related cessation methods secondary data analysis smokers recruited primary care visits women white motivated quit participants fractional factorial experiment randomized one level six intervention factors prequit nicotine patch none pre quit nicotine gum none preparation counseling none intensive person counseling minimal intensive phone counseling minimal weeks combination nicotine replacement nicotine patch nicotine gum data putative mechanisms medication use withdrawal self efficacy smoking status gathered using daily assessments follow assessment calls results intervention components influenced hypothesized mechanisms prequit gum patch reduced prequit smoking enhanced prequit coping self efficacy person counseling increased prequit motivation quit postquit self efficacy postquit perceived intratreatment support withdrawal reduction reduced prequit smoking produced strongest effects cessation significant effect combining prequit gum person counseling week abstinence mediated increased prequit self efficacy conclusions factorial experiment identified putative treatment mechanisms influenced discrete intervention components mechanisms influenced cessation information supports combined use prequit nicotine gum intensive person counseling cessation interventions operate via increased prequit self efficacy elsevier ireland ltd rights reserved
although robots becoming ever growing presence society hold expectations robots humans treat ability recognize cues human animacy fundamental guiding social interactions review literature demonstrates cortical networks associated person perception action observation mentalizing sensitive human animacy information addition show prior research explored stimulus properties artificial agents humanness appearance motion less investigation knowledge cues whether agent believed human artificial origins therefore currently little known relationship stimulus knowledge cues human animacy terms cognitive brain mechanisms using fmri elaborate belief manipulation human robot avatars found knowledge cues human animacy modulate engagement person perception mentalizing networks stimulus cues human animacy less impact social brain networks findings demonstrate self similarities grounded physical features also shaped prior knowledge broadly artificial agents fulfil increasingly social roles challenge roboticists manage impact pre conceived beliefs optimizing human like design
purpose article elucidate development problem nonverbal means communication condition reflection formation communication children speech underdevelopment research technique characterise nonverbal encoding decoding nonverbal means communication offered authors experimental study nonverbal encoding decoding carried also analysis obtained experimental data provided authors published elseiver ltd open access article license
aimsto determine comorbidity patterns treatment seeking substance use disorder sud patients without adult attention deficit hyperactivity disorder adhd emphasis subgroups defined adhd subtype taking account differences related gender primary substance abuse designdata obtained cross sectional international adhd substance use disorder prevalence iasp study settingforty seven centres sud treatment countries participantsa total treatment seeking sud patients measurementsstructured diagnostic assessments used disorders presence adhd assessed conners adult adhd diagnostic interview dsm caadid presence antisocial personality disorder aspd major depression hypo manic episode hme assessed mini international neuropsychiatric interview plus mini plus presence borderline personality disorder bpd assessed structured clinical interview dsm axis scid findingsthe prevalence dsm adult adhd sud sample aspd odds ratio confidence interval bpd alcohol drugs patients alcohol primary substance abuse hme prevalent adhd compared adhd patients results also indicate increased levels bpd alcohol compared drugs primary substance abuse comorbidity patterns differed adhd subtypes increased inattentive combined subtype increased hme aspd hyperactive impulsive combined subtypes increased bpd subtypes compared sud patients without adhd seventy five per cent adhd patients least one additional comorbid disorder compared sud patients without adhd conclusionstreatment seeking substance use disorder patients attention deficit hyperactivity disorder high risk additional externalizing disorders
split parallel hybrid electric vehicle hev particular sub type hev internal combustion engine ice electric motor provide propulsion power different axles due coupling power vehicle wheels road moves rather mechanical device vehicle referred road ttr hybrid variant ttr hybrid motors hub otherwise non driven wheels called wheel motors iwm configuration enables existing vehicle converted hybrid vehicle minimal modification present work identifies specific operating modes power flow ttr iwm hybrid specifically retrofit conversion hybrid comparison ordinary parallel hybrid vehicle discusses control architecture control objectives system parameters along specific control issues retrofit ttr iwm hybrid vehicle
background accepted regulatory cells treg control different types immune responses connection role recently described important increase high foxp lymphocytes airway system horses coursing exacerbation severe equine asthma explore potential role population resolution inflammation used murine experimental model airway neutrophilic inflammation similar observed induced mice continual exposure aspergillus fumigatus contaminated hay model advantage mice may induce reduction treg population using low doses cyclophosphamide results results indicated percentage treg cells increased allergen exposure horses animals partially depleted treg cells treatment showed increased airway inflammation demonstrated increased percentage neutrophils specific immunoglobulins bronchoalveolar lavage fluid balf furthermore histopathologic study animals pretreated antigenic challenge showed higher cellular infiltration lung deeper remodeling changes bronchi including epithelial goblet cell hyperplasia well airway smooth muscle hypertrophy conclusion murine model reduced number function treg induced low doses directly correlates increased airway inflammation lung infiltration indicates treg may play major role regulation resolution
analog signal processing integrated circuit microcantilever array designed pressure measurement biomedical applications chip consists analog multiplexer instrumentation amplifier sample hold circuit chip voltage current references successive approximation register analog digital converter adc digital control unit root sum square rss error overall pressure measurement system including microcantilever array application specific integrated circuit asic kpa within measurement range kpa bit adc attains signal noise distortion ratio sndr spurious free dynamic range sfdr operating khz integrated circuit fabricated using poly metal cmos process technology chip occupies area consumes power single supply
present study focuses use lubricating oil coolant electrical motors oil introduced side test machine directly cool stator coil end windings experimental setup implemented test different oil injection patterns influence oil flow rate rotation speed oil temperature investigated degrees oil degrees omega rpm results show strong dependence flow rate global cooling performance whereas effect rotation speed smaller affect local temperature elsevier ltd rights reserved
daylight fundamental architecture renovations modernizations transformations cities buildings fundamental people well paper describes significance daylight people based qualitative research project denmark use windows among families show daylight perceived used coped negotiated people homes thus exploring social character natural phenomenon metaphor used biomimetics claiming like plants danish participants need daylight people day day entanglements daylight illustrated highlighting social qualities daylight paper concludes access daylight vital existential reasons health social reasons feel connected one natural environment showing window much technical artefact based argue window acknowledged vital creating dwelling inclusion bio inspired design biophilic architecture far focused inclusion nature views greenery less daylight
cryptococcus neoformans yeast capped fungus marked neurotropism causal agent cryptococcosis deep fungal infection sub acute chronic course considered opportunistic cryptococcal meningitis presents distinctive clinical characteristics cases acquired hospital develops sub acutely treated fatal weeks reasons decided publication case year old female patient brought gustavo aldereguia hospital cienfuegos headache loss consciousness questioning information personal antecedent headaches without apparent cause time ago admitted conscious icu tests performed among microbiological study cerebrospinal fluid blood culture samples taken according standards established cryptococcus neoformans isolated unfortunately diagnosed patient died
paper deals study unconventional design marine tidal turbine electrical generator located periphery blades magnetic gap underwater kind solution called rim driven structure allows increasing compactness robustness system due strong interaction multi physical phenomena electromagnetic model thermal model generator associated hydrodynamic model blades water flow underwater air gap models used global coupled design approach order optimize constraints global efficiency system approach illustrated case study deals design diameter tidal turbine proposed coupled models validated comparison experimental data tests academic low power demonstrator
background rhinoconjunctivitis specific quality life often reduced seasonal allergies mini rhinoconjunctivitis quality life questionnaire mrqlq validated tool used measure quality life people experiencing allergies troubled extremely troubled probiotics may improve quality life allergy season increasing percentage regulatory cells tregs inducing tolerance objective objective study determine whether consuming lactobacillus gasseri bifidobacterium bifidum longum compared placebo would result beneficial effects mrqlq scores throughout allergy season individuals typically experience seasonal allergies secondary outcomes included changes immune markers part potential mechanism changes mrqlq scores design double blind placebo controlled parallel randomized clinical trial participants mean sem age self identified seasonal allergies received either probiotic capsules billion colony forming units capsule placebo spring allergy season mrqlq scores collected weekly throughout study fasting blood samples taken subgroup placebo probiotic baseline week predicted peak pollen determine serum immunoglobulin concentrations treg percentages results probiotic group reported improvement mrqlq global score baseline pollen peak compared placebo group serum total ige percentage tregs increased baseline week changes different groups conclusions combination probiotic improved rhinoconjunctivitis specific quality life allergy season healthy individuals self reported seasonal allergies however associated mechanism still unclear trial registered clinicaltrials gov nct
adolescents spend significant part leisure time watching programs movies portray violence unknown however extent violent media use severity aggression displayed affect adolescents brain function investigated skin conductance responses brain activation functional brain connectivity media violence healthy adolescents event related functional magnetic resonance imaging experiment subjects repeatedly viewed normed videos displayed different degrees aggressive behavior found downward linear adaptation skin conductance responses increasing aggression desensitization towards aggressive videos results revealed adaptation fronto parietal network including left lateral orbitofrontal cortex lofc right precuneus bilateral inferior parietal lobules showing downward linear adaptations desensitization towards aggressive videos granger causality mapping analyses revealed attenuation left lofc indicating activation viewing aggressive media driven input parietal regions decreased time aggressive videos conclude aggressive media activates emotion attention network capability blunt emotional responses reduced attention repeated viewing aggressive media contents may restrict linking consequences aggression emotional response therefore potentially promotes aggressive attitudes behavior
present research drawing intergroup helping power relations model nadler investigated ways different forms helping behavior strategically affect responses women men display socially valued devalued characteristics participants read scenarios concrete problems faced woman man need displayed positive prosocial negative antisocial characteristics indicated extent would willing support small tax increases money used help address target issues predicted target gender target history type support interaction controlling political orientation obtained eta participants tended give less autonomy oriented empowering help man displaying antisocial prosocial characteristics eta also tended dependency oriented disempowering help woman women exhibiting prosocial antisocial qualities eta role seemingly positive forms social behavior mechanism social control relation helping processes group hierarchy system justifying processes considered
solving process control engineering problems treated time series fast accurate self organization learning strategy proposed based significance evaluation hidden neurons respect network output approach introduced optimize architecture parameters span lateral inhibition neural network linn simultaneously insignificant neuron pruned automated step step based determination significance index proposed self organizing approach tested one time series prediction benchmark problem simulation results demonstrate proposed method good exploration exploitation capabilities terns searching optimal structure parameters linn ifac international federation automatic control hosting elsevier ltd rights reserved
searching necessary tool managing navigating massive amounts data available today information age new searching methods become increasingly popular reliable recent years image based searching methods may limited text based means allow generic user input sketch based searching method allows users draw generic search queries return similar drawn images giving user control search content paper present sketchseeker system indexing searching across large number sketches quickly based similarity sketchseeker introduces technique indexing sketches extremely compressed representations allows fast accurate retrieval augmented multilevel ranking subsystem sketchseeker tested large set sketches existing sketch similarity metrics shows significant improvements terms storage requirements speed accuracy
irritant contact dermatitis icd chronic relapsing skin disease severe eczematous lesions despite growing prevalence therapeutic treatments remain limited long term topical corticosteroid treatment induce skin atrophy hypopigmentation increase transepidermal water loss innovative dermal treatment essential reduce side effects corticosteroids topical resveratrol res although effective icd challenging molecule due low solubility poor bioavailability objective work build res loaded solid lipid nanoparticles res slns skin targeting purpose res slns prepared using probe ultrasonication method utilizing precirol ato tween res slns evaluated particle size entrapment efficiency transmission electron microscopy tem studies res slns incorporated carbopol gel investigated vivo skin permeation deposition study human cadaver skin finally skin irritation study new zealand white rabbits assessed possible beneficial effects icd using balb mice ressln showed mean size tem studies confirmed spherical particles nanometer range vivo study res sln loaded gel exhibited controlled drug release similarly vitro drug deposition studies showed potential skin targeting skin irritation ressln gel confirmed competent suppression ear swelling reduction skin water content balb mouse model icdwhen compared tomarketed gel thus formulated res sln gel would safe effective alternative conventional vehicles treatment icd
present paper ultrafast scalable parallel program radial pair function rpf presented via pure message passing interface mpi paradigm parallel code computes radial distribution function single component well multi component systems single component multi component systems extracted benchmarking purposes means user written codes graphite structure mpi hydrogen adsorption via grand canonical monte carlo gcmc single walled carbon nanotube swnt respectively speedup efficiency curves substantiate excellent performance terms computing time computation size well additionally mentioned mpi paradigms nearly five times single component systems two times multi component systems faster relevant parallel codes using machine cpus nvidia quadro pcie sse conclusions outlooks pertaining numerical implementations algorithm optimization involving space decomposition idea discussed provided
objective estimated proportion smokers low socioeconomic status ses methods used data national supplement attitudes behaviors survey health tabs periodic population survey colorado adults estimated smoking prevalence total smokers education poverty level occupation health insurance status combinations factors results smoking prevalence across low ses categories ranged combining low ses categories highest smoking prevalence accounted adults half smokers combining low ses categories regardless smoking prevalence accounted roughly half adults nearly three fourths smokers conclusions majority continuing smokers low ses progress cigarette epidemic depends focusing tobacco research program initiatives reaching engaging smokers cessation strategies work
background investigate relationship depression overactive bladder oab urinary incontinence symptoms among clinical oab population methods patients diagnosed overactive bladder oab age matched control subjects without oab enrolled depression symptoms assessed using hospital anxiety depression scale hads oab incontinence symptoms assessed using validated questionnaires iciq iciq oab udi iiq oab results oab patients study depression hads oab patients moderate severe depression hads oab patients reported significantly higher hads depression scores compared age matched controls versus oab patients depression reported severe incontinence symptoms iciq greater bother impact quality life udi iiq compared oab patients without depression respectively however differences iciq oab oab among oab patients positive correlations severity depression symptoms oab incontinence symptoms values conclusions oab patients depression oab patients depression reported severe urinary incontinence symptoms greater bother impact quality life compared without depression future studies needed examine mechanistic links depression oab urinary incontinence
objective nation wide study adult koreans aimed provide characteristics medical utilization states survival rates newly diagnosed patients primary nonmalignant malignant spine tumors methods data patients primary spine tumors selected korean health insurance review assessment service database data included age sex health insurance type morbidities medical cost hospital stay duration hospital stay duration medical costs per person occurring one calendar year used addition survival rates patients primary malignant spine tumors evaluated results incidence rate primary spine tumor increased age year diagnosis average annual medical costs ranged usd pelvis sacrum coccyx tumors usd spinal cord tumor primary nonmalignant spine tumor usd spinal meningomas usd pelvis sacrum coccyx tumors primary malignant spine tumor overall survival rates primary malignant spine tumor months respectively cox regression model results showed male sex medicare insurance significantly positive factors affecting survival diagnosis primary malignant spine tumor conclusion study provides detailed view characteristics medical utilization states survival rates patients newly diagnosed primary spine tumors korea
several conflicting criteria exist building design optimization especially energy consumption indoor environment thermal performance paper presents novel multi objective optimization model assist designers green building design pareto solution used obtain set optimal solutions building design optimization uses improved multi objective genetic algorithm nsga theoretical basis building design multi objective optimization model based simulation data energy consumption indoor thermal comfort study also used simulation based improved back propagation network optimized genetic algorithm characterize building behavior establishes network model rapidly predicting energy consumption indoor thermal comfort status residential buildings third building design multi objective optimization model established using network fitness function multi objective genetic algorithm nsga finally case study presented aid multi objective approach dozens potential designs revealed typical building design china wide range trade offs thermal comfort energy consumption elsevier rights reserved
good virtual learning space convey pertinent learning information visitors adequate time locations favor knowledge acquisition considering consolidation internet improvement interaction searching learning mechanisms propose generic architecture called cava create virtual learning spaces building cultural institution documents precisely proposal automatically create ontology based virtual learning environments thus impart relevant learning materials virtual propose use ontologies represent key concepts semantic relations user machine understandable format concepts together data extracted real documents stored digital storage format xml datasets relational databases etc displayed ontology based learning space enables visitors use available features tools learn specific domain according approach discussed desired virtual must specified rigorously domain specific language dsl designed implemented validate proposed architecture three case studies used instances cava architecture authors published elsevier
audio score framework consists two separate stages preprocessing alignment alignment commonly solved offline dynamic time warping dtw method find path distortion matrix minimum cost determine relation performance musical score times work propose parallel online dtw solution based client server architecture current version application implemented multi core architectures arm thus covering either powerful systems mobile devices extensive experimentation conducted validate software experiments also show framework allows achieve good score alignment within real time window using parallel computing techniques
fatal anaphylaxis humans rare unpredictable note trend provide allergic individuals care plans recommend immediate use epinephrine autoinjectors allergen ingestion suspected even absence allergic symptoms without supporting evidence base instructions use autoinjector device irrespective reaction severity especially symptoms actually absent likely add parental patient anxiety greater concern possibility epinephrine administered early treat initial mild symptoms progress severe anaphylaxis hard visualize scenario one epinephrine autoinjectors deployed mild symptoms yet reaction progresses severe reaction epinephrine available administration epinephrine needs available rescue treatment anaphylaxis potentially buying valuable minutes emergency medical services activated attend food allergic individuals carers need provided constructive strategies support merely told use pen authors published elsevier inc behalf american academy allergy asthma immunology open access article license
investigated effect progesterone treatment diabetes hyperglycemia induced pathological changes brain spinal cord sciatic nerve tissue male rats animals rendered hyperglycemic single dose streptozotocin stz treatment started hyperglycemia confirmed body weight blood glucose levels monitored week weeks rats underwent behavioral testing week euthanized histology assessed expression markers angiogenesis vascular endothelial growth factor vegf inflammation interleukin tissue injury cdb cox matrix metalloproteinase mmp brain spinal cord sciatic nerve also examined regenerative effect pathological changes intra epidermal nerve fibers ienf footpads diabetes hyperglycemia led body weight loss weeks treatment reduced loss week blood glucose levels significantly lower treated diabetic group compared vehicle compared sham treated groups diabetic vehicle group showed hyperactivity spontaneous locomotor activity test western blot data revealed upregulation vegf cdb cox mmp levels vehicle group treatment normalized expression levels ienf densities reduced vehicle group normalized treatment conclude reduce chronic pathological responses stz induced diabetes ibro published elsevier ltd rights reserved
spreading depolarization induced focal dendritic swelling beading early hallmark neuronal cytotoxic edema pyramidal neurons lack membrane bound aquaporins posing question water enters neurons spreading depolarization recently identified chloride coupled transport mechanisms least part participate dendritic beading yet transporter mediated ion water fluxes could paralleled water entry additional pathways large pore pannexin channels opened spreading depolarization using real time vivo two photon imaging mice pharmacological inhibition conditional genetic deletion pannexin showed pannexin channels required spreading depolarization induced focal dendritic swelling
ridge furrow rainwater harvesting rfrh system different ridge covering materials mulch collecting runoff water valuable technique enhancing seed filling rates maize productivity therefore field experiments conducted consecutive years large mobile rain proof shelter institute water saving agriculture semi arid areas china objectives study enhancing soil water storage promoting seed filling yield maize following two planting models traditional flat planting ridges covered different mulching material plastic film biodegradable film soil crust ridges two simulated rainfall levels rainfall results work revealed mulching material ridges distinct effect soil water storage depth soil middle furrows order approximate compared respectively average seed yield increased compared increased compared consecutive years respectively average wue significantly improved years compared respectively effect rfrh system maize seed filling significantly related simulated rainfall levels position seeds ear significantly promoted seed filling rates superior middle inferior seeds seed filling rates superior middle inferior seeds also significantly increased results suggested significantly increased sws seed filling process resulted higher grain yield might potential reducing maize productivity risk dry land farming system published elsevier
elevated forest mortality attributed climate change induced droughts prediction spatial mortality patterns remains challenging evaluated whether introducing plant hydraulics topographic convergence induced soil moisture variation land surface models lsm help explain spatial patterns mortality scheme predicting plant hydraulic safety loss soil moisture developed using field measurements plant physiology hydraulics model trees scheme upscaled populus tremuloides forests across colorado usa using lsm modeled topographymediated soil moisture respectively spatial patterns hydraulic safety loss compared aerial surveyed mortality incorporating hydraulic safety loss raised explanatory power mortality compared lsm modeled soil moisture topographic convergence mostly influential suppressing mortality low concave areas explaining additional variations mortality regions plant hydraulics integrated water stress along soil plant continuum closely tied plant physiological response drought addition well recognized topo climate influence due elevation aspect found evidence topographic convergence mediates tree mortality certain parts landscape low convergent likely influences plant available water
pegylated interferon alpha peg ifn shown induce hematologic molecular responses patients philadelphia negative myeloproliferative neoplasms mpns including polycythemia vera essential thrombocythemia describe series patients long standing mpns among peg ifn initiated developed anemia increased bone marrow reticulin fibrosis suggestive early transformation post pet post ppv myelofibrosis six patients treated peg ifn mean duration months range months five patients long standing three calreticulin calr positive one janus kinase jak positive one jak negative calr negative one long standing jak positive prior starting peg ifn first study report concurrent improvement anemia serial laboratory studies demonstrate increase serum ldh left shifted myeloid cells peripheral circulation approximately months followed gradual normalization findings splenomegaly also increased resolved among responding patients serial bone marrow biopsies available showed little change except improvement grade reticulin fibrosis two patients among patients early transformation pet ppv data support efficacy peg ifn improving hemoglobin levels reducing splenomegaly peripheral blood findings therefore considered evidence treatment failure within first year peg ifn therapy
objective paper explore structure kinematics kinetostatics balancing mechanism arm manipulates shredder capable performing maintenance task power transmission lines overall process organized following steps investigation structure arm review transmission lines motion calculation forces joints balancing mechanism masses springs analytical model mechanism presented allows design verification perspective strength materials highlights sensitivity model changes loads elements active forces engine
much research carried improve fatigue strength materials general leaf springs particular creating compressive residual stress field surface layers shot peening phenomenon surface roughness important considering contact metallic bodies effect shot flowrate surface roughness identified full scale laboratory testing ena spring steel leaf springs carried using electrohydraulic testing system show extent improvement fatigue life due shot peening double shot peening performed leaf springs effects surface roughness compressive residual stress field fretting fatigue noted surface roughness model accordance experimental results
background aims limited knowledge association composition intestinal microbiota clinical features irritable bowel syndrome ibs collected information fecal mucosa associated microbiota patients ibs evaluated whether associated symptoms methods collected fecal mucosal samples adult patients met rome iii criteria ibs secondary tertiary care outpatient clinics sweden well healthy subjects exploratory set comprised subjects ibs healthy subjects fecal samples mucosal biopsy samples collected analyzed ribosomal rna targeted pyrosequencing validation set comprised subjects ibs healthy subjects fecal samples mucosal samples collected analyzed subject measured exhaled oro anal transit time severity psychological gastrointestinal symptoms fecal methanogens measured quantitative polymerase chain reaction numerical ecology analyses machine learning procedure used analyze data results fecal microbiota showed covariation mucosal adherent microbiota using classic approaches found differences fecal microbiota abundance composition patients ibs healthy patients machine learning procedure computational statistical technique allowed reduce ribosomal rna data complexity microbial signature severe ibs consisting bacterial operational taxonomic units confirmed robustness intestinal microbial signature severe ibs validation set signature able discriminate patients severe symptoms patients mild moderate symptoms healthy subjects using intestinal microbiota signature found ibs symptom severity associated negatively microbial richness exhaled presence methanogens enterotypes enriched clostridiales prevotella species microbiota signature could explained differences diet use medications conclusions analyzing fecal mucosal microbiota patients ibs healthy individuals identified intestinal microbiota profile associated severity ibs symptoms
aims objectivesto identify meaningful types rewards consequences rewards expressed finnish registered nurses working primary private healthcare backgroundprevious studies found significant associations nurses rewards commitment job satisfaction furthermore appropriate rewards beneficial effects factors including workforce stability occupational satisfaction highly important times nurse shortages designa cross sectional qualitative interview study methodsdata collected via individual semi structured interviews registered nurses working finland primary private healthcare subjected qualitative content analysis resultssix meaningful types rewards identified registered nurses financial compensation benefits work life balance work content professional development recognition supportive leadership rewards encouraged respondents perform work correctly reinforced occupational satisfaction also caused feelings envy stress conclusionsit essential pay attention nurses preferences particular rewards reward management designing effective reward systems registered nurses sufficient provide financial rewards alone various kinds non financial rewards meaningful necessary relevance clinical practicewhen trying improve registered nurses commitment job satisfaction reward management important listen nurses opinions create reward system integrates financial non financial rewards fair perspective healthcare organisations offer registered nurses holistic reward system likely retain satisfied committed nurses time increasing nursing shortages
paper focuses manners filling gaps existing standards used tridimensional web technologies proposed way encoding huge data sets lossless png format use programmable rendering pipeline decoding png file allows reduce significantly file data time transmission via web time needed decode file
introduction known quality life qol patients surgically treated head neck cancer hnc significantly enhanced rehabilitation also known patients quit smoking aim assess smoking hampers rehabilitation related qol enhancement surgery method applying questionnaire eortc assessed qol smoking non smoking patients underwent surgical therapy hnc subsequent rehabilitation qol assessed surgery healing period months rehabilitation results qol enhancement nonsmokers significant almost aspects smoking patients reach level significance number scales results suggest smoking hamper rehabilitation directly rather prevents rehabilitation exerting beneficial effects effects conclusions smoking factor measurably acts efforts enhance qol surgically treated hnc patient therefore essential emphasis put smoking cessation right cancer diagnosis also reason
anzdata registry includes patients treated renal replacement therapy rrt throughout australia new zealand funding predominantly government sources together non government organization kidney health australia registry operations overseen executive committee steering committee wide representation data collected renal units throughout australia new zealand regular basis forwarded registry areas covered include demographic details primary renal disease type renal replacement therapy process measures variety outcomes data collection number themes work produced include production registry reports extensive range national regional data suite quality assurance reports key process indicator kpi reports data sets variety audit research purposes various types information anzdata registry used wide variety areas including health services planning safety quality programs clinical research projects
since substitution box box nonlinear component related confusion properties many block encryption algorithms necessity strong block encryption algorithms box vital component cryptography due effect security entire system therefore alternative box construction techniques proposed many researches study new box construction method based fractional order chaotic chen system presented order achieve goal numerical results chaotic chen system alpha obtained employing predictor corrector scheme besides simpler algorithm suggested construction box via time response chaotic chen system performance suggested box design compared box designs developed chaotic systems observed method provides stronger box design
cancer cells site numerous metabolic thermodynamic abnormalities focus review interactions canonical wnt beta catenin pathway peroxisome proliferator activated receptor gamma ppar gamma cancers implications energetic metabolic point view numerous tissues ppar gamma activation induces inhibition beta catenin pathway activation canonical wnt beta catenin pathway inactivates ppar gamma cancers ppar gamma downregulated wnt beta catenin pathway upregulated cancer cells upregulation wnt beta catenin signaling induces dramatic changes key metabolic enzymes modify thermodynamic behavior leads activation pyruvate dehydrogenase kinase pdk monocarboxylate lactate transporter consequently phosphorylation pdk inhibits pyruvate dehydrogenase complex pdh thus large part pyruvate converted acetyl coenzyme acetyl coa mitochondria part acetyl coa enter tricarboxylic acid cycle leads aerobic glycolysis spite availability oxygen phenomenon referred warburg effect cytoplasmic pyruvate converted lactate wnt beta catenin pathway induces transcription genes involved cell proliferation myc cyclin ultimately promotes nucleotide protein lipid synthesis necessary cell growth multiplication cancer activation pik akt pathway induces increase aerobic glycolysis moreover prostaglandin activating canonical wnt pathway plays also role cancer addition many cancer cells ppar gamma downregulated moreover ppar gamma contributes regulate key circadian genes cancers abnormalities regulation circadian rhythms crs observed crs dissipative structures play key role far equilibrium thermodynamics cancers metabolism thermodynamics crs intimately interrelated
since introduction late tumor necrosis factor tnf inhibitors proven effective treatment several inflammatory disorders use become increasingly common tumor necrosis factor blockade nonetheless associated increase risk infection intracellular granuloma forming pathogens histoplasma capsulatum performed query medical records cases disseminated histoplasmosis patients receiving tnf inhibitors years university hospitals case medical center cleveland ohio area moderate histoplasmosis endemicity total cases disseminated histoplasmosis identified receiving tnf inhibitor therapy time diagnosis five patients receiving infliximab receiving adalimumab patients generalized nonspecific presenting symptoms one complete response antifungal treatment cessation inciting tnf inhibitor five patients eventually resumed tnf inhibitor therapy year initial diagnosis disseminated histoplasmosis patient succumbed infection delayed diagnosis increasing use tnf inhibitors come increased awareness association opportunistic infections including disseminated histoplasmosis endemic fungi case series highlights importance early diagnosis infections achieve favorable outcome research need focus determining best long term treatment strategies managing patients resolution acute infection
torsion distribution cell paths two phase flow cell suspension porous medium important quantity chromatographic processes estimated cell tracking sequences three dimensional images suspension pumped medium images acquired situ time resolved microtomography using synchrotron radiation inline phase contrast modus contribution presents new method estimating path torsion discrete positions estimation based appropriate discretization differential geometric formula torsion space curve investigations performed alcoholic suspension silica gel particles pumped partially open polyurethane foam show shape inner surface foam considerable impact particle paths turns variance torsion slow particle moving close surface half order magnitude smaller fast particles underlines importance torsion filter efficiency lay description torsion estimation particle paths porous media observed situ time resolved microtomography chromatographic processes used separate cells specific type suspension mixture cells many chromatographic processes based filtering suspension inner surface filter medium modified way specific cells interact surface design filter important increasing efficiency chromatographic processes reason observe flow cell suspensions pore space filter based fast micro computer tomography torsion distribution distribution second curvature cell paths flow cell suspension pore space important quantity chromatographic processes estimated cell tracking sequences three dimensional images taken time resolved microtomography using synchrotron radiation low absorption contrast solid matter filter suspension flow cell suspension observed phase contrast experimental conditions image acquisition well technique torsion estimation described detail
testosterone deficiency adult age associated decrease libido energy hematocrit muscle mass bone mineral density well depression recently testosterone deficiency also associated various components metabolic syndrome turn associated five fold increase risk cardiovascular disease low testosterone levels associated increased insulin resistance increase fat mass low hdl cholesterol higher triglyceride levels hypertension testosterone replacement therapy patients testosterone deficiency type diabetes mellitus metabolic syndrome shown reductions insulin resistance total cholesterol ldl cholesterol triglycerides improvement glycemic control anthropometric parameters elsevier espana rights reserved
current state art literature indicates linear visual receptive fields gaussian formed based gaussian kernels biological visual systems paper employing hypotheses based anatomy physiology vertebrate biological vision propose neural circuitry possessing gaussian related visual receptive fields present plausible circuitry system matching characteristic properties ideal visual front end biological visual systems present condition circuit demonstrates linear behaviour model linear receptive fields observed biological experimental data objective study understand hardware circuitry various visual receptive fields biological visual system deduced model nonlinear neural network communicating spikes considered condition neural network behaves linearly discussed equivalent linear circuit proposed employs anatomical physiological properties early biological visual pathway derive visual receptive field profiles linear cells neurons isotropic separable non isotropic separable non separable velocity adapted gaussian receptive fields lgn striate cortex model presented theory transmission lines linear distributed electrical circuits employed two dimensional transmission grids model cell connectivities neural layer model presented leads formulation similar gaussian scale space theory transmission visual signals various layers neurons model therefore presents new insight convolution process gaussian kernels implemented vertebrate visual systems comparison numerical simulations model presented paper data analysis receptive field profiles recorded biological literature demonstrates complete agreement theoretical model experimental data model also good agreement numerical results gaussian scale space theory visual receptive fields
people express opinions things like products celebrities services using social media channels analysis textual contents sentiments gold mine marketing experts well research humanities thus automatic sentiment analysis popular area applied artificial intelligence chief objective paper investigate automatic sentiment analysis social media contents various text sources languages comparative findings investigation may give useful insights artificial intelligence researchers develop sentiment analyzers new textual source achieve describe supervised machine learning based systems perform sentiment analysis comparatively evaluate seven publicly available english hungarian databases contain text documents taken twitter product review sites discuss differences among text genres languages terms document target level sentiment analysis
study seeks identify suitable strategies promote effective learning construction management students boost instructors knowledge concerning choice appropriate strategies twenty two instructional strategies identified comprehensive literature review assessed based students perceptions determined questionnaire data returned valid questionnaires examined tested exploratory factor analysis efa structural equation model sem efa extracted five strategies web enhanced instructional strategy traditional learning instructional strategy activity based learning instructional strategy relational learning instructional strategy student centered learning instructional strategy results sem show student centered strategies strongest standardized regression path coefficient considered effective learning instructional strategies students based findings institution administrators channel available resources support strategies effective others similarly professors teachers adapt teaching styles strategies effective reconsider less effectiveness
execution plans constitute traditional interface dbms front ends back ends similar networks interconnected operators found also outside database systems tasks like adapting execution plans distributed heterogeneous runtime environments require plan transformation mechanism simple enough produce predictable results general enough express advanced communication schemes required instance skew resistant partitioning paper describe bobolangng language designed express execution plans well transformations based hierarchical models known many environments enhanced novel compile time mechanism component multiplication compared approaches based general graph rewriting plan transformation bobolangng iterative therefore consequences limitations process easier understand development distribution strategies experimenting distributed plans easier safer
objectives analyze feasibility efficacy novel system gamepad gaming experience parkinson disease biofeedback rehabilitation balance gait parkinson disease design randomized controlled trial setting clinical rehabilitation gym participants subjects randomized experimental physiotherapy without biofeedback groups interventions groups underwent sessions training balance gait experimental group performed tailored functional tasks using gamepad system based wearable inertial sensors provided users real time visual acoustic feedback movement exercises physiotherapy group underwent individually structured physiotherapy without feedback main outcome measures assessments performed blinded examiner preintervention postintervention month follow primary outcomes berg balance scale bbs walk test mwt secondary outcomes included instrumental stabilometric indexes tele healthcare satisfaction questionnaire results gamepad well accepted participants statistically significant group differences bbs scores suggested better balance performances experimental group compared physiotherapy without biofeedback group posttraining experimental group physiotherapy without biofeedback group mean points follow experimental group physiotherapy without biofeedback group mean points posttraining stabilometric indexes showed mediolateral body sway upright stance significantly reduced experimental group compared physiotherapy without biofeedback group experimental group physiotherapy without biofeedback group significant group differences found outcomes conclusions gamepad based training feasible superior physiotherapy without feedback improving bbs performance retaining month training mwt data comparable groups development system warranted allow autonomous use gamepad outside clinical settings enhance gait improvements increase transfer training effects real life contexts american congress rehabilitation medicine
well known high frequency excitation modify behavior systems respect slow motions goal study consideration effects rather general case analytical systems modulated sinusoidal excitation method direct separation motions proposed blekhman applied modified form explicit introduction small parameter equations slow motions obtained analysis depend structure original equations performed five basic effects corresponding different possible dependencies modulation amplitude position velocity slow time selected first time effects offer possibility designing high frequency control slow motions specified properties example high frequency excitation system nonlinear friction essentially increase effective damping results also significance system identification diagnostics analysis hydraulic valve given example application elsevier ltd rights reserved
wave implementation home automation broad category internet things iot date ability perform forensic investigations wave devices largely ignored however placement devices homes industrial facilities makes valuable assets investigation criminal adversarial actors wave devices consist sensors actuators connected internet via gateway therefore memory contents may contain sensor reports criminal activity indirectly provide evidence devices manipulated achieve physical cyber access paper provides details extracting programming flash eeprom memory common wave transceiver module found many wave devices specifically memory usage characterized several artifacts identified feasibility conducting firmware modification attack also explored results work identify several data structures including node protocol information table node adjacency table compiler coding language used firmware image also fingerprinted published elsevier ltd
voltage source converters vsc key power interfaces individual grids grids hybrid power system grid unbalanced grid currents distorted harmonic induced meanwhile oscillations active reactive power also increased may damage interfaces order ensure safety converters grid facility flexible control strategy proposed hybrid grid paper first current harmonic vsc theoretically analyzed unbalanced conditions furthermore methods separate positive negative sequence components grid voltages summed analyzed based theoretical analysis different protected control methods compared new control method flexibly control oscillations active reactive power introducing parameter proposed estimation maximum current phase discussed meanwhile relationship voltage ripple link parameter given finally validity advantages proposed method verified simulating experimental results
paper deals isomorphism constraint heterogeneous concept lattices concept lattices heterogeneous hedges essential point former approach encompasses full diversification data structures within formal context particular use different complete lattice diverse objects different complete lattice diverse attributes different poset diverse matrix fields latter framework heterogeneous hedges results reduction size corresponding concept lattice present properties constraint heterogeneous approach associated fixpoints hedges add remarks related studies elsevier rights reserved
comprehensive assessment lake water quality carried shahu lake northwest china provide valuable information present lake water quality decision making major ions general parameters bacteriological parameters organics trace metals monitored monthly considered monitored parameters compared quality criteria surface water china overall water quality assessment carried using entropy weighted water quality index ewqi based selected parameters lake water quality also assessed irrigation purpose results show lake water center dot facies high salinity cod geochemistry lake water regulated intense evaporation human activities major inorganic contaminants water samples polluted oil mainly attributed leaky motor tourist boats major organic pollutants lake water samples showing higher oil content permissible limit concentrations inorganic organic contaminants well trace metals well permissible limits present study indicates inorganic contamination lake water severe organic pollution overall lake water quality assessed ewqi poor poor tds dominant contributing factors lake water suitable irrigation terms alkalinity unsuitable irrigation salinity point view accelerating circulation replenishment lake water important way reducing contaminant concentrations study important providing comprehensive information lake water quality decision makers valuable reference international lake water researchers
interference alignment method improve capacity cell edge users thus attracts intense research interest focus extended multiple input multiple output mimo interference network method coordinated transmitter generates beamforming vectors align interference different transmitters confined subspace receiver using singular value decomposition svd relative magnitude coefficients transmitters calculate beamforming vectors received vectors however method difficult determine value relative magnitude coefficients system capacity improved necessary solve non linear function multivariable paper propose design method relative magnitude coefficients interference channels improve system capacity using brent method user mimo interference channel mimo ifc proposed method improve system capacity though system complexity increases due brent method requires multiple svd calculation calculate null space thus instead using svd introduce complexity reduction method calculate null space matrix furthermore extend proposed method applicable common systems base stations number transmit antennas simulation show proposed method achieves higher system capacity conventional one also show method calculates null space needs much lower complexity svd addition show proposed design method reduces degradation system capacity caused interference eliminated achieves fairness capacities among users increase number design coefficients
canine transmissible venereal tumour ctvt contagious venereal tumour dogs commonly observed dogs close contact one another stray wild dogs exhibit unrestrained sexual activity ctvt represents unique naturally transmissible contagious tumour mutated tumour cell causative agent perpetuates parasitic allograft host clinical history signalment cytological features often obvious establishing diagnosis though biopsy histological examination may needed atypical cases cases curable three intravenous injections vincristine sulphate weekly intervals role stray wild dogs makes disease difficult control necessitates sustained animal birth control stray dogs along prompt therapy affected dogs review captures manifold developments different areas embracing fascinating tumour including biology diagnosis therapeutic alternatives
protein misfolding aggregation implicated cause diseases humans alzheimer parkinson systemic amyloidosis retardation beta aggregation considered promising challenging strategy developing effective therapeutics alzheimer disease herein demonstrated effect vitamin inhibiting amyloid formation employing tht fluorescence assay circular dichroism ans fluorescence assay dynamic light scattering measurements transmission electron microscopy cell viability assay results demonstrate vitamin inhibits beta aggregation concentration dependent manner also provide protection amyloid induced cytotoxicity human neuronal cell line study points towards promising strategy combat beta aggregation may broader implication targeting neurological disorders whose distinct hallmark also amyloid formation elsevier rights reserved
introductionto investigate correlation microstructural parameters csf pressure macroscopic changes assessed diffusion tensor imaging dti patients idiopathic intracranial hypertension iih methodstwenty three patients iih well age sex body mass index bmi matched controls underwent high resolution imaging optic nerve sheaths ons pituitary gland ventricles dti data voxelwise permutation analysis performed whole brain roi analysis performed optic nerve optic radiation dti measurements correlated morphometric measurements csf opening pressure headache intensity reliability diagnostic performance dti parameters assessed using roc analysis resultsanalysis dti metrics revealed significant reduction fractional anisotropy optic nerve patients iih contrast systematic regional variations iih patients controls neither observed whole brain analysis optic radiation values optic nerve show significant correlations optic nerve sheath diameter correlation alterations values optic radiation whole brain show significant association morphometric alterations ons diameter hypophysis height well csf opening pressure headache intensity conclusionsthe results indicate iih associated microstructural changes optic nerve alterations may direct consequence chronically elevated intracranial pressure
background benign episodic unilateral mydriasis one cause anisocoria phenomenon thought related imbalance sympathetic parasympathetic nervous systems documented association migraines asymptomatic cases also reported challenge cases level investigation required exclude sinister causes nervous system dysfunction dynamic flight environment additional considerations need made varying light levels use night vision devices case report old woman deployment afghanistan flight nurse presented role one clinic right sided mydriasis patient denied headache history migraines dilated right pupil reactive light found exam symptoms exam findings resolved shortly initial presentation consulted ophthalmologist requested patient transfer review made diagnosis benign episodic unilateral mydriasis discussion variety causes anisocoria thorough history examination required avoid unnecessary investigations may locally available austere deployed military settings operational perspective decision needs made regarding maintenance flight status consideration needs given patient care capability treating flight nurse cases rapid resolution removal operational status reasonable clinician confident diagnosis
study introduces method alleviate non point source water pollution typically comprises organic inorganic pollutants synthesized hydrogel adsorbent customized simultaneous adsorption removal benzene heavy metals ion pollutants two functional groups successfully incorporated hydrogel system using solution polymerization chemical cross linking methods adsorbent golden brown insoluble water structural decomposition dry state started around degrees thermal properties hydrogel characterization adsorption mechanism described herein exploiting alkylating chemistry mono aromatic compounds hydrogel successfully adsorbed benzene onto heterogeneous surface strong nature adsorption relatively faster equilibrium time progressed according second order kinetic model however competitive heavy metal ions adsorption diffusion limited process adsorption capacity increased solution also ionic size amount metal ions electric charge type pollutants adsorbed onto pba hydrogel work therefore opens possibility synthesizing adsorbent systems customized simultaneous removal organic inorganic pollutants multi type polluted waters elsevier ltd rights reserved
objectives olfactory dysfunction described several neuropsychiatric disorders little research olfactory processing bipolar disorder methods assessed odor detection threshold sensitivity smell identification test scores along symptoms cognition social function dsm bipolar disorder patients control subjects results patient control groups similar demographic measures intelligence mean olfaction scores significantly differed social domains including adjustment function anxiety odor detection sensitivity showed significantly opposite correlations depressive manic mood domains bipolar disorder depressive symptoms related increased sensitivity ability detect odors lower concentration mania symptoms related decreased sensitivity odor detection increased sensitivity odor detection also predicted significantly better employment whereas less sensitivity associated social avoidance social fear conclusions diminished odor detection sensitivity predicted mania social avoidance whereas sensitive odor detection predicted depressive symptoms better employment functioning bipolar disorder patients odor acuity may illness state marker mood syndromes bipolar disorder alternatively differences odor acuity may identify heterogeneous subgroups within bipolar spectrum longitudinal assessments large sex stratified sample needed understand implications odor sensitivity patients bipolar disorder
future patients active role strengthening maintaining health telehealth empower motivate patients giving chance stay homes instead going hospital telehealth system deployed patient home hence influence everyday live therefore believe telehealth system shall adapt behavior burden patient resident use aim extended existing telehealth platform reason activities daily living smart home scenario extensions tested three casas datasets extensions two algorithms one understanding resident everyday habits one predicting resident next activity prediction algorithm correctly predicts casas datasets
progressing limits pollutant emissions oblige ship owners reduce environmental impact operations fuel cells may provide suitable solution since fuel efficient emit hazardous compounds various choices made regard type fuel cell system logistic fuel unclear best prospects maritime application overview fuel cell types fuel processing equipment presented maritime fuel cell application reviewed regard efficiency gravimetric volumetric density dynamic behaviour environmental impact safety economics shown low temperature fuel cells using liquefied hydrogen provide compact solution ships refuelling interval tens hours may result total system sizes five times larger high temperature fuel cells energy dense fuels vessels longer mission requirements expanding infrastructure liquefied natural gas development state natural gas fuelled fuel cell systems facilitate introduction gaseous fuels fuel cells ships fuel cell combined cycles hybridisation auxiliary electricity storage systems redundancy improvements identified topics study elsevier rights reserved
background aim study investigate effect marine polyunsaturated fatty acids pufa cardiac autonomic function vascular function patients psoriatic arthritis methods study conducted randomized double blind placebo controlled trial patients psoriatic arthritis supplemented pufa olive oil control daily weeks blood pressure heart rate heart rate variability hrv central blood pressure pulse wave velocity pwv fatty acid composition granulocytes determined baseline supplementation results baseline found significant difference mean normal intervals inverse heart rate vary beat beat comparing subjects highest lowest fish intake supplementation weeks trend towards increase decrease heart rate comparing pufa group control group however per protocol analysis showed significantly increased lowered heart rate pufa supplemented patients compared controls blood pressure pwv central blood pressure change supplementation pufa adjustment disease activity conventional cardiovascular risk factors change results conclusions marine pufa increased intervals patients psoriatic arthritis may suggest protective effect pufa cardiovascular disease population
objectives characterize types external causes pediatric injury related visits irvs emergency departments eds particular sports related injuries compare characteristics children irvs non irvs specifically differences irv rates race ethnicity health insurance methods stratified random sample survey eds national hospital ambulatory medical care survey nhamcs including irvs patients less years age national estimates pediatric irvs obtained using assigned patient visit weights nhamcs databases sudaan analyses measures association predictor variables patient health insurance characteristics whether child irv calculated using multivariate logistic regression analyses determine adjusted odds ratios confidence intervals results pediatric irvs accounted million visits annually common diagnoses irvs open wounds contusions sprains strains fractures dislocations leading external causes irvs sports related injuries accidental falls struck objects motor vehicle collisions children irvs differed presented non irvs many characteristics likely male older white race private insurance less likely asian hispanic ethnicity conclusions sports recreation leading external causes pediatric irvs eds united states different patterns irvs according gender age race ethnicity insurance identification specific patterns injury necessary design effective prevention strategies
soft parameter function penalized normalized maximum correntropy criterion spf nmcc algorithm proposed sparse system identification proposed spf nmcc algorithm derived basis normalized adaptive filter theory maximum correntropy criterion mcc algorithm zero attracting techniques soft parameter function incorporated cost function traditional normalized mcc nmcc algorithm exploit sparsity properties sparse signals proposed spf nmcc algorithm mathematically derived detail result proposed spf nmcc algorithm provide efficient zero attractor term effectively attract zero taps near zero coefficients zero hence speed convergence furthermore estimation behaviors obtained estimating sparse system sparse acoustic echo channel computer simulation results indicate proposed spf nmcc algorithm achieve better performance comparison mcc nmcc lms least mean square algorithms zero attraction forms terms convergence speed steady state performance
innovation management falls short solving urgent societal problems neglects power networks values constituent actors even though network business model innovation acknowledged innovation categories right problem solving potential remains unexplored article argue purposeful innovation requires considering shared values engaging innovation processes values understood subjective notions desirable values based innovation motivate development new networks business models address complex societal problems unsustainability current forms energy supply present theoretical framework facilitation methods values based network business model innovation applied exemplary workshop regional energy networks germany reflecting upon lessons learned theory practice conclude crucial starting points systemic sustainability innovations found values based networks business models
background pregnancy termination fetal abnormality tfa may profound psychological consequences involved evidence suggests women experience care influences psychological adjustment tfa greatly value compassionate healthcare caring women circumstances presents challenges health professionals may relate understanding women experience qualitative study examined health professionals perceptions women coping tfa assessed extent perceptions congruent women accounts methods fifteen semi structured interviews carried health professionals three hospitals england data analysed using thematic analysis compared women accounts coping processes identify similarities differences results health professionals perceptions women coping processes congruent women accounts identifying roles support acceptance problem solving avoidance another pregnancy meaning attribution key coping strategies health professionals regarded coping tfa unique grieving process cognisant women idiosyncrasies coping also considered role information providers essential helping women cope tfa findings also indicate health professionals lacked insight women long term coping processes potential positive growth following tfa consistent lack aftercare following tfa reported women conclusions health professionals perceptions women coping tfa closely matched women accounts suggesting high level understanding however lack insight women long term coping processes important clinical implications research suggests coping tfa long term process provision aftercare beneficial women together findings call research appropriate ways support women post tfa view developing psychological intervention better support women future
sex steroids positively affect brain function low levels sex steroids may associated worse cognitive function elderly men however previous studies reported contrary findings relationship testosterone level risk alzheimer disease elderly men objective study comprehensively assess relationship low testosterone level alzheimer disease risk elderly men using meta analysis prospective cohort studies assessing influence low testosterone level alzheimer disease risk elderly men considered eligible relative risks rrs confidence intervals pooled assess risk alzheimer disease elderly men low testosterone level seven prospective cohort studies total elderly men cases alzheimer disease included meta analysis moderate degree heterogeneity among included studies meta analysis using random effect model showed low plasma testosterone level significantly associated increased risk alzheimer disease elderly men random sensitivity analysis omitting one study turns showed obvious change pooled risk estimates pooled rrs statistically significant meta analysis supports low plasma testosterone level significantly associated increased risk alzheimer disease elderly men low testosterone level risk factor worse cognitive function elderly men
mortality rates liver transplant waiting list increasing shortage organs resulted higher utilization extended criteria donors ecds centers pushing limits acceptable transplantation donor quality appropriately represented continuum risk careful selection matching ecd grafts recipients may lead excellent outcomes although precise definition constitutes ecd liver review focuses frequently cited characteristics including donor age steatosis donation cardiac death donors increased risk disease transmission
family empowerment scale fes developed specifically assess empowerment families emotional disorders relevance custodial grandfamilies reflected difficulties grandchildren social emotional behavioral functioning wherein difficulties may explained via either reactions changes family structure responses newly formed family unit utilizing items derived item version fes represented differential levels empowerment family service system community indexed one attitudes knowledge behavior explored factor structure internal consistency construct convergent validity fes grandparent caregivers three hundred forty three age caucasian african american hispanic custodial grandmothers caring grandchildren ages years completed fes items various measures psychological well grandchild psychological difficulties emotional support parenting practices factor analysis revealed three factors differed slightly originally proposed fes subscales parental self efficacy self confidence service activism service knowledge factors internally consistent derived factor scores moderately interrelated speaking question convergent validity construct validity three factors evidenced meaningful patterns statistically significant correlations grandmothers psychological well grandchild psychological difficulties emotional support parenting practices factor scores independent grandmother age health education findings suggest newly identified fes factors valuable understanding empowerment among grandmother caregivers
objective describe medical services provided sexual assault patients emergency departments identify percentage hospitals always providing elements comprehensive medical care management cmcm methods cross sectional study conducted national sample hospitals item telephone survey assessed provision services sexual assault survivors accordance cmcm management included acute medical care comprising history physical examination acute long term rape crisis counseling sti testing prophylaxis emergency contraception counseling provision hiv testing prophylaxis primary outcome extent provision elements results overall emergency departments responded survey following components cmcm provided acute medical care rape crisis counseling sti management emergency contraception hiv management hospitals provided elements cmcm conclusion less one fifth hospitals provide comprehensive services sexual assault patients national program incorporating clinical guidelines checklists funding sexual assault forensic nurse examiner programs could improve standard care provided emergency departments primary point contact acute care sexual assault survivors international federation gynecology obstetrics published elsevier ireland ltd rights reserved
meta analysis average estimates multiple parameters treatment effect multiple outcomes across studies univariate meta analysis uvma considers parameter individually multivariate meta analysis mvma considers parameters jointly accounts correlation estimates performance mvma uvma extensively compared scenarios two parameters objective compare performance mvma uvma number parameters increases specifically show fixed effect meta analysis benefit using mvma substantially increase increases random effects meta analysis benefit mvma increase increases potential improvement modest presence high study variability actual improvement reduced need estimate increasingly large study covariance matrix iii little study variability loss efficiency due choosing mvma mvma increases increases demonstrate three features theory simulation meta analysis risk factors non hodgkin lymphoma
current study designed investigate micromeritic properties water absorption capacity stimuli ethanol saline responsive swelling deswelling switching controlled drug release polysaccharide glucuronoxylan isolated seeds quince water retention capacity quince hydrogel found admirable hydrogel also exhibited privileged swelling water basic buffers insignificant swelling acidic buffer swelling kinetics follows second order moreover deswells salt kci naci solutions ethanol sem swollen freeze dried revealed hollow channels average diameter furthermore sustained release levosulpiride tablet formulation drug release mechanism ascertained super case transport results signify smart material sustained release formulations elsevier rights reserved
paper analyzes causes rotor type parts vibration briefly describes present situation special balancing machine basis according current status domestic general high speed balancing machines balancing challenges high speed high power compact motorized spindle rotor analyzes balancing principle proposes balancing machines design solution ensure high accuracy reduce loading time complete dynamic balancing machine mechanical structure design
paper presents experimental study structural dynamics wake vortex modes lightly damped elastically mounted cylinder undergoing vortex induced vibration viv transverse direction cylinder neutrally buoyant mass ratio low damping coefficient zeta influence variation free stream velocity corresponding reduced velocity range reynolds number range structural dynamics cylinder examined conjunction detailed flow measurements around cylinder using digital particle image velocimetry piv cylinder stationary synchronization regime vibrating cylinder exhibits called soft synchronization phenomenon vortex shedding frequency synchronbus structural vibration frequency response frequency cylinder rather natural frequency system measured data cylinder undergoing viv fall within initial branch upper branches agree well published data free vibrating cylinders similar low mass damping transition initial upper branch characterized switch vortex formation mode classical mode newly discovered mode morse williamson journal fluid mechanics vol based forced vibrating cylinder distinction modes vivid terms length velocity scales shed vortices also reflected quantitative characterization near wake flow statistics including mean turbulence properties elsevier ltd rights reserved
wheel gymnastics gymnastic discipline history nearly years far epidemiological studies injuries wheel gymnastics retrospective study wheel gymnasts surveyed professionals competing first national league amateurs questionnaire injuries overuse syndromes found training leading time loss days incidence injuries per found wheel gymnastics professionals highly significant lower incidence amateurs injuries per common injuries wheel gymnastics found head spine ankle foot hip thigh knee injuries classified minor injuries caused time loss week month major injuries caused time loss longer month overuse syndromes per described wheel gymnastics high incidence low severity injuries compared gymnastic sports physicians aware common dangers overuse syndromes highly acrobatic gymnastic discipline iii
new universal current mode biquad filter using current differencing transconductance amplifier cdta proposed proposed configuration realize second order low pass high pass band pass band reject responses simultaneously circuit employs grounded capacitors ideal integrated circuit implementation offers low active passive sensitivities workability proposed configuration verified using spice simulation elsevier gmbh rights reserved
background ability reliably identify state activated repressed latent molecular process tumor patient individual whole genome gene expression profile obtained microarray rna sequencing rna seq promises important clinical utility unfortunately previous bioinformatics tools applicable large diverse panels patients limited single specific pathway process proliferation methods using panel whole genome gene expression profiles different studies built selected models predicting activation status compendium different biological processes using second independent validation dataset patients validated final list models included novo tool entitled absolute inference patient signatures aips also evaluated prognostic significance individual models predict outcome specific breast cancer subtypes results described development novo tool entitled aips identify activation status panel different biological processes individual breast cancer microarray rna seq profile without recourse broad cohort patients demonstrated aips stable compared previous tools inferred pathway state affected composition dataset also showed pathway states inferred aips agreement previous tools use far fewer genes determined several aips defined pathways prognostic across within molecularly clinically define subtypes two sided log rank test false discovery rate fdr interestingly models able distinguish patients luminal cancer luminal cancer fisher exact test fdr conclusion aips represents first tool would allow individual breast cancer patient obtain thorough knowledge molecular processes active tumor one individual gene expression profile
background traditional cine imaging cardiac functional assessment requires breath holding problematic situations free breathing techniques relied multiple averages real time imaging producing images spatially temporally blurred overcome methods developed acquire real time images multiple cardiac cycles subsequently motion corrected reformatted yield single image series displaying one cardiac cycle high temporal spatial resolution application algorithms required significant additional reconstruction time use distributed computing recently proposed way improve clinical workflow algorithms study deployed distributed computing version motion corrected binning reconstruction free breathing evaluation cardiac function methods twenty five patients volunteers underwent cardiovascular magnetic resonance cmr evaluation left ventricular end systolic volume esv end diastolic volume edv end diastolic mass measurements using motion corrected binning compared using breath held ssfp free breathing ssfp multiple averages performed two independent observers pearson correlation coefficients bland altman plots tested agreement across techniques concordance correlation coefficient bland altman analysis tested inter observer variability total scan plus reconstruction times tested significant differences using paired test results measured volumes mass obtained motion corrected binning averaged free breathing ssfp compared favorably obtained breath held ssfp edv esv mass inter observer variability good concordance correlation coefficients observers across acquisition types suggesting substantial agreement motion corrected binning averaged free breathing ssfp acquisition reconstruction times shorter breath held ssfp techniques average motion corrected binning required min less breath held ssfp imaging reduction acquisition reconstruction time conclusions motion corrected binning image reconstruction technique provides robust cardiac imaging used quantification compares favorably breath held ssfp well multiple average free breathing ssfp obtained fraction time using cloud based distributed computing reconstruction
church organization notion person charismatic discourse value pentecostal denominations deeply influence gender relations among church members turn gender relations influence ways charismatic discourse received concretised analysis explores complex process mutual transformations gender roles conversion meanings among pentecostal christians illegal settlement outskirts honiara solomon islands particular focus husband wife pentecostal households change way look undertake process charismatic renewal aim illustrate statement kwara man reveals meaning conversion long term process takes place relationally influence gendered values
modulation spontaneous excitability detrusor smooth muscle dsm upon pharmacological activation different populations channels investigated effects distinct channel openers spontaneous action potentials dsm guinea pig bladder examined using intracellular microelectrode techniques large conductance activated channel opener transiently increased action potential frequency prevented generation without hyperpolarizing membrane manner sensitive iberiotoxin ibtx higher concentration hyperpolarized membrane abolished action potential firing ska small conductance activated channel openers dramatically increased duration hyperpolarization abolished action potential firing apamin sensitive manner flupirtine channel opener inhibited action potential firing without hyperpolarizing membrane manner sensitive channel blocker brl beta adrenceptor agonist rolipram phosphodiesterase inhibitor also inhibited action potential firing higher concentration rolipram hyperpolarized dsm abolished action potentials ibtx prevented rolipram induced blockade action potentials hyperpolarization channels appear predominantly contribute stabilization dsm excitability spare channels could pharmacologically activated suppress dsm excitability channels appear involved cyclic amp induced inhibition action potentials membrane hyperpolarization elsevier rights reserved
advances medical treatment gastric ulcer duodenal ulcer lead increase number cases surgical interventions implied resection vagotomy classic laparoscopic approach required perforated diagnosis responsible high percentage deaths case excluded conservative treatment proton pump inhibitors eradication infection helicobacter pylori study presents observations treatment postoperative group elderly patients years associated chronic diseases studied group includes patients hospitalized department surgery pantelimon loan coltea hospitals emergency presentations duodenal ulcer relapse perforated cases perforated aged years mainly males cases duodenal ulcer recurrence first aggressive manifestation recurrent duodenal ulcer treatment instituted along terapeutical association regarding type diabetes hypertension heart failure cirrhosis situation treatment surgery considered national international guidelines consensus maastricht european concept management helicobacter pilory infection american digestive health foundation
paper proposes parametric optimization flux switching electrical machine customized wind turbine application typical operating range average low power wind energy sites statistics wind resources taken consideration machine design definition turbine power envelope copper iron losses three different machine designs evaluated important consideration taken design elimination gearbox requirements coupling turbine although developed approach makes machine somewhat voluminous overall performance highly improved direct drive flux switching electrical generator becomes competitive small scale wind turbines design methodology presented paper support widespread application small scale wind turbines rural systems farms villages paper concludes demonstrating cost effective distributed wind system approached design
african americans aas use cocaine southern region relatively high risk hiv need hiv testing among group residing rural areas may less favorable opinions common hiv testing sites could inhibit hiv testing examined rural urban variations acceptability multiple hiv testing sites private physician clinic local health department community health center community hiv fair hospital emergency department blood plasma donation center drug abuse treatment facility mobile van community outreach worker results partial proportional odds logistic regression analyses indicate rural use cocaine lower odds viewing local health departments physician offices drug use treatment centers acceptable relative urban counterparts findings implications targeting hiv testing toward aas use cocaine particularly residing rural south
backgroundthere previous studies adequacy combined evaluation possible abusive head trauma cases frontline medical personnel hospital based child protection teams child protective services local districts japan methodswe conducted questionnaire survey hospitalized patients months old diagnosis intracranial hemorrhage ich january december eleven large scale general hospitals yokohama japan surveyed provide centralized inpatient care moderately severely ill children resultsa total ich patients listed eight hospitals median patient age months younger months common diagnosis computed tomography subdural hematoma total cases occurred inside home injury scene unknown six cases reviewed cases viewpoint evaluation concern suspected child abuse three patients examined inflicted skin lesions skeletal surveys funduscopy conducted respectively thirteen cases reported hospital based child protection teams reported regional child protective services conclusionthe sociomedical evaluation possible child abuse appears systematically inadequate yokohama
objectives enzyme catechol methyltransferase comt catalyses degradation dopamine norepinephrine posited participate pathophysiology bipolar disorder schizophrenia support notion rich evidence documented severity various schizophrenia symptoms moderated single nucleotide polymorphism comt gene featuring valine val methionine met substitution results lower catalytic activity nevertheless specific relevance comt enzymatic activity pathophysiology schizophrenia dimensions remains elusive methods measured comt catalytic activity post mortem prefrontal cortices striata cerebella schizophrenia patients well non affected controls values correlated genotypes psychopathology scores last week life results direct correlation comt activity genotypes found however severity manic symptoms highly correlated comt activity striatum irrespective diagnostic group conclusions results suggest comt striatal activity genotype may serve biomarker manic symptoms future studies warranted confirm findings assess neurobiological links comt striatal activity manic symptoms
paper performance stability analysis lcl resonant converter analyzed presence source inductance researchers consider source inductance value assumed ideal reality negative impact systems stability output system resonant converter wide applications telecommunication aerospace radar power applications power supplies three topologies like lcc lcl lcl comparing three configurations lcl good stability region stability analysis done lyapunov stability analysis root locus analysis nyquist plot analysis open loop response closed loop response pid controller compared without source inductance concluded pid better response open loop system parameters like rise time settling time overshoot taken account result paper proves including source inductance rise time settling time overshoot becomes higher open loop system increased oscillations settling time using pid controller oscillations reduced settling time also reduced thus pid controller better response open loop system results simulated using matlab simulink software package
paper proposes generic model analyzing microwave power sensor calibration direct comparison transfer model derived using signal flow graph together nontouching loop rule analyses proposed model investigated several case studies commonly encountered provides theoretical basis practical applications finally realizations derived calibration equations practical cases also discussed
widespread adoption multi core architectures becoming important develop software ways takes advantage parallel architectures particularly entails shift programming paradigms towards fine grained thread parallel computing many parallel programming models introduced targeting intra task thread level parallelism however successful results traditional multi core real time scheduling focused sequential programming models example thread level parallelism properly captured concept interference key many schedulability analysis techniques thereby interference based analysis techniques directly applicable parallel programming models motivated extend notion interference capture thread level parallelism accurately leverage proposed notion parallelism aware interference derive efficient edf schedulability tests directly applicable parallel task models including dag models multi core platforms without knowing optimal schedule evaluation results indicate proposed analysis significantly advances state art global edf schedulability analysis parallel tasks particular identify proposed schedulability tests adaptive different degrees thread level parallelism scalable number processors resulting substantial improvement schedulability parallel tasks multi core platforms
paper new methodology design folded cascode recycling folded cascode rfc otas based noise reduction presented new formulation input referred flicker noise based characteristic operation regions significantly enhance noise performance achieved also technique leads larger gain gain bandwidth phase margin degeneration amplifiers simulated cmos technology simulation results confirm theoretical analyses proposed design methodology exhibits reduction input voltage noise rfc compared amplifier without increasing power consumption silicon area
paper explore incumbent firms fail identify new markets face disruptive technologies cross research disruptive innovation research managerial cognition focus role managerial beliefs customer needs directing search new markets product features show primary reason incumbents lose leadership inability recognize either rising social market customers use products fulfilling need friendship esteem market customers use products fulfilling need achievement apply emerging conceptual framework case smartphone industry ongoing rivalry among operating systems thus try advance disruptive innovation theory regard explanation anticipation technology competition outcomes elsevier inc rights reserved
wetlands commonly assessed ecological condition biological integrity using three tiered framework landscape scale assessment rapid assessment protocols intensive biological physiochemical measurements however increased inundation resulting accelerated sea level rise slr negatively impacting tidal marsh ecosystem functions northeast coastal wetlands yet relative vulnerability stressor incorporated condition assessments article assesses tools available measure coastal wetland vulnerability slr including measurements made part traditional rapid condition assessments vegetation communities soil strength field remote sensing based measurements elevation vdatum sea level affecting marshes model slamm model outputs vulnerability metric incorporates tools calibrated validated using recent rates marsh vegetation losses surrogate future vulnerability metric includes complementary measures elevation capital including percentage high low marsh vegetation spartina alterniflora height elevation measurements slamm outputs collectively explained variability recent rates marsh vegetation loss stepwise regression revealed three elements elevation vegetation measures slamm outputs explained significant largely unique components vulnerability slr greatest level overlap found slamm outputs elevation metrics soil strength varied predictably habitat zone contribute significantly vulnerability metric despite importance determining wetland elevation key tidal datums mean sea level mean high water caution vdatum found perform poorly back barrier estuaries factor makes difficult compare elevation capital among marshes differ tidal range poses accuracy problems broad scale modeling efforts require accurate tidal datums given pervasive pattern coastal wetland drowning occurring northeastern usa elsewhere advocate compilation regional data marsh habitats vulnerability slr crucial permits agencies target adaptation sites based vulnerability mixture habitats helps match sites appropriate interventions provides broader regional context site specific management actions without data adaptation actions may implemented action necessary disadvantage vulnerable sites opportunities successful adaptation missed
linear friction welding lfw relatively new process adopted aircraft engine manufacturers operationalizing new technologies produce better value components increasing fuel prices economical drives reduce emissions lfw key technology recent years aircraft engine manufacture commercial military market sectors joining blades discus blisks lfw ideal process solid state process gives reproducibility high quality bonds therefore improving performance fault detection isolation fdi model lfw machine developed order detect predict common machine faults purpose research investigation develop bespoke value improvement model vim lfw repetitive process identifying critical influencing factors whether human machine system achieving customer requirements successful fdi model implementation user uptake action research case study intervention implemented rolls royce site enabling combination hard systems fdi model soft systems vim model effectively utilized develop holistic model lfw vim outcomes research show vim approach used aid successful change management implementation complex system authors published elsevier selection peer review responsibility georgia institute technology georgia institute technology
democratic contexts strong aversion directive individualistic masculine expressions leadership come dominate study political leadership leadership antithetical consensus democracies parts continental europe antipathy leadership linguistic institutional well cultural dimensions political administrative socio cultural contexts countries provide little room heroic expressions leadership consequently alternative forms leadership associated vocabularies developed carry profound practical relevance remained underexplored based depth mixed methods study article presents dutch mayoralty insightful exemplary case called bridging bonding leadership provides clear illustration understandings democratic leadership deviate dominant paradigm leading consensus context brings unique practical challenges office holders analysis shows important leadership task democratic guardianship performed dutch mayors danger overlooked scholars political leadership consensus oriented leadership roles parts world reason recalibration leadership concept needed developing increased theoretical sensitivity towards non decisive process oriented aspects leadership phenomenon article specifies future study leadership part change advocated benefit adopting additional languages leadership
regulation various signalling ras mapk pik akt pathways augmented activity neurotrophic factors ntfs could prevent halt progress dopaminergic loss parkinson disease various vitro vivo experimental studies indicated anti parkinsonic potential asiatic acid pentacyclic triterpene obtained centella asiatica present study designed determine neurotrophic effect methyl phenyl tetrahydropyridine hydrochloride probenecid mptp neurotoxicity mice model treatment weeks significantly attenuated mptp induced motor abnormalities dopamine depletion diminished expressions ntfs tyrosine kinase receptors trkb revealed treatment significantly inhibited mptp induced phosphorylation mapk related proteins jnk erk moreover treatment increased phosphorylation pik akt gsk beta mtor suggesting activated pik akt mtor signalling pathway might cause neuroprotection offered present findings provided elaborate vivo evidences support neuroprotective effect dopaminergic neurons chronic parkinson disease mouse model potential developed possible new therapeutic target treat
rainwater harvesting rwh systems unique ability contribute stormwater management goals via mitigation runoff volumes peak flow rates additionally collecting storing runoff via rwh systems potentially provide water quality benefits due physical chemical processes occur within storage tank study quantified water quality improvement provided storing rooftop runoff via rwh systems four sites raleigh north carolina usa roof runoff extraction spigot samples analyzed total suspended solids tss nitrogen species total phosphorus roof concentrations significantly greater spigot concentrations constituents except tss indicating ability rwh systems significantly lower nutrient concentrations incoming roof runoff lack significant tss reduction likely attributable low irreducible concentrations tss roof runoff use additional filtration components prior extraction spigot could aid lowering spigot tss concentrations findings presented herein contend stormwater benefits associated rwh limited hydrologic mitigation also include reductions concentrations nitrogen phosphorus species thus recommended pollutant removal credit assigned systems used stormwater control measures
setting smoking reported associated tuberculosis effect sputum smear conversion remains matter discussion objective assess effects smoking smoking cessation treatment outcomes patients newly diagnosed iran design newly diagnosed smear positive patients included study smokers participated smoking cessation programme sputum smear status evaluated end month treatment smoking status evaluated end month differences smear conversion rates compared three groups non smokers smokers quitters results total smokers non smokers included smoking cessation assessed months smokers found quit cure rate end months precisely compatible conversion rate significantly higher among non smokers quitters months among persisting smokers respectively conclusion cure rates patients newly diagnosed pulmonary higher non smokers quitters months smokers smoking cessation advice included control programmes
versatile potentiostat based inexpensive shelf components reported platform shown capable performing simple electrochemistry experiments suitable undergraduate level teaching simple design construction enable easy customization accommodate broad array experimental designs equipment used calculate diffusion coefficient potassium ferricyanide aqueous solution obtained result good agreement literature although simple design low cost good performance device make competitive alternative teaching laboratories fields electronics electrochemistry developing teaching centers afford commercial device
rapid growth nanoscience technology implementation modern flat world industry engineering calling new curriculum engineering education change curriculum involves introduction new concepts examples scales new territories engineers territories previously acknowledged exclusive knowledge based playground scientists explorations broaden horizon basic understanding engineering mechanics concepts taught engineering disciplines essentials basic practical engineering understanding introductory level engineering mechanics taught courses statics dynamics strength materials paper addresses need importance reforms revisions engineering mechanics courses include experiences new territories engineering mechanics education expand beyond continuum macro based level include scales revision done introducing concepts multiscale engineering development new lesson modules perhaps including example problems micro nanoscales relying upon framework existing courses using existing physical intellectual resources array educational activities suggested provide opportunity undergraduate engineering students efforts facilitated visualization capabilities computer aided engineering drawing cadd techniques well analysis capabilities finite element model fem molecular dynamics procedures
varying chemical oxygen demand cod sulphate concentrations substrate used determine reaction kinetics mass balance organic matter sulphate transformation microbial fuel cell mfc mfc anodic chamber volume fed wastewater cod sulphate could harvest power coulombic efficiency respective cod sulphate removals sulphide concentration even inhibit anodic biochemical reactions due instantaneous abiotic oxidation sulphur high inlet sulphate experiments abiotic oxidation sulphide sulphur revealed maximum oxidation taking place anodic potential sulphate removal could achieved mfc inlet cod sulphate giving around day cod removal bioelectrochemical conversion sulphate facilitating sulphur recovery mfc makes interesting pollution abatement technique
work aims discriminate among different species genus cistus using seed parameters following scientific plant names included accepted plant list also intraspecific phenotypic differentiation creticus comparison three subspecies creticus subsp creticus subsp eriocephalus subsp corsicus well interpopulation variability among five creticus subsp eriocephalus populations evaluated seed mean weight morphocolorimetric quantitative variables describing shape size colour textural seed traits measured using image analysis techniques measured data analysed applying step wise linear discriminant analysis overall cross validated classification performance recorded species level regard creticus case study percentages correct discrimination achieved intraspecific interpopulation levels respectively classification model relevance colorimetric textural descriptive features highlighted well seed mean weight discriminant feature specific intraspecific level achievements proved ability image analysis system highly diagnostic systematic purposes confirm seeds genus cistus important diagnostic value
background plasma derived highly purified nanofiltered inhibitor concentrate berinert pnfc inh approved united states treating hereditary angioedema hae attacks many european countries attack treatment short term prophylaxis objective objective study describe safety usage patterns pnfc inh methods multicenter observational registry conducted united states european sites obtain prospective occurring enrollment retrospective occurring enrollment safety usage data subjects receiving pnfc inh reason results enrolled patients received doses pnfc inh hae attacks infusions prophylaxis infusions comprising safety population median dosages per infusion attack treatment prophylaxis approximately infusions administered outside health care setting adverse events aes reported retrospective data among prospective data subjects infusions aes reported subjects rate events infusion events considered related pnfc inh two thromboembolic events reported subjects thrombotic risk factors patient noted undergone viral testing suspected blood borne infection registry participation conclusions findings large international patient registry documented widespread implementation pnfc inh self administration outside health care setting consistent current hae guidelines real world data revealed pnfc inh usage variety reasons patients hae showed high level safety regardless administration setting reason use authors published elsevier inc behalf american academy allergy asthma immunology
deflection theory earth anchored suspension bridges fabrication camber presented considering tower effects large deflection effects main cables unstrained length method ulm keeps unstrained lengths cable frame elements constant iteration process extendedly applied nonlinear analyses suspension bridges live load combinations finally one cable without suspended girder two earth anchored suspension bridge models analytically numerically solved numerical results compared demonstrate accuracy validity deflection theory ulm particulars emphasized load effects suspension bridges live loads effectively evaluated applying semi linearized theory without relying nonlinear analyses
game based learning considered motivational tool accelerate active learning students learning environments usually follow computer assisted instruction concept offers adaptability student idea intelligent tutoring systems borrowed applied educational games teach introductory programming thus developed game based intelligent tutoring system gits form competitive board game board game revises classic table game snakes ladders improve web based problem solving skills learning computer programming moreover mini game tictac toe quiz applied gits update bayesian network used process decision making proposed system future work evaluate gits conducting experimental study using novices
objectivecurrent standard care united states uses two step screening diagnosis approach gestational diabetes mellitus gdm aimed assess impact interval screening diagnosis maternal perinatal outcomes materials methodsthis retrospective cohort study singleton pregnancies complicated gdm single tertiary center women divided three groups based interval screening diagnostic tests days maternal outcomes mode delivery white class agdm preeclampsia perinatal outcomes included preterm birth birth weight macrosomia hypoglycemia birth injury resultschart review revealed women diagnosis gdm included analysis women days women within days women days group maternal perinatal outcomes similar groups including risk cesarean delivery agdm preeclampsia macrosomia preterm birth hypoglycemia birth injury conclusionincreasing time interval screening diagnosis may negatively affect maternal perinatal outcomes pregnancies complicated gdm
background aims protective effect obesity death reported context various morbidities studied obesity paradox applied nursing home older residents according dementia status methods prospective data residents france cause mortality dependent measure subjects categorized according body mass index bmi underweight normal weight overweight obese dementia status obtained medical charts cox regressions performed results residents underweight normal weight overweight obese people died follow residents dementia mortality risk reduced almost half overweight obese people hrs respectively increased underweight compared normal weight residents moreover increase bmi decreased risk death underweight normal weight subjects dementia people without dementia mortality risk reduced overweight obese people hrs respectively compared normal weight unit increase bmi reduced risk death reduction underweight people conclusions study showed presence dementia amplifies obesity paradox old functionally limited residents therefore weight loss residents particularly people dementia considered extreme caution even obese people elsevier ltd european society clinical nutrition metabolism rights reserved
currently mankind afflicted diversified health issues allergies common yet little understood malady allergies outcome baffled immune system encompasses myriad allergens causes array health consequences ranging transient recurrent mild fatal indoor allergy serious hypersensitivity genetically predisposed people triggered ingestion inhalation mere contact allergens mite cockroaches one represented constituents arduous eliminate aeroallergens pose constant health challenges mostly manifested respiratory dermatological inflammations leading aggravations unrestrained recent times seen unprecedented endeavour understand conformation allergens immune manipulative ploys underlying causes pathogenesis importantly therapies yet large section vulnerable people ignorant innocuous looking immune irritants prevailing around continues suffer review aims expedite field concise informative account seminal findings past years particular emphasis leading frontiers like genome wide association studies gwas epitope mapping metabolomics etc drawbacks linked current approaches solutions overcome proposed seicap published elsevier espana rights reserved
high rates cholera epidemic mortality less developed countries challenge health facilities necessary equip epidemiological surveillance strengthen capacity epidemiological surveillance paper focuses remote sensing satellite data processing using data mining methods discover risk areas epidemic disease connecting environment climate health satellite data combined field data collected set periods order explain deduct causes epidemic evolution one period another relation environment existing technical algorithms processing satellite images mature efficient challenge today provide suitable means allowing best interpretation obtained results focus supervised classification algorithm process set satellite images area different periods novel research methodology describing pre treatment data mining post treatment proposed ensure suitable means transforming data generating information extracting knowledge methodology consists six phases acquisition information field epidemic satellite data acquisition selection transformation data data derived images remote sensing measurements discretization data data treatment interpretation results main contributions paper establish nature links environment epidemic highlight risky environments public awareness problem prevention policies absolutely necessary mitigation propagation emergence epidemic allow national governments local authorities public health officials effective management according risk areas case study concerns knowledge discovery databases related risk areas cholera epidemic mopti region mali west africa results generate data mining association rules indicate level niger river wintering periods societal factors impact variation cholera epidemic rate mopti town river level high rate contamination high elsevier ltd rights reserved
purpose reviewit proposed biodiversity loss leads reduced interaction environmental human microbiotas turn may lead immune dysfunction impaired tolerance mechanisms humans contact environmental biodiversity expected protect allergies however direct evidence linking contact biodiversity risk allergy lacking review consider latest research biodiversity hypothesis allergy recent findingsit becoming clear eat drink inhale touch contribute grand scheme host microbial crosstalk needed balanced healthy immune system develop maintain healthy recognition harmful harmless invasions microbes either communicate directly host immune cells affect host via metabolism even lead epigenetic modifications living environment plays key role process although especially early exposure diverse beneficial microbiota environment repeatedly found crucial studies immigrants demonstrate condition later life also decisive conclusionwe still lacking detailed understanding interaction natural environmental biodiversity health calls new innovative long term investigations outcomes utilized policy urban planning efforts promoting human interaction natural biodiversity supporting healthy lifestyle
growth huge privatised infertility care industry india attributed culture loaded stereotypically defined gender roles defines childlessness abnormal stigmatises infertility well lack infertility care public health system private infertility care market capitalises existing patriarchal normative cultural norms values proliferation assisted reproductive technologies arts one best examples response demands marketin case state art facilities women become mothers arts industry india including surrogacy attracted increasing cross border movement leading need analyse different stakeholders involvement well regulation industry
health communications baccalaureate nursing education increasingly impacted new technological tools article describes accelerated bachelor science nursing program incorporates infographic assignment graduate level online health information technology course students create colorful engaging infographics using words visuals communicate public health information assignment incorporates use data evidence provides students opportunity acquire new research technology skills gaining confidence creating innovating finished products may disseminated serving vehicles influence public health well
stress part parcel life stress management gaining importance day day traditional mantras reported effective safe methods hence traditional knowledge mantras practiced preserved propagated namah shivaya potent popular mantra heart vedas tantra present study aimed observe beneficial effects namah shivaya chanting stress management elderly women hypertension study conducted sattva cultural space research centre angamaly kerala elderly women aged years stage hypertension recruited present study obtaining written informed consent recording baseline values participants underwent practice sessions days supervision yoga teacher centre practice sessions participants chanted namah shivaya times using japamala beds morning days supervision yoga teacher participants instructed follow routine diet pattern life style medications assessment stress performed dass questionnaire blood pressure recorded using diamond digital sphygmomanometers bpdg cognitive functions assessed mmse scores observed significant decrease depression anxiety stress scores increase mmse scores followed chanting though blood pressure values decreased statistically significant study provides preliminary evidence beneficial effects namah shivaya chanting recommend detailed studies area understand role chanting namah shivaya stress management
affective instability conceptualized fluctuations mood time related ill health psychopathology study examined role affective instability daily pain outcomes patients chronic pain age years females using end day diary baseline phase patients completed self reported questionnaires pain severity pain duration disability depression anxiety subsequent diary phase patients filled electronic end day diary consecutive days assessing daily levels pain severity disability cognitive complaints negative affect positive affect affective instability operationalized mean square successive differences daily mood separately positive affect takes account size affective changes consecutive days results indicated instability positively associated daily disability beyond effects daily pain severity furthermore instability moderated relationship daily pain severity daily disability relationship daily pain severity daily cognitive complaints positive affect instability however showed unrelated outcomes current findings extend previous results reveal putative role affective instability pain related outcomes may yield important clinical implications indeed suggest targeting instability improving emotion regulation skills may strategy diminish disability cognitive complaints patients chronic pain
pulmonary alveolar proteinosis pap rare lung disease periodic acid schiff pas positive eosinophilic material accumulates alveoli lungs describe two cases young males presented dynpnoea weight loss hrct scan chest cases showed typical crazy paving pattern lung biopsies confirmed diagnosis pap showed remarkable symptomatic improvement therapeutic whole lung lavage
multidisciplinary rehabilitation beneficial effects health related quality life hrqol patients chronic rheumatic diseases however whether intervention benefits different age groups women men largely unknown investigate hrqol patients chronic rheumatic disease completion week multidisciplinary treatment special focus differences effect age gender groups hrqol measured mean scores domains compared week regimen month follow ups multivariable linear regression models using generalized estimating equations account repeated measurement employed weighting procedure account differential dropouts applied three hundred fifty six women men chronic rheumatic disease included short term improvements domains irrespective age gender effects persisted year psychological social energy domains women found lasting effects men however young men showed similar trends inpatient multidisciplinary rehabilitation improves short term hrqol patients younger women maintain beneficial effects year additional intervention considered elderly women men order sustain rehabilitation effects
paper presents development implementation evaluation online tool personalized mobile learning engineering graphics online tool designed support widespread mobile operating systems android ios windows mobile well interactive enable learning framework developed tool includes dropbox file storage application autocad interactive cad application various tools drawing study conducted sample undergraduate students students divided experimental group using developed online tool personalized mobile learning control group using traditional learning tools statistical analysis samples carried order study effectiveness online tool learning process results final test showed students experimental group successful students control group therefore use developed online tool personalized mobile learning engineering graphics considered improvement teaching engineering graphics
previous research provided qualitative evidence overlap number brain regions across subjective value network svn default mode network dmn order quantitatively assess overlap conducted series coordinate based meta analyses cbma results functional magnetic resonance imaging experiments task negative subjective value related activations human brain analyses first identified significant overlaps dissociations across activation foci related svn dmn second investigated whether overlapping subregions also showed similar patterns functional connectivity suggesting shared functional subnetwork find considerable overlap svn dmn subregions central ventromedial prefrontal cortex cvmpfc dorsal posterior cingulate cortex dpcc findings show similar patterns bidirectional functional connectivity cvmpfc dpcc present networks discuss ways understanding subjective value computed represented brain synthesized know dmn mind wandering self referential processing light findings
etiology pathogenesis parkinson disease complicated fully elucidated important association identified inflammation study investigated role nucleotide binding oligomerization domain leucine rich repeat pyrin domain containing nlrp inflammasome consisting nlrp caspase cytokines family lipopolysaccharide lps induced hydroxydopamine ohda induced rats microinjection different doses caspase inhibitor yvad cmk rat performed seven consecutive days rotational behavior number dopamine neurons substantia nigra pars compacta snc mrna protein expression levels nlrp inflammasome components measured days microinjection setup established results showed high mrna protein expression levels nlrp inflammasome components observed injected side lpsand ohda induced rats yvad cmk inhibited mrna protein expression nlrp inflammasome components lps ohda induced rats moreover number rotations significantly decreased number neurons snc improved data indicate nlrp inflammasome participates pathogenesis inhibiting downstream pathway nlrp caspase beta axis alleviate occurrence symptoms providing new basis prevention treatment
background objective data literature indicate relationship bone marrow microvessel density blood parameters angiogenesis aim study evaluate selected parameters angiogenesis vegf svegfr svegfr correlations white blood cells platelets red blood cells materials methods study included patients mean age years myeloproliferative neoplasms mpns essential thrombocythemia polycythemia vera primary myelofibrosis pmf serum vegf svegfr svegfr determined using elisa assay results observed significantly higher level vegf reduced concentrations svegfr svegfr whole group patients mpns compared controls detailed analysis confirmed significantly higher level vegf lower concentration svegfr subgroups mpns patients however svegfr concentrations significantly lower patients conclusions study showed increased level vegf may indicate intensity neoangiogenesis bone marrow decreased svegfr svegfr blood patients mpns may reflect consumption soluble receptors lithuanian university health sciences production hosting elsevier
number unaccompanied immigrant minors uims central america significantly increased nearly children salvador guatemala honduras crossed united states mexico border compared resources exist guide pediatric nurse practitioners pnps care uim multifactorial reasons behind migration state children health central america provide insight needs uims guidelines similar groups foreign born children refugees offer direction health care considerations uims article provides demographic information uims highlights unique challenging medical mental health issues facing uims discusses role pnp uim initial visit pnp serves opportunity build trust culturally competent trauma informed care provide preventive care assess unmet health needs screen mental health conditions
background exposure traffic related air pollution trap associated accelerated cognitive aging higher dementia risk human populations rodent brains respond trap activation astrocytes microglia increased inflammatory cytokines neurite atrophy role toll like receptor tlr suggested mouse tlr knockouts attenuated lung macrophage responses air pollution methods analyze mechanisms examined mixed glial cultures astrocytes microglia rna responses nanoscale particulate matter npm diameter well characterized nanoscale particulate matter subfraction trap collected local freeway morgan environ health perspect npm compared responses endotoxin lipopolysaccharide lps classic tlr ligand using affymetrix whole genome microarray rats expression patterns analyzed significance analysis microarrays sam fold change weighted gene expression network analysis wgcna identify modules shared responses npm lps finally examined tlr activation hippocampal tissue mice chronically exposed npm results sam wgcna analyses showed strong activation tlr kappa npm lps tlr sirna attenuated tnf alpha inflammatory responses npm vitro via myd dependent pathway vivo mice chronically exposed npm showed increased tlr myd tnf alpha tnfr rna decreased kappa traf rna tlr kappa responses hippocampus conclusions results show tlr activation integral brain inflammatory responses air pollution warrant study tlr accelerated cognitive aging air pollution
current study identified examined perceived self traits behavioral traits antecedents online empathic experiences prosocial behavior findings suggest perceived self traits self efficacy online relationship self disclosure strongly associated empathic experiences prosocial behavior findings behavioral trait interaction pattern individual indicate patterns individual networking produce mixed results regard association prosocial behavior bonding networking found positively predict prosocial behavior bridging networking showed negative association dependent measure identity discrepancy writing activities also found positively affect prosocial behavior overall finding study indicates perceived self traits tend display stronger explanatory power empathy prosocial behavior behavioral traits elsevier ltd rights reserved
article describe strategies programming techniques used porting multidisciplinary fluid thermal interaction procedure graphical processing units gpus discuss strategies selecting disciplines routines chosen use gpus rather cpus addition describe programming techniques including use compute unified device architecture cuda mixed language fortran cuda usage fortran memory mapping arrays gpu optimization solve equations using multi block structured grid finite volume numerical technique dual time step scheme used unsteady simulations numerical solver code targets cuda capable gpus produced nvidia use nvidia tesla gpus based fermi architecture compare resulting performance intel xeon cpus individual solver routines converted cuda typically run times faster gpu sufficiently dense computational grids used conjugate cylinder computational grid ran turbulent steady flow simulation using four increasingly dense computational grids densest computational grid divided blocks containing grid points total million grid points million grid points per domain block comparing performance eight gpus eight cpus obtain overall speedup using densest computational grid amounts gpu simulation running times faster running single cpu simulation
paper presents development guidance navigation control gnc system rotorcraft unmanned aerial vehicle uav air frame associated mathematical model explained vehicle electronics system based fpga development board peripherals gnc routines coded using hardware description language vhdl bits floating point arithmetic cordic algorithms inertial navigation system ins complemented gps implemented extended kalman filter included hybrid approach using pid fuzzy controllers proposed gnc system design system identification calibration done using test stand includes gimbal mechanism vehicle fixed labview application control parameters tuning data visualization purposes results derived flights tests using proposed system support approach fpga based gnc system uav tricopter
computer received applications various fields paper many new periodic wave solutions expressed jacobi elliptic functions mikhauilov novikov wang mnw hierarchy obtained using extended expansion method limit cases obtained jacobi elliptic function solutions degenerate solitary wave solutions trigonometric function solutions shown extended expansion method aid computerized symblic computation provide preferred mathematical tool finding new periodic wave solutions nonlinear partial differential equations pdes
purpose thyroid concentrates radioactive iodine sodium iodide symporter used treating hyperthyroidism thyroid cancer pancreas expresses nis radioactive iodine uptake may damage pancreatic beta cells predispose patients type diabetes aim study determine whether radioactive iodine associated glucose metabolism thyroidectomized rats methods forty male wistar rats divided four groups control thyroidectomized thyroidectomized treated thyroidectomized treated thyroxine end study serum fasting glucose insulin thyroid stimulating hormone free tetraiodothyronine measured intraperitoneal glucose tolerance test performed homeostasis model assessment insulin resistance calculated vitro experiments glucose stimulated insulin secretion pancreatic islets sodium iodide symporter mrna expression thyroid islets determined results compared control group free tetraiodothyronine lower thyroid stimulating hormone higher thyroidectomized groups respectively compared controls rats group glucose intolerance assessed using area curve intraperitoneal glucose tolerance test thyroxine replacement therapy restored value near normal fasting insulin homeostasis model assessment insulin resistance comparable groups however fasting glucose higher group vitro experiments glucose stimulated insulin secretion islets differ groups conclusion radioactive iodine therapy per effect glucose metabolism intensified thyroid hormone deficiency alterations glucose metabolism thyroidectomized rats thyroxine therapy restored glucose intolerance observed radioactive iodine treated thyroidectomized rats
paper evaluates existing policy frameworks mitigation diffuse water pollution agriculture dwpa england china reference conceptual model process policy transfer international lesson drawing possible constraints assesses whether china draw lessons improve current policy supra national national provisions member state comprehensively implemented agricultural environmental policy dwpa first analysed public policy challenge inform specification generic framework mitigation current policy frameworks mitigation dwpa england china evaluated potential improvement assessed number barriers lesson drawing regulation incentive payments schemes advice provision diagnosed barriers potentially least relation advice provision use promote voluntary action farmers given structure capabilities public agricultural extension system china also recognised key resource focus three policy approaches mitigate dwpa china recommended targeted regulation reference level large intensive livestock ultimately large commercial farms strategic use incentive payment schemes protect water resources dwpa iii orientation ethos modalities operation extension system informed international lesson drawing aim rebalancing farm productivity environmental protection elsevier ltd rights reserved
objectives analyse prevalence hypothyroidism rheumatoid arthritis patients elucidate correlation disease activity methods total patients enrolled study patients assessed fully clinically underwent routine laboratory investigation including thyroid function testing results hypothyroidism defined tsh level observed erythrocyte sedimentation rates esr found significantly elevated patients hypothyroidism compared without disease activity parameters das esr tender joint count vas scores also significantly higher former significant correlation serum tsh levels observed esr das esr conclusion thyroid function test included clinical evaluation patients
second order kdv equation introduced model describe wave propagation weakly nonlinear weakly dispersive system existence multi soliton solution raised open question paper develop procedures hirota method solving equation give rigorous proof sense symbolic computation equation admit single solitary wave solution chance obtaining exact multi soliton solution effort results illustrated hope trigger interests disciplines search new type multi soliton solutions elsevier ltd rights reserved
inter basin water transfer projects might cause complex hydro chemical biological variation receiving aquatic ecosystems whether machine learning models used predict changes phytoplankton community composition caused water transfer projects rarely studied present study used machine learning models predict total algal cell densities changes phytoplankton community composition miyun reservoir caused middle route south north water transfer project snwtp model performances four machine learning models including regression trees random forest support vector machine svm artificial neural network ann evaluated best model selected prediction results showed predictive accuracies pearson correlation coefficient models ann svm training step ann svm testing step therefore model best method estimating total algal cell densities furthermore predicted accuracies model dominant phytoplankton phyla cyanophyta chlorophyta bacillariophyta miyun reservoir ranged testing step predicted proportions water transfer different phytoplankton phyla ranged predicted dominant phyla water transfer season remained unchanged compared phytoplankton succession without water transfer results present study provide useful tool predicting changes phytoplankton community caused water transfer method transferrable locations via establishment models relevant data particular area findings help better understanding possible changes aquatic ecosystems influenced inter basin water transfer elsevier ltd rights reserved
accurate high resolution bathymetric data necessity wide range coastal oceanographic research topics active sensing methods ship based soundings light detection ranging lidar expensive time consuming solutions therefore significance satellite derived bathymetry sdb increased last ten years due availability multi constellation multi temporal multi resolution remote sensing data open data effective sdb algorithms proposed many authors ready use software module available geographical information system gis environment yet hence study implements geographically weighted regression gwr based sdb workflow geographic resources analysis support system grass gis module image bathymetry several case studies carried examine performance module multi constellation multi resolution satellite imageries different study areas results indicate strong correlation sdb reference depth instance case study puerto rico northeastern caribbean sea shown coefficient determination root mean square error rmse case study iwate japan shown rmse case study miyagi japan shown rmse reference depths acquired using lidar case study echo sounder case studies estimated sdb used one inputs australian national university geoscience australia anuga tsunami simulation model tsunami simulation results also show close agreement post tsunami survey data mage bathymetry module developed part study made available extension open source grass gis facilitate wide use future improvements
engaging mentalizing reflecting others thoughts beliefs feelings known facilitate later empathy prosocial behavior activation dorsomedial prefrontal dmpfc areas mentalizing shown predict extent prosocial behavior unclear however cognitive process drives effects simulation process mental states used proxy others self projection effortful enhancement process one perspective overridden fmri study examined effects mentalizing similar dissimilar others behavioral brain measures empathy prosocial behavior assess cognitive process mediates facilitative effects mentalizing participants mentalize two fictitious target persons one manipulated similar thoughts beliefs participant dissimilar mental states assessed participants behavioral neural responses empathy pain task prosocial behavior task similarity participant target person increased empathy affiliation ratings mentalizing dissimilar persons evoked increased activation ventrolateral prefrontal cortex extent inversely related bias towards similar person empathy responses two dmpfc regions also predictive later variations subsequent empathy prosocial behavior either predicting overall prosociality empathic concern lateral dmpfc predicting reduced empathic bias towards similar person lower response self related stressors pain matrix areas medial dmpfc pattern results suggests generating enhancing related representations overcoming one perspective rather enhanced recruitment self projection processes driving facilitative effects mentalizing later empathic prosocial responses elsevier rights reserved
background although clinical guidelines throughout world indicate clinicians take two bitewings detecting caries lesions primary molars children evidence recommendation essentially based cross sectional studies performed laboratory settings using convenience samples benefits impact performing radiographs diagnosis treatment decision caries lesions primary teeth mainly considering relevant outcomes patients evaluated yet thus aim randomized clinical trial evaluate impact performing radiographic examination adjunct visual inspection detecting making treatment decision regarding caries lesions primary teeth compared visual inspection performed alone consider different outcomes related children health welfare methods design reach objective children ages years sought dental treatment dental school randomly allocated two groups according diagnostic strategy used caries detection visual inspection performed alone visual inspection associated radiographic examination two trained calibrated examiners carry examinations elaborate treatment decision plan children treated followed years evaluations months inclusion children study children also return months reinforce preventive orientations primary outcome number dental surfaces need dental treatment follow secondary outcomes components primary outcome separately well proportion false positive results oral health related quality life cost efficacy cost adjusted life years number new lesions first permanent molars discussion working hypothesis radiographic examination would actually exert little influence patient centered outcomes visual inspection would enough diagnostic strategy caries detection primary teeth
long term plasticity well documented synapses glutamatergic principal cells cortex vitro vivo long term potentiation ltp depression ltd also reported glutamatergic connections hippocampal gabaergic interneurons expressing parvalbumin nitric oxide synthase nos brain slices plasticity cells tested vivo investigated synaptically evoked suprathreshold excitation identified hippocampal neurons area urethane anaesthetized rats neurons recorded extracellularly glass microelectrodes labelled neurobiotin anatomical analyses single shock electrical stimulation afferents contralateral elicited postsynaptic action potentials monosynaptic features showing short delay small jitter neurons commissural pathway theta burst stimulation tbs generated ltp synaptically evoked spike probability pyramidal cells bistratified cell two unidentified fast spiking interneurons contrary basket cells nos ivy cells exhibited either ltd ltp identified axo axonic cell failed show long term change response stimulation discharge cells explain whether ltp ltd generated fast spiking interneurons group correlation found plasticity local field potential oscillations components recorded immediately prior tbs results demonstrate activity induced long term plasticity synaptic excitation hippocampal nos interneurons vivo physiological pathological activity patterns vivo may generate similar plasticity interneurons
hypogonadism common throughout illness trajectory patients cancer two thirds male patients advanced cancer hypothalamic pituitary gonadal dysfunction low testosterone levels chronic inflammation comorbidities cachexia chemotherapy medications opioids megestrol acetate corticosteroids contribute primary secondary hypogonadism studies reported increased symptom burden diminished quality life poor prognosis associated low testosterone levels males cancer endocrine society published clinical practice guidelines replacing testosterone symptomatic patients chronic illness patients receiving opioids however role testosterone therapy specifically patients cancer addressed review explores potential benefits limitations testosterone replacement basis current evidence
viral hepatitis contributes significant morbidity mortality worldwide acute infection may self limiting unrecognised chronic infection utilisation guideline based approaches therapy contribute increasing rates cirrhosis hepatocellular carcinoma death aim review current evidence screening diagnosis treatment hepatitis evidence review sourced international australian guidelines high quality clinical trials medline searched using structured key word strategy retrieved articles reviewed methodically inform brief date synopsis hepatitis share recent developments viral hepatitis specifically new therapies hepatitis direct acting antiviral therapies safe well tolerated effective subsidies allow access australians strains hepatitis outline evidence underpinning efficacy safety treatment hepatitis clarifying nuances setting pregnancy immunosuppression provide simplified concept facilitate understanding five phases hepatitis practical real world setting hepatitis broad topic aspects viruses covered short review provided suggestions evidence based guidelines suitable supplement article
objective agitation aggression violence increased psychotic disorders additionally earlier age onset may associated aggressive behavior however relationship age onset agitatedaggressive syndrome measured positive negative syndrome scale schizophrenia excited component panss potential correlates first episode psychosis fep studied method study assessed association age onset agitated aggressive syndrome potential correlates prospective sample fep patients early onset adult onset followed months results twenty six patients conformed criteria early onset psychosis early age onset associated antisocial personality disorder phi history legal involvement phi higher rates lifetime substance use disorder sud phi early onset patients significantly higher panss scores course observation significant group differences emerged remaining panss subscores panss scores correlated positively antisocial personality disorder forensic history weeks months months months lifetime substance use disorder months months conclusions patientswith early onset psychosismay increased levels agitation aggressiveness likely antisocial personality disorder forensic history lifetime substance use disorder variables linked suicidality aggressiveness involuntary treatment elsevier rights reserved
minimal information sexual health provision mass gathering events aim describe use sexual health contraceptive sex worker sexual assault services london olympics analysed data five sources one contraceptive service provider reported increase attendance main games emergency contraception prescriptions rose main olympics compared week similar lower beginning end summer period health telephone advice line reported fall sexual health related calls main olympics increase subsequently london sexual assault referral centres reported sexual assaults olympics linked service sex workers reported started working sex industry moved london work olympics fifty eight per cent sex workers reported fewer clients increase police crack downs respectively results show change activity across services summer may associated olympics data guide services anticipating changes service activity planning staffing mass gathering events
real world uncommon face optimization problem three objectives problems called many objective optimization problems maops pose great challenges area evolutionary computation failure conventional pareto based multi objective evolutionary algorithms dealing maops motivates various new approaches however contrast rapid development algorithm design performance investigation comparison algorithms received little attention several test problem suites designed multi objective optimization still dominantly used many objective optimization paper carefully select modify test problems diverse properties construct benchmark test suite aiming promote research evolutionary many objective optimization emao via suggesting set test problems good representation various real world scenarios also open source software platform user friendly gui provided facilitate experimental execution data observation
background anecdotal clinical evidence transgender people use online world forums online video gaming purpose experiencing gender identity safe non threatening non alienating non stigmatizing non critical environment aims describe gaming behavior degree problematic gaming behavior associated factors problematic gaming comparatively large group transgender people accessing transgender health services methods every individual referred national transgender health service united kingdom month period invited complete series questionnaires measure gaming behavior interpersonal functioning severity autistic features anxiety depressive symptoms results total people agreed participate study describing current gamers gaming behavior transgender population attending transgender health services prevalent less presented clinical scores internet gaming disorder differences according gender problematic gaming behavior associated general interpersonal problems depression young age discussion conclusions transgender people engage problematic gaming behavior younger present high interpersonal problems depression affect successful transition view high levels gaming activity population games designed address psychological problems may well received transgender people
aim present study assess changes thyroid function thyroid autoimmunity tai throughout ovarian stimulation intracytoplasmic sperm injection icsi association changes icsi outcome flexible gonadotrophin releasing hormone gnrh antagonist protocol used women thyroid function tai assessed baseline five times days menstrual cycle day hcg administration day ovum pick day pregnancy test primary outcome measure change thyroid function throughout overall change recorded thyrotropin stimulating hormone tsh concentrations throughout women became pregnant increase tsh concentrations noted day pregnancy test compared day menstrual cycle respectively mean tai present women biochemical pregnancy negatively correlated changes tsh association noted regarding live birth rate present study provides evidence tsh concentrations could increase especially women become pregnant
lacking explicit knowledge someone sexual orientation gay people commonly assess likelihood another gay using gaydar term gaydar playful mix word gay radar suggesting one sense intuit perceive set characteristics another signal shared minority status commonly mentioned exact criteria gay person uses employing gaydar little discussed drawing methodologically series five focus groups self identified lesbians gay men study explores physical visual energetic conversational cues gay people consider employ trope gaydar specifically interview subjects often described gaydar triggered following elements physical presentation including mannerisms dress voice interactions especially eye contact presence absence certain conversational social norms intangibly kind energetic exchange
polylogarithms appear many diverse fields mathematics herein investigate relations amongst restricted class nielsen type essentially height one polylogarithms generic special arguments including sixth roots unity numerical computations suggest collected relations partially motivated previous study authors log sine integrals complete except case argument fundamental sixth root unity use applications results implemented accessible use symbolic computation facilitate numeric computation particular relations explicitly exhibited case low weights elsevier inc rights reserved
water scarcity current problem many urban areas mediterranean region due increasing water demand related population growth expansion urban industrialized areas climate change intensify pressure water resources rainwater harvesting rwh may effective alternative water supply solution face water scarcity recently become particularly important option arid semi arid areas mostly many benefits relative low costs present study aims analyse reliability rwh system installed supply water toilet flushing purpose reference single family house residential area sicily southern italy historical water consumption data analysed obtain flushing water demand pattern water balance simulation rainwater storage tank performed yield spillage algorithm used define tank release rule model performance evaluated using data different sites located throughout sicilian territory regional analysis provided results practical applications identification optimal rainwater tank size annual system reliability curves function mean annual precipitation uncertainty related regional model predictions also assessed results showed rwh systems provide environmental economic advantages sicily traditional water supply methods particular regional analysis identified areas application system would effective authors published elsevier ltd open access article license
life cycle assessment methodology along water footprint analysis used assess environmental impacts domestic rainwater harvesting system rwh france firstly relevance substituting drinking water rainwater private individual household studied secondly effect several parameters namely construction infrastructures building scale disinfection evaluated quantification environmental impacts performed using ecoinvent inventory data impact evaluation method water footprint assessed water stress indicator wsi environmental standpoint rwh system slightly higher impact system consumption electricity pumping generates strongest impact analysis wsi showed rwh system relieve stress water resources exists consideration infrastructures disinfection turns environmental impacts significantly higher impact categories setting rwh system bigger scale building scale bit less favoured rwh system household scale study aims pointing areas improvement need studied make rwh systems sustainable elsevier rights reserved
objective determine effectiveness orthodontic extrusion nonrestorable teeth prior implant placement improving alveolar bone gingival characteristics implant recipient sites materials methods electronic database searches following databases conducted help senior health sciences librarian medline pubmed embase scopus web science cinahl plus hand searches reference lists selected articles also conducted abstracts appeared fulfill initial selection criteria selected full article retrieval retrieved articles carefully evaluated specific selection criteria applied authors conducted selection processes independently differences resolved discussion analysis timing type magnitude forces applied sought results eighteen articles considered review selected articles case reports case series describing orthodontic extrusion periodontally hopeless maxillary anterior teeth results reported cases evaluated individually collectively regard various hard soft tissue implant site characteristics clinically significant gains alveolar bone gingival tissue reported cases resulting significant quantitative qualitative improvements implant sites conclusions based available literature orthodontic extrusion nonrestorable teeth prior implant placement appears viable alternative conventional surgical augmentative procedures implant site development direct comparison method found therefore conclusion could made relative efficacy
mental illness substance use overrepresented within urban homeless populations paper compared substance use patterns homeless individuals diagnosed schizophrenia spectrum bipolar disorders using mini international neuropsychiatric interview sample subjects drawn vancouver canada participated home chez soi study homeless individuals identified respectively previous months greater proportion homeless reported greater use cocaine chi amphetamines chi opiates chi hallucinogens chi cannabinoids chi tranquilizers chi compared cocaine opiates significantly associated homeless chi present study illustrates relationship substance use vulnerable urban population homeless affected adverse psychosocial factors severe psychiatric conditions
brown rot caused fungi monilinia laxa aderhold ruhland honey fructicola winter honey fructigena aderhold ruhland serious fungal disease peaches fungal infection process begins fungal conidia germinate fruit surface produce germ tubes appressoria incidence brown rot increases fruit approaches maturity interaction fungal infection process peach maturity environmental conditions well understood accordingly objectives investigation investigate germ tube appressorial formation laxa fructicola exposed peach skin mature immature fruit various temperatures relative humidities rhs greatest number germ tubes found laxa fructicola incubated culture medium contained skin extract mature peaches contrast greatest number appressoria found laxa fructicola incubated culture medium contained skin extract immature peaches although fructicola produced number germ tubes appressoria degrees fructicola produced germ tubes appressoria temperatures higher degrees laxa produced germ tubes appressoria temperature except incubated culture medium contained skin extract immature peaches degrees degrees laxa conidia germinated better fructicola conidia low temperatures germ tube appressorial formation monilinia spp influenced fruit postharvest handling number germ tubes formed laxa conidia significantly greater fructicola conidia incubated number increased days refrigeration number appressoria formed monilinia spp also increased consecutive days refrigeration negligible germination fructicola laxa conidia occurred concluded dissimilar abilities laxa fructicola germinate form appressoria low temperatures conferred competitive advantage laxa survive fruit postharvest refrigeration cold storage degrees elsevier rights reserved
paper describes new method automatically generate digital bas reliefs depth field effects general scenes previous methods bas relief generation take input form models however obtaining models real scenes objects often difficult inaccurate time consuming motivation developed method takes input set photographs quickly ubiquitously captured ordinary smartphone cameras depth map computed input photographs value range depth map compressed used base map representing overall shape bas relief however resulting base map contains little information details scene thus construct detail map using pixel values input image express details base detail maps blended generate new depth map reflects overall depth scene detail information map selectively blurred simulate depth field effects final depth map converted bas relief surface mesh experimental results show method generates realistic bas relief surface general scenes expensive manual processing
paper investigates application competitive intelligence techniques construction contractor selection process part overall construction contract management comprehensive ongoing applications employed variety industries provide valuable input broad strategic decisions construction industry lags behind adopting methodology use contract management important development light realization part major construction contractors diffuse nature information lack robust analysis create numerous uncertainties decision making processes findings paper show potential improve process assessing selecting contractors supporting unbiased auditable decision making process case study using contractor selection megaproject industrial sector presented along guidelines use implementation construction industry whole elsevier rights reserved
mesostructures responding external triggers temperature magnetic field potential used self acting sensors detectors switches key features strong well defined response external trigger present magnetic alignable bicelles embedded gelatin matrix generating magnetically switchable structures reversibly locked unlocked adjusting temperature show disk like aggregates orientated magnetic fields orientation preserved embedding gelatin resulting gel cubes show anisotropic transfer electromagnetic waves different spatial birefringence cycling melting point gelatin sets structure back isotropic state providing read thermal history stacking bicelles induced gelatin promotes magnetic aligning increased aggregation number stacks increases magnetic orientation energy
relational databases rdbs widely used back end information systems considering rdbs valuable knowledge interwoven stored data access represent share knowledge becomes important challenge topic maps tms emerge good solution problem however manual development tms difficult time consuming subjective task common guideline existing tms building approaches mainly consider meta information contained rdb without considering knowledge residing database content current state approaches require predefined configuration applying specific data transformation paper proposes automatic method construction based learning rules method considers background knowledge rdbs building process implemented applied representative set rdbs resulting tms validated syntactically using standard tool validated semantically inference information using formal query language addition analysis relational data input representation output conducted results found experiments encouraging put evidence soundness proposed method
cable stayed suspension bridge unconventional bridge type bridge typology based combination cable stayed suspension systems paper static behaviors cable stayed suspension bridge revealed viewpoint structural deformational characteristics different kinds live loads clearly illustrate characteristics simplified analytical method based simplified analytical solutions cable stayed bridges suspension bridges adopted derivations furthermore simplified material cost model based allowable stress method cable stayed suspension bridge also proposed researchers designers adopt preliminary design stage
evaluate trends patterns usage among children aged years netherlands period lists electronically archived paediatric scans requested radiology information systems ris dutch hospitals reported paediatric scans annually survey conducted data included patient identification birth date gender scan date body part scanned non participating hospitals years prior electronic archiving participating hospitals data imputed calendar year hospital type academic general beds general beds based scans among patients performed estimated annual numbers paediatric scans netherlands increased scans head neck last decade substantial increases per year observed general hospitals fewer beds among children aged years older estimated number paediatric scans tripled netherlands last two decades aeuro cent paediatric netherlands tripled last two decades aeuro cent number paediatric cts increased general hospitals aeuro cent paediatric cts continued increase among children aged years older
research parental monitoring children media use suggests parents reduce negative effects media exposure children although research rarely conducted elementary school children leaves open questions whether parents children better reporters participants children parents teachers parents children reported four aspects monitoring video games using limit setting amount limit setting content active mediation parents gave much higher estimates children monitoring moderated child age child sex parent marital status parent education parent income although parent child reported monitoring correlated rather poorly types almost equally good predictors children screen time media violence exposure teacher reports school performance differences child reports tended slightly better predictors demonstrating validity child reports parental monitoring
aim aim study determine nigerian parents views causes treatment childhood enuresis methods parents children aged years individually interviewed urban community nigeria using pretested questionnaire responses causes treatment enuresis grouped common themes results included respondents study mothers least one child enuresis spoken doctor enuresis thought due playing much drinking much fluid night respondents respectively two common treatment methods parents aware enuresis waking void urinating hot charcoal common methods parents actually employed included waking void punishing child nothing conclusion respondents believed playing much drinking eating much responsible childhood enuresis parents rarely discussed childhood enuresis doctors self help measures employed may harmful could constitute child abuse
contribution outlines scenario expected atmospheric impairments affect satellite radio link operating band derived present theoretical experimental knowledge paper discusses contributions signal fade due gases clouds scintillation rain emphasis also impact hydrometeor size distribution well depolarization electromagnetic waves main objective assess constraints face design satellite telecommunication system operating band copyright john wiley sons ltd
current study examined mediating effects teacher peer relationships parental abuse neglect child emotional behavioral problems total student surveys panel korean child youth panel study kcyps analyzed path analysis key findings study outlined firstly parental physical emotional abuse neglect significant effects children problems direct effect parental abuse emotional behavioral problems higher direct effect parental neglect emotional behavioral problems secondly teacher relationship partially mediated effects parental abuse neglect emotional behavioral problems thirdly peer relationship also partially mediated effects parental abuse neglect children emotional behavioral problems indirect effect parental neglect via teacher relationships peer relationships stronger indirect effect parental abuse study significant identified parental abuse neglect mediated teacher peer relationship thereby suggesting implication effective intervention children suffered abuse neglect terms teacher peer relationship understanding influence parental abuse neglect children problems discussed limitations recommendations future study suggested elsevier ltd rights reserved
one important research area autonomous mobile robotics create companions live ambience perform tasks help everyday life hand ambient intelligence ami seeks create network helpful intelligent devices paper describes approach development cooperation models eldercare robot teams using goal driven control components framework approach illustrated development assessment task allocation multi robot teams two cooperation models implemented team model based adaptive multi agent systems theory task responsibility agreed among team peers exchanging individual estimations degree difficulty priority achieve task hierarchical model robot manager asks estimations team members assigns task experimentation team cooperation assessment performed considering environmental changes well communications internal failures proposal simulated ami oriented elderly care center assist seniors need
present work monoclinic bismuth vanadate bivo nanostructures synthesized via simple hydrothermal method employed visible light driven antimicrobial photocatalytic activity morphology octahedral size bivo studied using transmission electron microscopy tem crystal structure bivo monoclinic scheelite structure confirmed high resolution tem hrtem ray diffraction xrd studies band gap bivo estimated kubellca munk function infinity using diffuse reflectance spectroscopy drs antimicrobial action bivo anticipated shake flask method mit dimethylthiazol diphenyltetrazolium bromide assay cytotoxicity sem analysis carried escherichia coli coli treatment nanostructure materials reveal mechanism underlying antimicrobial action antimicrobial activity studied function bivo concentration viz ppm bacterial growth decreased increase bivo concentration ppm ppm respectively photocatalytic activity rate kinetics bivo nanostructures studied function time methylene blue dye degradation one waste products textile industries responsible water pollution elsevier rights reserved
child abuse global problem parents histories childhood abuse increased risk abusing offspring objective systematic review provide clear overview existing literature randomized controlled trials evaluating effectiveness interventions prevent child abuse pubmed psychinfo web science sociological abstracts cinahl systematically searched expanded hand search review includes randomized controlled trials rcts interventions designed prevent abuse among mothers identified high risk eight studies identified three found statistically significant reductions abuse measure two found reductions incidents reported child protective services much written child abuse high risk families rcts performed home visitation significant evidence base reducing child abuse findings vary considerably also data low middle income countries limited authors published elsevier ltd
comparative measurements carbon polymer composite micro actuators based room temperature ionic liquid electrolyte carried situ vacuum using state art scanning electron microscope oxygen free atmosphere ambient pressure ambient environment fabricated micro actuators sustained actuation performance three environments revealing important implications regarding humidity dependence sem observations demonstrate high stroke actuation device sub millimeter length typical size range actuators desirable medical lab chip applications
congenital anomalies brain frequently correspond cranial base anomalies detailed description morphology individual variations developing cranial base clinical importance diagnosing anomalies development human cranial base studied using dissection computed tomography magnetic resonance imaging advantages disadvantages examined development normal human fetal cranial base using bone staining allows direct observation ossification centers precise three dimensional measurements observed alizarin red stained sphenoids basiocciputs normal formalin fixed human fetuses crown rump lengths crl defined landmarks measured sphenoids basiocciputs using fine caliper growth patterns ossifying bones obtained found similarities differences among growth patterns also observed individual variations ossification patterns particular single double ossification center patterns basisphenoid orbitosphenoid basisphenoid widths ratios widths total cranial base width significantly different two pattern groups whereas measurements ratios total cranial base differ groups measured cerebrum pons different sets human fetuses crls found close relationships development corresponding parts cranial base results contribute quantitative qualitative information growth patterns variations human fetal cranial base development
paper presents evaluation building integrated solar thermal shading bists system solar energy usage medium office building los angeles defined department energy doe used case study bists louvers mounted south east west facades building used harvest solar energy supply domestic hot water dhw space heating cooling solar thermal system modeled simulated trnsys solar fraction solar useful efficiency calculated recommended operation strategy proposed results indicated potentially annual domestic hot water load fully supplied bists system achieve recommended solar fraction either collector south facade collector east west facades required cooling load heating load met remaining collectors bists south facade primarily recommended provide space heating cooling combined heating cooling enables system take advantage solar energy energy savings auxiliary heating elsevier ltd rights reserved
managing excess nutrients remains major obstacle improving ecosystem service benefits urban waters inform ecologically based landscape nutrient management compared watershed inputs outputs retention nitrogen phosphorus seven subwatersheds mississippi river paul minnesota lawn fertilizer pet waste dominated inputs respectively underscoring importance household actions influencing urban watershed nutrient budgets watersheds retained net inputs versus net inputs watershed area weighted averages net inputs equal inputs minus biomass removal despite relatively low inputs contrast many nonurban watersheds exhibit high retention urban watersheds high street density enhanced transport rich materials landscapes stormwater high exports storm drainage networks yard waste resulted net losses watersheds comparisons stoichiometry net inputs versus storm drain exports implicated denitrification leaching groundwater likely fate retained thus urban watersheds exported high quantities via contrasting pathways exported primarily via stormwater runoff contributing surface water degradation whereas losses additionally contribute groundwater pollution consequently management management require different strategies management focusing reducing watershed inputs management also focusing reducing movement vegetated landscapes streets storm drains
past decade vast array nanomaterials created development nanotechnology increasing application nanomaterials various fields foods cosmetics medicines concern safety nanotoxicity therefore urgent need collect information biological effects nanomaterials exploit potential benefits design safer nanomaterials avoiding nanotoxicity result inhalation skin exposure particular immunomodulating effect nanomaterials one interesting aspects nanotoxicity however immunomodulating effects nanomaterials skin exposure adequately discussed compared effects inhalation exposure skin penetration nanomaterials thought extremely low normal conditions hand immunomodulatory effects nanomaterials via skin may cause severe problems people impaired skin barrier function nanomaterials could penetrate deep layers allergic damaged skin addition studies including shown nanomaterials could exhibit significant immunomodulating effects even penetrate skin review summarize current knowledge allergic responses induced nanomaterials upon skin exposure first discuss nanomaterial penetration intact impaired skin barrier next describe immunomodulating effects nanomaterials focusing sensitization potential nanomaterials effects exposure nanomaterials substances chemical sensitizers allergens onset allergy following skin exposure finally discuss potential mechanisms underlying immunomodulating effects nanomaterials describing involvement protein corona interaction nanomaterials biological components presenting recent data adjuvant effects well characterized particle adjuvant aluminum salt example immunomodulatory particulate
denitrification beds used reduce transport water soluble nitrate via subsurface drainage systems surface water recently non linearity water flow woodchips ascertained successfully design model denitrification beds optimum nitrate removal better understanding flow denitrification beds needed main objectives study characterize hydraulic properties old degraded woodchips provide better understanding factors affecting flow achieve goal conducted constant head column experiments using old woodchips excavated four year old denitrification bed near willmar minnesota usa izbash equation non darcy exponent ranged indicates post linear regime permeability coefficient degrees ranged forchheimer equation intrinsic permeability omega constant drainable porosity closely resembled situ properties found previous study forchheimer equation better izbash describing water flow old woodchips coefficients former provided stronger correlations drainable porosity strong correlation intrinsic permeability drainable porosity showed woodchip compaction important factor affecting water flow woodchips furthermore demonstrated importance temperature effects woodchip hydraulics conclusion hydraulic properties old woodchips characterized using non darcy equation help design efficient systems optimum nitrate removal elsevier rights reserved
purpose evaluate patient perceived impact delivery clinical pharmacy services including proactive follow program patient understanding satisfaction toxicity management methods patients received clinical pharmacy services initial chemotherapy treatment identified asked complete point survey second subsequent treatment services survey evaluated consist face face education first treatment proactive telephone follow days later results total respondents indicated time pharmacist first treatment worthwhile respondents reported interaction pharmacist increased understanding medication regimen respondents majority either satisfied satisfied time pharmacist spent pharmacist ability answer questions addition survey results indicate clinical pharmacy input provided pharmacist call back program valuable respondents indicating service worthwhile respondents stating pharmacist input helped manage side effects home conclusions survey results indicate patients value clinical pharmacy services ambulatory oncology chemotherapy setting services contribute improve patient understanding medication regimen high level patient satisfaction self management treatment related toxicities results support provision clinical pharmacy services proactive follow programs ambulatory chemotherapy units
functional neuroimaging studies revealed importance role cognitive psychological factors dysregulation brain gut axis functional gastrointestinal disorder patients although small number neuroimaging studies conducted functional gastrointestinal disorder patients despite fact neuroimaging technique requires high level knowledge technique still great deal potential application functional magnetic resonance imaging fmri technique functional gastrointestinal disorders provide novel methods diagnosing treating patients review basic knowledge technical practical issues fmri introduced clinicians
albumin bound paclitaxel colloidal nanoparticle abraxane fda approved anticancer formulation available market suspension currently used therapeutically treating cancers breast lung pancreas among others cdf novel new potent synthetic curcumin analogue widely used breast ovarian cancer aim study use biocompatible albumin well folate decorated albumin formulate colloidal nanoparticles encapsulating curcumin difluorinated cdf cdf demonstrated fold improvement stability remarkable anticancer potency compared natural derivative curcumin cdf showed marked inhibition cancer cell growth regulation multiple mirnas regulation phosphatase tensin homolog pten attenuation histone methyl transferase ezh however cdf highly hydrophobic photodegradable sparing aqueous solubility study formulated albumin
phosphatidylinositol kinase pik mammalian mechanistic target rapamycin mtor signalling pathway commonly dysregulated acute lymphoblastic leukaemia phase trial mtor inhibitor temsirolimus combination ukall induction chemotherapy conducted children adolescents second greater relapse initial temsirolimus dose level weeklyx doses subsequent patient cohorts received temsirolimus weeklyx doses secondary toxicity weeklyx doses sixteen patients enrolled evaluable toxicity dose limiting toxicity dlt occurred three dose levels included hypertriglyceridaemia mucositis ulceration hypertension reversible posterior leucoencephalopathy elevated gamma glutamyltransferase alkaline phosphatase sepsis addition temsirolimus ukall induction therapy resulted excessive toxicity tolerable children relapsed however regimen induced remission seven fifteen patients three patients minimal residual disease levels inhibition pik signalling detected patients treated dose levels temsirolimus inhibition early time point appear correlate clinical responses end induction therapy
increasing recognition gas constituents colon mainly metabolic products colonic microbiota associated pathogenesis colonic diseases modulated drugs diet therefore real time faecal gas profiler generate invaluable information study colonic disorders modulation unfortunately currently available intestinal gas profiling methods either unreliable cost ineffective rely line measurement equipment bulky expensive developed portable low cost vitro fecal fermentation system array gas pressure sensors system kept constant pressure using commercial release valve unit able measure vitro fecal gas production levels real time assess kinetics presence highly fermentable fiber feeding substrate headspace gas mixture altered mimic colon environment representative measurements intestinal gas production bacterial metabolic activities assessed simulated colon gas environment without added substrates suggests system potential practical research diagnostic instrument colonic disorders elsevier rights reserved
rationale menopause associated changes sex hormones affect immunity inflammation osteoporosis may impair lung function lung function decline previously investigated relation menopause objectives study whether lung function decline assessed fvc fev accelerated women undergo menopause methods population based longitudinal european community respiratory health survey provided serum samples spirometry questionnaire data respiratory reproductive health three study waves measured follicle stimulating hormone luteinizing hormone added information menstrual patterns determine menopausal status using latent class analysis associations lung function decline investigated using linear mixed effects models adjusting age height weight pack years current smoking age completed full time education spirometer including study center random effect measurements main results menopausal status associated accelerated lung function decline adjusted mean fvc decline increased confidence interval transitional women post menopausal women compared women menstruating regularly adjusted mean fev decline increased transitional women post menopausal women conclusions lung function declined rapidly among transitional post menopausal women particular fvc beyond expected age change clinicians aware respiratory health often deteriorates reproductive aging
many measurement applications required digital analog converters dac dacs use reconstruction anti imaging filter final step conversion process without filter generating continuous amplitude signal would possible paper presents new theoretical concept post dac continuous time filter proposed filter designed provide constant group delay desired frequency band maximally flat magnitude response moreover filter coefficients varied time order accelerate filter response results verifying effectiveness proposed approach presented compared performance traditional lowpass reconstruction filter
many hyperspectral image processing algorithms detection classification endmember extraction generally designed assumption spectral spatial correlation noise however previous studies shown presence nonnegligible correlation noise samples different spectral bands especially noises adjacent bands well known intrinsic dimension estimation algorithms give poor estimates presence correlated noise thus need tackle specific case spectrally correlated noise noise estimation show paper commonly employed hyperspectral noise estimation algorithm based regression residuals significantly affected spectrally correlated noise suggest modified approach proves robust noise correlation furthermore proposed method improves noise variance estimates comparison classic residual method even case uncorrelated noise simulation results show estimation error reduced times factor high spectral correlation noise proposed per pixel noise estimator requires estimate noise covariance matrix also propose method estimate noise covariance matrix simulation results demonstrate per pixel noise estimates obtained via use estimated noise statistics almost good obtained via use true statistics
paper blind crypto stego technique introduced using cryptography steganography concepts achieve double layered secured system proposed method consists two phases first data conversion dna using proposed generic bits binary coding rule leads lower cracking probability proved comparative studies dna amino acids playfair applied encrypt dna message resulting ambiguity second phase cipher text placed ambiguity using placement strategy shuffled hidden dna random positions generated using true real random number seed obtained atmospheric noise thereby achieving low cracking probability proposed technique blind preserved one achieves zero modification generated protein without extra data
modeling one important activities engineering activity article authors positions model classifications taken furthermore essential elements computer curriculum world importance modeling assumed last paragraph discusses structure modeling essential element mode action section structure competence unfolds modeling analysis taking support current definitions competence knowledge skills values self regulated learning processes assumed article development competence teaching software engineering must precede programming teach
introduction early origins chronic obstructive pulmonary disease recognized impulse oscillometry ios suitable assessment lung function also preschool children novel indices connected assessment small airway function however limited data exist sensitivity new indices detect lung function deficits young symptomatic children methods ios measurements healthy preschool children evaluated establish reference equations difference respiratory resistance relative difference area reactance curve thereafter ios results children late onset troublesome lung symptoms history early wheeze history bronchopulmonary dysplasia bpd compared healthy children results none patient groups differed healthy regarding respiratory resistance children history bpd differed healthy regarding respiratory reactance contrast scores significantly higher patient groups healthy children showing improved sensitivity compared conclusion superior conventional ios parameters distinguishing children current past lower respiratory tract symptoms healthy may prove valuable screening early lung function deficits wiley periodicals inc
middle east respiratory syndrome mers emerged saudi arabia caused zoonotically transmitted coronavirus cov cases reported date similar fatality rate lack autopsies mers cases hindered understanding mers cov pathogenesis small animal model develops progressive pulmonary manifestations infected mers cov would advance field mice restricted infection level dpp mers cov receptor generated mice humanized exons mouse dpp locus upon inoculation withmers cov human dpp knockin mice supported virus replication lungs developed illness serial passages lungs mice mouse adapted virus emerged mersma grew lungs times higher titers starting virus plaque purified mersma clone caused weight loss fatal infection virus antigen observed airway epithelia pneumocytes macrophages pathologic findings included diffuse alveolar damage pulmonary edema hyaline membrane formation associated accumulation activated inflammatory monocyte macrophages neutrophils lungs relative parental mers cov mersma viruses contained mutations including several within spike glycoprotein gene protein mutations sensitized viruses entry activating serine proteases conferred rapid entry kinetics recombinant mersma bearing mutant proteins virulent parental virus hdpp mice hdpp mouse mersma provide tools investigate disease causes develop new therapies
one biggest challenge world today find trade high energy demand mitigation greenhouse gas emissions researchers energy policy makers around world resorting renewable energy solution crisis special focus solar energy abundantly available source however requirement high upfront capital investment inhibiting factor behind seamless deployment solar energy technologies hence paramount importance increase techno commercial viability projects leveraging environmental factors specific project sites present work impact different kind aerosols characterize different distinct geographical regions performance photovoltaic cells investigated experimentally different irradiation levels complex set data generated experiment analysed indexed application combined shannon entropy data envelopment analysis dea quantify relative performance system different environmental conditions different tsp different concentration levels work comprehensive approach proposed decision makers enhance techno commercial viability projects elsevier ltd rights reserved
aimimplementation intervention result discrepancy planned delivered affecting outcomes recipients aim explore perspective hospital foodservice staff experiences delivering nutrition intervention barriers enablers implementation methodsa process evaluation pilot study undertaken using qualitative description purposive sample hospital foodservice supervisors foodservice assistants responsible delivering higher energy menu hospital patients participated focus groups semistructured interviews theoretical frameworks behaviour underpinned method content analysis elicited factors sub themes influencing foodservice staff capability opportunity motivation provide nutrition intervention thematic analysis two independent researchers explored factors themes related process intervention implementation resultsfive key themes sub themes explained factors effecting implementation nutrition intervention aspects foodservice environment patients resistance barriers implementation perceived sustainability teamwork problem solving leadership job satisfaction enablers opportunity optimise training feedback characteristics foodservice staff including knowledge beliefs perceptions diet health job role potential influence behaviours decision making conclusionsa number interacting factors influenced foodservice staff delivery higher energy menu planned addressing challenges time foodservice structure patients resistance gaps knowledge misconceptions among foodservice staff may enhance similar nutrition interventions future
ningbo city zhejiang province one largest port cities china achieved high economic development past decades port construction land reclamation urban development silt deposition ningbo coastal zone resulted extensive coastline change study spatio temporal change ningbo coastlines detected analysed using landsat time series images different sensors including multispectral scanner mss thematic mapper enhanced thematic mapper plus etm operational land imager oli fourteen individual scenes covering seven phases cloud free landsat images within required tidal range collected ziyuan image used extract reference coastline accuracy assessment normalised difference water index ndwi modified normalized difference water index mndwi applied discriminate surface water land features respectively screen digitising approach used refine extracted time series coastlines period six relevant indices length length change annual length change fractal dimension average net shoreline movement nsm average annual nsm calculated analyse explore spatio temporal change features ningbo coastlines results show length ningbo coastlines increased value increased coastline morphology changed sinuous straight average nsm increased average annual nsm reached year indicating advance coastlines towards sea high level spatio temporal change patterns also varied different areas hangzhou bay significant advancement along coastlines experienced since mainly urban construction land reclamation xiangshan bay forces nature played major role coastline dynamics whilst port construction urban construction island link projections moved coastlines towards sea coastline changes sanmen bay affected interaction nature human activities observations indicate forces nature human activities two important influential factors observed coastline change case coastline complexity variation considered responsible various coastline patterns change ningbo coast addition erosion accretion occurred turn forces nature human activities urban development agricultural exploitation
complete binary tree important network structure parallel distributed computing many nice properties often used embedded interconnection architectures locally twisted cube ltq important variant hypercube many better properties number edges vertices main results obtained paper complete binary tree cbtn rooted arbitrary vertex ltq embedded dilation congestion ltq exists one faulty node ltq dilation congestion become reconfiguring cbtn exist two faulty nodes ltq dilation congestion become reconfiguring cbtn faulty set ltq vertical bar vertical bar dilation congestion become reconfiguring cbtn certain constraints elsevier inc rights reserved
although research suggests misinformation provided witness could influential obtained sources research compared effect witness information non social forms misinformation better understand influence witnesses compared influence witness misinformation influence misinformation provided interviewer across two experiments using mori paradigm found evidence witness particularly influential relative another social source post event misinformation fact source misinformation delivered interviewer less likely correctly recalled source misinformation delivered witness evidence misinformation delivered witness interviewer stronger effect witnesses accuracy confidence misinformation obtained either source alone finally results suggest opportunity provide early individual memory account might protect effect subsequently encountered witness misinformation results important implications way criminal investigations conducted
ankle inversion ligamentous sprain one common sports injuries direct way investigate real injury incidents unethical impossible replicate test participants simulators including tilt platforms trapdoors fulcrum devices designed mimic ankle inversion movements laboratories inversion angle element considered early designs however ankle sprain composed inversion plantarflexion clinical observations inversion velocity another parameter increased reality simulation review summarised simulators aimed compare contrast features settings copyright asia pacific knee arthroscopy sports medicine society published elsevier singapore pte ltd
rhinocerebral mucormycosis rapidly fatal fungal infection affecting mostly uncontrolled diabetics multiple cranial nerves affected however palsy facial nerve rarely reported three uncontrolled diabetic patients presented outpatient department features rapidly progressive sinusitis unilateral facial nerve palsy evaluation proven mucormycosis patients uncontrolled diabetes facial nerve palsy underlying mucormycosis important early diagnosis treatment prudent favorable treatment outcome mucormycosis
paper describes mathematica based software studying nonlinear control systems software relies algebraic method called functions algebra advantage approach well known linear algebraic differential geometric methods applicable certain non smooth systems drawback computations complicated since approach manipulates directly functions related system equations differential one forms vector fields simplify linearize computations implemented basic operations functions algebra partial order equivalence summation multiplication also finding simplest representative equivalence class next group functions related control system involves binary relation operators computation certain sequences invariant vector functions basis system equations finally developed mathematica functions allowing solve following control problems case discrete time systems checking accessibility static state feedback linearization disturbance decoupling
thyroid dysfunction commonest endocrine disorder pregnancy apart diabetes thyroid hormones essential fetal brain development embryonic phase maternal thyroid dysfunction pregnancy may significant adverse maternal fetal outcomes preterm delivery preeclampsia miscarriage low birth weight review discuss effect thyroid disease pregnancy current evidence management different thyroid conditions pregnancy postpartum improve fetal neonatal outcomes special reference existing guidelines topic dissect critique compare overt hypothyroidism hyperthyroidism treated appropriately pregnancy aiming maintain euthyroidism subclinical hypothyroidism often pragmatically treated levothyroxine although definitively proven whether alters maternal fetal outcomes subclinical hyperthyroidism usually require treatment possibility non thyroidal illness gestational thyrotoxicosis considered autoimmune thyroid diseases tend improve pregnancy commonly flare emerge post partum period accordingly thyroid auto antibodies tend decrease pregnancy progression postpartum thyroiditis managed based clinical symptoms rather abnormal biochemical results authors published elsevier inc
background bipolar disorder commonly associated cognitive functional impairments even remission periods although growing number studies demonstrated benefits psychotherapy add pharmacological treatment effectiveness appears less compelling severe presentations disorder new interventions attempted improve cognitive functioning patients results mixed methods study consists clinical trial comparing new structured group intervention called cognitivebehavioral rehabilitation treatment usual tau bipolar patients new approach combination cognitive behavioral strategies cognitive remediation exercises consisting weekly group sessions min included study patients must diagnosed type aged years full partial remission least comprehensive neuropsychological battery followed mood social functioning quality life assessments occur three moments pre post intervention months later primary outcome study compare time weeks first full mood episode appears patients participated either group study secondary outcome include improvement cognitive functions discussion first controlled trial assessing validity effectiveness new cognitive behavioral rehabilitation intervention preventing new mood episodes improving cognitive functional impairments
hippocampus maintains capacity neurogenesis throughout life capacity reduced models adult onset hypothyroidism effects developmental thyroid hormone insufficiency neurogenesis adult hippocampus however examined graded degrees insufficiency induced pregnant rat dams administration ppm propylthiouracil ptu drinking water gestational day weaning body brain hippocampal weight reduced postnatal day hippocampal volume smaller ppm dose level second experiment examined adult hippocampal neurogenesis following developmental adult onset hypothyroidism two male offspring ppm exposed dams either maintained control water exposed ppm ptu create distinct treatment conditions control control control ptu ptu control ptu ptu based developmental adult exposures beginning day adult exposure ppm ptu bromodeoxyuridine brdu administered twice daily days one male treatment sacrificed days last brdu dose brains processed immunohistochemistry although volume changes seen hippocampus neonate ppm thinning granule cell layer emerged adulthood developmental insufficiency produced reduction newly born cells reducing brdu cells reduction days post brdu similar findings obtained using proliferative cell marker neuronal differentiations also altered fewer doublecortin dcx expressing cells higher proportion immature dcx phenotypes seen developmental adult insufficiency impaired capacity neurogenesis may contribute impairments synaptic plasticity cognitive deficits previously reported laboratory others following moderate degrees developmental insufficiency induced ptu model published elsevier
myeloproliferative neoplasms mpns clonal hematopoietic progenitor cell disorders characterized proliferation one hematopoietic lineages classical mpns include polycythemia vera essential thrombocythemia primary myelofibrosis pmf entities disorders characterized bone marrow morphology typical disease presence jakvf mutation marrow blood however jakvf account phenotypic heterogeneity mpns approximately half cases pmf show evidence molecular marker therefore search novel markers diseases necessary improve pathomorphological molecular diagnostics study aimed investigate changes expression patterns proteins stat signal transducers activators transcription erk extracellular signal regulated kinase bone marrow trephine specimens derived patients wild type mutant forms jak kinase furthermore changes stats erk gene expression levels patients also investigated results immunohistochemical immunoblotting qpcr studies revealed least four major unique features three types mpns include pronounced expression phosphostat protein patients jakvf mutation compared patients wild type jak kinase different expression pattern pstat nucleus cytoplasm megakaryocytes bone marrow cells iii approximately fold higher expression level stata gene comparison patients pmf approximately fold higher patients different intracellular expression patterns erk erk antigens allowed distinguish subtype mpn abnormalities expression patterns stats erk proteins genes provide novel molecular features mpns brings closer explaining pathogenesis mpns
paper concerned numerical solution unified first order hyperbolic formulation continuum mechanics recently proposed peshkov romenski denoted hpr model framework viscous stresses computed called distortion tensor one primary state variables proposed first order system important key feature hpr model ability describe time behavior inviscid viscous compressible newtonian non newtonian fluids heat conduction well behavior elastic visco plastic solids actually model treats viscous inviscid fluids generalized visco plastic solids achieved via stiff source term accounts strain relaxation evolution equations also heat conduction included via first order hyperbolic system thermal impulse heat flux computed governing pde system hyperbolic fully consistent first second principle thermodynamics also fundamentally different first order maxwell cattaneo type relaxation models based extended irreversible thermodynamics hpr model represents therefore novel unified description continuum mechanics applies time fluid mechanics solid mechanics paper direct connection hpr model classical hyperbolic parabolic navier stokes fourier theory established first time via formal asymptotic analysis stiff relaxation limit numerical point view governing partial differential equations challenging since form large nonlinear hyperbolic pde system includes stiff source terms non conservative products apply successful family one step ader weno finite volume ader discontinuous galerkin finite element schemes hpr model stiff relaxation limit compare numerical results exact numerical reference solutions obtained euler navier stokes equations numerical convergence results also provided show universality hpr model paper rounded application wave propagation elastic solids one needs switch strain relaxation source term governing pde system provide various examples showing purpose flow visualization distortion tensor aseems particularly useful authors published elsevier inc open access article license
based grid concept interactive hybrid online laboratory describe different fields applications different learning scenarios infrastructure guaranties reliable flexible well robust usage online lab using goldi students able design control algorithms different specification techniques control electro mechanical hardware models online lab additionally reconfigurable rapid prototyping platform goldi system used test taught topics given lectures field digital system design finally special demonstration platform ball labyrinth balance plate used give students better feeling possibilities limitations remote control observation via internet evaluate technologies critically
surface tension gamma dimethylamino propanol dmap dmap monoethanolamine mea dmap piperazine aqueous solutions measured using bzy surface tension meter temperature ranged mass fractions dmap mea respectively ranged equation proposed model surface tension calculated results agreed well experiments surface thermodynamics including surface enthalpy surface entropy determined concentration dependence analysed elsevier ltd
paper challenge notion green buildings achieve greater productivity buildings accredited green nearly two decades research produced apparent evidence indicates design green building enhance productivity occupants relationship building design productivity claimed achieved compliance internal environmental quality ieq criteria green rating tools paper reviews methods measuring productivity appropriateness metrics used measuring ieq office environments review supported results survey office building users identifies social factors significantly important environmental factors trying correlate productivity ieq also presents findings observations discretely carried user response green buildings findings demonstrate despite building compliance ieq criteria occupants still resort exceptional measures alter working environment bid achieve comfort work carried green buildings new zealand buildings rated based green star system adopted australian green star system roots breeam despite results research applicable many green rating systems paper concludes methods measuring productivity flawed ieq criteria building design unrepresentative occupants perceive environment lead architecture inherent characteristics good environmental design
purpose study explored utility california health interview survey chis compare health related outcomes among gay men lesbians heterosexuals reported legally recognized partnership methods regressed sexual identity marriage legally recognized partnership status seven different outcomes related health insurance coverage medical services access use general health wellbeing using chis data collected results respondents identified gay lesbian homosexual identified heterosexual percentage participants reported married legally partnered heterosexual women heterosexual men lesbians gay men legally partnered married gay lesbian respondents likely health insurance use healthcare counterparts partnerships trends statistically significant gay men legally recognized partnerships likely heterosexual counterparts report continuous health insurance coverage usual medical care source least one provider visit within past months found statistically significant poorer health status outcomes among lesbians legally recognized partnerships compared married heterosexual women conclusions lesbians legally recognized partnerships fare well married heterosexual women gay men legally recognized partnerships fared better married heterosexual men measures chis questionnaire structures limited sample analyses recommend chis researchers ask partnered status marriage sexual identity related questions bloc ensure robust representation analyses recommendations policy resolutions
eosinophils multifunctional granulocytes contribute initiation modulation inflammation role asthma parasitic infections long recognized growing evidence reveals role eosinophils autoimmune diseases review summarize function eosinophils inflammatory bowel diseases neuromyelitis optica bullous pemphigoid autoimmune myocarditis primary biliary cirrhosis eosinophilic granulomatosis polyangiitis autoimmune diseases clinical studies eosinophil targeted therapies experimental models contributed understanding regulation function eosinophils diseases examining role eosinophils autoimmune diseases different organs identify common pathogenic mechanisms include degranulation cytotoxic granule proteins induction antibody dependent cell mediated cytotoxicity release proteases degrading extracellular matrix immune modulation cytokines antigen presentation prothrombotic functions association eosinophilic diseases autoimmune diseases also examined showing possible increase autoimmune diseases patients eosinophilic esophagitis hypereosinophilic syndrome non allergic asthma finally summarize key future research needs
objectives aim study compare plasma biomarkers coagulation hiv infected individuals hiv uninfected controls assess impact disturbances coagulation neurocognitive functioning hiv design cross sectional study antiretroviral therapy treated virally suppressed hiv infected hiv uninfected older years age adults methods participants completed standardized neurobehavioral neuromedical assessments neurocognitive functioning evaluated using well validated comprehensive neuropsychological battery plasma biomarkers associated procoagulation fibrinogen selectin tissue factor von willebrand factor anticoagulation antithrombin protein thrombomodulin fibrinolysis dimer plasminogen activator inhibitor plasminogen collected multivariable linear regression used test interaction hiv coagulation neurocognitive functioning results participants male non hispanic white mean age years among hiv infected participants mean estimated duration hiv infection years median current cell count cells levels soluble biomarkers procoagulation anticoagulation fibrinolysis comparable hiv serostatus groups coagulation hiv interacting effect neurocognitive functioning greater coagulation imbalance associated poorer neurocognitive functioning among hiv infected participants moderating effect coagulation neurocognition driven procoagulant anticoagulant fibrinolytic biomarkers conclusions elevated levels procoagulants may exert particularly detrimental effect neurocognitive functioning among older hiv infected persons better understanding specific role coagulation cause hiv associated neurocognitive disorders may lead treatments aimed reducing coagulopathy thereby improving neurocognitive outcomes copyright wolters kluwer health inc rights reserved
nonoperative management fractures setting diffuse idiopathic skeletal hyperostosis dish ankylosing spondylitis often unsuccessful subaxial spine common site hyperextension fractures setting dish fractures upper cervical spine uncommon dish report knowledge first case describing successful nonoperative management type odontoid fracture patient dish discuss patient initial presentation physical examination imaging findings management year old male presented neck pain emergency department sustaining ground level fall computed tomography cervical spine demonstrated minimally displaced type odontoid fracture setting extensive dish immobilized hard cervical collar definitive management fracture collar discontinued months year follow stable fibrous nonunion fracture site tolerable neck pain flexion extension radiographs demonstrated stable alignment nonoperative management continued selected patients odontoid fractures setting dish role nonoperative management alongside close monitoring
educational landscape continues transform significantly way engages students interest improves learning processes example gradual use educational games seem exceptional means motivate engage students ways make learning challenging interesting however although educational games interesting tool could used education interesting challenge addressed identification ways students progress results measured examination way high demand accountability regarding measurement analysis enriched game based learning activities game based learning analytics gbla demand especially highlighted one difficult areas computer science computer programming education paper proposing framework guide incorporation learning analytics mechanisms computer programming education demonstrate process implementation framework educational massive multiplayer online role playing game developed domain
child wellbeing identified one three primary goals child welfare outcomes thus strong wellbeing assessment tools crucial monitoring child welfare success data wellbeing measures serve identify child needs inform case planning monitor change time evaluate intervention impact individual local state national levels paper examines goals strengths challenges four wellbeing measures currently used child welfare populations namely child adolescent functional assessment scale cafas child adolescent needs strengths assessment tool cans child behavior checklist related tools achenbach system empirically based assessment cbcl aseba treatment outcomes package top measure describe content practical attributes clinical applications evidence reliability validity explore implementation considerations provide recommendations system changes ensure optimal use instrument agencies encouraged carefully consider needs goals capacities implementation infrastructure inform selection tools aid successfully supporting monitoring child wellbeing time elsevier ltd rights reserved
according usgbc projects directory six leed certified projects registered projects egypt implies limited number leed projects egypt empirical studies conducted leed rating system performed markets egyptian one accordingly paper result longitudinal study performed three egyptian leed certified projects part master thesis research submitted cairo university first author second third author main supervisors objective study investigate implementation leed rating system credits egypt comparative analysis three egyptian leed certified projects results study included classification achieved targeted credits within egyptian market study may also contribute better understanding concept implementing leed green building rating system egypt may suggest recommendations future studies authors published elsevier
background yoga physical exercise used adjunctive intervention cognitive dysfunction schizophrenia controlled comparisons lacking aims single blind randomised controlled trial designed evaluate whether yoga training physical exercise training enhance cognitive functions based prior pilot study methods consenting clinically stable adult outpatients completed baseline assessments randomised treatment usual tau supervised yoga training tau supervised physical exercise training tau based pilot study primary outcome measure speed index cognitive domain attention penn computerised neurocognitive battery using mixed models contrasts cognitive functions baseline days end training months post training evaluated intention treat paradigm results speed index attention domain group showed greater improvement months follow effect size group accuracy index attention domain showed greater improvement tau alone month follow effect size several cognitive domains significant improvements observed compared tau alone effect sizes conclusions improved attention additional cognitive domains well past training period supporting prior reported beneficial effect speed index attention domain adjuncts benefit individuals
common core mathematics standards raised expectations schools students united states standards demand much deeper content knowledge teachers mathematics students given increasingly diverse student population today classrooms shortage qualified special education teachers computer assisted instruction may provide supplementary support conjunction core mathematics instruction meeting needs students different learning profiles purpose study explore potential effects please bring conceptual model based problem solving pgbm comps intelligent tutor program enhancing multiplicative problem solving skills students learning disabilities difficulties mathematics
work presents interactive self learning tool named technical drawing learning tool level tdlt lfor teaching manufacturing dimensioning engineering students tool designed students enrolled first year bachelor management mechanical engineering universities brescia udine consists simple interactive tool based video drawing animations aimed demonstrating connection real simple machining processes workpiece dimensions technical drawing tdlt currently available two versions standalone application windows android based operating systems set interactive pdf documents conceived first module package tools developed based learning levels proposed technical drawing evaluation gridtdeg preliminary evaluation tdlt effectiveness done involving management mechanical engineering students udine dimensioning exercises statistically considerations done obtained results confirmed validity tool self learning instrument average increase marks wiley periodicals inc comput appl eng educ view article online doi
cerebral artery aneurysm rupture usually associated significant subarachnoid hemorrhage however rare cases lack hemorrhage subarachnoid space subdural hemorrhage occur ruptured aneurysms isolated subdural hemorrhage often associated trauma case year old obese woman recently visited urgent care center elevated blood pressure found dead roughly month later complaining headaches received medication blood pressure visit medicolegal autopsy revealed cause death determined ruptured cerebral artery berry aneurysm right anterior cerebral artery contributing underlying cause hypertensive atherosclerotic cardiovascular disease significant subdural hemorrhage overlying right cerebrum subarachnoid hemorrhage present minimally patchy distribution virtual absence basilar hemorrhage additional unruptured aneurysm found left common carotid artery bifurcation cardiomegaly mild moderate atherosclerosis multiple vessels classic clinical presentation ruptured cerebral artery berry aneurysm involves sudden onset excruciating headache angiography provides conclusive image based antemortem evidence aneurysm scans used frequently emergency setting identify basilar subarachnoid hemorrhage common associated finding thus allowing diagnosis probable ruptured aneurysm depending circumstances given case presence subdural hemorrhage absence subarachnoid hemorrhage scan may suggest different underlying process trauma presented case serves remind clinicians ruptured berry aneurysms always produce significant subarachnoid hemorrhage elsevier ltd faculty forensic legal medicine rights reserved
article current energy consumption pakistan presented issue security electrical energy supply discussed power sector looked variety aspects demand supply gap diminishing energy sources energy security increasing energy costs furthermore status energy potential renewable sources energy discussed sustainable alternative addition roles different sectors promotion development renewable energy technologies discussed renewable energy future prospects encouraging pakistan total renewable energy potential enough meet total electricity demand country vast potential renewable sources energy could utilized overcome energy shortage utilized properly due lack policies infrastructure diversification existing energy resources exploration new sources important aspect considered order sustainable power development implementation country
objective relationship masticatory function cognitive impairment suggested still understudied investigated association chewing ability cognitive impairment among elderly living rural region methods total elderly individuals aged years rural city korea participated cross sectional study trained nurses conducted interviews assessed chewing ability using gum changed color based chewing performance cognitive impairment assessed using mini mental state examination dementia screening mmse korean vesrsion socio demographic characteristics activities daily living adl mini nutritional assessment mna also assessed using questionnaires potential confounders results mean age participants ranged years female participants low chewing ability significantly older dependent lower mna mmse scores elderly middle low chewing ability significantly higher risk cognitive impairment higher chewing ability conclusion findings suggest poor chewing ability associated cognitive impairment dementia elderly living rural area elsevier rights reserved
people often mimic others liked member ingroup cooperative relationship observer call interpersonal attitude effect study examines degree attitude effect mimicry automatic effortful process cognitive load load participants observed positive negative neutral others making emotional expressions electromyography measured corrugator supercilii knits brow zygomaticus major raises corners mouth activity load participants mimicked smiles positive individuals neutral negative individuals load trials participants mimic negative individuals mimic smiles neutral positive individuals participants enhanced smiles response smiles liked others without effort smiling neutral others smiles required greater cognitive resources
present study aimed examine relationships antisocial personality disorder apd symptoms adulthood retrospective reports childhood maltreatment parental bonding teasing controlling symptoms depression anxiety four hundred eleven non clinical participants males females aged years recruited australian university general public completed questionnaire package findings indicated significant associations childhood maltreatment parental bonding teasing depression anxiety levels apd symptomatology hierarchical regression analysis revealed physical abuse physical neglect teasing level father care made largest unique contributions prediction apd scores statistically controlling comorbid depression anxiety analysis variance revealed higher levels apd symptoms reported males younger participants research contributes importantly understanding factors influencing apd symptomatology clinical early intervention implications
associations depressive symptoms hypersomnia complex often bidirectional many disorders associated excessive sleepiness general population frequent mental health disorders particularly depression however mood disorder studies addressing hypersomnia assessed daytime sleepiness using single response neglecting critical clinically relevant information symptom severity duration nighttime sleep quality studies used objective tools polysomnography directly measure daytime nighttime sleep propensity depression normal mean sleep latency sleep duration hypersomnia mood disorders rather medical condition per subjective sleep complaint objective finding mood symptoms also frequently reported hypersomnia disorders central origin especially narcolepsy hypocretin deficiency could contributing factor condition interventional studies needed explore whether management sleep complaints improves mood symptoms hypersomnia disorders conversely whether management mood complaints improves sleep symptoms mood disorders
review presents broader approach implementation study runs homozygosity roh animal populations focusing identifying characterizing roh practical implications roh continuous homozygous segments common individuals populations ability homozygous segments give insight population genetic events makes useful tool provide information demographic evolution population time furthermore roh provide useful information genetic relatedness among individuals helping minimize inbreeding rate also helping expose deleterious variants genome frequency size distribution roh genome influenced factors natural artificial selection recombination linkage disequilibrium population structure mutation rate inbreeding level calculating inbreeding coefficient molecular information roh roh accurate estimating autozygosity detecting bothpast recent inbreeding effects estimates pedigree data ped better results roh suggest roh used infer information history inbreeding levels population absence genealogical information selection superior animals produced large phenotypic changes reshaped roh patterns various regions genome additionally selection increases homozygosity around target locus deleterious variants seen occur frequently roh regions studies involving roh increasingly common provide valuable information genome architecture disclose population genetic background revealing molecular changes populations time genome wide information crucial understanding antecedent genome architecture therefore maintaining diversity fitness endangered livestock breeds
craving considered one core features addiction defined urge conscious desire use drug elicited drug drug associated cues stressors craving plays major role relapse even prolonged periods abstinence well maintenance drug seeking non abstinent addicts circuitry craving includes medial parts prefrontal cortex ventral striatal zones ventral tegmental area ventral pallidum limbic regions interestingly cerebellum shows reciprocal loops many areas cerebellum linked traditionally motor functions increasing evidence indicates part brain also involved functions related cognition prediction learning memory moreover functional neuroimaging studies addressed study craving humans repeatedly demonstrate cerebellar activation craving elicited presentation drug related cues however role cerebellar activity craving episodes remains unknown therefore main goal review provide brief update craving studies traditional neural basis phenomenon discuss propose hypothesis function cerebellum craving episodes elsevier rights reserved
quantitative simulation forest fire spreading plays essential role designing quick risk management implementing effective suppression policies preferable modelling approach cellular automaton used simulate complex mechanisms fire spreading however traditional models comprehensive studies physical principles forest fires needed define local transition rules instead defining transition rules extreme learning machine elm applied study integrating elm traditional forest fire framework new cellular automaton modelling approach proposed performance validated using data collected five fires west united states results show elm performed well predicting cell igniting probability impact wind velocity fire spreading pattern effectively described proposed modelling approach furthermore validation actual fire behavior observations shows simulation performance acceptable cases better previously reported studies elsevier rights reserved
formal language theory plays computer science fundamental role allows among things development one cornerstones information technology programming languages define mandatory grammatical rules programmers need follow create tools enable humans interact machines despite significance formal language theory often taken granted even software developers regularly follow rules programming domain unless developer creating programming language data structure describing formal background existing one need dive deep formal languages grammar automaton theory need develop rules first understand theory formal languages limitations impose paper introduction fundamentals language theory classification restrictions representation ground rules set use worldwide known data structure format javascript object notation json formally define grammar rules automaton formal background allow transform theory bits developing algorithm analyze streams texts accepting rejecting comply predefined rules finally analyze outcomes implementation benefits limitations alternatives could followed
paper presents thyristor based tap changing transformer diode rectifier variable voltage high current applications back back thyristors connected series transformer taps primary side thyristors phase controlled continuous manner achieve variable voltage secondary side transformer leads variable voltage output three phase diode rectifier connected secondary side transformer passive filter added primary side achieve power factor improvement range output voltage scheme optimized determine optimum turns ratio transformer optimum reactive power rating passive filter design guidelines presented various values power factor along optimum turns ratios passive filter rating experimental system passive filter kva reactive developed verify system performance end comparison proposed topology state art topologies also presented
objective evaluate effects aquatic exercise therapy gait variability disability compared usual care people parkinson disease design single blind randomized controlled trial setting community based hydrotherapy pool participants individuals hoehn yahr stages iii interventions participants randomly assigned either aquatic exercise therapy group min twice week group received usual care main outcome measures primary outcome measure gait variability measured using motion capture system secondary outcomes quality life measured parkinson disease questionnaire freezing gait motor disability quantified unified parkinson disease rating scale feasibility evaluated measuring safety adverse events participant satisfaction results people aquatic therapy group usual care group showed similar small improvements gait variability aquatic therapy group showed greater improvements disability usual care group differences groups time identified freezing gait quality life aquatic therapy sessions safe enjoyable adverse events conclusions aquatic therapy appears feasible safe people early stages american congress rehabilitation medicine
water scarcity becoming increasingly critical issue modern society solar seawater desalination represents promising approach mitigating water shortage addition solar seawater desalination shows great potential mitigating energy crisis due high photo thermal conversion efficiency however increasing contamination seawater makes difficult generate clean water simple desalination processes work clean water generated newly designed bifunctional tio core shell nanoparticle film high photo thermal conversion efficiency capable photocatalysis solar evaporation seawater desalination bifunctional films tio core shell nanoparticles good stability prepared found formation core shell structures played key role promoting photo thermal conversion efficiency evaporation seawater photocatalytic function demonstrated herein could contribute purification polluted seawater furthermore film structure serve concentrate nps photo reaction well heat water evaporation improving photo reaction efficiency photo thermal conversion efficiency efficient approach solar seawater desalination combines evaporation photodegradation pollutants could help address dual issues water scarcity water pollution elsevier ltd rights reserved
remarkable progress understanding pathophysiology underlying mechanisms hereditary angioedema led development effective treatment disorder progress three separate areas catalyzed understanding hereditary angioedema first recognition hae type type result deficiency plasma level functional inhibitor observation led detailed understanding serping mutations responsible deficiency well molecular regulation inhibitor expression function second fundamental cause swelling enhanced contact system activation leading increased generation bradykinin substantial progress made defining parameters regulating bradykinin generation catabolism well receptors transduce biologic effects kinins third understanding tissue swelling hereditary angioedema primarily involves function endothelial cell adherens junctions knowledge driving increased attention role endothelial biology determining disease activity hereditary angioedema considerable progress made large gaps still remain knowledge important areas remain poorly understood include factors lead low plasma functional inhibitor levels triggers contact system activation hereditary angioedema role bradykinin receptor phenotypic variability hereditary angioedema extensively documented never understood mechanisms discussed chapter likely contribute variability future progress understanding mechanisms provide new means improve diagnosis treatment hereditary angioedema
article considers significance family context intergenerational drinking practices socialisation approaches drinking behaviours assume people carry forward actions ideals developed formative settings childhood particularly family community school article consider active interpretation time creative force challenge deterministic principles family socialisation consider parents use childhood experiences drinking necessarily blueprint act towards children accounts act able reverse childhood experiences account drinking across generations based analysis biographical interviews parents teenage children considers childhood experiences alcohol drinking influence parental strategies regulating children exposure alcohol
introduction liver plays central role thyroid hormone metabolism transport clearance normal function thyroid gland liver therefore necessary maintain normal thyroid hormone levels action data regarding thyroid function patients liver cirrhosis scarce variable consistent finding decreased free triiodothyronine level correlates severity liver disease proposed prognostic factor liver related complications aim study evaluate thyroid hormone values patients stable liver cirrhosis compare healthy controls without liver disease also assessed prevalence thyroid autoimmunity whether liver function tests correlated thyroid function material methods performed prospective case control study endocrinological setting twenty nine patients stable cirrhosis males females mean age years included case group healthy subjects males females mean age years control group excluded patients confounding factors known influence thyroid function levels serum thyroid stimulating hormone tsh free thyroxine anti tpo antibodies tpo measured thyroid hormone values compared groups biochemical indices liver function aspartate aminotransferase ast alanine aminotransferase alt alkaline phosphatase gamma glutamyl transpeptidase ggt inr total bilirubin albumin levels correlated thyroid function tests results levels significantly lower patients cirrhosis healthy subjects respectively tsh levels statistically significantly different two groups level tpo increased patients cirrhosis compared healthy controls correlated negatively child pugh score discussion results indicate compared healthy controls patients cirrhosis decreased levels comparable tsh levels may consistent findings limited acquired central hypothyroidism observed non thyroidal illness syndrome ntis levels correlated negatively child pugh score measure severity liver dysfunction find increased prevalence thyroid autoimmunity patients
astronomy era sky surveys mapping galaxy plethora photometric spectroscopic asteroseismic astrometric data allows characterize comprising stars detail quantify extent precise stellar observations reveal information properties star including properties unobserved even unobservable analyze diagnostic potential classical asteroseismic observations inferring stellar parameters age mass radius evolutionary tracks solar like oscillators lower main sequence perform rank correlation tests order determine capacity observable quantity probe structural components stars infer evolutionary histories also analyze principal components classic asteroseismic observables highlight degree redundancy present measured quantities demonstrate extent information model parameters extracted perform multiple regression using combinations observable quantities grid evolutionary simulations appraise predictive utility combination determining properties stars identify combinations useful provide limits type observable quantity reveal information star investigate accuracy targets upcoming tess plato missions characterized demonstrate combination observations gala plato allow tightly constrain stellar masses ages radii machine learning purposes galactic planetary studies
paper presents method extract flutter derivatives bridge decks based combination computational fluid dynamics cfd system simulations system identifications incompressible solver adopts arbitrary lagrangian eulerian ale formulation finite volume discretization space imposed sectional motion heaving pitching relies exponential time series input aerodynamic forces time histories acting section evaluated output system identifications carried fit coefficients inputs outputs arma models establish discrete time aerodynamic models system simulations established models performed obtain lift moment exerting sections sinusoidal displacement follows flutter derivatives identified present approaches applied hexagon thin plate real bridge deck results compared theodorsen closed form solution wind tunnel tests satisfactory agreements observed
satisfy demand multilayer films polarization detection polarized bidirectional reflectance distribution function multilayer films slightly rough substrate established basis first order vector perturbation theory polarization transfer matrix due function light scattering polarization properties studied multi factor impacts two typical targets monolayer anti reflection film multilayer high reflection films result shows monolayer anti reflection film observing positions great influence degree polarization left peak increased right decreased compared substrate target film target bare substrate distinguished degree polarization different observation angles multilayer high reflection films degree polarization significantly associated number optical thickness layers different wavelengths incident light scattering angles increase layer number degree polarization near mirror reflection area decreases reveals calculated results coincide experimental data validates correctness rationality model paper provides theoretical method polarization detection multilayer films target reflection stealth technology
background quince cydonia oblonga miller deciduous shrub belonging rosaceae family quince seed extract long used cosmetic ingredient moisturizing effect however little known whether quince seed extract therapeutic effects keratinocyte associated skin inflammation methods present study investigated effect topical application ethanol extract quince seeds qsete atopic dermatitis symptoms nga mice direct effect qsete keratinocytes evaluated using human keratinocyte cell line hacat results preliminary application qsete markedly reduced house dust mite allergen induced skin lesions expression thymus activation regulated chemokine tarc dorsal skin downregulated qsete directly suppressed expression production tarc hacat cells conclusions results suggest topical application qsete effective preventing onset ameliorating atopic symptoms keratinocyte associated skin inflammation suppressing tarc production keratinocytes
background well established childhood maltreatment risk factor various mental substance use disorders date however little research focused possible long term physical consequences diabetes chronic disease association postulated methods based data sample men women canadian community health survey mental health cchs study examines associations three types childhood physical abuse cpa childhood sexual abuse csa childhood exposure intimate partner violence ceipv diabetes adulthood multiple logistic regression models used examine associations diabetes controlling effects socio demographic characteristics risk factors type diabetes results controlling socio demographic characteristics diabetes significantly associated reports severe frequent cpa severe frequent csa dose response relationship observed occurrence csa cpa considered strongest association diabetes observed severe frequent csa cpa reported controlling type diabetes risk factors attenuated associations particularly cpa ceipv significantly associated diabetes adulthood conclusion cpa csa risk factors diabetes part associations cpa diabetes mediated via risk factors type diabetes failure consider severity frequency abuse may limit understanding importance risk factor diabetes
introduction understanding protective factors associated adolescent contraceptive use guide strategies prevent unprotected sex consequences current study investigated associations set protective factors specifically indicators positive youth development consistency contraceptive use method cross sectional study examined relationships positive youth development indicators consistency contraceptive use among sexually active adolescent girls elevated risk pregnancy multivariate models assessed whether measures individual attributes social attachments social norms associated consistent condom hormonal contraceptive use results adolescents higher self esteem greater family connectedness reported consistent hormonal contraceptive use two factors stress management skills perceived peer prosocial norms protective consistent condom use contrast steady partnership status associated less consistent condom use discussion findings suggest interventions targeting protective factors may influence adolescents contraceptive use addition promoting healthy development
intermittent smokers increased health risks compared non smokers cigarette smoking remains prevalent among men sex men msm persons living hiv plwh yet studies plwh discriminate daily smokers study characteristics quit intentions compared sample heavy drinking hiv infected msm participants enrolled reported smoked cigarettes past month among compared significantly likely white college degree higher reported significantly higher average number drinks per week compared compared significantly likely report future quit intentions within months compared intentions likely report immediate quit intentions within days compared future quit intentions among heavy drinking msm living hiv intermittent smoking associated white college educated future quit intentions considering smoking may less driven nicotine dependence tailored approaches smoking cessation may needed specifically may important interventions address social situational cues smoke including influence heavy alcohol use smoking behaviors provide information regarding adverse health effects even low level smoking
although catharsis theory applied violent media repeatedly refuted literature scholars recently proposed methods cognitive form catharsis might occur people utilize games manage negative affect drawing ideas current study tests video games used manage feelings frustration boost one sense competency also explores emotional processes influence game enjoyment hostile attribution bias hab frustrated half participants prior randomizing play violent nonviolent game results showed frustrated participants motivated progress farther video game game performance decreased feelings frustration boosted sense competency increased enjoyment game however played violent game enjoyment predicted hostile attributions high enjoyment violence increased hab low enjoyment violence decreased hab findings implications video games used manage negative feelings elsevier ltd rights reserved
time varying flow studied experimentally anatomically accurate model human airways mouth several generations bronchial branching airway geometry obtained scan healthy adult male normal height build three component three dimensional mean velocity field obtained throughout entire model using phase locked magnetic resonance velocimetry pulsatile pump drives sinusoidal waveform inhalation exhalation frequency stroke length mean trachea reynolds number peak inspiration womersley number integral parameters defined quantify degree velocity profile non uniformity related axial dispersion secondary flow strength lateral dispersion found extrathoracic airways significantly modify tracheal flow flow first bifurcation highly asymmetric effect flow oscillation produce time dependent flow features asymmetric respect acceleration deceleration periods surrounding peak inhalation exhalation pronounced regions separation secondary flow structure sensitive local attributes real anatomy reflected integral parameters behave non monotonically successive bronchial generations general measured oscillatory flow realistic anatomy confirms many trends derived idealized models also possesses qualitatively different large scale flow structures compared idealized representations upper airways elsevier inc rights reserved
violations second law relevant length time scales become small second law needs replaced fluctuation theorem mathematically irreversible entropy submartingale first discuss consequences results axioms continuum mechanics arguing favor framework relying stochastic functionals energy entropy next determine lyapunov function diffusion type problems governed stochastic rather deterministic functionals internal energy entropy random field coefficients diffusion required satisfy positive definiteness everywhere next formulation micropolar fluid mechanics developed accounting lack symmetry stress tensor molecular scales framework applied employed show spontaneous random fluctuations microrotation field arise couette poiseuille type flows absence random turbulence like fluctuations classical velocity field finally permeability classically modeled darcy law modifications besides considering violations second law one also needs account spatial randomness channel network implying modification hierarchy scale dependent bounds macroscopic property network
show possible called weak locking capacity quantum channel guha phys rev much larger private capacity reflect different ways capturing notion reliable communication via quantum system leaking almost information eavesdropper difference latter imposes intrinsically quantum security criterion whereas former requires weaker classical condition channels separation straightforward establish complementary channels classical quantum channels hence subclass hadamard channels also prove certain symmetric channels related photon number splitting positive weak locking capacity presence vanishingly small pre shared secret whereas private capacity zero findings powerful illustrations difference two apparently natural notions privacy quantum systems relevant also quantum key distribution older one based accessible information contrasting new composable one embracing quantum nature eavesdropper information assuming additivity conjecture constrained minimum output nyi entropies techniques first part demonstrate single letter formula weak locking capacity complements channels coinciding general upper bound guha channels furthermore still assuming additivity conjecture upper bound given operational interpretation general channels maximum weak locking capacity channel activated suitable noiseless channel
aimto develop experimental multi domain interventions older people mild moderate dementia evaluate effect delaying cognitive physical decline improvement prevention geriatric syndromes year follow methodsparticipants aged years older mild moderate dementia clinical dementia rating cdr grouped intervention jia veterans home usual care model community memory clinic residents jia veterans home received comprehensive intervention including multi disciplinary team consultation intervention multi component non pharmacological management geriatric syndromes survey intervention cga dementia friendly medical green channel approach mcga decline cognitive physical function determined change mini mental state examination score cdr sum cdr box well activities daily living based barthel index also screened geriatric syndromes baseline year later resultsparticipants intervention group older lower educational level lower body mass index poor baseline activities daily living function lower visual impairment higher rates hearing impairment polypharmacy risk malnutrition residents receiving mcga lower baseline mini mental state examination scores higher cdr residents jia veterans home cognitive measurements except mini mental state examination significantly associated delaying decline cognition analyzing multiple linear regression multivariate logistic regression also showed patients living community independently associated higher odds ratio activities daily living decline also improvement baseline geriatric syndromes suffered less new geriatric syndromes including falls urinary incontinence risk malnutrition conclusionsthe mcga intervention shows strong delays decline cognition physical function older residents mild moderate dementia furthermore strategy also improve prevent onset new geriatric syndromes especially fall episodes urinary incontinence risk malnutrition geriatr gerontol int suppl
polymorphisms methylenetatrahydrofolate reductase mthfr gene polymorphism atp binding cassette abcb gene reported pharmacogenetic markers influencing methotrexate mtx therapeutic outcome rheumatoid arthritis patients aims study determine relationship polymorphisms clinical response adverse drug reaction adrs mtx treatment cohort study composed patients west algerian population clinical response evaluated using disease activity score das adrs collected physical examination patients samples genotyped theses polymorphisms taqman allelic discrimination assay based eular criteria patients responders adrs observed patients frequency distribution three polymorphisms similar responders non responders result found adrs study significant difference distribution presence adrs group absence adrs group observed study joins results found others population world demonstrated first time west algerian population polymorphisms predictive clinical response adrs mtx therapeutic outcome
paper method used construct infinitely many conservation laws lax pair generalized dimensional nonlinear evolution equations nlees dimensional ones besides apply method kadomtsev petviashvili davey stewartson equations fluids respectively obtain infinitely many conservation laws symbolic computation based method also construct infinitely many conservation laws multidimensional nlees possessing lax pairs including cylindrical modified dimensional gardner equations fluids plasmas optical fibres bose einstein condensates
prominent component human fetal brain structure cerebral wall characterized laminar organization includes radial glial scaffold fetal development diffusion tensor imaging dti useful quantitatively delineate microstructure developing brain clearly identify transient fetal layers cerebral wall study spatio temporal microstructural changes developing human fetal cerebral wall quantitatively characterized high resolution dti data postmortem fetal brains gestational weeks eleven regions interest layer entire cerebral wall included distinctive time courses microstructural changes revealed regions neocortical plate histological analysis also integrated elucidate relationship dti fractional anisotropy histology high values correlated organized radial architecture histological image expression levels genes quantified regions human fetal neocortex gestational weeks identify transcripts showing significant correlation change correlations suggest heterogeneous regionally specific microstructural changes human neocortex related different gene expression patterns
finfet technologies becoming mainstream process technology scales based bulk finfets planar transistors three dimensional technology computer aided design tcad simulations performed investigate charge collection mechanisms single event transient set pulse widths nanoscale devices simulation results show charge collection set pulse widths finfets smaller planar device overall analysis indicates hits reduced charge collection finfet induced mainly narrow sensitivity drain volumes ion linear energy transfer lets less mev however parasitic bipolar amplification effect presents important effect charge reduction higher ion lets depth analysis shows reduced bipolar amplification effect finfet owing conduction channel fin body rather source drain region due parasitic reversed bipolar effect single event response hit less sensitive hit moreover comparisons temperature dependence set pulse width finfets planar devices carried indicate set pulse width pmos shows stronger temperature dependence finfet gives new insight single event effects see finfets provide guidelines future radiation hardened applications finfet based circuits
study determine role mechanism crocin rheumatoid arthritis totally wistar rats randomly divided control group model group methotrexate group crocin high dose middle dose low dose groups paw swelling degree arthritis score thymus spleen index mrna protein levels inos serum content tnf evaluated crocin treatment significantly alleviated paw swelling rats arthritis score crocin treatment groups significantly lower model group additionally thymus index spleen index declined remarkably crocin treatment groups model group besides crocin administration significantly reduced inos production serum content tnf crocin may exert potent anti effects inhibiting cytokine
aquaculture fish feeding behavior culture conditions holds important information aquaculturist study near infrared imaging used observe feeding processes fish novel method quantifying variations fish feeding behavior first images fish feeding activity collected using near infrared industrial camera installed top tank binary image fish obtained following series steps image enhancement background subtraction target extraction moreover eliminate effects splash reflection result reflective frame classification removal method based support vector machine gray level gradient occurrence matrix proposed second centroid fish calculated order moment centroids used vertex delaunay triangulation finally flocking index fish feeding behavior fiffb calculated quantify feeding behavior fish shoal according results delaunay triangulation fiffb values removed reflective frames fitted least squares polynomial fitting method results show variations fish feeding behaviors accurately quantified analyzed using fiffb values linear correlation coefficient versus expert manual scoring reached method provides effective method quantify fish behavior used guide practice elsevier rights reserved
research based taiwan first zero carbon green building magic school green technology national cheng kung university actual energy consumption measured explore benefits energy saving design origin building encompasses green energy saving techniques united states department energy dynamic building energy analytical software equest used execute strictest energy consumption analytical assessment forecasted reach energy saving efficiency energy use intensity eui kwh whole building far kwh found taiwan low mid rise office buildings building begun operation actual readings building energy management system bems january september first half year accumulated eui kwh equest analytical assessment kwh period demonstrating equest analytical assessed value consistent building actual energy consumption readings energy consumption standard experimental research behind magic school green technology stands world class
work describes rtpv phc initial prototype radioisotope thermophotovoltaic rtpv system using two dimensional photonic crystal emitter low bandgap thermophotovoltaic tpv cell realize spectral control validated system simulation using measurements rtpv phc comparison setup rtpv flatta configuration except polished tantalum emitter emitter rtpv phc powered electric heater providing energy equivalent one plutonia fuel pellet reached degrees thermal input power produced output power tpv cell compared system performance using photonic crystal emitter polished flat tantalum emitter found spectral control photonic crystal four times efficient based simulation cell areas better tpv cells improved insulation design system powered fuel pellet equivalent heat source expected reach efficiency elsevier rights reserved
effect treatments different concentrations honey water water water water followed coating soy protein isolate water fresh cut kajari melons investigated effect honey separately without soy protein isolate coating also investigated treatments given prior pacldng samples polypropylene trays stored degrees sensory overall shelf life studies total eight combinations samples three replicates analyzed various quality attributes throughout storage life highest weight loss occurred untreated melon samples sample treated honey water spi water maintained highest total soluble solids throughout storage sensory scores given control sample day storage samples treated honey lof water showed better results terms sensory characteristics ripening index decreased remarkably storage period control sample reaching lowest values comparison treated samples total plate count log colony forming units per gram cfu control sample counts less log cfu treated samples observed end storage elsevier ltd rights reserved
accumulating evidence brain structural imaging studies supported chronic pain could induce changes brain gray matter volume however studies focused gray matter alterations trigeminal neuralgia study twenty eight patients thirteen females mean age years healthy controls thirteen females mean age years included using voxel based morphometry vbm detected abnormalities gray matter volume patients based voxel wise analysis group showed significantly decreased gray matter volume bilateral superior middle temporal gyrus stg mtg bilateral parahippocampus left anterior cingulate cortex acc caudate nucleus right fusiform gyrus right cerebellum compared addition found gray matter volume bilateral stg mtg negatively correlated duration results provide compelling evidence gray matter abnormalities suggest duration may critical factor associated brain alterations
energy harvesting one techniques high interest approaching global energy problem without depleting natural resources energy harvesting technology road new research area energy surrounding road space available many different forms wind solar thermal mechanical energy goal study determine possibility energy harvesting technology pavement absorbs solar radiation thus increasing internal temperature temperature difference maintained atmospheric temperature pavement surface temperature difference tapped converted electrical energy using thermoelectric module device module device system captures energy temperature difference based seebeck effect paper describes various application procedures pavement system focuses development energy harvesting system energy use present research indicates limited simple system study used capture heat energy pavement shows promise supporting power waste solar energy roads also module placed within road space whereas solar panels exposed sunlight
environmental enteropathy syndrome altered small intestine structure function hypothesized common among individuals lacking access improved water sanitation plausible biological mechanisms inflammatory non inflammatory may alter cardiometabolic profile test hypothesis associated cardiometabolic profile among young children living environment intense enteropathogen exposure total children participating peruvian cohort multicenter study childhood infectious diseases growth development contacted years age urinary lactulose mannitol ratio plasma antibody endotoxin core determined order assess intestinal permeability bacterial translocation blood pressure anthropometry fasting plasma glucose insulin cholesterol apolipoprotein profiles also assessed extant cohort data also used relate biomarkers first months life early child cardiometabolic profile lower intestinal surface area assessed percent mannitol excretion associated lower apolipoprotein lower high density lipoprotein concentrations lower intestinal surface area also associated greater blood pressure inflammation months age associated higher blood pressure later childhood study supports potential relationship cardiometabolic profile
ivabradine bradycardic agent shown stably reduce patient heart rate setting acute cardiac care however association atrial fibrillation risk acute ivabradine treatment remains controversial clinical issue thoroughly investigated bradycardia abnormal atrial refractoriness induced ivabradine treatment may enhance vulnerability induction especially vagal nerve concurrently activated aimed experimentally investigate effects acute ivabradine treatment without concurrent vagal activation inducibility anesthetized dogs cervical vagal nerves prepared electrical stimulation induction rate afir determined atrial burst pacing atrial action potential duration apd atrial effective refractory period erp afir obtained consecutively baseline delivery alone intravenous injection ivabradine ivabradine group saline saline group delivery drug ivabradine group ivabradine alone significantly lowered compared baseline ivabradine significantly lowered compared alone contrary expectations significant differences trends apd temporal dispersion apd erp afir ivabradine saline groups irrespective whether ivabradine saline injected significantly shortened apd erp increased afir interestingly although bradycardia response ivabradine injection intense alone afir significantly lower ivabradine injection alone conclude despite intense bradycardic effect acute ivabradine treatment increase inducibility irrespective underlying vagal activity study may constitute support safety using ivabradine setting acute cardiac care
introduction psoriatic arthritis psa heterogeneous chronic inflammatory disease characterized wide clinical spectrum early diagnosis psa currently challenging topic areas covered literature extensively reviewed studies addressing topic area diagnosis psoriatic arthritis review summarize improvements diagnostic tools especially referral rheumatologist role patient history clinical examination laboratory tests imaging techniques getting early correct diagnosis psa expert commentary due heterogeneity expression psa may easily either overdiagnosed underdiagnosed diagnosis psa taken account every time patient psoriasis family history psoriasis shows peripheral arthritis especially oligoarticular involving distal interphalangeal joints enthesitis dactylitis magnetic resonance imaging ultrasonography useful diagnosing psa early particularly isolated enthesitis inflammatory spinal pain occur
recent work shown robust associations morality cleanliness however known whether association equally consequential everyone predicted individuals high low god belief would likely draw upon feelings cleanliness represent moral concerns test hypothesis used week daily sampling protocol initial session measured participants level god belief measured participants levels daily cleanliness neuroticism impulsivity prosocial behaviors every evening daily feelings cleanliness predicted lower levels neuroticism high god belief daily impulsive behaviors predicted lower feelings cleanliness daily prosocial behaviors predicted higher feelings cleanliness god belief moderated effects stronger higher lower god belief closing discuss potential reasons moderation effects theoretical considerations
basidiomycetous fungi ganoderma lucidum mdu ganoderma secreted multiple laccase isozymes diverse growth condition aromatic compounds metal salts also found regulate differential expression laccase isozymes ganoderma laccase isozymes induced presence copper lucidum mdu purified gel based native page purification method purity laccase isozymes checked zymogram sds page sds page purified proteins confirmed multimeric nature laccase isozymes molecular mass isozymes found range kda purified laccase isozymes peptides confirmed help maldi tof peptide fingerprinting biochemical characterization laccase isozymes viz glac glac glac glac shown optimum temperature range degrees degrees values laccase isozymes determined guaiacol abts tolidine laccase isozymes lucidum whole genome studied using bioinformatics tools molecular modeling docking laccase isozymes different substrates showed significant binding affinity validates experimental results interestingly copper induced laccase culture medium found significantly induce cotton callogenesis interestingly laccase isozymes found antioxidative role therefore capable free radicals scavenging callogenesis first detailed study biochemical characterization laccase isozymes purified gel based novel method
uncertainty forest information typically results economic ecological losses consequence suboptimal management decisions several techniques proposed handle uncertainties however techniques often complex costly data assimilation recently advocated tool may reduce uncertainty thereby improving quality forest planning results offers opportunity make use new sources information systematic way thus provides accurate date information forest planning study refer literature handling uncertainties forest planning well related literature scientific fields assess potential benefits using forest planning identify five major potential benefits accuracy information improved information kept date iii process provide information estimated accuracy stochastic decision making applied whereby accuracy information utilized decision making process data allows analysis optimal data acquisition decisions
implementation intraoral extraoral computer aided design computer aided manufacturing cad cam systems prosthetic dentistry simplified procedure shortened period design manufacture improved accuracy aesthetic properties dental restorations three dimensional digitisation become adequate replacement conventional dental impressions market offers variety diverse optical intraoral extraoral cad cam systems equipped digitisation devices based different working principles main goal research determine whether precision accuracy differ among optical digitisation devices research includes five high end devices cerec cerec ineos trios kavo everest sinergia scan evaluation methodology experiment based cad inspection results obtained accuracy precision measurements tolerance levels indicate difference accuracy precision optical digitisation devices based different working principles
decreased effectiveness bones adaptive response mechanical loading contributes age related bone loss young mice intermittent administration parathyroid hormone ipth day interacts synergistically artificially applied loading increase bone mass report investigations effect different doses duration ipth treatment mice whose osteogenic response artificial loading impaired age one group aged month old female cbl mice given day ipth weeks histological analysis tibiae revealed potent ipth dose related increases periosteally enclosed area cortical area porosity decreased cortical thickness practically effect trabecular bone another group given submaximal dose day ipth vehicle weeks loading right tibia three times per week final weeks trabecular bone mice loading related increase abrogated ipth primarily reduction increase trabecular number cortical bone ipth treatment time dependently increased cortical porosity loading partially reduced effect osteogenic effects ipth loading periosteally enclosed area cortical area additive synergistic thus aged unlike young mice ipth loading appear separate effects ipth alone causes marked increase cortical porosity loading reduces ipth loading positive effects cortical periosteal bone formation additive rather synergistic authors published elsevier inc
software engineering standards often utilize different underpinning metamodels ontologies sometimes differ standards better adoption industry harmonization standards use domain ontology advocated paper apply approach proof concept project recommend creation single underpinning abstract domain ontology created existing iso iec standards including iso iec supplemented sources authorized appropriate useful adoption single ontology permit engineering existing international standards refinements domain ontology variously focussed standards inter operate elsevier rights reserved
objectivedsm revised diagnostic criteria anorexia nervosa eliminating amenorrhea requirement liberalizing weight psychological criteria adding formal diagnosis atypical individuals psychological symptoms without low weight sought determine whether bone density bmd impaired women diagnosed using new liberal dsm criteria methodcross sectional study women dsm dsm dsm dsm criteria dsm atypical atypical healthy comparison group measurements included dual energy ray absorptiometry eating disorder examination questionnaire eating disorder inventory hamilton depression anxiety rating scales resultsbmd score present dsm dsm atypical mean scores comparably low dsm dsm intermediate atypical highest lack prior low weight amenorrhea history overweight obesity protective bone loss mean lean mass percent fat mass significantly lower groups dsm dsm atypical comparable psychopathology discussiondespite liberalizing diagnostic criteria many women diagnosed atypical using dsm criteria low bmd presence history low weight amenorrhea remain important indications dxa loss lean mass addition fat mass present groups may contribute low bmd deleterious effect eating disorders bmd extends beyond current low weight amenorrhea wiley periodicals inc int eat disord
compared traditional suspension footbridges cable truss footbridge always easier satisfy structure deformation requirements small dead load live load ratio condition enjoys surging popularity western china type bridges deck system designed pure local load bearing member inverse pre tensioned deck cable system set form tension tension mechanical system better understand structural performance simplified structural mechanics model cable truss footbridges proposed analytical formulations deformation internal forces bridge entire span live load well semi span live load derived reliability accuracy proposed model validated comparison study finite element analysis furthermore series qualitative quantitative parametric studies conducted reveal cable truss bridges several novel structural characteristics differ traditional suspension bridges finally affordability range cable truss bridges also discussed using material usage analysis elsevier ltd rights reserved
apples widely consumed fruit high polyphenol content aim study analyse combined effects osmotic dehydration ohmic heating pulsed vacuum polyphenol retention stored refrigeration apple cubes treatments performed using degrees brix sucrose solution degrees min samples stored days degrees provides electric field pulsed vacuum applied min beginning process results indicated lower temperature process degrees resulted retention polyphenol compounds treatment higher temperature process degrees nevertheless refrigerated storage observed degrees preserved compounds better due polyphenol oxidase inactivation pvod treatment degrees determined best retention polyphenols fresh apple dehydrating apples
halogen bond topical noncovalent interaction rapidly increasing importance employs soft donor atom comparison hard proton hydrogen bond difference led hypothesis xbs form favorable interactions soft bases hbs computational studies supported suggestion solution solid state data lacking soft soft complementarity investigated bidentate receptor shows similar associations neutral carbonyls heavy chalcogen analogs solution speciation soft soft complementarity supported four crystal structures containing neutral anionic soft lewis bases
purpose lower urinary tract symptoms common united states population leading significant economic quality life public health issues burden increase population ages risk factors lower urinary tract symptoms including diabetes obesity remain highly prevalent improving clinical management establishing knowledge base prevent lower urinary tract symptoms require comprehensive research approach examines factors beyond lower urinary tract study extra lower urinary tract factors increased recently current urological research systematically account broad set potential contributing factors spanning biological behavioral psychological executive function sociocultural factors comprehensive assessment potential contributors risk treatment response progression necessary reduce burden condition united states materials methods considered challenges continuing predominantly lower urinary tract dysfunction centric approach dominated previous research lower urinary tract symptoms results developed new comprehensive framework urology research includes broader set potential factors contributing lower urinary tract symptoms framework aims broaden research consider comprehensive set potential contributing factors engage broad range researchers investigation many extra lower urinary tract factors possible goal improving clinical care prevention conclusions propose new framework future urology research help reduce medical economic burden lower urinary tract symptoms united states population
recent years transportation electrification emerged trend support energy efficiency emissions reduction targets true success however trend depends successful integration electric transportation modes infrastructure systems support left unmanaged plug electric vehicles may suffer delays due charging cause destabilizing charging loads electrical grid online electric vehicles emerged remediate need stationary charging effects many works sought mitigate effects advanced control functionality coordinated charging vehicle grid stabilization charging queue management works assessed impacts holistic transportation electricity nexus paper develops hybrid dynamic system model transportation electrification also includes next generation traffic simulation concepts multimodality multiagency model used electrified transportation fleet operators assess also improve operations control hybrid dynamic system model composed marked petri net model superimposed continuous time kinematic electrical state evolution model demonstrated illustrative example moderate size functional heterogeneity
background hypothesized survival implantable cardioverter defibrillator icd cardiac resynchronization therapy defibrillator crt patients predicted baseline heart rate score methods heart rate score determined atrial paced sensed histogram ddd icd crt defined percent beats histogram tallest beats min range bin calculated initial remote monitoring patients enrolled latitude without persistent atrial fibrillation pulse generators implanted univariate multivariate kaplan meier analyses determined impact heart rate score survival results icds crt followed years increase heart rate score associated decreased survival crt hazard ratio confidence interval icd confidence interval conclusion simple device histogram measure heart rate score predicts survival icd crtd patients independent available variables even sdann unavailable
paper adaptive synchronous rectifier driving scheme llc resonant converters using ripple counter concept proposed along two methods implementation proposed scheme drain source voltage sensed detect body diode conduction based time well tuned eliminate body diode conduction one proposed implementation tunes time every switching cycle based ripple detection another proposed implementation tunes time every nth switching cycle based ripple counter suitable high frequency llc converters proposed driving scheme simple implementation requires low cost digital controllers occupies controller resources importantly since digital controllers already widely adopted control llc converters proposed adaptive driving method embedded digital controllers little extra cost furthermore integrate proposed driving method closed loop control explained details experimental results demonstrated khz llc converter mhz microcontroller mcu khz llc converter mhz mcu ripple counter
purpose investigate relative effect response outcome expectancies work conditions number subjective health complaints shc anxiety depression norwegian employees learned response outcome expectancies important contributors health individual differences expectancy cope workplace general life demands may important work conditions influence health method survey conducted among municipal employees mean age female part randomized controlled trial cross sectional study used baseline data multiple logistic regression analysis performed outcome variables anxiety depression response outcome expectancies work conditions number shc independent variables results high number shc significant factor explaining anxiety depression comorbid anxiety depression high degree negative response outcome expectancies significant factor explaining depression comorbid anxiety depression variance accounted full models anxiety depression comorbid anxiety depression conclusion high number shc high degree negative response outcome expectancies associated anxiety depression strongest association found number shc however previous studies indicate may possible prevent occurrence shc suggest workplace interventions targeting anxiety depression could focus influencing altering employees response outcome expectancies
paper presents temperature compensated cmos current reference low line regulation current mirror circuit based bandgap reference voltage achieves temperature compensation resistor negative temperature coefficient high resistance polysilicon poly resistor positive well resistor low line regulation current mirror implemented using negative feedback connected operational amplifier prototypes current reference cmos process show maximum temperature coefficient ppm degrees temperature range degrees line regulation reduced supply voltage
different epithelia intestinal epithelium complex task providing barrier impeding entry toxins food antigens microbes time allowing transfer nutrients electrolytes water microbial metabolites molecules organisms transported either transcellularly crossing apical basolateral membranes enterocytes paracellularly passing space enterocytes accordingly intestinal epithelium affect energy metabolism fluid balance well immune response tolerance help accomplish complex tasks intestinal epithelium evolved many sensing receptor mechanisms yet roles functions beginning elucidated article explores one sensing receptor mechanism carried extracellular calcium sensing receptor casr addition established function nutrient sensor coordinating food digestion nutrient absorption regulating energy metabolism present evidence emerging role casr control intestinal fluid homeostasis immune balance additional role modulation enteric nerve activity motility also discussed clearly casr profound effects many aspects intestinal function nevertheless work needed fully understand functions casr intestine including detailed mechanisms action specific pathways involved considering essential roles casr plays gastrointestinal physiology immunology research may lead translational opportunity development novel therapies based casr unique property using simple nutrients calcium polyamines certain amino acids oligopeptides activators possible targeting intestinal casr combination specific nutrients oral solutions inexpensive practical may developed help conditioning gut microenvironment maintaining digestive health
effective lane detection algorithm employing hough transform inverse perspective mapping estimate distances real space utilized send steering control commands self driving vehicle vehicle capable autonomously traversing long stretches straight road wide variety conditions set algorithm design parameters better performance hampered slowly updating inputs steering control system frames per second fps using raspberry image capture processing improved fps odroid even fps vehicle capable navigating structured unstructured roads slow speed
objective study develop new elaborate method evaluate infants liking foods could applied home compare results elaborate method basic method mothers infants aged months participated study basic method mothers asked assess infant global liking end meal elaborate method mothers received detailed instructions feed infant infants might express like dislike stop meal first nine spoons asked report presence absence positive negative behaviours spoon infant initial liking reported triplet spoons also assessed infant global liking end meal methods applied using three commercial familiar baby foods adapted age range month olds elaborate method showed significant difference across products liking whereas basic method show difference month olds elaborate method showed differences across products liking basic method age groups negative behaviours despite less frequently reported provided better liking discrimination positive behaviours conclusion elaborate method produced better product liking discrimination basic method focusing maternal attention infants eating behaviours since first spoons elsevier ltd rights reserved
background effects overt hypothyroidism pregnancy outcomes foetal development well established treatment protocol reputable method material prevalence effects subclinical hypothyroidism sch pregnancy yet clear hence universal screening pregnant women still debatable treatment detected sub clinical hypothyroidism yet general consensus data regarding beneficial effects treatment mother foetus sch cases inadequate result odisha known endemic area iodine deficiency reports occurrences sch odisha limited study case series done detect prevalence sch pregnancy ante natal unit medical college hospital catering large population odisha conclusion prospective study included screening pregnant women thyroid function follow cases sch till confinement record adverse effects thyroid dysfunction obstetric outcome
suicide rate females china second highest worldwide china country world rate suicides higher women men affective instability shown strong predictor suicidal ideation particularly among women however prior research mainly focused impact women negative affect suicidal ideation ignoring influence positive affect suicidal ideation studies revealed hopelessness times important depression explaining suicidal ideation driven low levels positive affect high levels negative affect although positive affect also found related suicidal ideation demonstrates independent beneficial effects mental health much remains learned association positive affective instability suicidal ideation therefore investigated prevalence suicidal ideation among chinese working women explored differences working women without suicidal ideation intensity daily variability positive affect total young working women ages years recruited free weekend psychology lecture women subsequently completed daily diary day reconstruction method drm well suicidal ideation questionnaire used hierarchical linear modeling hlm analyze data results showed participates reported suicidal ideation intensity positive affect happiness warmth friendliness interest relaxation calmness significantly lower women suicidal ideation compared women without suicidal ideation differing diurnal patterns positive emotions observed women without suicidal ideation women suicidal ideation demonstrated significantly lower trend growth higher volatility happiness warmth friendliness relaxation calmness given lower intensity positive affect greater affective instability significantly predicted suicidal ideation chinese women researchers pay attention role positive affect female suicide prevention research intervention efforts future
prototype wearable exoskeleton three degrees freedom presented paper design considers multiple user acceptance criteria functional requirements aim facilitate robotic assisted home rehabilitation therapy actuation modules containing shape memory alloy sma wires mechanical amplification position sensors designed meet work requirements activities daily living modules containing differential configuration spring bias configuration built presented kinematic dynamic models presented simplified material model relates system inputs sma strain rate derived validated using open loop tracking results combined gain scheduled servo loop disturbance rejection create feedforward controller dules controller showed reasonable results tracking sinusoidal trajectories friction controller parameters contributing velocity instability theory stiffness control differential configuration requirement control heating cooling rates presented miniature fans fitted control cooling rate however unsuccessful probably due dominance conduction heat transfer within design modular actuators tested extracted exoskeleton design results lead conclusion following aspects require improvement testing proceeds user integration force sensors control loop hardware improves controlled cooling rate qualitative analysis friction system
letter consider long capillary gravity waves described fully nonlinear weakly dispersive model first using phase space analysis methods describe possible types localized travelling waves especially focus critical regime surface tension exactly balanced gravity force show long wave model critical bond number admits stable travelling wave solutions singular crest solutions usually referred literature peakons peaked solitary waves satisfy usual speed amplitude relation coincides scott russel empirical formula solitary waves decay rate regardless amplitude moreover depression elevation type independent speed dynamics solutions studied well elsevier rights reserved
hypoxia hypoxia inducible factor hif transcription factor drive pathological bone loss conditions including rheumatoid arthritis osteoarthritis osteoporosis primary bone tumours bone metastatic cancer therefore considerable interest determining function hif induced genes pathologies angiopoietin like angptl adipose derived hif alpha ppar gamma induced gene originally discovered endocrine autocrine paracrine regulator lipid metabolism given inverse relationship bone adiposity fracture risk angptl might considered good candidate mediating downstream effects hif alpha relevant osteolytic disease review consider possible roles angptl regulation osteoclast mediated bone resorption cartilage degradation angiogenesis inflammation focusing results obtained study possible roles musculoskeletal pathologies also discussed highlight angptl regulator multiple disease processes could represent novel therapeutic target osteolytic musculoskeletal disease
recent years many researchers studied reversible watermarking techniques relational databases developed schemes based primary key attribute order determine selected tuples attributes carry watermark bits happens however primary key attribute exist relational database paper propose blind robust reversible watermarking scheme textual relational database scheme rely primary key attribute avoid absolute dependence primary key attribute existing schemes proposed scheme content textual attributes used generate virtual primary attribute applied tuple attribute selections moreover selection attributes depend order attributes relational database model robustness analysis demonstrate proposed scheme achieves high resilience different types tuple attacks tuple attacks attribute attacks experimental results also confirm proposed scheme secure robust existing schemes
objectiveperianal disease debilitating condition frequently occurs crohn disease patients currently unknown whether incidence changed era frequent immunomodulator use biological availability studied incidence outcome perianal rectovaginal fistulas past two decades population based inflammatory bowel disease south limburg cohort patients methodsall patients registered inflammatory bowel disease south limburg registry included cumulative probabilities developing perianal rectovaginal fistula compared three eras distinguished year diagnosis second clinical risk factors risk fistula recurrence determined resultsthe cumulative year perianal fistula rate era era era colonic disease associated increased risk developing perianal disease whereas older age associated decreased risk time patients exposed immunomodulators biologicals fistula diagnosis respectively started biological therapy thereafter respectively cumulative year perianal fistula recurrence rate significantly different eras contrast cumulative year rectovaginal rate attenuated era era conclusionover past two decades risk developing perianal fistula stable well recurrence rate underlining lasting need improving treatment strategies invalidating condition copyright wolters kluwer health inc rights reserved
human aggression encompasses wide range behaviors related many psychiatric disorders introduce different classification systems aggression related disorders basis discussing biochemical biomarkers present overview studies humans published reported statistically significant associations biochemical biomarkers aggression dsm disorders involving aggression subtypes markers different types including inflammation markers neurotransmitters lipoproteins hormones various classes studies focused limited portfolio biomarkers frequently specific class integrating data clear compounds several biological pathways found associated aggressive behavior indicating complexity need broad approach second part paper using examples aggression literature psychiatric metabolomics studies argue better understanding aggression would benefit holistic approach provided metabolomics wiley periodicals inc
background low birth weight lbw considered leading cause cognitive impairment physical disabilities children incidence lbw south asia reported high investigated association antenatal depression lbw urban community karachi pakistan methods total pregnant women third trimester recruited study screened antenatal depression edinburgh postnatal depression scale self reporting questionnaire also used measure psychological distress birth weights newborns obtained hospital records results find significant association antenatal depression lbw odds ratio mothers attending charity run hospital urban setting pakistan conclusion antenatal depression associated lbw urban population pakistan however prevalence depression high pregnancy need develop culturally adapted psychosocial interventions address high rates depression population group
susquehanna river basin srb largest watershed draining atlantic coast encompasses portions new york pennsylvania maryland given annual maximum flood events commonly result either rain snow hurricanes tropical storms determining potential impacts climate change flooding behavior especially challenging paper presents modeling system captures dominant flooding processes well suited future research investigating impacts regional climate change study coupled hydrologic hydraulic model developed used estimate hourly streamflow period capturing range annual maximum discharge phenomenon rain snow localized convective events hurricanes tropical storms three layer variable infiltration capacity vic model used generate surface runoff vertical flux water root zone scale degrees used inputs hillslope river routing hrr model operates irregular grid mean length scale simulate lateral surface subsurface transport channel hydraulics coupled model validated using usgs daily streamflow snow water equivalent swe derived advanced microwave scanning radiometer eos amsr satellite snow depth situ measurements coupled model vic hrr shows good performance seasonal baseflow patterns large flood events rain snow hurricane tropical storms given srb commonly subjected two types flood events role snow processes investigated comparing synthetic model scenarios without snow processes suggests future climate conditions reduce winter snowfall due warmer temperatures maintain total precipitation levels annual runoff increase mean annual peak discharge decrease
lead lithium cooled ceramic breeder llcb tbm indian demo relevant blanket module tested one half designated iter port day operation iter llcb tbm tested various iter operational phases different tbm may tested corresponding four different phases plasma operation paper present review thermal analyses based various heat loads llcb tbm obtained neutronics calculations confirm heat removal structural integrity different iter operational conditions includes normal plasma operation fusion power excursions surface heat flux due marfes disruption heat loads thermal current quench etc inductive non inductive plasma operations transient events like plasma disruption vertical displacement events vdes edge localized modes elms deliver considerable heat flux high power densities short durations onto first wall tbm detailed thermal hydraulic simulation studies performed using ansys analyses therefore provide important information temperature distribution different materials used tbm temperature time histories elsevier rights reserved
rainwater harvesting rwh techniques adapted arid semi arid regions minimise risk droughts demand water increased water resources become scarcer assessment modelling surface water related rwh catchments become necessity understanding hydrological processes sub catchment level generally lacking little attention given assessment rwh implementation objective study develop simple generally applicable water harvesting model test sub catchment level evaluate optimize performance rwh different design management scenarios model applied rainfall data sub catchments watershed wadi oum zessar south eastern tunisia performance analysis rwh three types years dry normal wet presented discussed study emphasises advantages simulating long term water balances sub catchment level improving understanding hydrological processes rwh system provides several solutions optimizing rwh performance various scenarios changing spillway heights together flow directions significant impact performance rwh making sub catchments supply sufficient water crop requirements compared sub catchments case changes elsevier rights reserved
introduction upper airway angioedema life threatening emergency department presentation increasing incidence angiotensin converting enzyme inhibitor induced angioedema aae non mast cell mediated etiology angioedema accurate diagnosis clinical examination optimize patient management reduce morbidity inappropriate treatment epinephrine aim study describe incidence angioedema subtypes management aae evaluate appropriateness treatments highlight preventable iatrogenic morbidity methods conducted retrospective chart review consecutive angioedema patients presenting two tertiary care eds july march results medical records screened included cause angioedema identified cases common identifiable etiology aae male predominance common aae management strategies included diphenhydramine corticosteroids ranitidine epinephrine administered aae patients five received repeated doses four aae patients required admission one required endotracheal intubation epinephrine induced morbidity two patients causing myocardial ischemia dysrhythmia shortly administration conclusion aae common identifiable etiology angioedema accurately diagnosed physical examination easily confused anaphylaxis mismanaged antihistamines corticosteroids epinephrine little physiologic rationale epinephrine use aae much risk improved clinical differentiation mast cell non mast cell mediated angioedema optimize patient management
quality life including domains physical health mental health influenced hiv infection coping strategies relationships various domains quality life qol assessed among hiv infected individuals pune india infected individuals adopted emotion focused strategies cognitive reframing acceptance hiv status one third adopted problem focused coping sought health care scientific information social support significant associations coping strategies observed marital status work earning domains qol questionnaire findings help decide appropriate care support strategies psycho social interventions hiv infected individuals
paper develops general regression framework analysis manifold valued response riemannian symmetric space rss association multiple covariates interest age gender euclidean space rss valued data arise frequently medical imaging surface modelling computer vision among many fields develop intrinsic regression model solely based intrinsic conditional moment assumption avoiding specifying parametric distribution rss propose various link functions map euclidean space multiple covariates rss responses develop two stage procedure calculate parameter estimates determine asymptotic distributions construct wald geodesic test statistics test hypotheses unknown parameters systematically investigate geometric invariant property estimates test statistics simulation studies real data analysis used evaluate finite sample properties methods
background objectives mothers living hiv encouraged breastfeed transmit hiv infants however little known thai women hiv perceive experience infant feeding practices paper explores breastfeeding experiences among thai women living hiv southern thailand methods semi structured interviews drawing methods used hiv positive women rural communities southern thailand thematic analysis used data analysis findings hiv positive mothers ambivalent feelings able breastfeed infants perceived contaminated mother healthcare centres hospitals supply free infant formula hiv positive mothers one half years despite many mothers deal difficulties infants developed allergy infant formula free infant formula sufficient infants mothers find alternative means well infants many mothers relied condensed milk whereas fed mashed banana women made every effort fulfill ideology good responsible mother conclusion paper contributes conceptual understanding lived experiences breastfeeding among women living hiv southern thailand findings implications midwifery care health policy provision different options feeding made available infants along accessible resources professional support guidance
examine recent dispute regarding centers medicare medicaid services cms refusal unconditionally pay amyloid positron emission tomography pet imaging medicare beneficiaries assessed alzheimer disease cms pay amyloid pet imaging patients enrolled clinical trials meet certain criteria dispute reflects cms willingness certain circumstances require effectiveness evidence differs food drug administration standard pre market approval medical intervention reveals stakeholders differing perspectives evidentiary standards played role attempting shape medicare program coverage policies
background dengue encephalitis rare neurological manifestation dengue fever clinical presentation similar viral encephalitides encephalopathy single specific finding magnetic resonance imaging dengue encephalitis yet documented highly variable atypical case presentation year boy presented fever headache altered sensorium day duration neurological examination glasgow coma scale score emv focal neurological deficit laboratory evaluation revealed leukopenia marked thrombocytopenia dengue virus igm antibody positive serum cerebrospinal fluid magnetic resonance imaging brain revealed signal changes bilateral parietooccipital left frontal regions left hemisphere involved right hemisphere gyriform enhancement bilateral parietooccipital regions consistent cortical laminar necrosis bilaterally diffuse subcortical white matter also involved subtle hyperintensity involving basal ganglia noted gradient echo sequence revealed presence hemorrhage subcortical white matter patient treated conservatively received platelet transfusion patient became fully conscious days conclusion patient highly suggestive dengue ephalitis describe unusual magnetic resonance imaging finding report possibly first instance cortical laminar necrosis setting
quality life qol key outcome people cerebral palsy executive functioning important predictor qol health related conditions little known association neural substrate aim analyze influence executive functioning including cognitive flexibility well psychological motor communication socioeconomic variables qol identify neuroanatomical areas related qol adolescents adults fifty subjects diagnosed dyskinetic mean age years recruited caregivers completed primary caregiver proxy report version qol teen questionnaire motor status communication four executive function domains anxiety depression socioeconomic status evaluated correlations multiple linear regression models used relate qol domains total score variables thirty six participants underwent mri assessment correlations examined cortical thickness qol total score cortical thickness variables might predict qol total score executive functions predict scores four domains qol general well participation communication physical health family health feelings functioning regression model among cognitive domains comprise executive function cognitive flexibility measured terms performance wisconsin card sorting test wcst predicts qol total score monthly income fine motor functioning communication ability predict scores domains access services family health feelings functioning school well respectively clusters resulting correlation cortical thickness qol total score wcst performance overlapped posterior cingulate precuneus cortices cognitive flexibility predicts proxy report qol teen total score dyskinetic relationship anatomical correlate posterior cingulate precuneus cortices
background hypertension chronic kidney disease ckd common conditions major risk factors cardiovascular events objectives study prevalence ckd hypertensive patients study association ckd cardiac vascular complications multicenter nation wide fashion methods cross sectional study evaluated patients aged years older diagnosed hypertension treated least months public hospitals thailand study period outcome measurements included calculated glomerular filtration rate gfr cardiac vascular complications included coronary artery disease stroke peripheral arterial disease heart failure atrial fibrillation multivariable modeling conducted determine independent factors associated increased risk cardiac vascular complications results total patients enrolled average age years male prevalence ckd stage respectively prevalence cardiac vascular complications coronary artery disease stroke heart failure atrial fibrillation ckd independent risk factor associated complications overall cardiac vascular complications adjusted odds ratio ckd stage ckd stage conclusion prevalence ckd stage hypertensive population ckd independent risk factor adverse cardiac vascular outcome
paper presents systematic literature review internet things ambient intelligence areas goal identify best software tools allow end users namely people without competencies computer programming manage configure behaviors smart home review selected papers papers found automatic manual search papers tools identified analyzed means eight technical characteristics finally among eleven tools six tools chosen qualitative comparison basis seven design principles smart home control proposed literature paper
objectives graves ophthalmopathy occurs graves disease cases treatment based smoking cessation control euthyroidism ocular repercussions associated disease active orbital forms treated glucocorticoids non validated therapies also recently tested rituximab effectively used several times treat corticosteroid resistant graves ophthalmopathy associated optic neuropathy use could proposed inflammatory ophthalmopathies failure corticosteroids present six cases treated since early university hospital center tours france methods six patients treated university hospital center tours france september april patients mourits score greater three treatment corticosteroids severe nospecs score orbital inflammation resistant maximal treatment intravenous injections methylprednisolone optic neuropathy twice received one gram rituximab slow intravenous injection two weeks apart efficacy assessed decrease orbital inflammatory clinical mourits score visual acuity visual field testing results inflammatory score patients improved treatment helped stop progression sequelae due neuropathy orbital inflammatory clinical score visual acuity visual field improved orbital decompression necessary complete treatment conclusion rituximab used treatment active corticosteroid resistant graves ophthalmopathies also positive results patients visual threat optic neuropathy combined surgical decompression published elsevier masson sas
filamentary rram role self heating set reset ion transport well established however nonfilamentary mno pcmo rram self heating set reset explored recently shown self heating explain nonlinearity characteristics paper present observation self heating using transient current pulses show cooling timescale limited bymeasurement system timescale similar self heating based experimental current transient timescale longer described simple exponential decay explain behavior self heating pcmo rram joule heating current increase create positive feedback implemented technology computer aided design simulations simulations produce excellent agreement experiments eventually simulations deviate experiments thermally assisted ionic transport set reset included model interrupt continuous self heating pulse train cooling time pulses versus single pulse based set reset experiment designed peak bias time set reset effectiveness degrades increases effect increasing cooling time confirmed cooling timescale similar overall self heating provides consistent explanation transient currents thus paper establishes self heating considerations must included pcmo based rram modeling design
paper presents new topology waveform generation using two current conveyors grounded capacitor resistor tuning uses current conveyors place voltage amps offer better linearity bandwidth slew rate thermal stability measured results obtained using commercially available devices adan passive components show excellent linearity tunability grounded resistor capacitor topologies range interest component sensitivity temperature sensitivity degrees degrees studied comparison existing candidate designs shows superiority proposed design aspects grounded connection tuning components makes digital control easy
purpose compare video computer game play patterns young adolescent boys girls including factors correlated playing violent games methods data collected november december children grades two demographically diverse schools pennsylvania south carolina using detailed written self reported survey results participants female male reported playing electronic games previous months children listed frequently played game titles almost half played least one violent mature rated game regularly boys girls one third boys girls play games nearly every day plays often always parent playing rated games positively correlated male frequent game play playing strangers internet game system computer one bedroom using games manage anger conclusions young adolescent boys many girls routinely play rated games implications identifying atypical potentially hannful patterns electronic game use discussed well need greater media literacy among parents society adolescent medicine rights reserved
child abuse associated number negative psychosocial outcomes including mental health problems substance abuse interpersonal violence yet children thrive adapt well despite experiencing abuse researchers increasingly interested protective factors mechanisms may prevent negative outcomes purpose study explore role resiliency characteristics relationship childhood abuse negative outcomes depression posttraumatic stress disorder ptsd substance abuse revictimization adolescent girls involved child welfare participants adolescent girls ages years youths color white data collected surveys assessing histories physical sexual emotional child abuse symptoms post traumatic stress depression lifetime substance use experiences physical verbal relational revictimization last three months forms childhood abuse significantly associated symptoms depression ptsd well revictimization substance use higher levels resiliency associated fewer depression ptsd symptoms experiencing less revictimization resiliency significantly moderated relationship sexual abuse depression ptsd revictimization resiliency also moderated relationship emotional abuse depression significant interactions emerged relationship physical abuse mental health behavioral problems study suggests resiliency may serve protective factor relationship abuse sexual emotional depression ptsd revictimization adolescence elsevier ltd rights reserved
objective objective present study analyze surgical safety retaining glands papillary thyroid microcarcinoma mptc patients methods cases mptc retrospectively reviewed divided four groups according treatment group conservative follow group cases group total resection unilateral gland combined isthmic resection cases group total resection unilateral gland combined subtotal resection contralateral gland cases group total resection bilateral glands cases average follow time months results occurrence rate hypothyroidism hypoparathyroidism hypocalcemia injury recurrent laryngeal nerve total occurrence rate group significantly lower group group differences statistically significant survival time months group months group months group survival time group significantly less groups difference statistically significant conclusions total resection unilateral gland combined isthmic resection conserves gland functionality reduces complications maintains survival time therefore worthy clinical application
study performed reveal factors associated dietary supplement use among japanese preschool children nationwide survey cross sectional internet survey conducted among mothers aged old preschool children registrants japanese social research company february questionnaires assessed dietary supplement use lifestyle eating habits children mothers eating awareness among mothers mothers sources health information study employed logistic regression analysis evaluate association dietary supplement use variables dietary supplements used children children used supplements tended older age less likely get cheerfully every morning likely skip breakfast eat frequently mothers used supplements children use supplements mothers level education household income associated supplement use among children likely mothers anxiety children health unhealthy eating habits striking effect supplement use among children however actual dietary balance daily rhythms child supplement users irregular unhealthy necessary give accurate information children dietary habits health address mothers anxiety
large number scholars involved producing english foreign language english second language efl esl materials hold gender roles representations either motivate motivate students learning foreign language english ever since day scholars pinpointed importance gender efl esl textbooks number studies carried uncover biases imbedded intentionally unintentionally different english textbooks taught world linked previous studies current study aimed investigating social gender identity defined via adjectives photos used world english series published cengage heinle publication end common adjectives used conversation section world english detected counted shown relevant tables using frequencies moreover photos extracted national geographic tested gender biases results study show world english tries show men women equally albeit instances biases found photos results study used syllabus designers materials developers efl esl teachers interested textbook analysis well gender biases
smiling enhances women facial attractiveness findings inconclusive men present study investigated effect smiling male facial attractiveness short long term prospective partners using east asian european samples experiment female participants rated male facial attractiveness facilitative effect smiling present judging long term partners absent short term partners pattern observed east asians well europeans experiment demonstrated smiling male faces engendered impression suitable long term partnership high ratings trustworthiness neutral faces produced impression suitable short term partnership high ratings masculinity discuss results terms opposing evolutionary strategies mate choice heritable benefit versus paternal investment
effects five towns river water pollution examined along lyna river southern watershed baltic sea northern poland relationships among spatially derived indicators urbanization environmental variables physicochemical microbiological data heterotrophic plate count degrees fecal coli obtained longitudinal river profiling examined use multivariate analyses principal component analysis factor analysis pca hierarchical cluster analysis hca recognized river channel environmental path links serial urban areas urban river continuum overall increasing trend nutrients indicator bacteria suburban headwaters urbanized sections river detected despite significant decrease towns concluded role multicity equally important single urban area predicting impacts man made pollutants river water quality
histomorphological histochemical studies conducted cardiac conduction system buffalo heart prenatal development foetuses ranging cvrl days cvrl days used study heart tissues fixed buffered neutral formalin bnf routinely processed paraffin sections thickness stained various stains study histomorphological histochemical details study revealed sinoatrial node subepicardial wedged junction anterior vena cava right atrium cvrl days foetus nodal purkinje type specialized cells observed sinoatrial node atrio ventricular node present base atrial septum front coronary sinus endocardium branch right bundle first noticed cvrl days buffalo foetus sinoatrial node right bundle branch showed intense reaction acid neutral mucopolysaccharides basic proteins age moderate strong sudanophilic reaction found purkinje fibers nodal cells sinoatrial node branch right bundle
paper explores interest policy makers encourage develop green economy particular focus government attempts engender shift mainstream building construction sector towards adopting green building methods techniques building sector focus endeavours engender shift towards greener ways working building due high contribution greenhouse gas emissions associated concerns enhanced global warming climate change paper outlines recent development national policy green building exemplified legislation code sustainable homes building regulations given rise particular set responses green building requirements favour technological solutions readily accommodated existing system critiquing developments draw upon socio technical sustainability transitions research one strand focused ways niche developments challenge disrupt existing regimes practice empirically research green building sector involved depth interviews range actors green building sector including architects building companies materials suppliers policy makers respondents within green building niche critical current legislation argue narrow conceptualisation fails adequately encourage recognise would consider green building forms contribute substantial reductions carbon emissions respect locally appropriate building methods elsevier ltd rights reserved
paper new implementation compact smart resistive sensor based microcontroller internal adcs proposed analysed solution based already existing system microcontroller simple sensor interface circuit working voltage divider consisting reference resistor resistive sensor connected parallel interference suppression capacitor measurement method based stimulation sensor interface circuit single square voltage pulse sampling resulting voltage resistive sensor proposed solution illustrated complete application compact smart resistive sensor used temperature measurements based bit atxmegaa microcontroller bit adc resistive sensor results experimental research confirm compact smart resistive sensor degrees resolution temperature measurement whole range changes measured temperatures polish academy sciences rights reserved
study aimed compare performance internal combustion engine fed blends biodiesel produced soybean diesel blends biodiesel produced beef tallow diesel performance evaluated terms power generated low loading conditions emission organic inorganic pollutants order analyse inorganic gases nox automatic analyser used organic emissions benzene toluene ethylbenzene xylene btex carried using gas chromatograph results indicate introduction two biodiesels fuel caused reduction btex emissions addition reduction proportional increase loading regime beef tallow biodiesels presented better results regarding emission soybean biodiesels use pure biodiesels also presented net reduction pollutant gas emissions without hindering engine generator performance
objetive describe incidence musculoskeletal injuries senior junior recreational spanish paddle tennis players methods subjects age play position sport level hypothesized injury risk factors sample composed active paddle tennis players men mean age participants asked injuries suffered paddle tennis career completed international physical activity questionnaire ipaq two groups made junior senior compare main determinants injury group results results showed specific joint lesions due paddle tennis located mainly elbow seniors juniors lower back seniors juniors knee seniors juniors conclusions elbow shown common region injury senior group junior group lower back region showed higher incidence main injury risk factors observed age body mass index laterality although relationships sufficiently strong high predictive value findings could help physiotherapists create preventive programmes focused mainly scaputohumeral joint lumbar pelvic motor control lower limb strength elsevier masson sas rights reserved
advancement internet computer network security brought serious concerns intrusion detection important topic network security framework address effectiveness efficiency problem traditional intrusion detection models present intrusion detection method based deep leaning deep belief network dbn constructed via stacked boltzmann machine model rbm selected firstly combining numeralization symbolic features numeric features normalization used processing network log features addition extreme learning machine elm applied learning process dbn compared traditional dbn experimental results nsl kdd dataset demonstrate intrusion detection based idbn double training speed compared dbn achieving reliable detection rate
objectives stress odontophobia represent major problem operators committed proper smooth conduct therapies simple verbal approach enough common solution make use medications present work evaluates virtual reality system allow stabilization patients cardiovascular parameters consequent management stress materials methods non dentophobic patients mean age years subjected tartar ablation without use video glasses unidexx one unidexx srl pomezia italy completion treatment patients pressure heart rate measured results conclusions statistically significant result obtained use combined audio video system audio music produce equally significant results preliminary study make possible observe use virtual reality system serves effectively stabilize even reduce cardiovascular factors related state stress studies needed confirm obtained results
background retention care challenging step along hiv care continuum many patients engage care achieve viral suppression care interruptions characterized moving care churn poor retention clinical consequences contributes new hiv transmissions predict prevent remains elusive study sought understand relationship individual structural level barriers poor retention persons living hiv aids atlanta methods administered survey interviews hiv infected patients continuously retained care years continuouslyretained patients recent gaps care unretained assessed individual level protective factors successful engagement self efficacy resilience perceived social support disclosure risk factors poor engagement substance use mental illness stigma structural systemic level barriers financial housing instability transportation food insecurity communication barriers incarceration history chi square mann whitney tests used compare populations results continuously retained unretained populations high rates prior viral suppression unretained patients virologically suppressed upon return care younger age crack cocaine use food insecurity financial instability housing instability phone number changes past year significantly likely present unretained population conclusions findings suggest need targeted risk assessment tools predict highest risk patients poor retention whereby public health interventions directed individuals
association air pollution bone health evaluated adolescents city tehran study essentially ecological vitamin deficiency among adolescents reported higher rates polluted areas non polluted areas additionally residence polluted areas associated lower levels bone alkaline phosphatase purpose aim study evaluate association ambient air pollution bone turnover adolescents compare prevalence vitamin deficiency polluted non polluted areas tehran methods cross sectional population based study conducted middle high school students girls boys tehran winter study period detailed daily data air pollution obtained archived data collected tehran air quality control company aqcc serum levels calcium phosphorus parathyroid hormone pth bone specific alkaline phosphatase vitamin osteocalcin cross linked ctelopeptide ctx total protein albumin creatinine obtained study group results vitamin deficiency prevalent polluted areas non polluted areas adjustment age sex residence polluted area showed statistically significant positive association vitamin deficiency statistically significant negative association bone turnover interestingly high calcium intake week protects effects air pollution bone turnover conclusions air pollution chief factor determining amount solar uvb reaches earth surface thus atmospheric pollution may play significant independent role development vitamin deficiency
exposure fine particulate matter associated mortality extent adverse impacts differs across various regions quantitative estimation health effects attributed china urgently required particularly largest population high air pollution levels based remote sensing derived grid population data estimated acute health effects china using exposure response function results suggest following proportion population exposed high concentrations increased consistently population exposed concentrations threshold defined world health organization rose number deaths associated exposure increased steadily larger numbers eastern region health effects decreased three pollution control scenarios estimated air pollution prevention control action plan appcap scenario appcap scenario appcap scenario indicates pollution control effectively reduce effects mortality
definition drug medicine substance exerts physiologic effect organism dermatology medications substances utilized daily basis topical treatments anesthetics micrographic surgery purpose section focus common substances specifically work utilized routine alternatives brief focuses cyclosporine utilization mechanism action efficacy dosage adverse effects special considerations alternatives treatment psoriasis
objectives due hormonal changes menopause women experience variety perimenopause postmenopause symptoms review examines various aspects nanostructured hormone therapy application treatments menopausal symptoms material methods excerpta medica database medical literature analysis retrieval system online web science google scholar searched basing preferred reporting items systematic reviews meta analyses guidelines seven eligible studies related papers satisfied initial search criteria extracted carefully reviewed clarify role nanomedicine maintaining postmenopausal women health results review seven eligible studies confirmed nanostructured hormone therapy safe effective method alleviation menopausal symptoms according existing studies nanostructured hormone therapy decreased mean daily frequency severity menopausal symptoms conclusion use transdermal nanoformulations hormone therapy relieve climacteric symptoms prevent postmenopausal symptoms
contemporary theories aetiology borderline personality disorder bpd take lifespan approach asserting inborn biological predisposition potentiated across development environmental risk factors review present critically evaluate evidence neurobiology bpd childhood adolescence compare evidence adult literature contextualise within neurodevelopmental framework systematic review conducted identify studies examining neurobiological genetic structural neuroimaging neurophysiological neuropsychological correlates bpd symptoms children adolescents aged years identified quality assessed narratively summarised studies published june similar findings adult populations twin studies indicated moderate high levels heritability bpd evidence gene environment interactions also consistent adult reports adolescents bpd demonstrated structural grey white matter alterations frontolimbic regions neuropsychological abnormalities reduced executive function disturbances social cognition findings suggest neurobiological abnormalities observed adult bpd may solely consequence chronic morbidity prolonged medication use also provide tentative support neurodevelopmental theories bpd demonstrating neurobiological markers may observed childhood onwards interact environmental factors increase risk bpd young populations prospective studies range repeated measures required elucidate temporal unfurling neurobiological features delineate complex pathways bpd
formal concept analysis mathematical tool applied successively diverse fields data mining conceptual modeling social networks software engineering semantic web cite one utter shortcoming formal concept analysis however large number formal concepts extracted even reasonably sized formal contexts overwhelming number key hindrance larger utilization technique fca overcome shortcoming extracting minimal coverage formal concepts could remedy even though task shown hard attracted attention many researchers paper introduce new gain function based approach called qualitycover extraction pertinent coverage formal context algorithm operates akin greedy approach relies assessment measure correlation selection formal concepts retained final coverage extensive experiments show qualitycover obtains encouraging results versus obtained pioneering approaches literature elsevier inc rights reserved
multiple sclerosis chronic degenerative condition heterogeneous symptoms unpredictable prognosis previous literature suggests patients experiences healthcare unsatisfactory primary care may play key role management people pwms however provision services pwms received little focus primary care literature study aimed explore perspectives experiences pwms healthcare professionals healthcare services semi structured interviews conducted pwms practice nurses general practitioners specialist nurses northern england october april participants purposively selected data analysed thematically using constant comparative analysis theoretical framework candidacy used interrogate data themes mapping onto national institute health care excellence nice guideline pwms interpreted symptoms leading candidacy care dictated help seeking pwms required additional support identifying symptoms due participants reported poor experiences care including poor access services poor continuity care poor interpersonal interactions perceptions limited person centredness pwms professionals identified related disability progression symptoms required responsive care relational continuity enabled pwms feel understood professionals holistically appraise symptoms progression conclusion continuity patient centredness care central positive healthcare experiences pwms professionals services need accessible ensure responsive effective management study provides unique findings role primary care pwms relationship findings nice guideline recommendations implications service delivery community
background objectiveadiponectin produced adipose cells considered anti inflammatory molecule contrast reactive protein crp identified hallmark systemic inflammation used risk marker cardiovascular disease cvd interest relationship two biomarkers oral health cvd risk material methodsthis investigation examined two molecules serum unstimulated whole saliva patients within acute myocardial infarction ami compared control subjects hypothesized differential response biomolecules resulting heart attack would affected body mass index oral health characteristics individuals resultssignificantly lower adiponectin levels observed serum patients ami serum adiponectin groups salivary adiponectin patients ami decreased increasing body mass index oral health significantly worse patients ami serum salivary adiponectin elevated better oral health control subjects serum crp levels increased patients ami regardless oral health serum salivary crp significantly elevated wave elevated patients conclusionsthese initial data provide evidence relating obesity oral health salivary serum analyte levels occur association cardiac events relationships described cvd risk periodontal disease additionally various systemic inflammatory biomarkers appear reflect cvd risk extent severity periodontitis findings indicated oral health obesity contribute altering levels salivary serum analytes association cardiac events potential serum salivary biomarkers could aid evaluating cvd risk requires knowledge regarding oral health individual would impact effectiveness biological measures
state art engineering education crucial research innovation according european union growth strategy paper contributes knowledge universities industry facilitate collaborative learning environments create efficient working methods group students accepted challenge industrial company examine robotic assembly products students built robot cell prototype company design department promote knowledge design robot manufacturing setting learning environment enabled knowledge creation significant learning outcomes university industrial company partners project motivated teachers collaborate across faculties university gave new insight formulation objectives type projects authors published elsevier
results large eddy simulations stably stratified atmospheric flow around isolated complex shaped tall building presented study focuses identification flow structures building wake high low froude number regimes qualitative comparison results available literature data existing theories presented addition flow structures identified earlier studies horseshoe recirculation eddy vortices analyze stationary disturbance akin mountain gravity wave complex vortex structure associated wave consisting multiple symmetric pairs vortices froude number appears principal parameter controlling structure wake waves vortex pattern
objective paper evaluate potential tank based rainwater harvesting systems source control methods mitigate runoff flow peaks urban areas water balance simulations rainwater tanks resolution time scale minute carried purpose using high resolution rainfall series toilet water demand data previous experimental campaign involved six experimental households southern italy simulations show significant reduction flow peak may obtained rainwater tanks depending tank size household water demand authors published elsevier ltd
purpose besides ventricular parameters design angular orientation prosthetic heart valve induce specific flow field aim study know inflow characteristics left ventricular model lvm investigating behavior tricuspid bioprosthetic mitral valves terms velocity profiles related valve aperture areas beginning diastole different conditions methods heart rates hrs established lvm mitral bioprosthesis diameter installed orientations rotated degrees experimental setup dimensional particle image velocimetry piv measurements simultaneous mitral valve area detection obtained samples results results velocity profiles immediately downstream mitral bioprostheses showed influence valve orientation moderate hrs although similar magnitude mean velocity vectors geometries open areas similar regardless valve orientation except valve beats per minute bpm valve bpm moreover similar percentages valve open area obtained regardless nominal diameters conclusions conclusion experimental setup piv measurements synchronized area detection useful tool knowing inflow characteristics lvm
computer programming offered universities intended prepare provide undergraduate students technical knowledge essential skills work real life software projects unfortunately developing countries programming hard faced insufficient infrastructures teaching staffs spite challenges undergraduate students never back increasingly developing software applications improving skills even without formal classes software intended use developer requires teamwork application software engineering methodology therefore concern learn programming development methodology apply ensure product quality paper investigates learn programming knowledge software quality conducted survey undergraduate students computer science university venda univen developers data collected analyzed qualitatively presented results show students consider online reuse codes new best method learn programming furthermore used development methodology mindful software quality
background well known whether left atrial enlargement associated left ventricular remodeling asian subjects preserved ejection fraction lvef therefore studied whether enlargement related ventricular remodeling hypertensive chinese elderly preserved lvef methods data hypertensive chinese elderly age years lvef consecutively included study results observed total patients increased size univariate analysis showed size positively related duration hypertension prevalence coronary heart disease atrial fibrillation interventricular septal thickness posterior wall thickness end diastolic end systolic diameter mass index right ventricular diameter aortic diameter meanwhile size inversely related lvef relative wall thickness multivariate regression analysis showed enlargement positively related duration hypertension diameter conclusions left atrial enlargement independently associated longer duration hypertension dilative remodeling hypertensive elderly preserved lvef enlargement early sign eccentric remodeling hypertensive elderly
study examined contribution phenotypic domains boldness meanness disinhibition triarchic conceptualization psychopathy patrick fowles krueger deficient aversive potentiated startle mixed gender sample undergraduates eyeblink responses noise probes recorded passive picture viewing task erotica neutral threat mutilation deficient threat neutral potentiation uniquely related increased boldness scores thus suggesting diminished defensive reaction aversive stimulation specifically linked charm social potency venturesomeness features psychopathy boldness features callousness coldheartedness cruelty traits meanness even though phenotypes theoretically share underlying low fear disposition findings provide evidence differential association distinct psychopathy components deficits defensive reactivity strongly support validity triarchic model psychopathy disentangling etiology personality disorder elsevier rights reserved
neuropeptide calcitonin gene related peptide cgrp key player migraine although migraine treated using cgrp antagonists act peripherally relevant sites cgrp action remain unknown address role cgrp within outside cns used cgrp induced light aversive behavior mice measure migraine associated photophobia peripheral intraperitoneal injection cgrp resulted light aversive behavior wild type mice similar aversion seen previously central intracerebroventricular injection phenotype also observed cbl mice although lesser degree variability intraperitoneal cgrp motility decreased dark similar motility changes intracerebroventricular cgrp addition intracerebroventricular cgrp general increase anxiety measured open field assay intraperitoneal cgrp importantly two clinically effective migraine drugs htb agonist sumatriptan cgrp blocking monoclonal antibody attenuated peripheral cgrp induced light aversion motility behaviors begin address mechanism peripheral cgrp action used transgenic cgrp sensitized mice elevated levels cgrp receptor hramp subunit nervous tissue nestin hramp surprisingly sensitivity low light seen intraperitoneal cgrp injection seen intracerebroventricular cgrp injection results suggest cgrp act periphery brain distinct mechanisms cgrp actions may transmitted cns via indirect sensitization peripheral nerves
objective evaluate effects osteoporosis induced glucocorticoid giop bone tissue rats experimental periodontitis design male wistar rats divided groups naive giop giop rats giop giop groups received dexamethasone intramuscularly week weeks following giop groups subjected ligature induced periodontitis naive group experienced manipulation days animals euthanized left maxillae collected macroscopic radiographic micro tomographic microscopic analysis alveolar bone loss abl blood samples collected determination bone specific alkaline phosphatase balp levels right femurs removed radiographic biomechanical analysis results caused abl reduced balp levels change architecture biomechanics femur compared naive giop cause abl significantly decreased alveolar bone mineral density abmd bone percentage trabecular thickness increased alveolar bone porosity significantly reduced balp serum levels well radiographic density young module femur compared naive greater abl group giop compared giop caused greater decrease abmd bone percentage increased bone porosity also presented significant reduction balp levels radiographic density young module femur compared conclusions giop potentiate destructive effects alveolar bone alter systemic bone loss promoting bone resorption reducing osteoblast activity elsevier ltd rights reserved
nondestructive testing strength materials structures based evaluation representative strength indices allow forecasting instant destruction occur flaws material complexities structure lead nonuniformities structural stressed strained strength states reduction testability objects necessity increasing strength margin criteria determining kind nonuniformity strength state structural materials formulated technique qualitative evaluation degree strength nonuniformity considered correlations different acoustic emission geometric strength characteristics obtained nondestructive method compared durability specimens
human nonverbal communication computing aims investigate people exploit nonverbal aspects communication coordinate activities social relationships nonverbal behavior plays important roles message production processing relational communication social interaction networks deception impression management emotional expression fundamental yet challenging research topic effectively analyze nonverbal communication computing motion analysis methods widely investigated employed paper introduce concept applications nonverbal communication computing also review motion analysis methods employed area include face tracking expression recognition body reconstruction group activity analysis addition also discuss open problems future directions area published elsevier
childhood eczema atopic dermatitis distressing disease associated pruritus sleep disturbance impaired quality life staphylococcus aureus isolation pathophysiology complex various seromarkers immunity involved investigated anti staphylococcal enterotoxin ige anti selected seromarkers regulatory treg helper antigen presenting cells apc associated clinical signs disease severity quality life disease severity assessed scoring atopic dermatitis scorad index quality life children dermatology life quality index cdlqi patients years old concentrations anti staphylococcus enterotoxin immunoglobulin anti sea anti seb selected treg apc chemokines skin hydration transepidermal water loss tewl measured patients forty patients median interquartile range age years recruited backward stepwise linear regression controlling age personal allergic rhinitis asthma blood markers showed serum anti seb level positively associated aureus epidermidis isolations objective scorad clinical signs cdlqi tnf cytokine positively associated objective scorad tgf treg cytokine negatively disease extent apc cytokine positively disease extent tewl apc cytokine negatively disease extent positively pruritus conclusions blood levels anti seb treg apc cytokines correlated various clinical signs systemic immunologic disease involving staphylococcus aureus cellular humoral cytokine chemokine pathophysiology
study focuses developing low cost power management system residential solar hydrogen power plants proposed power management system designed hybrid control system consisting microcontroller labview data acquisition card controllers boundaries power management providing practical solution hybrid power plants limitations proposed controller checks total energy demand hybrid power plant real time operates solar hydrogen energy based power plant local load implemented electronic control card monitors hybrid system operates related switches select proper energy source local load proposed real time management system also provides low cost power management residential power plants experimental results prove developed hybrid power management system easy implement suitable residential applications hydrogen energy publications llc published elsevier ltd rights reserved
indentation problem elastic perfectly plastic film rigid plane indenter flat end solved zeroth order ratio film thickness contact width frictionless contact contact width much larger film thickness explicit relation indentation force indentation depth obtained plastic range finite element results supported relationship ratio film thickness contact width less equal ratio elastic energy plastic energy indentation cycle found proportional film thickness inversely proportional plastic indentation depth elastic indentation multilayer structure rigid plane indenter flat end frictionless contact inverse effective contact modulus multilayer structure linearly depends thickness ratio layer structure thickness inverse contact modulus layer indentation bilayer structure non slip contact structure rigid substrate finite element results showed effective contact modulus indentation load occurrence plastic deformation increase decreasing layer thickness demonstrating constraint induced enhancement mechanical strength materials
known relationship cannabis use schizophrenia related symptoms however subject controversy involvement receptor ligands schizophrenia already revealed confirmed however still lack information concerning role receptors psychosislike effects mice studies needed aim present research study role receptor ligands symptoms typical schizophrenia provoked hyperlocomotion mice analogous positive psychosis like effects humans acute administration nmda receptor antagonist pharmacological model schizophrenia acute administration induced increase locomotor activity hyperactivity rodents measured actimeters revealed acute injection receptor agonist jwh dose range receptor antagonist dose range decreased locomotion mice acute injection jwh statistical significant influence locomotor activity mice however acute injection receptor ligands agonist antagonist jwh non effective dose non effective dose potentiated induced hyperactivity present findings confirmed endocannabinoid system via also via receptors may involved schizophrenia like responses including hyperlocomotion mice
present study operationally defined aggressive behavior males antisocial personality disorder aspd measured following acute intranasal oxytocin dosing international units placebo using well validated laboratory task human aggression point subtraction aggression paradigm psap psap provides participants concurrently available monetary earning operationally defined aggressive response options maintained fixed ratio schedules consequences shifts response rates interresponse time irt distributions observed aggressive response option following oxytocin doses relative placebo changes observed monetary reinforced responding however across participants direction magnitude changes aggressive responding systematically related dose trends observed psychometric physiological data oxytocin dosing aggressive behavior report knowledge first examine acute effects oxytocin population high risk violence forms antisocial behavior several limitations experimental design results cast study preliminary report strategies extensive future projects discussed
reuse software components either closed open source considered one important best practices software engineering since reduces development cost improves software quality however since reused components definition generic need customized integrated specific system useful since integration system specific integration effort non negligible increases maintenance costs especially one component needs integrated paper performs empirical study multi component integration context three successful open source distributions debian ubuntu freebsd distributions integrate thousands open source components operating system kernel deliver coherent software product millions users worldwide empirically identified seven major integration activities performed maintainers distributions documented activities performed maintainers evaluated refined identified activities input six maintainers three studied distributions documented activities provide common vocabulary component integration open source distributions outline roadmap future research software integration
given positive integers tinfinity exists exist results indicate limit paper completely solve problem showing lim infinity published elsevier
developed consensus best practice real life management patients overactive bladder oab onabotulinumtoxin onabot march interdisciplinary conference convened eleven panelists invited review literature present personal experience respond number questions propose onabot treatment decide inject patient summary findings meeting provided panelists review approval following statements agreed refractory oab defined based lack adherence first second line treatments oab regardless underlying cause onabot treatment proposed refractory oab patients provided willing perform intermittent catheterization needed treatment uroflowmetry post void residual evaluation needed rule voiding dysfunction urodynamics done cases complicated oab wet urinary tract infection ruled treated injection injection performed endoscopy room patient basis local anesthesia antibiotic prophylaxis initiated oral drugs first follow visit planned days treatment residual urine checked retreatment decided patients request symptoms worsen consensus document provides guide management refractory oab patients onabot real life number questions effectiveness onabot real life remain open
conveyor systems allow quick efficient transportation wide variety materials make popular material handling packaging industries many kinds conveying systems available used according various needs different industries adjustable speed drives used operation conveyors used number industries use adjustable electric drives number industrial applications typical adjustable speed drive consists induction motor power electronic converter cases motor speed commanded control system requires actual speed signal closing speed loop industrial applications speed sensors well sensorless solutions used due possibility current speed sensor noises maintenance economic aspects trend substitute speed sensors computational solutions comprehensive reviews sensorless drives show still persistent problems associated sensorless control needs new solutions asds advanced control approach foc method used modern industrial drives current stator controller integral part various foc systems classical foc solution hysteresis controllers generally used however pccs reported better properties system sensitivity inaccuracy changes motor equivalent circuit parameters another problem electrical drives almost foc systems sensitive inaccuracies therefore parameters estimated online robust structure control required real time implementation system important task even electric drives power converters
aging skin among common patient concerns facial plastic surgery practice ultraviolet induced damage expedites pace intrinsic aging resulting many visible signs aging rough skin texture pigmentation irregularities fine deep wrinkling inelasticity primary prevention environmental damage proper skin care use sunscreen critical great interest topically applied products reverse delay visible signs photoaging discuss common topically applied agents photoaging reviewing mechanisms supporting evidence
management water resources dry season major challenge associated rainwater harvesting rwh technology necessary given human suffering follows resulting conditions water scarcity study parameters dry season assessment defined terms water days nwd rainwater usage ratio simple socio technical operational strategy making use water level monitoring system proposed nwd reduction involves water level monitoring whereby daily water demand varies user cooperation based available water tank results study show nwd low achieved compared current value days considering investment additional roof catchments tank volume parameters useful analyzing type rooftop rwh system furthermore operational strategy made practical simplified incorporating easily visible understood guideline onto rwh system strategy replicable anywhere world consideration site specific conditions rainfall amounts roof sizes population
use set three resistive sensors based undoped multi walled carbon nanotubes doped multi walled carbon nanotubes doped multi walled carbon nanotubes study fungal infection strawberries inoculated rhizopus aspergillus section nigri apply tristimulus analysis using conductance variation sensors exposed infected strawberries distinguish uninfected strawberries strawberries infected rhizopus aspergillus section nigri obtain graphical representation providing tool simple fast detection identification fungal infection
background allermix survey conducted gain insights frequently diagnosed allergies worldwide use allergen immunotherapy ait clinical practice identify current clinical approaches management polyallergic patients methods survey conducted countries worldwide clinicians currently prescribing ait completed online questionnaire designed gather data daily clinical practice commonly diagnosed treated allergies among patients awareness adherence recommendations guidelines ait ait format choose prescribe management polyallergic patients results respondents considered clinical demonstration safety effectiveness quality standardization allergen extract key factors influencing choice ait formulation prescribe respondents reported managing polyallergic patients treated single allergen ait multiple allergen ait respondents aware latest ait practice guidelines awareness recent recommendations pharmaceutical manufacturers conclusion findings highlight need high quality ait products supported robust efficacy safety data address treatment habits allergy specialists real life clinical practice
facial emotion recognition fer thought key deficit domain autism spectrum disorder asd however extant literature based solely cross sectional studies thus little known even short term intra individual dynamics fer asd time present study sought examine trajectories fer asd youth weeks repeated measurement evaluate effects internalizing externalizing symptoms trajectories hierarchical linear modeling analyses revealed fer errors decreased time even particularly difficult stimuli moreover fer improvement enhanced internalizing symptoms attenuated externalizing symptoms implications models fer development reciprocal relations fer comorbidity intervention design planning discussed
although osteoarthritis traditionally regarded non inflammatory disease reports increasingly suggest inflammatory least certain patients patients often exhibit inflammatory infiltration synovial membranes macrophages cells mast cells cells plasma cells natural killer cells dendritic cells granulocytes etc although previous reviews summarized knowledge inflammation pathogenesis far know report review current understanding cells especially cell subtype biology review highlights current understanding role cells pathogenesis attention cells cells cells cells cells regulatory cells follicular helper cells cytotoxic cells memory cells even unconventional cells gamma delta cells cluster differentiation restricted cells findings highlight importance cells development progression suggest new therapeutic approaches patients based manipulation cell responses
finding better method acute myeloid leukaemia aml induction designed prospective clinical trial find effective regimen least toxicity induction therapy aml hence examined different accepted doses daunorubicin outcomes total patients included study fifty five patients received daunorubicin arm infusion days remaining received arm infusion days continuous infusion day cytosine arabinozide days given groups complete remission rate group group one year overall survival standard error arm arm median follow time months respectively one year disease free survival arm arm complete remission overall survival disease free survival statistically groups toxicity safety profile similar two groups need transfusion higher arm febrile neutropenia days antibiotics consumption invasive fungal infection prevalence show difference mean transfused packed cells platelets rate higher group received higher dose daunorubicin considering results found daunorubicin would rational effective lower toxicity induction therapy aml patients least scheduled trial copyright john wiley sons ltd
applying pesticides crops one causes water pollution surface runoff chlorpyrifos trifluralin chlorothalonil used respectively insecticide herbicide fungicide crop plants widely explore effects three pesticides aquatic organisms superoxide dismutase sod glutathione transferase gst activities determined exposure magna ages several low concentrations chlorpyrifos trifluralin chlorothalonil respectively main reproductive parameters including first pregnancy time first brood time number first brood total fecundity exposures concentrations pesticides described also measured results showed activities gst increased lower concentrations decreased higher concentrations exposure three pesticides respectively activities sod showed changes exposure time prolonged activities gst decreased activities sod increased exposure first pregnancy time first brood time delayed number first brood total fecundity per female decreased increasing concentrations results corroborated gst activity sensitive pesticides sod activity significant relationship total fecundity pesticides dose gst activity exposure total fecundity exposure
individuals schizophrenia display notable deficits social functioning research indicates neural connectivity within default mode network dmn related social cognition social functioning healthy clinical populations however association dmn connectivity social cognition social functioning studied schizophrenia present study authors used resting state neuroimaging data evaluate connectivity main dmn hubs medial prefrontal cortex mpfc posterior cingulate cortex anterior precuneus ppc individuals schizophrenia controls authors also examined whether dmn connectivity associated social functioning via social attainment measured specific levels functioning scale social competence measured social skills performance assessment social cognition mediates association dmn connectivity measures social functioning results revealed dmn connectivity differ individuals schizophrenia controls however connectivity mpfc pcc hubs significantly associated social competence social attainment individuals schizophrenia controls reflected significant group connectivity interaction social cognition mediate association dmn connectivity social functioning individuals schizophrenia findings suggest fronto parietal dmn connectivity particular may differentially associated social functioning schizophrenia controls result dmn connectivity may used neuroimaging marker monitor treatment response potential target interventions aim enhance social functioning schizophrenia
disposal olive mill wastewaters omw shallow unprotected evaporation ponds common low cost management practice followed mediterranean countries far fate potential soil pollutants areas located near evaporation ponds adequately documented study investigates extent long term disposal omw evaporation ponds affect soil properties area located outside evaporation pond assesses fate pollution loads omw four soil profiles situated outside around slope side disposal area excavated results showed considerable changes concentration soil phenols site soil profiles due subsurface transport omw addition excessive concentrations phenols recorded liquid samples taken inside bottom soil profiles concluded unprotected evaporation ponds located light texture soils pose serious threat favour soil water pollution
aim study determine effect egg water loss storage incubation hatch rates heavy type broad breasted white big turkeys turkey hens started laying eggs weeks age weeks laying season eggs selected randomly divided groups eggs groups eggs stored days incubation beginning end storage period days incubation eggs weighed determine percent water loss relative egg weight four incubation cycles eggs performed storage period total incubation cycles carried weeks laying season egg storage periods following parameters determined egg fertilization dead embryos unhatched eggs hatchability results fertilized eggs percentages dead embryos unhatched poults physical defects abnormal position determined hatchery waste incubation cycle egg water loss varied throughout storage reached total egg weight days days days days days storage egg water loss day day incubation period reached lower values noted days storage egg water loss storage resulted high rate early embryonic mortality low hatch rate weeks laying season egg water loss day incubation period similar weeks laying season lower week hatchability turkey eggs lowest weeks laying season low water loss incubation contributed high rate late embryonic mortality high water loss egg storage accompanied lower water loss incubation water loss monitored storage days incubation evaluate water metabolism hatching eggs
method chemistry tabulation combined presumed probability density function pdf applied simulate piloted premixed jet burner flames high karlovitz number using large eddy simulation thermo chemistry states tabulated combination auto ignition extended auto ignition model evaluate predictive capability proposed tabulation method represent thermo chemistry states condition different fresh gases temperature priori study conducted performing idealised transient one dimensional premixed flame simulations presumed pdf used involve interaction turbulence flame beta pdf model reaction progress variable distribution two presumed pdf models dirichlet distribution independent beta distribution respectively applied representing interaction two mixture fractions associated three inlet streams comparisons statistical results show two presumed pdf models two mixture fractions capable predicting temperature major species profiles however shown significant effect predictions intermediate species analysis thermo chemical state space representation sub grid scale sgs combustion model performed comparing correlations carbon monoxide mass fraction temperature sgs combustion model based proposed chemistry tabulation reasonably capture peak value change trend intermediate species aspects regarding model extensions adequately predict peak location intermediate species discussed
acne common skin disease involves seborrheic area face results obstruction hair follicles followed inflammation careful face washing helps improve prevent acne however intensive washing risk inducing skin barrier impairment dry skin especially sensitive skin hypothesized skin care combining mild skin cleansing intensive moisturizing combination skin care may effective care acne subjects dry skin sensitive skin developed combination skin care weakly acidic foaming facial skin cleanser based mild detergent aqueous lotion eucalyptus extract moisturizing gel containing pseudo ceramide eucalyptus extract optimize ideal facial skin care system mild acne sensitive skin performed week clinical trial post adolescent japanese women mild acne dry sensitive skin acne significantly decreased trial accompanied improvement dry skin significantly increased endogenous ceramide level stratum corneum elongated alkyl chain length non hydroxy acyl sphingosine type ceramide adverse events due test samples observed based diagnosis dermatologist subjects found combination skin care useful slightly useful based findings combined use facial skin cleanser moisturizers safe effective care acne post adolescent japanese women sensitive skin
attention deficit hyperactivity disorder adhd commonly associated disordered disturbed sleep relationships adhd sleep problems psychiatric comorbidities medications complex multidirectional evidence published studies comparing sleep individuals adhd typically developing controls concordant associations adhd hypopnea apnea peripheral limb movements sleep nocturnal motricity polysomnographic studies increased sleep onset latency shorter sleep time actigraphic studies bedtime resistance difficulty morning awakenings sleep onset difficulties sleep disordered breathing night awakenings daytime sleepiness subjective studies adhd also frequently coincident sleep disorders obstructive sleep apnea peripheral limb movement disorder restless legs syndrome circadian rhythm sleep disorders psychostimulant medications associated disrupted disturbed sleep also paradoxically calm patients adhd sleep alleviating symptoms long acting formulations may insufficient duration action leading symptom rebound bedtime current guidelines recommend assessment sleep disturbance evaluation adhd initiation pharmacotherapy healthy sleep practices first line option addressing sleep problems review aims provide comprehensive overview relationships adhd sleep presents conceptual model modes interaction adhd may cause sleep problems intrinsic feature disorder sleep problems may cause mimic adhd adhd sleep problems may interact reciprocal causation possible involvement comorbidity adhd sleep problems may share common underlying neurological etiology
background historically marital status associated lower mortality transitions marriage generally accompanied improved health status conversely divorce associated increased mortality possibly mediated changes health behaviors methods study uses data prospective cohort postmenopausal women participating women health initiative observational study whi examine relationship marital transition health indicators blood pressure waist circumference body mass index bmi well health behaviors diet pattern alcohol use physical activity smoking sample relatively healthy employed women linear logistic regression modeling used test associations controlling confounding factors results women transitions marriage marriage like relationship menopause associated greater increase bmi beta confidence interval alcohol intake beta relative remaining unmarried divorce separation associated reduction bmi waist circumference changes accompanied improvements diet quality beta physical activity beta relative women remained married conclusion contrary earlier literature findings among well educated predominantly non hispanic white women suggest marital transitions menopause accompanied modifiable health outcomes behaviors favorable women experiencing divorce separation entering new marriage
ochratoxin ota mycotoxin fungal toxin contaminates multiple foodstuffs worldwide affected commodities include oats wheat maize barley raisins dried vine fruits wine beer coffee cocoa although ota shown cause kidney disease including kidney cancer multiple animal species impact dietary ota human health global perspective less clear several epidemiological studies suggest association ota exposure human kidney disease evidence causality limited nonetheless ota common many foodstuffs may play role kidney disease consider important improve body evidence surrounding ota adverse effects humans well human dietary exposures different parts world especially true light increasing type diabetes obesity prevalence worldwide conditions frequently lead chronic kidney disease ckd may synergize dietary ota exposure increase ckd risk elsevier ltd rights reserved
context need children palliative care cpc globally unknown understand scope need advocate meet accurate estimates needed objectives objective study create accurate global estimate worldwide need cpc based representative sample countries regions world world bank income groups methods work builds previously published methods developed international children palliative care network united nations children fund world health organization tested three african countries study used cross sectional design quantitative data obtained primary secondary data sources estimation need used prevalence data institute health metrics evaluation mortality data world health organization specific diseases known require cpc joint united nations programme hiv aids unaids data hiv prevalence representative data analyzed countries representing world population results findings show estimated need cpc ranged almost per children zimbabwe slightly per united kingdom overall among million conditions benefit annually palliative care approach eight million need specialized cpc worldwide conclusion estimation need cpc critical step meeting needs children life threatening conditions provides sound platform advocate closure unacceptably wide gaps coverage american academy hospice palliative medicine published elsevier inc rights reserved
ontology based data access obda generalizes query answering relational databases allows query database using language ontology abstracting actual relations database obda sometimes realized compiling information ontology query database resulting query answered using classical database techniques paper consider temporal version obda propose generic temporal query language combines linear temporal logic queries ontologies language well suited expressing temporal properties dynamic systems useful context aware applications need detect specific situations show atemporal queries rewritable sense described corresponding temporal queries also rewritable answer temporal database present three approaches answering resulting queries elsevier rights reserved
single image super resolution great importance computer vision various methods learning methods successfully developed recent years despite demonstrated success natural images less research focuses infrared images paper present transformed self similarity based super resolution method without learning priors restore high resolution infrared images low resolution ones exploit appearance similarity dense error region covariances use detected cues guide patch search process also add scale cue consider local scale variations present compositional framework simultaneously accommodate four different cues experimental results demonstrate method performs better previous methods restores pleasant results high evaluate scores show effectiveness robustness method infrared images elsevier rights reserved
paper reports design development reconfigurable point data parallel constant geometry fast fourier transform fft architectures based network chip noc paradigm twiddle factor multiplications realized using pipelined cordic rotators proposed architecture order ensure high throughput mapping fft functions cores done considering proposed signal flow graph sfg fft architecture helps optimizing design network components routers network interfaces reducing latency fft computation proposed input size aware architecture withstand faults processing elements pes accomplish entire fft computation using one well mapped onto mesh based noc proposed architectures could achieve reduction latency compared several existing fft architectures noc hardware realization network components proposed architectures done using xilinx kintex family field programmable gate array fpga device maximum operating frequency proposed architecture found mhz meets timing specifications several application standards dvb dab uwb addition fpga prototype proposed architectures also synthesized asic design flow obtain area power results elsevier rights reserved
computational study thermodynamics proton hydride transfer ammonium borohydride six phosphonium borohydride intramolecular intermolecular frustrated lewis pairs flps probed gain insight whether intramolecular intermolecular amine containing flps preferred phosphine containing flps flp catalyzed hydrogenation reactions hydride proton transfer intramolecular ammonium borohydrides average kcal mol kcal mol units respectively less likely intramolecular phosphonium borohydrides using thermodynamic quantities hydride proton transfer eight probe substrates intramolecular phosphonium borohydrides found thermodynamically preferred intramolecular ammonium borohydrides catalytic hydrogenation reactions
hybridization newly proposed concept solar thermal energy provides portion required thermal input instead fossil fuels natural gases storage intermittency concerns regarding solar energy make hybridization viable solution increase renewable energy share power generation maisotsenko gas turbine cycle recently proposed humid air turbine cycle implemented bottoming cycle topping gas turbine cycle maisotsenko bottoming cycle paper maisotsenko bottoming cycle power plant hybridization thoroughly investigated using heliostat field collector first thermo economic optimization carried hybrid maisotsenko bottoming cycle power plant united arab emirates furthermore optimization results maisotsenko bottoming cycle evaluated acquired results hybrid air bottoming cycle conventional combined cycle finally different levels hybridization considered already existing non hybrid maisotsenko bottoming cycle power plant applying different thermo economic assessment methods comparative analyses indicate maisotsenko bottoming cycle economical alternative bottoming cycle implementation compared investigated configurations optimum levelized cost electricity elsevier ltd rights reserved
objective main goal controlled study compare presence depressive symptoms disorders men receiving combination androgen deprivation therapy radiation therapy adt rth men receiving rth method total men nonmetastatic prostate cancer formed two groups adt rth rth adt rth group subdivided men received long term adt short term adt participants assessed prior adt initiation seven additional times period months using semistructured interviews self report scales results prevalence depressive disorders ranged study period introduction adt associated increases depressive symptoms measures differences significant likewise withdrawal adt associated consistent decreases depressive symptoms none differences significant small sample size may limited statistical power detect differences however calculations effect sizes revealed small magnitude conclusions knowledge first controlled study investigated possible role adt development depression using prostate cancer patients receiving adt controls overall appears adt represent major risk factor depression good news patients receiving treatment already adapt many side effects
background actual connectivity populations freshwater organisms largely determined species biology also influenced many area site specific factors water pollution habitat fragmentation therefore prediction effective gene flow even well studied organisms difficult amphipod crustacean gammarus fossarum key invertebrate freshwater ecosystems contains many cryptic species one species broadly distributed fossarum clade type study tested factors driving genetic structure fossarum clade human impacted landscape local regional scales determine population structure analyzed mitochondrial cytochrome oxidase gene specimens sampling sites microsatellite loci specimens ten sites results detected strong overall genetic differentiation populations regional local scales independent marker systems often even within kilometers interestingly observed weak correlation genetic distances geographic distances catchment boundaries testing factors explaining observed population structure revealed mostly colonization history influenced structure rather chosen environmental factors whereas number stream barriers explain population differentiation large water reservoirs catchment likely act dispersal barriers conclusions showed populations gammarus fossarum clade strongly isolated even local scales human impacted region observed genetic structure best explained effects random genetic drift acting independently isolated populations historical colonization events genetic drift isolated populations probably enhanced anthropogenic impacts fossarum sensitive many anthropogenic stressors findings highlight importance small scale genetic studies determine barriers restricting gene flow prevent loss genetic diversity maintain intact freshwater ecosystems
concrete dam construction process real world circumstances concrete production schedules rarely executed planned due occurrence various unpredictable production system faults greatly influence rapid succession quality quantity concrete placement therefore identifying faults beforehand determining critical faults essential construction management guarantee harmonious rapid operations dam construction process construction simulation technology proven effective approach predicting concrete dam construction process performance project schedules however existing simulation models currently consider adverse influence concrete production system faults paper intended determine impact production system faults concrete placement duration monthly placement strength mechanical placement strength analysis fault response mechanism system carried fault response model proposed taking typical concrete dam project case study mathematical model probability statistics proposed clarify occurrence law faults production system random numbers subjected fault probability distribution generated represent whether fault occurred results fed back placement simulation module determine reasonable placement scheme addition sensitivity analysis carried results prove three kinds production system faults namely broken conveyor belts broken stone grooves pipe blockages significantly impact placement progress quality study primary contribution provide useful approach elaborate concrete dam construction process simulations well reference reasonable management production systems preventive measures
numerical model experimental validation compound parabolic concentrators cpc heat generation presented work previous model developed carefully revised modified order generalize mathematical model consists one dimensional numerical model describe thermal fluid dynamic behavior cpc governing equations continuity momentum energy fluid flow inside cpc absorber tube together energy equation absorber tube wall cover insulation reflector thermal analysis solar concentrator solved iteratively individually manner suitable reliable numerical strategy numerical convergence prototype cpc used evaluate validate numerical model consisted cylindrical absorber real concentration ratio acceptance angle aperture area measurement uncertainty analysis carried mean deviation model experimental data thermal efficiency increment temperature degrees pressure drop according results good correlation obtained numerical experimental results elsevier ltd rights reserved
present research examined association mediterranean diet adherence physical activity self esteem five components health related quality life data collected adolescents attending one five schools granada spain using cluster randomised design participants completed questionnaires mediterranean diet adherence physical activity self esteem health related quality life hrqol models constructed identify associations mediterranean diet adherence physical activity self esteem mediational analysis using bootstrapped confidence intervals examined possible mediation five components hrqol mediterranean diet adherence physical activity engagement associated four components hrqol positive physical wellbeing psychological wellbeing family relationships autonomy support perceptions school environment lifestyle behaviours positively associated self esteem relationships mediated positive psychological wellbeing perceptions school environment physical wellbeing also mediator relationship physical activity self esteem conclusion interventions promoting mediterranean diets physical activity adolescents may facilitate improvements self esteem addition wider health benefits previously identified approaches within interventions targeting improvements physical wellbeing psychological wellbeing positive perceptions school environment may improve efficacy
descriptive cross sectional study aimed evaluate specific factors influence sex lives psychiatric patients study sample consisted patients received care psychiatry department university hospital data collected using questionnaire developed according information available literature arizona sexual experience scale mean age patients study years additionally patients female male diagnostic composition sample patients schizophrenia bipolar disorder depression anxiety disorder half patients expressed reduced sex drive compared predisease condition patients claimed treatment contributed reduced sexual drive moreover patients expressed knowledge sexually transmitted diseases utilizing arizona sexual experience scale sexual dysfunction observed patients incidence sexual dysfunction people diagnosed schizophrenia found besignificantly higher patients diagnosis groups
gait modifications often proposed reduce average loading rate avlr running many modifications may reduce avlr little work investigated secondary gait changes thirty two rearfoot runners years week ran self selected speed instrumented treadmill mechanics calculated via real time data acquisition real time visual feedback provided randomized order cue forefoot strike ffs minimum decrease step length minimum reduction avlr avlr reduced ffs mean difference shortened step length cues reduce avlr ffs shortened step length cues reduce avlr reduced eccentric knee joint work per however ffs cues reduce avlr also increased eccentric ankle joint work per potentially injurious secondary effects associated ffs cues reduce avlr may undermine clinical utility alternatively shortened step length resulted small reductions avlr without potentially injurious secondary effects
sea level rise expected cause saltwater intrusion tidal freshwater wetlands resulting changes soil environment would likely cause shifts plant microbial communities alter ecosystem functions simulate saltwater intrusion constructed solar powered automated irrigation system system consisted holding tanks filled freshwater artificial brackish water high tide low tide water gravity fed solenoid valves metered plot system controlled open source microcontroller platform built shelf electronics cost porewater salinity near surface soils plots receiving brackish water increased freshwater oligohaline levels within one month operation maintained throughout first summer operation porewater manipulation led changes plant community exchanges carbon dioxide methane marsh atmosphere system proven reliable way manipulating wetland salinity studying changes physicochemical environment modifications could used manipulate nutrient loads hydrology sediment supply wetland systems
algorithmic music composition concerned generation music algorithms using natural language text basis generation opens interesting ideas research identified three strategies mapping text music using letters using vowels using vowels conjunction word part speech pos third approach best achieved full parse tree since helps identifying probable pos tag using text input applying strategies derive sequence notes pitches well rhythm note durations punctuation symbols input text mapped rest achieve greater flexibility composition instead directly mapping concrete notes use relativized note indices combine scale key octave parameters determine actual note music composition library implemented wolfram mathematica popular symbolic computation environment parsing input text use link make call outs apache opennlp library paper describe strategies detail suggest possible areas future work
background past scholarly efforts describe measure stigma surrounding suicide largely viewed suicide stigma perspective general public aims spirit community based participatory research cbpr current study brought together diverse stakeholder team qualitatively investigate suicide stigma experienced intimately affected suicide method seven focus groups conducted suicide attempt survivors family members died suicide suicide loss therapists results themes derived stereotypes prejudice discrimination people attempted suicide seen attention seeking selfish incompetent emotionally weak immoral participants described personal experiences prejudice discrimination including health professionals conclusion participants experienced public stigma self stigma label avoidance analyses reveal stigma suicide shares similarities stereotypes mental illness also includes important differences attempt survivors may subject double stigma impedes recovery access care
study aimed test association perceived stress problematic social networking site sns usage figure whether psychological resilience moderated relationship perceived stress scale connor davidson resilience scale facebook intrusion questionnaire administered chinese college students results showed perceived stress positively associated problematic sns usage psychological resilience negatively related problematic sns usage psychological resilience moderated relationship perceived stress problematic sns usage specifically relationship perceived stress problematic sns usage statistically significant students lower level psychological resilience significant association found higher level psychological resilience findings emphasize importance enhancing psychological resilience decrease likelihood college students experience higher level stress using sns problematically elsevier ltd rights reserved
endothelial dysfunction inflammation key mechanisms vascular disease hypothesised heterogeneity monocyte subpopulations may related development vascular dysfunction coronary artery disease cad therefore examined relationships monocyte subsets classical mon intermediate mon nonclassical mon endothelial function risk factor profiles patients cad undergoing coronary artery bypass grafting allowed direct nitric oxide bioavailability assessment using isometric tension studies vivo acetylcholine ach sodium nitropruside snp dependent segments internal mammary arteries expression antigens activation markers determined peripheral blood mononuclear cells using flow cytometry patients high nonclassical low classical monocytes presented impaired endothe lial function high frequency nonclassical monocytes associated increased vascular superoxide production furthermore endothelial dysfunction associated higher expression activation marker cdc selectively monocytes nonclassical classical monocyte frequencies remained independent predictors endothelial dysfunction major risk factors atherosclerosis taken account beta beta respectively summary data indicate nonclassical monocytes associated advanced vascular dysfunction measured bioavailability vascular reactive oxygen species production
proteomic changes described many neurodegenerative diseases including alzheimer disease however early events onset pathology yet fully elucidated cell model system lans neuroblastoma cells incubated short time recombinant form beta utilized proteins extracted cells subjected shotgun proteomics analysis ltq orbitrap followed label free quantitation bioinformatics tools found significant found regulated related cytoskeletal dynamics rho related membrane related processes significant regulated proteins hnrnp related particular hnrnps involved ribosomal biogenesis splicing regulated latter processes stood highlighted ubiquitously highest significance results every analysis furthermore findings revealed regulation every stage splicing process regulation every subunit spliceosome dysregulation spliceosome also confirmed using western blot conclusion data suggest dysregulation proteins processes identified early events pathogenesis following beta accumulation
postharvest pathogen penicillium digitatum causes green mold decay citrus fruit resulting severe economic losses explore possible factors involved fungal pathogenesis phenotypic characterization budding yeast fus kiss mitogen activated protein map kinase homolog carried digitatum map kinase coding gene designated pdmpkb functionally inactivated via homologous recombination fungal strain delta pdmpkb carrying pdmpkb deletion demonstrated altered gene expression profiles reduced growth conidiogenesis elevated resistance osmotic stress failed induce green mold decay citrus fruit delta pdmpkb resistant cacl nacl sorbitol progenitor strain indicating negative regulatory function pdmpkb osmotic stress adaptation fungal infection assays citrus fruit revealed delta pdmpkb proliferated poorly within host tissues induced water soaking lesions failed break host cuticle layers thus failed produce aerial hyphae conidia introduction functional copy pdmpkb null mutant restored defective phenotypes transcriptome analysis revealed inactivation pdmpkb impacted expression genes associated cell wall degrading enzyme activities carbohydrate amino acid metabolisms conidial formation numerous metabolic processes results define pivotal roles pdmpkb mediated signaling pathway developmental pathological functions citrus postharvest pathogen digitatum elsevier rights reserved
influence calendaring process nonwoven geotextiles water permeability normal planes including influence different loads well pore characteristics investigated two different methods studied methods pore characteristics differ obtaining different pore parameters two groups samples produced whereas first group bonded needle punching second group needle punched samples taken first group additionally bonded calendaring mass per unit area groups range increasing next sample within groups calendaring process decrease water permeability geotextile also decreases interval geotextile water permeability change due applied pressure calendared geotextiles controlled predictable compressibility respectively structure significantly change practical application
study investigated specific emotional lexicons narratives created persons diagnosed antisocial personality disorder aspd test hypothesis individuals aspd exhibit deficiencies emotional language study participants consisted prison inmates aspd prison inmates without aspd men without antisocial tendencies described situations involving love hate anxiety depicted photographs lexical choices made narratives analyzed comparison three groups revealed differences emotional narratives inmates aspd inmates without aspd control group although narratives individuals aspd included words describing emotions higher levels emotional intensity valence words inappropriate linguistic characteristics narratives associated high levels psychopathy low emotional reactivity
objective topical oxygen devices food drug administration fda cleared following indications use various etiologies skin ulcerations due diabetes venous stasis postsurgical infections gangrenous lesions decubitus ulcers amputations infected stumps skin grafts burns frostbite goal study understand impact topical oxygen therapy tot patient outcomes including amputation healing rates approach retrospective chart review included records collected january july male female patients ranging age years years wounds least treated least one separate modality treatment tot treated tot minimum weeks compliance fda approved indications records wounds longer treated tot results study tot associated overall rate reduction chronic wound size wounds healing overall amputation rate wounds study innovation knowledge retrospective chart review represents one largest data sets total wounds collected one longest time periods years evaluate patient outcomes following tot conclusion study revealed healing amputation rates similar reported controlled clinical studies using tot treat chronic wounds
background purpose study aims study factors affect stamina elderly patients trospium treatment methods carry experiment men women older years average age years taking trospium months selected questionnaire survey demographic social status financial statement analysis academic certificates overactive bladder questionnaire short form medical outcomes study short form questionnaires bladder diaries uroflowmetry used studies adherence treatment results average time reaching day trospium treatment free period compliance survival rate days percentage patients remained compliant months year respectively according data percentage highly educated married city residents aware nature disease significantly higher cohort consistent patients yet percentage caffeine abusers lower cohort percentage income spent trospium purchase lower income payment level medical expenses higher respectively compared cohorts analysis regressive models changes squared percentage income trospium costs confirmed hypothesis impact factors treatment compliance cohort consistent patients average number points role physical social functioning role emotional mental health values describe health impact quality life turned significantly higher severe incontinence symptoms overactive bladder prevailed among patients cohort also associated high treatment efficacy significantly lower number side effects conclusion high trospium treatment compliance among elderly men women determined several uneven demographic social economic medical factors copyright asia pacific league clinical gerontology geriatrics published elsevier taiwan llc open access article license http creativecommons org licenses
factor xii mysterious plasma protein without clear physiologic function identified clotting factor clear role hemostasis however fxii also contributes production bradykinin short lived inflammatory peptide growing body mechanistic research animal models indicates fxii contributes thrombotic disease triggering excessive coagulation fxii evolutionarily conserved suggesting molecule physiologic function leads intriguing questions fxii really even real clotting factor groundbreaking discovery role fxii thrombotic disease many studies investigated biochemical properties fxii activators review highlight several biochemical studies reveal much natural behavior fxii basis findings possible draft conceptual model explain fxii reacts surface materials discuss model applies activities fxii natural environment two tentative physiologic functions fxii operate exclusively maintenance thrombus stability local regulation vascular permeability either natural functions may explain evolutionary development maintenance fxii
grazed dairy pastures largest source nitrate leaching nitrous oxide emissions urine excreted animals additional application urine patches fertilizer may increase losses identification urine patches could reduce losses grazed pastures efficient fertilizer application improved fertilizer use efficiency nue aim study determine remote sensing using light detection ranging lidar technology could accurately identify urine patches grazed pastures based height variation grass canopy close proximity synthetic cow urine applied two blocks well established pasture canterbury new zealand recent exposure grazing animals fertilization urine patches scanned weekly five weeks lidar based contour maps pasture shown accurately detect asymmetric urine patches well calculate percent area urine based high early one week simulated grazing event authors published elsevier
objective explore effects five element music therapy elderly patients seasonal affective disorder chinese nursing home methods patients recruited shijingshan district nursing home beijing china randomly assigned two groups treatment group control group participants group patients received music therapy week week period music therapy involved four phases introduction activities listening chinese five element music concluding phase participants control group listen five element music study consisted two parts qualitative study used focus groups understand feelings patients seasonal affective disorder quantitative study involved administration self rating depression scale sds hamilton depression scale hamd treatment results qualitative analysis results strength derived five element group music therapy emotional adjustment five element group music therapy reduce patients psychological distress let feel inner peace enhance life satisfaction significant difference sds hamd scores found two groups prior treatment treatment mean sds score control group treatment group score hamd score control group treatment group score following weeks music therapy sds hamd scores treatment group significantly lower control group conclusion five element music therapy alleviated symptoms seasonal affective disorder elderly patients jtcm rights reserved
long horizon lengths moving horizon estimation desirable reach performance limits full information estimator however conventional mhe technique suffers number deficiencies respect first problem complexity scales least linearly horizon length selected restrains selecting long horizons computational limitations present second monitoring constraint activity inactivity results conducting redundant constrained minimizations even constraints active study develop multiple window moving horizon estimation strategy mhe exploits constraint inactivity reduce problem size long horizon estimation problems arrival cost approximated using unconstrained full information estimator arrival cost guarantee stability technique new horizon length selection criterion developed based sensitivity remote states time development terms general causal descriptor systems includes standard state space representation special case potential new estimation algorithm demonstrated example showing significant reduction computation time numerical errors compared conventional mhe elsevier ltd rights reserved
privacy software quality closely related security main difference security properties aim protection assets crucial considered system privacy aims protection personal data processed system identification privacy protection needs complex systems hard error prone task stakeholders whose personal data processed might overlooked sensitivity need protection personal data might underestimated later personal data needs protect identified development process expensive fix issues needed changes system often affect many functionalities paper present systematic method identify privacy needs software system based set functional requirements extending problem based privacy analysis propan method method tool supported automated possible reduce effort spent privacy analysis especially important considering complex systems contribution paper semi automatic method identify relevant privacy requirements software based functional requirements considered privacy requirements address dimensions privacy relevant software development method solely based functional requirements system enable users method identify privacy protection needs addressed software early stage development initial evaluation method show applicability small electronic health system scenario
background increased spiritual well related quality life qol patients heart failure however consistent deliberate integration spirituality patient care received limited attention objective aim study evaluate feasibility acceptability preliminary evidence regarding efficacy resource sparing psychospiritual intervention improve qol patients methods week mail based intervention addressing spirituality stress coping adjusting illness developed tested using mixed methods group pretest posttest pilot study design convenience sample patients completed prestudy poststudy questionnaires including kansas city cardiomyopathy questionnaire patient health questionnaire meaning life questionnaire functional assessment chronic illness therapy spiritual research staff conducted semistructured interviews program completers interviews coded analyzed using conventional content analysis results participants male mean age years completed baseline data collection average intervention modules poststudy questionnaires participants rated modules least moderately helpful qualitative themes suggested patients found intervention acceptable beneficial participants believed spirituality continue included although disagreed extent religion remain participants completed intervention reported evidence suggesting increased qol kansas city cardiomyopathy questionnaire effect size decreased depressive symptoms patient health questionnaire less searching meaning meaning life questionnaire conclusions results indicate module based program integrating spirituality psychosocial coping strategies feasible acceptable may improve qol preliminary study suggests clinicians open issues spirituality may relate qol patients future research test revised intervention
software engineering study application engineering design development maintenance software web testing name given software testing focuses web applications regression testing means testing application code modified verify still functions correctly test cases develop using reusability constraints must act priority based test cases regression testing execute cases basis priority area coverage adaptive tcp algorithm used provide sequence execution sequence optimized genetic algorithm uses population size crossover mutation probability generation new childs
segmentation classification objects images one important yet one complex problems computer vision work propose new model natural image object classification using contextual information level image segments context modeling largely independent appearance based classification proposed model enables simple upgrade existing systems information global local context context modeling based non parametric use appearance based classification results novel approach compared previous systems model context limited number rules expressed fixed set parameters model implementation resulted system simulations showed stable improvement appearance based object classification
paper presents laboratory scale implementation chopper soft starter topology three phase induction motors designed used power quality power electronics didactical laboratories project proposal students electrical engineering control engineering issue costs considered constraint components chosen based feasibility project availability local stores reduce required programming skills control algorithm developed using arduino platform paper also presents simulation results real results prototype
patients schizophrenia show specific abnormalities visual perception patients bipolar disorder may related perceptual deficits tasks highlight perceptual dysfunction patients schizophrenia show abnormal activity visual brain areas including lateral occipital complex loc early retinotopic cortex unclear whether anatomical structure visual areas atypical schizophrenia bipolar disorder members two patient groups healthy controls localized loc early retinotopic cortex individually participant using functional magnetic resonance imaging mri measured thickness regions interest using structural mri scans regions patients schizophrenia thinnest cortex controls thickest cortex bipolar patients intermediate cortical thickness control region motor cortex show pattern group differences thickness visual region interest significantly correlated performance visual object masking task schizophrenia patients findings suggest anatomical substrate visual processing abnormalities found neural behavioral measures schizophrenia severe mental illnesses
purpose purpose research investigate organizations best facilitate empowered workforce makes autonomous decisions acts expediently literature high performing organizations posits increase likelihood sustained performance retaining competitive advantages introduce novel mechanism encouraging behaviors pursuant outcomes vicarious learning supervisor demonstrates autonomy expediency design methodology approach drew experimental data sample participants underwent managerial simulation used data investigate relationships vicarious learning empowered behaviors individual task performance findings results indicate supervisors behave autonomy expediency increases extent individuals behave similarly associated enhanced individual performance find expedient behavior fully mediates relationship empowered supervisor behavior performance implications findings show supervisors need necessarily engage directly empowering others rather modeling behaviors supervisors craft context employees may act autonomy efficiency provides opportunity empowerment actionable cost effective originality value first study consider empowerment managerial phenomenon vicariously learned integrating theories social learning empowerment extending existing empowerment constructs including psychological structural develop indirect yet potent means encouraging empowered behavior
psychiatric symptoms patients frontotemporal dementia ftd highly prevalent may complicate clinical management patients purpose present article present discuss available data pharmacological treatment psychiatric symptoms patients ftd research main database sources conducted obtain overview pharmacological management psychiatric symptoms patients ftd search strategy included following termsftd psychiatry ftd behavioural disturbances ftd treatment pathophysiology psychiatric symptoms ftd different types dementia although drugs alzheimer disease appear ineffective treatment psychiatric symptoms ftd preliminary evidence supports possible usefulness serotonergic antidepressants patients data scanty draw definitive conclusions antidepressant treatment particularly serotonergic compounds may improve psychiatric symptoms patients ftd large observational studies needed confirm preliminary evidence lot effort collaboration neurologists psychiatrists definitely crucial future research effective treatments ftd
paper presents customizable sensing system based functionalized nanowires nws assembled onto complementary metal oxide semiconductor cmos technology micro nano chip integrates top electronics array aluminum microelectrodes covered gold means customized electroless plating process assembly process driven array chip dielectrophoresis dep generators enabling custom layout different nanosensors microelectrode array electrical properties assembled singularly sensed situ cmos read circuit roc guarantees low noise reliable measurement chip directly connected external microcontroller configuration data processing processed data redirected workstation real time data visualization storage sensing experiments proof concept zno nanowires integrated onto chip validate approach enables different kind sensing experiments device irradiated external source adjustable power measure zno sensitivity light exposure maximum variation zno resistance detected system assembled single zno exposed estimated incident radiant light flux range performed experiments prove efficiency platform conceived exploiting kind material change capacitance resistance due external stimulus
fiber optical gyro fog kind solid state optical gyroscope good environmental adaptability widely used national defense aviation aerospace civilian areas applications fog experience environmental conditions vacuum radiation vibration scale factor performance concerned important accuracy indicator however scale factor performance fog environmental conditions difficult test using conventional methods turntable work environmental conditions according phenomenon physical effects fog produced sawtooth voltage signal static conditions consistent physical effects fog produced turntable uniform rotation new method scale factor performance test fog without turntable proposed paper method test system scale factor performance constituted external operational amplifier circuit fog modulation signal waveguied disconnected external operational amplifier circuit used superimpose externally generated sawtooth voltage signal modulation signal fog exert superimposed signal waveguide fog test system produce different equivalent angular velocities changing cycle sawtooth signal scale factor performance test paper system model fog superimposed externally generated sawtooth analyzed conclusion effect equivalent input angular velocity produced sawtooth voltage signal consistent effect input angular velocity produced turntable obtained relationship equivalent angular velocity parameters sawtooth cycle presented correction method equivalent angular velocity also presented analyzing influence parameter error equivalent angular velocity comparative experiment method proposed paper method turntable calibration conducted scale factor performance test results fog using two methods consistent using method proposed paper test scale factor performance fog input angular velocity equivalent effect produced sawtooth voltage signal need use turntable produce mechanical rotation method used test performance fog ambient conditions turntable work
elderly people especially institutionalized long term care facilities risk various oral diseases aim study determine incidence hyposalivation colonization oral fungal infection oral cavity yeasts well dental status institutionalized non institutionalized elderly study included institutionalized non institutionalized elderly people salivary flow rate oral colonization yeasts oral infection dental status assessed compared groups institutionalized elderly significantly lower salivary flow rate oral colonization yeasts frequently found institutionalized elderly compared non institutionalized elderly negative correlation found decreased salivary flow rate oral yeast colonization oral fungal infection institutionalized non institutionalized groups significant difference dmft index observed two groups negative correlation decreased salivary flow rate dental status found institutionalized non institutionalized groups results revealed significantly higher level hyposalivation oral yeast colonization poorer dental status institutionalized group compared non institutionalized group elderly people
summary twenty five percent patients non hip non vertebral fragility fracture undiagnosed vertebral fracture detected vertebral fracture assessment bone densitometric assessment prevalence undiagnosed vertebral fracture higher older people likely multiple vertebral fractures purpose vertebral fragility fractures vff history trauma vertebral fracture assessment vfa dual energy ray absorptiometry dxa used detect vffs study aims identify prevalence undiagnosed vff patients presenting non hip non vertebral fragility fracture methods patients identified fracture liaison service fls large university hospital presenting non hip non vertebral fragility fracture evaluated january september local protocol identified would proceed vfa data collected patient characteristics fracture details bone mineral density bmd measurements vfa results results five hundred sixty seven patients mean age years mostly women vfa performed part dxa assessment one hundred forty three patients identified vertebral fracture one fracture vertebral fractures bmd measurements diagnostic osteoporosis mean age higher vertebral fractures compared without years years aged years likely multiple fractures younger years conclusion quarter patients presenting non hip non vertebral fragility fracture undiagnosed vertebral fracture older people likely vertebral fractures likely multiple fractures vfa bone densitometric assessment aid stratifying future fracture risk
background azathioprine commonly prescribed therapy connective tissue disease associated interstitial lung disease ctd ild combination therapy included azathioprine recently shown increase risk death hospitalization patients idiopathic pulmonary fibrosis whether azathioprine increases risk adverse outcomes patients fibrotic ctd ild including ctd associated usual interstitial pneumonia uip remains unknown methods retrospective cohort analysis performed determine combined incidence rate death transplant respiratory hospitalization associated azathioprine exposure fibrotic ctd ild cohort treated mycophenolate mofetil served comparator group incidence rates compared incidence rate ratio irr generated negative binomial regression longitudinal pulmonary function response assessed using mixed effects linear regression models results fifty four patients treated azathioprine forty three mycophenolate medication discontinuation due non respiratory side effects occurred azathioprine mycophenolate cohorts respectively combined incidence rate adverse outcomes azathioprine mycophenolate respectively irr similar incidence rates observed among ctd uip irr groups demonstrated pulmonary function stability time azathioprine group demonstrating marginal improvement conclusions significant minority patients could tolerate azathioprine due non respiratory side effects tolerate azathioprine similar incidence adverse outcomes observed treated mycophenolate therapies associated stability pulmonary function elsevier ltd rights reserved
background heterogeneous progression idiopathic pulmonary fibrosis ipf makes prognostication difficult contributes high mortality waitlist lung transplantation ltx multidimensional scores composite physiologic index cpi gender age physiology gap risk stratification score rise demonstrated enhanced predictive power towards outcome ipf lung allocation score las multi dimensional tool commonly used stratify patients assessed ltx sought investigate whether ipf specific multi dimensional scores predict mortality patients ipf assessed ltx methods study included patients ipf underwent ltx assessment multi dimensional scores calculated primary outcome month mortality assessment ltx considered competing event analyses results end observation period transplants deaths patients alive without ltx multi dimensional scores predicted mortality accuracy similar las superior individual variables area curve auc las sensitivity specificity cpi sensitivity specificity gap sensitivity specificity rise sensitivity specificity separate analysis conducted patients actively listed ltx deaths yielded similar results conclusions patients ipf assessed ltx well actually listed multi dimensional scores predict mortality better individual variables accuracy similar las validated multi dimensional scores may serve inexpensive tools guide decisions timing referral listing ltx elsevier ltd rights reserved
introduction research reported smiles facilitate social relationships however effect smile driving behavior received less interest method study attempts evaluate pedestrian smile influences oncoming driver behavior first part study male female research assistants waiting several pedestrian crossings asked smile oncoming drivers results found smile increases number drivers stop effect observed pedestrian tries cross outside pedestrian crossing finally study shows motorists drive slower see pedestrian smile suggesting smile induce positive mood practical applications leads motorists stopping readily driving carefully results also suggest pedestrians may increase safety using appropriate nonverbal signals toward drivers national safety council elsevier ltd rights reserved
smart power integrated circuits receive increasing attraction recently especially automotive industry substrate noise coupling one major causes failure kind integrated circuits requires circuit redesign increases overall cost exhaustive failure analysis needed identify failures due substrate coupling paper present post layout extraction simulation methodology substrate parasitic modeling based methodology developed dedicated computer aided design tool used substrate extraction layout patterns extraction employs meshing algorithm substrate parasitic generation validate substrate model process benchmarking uses industrial design structures high voltage cmos technology two test cases transient simulation considered work first one common used current mirror circuit tool predicts interference substrate currents basic circuit second test case industrial design test chip parasitic coupling investigated standard automotive test eventually using proposed cad tool becomes possible simulate behaviors substrate noise early phase fabrication
purpose investigate model language development nonverbal preschool age children learning communicate augmentative alternative communication method ninety three preschool children intellectual disabilities assessed time children assessed year later time outcome variable number different words children produced speech sign speech generating devices children intrinsic predictor language modeled latent variable consisting cognitive development comprehension play nonverbal communication complexity adult input school home amount augmentative alternative communication instruction proposed mediators vocabulary acquisition results confirmatory factor analysis revealed measures converged coherent construct structural equation model indicated intrinsic child predictor construct predicted different words children produced amount input received home school significant mediator conclusions hypothesized model accurately reflects latent construct intrinsic symbolic factor isf children evidenced higher initial levels isf adult input home produced words year later findings support need assess multiple child variables suggest interventions directed indicators isf input
micrornas emerged important regulators osteoclast differentiation recent years mir reported play important role bone development however role underlying mechanism osteoclast differentiation remains poorly understood study aimed investigate precise role molecular mechanism mir osteoclast differentiation found obvious increase mir expression osteoclast differentiation osteoclast precursors induced receptor activator nuclear factor kappa kappa ligand macrophage colony stimulating factor vitro experiments showed overexpression mir significantly promoted osteoclast differentiation suppression mir showed opposite effect interestingly bioinformatics analysis dual luciferase reporter assays showed mir targets untranslated region leucine rich repeat containing protein coupled receptor lgr expression lgr regulated mir osteoclasts moreover mir regulated kappa glycogen synthase kinase beta signaling osteoclast differentiation overexpression lgr partially reversed promoting effect mir overexpression osteoclast differentiation taken together study suggests mir contributes osteoclast differentiation targeting lgr providing novel insights understanding molecular mechanism underlying osteoclast differentiation elsevier rights reserved
consider scalar balance law strict convex flux paper study stability shock scalar balance law shift function based relative entropy result generalizes leger works provides simple proof leger proof
solar energy considered alternative sustainable energy source urban environment potential using solar energy urban areas highly dependent urban morphology affects level solar irradiance received individual buildings many studies focus solar energy potential building form urban areas relatively studies examine urban morphology affects solar energy potential urban neighbourhoods leads inefficient design neighbourhoods terms solar energy potential present study investigates potential exploiting solar energy dar salaam tanzania using numerical modelling solar irradiance building roofs facades shown substantial solar irradiance received building roofs four study neighbourhoods urban morphology considerable effects annual solar irradiance solar irradiance different orientations tilted roofs facades subject seasonality solar azimuth angle suggested abundant solar energy sources would provide solutions accommodate increasing energy demand improve living quality urban areas due rapid urbanization city elsevier ltd rights reserved
low testosterone associated late onset hypogonadism age related disease type diabetes cardiovascular disease study investigated effects kaempferia parviflora extract two components dimethoxyflavone hydroxy tetramethoxyflavone testosterone production mouse testis derived tumour cells parviflora fractions containing dimethoxyflavone elicited testosterone production cells nobiletin polymethoxyflavonoid found citrus species paruiflora used comparative control furthermore found compounds enhanced testosterone production via cyclic amp camp camp response element binding protein signalling particular compounds inhibited activation phosphodiesterase thereby increased production camp findings support possibility paruiflora extract dimethoxyflavone nobiletin may mitigate age related disease hypogonadism enhancing testosterone production elsevier ltd rights reserved
enhanced pond systems eps effective economic upgrade option conventional wastewater treatment ponds providing improved natural disinfection nutrient removal moreover wastewater nutrients recovered harvested algal biomass beneficial use fertiliser feed biofuel feedstock low cost construction operation crucial factors adoption eps paper presents novel economic design construction operation methods earthen hectare scale eps treating domestic wastewater cambridge wastewater treatment plant new zealand system consisted existing anaerobic pond settle anaerobically digest wastewater solids retrofitted cover capture biogas two hectare hraps aerobically treat remove nutrients anaerobic pond effluent production algal biomass algal harvest ponds settle concentrate algal biomass pumped covered digester pond recover energy biogas nutrients concentrated digestate effluent polishing provided maturation ponds rock filters achieve higher quality effluent ponds earthen construction made within existing disused conventional wastewater treatment ponds cost effective earthen pond construction combined use protective geotextile geomembrane liners geomembrane covers painted steel paddlewheels precast concrete carbonation sumps enable economic implementation eps energy efficient effective wastewater treatment well nutrient recovery energy production local community
although introduction commercial rgb sensors enabled significant progress visual navigation methods mobile robots structured light based sensors like microsoft kinect asus xtion pro live important limitations respect range field view depth measurements accuracy recent introduction second generation kinect based time flight measurement principle brought robotics computer vision researchers sensor overcomes limitations however new kinect like older one intended computer games human motion capture rather navigation unclear much navigation methods visual odometry slam benefit improved parameters many publicly available rgb data sets provide ground truth information necessary evaluating navigation methods best knowledge none contains sequences registered new version kinect therefore paper describes new rgb data set first attempt systematically evaluate indoor navigation algorithms data two different sensors environment along trajectories data set contains synchronized rgb frames sensors appropriate ground truth external motion capture system based distributed cameras describe details data registration procedure evaluate rgb visual odometry algorithm obtained sequences investigating specific properties limitations sensors influence performance navigation method
background youth autism spectrum disorder asd risk one emotional disorders including depressive anxiety conditions dsm diagnostic guidelines indicate occurring must specified present may evaluated initial diagnostic assessment routine monitoring screening needed identify emerging later childhood adolescence period high risk method confirmatory factor analysis convergent divergent validity analyses criterion related validity diagnostic accuracy analyses cbcl affective problems anxiety problems dsm oriented scales completed well characterized youth ages years asd without intellectual impairment youth predominately white middle class backgrounds results scale measured single construct reliably depressive anxiety disorders neither scale measured symptoms asd youth depressive disorder morbidities conclusions findings demonstrate dsm oriented affective anxiety problem scales used screen depression anxiety youth asd replication needed various subgroups representing gender age developmental level autism mental health severity differences groups across broader set demographics elsevier ltd rights reserved
background many dental problems tooth decay starts childhood regard attitudes beliefs mothers oral dental health important aim study determine factors affecting oral dental health children mothers referred qom health centers using health belief model materials methods cross sectional descriptive analytic study performed among mothers children health dossier qom health centers iran using multi stage sampling sample size formula mothers selected randomly health assessment centers required data target group collected questionnaire health belief model field oral health data analyzed using spss results results showed positive significant relationship mothers behavior towards oral dental health perceived benefits self efficacy respectively also negative significant statistically relationship mother behavior towards oral dental health perceived barriers addition positive significant relationship mother behavior toward oral dental health children behavior towards issue conclusion findings indicator importance usage health belief model assessing mothers perceptions beliefs oral dental health modeling behavior reinforcing healthy behaviors children
aim objectives research focused analysis orofacial motor skills children autism spectrum disorder asd used special speech language therapy software programme evaluate quality orofacial movements children asd research strategy based relations motor dyspraxia problems disturbed nonverbal communication patterns generally could influenced even children asd main focus research emerged wider focus assessment pragmatic language level represents one deficit area persons asd believe ability production facial expression gestures represents one important part pragmatic nonverbal communication activities methodology assessed orofacial motor abilities children asd initial final phase examination used selected part software programme fono multimedia programme therapy clients impaired communication ability evaluation progress stagnation regress child used observational numerical scale evaluation subsequently compared difference phases longitudinal observation conclusions results proved possibility achieving least partial positive results based application systematic speech language therapeutic approach based using speech
previous studies suggested tendency externalize internal thought related auditory hallucinations even proneness auditory hallucinations ahp general population however although auditory hallucinations related emotional phenomena studies investigated effect emotional valence aforementioned relationship addition know component psychotic phenomena relate externalizing bias current study replicated previous research suggested individual differences auditory hallucination like experiences strongly correlated external misattribution internal thoughts conceptualized terms false memory using deese roediger mcdermott drm paradigm found significant relationship experimental performance total scores launay slade hallucination scale lshs among lshs factors vivid mental image said predictor auditory hallucinations significantly related experimental performance investigated potential effect emotional valence using drm paradigm results indicate participants low scores lshs low ahp group current study showed increased discriminability index positive words decreased negative words however effects emotional valence found participants high lshs scores high ahp group study indicated external misattribution internal thoughts predicts ahp high ahp group showed smaller emotional valence effect drm paradigm compared low ahp group discuss outcome perspective dual process activation monitoring framework drm paradigm regard emotion driven automatic thought false memory
hydrophobic drug lamotrigine ltg shows low bioavailability oral administration work performed improve aqueous solubility ltg using micelles amphiphilic block copolymers polyethylene oxide polypropylene oxide polyethylene oxide triblock copolymers peo ppo peo known pluronic subject current interest due versatile structural possibilities varying peo ppo ratios incorporation ltg aqueous micellar solutions pluronic investigated using visible spectroscopy shapes size micelles without ltg ascertained using dynamic light scattering small angle neutron scattering experiments results show increase pluronic micellar size hard sphere radius incorporation ltg effect hydrophilic polymers peg ltg incorporated pluronic micelles also studied found inefficient enhancement solubility ltg solid forms ltg incorporated pluronic micelles without hydrophilic polymers coded lpms successfully prepared thin film hydration method fourier transform infrared spectroscopy ray diffraction spectroscopy thermogravimetric analysis used ensure compatibility ltg pluronic micelles prepared lpms lpms showed good incorporation efficiency loading capacity sustained release profile ltg results showed specific improvement addition hydrophilic polymers studied concentration range
seek infinite sequence exact solutions dimensional mew equation paper utilize expansion method give nonlinear superposition formula backlund transformation solutions riccati equation obtain equation infinite sequence exact solutions help symbolic computation system mathematica new infinite sequence exact solutions obtained
alpha synuclein alpha syn major gene linked sporadic parkinson disease whereas alpha syn mutation causes familial form characterized early onset generally severe phenotype including nonmotor manifestations generated novo induced pluripotent stem cells ipscs patients harboring mutation developed robust model captures pathogenic processes basal conditions ipsc derived mutant neurons displayed novel disease relevant phenotypes including protein aggregation compromised neuritic outgrowth contorted fragmented axons swollen varicosities containing alpha syn tau identified neuropathological features closely resembled brains patients small molecules targeting alpha syn reverted degenerative phenotype basal induced stress conditions indicating treatment strategy synucleinopathies furthermore mutant neurons showed disrupted synaptic connectivity widespread transcriptional alterations genes involved synaptic signaling number previously linked mental disorders raising intriguing implications potentially converging disease mechanisms
paper presents initial investigation controller tuning effect membrane fouling submerged membrane bioreactor smbr work employed proportional integral derivative pid controller control smbr filtration process pid controller tuned using three different methods ziegler nichols cohen coon integral time weight absolute error itae tuning pid controller used control smbr filtration permeate flux transmembrane pressure tmp observed filtration process determine fouling effect controller tuning simulation work done using artificial neural network ann model developed previous work different set points tested see robustness controller tuning overall result shows itae tuning method performs better compare tuning methods term overshoot settling time integral absolute error iae second respectively tuning method provides precise control performance time prevent decrement flux filtration cycle
false memories created using deese roediger mcdermott drm paradigm paradigm used induce false memories words pictures extended induce false memories brand names present first experimental evidence false memories created competitor brands using television adverts first experiment participants saw sets adverts related products types chocolate second watched television programme interspersed advertisements false memories related non presented brands occurred experiments second experiment participants tested using emember uess recognition task immediately week later correct memory presented brands decreased time whilst false memories increased findings pose challenge advertisers current theories false memory particularly increase false memory detailed emember responses society applied research memory cognition published elsevier inc rights reserved
research presents encryption technique based programmable cellular automata pca theory realizing hardware cryptosystem applied high speed data communication networks pca blocks proposed article makes encryption system much resistant different types attacks cellular automata parallel information processing property give high speed paper shown series simple elements called cells interact using certain evolution rules topologies form larger body acts like encryption system proposed architecture implemented efficiently hardware reconfigurable systems experimental hardware platform based xilinx fpga xcse used prototyping proposed algorithm encryption decryption modules results demonstrate proposed encryption algorithm properties large key space high sensitivity key distribution encrypted text ascii intervals resisting differential attacks cryptosystem practical secure
whether people seek help depends estimations likelihood value getting although past research carefully examined accurately help seekers predict whether help requests granted failed examine accurately help seekers predict value help receive paper focus accurately help seekers predict key determinant help value namely helper effort four studies find helpers put effort helping help seekers expect studies people underestimate effort others expend general rather effort others expend helping study underestimation help effort stems help seekers failure appreciate discomfort particular guilt helpers would experience enough help studies elsevier inc rights reserved
magnetically levitated planar motor new generation motion device modern precision industry advanced motion controller design still main concern paper learning adaptive robust control larc motion controller proposed developed magnetically levitated planar motor achieve good tracking performance planar motor consists halbach permanent magnetic array stator levitated platen containing four groups three phase windings mover based lorentz force law mover placed magnetic field subject vertical force levitation horizonal force planar motion dynamics decoupling current allocation larc control scheme including iterative learning term adaptive model compensation term parallel structure proposed magnetically levitated planar motor meet challenge high performance tracking even parametric uncertainty comparative experiments carried planar motor track point point planar circular motions respectively results consistently validate proposed larc control strategy achieves good tracking performance even payload proposed scheme actually provide practically effective technique guidance motion control magnetically levitated planar motors industrial applications
atopic dermatitis defined chronic highly pruritic inflammatory condition skin estimated disease may lead significant morbidity also adversely affects quality life atopic dermatitis responds well home treatment proper skin care reduces need medicines topical creams oral antihistamines used suppress symptoms clinical trial conducted patients control test taking written consent dermovix significantly improved skin symptoms associated dermovix ointment safe well tolerated specified age group patients overall results individual group analyzed using paired sample test level significance symptoms calculated drugs showed similar efficacy calculated value except case dry skin test drug shown significant value compare effects patients complaints test group shown better results side effects
background data obesity prevalence children intellectual disability scarce objective estimated rates obesity among children aged years without nationally representative dataset included measures child weight status well family meal frequency physical activity sedentary behavior methods chi square tests compared prevalence obesity demographic behavioral characteristics children without reported national survey children health tests interaction logistic regression models determined whether associations obesity behavioral characteristics different children without results obesity prevalence children children without adjusting age sex race ethnicity poverty level odds ratio significantly times greater among children among without among children ate least one meal family members every day compared without participated frequent physical activity compared prevalence obesity higher among children ate family meals every day compared fewer days per week effect significantly pronounced among conclusions prevalence obesity among youth almost double general population prospective studies needed population examine impact consistent family mealtimes infrequent physical activity elsevier inc rights reserved
single root virtualization iov specification allows single pci express pcie device physical function used multiple pcie devices virtual functions virtualization system directly assigned virtual machine passthrough mode significantly improve network performance however passthrough mode compatible live migration essential capability enables many advanced virtualization features high availability resource provisioning solve problem design srvm provides hypervisor support ensure device correctly used migrated applications srvm implemented hypervisor without modification guest operating systems guest drivers experimental results show srvm effectively migrate memory state data loss corruption applications live migration srvmdoes increasevmdowntime costs limited resources extra cpu core significant runtime overhead network performance fact since continue used pre copy phase offers network throughput times network latency lower compared solutions switch para virtualization mode live migration
background gastrointestinal discomfort bloating rumbling common symptom otherwise healthy adults approximately population particularly women suffer gastrointestinal discomfort affects quality life recent studies discovered link body mind called gut brain axis psychosocial factors daily stress may cause altered gut physiology leading ileum contractions consequently gastrointestinal symptoms vitro vivo studies clearly showed perilla frutescens extract combines prokinetic antispasmodic anti inflammatory effects aim intervention investigate effects proprietary perilla extract discomfort healthy subjects gastrointestinal discomfort reduced bowel movements comparison placebo product methods pilot study performed according double blind randomized placebo controlled parallel design fifty healthy subjects gastrointestinal discomfort reduced bowel movements years documented symptoms stool frequency consistency daily week run phase week intervention phase perilla frutescens extract placebo symptoms assessed point scale daily average scores days intervals calculated results symptoms significantly improved time perilla frutescens extract intervention phase bloating passage gas rumbling feeling fullness abdominal discomfort whereas placebo group abdominal discomfort significantly improved subgroup women results strengthened subscore bloating abdominal discomfort significantly improved placebo conclusion demonstrated effects perilla frutescens extract improve complaints offer promising results taking consideration challenging set nutritional human study healthy subjects area digestive health known high placebo effects
pegylated interferon plus ribavirin recommended standard care treatment chronic hepatitis virus hcv infection india open label phase study conducted across sites india march november evaluated efficacy safety sofosbuvir plus ribavirin therapy among treatment naive patients chronic genotype hcv infection total patients genotype hcv infection randomized receive sofosbuvir weight based ribavirin daily weeks among genotype infection primary efficacy endpoint sustained virologic response weeks post treatment svr reported confidence intervals patients following weeks treatment respectively patients genotype infection svr rates weeks therapy respectively adverse events mild moderate severity occurred patients receiving weeks treatment respectively common treatment emergent adverse events asthenia headache cough one patient week group discontinued treatment sofosbuvir study overall sofosbuvir plus ribavirin therapy achieved svr rates well tolerated among treatment naive patients chronic genotype hcv infection india
dormant tailings storage facilities tsfs negative effects surrounding environments communities study aimed determining financial practical feasibility generating energy ergo tsf site near brakpan johannesburg beneficial post closure land use option beneficial post closure options investigated rainwater harvesting electricity generation wind power photo voltaic solar power pump storage system constructed tsf wind power generation rainwater harvesting site found unviable found peak capacity solar photo voltaic plant top ergo tsf provide best solution practical financial point view yielding potential internal rate return irr years pump storage system yields maximum irr substantially smaller generation capacity approximately
contemporary genetic research provided evidences angioedema represents diverse family disorders related kinin metabolism much greater genetic complexity initially considered convincing data also recently published indicating clinical heterogeneity hereditary angioedema due inhibitor deficiency classified inh hae could attributed least part either type serping mutations mutations genes encoding enzymes involved metabolism function bradykinin alterations detected least one gene nowadays considered responsible cases hereditary angioedema normal inh type iii hereditary angioedema hae nlc inh hae interesting data derived genetic approaches non hereditary angioedemas indicate immune pathways might implicated pathogenesis hae years recognition hereditary nature hae osler heterogeneity clinical expressions genetics disorder genotype phenotype relationships still presents challenge discussed review large scale depth genetic studies expected answer emerging questions also elucidate many unmet aspects angioedema pathogenesis uncovering genetic biomarkers affecting severity disease effectiveness various treatment modalities might lead prevention attacks optimization inh hae management expected provide valuable benefit sufferers angioedema
importance faces person recognition subject many studies relatively studies examining recognition whole person motion even though closely resembles daily experience studies examining whole body motion use point light displays many advantages impoverished unnatural compared real life determine factors used recognizing whole person motion conducted two experiments using naturalistic videos experiment used matching task first stimulus pair could either video multiple still images video full body second stimulus person recognition performed could image either full body face alone found body contributed person recognition beyond face exposure motion since person recognition performed still images contribution motion person recognition mediated form motion processes assess whether dynamic identity signatures may also contribute person recognition experiment presented people motion examined person recognition videos compared still images results show dynamic identity signatures contribute person recognition beyond form motion processes conclude face body form motion processes appear play role unfamiliar person recognition suggesting importance considering whole body motion examining person perception elsevier ltd rights reserved
although women type diabetes experience normal transition menopause little information impact hormone replacement therapy glycemic profiles year old postmenopausal woman fulminant type diabetes admitted hospital due diabetic ketoacidosis treated fluid replacement continuous insulin infusion thereafter glycemic profile well maintained daily multiple insulin injections however glycemic profiles immediately deteriorated following administration progesterone hormone replacement therapy transient deterioration implies external progesterone lead deterioration glycemic profiles postmenopausal women type diabetes
notch pathways important regulators beginning genetic mechanisms controlling embryonic development cell differentiation required normal pancreatic development embryonic period disruption notch pathway induces apoptosis pancreatic cells corrupted pancreatic development lead diabetes genetic mutations affecting notch pathway extensively studied certain types cancer including solid tumours metabolic functions well known objective study explore relationship notch gene variants risk developing type diabetes mellitus patients healthy control subjects polymerase chain reaction restriction fragment length polymorphism pcr rflp carried identify genotypes patients diabetes control individuals dna extracted peripheral blood samples amplified variant digested mwoi variant digested acii products evaluated agarose gel electrophoresis obtained results suggested variant associated development type diabetes due significant ratio presence allele similarly presence genotype absence allele determined associated notable risk developing type diabetes individuals variant conclusion found significant association variants notch gene risk developing type diabetes mellitus
obtain travelling wave solutions nonlinear richard equation expressing water content moisture content unsaturated porous media present analysis typical forms hydraulic conductivity diffusivity functions proposed witelski considered particular travelling wave solutions richard equation nonlinear diffusivity hydraulic conductivity presented governing nonlinear partial differential equation solved modified expansion method help symbolic computation system mathcmatica soliton like solutions obtained physical interpretation considered specific initial value problem obtained solutions reveal method effective powerful tool solving various nonlinear partial differential equations arising mathematical physics authors published elsevier ltd
objective provided benchmark estimates probability pregnancy given single act intercourse calculations assumed intercourse ovulation independent subsequent research shown assumption valid provide update previous benchmark estimates study design reanalyze earlier data two north carolina studies collected daily urine samples recorded daily intercourse multiple menstrual cycles one study comprised sexually active women either intrauterine device tubal ligation second women planned become pregnant discontinued use birth control enrollment participants known fertility problems new statistical analyses based monte carlo simulations bayesian methods results probability single act intercourse occurs within woman fertile window compared previous calculations probability pregnancy intercourse given menstrual cycle day correspondingly higher previously estimated largest increases occurring menstrual days increases however fairly small example peak chance conception menstrual day increased conclusions previous benchmark rates pregnancy one act intercourse moderately underestimated due mistaken assumption independence intercourse ovulation implications statement chance pregnancy single act unprotected intercourse greater previously estimated previous benchmarks may underestimate efficacy post coital contraception published elsevier inc
circulating micrornas mirnas shown promising biomarkers various diseases investigated predictive potential circulating endothelium enriched mir type diabetes patients without chronic complications patients coronary artery diseases cad expression levels circulating mir determined quantitative real time pcr decrease peripheral blood patients cad compared healthy controls mir strongly associated cad negatively correlated ldl cad patients differentiated patients patients cad healthy subjects circulating mir may serve biomarker predicting patients diabetic cad
objective interest increased regarding issue contraception transplant recipients purpose study assess birth control selection role contraceptive counseling sessions female kidney transplant liver transplant recipients study design cross sectional single center survey study female organ recipients aged years met study criteria patients asked questions regarding pre posttransplantation use contraceptive methods birth control awareness contraception counseling factors determining selection effective contraception hormonal contraception intrauterine devices female sterilization results thirty three percent patients undergone transplantation within year prior study inclusion unaware necessity use contraception groups studied differ significantly terms rates pre posttransplantation consultations effective contraception effective posttransplantation contraception used one three patients indicated posttransplantation consultations following factors affected posttransplantation use effective contraception presence posttransplantation counseling effective contraception odds ratio confidence interval infrequent sexual activity prior transplantation conclusion selection effective contraception recipients remain suboptimal despite low numbers women received contraceptive counseling study consultation nonetheless associated choosing effective method contraception elsevier inc rights reserved
purpose review purpose review summarize evidence recently published original studies investigating glutathione transferase gst gene polymorphisms modify impact air pollution asthma allergic diseases lung function recent findings current studies epidemiological controlled human experiments found evidence suggest gsts modify impact air pollution exposure respiratory diseases allergies nine articles included review except one identified least one significant interaction least one glutathione transferase gstp glutathione transferase gstm glutathione transferase theta gstt genes air pollution exposure findings studies however markedly different difference partially explained regional variation exposure levels oxidative potential different pollutants interactions involving number unaccounted environment exposures multiple genes summary although evidence interaction gst genes air pollution exposure risk respiratory disease allergies results concordant investigations needed explore reasons behind discordancy
questions month behaviour change intervention targeting physical activity increase habitual physical activity adults ankylosing spondylitis intervention improve health related physical fitness related features attitude exercise gains maintained month follow design parallel group randomised controlled trial concealed allocation assessor blinding intention treat analysis participants forty adults diagnosis stable medication without limiting comorbidities intervention month period experimental group engaged individually tailored semi structured consultations aiming motivate support individuals participating control group continued usual care outcome measures primary outcome measured accelerometry week secondary outcomes included clinical questionnaires measures health related physical fitness measures taken baseline post intervention month follow period results baseline characteristics similar across groups except age body composition statistically significant moderate large time group effects health enhancing mixed design anova overall effect spinal mobility quality life chi favouring intervention group post intervention improvements sustained months later significant effects seen physical fitness outcomes clinical questionnaires adverse effects reported study conclusion health enhancing spinal mobility quality life significantly improved intervention improvements maintained month follow australian physiotherapy association published elsevier
traditional digital computing demands perfectly reliable memory processing programs build structures use foreverbut deterministic execution becoming ever costly large scale systems contrast living systems viewed computations naturally tolerate fallible hardware repairing rebuilding structures even useand suggest ways compute using massive amounts unreliable merely best effort hardware however currently know little programming without deterministic execution architectures traditional models computationand deterministic alife models game lifeneed apply expanded article presents ulam language designed balance concurrency programmability upon best effort hardware using lifelike strategies achieve robust scalable computations article reviews challenges traditional architecture introduces active media computational model ulam designed presents language touching nomenclature surface appearance well broader aspects robust software engineering several ulam examples presented article concludes brief consideration couplings computational model physical implementation
overhead high voltage transmission lines hvtls extend diverse geographic regions uneven weather conditions sag wind induced conductor motion poses serious issues uninterrupted power distribution hvtls sag reduces ground clearance line whereas conductor motion may result phase phase short circuit damage support structure real time estimate factors deemed important develop requisite prevention measures paper present novel method cater sag motion estimation real world scenarios method detect change sag conductor motion whether symmetrical unsymmetrical one conductors require uniaxial magnetic field sensors mounted support tower equal conductors synchronized current transformer data substation sensors provide noncontact measurements time stamped transmitted substation data simultaneously processed along electric current readings processing developed unified algorithm first distinguishes variation sag motion conductor estimates corresponding sag motion conductors method verified first numerical simulations scaled setup laboratory different test cases identified algorithm error remains unsymmetrical sag estimation addition trajectory conductor motion retrieved root mean square error actual retrieved conductor amplitude observation window
vaccines rank among greatest advances history public health yet despite need licensed vaccines protect humans fungal diseases including aspergillosis focused review major scientific logistical challenges developing vaccines protect risk individuals aspergillosis discussed approaches shown promise animal models include vaccines protect multiple fungal genera specifically directed aspergillus advances proteomics glycomics facilitated identification candidate antigens use subunit vaccines novel adjuvants delivery systems becoming available skew vaccine responses toward associated protection immunotherapy consisting adoptive transfer aspergillus specific cells allogeneic hematopoietic transplant recipients advanced human testing technically difficult unproven benefit progress impressive much work still needs done vaccines aspergillosis become reality
link community environment individual health outcomes widely documented western literature little known whether community context influences children health individual characteristics developing countries study examines community socioeconomic status ses influences children self rated health nutritional status urban rural china explores whether effects community ses vary child gender family background using data china family penal studies study focuses children aged years old living urban neighborhoods rural villages china multilevel regression models estimated examine effect community ses probability reporting poor fair health nutritional status measured height age controlling individual family characteristics results suggest community ses positive curvilinear effect children health nutritional status urban china positively influences children nutrition rural china community ses stronger effect boys girls children poorer families families lower levels parental involvement elsevier ltd rights reserved
biosimilar remicade agent approved countries use inflammatory bowel disease ibd controlled clinical trials demonstrated efficacy safety rheumatic diseases ibd assess effectiveness safety ibd patients real clinical practice prospective observational study patients moderate severe crohn disease ulcerative colitis treated study performed one single center patients included naive switched anti tnf treatment reference infliximab remicade efficacy safety assessed naive switched patients remission time switch months therapy switched patients remission time switch continued remission naive patients reached remission months switched cases patients remission time switch continued remission months naive patients remission rates months adverse events occurred patients months study efficacious well tolerated patients
context objectification violence little attention paid perception neuroscience human brain perceives bodies objectifies various studies point external cues appearance attire could play key role encouraging objectification dehumanization denial agency reviewing new experimental findings across several areas research seems common threads run issues clothing sexual objectification body perception dehumanization assault collating findings several different lines research article reviews additional evidence cognitive neural dynamics person perception body face perception processes predict downstream social behavior specifically new findings demonstrate cognitive processing sexualized female bodies object like crucial aspect dehumanized percept devoid agency personhood sexual violence consequence dehumanized perception female bodies aggressors acquire exposure interpretation objectified body images integrating findings identifying triggers sexual violence may help develop remedial measures inform law enforcement processes policy makers alike
study authors propose norm penalised shrinkage linear least mean squares lms algorithm norm penalised shrinkage widely linear least mean squares lms algorithm sparse system identification proposed algorithms exploit priori posteriori errors calculate varying step size thus adapt time varying channel meanwhile cost function introduce penalty term favours sparsity enable applicability sparse condition moreover lms algorithm also makes full use non circular properties signals interest improve tracking capability estimation performance quantitative analysis convergence behaviour lms algorithm verifies capabilities proposed algorithms simulation results show compared existing least mean squares type algorithms proposed algorithms perform better sparse channels faster convergence rate lower steady state error channel changes suddenly filter proposed algorithms adapt variation channel quickly
background recipients high dose standard dose influenza vaccines fewer influenza illnesses evaluated comparative effectiveness high dose vaccine preventing postinfluenza deaths influenza viruses vaccines similar methods identified medicare beneficiaries aged years received high dose standard dose vaccines community located pharmacies offering vaccines primary outcome death days following inpatient emergency department encounter listing influenza international classification diseases ninth revision clinical modification code effectiveness estimated using multivariate poisson regression models effectiveness allowed vary season results studied recipients high dose recipients standard dose vaccines high dose standard dose recipients vaccinees well balanced medical conditions indicators frail health rates postinfluenza death person weeks high dose standard dose recipients respectively comparative effectiveness confidence interval evidence variation season high dose effective reducing mortality conclusions high dose vaccine significantly effective preventing postinfluenza deaths circulation common
network intrusion detection systems nidss developed twenty years widely deployed computer networks detect variety network attacks one major limitations systems would generate large number alarms especially false alarms positives detection address issue many machine learning approaches applied reduce nids false positives however notice multi view based approach often ignored literature uses one function model particular view jointly optimizes functions optimize improve learning performance addition existing studies implemented algorithms practical alam systems paper thus develop mvpsys practical multi view based false alarm reduction system reduce false alarms efficiently view represents set features specifically implement semi supervised learning algorithm construct two view items automatically exploit labeled unlabeled data system automatically extract organize features incoming alarm two feature sets destination feature set source feature set former contains features related target environment latter contains features source environment evaluation deploy system two real network environments besides using two datasets experimental results indicate system achieve stable filtration accuracy offering significant improvement compared state art algorithms elsevier ltd rights reserved
paper proposes high performance graphics processing unit gpu based parity computing scheduler call gpu redundant array inexpensive disks raid reduce encoding decoding time storage applications proposed gpu raid differs existing raid performs additional pairwise parallel xor operations data code words data stripe applying divide conquer approach using extra reserved space also increases parallelism processing multiple strips parallel using multiple gpu threads proposed gpu raid pipelines data blocks solid state disks parity blocks hard disk drives target server proposed algorithm decreases span complexity parity computation schedule log number disks number code words block applied various types erasure codes experimental results show proposed storage application improves average encoding performance average decoding performance compared traditional storage applications gpustore gibraltar raid respectively copyright john wiley sons ltd
biodiversity declines anthropogenic land use change increasingly important understand changing biodiversity affects infectious disease risk dilution effect hypothesis points decreases biodiversity critical increase infection risk received considerable attention due allure win win scenario conservation human well yet empirical data suggest dilution effect generalizable phenomenon explore response pathogen transmission dynamics changes biodiversity driven habitat loss using allometrically scaled multi host model model show declining habitat thus declining biodiversity lead either increasing decreasing infectious disease risk measured endemic prevalence whether larger habitats thus greater biodiversity lead decrease dilution effect increase amplification effect infection prevalence depends upon pathogen transmission mode host competence scales body size dilution effects detected frequency transmitted pathogens amplification effects detected density dependent pathogens amplification effects also observed particular range habitat loss frequency dependent pathogens assumed host competence greatest large bodied species contrast amplification effects observed density dependent pathogens host competency affected magnitude effect models used guide future empirical studies biodiversity disease relationships across gradients habitat loss type transmission relationship host competence community assembly identity hosts contributing transmission transmission scales area essential factors consider elucidating mechanisms driving disease risk shrinking habitat article part themed issue conservation biodiversity infectious disease scientific evidence policy implications
current broadband satellite systems supporting dvb rcs band static physical layer order complicate implementation however band frequencies adaptive physical layer wherein physical layer parameters dynamically modified per user basis necessary counteract atmospheric attenuation satellite radio resource management rrm medium access control mac layer become important issue given emphasis placed quality service qos provided users work presented tackles problem satellite rrm broadband satellite systems using dvb rcs fully adaptive physical layer envisaged band frequencies impact adaptive physical layer user traffic conditions mac layer functions analyzed algorithm proposed rrm process various physical layer issues associated resource management problem also analyzed
increasingly common encounter materials researchers engaged collaborative analysis transformation large scale scientific data extended periods time scalable system managing tracing exploring communicating analysis diverse scientific data required researchers nowadays dataspaces systems offer pay approach data management offer services data place without losing context surrounding data thus define model architecture virtual dataspaces vds capable addressing requirement automatic construction process virtual dataspaces model vdm described detail effectively organising multi source heterogeneous data resources furthermore dynamic evolution algorithm vds analysed designed timely tracking life cycle data resources system could bring increases facilitating discovery understanding sharing scientific data resources application case field materials engineering described evaluate effectiveness proposed model elsevier rights reserved
decrease live donor pediatric kidney transplants occurred united states study investigates barriers may influence access live donor kidney transplants children retrospective chart review conducted children male mean age years underwent pretransplant workup urban pediatric hospital fifty four percent african american caucasian arabic hispanic others government sponsored insurance medicaid medicare utilized dual caregivers nine kidney transplants live donor transplants live donor transplants significantly lower deceased donor transplants african americans private insurance reported live donor recipients deceased donor recipients among live donor recipients dual caregiver families caregiver health related financial religious cultural barriers live donor transplants reported several may amenable positive intervention
event triggered control aims reducing resource utilization especially communication feedback link guaranteeing certain control performance although setpoint tracking problems common practice majority proposed approaches literature focus regulation problems therefore event triggered control design strategy guaranteed performance proposed paper event triggering condition controller implemented periodically based quadratic cost function control design problem introduced formulated lmi optimization problem comparisons approaches literature made simulation experimental studies demonstrate effectiveness proposed strategy
orientation wayfinding architectural immersive virtual environments ives non trivial accompanying tasks generally support users main task world miniatures wims essentially maps containing scene replica established approach gain survey knowledge virtual world well information user relation however large scale information rich scenes scaling occlusion issues result diminishing returns since typically lack standardized information regarding scene decompositions presenting inside self contained scene extracts challenging therefore present automatic wim generation workflow arbitrary realistic outdoor ives order support users meaningfully selected scaled extracts ive well corresponding context information additionally user interface provided manually manipulate represented extract
cost effective wind turbine diagnosis using supervisory control data acquisition scada data promising technology future intelligent wind farm operation management study presents thermophysics based method drivetrain fault diagnosis synthesised thermal model formed incorporating thermal mechanisms drivetrain system model applications model demonstrated case studies gearbox generator comparing simulation results scada data analysis results show non linearity gearbox oil temperature rise wind speed output power effectively indicate gearbox efficiency degradation may attributed gear transmission problems gear teeth wear electrical generator faults ventilation failure winding voltage unbalance cause changes heat transfer result temperature changes used diagnosis purposes shown different patterns stator winding temperature associated power generation simulation reveals thermal mechanism method applied diagnose failure modes hard identify vibration analysis developed thermal model play central role purpose fault diagnosis deriving relationships various scada signals revealing changes thermophysics operation
social functioning routinely understood disrupted bpd features however little understanding bpd features bpd relevant traits impact social network characteristics time hypothesized bpd features negatively predict social network quality composition rejection sensitivity would affect relations examine sample female college students recruited followed one month bpd features predicted lower ratings social network quality aspects network composition bpd features exerted indirect effect one week perceived levels conflict criticism well number partners network one month follow moderation analyses revealed bpd features predicted lower social network satisfaction support one month high impact satisfaction support low results indicate even non clinical levels bpd psychopathology related poor social network outcomes findings also highlight potential mechanism bpd features predict lower social support satisfaction potential risk factor higher conflict criticism within social networks elsevier ltd rights reserved
objectives study describes women reasons seeking ulipristal acetate upa emergency contraception authorized online retailer upa study design women aged years living states allow prescription medications shipped state accessed kwikmed online pharmacy january december completing medical eligibility screener women answered optional multiple choice questions obtain upa kwikmed individuals must female years age younger currently pregnant breastfeeding attempting order upa within days four times per year results year period kwikmed provided prescriptions upa number women using service tripled time among women responded survey questions response rate sought condom failure use regular contraception half women reported chose upa effectiveness compared levonorgestrel pills preferred ordering upa online found easier getting doctor clinic pharmacy conclusions study documents importance providing confidential services acquiring online benefits online access include convenience less embarrassment avoiding situations provider might refuse provide ideological belief reliable availability time sensitive contraceptive elsevier inc rights reserved
big data analytics recognized one major issues current information society raises several challenges opportunities many fields including economy finance commerce public health administration national security scientific research use visualization techniques make sense large volumes information essential ingredient especially analysis complex interrelated data represented graphs growing availability powerful inexpensive cloud computing services naturally motivates study distributed graph visualization algorithms able scale size large graphs study problem designing distributed visualization algorithm must simple implement whose computing infrastructure require major hardware software investments design implement experiment force directed algorithm giraph popular open source framework distributed computing based vertex centric design paradigm algorithm tested real artificial graphs one million edges experiments show scalability effectiveness technique compared centralized implementation force directed model graphs one million edges drawn minutes spending usd per drawing cloud computing infrastructure amazon published elsevier inc
automated approaches detecting dependencies structures created computer aided design software critical developing robust solvers providing informative user feedback model set geometric constraints colored multigraph give graph based pebble game algorithm allows determine combinatorially generic dependencies use pebble game yield decomposition graph factor graphs may used give user detailed feedback dependent substructures specific realization system cad constraints non generic properties elsevier rights reserved
ambient assisted working aaw discipline aiming provide comfort safety workplace customization technology workers comfort may compromised many labor situations including depending environmental conditions like extremely hot weather conduces heat stress occupational heat stress ohs happens worker uninterrupted physical activity hot environment ohs produce strain body leads discomfort eventually heat illness even death related iso standards contain methods estimate ohs ensure safety health workers subjective impersonal performed posteriori even invasive paper focuses design development real time personalized monitoring effective objective estimation ohs taking account individual user profile fusing data environmental unobtrusive body sensors formulas employed work taken different domains joined method propose based calculations enable continuous surveillance physical activity performance comfortable healthy manner proposal found ohs estimated satisfying following criteria objective personalized situ real time time unobtrusive way enables timely notice workers make decisions based objective information control ohs
even rough literature review reveals many alternative ways implementing binary heap fundamental priority queue structure loved one alternatives best practice opinions crowd pullers textbook authors aligned use array course correct answer depends get opinions facts frameworka set class templateswas written provides variety customization options could used realize large part proposed variants also derived implementations performance benchmarked work three conclusions drawn difficult achieve space efficiency speed time denotes current number values data structure small positive real denotes size values type bytes space efficiency means bytes space speed means lgn worst case time per push pop array based solution sufficient williams original program still day hard beat iii sometimes linked structure clever programming viable option binary heap variant need available software library using reading essay might save headaches copyright john wiley sons ltd
increased attention works education led emphasis developing policy evidence based comparing combining particular statistical summary intervention studies standardised effect size assumed statistical summary provides estimate educational impact interventions combining meta analyses meta meta analyses results precise estimates impact ranked claimed educational policy decisions driven paper demonstrate assumptions false standardised effect size open researcher manipulations violate assumptions required legitimately comparing combining studies restricted circumstances league tables types intervention governments point evidence base effective practice may instead hierarchies openness research design manipulations paper concludes public policy resources danger misdirected
backgroundmaternal symptoms depression related suboptimal parenting practices child well women elevated symptoms tend less responsive children objectivethe objective explore maternal depressive symptomatology related childhood obesity promoting parenting behaviours whether depressive symptomatology moderates association perceived child negativity use food soothe among low income mothers methodsthere cross sectional sample mothers formula fed infants toddlers participating special supplemental woman infants children program measures included infant behaviors questionnaire baby basic needs questionnaire feeding problem assessment form center epidemiological studies depression scale resultsdepressive symptoms exceeded clinical screening cut women mothers depressive symptoms perceived child negative likely use food soothe add cereal bottle put baby bed bottle mothers without depressive symptoms generalized linear models revealed child negativity associated greater use food soothe effect moderated maternal depression negativity positively associated food soothe among non depressed depressed mothers conclusionsa high proportion low income mothers reported elevated depressive symptoms depressive symptomatology positively associated perceived child negativity greater reported use controlling feeding practices screening maternal depressive symptoms may help providing individually tailored counselling responsive feeding
objectivethis study examined barriers accessing three types family planning service emergency contraception termination pregnancy options counselling within grampians region victoria addressing challenges faced geographically marginalised women intention contribute feminist psychological research field women health designthe qualitative study drew community health psychology frameworks community psychology ecological perspective takes account different contexts people lives focus psychosocial aspects women reproductive health behaviour places study health psychology domain settinggrampians region victoria australia participantseleven professionals whose employment connected family planning services victoria interventionssemi structured interviews main outcome measuresthe study documented professionals perceptions facilitators barriers accessing family planning services rural areas implications women psychosocial health ability make timely decisions pregnancy resultsa thematic analysis confirmed women grampians region face many barriers including lack local services privacy misinformation judgmental service providers issues could arise anywhere problem compounded rural areas limited options rural cultural pressures conclusionsthis study highlights complexity many rural women reproductive choices recommends plausible strategies tackle barriers facilitate access family planning services reproductive health research benefit community health psychology perspectives consider psychosocial cultural contexts well biomedical factors
car manufactures combining normal combustion engine electric motor satisfy standards emissions order take advantage technology efficient way example companies car fleets realistic simulation models required paper present accurate yet computationally inexpensive energy demand model microscopic simulation plug hybrid vehicles model mostly consists combustion engine electric motor importantly realistic engine management model furthermore pragmatic kinematic model well model recuperation energy breaking provided modularly designed simulation model allows simple replacement adjustment module input values model requires vehicle speed set constant predefined parameters consequently also enables model easily connected current sophisticated traffic simulators show correctness model regarding consumption fuel electric energy using comprehensive real world experiments
background objectives highly accurate classification biomedical images essential task clinical diagnosis numerous medical diseases identified images traditional image classification methods combined hand crafted image feature descriptors various classifiers able effectively improve accuracy rate meet high requirements classification biomedical images also holds true artificial neural network models directly trained limited biomedical images used training data directly used black box extract deep features based another distant dataset study propose highly reliable accurate end end classifier kinds biomedical images via deep learning transfer learning methods first apply domain transferred deep convolutional neural network building deep model develop overall deep learning architecture based raw pixels original biomedical images using supervised training model need manual design feature space seek effective feature vector classifier segment specific detection object image patches main technological difficulties adoption traditional image classification methods moreover need concerned whether large training sets annotated biomedical images affordable parallel computing resources featuring gpus long times wait training perfect deep model main problems train deep neural networks biomedical image classification observed recent works results utilization simple data augmentation method fast convergence speed algorithm achieve best accuracy rate outstanding classification ability biomedical images evaluated classifier several well known public biomedical datasets compared several state art approaches conclusions propose robust automated end end classifier biomedical images based domain transferred deep convolutional neural network model shows highly reliable accurate performance confirmed several public biomedical image datasets elsevier rights reserved
urban stormwater runoff could negative impacts water resources environment rainwater harvesting rwh serve stormwater control water conservation measure cistern size irrigation scheduling two factors directly impact total runoff residential unit rwh system amount potable water used irrigation effectiveness rwh evaluated four soil types sand sandy loam loamy sand silty clay root zone using three irrigation scheduling methods evapotranspiration based soil moisture based time based five cistern sizes total runoff volumes total supplemental potable water used compared among three irrigation scheduling systems control treatment without rwh model developed simulate daily water balance treatments irrigation runoff volumes compared various scenarios silty clay soil resulted runoff sandy soil sandy soil required average supplemental water silty clay soil average cistern resulted savings water supply reduction total runoff results showed greatest volumes runoff predicted silty clay soil control treatment using time based irrigation scheduling method least volumes calculated sandy loam soil time based irrigation scheduling treatment cistern size greatest volumes total supplemental water predicted sandy loam soil control treatment least volumes silty clay soil based irrigation scheduling treatment cistern size regression equations developed allow users select rwh cistern size based amount water want save runoff reduce
optimal stochastic tracking scheme proposed interactive smart grid infrastructure made three steps utility reshapes customer load profiles scheduling demand response requested customer loads individual smart home makes optimal sequential decisions power purchase optimal stochastic control schemes active power balance primary frequency control designed presence uncertainties arising customer loads distributed renewable generations first two parts addressed previous work paper focus primary frequency control scheme design multilayer control architecture stabilize frequency maintain active power balance within distributed areas propose two stochastic tracking schemes based state space representation synchronous generator reference dynamics based tracking reference statistics based tracking extend proposed optimal controllers considering realistic scenario asynchronous load signals different customers compensate different delays seen different customer signals kalman filter based prediction scheme proposed estimate correct reference signal show centralized reference prediction equivalently implemented distributively simulation results presented showing performances proposed prediction tracking schemes
introduction transbronchial cryobiopsies ctbb emerged new method obtaining lung tissue biopsies diagnosis interstitial lung diseases ilds used highly specialized interventional centers shown promising results obtaining definite diagnosis ilds method patients undergoing ctbb november june included case series study data patient demographics high resolution computed tomography patterns size number biopsies histology patterns contribution confident diagnosis complications registered results thirty eight patients underwent ctbb period ctbb contributed diagnosis patients complications observed pneumothorax frequent complication patients six patients local bleeding occurred procedure easily controlled fogarty catheter balloon cases tranexamic acid conclusion performing ctbb diagnostics ilds safe feasible procedure ctbb resulted confident diagnosis cases
amyloid plaques neurofibrillary tangles nfts brain neuropathological hallmarks alzheimer disease amyloid plaques composed beta amyloid peptides beta nfts contain hyperphosphorylated tau proteins patients familial mutations amyloid precursor protein app gene either increased production beta generate aggregation prone forms beta findings familial mutations app gene suggest beta plays central role pathophysiology beta composed amino acid residues aggregates readily considered form amyloid plaque however processes plaque formation still well known generally thought beta secreted extracellular space aggregates form amyloid plaques beta extracellular aggregates amyloid plaques thought toxic surrounding neurons intraneuronal accumulation beta recently demonstrated reported involved synaptic dysfunction cognitive impairment formation amyloid plaques herein provide overview process intraneuronal accumulation beta plaque formation discuss implications pathology early diagnosis therapy
anorexia nervosa illness frequently begins adolescence involves weight loss two groups adolescent girls weight recovered following healthy comparison completed functional magnetic resonance imaging task involving social evaluations allowing comparison neural activations self evaluations friend evaluations perspective taking self evaluations although two groups different whole brain activations anxiety body shape concerns correlated neural activity priori regions interest cluster medial prefrontal cortex dorsal anterior cingulate correlated body shape questionnaire subjects body shape concerns used area less self friend evaluations cluster medial prefrontal cortex cingulate also correlated anxiety anxiety associated engagement disagreeing rather agreeing social terms self evaluations data suggests differences utilization frontal brain regions social evaluations may contribute anxiety body shape concerns adolescents clinical follow obtained allowing exploration whether brain function early course disease relates illness trajectory adolescents successful recovery used posterior cingulate precuneus friend self evaluations adolescents remained ill suggesting neural differences related social evaluations may provide clinical predictive value utilization mpfc precuneus social self evaluations may key biological component achieving sustained weight recovery adolescents elsevier ltd rights reserved
although known methylnicotinamide mna displays vasoprotective activity mice yet effect mna endothelial function demonstrated vivo using magnetic resonance imaging mri profile effects mna endothelial phenotype mice atherosclerosis apoe ldlr vivo comparison angiotensin ang converting enzyme ace inhibitor perindopril known vasoprotective activity biochemical level analyzed whether mna perindopril induced improvement endothelial function results changes ace ang ace ang balance arginine asymmetric dimethylarginine adma ratio endothelial function permeability evaluated brachiocephalic artery bca month old apoe ldlr mice non treated treated month months either mna day perindopril day intragate flash sequence used evaluation bca volume changes following acetylcholine ach administration relaxation time mapping around bca assess endothelial permeability using intravascular contrast agent activity ace ang ace ang pathways well metabolites arginine adma pathway measured using liquid chromatography mass spectrometry based methods non treated month old apoe ldlr mice ach induced vasoconstriction bca amounted month treatment either mna perindopril resulted reversal impaired ach induced response vasodilatation respectively decrease endothelial permeability mna well perindopril treated mice improvement endothelial function mna perindopril cases associated activation ace ang inhibition ace ang axes evidenced approximately twofold increase ang ang proportional decrease ang active metabolites finally mna perindopril treatment resulted increase arginine adma ratio mna perindopril compared non treated mice functional biochemical endothelial profiling apoe ldlr mice vivo revealed month treatment mna day displayed similar profile vasoprotective effect month treatment perindopril day improvement endothelial function associated beneficial changes ace ang ace ang balance arginine adma ratio plasma
background heterosexual intercourse accounted reported hiv cases guangxi guangxi china total number reported hiv cases older men particularly vulnerable stis example guangxi hiv cases men years age studied population china effective prevention control policies yet developed thus aim study use large scale cross sectional survey understand demographic behavior factors associated hiv syphilis infections among older male clients female sex workers fsws high epidemic area rural guangxi china methods large scale cross sectional survey conducted among older male clients fsws low cost commercial sex venues questionnaire interviews administered collect sociodemographic sexual behavior information blood samples collected hiv syphilis infection tests results participants clients steady sex partner clients steady sex partner overall prevalence hiv syphilis infection respectively compared steady sex partner clients steady partner higher odds hiv infection aor syphilis infection aor factors associated hiv syphilis infection including non commercial casual sex encounters last month aor years commercial sex history aor incidents commercial sex last month aor aphrodisiac use last month aor clients steady partner lower odds heterosexual intercourse aor awareness knowledge hiv aids aor hiv tests aor conclusion older male clients low cost commercial sex venues rural southwestern china high risk hiv syphilis infection especially steady sex partner improved interventions urgently needed neglected risk population
software fault tolerance important issue using software systems safety critical applications systems software robustness essential requirement improving software fault tolerance since operating system major part safety critical system robustness considerable influence system overall robustness recent years researchers emphasized importance considering state robustness testing state determined analysis interactions components paper approach named timeout proposed robustness testing embedded real time oss approach reveals impact time delays inputs invalid timing delay kernel functionality timeout takes state account improves existing robustness testing methods proposed approach implemented experiments performed linux preempt embedded real time implementation linux operating system results show state influence behavior respect fault tolerance presence time delays based results approach system developers identify criticality states improve robustness states
background adherence psychiatric medication critical issue serious individual public health implications secondary analysis large scale clinical treatment trial occurring substance use psychiatric disorder method participants received clinically indicated psychiatric medication days month study provided corresponding data medication event monitoring system mems morisky medication taking adherence scale mmas self report adherence ratings included analyses accuracy mems caps openings customized participant unique required dosing schedule results consistent expectations mems based adherence declined slowly time though mmas scores forgetting medication remained high change month study mems caps openings significantly impacted baseline treatment level variables whereas mmas scores significantly associated younger age presence axis disorder antisocial personality disorder cluster diagnoses conclusions results suggest mems caps may objective method monitoring adherence patients occurring substance use psychiatric disorder relative mmas self report participants study able successfully use mems caps month period lost broken caps suggesting comorbid population able use mems successfully ultimately data suggest objective method monitoring adherence treatment population yield accurate outcomes relative self report elsevier ireland ltd rights reserved
attention deficit hyperactivity disorder adh neuropsychological developmental disorder characterized pervasive impairing symptoms inattention hyperactivity impulsivity whereas well known children still little information adh adults including prevalence indeed actually epidemiological studies france despite considerable impact disorder patient professional affective life moreover adh rarely stays isolated many comorbidities often complicate diagnostic investigation well known called adh composed two main categories symptoms attentional disorder hyperactiviy disorder impulsiveness also remains major symptom objective aim study evaluate prevalence impulse control disorders icd also psychological addictive comorbidities among adult patients adh total patients specialized consultations adult adh evaluated study included presenting clinical criteria adh method used dsm adh minnesota impulsive disorders interview semi structured clinical interview assessing impulse control disorders icd compulsive buying trichotillomania compulsive sexual behaviour kleptomania pyromania intermittent explosive disorder mini international neuropsychiatric interview order evaluate psychiatric addictive comorbidities results patients met early apparition criteria adh years half patients presented mixed type adh inattentive hyperactive impulsive forms inattentive type vast majority patients showed complete form total symptoms inattentive impulsive hyperactivity category presented sub syndromic form adh symptoms least one category regarding icds found proportion patients manifesting least one frequent icd intermittent explosive disorder ied followed compulsive buying pathological gambling kleptomania compulsive sexual behaviour trichotillomania among psychiatric comorbidities evaluated generalized anxiety disorder followed dysthymia major depressive episode agoraphobia panic disorder hypomanic episode social phobia bulimia nervosa antisocial personality disorder obsessive compulsive disorder regarding addictive comorbidities found prevalence substance abuse non alcohol followed alcohol abuse substance dependence non alcohol alcohol dependence conclusion adh adults continues unrecognized france aim study evaluate prevalence impulse control disorders psychiatric addictive comorbidities adults adh results enable appreciate quantitative qualitative data french adults adh disorder rarely remains isolated often associated many others especially anxiety mood disorders also observed impulsivity stays heart adh either impulsive behaviours addictive disorders considering lack studies adh adults difficult compare data diagnosis adh complex stays controversial moreover strong prevalence comorbidities points importance differential diagnosis encephale paris
article responds five comments angry birds meta analysis video game influences children ferguson issue given ongoing debates video game influences comments varied supportive self proclaimed angry yet hopefully response contribute constructive discussion field moves forward reply address misconceptions comments present data challenge assumption standardized regression coefficients invariably unsuitable meta analysis bivariate correlations invariably suitable meta analysis suitability data considered case case basis data indicates coefficients included angry birds meta analysis distort results study selection effect size extraction interpretation improved upon problematic issues recent meta analyses evidence also provided support contention publication bias remains problematic video game literature sources acrimony among scholars explored areas agreement ultimately debates resolved commitment newer rigorous methods open science
spreadsheet applications widely adopted millions end users several application domains provide strategic support many business scientific industrial organizational processes applications usually developed rapid application development processes exploiting host scripting languages allowing basic spreadsheets provide complex functionality business rules user interfaces several factors complicate comprehension applications usually developed maintained end users without specific software engineering skills grow time adequately documented present explicit separation data business logic user interface layers paper presents reverse engineering tool intended support comprehension excel spreadsheet applications developed using visual basic application programming language tool implemented add extends excel working environment providing analysis visualization features able extract information elements composing analyzed excel spreadsheet application functionality exposes user interface dependencies among cells information provided means interactive views validity tool assessed qualitative case study performed professional end users automotive industrial domain copyright john wiley sons ltd
historically male workers comprised large proportion occupational fatalities common explanation men overrepresented physically hazardous occupations yet another potential explanation prescribed gender roles norms contribute higher rates male worker fatalities compared female workers purpose study test assumption overrepresentation explanation first testing degree overrepresentation adequately accounts men women differing fatality frequencies across various occupations second exploring gendered worker occupation organizational attributes may explain variance severity men fatality disparity occupational titles used data bureau labor statistics occupational information network net results indicate total occupational fatalities occurred outside would expected equivalent fatality ratios men women working occupation gendered job worker characteristics significantly predicted variance men relative risk workplace fatalities across occupations characteristics combined sex representation explained total variance men relative fatality risk results suggest men may increased risk occupational fatalities compared women occupations advocate investigating role gender future research injury fatality discrepancies male female workers elsevier ltd rights reserved
interstitial free steel workpieces deformed equal channel angular pressing ecap equivalent strain epsilon epsilon followed flash annealing microstructures analyzed optical microscopy scanning electron microscopy transmission electron microscopy mechanical properties evaluated hardness testing yield strength materials calculated hardness values flash annealing degrees ecaped samples epsilon epsilon results abnormal subgrain growth abnormal grain growth respectively flash annealing degrees ecaped epsilon steel converts abnormally grown subgrains grains serve nuclei recrystallization result bimodal grain size distribution bimodal grain size distribution also produced ecaped steel epsilon flash annealed degrees due abnormal grain growth secondary recrystallization flash annealing steel samples ecaped low epsilon temperature range degrees decreases hardness continuously increase annealing temperature increases high epsilon former due annihilation defects later caused ordering nonequilibrium boundaries hardening strengthening behaviors similar
objectives olanzapine well established treatment schizophrenia olanzapine pamoate depot long acting injectable formulation improves compliance clinical trials shown effective however previously published reports evaluating olanzapine depot violent patients schizophrenia community evaluated clinical efficacy olanzapine depot effect violence hospitalization incarceration community patients schizophrenia prior history serious violence methods retrospective service evaluation community forensic psychiatry service patients schizophrenia spectrum disorder significant history violence treatment resistance substance use disorders antisocial personality disorder common nine deidentified patient records audited months pre months post olanzapine depot initiation identify clinical changes breaches legislated psychiatric treatment orders hospital admission days days incarcerated emergency presentations results community forensic psychiatric patients treated olanzapine depot showed improvement psychotic symptoms overall decreases violence supported reductions hospitalization days days incarcerated several patients reduced psychiatric treatment order breaches emergency presentations conclusions community forensic psychiatric patients schizophrenia responded olanzapine depot decreased violence reduced hostility depot antipsychotic medication reduces violence improves engagement significant implications greater effective community management forensic patients schizophrenia
occupational recreational aquatic activity predisposes population wide variety dermatoses sunburn urticaria jellyfish stings contact dermatitis rubber equipment common allergies encountered aquatic environment among infections tinea versicolor intertrigo verruca vulgaris widespread swimmer itch may occur due skin penetration schistosome cercariae free floating nematocysts marine coelenterates may precipitate seabather eruption suit squeeze due cutaneous barotrauma lymphoedematous peau orange due decompression rare described entities review serves ready reckoner indian dermatologists medical practitioners identify manage conditions
monolayer endothelial cells ecs lining intima blood vessel wall forms semipermeable barrier regulates tissue fluid homeostasis transport nutrients migration blood cells across barrier number signaling pathways molecules mediate endothelial permeability plays important roles variety physiological pathological conditions fatty acid binding proteins fabps able bind various hydrophobic molecules long chain fatty acids prostaglandins eicosanoids fabp member family fabps plays important role maintenance glucose lipid homeostasis well angiogenesis present study found fabpa ortholog mammalian fabp highly expressed developing brain vessels zebrafish knockout fabpa gene caused hemorrhage zebrafish brain morpholino mediated fabpa gene knockdown phenocopied hemorrhage mutants furthermore demonstrated permeability brain vessels fabpa mutant significantly higher control addition cox lox inhibition partially rescued brain vessel integrity defects caused fabpa loss function suggesting integrity defect relevant fatty acid function
background medicare beneficiaries multiple chronic conditions typically seen multiple providers particularly specialists clinically appropriate referrals multiple specialists may compromise continuity care multiple chronic condition beneficiaries create care plans patients may find challenging reconcile may impact patient outcomes objective objective examine whether glycemic control lipid control associated number prescribers cardiometabolic medications research design subjects measures retrospective cross sectional cohort analysis elderly medicare fee service beneficiaries diabetes beneficiaries dyslipidemia living east coast states glycemic control defined hbac lipid control defined low density lipoprotein beneficiaries heart disease diabetes low density lipoprotein beneficiaries examined association number prescribers cardiometabolic medications disease lipid control logistic regression controlling age sex race medicaid enrollment chronic conditions state fixed effects results among beneficiaries diabetes one prescriber well controlled diabetes decreased beneficiaries prescribers adjusted analyses medicare beneficiaries prescribers less likely glycemic control beneficiaries single prescriber among dyslipidemia nearly beneficiaries lipid control adjustment demographics comorbidity burden beneficiaries prescribers less likely lipid control beneficiaries single prescriber conclusions multiple prescribers associated worse disease control possibly patients severe diabetes dyslipidemia multiple prescribers care fragmentation associated worse disease control
design development projects inevitably involve iteration iteration positive effects enabling progressive generation knowledge enabling concurrency integrating necessary changes also increases duration cost project managing iteration thus important issue practice challenging due part profusion issues terminologies article contributes literature summary integrating taxonomy clarify different perspectives iteration brings together insights iteration gained different research communities mainly design product development alongside selected work construction management software project management different research approaches including conceptual frameworks mathematical simulation models case studies surveys protocol studies differentiating issues providing uniform terminology article maps insights developed date may help situate future analyses iterative processes
ability introspectively evaluate experiences form accurate metacognitive beliefs insight essential component decision making previous research suggests individuals vary substantially level insight variation related brain volume function particularly anterior prefrontal cortex apfc however neurobiological mechanisms underlying effects unclear qualitative macroscopic measures brain volume related variety microstructural features leverage high resolution isotropic multi parameter mapping technique healthy individuals delineate quantitative markers vivo histological features underlying metacognitive ability specifically examined neuroimaging markers local grey matter myelination iron content relate insight measured signal theoretic model subjective confidence results revealed pattern microstructural correlates perceptual metacognition apfc precuneus hippocampus visual cortices particular extend previous volumetric findings show right apfc myeloarchitecture positively relates metacognitive insight contrast decreased myelination left hippocampus correlated better metacognitive insight results highlight ability quantitative neuroimaging reveal novel brain behaviour correlates may motivate future research environmental developmental underpinnings
one important tumor suppressor genes direct transcriptional targets must explored elucidate functional mechanisms thus far targets primarily studied protein coding genes previous study revealed several long non coding rnas lncrnas direct transcriptional targets knockdown specific lncrnas modulates induced apoptosis study analysis next generation chromatin immunoprecipitation sequencing chip seq data revealed lncrna neat direct transcriptional target suppression neat induction attenuates inhibitory effect cancer cell growth also modulates gene transactivation including many lncrnas furthermore low expression neat related poor prognosis several cancers results indicate induction neat expression contributes tumor suppressor function suggest neat constitute transcriptional network contributing various biological functions tumor suppression new one important known tumor suppressor genes thus far targets primarily studied protein coding genes recent study revealed long non coding rnas lncrnas may also play important roles carcinogenesis study authors found lncrna neat direct transcriptional target knockdown neat affected gene transactivation enhanced cancer cell growth furthermore low expression neat related poor prognosis several cancers results indicate induction neat expression contributes tumor suppressor function
backgroundfunctional gastrointestinal disorders fgids common diverse group disorders unknown etiology resulting significant socieconomic burden study aimed assess prevalence fgids children aged years examine association various demographic socioeconomic parameters methodsthis school based cross sectional study approved relevant government authorities informed consent obtained legal representatives children participated diagnoses fgids based greek official translation rome iii questionnaire demographic socioeconomic information also collected key resultsa total children females mean age years included overall prevalence fgid common fgids functional constipation abdominal migraine aerophagia irritable bowel syndrome multiple logistic regression analysis probability fgid identified physical exercise exposure victimization gender parental educational level number children home number adults home significant covariates fgid final model conclusions inferencesfgids affect approximately school aged children greece following characteristics associated higher probability fgid female gender living non nuclear household victimization lower parental education level infrequent physical activity high television exposure
article seeks explore relationship among three individual level trait measures masculinity two aspects intimate partner violence ipv physical violence coercive control sample heterosexual men court mandated batterers treatment program results indicate aspects masculinity specifically restrictiveness hostile sexism may contribute use coercively controlling tactics intimate relationships furthermore implications findings suggest failure achieve desired control may lead use physical violence inconsistent past findings limited study clinical populations examination concepts provides increased understanding mechanisms behind ipv perpetration results provide greater understanding complexity violence better assist individuals experiencing ipv
rainwater harvesting presents viable option securing water availability order increase food production study focuses rural youth luphisi dwaleni villages mpumalanga province considers relationship youth capabilities food security study uses qualitative data collected focus group discussions quantitative data baseline survey within context integrated rainwater harvesting project indicators tapped attributes related trust social cohesion inclusion sociability examined within context capability approach consider whether ways attributes linked food security results show youth high levels certain capabilities trust social cohesion inclusion operation self esteem meaning however dimensions fewer opportunities like access networks access knowledge information sociability lacking among youth restrict opportunities engage issues around food water security chi square test used investigate relationship youth capabilities food security results showed relationship youth capabilities food security dwaleni however three capabilities showing significant statistical relationships youth capabilities food security luphisi collective action operation social cohesion self esteem argue opportunities build existing capabilities overall potential youth engaging water resources management tapped
study aims differentiating construction project critical success factors based organizational backgrounds project participants contractor construction manager owner representative design firms construction professionals diverse locales asked rate list potential factors objectives schedule budget quality additionally compare objectives overall project success set factors enriched eliminating factors could prove statistical significance even one schedule budget quality performances three organizations commissioning significant factors analytical hierarchy process used determine organization based factor rankings overall project success spearman test rankings significant factors overall project performance results highest level correlation managers contractor personnel followed managers designers least correlation contractor personnel designers hence successful project implementation professional construction managers edge designers supervising contractors american society civil engineers
equilibrium thermodynamic modelling quartz garnet quig raman geobarometry modelling garnet nucleation overstepped conditions applied three garnet bearing blueschists long transect across eclogite blueschist unit sifnos greece order evaluate accuracy conditions calculated via equilibrium thermodynamics quig barometry uses raman shift quartz inclusions garnet estimate pressure garnet nucleation independent chemical equilibrium garnet nucleation temperatures estimated determining stability field palaeo assemblage inferred garnet inclusion suites mineral assemblage diagrams calculated mnnckfmash system temperatures obtained rutile thermometry conditions compared conditions calculated equilibrium garnet isograd method intersecting isopleths conditions calculated intersecting garnet isopleths underestimated temperature nucleation samples sph sph respectively whereas significantly underestimated nucleation pressure sph nucleation garnet sph kbar similar degrees requires overstepping similar kbar reaction affinity mol sph requires overstepping similar kbar garnet reaction affinities least mol kbar similar degrees sph requires overstepping approximately kbar affinities mol similar kbar similar degrees geotherms calculated sph similar degrees sph degrees accordance previous studies geotherm calculated sph however warmer degrees could reflect changes rate subduction differences structural position within going slab kbar pressure difference sph sph explained thrusting accretion thin slices underplated wedge material facilitated slab rollback gravitational collapse
nonheterosexual individuals half likely heterosexual counterparts report religious identity gay lesbian bisexual queer glbq emerging adults maintain religious identity affiliation throughout adolescent young adult years challenge dominant narratives sexuality religion pew study contextualizes demographic findings considers impact family life sexual identity authors present data qualitative interviews glbq individuals ages results presented model describing participants constructed glbq christian identity perceive acceptance identities families church communities
physiological effects dog assisted stress management communication training program conducted prison investigated assessing salivary cortisol concentrations prison inmates sessions program conducted groups inmates psychiatric developmental disorders program male inmates interacted trained pet dogs volunteer handlers inmates evaluated mood states session using questionnaire moreover handlers evaluated quality interaction inmates session results indicated inmates cortisol values cases decreased following participation sessions inmates demonstrated stress reduction decreasing cortisol values diagnosed psychiatric disorders aware mood improvement evaluated handlers interacted well sessions indicated validity psychiatrists diagnoses inmates self evaluation handlers evaluation inmates also inmates experienced medium mood without mood changes decreased cortisol values suggested results useful predicting selecting inmates expected obtain effects participating program moreover suggested providing feedback inmates changes salivary cortisol levels could help better understand psychophysical state could result effective stress management
work aimed find one two soliton solutions nonlinear tzitzeica dodd bullough tdb equation since double exp function method widely used solve several nonlinear evolution equations mathematical physics also used help symbolic computation solving present equation method seems easier accurate thanks recent developments field symbolic computation
vulnerability segmentation hypothesis proposes plant branches resistant cavitation terminal leaves namely difference vulnerability cavitation branches terminal leaves positive pleaf branch allows leaves act safety valves protect hydraulic pathway dysfunction recent studies showed several species humid regions negative values pleaf branch indicating lack vulnerability segmentation species lvs species hypothesize compared species humid regions vulnerability segmentation critical necessary arid species survive droughts lvs species may take compensatory hydraulic strategies maintain safety margins drought periods compile branch leaf hydraulic trait data broadleaved woody species belonging different biomes contrasting climatic conditions indicated variable aridity index find pleaf branch becomes small even negative increase although leaves lvs species may lose function safety valves deep rooting great hydraulic conductivity high stem capacitance features critical maintain hydraulic safety results indicate vulnerability segmentation evidently common species arid regions necessarily case species humid regions robust cavitation resistant leaves effective hydraulic compensatory strategies lvs species maintain water supply functionality leaves thus giving hydraulic advantage counterparts face potential drought stress available article
design patterns dps acknowledged powerful conceptual tools improve design quality reduce time cost development process effect reuse good design solutions many fields software engineering web engineering interface design patterns widely used practitioners also investigated research perspective still seldom explored arena recommender systems rss rss provide suggestions recommendations items likely appropriate user profile increasingly adopted content intensive multimedia applications complement traditional forms search large information spaces paper explores rss lens user interface design patterns performed systematic analysis recommendation empowered content intensive multimedia applications order discover occurrences existing domain independent patterns identify frequently adopted solutions modelled existing patterns define set new patterns specific interfaces recommendation features others useful also broader context results inspection discussed evaluated team experts leading consolidated set new patterns reported paper reusing pattern based design solutions instead building new solutions scratch enables novice expert designers build good uis recommendation empowered content intensive multimedia applications effectively ultimately improve experience class systems broader perspective work stimulate future research bridging recommender systems web engineering interface design means design patterns highlights new research directions also discussed paper
background purpose purpose study evaluate internal marginal fit chrome cobalt crowns fabricated laser sintering computer aided design cad computer aided manufacturing conventional methods materials methods polyamide master working models designed fabricated models initially designed software application three dimensional cad maya autodesk inc models fabricated models produced printer eosint sls eos unit fixed dental prostheses fabricated four different techniques conventional lost wax method milled wax lost wax method mwlw direct laser metal sintering dlms milled mco cement film thickness marginal internal gaps measured observer using stereomicroscope taking digital photos results best fit rates according mean standard deviations measurements dlms premolar molar models significant difference found dlms rest fabrication techniques significant difference found mco mwlw fabrication techniques premolar molar models conclusion dmls best fitting fabrication techniques single crown based results best fit found marginal larger gap found occlusal groups within clinically acceptable misfit range
electrochemical storage systems increasingly employed stationary automotive applications lithium ion technology nowadays shows best features future development prospects nevertheless lithium ion chemistries lot need know deep behaviour relation final applications among used lithium technologies cnr itae selected two different lithium technologies lithium iron phosphate lifepo lithium polymers tested compared indeed several electrical vehicles developers electrical network operators choosing specific chemistries safety relatively low cost flexibility creating customized battery pack paper reports results several tests carried order investigate features battery technology stationary automotive applications particular capacity reduction peukert effect cell efficiency analysed furthermore tests showed different relax time effect dynamic behaviour cells subjected different load profiles compliant iec international electrotechnical commission tests procedures final analysis carried comparing main performance indicators capacity amperometric energetic efficiency working temperatures etc elsevier ltd rights reserved
need understand proffer sustainable solutions persistent energy crises energy starvation nigeria even face abundant endowment renewable fossil energy resources motivated study study justified solar energy accorded highest priority energy source nigeria globally detailed review past current future status solar integration nigeria presented seen grid connected solar power integration past status nil current status nil future status may completely bleak number memoranda understanding signed existing supportive solar energy policies highlighted disdussed chasm commendable nigeria policy landscape near zero status solar integration blamed poor implementation existing provisions government recommendations made basis existing policies proposed policies additional provisions existing laws federation accommodate support solar energy integration suggested recommended poor incipient status solar integration vastly populated nigeria viewed positive light potential foreign investors status guarantee solar power thermal industry first hand investment opportunity
nowadays container virtualization lightweight alternative hypervisor based approach recent improvements linux kernel allow execute containers smart objects single board computers running linux based operating systems considering several iot application scenarios crucial rely cloud services able deploy customize pieces software running target smart objects achieve goal paper focus attention message oriented middleware cloud monc system designed compose cloud facilities means flexible federation enabled communication system objective provide internet things iot services complex smart environment smart city smart objects interact others cloud infrastructure specifically discuss momc extended support container virtualization linux embedded devices order easily deploy iot applications flexible fashion present design related software modules
paper power system automatic generation control agc two contiguous areas studied demonstrate speed deviation generator due photovoltaic power fluctuation time frequency domains system linearized modeled state space representation change power defined input system change speed deviation defined output system analysis using unit step function input illustrates increased change power affect speed deviation generators changed power another side lower overshoot change speed deviation study area moreover system excited sinusoidal waveform input signal imposed signal scaled solar irradiance data respectively case using sinusoidal waveform input results show magnitude change speed deviation function amplitude frequency function biasing case system inputted using scaled solar datasets changes speed deviation arc observed power fluctuation occurs
researchers different fields involved human behavior analysis last years successful recognition human activities video analysis still challenging problem within context applications targeting elderly care considerable interest public industrial bodies especially considering aging society living ambient intelligence ami technologies intended possibility automatically detecting reacting status environment persons probably major enabling factor ami technologies require suitable networks sensors actuators well adequate processing communication technologies paper propose innovative solution based real time analysis video application field elderly care system performs anomaly detection proposes automatic reconfiguration camera network better monitoring ongoing event developed framework tested publicly available dataset also deployed evaluated real environment
edge detection integral component image processing enhance clarity edges image detection edges image may help image segmentation data compression image reconstruction edges image considered type crucial information extracted applying detectors different methodologies main purpose simplify image data order minimize amount data processed exist many rich classical edge detection techniques make use integer order differentiation operators function spatial frequency domains case integer order differentiation operators gradient operator identified order one laplacian order two paper demonstrates new kind edge detector based fractional non integer order differentiation operation usage fractional fourier transformation tool perform fractional fourier frequency domain known edge detection based fractional signal processing approach shown computer simulations approach detect edges precisely efficiently finally performance proposed methodology illustrated quantitative aspects mean square error peak signal noise ratio simulations experiments show grayscale image method obtain better edge detection performance satisfy human visual sense moreover comparisons also provided prove proposed method outperforms classical edge detection operators interpreted terms robustness noise
bloom syndrome rare recessive disorder characterized loss function mutations blm gene encodes recq dna helicase despite putative tumor suppressor function contribution blm human sporadic colorectal cancer crc remains poorly understood transcriptional regulation mechanism underlying blm related dna damage response regulation independent crc subsets panel derived cell lines investigated bioinformatics analysis transcriptomic profile cpg island promoter methylation assay western blot immunolocalization assay silico analysis gene expression data sets revealed blm overexpressed poorly differentiated crc exhibits close connection shorter relapse free survival even adjustment prognostic factors pathways respond dna damage response ataxia telangiectasia mutated atm signaling functional characterization demonstrated cpg island promoter hypomethylation increases blm expression associates cytoplasmic blm mislocalization increased dna damage response clinical crc samples derived cancer cell lines dna damaging agent adenosylmethionine suppresses blm expression leading inhibition cell growth following accumulation dna damage tumor specimens cytoplasmic accumulation blm correlates dna damage gamma hax phosphorylated atm foci predicts long term progression free survival metastatic patients treated irinotecan taken together findings study provide first evidence cancer linked dna hypomethylation cytosolic blm mislocalization might reflect compromised levels dna repair activity enhanced hypersensitivity dna damaging agents crc patients
performance efficiency emissions internal combustion engines affected thermo viscous boundary layer region heat transfer computational models prediction engine performance typically rely equilibrium wall function models overcome need resolving viscous boundary layer structure wall shear stress heat flux obtained boundary conditions outer flow calculation however equilibrium wall function models typically derived considering canonical flow configurations introducing substantial modeling assumptions necessarily justified cylinder flows objective work assess validity several model approximations commonly introduced development wall function models engine applications examination performed considering crank angle resolved high resolution micro particle image velocimetry piv measurements spark ignition direct injection single cylinder engine using measurements performance algebraic equilibrium wall function model commonly used rans les engine simulations evaluated identifying shortcomings model non equilibrium differential wall model developed two different closures considered determination turbulent viscosity shown wall models provide adequate predictions applied inside viscous sublayer however equilibrium wall function model consistently underpredicts shear stress applied log layer contrast non equilibrium wall model provides improved predictions near wall region shear stress irrespective wall distance piston location utilizing experimental data significant adverse pressure gradients due large vortical motion inside cylinder induced tumble swirl turbulence observed included non equilibrium wall model improve model performance investigations complemented developing consistent wall heat transfer model simulation results compared equilibrium wall function model woschni empirical correlation
background chinese psychiatrists gradually started focus deemed clinical high risk chr psychosis however still unknown often individuals identified chr different country background previously studied would transition psychosis objectives study examine baseline characteristics timing symptom onset help seeking transition psychosis year period china method presence chr determined structured interview prodromal syndromes sips participants first visit mental health services total chr participants completed clinical follow least years conversion determined using criteria presence psychotic symptoms sips analyses examined baseline demographic clinical predictors psychosis trajectory symptoms time survival analysis kaplan meier methods along log rank tests performed illustrate relationship baseline data either conversion non conversion time cox regression performed identify baseline predictors conversion year follow results total completers transitioned psychotic disorder course follow among chr sample mean time attenuated symptom onset professional help seeking months average converters developed fully psychotic symptoms months symptom onset compared chr participants whose risk syndromes remitted course study converters significantly longer delays first visit professional search help baseline assessment conversion subgroup younger poorer functioning higher total sips positive symptom scores longer duration untreated prodromal symptoms often given psychosis related diagnoses subsequently prescribed antipsychotics clinic conclusions chinese chr identified primarily novel clinical screening approach year transition rate comparable specialised help seeking samples world wide early clinical intervention functionally deteriorating clinical population suffering attenuated psychotic symptoms next step applying chr construct china
novel vacuum ice slurry producing system jet pumps proposed deal problems high energy consumption ice blockage novel system one steam driven jet pump used create vacuum hermetic vessel water sprayed nozzle produce ice slurry steam used provide enough cold energy make left vapor hermetic vessel condense mathematical models novel system established theoretical simulation performance characteristics also implemented based matlab program results show novel system feasible practicable system performance affected many factors temperature generators condensing temperature evaporation temperature cooling load refrigerator sub system findings helpful improve performance ice slurry producing system
background malassezia commensal yeasts along multitude antigens found associated various skin disorders including pityriasis versicolor amongst mala kda protein proved major allergen reacting large panel sera however exists therapeutic alternative combat problems form plant based natural compounds purpose study first place determine anti molossezio activity nyctanthes arbor tristis nat ethanolic leaf extract turbidimetric growth curves disruption plasma membrane secondly aims present silico validation active constituents mala novel allergen methods antifungal susceptibility ethanolic extract nat determined broth microdilution method according clsi guidelines mics determined spectrophotometrically using software softmax pro molecular devices usa active constituents mediated disruption plasma membrane studied flowcytometry permeabilization fluorescent dye propidium iodide antioxidant activity extract determined using dpph stable radical molecular validation fungal dna extract observed using pcr amplification silico analysis active constituents mala performed using hex software visualized pymol results anti maiassezio potential nat leaf extracts reflected moderate mic globosa least effective restricta mic linear correlation coefficient obtained case globosa minimum observed restricta flow cytometric data reveal similar cell death treated active constituents beta sitosterol calceolarioside docking confirmations interaction energies mala active constituents beta sitosterol calceolarioside extracts showed effective binding suggests mala efficient allergen site specific targeting conclusions study revealed nyctanthes arbor tristis nat extracts possess high anti malassezia potential driven mainly disruption plasma membrane also silico validation molecular modeling studies establishes mala novel allergen could potential target disease treatment results would also provide foundation development new therapeutic approach using nat extract lead compound high antioxidant property added trait skin care
aim work model behavior verbal nonverbal behavior pedagogical agent integrated intelligent tutoring system following research questions posed nonverbal component educational communication study component computational model plausible behavior virtual agent correlations educational actions direction gaze human agent carry exploratory work methodological approach based multi modal video corpus study adopted within multidisciplinary team consisting computer scientists didactics mathematics educational situation virtual pedagogical agent likely developed dyadic interactions teachers learners late second early third years skills assessment interview mathematics following resolution exercises students mathematics software filmed multi level annotation scheme annotate observed behavior proposed multidisciplinary research subject human machine interfaces educational sciences educational linguistic etc due development coding scheme delicate important work given wealth knowledge different disciplines portion collected work annotation corpus statistical measures derived annotations carried suggest different strategies teachers terms gaze direction depending learner profile pedagogical actions measures enabled extract rules control nonverbal behavior
double rotator structure ternary optical processor drstop two characteristics namely giant data bits parallel computing reconfigurable processor handle thousands data bits parallel run much faster computers optical computer systems far order put drstop practical application paper established series methods namely task classification method data bits allocation method control information generation method control information formatting sending method decoded results obtaining method methods form control mechanism drstop control mechanism makes drstop become automated computing platform compared traditional calculation tools drstop computing platform ease contradiction high energy consumption big data computing due greatly reducing cost communications finally paper designed set experiments drstop control mechanism verify feasibility correctness experimental results showed control mechanism correct feasible efficient
based theory parents higher levels self efficacy pse find easier parent effectively face challenging child behaviors parents lower levels pse study examines link pse parenting using children behaviors potential moderators participants parents older adolescent age addition target adolescent age adolescents externalizing behaviors used moderators link pse parenting target adolescent path analysis mplus showed higher pse linked promotive parenting among parents older adolescent lower levels externalizing behaviors among parents adolescents higher levels externalizing behaviors whose promotive parenting significantly lower parents overall pse predict promotive parenting link pse parenting differ depending target adolescents behavior findings suggest link parents beliefs parenting depends broader family context specifically pse linked parenting practices depends least partly experiences parents bring parenting older adolescent interactions later born adolescent clinical perspective parents might need guidance think earlier parenting experiences parenting younger adolescent
aim paper provide alternative efficient screening test allergy respect traditional unicap prick skin tests commercially available nowadays proposed test aimed monitoring interaction ige protein allergen allergic subject idea relies fact interaction ige corresponding allergen happens binding mechanisms ige allergen structure changing ionic content serum latter monitored impedance measurements confirmed reactive oxygen species ros evaluation leukocyte subpopulations therefore paper propose novel system detection allergies based impedance measurements confirmed ros measurements type measurement approach never presented literature purpose measurement protocol developed guarantee reproducibility repeatability assay paper describes instrument specifically designed impedance evaluation measurement protocols methodologies defining univocally way overall measurement technique
study design prospective cohort objectives examine relationship summer training practices risk injury first month high school interscholastic cross country season background several prospective studies reported high incidence injury adolescent cross country runners however limited reports exist role summer training practices risk injury among runners methods four hundred twenty one athletes girls boys competed interscholastic cross country followed cross country season start season participants completed questionnaire regarding summer training routines time loss running related injuries tracked subsequent season logistic regression analysis used estimate odds ratios ors confidence intervals cis risk initial injury first month season associated summer training variables results sixty seven runners confirmed injury first month season higher percent among girls boys overall participants ran summer prior season significantly higher percent among girls boys overall significant association found running sometime preceding summer increased risk initial injury first month season among runners ran summer adjusting sex prior injury first month injuries common among frequently alternate short long mileage different days ran weeks fewer summer training running weeks fewer frequently alternating mileage different days running higher percentage time predominantly hill irregular terrains associated increased risk injury girls conclusion findings suggest injuries first month high school cross country season may reduced runners participate summer training activities run greater number weeks frequently vary daily running mileage summer girls training programs reduce mileage hills irregular terrains may help minimize occurrence running related injury
previous research documented sex differences nonverbal communication remained unknown whether similar sex differences would exist regard olfactory communication via chemosignals relatively neglected nonverbal communication medium women generally better sense smell greater sensitivity emotional signals hypothesized compared male participants relative neutral control condition female participants would emulate fearful state sender producing chemosignals facial electromyography used double blind experiment measure receiver partial reproduction state sender controlling moderating influence sex sender receiver results indicated female participants emulated fearful state sender present study revealed boundary condition effective chemosignaling reporting behavioral evidence sexual asymmetry olfactory communication via chemosignals
sleep problems boost inflammation may jeopardize interpersonal functioning risks may magnified couples observational study examined effects self reported recent sleep duration couples inflammation inflammatory responses problem discussion interpersonal behavior use emotion regulation strategies emotion expression cognitive reappraisal conflict people slept less higher stimulated interleukin tumor necrosis factor alpha tnf alpha production marital problem discussion slept however using emotion expression cognitive reappraisal strategies conflict protected couples slept less inflammatory reactivity specifically people short sleep relate inflammatory increases expressed feelings partner reappraised expressed emotions partners slept less couples interacted hostile way least one partner slept data point combination short sleep marital conflict novel path heightened inflammation risk partners emotion regulation strategies may counteract study also highlights role short sleep negative punishing marital behavior elsevier ltd rights reserved
hereditary angioedema disease congenital deficiency functional defect esterase inhibitor inh consequent mutation serping gene encodes inh disease manifests recurrent non pitting non pruritic subcutaneous submucosal edema well erythematous rash cases symptoms result uncontrolled localized production bradykinin commonly affected sites extremities face gastrointestinal tract respiratory system respiratory system affected hereditary angioedema swelling airway restrict breathing lead life threatening obstruction herein report case year old woman type hereditary angioedema presented recurrent episodic abdominal pain swelling extremities family history angioedema although level markedly decreased normal range presented high inh level normal range abnormally low inh activity less normal range serping gene mutation confirmed patient treated prophylactic tranexamic acid needed subsequently reported fewer less severe episodes knowledge first reported case type hereditary angioedema korea consequent serping mutation involved significantly elevated level inh well low level inh activity
research interference influence intentional emi iemi electrical network important assure working reliability paper propagation model disturbances electrical network consists galvanically connected systems wireless systems established based transmission line theory baum liu tesche blt equation approach propagation model straight forward analytical approach applied certain network responses voltages electrical fields obtained load galvanic wireless located network response proportions galvanic wireless parts presented
new framework representation signal processing considers multi domain information flow signal proposed elementary information processing diagrams identified analyze components algorithm translated diagram intra extra domain relationships represented graphs connect corresponding domains suitable mappings transforms corresponding emissions absorption information various examples convolution wavelet filtering projection imaging coding noisy channel presented show ubiquity illustrate usability proposed framework
indian hedgehog ihh widely recognized essential factor proper skeletal development previous vivo studies using mutant ihh mouse models limited perinatal lethality carried growth plate formed thus important role ihh mesenchymal cell differentiation investigated study established prx cre ihh mice ablate ihh specifically limb mesenchyme allow observe phenotype continuously prenatal development weeks age mutant mice displayed severe limb abnormalities characterized complete lack secondary ossification center growth plate indicating essential role ihh development structures interestingly discovered osteoblast differentiation bone formation could occur conditions deficient ihh novel finding observed early lethality previous ihh mutants mature osteoblasts expressing osteocalcin could detected center mutant bones postnatal day osteoclasts blood vessel formation also present suggesting active bone remodeling histomorphometric analyses show significant increase osteoclast number major changes bone formation rate weeks age mutant long bones limbs deformed cortices comprised irregular woven bone also marked decrease gene expression osteoblastic osteocytic markers moreover mutant long bones displayed bone dysplasia observed increased osteoclast activity partially reduced osteoblastic osteocytic differentiation lead ultimately loss bone structures weeks age summary data show first time presence mature osteoblasts long bones limbs despite complete loss growth plate formation due ihh deficiency data indicate important function ihh regulating limb mesenchymal cell differentiation american society bone mineral research
satellite radio posed new question canadian policy makers take advantage transnational radio service ensuring cultural identity lost within channel offerings predominately american comparing initial licensing satellite radio canada merger services post merger license renewal highlights shift spatial understanding satellite radio determined satellite footprint call cultural lifelines various mobile devices services enable one maintain connection cultural content alongside shifting spatial considerations satellite radio canadian content increasingly packaged brand genre catering fragmented taste preferences individual mobile listening practices
tobacco alcohol use linked behaviors individually synergistically increase risk negative health consequences study two group randomized clinical trial evaluating efficacy behavioral intervention motivation problem solving plus maps designed concurrently address smoking cessation reduction risk drinking targeted interventions may promote coaction likelihood changing one behavior smoking increases probability changing another behavior alcohol use puerto ricans smokers risk drinkers randomized standard mapstreatment focused exclusively smoking cessation saviaps maps focused cessation risk drinking reduction drinking outcomes included number risk drinking behaviors heavy drinking binge drinking drinking driving maps significant main effect reducing risk drinking relative maps among individuals quit smoking maps reduced number drinking behaviors likelihood meeting criteria heavy drinking relative maps appeared promising reducing binge drinking maps improve drinking outcomes among individuals unsuccessful quitting smoking maps showed promise reducing risk drinking among puerto rican smokers successfully quit smoking consistent treatment enhanced coaction integrating alcohol intervention cessation treatment reduce engagement treatment hinder cessation outcomes positively impacted risk drinking among individuals quit smoking findings coaction smoking drinking speak promise multiple health behavior change interventions substance use treatment chronic disease prevention published elsevier ltd
intangible nature service delivery means human element relevant role achieving excellence therefore satisfaction company employees perceptions influences process objective study analyze level job satisfaction distributive justice perception professionals working food beverage industry business hotels downtown florianopolis brazil exploratory descriptive study based quantitative approach used data collection instruments consisting job satisfaction scale distributive justice perception validated siqueira addition questionnaire survey profile participants sample intentional non probabilistic chosen according accessibility location adequacy hotels study objectives study conducted ninety two participants working seven hotels data compiled analyzed descriptive statistics inferential tests using spss main results showed level job satisfaction neutral employees less satisfied salaries satisfied management correlation positive concluding possible improve job satisfaction medium long term applying several key measures results allowed array practical interventions improve quality life employees noted study results infrastructure played important role perceptions satisfaction especially regard kitchen employees another regarding workload stress management enhancing sense belonging company also identified critical managerial responsibility social gatherings integration programs non monetary benefits thought important improving satisfaction company employees
objective purpose study examine associations among parental knowledge beliefs healthy sleep sleep practices insufficient sleep pediatric primary care clinic sample methods convenience sample caregivers patients months years attending hospital based pediatric primary care clinic academic center completed brief survey child sleep habits basic sleep knowledge beliefs attitudes regarding sleep health behavior results analyzable surveys response rate mean age index child years children consistent bedtime bedtime later television bedroom frequently fell asleep adult present daily caffeine intake although parents underestimated child sleep needs compared recommended amounts reported child getting adequate sleep half parents believed inadequate sleep increases risk underweight endorsed snoring sign healthy sleep increased level sleep knowledge associated number positive sleep practices inversely correlated sleep duration conclusion results study document need increased targeted caregiver education regarding healthy sleep practices importance adequate sleep impact insufficient sleep health recognition potential signs sleep problems young children especially high risk populations
paper presents sensitivity reliability analysis self anchored suspension bridge applying new hybrid method proposed authors based integration latin hypercube sampling technique lhs artificial neural network ann first order reliability method form pearson linear correlation coefficient plcc monte carlo simulation important sampling technique mcs framework consists three stages analysis selection training validation test datasets establishing ann model lhs technique formulation performance function well trained ann model sensitivity analysis using plcc identification probabilistic failure point based form estimation failure probability using mcs technique upon demonstration efficiency analysis story frame structure method applied sensitivity reliability analysis jiangxinzhou bridge five span self anchored suspension bridge structural parameters external loads considered random variables analysis identified number structural parameters well external loads significant influence structural serviceability safety american society civil engineers
janus kinase jak calreticulin calr constitute two frequent mutations essential thrombocythemia reported mutually exclusive hence examined cohort myeloproliferative neoplasm mpn patients without bcr abl rearrangement additional patients coexistence jak calr mutations frequency calr mutations mpn patients primary myelofibrosis polycythemia vera jak calr mutations coexisted patients clinical characteristics progression free survival pfs elapsed time achieve partial remission across groups jak calr jak calr jak calr jak calr reviewed jak calr group higher leukocyte counts hemoglobin levels frequent thrombotic events jak calr group jak mutations greater effect disease phenotype clinical features mpn patients rather calr mutation jak groups showed tendency poor pfs jak groups regardless calr mutation calr predictor late response treatment study also showed thrombosis frequent patients type calr mutations type calr mutations
study combined theoretical experimental numerical analysis investigate vibration characteristics thin rectangular plate positioned horizontally bottom rectangular container filled liquid flow field pressure derived using equation governing behavior incompressible fluids analytic solutions vibrations thin plate air served fundamental function thin plate coupled liquid used liquid pressure plane deflection thin plate construction frequency response functions analysis vibration characteristics liquid plate coupling system two experimental methods employed measure vibration characteristics thin plate immersed water first involved using sensors polyvinylidene difluoride pvdf measure transient signals fluid plate system subjected impact thin plate converted frequency domain order obtain resonant frequencies fluid plate coupling system second method amplitude fluctuation electronic speckle pattern interferometry espi used measure dynamic characteristics thin plate flow field method paired image processing techniques temporal speckle pattern interferometry tspi temporal standard deviation tstd obtain clear mode shapes thin plate resonant frequencies comparison results theoretical analysis finite element method experimental measurements confirmed accuracy theoretical analysis superior conventional approach based beam mode shape functions experimental methods proposed study used measure resonant frequencies underwater thin plates clear mode shapes obtained using espi results indicate resonant frequencies thin plates underwater lower air limited extent increasing depth water enhanced reduction resonant frequencies elsevier ltd rights reserved
meet increasing requirements hci researchers looking using liquid based materials hydrogels create novel interfaces present design strategy hci researchers build customize liquid based smart material printing platform shelf easy machine parts hardware suggest magnetic assembly based modular design modularized parts easily precisely reconfigured shelf easy machine parts meet different processing requirements mechanical mixing chemical reaction light activation solution vaporization addition xprint supports open source highly customizable software design simulation platform applicable simulating facilitating smart material constructions furthermore compared inkjet pneumatic syringe based printing systems xprint large range printable materials synthesized polymers natural micro organism living cells printing resolution droplet size paper introduce system design detail three use cases demonstrate material variability customizability users different demands designers scientific researchers artists
actuation systems lower limbs exoskeletons extensively investigated presently great effort aimed reducing weight improving efficiency thus increasing operating range battery operated devices work innovative efficient actuation system power knee joint proposed key nonconventional elements alternative design flywheel micro infinitely variable transmission ivt particular powertrain configuration permits exploit efficiently dynamics human locomotion offers possibility recover energy means simulations level ground walking running demonstrated storing energy flywheel permits reduce energy consumption downsize electric motor
compared loss gain communication years children later diagnosed autism spectrum disorder language impairment children typical language development years participants selected prospective population cohort study child language early language victoria study parent completed communication tools used group children autism spectrum disorder demonstrated slower median skill gain increasing gap trajectories compared children typical development language impairment proportion groups lost skills least one domain autism spectrum disorder language impairment typical development children autism spectrum disorder losing skills one domain autism spectrum disorder language impairment typical development loss common groups domain emotion eye gaze higher proportion children autism spectrum disorder language impairment typical development higher proportion children autism spectrum disorder also lost skills gesture sounds understanding compared children typical development language impairment findings add understanding early communication development highlight loss unique autism spectrum disorder
big data one referred key words recent information communications technology industry new generation distributed computing platform cloud environments offer high efficiency low cost data intensive storage computation big data applications cloud resources services available pay mode brings extraordinary flexibility cost effectiveness well minimal investments computing infrastructure however advantages come pricepeople longer direct control data based view data security becomes major concern adoption cloud computing authenticated key exchange essential security system based high efficiency symmetric key encryptions virtualisation technology applied existing key exchange schemes internet key exchange become time consuming directly deployed cloud computing environment especially large scale tasks involve intensive user cloud interactions scheduling data auditing paper propose novel hierarchical key exchange scheme namely hierarchical key exchange big data cloud aims providing efficient security aware scheduling auditing cloud environments novel key exchange scheme developed two phase layer layer iterative key exchange strategy achieve efficient authenticated key exchange without sacrificing level data security theoretical analysis experimental results demonstrate deployed cloud environments diverse server layouts efficiency proposed scheme dramatically superior predecessors cloud computing background key exchange internet key exchange schemes copyright john wiley sons ltd
objective temperament personality bipolar patients studied temperament personality patients comorbid adult attention deficit hyperactivity disorder adhd studied aim study determine effect adhd temperament personality patients remission methods patients disorder diagnosis female male matched control group known psychiatric illness female male according age sex education recruited consecutive admissions sociodemographic form scid childhood adult adhd axis diagnoses according dsm criteria scid applied patients control group patients interviewed presence history current adult childhood adhd diagnosis subjects also completed adult add adhd dsm based diagnostic screening rating scale turkish version turkish version temps scale results adult adhd diagnosis observed bipolar patients control group tempera ment measurements revealed depressive type found commonly pure comorbid adult adhd group compared pure control group severe depressive temperament pure control group comorbid adult adhd group analysed separately depressive temperament difference pure comorbid adult adhd group comorbid adult adhd group observed moderate severe episodes earlier longer maintenance treatment periods three groups differ terms personality disorder antisocial personality disorder schizotypal personality disorder observed comorbid adult adhd group conclusion disorder comorbid adult adhd significant clinical implications may relate personality disorder may due influence adhd disorder
disrupted schizophrenia disc candidate gene psychiatric diseases plays various roles brain development reported candidate gene alzheimer disease recent large genome wide association study caucasians explore associations disc performed case control study including subjects northern han chinese found one single nucleotide polymorphism associated risk late onset alzheimer disease load northern han chinese population association detected load conclusion disc increased risk load northern han chinese population
present public key encryption scheme relational databases pkde allows owner control execution cross relation joins outsourced server scheme allows anyone deposit encrypted records database server thereafter database owner may authorize server join two relations identify matching records across preventing self joins would reveal information records unmatched join security construction formally proved random oracle model based computational bilinear diffie hellman assumption specifically relation joined encrypted records enjoy indistinguishability adaptively chosen ciphertext attacks cca security join scheme offers one way cca security protection records pkde construction shown outperform existing work security guarantee efficiency
control system moving mirror scanning important part fourier transform spectrometer dynamic static performance determines interference effect spectral resolution spectrometer meet requirement uniform velocity moving mirror scanning completely digital control scheme proposed fpga key hardware scheme applied moving mirror movement spectrometer according need current detection velocity detection dual closed loop control composed current loop velocity loop realized current loop velocity loop using control fuzzy pid control respectively experiment results show current curve smooth uniform scan phase moving mirror peak current acceleration deceleration period additionally angular velocity moving mirror uniform section maximum relative error less research results drawn digital control strategy significantly improve velocity stability moving mirror meet performance requirements control system elsevier gmbh rights reserved
introduction women familial cancer syndromes hereditary breast ovarian cancer syndrome brca brca lynch syndrome significantly increased risk developing ovarian cancer advised undergo prophylactic removal ovaries fallopian tubes age years childbearing complete methods comprehensive literature search studies risk reducing salpingo oophorectomy rrso sexuality associated issues conducted medline databases results risk reducing salpingo oophorectomy significantly impact woman psychological sexual well women wishing received information prior undergoing surgery commonly reported sexual symptoms experienced vaginal dryness reduced libido women premenopausal time surgery may experience greater decline sexual function menopausal hormone therapy improving alleviating sexual symptoms pharmacological treatments including testosterone patches flibanserin available limited safety data group conclusions despite high rates sexual difficulties rrso patient satisfaction decision undergo surgery remains high preoperative counseling women considering rrso include discussion potential sexual effects limitations menopausal hormone therapy managing symptoms surgical menopause
java programming lot colleges universities set computer programming language courses programming capability measure level expertise computer java language tool measure ability improve students ability grasp java language lot subject teacher research paper task driven approach object task driven teaching introduce java programming course
method presented duarte mota avellar search first order invariants second order ordinary differential equation odes makes use called darboux polynomials main difficulty involved process determination darboux polynomials computationally expensive introduce optional argument main routine enables shortcut calculations use function associated ode
amygdala one extensively studied human brain regions undisputedly plays central role many psychiatric disorders however outstanding question whether connectivity amygdala subregions specifically centromedial laterobasal superficial nuclei modulated brain state task rest using multimodal approach directly compared meta analytic connectivity modeling macm specific activation likelihood estimation scale derived estimates task based activation functional connectivity nuclei assessed resting state fmri fmri finally using preexisting resting state functional connectivity derived cortical parcellation examined macm fmri amygdala subregion connectivity large scale networks explicitly address amygdala interacts large scale neural networks analyses revealed strong differentiation connectivity patterns brain regions task dependent task independent contexts three regions however showed convergent connectivity right ventrolateral prefrontal cortex vlpfc driven high base rate levels activation similar patterns connectivity across fmri macm observed subregion suggesting similar network architecture amygdala connectivity rest brain across tasks resting state subregion may modified context specific task demands findings support animal models posit parallel model amygdala functioning importantly also modify position suggest integrative processing amygdala
objective study aimed investigate correlation impulsiveness antisocial personality disorder among short term prisoners method impulsiveness diagnosed barratt impulsiveness scale bis results short term prisoners antisocial personality disorder scored significant higher marks bis total scale without personality disorder detail scored higher marks subscale regarding attentional motor nonplanning impulsiveness moderate high effects calculated conclusion considered regard impulsivity conceptual component antisociality
purpose review seizure prediction made important advances last decade recent demonstration prospective seizure prediction possible though remain significant obstacles broader application review describe insights gained long term trials aim identifying research goals next decade recent findings unexpected results studies including strong highly individual relationships spikes seizures diurnal patterns seizure activity coexistence different seizure populations within individual patients exhibiting distinctive dynamics caused evaluate many prior assumptions seizure prediction studies suggest alternative strategies could employed search algorithms providing greater clinical utility advances analytical approaches particularly deep learning techniques harbour great promise combination less invasive systems sufficiently powerefficient computational capacity bring broader clinical application within reach summary conclude review exercise wishful thinking asks ideal seizure prediction dataset would look like data manipulated maximize benefits patients motivation structuring review way create forward looking optimistic critique existing methodologies
paradoxical tensions become salient organizations time ambidexterity paradox studies thus far primarily focused tensions inside organizations managed rendered salient actors using longitudinal embedded case study four strategic business units within media organization theorize role top management team leader practices enabling tensions become salient respective lower level managers initial differences tensions interpreted across levels findings extend dynamic equilibrium model organizing adding interpretive context enabling condition shapes emergence salience provision constellation cues guide sensemaking informed practice based perspective paradox also contribute conceptual model leadership practice outline implications ambidexterity studies
flight dynamics handling qualities flexible aircraft analysed within cranfield aircraft accelerated loads model framework modelling techniques methods used develop framework presented aerodynamic surfaces modelled using modified strip theory mst state space representation model unsteady aerodynamics modal approach structural flexibility mode influence structure deflections analysed supplement general overview framework equations motion models atmosphere gravity fuselage engines introduced general transport aircraft model analysed example framework capabilities results showed according gibson dropback criterion aircraft control system lacks stability longitudinal handling qualities unsatisfactory finally steps future developments framework listed within conclusions
paper investigates reduction dynamic power streaming applications yielded asynchronous dataflow designs using clock gating techniques streaming applications constitute broad class computing algorithms areas signal processing digital media coding cryptography video analytics network routing packet processing etc paper introduces set techniques considering dynamic streaming behavior algorithms achieve power savings selectively switching parts circuits temporarily inactive techniques independent semantic application applied application integrated synthesis stage high level dataflow design flow experimental results size applications synthesized field programmable gate arrays platforms demonstrate power reductions achievable loss data throughput
world first scientific space experiment carried flight first artificial earth satellite aes sputnik ionospheric experiment performed izmiran direction prof alpert sunrise sunset variations aes radio signal recorded determine distribution electron density topside ionosphere maximum experiment demonstrated capabilities satellite radio beacon method important widely used studying ionosphere paper describes history results experiment well contribution alpert ionospheric research alpert one famous influential radiophysicists author many fundamental studies number classic books theory propagation electromagnetic waves interaction artificial bodies ionospheric plasma ionospheric radio scattering use satellite radio beacon methods studying ionosphere give paper extracts alpert research notes include history publication results recordings sputnik transmitter signals described method data analysis first scientific publication based sputnik data given abbreviated summary end paper outline alpert scientific biography cospar published elsevier ltd rights reserved
virtual desktop infrastructure vdi solutions seek provide satisfactory user experience client side accessing remote desktop applications even mobile devices limited capabilities paper presents new approach improving previous work authors combination virtual network computing vnc streaming protocols allowed efficient remote web access virtualized applications within cloud architecture new approach simplifies virtual machine templates virtual machine instances deployed centralizing software modules greatly simplifying management new contribution consists integrated solution specific webm video encoding modules charge application visual output processing hypertext transfer protocol http streaming server vnc server solution installed hypervisor host machines instead replicating servers modules throughout guest virtual machines run virtualized applications consequently implementations unique independent operating system virtual machines short necessary provide different implementations different operating systems reduces complexity virtual machine templates greatly simplies platform management demonstrate solution modified quick emulator qemu kernel based virtual machine kvm hypervisor source code accordingly also present qualitative quantitative analyses demonstrate new approach advantageous terms software management quality experience compared previous work well known thin clients contributing enhancement vdi systems copyright john wiley sons ltd
introduction early diagnosis monitoring disease activity prediction treatment response structural outcome remain major challenges spondyloarthritis spa biomarkers could play role addressing challenges spa lack suitable biomarkers areas covered spa clinically pathophysiologically closely related psoriasis inflammatory bowel disease ibd reviewed literature value serum biomarkers conditions aim find potential candidates assessing spa expert commentary candidates interest antimicrobial peptides including serum human beta defensin hbd lipocalin lcn class mhc molecule beta microglobulin since biomarkers relevant psoriasis ibd pathophysiological point view may play role pathogenesis spa recommend exploration value biomarker diagnosis prognosis spa
carbonic anhydrase inhibitors often determined stopped flow hydration assay method directly follows inhibition enzymatic activity however assay limitations largely unknown concentration inability determine several widely used direct binding assay isothermal titration calorimetry also determine several contrast thermal shift assay accurately determine picomolar affinities new equations estimating concentration developed determination cat inhibitor dose response curves analyzed using hill morrison equations demonstrating morrison model applicable determination tight binding inhibitor measurements interactions ten inhibitors seven isoforms showed limitations advantages three techniques inhibitor exhibited highly selective towards human isoform nearly absent healthy human highly expressed numerous cancers combination inhibition binding techniques necessary precise determination high affinity inhibitor interactions future drug design elsevier inc rights reserved
use smart grid developing intelligent applications current trend great importance one advantage lies possibility direct monitoring devices connected electrical network order prevent possible malfunctions therefore paper proposes method automatic detection malfunctioning low intelligence consumer electrical devices malfunctioning means deviation household device normal operating schedule method based comparison technique consisting correlation current power signature device ideal signature standard signature provided manufacturer first step method achieve simplified form power signature keeps original features signal segmented based data provided event detection algorithm values first derivatives resulting component approximated using regression function final step consists analysis based correlation computed regression coefficients coefficients standard signal following analysis differences classified malfunctioning analyzed device
efficacy transdermal fentanyl cancer pain chronic non cancer pain chronic lower back pain rheumatoid arthritis osteoarthritis neuropathic pain well established several formulations fentanyl transdermal systems developed improve drug delivery prevent misuse active principle addition rate controlling membrane matrix system represented important advance design functional features alghedon patch compared approved generic fentanyl transdermal systems emphasizing distinctiveness alghedon patch alghedon patch liquid component finished product therefore leakage active ingredient system occur rate controlling membrane provides controlled release active substance matrix reservoir ensuring fentanyl delivery entry microcirculation solely controlled skin permeability active substance alghedon patch contains part drug approximately skin contact adhesive innovative solution allows overcome typical drawback transdermal patches long lag time drug appears plasma first administration provides rapid analgesia first hours administration alghedon fentanyl transdermal system employs materials commonly used transdermal applications established safety profiles strength level fentanyl content thus resulting residual fentanyl remaining patch use lowest end range used commercially available fentanyl patches minimizing potential abuse misuse
alzheimer disease neurodegenerative disorder common cause dementia elderly intracellular neurofibrillary tangles nfts one pathological features recent studies suggested long noncoding rnas lncrnas play important roles competing endogenous rnas cernas mechanism recently proposed incrnas compete common mirna binding sites mrnas however roles incrnas cerna nfts limited study constructed global triple network based cerna theory nft lncrna mrna network nftlmn generated analyzing nftlmn three incrnas highly related nfts identified explore cross talk mrnas incrnas clustering module analysis performed nftlmn two nft related modules identified study provides better understanding molecular basis nfts may offer novel treatment strategies published elsevier inc
environmental forces produce undesired vibrations mechanical structures limit precision mechanical equipment cause mechanical failure piezoelectric shunt damping attractive technique controlling vibrating structures reliable economical light weight phononic crystal internal component whose elastic constant density sound velocity change periodically elastic wave passes phononic crystal special dispersion curve formed due interaction periodic arrangement materials order study electromagnetic oscillation band gap piezoelectric phononic crystal lcr shunt network torsional flexural vibration propose new phononic piezoelectric beam composed aluminum epoxy resin piezoelectric patch strained electrical energy dissipated current flows external lcr shunting circuit combining piezoelectric effect mechanical vibration smart material equivalent additional stress piezoelectric patches deduced moreover coupling energy band theory phononic crystal effect electromagnetic oscillation calculate band gap characteristics torsional flexural vibration intelligent material using transfer matrix method bloch theorem periodic boundary conditions band gap phononic beam calculated increase resistance amplitude attenuation band gap decreases however expand frequency range inherent frequency electromagnetic oscillation root sum capacitance inherent capacitance total capacitance shunting circuit therefore frequency electromagnetic oscillation decreases increases capacitance inductance amplitude attenuation band gap increases increase inductance decreases greatly rise capacitance three main differences lcr shunt networks traditional circuits found first band gaps phononic piezoelectric smart material composed bragg band gaps local resonant band gaps former one due mismatch aluminum epoxy resin makes elastic waves corresponding vibration modes certain frequencies latter one effect electromagnetic oscillation lcr shunt networks consume energy resistor second tuning resistance capacitance inductance change singularity position stress magnitude equivalent additional force curve amplitude attenuations locally resonant band gaps electromechanical coupling coefficient changed third locations widths band gaps tuned simply varying value negative capacitance shunting networks without needing modify configuration structure therefore provides new idea controlling vibration reducing noise phononic piezoelectric smart material
present storage management system ability adapt data access characteristics application uses based collection analysis runtime statistics feature especially useful storage management layer database systems applications exhibit relatively predictable access patterns adaptive reorganization performed storage management system manner optimizes access patterns system used enhance log structured storage system naturally caters write optimization addition statistics collection mechanism determine data access patterns applications storage system serve testbed variety statistics analysis clustering mechanisms higher level application specific data clustering mechanisms used override storage system low level clustering mechanisms addition analysis techniques reorganization scheme used storage systems performance results prototype show potential response time speedups percent basic log structured file system best case using combination storage reorganization prefetching
paper addresses investigation hydrodynamic behavior new type cap trays called conical cap tray concap tray computational fluid dynamics model developed predict hydrodynamics concap tray operated spray regime model considers two phase flow gas liquid vof like code framework homogeneous multiple size group model musig model shear stress transport sst turbulence model implemented detailed insights hydrodynamic behavior inside cones obtained relation velocity pressure cross section area flow inside cone also formulated computational fluid dynamic cfd results show pressure variation cones forces liquid tray highly turbulent leads deform interface break effect different riser heights also studied cfd simulations results show riser height significant role hydrodynamics tray especially uniform gas distribution tray reducing weeping rates
method modeling fluid solid interactions saturated porous media proposed main challenge combination material spatial descriptions deformation solid serves container fluid studied following motion material particles lagrangian description hand motion fluid described spatial form using eulerian approach however solid deforms implies certain difference regarding standard formulation used spatial description fluid mechanics fixed grid dissects space elementary volumes grid longer fixed elementary volumes follow deformation solid moreover solid well fluid balance equations formulated current configuration interaction forces couples taken account using zhilin approach entropy temperature incorporated system equations constitutive equations constructed elastic inelastic components force couple stress tensors interaction force couple constitutive equations elastic components found basis energy balance equation constitutive equations inelastic components proposed accordance second law thermodynamics particular emphasis placed constitutive equations interaction force couple result symmetric form hybrid approach combining lagrangian eulerian description three possible examples application theory presented example required assumptions first stated discussed complete set corresponding equations presented
peripheral blood mononuclear cells pbmcs play critical role clearing hepatitis virus hcv pbmc defects linked hcv infection however underlying mechanisms remain obscure hypothesized pbmcs hcv infected patients susceptible programmed cell death pcd therefore unable clear hcv compared spontaneous pbmc pcd cytokine interleukin secretion untreated naive hcv treated sustained responder patients hcv hcv healthy controls spontaneous pbmc pcd assessed annexin fluorescein isothiocyanate propidiumiodide staining cytokine levels measured cytometric bead array differences groups analyzed paired nonpaired tests mann whitney test rate spontaneous pcd higher pbmcs naive hcv patients hcv patients hcv controls significantly low levels detected supernatant cell cultures pbmcs naive hcv hcv patients relative hcv controls difference naive hcv hcv groups terms pbmc pcd rate cytokine levels present findings indicate hcv infection associated increased pbmc susceptibility pcd decreased production
buoyancy engine swashplate type axial piston pump developed oil extrusion drawing properties high hydraulic pressure evaluated buoyancy engine installed underwater glider achieve long term monitoring ocean environments depth designated area lower operational costs bidirectionally functioning pump control amount oil extrusion draw operations drawing oil high pressure hydraulic pump electric motor respectively act hydraulic motor electric generator generated electric power absorbed damping resistor oil drawing extrusion properties measured using large hyperbaric chamber able produce almost identical environment actual operations results confirmed stable oil extrusion operations mpa regarding oil drawing properties although measured mpa hyperbaric chamber inferred system draw oil control buoyancy precisely mpa replacing two way ball valve electromagnetic latching solenoid valve
ensuring torque smoothness essential requirement wide range high performance applications based permanent magnet synchronous machines pmsm reported work proposes novel technique compensation torque oscillations essentially caused spatial harmonics result machine design imperfectness operating uncertainties main idea proposed method modify conventional pmsm controller superposing appropriate compensating signal inner current loop proposed approach allows minimizing torque ripple simple synthesis compensating signal require hard calculation cost theoretical analysis simulation results presented show effectiveness proposed compensating method
class retrieval gene expression microarray data analysis highly challenging task high class imbalance highly dimensional feature space small number samples algorithms fail capture real complex structures data golden standard therefore one major problems area selection best suited algorithm data hand address problem proposing extended meta learning framework ranking selection algorithms clustering gene expression microarray data proposed framework introduces several improvements compared original one extended algorithm space extended meta feature space introduction cutting edge techniques meta feature selection parameter optimisation meta algorithms system evaluated large algorithm problem space algorithms datasets showed promising results prediction algorithm performance specific problems
paper presents design sampled analog wavelet processor architecture cochlear implant application using discrete haar wavelet transform basic element sampled analog wavelet processor architecture operational amplifier based switched capacitor integrator circuit architecture distributes input signal frequencies different predefined frequency band based cochlear sensitivity region different frequencies using arbitrary tree structure presented architecture beneficial terms processing time input signal area complexity avoiding quantization encoding process part data converter circuits simulation results architecture carried cmos technology
paper presents image reconstruction method monitor temperature distribution electric generator stators main objective identify insulation failures may arise hotspots structure method based temperature readings fiber optic distributed sensors dts sparse reconstruction algorithm thermal images structure formed appropriately combining atoms dictionary hotspots constructed finite element simulation multi physical model due difficulties reproducing insulation faults real stator structure experimental tests performed using prototype similar real structure results demonstrate ability proposed method reconstruct images hotspots dimensions representing resolution gain six times compared dts spatial resolution addition satisfactory results also obtained detect hotspots application proposed algorithm thermal imaging generator stators contribute identification insulation faults early stages thereby avoiding catastrophic damage structure
introduction involvement extreme sensory processing patterns impulsivity alexithymia hopelessness hypothesized contribute complex pathophysiology major depression bipolar disorder however nature relation variables thoroughly investigated aims study aimed explore association extreme sensory processing patterns impulsivity alexithymia depression hopelessness methods recruited euthymic participants mean age unipolar major depression bipolar disorder participants completed adolescent adult sensory profile aasp toronto alexithymia scale tas second version beck depression inventory bdi barratt impulsivity scale bis beck hopelessness scale bhs results lower registration sensory input showed significant correlation depression impulsivity attentional motor impulsivity alexithymia significantly frequent among participants elevated hopelessness accounted variance depression severity greater impulsivity alexithymia hopelessness elevated sensory seeking correlated enhanced motor impulsivity decreased non planning impulsivity higher sensory sensitivity sensory avoiding correlated depression impulsivity alexithymia limitations study limited relatively small sample size cross sectional nature study furthermore self report measures may potentially biased social desirability used conclusion extreme sensory processing patterns impulsivity alexithymia depression hopelessness may show characteristic pattern patients major affective disorders careful assessment sensory profiles may help developing targeted interventions improve functional adaptive strategies
consumer protection electricity pricing issues emerge consumers generate electric power installing solar photovoltaic panels known solar distributed generation nowadays centre interest public administration citizens far concerns energy supplies households new inter relations occur result technological advance despite fact output solar panel precisely predicted marginal cost generating electricity renewable energy sources nearly zero made renewable sources inclusion solar panels first choice utility firm fulfilling customer energy demand look economics electricity pricing issue consumer protection associated distributed generation developed economies example usa results might help stakeholders policy makers well energy companies obtain deeper insight problematique given united states dangerously affected climate change use solar renewable energy would great benefit controlling environmental hazards caused use non renewable energy environment government socially influential stakeholders must initiate participate public awareness campaign concerning policies concept net metering pricing solar products
school absenteeism significant social public health problem however existing prevalence rates often representative due biased assessment processes schools present study assessed school absenteeism germany using nationwide online self report survey although definition school absenteeism conservative previous studies nearly high school students reported school absenteeism within past days absent students lived less often parents average lower socioeconomic status reported emotional problems behavioral problems less prosocial behavior attending students indicator wide variety problems children adolescents school absenteeism deserves much attention future directions research implications prevention intervention programs discussed
paper construct soliton solutions generalized variable coefficient coupled hirota maxwell bloch system describe ultrashort optical pulse propagation nonlinear dispersive fiber doped two level resonant atoms certain transformations constraints one two soliton solutions obtained via hirota method symbolic computation soliton collisions graphically presented analyzed one soliton shown maintain amplitude shape propagation soliton collision elastic bright two peak solitons dark two peak solitons also observed discuss influence coefficients group velocity group velocity dispersion gvd self phase modulation distribution dopant stark shift soliton propagation collision features coefficients set constants functions respectively find group velocity self phase modulation change solitons amplitudes widths solitons become curved gvd distribution dopant chosen functions stark shift chosen certain constant two peaks bright two peak solitons dark two peak solitons parallel addition observe periodic collision two solitons
public policy efforts restrict children access electronic games violent sexual content often predicated assumptions parental concerns initial step determining whether assumptions accurate authors conduct focus groups adolescent boys parents guardians explore parents concerns compare parents children perceptions see whether consistent focus proposed legislation public policy efforts parents primary concern games interfere children schoolwork social skills exercise worry exposure violent content definitions opinions harmful vary may match proposed public policies
crystallization behavior aucu metallic glass continuous heating cooling isothermal treatment investigated ultrafast calorimetry relationship transformation time temperature scales alloy established experimentally wide temperature range glass transition temperature melting point temperature dependent viscosity expanded supercooled liquid region derived thermodynamic kinetic analysis crystallization behavior metallic glass nucleation rate growth velocity crystallization supercooled liquid analyzed applying classical nucleation theory diffusion controlled growth theory acta materialia inc published elsevier ltd rights reserved
eyes play important role expressing emotions nonverbal communication present study emotional expression classification performed based features automatically extracted eye area first face area eye area automatically extracted captured image afterwards parameters used analysis discrete wavelet transformation obtained eye area using parameters emotional expression analysis performed artificial intelligence techniques result experimental studies universal emotions consisting expressions happiness sadness surprise disgust anger fear classified success rate using artificial neural networks
objective assemble synthesize best evidence oil epidemiology diagnosis prognosis treatment prevention musculoskeletal injuries pain dancers data sources medline cinahl psycinfo embase electronic databases searched sin key words dance dancer dancing athletic injuries occupational injuries sprains strains musculoskeletal diseases addition reference lists relevant studies examined specialized journals hand searched websites major dance associations scanned relevant information study selection citations screened relevance using priori criteria relevant studies critically reviewed scientific merit best evidence synthesis method abstracts screened articles reviewed accepted scientifically admissible representing unique studies data extraction data accepted studies abstracted evidence tables relating prevalence associated factors incidence risk factors diagnosis treatment economic costs prevention musculoskeletal injuries pain dancers data synthesis scientifically admissible studies consisted cohort studies cross sectional studies validation study diagnostic assessment tool high prevalence incidence lower extremity back injuries soft tissue overuse injuries predominating example lifetime prevalence estimates injury professional ballet dancers ranged point prevalence minor injury diverse group university professional ballet modern dancers several potential risk factors injury suggested literature conclusive evidence lacking preliminary evidence comprehensive injury prevention management strategies may help decrease incidence future injury conclusions dance medicine literature young heterogeneous limiting ability draw consistent conclusions nonetheless best available evidence suggests musculoskeletal injury important health issue dancers skill levels better quality research needed specialized area future research would benefit clear relevant research questions addressed appropriate study designs use conceptually valid clinically meaningful case definitions injury pain better reporting studies line current scientific standards
sensitive gas chromatography mass spectrometry method established simultaneous determination thirteen nitrosamines nas skin care cosmetics cosmetics samples firstly dispersed water subsequently extracted purified using salting acetonitrile homogeneous extraction method finally extracting solution concentrated slow nitrogen gas blowing samples separated innowax capillary chromatographic column detected selected ion monitoring sim mode gas chromatography mass spectrometry quantified isotope internal standard method method validated linearity range accuracy precision sensitivity optimized condition calibration curves linear selected concentration ranges thirteen analytes calculated coefficients determination greater limits detection lods limits quantitation loqs method respectively recoveries calculated three levels concentration spiked two kinds cosmetics skin care cream water values found relative standard deviation rsd values intra day precision inter day precision method successfully applied analyze twenty two cosmetics samples nitrosodimethylamine ndma detected one sample concentration elsevier rights reserved
present investigation sensing electrode electrochemical gas sensor plate type design engineered overcome various observed failures dying short time due diffusion material discontinues electrical contact results inadequate catalytic action improve sensing electrode performance gradient sputtered coat applied increasing thickness towards centre pellet another design loaded varying concentration electrolyte material coat applied electrolyte overcome diffusion performance different sensors varied configuration catalyst compared parameters namely stability response time gradient sputtered electrode gave fast electrode kinetics whereas sensor stability found better loaded material insight effect loading binary electrolyte lico caco obtained complex impedance spectroscopy
paper presents way optimize program sliding mode control implemented microcontroller incorporates analog comparator internal peripheral main idea save microcontroller processing capability avoiding use analog digital converter saved capability used tasks depend application case saved processing capability used generate necessary signals control integrated ballast ballast selected example non resonant ballast integrates single stage full bridge inverter buck converter ballast responsible feeding hid lamp alternating current also responsible stabilizing current therefore control signals necessary achieve tasks complicated signals used control ordinary full bridge inverter proposed algorithm sliding mode control good alternative applications power converters used experimental results shown
cutaneous squamous cell carcinoma cscc malignancy epidermal keratinocytes responsible similar annual skin cancer associated mortalities accumulating evidence demonstrates dysregulation micro rnas serves significant role tumorigenesis progression human cscc microrna mir upregulated cscc involved cscc development however underlying mechanism remains unclear present study demonstrated mir upregulated cscc cell line mir expression contributes cell proliferation invasion cscc addition bioinformatics combined dual luciferase reporter analysis applied determine tumor suppressor rhotbt direct target mir addition mir mimics reduced rhobtb expression cells results mtt transwell assays demonstrated knockdown rhobtb short interfering rna induced cell proliferation invasion cells results indicated suppression rhobtb may involved cscc tumorigenesis directly affected mir conclusion present study provides evidence mir acts oncogene direct repression rhotbt expression cscc cancer suggesting potential application mir prognosis prediction therapeutic application cscc
gas condensate reservoirs high water cut near wellbore retrograde condensate pollution main problems encountered engineers thus good understanding influence water vapor complex phenomenon near wellbore region phase behavior gas condensate critical forecast performance reservoir fluids guide exploitation gas condensate reservoirs present work constant composition expansion cce constant volume depletion cvd measurements performed determine phase behavior gas condensate samples without water vapor experimental results demonstrate water vaptir increases dew point pressure also influences gas related properties furthermore several equations applied predict solubilities gas related properties predictions compared obvious cubic plus association cpa equation state eos performs well properties test fitting interaction parameter good agreement experimental data predictions observed elsevier rights reserved
purpose study extend investigation criminal thinking persons mental illness beyond prison community settings jail setting participants consisted individuals incarcerated county jail diagnosed severe mental illness including schizophrenia spectrum major mood disorders results indicated people mental illness sample jail inmates presented thinking styles support criminal lifestyle criminal thinking styles follow pattern similar sample prison inmates serious mental illness findings support need therapeutic programs justice involved persons serious mental illness develop multipronged treatment approach integrates interventions individuals criminal thinking antisocial attitudes treatment mental illness substance abuse issues
paper discuss asymptotic behavior doubly non linear problem describing vibrations coupled suspension bridge single span road bed modeled extensible viscoelastic beam simply supported ends main cable modeled viscoelastic string connected road bed distributed system one sided elastic springs constant axial force applied one end deck time independent vertical loads allowed act road bed suspension cable general model obtain original results including existence regular global attractor element
specific leaf area sla defined leaf area per unit dry leaf mass important component assessing functional diversity plays key role ecosystem modeling linking plant carbon water cycles well quantifying plant physiological processes however studies sla variation across relevant spatial temporal scales lacking remote sensing fast efficient approach quantify vegetation parameters insufficient studies estimating sla remotely sensed data article aims finding efficient hyperspectral indices fast accurate estimation sla leaf canopy spectral measurements validation results data measured leaf canopy scale well experimental datasets simulated using prospect leaf level inform canopy level revealed sla predicted accurately several indices simple ratio normalized index types bands sensitive sla selected using indices spectral region leaf level ratio index bands performed strongly rmse cross validation multiband indices central wavelengths also among top performing indices measured simulated leaf level data canopy level soil adjusted ratio vegetation index band setting showed hyperspectral data hyspex airborne imagery accurately estimated sla rmse generally canopy level potential indices accurate retrieval sla hyspex imagery two band indices soil line information discrepancy observed performance band combinations vegetation indices leaf canopy scales explained external factors canopy structure soil background illumination sensor configuration affect signal moving leaf canopy level findings suggest availability suitability wide range existing vegetation indices assessing sla accurately rapidly remotely sensed data elsevier rights reserved
background department veterans affairs largest provider hepatitis treatment although antiviral regimens becoming simpler hepatitis antivirals typically prescribed primary care providers veterans affairs extension community health outcomes echo program launched promote primary care based hepatitis treatment using videoconferencing based specialist support aimed assess whether primary care provider participation echo associated hepatitis treatment sustained virologic response methods identified primary care providers sites responsible patients chronic hepatitis infection total patients primary care provider participating echo patients unexposed primary care provider exposure modeled patient level time varying covariate patients became exposed primary care provider participation echo session multivariable cox proportional hazards frailty modeling assessed association echo exposure hepatitis treatment among treated patients modified poisson regression assessed relationship exposure sustained virologic response results adjustment exposed patients received significantly higher rates antiviral treatment compared unexposed patients adjusted hazard ratio confidence interval rate primary care provider initiated antiviral medication among treated patients reviewed echo teleconferences compared among unexposed patients difference adjusted rates sustained virologic response observed patients exposed primary care providers similar crude rates primary care providers versus specialists conclusions national implementation echo positively associated hepatitis treatment initiation primary care providers without differences sustained virologic response published elsevier inc
work progress describes study intended determine whether self regulated learning strategies influence academic performance students department electrical electronics engineering universidad nacional colombia research conducted students two terms surveyed use learning strategies using ceam psychometric tool later analyzed whether significant correlation exists scores obtained questionnaire grades reached two courses engineering curriculum found strategies related academic achievement courses whereas ones influence one results professors preparing methods activities oriented foster use strategies order improve student academic performance electrical circuits analog electronics courses
introduction examine relationship severe vitamin deficiency asthma control pulmonary function turkish adults asthma methods one hundred six asthmatic patients underwent pulmonary function tests skin prick test peripheral blood eosinophil counts ige body mass index vitamin levels determined patients divided subgroups according vitamin levels vitamin level asthma control tests performed results mean age subgroup vitamin level sixty six percent patients severe vitamin deficiency vitamin level significant trend towards lower absolute fev values patients lower vitamin levels asthma control test scores significantly low severe deficiency group group greater number patients uncontrolled asthma asthma control test scores severe vitamin deficiency group patients severe vitamin deficiency higher usage inhaled corticosteroids group without severe vitamin deficiency significant trend towards lower absolute fev values patients lower vitamin levels vitamin levels inversely related body mass index conclusion incidence severe vitamin deficiency high adult turkish asthmatics addition lower vitamin levels associated poor asthma control decreased pulmonary function separ published elsevier espana rights reserved
pyoderma gangrenosum represents rare skin disorder several clinical variants still fully understood ethiopathogenesis often associated inflammatory neoplastic disease nowadays considered inflammatory neutrophilic disease common underlying morbidity modern treatment options oriented towards key mechanisms underlying pathogenesis disease namely inflammatory mediators seem effective treatment currently available although promising results invariable treatments sometimes surrounded controversy recent studies reported cases refractory therapy biological agents possible refractoriness use biological agents monotherapy stems fact single agent able affect entire inflammatory cascade simultaneously influence levels based pathogenesis inflammation suggest ideal targeted therapy able induce following changes reduction secretion interleukin inflammasome subsequent blocking biological effect therapy receptor antagonists blocking activation secreted procytokines active form therapy caspase inhibitors blocking effect already released active cytokines therapy tumour necrosis factor alpha tnf alpha inhibitors blocking effector action cytokines target intracellular molecules therapy kinase inhibitors specific therapy aim attack one link inflammatory cascade order achieve maximum therapeutic effectiveness surely could achieved combined therapy different groups biological agents example combined therapy receptor antagonist tnf alpha inhibitor currently data literature exist support statement safety data relating approaches focus review novel etiopathogenetic concepts future therapeutic approaches based blocking different levels inflammatory cascade seems promising weapon target oriented treatment options
number studies shown prosocial behavior associated enhanced well prior experimental studies involved actual potential face face contact beneficiary establish prosocial behavior increased sense social relatedness recipient improves well participants invited play simple computer game half made aware chance anonymous prosocial impact gameplay compared control condition group experienced positive affect meaningfulness marginally vitality going beyond self reported outcomes also demonstrated better post game performance subsequent stroop task providing behavioral evidence positive effects prosocial behavior also supported hypothesis positive effects prosocial behavior well mediated subjectively assessed autonomy competence need satisfactions
background autoantibodies apolipoprotein anti apoa igg emerged independent biomarker cardiovascular disease mortality however association cause mortality community well genetic determinants studied objective determine whether anti apoa igg predict cause mortality general population associated single nucleotide polymorphisms snps genome wide association study gwas methods clinical biological genetic data obtained population based prospective colaus study including participants mean age years men followed median duration years primary study outcome cause mortality results multivariate adjustment anti apoa igg positivity independently predicted cause mortality hazard ratio confidence interval dose effect relationship also observed logarithmically transformed anti apoa igg associated increase mortality risk gwas yielded nine snps belonging receptor like fcrl gene significantly associated anti apoa igg levels lead snp explaining anti apoa igg level variation conclusion anti apoa igg levels independently predict cause mortality general population linked fcrl susceptibility gene numerous autoimmune diseases findings indicate preclinical autoimmunity anti apoa igg may represent novel mortality risk factor
aimsthe aim develop new laparoscopic technique placement pudendal lead methodsdevelopment direct feasible reliable minimal invasive laparoscopic approach pudendal nerve thirty one embalmed human specimens dissected relevant anatomic structures pelvis step step documentation analysis laparoscopic approach order locate directly course around medial part sacrospinous ligament test approach feasibility landmarks intraoperative navigation towards well possible position lead selected demonstrated resultsthe visible medial umbilical fold intrapelvine part internal pudendal artery coccygeus muscle sacrospinous ligament main landmarks traverses medial part sacrospinous ligament dorsally medially internal pudendal artery medial part sacrospinous ligament exposed order display nerve lead placed ventrally nerve around depending lead type shape conclusionsa precise reliable identification means laparoscopy feasible easy four step approach identification medial umbilical fold identification internal iliac artery identification internal pudendal artery incision coccygeus muscle white line arcuated line exposition medial part sacrospinous ligament display
background food allergy affects around european population prevalence worldwide increasing last decades studies focused investigating food allergy epidemiology europe lacking objective cibus project created register main culprit foods clinical manifestations food allergic patients catalonia methods specific online database designed allergists eight different catalan hospitals registered new diagnoses food allergy results food allergic patients included egg milk main elicitors early ages fruits nuts frequent patients years old fish frequent children seafood anisakis allergy frequent year old group overall peach prevalent food eliciting allergic reaction food allergy diagnosis reached using compatible clinical history positive skin prick test involved food cases globally urticaria frequently reported manifestation population followed oral allergy syndrome anaphylaxis conclusions cibus project gives full overview profile food allergic patients catalonia reinforces predominance plant food allergies mediterranean area seicap published elsevier espana rights reserved
chlamydophila pneumoniae gram negative bacterium belongs family chlamydiaceae known cause community acquired pneumonia bronchitis need genomic analyses pneumoniae chronic infections result reactive airway disease lung cancer asthma recent advancement sequencing techniques led generation large genomic data order utilize data sequence based function predictions used annotating uncharacterized genes genome pneumoniae encodes proteins include group functionally uncharacterized proteins known hypothetical proteins hps functions hps predicted utilizing integrated approach combines varieties bioinformatics tools functions proteins successfully predicted categorized different classes enzymes transport proteins binding proteins virulence factors among functionally annotated hps able identify virulent hps furthermore highest virulence score subjected molecular dynamics simulations better understand dynamical behavior explicit water conditions analyses could utilized depth understanding virulence mechanism functional knowledge proteins could useful drug design discovery process infections caused pneumoniae
adolf martens pioneer materials engineering studies berlin joined railway company responsible technical equipment interest basic mechanisms mechanical strength fracture metallic materials led development basic concepts metallography papers published laid fundament technique martens changed royal industrial academy berlin designated director materials testing laboratory technical university berlin guidance institution acquired excellent reputation relevant areas german industry forming nucleus bundesanstalt fur materialforschung und prufung bam federal institute materials research testing martens developed equipment many different areas mechanical testing metallic materials paper characterization wear behavior materials viscosity lubricants overwhelming contribution materials engineering recognized early floris osmond denominated martensite metallographical constituent resulting quenching steels iso designated value obtained instrumented indentation method martens hardness elsevier ltd rights reserved
assay technologies capable detecting biomarker concentrations unprocessed whole blood samples fundamental applications medical diagnostics sers nano tags integrated fiber optic biosensor fob realized first time situ immunoassay whole blood reliability sensitivity method rely large extent quality properties sers nano tags constructed silica coated sers nano tags labels used rapid specific situ fob immune sensor detect alpha fetoprotein afp unprocessed blood samples preliminary results vivo situ dynamic observation afp whole blood wistar rat highlight power new method
recommended daily intake iodide adolescents adults pregnancy lactation thyroid gland effective collector iodine active iodine uptake along basolateral membrane thyroid cell followed transport apical edge cell follicle lumen tsh acts camp stimulates nis gene expression protein synthesis major proportion iodine thyroid gland bound thyroglobulin non organic intrathyroidal iodine usually low significantly greater compared plasma large doses iodine reduce uptake organification wolff chaikoff effect cause partial inhibition proteolysis thyroid gland several protective mechanisms resulting maintenance normal thyroid function despite wide fluctuations daily iodine intake ingestion several commonly used drugs food conservatives results acute chronic excessive iodine intake failure escape iodine induced organification inhibition cause hypothyroidism temporary subsides iodine exposure ceases iodine excess may also establish status excessive thyroid hormone synthesis release thus inducing autonomic thyroid function iodopenic areas contribute development iodine induced hyperthyroidism iodine abundant areas anti arrhythmic amiodarone benzofuranic product high iodine content associated either hypo hyperthyroidism development presence defective auto protective mechanisms excessive iodine ingestion divert normal thyroid function
precise engineering phonon phonon electron phonon interactions materials design essential depth understanding thermal electrical optical phenomena well new technology breakthrough governed fundamental physical laws due characteristic length scale interactions dramatically modified nanoscale spatial confinement thus opening opportunities finely maneuver underlying coupling processes interplay confined size fundamental length scale interface combined ultrafast optical spectroscopy series well designed nanoscale core shell structures possessing precisely tunable interface demonstrate first time unambiguous experimental evidence coherent interfacial phonon coupling core shell constituents interfacially coupled phonons impulsively excited interaction critical coupling constant shown monotonically controlled tuning configuration constituent core shell nanostructure precise tunability elemental physics processes nanoscale materials engineering offer fundamental insights different materials properties also facilitate design devices possessing desirable functionality property rationally tailored nanostructures building blocks
mentalization based treatment mbt new development field psychodynamic therapy particularly aims patients severe difficulties affect regulation initially mbt developed treatment patients borderline personality disorder moment scope mbt broadened mental disorders psychosis eating disorders antisocial personality disorder well low personality functioning adolescence core model mbt regarding therapeutic stance technique aims restore mentalization especially context attachment relationships contrast psychodynamic therapies mbt remains focus current affects relationships including therapeutic relationship initial evidence mbt shows effectiveness particular patient groups addressed
people differ implicit theories malleability characteristics intelligence personality relatively chronic theories experimentally altered affected parent teacher feedback little known whether people might selectively shift implicit beliefs response salient situational goals predicted motivated reach desired conclusion people might subtly shift implicit theories change stability garner supporting evidence desired position motivated context particular lay theory would help people reach preferred directional conclusion could elicit shifts theory endorsement examine variety motivated situational contexts across studies finding people theories change shifted line goals protect self liked others cast aspersions disliked others studies demonstrate people regulate implicit theories manage self view strongly endorsing incremental theory threatening performance feedback memories failure studies revealed people regulate implicit theories hold favored reviled political candidates endorsing incremental theory forgive preferred candidates past gaffes leaning toward entity theory ensure past failings stick opponents finally study people threatened previously convicted child sex offender parents reading offender moving neighborhood gravitated entity view others change although chronic implicit theories undoubtedly meaningful research reveals previously unexplored source fluidity highlighting active role people play managing implicit theories response goals
article introduces theory constraints supply chain manufacturing engineering field establishes fmcg supply chain fuzzy comprehensive evaluation model use practical research support research result fmcg profit model comparing toc model non toc model fmcg supply chain performance demonstrate advantage introducing toc model fmcg supply chain performance management field
introduction since drinking water vehicle transmission pathogens detection enteric viruses water samples essential establish appropriate measures control prevent associated diseases objective analyze results obtained enteric viruses water samples human consumption received colombian instituto nacional salud establish association data water quality colombian municipalities materials methods conducted descriptive retrospective analysis results obtained detection rotavirus enterovirus hepatitis virus adenovirus water samples received complementary studies enteric hepatitis acute diarrheal disease foodborne diseases data correlated results water quality surveillance determined national human consumption water quality index irca results samples processed colombian municipalities positive viruses hepatitis virus enterovirus rotavirus adenovirus viruses detected non treated water samples treated water samples irca index showed correlation presence viruses conclusions presence viruses water represents public health risk therefore prevention virus transmission water requires appropriate policies reinforce water supply systems improve epidemiological surveillance
study aims assessing relative contribution employment specialist competencies working supported employment programs client variables determining likelihood obtaining competitive employment total persons severe mental illness employment specialists working programs across three canadian provinces included study overall sample obtained competitive work client variables employment specialist competencies controlling quality programs implementation predicted job acquisition multilevel analyses indicated younger client age shorter duration unemployment client use job search strategies well working alliance perceived employment specialist strongest predictors competitive employment people severe mental illness variance explained people severe mental illness seeking employment active job search behaviors relational abilities employment specialist competencies central contributors acquisition competitive employment
shodan acknowledged one popular search engines available today designed crawl internet index discovered services paper expands features exposed shodan advanced vulnerability assessment capabilities embedded novel tool called shodan based vulnerability assessment tool shovat shovat takes output traditional shodan queries performs depth analysis service specific data service banners embodies specially crafted algorithms rely novel memory data structures automatically reconstruct common platform enumeration names proficiently extract vulnerabilities national vulnerability database compared state art shovat brings several novel significant contributions encompasses automated vulnerability identification techniques return highly accurate results customized even purposefully modified service banners supports historical service vulnerability analysis without need deploy additional monitoring infrastructures experiments performed services different institutions across different sectors revealed high accuracy results total known vulnerabilities copyright john wiley sons ltd
recent years reduction energy consumption buildings increasingly gained interest among researchers mainly due practical reasons economic advantages long term environmental sustainability many solutions proposed literature address important issue complementary perspectives often hard capture comprehensive manner survey article aims providing structured unifying treatment existing literature intelligent energy management systems buildings distinct focus available architectures methodology supporting vision transcending well established smart home vision favor novel ambient intelligence paradigm exposition cover main architectural components systems beginning basic sensory infrastructure moving data processing engine energy saving strategies may enacted user interaction interface subsystem finally actuation infrastructure necessary transfer planned modifications environment component analyze different solutions provide qualitative comparisons also highlighting impact single design choice rest system
episodic memory working memory emotional memory attention subject dopaminergic modulation however potential role dopamine generation false memories unknown study defined role dopamine receptor true false recognition memories twenty four young healthy volunteers ingested single dose placebo oral sulpiride dopamine receptor antagonist starting recognition memory task randomized double blind placebo controlled trial sulpiride group presented false recognitions visual verbal processing placebo group although groups indices true memory findings demonstrate dopamine receptors blockade healthy volunteers specifically increase rate false recognitions findings fit well two process view causes false memories activation monitoring failures model
forced induction technology turbocharging supercharging enhance performance internal combustion engine compressing inlet air charge allowing full engine power produced efficiently fuel economy greenhouse gas emission standards projected much stringent globally use forced induction engine passenger cars light duty trucks become new inevitable trend automotive industry however conventional forced induction system suffers slow transient response especially engine speed low phenomenon typically known turbo lag electrification forced induction system called electric forced induction system efis emerged feasible solution also possesses numerous benefits depending topologies paper provides comprehensive study efis investigating system level topologies performance various types high speed machines power electronics control techniques advantages disadvantages existing electric forced induction system summarized new challenges opportunities also introduced
fattening performances nitrogen excretion health status growing rabbits studied response linear reduction digestible fibre dgf water insoluble pectins hemicelluloses crude protein ratio dfp four diets crude protein level reduced diets dfp dfp dgf level increased without changes poorly digestible fibre levels adf total rabbits per diet used multi site study weaning according sites age reduction dfp ratio led linear decrease weight gain dfp dfp associated reduced feed intake dfp dfp however whole fattening period growth intake differ significantly among diets whole fattening period old mean faecal nitrogen output per day per rabbit remained similar four diets urinary output reduced dfpi dfp accordingly total output per rabbit animals fed dfp dfp diets respectively nitrogen output per live weight rabbit produced dfp dfp respectively time increase dfp ratio reduced mortality diarrhoea two highest dfp ratios compared two lowest ratios led reduction health risk index weaning slaughtering dfpi dfp respectively significant reduction mortality rabbit epizootic enteropathy sites also observed dfp ratio increased reduction protein level favour higher digestible fibre level therefore useful feeding strategy improves resistance growing rabbit enteropathy without major impairment performances reduced nitrogen output elsevier rights reserved
due potential applications chaotic system recent years research new type chaotic system chaotic circuit hot spot however obvious differences real characteristics simulation results devices operational amplifier paper simplified method circuit improvement proposed achieves results multisim software simulation actual circuit implementation meanwhile impulsive synchronization method applied complete synchronization control chaotic system compared original circuit proposed method circuit improvement makes minor changes simulation circuit easy implemented applied chaotic systems
examine evidence concerning people believe memory focus beliefs regarding permanence memory whether memory repressed accurately recovered consider beliefs memory among undergraduate general population mental health professionals judges jurors law enforcement officers provide broad canvass extends forensic arena well psychiatry psychology allied disciplines discuss implications beliefs education general public mental health professionals regarding science pseudoscience memory use suggestive procedures psychotherapy
background hiv aids serious global health problem adverse impact human health socioeconomic status different countries objectives aim present study estimate prevalence hiv infection mashhad city methods cross sectional study performed since may september mashhad iran total individuals ranged years age selected randomly different geographical regions city proportionate sex age distribution population according census enzyme linked immunosorbent assay elisa used screen anti hiv antibodies positive samples confirmed bywestern blot assay anti hiv positive cases antibodies human tlymphotropic virus type htlv hepatitis virus hcv well surface antigen hepatitis virus hbv evaluated elisa kits results atotal serumsamples analyzed anti hiv antibodies total number participants males females mean age years respectively anti hiv seropositivity detected cases percent samples confirmed technique thus overall prevalence hiv infection case infection hbv hcv htlv observed individuals showed seroactivity hiv antibodies conclusions first population based survey showed evidence hiv infection general population mashhad seems implemented health policies strategies contributed low prevalence shall continued
prevalence obstructive sleep apnea unknown pregnancy syndrome likely underdiagnosed rising frequency along obesity epidemic obstructive sleep apnea associated adverse outcomes including hypertensive disorders pregnancy gestational diabetes preterm cesarean delivery obese pregnant women screened referred sleep medicine specialist evaluation continuous positive airway pressure treatment choice demonstrated safety compliance pregnancy early anesthesia consultation allows preparation implementation peripartum plan includes early labor analgesia avoidance respiratory depressants closer monitoring oxygenation
objectivethis study investigated impulsivity related personality traits using revised neo personality inventory neo women diagnosed occurring bulmia nervosa borderline personality disorder bpd borderline personality disorder bpd major depressive disorder mdd methodthe sample included adult female admissions psychiatric day hospital treatment program neo facets impulsiveness excitement seeking self discipline deliberation provided proxy assessment impulsivity related traits tapping negative urgency sensation seeking lack perseverance lack premeditation planning resultsafter adjusting age bpd displayed significantly higher levels negative urgency lack premeditation bpd without occurring women bpd also significantly higher levels impulsivity traits mdd across domains except lack perseverance discussionimpulsivity related traits negative urgency lack premeditation significantly differentiated women versus without occurring among women borderline personality disorder lower levels impulsivity related traits women mdd indicated effects simply attributable form psychopathology impulsivity traits negative urgency demonstrated strongest effect providing evidence important relationship negative urgency expression bulimic symptomology wiley periodicals inc int eat disord
mitochondrial dysfunction implicated pathological mechanism alzheimer disease amyloid beta protein beta plays central role pathogenesis reported accumulate within mitochondria however question remains whether beta generated locally amyloid precursor protein app within mitochondria investigated issue analyzing expression patterns app app processing secretases app metabolites mitochondria separated human neuroblastoma syy cells expressing swedish mutant apr app bace pen protein levels significantly lower crude mitochondria microsome fractions adam gamma secretase complex components presenilin nicastrin aph comparable fractions crude mitochondrial fraction containing substantial levels cathepsin lysosomal marker separated via iodixanol gradient centrifugation obtain mitochondria lysosome enriched fractions mature app bace gamma secretase complex components particular presenilin pen scarcely present mitochondria enriched fraction compared lysosome enriched fraction moreover expression beta terminal fragment beta ctf app markedly low mitochondria enriched fraction additionally immunocytochemical analysis showed little localization presenilin tom marker protein mitochondria view particularly low expression levels bace gamma secretase complex proteins beta ctf mitochondria propose unlikely beta generation app occurs locally within organelle elsevier inc rights reserved
many types dependencies software requirements contributions dependencies make help break hurt business dependencies modeled framework however current approaches prioritizing requirements seldom take dependencies consideration difficult stakeholders prioritize requirements considering preferences well dependencies requirements make requirement prioritization practical method called drank proposed drank following advantages prioritization evaluation attributes tree constructed make ranking criteria selection easier operable rankboost employed calculate subjective requirements prioritization according stakeholder preferences reduces difficulty evaluating prioritization algorithm based weighted pagerank proposed analyze dependencies requirements allowing objective dependencies automatically transformed partial order relations integrated requirements prioritization method developed amend stakeholders subjective preferences objective requirements dependencies make process prioritization reasonable applicable controlled experiment performed validate effectiveness drank based comparisons case based ranking analytical hierarchy process evolve results demonstrate drank less time consuming effective alternative approaches simulation experiment demonstrates taking requirement dependencies consideration improve accuracy final prioritization sequence elsevier inc rights reserved
organizations looking ways sustain incremental improvements end developed computer aided employee suggestion management system caesms called stars need make problem visible support employees efforts reduce waste increase employee satisfaction human interaction technology context work challenging introduction process called stars designed set stars smoothly support transition proposed solution tested three working conditions assess relevance limitations test lasted weeks indicators tests compared reference study based non technological experimentation based similar problem solving methodology restrepo int health care qual assur doi ijhcqa introduction stars technology provided relevant qualitative quantitative results cycle time closing actions reduced compared earlier study number actions progress time also reduced earlier study leadership routine substantially increases chances introducing caesms long term basis
interplay geometric frustration bond disorder studied ising kagome lattice within cluster approach model considers antiferromagnetic short range couplings long range intercluster disordered interactions replica formalism used obtain effective single cluster model thermodynamics analyzed exact diagonalization found presence introduce cluster freezing low levels disorder system exhibits entropy plateau followed large entropy drop close freezing temperature scenario spin liquid behavior prevents conventional long range order infinitesimal disorder picks uncompensated cluster states multi degenerate regime potentializing intercluster disordered coupling bringing cluster spin glass state summarize results suggest state combined low levels disorder activate small clusters providing hypersensitivity freezing process geometrically frustrated materials playing key role glassy stabilization propose physical mechanism could present several geometrically frustrated materials particular discuss results connection recent experimental investigations ising kagome compound comg
purpose model digitally controlled three phase pulse width modulation pwm boost rectifiers sampled data model different continuous time domain models presented previous studies controller tuned according model continuous time domain discretized approximation methods may exhibit unpredictable performances even result unstable systems extreme situations consequently small signal discrete time model digitally controlled three phase pwm boost rectifier required purpose paper provide simple accurate small signal discrete time model digital controlled three phase pwm boost rectifier explains effect sampling period modulator time delays system dynamic improves control performance design methodology approach based laplace domain analysis waveforms count modulator small signal model digital pulse width modulation dpwm laplace domain presented combination state space average discrete time modeling technique simplified large signal discrete time model developed rotation transformation feed forward decoupling large signal model decoupled single input single output system rotation transformation integrated small signal model laplace domain constructed included time delay modulation effect implementing modified transform small signal discrete time model derived integrated small signal model findings digital control system besides circuit parameters location pole open loop transfer function also related system sampling time affecting system stability time delay determines location zero open loop transfer function affecting system dynamic addition circuit parameters discussed previous literature right half plane rhp zero also determined sampling period time delay furthermore corner frequency rhp zero mainly determined sampling period originality value model developed paper accounting effect sampling period modulator time delays system dynamic give sufficient insight behavior digitally controlled three phase pwm rectifier also explain effect sampling period control delay time system dynamic accurately predict system stability boundary determine oscillation frequency current loop critical stable experimental results verify model simple accurate control oriented small signal discrete time model digitally controlled three phase pwm boost rectifier
background subjective memory impairment smi common among older adults increasing evidence suggests smi risk factor future cognitive decline well mild cognitive impairment dementia medial temporal lobe structures including hippocampus entorhinal cortex affected early stages alzheimer disease current study examined gray matter volume microstructural changes hippocampal entorhinal regions individuals smi compared elderly control participants without memory complaints methods total participants mean age years took part study including participants smi elderly controls without memory complaints compared volume diffusion tensor imaging dti measures hippocampal entorhinal regions smi control groups results individuals smi lower entorhinal cortical volumes control participants differences hippocampal volume found groups addition smi patients exhibited dti changes lower fractional anisotropy higher mean diffusivity smi hippocampal body entorhinal white matter compared controls combining entorhinal cortical volume hippocampal body improved accuracy classification smi control groups conclusions findings suggest entorhinal region exhibits macrostructural well microstructural changes individuals smi whereas hippocampus exhibits microstructural alterations
low levels employee trust top leaders pose challenges organizations respect retention performance profits research examines trust top leaders fostered relationships individuals direct leaders propose trickle model whereby trust direct leaders exerts upward influence trust top leaders drawing group value model predict direct leaders procedural justice serves key mechanism facilitating trickle process process particularly strong employees high vertical collectivism trickled trust top leaders exert stronger impact employees overall performance organization trust direct leaders multiphase multisource data individuals support hypotheses findings advance understanding trust leadership highlighting trust leaders different levels form independently trust leaders trickles across hierarchical levels
properties lithium ion battery electrodes relate complex microstructure develops solvent removal use cryogenic scanning electron microscopy combination broad ion beam slope cutting cryo bib sem situ imaging film formation battery electrodes drying anode films quenched cryo preservation slushy nitrogen systematically increasing drying times followed sem imaging cryogenic conditions energy dispersive ray spectroscopy eds image processing segmented cross sections used analyze development component gradients time find electrode films shrink homogeneously top consolidation process previously hypothesized binder gradients evolve liquid phase initiate solvent diffusion bulk surface thereby dragging binder towards surface capillary transport identified fundamental process directly impacts drying kinetics binder distribution elsevier rights reserved
grandparenting proposed ultimate evolutionary mechanism contributed increase human life expectancy see grandmother hypothesis neural hormonal system originally rooted parenting thus grandparenting activated process caregiving suggested potential proximate mechanism promotes engagement prosocial behavior towards kin non kin alike evidence theory suggest activating caregiving system positively impacts health may reduce mortality helper although studies found grandparental care beneficial effects grandparents health outcomes studies focused detrimental health consequences providing custodial care grandchildren little known non custodial grandparental forms care giving relate mortality hazards care provider using evolutionary framework examined whether caregiving within beyond family related mortality older adults survival analyses based data berlin aging study revealed mortality hazards grandparents provided non custodial childcare lower grandparents provide childcare non grandparents associations held controlling physical health age socioeconomic status various characteristics children grandchildren furthermore effect caregiving extended non grandparents childless older adults helped beyond families potential ultimate proximate mechanisms underlying effects discussed elsevier inc rights reserved
performance modeling mapreduce applications large scale data important issue study optimization evaluation prediction resource scheduling jobs big data cloud computing platforms paper study hadoop distributed computing framework current trend big data solutions use locally weighted linear regression lwlr algorithm linear regression algorithm establish three kinds computing models based different characteristics estimate execution time applications large scale data run hadoop framework time make comparison improvement three models building different types experimental environments running different types jobs draw conclusion three models good results predicting execution time evaluating performance large scale data applications small scale data
lower thyroid functional status within euthyroid range may confer increased atherosclerosis susceptibility evidenced increased intima media thickness coronary artery calcification associations lower thyroid functional status pro atherogenic inflammatory biomarkers may also extend euthyroid range established relationships plasma tumor necrosis factor alpha tnf alpha thyroid stimulating hormone tsh free thyroxine free euthyroid subjects without type diabetes mellitus tdm fasting tsh free tnf alpha measured nondiabetic subjects tdm subjects type diabetes mellitus tdm insulin using subjects excluded tsh free levels within institutional reference ranges tsh similar free slightly higher tdm plasma tnf alpha increased tdm nondiabetic subjects tnf alpha correlated inversely free whereas relationship absent tdm subjects multivariable linear regression analysis showed nondiabetic subjects tnf alpha remained inversely associated free adjustment age sex beta additionally thyroid autoantibodies beta contrasting lack relationship tdm subjects interaction tdm subjects tnf alpha also unrelated free taking account possible confounders well exclusion subjects using metformin antihypertensive medication conclusion higher levels tnf alpha relate lower free low normal thyroid function could influence pro inflammatory pathways relationship appears disturbed tdm
sensorimotor training wide variety available devices represents important component rehabilitation prevention different sports injuries chronic diseases purpose study evaluate effects sensorimotor training newly developed device consists instable platform moving air cushion providing dynamic balance training tilting unanticipated stochastic translations postural control seventy two healthy young subjects included prospective randomized controlled observer blinded study balance objectively assessed posturography functional reach test frt additionally evaluated subjective rating balance randomization sensorimotor training group performed training program new device week study period time improvement objective subjective measurements result training became evident significant difference challenging posturographic parameters sensory organization test training group control group head shake sensory organization test training group control group well significant difference frt training group control group found subjective assessment revealed significant improvement participants rating balance alteration balance subjects showed high satisfaction new training device findings suggest newly developed device could promising option sensorimotor training improve postural control elsevier rights reserved
sporadic alzheimer disease sad slowly progressive neurological disorder common form dementia cholinergic system dysfunction amyloid beta formation two main underlying pathological mechanisms disease development recent studies insulin receptor desensitization disturbances downstream effects insulin receptor signaling observed brains alzheimer patients currently intracereberoventricular icv injection streptozotocin stz found induce behavioral neurochemical structural alterations animals resembling found sad patients valproic acid vpa histone deacetylase inhibitor hdaci recently shown regulate transcription several genes vivo vitro models alzheimer disease aim current study investigate potential effect different doses valproic acid icv stz induced animal model sad streptozotocin injected mice showed cognitive spatial memory dysfunction maze object recognition test morris water maze mwm neurobehavioral tests mice also exhibited decrease acetylcholine ach neprilysin nep levels accompanied increase acetylcholinesterase ache activity first time knowledge findings shown vpa capable restoring ach levels icv stz injected mice well normalizing nep levels ache activity via mechanism enhancement cognitive functions observed thus vpa suggested promising therapeutic approach sad
direct tension pull test astm astm astm others practical situ test assess bond strength materials bonded concrete substrate relatively although method prescribed number variations anecdotally seen practice may affect uniform interpretation test method results particular hypothesized shear normal stresses introduced drilling process damage sample affecting results disproportionately depth cut study systematically investigated hypothesis aim providing improved guidance associated depth indeed method core drilling preformed hand drilled core drilled specimens tested results compared additionally system applying controlled torsional moment specimens used quantitatively investigate effect force applied specimen preparation study also investigated effect using square cuts hand drilled core drilled specimens observed reduced pull capacity exhibiting reduction mpa depth mpa depth respectively increased core depth although attributed torsion may present drilling process square specimens exhibited marginally lower capacity comparable round specimens similar increased reduction capacity mpa depth cut finally discussion implications interpretation pull test results presented
increasing attention concern managing adverse effects adjuvant endocrine therapy women early breast cancer side effects therapy influence compliance impair quality life qol side effects associated tamoxifen tam aromatase inhibitors als directly related estrogen deprivation symptoms similar experienced natural menopause appear severe seen general population prolonged estrogen deprivation may lead atrophy vulva vagina lower urinary tract supporting pelvic structures resulting range genitourinary symptoms turn lead pain discomfort impairment sexual function negatively impact multiple domains qol genitourinary side effects may prevented reduced managed cases requires early recognition appropriate treatment provide overview practical clinical approaches understanding pathophysiology management genitourinary symptoms postmenopausal women receiving adjuvant endocrine therapy breast cancer
objective lymphedema one debilitating outcomes breast cancer treatment aimed compare demographic clinical characteristics breast cancer patients without lymphedema assess risk factors lymphedema evaluate treatment outcomes lymphedema patients materials methods demographic clinical characteristics women previous surgery breast cancer presented outpatient clinic march may retrospectively extracted patient records results upper extremity lymphedema detected patients mean age body mass index number positive lymph nodes number patients postoperative radiotherapy significantly higher among patients lymphedema without educational level patients lymphedema significantly lower group correlation analysis revealed association age educational level body mass index tumor stage number positive lymph nodes postoperative radiotherapy presence lymphedema postoperative radiotherapy detected independent risk factor logistic regression analysis fourteen lymphedema patients assigned education skin care exercise compression bandaging therapy upper extremity volumes volume differences significantly improved treatment conclusion advanced age low educational level obesity tumor size number positive lymph nodes postoperative radiotherapy correlated development lymphedema within factors postoperative radiotherapy detected independent risk factor development lymphedema patient education skin care exercise compression bandage therapy effective treatment options breast cancer related lymphedema
background although acupuncture highly effective treatment pain management suffers lack reproducibility results one many variables involved achieving reproducible clinical results specificity anatomical structure stimulated lack target specificity obscures scientific understanding acupuncture works leading skepticism efficacy acupuncture within medical community prejudice regarding wisdom imparted classical acupuncture texts objectives goals study test hypothesis classical acupoint locations described classics strong foundation neuroanatomy promote consensus among practitioners neuroanatomy based acupuncture methods acupoint locations described systematic classic transliterated acupoint neuroanatomical target determined literature review dissection electrical stimulation objective comparison made classical acupoint location acupoint descriptions contemporary chinese acupuncture textbook results classical acupoints specific neuroanatomical targets neuroanatomical differences acupoints found classical contemporary descriptions ten contemporary acupoints targets ambiguous missed corroborated neuroanatomical targets completely conclusions study demonstrates acupoint targets distinct nerve muscle enabling achievement feedback highly distinct tissue stimulation without target redundancy transmission erroneous ambiguous anatomical targets found contemporary texts highlights urgency advancing science based approach study neuroanatomical intents acupoints
purpose weight gain associated antipsychotics schizophrenia ongoing concern meta analysis examined efficacy safety amantadine adjunctive treatment weight gain schizophrenia systematically searching analyzing randomized controlled trials rcts rcts comparing adjunctive amantadine placebo adult patients schizophrenia included meta analysis methods two independent investigators searched literature extracted data weighted standardized mean differences wmds smds risk ratio confidence intervals calculated results five rcts double blinded design lasting weeks included analysis amantadine outperformed placebo regarding weight reduction moderate effect size trials wmd amantadine also outperformed placebo endpoint negative symptom positive negative syndrome scale panss trial scale assessment negative symptoms trial scores trials smd panss total scores trials smd positive symptom panss trial scale assessment positive symptoms trial scores smd except insomnia number needed harm confidence interval cause discontinuation risk ratio adverse events similar amantadine placebo groups conclusions according meta analysis rcts adjunctive amantadine seems effective option attenuating antipsychotic related weight gain patients schizophrenia rcts needed inform clinical recommendations
paper describes design multifunction second order voltage mode filter using voltage differencing differential difference amplifier vddda active element internal construction vddda based tsmc cmos technology used simulation testing proposed filter sort three inputs single output tiso multifunction filter consists single vddda single resistor two capacitors suitable fabricate monolithic chip filter provide five standard functions namely lowpass bandpass highpass band stop allpass responses circuit topology filter response selected digital method natural frequency quality factor electronically tuned attractive micro computer microcontroller controllability proposed filter supplied source simulated results using pspice simulation agree well expected theoretical analysis
key technical innovation needed close proximity hybrid ray xmr imaging systems new rotating anode ray tube motor operate presence strong magnetic fields order new motor design optimized conflicting design requirements implemented numerical model evaluating dynamics motor model predicts amount produced torque rotation speed time accelerate based lorentz force law motor accelerated interaction magnetic moments motor wire loops external magnetic field also includes empirical model bearing friction electromagnetic force magnetic field proposed computational model validated experiments using several different magnitudes external magnetic fields averagely shows agreement within error acceleration using model improve efficiency performance future iterations ray tube motor
antisocial personality disorder aspd psychopathy important syndromes substantial utility predicting antisocial behavior although prior studies identified correlations various factors presence psychopathy aspd studies focused syndrome consequently unclear whether syndromes reflect similar pathophysiologies whether fact distinct syndromes whether correlates aspd reflect high comorbidity psychopathy present study addressed issue examining impact aspd without comorbid psychopathy assessed psychopathy checklist revised criminal offending cognitive processing adult male inmates county jail illinois participants exhibited either aspd comorbid psychopathy aspd psychopathy neither aspd psychopathy participants without comorbid psychopathy characterized criminal behavior controls inmates aspd psychopathy exhibited severe criminal behavior aspd addition inmates aspd psychopathy exhibited different pattern cognitive task performance impairment aspd alone results replicate findings kosson lorenz newman provide new evidence suggesting men aspd comorbid psychopathy characterized cognitive processing anomalies different seen aspd without comorbid psychopathy
background aimswe published threatening life experiences adverse family relations impact crohn disease adversely study examine influence stressors ulcerative colitis patients methodspatients completed demography economic status patient simple clinical colitis activity index sccai short inflammatory bowel disease questionnaire sibdq short form health survey brief symptom inventory bsi family assessment device fad list threatening life experiences lte analysis included multiple linear quantile regressions structural equation modeling comparing resultsuc patients age years women scores median interquartile range follows scaai fad lte physical health mental health brief symptom inventory global severity index gsi sibdq significant positive associations lte scaai quantiles fad mental health fad lte gsi quantiles sibdq negative associations follows lte physical mental health sibdq fad lte gsi quantiles sccai quantiles structural equation modeling analysis lte impacted negatively impacted gsi negatively lte impacted gsi positively gsi impacted sccai positively split model greater effect gsi whereas path magnitudes similar conclusionthreatening life experiences adverse family relations poor make patients less healthy physically mentally impact worse copyright wolters kluwer health inc rights reserved
paper aims proposition novel architectures radial basis function neural networks implementation hardware custom precision floating point operations black box system modeling analysis tool built establish trade consumption hardware resources precision outputs basis usage logic blocks field programmable gate array output quality architectures tested standard system identification benchmark speedup factors compared implementation order hundreds shows importance hoc hardware architectures improving computational efficiency
purpose purpose integrative review evaluate synthesize studies incorporated biological measures examined associations chronic stress anxiety adolescents emerging adults chronic health conditions design integrative literature review conducted using preferred reporting items systematic reviews meta analyses statement identify studies published methods using key terms three databases pubmed medline psycinfo cumulative index nursing allied health literature searched research librarian additional publications relevance topic identified citing cited literature full text publications reviewed final group articles analyzed review included peer reviewed publications meeting abstracts findings studies varied considerably characteristics theoretical frameworks phenotypes interest study measures studies evaluated genomic variants often examined small samples limited number biological factors conclusions studies chronic stress anxiety adolescents emerging adults chronic health conditions currently limited scope impact comprehensive approach facilitate translation practice improve short long term health outcomes clinical relevance precision genomic healthcare initiatives support relevance work nurses areas clinical practice genomic testing expanding include individuals age groups without diagnosed conditions psychological behavioral phenotypes may influence self management outcomes adolescents emerging adults chronic health conditions research area warranted
development optics computer technologies enables application vision based technique uses digital cameras displacement measurement large scale structures compared traditional contact measurements vision based technique allows remote measurement non intrusive characteristic necessitate mass introduction study high speed camera system developed complete displacement measurement real time system consists highspeed camera notebook computer high speed camera capture images speed hundreds frames per second process captured images computer lucas kanade template tracking algorithm field computer vision introduced additionally modified inverse compositional algorithm proposed reduce computing time original algorithm improve efficiency modified algorithm rapidly accomplish one displacement extraction within without install pre designed target panel onto structures advance accuracy efficiency system remote measurement dynamic displacement demonstrated experiments motion platform sound barrier suspension viaduct experimental results show proposed algorithm extract accurate displacement signal accomplish vibration measurement large scale structures elsevier ltd rights reserved
introduction familiarity coping strategies essential stress management pregnancy revised prenatal coping inventory pci developed assess coping strategies pregnancy aim study aimed assess factor structure psychometric properties persian version pci materials methods forward backward translation pci administered pregnant women enrolled two teaching referral clinics north islamic republic iran babol participants completed persian pci ways coping questionnaire wcq used determine validity persian pci test construct validity persian pci principal components factor analysis performed results principal components analysis varimax rotation showed best fitting factor structure similar original three coping subscales planning preparation avoidance spiritual positive coping persian pci internally consistent within acceptable range alpha alpha coefficients pci subscales planning preparation avoidance spiritual positive coping high test retest coefficients pci subscales pci subscales correlated wcq entire sample within trimester conclusion persian version pci subscales planning preparation avoidance spiritual positive coping represent first reliable standardized tool measuring coping strategies pregnancy islamic republic iran therefore applied quick accurate preliminary screening tool evaluating coping strategies throughout pregnancy clinics medical research settings
multi label classification instance associated multiple relevant labels goal predict labels simultaneously many real world applications multi label classification come different performance evaluation criteria thus important design general multi label classification methods flexibly take different criteria account methods tackle problem cost sensitive multi label classification csmlc existing csmlc methods either suffer high computational complexity focus certain specific criteria work propose novel csmlc method named progressive random labelsets prakel resolve two issues method extended popular multi label classification method random labelsets hence inherits efficiency furthermore proposed method handle arbitrary example based evaluation criteria progressively transforming csmlc problem series cost sensitive multi class classification problems experimental results demonstrate prakel competitive existing methods specific criteria optimize superior criteria
paper novel operational amplifier demonstrated established folded cascode amp structure new technique positive feedback proposed increase open loop gain amp limiting linearity proposed structure simulated hspice software using level parameters bsimv typical cmos technology hspice simulation verifies theoretical estimated improvements
autism spectrum disorders asds encompass range syndromes characterized social interaction impairments verbal nonverbal communication difficulties stereotypic repetitive behaviours although considerable progress understanding mechanisms underlying changes social communicative aspects asd neurofunctional architecture repetitive stereotypic behaviours well cognitive domains related response action control remain poorly understood based findings neurobiological neuroanatomical alterations asd functional neuroanatomy neurobiology different action control functions emphasize changes action control processes including response inhibition conflict response monitoring task switching dual tasking motor timing error monitoring important facets asd processes must examined understand executive control deficits asd related stereotypic repetitive behaviours major facet asd review shows domains action control strongly affected asd several factors seem determine consistency alterations cognitive control reported factors relate relevance neurobiological changes asd cognitive domains examined far action control relies upon adjustment prior experience future directions hypotheses outlined may guide basic clinical research action control asd elsevier ltd rights reserved
thyroid hormone essential metabolism nerve excitability physical development congenital hypothyroidism leads dysfunction neuronal migration thyroid hormone deficiency even delays psychomotor formation development serious congenital hypothyroidism congenital hypothyroidism presents higher rate incidence infants common causes mental retardation fibroblast growth factors fgf endogenous metabolism regulate factor increases energy consumption reduces blood lipid triglyceride low density lipoprotein levels enhances capacity fat cells absorb glucose suppresses glucagon secretion purpose study investigate changes fgf level efficacy fgf mice congenital hypothyroidism therapeutic efficacy fgf conducted intravenous injection manner congenital hypothyroidism mouse model therapeutic outcomes fgf mice congenital hypothyroidism assessed animals behaviours results found fgf levels significantly lower serum thyroid congenital hypothyroidism mouse model healthy subjects observed tsh regulated thyroid fgf treatment serum levels fgf fgf concentration thyroid higher control groups treatment fgf serum levels fgf thyroid positively related thyroid stimulating hormone tsh thyroxine respectively multiple linear regression analysis showed hypothyroidism fgf decreased independent factors influencing serum tsh levels taken together provided evidence protein diagnosis potential efficacy fgf congenital hypothyroidism
aim review identify etiological environmental factors related incontinence children adults variety etiological environmental factors development incontinence identified children encompass stressful life events trauma family dysfunction parental psychopathology school related stressors toilet potty training fluid consumption habits housing conditions availability toilets adults physical exercise obesity working conditions fluid intake availability toilets play role intervening variables hormonal variations due work shifts also identified influencing likelihood incontinence current research suggests environmental factors influence development incontinence children adults interactions biological factors immediate environment intervening variables need explored greater detail practical solutions reduce barriers adequate fluid intake healthy toileting habits implemented school work settings
present study provides insight heterogeneous response glaciers lidder sindh river basins western himalaya explores linkages glacier facies variability changing glacier parameters results show region undergone overall deglaciation similar fluctuations temperature precipitation patterns seem primary factor controlling changes glacier dimensions cases glacier facies changes suggest depletion snow ice cover similar increase ice mixed debris similar supraglacial debris similar periglacial debris similar glacier facies transitions possibly result ice melting however relative rate elevation decides nature facies conversion increase proportion supraglacial debris led conversion clean glaciers sparsely debris covered glaciers sparsely debris covered glaciers debris covered glaciers size glaciers greatly influenced rate conversion glaciers glaciers dominated others regard small glaciers also experienced maximum shrinkage glaciers varying supraglacial debris cover respond differently sparsely debris covered glaciers exhibit highest rates retreat followed clean debris covered glaciers thus findings work clearly show climate change driven dimensional changes glaciers variations spatial distribution glacier facies strong mutual control elsevier rights reserved
women couples continue experience unintended pregnancies high rates pregnancies either mistimed unwanted mishaps contraceptives condom breakage missed pills incorrect timing patch vaginal ring application contraceptive nonuse forced intercourse circumstances place women risk unintended pregnancy critical role emergency contraception preventing pregnancies currently three methods available levonorgestrel pills available prescription years counter since ulipristal acetate pills became available prescription finally copper intrauterine device remains effective form use increasing time due wider availability accessibility methods one strategy expand access prescription nonprescription products include pharmacies point access allow pharmacist prescribing eight states pharmacists able prescribe provide directly women levonorgestrel eight states ulipristal acetate seven states addition access prescription written pharmacist health care provider levonorgestrel available counter pharmacies grocery stores pharmacists play critical role access community pharmacies ensuring product availability inventory date knowledge comprehensive patient counseling looking future opportunities expand access pharmacies implementing legislation expanding pharmacist scope practice ensuring third party reimbursement clinical services delivered pharmacists including pharmacy education training
acetylcholinesterase inhibitors regarded promising therapeutic agents treat addiction current study aimed examine effects huperzine cholinesterase inhibitor behavioral sensitization induced repeated morphine administration relapse induced contextual conditioning present study also assessed whether state dependency hypothesis may explain results adult rats divided four groups intraperitoneally injected huperzine saline control days effect repeated huperzine administration alone locomotor activity assessed experiments analyzed development morphine induced sensitization rats divided five groups saline saline saline morphine huperzine morphine following withdrawal period days animals administered saline morphine appropriate test state dependency hypothesis rats saline morphine group injected saline morphine three groups administered different doses huperzine morphine examine effect huperzine expression morphine induced sensitization rats huperzine morphine groups injected appropriate concentrations huperzine morphine current results indicated administration huperzine alone affect locomotor activity higher doses huperzine inhibited addictive behavior induced morphine development phase additionally huperzine administration expression phase morphine sensitization inhibit relapse induced administration saline furthermore huperzine inhibited expression morphine induced behavioral sensitization therefore results current study support state dependency hypothesis
background exercise related leg pain erlp common lower limb overuse injury characterised pain located knee ankle occurs activity high incidence condition subsequent interference participation physical activity substantial recovery time highlights need effective interventions whilst many interventions described management erlp currently lack high quality evidence effective intervention condition methods design single blinded randomised controlled clinical trial conducted community setting forty five female volunteers aged years history insidious onset pain located knee ankle least one month duration aggravated weight bearing activities recruited study suitable participants randomly allocated one three treatment groups week intervention period exercise rigid anti pronation tape exercise iii elastic anti pronation tape exercise outcomes measured baseline weeks using primary outcome measures usual worst pain visual analogue scale global perceived improvement secondary outcome measures include foot ankle ability measure patient specific functional scale amount activity previous week addition participants contacted phone obtain primary secondary outcome measures weeks discussion article describes single blinded randomised controlled clinical trial utilise high quality methodologies accordance consort guidelines results study contribute limited knowledge regarding effective interventions management erlp
micrornas mirnas nucleotides long non coding rnas known play important regulatory roles biotic abiotic stresses controlling gene expression blackgram vigna mungo economically important grain legume highly susceptible pathogenic begomovirus mungbean yellow mosaic india virus mymiv resulting high yield loss study two different leaf small rna libraries prepared pooled rna three different time points resistant mungo inbred line inoculated either viruliferous non viruliferous whiteflies carrying mymiv performed high throughput illumina sequencing sequencing followed bioinformatics analysis small rna reads indicated expression patterns known novel mirnas altered resistant line mock inoculated sample plant virus incompatible interaction highly altered mirnas belong families mir mir mir mir mir mir mir mir novel vmu mirn vmu mirn vmu mirn vmu mirn results validated using qpcr mirnas showed similar pattern expression like illumina reads expression patterns selected known novel mirnas also compared infected mymiv resistant susceptible genotypes modulated mymiv inoculation target transcripts like lrr nac myb zinc finger ccaat box transcription factor fructose bisphosphate hdzip protein confers immune response predicted targets amongst identified mirnas using psrnatarget server selected target transcripts including lrr arf sod spb basic blue copper protein validated differential expression demonstrated mymiv resistant susceptible mungo qpcr data analyses present study identified mirnas implicate regulation mymiv induced stress response mungo generated genomic resources non model legume aid bioinformatics tools supplemented experimental validation elsevier rights reserved
traumatic brain injury injury brain parenchyma resulting external factors vehicular accidents falls sports injuries outcome involves primary insult followed cascade secondary insult resulting diffuse axonal injury causing white matter damage surgical intervention targets primary damage whereas treatment alternatives available treat secondary damage cellular therapy could one prospective therapeutic options potential arrest degeneration promote regeneration new cells brain conducted pilot study cases administered autologous bone marrow mononuclear cells intrathecally follow done week months months intervention functional independence measure scale health survey scoring disability rating scale used outcome measures scales showed positive shift scores end months improvements observed various symptoms along activities daily living improvement pet scan performed months intervention patients corresponded clinical functional improvements observed patients results study suggest cell therapy may promote functional recovery leading improved quality life chronic tbi although results positive improvements cell therapy optimal hence additional multicenter controlled studies required establish cell therapy standard therapeutic approach
computer programming important competence engineering computer science students teaching learning programming concepts skills recognized big challenge teachers students accordingly researchers indicated learning strategy lack study lack practice causal attributes success failure computer programming course therefore cope problem interactive test system proposed enhance students learning outcomes computer programming courses study experiment conducted college computer programming course evaluate effectiveness proposed method experimental results show proposed approach benefit students enhancing programming skills addition students attitudes toward learning computer programming improved
internet multimedia streaming quality delivered media adapted quality service provided underlying network thanks encoding algorithms allow fine grained enhancement low quality base layer streaming time main objective satisfied systems avoid starvation decoding process consequent playout interruptions work tackle problem using control theoretic approach particular design implement novel end end quality adaptive scheduler properly distributing network available bandwidth among base enhancement layers developed solution adopted many contexts given designed without assumptions delivered media protocol stack anyway test effectiveness casted avc svc based video streaming architecture unicast internet applications performance scheduler experimentally evaluated controlled testbed several wild internet scenarios including also umts satellite radio links results clearly demonstrated quality adaptive scheduler able significantly improve performance video streaming system operative conditions elsevier inc rights reserved
office adolescent health oah developed systematic approach review medical accuracy educational materials proposed use teen pregnancy prevention tpp programs process also used administration children youth families acyf review materials used personal responsibility education innovative strategies preis program article describes review process explaining methodology team implementing reviews process distributing review findings implementing changes provided also definition medically accurate complete used programs description constitutes complete information discussing sexually transmitted infections birth control methods article interest program providers curriculum developers purveyors interested providing medically accurate complete information adolescents published elsevier inc behalf society adolescent health medicine
paper presents approach measure characterize simulate photometric performances light transmission efficiency innovative transparent concrete panel facades transparency obtained texture pmma resin insertions fiber reinforced concrete panel first part paper integrating sphere measurements collected derive spectral optical properties panel optical properties specimen measured incidence angles normal degrees spectral results reported data collected measures used create validate simplified radiance model panel optimize simulation parameters estimate properly total internal reflections effects thought pmma resin insertions authors published elsevier ltd
patients borderline personality disorder bpd high risk suicidal behavior however many bpd patients engage suicidal behavior study compared clinical features bpd patients without history suicide attempts healthy volunteers compared healthy volunteers bpd groups higher affective lability scale als als depression anxiety subscale barratt impulsivity scale bis lifetime history aggression lha scores likely history temper tantrums bpd suicide attempters higher als als depression anxiety subscale lha scores likely history non suicidal self injury temper tantrums compared bpd nonattempters also bpd suicide attempters likely history comorbid major depressive disorder less likely comorbid narcissistic personality disorder npd comparison bpd nonattempters study participants bpd group history comorbid substance use disorder sud study indicates bpd patients history suicide attempt aggressive affectively dysregulated less narcissistic bpd suicide non attempters
demand obtain accurate high efficiency hydraulic actuator increasing heavy industries however existence uncertain nonlinear unknown terms system dynamics limits performance hydraulic actuator significantly deal problems paper proposes advanced control approach named integrated model based backstepping ibs controller position tracking control pump controlled electro hydraulic system pehs first mathematical model studied system fully derived structure system elements clearly presented second realize control performance transient steady state responses simplify design procedure advanced backstepping technique employed compensate nonlinearities unknown terms uncertainties well treated novel identification method based obtained model third stability closed loop system theoretically maintained using lyapunov functions finally effectiveness feasibility proposed method confirmed comparing tuned proportional integral derivative pid controller direct backstepping dbs controller real time tracking control pehs follow various trajectories different testing conditions
widely recognized public key cryptosystems playing tremendously important role providing security services majority cryptosystems crucial arithmetic operation modular exponentiation composed series modular multiplications hence performance cryptosystem strongly depends efficient implementation operations paper presents bit forwarding bits bfw technique efficient implementation modular exponentiation modular multiplication involved bfw evaluated help montgomery method techniques improves performance reducing frequency modular multiplications results shows bfw technique able reduce frequency multiplications bit exponent reduction resulted increased throughput comparison mme cost extra area power consumption reduced thereby saving energy
illegal deforestation worldwide problem may alleviated technological means deforestation monitoring wireless sensor networks capable identifying chain saw noise performing sound source localization ssl alerting authorities location illegal deforestation activity paper evaluate feasibility performing ssl low power energy constrained microphone array equipped sensor nodes sns delay sum beam forming algorithm work first application technique chain saw noise evaluate array configurations microphones multitude algorithm configurations utilizing chain saw recordings esc dataset available online implement algorithm digital circuit xilinx spartan fpga analyze energy consumption analysis indicates accurate chain saw localization achieved much simpler microphone arrays configurations compared previous work furthermore adding fpga based ssl capability increases energy consumption less compared baseline capable chain saw identification spectral analysis executed software microcontroller elsevier ltd rights reserved
privacy preserving distributed machine learning becomes increasingly important due recent rapid growth data paper focuses class regularized empirical risk minimization machine learning problems develops two methods provide differential privacy distributed learning algorithms network first decentralize learning algorithm using alternating direction method multipliers propose methods dual variable perturbation primal variable perturbation provide dynamic differential privacy two mechanisms lead algorithms provide privacy guarantees mild conditions convexity differentiability loss function regularizer study performance algorithms show dual variable perturbation outperforms primal counterpart design optimal privacy mechanism analyze fundamental tradeoff privacy accuracy provide guidelines choose privacy parameters numerical experiments using customer information database performed corroborate results privacy utility tradeoffs design
misfolding aggregation alpha synuclein alpha syn resulting cytotoxicity hallmark parkinson disease related synucleinopathies recent body evidence indicates alpha syn released neuronal cells nonconventional exocytosis involving extracellular vesicles evs exosomes transfer alpha syn cells proposed important mechanism disease propagation date exosome trafficking mechanisms including release cell cell transmission fully described gain insight mechanisms involved exosomes purified conditioned media stable cells secreting alpha syn oligomers novel bimolecular protein complementation assay used detect exosomes containing alpha syn oligomers recipient cells treated exosomes containing alpha syn oligomers free non exosome associated alpha syn oligomers internalization monitored demonstrate cell derived exosome associated alpha syn oligomers efficiently internalized recipient cells interestingly exosome free alpha syn oligomers isolated conditioned medium internalized remained bound extracellular surface investigate endocytic pathway required exosome uptake different pharmacological inhibitors caveolin dependent clathrin dependent macropinocytosis pathways utilized surprisingly none pathways appear play significant role internalization exosome associated alpha syn oligomers finally role heparin sulfate proteoglycans hspgs exosome associated alpha syn internalization investigated using genetic approach despite previous studies showing hspgs modulate internalization fibrillar alpha syn genetic manipulations attenuate internalization exosome associated alpha syn oligomers hands suggesting exosome associated syn internalized via alternative endocytic pathway yet elucidated
actuated spatial universal rotating magnetic vector digital control steering navigation spiral type capsule robot gastrointestinal tract becomes possible however potential risk fluid resistance torsion moment generated rotating spiral type capsule robot would distort tract insufficient fluid difficult investigate fluid distorting effect tract online measurement fluid resistance torsion moment still remains unsolved paper innovative method employing critical coupling magnetic moment indirectly detecting fluid resistance torsion moment proposed reduce fluid distorting effect petal shaped capsule robot whose surface composed four petal shaped tiles proposed fluid resistance torsion moment weaken effect petal shaped capsule robot discovered investigated happens fluid travels convergent wedge like gap surface four petal shaped tiles inner pipe wall simulations experiments demonstrated twist impact tract petal shaped capsule robot reduced non contact driving performance tract improved greatly isolated fluid membrane high dynamic pressure
electric motors power drive systems convert nearly half worldwide electric energy mechanical energy ultimately used tinal application process overall motor driven system optimization key approach effectively achieve highest system efficiency levels given investment looking individually component may lead cost effective option terms investment part paper overview motor driven system optimization presented looking relevant related standards commercial technologies energy consumption reduction strategies collection practical examples also presented part overview international standards associated high efficiency technologies power drive systems presented part energy savings potential associated output power reduction regeneration addressed
slope instability due rainwater infiltration poses serious problem causes thousands deaths severe damage infrastructures year present study effect inclusion hybrid geosynthetic layers within slope subjected rainfall investigated numerically analysis done without hybrid geosynthetic layers embedded silty sand slope inclination rainfall intensities ranging rainfall simulated numerically seepage deformation stability analyses performed onset rainfall rainfall rainfall need drainage reinforcement function reinforced slope highlighted analysing effect geotextile geogrid layer inclusions separately slope subjected rainfall results indicate inclusion hybrid geosynthetic layers effective lowered phreatic surface causing reduction excess pore water pressure static global stability hybrid geosynthetic reinforced slope found increase considerably intensities rainfall deformation values significantly lower reinforced slope compared unreinforced slope
intellectual spiritual ambition catholic church seen popular work late medieval catholic lay piety werke housholders written bridgettine richard whitford medium print lay english audiences exposed intellectual spiritual innovations cultivate interior acts devotion householders addressed aspirations towards developing interior personal acts devotion sat beside messages household governance emotional management gender roles refocusing attention household aspirations late medieval early modern lay households article adds known late medieval catholic vitality whitford text also provides puzzling piece evidence evolving nature late medieval catholic devotion reformed spirituality early reformation article concludes posing questions complexity pre post reformation religious vision loyalty individual religious figures early modern period
objective examine concurrent longitudinal associations sleep duration body mass index bmi adolescence young adulthood controlling physical activity internalising symptoms sex age group differences early adolescent group ages years late adolescent group ages years examined design randomly selected community based sample youth males surveyed biannually results found sex age group differences concurrent longitudinal associations bmi males shorter baseline concurrently related higher bmi females shorter baseline associated longitudinal increases bmi late adolescent group conclusion findings show association bmi previously shown childhood continues significant adolescence young adulthood developmentally appropriate sex specific strategies motivating supporting healthy sleep habits adolescence may help prevent weight gain young adulthood discussed
stellarator fusion experiment wendelstein presently assembly greifswald branch max planck institute plasma physics germany superconducting magnet system basically consists nonplanar planar coils including interconnecting bus bars support structure seven electrical circuits coils series supplied current leads cls operating cryogenic ambient temperature environments special feature feedthroughs upside orientation save space vicinity machine basic electrical requirements maximal steady state currents voltage strengths ground consists copper conductor also acts heat exchanger warm end side continuation high temperature superconductor part cold end side copper bar integrated nbsn rods components fully contained within vacuum chamber separated main cryostat vacuum high voltage electrical insulation built glass tape epoxy resin system mechanical support cls achieved warm cold glass fiber reinforced plastic flange three cooling circuits one bus bar contact cooling one cold end one cls heat exchanger entrance temperature intensive tests two prototypes series production established completed cls tested room temperature helium leaks instrumentation etc electrical currents maximum current cryogenic temperatures paper gives overview basic design requirements layout well fabrication acceptance tests furthermore description assembly progress given
framework development unified computational tool needs biomedical optics introduce electric field monte carlo model simulation backscattering coherent linearly polarized light turbid tissue like scattering medium rough surface consider laser speckle patterns formation role surface roughness depolarization linearly polarized light backscattered medium mutual phase shifts due photons pathlength difference within medium due reflection refraction rough surface medium taken account validation model includes creation phantoms various roughness optical properties measurements cross polarized components backscattered reflected light analysis extensive computer modeling accelerated parallel computing nvidia graphics processing units using compute unified device architecture cuda analysis spatial intensity distribution based second order statistics shows strong correlation surface roughness results modeling experiment results modeling show good agreement results experimental measurements phantoms mimicking human skin developed approach used direct simulation light scattered turbid scattering medium various roughness surface society photo optical instrumentation engineers spie
chitin based polyurethane trcpu organogel composed isophorone diisocyanate ipdi polyethylene glycol peg chitin shown undergo temperature dependent sal gel transition polar organic solvents soft segments prepolymer originated peg imparted elastomeric hydrophilic characteristics trcpus hard segments chitin ipdi contained highly polar urethane linkages acted physical alignment sites provided lipophilic characteristics trcpus polar organic solvent average molecular weight degree acetylation chitin determined based intrinsic viscosity solid state mas nmr spectrum chitin incorporated polyurethane via covalent bonding resultant copolymer injectable organosol low temperatures transformed semisolid organogel approximately degrees trcpus characterized nmr dsc theological behavior trcpu solutions organic solvents studied elsevier ltd rights reserved
background regular physical activity important health benefits children type diabetes mellitus tdm yet children parents face barriers participation lack self efficacy concerns around hypoglycaemia multimedia interventions useful educating children health demonstrate potential improve children health related self efficacy paediatric clinics offer web based resources part routine care steps active kids diabetes stak programme online intervention grounded psychological theory social cognitive theory informed extensive preliminary research aim programme encourage support safe engagement physical activity children tdm aim research explore feasibility delivering stak programme children aged years tdm assess feasibility research demonstrate clinical cost effectiveness methods children aged years tdm parents recruited two paediatric diabetes clinics child parent dyads randomised intervention group access intervention website stak wrist worn activity monitor months feasibility intervention research assessed rate recruitment adherence retention data completion adverse events qualitative interviews undertaken subsample children parents dyads health care professionals health outcomes feasibility outcome measurement tools assessed include self efficacy csappa objective physical activity self reported physical activity paq fear hypoglycaemia chfs phfs glycaemic control hbac insulin dose body mass index bmi health related quality life chud chq health service use patient clinician communication assessments taken baseline weeks month follow discussion goal feasibility trial assess delivery stak promote physical activity among children tdm assess potential definitive research demonstrate effectiveness results provide information necessary design larger randomised controlled trial maximise recruitment rate intervention delivery trial retention
activity hypothalamus pituitary thyroid axis hpt coordinated hypophysiotropic thyrotropin releasing hormone trh neurons present paraventricular nucleus hypothalamus hypophysiotropic trh neurons act energy sensors trh controls synthesis release thyrotropin activates synthesis secretion thyroid hormones target tissues transporters deiodinases control local availability thyroid hormones regulate many functions including energy homeostasis review discusses recent evidence covers several aspects trh role hpt axis regulation knowledge mechanisms trh signaling steadily increased new transcription factors engaged trh gene expression identified advances made interact signaling pathways define dynamics trh neurons response acute long term influences albeit yet incomplete relationship trh neurons activity positive energy balance emerged importance tanycytes central relay feedback control axis well hpt responses alterations energy balance stimuli reinforced finally studies started shed light interference prenatal postnatal stress nutrition hptaxis programing confirmed axis susceptibility early insults
background date research revictimization mainly focused sexual revictimization revealing childhood sexual abuse increases risk exposure sexual violence adulthood occurring physical abuse childhood similarly increases risk sexual revictimization however research gap concerning physical revictimization specific effect different forms child abuse sexual physical emotional revictimized objective present study aims investigating specific relationship different subtypes childhood abuse different forms exposure violence adulthood method female participants aged years completed online questionnaires capturing sexual physical emotional abuse histories child adulthood well current symptoms posttraumatic stress disorder ptsd depression results linear regression analysis revealed sexual physical childhood abuse specific predictors sexual victimization adulthood standardized beta coefficient respectively physical emotional maltreatment hand specifically associated physical victimization adulthood standardized beta coefficient respectively conclusion basis present findings assume particular subtypes childhood abuse associated increased risk experiencing specific forms violence adults result important clinical implications particular respect development effective treatment prevention programs survivors childhood abuse
background timely diagnosis invasive fungal infections ifi renal transplant patients immunosuppression often difficult jeopardizing life graft reported ifi causative fungal agents post patients materials methods retrospective year clinical study carried patients clinical data included patient donor demographics time onset infection risk factors graft function terms serum creatinine scr identify ifi examined bronchoalveolar lavage bal blood tissue wound swab samples conventional mycological methods results ifi diagnosed patients triple immunosuppression mainly males mean age years months post aspergillus species identified bal one tissue one wound specimen fatal caused graft loss candida albicans nine bal four blood two wound swab one tissue specimens fatal graft loss one mucor bal fatal seven patients diabetic superadded cytomegalovirus infection anti rejected conclusion ifi associated increased morbidity mortality patients triple immunosuppression broad spectrum antibiotics two weeks diabetes superadded infection added risks patients prevention early diagnosis appropriate management necessary improve prognosis
healthcare experiences among women living hiv aids wlha determine utilisation sexual reproductive health services ultimately influences decisions childbearing study aimed understand importance healthcare support childbearing decision making processes wlha impact eliminating new paediatric hiv infections conducted depth interviews july august wlha receiving clinical hiv care teaching hospital lagos using pen cultural model guide explored perceptions healthcare support pre post partum findings indicate faith god delivery healthy child significant pre partum period advice healthcare workers concerning childbearing access available healthcare services carry weight post partum findings important implications hiv treatment care programmes geared towards wlha considering childbearing ultimately global plan eliminate mother child transmission hiv move towards agenda sustainable development
background aged skin sum chronological und induced aging light exposed skin unattractive irregular pigmentation roughness und scaliness skin often dry itches methods present paper provides overview diseases aging skin describes prevent reduce disease prophylactic therapeutic skin care results aged skin develop several skin diseases different types eczema skin cancer body folds often find irritant contact eczema caused friction skin skin sweating urinary fecal incontinence bedridden bed sores also develop furthermore delay wound healing owing old age use adequate creams ointments helpful preventing improving skin diseases mature skin however knowledge aged people healthcare professionals importance skin care low older people often unable care skin lacking physical mental ability conclusion healthcare professionals sufficiently trained value proper skin care adequate studies role skin care selection correct preparation various aged related diseases lacking
research aimed determine effect food insecurity sexual hiv risk clients among youth sex workers ysws years metro vancouver canada data drawn prospective community cohort sex workers examined independent relationship ysws food insecurity pressured sex without condom clients client condom refusal ysws reported client condom refusal year study period reported food insecurity adjusting hiv risk pathways food insecurity retained independent effect client condom refusal aor suggesting food insecurity significantly associated hiv risk among ysws study indicates critical relationship food insecurity hiv risk demonstrates ysws particular vulnerability public policies food assistance harm reduction measure may key addressing disparity
integration integrated circuits continues rise feature size integrated devices entered nanometer single electron transistor set satisfied nanoelectronic devices set mixed composition nano mos devices setmos one hot current study setmos new hybrid device combine advantages also coulomb oscillation characteristics set mos high gain integrated analog signal processing filters basic unit circuit must conform development times based characteristics setmos hybrid device model setmos integrator designed expounding operating condition structure performance parameter characteristics transmission performance integrator designed simulated spice conclusion proved simulation result
noise unstable power supply influence sensing results classic charge transfer based capacitive touch sensing methods sensing methods implemented devices share power supply heavily changing loads sensing methods inclined fail brownout paper proposes inverse charge transfer sensing method applied low power quality situation proposed method includes reference channel sensing capacitors sensing channels reference channel precharged terminal voltage therefore inconsistencies sensing results induced low power quality compensated using reference channel experimental result indicates proposed method exhibits excellent touch signal noise ratio improvement switching noise case brownout case able distinguish touched untouched state brownout case
environmental justice research seeks document redress disproportionate environmental burdens benefits associated social inequalities although initial focus disparities exposure anthropogenic pollution scope research expanded context intensifying social inequalities environmental problems need strengthen research framework diversify application special issue international journal environmental research public health ijerph incorporates articles broaden research considering emerging topics energy food drinking water flooding sustainability gender dynamics including issues canada eastern europe additionally articles contribute three research themes documenting connections unjust environmental exposures health impacts examining unsafe infrastructure substance use children obesity academic performance promoting achieving implementing interventions improve environmental knowledge health identifying avenues sustainable community change incorporating metrics government programs clarifying stakeholder perceptions issues extend research beyond documentation unjust conditions processes collectively articles highlight potentially compounding injustices array approaches employed achieve
purpose impact isolated malleolar fractures intra articular load distribution within ankle joint studied several biomechanical cadaver studies last decades recently computed tomography osteoabsorptiometry oam proposed valuable tool assess intra articular joint load distribution vivo purpose retrospective matched pair analysis apply oam evaluate vivo changes talar load distribution lateral malleolar fractures patients treated open anatomic reduction internal fixation orif compared patients treated non operatively methods ten matched pairs patients isolated lateral malleolar fractures maximum fracture dislocation median follow month included study patients matched age gender fracture dislocation range ankle motion rom aofas hindfoot score short form evaluated oam analysis injured uninjured contralateral ankles performed results patients treated orif showed significant lower rom compared uninjured contralateral ankle differences found regarding clinical scores patients treated orif treated non operatively oam analysis showed symmetrical distribution subchondral bone mineralization comparison uninjured contralateral ankles groups patients conclusions data study suggest isolated lateral malleolar fractures fracture gaps associated change tibio talar joint load distribution vivo therefore patients isolated minimally displaced lateral malleolar fractures may achieve good clinical long term outcome following non operative treatment elsevier ltd rights reserved
national science foundation nsf sponsored project initiated department mechanical manufacturing engineering mme miami university aim creating online learning modules increase efficacy coursework modules designed instil proficiency computational experimental analysis grouped along five thematic lines form subject studios modules contain multimedia content designed use supplementary course material independently students preparation research tasks review specific concepts prior courses used augment existing courses salient feature modules ability introduce lab experiment derived content lecture course formats found particularly effective engaging students enabling introduction new topics minimal disruption existing daily syllabus course project development implementation phase end mid year since assessment continuous improvement integral parts project paper presents data two year assessment process describes changes project paper also includes discussion plans expansion modules practices keeping content current
work report structural mechanical magnetic properties mechanically alloyed feco powders alloying formation grain size lattice parameter internal strain investigated using ray diffraction xrd measurements morphological aspect nanostructured powders analysed means scanning electron microscopy sem compacted pastilles circular shape vickers test micro hardness magnetic measurements hysterisis loops discussed results according milling time show milling grain refinement internal strain around micro hardness increases decrease grain size hysterisis loop milling enhanced term decreased coercivity
noise induced quantization digitally controlled systems modelled small amplitude chaotic behaviour described simple piecewise linear map micro chaos map chaotic nature certain micro chaos maps proved rigorously last years also pointed several disconnected strange attractors repellers may coexist far desired state system control error influenced number strange sets local behaviour trajectories neighbourhoods present paper focus exploration possible attractor repeller structures phase space controlled system estimate expected control error several methods
increasing applications ionic liquids ils toxicity ils drawn increasing attention recent years especially influences different anions alkyl chain lengths acute toxicity aquatic organisms performed study acute toxicity alkyl methylimidazolium nitrate mim hexyl methylimidazolium ils mim zebrafish danio rerio also evaluated sensibility investigated animals stability ils water via high performance liquid chromatography hplc agilent agilent technologies inc usa prove reliability present study results illustrated test zebrafish danio rerio sensitive reference toxicant investigated ils water stable lethal concentration used represent acute toxicity zebrafish dario rerio present study showed highest toxic mim lowest toxic mim danio rerio ils different anions similar values accordingly believe ils different alkyl chain lengths cause greater effects anions acute toxicity aquatic organisms furthermore present study also provide scientific methods future studies select assess ils
paper seeks examine characteristics importance heat transfer phenomena combustion chamber walls cylinder pressure combustion chamber wall temperature measured motored fired conditions spark ignition engine parameters measured constant engine speed rpm different ignition timings phi separately lpg gasoline hydrogen cooling loss heat release investigated different heat transfer equations three fuels also cooling loss hydrogen compared fossil fuels investigate differences heat transfer values correction constant required fuel determined using different heat transfer equations findings study suggest proposed model better prediction results eichelberg heat transfer coefficient equation burnt specific heat ratio equation ignition timings fuels
current paper presents engineering approach studies control algorithm designed mechanically robust large antenna feed forward control methods order polynomial tracking algorithm supplemented original feed back pid control system dynamical model existing servo system radio telescope developed widen case analysis observation sessions efficiency control algorithms due limited access antenna algorithms along results system implemented real antenna well model results presented
peroxisome proliferator activated receptor gamma ppar ligand dependent transcription factor plays important role regulating glucose metabolism agonists ppar thiazolidinediones anti hyperglycemic activity therefore used treat type diabetes however functional activity ppar manifested heterodimers ppar retinoid receptors rxrs since rxr ppar heterodimers activated ppar agonists also rxr agonists rxr agonists also attractive candidates treatment type diabetes however rxr full agonists side effects triglyceride elevation hypothyroidism therefore rxr partial agonists developed new anti type diabetes agent candidates reduced side effects addition rxr antagonists also show therapeutic potency type diabetes patients review rxr full agonists rxr antagonists rxr modulators partial agonists reported anti diabetic effects discuss potential suitability antidiabetic agents
aggressive cell leukemia ankl exceedingly rare form leukemia carries poor prognosis median survival months using center international blood marrow transplant research database evaluated outcomes allogeneic hematopoietic cell transplantation allohct patients ankl twenty one patients centrally confirmed diagnosis ankl included median patient age years patients caucasian fourteen patients complete remission time allohct patients active disease median follow survivors months range year estimates nonrelapse mortality relapse progression progression free pfs overall survival respectively year pfs patients time allohct significantly better patients active disease transplantation versus year similar order versus conclusion registry analysis included majority non asian patient population shows allohct provide durable disease control subset ankl patients achieving transplantation appears prerequisite successful transplantation outcomes american society blood marrow transplantation
hybrid electrical vehicles involve two sources energy usually gasoline electricity energy management determines power sharing internal combustion engine electrical machine highly dependent driving cycle use vehicle context optimal sizing determined driving cycle power train characteristics ratios physical limitations maximum torque available energy management key idea work involve driving cycle environment electrical machine global multi objective optimization process taking account optimal energy management accurate model based magnetic circuit equivalent model
mycosis fungoides common form cutaneous cell lymphoma although indolent early stages aggressive advanced stages particularly large cell transformation occurs histologically transformed similar primary cutaneous anaplastic large cell lymphoma pcalcl nodal alcl nalcl associated immunohistochemical expression anaplastic lymphoma kinase alk previously reported case documenting presence alk immunohistochemistry patient stage concurrent nalcl unique finding due fact alk positivity usually found nalcl goal study examine extent alk may expressed different morphologic lesions one hundred three biopsies patients including patient original case confirmed representing various lesion stages subtypes tested alk immunohistochemical staining biopsies original index case stage concurrent nalcl expressed alk results conclude alk routinely present lesion stage variant type routine staining alk therefore additional benefit workup known early stage however use may beneficial initial workup unspecified large cell lymphomas skin
background patellofemoral cartilage deterioration osteoarthritis reported associated recurrent patellar dislocation however association first time traumatic patellar dislocation cartilage deterioration unknown purpose aim study assess long term cartilage deterioration patellofemoral tibiofemoral joint conservatively treated traumatic lateral patellar dislocation study design case series level evidence methods twenty patients mean age years sustained first time traumatic lateral patellar dislocation previous patellofemoral instability symptoms initially scanned magnetic resonance imaging mri follow mri conducted average years first time lateral patellar dislocation subjective instability symptoms knee injury osteoarthritis outcome score also assessed results primary mri patellofemoral cartilage injury seen patients injuries seen patellar cartilage especially medial facet follow mri patellofemoral cartilage deterioration visible patients central patella seemed especially prone cartilage deterioration follow half patients grade cartilage lesions patellofemoral joint follow mri primary mri patient exhibited tibiofemoral joint cartilage lesions whereas time follow patients exhibited tibiofemoral cartilage lesions majority lesions considered clinically nonsignificant international cartilage repair society seen lateral compartment patients injury patellar cartilage reported subsequent instability patellofemoral joint associated significant cartilage deterioration follow mri compared patients without redislocation conclusion recurrent lateral patellar dislocation known lead degenerative process single first time infrequently recurring traumatic lateral patellar dislocation also seems associated gradual cartilage deterioration traumatic lateral patellar dislocation might initiate gradual degeneration cartilage patellofemoral joint lead development generalized knee osteoarthritis instability symptoms patellofemoral joint however related severity deterioration
objective determine longitudinal associations patterns comorbid cigarette alcohol marijuana use antisocial personality disorder aspd major depressive episode mde generalized anxiety disorder gad adulthood method random community based sample bar age children adults community study going investigation substance use psychiatric disorders data collected six time waves conjoint trajectories cigarette alcohol marijuana use spanning adolescence adulthood determined multivariable logistic regression analyses assessed associations trajectory group membership aspd mde gad adulthood results five conjoint trajectory groups obtained hhh chronic cigarette alcohol marijuana use ddd delayed late starting cigarette alcohol marijuana use lml low smoking moderate alcohol use occasional marijuana use hmn chronic smoking moderate alcohol use marijuana use non occasional alcohol use compared members non group hhh group significantly greater odds aspd adjusted odds ratio aor confidence interval mde aor gad aor members ddd lml hmn groups weaker less consistent associations three psychiatric outcomes conclusions large community based sample long term concurrent use one substance associated externalizing internalizing psychiatric disorders adulthood prevention treatment programs might target individuals community general clinical populations comorbid substance use even identified substance use disorder elsevier ltd rights reserved
context amitriptyline tricyclic antidepressant used management psychological disorders various types pain previous work founded amitriptyline inhibited migration polymorphonuclear pmn site inflammation aims evaluate effect amitriptyline expression inflammatory mediators intercellular adhesion molecule icam vascular cell adhesion molecule vcam cyclooxygenase cox inducible nitric oxide synthase inos methods vitro model system lps stimulated human endothelial cells macrophages also vivo model carrageenan induced paw edema rat used expression inflammatory mediator genes determined qrt real time pcr endothelial cells soluble forms icam vcam quantified elisa results expression icam vcam cox inos sicam svcam significantly decreased amitriptyline finding study also confirmed intraperitoneal injection amitriptyline inhibited carrageenan induced inflammation rat paw edema conclusions results present study provide evidence anti inflammatory effect amitriptyline effect appears mediated regulation inflammatory genes
children histories maltreatment disruptions care elevated risk impairments early language development contribute difficulties developmental domains across childhood given research demonstrating associations parent responsiveness children early language development examined whether parenting intervention administered infancy improved preschool receptive language skills children involved child welfare system attachment biobehavioral catch abc session intervention aims enhance parent child interactions follow results randomized clinical trial demonstrated infants received abc intervention scored significantly higher test receptive vocabulary age months infants received control intervention results provide evidence critical role parental responsiveness supporting optimal language development among young children histories child welfare involvement
background dementia syndrome regarded clinical diagnosis focus supplemental biomarkers increasing automatic magnetic resonance imaging mri volumetry method neuroquant developed use clinical settings purpose evaluate clinical usefulness distinguishing alzheimer disease dementia nondementia non dementia material methods performed patients diagnosed according criteria icd vascular dementia parkinson disease dementia pdd winblad criteria mild cognitive impairment lundmanchester criteria frontotemporal dementia revised consensus criteria lewy body dementia lbd receiver operating curve roc analyses calculation area curve auc regression analyses carried results forebrain parenchyma auc hippocampus auc inferior lateral ventricles auc yielded highest aucs non dementia discrimination hippocampus auc cerebellum auc separated non dementia cerebellum separated pdd lbd auc separate multiple regression analyses adjusted age gender showed memory cerad word delayed recall beta strongly associated hippocampus volume diagnostic distinction versus nondementia beta conclusion measures could separate non dementia fairly well generally poorer non dementia degree memory impairment age gender diagnostic distinction associated hippocampus volume adjusted analyses surprisingly cerebellum found relevant separating pdd lbd
subtle relationship feeling thinking affect cognition fascinated philosophers writers since time immemorial yet empirical research topic relatively neglected psychologists recently many claims emphasising beneficial cognitive behavioural consequences positive affect many recent works suggest negative affect may also facilitate optimal performance many situations consistent evolutionary theories suggesting adaptive signalling function various affective states paper reviews traditional current psychological theories linking affect social thinking behaviour variety empirical studies laboratory also presented demonstrating many situations negative affect promotes optimal performance cognitive social tasks including tasks memory social judgements motivation strategic interpersonal behaviours results interpreted terms dual process theory predicts negative affect promotes accommodative vigilant externally focused thinking strategy relevance findings recent affect cognition theories discussed practical implications negative affect promoting improved social thinking performance number applied fields considered
assessment spondyloarthritis international society health index asas inclusive questionnaire able describe total impairments restrictions due axial spondyloarthritis axspa considering relationship asas ankylosing spondylitis disease activity score asdas crp aim study establish asas cut values functioning categories employing asdas crp disease activity states axspa patients asas asdas cpr obtained consecutive axspa patients divided four asdas crp disease activity categories high high disease activity considered together asas cut offs obtained arithmetic mean rounded closest whole number percentile mean value lower rank percentile mean value adjacent higher rank approach applied transition inactive disease moderate disease activity transition moderate disease activity high high disease activity twenty three patients classified inactive disease classified moderate disease activity high high disease activity state using approach percentile mean values adjacent disease activity states asas cut offs resulted dinstinguish normal functioning distinguish moderate impairment functioning distinguish severe impairment functioning asas seems reliable tool define functioning categories patients axspa
prevalence autism spectrum disorders asd suggest one children affected convincing evidence parenting child asd associated elevated distress mental health problems researchers begun investigate treatments directly target parents psychological well conducted narrative review studies empirically tested effects interventions targeting improvements mental health parents children asd following range search strategies total studies seven randomized controlled trials rcts six pre post test designs met inclusion criteria calculated reported effect sizes rcts average treatment produced medium large effect sizes improvements parenting stress general health reductions depression anxiety interventions appeared promising included stress management relaxation techniques expressive writing mindfulness based stress reduction acceptance commitment therapy however one study conducted follow assessment months post intervention study populations primarily consisted english speaking mothers ages years conclusions limited small sample sizes homogeneity sample population reliance self report therefore body research contains significant limitations need improvement field move forward benefit sizable number parents elsevier ltd rights reserved
background human immunodeficiency virus hiv pandemic exacerbated tuberculosis disease especially sub saharan african countries world health organization joint united nations program hiv aids unaids recommended isoniazid preventive therapy ipt hiv infected patients reduce burden tuberculosis ethiopia implementing ipt since however effectiveness ipt averting occurrence active tuberculosis among hiv infected patients assessed methods retrospective cohort study employed using secondary data public health institutions addis ababa descriptive statistics generalized linear model based poisson regression used data analysis results hiv infected patients followed person years total incident tuberculosis cases occurred incidence rate person year person year person year among ipt completed completed non exposed patients respectively adjusted incidence rate ratio airr among ipt completed non exposed patients gender residence area employment status baseline stage disease aids level counts identified risk factors incidence airr among patients took highly active anti retroviral therapy haart ipt compared took haart alone ipt significantly reduced occurrence active years conclusions ipt significantly reduced tuberculosis incidence compared ipt non exposed patients moreover concomitant use haart ipt shown significant reduction tuberculosis incidence use haart alone since ipt significantly protected occurrence active years implementation strengthened country
performance discontinuous deformation analysis dda needs improved large scale analysis study contact detection open close iteration bottlenecks dda computing reimplemented graphics processing units gpus contact detection proposed parallel method accelerates dda computing maintaining high loading balance data reuse ratio gpu open close iteration divided two parts simultaneous equations solver interpenetration checker simultaneous equations solver parallel jacobi method block jacobi preconditioned conjugate gradient bjpcg methods implemented gpu substitute original successive overrelaxation sor method parallel interpenetration checker improved optimizing conditional branches gpu two applications new parallel methods introduced results showed broad narrow phases contact detection showed times speedup respectively parallel bjpcg simultaneous equations solver showed times speedup parallel interpenetration checker showed times speedup total performance dda improved times respectively using proposed methods american society civil engineers
objective identify potential risk factors associated rehospitalization among medicare recipients heart failure receiving telehomecare materials methods study nonexperimental cross sectional secondary data analysis centers medicare medicaid cms mandated assessment called outcome assessment information set oasis provided large home care company total patients received telehomecare january august included analyses used multiple logistic regression results overall rate rehospitalization patients receiving telehomecare moderately frail health status presence severe pain presence dermatologic problems independence dressing one lower body compared slightly dependent mostly dependent patient groups identified risk factors rehospitalization conclusions risk factors identified study may used drive effective telehomecare placements referrals additional services among telehomecare patients
household economic strengthening hes programs increase welfare households children decrease cyclical poverty yet research shows hes programs positive household outcomes often fail produce corresponding improvements children lives depth interviews idis households part hes program liberia provide window intra household decision making affecting children health education two general themes examined decision making household assets including cash agriculture food decision making around children nutrition health education findings indicate children priority household spending concentrated areas directly linked child well however specific knowledge gaps identified may hindered improvements appropriate nutrition child development basic financial planning increase savings results also show decision making balanced men women identifies need address knowledge gaps among men women produce greater impacts recommendations illustrate greater understanding intra household decision making used program design develop complementary programming messages maximize benefit hes programs children well
background aims vascular plants important questions regarding phloem function remain unanswered due problems invasive experimental procedures highly sensitive tissue certain brown algae kelps laminariales also possess sieve tubes photoassimilate transport embedded large volumes gelatinous extracellular matrix isolates neighbouring cells therefore hypothesized kelp sieve tubes might tolerate invasive experimentation better analogues higher plants sought establish nereocystis luetkeana experimental system methods predominant localization cellulose gelatinous extracellular matrix luetkeana verified using specific fluorescent markers confocal laser scanning microscopy sieve tubes intact specimens loaded fluorescent dyes either passively carboxyfluorescein diacetate cfda microinjection rhodamine movement dyes monitored fluorescence microscopy key results application cfda demonstrated source sink bulk flow luetkeana sieve tubes revealed complexity sieve tube structure branches junctions lateral connections microinjection sieve elements proved comparatively easy pulsed rhodamine injection enabled determination flow velocity individual sieve elements direct visualization pressure induced reversals flow direction across sieve plates conclusions reversal flow direction across sieve plates pressurizing downstream sieve element conclusively demonstrates critical requirement munch theory satisfied kelp evidence exists tracheophytes high tolerance sieve elements experimental manipulation luetkeana promising alternative vascular plants studying fluid mechanics sieve tube networks
united states federally funded health plans mandated measure quality care adherence based medication quality metrics depend completeness administrative claims data accurate measurement low cost generic programs lcgps cause medications fills missing claims data medications adjudicated patient insurance study sought assess magnitude impact lcgps quality measures data medical expenditure panel survey meps used medication fills select medication classes classified lcgp fills individuals classified never sometimes always users lcgps individuals classified based insurance type private medicare medicaid dual eligible proportion days covered pdc calculated medication class proportion users pdc reported observed metric would calculated based claims data true metric included missing medication fills due lcgps true measures adherence higher observed measures effect magnitude highest private insurance medication classes utilized often lcgps thus medication based quality measures may underestimated due lcgps
clinical delineation epilepsy migraine cause visual auras may difficult many cases lead misdiagnosis overview differentiating features concerning auras presented furthermore discuss characteristics children idiopathic focal occipital lobe epilepsies types gastaut panayiotopoulos interictal periictal headache adults epilepsy
manufacturing engineering localization accuracy key concern design fixture specify locating scheme tolerance allocation paper presents general analysis methodology able characterize effects localization source errors based position orientation workpiece methodology fixture model formulated taking account overall errors among system consisting workpiece fixture design fixture locating scheme model locating principle criterion robust optimal design proposed improve localization quality fixture examples provided allow detailed discussion carry optimal design locating scheme comparative study also made optimal solution empirical one finally experiment made validate fixture locating scheme cylindrical workpiece conclude robust design method effectively achieves stable machining precision workpieces
retrospective study done assess prevalence congenital hypothyroidism among children born arar city kingdom saudi arabia years data collected newborns registry central hospital prevalence congenital hypothyroidism per live births gender difference
background aim although known metformin reduce risk colorectal cancer unclear whether protects colorectal adenoma methods study conducted systematic literature search medline embase cochrane library using primary keywords colorectal colon rectal rectum adenoma polyp neoplasia neoplasm metformin diabetes studies included evaluated association metformin use colorectal adenoma reported odds ratios ors provided data could estimated results ten studies total patients evaluated across studies median range patients taking metformin also adenoma median range taking metformin adenoma meta analysis metformin use reduced risk adenoma pooled confidence interval upon subgroup analyses metformin use tended reduce risk adenoma high risk population consisting patients history colorectal neoplasia crn pooled addition metformin reduced risk adenoma high risk population consisting patients diabetes mellitus pooled conclusion metformin use seemed associated reduced risk colorectal adenoma especially high risk populations consisting patients diabetes mellitus history crn although statistical power achieved patients history crn
disruption crucial balance regulatory cells tregs cells recently implicated various autoimmune disorders tregs responsible maintenance self tolerance thus inhibiting autoimmunity whereas pro inflammatory cells contribute induction propagation inflammation distortion treg balance favoring pro inflammatory side hence suspected contribute exacerbation autoimmune disorders review aims summarize recent data advances targeted therapeutic modification treg balance well information efficacy candidate therapeutics respect treatment autoimmune diseases
study aimed identification proteomics validation enzyme linked immunosorbent assay elisa potential urinary biomarkers lupus nephritis study subjects comprised systemic lupus erythematosus sle patients controls rheumatoid arthritis diabetes mellitus healthy individuals based sle disease activity index sledai patients classified active renal active non renal anr inactive disease urinary proteins group patients resolved two dimensional gel electrophoresis identified matrix assisted laser desorption ionization time flight mass spectrometry maldi tof selected biomarkers validated elisa using samples patients controls patients followed months start therapy three urinary proteins alpha anti chymotrypsin act haptoglobin hap retinol binding protein rbp detected patients upon validation act levels higher patients groups showed good correlation renal sledai well sledai fold higher groups correlated well renal sledai sledai rbp levels also higher patients groups except diabetes showed moderate correlation renal sledai sledai upon follow treatment levels three proteins declined months multiple logistic regression identified act best marker differentiate anr urinary hap act rbp potential biomarkers lupus nephritis activity
methylisothiazolinone mit widely used biocide hair skin care products high concentrations cooling towers paper mill refinery industry product recognized potent contact allergen discharged wastewater treatment plants wwtp industrial processes domestic usages however role mit biological treatment characterized therefore effect mit composition performance activated sludge analyzed purpose sequential batch reactor fed synthetic solution containing mit addition mit shown significant effect organic matter metabolization dissolved organic carbon doc removal remained constant contrary loss efficiency nitrification process occurred ammonium removal decreased per cycle throughout experiment first affecting nitrite oxidizing bacteria around cycles also ammonium oxidizing bacteria disappeared shown fluorescence situ hybridization analysis bioindicative studies based counts protozoa sludge biotic index indicated end process stable well colonized protozoa community obtained finally respirometric tests indicated acclimatization heterotrophic bacteria mit shown shorter lag periods sludge previously fed mit role mit biological treatment characterized increase knowledge pollutant effects activated sludge improve wwtp performance
microscope vision system retrieve small metallic surface via micro laser line scanning genetic algorithms presented technique laser line projected metallic surface laser diode head placed small distance away target micro laser line captured ccd camera attached microscope surface topography computed triangulation means line position microscope vision parameters calibration microscope vision system carried adaptive genetic algorithm based line position algorithm objective function constructed microscope geometry determine microscope vision parameters also genetic algorithm provides search space calculate microscope vision parameters high accuracy fast form procedure avoids errors produced missing references physical measurements employed traditional microscope vision systems contribution proposed system corroborated evaluation via accuracy speed traditional microscope vision systems retrieve micro scale surface topography
multidimensional treatment foster care preschoolers mtfc thus far tested diminishing behavior problems study tested relative efficacy mtfc multiple outcomes treatment usual netherlands tau study regular foster care study sample included children received mtfc children received tau children regular foster care rfc changes behavioral relationship functioning trauma symptoms hypothalamic adrenal pituitary hpa axis functioning caregiving stress assessed via questionnaires interviews salivary cortisol outcomes study evaluated using randomized controlled design quasi experimental design outcomes study according non equivalent group comparison evidence found relative efficacy mtfc tau treatment effect found trauma symptoms favor tau outcomes study revealed whereas caregiving stress secure base distortions significantly severe baseline mtfc compared rfc post treatment differences longer significant however percentages symptoms disinhibited attachment attachment disorder nearly equal groups baseline post treatment percentages indicated significantly symptoms mtfc addition results revealed significant difference severity externalizing problems post treatment favor rfc results obtained within study indicate children mtfc usual treatment foster care dutch context improved similarly thus showing advantages mtfc demonstrated results interpreted caution due lower planned power findings underscore challenges testing novel treatments across contexts highly different child welfare provisions
paper describes algorithmic construction kovanics basic expectedness distribution formulas technique computation gnostical scale parameter help matlab parallel computing toolbox properties distributions derivatives demonstrated also graphical figuration references applications data health environment introduced
background chronic lateral ankle instability occurs people acute ankle sprain initial treatment conservative fails ligament laxity present surgical intervention considered objectives compare different treatments conservative surgical chronic lateral ankle instability search strategy searched cochrane bone joint muscle trauma group specialised register cochrane central register controlled trials medline embase cinahl reference lists articles february selection criteria identified randomised quasi randomised controlled trials interventions chronic lateral ankle instability included data collection analysis two review authors independently assessed risk bias extracted data study appropriate results comparable studies pooled main results ten randomised controlled trials included limitations design conduct reporting trials resulted unclear high risk bias assessments relating allocation concealment assessor blinding incomplete selective outcome reporting limited pooling data possible neuromuscular training basis conservative treatment evaluated four trials neuromuscular training compared training resulted better ankle function scores end four weeks training ankle joint functional assessment tool ajfat mean difference trial participants foot ankle disability index fadi data trials participants fourth trial participants found significant difference functional outcome six weeks training programme cyclo ergometer directional compared traditional uni directional pedal longer term follow data available four trials four studies compared surgical procedures chronic ankle instability one trial participants found nerve injuries tenodesis anatomical reconstruction risk ratio one trial participants comparing dynamic versus static tenodesis excluded patients allocated dynamic tenodesis tendons thin trial found dynamic tenodesis resulted higher numbers people unsatisfactory function participants one trial comparing techniques lateral ankle ligament reconstruction participants found operating time shorter using reinsertion technique imbrication method minutes two trials participants compared functional mobilisation immobilisation surgery found early mobilisation led earlier return work weeks trial sports weeks trial authors conclusions neuromuscular training alone appears effective short term whether advantage would persist longer term follow known insufficient evidence support one surgical intervention another surgical intervention chronic ankle instability likely limitations use dynamic tenodesis surgical reconstruction early functional rehabilitation appears superior six weeks immobilisation restoring early function
mindfulness increasingly used weight management however strength evidence approach unclear although mindfulness based weight management programs success difficult conclude mindfulness components responsible research area complicated fact term mindfulness used refer range different practices additionally little understanding mechanisms mindfulness might exert effects review addresses issues examining research looked independent effects mindfulness mindfulness related strategies weight loss weight management related eating behaviors well looking evidence effects review also considers whether effects may vary different types strategy kinds mechanisms may responsible change concluded evidence support effects present moment awareness applied sensory properties food decentering however research areas yet examined controlled manner relation weight management crown copyright published elsevier ltd rights reserved
measurement system developed using micro distance imaging technology measure droplet sizes field legible droplet images acquired single lens reflex camera micro distance lens illumination source proper parameters droplets extracted effectively based background subtraction region growing repair shape factor screening concave points matching methods droplet characterizations including projective area diameter volume calculated using matlab image processing technology system displayed droplet sizes distribution regulation graphs convenient obtaining experimental regulation indoor comparison experiments developed system oil disk method conducted average relative errors respectively field comparison experiments revealed relative error developed system oil disk method developed system laser instrument method application experiments field conducted result revealed fine droplets better penetration coarse droplets tree canopy system simple structure lower cost compared instruments reduced experimental time compared image processing methods use oil disks good prospect use elsevier ltd rights reserved
objectives maternal nutrition pregnancy plays important role predisposing offspring development chronic disease adulthood including osteoporosis aim investigate maternal dietary intakes pregnancy focus nutrients important skeletal development offspring methods case control study cases pregnant women recruited vitamin pregnancy study age years controls non pregnant peers participating geelong osteoporosis study age years dietary intakes nutrients quantified using validated food frequency questionnaire results compared controls cases consumed energy median interquartile range day median intakes cases greater carbohydrates day fat day potassium day calcium day however pregnant women consuming greater amounts nutrients increased demand protein magnesium phosphorus zinc similarly translated likelihood achieving national recommendations corresponding nutrients conclusions practice compared non pregnant peers pregnant women likely meet dietary recommendations calcium potassium however pattern observed protein magnesium zinc future public health messages perhaps focus increasing awareness importance nutrients pregnancy
article examines support cultural preservation predictor support censorship entertainment media three arab gulf countries saudi arabia qatar united arab emirates country greater support cultural preservation positively associated support censorship belief done preserve cultural traditions qatar united arab emirates desire entertainment reflects one culture history saudi arabia united arab emirates positively associated support censorship two three countries belief hollywood films harmful morality variable associated stronger censorship support countries
noting general military regulations gmr contain numerous references aspects nonverbal behavior expressed prescribed behavior considered necessary new reading gmr nonverbal communication handbooks new reading possible reveals important aspects regard opportunities education adequate training agreement good knowledge field communication sciences paper aims setting prescriptive nonverbal profile romanian soldiers relation behavioral requirements resulting current gmr romanian armed forces research method consists documents analysis comprises placement four general normative documents different context communicative one identification explicit implicit nonverbal communication prescriptions included body normative texts analysis nonverbal prescription relationship major classes nonverbal behavior configuration nonverbal profile romanian soldiers based gmr behavioral prescriptions respect paper similar projective normative documents regulations memoranda etc developed institutions army research institute behavioral social sciences committee opportunities basic behavioral social sciences research army katz blascovitch hartel yager etc designed identify role nonverbal communication military context especially context intercultural actions different theaters operations following study intend focus future research field nonverbal communication romanian military context order subsequently build first necessary instrument development nonverbal communicative competence within romanian armed forces
non negative matrix factorization nmf effective method high dimensional data analysis widely used computer vision capture underlying structure image low dimensional space using parts based representations however nonnegative entries usually required data matrix nmf limits application besides actually unsupervised method without making use prior information data paper propose novel method called pairwise constrained graph regularized convex nonnegative matrix factorization pgcnmf allows processing mixed sign data matrix also incorporates pairwise constraints generated among labeled data convex nmf framework expect images class label similar representations low dimensional space much possible images different class labels dissimilar representations much possible clustering experiments nonnegative mixed sign real world image datasets conducted demonstrate effectiveness proposed method elsevier rights reserved
principal aims paper determine rate depreciation certified green conventional purpose built office pbo assess relationship building categories green building classifications toward influencing rental depreciation pbo buildings using cross sectional survey twenty seven buildings golden triangle area kuala lumpur data collected analysed using frequency descriptive statistics establish rate depreciation green conventional pbo buildings furthermore correlation regression techniques used assess significance building categories classifications influencing rental depreciation pbo buildings study successfully identifies average rate depreciation within dataset percent comparison average depreciation rate green office buildings conventional rate observed higher conventional class contrast green class pbo buildings results correlation analysis explain age building categories classifications strongly correlated rental depreciation lastly regression results evidenced building categories classifications significantly predict rental depreciation model authors published elsevier
basic computer programming one fundamental subjects students departments computer engineering computer science software engineering information technology computer business need learn subject students asked write programming code step step following textbook without understanding relationship among concepts example variables data types fundamental concepts array due reasons many students grasp fundamental concepts programming unable produce basic programs also unable learn understand complicated concepts future might better could find appropriate way improve conceptual learning ability topic therefore study personalized learning environment proposed basing upon multiple sources personalized information students namely learning problems learning styles performance levels diagnose students learning problems test answers analysed addition learning styles questionnaire employed adjusting presentation styles subject material based personalized learning style students performance levels classified high middle low used arrange learning material individual students well analyzing data students learned developed learning environment could develop understanding basic computer programming moreover positive attitude toward developed learning environment fit personalized learning authors published elsevier ltd selection peer review responsibility academic world education research center
background ptpn plays crucial role regulating function various cells immune system particularly cells polymorphisms ptpn gene associated many autoimmune diseases including type diabetes cell mediated disease objective present study aimed genotyping iranian population five polymorphisms ptpn gene methods study population consisted patients healthy controls genotyped five single nucleotide polymorphisms snps ptpn gene results regarding variant genotypes increased decreased patients compared controls respectively alleles snp found decreased increased patients respectively value however control groups differ genotype distribution allele frequency investigated snps conclusions ptpn minor allele associated iran accounting pathophysiology autoimmune diseases
improve understanding abnormalities non mendelian inheritance characteristics schizophrenia study examined dna methylation hydroxymethylation hmc schizophrenia associated gabrb gene encoding type gamma aminobutyric acid receptor beta subunit dnas peripheral white blood cells schizophrenic patients controls chinese han population examined reveal gabrb promoter level correlated olanzapine administration hmc level alu level correlated administration ziprasidone oxcarbazepine increased schizophrenic patients significant correlations promoter hmc levels genotypes single nucleotide polymorphisms snps observed snps schizophrenics heterozygous genotypes correlated increased hmc levels whereas heterozygous genotypes correlated decreased levels moreover gabrb promoter minor allele methylation disrupted type ccgg sites observed enhance promoter activity luciferase reporter transfected human embryonic kidney cells elevated gabrb mrna transcriptional level human neuroblastoma imr cells accompanied decreased promoter hmc levels induced azacytidine increased histone acetylation levels alu region induced valproic acid results reveal alterations gabrb genotype dependent methylation hydroxymethylation schizophrenia yielded transcriptional translational alterations cultured cells help elucidate genetic epigenetic interactions influencing schizophrenia elsevier ltd rights reserved
research recent years extensively investigated therapeutic efficacy mesenchymal stromal cells regenerative medicine many neurodegenerative diseases preclinical clinical stages however success rate stem cell therapy remains less translational phase lack relevant animal models potentially simulate molecular etiology human pathological symptoms might reason behind poor clinical outcomes associated stem cell therapy apparently self renewal differentiation ability mesenchymal stem cells may help study early developmental signaling pathways connected diseases alzheimer disease amyotrophic lateral sclerosis als etc vitro level cannabidiol non psychotrophic cannabinoid demonstrated potent anti inflammatory neuroprotective agent neurological preclinical models present study investigated modulatory role cannabidiol genes associated als using human gingiva derived mesenchymal stromal cells hgmscs vitro model system next generation transcriptomic sequencing analysis demonstrated considerable modifications expression genes connected als pathology oxidative stress mitochondrial dysfunction excitotoxicity hgmscs treated cannabidiol results suggest efficacy cannabidiol delineate unknown molecular pathways may underlie als pathology early stage using hgmscs compelling vitro system wiley periodicals inc
increased collagen expression tumors associated increased risk metastasis triple negative breast cancer tnbc highest propensity develop distant metastases evidence central fibrosis transforming growth factor beta tgf beta ligands regulated cancer associated fibroblasts cafs promote accumulation fibrosis cancer progression present study evaluated tnbc tumors enhanced collagen determine whether reduce metastasis targeting cafs pirfenidone pfd anti fibrotic agent well tgf beta antagonist patient derived xenograft models tnbc tumors exhibited accumulated collagen activated tgf beta signaling developed lung metastasis next primary cafs established tnbc homograft tumors tnbc xenograft tumors tumor specimens breast cancer patients cafs promoted primary tumor growth fibrosis tgf beta activation lung metastasis mouse model examined effects pfd vitro vivo found pfd inhibitory effects cell viability collagen production cafs culture furthermore cafs enhanced tumor growth pfd inhibited tumor growth induced cafs causing apoptosis culture assay tumor cells cafs vivo pfd alone inhibited tumor fibrosis tgf beta signaling inhibit tumor growth lung metastasis however pfd inhibited tumor growth lung metastasis synergistically combination doxorubicin thus pfd great potential novel clinically applicable tnbc therapy targets tumor stromal interaction
objective older persons hiv risk impaired cognition yet limited information modifiable factors associated neurocognitive function group design cross sectional observational study cognitive activities neurocognitive function methods examined relation frequency cognitive activity current neurocognitive performance older persons hiv african american men mean age mean education results linear regression models adjusted demographic variables found higher frequency cognitive activity associated better cognition global cognition semantic memory perceptual speed subsequent models examined role race demonstrated association significant among blacks global cognition episodic memory working memory perceptual speed interaction cognitive activity race estimate range conclusion greater frequency cognitive activity associated better neurocognitive function older persons hiv particularly older blacks longitudinal studies needed assess relation cognitive activity change neurocognitive function older persons hiv copyright wolters kluwer health inc rights reserved
introduction interleukin family cytokines emerged important pro inflammatory mediator psoriasis psoriatic arthritis psa ixekizumab ila inhibitor approved treatment chronic plaque psoriasis phase iii studies ixekizumab treating psa demonstrated promise minimizing disease severity progression areas covered review focuses biologic properties pharmacokinetics key clinical trial results demonstrated safety efficacy ixekizumab treating psoriatic disease expert commentary ixekizumab biologic approved treatment chronic plaque psoriasis respect safety ixekizumab generally well tolerated injection site reactions nasopharyngitis upper respiratory tract infections common adverse events patients anti drug antibodies low antibody titer levels resulting meaningful interference clinical response ixekizumab
work control strategy presented produce hydrogen demand feed internal combustion engine purpose modeling engine fueled gasoline blended anhydrous ethanol hydrogen additive developed considered hydrogen gas produced according engine demand hydrogen gas obtained alkaline electrolyzer gasoline ethanol blend added combustion chamber determined according stoichiometric ratio production hydrogen gas regulated proportional integral controller controller reference varying according mass flow air induced cylinder order ensure adequate production hydrogen gas operating condition engine main contribution work control scheme developed simulation order produce hydrogen demand operating point internal combustion engine fueled blend simulation results showed use hydrogen gas additive blend decreases fuel consumption average thermal efficiency increased approximately without brake power loss engine
scotland one several countries recently implemented new national curriculum highlight century educational priorities teachers mandated follow new curriculum guidelines known curriculum excellence cfe since fall purpose study use phenomenological lens investigate scottish secondary science teachers experiencing work curriculum development including daily lesson design broadly curriculum mapping within context reform remillard curriculum inquiry probed seven science teachers experiences create composite profile conscious thoughts curriculum design individual profiles highlight interactions curriculum mandates beliefs agentic orientations study indicated changes curriculum development required accepting new cognitive commitments including analyzing cfe document discern significant principles underlying change reflecting ways science teacher curriculum development problem solving endeavor iii undertaking complex processes curriculum mapping primary school way national qualification exams recognizing epistemological frame students science learning changed providing opportunities students create apply knowledge two significant findings include unpacking cognitive activities part transformation toward new epistemology pedagogy assertion official curriculum documents promote change albeit caveats concerning individual beliefs agentic orientations possibilities agency within school contexts wiley periodicals inc
calculate radiative properties sagittarius spectral energy distribution variability radio infrared images using first physically motivated black hole accretionmodels directly evolve electron thermodynamics general relativistic mhd simulations models reproduce coupled disc jet structure emission favoured previous phenomenological analytic numerical works specifically find low frequency radio emission dominated emission polar outflow emission ghz dominated inner region accretion disc latter produces time variable near infrared nir ray emission frequent flaring events including flares without corresponding ray flares flares weak ray flares photon ring clearly visible ghz encouraging future horizon scale observations also show anisotropic electron thermal conduction along magnetic field lines negligible effect radiative properties model conclude noting limitations current generation first principles models particularly outflow closer adiabatic isothermal thus underpredicts low frequency radio emission
thermal shock behavior ceramics cooling medium temperatures range degrees degrees studied detail measuring retained flexural strength water quenching test materials zro results show thermal shock resistance ceramics sensitive cooling medium temperature even low characterizing thermal shock resistance ceramics effect cooling medium temperature taken account higher water bath temperature may correspond greater thermal shock resistance ceramic materials owing effect thermal shock initial temperature material properties temperature difference thermal shock close critical temperature difference rupture little change cause great change retained strength materials retained strength materials sensitive temperature difference close critical temperature difference rupture unsuitable use critical temperature difference rupture characterize thermal shock resistance ceramic materials study shows innegligible problems evaluation system thermal shock resistance ceramic materials elsevier rights reserved
background objectivethe oral microbiome may help maintain systemic health including affects blood glucose levels however direct evidence linking oral microbiome diabetes lacking material methodswe compared oral microbiome profiles participants incident diabetes obese non diabetics normal weight non diabetics via deep sequencing rrna gene resultswe found phylum actinobacteria present significantly less abundant among patients diabetes among controls odds ratio confidence interval individuals relative abundance higher median value within phylum five families seven genera observed less abundant among patients diabetes notably genera actinomyces atopobium associated decreased risk diabetes values respectively stratified analyses race showed taxa phylum associated diabetes black white participants phylum also less abundant among non diabetic obese subjects compared normal weight individuals particularly genera mobiluncus corynebacterium bifidobacterium showed conclusionour study revealed multiple bacteria taxa phylum actinobacteria associated risk type diabetes also associated prevalence obesity suggesting oral microbiome may play important role diabetes etiology
inorganic photochromic materials attracted growing attention recent years reversible white purple photochromic powder material srgdli synthesized conventional solid state method surface color shows reversible white purple changes irradiated alternatively visible light thermal treat diffuse reflectance spectra used characterize photochromic properties including coloring bleaching results indicated optimal doping concentration found mol several cycles measurements including photo thermal induced bleaching indicates srgdli posses high fatigue resistance photochromism performance based thermoluminescence curves photochromism property related factors critical role traps motion charge carriers traps discussed finally schematic diagram illustrating photochromic mechanism proposed elsevier rights reserved
examined direct indirect paths involving receptive vocabulary diversity key consonants used communication dkcc improve understanding previously identified value added predictors associated later expressive vocabulary initially preverbal children autism spectrum disorder asd intentional communication dkcc parent linguistic responses accounted unique variance later expressive vocabulary controlling mid point receptive vocabulary responding joint attention confirm indirect paths mid point receptive vocabulary dkcc mediated association intentional communication expressive vocabulary research needed replicate findings test potentially causal relations provide specific sequence intervention targets preverbal children asd
conventional multilevel modeling works well purely hierarchical data however pure hierarchies rarely exist real datasets applied researchers employ hoc procedures create purely hierarchical data example applied educational researchers either delete mobile participants data analysis identify student last school attended including explanatory variable indicating whether student mobile simulation study compared parameter standard error estimates two hoc procedures handling assessing influence mobility outcomes results based use multiple membership random effects model substantial bias found parameters multiple membership data structures ignored
twin box girders popular choice among long span bridge engineers aerodynamic performance system critical stability bridge wind excitation two groups twin box girders six representative slot width ratios varying utilised investigate influence different wind fairing shapes aerodynamic instability performance torsional divergence flutter girders girders two wind fairing shapes various slot ratios investigated wind tunnel tests theoretical analyses based experimental results static wind loads critical flutter wind velocities symmetry wind fairing showed influence development pattern drag force coefficients flutter performance significantly affected slot width ratio also shown effect structural stiffness variation caused change slot width ratio neglected stationary torsional divergence analysis flutter performance twin box girders asymmetric wind fairing sensitive slot width ratio due existence optimal slot width opposite case symmetric wind fairing especially ratio different aerodynamic damping parts contributing torsional aerodynamic damping participation level degree freedom dof analysed two dimensional three degree freedom dof method results indicate improvement flutter performance mainly attributed decrease aerodynamic negative damping part caused couple effect torsional vertical motion increase participation level heaving motion flutter onset particle image velocimetry piv techniques employed reveal change central slot width ratio symmetry wind fairing great influence vortices characteristics especially central slot region slot ratio determined observing flow structures around deck sections terms wind velocity field vortex characteristics elsevier ltd rights reserved
early work call centers focused opinion collection service acceptance used manual entry record text information incoming calls count various types calls development text mining technologies possible call centers become information providers although traditional text mining methods well studied algorithm designed specifically call center data contains structured information call center addition plain text telephone call usually several properties caller number call time aiming data characteristics call centers paper propose improved latent dirichlet allocation lda model called lda includes information external related attributes suitable building topic mining models call centers present gibbs sampling distributed computing implementation model inferences use datasets china central television telephone call center perform experiment topic detection results show lda uses external correlation properties lower perplexity value better generalization performance traditional lda method find topics associated values contained external attributes copyright john wiley sons ltd
background imaging histology clear cell ependymoma cerebellum based hemangioblastoma similar distinguishing diagnostic challenge case presentation year old chinese woman presented intermittent headache years duration computed tomography magnetic resonance imaging revealed mass cerebellum neurological imaging suggested hemangioblastoma histologically tumor included cellular paucicellular areas cells arranged nests diffusely distributed highly vascular area tumor cells arranged clusters separated capillaries low magnification tumor mimicked cellular high magnification tumor cells showed clear cytoplasm instead vacuolated cytoplasm typically observed moreover spindly bipolar elements resembling tanycytes observed within nest structures although features indicated possibility ependymoma neither true ependymal rosettes ependymal lined profile observed tumor characterized prominent vascularity glomeruloid formation absent saw pleomorphism foci tumor giant cells pathologic mitosis palisaded necrosis absent tumor cells positive glial fibrillary acidic protein epithelial membrane antigen expressed paranuclear dot like ring like pattern index approximately considering patient symptom neurological imaging pathological findings diagnosed cerebellar ependymoma grade conclusions report case ependymoma overlapping clear cell tanycytic features review literature evaluate real incidence pathologists consider rare diagnosis confronted similar presentation
influence wetlands basin hydrology channel hydraulics investigated small canadian basin using mike nam model danish hydraulic institute dhi black creek basin area consists wetlands methodology involved long term continuous simulation basin without wetlands present analysis shows annual basis wetlands reduce total runoff less increase evapotranspiration amount overland flow decreases base flow increases due wetland presence groundwater recharge also increases individual runoff events wetlands reduce runoff terms peak volume respectively year flood current conditions would become year flood wetlands removed wetlands suppress snow melt generated flood peaks spring freshet summer floods wetlands also reduce water level spring freshet summer storms respectively channel flow water level velocity influenced wetlands rare flood events american society civil engineers
background immune mediated inflammatory diseases imids group complex prevalent diseases disease diagnostic activity monitoring highly challenging determination metabolite profiles biological samples becoming powerful approach identify new biomarkers clinical utility order identify new metabolite biomarkers diagnosis disease activity performed first large scale profiling urine metabolome six prevalent imids rheumatoid arthritis psoriatic arthritis psoriasis systemic lupus erythematosus crohn disease ulcerative colitis methods using nuclear magnetic resonance analyzed urine metabolome discovery cohort patients controls within imid two patient subgroups recruited representing extreme disease activity high low metabolite association analysis disease diagnosis disease activity performed using multivariate linear regression order control effects clinical epidemiological technical variability multiple test correction significant metabolite biomarkers validated independent cohort patients controls results discovery cohort identified significant associations urine metabolite levels disease diagnosis three significant metabolite associations disease activity fdr using validation cohort validated diagnostic associations three metabolite associations disease activity pfdr combining diagnostic biomarkers using multivariate classifiers obtained good disease prediction accuracy imids particularly high inflammatory bowel diseases several associated metabolites found commonly altered multiple imids considered hub biomarkers analysis metabolic reactions connecting imid associated metabolites showed overrepresentation citric acid cycle phenylalanine glycine serine metabolism pathways conclusions study shows urine source biomarkers clinical utility imids found imids show similar metabolic changes particularly clinically similar diseases found first time presence hub metabolites findings represent important step development efficient less invasive diagnostic disease monitoring methods imids
modularity benefits including independent maintenance comprehension individual modules widely advocated however empirical assessments investigate benefits mostly focused source code thus relevance modularity earlier artifacts still clear requirements design models paper use multimethod technique including designed experiments empirically evaluate benefits modularity context two approaches specifying product line use case scenarios pluss msvcm first uses annotative approach specifying variability whereas second relies aspect oriented constructs separating common variant scenario specifications evaluating approaches specifications several systems find msvcm reduces feature scattering improves scenario cohesion results suggest evolving product line specification using msvcm requires localized changes hand results six experiments reveal msvcm requires time derive product line specifications contrasting modularity results reduces time evolve product line specification subjects well trained used task evolving product line specifications
paper made combined analytical based force method classical strength materials experimental based strain gauges measurements analysis three dimensional metallic structure statically loaded
recession related increases men child care well documented supporting evidence describes last several decades century changes family life association families economic conditions macro economy provide reason question continued existence recession effect article evaluates frequency married cohabiting fathers engagement day day tasks child care called great recession using data male respondents national survey family growth results indicated increase men frequency engagement physical care feeding starting continuing share men engaged daily play fell sharply recession onset rebounded subsequent years results suggest even narrowing gendered division domestic labor room remains families respond flexibly economic shifts
epithelial mesenchymal transition emt implications tumor progression metastasis metabolic alterations described cancer development studies focused metabolic wiring takes place emt still limited performed metabolomics profiling breast epithelial cell line emt derived mesenchymal phenotype create genome scale metabolic models descriptive cell lines glycolysis oxphos higher epithelial phenotype amino acid anaplerosis fatty acid oxidation fueled mesenchymal phenotype comparative bioinformatics analysis ppar gamma ppar gamma found influential transcription factors associated metabolic wiring silico gene essentiality analysis predicts lat neutral amino acid transporter essential mesenchymal cell survival results define metabolic traits distinguish emt derived mesenchymal cell line epithelial progenitor may implications cancer progression metastasis furthermore tools presented aid identifying critical metabolic nodes may serve therapeutic targets aiming prevent emt inhibit metastatic dissemination author published elsevier ireland ltd
performance distribution board elevated temperature vital context reliable operation electrical network guidelines specifications available iec distribution board ambient temperature temperature range covers degrees degrees performance elevated temperature distribution board well known hence studies conducted subjecting distributing board rating temperature rise test elevated temperature degrees temperatures rise values monitored till thermal equilibrium distribution board obtained results obtained analyzed conjunction international standards studies revealed thermal performance distribution board exhibited higher temperature rise values studies results experimental arrangements presented present research work
purpose development secondary central nervous system involvement scns patients diffuse large cell lymphoma associated poor outcomes cns international prognostic index cns ipi proposed identifying patients greatest risk optimal model unknown methods retrospectively analysed patients diffuse large cell lymphoma diagnosed staged pet treated chop like regimens baseline clinicopathologic characteristics treatments outcome data collected clinical databases medical files evaluated association candidate prognostic factors modelled different risk models predicting scns results patients subsequently developed scns multivariate analysis disease stage iii elevated serum ldh kidney adrenal uterine testicular involvement independently associated scns strong correlation absolute number extranodal sites risk scns patients extranodal sites year cumulative incidence scns confidence interval compared among sites extranodal sites high risk disease according cns ipi considered baseline cns staging clinical risk prediction models suffer limited positive predictive ability highlighting need sensitive biomarkers identify patients highest risk devastating complication elsevier ltd rights reserved
wide bandgap semiconductors increasingly adopted enhance efficiency reduce volume power converters devices able switch dozens megahertz even megahertz lower power losses however high frequency operation may impose challenge digital control system required clock frequency gigahertz high precision applications difficult realize low cost microprocessors field programmable gate array fpga instead using hardware dependent high frequency clocks alternative solution utilize digital pulse width modulated dpwm dither techniques enhance dpwm resolution unfortunately achieved expense introducing low frequency harmonics may complicate output filter system controller design paper optimal dither technique proposed enhance resolution dpwm power converters concepts positive dither negative dither first proposed paper furthermore vector diagram based analysis indicates combination positive dithers negative dithers carefully selected dither sequence lowest order harmonics completely eliminated dither period multiples six switching periods cases proposed optimal dither technique produce minimized lowest order harmonics finally experimental results obtained synchronous buck converter validate feasibility proposed technique
differentiation small bowel tuberculosis sbtb crohn disease diagnostic challenge studied patients suspected sbtb terminal ileal involvement prospectively enrolled confirming patency gastrointestinal tract patients underwent capsule endoscopy final diagnosis found patients sbtb eight patients sbtb patients involvment ileocecal valve icv large aphthous ulcers ileal segment icv involvement seen five patients large aphthous ulcers observed seven patients respectively comparison patients sbtb increased frequency icv involvement lesser frequency aphthous ulcers help differentiating sbtb position involvement type ulcers present
voltage mode multiphase sinusoidal oscillator realized using second generation current conveyors grounded passive elements introduced paper proposed topology suitable realizing oscillators odd even number phases without modifying core topology non inverting current conveyors required construction oscillators topology benefit discrete component implementation point view behavior proposed topology evaluated experimental results cases three six phase oscillators elsevier gmbh rights reserved
introduction measuring functional inhibitor inh chromogenic elisa methods confirm diagnosis hereditary angioedema hae due inh deficiency previous studies found differences agreement assays objective evaluate agreement chromogenic elisa methods context observational study methods patients previously confirmed hae underwent functional inh testing patients contacted first degree relatives parents siblings offspring previously evaluated hae underwent panel complement testing including functional inh results overall patients hae untested relatives enrolled relatives newly diagnosed hae based laboratory results among patients previously confirmed hae low functional inh according chromogenic method whereas low equivocal normal functional inh according elisa method newly diagnosed relatives low functional inh according chromogenic method whereas low equivocal results according elisa method conclusion despite apparent discordance elisa chromogenic assays small number patients useful measuring functional inh establish diagnosis hae due inh deficiency functional inh results interpreted combination family clinical history complement tests american academy allergy asthma immunology
purpose purpose work adapt lightweight permanent magnet electron energy spectrometer measurement energy spectra therapeutic electron beams methods irradiation geometry measurement technique developed approximately permanent dipole magnet spectrometer produce suitable latent images computed radiography phosphor strips dual pinhole electron collimators created diameter approximately parallel beam incident spectrometer appropriate dose rate image plane strip location ray background latent image reduced thick lead block pinhole collimators removed using fitting technique theoretical energy dependent detector response functions drfs used iterative technique transform strip net mean dose profiles energy spectra central axis entrance spectrometer spectra transformed spectra source collimator distance scd correcting energy dependence electron scatter spectrometer calibrated comparing peak mean positions net mean dose profiles initially peak mean energies determined practical range central axis percent depth dose curves peak mean energies accounted collimation modified energy spectra recalibration utility spectrometer demonstrated measuring energy spectra seven electron beams mev elekta infinity radiotherapy accelerator results plots drf illustrated dependence energy position imaging plane approximately iterations solved energy spectra spectrometer entrance measured net mean dose profiles transforming spectra ones scd increased low energy tail spectra correspondingly decreasing peaks shifting slightly lower energies energy calibration plots peak mean energy versus peak mean position net mean dose profiles seven electron beams followed shape predicted lorentz force law uniform component magnetic field validating modeled uniform measured elekta energy spectra peak mean energies correlated mev mev spacings curves full width half maximum energy spectra decreased decreasing peak mean energy exception mev beam anomalously wide similarly decreased linearly peak mean energy exception mev beam attributed suboptimal tuning high power phase shifter recycled radiofrequency power reentering traveling wave accelerator conclusions apparatus analysis techniques authors demonstrated inexpensive lightweight permanent magnet electron energy spectrometer used measuring electron energy distributions therapeutic electron beams mev primary goal future work develop real time spectrometer incorporating real time imager potential applications beam matching ongoing beam tune maintenance measuring spectra input monte carlo beam calculations american association physicists medicine
two experiments looked role higher order list properties episodic recall probabilistic paired associate paradigm used cue repeatedly paired two different targets paradigm permitted cue target studied cue last list cue either two targets repeatedly paired cue although neither cue either two targets studied last list experiment higher order property whether targets given list animal names vegetable names experiment higher order property whether pairs list associatively related unrelated assumption participants using higher order properties retrieved target studied last list would also use properties recalling response cue studied lists recent list results supported use kinds higher order properties episodic access also showed higher order properties reinstated retrieving target used next memory access operation questions retrieval target would reinstate higher order list property different higher order list properties aid episodic access also discussed
content management systems cmss able let people technical skill manage websites rapidly create edit organize publish online contents example cmss often used establish commerce online shops community portals personal blogs organization websites thus cmss play role collecting data easily extended become intelligent internet systems popular cmss wordpress joomla rely relational databases sql databases mysql postgresql etc however due explosive growth huge data well structured characteristic sql databases may limit scalability handle horizontal scaling therefore regarding flexibility feasibility parallel processing cloud computing takes sql nosql databases consideration migrate original cms software sql databases nosql databases becomes one emerging critical research issue paper motivated propose autonomous sql nosql schema denormalization migration time paper also evaluates proposed mechanism realistic cms software based experimental results mechanism helps current cms software migrate cloud platform without designing database schemas also improves least access performance schema migration
kin altruism widely observed across species including humans however studies discussed development kin altruism relationship theory mind study year old children allocated resources kin friend stranger three allocation tasks allocation either incurred cost incurred cost conferred disadvantage results showed compared year olds year olds acted altruistically toward kin kin altruism uncorrelated theory mind findings suggest within context resource allocation kin altruism emerges toward end early childhood probably differs prosocial behavior relies solely understanding others perspectives elsevier inc rights reserved
performance determinism two critical metrics embedded systems real time requirements owing complexity current embedded systems along increased application demands real time operating systems rtoss become facto solution providing specific services system tasks however extra layer abstracts hardware software makes harder system achieve good performance determinism ease impact rtos system rtos run time services offloaded hardware layer paper presents hybrid rtos implementation several critical rtos services migrated software hardware improving system latency predictability special focus given rtos scheduler mutexes handling subsystem developed hardware accelerators synthesised field programmable gate array fpga exploiting point point fast simplex link fsl bus interconnect xilinx microbaze soft core processor approach shows hybrid rtos better performance predictability compared software version
context find best sequence refactorings applied software artifact optimization problem solved using search techniques field called search based refactoring sbr last years field gained importance many sbr approaches appeared arousing research interest objective objective paper provide overview existing sbr approaches presenting common characteristics identify trends research opportunities method systematic review conducted following plan includes definition research questions selection criteria search string selection search engines primary studies selected published last sixteen years classified considering dimensions related main sbr elements addressed artifacts encoding search technique used metrics available tools conducted evaluation results results show code addressed artifact evolutionary algorithms employed search technique furthermore times generated solution sequence refactorings respect refactorings considered usually ones fowler catalog trends opportunities future research include use models artifacts use many objectives study bad smells effect use hyper heuristics conclusions found many sbr approaches published recently approaches presented analyzed grouped following classification scheme paper contributes sbr field identify range possibilities serve basis motivate future researches elsevier rights reserved
scarce research explored sex partners provision social support impact depression among women purpose study examine role social support overall specific types support provided sex partner depressive symptoms among sample women assessed depression using centers epidemiological studies depression scale used social network inventory evaluate partner characteristics types support provided overall sample experienced depressive symptoms past days approximately one third sample partner provided emotional support financial support socialization support women said partner offered support partner gave three types support findings demonstrate partners level types support provided discounted mental health assessments
flower like pbs nip composites synthesized facile two step chemical route morphology structure resulting composites investigated sem tem images xrd spectra respectively results showed obtained composites composed cubic pbs flowers hexagonal nip nanoparticles nip nanoparticles coated surfaces flower like pbs microstructure found changing molar ratio flower like pbs nip composites successfully synthesized using cationic cetyltrimethylammonium bromide ctab anionic sodium dodecyl sulfate sds template furthermore using methylene blue model organic pollutant photocatalytic degradation experiments indicated prepared composites showed enhanced photocatalytic degradation activity methylene blue higher flower like pbs nip nanoparticles time work may expected find potential application water pollution treatment elsevier rights reserved
magnetorheological elastomers mre new type smart material overcome disadvantages magnetorheological fluid particle sedimentation instability mre smart material takes place conventional viscoelastic material creatively magnetic circuit analysis new viscoelastic damper adjustable stiffness proposed according scheme determined theoretical analysis viscoelastic damper adjustable stiffness designed whose maximum output force reaches performance experiment carried hydraulic loading device indicating new type damper continuously adjustable shear stiffness current change finally revised kelvin model established new type damper effectiveness model proved comparison model simulation results experimental results
study evaluated effectiveness standing strong together sst combined group based parent child intervention externalizing behavior year old children mild borderline intellectual disabilities mbid children externalizing behavior mbid cluster randomly assigned sst combined care usual care usual sst led significant benefit teacher reported parent reported externalizing behavior sst significant effects parent rated positive parenting parent child relationship present study shows multicomponent group based intervention children mbid feasible potential reduce children externalizing behavior improve parenting behavior parent child relationship
paper study design user selection time allocation uplink downlink transceiver processing matrix uplink downlink multi carrier transmission employing shared user equipment side distributed antenna system sudas proposed sudas simultaneously utilizes licensed frequency bands unlicensed frequency bands large available bandwidths millimeter wave bands enable spatial multiplexing gain single antenna ues improve energy efficiency throughput generation outdoor indoor communication resource allocation algorithm design formulated nonconvex optimization problem maximization end end system energy efficiency bits joule nonconvex matrix optimization problem converted equivalent nonconvex scalar optimization problem multiple parallel channels solved asymptotically globally optimal iterative algorithm besides propose suboptimal algorithm finds locally optimal solution nonconvex optimization problem simulation results illustrate proposed resource allocation algorithms sudas achieve significant performance gain terms system energy efficiency spectral efficiency compared conventional baseline systems offering multiple parallel data streams single antenna ues
mimotope mapping enables characterization allergen epitopes development diagnostic therapeutic approaches present study phage display peptide library used mimotope mapping based binding antibodies recombinant group allergen house dust mite dermatophagoides farinae der arthropod causes indoor allergies worldwide three monoclonal anti der antibodies used biopanning seven mimotopes identified common subsequence hsfw pskr tlv ast analyzed combination predicted discontinous epitopes amino acids identified key residues conformational epitopes der therefore seven mimotopes modification key amino acids may facilitate development blocking antibodies epitope specific immunotherapies mite allergy
congress passed legislation entitled medicare access chip children health insurance program reauthorization act macra led formation two reimbursement paradigms merit based incentive payment system mips alternative payment models apms macra effectively repealed centers medicare medicaid services cms sustainable growth rate sgr formula combining several cms quality reporting programs macra represents unparalleled acceleration toward reimbursement models recognize value rather volume first pathway mips consolidates several medicare quality reporting programs one composite score derived four performance categories including quality resource utilization meaningful use clinical practice improvement activities apm pathway includes following programs medicare accountable care organizations part medicare shared savings program bundled payments care improvement comprehensive primary care initiative existing apms yet determined eligible provide contextual framework healthcare legislation led formation current health policy offer recommendations regarding sgr orthopaedic surgeons may best steer reimbursement models
recent reports america infrastructure emphasized importance structural health monitoring civil infrastructures system identification key component many structural health monitoring strategies current system identification methods estimate models structure measuring displacements accelerations strains wired wireless sensors however methods typically involve installation limited number sensors discrete locations require additional data acquisition devices overcome limitations computer vision based techniques introduced recently employ high speed high resolution cameras cameras quite costly require tedious installation targets paper investigates potential using consumer grade cameras structural system identification without need install targets underlying methods target free displacement measurements introduced including region interest selection feature detection point tracking outlier removal set experiments conducted assess efficacy proposed approach comparing accuracy identified model one obtained using conventional wired system careful comparison results demonstrates significant potential proposed approach copyright john wiley sons ltd
design complex systems software architects deal tangle abstract artefacts measures ideas discover fitting underlying architecture common way structure complex systems terms interacting software components whose composition connections need properly adjusted along expected functionality non functional requirements key stage guide many design alternatives evaluated software architects appearance search based software engineering sbse brings approach supports software engineer along design process evolutionary algorithms applied deal abstract highly combinatorial optimisation problem architecture discovery multiple objective perspective definition resolution many objective optimisation problems currently becoming emerging challenge sbse application sophisticated techniques within evolutionary computation field needs considered paper diverse non functional requirements selected guide evolutionary search leading definition several optimisation problems metrics concerning architectural maintainability empirical study behaviour multi many objective evolutionary algorithms presented quality type returned solutions analysed discussed perspective evolutionary performance aspects interest expert results show many objective evolutionary algorithms provide useful mechanisms effectively explore design alternatives highly dimensional objective spaces
background aim child maltreatment abuse neglect significant problem worldwide cause impaired physical mental health throughout life true extent still remains unknown countries including turkey aim study apply two versions international society prevention child abuse neglect ispcan child abuse screening tool icast icast used assess child parent feedback compare reports given children given parents first study kind conducted turkey methods first icast translated turkish bilingual experts students parents asked complete icast icast respectively help trained researchers total data matched reports children parents obtained descriptive statistics used evaluate demographical variables chi square tests employed investigate statistical significance comparisons results present study demonstrated turkish parents consider rebukes insults corporal punishment effective ways disciplining children according parents reports use psychological abuse prevalent boys aged use physical abuse prevalent boys aged statistically significant relationship found parents economic conditions child abuse however relationship paternal educational background psychological abuse observed significant comparison children parents reports shows parents tended report child maltreatment conclusions results show significant healthcare problem turkey since child maltreatment prevalent parents generally aware extent possible approaches changing situation include efforts increase education levels promoting public awareness strengthening political commitments
abdominal pain one basic clinical presentations hereditary angioedema danazol common medicine used long years patients hereditary angioedema present two hereditary angioedema patients abdominal pain albeit danazol treatment whose final diagnoses colon carcinoma two consequences article shall insisted first patients hereditary angioedema differential diagnosis abdominal pain always important even though hereditary angioedema diagnosis exists second hardy speculated long term danazol treatment may cause different malignancies
agent based models abms increasingly used study population dynamics complex systems human immune system previously folcik basic immune simulator agent based model study interactions innate adaptive immunity theor biol med model developed basic immune simulator bis implemented using recursive porous agent simulation toolkit repast abm simulation framework however frameworks repast designed execute serially central processing units therefore efficiently handle large model sizes paper report implementation bis using flame gpu parallel computing abm simulator designed execute graphics processing units benchmark implementation simulate response immune system viral infection generic tissue cells compared results obtained original repast implementation statistical accuracy observe implementation performance advantage original repast implementation
objectives postpartum depression impacts women postpartum depression associated impaired bonding development marital discord suicide infanticide however current standard care screen women postpartum depression study modeled cost effectiveness physicians screening treating postpartum depression psychosis partnership psychiatrist methods study follows hypothetical cohort pregnant women experiencing one live birth year time horizon used decision tree model obtain outcomes screening treating postpartum depression psychosis using edinburgh postnatal depression scale use medicaid payer perspective cover approximately births cost effectiveness intervention measured cost per remission achieved cost per quality adjusted life year qaly gained conducted deterministic probabilistic sensitivity analyses results screening treating postpartum depression psychosis produced healthy women cost per woman incremental cost effectiveness ratios intervention branch compared usual care per qaly gained commonly accepted willingness pay threshold qaly gained per remission achieved results robust deterministic probabilistic sensitivity analyses input parameters conclusions practice screening treating postpartum depression cost effective intervention considered part usual postnatal care aligns recently proposed recommendations preventive services task force
internal combustion engine ice efficiently convert chemical energy mechanical energy majority energy dissipated heat exhaust coolant rather directly improving efficiency engine efforts made improve efficiency engine indirectly using waste heat recovery system two promising technologies found useful purpose thermoelectric generators tegs heat pipes tegs heat pipes solid state passive silent scalable durable use heat pipes potentially reduce thermal resistance pressure losses system well temperature regulation tegs increased design flexibility tegs limitations low temperature limits relatively low efficiency heat pipes limitations maximum rates heat transfer temperature limits used conjunction technologies potential create completely solid state passive waste heat recovery system authors published elsevier ltd
article describes ways music important part identity hence serves similar functions forms identity related communication language describe music used incite intergroup hatred among soccer fans military music support valued identities anthems etc relevant literature stereotyping including stereotyping groups related music included article also discusses music used reduce intergroup hostility via cross cultural musical collaboration contact article connects various literatures communication social psychology sociology ethnomusicology providing broad overview many connections communication music social identity closes research agenda interested studying intergroup communication music
objective prevalence impact low bone mineral density bmd psoriatic arthritis psa well understood aimed synthesize current evidence regarding prevalence impact risk factors low bmd fractures psa methods systematic literature search limited human studies conducted without language restriction data bmd prevalence osteoporosis osteopenia fractures risk factors morbidity mortality due low bmd psa patients collected result total studies case control cross sectional prospective cohort reviewed screening titles abstracts studies compared psa patients one control group four normal controls five psoriasis eight rheumatic diseases without healthy controls number psa patients studies ranged mean standard deviation age mean psa duration years reported prevalence osteoporosis varied low bmd identified significant problem studies age female sex postmenopausal status psa duration presence erosions cumulative steroid dose associated lower bmd fractures associated postmenopausal status axial disease studies reported hospitalization mortality due low bmd conclusion systematic review synthesizes current evidence bmd impact psa high likelihood bias inconsistent results suggest need well designed longitudinal studies bone health psa elsevier inc rights reserved
novel expert hydro aero static spindle design system strategy presented paper based comprehensive principles machine design machining dynamics metal cutting mechanics transmission lubrication types spindle decided selection system utilize dedicated logical choice algorithm light specifications workpiece material desired cutting condition hydro aero static spindles designed system dynamics perspective chatter vibration spindle automatically improved optimizing structural parameters spindle meanwhile predicted frequency response function frf spindle based rotor dynamics integrated chatter vibration stability law consequently expert design system enables structure machine tools designed efficiently higher precision proposed system demonstrated aerostatic spindle design micro array structures machining elsevier ltd rights reserved
study hypothesises educational leaflet psoriatic arthritis psa improve psoriasis patients attendance screening psa random sample patients years old coded diagnosis psoriasis diagnosis psa rheumatoid arthritis ankylosing spondylitis identified five surgeries yorkshire patients randomised receive study information alone educational leaflet invitation attend screening examination dermatologist rheumatologist nine hundred thirty two invitation packs sent recruit participants one hundred sixty nine current previous psoriasis previously undiagnosed psa estimated prevalence psa response rate lower expected significantly higher patients received educational leaflet response rates varied practice however deprivation scores practice revealed significant increase response leaflet deprivation decile significant differences practices educational leaflet psa improves attendance screening primary care practices higher levels socioeconomic deprivation
background addiction relies persistent alterations neuronal properties depends gene regulation activity regulated cytoskeleton associated protein arc immediate early gene modulates neuronal plasticity underlying learning memory role cocaine induced neuronal behavioral adaptations remains elusive methods acute cocaine treated mice used quantitative reverse transcriptase polymerase chain reaction immunocytochemistry confocal imaging striatum live imaging transfection assays arc overexpression performed primary cultures molecular behavioral adaptations cocaine studied arc deficient mice wild type littermates results arc messenger rna proteins rapidly induced striatum acute cocaine administration via extracellular signal regulated kinase dependent novo protein synthesis although detected dendrites arc accumulates nucleus active zones transcription colocalizes phospho ser histone important component nucleosomal response vitro arc overexpression downregulates phospho ser histone without modifying extracellular signal regulated kinase phosphorylation nucleus vivo arc deficient mice display decreased heterochromatin domains high rna polymerase activity enhanced cfos expression mice presented exacerbated psychomotor sensitization conditioned place preference induced low doses cocaine conclusions cocaine induces rapid induction arc nuclear accumulation striatal neurons locally alters nucleosomal response acts brake chromatin remodeling gene regulation original observations posit arc major homeostatic modulator molecular behavioral responses cocaine thus modulating arc levels may provide promising therapeutic approaches drug addiction
costs current genotyping methods limit application personalized therapy authors describe alternative approach detection single point polymorphisms using recombinant polymerase amplification allele specific technique use short chemically modified primers locked nucleic acids allowed selective isothermal amplification wild type mutant variants degrees within min amplification chip platform containing wells manufactured printer using thermoplastic polylactic acid platform reduces reagent consumption allows parallelization proof concept method applied genotyping four snps related treatment tobacco addiction target polymorphisms included comt gene oprm gene ankk gene chrna gene genotype populations well discriminated
potencies resorcinol propylthiouracil ptu methimazole mmi inducing developmental toxicity neurotoxicity compared pregnant rats regarded valid model human thyroid toxicity profound differences maternal thyroid hormone levels ths maternal toxicity well developmental neurotoxicity sequelae occurred resorcinol affected none end points ptu mmi caused significant effects therapy either ptu mmi first trimester human pregnancy cause reductions maternal ths accompanied disruptions prenatal development clinical mmi studies show sporadic evidence teratogenic effects equivocal relation thyroid peroxidase tpo inhibition recent decades mmi associated prenatal toxicity reported outcome possibly related carefully managed therapy orally administered resorcinol rapidly absorbed metabolized excreted undetectable thyroid contrast ptu mmi accumulated resorcinol potency inhibit tpo profoundly lower ptu mmi quantum chemical calculations may explain low resorcinol reactivity tpo thus distinctions target organ tpo inhibitory potency chemicals likely contributing different reductions maternal ths levels affecting potency cause developmental toxicity neurotoxicity published elsevier inc
substantial evidence social psychology documents traits predict behavior research behavioral economics establishes prior behavioral informationthe actual behavior another person pastinfluences future decision making suggestive role traits guiding future behavior agnostic specific psychological mechanism yet entire generalization process past behavior predicting future behavior fully explored additionally previous paradigms adequately dissociate prediction explanation provide participants trait information rely participants generate appropriate trait combine literature experimental approaches social psychology behavioral economics explore generalization process prior behavior guides future decisions across three studies utilizing consequential economic game paradigms online questionnaires initial group participants employees played time estimation game charity donations game second group participants employers viewed behavior first group decided whether invest employees trust game rock guessing game although participants infer trait warmth competence behavioral information first two games estimates normative behavior predicted investment decisions warmth relevant games better trait inferences results dissociate generalizations guided warmth competence behavioral information question extent traits always serve heuristics predict behavior copyright john wiley sons ltd
purpose purpose paper study multiphase bubbles flow motion vertical channel electroconducting liquid without influence magnetic field design methodology approach numerical calculations lattice boltzmann method lbm used based kinetic theory solving fluid mechanics physical problems phase field lattice boltzmann model developed simulate behaviour multiphase bubble bubble interaction rising fluid high density ratios findings behaviour rising bubble flow rectangular column two phases investigated two dimensional lbm originality value multiphase flow electroconducting liquids high ratio density studied using lbm
last decades wearable powered orthoses introduced state art lower limb rehabilitation applications driven electric motors comparing electric motor actuators pneumatic artificial muscle pam actuators compliant elasticity pams consequently safety comfort lower limb rehabilitation compliant robotic orthosis powered pams developed based safe control new control method proxy based sliding mode control psmc introduced rehabilitation robotics years ago combined safety accuracy tracking make suitable safe control pam actuators reason low frequency response pam actuators variable loads caused different human subjects fixed parameters psmc makes tracking performance vary subject subject lacks robustness paper presents modification psmc using neural network tune psmc gains online implements psmc modified psmc control schemes robotic orthosis experimental results demonstrate improved psmc method performs better tracking little degradation safety different loads human subjects
common diseases often show sex differences prevalence onset symptomology treatment prognosis although studies performed evaluate sex differences specific snp associations work aims comprehensively survey number complex heritable diseases anthropometric traits potential genetically encoded sex differences investigated include differential genetic liability thresholds distributions gene sex interaction autosomal loci major contribution chromosome gene environment interactions reflected genes responsive androgens estrogens finally tested overlap sex differential association anthropometric traits disease risk utilized complementary approaches assessing gwas association enrichment snp based heritability estimation explore explicit sex differences well enrichment sex implicated functional categories find consistent increased genetic load lower prevalence sex disproportionate role chromosome disease risk despite sex heterogeneity several traits find anthropometric traits show less complete correlation genetic contribution males females find convincing example autosome wide genome sex interaction multiple sclerosis also find evidence hormone responsive gene enrichment striking evidence contribution sex differential anthropometric associations common disease risk implying general mechanisms sexual dimorphism determining secondary sex characteristics shared effects disease risk
socioeconomic adversity targeted key upstream mechanism robust pathogenic effects maternal caregiving although research demonstrated negative repercussions socioeconomic difficulties little research documented potential mechanisms underlying association toward increasing understanding present study examined maternal working memory capacity inhibitory control may mediate associations socioeconomic risk change maternal sensitivity across free play discipline caregiving contexts study used longitudinal design utilized socioeconomically diverse sample mothers year old toddlers multi informants methods used assess constructs findings revealed maternal mediated associations socioeconomic risk parenting sensitivity specific effects working memory baseline sensitivity inhibitory control change sensitivity childrearing demands increased results interpreted within emerging conceptual frameworks regarding role parental neurocognitive functioning caregiving
evaluate ability different mri sequences detect chondrocalcinosis within knee cartilage menisci analyze association joint degeneration subjects radiographic knee chondrocalcinosis age years women selected osteoarthritis initiative matched controls without radiographic chondrocalcinosis visualization calcium containing crystals cac compared weighted gradient echo tge dual echo steady state dess intermediate weighted proton density weighted fast spin echo fse sequences obtained mri correlated semiquantitative cac score obtained radiographs structural abnormalities assessed using whole organ mri score worms logistic regression models used compare cartilage compartments without cac correlations cac counts mri sequences degree radiographic calcifications highest tge dess meniscus worms significantly higher subjects chondrocalcinosis compared controls cartilage defects significantly frequent compartments cac without patella lateral tibia lateral femur condyle gradient echo sequences useful detection chondrocalcinosis presence cac associated higher prevalence cartilage meniscal damage aeuro cent magnetic resonance imaging useful assessing burden calcium containing crystals cac aeuro cent gradient echo sequences superior fast spin echo sequences cac imaging aeuro cent presence cac associated meniscus cartilage degradation
background current analyses examined whether dysregulation profile could used identify children adolescents high risk complex serious psychopathology correlated emotional behavioral problems delinquent behavior suicide ideation assessed using child behavior checklist cbcl youth self report ysr residential care sample methods children adolescents aged years living residential care switzerland completed ysr professional caregivers completed cbcl participants meeting criteria score anxious depressed attention problems aggressive behavior scales ysr cbcl compared presence complex psychopathology defined presence emotional behavioral disorders also prevalence several psychiatric diagnoses suicidal ideation traumatic experiences delinquent behaviors problems related quality life results diagnostic criteria cbcl ysr met participants eight participants met criteria instruments analyses conducted separately cbcl ysr groups associated complex psychopathology cases according cbcl cases according ysr ysr somewhat likely associated psychiatric disorders associated problems cbcl limitations relatively small overlap cbcl ysr analyses conducted largely different samples likely contributing different results conclusions despite high rate psychopathology population studied ysr cbcl able detect small proportion complex psychiatric disorders result questions validity ysr cbcl detecting subjects complex serious psychopathology possible different screening instruments may effective elsevier rights reserved
cholesterol tocopherol essential lipophilic nutrients humans animals although cholesterol excess causes severe problems coronary heart disease necessary component cell membranes precursor biosynthesis steroid hormones bile acids niemann pick like npcl cholesterol transporter highly expressed small intestine liver humans plays important role cholesterol homeostasis cholesterol promotes npcl endocytosis early step cholesterol uptake furthermore alpha tocopherol active form vitamin sufficient amounts vitamin critical health reported npcl mediates alpha tocopherol absorption however mechanisms underlying process unknown study found treatment cells stably express npcl gfp alpha tocopherol promotes npcl endocytosis npcl inhibitor ezetimibe efficiently prevents alpha tocopherol induced endocytosis npcl cholesterol binding terminal domain ntd npcl npcl ntd essential npcl mediated cholesterol absorption found alpha tocopherol competitively binds npcl ntd cholesterol furthermore cells stably expressed npclantd gfp alpha tocopherol could induce endocytosis npclantd taken together results demonstrate npcl recognizes alpha tocopherol via ntd mediates alpha tocopherol uptake mechanism cholesterol absorption elsevier inc rights reserved
providing solutions current issues associated aging population become major challenge scientific community late adulthood social isolation issues frequent threatening independent living cognitive health elderly adults context ambient intelligence ami social networking sites snss promote independent living social integration improve health reduce chances developing cognitive decline ultimately prevent earlier death aim paper review literature ami sns technologies applied social integration elderly adults therefore systematic review conducted analyzed classified computational approaches address issues social isolation social integration elderly adults study revealed wide variety research works based ami sns technologies keep older adults socially active paper also identifies main technological resources strategies encourage social integration segment population concluded research field still emerging room significant contributions
crowds arise variety situations public concerts sporting matches typical conditions crowd moves orderly manner panic situations may lead catastrophic results propose computer vision method identify motion pattern changes human crowds related unusual event proposed approach identify global changes evaluating motion histograms time also local effects identifying clusters present similar spatial locations velocity vectors method tested publicly available data sets involving crowded scenarios synthetic data produced crowd simulation algorithm allows creation controlled environments known motion patterns particularly suitable multicamera scenarios
image processing technique using proper orthogonal decomposition pod infrared thermal data developed improve speed assessment heat source fields accompanying mechanical transformation method involved generation reduced orthonormal basis approximate thermal fields prior heat source estimation robustness method first assessed using penalising benchmark test test involved artificially setting several tricky situations arise practice high diffusivity low signal noise ratio complex heat source distribution etc application method several experimental temperature fields obtained infrared focal plane array camera presented error pod approximated solution terms heat sources reference solution computed via local least squares fitting method found negligible thus confirming efficiency advantages pod preprocessing technique method enabled obtain reliable estimate heat sources drastically reducing computation cost terms cpu time
background aims study describe compare performance illiterate low educated older adults without evidence cognitive impairment different versions boston naming test bnt original brazilian adapted abbreviated item even odd item cerad consortium establish registry alzheimer disease battery compare performance original versus adapted versions bnt methods total healthy older adults years older stratified according educational level years age years protocol comprised following instruments mini mental state examination mmse brief cognitive screening battery bcsb functional activities questionnaire faq geriatric depression scale gds bnt results illiterate participants poorer performance educated participants performance two educated groups similar versions bnt higher number correct responses observed adapted bnt original bnt three education groups conclusions adapted bnt appears suitable use low educated brazilian population present study provided normative data low educated elderly several different versions bnt may helpful diagnosing naming deficits among elderly strata population
main purpose study presentation skills evaluation pre service teachers via fuzzy logic two different groups study first one consists instructors serving computer education instructional technology ceit department firat university group supplied expert view ranking importance matters presentation evaluation scale pes forming rule base sets ground operation fuzzy logic mechanism second group consists juniors operating systems applications course ceit department students group make presentation associated units course pes applied study conducted data obtained scale frequencies percentages wilcoxon test used analyze data sets found significant difference pes obtained student scores scores passes fuzzy logic mechanism scores students decreased increased significant change elsevier ltd rights reserved
major challenge social networking services sns getting users exhibit prosocial behavior active participation creating sharing content seek integrate reconcile varying sometimes conflicting explanations prosocial behaviors sns rooted postadoption behavior commitment theory study offers three distinct mechanisms regulate one experience sns translates commitment leads prosocial behavior particular satisfaction affective commitment active participation substantiate dedication based mechanism past investments continuance commitment resulting inattention alternatives form constraint based mechanism social support normative commitment users intentions moderate comments third obligation based mechanism empirically tested tripartite model data collected actual facebook users results analysis supported proposed relationships mechanism experiential factor mediating type commitment prosocial outcome intermechanism effects rare commitment mediators outcomes common experiential antecedents commitment factors understanding mechanisms allows sns managers fine tune service experience promote specific prosocial behaviors meanwhile researchers benefit overarching view prosocial behavior sns helps combine contrast emergent perspectives theories
paper presents conceptual foundations software system solution modelling activity formally based two essential concepts artefact interface modelling activity envisions two objectives explicit emphasis interfaces importance software engineering preparation framework inside loop structure behaviour formalized considering inherent benefits modelling activity general modelling activity automation particular
paper deals semantic composition ubiquitous computing ubicomp services multi domain heterogeneous environments new semantic framework enabling specification multidomain composite services proving correctness proposed proposed framework reduces gap safety critical systems including ubiquitous services best effort engineering practices consists extensible semantic conceptual model scm ambient intelligence systems composition formal system based basic constructive description logics bcdl soundness property proof proposed formal system well services composition correctness proofs demonstrated along interactive theorem prover isabelle hol
studying brain abnormalities behavioral addiction including enables exclude possible confounding effects exposure neurotoxic substances provide important insight lead better understanding addiction per brain structural magnetic resonance imaging studies although results inconsistent hand suggested heterogeneous disorder terms risk attitude aimed examine heterogeneity combining behavioral economics task voxel based morphometry thirty six male patients healthy male control subjects underwent task estimation loss aversion assess risk attitude real life decision making patients divided two groups based level loss aversion low high groups showed common gray matter volume reduction left supramarginal gyrus bilateral posterior cerebellum high loss aversion showed pronounced reduction left posterior cerebellum additional reduction bilateral medial orbitofrontal cortex study suggests heterogeneity underpinned brain structural level result might useful understanding neurobiological mechanisms establishment precise treatment strategies elsevier ltd rights reserved
paper questions current use materials architecture furthers preference surface form inherent material properties investigates recent advancements towards notion digital materiality comparing various international research activities approaches concludes potentials smart materials creation dynamic adaptive spatial design focus work author represents number projects realized area within past years gives insight recently established materiability research network community platform reveals smart materials properties self make applied hands manner
research shown jurors heavily influenced secondary confessions may attribute informant motives good character rather incentive study investigated role race context manipulating defendant informant race black white informant type jailhouse civic duty whether informant received incentive testify participants read trial transcript provided verdict answered questions informant reason testifying attributions observed absence informant testimony participants convicted white defendant often also discovered effect incentive verdicts defendant white participants voted guilty less often informant received incentive effect incentive verdict defendant black informant race defendant race incentive showed combined effect verdict participants particularly suspicious less likely vote guilty black informant received incentive testifying black defendant effects race attributions research sheds light extralegal factors prevent jurors considering role incentives secondary confessions
paper introduces pscan port scanning based network covert channel violates non discretionary system security policy allow data transfer given process sender another given process receiver using pscan sender opens closes network ports way encodes covert data receiver performs synchronized port scanning procedure sender host determine ports open ones closed decodes data paper defines covert channel analyzes data rate stealthiness robustness addition paper investigates countermeasures channel
paper introduce sawd semi automated approach wrapping dynamic moving target cyber defenses cyber command control operations sawd provides interactive user interface enables intuitive description either explicitly example requirements pre conditions steps defense installation configuration operation multiple operational environments defense wrapping produces semantic representation defense well code necessary manage defense enables seamless demand deployment control across multiple operating systems sawd collaborative effort florida institute technology raytheon bbn technologies air force research laboratory
study nonlinear dynamics dimensional ferromagnetic spin system bilinear biquadratic interactions semiclassical limit dynamics found governed new integrable fourth order nonlinear schrodinger nls equation dimensions integrability identified using lax pair operators soliton solutions obtained using straightforward darboux transformation technique model hamiltonian representing dimensional spin chain varying bilinear biquadratic interactions also constructed inhomogeneity effects studied performing perturbation analysis moreover modulational instability aspects discussed analytical solutions graphical illustrations elsevier rights reserved
frequency response analysis fra technique used diagnose mechanical integrity transformer winding diagnostic tools enormous value since power transformers critical asset within electrical network minimize probability unexpected outage prevent catastrophic failure maintenance monitoring power transformers essential utilities past couple decades fra utilized line diagnosis method however recent development smart grid systems growing interest development line fra techniques paper proposes technique service monitoring power transformer winding deformation uses broad frequency sine wave voltage excitation signal high frequency current transformers conjunction bushings test taps experiments using system conducted validated single phase voltage transformer
simplified method design impermeable geosynthetic tubes inflated using liquid proposed paper adopting computer program existing theoretical model relationships pumping pressure geometric parameters geosynthetic tubes established set simplified dimensionless design equations derived using chapman richard curve fitting method validity simplified method verified using established methods laboratory model tests proposed simplified method thus used routine preliminary design elsevier ltd rights reserved
diverse molecules mediate cross kingdomcommunication bacteria eukaryotic partners determine pathogenic symbiotic relationships acyl homoserine lactone dependent quorum sensing signaling represses biosynthesis bacterial cyclodipeptides cdps act auxin signal mimics host plant arabidopsis thaliana work performed bioinformatics biochemical plant growth analyses identify nonribosomal peptide synthase nrps proteins pseudomonas aeruginosa involved cdp synthesis reverse genetics strategy allowed identification genes encoding putative multi modular nrps nrps mutations genes affected synthesis cdps cyclo pro val cyclo pro leu cyclo pro tyr showing wild type like levels virulence factors violacein elastase pyocyanin analyzing bioactivity purified naturally produced cdps found cyclo pro tyr cyclo pro val capable antagonizing quorum sensing lasr lasr dependent signaling contrasting manner cell free supernatants selected nrps mutants showed induction using bacteria plant interaction system show pvdj ambb pche aeruginosa mutants failed repress primary root growth improved root branching thaliana seedlings results indicated cdp production aeruginosa depended functional nrps influences quorum sensing bacteria plays role root architecture remodeling
paper presents new evolutions research works irwtl sjtu intelligentized technologies arc welding dynamic process robot systems including multi information sensing arc welding process characteristic extraction weld pool image voltage current sound arc spectral features multi information fusion algorithms prediction weld penetration intelligentized modeling welding dynamic process intelligent control methodology welding dynamic process intelligentized technologies robotic welding guiding tracking seam technology intelligent control weld pool penetration robotic welding process development autonomous welding robot system special environment ideas intelligentized welding manufacturing technology iwmt intelligentized welding manufacturing engineering iwme presented paper systematization intending researches applications intelligentized technologies modern welding manufacturing studies intelligentized welding presented paper establish foundation work intending researches applications intelligentized technologies modern welding manufacturing published elsevier ltd behalf society manufacturing engineers
users ambient intelligence environments overwhelmed huge numbers social media available thus identifying social media tailored user need becoming important question discussed paper adapts katz proximity measure use social tagging system help users ambient environment find relevant media suited interests method models ternary relations among user resource tag weighted undirected tripartite graph apply katz proximity measure tripartite graph experiments two real datasets implemented compared many state art algorithms experimental results prove adaptation katz algorithm tripartite structure yields significant improvement successfully ranks relevant search results according user interests
effective workforce essential delivery high quality chronic disease care low income nations challenged dearth maldistribution essential workforce required chronic disease care including chronic kidney disease ckd nephrology education training developed countries grown pace technological advancement practice medicine order meet standards required kidney health professionals towards high quality patient centered medical care standards designed institutions professional societies royal colleges medical councils high income nations well developed health systems infrastructures often easily translatable issues critical nephrology practice low income nations little guidance provided common nephrological issues regional nature pertaining ethnic minorities disadvantaged groups living countries emergent need training curriculum meets needs peculiarities developing nations needs leverage existing well validated systems training across globe evaluated nephrology training programs across upper middle high income nations identify best practices opportunities adoption low income nations reviewed training guidelines major professional societies content process training similarities differences structure content process training programs across countries clearly adoptable concepts frameworks application low income nations provide recommendations strategic plan future focus nephrology training developing world align current trends technological advancement development well need emphasis prevention ckd essential competencies patient population based required nephrologist developing world setting outlined practical measures action plan adoption
mental health impact parental detention deportation citizen children topic increasing concern forced parent child separation parental loss potentially traumatic events ptes adverse effects children mental health objective study examines post traumatic stress disorder ptsd symptoms psychological distress among latino born children ages living mixed status families least undocumented parent risk detention deportation method multiagent child parent teacher clinician standardized assessments conducted baseline assess child trauma psychological distress results analyses indicate ptsd symptoms reported parent significantly higher children detained deported parents compared citizen children whose parents either legal permanent residents undocumented without prior contact immigration enforcement similarly findings revealed differences child internalizing problems associated parental detention deportation reported parent well differences overall child functioning reported clinician addition teachers reported higher externalizing children exposure ptes conclusions findings lend support reconsideration revision immigration enforcement practices take consideration best interest latino citizen children trauma informed assessments interventions recommended special population
present comprehensive study list update problem locality reference specifically present combined theoretical experimental study theoretically proven experimentally observed performance guarantees algorithms match nearly match firstly introduce new model locality reference closely captures concept runs using model develop refined theoretical analyses popular list update algorithms secondly present extensive experimental study tested algorithms traces benchmark libraries theoretical experimental bounds differ percent new theoretical bounds substantially lower provided standard competitive analysis shows well known move front strategy exhibits best performance refined competitive ratio tends degree locality increases confirms move front method choice practice elsevier inc rights reserved
psychopathy research growing decades relatively new area research corporate psychopathy corporate psychopaths simply psychopaths working organizational settings may attracted financial power status gains available senior positions cause considerable damage within roles manipulative interpersonal style large scale fraud based upon prior studies analyze psychopathy research pertaining moral emotions classified according functional quality positive negative signal target self based upon review suggest psychopaths high moral emotions associated directed negative signals low self directed negative signals low directed positive signals found empirical articles related self directed positive signals understanding specific moral emotion deficits corporate psychopaths provides greater theoretical understanding practical implications knowing individuals promote though research needed moral emotions faked manipulative reasons
effective change order management important maintaining financial sustainability various stakeholders related construction projects minimizing cost overruns study propose zero cost risk management approach based collar option model order control loss caused change orders main cause cost overruns construction projects apply model actual projects empirical analysis analysis based projects indicates insurance buyers benefit collar option model cases insurance sellers cases cases insurance buyer owner according model owner experiences loss cost overrun caused change orders lower expected cases appropriate conclude loss caused collar option model absence additional revenue however insurance seller suffers loss cost overrun higher strike price call option thus insurance seller needs expertise construction management
objective several lines evidence suggest common pathophysiological mechanisms chiari malformation type cmi idiopathic intracranial hypertension iih hypothesized tonsillar ectopy typical finding cmi result elevated intracranial pressure icp combined developmentally small posterior cranial fossa pcf explore hypothesis authors specifically investigated whether icp comparable cmi iih whether intracranial volumes icvs different patients cmi iih could explain tonsillar ectopy cmi authors also examined whether symptom profile comparable patient groups methods authors identified cmi iih patients undergone overnight diagnostic icp monitoring period reviewed clinical records radiological examinations ventricular csf volume pcf volume pcfv total icv calculated initial mri studies using volumetric software static pulsatile icp scores overnight monitoring analyzed furthermore authors included reference ref group consisting patients undergone icp monitoring due suspected idiopathic normal pressure hydrocephalus chronic daily headache showed normal pressure values results sixty six patients cmi iih identified comparable demographics noted groups occurrence symptoms headache nausea vomiting comparable cohorts dizziness gait ataxia significantly common patients cmi whereas visual symptoms diplopia tinnitus significantly frequent patients iih cranial volume measurements pcfv icv cmi iih patients similar notably iih patients tonsillar descent qualifying diagnosis cmi extent tonsillar ectopy significantly different cmi iih cohorts also cohorts ref group pulsatile icp elevated cohorts without significant group differences however static icp significantly higher iih group conclusions study showed comparable elevated pulsatile icp indicative impaired intracranial compliance cmi iih cohorts static icp higher iih cohort data support hypothesis reduced pcfv combined increased icp causes tonsillar ectopy cmi even though impaired intracranial compliance seems common pathophysiological mechanism behind conditions mechanism explaining different clinical radiological presentations cmi iih remain undefined
phenomenon taking sharing selfies become widespread everyday life however previous studies selfie dealt effect experience selfie therefore examined effect selfie people took shared selfies based social comparison theory focused two psychological factors social sensitivity self esteem experiment manipulated context experiencing selfies participants asked take picture self portrait cup using smartphone instructed either post social media save smartphone participants social sensitivity assessed measuring reaction time social probe self esteem evaluated measuring size signatures found participants social probe decreased size signature decreased took shared selfie results suggest taking sharing selfies could result greater social sensitivity lower self esteem selfie takers elsevier ltd rights reserved
bim building information modeling chiefly form built model information sharing platform emerged powerful solution dynamic requirements aec architecture engineering construction however whereas fast accurate reconstruction building interiors essential collaborative construction management process manual creation utilization built model typically results low productivity erroneous modeling results paper proposes semi automated method accounts resolves major problems streamlined manual process built model creation bim method generates wireframe model combined clutter data imported bim tool built modeling present study evaluates proposed method applying two typical rooms test building built model subjected accuracy assessment using reference points acquired total station contributions proposed method compared fully manual operation reduction huge data size original point clouds improvement productivity built bim creation aid wireframes accuracy enhancement refinement process entails segmentation regularization however proposed method limited building interiors consisting planar structures modeling detailed objects windows doors unfortunately still requires manual operation thus research detail modeling refinement necessary order increase method automation enhancement overall suitability mapping complex indoor environments elsevier ltd rights reserved
dissociative experiences involving altered states consciousness long understood consequence response traumatic experiences reduced level consciousness may aid survival traumatic event indeed dissociative subtype post traumatic stress disorder ptsd added recently diagnostic statistical manual mental disorders edition dsm dissociative symptoms present across host neuropsychiatric conditions including ptsd psychotic spectrum illnesses anxiety mood disorders transdiagnostically presence dissociative symptoms associated greater illness burden reduced treatment outcomes critically dissociative symptoms related impaired performance measures attention executive functioning memory social cognition may contribute widespread cognitive dysfunction observed across psychiatric illnesses despite knowledge relation dissociative symptoms reduced cognitive function remains poorly understood review evidence linking dissociative symptoms cognitive dysfunction across neuropsychiatric disorders addition explore two potential neurobiological mechanisms may underlie relation dissociative symptoms cognitive dysfunction trauma related neuropsychiatric conditions specifically hypothesize functional sensory deafferentation level thalamus observed defence cascade model dissociation may underlie reduced attention arousal leading progressive cognitive dysfunction altered functional connectivity key brain networks implicated cognitive functioning may represent critical neurobiological mechanism linking dissociative symptoms cognitive dysfunction patients ptsd transdiagnostically authors published elsevier ltd
parafield gardens children centre early childhood development parenting recognised global peace school early years gpsey recognition process project promoting rights responsibilities children families facilitated partnering children families decision making project priority young children active role decision making age appropriate activities discussions children families developed deeper understanding child rights peace building global awareness social inclusion educational staff supported enhance child rights focus gpsey recognition celebration acknowledged child rights community cultural diversity outcome gpsey recognition significant process fostered community ownership participation social inclusion worth noting involving children decision making development promotes rights responsibilities make positive difference children locally globally
procurement key process construction project creates manages contacts procurement activities span identification requirements project closeout making perfect mode integrating organizational strategic directions lately strategic importance procurement widely acknowledged academics well industry professionals construction procurement complex process large number available options directions hoc statistics show modern initiatives sustainability life cycle costing standardization getting integrated procurement however unified view construction industry procurement project process paper presents comprehensive review traditional emerging procurement practices construction industry current procurement practices analyzed separating three segments processes methods policies furthermore strengths weaknesses traditional procurement methods reviewed detail final section contemporary developments construction procurement investigated article consolidates detailed knowledge construction procurement identified knowledge gap literature
paper introduced design digital clock function temperature display use chip part time running chip dsb part temperature detecting lcd part time temperature display adjust time keyboard interface circuit simple electron device used rather cheap may get started quickly operation clock system uses production microchip cord picf microcontroller design includes drive porta portc portd porie general digital ports use pins rao control lcd pins portc deliver needed data command lcd use pins reo control receive data adopt burst mode set receive data time use pin port dsb initialize chip get data temperature finally use pins portd receive data keyboard addition may adjust clock keyboard design functions time alarm clock run change voice broadcast functions year month day week display achieved
aimstudies association body composition body fat body muscle cognitive function rarely reported aim present study determine association wide range body composition measures cognitive function older adults methodsa total malaysian older adults aged years older recruited using multistage random sampling population based cross sectional study older adults recruited men completed assessments cognitive function body composition cognitive functions assessed using malay version mini mental state examination bahasa malaysia version montreal cognitive assessment digit span test digit symbol test rey auditory verbal learning test body composition included body mass index mid upper arm circumference waist circumference calf circumference waist hip ratio percentage body fat skeletal muscle mass resultsthe association body composition cognitive functions analyzed using multiple linear regression adjustment age education years hypertension hypercholesterolemia diabetes mellitus depression smoking status alcohol consumption found calf circumference appeared significant predictor cognitive tests among men women except rey auditory verbal learning test waist hip ratio detected significant predictor cognitive tests among women significant predictor bahasa malaysia version montreal cognitive assessment among men conclusionsthese results suggest need maintain muscle mass lower adipose tissue among older adults optimal cognitive function geriatr gerontol int
background migraine common cause headache childhood several studies investigated association migraine atopic diseases mostly adult population objective study aimed investigate association children methods case control study conducted across european tertiary care hospitals june august cases children aged years consulting migraine episode controls age range consulting minor injury history recurrent headache logistic regression analyses tested effect atopic diseases anti allergic therapies occurrence migraine results children migraine likely persistent asthma compared absence asthma odds ratio confidence interval less likely treated inhaled nasal corticosteroid antihistamine therapy median number monthly migraine episodes higher children persistent asthma interquartile iqr range compared children intermittent asthma iqr range non asthmatic children iqr range conclusion persistent childhood asthma associated increased risk migraine higher frequency migraine attacks history anti asthmatic anti allergic therapies associated decreased risk migraine children adolescents role therapies pathogenesis occurrence migraine needs elucidated huge potential impact terms public health
objective explore potential role spirituality medication related needs assessment integrated care chronically ill populations method systematic literature review conducted explore impact faith beliefs health medication adherence individuals depression hiv aids retrospective electronic medical record review adult hiv patients urban primary care clinic integrated mental health services conducted substance abuse mental illness symptoms screener samiss major depressive disorder mdd incidence preceding year history contact spiritual advisor convenience sample interviewed qualitatively assess potential medication therapy management needs medication related problems another sample examined utilizing daily spiritual experience scale results literature reports positive influence health behaviors coping outcomes poor medication adherence treatment decisions due patient passivity resistance spiritual advisor contact limited specific religion significantly associated mdd absence inversely related samiss depression poor health behaviors patient interviews reflected significance faith terms insight acceptance illness role need medications coping medication adherence illustrative model designed based literature data collection conclusion spiritual assessment may help identify positive negative influence health spiritual interventions could beneficial promoting adherence positive health outcomes research recommended
politics aristotle espouses exclusion women politics public realm although believes biological psychological inferiority women men politics argument grounded either claims assumption historical patriarchal greek household natural makes distribution gender roles within natural well naturalness coupled aristotle thesis natural ipso facto moral provides philosophical foundation debarment women public sphere
diagnostic approach myeloproliferative neoplasms according classification system hematological malignancies consider clinical molecular cytogenetic information well bone marrow histology diagnosis chronic myeloid leukemia requires presence bcr abl philadelphia chromosome negative negative myeloproliferative neoplasms constitute three main subtypes including primary myelofibrosis polycythemia rubra vera essential thrombocythemia three negative myeloproliferative neoplasms share many pathogenic characteristic jak mutations however differ prognosis progression myelofibrosis risk leukemic transformation currently various major points interest bone marrow examination myeloproliferative neoplasms one morphology megakaryocytes hallmark negative myeloproliferative neoplasms play crucial role separating different subtypes myeloproliferative neoplasms another reticulin fibrosis collagen fibrosis may detected bone marrow biopsy specimen reticulin trichrome stains respectively immunohistochemistry certain molecular techniques may applied bone marrow biopsies supporting evidence certain features myeloproliferative neoplasms
previous knowledge domains dependence hamilton jacobi equation useful study approximation information nature general difficult obtain directly data problem paper formally introduce concept independent sub domain discuss main properties provide constructive implicit representation formula results propose algorithm approximation sets shown relevant numerical resolution via parallel computing
demagnetization characteristics permanent magnet synchronous machine pmsm investigated using finite elements method done resolve partial demagnetisation pmsm rotor resulting short circuited magnetic field first turn phase belt ftpb paper first introduces electrical machine design parameters winding construction establishes pmsm model using ansoft maxwell software harmonic contents waveform studied investigating magnetic flux density distributions short circuit fault varied trajectories flux densities reference points rotor permanent magnet located different points load air gap magnetic flux density electromagnetic torque pmsm three phase currents harmonic content waveform addition reason ftpb short circuit determined provide theoretical basis diagnosis pmsm
purpose review irritable bowel syndrome ibs highly prevalent gastrointestinal disorder negative impact quality life represents substantial economic burden healthcare cost medical management ibs remains largely symptomatic review provides update related recently published diagnostic rome criteria ibs clinical trial data novel treatment modalities ibs targeting peripheral opioid receptors enteric nervous system gut microbiota recent findings new rome criteria define functional gastrointestinal disorders disorders gut brain interaction addition previously introduced pharmacological treatment modalities ibs constipation ibs synthetic peptides small molecules targeting gastrointestinal receptors ion channels newly food drug administration approved mixed peripheral opioid receptor agonist antagonist eluxadoline nonabsorbable antibiotic rifaximin demonstrate efficacy safety treatment ibs predominant diarrhea ibs summary diagnostic criteria functional gastrointestinal disorders including ibs revised rome defined gut brain disorders mixed peripheral opioid receptor agonist antagonist eluxadoline antibiotic rifaximin recently food drug administration approved treatment diarrhea predominant ibs ibs proven efficacy acceptable side effect profiles
paper presents methodology estimate dissipation energy hardware level abstraction powersim powersim class library aimed calculation energy dissipation hardware described systemc end operators monitored different energy model used data type energy models functions operator inputs constant parameters variables like supply voltage main advantage approach energy estimation require change source code describing hardware application examples computational complexity jpeg encoder implemented fpga fir filter implemented microcontroller presented elsevier rights reserved
learning new learning model based computer multimedia network based constructivism education theory humanistic education theory study limits classical methods computer graphic experiment learning paper implemented learning platform platform includes parts basic knowledge module tools material module learning communication module learning evaluation module platform improve interest enthusiasm student achieve better learning effect
background since hiv aids discovered studies demonstrated negative perceptions reluctance provide care affected people persist among nursing students throughout world leads poor quality care objectives report study explored socio cultural influences perceptions international nursing students toward caring people living hiv aids methods qualitative descriptive research design guided stigma theory utilised participants international australian undergraduate nursing students enrolled bachelor nursing program australian university data collected via semi structured interviews manual thematic analysis performed interview data findings three major themes emerged blame othering values perceptions influenced complex interrelated factors underscored culturally construed blame othering people living hiv aids perceived alien assumed homosexuals drug users promiscuous labelled bad people many participants compassionate others struggled differences personal values professional values expected registered nurse considerable variation degree participants willing embrace different perspectives values conclusion nursing curricula vital patient health wellbeing requires increased focus impact hiv aids important educators recognise simply providing information students necessarily change existing stigmatising perceptions addressing effect stigmatised marginalised society nursing care patients enhanced students must also reflect perceptions values embrace diversity elsevier ltd rights reserved
providing students opportunities appreciate interdisciplinary systems remains challenge educators levels sensing data logging environment engineered systems offer unique opportunity students explore connections engineering processes analog signals digital outputs present design device uses infrared sensor microcontroller measure record low liquid flow rates designed device using open source arduino microcontroller platform stand alone interface display data real time order demonstrate usefulness device undergraduate learning laboratory incorporated membrane distillation system building experimenting devices helps students practice learn creativity troubleshooting programming fundamentals allowing understand importance electrical engineering computer programming context chemical environmental engineering
due recent intensification international mobility europe citizens exposed much wider range lifestyles competing attitudes towards difference individuals therefore increasingly likely encounter strangers therefore required negotiate discontinuities contradictions values transmitted different sites response article explores concept stranger original data collected poland article highlights construction stranger depends national historical contexts core values related visions society poland different histories experiences social diversity impacting ways individuals negotiate strange encounters countries stranger often seen negative way relation minority groups perceived visibly different distinct unknown contemporary times poland largely articulated sexual prejudice homophobia whilst attitudes towards stranger largely conveyed religious prejudice islamophobia article offers means understanding encounters difference produce strangers different contexts
given possible importance anti citrullinated peptide protein antibodies acpa initiation progression rheumatoid arthritis extended knowledge different isotypes subclasses important present study analysed immunoglobulin subclasses regarding reactivity cyclic citrullinated peptides anti ccp among clinically well characterized patients recent onset relation smoking habits shared epitope status iga pan igg anti ccp antibodies patients regardless pan igg anti ccp status analysed igg ccp reactivity sixty nine per cent positive igg anti ccp subclass tested positive regarding igg igg igg igg anti ccp among ever smokers percentages igg anti ccp iga anti ccp positive cases significantly higher compared never smokers positive igg anti ccp subclass negative cases combining smoking data revealed igg igg anti ccp igg anti ccp isotypes associated expression although lower number patients positive igg igg anti ccp could however influenced results high levels igg anti ccp shown correlate expression non allele human leucocyte antigen hla drb conclusion study describe different risk factor characteristics across igg anti ccp subclasses igg appears similar iga anti ccp regarding predominant association smoking igg igg related distinctly carriage genes
securing networks large organizations technically challenging due complex configurations constraints managing networks requires rigorous comprehensive analysis tools network administrator needs identify vulnerable configurations well tools hardening networks networks usually dynamic fluidic structures thus one may incomplete information connectivity availability hosts paper address problem statically performing rigorous assessment set network security defense strategies goal reducing probability successful large scale attack dynamically changing complex network architecture describe probabilistic graph model algorithms analyzing security complex networks ultimate goal reducing probability successful attacks model naturally utilizes scalable state art optimization technique called sequential linear programming extensively applied studied various engineering problems comparison related solutions attack graphs probabilistic model provides mechanisms expressing uncertainties network configurations reported elsewhere performed comprehensive experimental validation real world network configuration data sizable organization
abstract present study examined individual differences susceptibility two similar forms memory distortion misinformation effect hindsight bias misinformation effect occurs individuals witness event provided misinformation recall original event containing elements misinformation hindsight bias occurs individuals make judgments provided feedback recall original judgments similar feedback actually seventy five participants completed misinformation task hindsight bias task several individual difference measures related memory distortions working memory capacity negatively correlated misinformation effect hindsight bias misinformation effect hindsight bias negatively correlated one another although misinformation effect hindsight bias measured similar designs predicted working memory capacity negative correlation suggests phenomena result somewhat different processes
aim systematically review literature addressing three key psychologically oriented controversies associated gastroparesis methods comprehensive search pubmed cinahl psycinfo databases performed identify literature addressing relationship gastroparesis psychological factors two researchers independently screened references inclusion criteria adult sample gastroparesis patients quantitative methodology least one following evaluation prevalence psychopathology outcome measure anxiety depression quality life evidence psychological intervention case studies review articles publications languages english excluded current review results prevalence psychopathology evaluated three studies found combined anxiety depression present gastroparesis cohort severe anxiety depression somatization level anxiety depression included outcome measure six studies limited research made difficult determine level anxiety depression cohort clear positive relationship gastroparesis symptom severity evident quality life included outcome measure studies gastroparesis patients reporting lower quality life population norms negative relationship quality life symptom severity one study assessed use psychological intervention gastroparesis patients found depression gastric function improved patients received psychological intervention however study considerable methodological limitations conclusion gastroparesis associated significant psychological distress poor quality life recommendations future studies development psychological interventions provided
nuclear power plants npps historically deployed cover base load electricity demand nowadays npps might perform daily load cycling operation load following rated power respect insertion control rods comparable action reduce nuclear power generation efficient alternative might load following cogeneration diverting excess power respect electricity demand auxiliary system suitable cogeneration system needs demand electricity heat region mwe gwt meet significant market demand access adequate input process flexible cogeneration might operate full load night request electricity low turned daytime economic standpoint essential investment auxiliary system profitable paper provides techno economic assessment systems potentially suitable coupling npp load following results show district heating desalination hydrogen might technically economically feasible elsevier ltd rights reserved
efficacy pulmonary vein antral isolation patients prolonged sinus pauses psp termination atrial fibrillation reported studied right atrial electrophysiologic electroanatomic characteristics patients forty patients underwent electroanatomic mapping psp group psp group paroxysmal supraventricular tachycardia control group group longer wave durations lead groups activation times group intervals longer adenosine triphosphate testing ablation ablation group complex electrograms compared group group significantly longer corrected sinus node recovery times pacing cycle length ablation larger volumes lower conduction velocities high posterior high lateral found patients psp upon termination atrial fibrillation electrophysiologic electroanatomic abnormalities warrant post ablation monitoring
impact mechanical forces pathogenesis airway remodeling functional consequences asthma remains fully established present study investigated effect repeated bronchoconstriction induced methacholine mch airway remodeling airway hyperresponsiveness ahr rats without sensitization external allergen provide evidence repeated bronchoconstriction using mch alone induces airway inflammation remodeling well ahr non allergen sensitized rats also found airways structurally functionally altered bronchoconstriction induced either allergen mch allergen sensitized animals finding provides new animal model development airway remodeling ahr mammals used studying complex reciprocal relationship bronchoconstriction airway inflammation studies presented animal models required clarify exact mechanisms underlying airway remodeling due bronchoconstriction functional consequences
aseptic loosening one main reasons revision total knee replacement tkr design key component tkr femoral component particularly problematic failure result different causes makes development new biomaterials use femoral component challenging task paper focuses engineering design aspects order understand limitations current materials design deficiencies paper describes introduction new biomaterial femoral component justifies recommendation use multi functional materials possible solution aseptic loosening potential advantages applying functionally graded biomaterials fgbms prosthetic femur explained reducing leading causes failure including wear micro motion stress shielding effect ideas presented paper used basis research feasibility advantages applying fgbm superior implant designs elsevier ltd rights reserved
tradition wife adopting husband surname continues widely endorsed within many nations current research focuses perceptions heterosexual women violate tradition specifically examined women retain surname evaluated respect marriage commitment personality attributes also tested sources individual variation evaluations three studies carried total undergraduates women men two universities participants study rated woman retained surname lower marriage commitment woman adopted husband surname also allocated high proportion agentic traits studies demonstrated women men high social dominance orientation sdo especially likely rate woman retained surname lower marriage commitment collectively findings indicate women violate marital surname tradition may encounter negative stereotypes marriage commitment stereotypes may particularly likely originate people preference group based inequality implications center links marriage traditions broader patterns gender inequality
nail scabies interesting clinical presentation scabies although usually found concomitant characteristic dermatologic manifestations may present isolated finding immunocompromised host condition commonly mistaken diseases nail dystrophy nail psoriasis onychomycosis report two cases unusual nail presentations provide clues diagnosis also literature unusual nail dermatologic presentations reviewed recognize dermatologist consideration appropriate treatment options
year old man presented chronic headaches intermittent blurred vision previous neuroimaging blood work reportedly normal papilledema questioning elicited history extensive alcohol use unexplained weight loss night sweats magnetic resonance imaging brain demonstrated communicating hydrocephalus leptomeningeal enhancement patient underwent ventriculoperitoneal shunt placement leptomeningeal biopsy initially unrevealing cerebrospinal fluid eventually yielded positive titers coccidioides diagnosis confirmed biopsy culture results elsevier inc rights reserved
background dermatophytosis important superficial fungal infection affects nearly human population worldwide recurrence disease emerging resistance trichophyton rubrum synthetic antifungals main problems control dermatophytosis purpose study evaluate effect cold atmospheric plasma cap rubrum growth ergosterol biosynthesis keratinase activity methods cap system comprised helium oxygen used trichophyton rubrum conidia suspensions treated cap time periods well microplates fungal growth evaluated counting colony forming unit cfu fungal dry weight ergosterol biosynthesis keratinase activity evaluated cap treated rubrum untreated controls results rubrum growth significantly inhibited cap strongly suppressed fungal ergosterol biosynthesis keratinase activity increased cap exposure conclusion results demonstrated first time cap inhibits rubrum growth suppresses ergosterol biosynthesis increases moderately keratinase activity dose dependent manner overall cap exposure could potentially useful method treatment clinical cases human animal dermatophytoses elsevier inc rights reserved
paper conduct research project driven alliance college enterprise teaching mode applications contemporary vocational education achieve aim higher education popularization country vigorously develop vocational education important way higher vocational education national local economic development purpose training production construction management service first line need cultivate high quality personnel higher vocational education social demand primary guidance employment education cultivate students technology applied talents skills research proposes novel guideline deal mentioned issues applicable
objective study investigate whether potentially inappropriate medication pim use predictor mortality community based population older adults cohort study performed january december based data representative sample population aged years older living bambui brazil univariate multivariate analyses association variable interest use pim pharmacological groups pim mortality based extended cox model proportional hazards extended model adopted include measurement exposure interest throughout follow period baseline adjustment variables included sociodemographic characteristics health status use health care services medications level significance adopted analyses prevalence pim use multiple adjustments risk death among users least one pim higher among use pim among pim groups analyzed antipsychotics strongly associated mortality study revealed high prevalence pim use among community based aged population also identified pim use predictor mortality group individuals indicates need selection safer drug therapy alternatives patient group
nmr spectroscopy indispensably powerful technique analysis biomolecules ambient conditions structural functional studies however practice complexity technique often frustrated application non specialists paper present ccpnmr version latest software release collaborative computational project nmr aspects nmr data analysis including liquid solid state nmr data software designed simple functional flexible aims ensure routine tasks performed straightforward manner designed software according modern software engineering principles leveraged capabilities modern graphics libraries simplify variety data analysis tasks describe process backbone assignment example flexibility simplicity implementing workflows well toolkit used create necessary graphics workflow package downloaded www ccpn software downloads freely available non profit organisations
new degree industrial technology engineering arising bologna process education system takes new approach placing student centre teaching learning process purpose lecturers innovate improve functions explaining concepts visual way turning learning process attractive moreover important enhance independent learning focused creation opportunities experiences necessary students become capable self reliant self motivated life long learners context focused attention basical subject called elasticity strength materials given third course topic provides fundamental knowledge deal important fields mechanical engineering structural analysis machine design throughout course students become familiar fundamental concepts structural engineering mechanics stress strain strength stiffness stability subject divided two parts first one discusses theoretical foundations theory elasticity studying stress strain fields elastic solid subjected load system second part study made simplified models strength materials years teaching noticed students difficulties understand learn first part abstract less intuitive order enhance curriculum development students complement theoretical basis explained lectures use photoelasticity device available students workshop practices elasticity strength materials photoelasticity experimental non destructive technique evaluates stresses strains elastic solid optical refraction appearing particular material subjected mechanical loads technique requires resources making suitable teaching small labs teaching practices students invited reproduce physically problems analytically raised solved class see stress strain results different points particular solid different colors visual attractive furthermore practice conceived multidisciplinary task since offered students opportunity resolve problem finite element analysis addressed subsequent courses students divided different groups solve analytically experimentally different case problems gain new skills abilities field mechanical engineering improving problem solving competences promoting teamwork cooperativity among students way productive enriching discussion encouraged comparison theoretical results experimental reality improving reasoning critical spirit students
purpose review rise prevalence food allergy past decades focused attention factors may impact disease development notably gut microbiota gut microbial communities play crucial role promoting oral tolerance alteration factors cesarean section delivery diet antibiotics may influence disease development review highlights recent progress understanding role gut microbiota development food allergy recent findings food allergy associated alterations gut microbiota dysbiosis early life may predictive disease persistence versus tolerance acquisition evidence benefits adjunct therapy probiotics prevention food allergies potentiating oral immunotherapy remains circumstantial studies needed validate use studies murine models food allergy suggest microbial therapy protolerogenic bacteria certain clostridial species holds promise future applications prevention therapy food allergy summary progress understanding role dysbiosis food allergy factors promote development antibiotic therapy diet modes infant delivery environmental exposures offer windows opportunity preventive therapeutic interventions stem rising tide food allergy epidemic
due depletion fossil fuel many developing countries like pakistan facing energy crisis last decade pakistan suffered greatly economically due energy crisis government level private sector great effort made overcome energy crisis abundantly available energy sources solar energy one cleanest omnipresent energy source solar tracker systems gaining popularity due wide spread solar energy use alternative energy source compared fossil fuel obtain optimum energy solar system accurate tracking sun required respect azimuth tilt angle usually two types solar trackers one single axis dual axis types solar trackers motor based servo systems used precise movement control consider present work designing optimum proportional integral derivative pid controller motors dual axis solar tracker system problem formulated optimization problem three swarm intelligence based metaheuristic algorithms namely particle swarm optimization pso firefly algorithm ffa cuckoo search algorithm csa employed optimum tuning pid controller study shows csa superior compared ffa pso due faster convergence rate small variance standard deviation design parameters obtained also pertaining performance domain ffa csa show better performance compared pso problem domain study elsevier inc rights reserved
present time radar methods seas oceans diagnostics actively developing using radar stations based satellites planes allows receive information sea surface atmosphere near surface layer coverage big water surface areas independently day time developed methods satellite radio images processing applied marine radar stations institute applied physics ras works sea surface diagnostics systems development basis standard marine radar actively conducted despite smaller coverage territory comparison satellite data marine radar possibility record spatially temporary radar images receive information surrounding situation quickly work deals results researches conducted within international expedition atlantic ocean autumn route rotterdam netherlands ushuaya argentina antarctica ushuaya expedition complex measurements sea surface atmosphere near surface layer parameters subsurface currents wide range hydroweather conditions including storm carried system developed iap ras basis marine radar icom rii adc analog digital converter block data recording personal computer used display non uniform near surface current sea surface radar images storm conditions shown means high speed anemometer meteorological station measurements atmosphere parameters carried comparison anemometer data calculated radar images carried dependence radar cross section wind speed wide range wind speeds including storm conditions investigated possibility marine radar using surface waves intensity ice situation estimates also icebergs detection shown
agony accompanies incidence symptoms temporomandibular disorders tmds important concern oral maxillofacial region objective study explore clinical findings centric relation occlusal splint cros treatment intra articular injection treatment liquid phase concentrated growth factors lpcgfs patients disc displacement without reduction ddwor group investigation retrospective cohort study included patients ddwor received treatment april march predictor variable therapeutic method outcome variables included joint crepitus sound visual analog scale vas temporomandibular joint tmj arthralgia tmd associated headache myofascial pain referral deviation mandible opening dom maximal interincisal opening mio stage cros treatment evaluation variables adopted individual unit stage lpcgf injection evaluation joint sound adopted joint unit whereas variables adopted individual unit among patients males females distribution age ranged years mean age years cros treatment except joint crepitus sound failed achieve significant improvement symptoms dom tmd associated headache myofascial pain referral tmj arthralgia mio achieved statistically significant improvements lpcgf injected cros treatment joint crepitus sound symptoms relieved average days cros alone alleviate tmd clinical symptoms except joint crepitus sound approximately joint crepitus sounds could improved within days average lpcgf injected comparisons still required future effects therapeutic methods
mobile hoc networks manets wireless networks wide range applications dynamic topologies ease deployment owing independent dynamic nature mobile nodes topology manet often changes prone various attacks therefore substantial research area security required certificate revocation effective mechanism providing network security services however existing schemes well suited manets considerable overhead low accuracy respect certificate revocation study authors investigate distributed certificate revocation protocol basis game theoretic model design new voting based security scheme game based security paradigm provide ability practically respond current system conditions suitable real manet operations simulation results demonstrate effectiveness efficiency scheme respect certificate revocation finally discuss results evaluation provide outlook future work field
physical model proposed enable unified thermodynamic treatment vacancy bearing solid gas also solves long standing controversy modeling vacancies solids within calphad approach model parameters related quantities calculated first principles measured experimentally vapor pressure tungsten calculated using proposed model methods achieving satisfactory agreement experimental data pointed site fraction order parameter present model used describe sublimation acta materialia inc published elsevier ltd rights reserved
lygia fagundes telles novel meninas portrays oppressive social atmosphere brazil authoritarian military dictatorship way novels accomplish though novel eschews documentary romance reportagem mode famously adopted writers period meninas provides poignant expression psychological emotional burdens caused living authoritarian regime presenting interior psychological lives three young women unique tri voiced stream consciousness narration novel unveils examines stereotypes gender roles assigned women brazilian society time novel resists patriarchal authoritarianism insidiously remains ingrained social structure family
two stage large capacitive load amplifier multiple cross coupled small gain stages proposed paper cross coupled structure small gain stages augments large signal responses providing significant improvement effective output stage transconductance hence gain bandwidth product gbw implemented standard cmos technology powered supply current consumption proposed amplifier achieves gbw mhz phase margin degrees driving capacitive load average slew rate chip compensation capacitor active chip area
urbanization natural social process involving simultaneous changes earth land systems energy flow demographics economy understanding spatiotemporal pattern urbanization increasingly important policy formulation decision making natural resource management combination satellite remote sensing patch based models widely adopted characterize landscape changes various spatial temporal scales nevertheless validity type framework identifying long term changes especially subtle gradual land modifications seriously challenged paper integrate annual image time series continuous spatial indices non parametric trend analysis spatiotemporal study landscape dynamics phoenix metropolitan area harness local indicators spatial dependence modified mann kendall test describe monotonic trends quantity spatial arrangement two important land use land cover types vegetation built areas results suggest declines vegetation increases built areas two prevalent types changes across region vegetation increases mostly occur outskirts new residential areas developed natural desert sizable proportion vegetation declines built increases seen central southeast part extensive land conversion agricultural fields urban land use one important driver vegetation declines xeriscaping practice also contributes part vegetation loss increasingly heterogeneous landscape quantitative framework proposed study provides pathway effective landscape mapping change monitoring spatial statistical perspective
children acquire propositional attitude folk psychology theory mind orthodox answer central question developmental tom research long around age children begin apply belief propositional attitude concepts orthodoxy recently come serious attack though two sides scoffers complain estimates children early competence claim proper understanding propositional attitudes emerges much later boosters criticize orthodoxy underestimating early competence claim even infants ascribe beliefs paper orthodoxy defended empirical grounds two kinds attacks basis new evidence two attacks safely countered orthodox claim actually strengthened corroborated refined emerges around age explicit unified flexibly conceptual capacity ascribe propositional attitudes unified conceptual capacity contrasts less sophisticated less unified implicit forms tracking simpler mental states present ontogeny long refined version orthodoxy thus plausibly spelled form systems account theory mind
muckle wells syndrome mws rare autoinflammatory disease study aimed report clinical features gene variations first case series mws patients chinese population four han chinese patients diagnosed mws followed adult clinic autoinflammatory diseases relevant phenotypes genotypes collected patients adult male median age disease onset years one patient adult onset disease positive family history observed patients remittent disease course duration fever attacks ranged days skin rashes present patients manifestations included polyarthralgia arthritis oral ulcers conjunctivitis myalgia headache pharyngitis abdominal pain severe sensorineural hearing loss chronic meningitis communicating hydrocephalus none patients showed evidence renal amyloidosis patient carried heterozygous mutation nlrp gene including respectively variants novel mutations exon nlrp patients good response corticosteroids study suggests mws could identified chinese population finding novel mutations nlrp may expand diversity mws
article draws upon recent geographical work assemblage reconsider understand alternative food economies particular brings attention devices upon economies relyspecifically plastics since mid twentieth century plastics developed close complex relations agrifood systems facilitate commodity valuation product circulation worldwide also recognised problematic due environmental human health impacts despite paradox attention plastics increasingly receive know little relations alternative food initiatives afis plastics inhabit alternative food economies associations circulations become performed markets look like device oriented perspective address questions paper draws fieldwork undertaken brisbane australia two afisa weekly organic market online box program wholesaler using visualisation assemblage approach discloses presences flows functions tensions plastics afis way plastics revealed also act reveal alternative food economies analysis steps away evaluations afis effective challenge neoliberalisation consider complex processual sometimes ambivalent efforts distribute good food engage important ways things like plastics
background study involving three hiv clinics canadian provinces newfoundland labrador manitoba sought identify ethical issues involving health care providers clinic clients settings gain understanding different ethical issues managed groups methods used institutional ethnographic method investigate ethical issues hiv clinics researcher conducted depth semi structured interviews compiled participant observation notes studied health records order document ethical issues clinics understand health care providers clinic clients manage resolve issues results found health care providers clinic clients developed work processes managing ethical issues various types conflicts client autonomy public health priorities treatment prevention difficulties associated criminalization nondisclosure hiv positive status challenges non adherence hiv treatment protection confidentiality barriers treatment access negative social determinants health well conclusions ethical issues resulted structural disadvantages experienced clinic clients striking findings study negative social determinants health well experienced clinic clients experiences violence trauma poverty racism colonization homelessness factors affecting well problematic substance use negative determinants root ethical issues ethical concern
novel optimized numerical method modeling exciton polariton superfluid semiconductor microcavity proposed exciton polaritons spin carrying quasiparticles formed photons strongly coupled excitons possess unique properties interesting point view fundamental research well numerous potential applications however numerical modeling challenging due structure nonlinear differential equations describing evolution paper propose solve equations modified runge kutta method order optimized efficient computations algorithms implemented form programs fitted parallel environments utilizing vector instructions programs form epcgp suite used theoretical investigation exciton polaritons program summary program title epcgp catalogue identifier afbq program summary url http cpc qub summaries afbq html program obtainable cpc program library queen university belfast ireland licensing provisions bsd lines distributed program including test data etc bytes distributed program including test data etc distribution format tar programming language openmp extensions main numerical program python helper scripts computer modern tested amd intel processors blx operating system unix linux windows code vectorized parallelized yes openmp ram single run classification nature problem exciton polariton superfluid novel interesting physical system allowing investigation high temperature bose einstein condensation exciton polaritons quasiparticles carrying spin brought lot attention due unique properties potential applications polariton based optoelectronic integrated circuits equilibrium quantum system confined within semiconductor microcavity described set nonlinear differential equations similar spirit gross pitaevskii equation unique properties allow standard solving frameworks utilized finding accurate efficient numerical algorithm well development optimized numerical software necessary effective theoretical investigation exciton polaritons solution method runge kutta method order employed solve set differential equations describing exciton polariton superfluids method fitted exciton polariton equations optimized programs utilize openmp extensions vector operations order fully utilize computer hardware running time evolution depending values parameters elsevier rights reserved
purpose investigation estimate document reliability validity anterior knee pain scale akps estimate relative prediction accuracy anterior knee pain young females data prospective epidemiologic study diagnose patellofemoral knee pain among female athletes using anterior knee pain scale akps data treated phases descriptive phase reliability phase scale refinement phase final validation stage focused effort test document validation akps short form perform head head comparisons item short form original item form akps reduced items alpha coeff sigma sem items alpha coeff sigma sem point biserial correlations patellofemoral pain diagnosis comparable short form long form sensitivity short form long form specificity short form long form auc current analyses indicate subset measures akps responsive patellofemoral pain symptoms may support screening related diagnoses simpler quicker scale optimized diagnostic accuracy could reduce demand patients clinicians research teams focused identification management patellofemoral pain iii
aggregation specific proteins plays pivotal role etiopathogenesis several neurodegenerative diseases nds beta amyloid beta peptide containing plaques intraneuronal neurofibrillary tangles composed hyperphosphorylated protein tau two main neuropathological lesions alzheimer disease meanwhile parkinson disease defined presence intraneuronal inclusions lewy bodies alpha synuclein alpha syn identified major protein component current literature provides considerable insights mechanisms underlying oligomericrelated neurodegeneration well relationship protein aggregation thus facilitating development novel putative biomarkers pharmacological targets recently alpha syn tau beta shown interact pathological proteins form toxic heteroaggregates latest findings overcoming concept neurodegenerative disease related misfolding single specific protein review potential opportunities pharmacological approaches targeting alpha syn tau beta oligomeric forms highlighted examples recent studies protein aggregation biomarker nds brain peripheral fluids deeply explored finally relationship biomarker establishment assessment use diagnostics therapeutic targets discussed elsevier inc rights reserved
nowadays online resources play important role teaching learning thanks new advances technology importance enhanced scientific areas even distance education universities classic hands laboratories always possible reason face toface laboratory practices replaced even complemented online virtual remote laboratories vrl normally applications arc developed high level programming tools greater lesser extent use java unfortunately newly discovered java security issues impossibility run java smart devices restriction dissemination kind applications work first step towards get new structure easy java javascript simulations ejss allows remote connection hardware devices regard first objective solve problems java applications using ejss proposed solution provides user structure reuse vrls using java model runs server linked javascript graphical user interface client device
present study describes atypical leydig cell hyperplasia week old sprague dawley rats low testosterone high luteinizing hormone levels prenatal administration day butyl phthalate days postconception light microscopy revealed hyperplasia surrounded severely degenerated seminiferous tubules aggregated lcs large ovoid nuclei nucleoli abundant eosinophilic cytoplasm immunohistochemical analysis showed expression proliferating cell nuclear antigen vimentin many hyperplastic lcs electron microscopy revealed atypical nuclei abundant free ribosomes stripped rough endoplasmic reticulum intermediate size filaments elongated cytoplasmic filopodia atypical tight junctions cilia formations smooth endoplasmic reticulum scarcely observed
objective evaluate length interval onset initial management bipolar disorder method conducted meta analysis using preferred reporting items systematic reviews meta analyses guidelines systematic searches located studies reporting estimates age onset aoo indicators age initial management calculated pooled estimate interval aoo age management factors influencing study heterogeneity investigated using sensitivity analyses meta regression multiple meta regression results twenty seven studies reporting samples total patients met inclusion criteria pooled estimate interval onset management years standardized difference confidence interval high sample heterogeneity longer interval found studies defined onset according first episode compared onset symptoms illness defined management age diagnosis rather first treatment first hospitalization longer interval reported among recently published studies among studies used systematic method establish chronology illness among studies smaller proportion bipolar patients among studies earlier mean aoo conclusions currently little consistency way researchers report aoo initial management however large interval onset management presents opportunity earlier intervention
paper investigate dimensional derivative nonlinear schrodinger dnls hierarchy fold darboux transformation applied lax pair associated dimensional dnls equation general explicit formula soliton solution derived terms vandermonde like determinant expression zero background two different families soliton solutions multi line soliton multi parabola soliton solutions constructed applying darboux transformation successively characteristics propagation direct wave vector frequency two types solitons analyzed interactions line solitons two parabola solitons well one line soliton different direction one parabola soliton respectively displayed based figures several sample solutions
alzheimer disease common neurodegenerative disorder characterized progressive loss cognition million individuals currently worldwide unfortunately current therapies limited modest symptomatic relief brains patients characterized deposition amyloid beta hyperphosphorylated forms tau protein brains also show neurodegeneration high levels oxidative stress inflammation phytocannabinoid cannabidiol cbd possesses neuroprotective antioxidant anti inflammatory properties reduces amyloid beta production tau hyperphosphorylation vitro cbd also shown effective vivo making phytocannabinoid interesting candidate novel therapeutic interventions especially lacks psychoactive cognition impairing properties cbd treatment would line preventative multimodal drug strategies targeting combination pathological symptoms might ideal therapy thus review present brief introduction biology current treatment options outlining comprehensively cbd biology pharmacology followed vitro vivo evidence therapeutic potential cbd also discuss role endocannabinioid system commenting potential future cbd therapy including safety aspects wolters kluwer health inc rights reserved
intrauterine contraception widely used highly effective reversible means birth control one potential disadvantage use intrauterine devices iuds risk uterine perforation process iud insertion possibility perforate wall uterus health workers might injure fundus uterus due inadequate knowledge insufficient training paper discusses development smart iud launcher insertion system would used prevent perforation uterine wall detecting specific distance wall safe release iud using sensor several launcher prototypes developed prior final version iud launcher results testing experiments conducted evaluate performance proposed device show sensor able detect distance also capable detecting distance target even high viscosity liquid developed prototype promises solution accurate iud insertion could used training module health care providers helping remove fear using long lasting contraceptive method promote affordable modern contraceptive method society
objective study aimed determine radiation dose temporal bone computed tomography tbct detect pediatric congenital cholesteatoma suggests strategy lowering perioperative radiation dose methods fifty three patients followed months surgery perioperative clinical findings effective radiation dose tbct investigated patients mean age initial tbct months mean follow period months results patients one tbct performed postoperatively postoperative imaging performed evaluate second stage ossiculoplasty due suspicion recurrence examinations part follow tbct performed two occasions surgery part follow difference distribution stage type compared patients subjected tbct less three occasions respectively recent follow cases recurrence mean erd single tbct msv mean cumulative erd tbct msv per patient conclusion mean cumulative erd tbct performed cases high consider radiation hazard however efforts minimize number scans taken basically published elsevier ireland ltd
research evolutionary psychology suggests mere presence eye images promote prosocial behavior however eye images effect source considerable debate findings across studies yielded somewhat inconsistent support suggest one critical factor may whether eyes really need watching effectively enhance prosocial behavior three experiments investigated impact eye images prosocial behavior assessed laboratory setting participants randomly assigned view image watching eyes eyes direct gaze image nonwatching eyes eyes closed study averted eyes studies image flowers control condition upon exposure stimuli participants decided whether help another participant completing dull cognitive task three independent studies produced somewhat mixed results however combined analysis three studies total participants showed watching component eyes important decision making context images watching eyes led significantly greater inclination offer help compared images nonwatching eyes eyes closed averted eyes images flowers findings suggest eyes gazing individual rather proxy social presence eyes serve reminder reputation taken together conclude eyes pay attention lift veil anonymity potentially facilitate prosocial behavior
pilot study assessed feasibility acceptability outcomes referring breast cancer survivors get healthy service ghs state health funded month telephone delivered lifestyle program pre post study eligible consenting women following treatment stages iii breast cancer referred nurses cancer treatment centre ghs feasibility assessed via ghs uptake completion acceptability assessed via patient satisfaction nurse feedback changes weight physical activity diet quality life qol fatigue baseline months examined fifty three women mean body mass index age years months post diagnosis born outside australia high school less education english second language took ghs completing program almost completers high satisfaction ratings breast nurses provided positive feedback findings ghs completers show statistically significant effect baseline months weight loss mean total physical activity minutes per week min week significant changes fruit vegetable servings per day takeaways fast food frequency per week observed significant improvement mental qol observed physical qol fatigue ghs referral appeared feasible acceptable effective diverse group women following completion treatment breast cancer yet remains done fully integrate ghs screening referral usual care
paper derive approach effective utilization thermodynamic data phase field simulations widely used methodology multi component alloys following work eiken wherein extrapolative scheme utilized conjunction interface deriving driving force phase transformation corresponding simplistic method based formulation parabolic free energy model incorporating thermodynamics laid binary alloys work folch plapp following extend latter approach multi component alloys framework grand potential formalism coupling applied case binary eutectic solidification alloy two phase solidification ternary eutectic alloy thermodynamic justification entails basis formulation places context bigger picture integrated computational materials engineering elsevier ltd rights reserved
introduction chart review low cost highly informative method describe symptoms treatment risk factors associated borderline personality disorder bpd adapt screening intervention clinical reality previous chart review studies report aggressiveness anger psychotic features youths bpd show adverse family environment parental psychopathology constitute important factors bpd pathology objectives examine clinical characteristics depressed bpd adolescents years old outpatients according gender explore variables associated bpd traits methods retrospective chart review using child adolescent version retrospective diagnostic instrument borderlines conducted depressed adolescents bpd traits depressed patients without bpd traits participants reached retrospective diagnostic instrument borderlines threshold bpd included bpd traits group comparison analyses performed using pearson chi square test associated factors determined using regression analyses results bpd traits participants characterized higher family problems parental psychopathology parent disagreement argument parent child relational problem aggressive symptoms higher rates family intervention hospitalization number familial factors parental history delinquency substance use personality disorders siblings parental disagreement argument boys associated bpd traits attention seeking problematic functioning adapt well group activities also associated bpd traits discussion study stresses need assess bpd traits adolescent psychiatric evaluation especially presence aggressive behaviors family problems attention seeking results also highlight importance exploring family characteristics intervention adolescents bpd traits
areas world vitamin levels low months year intakes calcium high high prevalence osteoporosis cardiovascular disease suggests public health message avoiding calcium supplements increasing vitamin intake message could welcome vitamin given bolus calcium must taken daily may poorly tolerated approach based evidence intervention studies randomized controlled trials rcts suggest vitamin given calcium elicits small reduction fracture risk deaths demonstrated given alone cardiovascular safety calcium vitamin cad supplements difficult ascertain due weaknesses rct designs adjudication remedied subanalysis moreover major new rcts process provide better evidence remains unclear calcium dietary sources health advantages supplements benefits may confined patients poor nutritional intake small effects societal levels may derived large effects small number patients impossible confirm given limited information baseline vitamin calcium status entry trials future intervention studies carefully capture baseline characteristics may determine strength response make efficient use randomization strategies allowing subsequent disassembly subanalyses maintaining balancing though large clinical rcts currently evaluate effects higher vitamin doses equivalent current research effort regarding calcium controversy absence studies possible provide clinicians evidence based recommendations regarding best use cad supplementation
recently ubiquitous manufacturing attracted wide attention academia industry create successful ubiquitous manufacturing system efficient material handling system essential accordance reason mobile robots used transporting materials paper aims developing methodology scheduling material supply single mobile robot ubiquitous manufacturing environment type environment processing rate materials along supply quantity corresponds cycle material supply carrying capacity robots limited thus problem determining material supply quantity material supply schedule without lack materials production service processes becomes complicated work nonlinear program formulated schedule supply material determine required material quantity heuristic algorithm based genetic algorithm developed solve problem numerical experiments conducted study observed proposed algorithm shows good performance also implemented solve large scale problems elsevier ltd rights reserved
prevalence weight problems increasing worldwide growing evidence high body mass index bmi associated frontal lobe dysfunction cognitive deficits concerning mental flexibility inhibitory control efficiency present study aims replicating extending observations compared cognitive control performance normal weight bmi university students task tapping either inhibitory control experiment interference control experiment experiment replicated previous findings found less efficient inhibitory control overweight individuals experiment complemented findings showing cognitive control impairments associated high bmi also extend ability resolve stimulus induced response conflict engage conflict driven control adaptation present results consistent extend previous literature showing high bmi young otherwise healthy individuals associated less efficient cognitive control functioning elsevier ltd rights reserved
bit pipelined analog digital converter adc presented operational amplifier amp sharing technique bit redundant stages based switched capacitor circuits inverter based comparators digital gain error calibration used reduce power consumption adc relax amp requirements simulation results matlab simulink structure level cadence virtuoso schematic level cmos provided pipelined adc achieves sinad sfdr consumes supply fom conv
automated real time control electrical network achieved estimation state using phasor measurement units given undirected graph representing network study problem finding minimum number phasor measurement units place edges graph fully observed problem also known power edge set problem variant power dominating set problem naturally modeled using iteration indexed binary linear program whose size turns large practical purposes use fixed point argument remove iteration indices obtain compact bilevel formulation reformulate latter single level mixed integer linear program performs better natural formulation lastly provide algorithm solves bilevel program directly much faster commercial solver solve previous models also discuss robust variants extensions problem wiley periodicals inc networks vol
study attempt made optimize performance double basin solar still dimension lower basin dimension upper basin lower basin glass cover sides still receive direct sunlight external energy sources reflectors flat plate collector mini solar pond integrated double basin still productivity single basin still double basin still external modifications double basin still reflectors double basin still reflectors coupled flat plate collector mini solar pond day respectively productivity double basin still double basin still reflectors double basin still integrated flat plate collector mini solar pond respectively higher single basin still modifications increased performance lower basin upper basin relative contribution lower basin improved elsevier rights reserved
filters main ingredients many cosmetics personal care products significant amount lipophilic filters annually enters surface water due large numbers swimmers sunbathers nature compounds cause bioaccumulation commercial fish particularly estuarine areas consequently biomagnification food chain occur study estimated amount four common filters ethylhexyl methoxycinnamate ehmc octocrylene butyl methoxydibenzoylmethane dbm benzophenone may enter surface water gulf mexico data analysis based available research data epa standards age classification human body parts results indicated among counties texas coastal zones nueces beaches high potential water contamination filters ehmc year year dbm year year refugio county minimum number beaches indicated lowest potential filter contamination sensitive estuarine areas galveston receive significant amount filters article suggests action protecting texas estuarine areas controlling number tourists ecotourism occurs sensitive areas gulf mexico institute oceanology polish academy sciences production hosting elsevier
psychological evidence predicts environmental conditions seasons weather associated mood finance literature documented links daily stock market returns paper examine conditions affect art auction prices england find amount daylight auction day significant positive effect selling prices model specifications addition find specifications direct positive effects stemming hours sunshine day precipitation temperatures whether daylight hours getting longer shorter published elsevier inc
jak mutations define polycythemia vera calr mpl mutations specific jak unmutated essential thrombocythemia primary myelofibrosis pmf overviewed current knowledge relationship phenotypic driver mutations thrombotic complications major cause morbidity mortality patients myeloproliferative neoplasms mpn particularly jak mutation found patients pmf international prognostic score thrombosis ipset thrombosis identified jak mutation independent risk factor tiered prognostic model devised ipset thrombosis model outperformed tiered conventional risk stratification includes age thrombotic history usually associated jak mutation studies looking role jakvf allele burden associated thrombosis far inconclusive pmf rate major thrombosis around jak mutation emerged independent risk factor events calreticulin mpl calr second frequent mutation occurs half jak mpl wild type patients pmf despite fact mutations associated high platelet counts risk thrombosis compared jak mpl mutated cases significantly lower role mpl prediction thrombosis difficult demonstration due low frequency pmf therefore epidemiologic studies pointed role jakvf mutation major contributory factor pathogenesis thrombosis mpn abnormalities blood cells arising clonal proliferation hematopoietic stem cells may explain switch procoagulant phenotype elsevier ltd rights reserved
time delays dead time found many processes industrial practice time delays mainly caused time required transport mass energy information many cases time delay caused effect produced accumulation large number low order systems one possibilities control processes approximation lower order model time delay contribution focused design algorithm digital control high order process approximated second order model time delay controller algorithms use digital modification linear quadratic smith predictor criterion combined pole assignment principle algorithms applied control set equal liquid cylinder atmospheric tanks
envelopes biaxial bending capacity reinforced concrete elements used extensively design structural safety evaluation verify adequacy internal force resultants series axial bending moments loading pairs computed prescribed load combinations however existing methods construct pmm interaction curves appropriate concrete hydraulic structures pressurized water could penetrate cracks leading coupled hydromechanical problem structural performance assessed using several criteria related allowable cracked area well allowable compressive tensile stresses usual unusual extreme load combinations paper presents methodology construct pmm interaction curves arbitrary cross sections hydraulic structures considering multiperformance criteria water penetration cracks well presence reinforcing steel computations based robust efficient isogonic approach based strength materials position neutral axis systematically varied cross section find pmm equilibrium solutions four application examples proposed approach presented illustrate versatility validate results show convergence properties cases pmm capacity envelopes formed distinct closed surfaces equilibrium solutions possible type pmm capacity envelope proposed algorithm able construct found classical reinforced concrete elements
work equation motion cantilever beam two piezoelectric patches one acting sensor actuator first formulated sensor induced voltage representing strain beam calculated beam governing equation converted state space model response active vibration control studied numerical simulations two types control methods used velocity feedback control vfc linear quadratic regulator lqr effects varying controller gains weighting matrices beam vibration amplitude settling time well induced voltage actuator investigated lqr controller found effective vfc maximum induced actuator voltage significantly lower lqr controller weighting matrices found increasing reduces settling time increases actuator induced voltage increasing increases settling time calculation method optimizing sensor placement actuator length also presented results indicate optimal actuator length beam length
relationship sustainability tourists complex little increase number studies published recent years focusing concept pro sustainable tourists tourist willingness pay wtp sustainability making increasingly difficult identify key explanatory factors determine tourists wtp sustainable destinations provide richer understanding tourists heterogeneous preferences sustainable destinations study allows determine current tourists attitude toward sustainability identify explanatory variables influence wtp enjoy sustainable destination study surveyed tourists western costa del sol spain mature sun sand destination currently restructuring facing several developmental challenges associated sustainability
assisting control vehicle speed driving downhill improves vehicle safety reduces driver workload internal combustion engine vehicles hybrid electric vehicles current technology widely used internal combustion engine vehicles hill descent control system however hill descent control achieved lower speeds may also lead thermal wear brake components prolonged intensive braking currently effective downhill safety assistance control technology hybrid electric vehicles effective across full range speeds take advantage regenerative braking address limitations previous studies novel downhill safety assistant control strategy hybrid electric vehicles adapts characteristics different drivers takes advantage braking subsystems hybrid electric vehicles proposed paper improve vehicle safety fuel economy ride comfort full range speeds adapt characteristics different drivers downhill driver intention model established basis statistical data analysis questionnaires experiments used determine control mode switching conditions control objective downhill safety assistant control improve vehicle safety fuel economy ride comfort full speed range coordinated control strategy electric motor braking subsystem engine braking subsystem hydraulic braking subsystem developed includes six braking assistant modes identifying strategy torque control electric motor based coordinated control strategies simulations experimental results show proposed control strategy improves vehicle safety fuel economy ride comfort hybrid electric vehicles downhill driving
power consumption high density communication equipment data centers exceedingly increasing internet traffic making huge impact environment cooling energy related cost projected dominant economical factor data centers near future energy efficient high speed communication systems required lower overall carbon foot print data centers traditional intensity modulation direct detection systems using multi mode fiber expected replaced spectral efficient coherent modulation formats single mode fiber conventional digital coherent receivers used long haul links dominates power budget communication system due huge amount power consumed analog digital converters numerous parallel interconnects hence may suitable short reach applications power consumption receiver reduced considerably processing received signals analog domain paper propose short reach optical interconnect scaled terabit second capacity proposed system uses super channel concept maximizing bandwidth utilization analog coherent receivers drastically reducing power consumption
background smoking highly prevalent among people experience severe mental ill health contributing poor physical health despite culture smoking mental health services people severe mental ill health often express desire quit smoking however services currently available aid quitting widely available general population may suitable effective people severe mental ill health aim study explore effectiveness cost effectiveness bespoke smoking cessation intervention specifically targeted people severe mental ill health methods design scimitar multicentre pragmatic two arm parallel group individually randomised controlled trial aim recruit participants aged years documented diagnosis bipolar disorder schizophrenia schizoaffective disorder smoke potentially eligible participants identified primary secondary care screened baseline data collected eligible consenting participants randomly allocated one two groups intervention arm participant assigned mental health professional trained deliver smoking cessation interventions work participant participant mental health specialist provide individually tailored smoking cessation service comparator arm usual care following current nice guidelines smoking cessation line general guidance offered smokers specific adaptation enhancement relation severe mental ill health primary outcome self reported smoking cessation months verified expired carbon monoxide measurement secondary outcome measures include body mass index months fagerstrom test nicotine dependence motivation quit questionnaire phq gad health service utilisation months economic evaluation months conducted form incremental cost effectiveness analysis discussion scimitar trial largest trial knowledge investigate effectiveness bespoke smoking cessation service people severe mental ill health
introduce modified simplified version pre existing fully parallelized three dimensional navier stokes flow solver known tpls demonstrate simplified version used pedagogical tool study computational fluid dynamics cfds parallel computing tpls heart two phase flow solver uses calls range external libraries accelerate performance however present context narrow focus study basic hydrodynamics parallel computing techniques code therefore simplified modified simulate pressure driven single phase flow channel using relatively simple fortran code mpi parallelization calls external libraries modified code analysed order validate accuracy investigate scalability cpu cores simulations performed several benchmark cases pressure driven channel flow including turbulent simulation wherein turbulence incorporated via large eddy simulation technique work may use advanced undergraduate graduate students introductory study cfds also providing insight interested general aspects high performance computing
objectivesparents general influence children health health behavior however given dearth specific literature regarding knowledge level social cultural factors influencing hpv vaccination behaviors among cambodian american parent difficult develop effective evidence based public health hpv vaccination program therefore objectives study determine hpv vaccine uptakes among teenagers examine factors influencing hpv vaccine uptakes design samplea descriptive cross sectional survey design combination network targeted sampling methods used resultsca mothers completed health survey face face interviews either english khmer language girls vaccination rates boys awareness knowledge hpv among mothers low many believed daughters speak english educated knowledge health logistic regression analysis showed girls significantly higher odds vaccination mothers possessed higher level english reading ability greater awareness knowledge hpv conclusionsthe strikingly low rates hpv vaccination among girls boys underscore need improve vaccination outreach education uptake findings used develop targeted public health hpv vaccination programs cas reduce cervical cancer disparities
background although dopamine precursor dihydroxyphenylalanine dopa remains gold standard pharmacological therapy patients parkinson disease long term treatment drug known result several adverse effects including dopa induced dyskinesia lid recently group reported modified herbal remedy neuroprotective effects vitro vivo models thus present study investigated whether would synergistic effects dopa antidyskinetic effects caused dopa well methods effects dopa motor function expression levels substance enkephalin enk basal ganglia glutamate content motor cortex assessed using behavioral assays immunohistochemistry western blot analyses liquid chromatography tandem mass spectrometry mouse model induced methyl phenyl tetrahydropyridine mptp addition antidyskinetic effects pathological movements triggered dopa investigated testing abnormal involuntary movements aims measuring activations fosb camp dependent phosphor protein kda darpp extracellular signal regulated kinases erk camp response element binding creb protein striatum results synergistically improved motor function low dose dopa administered addition significantly reversed mptp induced lowering improved enk levels basal ganglia ameliorated abnormal reduction glutamate content motor cortex furthermore significantly lowered aims controlled abnormal levels striatal fosb pdarpp perk pcreb induced high dose dopa conclusions lowered effective dose dopa alleviated lid findings suggest may used adjunct therapy enhance efficacy dopa alleviate adverse effects patients
condition monitoring greatly reduce maintenance cost wind turbine paper new condition monitoring method based nonlinear state estimate technique wind turbine generator proposed technique used construct normal behavior model electrical generator temperature new improved memory matrix construction method adopted achieve better coverage generator normal operational space generator incipient failure indicated residuals model estimates measured generator temperature become significant moving window averaging used detect statistically significant changes residual mean value standard deviation effective manner parameters exceed predefined thresholds incipient failure flagged examples based data supervisory control data acquisition system wind farm located zhangjiakou northern china used validate approach examine sensitivity key factors influence performance approach demonstrated technique identify dangerous generator temperature damage occurred results complete shutdown turbine
limited research examined differences well established suicide correlates individuals various histories suicidality within ideation action framework hypothesized individuals without history elevated suicidality would exhibit lowest levels suicide correlates perceived burdensomeness thwarted belongingness emotion dysregulation depressive symptoms group differences would present history suicidal ideation relative history suicide attempts variables theorized contribute capability suicide lastly hypothesized prior history suicide attempt would exhibit higher levels lifetime painful provocative events fearlessness death relative history ideation community sample adults recruited part basis history suicidality completed self report questionnaires online results largely consistent hypotheses however differences fearlessness death history suicidal ideation history attempts many variables considered robust correlates suicide may directly relate suicidal ideation rather suicide attempts thereby limiting utility understanding transition ideation action elsevier ireland ltd rights reserved
disease progression eosinophilic esophagitis eoe childhood adulthood unclear determine clinical outcome patients diagnosed eoe children young adults children years old identified structured telephone interview conducted obtain follow data symptom prevalence dysphagia solids liquids nausea vomiting abdominal pain heartburn regurgitation food impaction medication usage health care utilization resolution atopy food allergies favorable outcome defined eoe symptoms resolved improved subjects assessment unfavorable outcomes defined symptoms worse clinical variables predicted favorable outcome adult examined mayo dysphagia scale mdq scored administered validate outcome assessment mantel haenszel odds ratio unpaired test used fifty eight subjects male met study criteria enrolled mean age diagnosis years range mean duration follow years children common presenting symptoms abdominal pain dysphagia vomiting young adults subjects favorable outcome total mdq scores subjects favorable outcome unfavorable outcome respectively two thirds subjects use steroids proton pump inhibitors preceeding months male children eoe four times likely favorable outcome young adults compared female children females likely report nausea vomiting young adults odds ratio presenting symptoms eoe children dysphagia likely persist adulthood odds ratio eighty one percent eoe children favorable outcome young adults patients symptom resolution require form steroid therapy seek healthcare
majority patients presenting allergic rhinitis asthma sensitised several allergens dust mites chief culprits two important species france dermatophagoides pteronyssinus dermatophagoides farinae studies indicate patients multi sensitised however important distinguish sensitisation allergy sensitisation exclusively biological phenomenon positive prick tests ige assays term allergy implies existence clinical symptoms detectable precise history taking management dust mite allergies based upon fastidious elimination offending source suitable symptomatically treatment allergy immunotherapy chiefly sublingual route slit successful elimination dust mites depends degree patient sensitisation extent exposure dust mites measures taken allergies domestic pollutants present removal difficult dust mites random case allergens pollens moulds cockroaches etc ait form treatment able modify immune status allergic individuals indicated cases poor control rhinitis asthma means global allergen removal systematic treatments multi allergic patients two sources allergens required may administered either parallel using two allergen preparations mixture using single preparation ait given parallel example dust mites grass pollens recommended interval minutes left two allergens ait performed using mixture allergens within single preparation recommended preparation made mixture mutually compatible allergen sources prescription multiple ait underlines importance dilution factor mixing several allergens reduces doses allergen keeping number components used slit currently reference pathway practically approach utilised children ease use well absence pain serious adverse effects must performed using high quality standardised allergen extracts particular attention clinical relevance allergens used safety use patient quality life elsevier masson sas rights reserved
purpose review genetic dyslipidemias contribute prevalence ischemic heart disease field genetic dyslipidemias influence atherosclerotic heart disease rapidly developing accumulating increasing evidence purpose review describe current state knowledge regard inherited atherogenic dyslipidemias disorders familial hypercholesterolemia elevated lipoprotein detailed genetic technology made rapid advancements leading new discoveries inherited atherogenic dyslipidemias explored review well description possible future developments increasing attention come upon genetic disorders familial hypercholesterolemia elevated lipoprotein recent findings review includes new knowledge disorders including description disorders method diagnosis prevalence genetic underpinnings effect development cardiovascular disease addition discusses major advances genetic technology including completion human genome sequence next generation sequencing genome wide association studies also discussed rare variant studies specific genetic mechanisms involved inherited dyslipidemias proprotein convertase subtilisin kexin type pcsk enzyme summary field genetics dyslipidemia cardiovascular disease rapidly growing result bright future novel mechanisms action new therapeutics
article intends describe influences different parenting styles development prosocial behaviors primary school children identify parenting style contributes develop purpose spanish english articles published last ten years selected found parents models children tend imitate parental style use exerts great influence facilitative inhibitory development prosocial behaviors within different parenting styles democratic style one would help develop kind behaviors
pollution produced power purchased electrical network extensive effort iranian government toward elimination energy subsides encouraging factors iran employing hybrid green power system hgps produce power therefore study effect current future energy prices well energy budget optimal design hgps studied three cases considered examine optimization problem thoroughly autonomous hgps nonautonomous hgps hgps sell electricity electrical network iii nonautonomous hgps hgps allowed sell electricity electrical network results case case show increase energy price three five times budgets cases respectively required ensure design economical
cloud computing recently emerged dominant internet service computing model due payas elastic service features cloud computing systems usually composed distributed datacenters leverage virtualization technology provide scalable reliable service optical networks recognized promising next generation core networks connecting distributed datacenters due characteristics high bandwidth provisioning low latency low bit error rate etc however concern ever increasing energy consumption cloud computing systems together core networks raised due high electricity bills well environmental pollution paper study energy aware provisioning optical cloud networks epocn problem dynamic static cases traffic requests arrive online fashion propose polynomial time energy aware routing algorithm solve dynamic epocn problem simulations show energy aware routing algorithm brings energy savings comparison shortest path based routing algorithm traffic grooming algorithm hand show epocn problem static case traffic matrix known advance hard divide problem energy aware routing ear problem optical networks energy efficient server switch allocation essa problem datacenter networks considering two sub problems still hard present exact integer linear program ilp heuristic solve problem also conduct simulations compare proposed ilps heuristics terms energy consumption running time elsevier rights reserved
objectives evaluate prevalence clinical correlates metabolic syndrome mets components among patients psychiatric disorders methods cross sectional study conducted among adult patients psychiatric disorders major hospitals saudi arabia measurements recorded mets components demographic clinical information obtained mainly reviewing patients medical charts results prevalence rate mets among study participants high triglycerides large waist circumference high blood pressure high fasting blood sugar low hdl cholesterol participants mets likely older illiterate divorced widowed higher number children older age onset psychiatric illness longer duration psychiatric disease previous psychiatric hospitalization history diabetes hypertension adjusting significant demographic clinical characteristics none psychiatric diagnoses treatments independently associated mets except use mirtazapine venlafaxine conclusions prevalence mets components among patients psychiatric disorders alarming irrespective diagnoses thus metabolic screening especially among high risk groups critical authors published elsevier inc
shown recently proposed modified current feedback operational amplifier mcfoa quite versatile element given realization system function using mcfoas obtain three alternate realizations using mcfoa appropriately connecting terminals mcfoa remaining part original realization using results concerning transpose multi terminal element shown transpose mcfoa another mcfoa thus using results transposition given voltage mode circuit using mcfoas directly obtain four current mode circuits using mcfoas vice versa copyright john wiley sons ltd
majority rfid authentication scenarios involve single tag identified independent tags field reader however situations necessitate simultaneous authentication multiple tags well verification simultaneous physical proximity reader duels introduced yoking proof simultaneous authentication multiple rfid tags several researchers since developed variants yoking proof using symmetric asymmetric cryptography given ambient conditions bound similar objects close physical proximity one another critically evaluate use various relevant ambient conditions purpose based evaluation choose use tag temperature develop variant yoking proof protocol simultaneous authentication multiple tags elsevier rights reserved
background evidence shows negative impact irritable bowel syndrome quality life patients suffer condition compared general population objective objective study determine health related quality life adults irritable bowel syndrome receiving treatment specialist hospital material methods study cross sectional prospective design study included consecutive patients diagnosed irritable bowel syndrome rome iii criteria attending outpatient appointments questionnaire applied standard spanish version results compared population reference scores mexico statistical analysis performed student test analysis variance chi squared test considering significance results one hundred fifty four patients included study women men average age constipation diarrhea mixed subtypes comprised patients respectively quality life patients irritable bowel syndrome population reference scores mexico physical health sub scale mental health sub scale respectively significant difference found quality life among irritable bowel syndrome subtypes conclusions health related quality life lower patients irritable bowel syndrome population north east mexico compared data taken population reference study undertaken country enabling inference female population cautious one results found small male sample studied significant difference found quality life according clinical subtype irritable bowel syndrome
environmental factors determinant appearance autoimmune thyroid diseases aitd susceptible subjects increased iodine intake selenium vitamin deficiency exposure radiation nuclear fallout due medical radiation environmental factors increasing aitd cigarette smoking associated graves disease graves ophthalmopathy decreases risk hypothyroidism thyroid autoimmunity viral infections important environmental factors pathogenesis aitd particularly human parvovirus evb hepatitis virus among many chemical contaminants halogenated organochlorines pesticides variably disrupt thyroid function polychlorinated biphenyls metabolites polybrominated diethyl ethers bind thyroid transport proteins transthyretin displace thyroxine disrupt thyroid function among drugs interferon iodine containing drugs associated aitd moreover intestinal dysbiosis causes autoimmune thyroiditis reduce risk populations also patient necessary comprehend association environmental agents thyroid dysfunction
african american men significantly higher mortality rates prostate cancer prca racial groups therefore critical need identify strategies promoting informed prca screening decisions among population article details community driven social behavioral research implemented statewide cancer prevention control program cpcp support development person person technological interventions improve dissemination prca information men families article concludes four recommendations advance future research practice related use interventions promoting informed prca decision making among aas recommendations include informing men controversial screening recommendations including families educational interventions prca using technology modality disseminating prca information appropriate aiming create interventions translated community clinical settings
background myocardial infarction nonobstructive coronary arteries minoca occurs patients myocardial infarction clinical trials secondary prevention treatment minoca patients lacking therefore aim study examine associations treatment statins renin angiotensin system blockers beta blockers dual antiplatelet therapy long term cardiovascular events methods observational study minoca patients recorded swedeheart registry swedish web system enhancement development evidence based care heart disease evaluated according recommended therapy july june followed december outcome events swedish cause death register national patient register myocardial infarction admissions consecutive unique patients minoca identified among patients surviving first days discharge constituted study population mean age years women patient lost follow stratified propensity score analysis performed match treated untreated groups association treatment outcome estimated comparing treated untreated groups using cox proportional hazards models exposures treatment discharge statins angiotensin converting enzyme inhibitors angiotensin receptor blockers beta blockers dual antiplatelet therapy primary end point major adverse cardiac events defined cause mortality hospitalization myocardial infarction ischemic stroke heart failure results discharge patients statins angiotensin converting enzyme inhibitors angiotensin receptor blockers beta blockers dual antiplatelet therapy respectively follow mean years patients experienced major adverse cardiac event hazard ratios confidence intervals major adverse cardiac events patients statins angiotensin converting enzyme inhibitors angiotensin receptor blockers beta blockers respectively patients dual antiplatelet therapy followed year hazard ratio conclusions results indicate long term beneficial effects treatment statins angiotensin converting enzyme inhibitors angiotensin receptor blockers outcome patients minoca trend toward positive effect beta blocker treatment neutral effect dual antiplatelet therapy properly powered randomized clinical trials confirm results warranted
issues political parties emphasize campaigns selecting issues emphasize campaigns treated importance policy positioning nevertheless little attention paid understanding parties strategies issue competition presidential elections multiparty systems analyzing statements presidential candidates korean presidential debates find presidential candidates use issue emphasis strategies differently presidential elections according party size ideological relationships parties specifically small party candidates likely mainstream parties candidates pursue issue ownership advantage addition mainstream party candidates emphasized issues small party party two parties similar ideological foundation whereas ideological similarities mainstream party candidate focused issues mainstream party results imply political communication used political parties candidates conditioned political contexts electoral systems party systems also size ideology parties
human immunodeficiency virus hiv enters brain soon seroconversion induces chronic neuroinflammation infecting activating brain macrophages inflammasomes cytosolic protein complexes mediate caspase activation ensuing cleavage release beta macrophages group recently showed hiv infection human microglia induced inflammasome activation nlrp dependent manner hiv viral protein vpr accessory protein released hiv infected cells although effects neuroinflammation undefined infection human microglia vpr deficient hiv resulted reduced caspase activation beta production compared cells infected vpr encoding hiv virus vpr detected low nanomolar concentrations cerebrospinal fluid hiv infected patients supernatants hiv infected primary human microglia exposure human macrophages vpr caused caspase cleavage beta release reduced cell viability dependent nlrp expression increased nlrp caspase beta expression evident hiv vpr transgenic mice compared wild type littermates following systemic immune stimulation treatment caspase inhibitor suppressed nlrp expression reduced beta expression associated neuroinflammation neurobehavioral deficits showed improvement vpr transgenic animals treated thus vpr induced nlrp inflammasome activation contributed neuroinflammation abrogated caspase inhibition study provides new therapeutic perspective hiv associated neuropsychiatric disease
models useful tool increase developer productivity satisfaction performing maintenance tasks however order maximise advantages right selection notations must made unfortunately software engineering field lacks body empirical evidence supports selection suboptimal decision regard may negative consequences maintenance process aim study compare textual graphical notation respect efficiency effectiveness satisfaction junior software developers performing analysability modifiability tasks two different applications carried quasi experiment third year students computer engineering degree university alicante subjects randomly classified two groups group performed maintenance tasks textual graphical notation measured compared efficiency effectiveness satisfaction subjects assigned treatment analysed data show actual analysability coverage aacov actual modifiability efficiency ameffc affected type notation used regardless application cases subjects using textual notation performed significantly better although effect size low moderate aacov ameffc pilot study conducted enhance design future studies area thus replicated extend conclusions subject profiles different textual graphical notations application types
background assess thyroid function group women first trimester pregnancy reside geographic area moderate iodine deficiency assess usefulness early pregnancy screening methods study population included women first trimester pregnancy residing valley appenine mountains casentino tuscany characterized known moderate iodine deficiency tsh urinary iodine level anti thyroid peroxidase autoantibodies anti tpo antibodies added tests included regional prescription pad first blood draw data thyroid disease use iodized salt also recorded results women examined tsh value mui urinary iodine level found women median urinary iodine level women using iodized salt women using significant statistical difference none women included study taking iodine containing supplements conclusions area known moderate iodine deficiency women presented tsh values mui women presented urinary iodine deficiency first trimester pregnancy makes case thyroid function screening strengthening iodine supplementation beginning pregnancy
background psoriatic arthritis psa inflammatory musculoskeletal disease develops approximately patients psoriasis previously chemokine motif ligand cxcl identified predictive biomarker psa patients psoriasis reduced development psa purpose present study explore messenger rna mrna protein expression cxcl receptor chemokine motif receptor cxcr joints patients psa gain insight role pathogenesis disease methods sera patients psa healthy control subjects compared expression cxcl luminex assay synovial fluid obtained patients psa osteoarthritis gout rheumatoid arthritis clinical care mrna protein expression cxcl interleukin cxcr tbx rorc interferon ifn gamma compared among mentioned disease groups well paired serum samples patients psa using real time polymerase chain reaction luminex assays respectively results serum cxcl significantly higher patients psa control subjects cxcl tbx expression elevated cells patients psa compared patients gout patients cxcr rorc elevated psa cells compared patient groups concordant results obtained cxcl protein expression ifn gamma elevated psa compared cxcl protein expression substantially increased median interquartile range iqr compared paired serum samples median iqr whereas ifn gamma significantly reduced median iqr versus serum median iqr conclusions cxcl may important etiological role psa analogous candidate biomarker distinguish psa healthy individuals patients gout
background exact determination children sleep habits growth could help prevent risk factor children growth disorders thus research performed investigate correlation sleep habits growth preschool children ahvaz iran materials methods cross sectional study data obtained using available sampling children years old came private pediatric clinic ahvaz south west iran without regard gender measurement height weight patients meter scale performed measuring height weight stature age weight age percentiles calculated using child growth chart calculator cdc child information onset time night sleep time wake morning nap duration children gathered using researcher made questionnaire data analysis performed descriptive statistic kendall tau statistical test using spss results results study showed children evaluated stunted underweight growth disorder results kendall tau test showed significant relationship onset time night sleep waking time morning nap duration neither height age percentile weight age percentile preschool children conclusion results study showed children sleep habits affect stature weight percentile mean going sleep late effect children health since establishment normal sleep wake rhythm essential physical mental development children necessary educate parents regarding importance children sleep
help symbolic computation benjamin bona mahony bbm equation variable coefficients presented proposed first time benjamin regularized long wave equation originally derived approximation surface water waves uniform channel employing improved expansion method truncated painleve expansion method derive new auto backlund transformation hyperbolic solutions variety traveling wave solutions soliton type solutions two solitary wave solutions bbm equation obtained solutions possess abundant structures figures corresponding solutions illustrated show particular localized excitations interactions two solitary waves
demonstrate usage industrially produced zeolites adsorption ionic liquids ils water using butyl methylimidazolium chloride bmimcl representative land nay typical type zeolite adsorption behaviors bmimcl nay characterized adsorption kinetics isotherms thermodynamics interferences compounds pseudo order satisfactorily describes adsorption kinetics thus langmuir isotherm shown suitable model interpreting isotherm data corresponding max nay bmimcl higher many reported carbonaceous bio derived adsorbents attributed electrostatic attraction negatively charged nay cationic bmim ions adsorption bmimcl nay favorable stable neutral alkaline conditions whereas ions ionic surfactants significantly interfere adsorption addition solvent washing methods less effective approaches regeneration whereas used nay fully gain adsorption capacity heat treatment adsorption isotherms mim based nay also determined show nay readily available industrial material effective adsorbent bmimcl behaviors revealed valuable critical investigating adsorptive removal ils water interaction zeolites water elsevier rights reserved
buoyancy dexterity robustness internet technologies given rise field online experimentation advantages placing laboratories online fuelled development new sphere laboratory work lot research going global set experiments available internet grows shortage online introductory experiments field control system engineering focus study expand set online experiments control engineering field familiarizing users control system paper development control experiments using lab interactive architecture presented study design develop graphic user interface guis using labview ease students performing position control speed control system modeling servomotor experiments platform platform implemented online using massachusetts institute technology interactive laboratory architecture scope project apply virtual instruments implement proportional integral derivative controller position control speed control modeling control system controller used control output response stabilize control system interactive software developed help students visualize analyze system
tuberculosis exceeds hiv top infectious disease cause mortality caused mycobacterium tuberculosis complex mtbc mtbc strains highly conserved genome sequences similarity dramatically different phenotypes analyze relationship genotype phenotype conducted comparative genomic analysis mtbc strains representing different lineages mycobacterium bovis bovis bcg microti africanum tuberculosis hrv tuberculosis hra six tuberculosis clinical isolates analysis focused three aspects pathogenicity host association virulence epitope variations host association analysis indicated eight mce genes two enoyl coa hydratases five ppe family genes present human isolates may roles host pathogen interactions snps found virulence factors including five snps three esx secretion proteins beijing strains might related virulent phenotype comparison virulent hrv non virulent hra strains revealed three snps likely associated virulence attenuation hra phop mazg newly identified espk additionally comparison animal associated mtbc strains showed deletion first four genes ppe esxb esxa rather eight genes might play central role virulence attenuation animal isolates finally comparing epitopes among mtbc strains found four epitopes lost beijing strains may render better capable evading human immune system leading enhanced virulence overall comparative genomic analysis mtbc strains reveals relationship highly conserved genotypes diverse phenotypes mtbc provides insight pathogenic mechanisms facilitates development potential molecular targets prevention treatment tuberculosis
treatment articular extra articular manifestations associated hla undergone dramatic changes past two decades mainly consequence introduction biologic agents particular anti tumor necrosis factor anti tnf alpha agents uveitis known frequent extra articular feature hla associated spondyloarthritides topical corticosteroids cycloplegic agents remain cornerstones treatment however biologic therapy may effective management refractory recurrent forms uveitis review gives update management hla associated ocular disorders biologics including anti tnf alpha agents non anti tnf alpha biologic modifier drugs emerging role newer biologics targeting interleukin interleukin treatment spondyloarthritides data efficacy anterior uveitis sparse
wavelet transformation based fuzzy reflex control method proposed prevent slip maintain stable grasping posture prosthetic hands key component control method response time slip detection slip prevention short proposed control method mainly includes slip detection reflex grasping force estimation use reflex controller slip detection initial slip information rapidly obtained via wavelet transformation soon disturbances cause grasped object slip shortens response time reflex control initial slip information trigger reflex control grasping estimation reflex force estimation model presented estimate force increment used adjust desired force reflex controller fuzzy logic controller adopted track desired force finally proposed control method applied control prosthetic hand single degree freedom experimental results show proposed control method adjust grasping force effectively prevent slip disturbances time slip prevention less
conclusion patients bppv experienced short intense anxiety panic disorder especially initial visit patients recovered without medication successful treatment objective recent studies shown people dizziness report psychological problems panic agoraphobia anxiety aim study evaluate anxiety panic agorophobia levels patients benign paroxysmal positional vertigo initial presentation follow visit compare scores control group methods patients study diagnosis bppv confirmed history typical subjective symptom reports characteristic positional nystagmus dix hallpike test roll test patients instructed complete standard forms beck anxiety inventory panic agoraphobia scale questionnaire days canalith repositioning treatment results validity scores panic agoraphobia statistically significantly higher patients bppv control group period validity scores beck anxiety inventory statistically significantly higher patients bppv control group first second evaluation
micrornas mirnas mrnas establish complex regulatory network influencing diverse biological pathways including muscle development growth elucidating mirna dependent regulatory networks involved muscle development could provide additional insights muscle traits largely predefined prenatal development present study aimed determine differentially expressed transcripts functional mirna mrna relationships associated different stages skeletal muscle development two pig breeds german landrace pietrain distinct muscle characteristics comparative transcriptional profiling longissimus dorsi muscle tissues fetuses days post conception well adult pigs days postnatum performed using affymetrix genechip porcine genome microarray differential expression patterns identified associated muscularly developmental stages breed types integration mirna expression data ingenuity pathways analysis ipa pathway analysis revealed several mirna dependent regulatory networks related muscle growth development present results provide insights muscle biology improvement porcine meat quality
developed countries public health systems pressure due increasing percentage population context homecare based ambient intelligence technology seems suitable solution allow elderly people continue enjoy comforts home help optimize medical resources thus current technological developments make possible build complex homecare applications demand among others flexibility mechanisms able evolve context adaptability well avoiding service disruptions case node failure availability solution proposed paper copes flexibility requirements whole life cycle target applications design phase runtime proposed domain modeling approach allows medical staff design customized applications taking account adaptability needs also guides software developers system implementation application execution managed multi agent based middleware making possible meet adaptation requirements assuring time availability system even stateful applications
investigated whether black white biracial individuals perceived black domain evaluation previous research documented white perceivers negative evaluation one black person leads negative implicit evaluation another black person belonging minimal group built upon group transfer effect investigating whether perceivers also transferred negative implicit attitudes one black person novel black white biracial person three experiments participants learned black individual performed undesirable behaviors introduced new group member white perceivers formed negative attitudes toward original individual transferred attitudes new group member black biracial white experiment asian experiment experiment demonstrated white participants exhibited transfer new black biracial group members black participants
architecture access control system user jobs access computational resources grid distributed computing networks provides protection data processed threats exceeding user privileges presented developed system compared available analogues results efficiency assessment performance developed system discussed
context enigma agile projects succeed without requirements weak requirements engineering known cause project failures agile development projects often manage well without extensive requirements test cases commonly viewed requirements detailed requirements documented test cases objective investigated agile practice using test cases requirements understand test cases support main requirements activities practice varies method performed iterative case study three companies collected data interviews two focus groups results use test cases requirements poses benefits challenges eliciting validating verifying managing requirements used documented agreement identified five variants test cases requirements practice namely facto behaviour driven story test driven stand alone strict stand alone manual application practice varies concerning time frame requirements documentation requirements format extent test cases machine executable specification use tools provide specific support practice using test cases requirements conclusions findings provide empirical insight agile development projects manage communicate requirements identified variants practice using test cases requirements used perform depth investigations agile requirements engineering practitioners use provided recommendations guide designing improving agile requirements practices based project characteristics number stakeholders rate change elsevier rights reserved
measured psychopathy checklist revised pcl psychopathy dimensional construct underpinned correlated factors interpersonal affective lifestyle antisocial theorists clinicians karpman arieti posited variants primary true psychopathy distinct called secondary pseudopsychopathy used latent profile analysis determine homogeneous classes exist within sample male offenders high pcl scores pcl factors dependent variables clustering solution latent classes showed better fit data unitary model without latent classes tentative labels latent classes manipulative latent class aggressive latent class sociopathic latent class latter class represented antisocial group lacked emotional detachment observed groups propose reflect phenotypic variations theme traditional construct psychopathy consistent conceptions antisocial personality disorder sociopathy replication external classification independent data set adult male offenders yielded clearly separable clusters well meaningful differences trends among latent classes education intelligence symptoms antisocial personality disorder self reported psychopathic traits negative affect conceptualization psychopathy terms manipulative aggressive variants consistent clinical theory empirically grounded
monitoring measuring structural behavior advanced recently many researchers studied structural health monitoring using gnss global navigation satellite system paper presents temperature behavior gwang bridge three span suspension bridge korea behavior middle span analyzed ambient temperature change time passed january june vertical displacement decreased temperature increased middle span correlation analysis performed temperature vertical displacement using thermometer gnss also monthly changes temperature natural frequency measured correlation analysis performed temperature natural frequency result evaluation regarding thermal effect middle span relationship temperature natural frequency seemed trend inverse proportion
background symptoms description often enough provide clinicians guidelines treatments patients clinical history represent exhaustive source data psychopathological dysfunctions known relate core disturbances underlie different forms psychopathology identification dysfunctions could helpful treatments tools available although highly complex lengthy study aimed provide clinicians easy administer instrument able capture different levels impairment psychopathological functioning namely psychopathological functioning levels rating scale pfl methods psychopathological functioning level research training committee pfl rtc established turin since including psychiatrists clinical psychologists extensive clinical research experience research grounded qualitative research criteria qrc conducted subsequent steps order identify core psychopathological dysfunctions rated tool results outpatients administered clinical interview least two different occasions diagnoses mixed included schizophrenic psychotic disorders depressive disorders anxiety disorders obsessive compulsive disorder post traumatic stress disorder somatic symptoms disorders eating disorders personality disorders focus groups conducted identify psychopathological dysfunctions needed rated according two phenomenological selection criteria phsc four etiopathogenetic selection criteria etsc result five dysfunctional areas emerged identity comprehension negative emotions action regulation social skills checking dimensions consistency existing instruments levels severity identified area finally provisional italian schedule psychopathological functioning levels rating scale pfl obtained checked semantic comprehension administered gathering preliminary data conclusions psychopathological dysfunctions underlying mental disorders recognized present study pfl instrument seems promising inform specific way treatments strategies goals specifically concerning psychotherapy notwithstanding research needed order confirm validity sensitivity reliability instrument
increasing amount interconnections vehicles attack surface internal vehicle networks rising steeply although networks shielded external attacks often internal security protect malicious components adversaries breach network perimeter secure vehicle network communicating components must authenticated authorized components allowed send receive messages achieved use authentication framework cryptography widely used authenticate communicating parties provide secure communication channels internet communication however real time performance requirements vehicle networks restrict types cryptographic algorithms protocols may used particular asymmetric cryptography computationally infeasible vehicle operation work address challenges designing authentication protocols automotive systems present lightweight authentication secure automotive networks lasan full lifecycle authentication approach describe core lasan protocols show protect internal vehicle network complying real time constraints low computational resources domain lever aging fixed structure automotive networks minimize bandwidth computation requirements unlike previous work also explain framework integrated aspects automotive product lifecycle including manufacturing vehicle maintenance software updates evaluate lasan two different ways first analyze security properties protocols using established protocol verification techniques based formal methods second evaluate timing requirements lasan compare frameworks using new highly modular discrete event simulator vehicle networks developed evaluation
problem vector equalization based recurrent neural networks suboptimum scheme considered analog signal processing point view distinguish discrete time recurrent neural networks dtrnns continuous time ones ctrnns contrast ctrnns dtrnns extensively investigated implemented vector equalization task good results channels little moderate interference however growing demand jointly high date rates power efficiency green communications make analog signal processing interesting topic field wireless transmission analog signal processing possesses potential fast power efficient compared digital signal processing techniques addition large scale integration vlsi technology shown fit well implementation medium neural networks facts motivate investigation ctrnns vector equalizer show paper computer simulations circuit simulations progress
chemotherapy reliable treatment osteoporosis osseous metastases facilitate better drug delivery bone treatments novel preparation polymeric nanoparticles high affinity bone prepared two step synthesis cholesteryl functionalized poly ethylene sodium phosphate pepn center dot performed via ring opening polymerization cyclic phosphoesters demethylation molecular weight pepn center dot could well controlled changing ratio cholesterol cyclic phosphoesters pepn center dot exhibits amphiphilic nature aqueous media pep bearing nanoparticles pep nps prepared solvent evaporation technique size nanoparticles investigated current study approximately determined dynamic light scattering dls transmission electron microscopy tem due presence highly water soluble polymer chains dispersion pepn center dot nps aqueous media stable least week hemolytic activity pepn center dot nps found low pepirna nps disintegrate mammalian cell membranes additionally cytotoxicity pepn center dot nps observed concentrations adsorption pepn nps hydroxyapatite hap microparticles studied comparison poly ethylene glycol nanoparticles peg nps pepn center dot nps peg nps adsorbed well onto hap microparticles distilled water binding equilibrium constants ichap pepn center dot nps peg nps respectively contrast pepn center dot nps adsorbed onto hap microparticles saline phosphate buffer moreover adsorption pepn center dot nps onto hap microparticles occurred even presence calcium ions low media affinity nanoparticles bovine bone slices also studied result large quantities adsorbed pepn center dot nps observed slices scanning electron microscope elsevier rights reserved
forkhead transcription factor foxoa reported ambiguous functions distinct mechanisms various solid tumors including glioblastoma gbm although preliminary analysis small sample patients indicated foxoa aberrations glioma might related aggressive clinical behavior clinical significance foxoa glioblastoma remains unclear investigated expression foxoa cohort glioblastoma specimens analyzed correlations protein expression patient prognosis furthermore functional impact foxoa gbm progression underlying mechanisms foxoa regulation explored series vitro vivo assays foxoa expression elevated glioblastoma tissues high nuclear foxoa expression human gbm tissues associated poor prognosis moreover knockdown foxoa significantly reduced colony formation invasion ability gbm cells whereas overexpression foxoa promoted colony formation invasion ability results vivo gbm models confirmed foxoa knockdown inhibited gbm progression pro oncogenic effects foxoa gbm mediated activation myc microtubule associated protein light chain beta lcb beclin mixed lineage leukemia mll dependent manner findings suggest high foxoa expression associated glioblastoma progression foxoa independently indicates poor prognosis patients foxoa might novel prognostic biomarker potential therapeutic target glioblastoma new genetic aberrations forkhead transcription factor foxoa thought play role aggressive glioblastoma gbm though nature involvement remains unclear study high foxoa expression positively correlated gbm progression poor prognosis patients cells foxoa found promote gbm progression via activation myc autophagy related proteins lcb beclin foxoa pro oncogenic effects mediated epigenetic factor mll addition mice foxoa knockdown inhibited gbm progression findings suggest foxoa potential prognostic biomarker therapeutic target gbm
background prevalence childhood trauma elevated among individuals severe mental illness smi compared general population associated poor prognosis substance misuse lower treatment compliance violence antisocial personality disorder aspd typologies childhood adult onset also represent possible mediating mechanisms explain risk violence among men smi current study aimed explore explanatory pathway linking childhood traumatic exposure antisocial personality typologies risk violent behaviour among adult male inpatients smi methods total male inpatients smi examined using cross sectional survey design information extracted medical files interviews official criminal records results fifty two participants reported experiencing childhood trauma group times likely engage violent acts within past months without history furthermore childhood onset aspd early starters likely report childhood trauma engage violence compared adult onset aspd late starters without antisocial histories multivariate analyses revealed early starter aspd variable independently predicted violence mediated relationship childhood trauma recent violent acts conclusions significant subset men reporting trauma antisocial conduct childhood early starter aspd considerably elevated risk engaging violent behaviours assessment antisocial typologies men smi may assist effective defensible case prioritisation resource allocation treatment planning elsevier rights reserved
purpose game based learning used successfully areas formal education construction management increased uptake games teaching learning focusing bidding game purpose paper evaluate ability enhancing students learning specific objectives examine effectiveness game teaching mechanism explore students learning experience preference motivation participate game identify relationship game features students learning experience overall satisfaction design methodology approach paper adopted survey research design questionnaire survey conducted two universities australia involving students gameplay findings results show overall student feedback positive vast majority students enjoying learning experience students institutions indicated preference group based game sessions however students divergent opinions game incentive motivation found significant correlations game features students learning experience overall satisfaction practical implications bidding game clearly potential adaptation construction bidding related courses educators could consider incorporating significant game features towards improving students learning experience overall satisfaction originality value given limited studies aimed evaluating educational games student feedback research facilitate critical reflective process incorporating similar form games teaching construction management bidding related courses
flexural vibration analysis beams made functionally graded materials fgms various boundary conditions considered paper due technical problems fgm fabrication porosities micro voids created inside fgm samples may lead reduction density strength materials investigation fgm beams assumed even uneven distributions porosities beam cross section modified rule mixture used approximate material properties fgm beams including porosity volume fraction order cover effects shear deformation axial rotary inertia timoshenko beam theory used form coupled equations motion describing dynamic behavior beams solve problem chebyshev collocation method employed find natural frequencies beams supported different end conditions based numerical results revealed fgm beams even distribution porosities significant impact natural frequencies fgm beams uneven porosity distribution
aim nrg erbb neurotransmitter signaling pathway plays key role pathogenesis schizophrenia intronic single nucleotide polymorphism erbb links pik akt suppression another protein indirectly affecting nrg erbb signaling beta secretase encoded bace gene activates nrg proteolytic cleavage study aimed investigate association erbb bace risk iranian population subjects methods total subjects including patients healthy controls matched ethnicity age gender recruited case control study genomic dna extracted peripheral blood subjects genotyping performed using polymerase chain reaction pcr restriction fragment length polymorphism tetra primer amplification refractory mutation system tetra arms pcr genotyping assays respectively results significant association observed allele odds ratio confidence interval association risk conclusion data indicate associated risk silico analysis indicates may potential splicing site affects protein structure replication studies needed confirm data
objective proposed work investigate performance hybrid self tuned fuzzy proportional integral derivative stfpid controller brushless bldc motor drive proposed hybrid stfpid controller includes proportional integral derivative pid controller steady state pid type self tuned fuzzy logic controller stflc transient state thereby combining merits controllers switching function incorporated controller ensures desired control response various operating conditions appropriately switching pid stfpid based speed error detailed simulation study performance comparison control approaches performed highlight merits proposed work simulation results indicate proposed controller robust fast tracking capability less steady state error experimental results provided validate simulation study
aims objectivesto examine cost effectiveness semi rigid ankle brace facilitate return work following first time acute ankle sprains designeconomic evaluation based cost utility analysis backgroundankle sprains source morbidity absenteeism work accounting sports injuries semi rigid ankle brace taping functional treatment interventions used musculoskeletal physiotherapists nurses facilitate return work following acute ankle sprains methodsa decision model analysis based cost utility analysis perspective national health service used primary outcomes measure incremental cost effectiveness ratio based quality adjusted life years costs quality life data derived published literature model clinical probabilities sourced musculoskeletal physiotherapists resultsthe cost quality adjusted life years gained using semi rigid ankle brace respectively however cost quality adjusted life years gained following taping respectively incremental cost effectiveness ratio semi rigid brace pound per quality adjusted life year probabilistic sensitivity analysis showed ankle brace provided highest net benefit hence preferred option conclusiontaping cheaper intervention compared ankle brace facilitate return work following first time ankle sprains however incremental cost effectiveness ratio observed ankle brace less national institute health care excellence threshold intervention higher net benefit suggesting cost effective intervention decision makers may willing pay pound additional gain quality adjusted life year relevance clinical practicethe findings economic evaluation provide justification use semi rigid ankle brace musculoskeletal physiotherapists nurses facilitate return work individuals first time ankle sprains
paper mainly suggested methods find minimal negatively transitive closures fuzzy relation finite universe based construction proposed han time example given illustrate methods computer programming result minimal negatively transitive closures differing han obtained
background coping skills enable caregivers establish maintain supportive relationships haemodialysis patients care skills important terms social support promotion mental health social family relations aim study investigate coping skills iranian family caregivers take care patients undergoing haemodialysis methods twenty participants selected study purposive sampling data gathering techniques used research depth unstructured interviews researchers used inductive thematic analysis approach analyse data generated interviews results four main themes emerged data help seeking skills self nurturing skills time management skills stress management skills conclusion focus attention stress management coping skills caregivers haemodialysis patients together ability cope complex problems healthcare providers taking account skills strategies empowerment help caregivers haemodialysis patients cope heavy care conditions better define purposes caretaking
work aims identifying extent incidence bullying harassment furthermore help understand offensive nature action identify prevention measures helping victims youth basketball teams suggests organisational individual preventive measures limit possible attack help victims identify available assistance resources order expand scientific literature area study wishes broaden field bullying harassment research include school teen sports activities potential professional athletes quantitative analysis method selected using developed questionnaire distinguished bullying harassment evaluated prevention methods applied practice developed questionnaire helped identify following topics bullying harassment prevalence characteristics sports teams formation negative opinion nature sport tasks physical well team members consequences paper provides empirical conclusions bullying harassment affects youth basketball teams argued existing conflict management systems effectively exploited prevention bullying harassment article expands literature bullying harassment school age grade provides novel opportunities problem solving assessing school activities research limitations investigation conclusions may lack depth address issue proposed conduct depth qualitative studies evaluation similar efforts samples different ethnic cultural background originality study produce novel results bullying harassment junior relations situation extra curricular activities basketball teams future potential professional players developed revealing dynamics relationship team members role coaches represents lack utilisation proven methods prevention bullying harassment teams well others investigation address lack scientific research create meaningful connection teen sports bullying harassment issues
using image processing extract nodular linear shadows key technique computer aided diagnosis schemes study proposes new method extracting nodular linear patterns various sizes medical images developed morphology filter bank creates multiresolution representations image analysis bank filter bank produces nodular linear patterns resolution level synthesis bank used perfectly reconstruct original image decomposed patterns proposed method shows better performance based quantitative evaluation using synthesized image compared conventional method based hessian matrix often used enhance nodular linear patterns addition experiments show method applied followings microcalcifications various sizes mammograms extracted blood vessels various sizes retinal fundus images extracted thoracic images reconstructed removing normal vessels proposed method useful extracting nodular linear shadows removing normal structures medical images
present preliminary results discussion ongoing effort develop prototype volumetric atmospheric optical refraction simulator uses three dimensional nonlinear ray tracing state art physics based rendering techniques tool allow simulation optical curved ray propagation nonlinear refractivity gradient profiles volumetric atmospheric participating media generation radiometrically accurate images resulting atmospheric refraction phenomena including inferior superior mirages horizon viewing conditions looming sinking towering stooping distant objects ability accurately model predict atmospheric optical refraction conditions phenomena important defense commercial applications nonlinear refractive ray trace method currently cpu parallelized well suited gpu compute implementation
aim investigate relationship inflammatory markers platelet size generalized aggressive periodontitis gagp material methods periodontal inflammatory platelet indices compared gagp patients healthy subjects gingival biopsies five patients five healthy subjects examined immunohistochemistry electron microscopy changes patient periodontal platelet indices evaluated months periodontal therapy results platelet size decreased significantly gagp patients compared healthy subjects weak negative correlations platelet size periodontal parameters found gagp patients platelet aggregates adhesion endothelium leucocytes found venules connective tissues gingival biopsies gagp patients mean platelet volume mpv platelet large cell ratio increased periodontal therapy gagp patients increase mpv related decrease bleeding index gagp patients periodontal therapy conclusion platelet size reduced gagp patients compared healthy controls possibly due consumption large platelets sites periodontal inflammation platelets may involved host responses periodontal infection gagp
materials engineering plays key role field energy storage particular engineering materials nanoscale offers unique properties resulting high performance electrodes electrolytes various energy storage devices consequently considerable efforts made recent years fulfill future requirements electrochemical energy storage using advanced materials various multi functional hybrid nanostructured materials currently studied improve energy power densities next generation storage devices review describes recent progress synthesis different types hybrid nanostructures using template assisted non template based methods potential applications recent research efforts utilize hybrid nanostructures enhance electrochemical energy storage properties ion battery supercapacitor discussed review also briefly outlines recent progress new approaches explored techniques fabrication battery structures using hybrid nanoarchitectures
industry corner introduction recent trend toward extreme periods drought shock residents pacific northwest many relied upon heavy water use summer months order make living producers grass seed sod berries nursery crops maintain landscapes high levels certain homeowners recreational facilities commercial properties furthermore population growth reached point even average year precipitation proven insufficient urbanities previously experienced issues water scarcity mcdonald modern climate scenario forced people pacific northwest people around world rethink water use strategies global trend shifted toward greater sustainability tilman mcdonald one potential mitigation strategy cool humid regions oregon willamette valley utilize rainwater harvesting systems alleviate freshwater demand kinkade levario rainwater harvesting logical choice climate zone average annual precipitation corvallis sufficient majority crop production however precipitation occurs almost exclusively nine month period spanning fall spring climate data although annual precipitation adequate irrigation still required least three months every year study considered rainwater harvesting ideally suited cool humid willamette valley excess rainfall wet season could stored use summer months thus decreasing demand municipal water equivalent amount stated rainwater harvesting novel idea studies dating back earlier shown significant watersavings retrofitting homes new features like rainwater harvesting systems boers karpisack even golf courses sporting complexes industrial sites alike making use strategy however methods typically consisted catching rainwater via surface runoff storing retention ponds ferguson strategy less applicable small acreage homeowner wants irrigate property without turn half backyard pond fortunately alternative methods rainwater harvesting make lot sense residential setting irrigated land small relation roof area rain easily harvested study documents construction two distinct rainwater harvesting systems ground cistern ground aquablox matrix storage system gives insight advantages disadvantages
prenatal viral infection identified potential risk factor development neurodevelopmental disorders schizophrenia autism additionally dysfunction gamma aminobutyric acid reelin fragile mental retardation protein fmrp metabotropic glutamate receptor signaling systems also demonstrated two disorders current report characterized developmental profiles selected markers systems cerebella mice born pregnant mice infected human influenza virus embryonic day sham infected controls using sds page western blotting techniques evaluated presence abnormalities mentioned markers brain development cerebellum selected light emerging evidence plays roles learning memory emotional processingall disrupted autism schizophrenia identified unique patterns gene protein expression birth postnatal day childhood adolescence young adulthood exposed control mouse progeny also identified significant differences protein expression fmrp low density lipoprotein receptor glutamic acid decarboxylase kda proteins specific postnatal time points cerebella offspring exposed mice results provide evidence disrupted fmrp glutamatergic reelin signaling exposed mouse offspring explains multiple brain abnormalities observed animal model wiley periodicals inc
microwave millimeter wave analog signal processing asp novel paradigm great promise highspeed microwave millimeter wave systems authors group done intensive research area past years presents overview results cover phaser technologies phaser synthesis techniques various applications
innate lymphoid cells ilc members heterogeneous family lymphoid origin mimics helper cytokine profile ilc involved early effector cytokine mediated responses infections peripheral tissues ilc also play important role chronic skin inflammatory diseases including psoriasis although classical ilc express recently reported presence non classical ilc populations early ilc precursor eilp low ilc development predominately investigated mouse models however humans different transcription factors described ilc identification nfil nuclear factor regulated crucial ilc development response alpha usually used exclude basophils ilc identification however unknown response nfil could relevant induce ilc features lin populations addition also unknown whether peripheral blood population ilc features may skin homing potential participate skin inflammatory chronic diseases report lin low cla population share phenotypic properties basophils expresses several transcription factors ilc commitment inhibitor dna binding nfil promyelocytic leukemia zinc finger plzf thymocyte selection associated high mobility group box protein tox cell factor tcf addition population expresses different ilc markers alpha integrin kit crth ahr prevents apoptosis increases nfil tox plzf expression cdlow population predominantly conspicuous population expresses bet ror gamma lin low population limited type cytokine expression highly expresses lin low population expresses skin homing receptors cutaneous lymphocyte antigen cxcr transmigrates endothelial cells response sdf equivalent lin low population identified control skin shows broader phenotypic diversity cytokine production including remarkably low population lesion non lesion skin psoriasis patients expresses findings suggest identification alternative lin low population ilc features endowed migratory capabilities might contribute immunopathological hallmarks psoriasis
effective transconductance bulk driven operational amplifier opamp significantly vary input common mode voltage variation complicates frequency compensation creates harmonic distortion thus brief presents stabilizing technique reduce variation across input common mode range icmr idea use variable positive feedback structure adaptively control input common mode voltage low voltage bulk driven opamp proposed stabilizing technique implemented well cmos process opamp consumes supply voltage variation reduced across rail rail icmr measured gain unity gain bandwidth mhz opamp loaded parallel omega
aiming problem diagnose soft faults nonlinear analog circuits novel approach extract fault features proposed approach based wigner ville distribution wvd subband volterra model first subband volterra kernels circuit test cleared subband volterra kernels used obtain wvd functions fault features extracted wvd functions taken input data hidden markov model hmm finally classification features using hmms soft fault diagnosis nonlinear analog circuit achieved simulations experiments show method proposed paper extract fault features effectively improve fault diagnosis
nature inspired computing algorithms nics short inherit certain length history tracing back genetic algorithm evolutionary computing since february birth firefly algorithm nics started receive lots attentions researchers around global variants even new species nic algorithms boomed like sprouts rain may disputable question necessity creations new species algorithms observed algorithms fundamentally made several core components exposing components underlying design collection called modern nic optimization algorithms revealed paper core components constructs popular nic algorithms reviewed thereby debunking myths novelty perhaps excitement inventing something really new simply branding nic search method merely name another living creature work also serves general guideline reference algorithm architect wants create new nic algorithm future
novel organomodified nanoclay bentonite reinforced polystyrene polyamide polystyrene polyamide blend matrix develop series nanocomposites using solution processing technique modification bentonite nanoclay performed via ion exchange method serine amino acid properties polystyrene modified bentonite polyamide modified bentonite polystyrene polyamide modified bentonite nanocomposites studied using fourier transform infrared spectroscopy field emission scanning electron microscopy thermogravimetric analysis differential scanning calorimetry ray diffraction cone calorimetry techniques unique honeycomb like pattern observed polystyrene polyamide blend modified bentonite content morphology analysis revealed continuous structure nanoclay particles trapped polystyrene polyamide modified bentonite nanocomposite also showed fine improvement thermal properties system initial decomposition temperature degrees maximum weight loss temperature degrees glass transition temperature degrees series also higher polystyrene modified bentonite polyamide modified bentonite series increasing nanoclay content decreased peak heat release rate polystyrene polyamide modified bentonite nanocomposite indicating improvement nonflammability moreover blend nanoclay series possess better flame retardancy blend nanocomposite series developed
present work aims develop control oriented lumped model investigate fluid dynamic behaviour multi valve spark ignition engines ices specifically attention focused intake phase cylinder air charge estimation purpose spark ignition engine characterised flow rig terms flow coefficients experimental data used define fluid dynamic behaviour different intake system components calibrate validate proposed model developed matlab simulink environment furthermore order evaluate capability zero dimensional code estimate instantaneous cylinder mass flow different operating conditions numerical data compared results one dimensional commercial software comparison numerical experimental data shows good agreement investigation highlights proposed control oriented lumped model represents useful simple tool evaluate engine breathability define proper valve timing authors published elsevier ltd open access article license
background children daily risk exposure organophosphate insecticides common chlorpyrifos cpf exposure pregnant women cpf linked decreased birth weight abnormal reflexes reduction well increased maternal reports signs pervasive developmental disorder aim current study examine long term effects prenatal exposure cpf cbl mice specific focus social repetitive behavior methods female mice treated vehicle cpf cpf gestational days oral gavage postnatal days pnd early development neuromotor ability assessed measuring neonatal reflexes offspring adulthood pnd social behavior investigated using social preference social novelty social conditioned place preference tasks object recognition restricted interest measured repetitive novel object contact task rnoc also assessed order rule possibility cpf administration induced alterations maternal care dams behavior evaluated via maternal retrieval task results cpf treatment resulted delayed development neonatal reflexes pnd pnd mice treated prenatally dose exhibited reduced preference towards unfamiliar conspecific social preference test reduced social conditioned place preference rnoc task mice exposed prenatally dose cpf showed enhanced restricted interest cpf administration impair dams behavior cause memory recognition deficit observed object recognition task conclusions data indicate gestational exposure cpf long term deleterious effects social behavior limits exploration novel objects
objective article illustrates early human development demonstrated magnetic resonance microscopy computer graphics human embryo specimens advanced dimensional sonography clinical obstetrics study design fixed human embryo specimens imaged microscopy coupled computer graphics technology transvaginal sonography used examine embryos ongoing gestations compare embryological findings results advances microscopy allowed detailed visualization embryo specimens computational techniques allowed reconstruction tomographic images render structures high resolution transvaginal sonography produced images demonstrated neural tube week brain anatomy vasculature week craniofacial morphology structures week conclusion microscopy novel technique enables nondestructive high resolution imaging embryo specimens hand sonoembryology allows detailed anatomical visualization vivo basis assessment anomalies well human development
recent literature explored automated pornographic detection bold move replace humans tedious task moderating online content unfortunately scenes high skin exposure people sunbathing wrestling state art many false alarms paper based premise incorporating motion information models alleviate problem mapping skin exposure pornographic content advances bar automated pornography detection use motion information deep learning architectures deep learning especially form convolutional neural networks striking results computer vision potential pornography detection yet fully explored use motion information propose novel ways combining static picture dynamic motion information using optical flow mpeg motion vectors show methods provide equivalent accuracies mpeg motion vectors allow efficient implementation best proposed method yields classification accuracy error reduction compared state art dataset challenging test cases finally present discuss results larger challenging dataset
signaling via met receptor tyrosine kinase met implicated number neurodevelopmental events including cell migration dendritic axonal development synaptogenesis related role development forebrain circuitry recently identified functional promoter variant met gene associated autism spectrum disorder asd association met promoter variant allele significantly enriched families child asd occurring gastrointestinal conditions expression met forebrain mapped detail developing mouse rhesus macaque however mammals expression developing brainstem studied extensively throughout developmental stages brainstem autonomic circuitry implicated asd pathophysiology gastrointestinal dysfunction advance understanding neurodevelopmental influences met signaling brainstem circuitry development employed situ hybridization immunohistochemistry map expression met ligand hgf prenatal development mouse midbrain hindbrain results reveal highly selective expression pattern met brainstem including subpopulation neurons cranial motor nuclei nvii nxii subgroup dorsal raphe barrington nucleus small subset neurons nucleus solitary tract contrast met neither full length known splice variants hgf localized prenatal brainstem pcr revealed hgf expression target tissues met expressing brainstem neurons suggesting met neurons may activated hgf peripheral sources together data suggest met signaling may influence development neurons involved central regulation gastrointestinal function tongue movement swallowing speech stress mood copyright karger basel
way individuals appraise positive emotions may modulate affective experience positive activity scheduling individuals may either engage dampening appraisals think good last amplifying appraisals think deserve cross randomized design used examine consequences appraisal styles participants rated positive affect negative affect four daily walks pleasant locations whilst following dampening emotion focus amplifying focusing good one feels self focus amplifying focusing positive self qualities control instructions difference two amplifying control conditions increased reduced walks however dampening condition significantly differed conditions reducing increasing walk individual differences anhedonia symptoms significantly moderate pattern findings evidence supports view dampening appraisals may one mechanism driving anhedonia may account positive activity scheduling sometimes backfire utilized clinic elsevier ltd rights reserved
current study tested hypothesis mothers experienced child maltreatment aggression within adult relationships may particular risk misinterpreting infant emotions leading less sensitive parenting behaviors participants pregnant women recruited larger longitudinal study investigating role psychosocial environmental risk women young children data collected third trimester pregnancy children years age participants completed projective test designed elicit individual differences perceptions infant emotions observer rated assessment parenting behaviors conducted family home using structural equation modeling tested associations maternal interpersonal aggression exposure perceptions infant emotion parenting behaviors results demonstrated history child abuse intimate partner conflict associated maternal tendency view ambiguous infant facial expressions negative negative attribution bias turn less parenting sensitivity time findings suggest negative attributions infant emotion may mechanism history trauma violence exposure contributes less sensitive parenting mothers implications intervention include need trauma informed clinical services psychoeducational methods help mothers accurately read respond infant emotional expression bids connection
ieee wireless standard specifies physical layer media access control focusing low cost low power transmissions devices making framework choice upper layers developed address internet things iot however standard offers numerous possibilities regarding network topology data transfer model security suite also rapidly evolved since initial release combination factors creating room security issues left hands iot architects like unknown deviations standard highlight paper ensuring aspect security essential broad public industrial acceptance thus growth iot technologies paper provide necessary inputs fully grasp security issues behind standard examining elements need investigated auditors assessing level security specific ieee infrastructure
biotechnological production fatty alcohols important raw materials chemical industry receiving considerable attention recent years fatty alcohols formed reduction fatty acyl coas fatty acyl acps catalyzed fatty acyl reductase far study introduced genes encoding fars arabidopsis thaliana atfar simmondsia chinensis scfar crambe abyssinica hairy roots via agrobacterium rhizogenes mediated transformation efficiency transformation ranged fatty alcohols detected transgenic hairy root lines expressing scfar gene tested lines stearyl alcohol arachidyl alcohol behenyl alcohol produced content varied total fatty acids fatty alcohols amount either exceed transgenic hairy root lines produced nmol fatty alcohols per dry weight low activity scfar detected microsomal fractions isolated selected hairy root lines knowledge first report fatty alcohol production hairy root cultures biotechnol bioeng wiley periodicals inc
backgroundthere limited evidence nationally representative samples changes prescription drug use financial reasons among cancer survivors united states methodsthe national health interview survey used identify adults reported ever told cancer cancer survivors individuals without cancer history measures changes prescription drug use financial reasons included skipping medication doses taking less medicine delaying filling prescription asking doctor lower cost medication buying prescription drugs another country using alternative therapies multivariable logistic regression analyses controlled demographic characteristics number comorbid conditions interactions cancer history number comorbid conditions health insurance coverage main analyses stratified age nonelderly ages years elderly ages years time since diagnosis recently diagnosed years previously diagnosed years resultsamong nonelderly individuals recently diagnosed previously diagnosed cancer survivors likely report change prescription drug use financial reasons without cancer history excess percentage changes individual measures ranging among previously diagnosed survivors among recently diagnosed survivors elderly cancer survivors without cancer history comparable rates changes prescription drug use financial reasons conclusionsnonelderly cancer survivors particularly vulnerable changes prescription drug use financial reasons suggesting targeted efforts needed cancer american cancer society cancer survivors united states likely change prescription drug use financial reasons individuals without cancer history survivors younger years multiple comorbid conditions especially vulnerable financial burden associated prescription drugs see also pages
cystic fibrosis patients suffer chronic lung inflammation inflammation may activate platelets limited data role platelet secreted cytokines platelet cytokines inflammatory effects include vascular endothelial growth factor vegf transforming growth factor beta tgf beta levels cytokines tenfold greater serum plasma due platelet release serum levels may one index platelet content specific index release aggregation isolated platelets postulated altered release platelet cytokines occurs obtained sera plasma outpatients healthy controls measured vegf tgf beta assessed correlations platelet number analyzed cytokine release platelet aggregation collagen analyzed differences maximal platelet aggregation platelet number maximal aggregation levels higher plasma serum levels tgf beta vegf higher levels similar adjusting platelet number serum cytokines correlated platelet count release vegf tgf beta aggregation decreased platelets respectively platelet release source elevated blood proinflammatory cytokines tgf beta vegf platelets patients actually release less cytokines data provide evidence platelet defects
executive functioning associated various aspects school achievement cognitive development children adolescents substantial research investigating associations factors young children support processes parenting less research conducted external factors relating order children adolescents therefore present study investigates one possible factor could correlate school age children adolescents parenting behavior cross sectional study design gathered data children primary schools middle schools gymnasien corresponding parents children underwent standardized task measure computer based erikson flanker task evaluates function error rates response time self report questionnaire used assess parenting behavior multilevel analysis implemented test effects parenting behavior school age children results show significant associations various parenting behaviors children high scores parental involvement parental responsibility associated low error rates erikson flanker task whereas high parental scores inconsistent discipline associated high error rates correlations parenting behavior remained significant despite controlling child age maternal education family income baseline performance congruent trails erikson flanker task associations found parental behavior reaction time erikson flanker task results indicate important association parenting behaviors skills school age children foster necessity inform parents ways optimally support children cognitive development
autophagy essential degradation pathway clearing abnormal protein aggregates mammalian cells responsible protein homeostasis neuronal health several studies shown autophagy deficits occurred early stage alzheimer disease autophagy plays important role generation metabolism beta amyloid beta assembling tau thus malfunction may lead progress considering evidences autophagy may new target developing drugs far number mammalian target rapamycin mtor dependent independent autophagy modulators identified positive effects treatment review summarized latest progress supporting role autophagy deficits potential therapeutic effects autophagy modulators
aim provide systematic overview longitudinal studies different smoking specific parenting practices perceived parental norms influences smoking specific monitoring availability cigarettes home household smoking rules non smoking agreements smoking specific communication parental reactions useful tools prevention youth smoking method medline psychinfo search identified studies published december two independent researchers identified eligible studies study quality assessed using newcastle ottawa scale nos results systematic search resulted longitudinal studies per parenting practice studies scored nos indicating overall moderate quality results complete smoking house rules showed preventive effect smoking onset furthermore availability cigarettes frequency quality communication parental reaction conflict engagement norms showed significant non significant effects significant results line expectations availability cigarettes frequent communication smoking predicted smoking whereas high quality communication negative reactions punishments setting norms parents showed preventive effect effects found non smoking agreements number studies limited draw conclusions parenting strategies research reliable valid instruments stages smoking addition onset potential moderators mediators warranted conclusion evidence supports effectiveness smoking specific parenting research required elsevier ltd rights reserved
channel morphology step pool represents morphodynamic complex influenced large woody debris litter fall aim paper determine impact litter fall channel morphology step pool general conclusions regarding influence litter fall channel morphology step pool based results geomorphological analyses study showed differences river segments without foliaged steps pools following foliaged steps finer grain size composition sediment also larger shallower higher retention capacity foliaged steps help decrease potential energy water effectively litter fall permanently preserved step makes resistant extreme water flows result enables development fully functional channel morphology step pool
approximately patients receiving pertuzumab directed therapy human epidermal growth factor receptor positive breast cancer develop chemotherapy induced diarrhea cid loperamide octreotide frequently used treat cid diarrhea occurs neither used prophylactically targets underlying mechanism previous studies suggest blocking epidermal growth factor receptor may cause excess chloride secretion resulting diarrhea crofelemer derived red latex croton lechleri tree blocks gastrointestinal cystic fibrosis transmembrane regulator calcium activated chloride channels food drug administration approved relief diarrhea hiv aids patients anti retroviral therapy crofelemer systemically absorbed relatively side effects presents targeted approach preventing cid patients receiving pertuzumab based therapy halt diarrhea prevention prophylaxis crofelemer positive breast cancer patients receiving trastuzumab pertuzumab docetaxel paclitaxel without carboplatin nct phase randomized open label trial aims recruit patients medstar sites adults positive breast cancer treated trastuzumab pertuzumab docetaxel paclitaxel thp trastuzumab pertuzumab docetaxel carboplatin tchp randomized receive crofelemer medication diarrhea prophylaxis primary endpoint incidence grade diarrhea consecutive days cycles thp tchp secondary endpoints include overall incidence duration severity diarrhea time onset diarrhea use anti diarrheal medications stool frequency consistency quality life halt provide important information feasibility tolerability crofelemer preventing diarrhea patients receiving thp tchp
paper utilizes jumarie modified riemann liouville derivative extended expansion method discuss soliton solutions nonlinear time fractional parabolic equations exact solutions expressed terms hyperbolic trigonometric functions solutions may useful desirable explain nonlinear physical phenomena genuinely nonlinear fractional calculus several constraint conditions naturally emerge results obtained conditions also listed elsevier gmbh rights reserved
pupose although reports vitamin vitd insufficiency immune mediated hypothyroidism association vitd thyroid stimulating hormone tsh levels yet shown aim examine vitd tsh levels among postmenopausal women conditions prevalent elderly women methods clinic records postmenopausal women routine maintenance visits reviewed patients examined symptoms related thyroid function osteoporosis participants divided three subgroups according tsh levels miu patient characteristics vitd levels compared subgroups multivariate linear regression model constructed using serum vitd serum tsh dependent variables identify factors independently associated laboratory values results two hundred nighty nine postmenopausal women included average age years old vitd insufficient deficient participants tsh low women tsh high remaining normal tsh levels subjects low tsh significantly higher vitd concentrations compared two groups value multivariate regression analysis tsh contributing factor age significant predictor vitd levels meanwhile predictor including age vitd identified tsh levels linear regression analysis conclusion age independent predictor serum vitd study population though suppressed tsh associated higher vitd levels association linear tsh vitd postmenopausal women
background survivors myocardial infarction considerable risk developing cardiovascular events including recurrent heart failure stroke death patients type diabetes mellitus stable ischemic heart disease sihd worse outcomes nondiabetic counterparts previous may particularly high risk yet little known effect adding prompt revascularization intensive medical therapy high risk group patients methods carried post hoc analysis bypass angioplasty revascularization investigation diabetes trial randomized patients type diabetes mellitus sihd prompt revascularization percutaneous coronary intervention coronary artery bypass grafting addition intensive medical therapy intensive medical therapy alone previous status defined history pathologic waves primary endpoints death nonfatal fatal nonfatal fatal stroke congestive heart failure composite death stroke results patients evaluable data previous patients differences year event free rates cause death stroke congestive heart failure death stroke randomized prompt revascularization addition intensive medical therapy randomized intensive medical therapy alone conclusion diabetic patients sihd previous adding prompt revascularization intensive medical therapy yielded benefit compared intensive medical therapy alone findings underscore importance intensive medical therapy mitigating ischemic events copyright wolters kluwer health inc rights reserved
purpose examine attitudes toward smoke free policies perceptions cigarette use among homeless adults approach cross sectional qualitative study conducted setting study setting comprised seven transitional homeless shelters indoor smoke free policies san diego county facilities differed outdoor restrictions smoking participants sixty six current former smokers study participants method participants completed questionnaire smoking behaviors perceived antitobacco norms attitudes toward smoke free policies attended focus group interview explored topics used directed content analysis approach analyze focus group transcripts results clients facilities outdoor restrictions smoking stronger perceived antitobacco norms facilities without restrictions identified following major themes attitudes toward smoke free policies use cigarettes addictive potential cigarettes vulnerability tobacco industry marketing interest smoking cessation consensus smoke free policies important limited secondhand smoke exposure nonsmokers children curious cigarettes particularly could smoked areas smoking prohibited used cessation aid conclusion study homeless adults strong support indoor outdoor smoke free policies however misperceptions cigarettes could used indoors could threaten antitobacco norms highlighting opportunities educate potential risks cigarette use among homeless individuals
broadband infrared response attracted great attention due potential applications silicon based photodetectors studied broadband infrared response sulfur hyperdoped silicon femtosecond laser irradiation fabricated photodiodes exhibit several photoresponse spectral peaks near mid infrared region electromagnetic spectrum onset energies corresponding distinct sub band gap photoresponse features consistent active energy levels known sulfur within silicon band gap technique may offer promising approach fabricate low cost broadband silicon based detectors elsevier rights reserved
background pathophysiology infantile colic poorly understood though various studies report gut microbiota dysbiosis colicky infants aimed test hypothesis colic related dysbiosis associated visceral hypersensitivity triggered altered luminal milieu methods fecal samples seven colicky seven non colicky infants studied fecal supernatants infused colons mice specimen visceral sensitivity subsequently assessed animals recording abdominal muscle response colorectal distension crd electromyography emg serine cysteine protease activities assessed specific substrates infant fecal microbiota composition analyzed dna extraction rrna gene pyrosequencing key results colicky infants triggered higher emg activity non colicky infants response largest crd volumes overall assessed area curve emg across crd volumes infant crying time strongly correlated mouse emg activity microbiota richness phylogenetic diversity increased colicky group without showing prominent microbial composition alterations bacteroides vulgatus bilophila wadsworthia increased colicky group bacteroides vulgatus abundance positively correlated visceral sensitivity differences found protease activities conclusions inferences luminal contents colicky infants trigger visceral hypersensitivity may explain excessive crying behavior infants additional studies required determine nature compounds involved mechanism action potential implications intestinal microbiota generation
background karnataka state continues highest rates maternal mortality south india live births lower national estimates live births various barriers exist timely appropriate utilization services pregnancy childbirth postpartum study aimed describe patterns determinants routine emergency maternal health care utilization rural karnataka state india methods study conducted karnataka purposive sampling used convene twenty three focus groups twelve individual interviews community health system representatives auxiliary nurse midwives staff nurses accredited social health activists community leaders male decision makers female decision makers women reproductive age medical officers private health care providers senior health administrators district health officers obstetricians local researchers familiar setting language conducted focus groups interviews researchers known community participants discussions audio recorded transcribed translated english analysis thematic analysis approach taken utilizing priori thematic framework well inductive identification themes results women focus groups reported regular antenatal care attendance average four visits often high risk pregnancies antenatal care typically delivered periphery non specialised providers participants reported sought care women experienced danger signs complications postpartum care reportedly rare mainly sought purpose neonatal care factors influenced women care seeking included limited autonomy poor access funding transport non emergent conditions perceived poor quality health care facilities costs care conclusions rural south indian communities reported regular use health care services pregnancy delivery uptake maternity care services attributed new government programmes increased availability maternity services nevertheless women delayed disclosure pregnancy first antenatal visit community based initiatives enhanced encourage early disclosure pregnancies provide community information regarding importance facility based care health facility infrastructure rural karnataka also enhanced ensure consistent power supply improved cleanliness wards
paper proposes novel approach building natural language interface relational database nli rdb using conversational agent information extraction object relational mapping orm framework help disambiguating user queries guiding user interaction play important role named entities extraction order map natural language queries database queries orm framework hibernate framework resolves impedance mismatch object oriented paradigms oop relational databases rdbs oop concepts differ rdb concepts thus reduces complexity generating sql statements also utilizing orm framework rdbs entities mapped real world objects bring rdbs step closer user addition orm framework simplify interaction oop rdbs developed nli rdb system allows user interact objects directly natural language navigation rather using sql statements direct interaction tends easier acceptable humans technically orientated sql knowledge nli rdb system also offers friendly interactive user interface order refine query generated automatically nli rdb system evaluated group participants combination qualitative quantitative measures experimental results show good performance prototype excellent user satisfaction
background foot ankle injuries common football prevention strategies exist order decrease incidence injuries minimize number days player unavailable selection methods injuries recorded season period team playing english premier league epl present epidemiology foot ankle injuries within professional football club offer calculation may use future identify areas injury prevention results anterior talo fibular ligament atfl injuries fifth metatarsal fractures high impact common resulted significant time periods player unavailable conclusions first time epl club prepared publish data regarding injury findings may used others focus prevention strategies injuries highest impact european foot ankle society published elsevier ltd rights reserved
fxf third generation antihistamine drug osthole assumed natural antihistamine alternative paper compares peripheral blood mononuclear cell pbmc incubation fxf osthole studying fxf osthole histamine cytokine secretion pbmc vitro cultures mabtech kits determined interleukins beta tnf alpha influence active substances cytokine secretion pbmc serum assessed cytokines beta tnf alpha cytokine levels secreted untreated pbmcs pure culture medium formed absolute control ctrl determined osthole affects pbmc cytokine secretion almost precisely extent fxf beta tnf addition osthole greater blocking ability fxf moreover observed significantly decreased level histamine osthole theatment compared histamine alone meanwhile fxf significantly decrease level increased histamine data indicates osthole strong role allergic inflamation results confirm hypothesis osthole natural histamine antagonist therefore beneficially used antihistamine treatment conditions allergies
inflammatory bowel disease periodontitis described disproportionate mucosal inflammatory response microbial environment susceptible patients moreover two conditions share major environmental lifestyle related risk factors despite intriguing pathogenic parallel large scale studies basic research recently considered periodontal outcomes relevant data mounting consistent arguments recent epidemiologic studies animal models two conditions might related article comprehensive critical date review current evidence future prospects understanding biologic epidemiologic relationships periodontal status inflammatory bowel disease
article examines integrated watershed management annapolis river basin nova scotia perspective community based watershed organization draws experiences clean annapolis river project carp provide case study financial institutional human political social capacity small non governmental organization implementing integrated watershed management carp guiding principles utilizing science leadership community engagement achieve ecologically healthy watersheds align integrated watershed management approach using examples carp programming projects article describes successes challenges encountered implementation community based integrated watershed management
background immune therapy using monoclonal antibodies cytotoxic lymphocyte associated antigen ctla programmed cell death receptor various cancers reported cause thyroid dysfunction little known however underlying pathogenic mechanisms course hypothyroidism subsequently develops report use change thyroglobulin thyroid antibody levels patients immune therapy develop hypothyroidism better understand pathogenesis well examine status hypothyroidism long term methods report case series patients developed hypothyroidism initiation immune therapy either anti alone combination anti ctla available thyroid antibodies including anti thyroglobulin anti anti thyroid peroxidase anti tpo thyroid stimulating immunoglobulin tsi noted initial thyroiditis phase well hypothyroid phase persistence remission hypothyroidism noted months summary thyroiditis phase patients elevated titers elevated anti elevated tsi titers decreased hypothyroid phase permanent hypothyroidism noted cases conclusion hypothyroidism following initiation immune therapy immunologic non immunologic mediated mechanisms likely persistent
objectives compare cumulative ionizing radiation patients inflammatory bowel disease ibd irritable bowel syndrome ibs years study radiation exposure change time patients newly diagnosed ibd factors associated radiation exposure material methods radiological investigations performed january december retrospectively recorded patients crohn disease ulcerative colitis ibs analyses done mann whitney chi square test results median total cumulative radiation exposure msv inter quartile range iqr iqr ibs iqr proportion patients exposed msv study period ibs significantly higher patients compared patients ibs respectively turn patients significantly higher doses patients ibs risk factors radiation exposure female gender early onset ileocolonic location previous surgery depression ibs widespread pain ibs newly diagnosed significant decline median cumulative radiation dose msv study period conclusions patients greatest risk high cumulative radiation exposure decline exposure late non colectomized patients patients ibs relatively low risk cumulative radiation exposure
polluted insulators frequently face flashover accident threatens safety stability power system order help reduce occurrence flashover necessary study contamination characteristics insulators influence factors study contamination insulator simulated eulerian multiphase model computational fluid dynamics flow field around insulators calculated volume fraction particle phase used characterise pollution degree insulator surface results show pollution mainly distributed windward side leeward side insulator crosswind side insulator slightly contaminated four influence factors wind velocity particle concentration particle diameter flow angle different effects insulator contamination among factors particle concentration contributes whole contamination degree insulators wind tunnel contamination test insulator carried verify feasibility numerical simulation found simulated contamination distribution variation contamination degree wind velocity well coincide results wind tunnel test numerical simulation study practical studying insulator contamination
clifford algebra geometric algebra simple intuitive way model geometric objects transformations operating high dimensional vector spaces significant computational costs practical use requires dedicated software hardware architectures directly support clifford data types operators paper family embedded coprocessors native execution operations presented paper shows evolution coprocessor family focusing latest two architectures offer direct hardware support five dimensional clifford operations proposed coprocessors exploit hardware oriented representations elements operators properly conceived obtain fast performing implementations coprocessor prototypes implemented field programmable gate arrays development boards show significant speedups one order magnitude respect baseline software library gaigen running general purpose processor paper also presents execution analysis different based applications namely inverse kinematics robot optical motion capture raytracing medical image processing showing good speedups respect baseline general purpose implementation
extranodal natural killer cell lymphoma aggressive malignancy putative cell origin minority deriving cell lineage pathologically malignancy occurs two forms extranodal cell lymphoma nasal type aggressive cell leukaemia lymphoma occur commonly nose upper aerodigestive tract less commonly non nasal areas skin gastrointestinal tract testis salivary gland rarely disseminated disease leukemic phase genetic analysis showed mutations genes involved jak stat pathway rna assembly epigenetic regulation tumor suppression initial clinical evaluation positron emission tomography computed tomography quantification plasma ebv dna mandatory useful response monitoring prognostication stage diseases combined chemotherapy radiotherapy sequentially concurrently best approach conventional anthracycline containing regimens ineffective replaced non anthracycline containing regimens preferably including asparaginase radiotherapy alone associated high systemic relapse rates avoided stage iii diseases non anthracycline regimens containing asparaginase standard relapsed refractory cases blockade programmed death protein recently shown promising results high response rates era effective non anthracycline containing regimens autologous haematopoietic stem cell transplantation hsct shown beneficial however allogeneic hsct may considered high risk advanced stage patients remission relapsed refractory patients responding salvage therapy prognostic models taking account presentation interim end treatment parameters useful triaging patients different treatment strategies
motion estimation key building block image processing pipelines many different contexts ranging efficient coding video sequences consumer electronics domain dvd professional medical applications many block matching approaches proposed literature motion detection compensation general including lossless lossy algorithms however real time medical imaging applications characterized high frame rates needs low latency jitter accuracy robustness noise quite difficult achieve standard block matching methods introduce new hybrid image processing approach block matching takes advantage types algorithms lossless lossy adapts image content noise provides high flexibility speed accuracy tradeoff presented approach successfully tested interventional ray fluoroscopy cardiac ultrasound images sequences
study aimed investigate effectiveness game based learning supporting education particularly network security topics attain objective post test administered participant study adopted quasi experimental research design involving participants finding study suggested participants participated game based learning outperformed participants control group
work introduce approach nonlinear model predictive based called state dependent riccati equation sdre approach model first cast form similar linear state space representation algebraic riccati equation constructed based similarity linear quadratic regulator obtain stable nmpc method requires solution riccati equation sampling period simulation results quite encourageing
backgroundthe liver major site alcohol metabolism body therefore primary target organ ethanol etoh induced toxicity study investigated invitro response human liver cells different etoh concentrations perfused bioartificial liver device mimics complex architecture natural organ methodsprimary human liver cells cultured bioartificial liver device treated hours medium containing low medium high etoh control culture kept untreated gene expression patterns etoh concentration monitored using affymetrix human gene gene chips scaled expression profiles differentially expressed genes degs clustered using fuzzy means algorithm addition functional classification methods kegg pathway mapping also machine learning approach random forest utilized resultsa number etoh etoh etoh genes found differentially expressed dose response relationships identified clusters expressed genes showed monotonic threshold nonmonotonic hormetic behavior functional classification degs revealed low medium etoh concentrations operate adaptation processes alterations observed high etoh concentration reflect response cellular damage genes displaying hormetic response functionally characterized overrepresented cellular ketone metabolism carboxylic acid metabolism altered expression genes bahd hfb identified sufficient classify samples according applied etoh doses conclusionsdifferent pathways metabolic epigenetic regulation affected etoh exposition partly undergo hormetic regulation bioartificial liver device gene expression changes observed high etoh concentrations reflect aspects situation alcoholic hepatitis humans
purpose resistance capacitance inductance anisotropic conductive film acf connections determine high frequency electrical characteristics presence capacitance inductance acf joint contributes time delays cross talk noise well simultaneous switching noise within circuit purpose paper establish experimental method estimating capacitance inductance typical acf connection help provide detailed understanding high frequency performance acf assemblies design methodology approach experiments transient response acf joint performed using digital oscilloscope capable achieving required resolution equivalent circuit model proposed order quantify capacitance inductance typical acf connection model fitted experimental data full model consisted two resistors inductor capacitor findings capacitance inductance typical acf connection estimated measured transient response using kirchhoff voltage law method estimation transient response discussed rlc effects high frequency electrical characteristics acf connection research limitations implications decay time deviation calculation experiment may resulted skin effect high frequency response adhesive surrounding joint well main reason may capacitance zctric lost research work done determine accurately dielectric losses anisotropic conductive adhesive aca joint originality value paper presents new method characterise high frequency properties aca interconnections use engineers evaluating performance acf materials high frequency applications
several manualized psychotherapies treating borderline personality disorder bpd validated randomized controlled trials approaches highly specialized offering different formulation bpd different mechanisms recovery made possible mental health clinicians challenged degree specialization clinical resources approaches require empirically validated adherent forms effective treatments renewed optimism treatment bpd clinicians may feel limited ability offer may integrate eclectic assortment features different treatments article evaluate four major evidence based treatments bpddialectical behavioral therapy mentalization based treatment transference focused psychotherapy general psychiatric managementand possible modes implementation adherent integrative forms models implementing diverse treatment approaches evaluated potential advantages combining evidence based treatments discussed along cautionary notes proposal providing stepwise care assessment clinical severity presented means achieving system wide changes greater access care
preparing effective workforce high technology goal academic industry training engine drives innovation product development united states century last years technician training comprised combination two year academic programs internships apprentice training extensive job training ojt recently especially silicon valley technicians four year college degrees well relevant hands training characterization general microscopy particular essential tool process development manufacturing failure analysis training broad range skills practice challenging especially community colleges workforce studies sri boeing suggest even four year colleges often provide relevant training experience laboratory skills especially design experiments analysis data companies high tech report difficulty finding skilled labor especially industry specific experience foothill college partnership ucsc sjsu nasa ames developed microscopy training program embedded research laboratory partnership university government providing hands experience advanced instrumentation experimental design problem solving real world context small business innovators environment called collaboratory program builds afm sem training foothill provides affordable training sem tem cost recovery model addition instrument engineering training collaboratory also supports academic personal growth multiplayer social network students faculty researchers innovators
postpartum depression affects approximately mothers however pathological mechanisms still remain unclear ovariectomized adult mice received administration estrogen progesterone subsequent alone termed hormone simulated pregnancy hsp affective behaviors assessed forced swim tail suspension tests hippocampal neuronal nitric oxide synthase nnos nitric oxide cyclic amp camp response element binding protein creb phosphorylation phosphor creb neurosteroidogenesis examined withdrawal hsp mice days early mice days late mice depressive like behaviors observed early mice late mice levels nnos phosphor creb increased hsp mice followed significant decline early mice subsequent restoration late mice treatment early mice donor alleviated depressive like behaviors decline phosphor creb nnos inhibitor scavenger caused depressive like behaviors reduced phosphor creb hsp mice late mice notably levels steroidogenic enzymes star pscc elevated late mice sigma receptor sigma agonist could alleviate depressive like behaviors decline nnos creb early mice pharmacological blockade deficiency sigma late mice caused depressive like behaviors decline nnos creb reduction hippocampal brain derived neurotrophic factor bdnf methyl aspartic acid nmda receptor nrb phosphorylation early mice could recover late mice sensitive blockade sigma nmda receptor agonist trkb receptor activator could correct decline nnos creb early mice findings indicate activation sigma alleviate postpartum depression increasing nnos creb activities
interactive evolutionary computation iec solution evaluated human user usually total number examined solutions small applications hearing aid design music composition single solution evaluated time human user moreover accurate precise numerical evaluation difficult based considerations formulated iec model minimum requirement fitness evaluation ability human users following assumptions evaluate single solution time memorize single previous solution evaluated evaluation result current solution whether better previous one best solution among evaluated ones identified pre specified number evaluations paper first explain iec model detail next propose style algorithm iec model propose offline meta level approach automated algorithm design iec model main feature approach use different mechanism mutation crossover random initialization generate solution evaluated computational experiments test problems approach compared style algorithm solution generation mechanism pre specified fixed throughout execution algorithm
primary myelofibrosis one philadelphia negative chronic myeloproliferative neoplasms rare disease featured cytopenias hepatosplenomegaly although etiology disease still unknown knowledge pathology prognosis improving last years furthermore jak inhibitor ruxolitinib become available hungary since beside high efficacy spleen volume reduction myelofibrosis associated symptoms novel therapy also exerts disease modifying effect therefore ruxolitinib may improve life expectancy treatment approach myelofibrosis changed years gives reason summary
study aims introduce novel device mechanical ventilator pulse oximeter work synchronization serial communication technique used enable communication pulse oximeter ventilator spo value pulse rate read pulse oximeter transmitted mechanical ventilator transmitter receiver lines fuzzy logic based software developed mechanical ventilator interprets values calculates percentage oxygen fio positive end expiratory pressure peep delivered patient fuzzy logic based software developed check changing medical states patients produce new results fio peep according new state fio peep values delivered ventilator patient calculated way without requiring arterial blood gas analysis experiments feed backs physicians show device makes possible obtain successful results compared current practices
across kingdoms tree life calcium essential element used cells respond adapt constantly changing environments multicellular organisms plays fundamental roles fertilization development adulthood inability cells regulate lead pathological conditions ultimately culminate cell death one pathological condition manifested parkinson disease second common neurological disorder humans characterized aggregation protein alpha synuclein review discusses current evidence implicates pathogenesis parkinson disease understanding mechanisms signaling contributes progression disease crucial development effective therapies combat devastating neurological condition
complex network abstract topology large number nodes edges reality reveal influences internal network topology network connectivity vulnerability characteristics hotspot current research paper analyze influence assortativity according newman definition assortativity given degree distribution fully understand influence assortativity change assortativity see topology network changes find existing greedy algorithm improve assortativity effectively first put forward deterministic algorithm based degree distribution uncertain algorithm based probability distribution increase assortativity deterministic algorithm create certain network large assortativity without changing node degree uncertain algorithm increase assortativity continuously changing connection edges uncertain algorithm creates different graphs time result algorithm uncertain test algorithms three networks network network email network compare greedy algorithm experimental results show uncertain algorithm performs better greedy algorithm three networks large span assortativity deterministic algorithm performs well real world network find increase assortativity coefficient network nodes network peer peer also show assortativity increase networks nodes networks status obtain large span assortativity fully understand change network topology basis analyze changes clustering coefficient using uncertain algorithm based probability distribution increase assortativity find certain correlation assortativity clustering study micro influence uncertain algorithm network reason change clustering coefficient explained calculate changes giant branches small branches changes number nodes giant branches number small branches show scale giant branches becomes smaller means connection nodes giant branches becomes closer increase number small branches means network whole becomes fragile show uncertain algorithm changes topology network without changing degree nodes network use algorithm change network obtain larger span assortativity study
objectives study examined relation team weigh ins self weighing frequency collegiate male athletes internalization body ideals social pressures weight body body satisfaction dietary intent negative affect drive muscularity bulimic symptomatology design methods used cross sectional survey design collected data electronically male intercollegiate athletes results athletes self weighed times per week reported pressure lose weight lean muscular engaged muscle building behaviors frequently dieted often highest level bulimic symptomatology athletes teams conducted mandatory weigh ins engaged muscularity behaviors dietary restriction conclusion weighing particularly conducted voluntarily may contribute overconcern appearance body size shape weight turn lead variety behaviors related eating body change elsevier ltd rights reserved
advances understanding molecular mechanisms targets immune regulation led widespread use biologic targeted therapies reformed course many disabling diseases however expanded use various side effects including cutaneous emerged many times clear cut relationship exists drug clinical manifestations however biopsy warranted various histopathological patterns may observed may cause confusion dermatopathologist aim review shed light different histopathological patterns observed manifestation secondary biologics
paper proposes torque measurement method two toy motors aim study basic principles electric motors generators lorentz force law laboratory experiment two motors directly coupled used driver generator respectively generator functions electric brake rotational speed sensor since experimental setup need torque tester handling easy confirmed demonstration tests twin characteristics motors motional electromotive force lead reasonable results torque estimation institute electrical engineers japan published john wiley sons inc
background south asians sas well documented risk mortality related coronary artery disease cad however lack evidence guide implementation dissemination primary secondary interventions control deter progression cad sas objective aim study explore describe self regulation behaviors sas cad using leventhal common sense model methods mixed methods study quantitative data collected using survey questionnaires demographics illness perception questionnaireyrevised coping self regulation behaviors completing surveys subset sample participated individual face face telephone interviews results total sas enrolled age years average participants rated high negative perceptions addition discussed desi diet stress lack physical activity ignoring symptoms kismet fate important perceived causes cad participants modified lifestyle cad event participants expressed regret changed lifestyle earlier experiencing early symptoms cad conclusion findings study enhance understanding self regulation behaviors sas cad ultimately findings inform development implementation targeted interventions address culture specific lifestyle modification sas cad
increasing awareness detrimental health impact frailty older adults high prevalence malnutrition segment population experts arenas need cognizant overlap constructs diagnosis treatment frailty malnutrition lack consensus regarding definition malnutrition assessed consensus definition frailty agreement measured separate assessment tools exist malnutrition frailty however intersection concepts measures narrative review highlights intersections within screening assessment tools including weight loss decreased body mass functional capacity weakness handgrip strength potential identification minimal set objective measures identify least consider risk conditions proposed frailty malnutrition also shown result similar negative health outcomes consequently common treatment strategies studied including oral nutritional supplements many outcomes treatment relate concepts frailty malnutrition research questions typically focused frailty concept leading possible gaps missed opportunities understanding effect complementary interventions malnutrition better understanding conditions overlap may improve treatment strategies frail malnourished older adults
matrix blocking common method improving computational efficiency pagerank blocking rules hard determined following calculation complicated tackling problems propose minimum blocking method driven result needs accomplish parallel implementation pagerank algorithm minimum blocking stores element necessary result matrix return following calculation becomes simple consumption transmission cut experiments several matrixes different data size different sparsity degree results show proposed method better computational efficiency traditional blocking methods
converging evidence identified cognitive control deficits internet gaming disorder igd recently mounting evidence revealed resting state functional connectivity rsfc structural connectivity frontostriatal circuits could modulate cognitive control healthy individuals unfortunately relatively little known thoroughly circuit level characterization frontostriatal pathways dorsal ventral striatum resting state association cognitive control igd current study differences striatum volume rsfc networks investigated young igd individuals healthy controls meanwhile cognitive control deficits assessed stroop task performances neuroimaging findings correlated stroop task behaviors igd subjects demonstrated increased volume right caudate nucleus accumbens nac well reduced rsfc strength dorsal prefrontal cortex dlpfc caudate orbitofrontal cortex ofc nac nac volumes positively correlated internet addiction test scores igd caudate volume dlpfc caudate rsfc correlated impaired cognitive control incongruent errors stroop task igd consistent substance use disorder sud findings detected striatum volume frontostriatal circuits rsfc differences igd healthy controls provided evidence degree similarity igd sud importantly cognitive control deficits igd correlated reduced frontostrital rsfc strength hoped results could shed insight neurobiological mechanisms igd suggest potential novel therapeutic targets treatment
butanol advanced biofuel gained great attention due environmental benefits superior properties compared ethanol however cost biobutanol production via conventional acetone butanol ethanol abe fermentation clostridium acetobutylicum economically competitive hampered industrial application strain performance downstream process greatly impact economics biobutanol production although various engineered strains carefully orchestrated metabolic sporulation specific pathways developed none ideal industrial biobutanol production strain improvement necessary develop advanced genome editing tools deep understanding cellular functioning genes metabolic regulatory pathways processes integrated product recovery increase fermentation productivity continuously removing inhibitory products generating butanol abe concentrated solution review provide overview recent advances acetobutylicum strain engineering process development focusing situ product recovery deep understanding systematic cellular bioinformatics exploration state art genome editing tools crispr cas targeted gene knock knock would play vital role clostridium cell engineering biobutanol production developing advanced hybrid separation processes situ butanol recovery discussed detailed comparison advantages disadvantages various recovery techniques also imperative economical development biobutanol elsevier inc rights reserved
surprisingly minimal appearance cues lead perceivers accurately judge others personality status politics investigated people precision judging characteristics unknown person based solely shoes wears often participants provided photographs shoes separate session completed self report measures coders rated shoes various dimensions ratings found correlate owners personal characteristics new group participants accurately judged age gender income attachment anxiety shoe owners based solely pictures shoes indeed used evaluate others least domains elsevier inc rights reserved
safety key concern design operation development light rail systems including trams streetcars impose crash risks road users terms crash frequency severity aim study identify key traffic transit route factors influence tram involved crash frequencies along tram route sections melbourne random effects negative binomial renb regression model developed analyze crash frequency data obtained yarra trams tram operator melbourne renb modelling approach account spatial temporal variations within observation groups panel count data structures assuming group specific effects randomly distributed across locations results identify many significant factors effecting tram involved crash frequency including tram service frequency tram stop spacing tram route section length tram signal priority general traffic volume tram lane priority ratio platform tram stops findings provide useful insights route section level tram involved crashes urban tram streetcar operating environment method described represents useful planning tool transit agencies hoping improve safety performance elsevier ltd rights reserved
objects various types mechanical joints among commonly built joints implement vocabulary simple constrained motions kinematic pairs used build complex behaviors defining physically correct joint geometry crucial realistic appearance models motion typically parts geometry stay contact fabrication direct design joint geometry often requires effort design rest object geometry requires design components stay precise contact aligned parts allow desired range motion present interactive system creating physically realizable joints user controlled appearance system minimizes cases completely eliminates need user manipulate low level geometry joints achieved automatically inferring small number plausible combinations joint dimensions placement orientation part geometry user making final high level selection based object semantic user studies demonstrate functional results satisfying appearance obtained quickly users minimal modeling experience offering significant improvement time required joint construction compared standard modeling approaches
exposure polycyclic aromatic hydrocarbons pahs occurs respiratory digestive dermal absorption biomonitoring takes pathways account sensitive specific biomarkers required different gaseous pahs metabolites used due abundance atmospheric mixtures none selected better biomarker others identify best candidates assessing occupational airborne exposure relation atmospheric levels naphtalene fluorene phenanthrene urinary metabolites concentrations studied carbon electrode workers group linear mixed effects models built select explanatory variables estimate variance component urinary creatinine predictor metabolites levels confirming importance diuresis interpreting results high significance pre shift sampling time combined positive coefficients post shift indicated urine sampled end workday association pre shift urine avoid misinterpretations among metabolites studied urinary hydroxyfluorene hydroxyphenanthrene showed highest increase variance explained models inclusion individual atmospheric levels explanatory variable priority could given hydroxyfluorene due higher excretion levels hydroxyphenanthrene elsevier rights reserved
objective study create computer vision algorithms autonomous multiclass identification amber nuggets colour applying proposed methods automated production sorting system developed system used example combination conveyor systems case requires distinguishing objects many classes high rate flow objects order achieve proposed system operates colour features selection algorithm classifier training grouping voting reject option developed developed system used automated amber sorting line increase quantities sorted amber nuggets applied algorithms gave highest accuracy amber nugget expert database consisting classes
transmembrane signal transduction process whereby ligand binds external surface cell membrane elicits physiological response specific ligand cell type appreciated numerous disease states represent disturbances normal transmembrane signaling mechanisms current paper focus attention mesangial cell glomerular microcirculation prototypical model system understanding normal abnormal transmembrane signaling processes among major receptor effector mechanisms transmembrane signal transduction mesangial cell paper emphasizes phospholipase effector response growth factors vasoactive hormones post translational transcriptional pathways regulation phospholipase phospholipase described including consideration perturbations systems characterize two disease models namely acute cyclosporine nephrotoxicity early diabetic glomerulopathy
backgroundcompare glycated hemoglobin hba diagnostic tests prediabetes diabetes plasma glucose criteria compare metabolic profiles people classified hba versus glucose levels methodsparticipants recruited san juan overweight adults longitudinal study participants primarily hispanic without previously diagnosed diabetes aged years participants classified normal glycemic prediabetes diabetes basis baseline hba plasma glucose criteria compared respect baseline cardiometabolic factors resultsthe participants mean age years men thirty one percent diagnosed prediabetes plasma glucose criteria hba diagnosed diabetes plasma glucose criteria hba overall concordance rate area receiver operating characteristic curve hba compared plasma glucose criteria impaired glucose diabetes worse cardiometabolic profile seen within subgroups met hba plasma glucose criteria diabetes prediabetes diagnosed prediabetes plasma glucose criteria significantly higher systolic blood pressure higher homeostatic model assessment diagnosed using hba participants diagnosed diabetes plasma glucose criteria lower body mass index smaller waist circumference lower insulinogenic disposition indices higher homeostatic model assessment insulin resistance diagnosed hba conclusionslow concordance seen hba glucose measurements hba good test prediabetes shows reasonable validity diabetes high risk predominantly female hispanic population people classified hba plasma glucose criteria show different metabolic profiles combined test may ideal
kind core cross linked poly ethylene glycol graft dextran nanoparticles cpd nps prepared simple chemical cross linking method reduction dual response drug delivery resultant cpd nps homogeneous spherical structure sizes doxorubicin dox loaded cpd nps high efficiency showing typical reduction dual responsive release profiles flow cytometric analysis confocal laser scanning microscopy clsm confirmed dox loaded cpd nps could internalized cancer cell efficiently release dox intracellular environment furthermore cell cytotoxicity assays indicated cpd nps good biocompatibility toward cancerous normal cells dox loaded cpd nps exhibited significant inhibition cell proliferation various cancer cells therefore biocompatible cpd may great potential intracellular drug delivery clinical cancer therapy elsevier inc rights reserved
empirically based modeling essential aspect design wave energy converter empirically based models used structural mechanical control design processes well performance prediction design experiments methods used system identification strong impact quality resulting model study considers system identification model validation process based data collected wave tank test model scale wave energy converter experimental design data processing techniques based general system identification procedures discussed compared practices often followed wave tank testing general system identification processes shown number advantages including increased signal noise ratio reduced experimental time higher frequency resolution experimental wave tank data used produce multiple models using different formulations represent dynamics wave energy converter models validated performance compared one another models wave energy converters use formulation surface elevation input study shows model using hull pressure measurement incorporate wave excitation phenomenon better accuracy
electrical domain equalization chromatic polarization mode dispersion attractive coherent optical communication links digital coherent receivers used purpose based high speed adcs followed dsp dissipate excessive amount power costly implement propose analog coherent receiver drastically reduce power consumption size cost adaptive feed forward equalizer gbps dual polarization quadrature phase shift keying qpsk systems processes signals analog domain demonstrated using circuit system simulations equalizer designed cmos technology consumes power occupies chip area system simulations used show blind equalization also possible approach used decision directed mode
background niemann pick disease type rare inherited neurodegenerative disease impaired intracellular lipid trafficking clinical symptoms highly heterogeneous including neurological visceral psychiatric manifestations incidence estimated due recognition misdiagnosis across wide range medical fields new screening diagnostic methods provide opportunity improve detection unrecognized cases clinical sub populations associated higher risk patients risk groups clinical niches symptoms potentially related unrecognized due prevalent clinical features lack awareness regarding underlying metabolic causes methods twelve potential clinical niches identified clinical experts evaluated based comprehensive non systematic review literature published date relevant publications identified targeted literature searches embase pubmed using key search terms specific niche articles published english european languages included findings several niches found relevant based available data movement disorders early onset ataxia dystonia organic psychosis early onset cholestasis hepato splenomegaly cases relevant antenatal findings fetal abnormalities patients affected family history consanguinity endogamy potentially relevant niches requiring supportive data included early onset cognitive decline frontotemporal dementia parkinsonism chronic inflammatory cns disease relatively weak evidence suggest amyotrophic lateral sclerosis progressive supranuclear gaze palsy potential niches conclusions several clinical niches identified harbor patients increased risk
study asks highly identified sports fan feel strong bond watching favorite football players exhibit violent copycat behavior using media copycat framework research looked five categories domestic violence arrests city philadelphia eagles gamedays period beginning kick time relationships tested using comparison means tests mean average domestic violence arrests football statistically significantly different comparison sundays sports gamedays predicted statistically significant difference home away games removing possible bias fans game became violent
objectivesnew research informed methods case conceptualization cut across traditional therapy approaches increasingly popular paper presents trans theoretical approach case formulation based research observations emotion methodsthe sequential model emotional processing pascual leone greenberg process research model provides concrete markers therapists observe emerging emotional development clients illustrate model used clinicians track change provides clinical map therapist may orient session plan treatment interventions resultsemotional processing offers trans theoretical framework therapists wish conduct emotion based case formulations first present criteria research model translates well practice second two contrasting case studies presented demonstrate method conclusionsthe model bridges research practice using client emotion axis integration key practitioner message process research emotion offer template therapists make case formulations using range treatment approaches sequential model emotional processing provides process map concrete markers therapists observe emerging emotional development clients help therapists develop treatment plan copyright john wiley sons ltd
data structures algorithms central part computer science due abstract dynamic nature difficult topic learn many students alleviate learning difficulties instructors turned algorithm visualizations systems research shown especially engaging avs impact student learning dsa topics recently systems java based systems popularity java declined supplanted html javascript content online paper present jsav javascript development library jsav goes beyond traditional library support displaying standard data structures components provide functionality simplify creation avs many engagement levels including interactive exercises describe growing body content created jsav summarize three years experience research results using jsav build content supports education
background aims efficacy nsa inhibitors treatment patients chronically infected hepatitis virus hcv affected presence nsa resistance associated substitutions rass analyzed data phase iii studies countries determine pretreatment prevalence various nsa rass effect outcomes treatment ledipasvir sofosbuvir patients genotype hcv methods nsa gene deep sequencing analysis performed samples patients gilead clinical trials effect baseline rass sustained virologic response svr rates assessed patients treated regimens containing ledipasvir sofosbuvir results using cut pretreatment nsa ledipasvirspecific rass detected genotype patients respectively patients genotype among genotype treatment naive patients svr rates without ledipasvirspecific rass respectively among treatment experienced genotype patients svr rates without ledipasvir specific rass respectively among treatment naive genotype patients svr rates without ledipasvir specific rass among treatment experienced genotype patients svr rates without ledipasvir specific rass respectively conclusions pretreatment ledipasvir specific rass present patients impact treatment outcome patient groups particularly treatmentexperienced patients genotype hcv lay summary efficacy treatments using nsa inhibitors patients chronic hepatitis virus hcv infection affected presence nsa resistance associated substitutions rass reviewed results clinical trials patients genotype hcv infection received treatments included ledipasvir sofosbuvir determine prevalent nsa rass patients baseline found ledipasvir specific rass present patients prior treatment negative impact treatment outcome subset patient groups particularly treatment experienced patients genotype hcv european association study liver published elsevier rights reserved
search based techniques applied successfully task generating unit tests object oriented software however meta heuristic search efficiency heavily depends many factors seeding refers use previous related knowledge help solve testing problem hand one factor may strongly influence efficiency paper investigates different seeding strategies unit test generation particular seeding numerical string constants derived statically dynamically seeding type information seeding previously generated tests understand effects seeding strategies results large empirical analysis carried large collection open source projects corpus apache commons repository reported experiments show strong statistical confidence even testing tool already able achieve high coverage use appropriate seeding strategies improve performance authors software testing verification reliability published john wiley sons ltd
objectives ambulance services stroke alerts reduce time stroke onset acute stroke diagnosis describe use stroke alerts ambulance services different hospitals patient groups relationship reperfusion therapy methods nationwide study included patients admitted acute stroke registered swedish stroke register riksstroke results proportions patients admitted stroke alerts acute stroke admissions varied university hospitals specialized nonuniversity hospitals community hospitals younger age atrial fibrillation living institution reduced consciousness upon admission hemorrhagic stroke factors associated higher probability stroke alerts living alone primary school education non european origin previous stroke diabetes smoking dependency activities daily living adl associated lower probability stroke alert proportion patients arriving hospital ambulance varied older age living alone primary school education born european country previous stroke dependency adl living institution reduced consciousness upon admission hemorrhagic stroke associated ambulance services hospital stroke alert frequencies correlated strongly reperfusion rates conclusion acute stroke alerts significant potential improve stroke reperfusion rates prehospital stroke management varies conspicuously hospitals patient groups elderly patients living alone markedly reduced likelihood stroke alerts
paper ddes delayed detached eddy simulation applied study spanwise suction control effect wind induced effect static bridge deck isolated suction holes arranged lower surface test model spanwise direction based previous studies similar bluff body proper distance spanwise suction chosen trigger amplify unstable secondary instability mode wake simulation results show suction arranged close wake best control effect reducing fluctuating aerodynamic forces due mean velocity modification isolated spanwise suction virtual aerodynamic shape modification generated could act spanwise perturbation suppress spanwise vortexes results indicate spanwise suction could trigger amplify mode instability hence lead dislocation spanwsie vortex even completely suppress spanwise vortex addition spanwise suction control surpress spanwise vortex shedding wide range elsevier ltd rights reserved
little full scale physical experimentation support findings numerous computational studies regarding contribution various substructure components overall bridge foundation system behavior response lack experimental data field testing program undertaken investigate situ dynamic characteristics long three span precast concrete bridge forced vibration testing system identification used characterize dominant modal behavior bridge foundation system loading direction leading identification likely force transfer mechanisms structure substructure components determined transverse longitudinal responses bridge dominated abutment stiffness passive resistance buried settlement slab contributing significantly transverse response backfill passive resistance dominating longitudinal response
fibrosis complex chronic disease characterized persistent repair response pathogenesis poorly understood typically result chronic inflammation maintained required activity transforming growth factor beta tgf beta extracellular matrix ecm tension drive fibroblasts transition myofibroblast phenotype effector cells repair myofibroblasts migrate site injury deposit excessive amounts matrix proteins stimulate high levels contraction myofibroblast activity decisive factor whether tissue properly repaired controlled wound healing rendered fibrotic deregulated repair extensive studies documented various contributing factors abrogated repair response though fibrotic factors known little understood opposing antifibrotic molecules assist successful repair prostaglandin pge ecm retraction following review discuss general development fibrosis transformation myofibroblasts focusing primarily prominent profibrotic pathways tgf beta ecm tension antifibrotic pathways pge ecm retraction idea understand ways cell injury inflammatory response normally controls repair mechanisms homeostatic regulators mimic therapeutically control abnormal pathways
problem realizing arbitrary transfer functions combinations positive filters general representing arbitrary systems means internally positive representations iprs widely investigated discrete time framework ipr positive state space representation endowed input state output transformations realizes arbitrary input state output dynamics technical note investigates problem ipr construction continuous time systems proposes technique provides stable iprs particular class systems
optimal placement wireless sensors different conventional wired sensor placement due limited transmission range wireless sensors constraint inter sensor distance makes optimization problem difficult solve conventional gradient based methods paper improved generalized genetic algorithm gga based self adaptive dynamic penalty function sadpf proposed optimal wireless sensor placement owsp bridge vibration monitoring mathematical model owsp problem established considers bridge vibration monitoring requirements constraints data transmission range wireless sensor networks wsns sadpf automatically adjust amount penalization constraint violations according evolution generation number degree violation developed wireless sensor placement optimized using gga subsequently gga improved implementing elite conservation strategy worst elimination policy dual structure coding system finally numerical experiment presented long span suspension bridge demonstrate feasibility efficiency proposed method indispensible discussions also given results indicate wireless sensor configurations optimized improved sadpf based gga simultaneously meet data transmission demands wsn fulfill requirements structural condition assessment developed sadpf minimize influence limited data transmission range search process owsp improved sadpf based gga quickly robustly converges global optimal solution
arsenic contamination drinking ground water reached alarming situation parts bengal delta india development methods removal arsenic contamination drinking water great importance mankind main objective study isolate characterize arsenic resistant bacteria arb surface water kabar wetland located begusarai district bihar province degrees degrees india bacteria isolated water sample enrichment culture technique based rrna gene sequences isolates tolerating arsenate identified paracoccus strain alcaligenes faecalis strain whereas isolate resistant arsenite lll identified stenotrophomonas strain bioinformatic analysis genome reference strains revealed presence different arsenic resistance ars genes arsenic removal efficiency isolates evaluated observed resistant strains paracoccus alcaligenes removed arsenic respectively external growth medium whereas resistant strain stenotrophomonas removed arsenic culture broth optimum temperature nutrient levels peptone water arsenic removal isolates degrees respectively observations suggest strains described study capable removing arsenic dilute solutions hence natural isolates strains easily used purification arsenic contaminated water thereby check increasing arsenic toxicity human food chain
study aimed evaluate nutritional value proximate fatty acid profiles vitamins minerals also nutritional quality indices nqi orange spotted grouper epinephelus coioides prepared according common consumer techniques raw poached steamed microwaved pan fried deep fried olive oil increase protein lipid ash contents cooked fish compared raw fish fillets cooking treatment significant effect total fatty acids except deep fried fillets cooking methods significant effect total fatty acids cooking methods fatty acids well preserved significant difference contents fillet raw cooked samples vitamin content cooking methods differ significantly none cooking methods significant effect vitamin except deep frying fillets however vitamin contents cooked fish significantly decreased considering overall nutritional quality indices vitamin mineral contents steaming best cooking method
conformal immersions harmonic numerically stable surfaces whose tangents scale isometrically providing many elegant geometric properties use design paper maps forms within context discrete differential geometry conformal geometric algebra order outline approach synthesizing curved surfaces applications architectural geometry machining computer graphics inspired dorst valkenburg square root logarithm rotors paper reformulate rationalization cyclidic nets piecewise smooth surfaces characterized controlled directly tangents
background obstructive sleep apnea osa common disorder worldwide however epidemiological studies prevalence lack saudi arabia study aimed determine prevalence risk factors osa saudi arabia methods study performed two stages screening stage first random sample saudi employees years age completed survey included wisconsin questionnaire according data subjects categorized habitual moderate nonsnorers nss confirmatory second stage case control study conducted individuals selected group using polysomnography psg results first stage prevalence habitual snoring moderate snoring sample nss among individuals underwent psg total subjects osa apnea hypopnea index ahi osa syndrome osas defined ahi plus daytime sleepiness clinically diagnosed osa syndrome cosas defined american academy sleep medicine conservative estimate least men women calculated overall prevalence osa similarly overall estimated prevalence osas cosas men women men women respectively multivariate analysis revealed age gender obesity hypertension independent risk factors osa conclusions study demonstrated rate risk factors osa saudi population similar observed western studies
paper conduct research construction optimization approaches housing construction process control system based enterprise resources planning system data analysis model housing construction project construction process multifarious handover work also lot construction process often comprehensively deal quality progress cost cost various aspects must scientific effective measures means realize optimization construction management control project cost guarantee construction quality progress pivotal role elaborates content article management building construction understanding building construction main problems mainly put forward corresponding optimization management measures order promote perfection country housing construction progress combining data analysis model optimize traditional erp system enhancement
anterior temporal lobes atls consistently associated semantic processing turn key role reading aloud single words study aimed investigate reading abilities patients semantic variant primary progressive aphasia svppa relationship gray matter volume left atl word reading performance using voxel based morphometry vbm three groups participants svppa alzheimer disease healthy elderly adults performed reading task exception words regular words pseudowords along structural magnetic resonance imaging scan exception words svppa group lower accuracy greater number regularization errors compared control groups healthy participants patients similarly regular words svppa patients lower accuracy comparison patients greater number errors related complex orthography phonology mappings opm comparison control groups vbm analyses revealed volume left atl associated number regularization errors also volume left lateral atl associated number errors complex opm regular word reading results suggest left atl might play role reading exception words accordance role semantic processing results support involvement left lateral atl combinatorial processes including integration semantic phonological information exception regular words
flow induced motions fims rigid circular cylinders particularly viv vortex induced vibrations galloping induced alternating lift vivace viv aquatic clean energy converter uses single multiple cylinders tandem elastic end supports synergistic fim convert mhk energy electricity selectively distributed surface roughness applied enhance fim increase efficiency paper two cylinders used tandem center center spacing diameters harnessing damping ratio zeta reynolds number virtual spring damping system marine renewable energy laboratory mrelab enables embedded computer controlled change viscous damping spring stiffness fast mathematically correct oscillator realization without including hydrodyllamic force closed control loop experimental results oscillatory response energy harvesting efficiency presented envelope optimal power derived experiments conducted low turbulence free surface water ltfsw channel mrelab university michigan main conclusions tested cylinder spacing two cylinders harness power times power single cylinder efficiency two cylinders single cylinder mhk power harnessed upstream cylinder increased affected downstream cylinder mhk power harnessed downstream cylinder fim affected lesser extent interaction vivace harness energy flows slow upper limit flow velocity close spacing high spring stiffness yield highest harnessed power optimal harnessed power shifts softer springs spacing increases elsevier ltd rights reserved
help clinicians segment borders left ventricle efficiently measurement heart authors come semi automatic approach study capable identifying endocardial borders robustly cine magnetic resonance images firstly deformation flow computed inputted boundary previous frame extracted edge current frame based boundary minimum distance principle bmdp deformation flow constrained optical flow calculated partial differential equation model smooth deformation boundary formed minimising energy previously inputted boundary rough boundary obtained bmdp optical flow constraint extract edge accurate possible threshold selection method used improved based previous study proposed approach tested open access dataset computed average perpendicular distance computed dice measure experimental results show proposed approach significantly accurate referenced state art methods
introduction primary headaches impact substantially daily activities sufferers leading increased direct indirect medical burden sufferers growing public health problem affecting estimated africans yet among young nigerians disorder remains underestimated scope scale recognized treated methods questionnaire bases cross sectional study conducted enugu south east nigeria frequency headache pain intensity accessed questions midas questionnaire precipitating factors drugs used medical consultation academic limitation also assessed results total students interviewed lifetime prevalence primary headache corresponding prevalence migraine tension type headache respectively unlike migraine tension type headache significantly higher females headaches lasted days primary headaches migraine tth similar males females proportion students worried headache attacks compared primary headaches consulted physician whose academic performance often affected limitation academic performance significantly higher among students received medical consultation students worried attacks conclusion primary headaches common among secondary school children enugu south east nigeria nigeria headaches last days frequently limit academic activities sufferers sources concern sufferers
objectives study evaluates whether certain patient parental characteristics associated gastroenterology referral versus primary pediatrics care pediatric irritable bowel syndrome ibs methods retrospective clinical trial sample patients meeting pediatric rome iii ibs criteria assembled single metropolitan health care system baseline socioeconomic status ses clinical symptom measures gathered various instruments measured participant parental psychosocial traits study outcomes stratified referral versus primary pediatrics care two separate analyses ses measures clinical symptoms psychosocial measures identified key factors univariate multiple logistic regression analyses analysis identified factors placed unadjusted adjusted multivariate logistic regression models assess impact predicting referral results participants referred pediatric managed primary pediatrics care ses clinical symptom factors child self assessment abdominal pain duration lower percentage people living poverty strongest predictors referral among psychosocial measures parental assessment child functional disability sole predictor referral multivariate logistic regression models selected factors continued predict referral model conclusions socioeconomic environment clinical symptoms functional disability associated referral future interventions designed ameliorate effect identified factors could reduce unnecessary specialty consultations health care overutilization ibs
electric vehicles promising way reduce greenhouse effect researched extensively improvements areas power electrics energy storage support plug hybrid electric vehicle phev provides competitive driving range fuel economy compared internal combustion engine vehicle icev operating optimised control strategies utilising concept energy management system ems efficiency phev could significantly improved review paper operating process various types evs explained battery technology supercapacitor technology also discussed possibility increase energy capacity phev
development supervisors behaviours proposed innovative approach reduction employees work stress health safety executive hse developed stress management competency indicator tool smcit designed used within learning development intervention however psychometric properties never evaluated length questionnaire items limits practical applicability developed brief item version questionnaire assessed psychometric properties studied relationship employees psychosocial work environment employees filled brief smcit stress management indicator tool latter self report questionnaire developed hse measuring workers perceptions seven dimensions psychosocial work environment properly managed lead harm data analysed structural equation modelling multiple regressions results confirmed factorial structure brief smcit questionnaire mainly supported convergent validity internal consistency scales furthermore exceptions relations hypothesized supervisors competencies psychosocial work environment confirmed supporting criterion validity revised questionnaire hse framework conclude brief item version smcit represents important step toward development interventions directed supervisors discuss practical implications work stress prevention
future world micro nano dimensions leading generation whole new range products particularly engineered medical healthcare diagnostics industrial optical telecommunications aerospace applications textiles many current manufacturing processes based lithographic techniques traditionally driven silicon micro production new drive low cost high precision products greater functionality based non silicon materials polymers ceramics glass metals machining micro nano structures non silicon materials requires new process technologies developed new facilities manufacturing engineering centre cardiff university known microbridge facilities provide open access micro nano engineering manufacturing service industry provides suite equipment facilities based focused ion beam milling machine picosecond laser ablation system nano imprinting lithograph complement already established range micro machining equipment
impact childhood maltreatment effects extend beyond immediate stress abusive family environments college students exposed childhood domestic violence parental physical abuse expected viewed less favorably peers nonabused counterparts expected well less accurate predicting first impressions left peers minute unstructured interactions partial support found hypotheses relatively harsher peer first impressions found among domestic violence witnesses domestic violence parental physical abuse victims overestimated peer ratings social anxiety peer interactions higher among women exposed either form childhood maltreatment men violent families viewed less favorably peers results implicate childhood maltreatment contributing factor peer distancing rejection
background aims infliximab adalimumab increasingly used prevent postoperative recurrence crohn disease patients impact previous exposure one anti tumour necrosis factor tnf agents surgery efficacy anti tnf therapy postoperative recurrence unknown methods performed retrospective analysis crohn disease patients underwent surgical bowel resection anastomosis prophylactic treatment anti tnf therapy january june results total consecutive crohn disease patients bowel resection anastomosis followed prophylactic treatment anti tnf included patients previous exposure one one anti tnf agents respectively patients surveillance colonoscopy cumulative rates postoperative endoscopic recurrence years patients exposed two anti tnf alpha compared patients exposed one zero anti tnfa surgery cumulative rates clinical recurrence year patients exposed two anti tnfa compared patients exposed zero one anti tnf alpha surgery multivariable analysis identified smoking previous exposure two anti tnfa risk factors crohn disease clinical endoscopic postoperative recurrence hazard ratio confidence interval respectively conclusions previous exposure two anti tnf agents associated higher risk postoperative recurrence crohn disease patients
yellow nail syndrome yns omim orpha rare disorder almost always occurs years age juvenile familial form also observed yns diagnosed based triad associating yellow nail discoloration pulmonary manifestations chronic cough bronchiectasia pleural effusion lower limb lymphedema chronic sinusitis frequently associated triad yns etiology remains unknown role lymphatic impairment usually evoked yns frequently isolated may associated rare cases autoimmune diseases clinical manifestations implicating lymphatic functions cancer hence also considered paraneoplastic syndrome yns management symptomatic codified yns resolve spontaneously oral vitamin alone even better associated triazole antifungals may achieve partial total disappearance nail discoloration pleural effusion treated surgically decortication pleurectomy pleurodesis antibiotic prophylaxis prescribed bronchiectasia chronic sputum production lymphedema treatment based low stretch bandages wearing elastic compression garments combined skin care exercises needed manual lymph drainage
correspondence set mappings establishes relation elements two data structures sets points strings trees graphs consider several correspondences two structures one option define representative generalised median correspondence general computation generalised median complete task paper present two methods calculate generalised median correspondence multiple correspondences first one obtains optimal solution cubic time restricted hamming distance second one obtains sub optimal solution iterative approach restrictions respect used distance compare proposals terms distance true generalised median runtime
one anastomosis gastric bypass oagb demonstrated results similar traditional roux procedures terms weight loss resolution obesity related comorbidities main controversy regarding oagb concern association biliary alkaline gastritis esophageal gastric cancer raised studies present case year old woman bmi underwent laparoscopic oagb one year later consulted recurrent heartburns upper endoscopy showed pouchitis bile reflux esophagus medical treatment gastroesophageal reflux disease ineffective decided convert oagb roux gastric bypass rygb video show revise oagb treat chronic bile reflux converting procedure standard rygb intervention starts restoring normal anatomy small bowel resection gastrojejunal anastomosis located treitz ligament gastric pouch created standard roux gastric bypass performed resection gastrojejunal anastomosis allows fashioning roux limb classical measures technique allows conversion standard rygb effective treating biliary reflux
telomeres dynamic nucleoprotein dna structures cap protect linear chromosome ends several monogenic inherited diseases display features human premature aging correlate shortened telomeres referred collectively telomeropathies disorders overlapping symptoms common underlying mechanism telomere dysfunction also exhibit variable symptoms age onset suggesting fall along spectrum disorders primary telomeropathies caused defects telomere maintenance machinery whereas secondary telomeropathies overlapping symptoms primary telomeropathies generally caused mutations dna repair proteins contribute telomere preservation review primary secondary telomeropathies discuss potential mechanisms tissue specificity age onset highlight outstanding questions field future directions toward elucidating disease etiology developing therapeutic strategies elsevier rights reserved
perivascular adipose tissue pvat surrounds blood vessels releases paracrine factors cytokines regulate local inflammation inflammatory state pvat important role vascular disease pro inflammatory state related atherosclerosis development whereas anti inflammatory one protective cold exposure beneficially affects immune responses could thus impact pathogenesis cardiovascular diseases study investigated effects one week cold exposure degrees ferrets aortic pvat apvat versus subcutaneous adipose tissue ferrets used similarity adipose tissues humans ferret specific agilent microarray designed cover complete ferret genome global gene expression analysis performed data showed cold exposure altered gene expression mainly apvat regulated genes associated cell cycle immune response gene expression regulation mainly regulated regarding effects immune response cold acclimation decreased expression genes involved antigen recognition presentation cytokine signalling immune system maturation activation immunosuppressive gene expression pattern depot specific observed inguinal subcutaneous depot interestingly depression immune response related genes also evident peripheral blood mononuclear cells pbmc conclusion results reveal cold acclimation produces inhibition immune response related pathways apvat reflected pbmc indicative anti inflammatory response potentially exploited enhancement maintenance cardiovascular health
paper presents design process measurement results shunted piezoelectric isolator good compromise solely passive active isolator system used reduction vibration transmission two idealized panels plane fuselage design process numerical models panel structure shunted isolator used order derive reduced state space matrices based modal superposition numerical models describe dynamic behaviour components integrated simulation environment holistic system required modal data derived experimental numerical modal analyses panel means analytical description geometry shunted piezoelectric isolator automatically optimized defined goal parameters applying impedance admittance simulation approach isolator shunt circuit modeled using simulation environment configuration performance shunt investigated adjusted hardware realization shunted isolator examined test setup results test measurements compared simulation results system finally two shunted isolators placed fuselage panel ideal mass measurement results show vibration reduction potential semi passive system addition solely passive isolation effect paper indicates feasibility shunted piezoelectric elements addition passive isolation system furthermore effective preliminary design strategy layout shunted piezoelectric isolators presented compared measurement results
introduction national conference didactic lectures traditionally featured hour long lecture based presentations however evidence longer lectures lead decreased attention retention information authors sought identify trends lecture duration lecture types number speakers four national emergency medicine conferences year period methods authors performed retrospective analysis length number speakers format didactic lectures four different national conferences years authors abstracted data national academic assemblies four largest profit organizations united states american academy emergency medicine american college emergency physicians council emergency medicine residency directors society academic emergency medicine results significant yearly decrease mean lecture lengths three four conferences increase percentage rapid fire sessions preceding years corresponding decrease percentage general educational sessions significant difference mean number speakers per lecture discussion analysis didactic lecture sessions annual meetings four national organizations year period showed significant decreases mean lecture length findings help guide continuing medical education conference planning research
variety biomedical applications nanoparticles used drug carriers anti tumor agents biosensors modulators immune response full scale real clinical application nanomaterials requires great deal information safety biotoxicity even traditionally harmless materials like gold obtain toxic features scaled nanosize vitro studies showed nanoparticles geno cytotoxic effects body whole remain largely mystery shed light study focused reproductive toxicity nanomaterials synthesized gold nanoparticles reduction sodium tetrachloroaurate iii alkaline medium addition sodium polyphosphate stabilizing agent next particles administered intraperitoneally young old rats days test functional capabilities testes injected kisspeptin antagonist peptide intracerebroventricularly substances known stimulate inhibit central component hypothalamic pituitary gonadal axis respectively routine histological procedures measured diameter seminiferous tubules nuclear cross sectional area sertoli cells markers testicular spermatogenic activity cross sectional area leydig cells nuclei marker testicular steroidogenesis found injections nanogold caused significant changes young animals time morphometric parameters adult animals significantly lower compared control although observed pathological changes tissue combined administration gold nanoparticles kisspeptin showed stimulatory effect latter observed specific feature toxicants called endocrine disruptors moreover found morphological signs testicular degeneration characteristic low testosterone state simultaneous injections gold peptide resulted highest degree testicular functional downregulation regardless age taken whole data indicates gold nanoparticles disrupt regulatory network hypothalamic pituitary gonadal axis possibly due direct action interstitial cells spermatogenic epithelium
urinary incontinence disproportionately affects women anatomical textbooks typically describe continence mechanisms women context pelvic floor support urinary bladder urethral sphincters however urinary bladder urethral sphincters central control brain complex network neurons allow storage urine followed voiding socially appropriate recent studies suggest common type urinary incontinence women urgency urinary incontinence involves significant dysfunction central control micturition paper review anatomy functional connectivity nervous system structures involved control micturition clinical application anatomy context urgency urinary incontinence also discussed understanding anatomy neural structures control continence allow clinicians better understand underlying pathology urge incontinence consider new ways treating distressing condition clin anat wiley periodicals inc
information quality rural drinking water sources used manage safety mitigate risks health sanitary surveys observational checklists assess hazards present water sources simpler conduct microbial tests assessed whether sanitary survey results associated measured indicator bacteria levels rural drinking water sources kisii central kenya overall thermotolerant coliform ttc levels high samples tested dug wells almost samples tested springs samples tested rainwater harvesting systems contaminated ttc significant associations ttc levels overall sanitary survey scores individual components contamination ttc associated source type dug wells springs contaminated rainwater systems sanitary surveys substituted microbial water quality results context could used identify potential hazards contribute comprehensive risk management approach
dynamics two coupled dissipatively perturbed near integrable hamiltonian double well duffing oscillators studied give numerical experimental circuit implementation evidence case small positive negative damping exist two different types transient chaos decay transient chaos neighborhood chaotic saddle observe transient chaos neighborhood unstable tori argue results robust exist wide range system parameters elsevier rights reserved
backgroundzirconia abutments introduced restore esthetic regions showed sufficient stability support implant restorations nonetheless date observation periods shorter titanium abutments purposeto assess survival implant crowns supported computer aided design computer aided manufacturing cad cam abutments years materials methodsfifty six patients selected prospective clinical study patient received least titanium implant total fixtures two stage surgical technique additional soft hard tissue graft used implants randomly divided groups receiving different cad cam abutments titanium titanium nitride zirconia zirconia metal ceramic crowns used final restorations cementation baseline restorations checked months years assessing mechanical complication statistical analyses performed evaluate year success rates resultsfive failures reported zirconia group failed restorations showed fractures abutment connection four failures occurred posterior regions one occurred screwing abutment titanium titanium nitride abutments significantly higher year success rates zirconia abutments conclusionsatlantis titanium titanium nitride abutments showed optimal clinical performances years conversely atlantis zirconia abutments avoided restore posterior regions
paper presents fully coupled multiphysics model developed numerical simulation elastohydrodynamically lubricated contact cam roller typically found cam mechanisms controlling fuel injection internal combustion engine special attention focused enabling systematic analyses effects associated roller crowning edge geometries lubricant rheology well typical cam mechanism operating conditions interaction cam roller follower result high generated pressure narrow film thickness increase risk wear fatigue furthermore article highlights variation pressure film thickness tilting conditions model also validated particular model problems found literature authors published elsevier ltd
integrated gmr giant magneto resistance angle sensor presented designed fulfill requirements electrical commutated motor drives motors use sine commutation coils need angle motor shaft accuracy ranges degrees update rates integrated gmr angle sensor solves problem using integrated gmr angle sensors top silicon signal processing chip differential gmr bridge signals converted digital domain sigma delta adcs raw signals error compensated additional autocalibration feature implemented improve accuracy operation fast angle measurement performed using parallel analog signal processing mhz finite state machine dedicated peripherals mbit spi interface additional feature reduce time delay implemented angle value prediction built selftests switchable voltages signal path tests multiple safety voltage comparators implemented safety critical applications published elsevier ltd
purposeepidemiological studies asthma adolescence commonly rely self reports study aimed compare adolescent parent reports regarding presence asthma asthma symptoms two ethnic groups jews arabs living country methodseighth grade pupils attending five schools tel aviv four schools two arab cities israel asked complete self report international study asthma allergies childhood isaac questionnaire classroom parents interviewed telephone using parental isaac questionnaire assessed prevalence rates asthma asthma symptoms according adolescent parent responses agreement adolescents parents assessed cohen kappa coefficient resultsadolescents reported asthma asthma symptoms parents jewish adolescent parent pairs arab adolescent parent pairs groups groups showed moderate adolescent parent chance corrected agreement current asthma kappa jews arabs lifetime asthma kappa jews arabs slight fair chance corrected agreement asthma symptoms statistically significant differences jewish arab populations chance corrected agreement parameters assessed conclusionsjewish arab adolescents often report asthma asthma symptoms parents seems cross cultural phenomenon therefore particular attention paid source information comparing prevalence asthma asthma symptoms across studies pediatr pulmonol wiley periodicals inc
sociological interpretation empirical outcomes studies violent media draws debate beyond realm individual psychological effects identifies pertinent social groupings beyond socioeconomic status five attributes identify special vulnerability negative influence predisposition aggressive antisocial behavior rigid indifferent parenting unsatisfactory social relationships low psychological well diagnosed suffering dbds disruptive behavior disorders interpretation effect sizes derived seven meta analyses encompassing different forms media violence resultant different varieties aggressive antisocial behavior supports robust hypothesis media influence causation implied outcomes pooled experimental survey designs consistent across aggregations media take role oppressors underclass limited access opportunities improvement
fuzzy trace theory distinguishes verbatim literal exact gist meaningful representations predicting reliance gist increases experience expertise thus many judgment decision making biases increase development cognition colored context ways violate logical coherence probability theories nevertheless increase gist based intuition adaptive gist stable less sensitive interference easier manipulate moreover gist captures functionally significant essence information supporting healthier robust decision processes describe fuzzy trace theory accounts judgment decision making phenomena predicting paradoxical arc processes development experience expertise present data linking gist memory processes gist processing decision making provide illustrations gist reliance medicine public health intelligence analysis report first evidence predicted link false memory framing biases risky choice society applied research memory cognition published elsevier inc rights reserved
paper three groove semi kinematic mounting designed analyzed stability micro milling operational conditions employed specific modular reconfigurable micro factory test bed developed authors group various kinds kinematic couplings popular high repeatability interchangeability considered modular machine design gothic arch maxwell coupling designs compared evaluation process first maximum preload resist induced contact stresses determined static stiffness matrices evaluated case compared measure relative stability maxwell coupling found best adopted machine stage experiments performed know coupling stability varying load
study examined relationship physical activity chronic diseases european older adults using prospective analysis data participants older adults men responded fourth fifth wave share project european countries participants answers interview questions presence chronic conditions cross sectional prospective association number chronic diseases assessed using general linear models among men women moderate vigorous physical activity mvpa associated fewer reported chronic diseases prospective analysis mvpa inversely associated number chronic diseases unadjusted model adjusted model mvpa week remained significant predictor fewer chronic diseases prescribed older adults order prevent reduce number chronic diseases possible vigorous intensity recommended
generalized anxiety disorder gad characterized pervasive highly distressing anxiety worries associated severe impairment although numerous agents various drug classes available treat gad many patients inadequate response constituting important medical frontier face challenge new pharmacological alternatives need studied aiming clinical improvement better quality life patients assess efficacy pregabalin pgb compared placebo amelioration anxiety symptoms patients gad systematic literature search performed using databases medline embase sources main outcome hedges continuous scores used random effects model heterogeneity evaluated moderate heterogeneity assumed high heterogeneity chi test heterogeneity publication bias evaluated using funnel plot meta regression performed using random effects model safety evaluation compared patients dropout rates included eight randomized controlled trials study comparing use pgb different dosages placebo terms main outcome pgb found superior placebo group hedges confidence interval funnel plot assessment showed low risk publication bias study heterogeneity significant strengthening results meta regression showed particular influence variable results categorical analysis safety using dropout severe possible outcome carried difference pgb placebo groups observed terms dropout rates pgb superior placebo amelioration gad symptoms addition dropout rate significantly higher placebo groups pgb comparable benzodiazepines clinical response lower dropout rates benzodiazepine copyright wolters kluwer health inc rights reserved
disparities health mental health sexual minority heterosexual individuals emerge early adolescence large part sexual minority individuals stigmatized article review synthesize role gender nonconformity shaping adolescents experience stigma associated sexual minority status review research adolescents emerging adults shows gender nonconformity associated variation harassment mental health outcomes within sexual minority groups sexual minority heterosexual groups next discuss gender nonconformity construct influences association sexual minority status peer relations peer relations individual psychosocial outcomes finally discuss importance addressing stigma related gender nonconformity
introduction overall goal alzheimer disease neuroimaging initiative adni validate biomarkers alzheimer disease clinical trials adni began august year renewal current adni study methods adni follow current additional subjects normal cognition mild cognitive impairment using innovative technologies tau imaging magnetic resonance imaging sequences connectivity analyses highly automated immunoassay platform mass spectroscopy approach cerebrospinal fluid biomarker analysis systems biology pathway approach used identify genetic factors subject selection enrichment amyloid positron emission tomography scanning standardized using centiloid method brain health registry help recruit subjects monitor subject cognition results multimodal analyses provide insight pathophysiology disease progression discussion adni aim inform treatment trials facilitate development disease modifying treatments alzheimer association published elsevier inc rights reserved
paper mainly discusses application operational research models construction project management quantifying actual problems tender management material procurement management design management construction management apply operational research models obtain optimal solution problem also discusses development improvement operational research models construction project management innovation point article lies quantification practical problems management construction projects use mathematical model solve practical problems
series zinc phosphate glass containing different concentrations napo zno mol prepared melt quenching method analyzed differential scanning caloremetry dsc impredance spectroscopy electrical properties samples measured using impedance spectroscopy technique frequency range mhz several temperatures range conductivity conductivity dielectric constant loss factors obtained measurements constant phase elements cpe used equivalent electrical circuits fitting experimental impedance data impedance spectra also indicated conduction predominantly polaronic nature frequency temperature dependence electrical modulis well dielectric loss parameters exhibited relaxation character attributed vanadyl complexes relaxation effects analyzed graphical method analysis established spread relaxation times results discussed quantitatively light different valance states vanadium ions aid data spectroscopic properties frequency dependence electric conductivity found follow simple power law behavior accordance relation sigma omega sigma lambda omega smaller thermal activation energies electronic conduction estimated basis arrhenius plots published elsevier
main aim paper show logical method obtain fully electronically adjustable active filter electronic control type transfer function without change topology change input excitation reconnection output important chip applications especially results synthesis demonstrated biquadratic filter band reject pass response structure two equivalent solutions introduced discussed achievable features confirmed pspice simulations
background fungal infections central nervous system ficns important causes morbidity mortality among immunocompromised pediatric patients standard diagnostic modalities lack sensitivity detecting therapeutically monitoring life threatening diseases current molecular methods remain investigational beta glucan bdg cell wall component found several fungal pathogens including candida aspergillus spp detecting bdg cerebrospinal fluid csf may important approach detecting therapeutically monitoring ficns date study investigated effectiveness csf bdg diagnostic therapeutic marker ficns children methods serial bdg levels measured serum csf samples obtained pediatric patients aged years diagnosis probable proven candida aspergillus cns infection results nine cases ficns identified patients aged month years two patients infected aspergillus species patients infected candida species patients baseline detectable bdg csf among patients completed therapy ficns elevated csf bdg levels decreased time writing patient still receiving therapy continued elevated bdg levels one patient died overwhelming disseminated candidiasis lengths therapy children ranged weeks months conclusion bdg assay useful diagnosing therapeutically monitoring candida aspergillus cns infections pediatric patients
paper describes general model hybrid excited synchronous machine multiple voltage levels generated phase stator system voltage behind reactance formulation different voltage level phase stator system realized machine design rotor excited excitation winding permanent magnet model incorporates magnetic saturation main inductance magnetic electric coupling phases field winding mechanical displacement angle cross coupling axes main inductances included constant saliency factor saturation levels turn ratio phase stator winding system another phase system also modeled constant value phase system saturates iron core different weighting represented number turns relative reference stator system proposed model included field oriented control scheme simulations carried requested field winding currents demonstrate model dynamics results verified measurements test bench
planning resource management systems rural areas important consider criteria specific local social conditions criteria might change one region another hence best identified using participatory approach work propose participatory framework identify criteria derive weights identified criteria weights used parameters develop quantitative model evaluating efficiency system model serve support tool stakeholders simulate analyze scenarios evaluate alternatives select one best satisfies requirements use existing systems test model comparing efficiencies evaluated model efficiencies perceived stakeholders model calibrated repeating process statistically significant correlation achieved evaluated perceived efficiencies novelty proposed framework lies treating efficiencies perceived stakeholders ground truth since know systems well ultimate users framework successfully demonstrated using case study rainwater harvesting rwh systems indian village resulting calibrated model used plan new rwh systems region similar regions elsewhere framework used plan resource management systems various regions
high penetration solar energy result voltage rise midday growth residential air conditioning main contributor overloading voltage drop issues peak demand time paper provides hierarchical control scheme coordinate multiple groups aggregated thermostatically controlled loads regulate network loading voltage distribution network considering limited number messages exchanged realistic communication environment event triggered distributed control strategy proposed paper intermittent toggling air conditioners required active power adjustment shared among participating aggregators solve issue case study conducted simulation results presented demonstrate performance proposed control scheme
exposure high levels glucocorticoids gcs early life induces long lasting neuroinflammation gcs induce rapid degranulation mast cells release proinflammatory molecules promoting activation microglia astrocytes possible involvement oligodendrocytes however remains poorly understood studied whether high levels gestation activates inflammasome hippocampal oligodendrocytes mouse offspring oligodendrocytes control pups showed expression inflammasome components nlrp acs caspase levels increased prenatal administration dexamethasone dex synthetic cells also showed high levels tnf revealing activation inflammasome moreover showed increased levels receptor pannexin associated inflammasome activation however levels connexins either affected reduced nonetheless functional states pannexin connexin hemichannels elevated directly associated functional receptors observed dex treated brain slices hemichannel activity first increased hippocampal mast cells later microglia macroglia dex induced oligodendrocyte hemichannel activity mimicked urocortin corticotropin releasing hormone receptor crhr agonist response dex urocortin inhibited antalarmin crhr blocker mast cells microglia inhibitors increase hemichannel activity persisted several weeks birth cross fostering control mother reverse condition proposed activation oligodendrocyte inflammasome might relevant demyelinating diseases associated early life exposure high levels wiley periodicals inc
objectives prevalence inflammatory bowel diseases ibd use complementary alternative medicine cam common increasing definition cam therapy among practitioners patients variable aim study update understanding pediatric ibd patients use perceive define cam therapies methods surveyed families patients ibd followed gastroenterology division nationwide children hospital summer routine clinic visit survey included questions following demographic disease information use side effects associated prior conventional therapies attitudes toward use cam results questionnaire completed patients approached years women patients previously used average cam therapy used patients surveyed although patients families considered using cam common cam therapies included vitamins supplements stress management techniques dietary changes factors associated using specific cam therapies included self reported prior related side effects moderate severe disease activity families desired learn cam conclusions patients seen tertiary care center pediatric ibd frequently integrated cam therapies treatment regimen patients prior side effects severe disease likely use cam given high prevalence cam use pediatric gastrointestinal physicians knowledgeable open discussions cam therapies patients
purpose new teacher effectiveness measures potential influence principals hire teachers provide new richer information candidates traditionally information poor process article examines hiring process changing result teacher evaluation reforms research methods data come interviews central office personnel principals six urban school districts two charter management organizations sites systematically sampled based amount time resources devoted creating data systems implementing processes allow principals access teacher effectiveness data addition fieldwork also surveyed principals six eight systems total principals responded survey overall response rate findings findings suggest teacher effectiveness data used inform hiring decisions variation extent principals use measures hiring variation explained central office practices mediated principals approached teacher effectiveness data hiring process well individual principal characteristics principal knowledge skills perceived validity data social capital implications research practice results demonstrate ways school systems principals incorporating teacher effectiveness data hiring process principal preparation programs school systems focus ensuring principals skills resources use data human capital decisions
paper presents simple efficient reliable broadcast algorithm asynchronous message passing systems made processes among may behave arbitrarily byzantine processes algorithm requires two communication steps messages compared bracha algorithm resilience optimal requires three communication steps messages proposed algorithm shows interesting tradeoff communication efficiency resilience
context kinesio taping taping technique extensively used rehabilitation sports injuries however effect delayed onset muscle soreness entirely clear objectives investigate effect kinesio tape quadriceps femoris muscle pain flexibility sprint performance squat exercise design crossover study setting university research laboratory participants female university students age weight height main outcome measures pressure pain threshold quadriceps femoris recorded using pressure algometry quadriceps femoris flexibility measured range motion knee flexion stainless steel goniometer sprint speed measurements conducted using photocells placed participants completed conditions application application washout period measurements taken baseline postexercise condition applied immediately exercise protocol remained skin results squat exercise reduced flexibility increased pain sprint time compared baseline application resulted similar sprint time muscle pain condition maintained flexibility compared baseline conclusions application immediately squat exercise effect muscle pain short sprint performance maintains muscle flexibility days recovery
although tendency towards semantic web increasing current web keen semantic data several web application domains need present data form graphs get information knowledge allow semantic web searching deal domains example geographic data data area bioinformatics social networks even corporate search engines domains already store data relational database management systems capable queried directly semantic web applications paper propose semi automated method map data relational databases rdf structures true single source database well different source databases results show complexity order number records processed comes performance creating output mapping relational database rdf files
introduction perfluorinated alkylated substances pfas persistent industrial chemicals resulted global environmental exposures previous epidemiological studies reported possible effects immune system developmental pfas exposure possible impact childhood infectious disease unclear objectives investigate association prenatal exposure pfas symptoms infections age years methods odense child cohort going prospective study children health serum concentrations perfluorooctane sulfonic acid pfos perfluorooctanoic acid pfoa perfluorohexane sulfonic acid pfhxs perfluorodecanoic acid pfda perfluorononanoic acid pfna measured pregnant women gestational week women reported symptoms infection child every two weeks one year period association prenatal exposure pfas symptoms estimated using logistic regression model negative binomial regression model latter outcome reported incidence rate ratio irr models adjusted maternal age educational level parity child age results average children experienced symptoms infection time one year pfos exposure high tertile compared low tertile associated statistically significant increased proportion days fever irr trend increased odds experiencing days fever median latter tendency also apparent pfoa higher concentrations pfos pfoa tended increase number episodes occurrence fever coughing fever nasal discharge one year study period conclusion found positive association prenatal exposure pfos pfoa prevalence fever may sensitive marker infection finding agreement immunotoxic effect prenatal exposure pfas wider implications childhood infectious disease deserve attention elsevier ltd rights reserved
objectives patients qualified cardiac resynchronization therapy crt documented atrial fibrillation prior crt implantation finding associated worse prognosis studies evaluated importance post implant device detected study aimed assess prognostic impact device detected atrial high rate episodes ahre surrogate design data retrospectively obtained consecutive patients receiving crt baseline clinical data data crt device interrogations performed median months crt implantation evaluated regard prediction composite endpoint death heart transplant appropriate shock therapy median follow time months post implant results study included patients preoperative present associated worse outcome cumulative burden ahre months post implant independent predictor primary endpoint first months crt implantation ahre detected patients preoperative diagnosis finding associated worse outcome conclusions crt recipients cumulative burden ahre first year follow associated worse long term clinical outcome prospective trials needed determine rhythm control strategy preferred patients crt
prenatal development mandible important factor postnatal function examine quantitatively normal abnormal developmental changes mandible evaluated morphological changes mineralizing mandibles thin plate spline tps including bending energy procrustes distance procrustes analyses including warp analysis regression analysis discriminant function analysis calculated lateral views mandibles mice human fetuses using scanned micro computed tomography images alizarin red stained specimens respectively compared different developmental stages detect abnormalities data sets evaluate deviation normal development mouse fetuses embryonic day normal deformed mandibles latter caused suturing jaw normal knockout mutant mice receptor tyrosine kinase like orphan receptor ror mice large prenatal period small postnatal day suggesting mandibular shape changes rapidly prenatal early postnatal periods humans mandibles peaked weeks gestation suggesting time dependent change mandibular shape tps procrustes analyses statistically separated abnormal mandibles sutured ror mutant mouse fetuses normal mandible results suggest tps procrustes analyses useful assessing morphogenesis deformity mandible anat rec wiley periodicals inc
posaconazole may useful salvage treatment invasive fungal infections ifis aim study evaluate efficacy posaconazole either posaconazole oral suspension sus delayed released tablet tab patients ifi retrospective review patients received posaconazole ifi university utah health sciences center december march conducted total episodes posaconazole proven episodes probable episodes ifi identified patients median age years majority patients underlying haematological diseases posaconazole sus tab used episodes episodes respectively duration posaconazole ranged days median days posaconazole tab achieved favourable serum posaconazole trough concentrations median compared posaconazole sus median overall clinical success rate posaconazole episodes one patient died progression ifi adverse events noted two patients posaconazole sus tab may used effectively ifi
despite recent increase greening existing buildings literature continues focus investigating barriers greening new buildings goal research develop method using failure mode effects analysis investigate barriers greening existing buildings using leadership energy environmental design version building operations maintenance existing buildings rating system specific objectives included using method investigate potential failure modes certifying existing buildings using rating system well causes effects rank failure modes effects causes order priority identify opportunities lessons learned implementing method research involved bringing together focus group five local experts familiar rating system one day workshop experts along research team tasked identifying potential failure modes along causes effects detection controls rating probability occurrence failure modes severity failure effects ease detection failure controls analysis workshop data showed half identified failure causes technical nature financial causes organizational causes representing failure causes respectively analysis also showed intricate relationship technical financial organizational social environmental factors therefore different factors need integrated interlinked rather compartmentalized separated research provided new comprehensive method based use failure mode effects analysis evaluate risks greening existing buildings using leadership energy environmental design rating system workshop participants found failure mode effects analysis excellent method identifying evaluating ranking green building certification risks helped foster interdisciplinary collaboration participants various disciplines well researchers industry stakeholders nevertheless need future applications method limit scope analysis specific categories credits rating system narrow scope would facilitate analysis workshop data enable depth comprehensive analysis risks risk types including ones traditionally tend ignored organizational social risks elsevier ltd rights reserved
introductionthe antihistaminic antazoline ant reported highly effective safe rapid conversion atrial fibrillation therefore analyzed underlying mechanisms experimental whole heart model methods resultsisolated retrogradely perfused rabbit hearts underwent standardized protocol employing atrial burst pacing induced five hearts baseline conditions seven episodes thereafter combination acetylcholine isoproterenol employed enhance occurrence two monophasic action potential recordings left two right atrial epicardium showed decrease atrial action potential duration aapd msec atrial effective refractory period aerp msec infusion acetylcholine mol isoproterenol mol led induction hearts episodes simultaneous infusion ant mol led complete suppression inducible hearts treatment ant also led significant increase aapd msec aerp msec leading marked increase atrial postrepolarization refractoriness aprr msec results compared rabbits treated flecainide flecainide induced significant increase aprr resulted induction seven hearts episodes hearts inducible acetylcholine isoproterenol episodes conclusionadministration ant highly effective suppressing antiarrhythmic effect could explained significant increase postrepolarization refractoriness result marked increase aerp compared aapd
individual differences early attention associated later social cognitive emotional development attentional deficits first year associated risk developmental disorders autism spectrum disorder asd first year inventory fyi baranek watson crais reznick developed identify month olds risk asd diagnosis current study identifies fyi items reflect aspects early attention might predict future typical atypical social cognitive emotional development using series theoretical statistical methods developed attention based constructs fyi responding social attention rsa initiating social attention isa nonsocial sensory attention nsa database completed fyis analyzed using constructs determine strength relations among items cronbach alpha analyses indicated good internal consistency item distribution supported using confirmatory factor analysis data analyses showed statistically significant relations scores domains months subsequent social responsiveness scores years analyses demonstrating statistical predictive validity fyi attention constructs support use innovative explorations infant behavioral patterns used predict typical atypical individual trajectories development later social cognitive emotional skills
nanomagnet logic nml among emerging technologies might replace cmos next decades according physical characteristics better exploit potential technology similar ones use parallel architectures regular layout avoid long interconnection signals advised systolic arrays sas among architectures composed grid equal processing elements locally interconnected however usually implemented execute small set algorithms reason throughout years appealing solution cmos seriously analyze potentials nml complex architectures must conceived physical implementation explored considering realistic technological constraints increasing complexity nml circuits two issues noticed need regular structure arises time helps reduce intrinsic pipelining nature nml configured used several applications without developing dedicated design algorithm capability synthesize place route nml circuits fundamental demonstrate feasibility architecture two important conditions efficiently managing complexity design sticking characteristics technologically feasible time writing paper address issues presenting new reconfigurable programmed execute different algorithms provide two examples show working principle moreover array synthesized simulated aid first real tool nanotechnology circuits conceived torino politecnico nanotechnology tool joint contribution architectural physical design levels gives relevant step forward state art demonstration emerging technology potential
well known emotions intersect obvious social categories race influencing targets categorized emotions read faces examined influence emotional expression perception less obvious group memberships absence obvious stable physical markers emotion may serve major avenue group categorization identification specifically examined whether emotions embedded mental representations sexual orientation political affiliation whether people may use emotional expressions communicate group memberships others using reverse correlation methods found mental representations gay liberal faces characterized positive facial expressions mental representations straight conservative faces study furthermore participants evaluated expressing positive emotions enacting self defined gay liberal versus straight conservative facial expressions lab study addition neutral faces morphed happiness perceived gay morphed anger compared unmorphed controls study finally found affect facilitated perceptions sexual orientation political affiliation naturalistic settings study together studies suggest emotion defining characteristic person construal people tend use signaling group memberships receiving signals categorize others
objective purpose present study investigate correlation serum testosterone levels bone mineral density bmd postmenopausal women materials methods study group made postmenopausal women admitted tertiary center serum calcium phosphorus albumin parathyroid hormone pth thyrotropin tsh vitamin total testosterone concentrations measured subjects categorized three groups regarding bone mineral density bmd values normal osteopenia osteoporosis subjects also categorized three groups according serum testosterone levels low testosterone normal testosterone high testosterone results significant difference found serum testosterone tsh calcium phosphorus albumin pth hydroxyvitamin levels among patients normal bmd osteopenia osteoporosis lumbar spine total femur femoral neck trochanteric intertrochanteric ward triangle bmd values similar different testosterone levels conclusion correlation serum testosterone levels patient age body mass index measured bmd values given findings study failed demonstrate statistically significant relationship testosterone bmd adjustment risk factors osteoporosis might distinctive effect setting
background psychosocial phenotype interstitial cystitis bladder pain syndrome bps urogenital condition without known organic causes proposed psychosocial variables including interpersonal maltreatment negative affect studied association bps specificities relationships childhood trauma close others psychiatric dysfunctions negative affect post traumatic psychopathology urogenital symptoms established methods bps patients recruited together patients acute cystitis served clinical controls standardized scales used assess various potentially traumatizing events childhood adulthood well psychiatric dissociation negative affect urogenital symptoms results among potentially traumatizing events perpetrated close others childhood found salient features discriminating bps group control group divided subgroups according history childhood trauma close others bps patients childhood trauma close others dissociative anxiety symptoms compared control group two subgroups differ urogenital symptom severity conclusions childhood trauma close others rather types interpersonal trauma differentiating characteristic bps patients childhood trauma related psychosocial phenotype distinct clinical profile dissociation anxiety proneness identified future studies investigate whether distinct set pathogenic factors exists bps patients history childhood trauma close others even subgroup readily differentiated urogenital symptoms elsevier inc rights reserved
soil water evaporation cropping surface wasteful loss potentially productive rainwater thus efficient use rainwater help sustain dryland production purpose study quantify effect canopy shading mulch levels soil water evaporation section field rainwater harvesting irwh evaluate ritchie alpha stroosnijder beta soil evaporation models effect surface treatments microlysimetric method used measure beneath maize zea mays canopy three consecutive drying cycles across basin runoff sections irwh fine sandy loam soil bainsvlei kenilworth ecotope first main effects four runoff strip lengths rsl three treatments statistically analysed weighted values second treatments allocated main plots four levels allocated according lengths runoff sections third cumulative sigma measurements used evaluate empirical equations related time alpha potential evaporation beta two models compared considering effects surface treatments significantly higher observed bare treatment compared either two mulched treatments viz mulch level cover significant differences found mulched treatments insignificant effect rsl treatments implied dynamics spatial distribution soil water energy influenced evaporation result green mulch shading cover beneath canopy less suppressive properties developed bare surface efficient restriction found high mulch shading cover treatments alpha beta values ranged respectively treatments simulated sigma underestimated ritchie model overestimated stroosnijder model main effect shading due dominant effect energy limited evaporation stage mulched treatments mainly driven soil limited stage stage evaporation ritchie model performed well estimate sigma basin area potential stroosnijder model unshaded runoff strips microclimate cropping system changed according surface treatments highly influenced losses irwh dryland production elsevier rights reserved
background aim aim study assess efficacy safety sofosbuvir based interferon free therapies liver transplantation recipients hepatitis virus infection recurrence methods systematic literature search conducted pubmed embase web science central cochrane library without time language limitation search strategy used sofosbuvir transplantation sustained virologic response weeks end treatment svr rate incidence serious adverse events saes adverse events discontinuation rate confidence intervals pooled random effects model results twenty two studies patients included meta analysis pooled svr rate svr rate higher patients mild fibrosis patients advanced fibrosis cirrhosis patients hepatitis virus genotype pooled svr rate pooled saes incidence pooled discontinuation rate adverse events saes conclusions sofosbuvir based interferon free therapy effective well tolerated treatment strategy patients hepatitis virus infection recurrence liver transplantation
paper authors propose multi modification design model new type visual expression visual expression computer unified called computer graphics today circumstances visual expression computer indicates main role generate image virtual space computer image difficult drawn recreated physically recent years expressive abilities enhanced words complicated images drawings require much calculation became possible easy due speeding computer processing however alone broaden variety expressivity visual expression computer need extend ability usually history visual expression referred history much progress innovation terms creativity since socalled determined author describes multi modification design model new visual expression computer demonstrated actual produced work
mesolimbic dopamine circuitry determines behaviors positively reinforcing therefore encoded memory become part behavioral repertoire natural reinforcers like food sex activate pathway thereby increasing likelihood consummatory social sexual behaviors oxytocin implicated mediating natural reward synthesizing neurons project ventral tegmental area vta nucleus accumbens nac however direct neuroanatomical evidence regulation neurons within vta sparse phenotype receptor otr expressing neurons originating within vta delivered cre inducible adeno associated virus drives expression fluorescent marker vta male mice cre recombinase driven otr gene expression otr expressing vta neurons project nac prefrontal cortex extended amygdala forebrain regions less otr expressing neurons identified neurons defined tyrosine hydroxylase colocalization instead almost otr expressing cells vta glutamate glu neurons indicated expression mrna vesicular glu transporter vglut one third otr expressing vta neurons colocalize either glu phenotypic markers thus otr expression vta neurons implicates regulation reward circuitry complex direct action neurotransmission comp neurol wiley periodicals inc
aimstudies provided insights factors may facilitate inhibit parent infant closeness neonatal units none specifically focused perspectives senior neonatal staff aim study explore perceptions experiences consultant neonatologists senior nurses five european countries regard issues methodssix small group discussions three one one interviews conducted consultant neonatologists senior nurses representing nine neonatal units estonia finland norway spain sweden interviews explored facilitators barriers parent infant closeness implications policy practice thematic analysis undertaken resultsparticipants highlighted humanising care agenda enabled parent infant closeness aspiration pointed neonatal units different stages achieving facilitators barriers physical closeness included socio economic factors cultural norms designs neonatal units resource issues leadership staff attitudes practices relationships staff parents conclusionvarious factors affected parent infant closeness neonatal units european countries needs political motivation appropriate policy planning legislation resource allocation increase measures support closeness agendas neonatal units
smart grid modernization electrical power system recognized globally vision achieve self automated electrical network flexible accessible reliable economical integration distributed renewable generation transmission network power system restoration faces new challenges demand power increases ability perform restoration blackouts vital smart grid aims perform automated action restoring power back transmission network feature system also known self healing self healing aims perform self adjustments normal operation state performs self restoration power system identifying reacting interruption minimal human intervention objective self healing supply electricity users disturbances making system highly dependable efficient paper presents approach perform power restoration mesh transmission network approach knowledge based environment first created performing case studies mesh network set rules developed environment search technique used responding contingency observed obtaining restoration solution
paper introduces nonlinear control scheme based differential flatness approach controlling speed torque permanent magnet synchronous motor pmsm drive differential flatness estimation model based approach two state observers proposed estimate load torque disturbance stator resistance represent losses inverter pmsm means voltage drop help improve pmsm drive system efficiency using flatness property propose simple solutions dynamics stabilization problems design controller parameters autonomous operating point moreover high dynamics disturbance rejection achieved validate proposed method hardware system realized laboratory digital estimation accomplished dspace controller dsll platform simulation experimental results small scale pmsm rpm laboratory corroborate excellent control scheme motor drive cycles
report case cryptococcal sinusitis rare presentation cryptococcus neoformans infection patient multiple myeloma objective case report highlight utility structural functional imaging modalities differential diagnosis sinonasal soft tissue masses immunocompromised patient population pet first imaging modality patient presented routine follow staging multiple myeloma asymptomatic time presentation pet findings prompted evaluation mri aid differential diagnosis respect neoplastic versus infectious etiology ultimately surgical excision histopathology required provide definitive diagnosis final histopathology displayed yeast organism staining consistent cryptococcus neoformans gatti patient subsequently underwent treatment infection along continued treatment multiple myeloma knowledge first known case cryptococcal sinusitis patient neoplastic disease imaging represents important tool differentiate fungal infection neoplasm immunocompromised patient population population immunocompromised patients continues grow relevance diagnosis well use alternative imaging modalities becoming important clinical practice elsevier inc rights reserved
experimental study two kinds electrical circuits domino ladder nested ladder presented domino ladder known already appeared theory fractional order systems nested ladder circuit presented article first time fitting measured data new approach suggested based using mittag leffler function means data fitted solution initial value problem two term fractional differential equation experiment showed frequency domain domino ladder behaves system order nested ladder system order perfect agreement theory developed design time domain however order domino ladder changing roughly almost order nested ladder changing similar manner roughly almost cases order never reached systems remain systems non integer order less studied types electrical circuits provide first known examples circuits made passive elements exhibit time domain behavior variable order
crisis management process includes catching evaluating crisis signals needs take implement necessary precautions order overcome crisis minimal damage detecting early warning signals crisis contributes firms hinder occurrence crisis survive without huge financial losses factors contribute construction firms survive zero defect listed follows catching indirect signals crisis developing proactive methods defend crisis means signals iii taking crisis control taking required measures crisis recovery firm lastly recording lessons learned crisis construction firms successfully manage crisis quit minimum loss expand market shares crisis words firms escape crisis zero minimum damage may strategically competitive advantages existing rivals considering issues study describes concept crisis management terms construction industry introduces related objectives characteristics addition innovative crisis management approaches corresponding process discussed detail perspective construction companies fact virgin area construction management literature thus contribute creative innovative management companies potential crises micro macro levels consequently study attempts reveal construction firms manage crises better turn former positions short term innovation based means authors published elsevier ltd
steam injector known passive jet pump heat exchanging device operates without external power source mechanical machineries utilizes direct contact condensation heat transfer steam water jet driving mechanism operation capable discharging sub cooled water higher pressure inlet fluids pressure addition excellent heat transfer capability times shell tube heat exchanger present study thermal hydraulics characteristics water jet centered supersonic system investigated experimental analytical approaches body manufactured stainless steel equipped overflow port water injection nozzle designed shaft driving mechanism freely adjust axial location water nozzle steam inlet cross sectional area high pressure steam supplied boiler capable supplying saturated steam maximum pressure mpa current test facility water jet injected mass flow rate pressure temperature measurements conducted inlet outlet steam injector system well overflow port investigate operation characteristics results showed water jet centered promising functionality passive coolant injection view quick start operable condition limits discharge pressure heat transfer capabilities current inlet conditions addition obtained experimental results compared analytical model assess predictive capability discharge pressure value reasonable agreement obtained elsevier ltd rights reserved
objectives emergency contraceptive pills ecps underused preventing unintended pregnancy women willing use even risk conceiving paper examines whether increased knowledge ecps may increase intention use products methods factors associated intention use emergency contraception assessed among women participated nationally representative sexual health netherlands survey logistic regression models included demographics prior use ecps ecp knowledge results seventeen percent women intend use unprotected sexual intercourse unsure whether would use intention strongly related prior use children two six knowledge items related intention multivariate analyses aware ecps obtained without prescription upgrades intention whereas knowing woman still get pregnant taken ecp negative impact intention conclusions improving knowledge may contribute intention use role modest understand reasons behind ecp use essential study contribution factors like attitudes social norms
assessment attack surface formidable challenge present day dynamic networks essentially attack surface computer network subset network configuration vulnerabilities adversary use compromise target network incremental fashion large number metrics available network security risk assessment however fail measure temporal variation network attack surface overcome problem propose graph distance metrics based maximum common subgraph mcs graph edit distance ged particular make use classical graph distance metrics quantify distance pair successive attack graphs generated dynamic network since attack graph capable successfully capturing attack surface underlying network distance pair consecutive attack graphs generated observed sampling interval indicates change network attack surface validate efficacy usability graph distance metrics proposed study tested different metrics set different network models viz flat external internal dmz experimental results show mcs ged based graph distance metrics successfully capture temporal variation attack surface also generate alert security events responsible change using graph distance metrics pinpoint events cause significant change network attack surface locate dangerous hosts network effect increasing vulnerabilities hosts advantage using metrics scale polynomially graphs size independent graphs topology also evident test results performance mcs ged based metrics almost similar hence computation one metric enough detect temporal variation network attack surface mcs ged based graph distance metrics oblivious semantic initial conditions attack graphs thus scope improving performance sensitivity considering semantic elsevier ltd rights reserved
objective insufficient poor quality sleep prevalent children significant public health concern due negative consequences health certain sleep related behaviours associated improved sleep sleep behaviours amenable efforts targeted towards behaviour change parental educational interventions successful improving parents knowledge children health outcomes areas health population based educational interventions designed improve parents knowledge healthy children sleep study aimed design test educational tool increase caregivers knowledge healthy children sleep primary care setting setting hospital based pediatric primary care clinic children attend well child sick visits method parents children aged three months years completed two surveys one prior one receiving intervention surveys assessed children sleep habits pre intervention parental sleep beliefs sleep knowledge pre post intervention intervention short informational brochure results following intervention significant increase parents knowledge regarding children healthy sleep number parents planned make positive behaviour changes regarding child sleep practices conclusion simple written educational interventions may effective tools increase parents knowledge promote healthy sleep behaviours children
investigation paper fifth order nonlinear schrodinger equation describes propagation attosecond pulses optical fiber based lax pair infinitely many conservation laws derived aid auxiliary functions bilinear forms one two three soliton solutions analytic forms generated via hirota method symbolic computation soliton velocity varies linearly coefficients high order terms head interaction bidirectional two solitons overtaking interaction unidirectional two solitons well bound state depicted interactions among three solitons two head one overtaking interactions three overtaking interactions interaction bound state single soliton bound state displayed graphical analysis shows interactions two solitons elastic interactions among three solitons pairwise elastic stability analysis yields modulation instability condition soliton solutions elsevier inc rights reserved
transient computing systems energy storage operate directly energy harvesting systems often faced inherent challenge low current transient power supply paper propose power neutral operation new paradigm systems whereby instantaneous power consumption system must match instantaneous harvested power power neutrality achieved using control algorithm dynamic frequency scaling modulating system performance gracefully response incoming power detailed system model used determine design parameters selecting system voltage thresholds operating frequency raised lowered system hibernated proposed control algorithm power neutral operation experimentally validated using microcontroller incorporating voltage threshold based interrupts frequency scaling microcontroller powered directly real energy harvesters results demonstrate power neutral system sustains operation longer speedup application execution
purpose purpose article investigate possible differences effect three types masks acute treatment cluster headache patients methods fifty seven patients according ichd criteria participated single blinded semirandomized placebo controlled crossover inpatient study attacks treated oxygen delivered demand valve oxygen dvo optimask simple mask liters min placebo delivered dvo minutes primary endpoint two point decrease pain five point rating scale within minutes results patients multiple attacks reached point placebo significant differences masks primary endpoints minutes two point decrease using dvo compared placebo minutes pain free pain relief using dvo placebo dvo preferred compared simple mask ptimask first attack dvo significantly better achieving pain relief minutes treatment dvo ptimask reduced need rescue medication compared simple mask respectively treatment related adverse events observed conclusion primary endpoint pain relief minutes non significant however post hoc analysis first attack significantly favored dvo therapy ptimask dvo resulted decreased need rescue medication recommend patients offered dvo ptimask oxygen therapy abandoned
inverse problem wave equation outside obstacle dissipative boundary condition considered observed data given single solution wave equation generated initial data supported open ball explicit analytical formula computation coefficient point surface obstacle nearest center support initial data given copyright johnwiley sons ltd
well known distance estimation immersive virtual reality environments suffers compression viewed egocentric perspective head mounted display previous research indicates providing user virtual avatar high geometric motion fidelity may alleviate problem little work done investigate properties avatar representation influence distance estimation poster report results evaluation user distance perception different avatar representations results indicate anthropometric fidelity avatar stronger effect distance perception visual fidelity
common criticism diagnostic statistical manual mental disorders american psychiatric association criteria based behavioral descriptions underlying biological mechanisms increasingly calls intensified biologically based approach conceptualizing studying treating psychological disorders exemplified research domain criteria project rdoc among well studied neurobiological mechanisms reward processing moreover individual differences reward sensitivity related risk substance abuse depression current review synthesizes available preclinical electrophysiological neuroimaging literature reward processing transdiagnostic multidimensional perspective findings organized respect key reward constructs within positive valence systems domain rdoc matrix including initial responsiveness reward physiological liking approach motivation physiological wanting reward learning habit formation current review describe neural basis reward elucidate differences reward activity substance abuse depression suggest framework integrating disparate literatures discuss utility shifting focus diagnosis process understanding liability morbidity ultimately believe integrative focus abnormal reward functioning across full continuum clinically heterogeneous samples rather within circumscribed diagnostic categories might actually help refine phenotypes improve prediction onset recovery disorders elsevier rights reserved
binary formamidine complexes formulated formamidine ligands synthesized characterized using different tools elemental analyses mass infrared spectroscopy magnetic susceptibility thermal analysis dft calculations complexes diamagnetic electronic spectral data showed peaks due square planar complexes optimized structures complexes indicate distorted square planar geometry bond angles range electronic energies highest occupied molecular orbital lowest unoccupied molecular orbital energies complexes negative values indicated stability complexes complexes polarized indicated dipole moment values debye complexes neutral stable non hygroscopic complexes noticeable cytotoxicity mcf hep hepg elsevier rights reserved
objectives aims study assess changes uninsured rates among trauma patients age versus years whether associated changes post discharge rehabilitation determine whether changes driven rehabilitation provided home skilled nursing facilities snfs acute inpatient facilities determine whether changes vary among stratified subgroups trauma related best practice factors summary background data rehabilitation important component high quality trauma systems access heavily influenced insurance status wake policy changes affecting insurance coverage remains unknown extent insurance changes associate variations rehabilitation access use among otherwise similar patients methods regression discontinuity models used assess changes insurance status rehabilitation age versus years among adults ages years years age related medicare eligibility data extracted national trauma data bank results total patients included discharged rehabilitation medicare eligibility associated abrupt confidence interval percentage point decline uninsured confidence interval percentage point increase rehabilitation age versus years enabling additional patients access rehabilitation differences driven snf use greatest among patients less severe clinical presentations restriction based medicare payment eligibility patients length stay days snf requirement presumptive diagnosis codes inpatient facilities rule demonstrated abrupt gains snf inpatient care conclusions results reveal magnitude changes access rehabilitation associated changes insurance coverage age years use quasiexperimental models enabled meaningful consideration health policy change
extraction molten iron slag liquid phase lower part blast furnace hearth usually accomplished according operational experience involves high degree uncertainty mainly liquid level directly measured study presents methodology obtaining multistep models forecast hearth liquid level measuring voltage generated blast furnace shell strongly correlated hearth liquid level results show electrical signal nonstationary nonlinear time series appropriate treatment represented time delay neural network tdnn model comparisons made linear time series models represented autoregressive moving average model seasonal autoregressive integrated moving average model results indicate tdnn model provides better forecasting performance one hour ahead note practitioners work motivated need better knowledge regarding liquid level blast furnace hearth information affects strategy opening closing tapholes blast furnace consequently production control operational quality due difficulties measuring liquid level hearth directly system installed uses voltage generated hearth shell liquid level sensor hearth study analysis treatment signal performed achieving stationary nonlinear signal strongly correlated level molten iron slag inside blast furnace hearth mathematical model represents signal developed implemented online blast furnace digital control system enable forecasting liquid level one hour ahead computational tool aids operators engineers deciding advance instants open close tapholes thereby increasing safety financial gains
wheel direct drive motors placed inside drive wheels electric vehicles deliver large torque without mechanical gear often machines synchronous type permanent magnets large pole pair number consequence high peak torque cogging torque torque ripple increased measures taken decrease vibrations due cogging torque torque ripple result noise reduced motor durability paper analytical equations finite element method derived developed used order analyse dependence cogging torque magnet shape size novel magnet shape found eliminates cogging torque without reducing motor torque constant increasing magnet size shape applicable surface mounted permanent magnet motor high number pole pairs
glucocorticoid induced osteoporosis gio one common causes secondary osteoporosis given glucocorticoids considered main component treatment protocols variety inflammation immune mediated diseases besides use adjuvant several chemotherapeutic agents crucial find ways overcome critical adverse effect caffeic acid phenethyl ester cape natural compound derived honeybee propolis displayed promising antiosteoporotic effects mechanical bone injury various studies current work aimed investigating potential protective effect cape gio vivo emphasis modulation oxidative status receptor activator ligand rankl osteoprotegrin opg signaling results showed cape opposed dexamethasone dex mediated alterations bone histology tartarate resistant acid phosphatase trap activity addition cape restored oxidative balance runt related transcription factor runx expression reduced caspase activity femur tissues administration cape dex normalized rankl opg ratio akt activation indicating reduction dex osteoclastogenesis conclusion concurrent treatment cape dex exhibited promising effects protection dex induced osteoporosis opposing osteoclastogenesis protecting osteoblasts potent antioxidant activity cape least part involved anti apoptotic effects modulation runx rankl opg signals use cape enriched propolis formulas strongly recommended patients chronic glucocorticoid therapy help attenuation gio elsevier inc rights reserved
new technique measure capacitor capacitive sensor means direct sensor microcontroller interface circuit need calibration capacitor proposed basically measurement process consists three consecutive steps charge discharge charge capacitor test non linear equation obtained solved dependent known circuit parameters experimental results show possible measure wide range capacitor values maximum deviation reference value temperature changes degrees yield relative errors lowest measured capacitor range uncertainty holds enables measurement commercially available capacitive sensors main advantage proposed technique cost space reduction final design
comparability grain sizes emerging different methods discussed including image based grain size analysis waterworked gravel bed surfaces laboratory field experiments analyzed detail grain sizes estimated using freely available object detection software compared grains measured calipers hand basis laboratory field data pebble dimensions determined square hole sieving demonstrated underestimate real pebble dimensions factor pebble dimensions derived images underestimate pebble count measurements similar amount thus present extensive data set software detected grain sizes directly compared grain sizes gained square hole sieving order magnitude results support future wide spread use image based sieving grain size distribution analyses hydraulic research engineering american society civil engineers
despite international efforts stigma still significant issue people living hiv aids plwha paper explores stigma encountered health interactions focusing strategies plwha use manage reduce hoped findings improve future interactions contributing towards understanding practitioner patient relationship data drawn small qualitative study conducted christchurch new zealand fourteen participants took part semi structured face face interviews participants interviewed codes themes developed inductive thematic analysis interview transcripts findings identified whilst majority participants positive experiences nearly faced stigma health interactions encounters due healthcare workers holding exaggerated fears transmission maintaining confidentiality privacy main way participants managed stigma seeking control interactions overarching strategy could divided three key themes selective disclosure hiv status self advocacy developing hiv knowledge discuss findings context current literature comparing results strategies previously identified social settings
tcud method kim lee minimize undesirable lateral displacements cable bridge structures including unstrained lengths cable members unknowns introducing additional constraint conditions axial deformations girder main tower deviating target configuration however unavoidable self anchored cable bridges considered hand ifm initial force method used adjust axial deformations conform initial shape critical unstrained lengths cables accurately evaluated study improved schemes tcud method ifm finding initial shape dimensional cable supported bridges dead load presented purpose tcud method initial force method firstly reviewed two improved algorithms overcome shortcomings previous initial shaping analysis methods developed based elastic catenary cable element nonlinear space frame element finally accuracy effectiveness proposed analysis algorithms demonstrated numerical application dimensional initial shape problems self anchored suspension cable stayed bridges
inverse problem identifying unknown spacewise dependent source wave equation element neumann type measured output investigated studies attempted reconstruct unknown spacewise dependent source final observation since boundary measured data feasible engineering viewpoint identification problem wide applications particular electrical networks governed harmonically varying source linear wave equation cos omega omega frequency unknown source term paper fourier collocation algorithm reconstructing spacewise dependent source developed algorithm based fourier expansion direct problem solution applied minimization problem tikhonov functional taking partial sum fourier expansion tikhonov regularization applied obtained discrete ill posed problem obtain high quality reconstruction large values noise level numerical filtering algorithm used smoothing noisy data application demonstrate ability algorithm benchmark problems particular source identification problem electrical networks governed mono frequency source numerical results show proposed algorithm allows reconstruct spacewise dependent source enough high accuracy presence high noise levels imacs published elsevier rights reserved
background individual studies demonstrated potential diffusion weighted magnetic resonance imaging dwi mri identifying inflamed bowel segments however studies conducted rather small patient cohorts cases means enterography purpose demonstrate feasibility detecting inflamed bowel segments large collective patients crohn disease using dwi enteroclysis enterography compare results techniques also considering clinical parameters means harvey bradshaw index hbi material methods ninety six patients underwent mri enteroclysis patients enterography additional dwi hbi well apparent diffusion coefficients adc areas inflamed normal bowel wall determined thus resulting bowel segments visualized subsequently statistically analyzed results significant differences adc values enteroclysis enterography inflammation normal wall areas inflammation showed statistically highly significant lower adc values areas normal bowel wall adc threshold distinguish normal inflamed bowel segments sensitivity specificity highly significant correlation could shown adc hbi values conclusion dwi mri facilitates recognition inflamed bowel segments patients crohn disease adc values show excellent correlation hbi significant differences adc values enteroclysis enterography adc threshold differentiates normal inflamed bowel wall
nearly million new sexually transmitted infections occur every year united states traditionally men demonstrated much greater risk contraction mortality stds perhaps tend engage number risky sexual activities research masculinity suggests gender roles influence males sexual health encouraging risk taking behavior discouraging access health services narrowly defining roles partners however despite propensity highly masculine men engage high risk sexual behavior reason suspect men end continuum may still driven engage similar high risk behaviors consequence gender socialization discrepancy stress form gender role stress occurs men fail live ideal manhood derived societal prescriptions gender role discrepancy present study surveyed national sample men via amazon mechanical turk assess perceived gender role discrepancy experience discrepancy stress associations risky sexual behavior potential contraction stds results indicated men believe less masculine typical man gender role discrepancy experience distress stemming discrepancy discrepancy stress engage high risk sexual behavior subsequently diagnosed stds findings discussed relation implications primary prevention strategies
background bipolar disorder common chronic illness characterized high levels morbidity cause mortality lithium one gold standard mood stabilizer treatments identification good partial non responders clinical settings inconsistent methods used established rating scale alda scale classify degree lithium response good response partial response non response large multicentre clinically representative sample well characterized cases bipolar disorders next examined previously reported clinical predictors response determine factors significantly differentiated three response groups results cases received lithium least months treatment bipolar disorder cases classified good response partial response non response lifetime history mixed episodes alcohol use disorders occurred partial response non response groups good response cases family history bipolar disorder borderline statistical significance frequent good response group compared non response group trend bipolar disorder associated non response conclusions three factors previously identified predictors lithium response significantly differentiated response groups identified sample interestingly factors found occur often expected chance hypothesized may represent shared underlying factor dimension prospective studies predictors performance alda scale recommended
work examines operation residential building integrated micro trigeneration system whole year means dynamic simulation software investigated system based natural gas fuelled internal combustion engine based cogeneration unit heating purposes winter domestic hot water production whole year auxiliary thermal energy supplied natural gas fired boiler cogeneration device coupled combined storage tank fed electric air cooled water chiller cooling purposes summer plant served multi family house composed three floors located south italy compliant thermal transmittances suggested italian law primary energy consumption equivalent carbon dioxide emissions operating costs proposed system evaluated based simulation results according italian scenario compared associated conventional system composed natural gas fired boiler coupled air cooled water electric chiller fed electric grid performed analyses allowed assess energy environmental economic suitability proposed scheme potential benefits comparison reference plant based separate energy production
short term exposure ambient air pollution linked adverse cardiovascular effects previous research focused primarily particulate matter induced responses gaseous air pollutants also contribute cause short term cardiovascular effects mechanisms underlying effects adequately described however immediate nature response suggests involvement irritant neural activation downstream autonomic dysfunction thus study examines role trpa irritant sensory receptor found airways cardiac response mice acrolein ozone conscious unrestrained wild type cbl trpa knockout mice implanted radiotelemeters exposed ppm acrolein ppm ozone filtered air heart rate electrocardiogram ecg recorded continuously exposure analysis ecg morphology incidence arrhythmia heart rate variability hrv performed cardiac mechanical function assessed using langendorff perfusion preparation post exposure acrolein exposure increased hrv independent well incidence arrhythmia acrolein also increased left ventricular developed pressure mice post exposure ozone produce changes cardiac function neither gas produced ecg effects changes hrv arrhythmogenesis mechanical function mice data demonstrate single exposure acrolein causes cardiac dysfunction trpa activation autonomic imbalance characterized shift toward parasympathetic modulation furthermore clear lack ozone effects although gaseous irritants capable eliciting immediate cardiac changes gas concentration properties play important roles elsevier inc rights reserved
machine learning approaches widely used identification neuropathology neuroimaging data however approaches require large samples suffer challenges associated multi site multi protocol data propose novel approach address challenges demonstrate usefulness autism brain imaging data exchange abide database predict symptom severity based cortical thickness measurements individuals autism spectrum disorder asd four different sites proposed approach consists two main stages domain adaptation stage using partial least squares regression maximize consistency imaging data across sites learning stage combining support vector regression regional prediction severity elastic net penalized linear regression integrating regional predictions whole brain severity prediction proposed method performed markedly better simpler alternatives better multi site single site data resulted considerably higher cross validated correlation score previously reported literature multi site data demonstration utility proposed approach detecting structural brain abnormalities asd multi site multi protocol abide dataset indicates potential designing machine learning methods meet challenges agglomerative data
novel switched flux surface mounted permanent magnet memory machine proposed incorporating flux memorizable concept structure employs temporary current pulse magnetize demagnetize aluminum nickel cobalt pms air gap flux regulated online extending high speed constant power region analytical hysteresis modeling method formulated implemented numerical nonlinear approximation hysteresis loops coupled time stepping finite element method perform analyses static transient flux regulatable characteristics preciseness coupling solution validity machine design verified experimental results
development technology people huge demand smart homes recent years variety smart home designs satisfied satisfy people new technology used construction called smart homes smart home offers many architectural features suitable human life situations smart life family care home security green building conventional smart home focused developing embedded devices meet needs today human machine interface smarter home therefore paper propose intelligent management model based cbr sda approach smart life recommendation system proposed paper example choosing clothes accessories finally smart home features using intelligent management model based cbr sda approach order improve users experiences various contributions
paper new method elastic optimal fractional order pid fir filters fopid fir controller design using hybrid population based algorithm presented use population based algorithm initial structure controller adjusted way designed controller fulfills control objective best way possible moreover control process controller feedback signals noise discretization taken consideration goal paper show influence using fir filters fopid controller structure accuracy present possibilities designing elastic controller structure using proposed hybrid population based algorithm proposed method tested typical control problem
study examined characteristics associated popularity social preference year old adolescents percent boys mainland china consistent findings countries popularity social preference moderately correlated overt aggression positively correlated popularity negatively correlated social preference prosocial behavior athletic skill dating academic achievement mutual friends positively associated popularity social preference effects prosocial behavior athletic skill dating greater popularity social preference strong correlations popularity prosocial behavior consistent confucian ideas moral leadership obligations high status individuals toward others cultural values also reflected association popularity academic achievement inconsistent findings china regarding relation aggression popularity may stem multiple factors including absence suitable chinese translation popularity
deflection nose new concept fast response control mode partial nose projectile deflect certain angle relative axis projectile body pressure difference emerges windward leeward side warhead generates aerodynamic control force control way high control efficiency good application prospect ammunition system nose deflection actuator based smart material structure makes projectile body morphing obtains additional aerodynamic force moment changes aerodynamic characteristics projectile flight process produces corresponding balance angle sideslip angle resulting motor overload adjusts flight moving posture controls ballistics finally realizes shooting range changing improves firing accuracy order study characteristics self adaptive control projectile numerical simulations conducted fluid dynamics software ansys fluent fin stabilized rocket projectile computed aerodynamics different nose delectation angle different mach number different angle attack compared aerodynamic characteristics different nose deflection angles results show nose deflection control bigger influence head rocket projectile caused asymmetry flow field structure make warhead differential pressure windward leeward surface increases resulting larger lift finally ballistics experiments done verification results offer theoretical basis self adaptive rocket projectile design optimization also provides new ideas methods field smart ammunition research
gist based processing proposed account robust false memories converging associates task deep encoding processes known enhance verbatim memory also strengthen gist memory increase distortions long term memory ltm recent research demonstrated compelling false memory illusions relatively delay invariant also occurring canonical short term memory stm conditions investigate contributions gist false memory short long delays processing depth manipulated participants encoded lists four semantically related words probed immediately following filled retention interval approximately min later surprise recognition test two experiments encoding manipulation dissociated stm ltm frequency phenomenology false memory deep encoding stm increases false recognition rates ltm confidence ratings remember know judgments similar across delays differ function processing depth results suggest shared unique processes underlie false memory illusions short long delays
tissue nerve injury induces widespread plastic changes periphery spinal cord cortex resulting chronic pain although many clinicians researchers extensively studied altered nociceptive signaling neural circuit plasticity spinal cord level effective treatments ameliorate chronic pain still insufficient last two decades rapid development macroscopic brain imaging studies humans animal models revealed maladaptive plastic changes pain matrix brain regions may subsequently contribute chronic pain among brain regions group concentrated many years primary somatosensory cortex help advanced imaging techniques found functional structural changes neurons glia well individual synapses cortex chronic pain taken together believed plasticity one causes chronic pain simple passive epiphenomenon following tissue nerve injury previously thought small review discuss relation plasticity cortex chronic pain based clinical trials experimental studies conducted field
global system level thermal hydraulic model demo tokamak fusion reactor currently development implementation suitable software politecnico torino including relevant heat transfer fluid dynamics phenomena affect performance different cooling circuits components integration consistent design model based object oriented approach using modelica language easily allows preserve high modularity required stage design first module global model simulate blanket cooling system able investigate different coolant options different cooling schemes adapted different blanket systems currently development breeding blanket project paper presents helium cooled pebble bed hcpb module demo blanket cooling loops system model model used compare different schemes cooling different components hcpb suggest improvements aimed optimizing pumping power required cooling system model used analyse pulsed scenario characteristic demo operation euratom published elsevier ltd rights reserved
water resources play important role demographic social economic development present study divides macroeconomic factors affect sustainable use water resources five major subsystems economy population water supply demand land resources water pollution management constructs feedback loop stock flow chart systems system dynamics model simulate water supply demand conditions future changes gap supply demand study designs different development programs simulate changes key variables changing value important model parameters found balanced development program achieve steady economic growth provide demographic dividend protect arable land resources also maximize sewage treatment rate improve reutilization efficiency water moreover find fundamental way bridge gap supply demand water resources improve water supply rather control demand elsevier ltd rights reserved
internet delivered interventions effective changing behavior research needed effective elements behavior change interventions moreover although anonymity one advantages using online context might also increase perceived distance participant intervention hence current study investigated whether behavior change methods self reevaluation anticipated regret used narrow perceived distance ultimately foster attitude change factorial persons design additional control group used resulting total conditions ranging first factor manipulated assessment self image cognitive affective combination second factor manipulated behavioral focus self image behavior without behavior without behavior post test measurements conducted immediately manipulation key finding current study behavior change methods self reevaluation anticipated regret impact changes attitude toward oral contraceptive use distance perceived participants despite null results current study contributes body evidence regarding self reevaluation anticipated regret integrated meta regressions experimental studies advance behavior change theory
subject paper detection mitigation data injection attacks randomized average consensus gossip algorithms broadly known main advantages randomized average consensus gossip fault tolerance distributed nature unfortunately flat architecture algorithm also increases attack surface data injection attack even though cast problem context sensor network security attack scenario identical existing models opinion dynamics called degroot model stubborn agents steering opinions group toward final state average network initial states specifically propose two novel strategies detecting locating attackers study detection localization performance numerically analytically detection localization methods completely decentralized therefore nodes directly act conclusions stop receiving information nodes identified attackers show simulation network often recover fashion leveraging resilience randomized gossiping reduced network connectivity
benefits bim effective decision making improved analysis easier access information simpler green building certification provide optimised solution sustainable design construction study proposes ifc based framework within integrated bim sustainable data model design stage building project life cycle present green building assessment tool gbat implements proposed model aids design team generation documentation necessary obtaining green building certification extracts necessary data bim models calculating green rating provides feedback evaluation sample project run green rating score table breeam materials category obtained validation model tool serves proof concept green data relevant breeam certification automatically processed used inform design elsevier rights reserved
excessive ethanol consumption alters neuroimmune system particularly impacts cytokine milieu cns cytokine dysregulation shown underlie addictive like behaviors including alcohol abuse however many studies focus primarily proinflammatory cytokine profile alcohol dependence current study furthers research determining impact excessive ethanol consumption interleukin interleukin activity model non dependent binge consumption called drinking dark paradigm furthermore ability modulate ethanol consumption tested using site directed pharmacology immunohistochemistry analyses determined ethanol decreased basolateral amygdala bla effect neither however altered central amygdala cea enzyme linked immunosorbent assays confirmed decreased amygdala serum suggesting changes cytokine paradigm restricted central nervous system finally bilateral infusions bla cea reduced binge like drinking corresponding blood ethanol concentrations without impacting either locomotor activity anxiety like behavioral correlates together data support idea alcohol abuse dysregulates specific anti inflammatory cytokines however ameliorating alcohol induced effects cytokines like may prove effective therapy curbing excessive consumption
main purpose semantic web expresses information intelligent forms enables better computers people work cooperation ontologies meaning providers play key role effort currently owl web ontology language used description ontology language main technique storing ontologies hand traditional relational database systems often used best mechanisms storing querying manipulating information benefits transaction management security reason need storing ontologies represented owl relational databases proposed therefore principles mapping owl concepts relational database schemas presented implemented tool purpose paper
paper describes approach recognizing person entering room using door accelerations approach analyzes acceleration signal time frequency domain domain two types methods developed feature based use features describe acceleration uses classification method identify person signal based use acceleration signal input finds similar ones order identify person four methods evaluated dataset entrances recorded people results show time domain methods achieve significantly higher accuracy compared frequency domain methods signal based method achieving accuracy additionally four methods combined combinations examined best performing combined method increased accuracy results confirm possible identify person entering room using door acceleration
objective cyclooxygenase cox inhibitors reduce prostaglandin synthesis disrupt essential reproductive processes ultrasound studies women demonstrated oral cox inhibitors delay prevent follicle collapse associated ovulation goal study determine oral administration cox inhibitor inhibit reproductive function sufficient efficacy prevent pregnancy primates study design cox inhibitor meloxicam vehicle administered orally proven fertile female cynomolgus macaques using one emergency contraceptive model three monthly contraceptive models emergency contraceptive model females bred proven fertile male days ovulation returned females home cage received days meloxicam treatment monthly contraceptive models females cocaged breeding proven fertile male total days beginning days ovulation animals received meloxicam treatment cycle days every day day day breeding period female assessed pregnancy results pregnancy rate meloxicam administration using emergency contraception model significantly lower pregnancy rate vehicle without meloxicam administered pregnancy rates three monthly contraceptive models consistent preventing pregnancy conclusions oral cox inhibitor administration prevent pregnancy single instance breeding primates meloxicam may ineffective regular contraception pharmacological inhibition cox may effective method emergency contraception women implications cox inhibitors interfere ovulation contraceptive efficacy drugs class directly tested study conducted nonhuman primates first suggest cox inhibitor may effective emergency contraceptive elsevier inc rights reserved
background cases sexual assault increasingly reported however nigerian researchers given adequate attention subject despite attendant social physical psychological consequences study assessed survivors characteristics circumstances assault treatment offered view reducing incidence well improving evaluation management methods retrospective review survivors case records lagos state university teaching hospital ikeja january december data analysed using epi info statistical software centre disease control prevention atlanta results new gynaecological cases period alleged sexual assault giving incidence among hospital gynaecological consultations case notes sufficient information statistical analysis years knew assailants majority neighbours assaults occurred neighbours homes victims presented hours assault although assaulted daytime teenagers likely raped day non teenagers night threat physical violence mostly used overcome victims seventy three point six percent human immunodeficiency virus hiv screening one positive onset post exposure prophylaxis hiv given eligible emergency contraception post menarcheal victims neither referrals psychotherapy forensic specimen collected record post assault conception hiv infection found follow conclusions adolescents remain vulnerable requiring life skills training protection survivors delay presenting care therefore public enlightenment benefits early interventions comprehensive care survivors use standardized protocols recommended
computer vision based autonomous fire suppression system real time feedback fire size spray direction presented paper system developed use firefighting robot close range localized fire suppression tasks enclosed environments probabilistic water classification method developed segmenting water spray pair cameras stereo processing performed localize points along spray path use yaw pitch angle estimation golden section search linear least squares optimization used determine optimal pitch angle spray position sampling time kalman filtering used remove noise angle measurements obtain better estimate current nozzle orientation decision tree used determine correct nozzle positioning mode using image feedback suppress fire accounts errors direction fire size suppression adjust nozzle based feedback implementation controller system able correct unknown disturbances causing erroneous targeting localized fire experiments presented initial nozzle angled correctly forced offsets system set initial spray position incorrectly order system correct suppression times ranged standard deviation average time total tests demonstrated performance system given forced offset initial nozzle orientation resulting error spray location fire target suppression times ranged mean standard deviation proposed system implemented robotic firefighting platform autonomously detect fire choose proper manipulation goal suppress full scale fires given disturbances causing erroneous targeting
transient osteoporosis hip toh characterized bone pain osteopenia bone marrow edema absence trauma present year old man chronic lymphocytic leukemia underwent fdg pet fdg pet demonstrated mildly fdg avid lymph nodes consistent chronic lymphocytic leukemia well fdg avidity right femoral head corresponding osteopenia rather focal lytic lesion demonstrated bone marrow edema consistent toh toh benign self limiting corresponding imaging may prevent mis diagnosis benign fdg avid toh severe hip processes tumors infection
major application domain vascular ultrasound carotid artery long subject anthropomorphic phantom design nevertheless trivial develop walled carotid phantoms compatible use integrative imaging carotid wall motion flow dynamics paper present novel phantom design protocol enable efficient fabrication walled carotid bifurcation phantoms high acoustic compatibility artery like vessel elasticity stenotic narrowing feature protocol first involved direct fabrication vessel core outer mold using computer aided design tools printing technology built parts used construct elastic vessel tube investment casting polyvinyl alcohol containing mixture agar gelatin tissue mimicking slab formed around vessel tube demonstration applied protocol develop set healthy stenosed carotid bifurcation phantoms plane wave imaging experiments performed phantoms using ultrasound scanner channel level configurability results show wall motion dynamics phantoms agreed pulse wave propagation elastic vessel pulse wave velocity measured common carotid artery flow dynamics matched expected ones healthy stenosed bifurcation recirculation flow jet formation observed integrative imaging vessel wall motion blood flow dynamics phantoms also demonstrated observed fluid structure interaction differences healthy diseased bifurcation phantoms findings show walled bifurcation phantoms developed new protocol useful vascular imaging studies individually jointly assess wall motion flow dynamics
super critical carbon dioxide promising thermodynamic cycle advanced nuclear reactors solar energy conversion applications dynamic control proposed recompression cycle accomplished input resistance temperature detector rtd measurements process fluid one challenges practical implementation cycle high corrosion rate component sensor materials paper develop mathematical model rtd sensing using eigendecomposition model radial heat transfer layered long cylinder show value rtd time constant primarily depends rate heat transfer fluid outer wall rtd also show typical material properties rtd time constant calculated sum reciprocal eigen values heat transfer matrix using computational model set rtd fluid thermophysical parameter values calculate value time constant thermowell mounted rtd sensor hot side precooler cycle eigendecomposition model rtd used future studies model sensor degradation impact control elsevier rights reserved
big data recently gained popularity strongly questioned relational databases universal storage systems especially presence analytical workloads result relational alternatives commonly known nosql sql databases extensively used big data primary focus nosql performance nosql databases directly designed physical level consequently resulting schema tailored dataset access patterns problem hand however believe nosql design also benefit traditional design approaches paper present method design databases analytical workloads starting conceptual model adopting classical phase design used relational databases propose novel design method considering new features brought nosql encompassing relational relational design altogether
paper outlines approach improving effectiveness reliability base isolation devices civil engineering structures undergo exceptional dynamic conditions strategy consists designing passive device way take account negligible soil structure interaction effects stage isolator designed way optimally tuned basis characteristics structure soil site anyway limits intrinsic effectiveness passive device completely overcome even embedding design influence soil filtering structural response therefore second stage active vibration device coupled basic isolator turn optimally designed minimizing structural response control costs overall presented approach definitively produces effective hybrid control base isolation already optimized specific structure soil passive component able concentrate active control effort frequency ranges required elsevier ltd rights reserved
context sports participation one leading causes concussions among nearly million high school student athletes objective describe epidemiology sport related concussion src high school sports academic years design descriptive epidemiology study setting aggregate injury exposure data sports high schools national athletic treatment injury outcomes network nation patients participants boy girl high school athletes academic years main outcome measure sport related concussion counts percentages rates per athlete exposures aes rate ratios rrs injury proportion ratios iprs reported confidence intervals cis rate ratios iprs cis containing considered significant results overall srcs reported among high school sports rate per aes football highest src rate aes followed boys lacrosse aes girls soccer aes src rate higher competition practice among sex comparable sports src rate higher girls boys however proportion srcs due player player contact higher boys girls ipr common symptoms reported among athletes srcs headache dizziness difficulty concentrating players srcs returned play within hours majority athletes srcs returned play days players symptoms resolve days less week conclusions findings provide updated high school src incidence estimates evidence sex differences reported srcs athletes srcs returned play within hours week injured players returned days despite smaller proportion symptoms resolve within week
purpose rural bypass critical access hospitals cahs elective inpatient outpatient surgical procedures studied residents choosing elective surgeries elsewhere local cah provides surgical services erode rural hospital financial base purpose research describe elective surgical bypass rate procedures commonly bypassed rural residents distribution volume among cahs offer elective surgical services factors predictive bypass methods sample elective surgery discharges created healthcare cost utilization project state inpatient databases state ambulatory surgery databases colorado north carolina vermont wisconsin frequencies procedures bypassed cah volume distribution performed logistic regression used model factors associated rural bypass elective surgical care findings rural bypass rate elective surgical procedures procedures bypassed operations musculoskeletal system eye digestive system annual volume distribution elective surgical procedures among cahs varied widely patients younger medically complex higher surgical risk private insurance higher odds bypass patients also likely bypass low volume hospitals conclusion rural hospitals consider developing surgical services performed electively outpatient basis attractive broader rural population cahs already offer elective surgical procedures yet still bypassed must examine mutable factors drive bypass behavior
climate change become global issue influencing human survival development urban carbon emission main factor fundamental building block city neighborhood basic space create truly sustainable community also starting point use low carbon ideas technologies address climate change promote construction low carbon city considering significance neighborhood planning reducing carbon emissions proposed low carbon neighborhood planning technologies six aspects layout planning traffic planning architecture planning design environment planning municipal engineering planning construction management moreover built indicator system low carbon neighborhood based technologies perspective carbon source control carbon sinks expansion used analytic network process anp analyze internal feedback obtain priorities system could used indicate low carbon degree provide measures improvements furthermore carried case study using proposed method neighborhood shandong province china practice proved system could promote sustainable low carbon development urban neighborhood provide government effective tool elsevier ltd rights reserved
erosion wear piping unavoidable degradation process oil gas industry causes pipe wall thinning leads economic losses potentially produce personal injuries mechanism pipe erosion remains poorly understood study focused predicting erosion tee junction various flow types fracturing operation failure analysis tee junction determined macroscopic features scanning electron microscope sem images allowed definition failure mode failure mechanism defined appeared significantly different considered traditional failure analysis fluid mechanics theory used build computational fluid dynamics cfd simulation method predict erosion tee junction model two phase flow tee junction indicated solid phase flow determined combined effects main tube flow flow inertia turbulent flow distribution erosion tee significantly different various flow types simulation results consistent results failure analysis model predicted local distribution erosion wear assist monitoring pipe walls prevent accidents reduce maintenance labor elsevier ltd rights reserved
heat transfer characteristics liquid lead bismuth eutectic lbe helium great significance two loop cooling system based accelerator driven system ads paper presents experimental study resistance characteristics heat transfer performance lbe helium experimental loop ads pressure drops lbe loop main heat transfer coupled heat transfer characteristics lbe helium investigated experimentally temperature lbe significant effect lbe thermo physical properties therefore considered prediction pressure drops results show overall heat transfer coefficient increases increasing helium flow rate decreasing inlet temperature helium increasing lbe reynolds number lbe inlet temperature promotes heat transfer performance main heat transfer thus overall heat transfer coefficient experimental results give insight flow heat transfer properties lbe helium heat exchanger helpful optimization ads system design copyright published elsevier korea llc behalf korean nuclear society
purpose paper aims examine effectiveness structural imaging aid diagnosis parkinson disease methods high resolution weighted magnetic resonance imaging performed patients idiopathic mean age years healthy subjects mean age years whole brain parcellated regions interest using composite anatomical atlases region volumes calculated three diagnostic classifiers constructed using binary multiple logistic regression modeling basal ganglion prior classifier data driven classifier iii basal ganglion prior data driven hybrid classifier leave one cross validation used unbiasedly evaluate predictive accuracy imaging features pearson correlation analysis performed correlate outcome measurement using best classifier disease severity results smaller volume susceptible regions diagnostic parkinson disease compared two classifiers basal ganglion prior data driven hybrid classifier highest diagnostic reliability sensitivity specificity accuracy furthermore outcome measurement using classifier associated disease severity conclusions brain structural volumetric analysis multiple logistic regression modeling complementary tool diagnosing
orthognathic surgery indicated treatment significant skeletal malocclusion normally prepared using conventional face bows combined two dimensional cephalometric analysis manually made splints recent developments oral imaging orthognathic surgeries planned using three dimensional computer aided design manufacturing cad cam software purpose study present protocol design printing final digital occlusal splints based planning orthognathic surgery validate accuracy splints virtual planning performed proplan software materialise required data exported matic software materialise design splints printed biocompatible material using objet connex printer stratasys validate accuracy splints cases patients undergoing orthognathic surgery analysed splints assessed clinically quantitatively comparing printed splints conventional analogue set clinical standard recording absolute distance errors three landmarks mean absolute distance error standard deviation falls within clinically accepted error margins absolute distance error ranged
investigated young children become sensitive one evolutionary important signal honest affiliative cooperative intent genuine duchenne smile altogether tested children years age series studies aimed mapping development children ability discriminate genuine fake smiles preference genuine smiles understanding genuine smiles linked prosocial behavior studies showed children ability discriminate answer questions different types smiles gradually improves ages years implicitly discriminating smiles gaze behavior age able identify genuine smiles explicitly verbal task age study showed year old children expect people displaying genuine smiles prosocial displaying fake smiles results demonstrate origins evolutionarily important form partner choice appear early development elsevier inc rights reserved
content documented portray limited range gender roles frequently depict fathers incompetent parents accordingly study explored whether first time expectant parents beliefs gendered family roles importance fathers child development related use participants individuals women men across united states expecting first biological child cohabiting heterosexual relationship participants completed online survey assessing weekly exposure exposure programs featuring fathers perceived realism use learn world beliefs fathers importance child development family gender roles zero order correlations indicated increased exposure general programs featuring fathers perceived realism stronger learning motives linked less egalitarian gender role beliefs women men among women heavier exposure general programs featuring fathers stronger learning motives correlated weaker beliefs fathers important child development multiple regression analyses however indicated attributing realism content uniquely predicted traditional gendered family role beliefs beliefs fathers less important child development across whole sample even among men low perceived realism greater exposure fathers linked weaker beliefs fathers important child development first time expectant fathers may especially vulnerable media messages father roles
inspection analysis synthesis method multiphase switched current circuits using signal graph sfg techniques presented sfg derived transistor level method primarily useful hand analysis design small medium size circuits filters decimators interpolators tables commonly used circuits corresponding sfgs circuits given make derivation easy fast sfgs overall discrete time transfer function also individual switching phases obtainable proposed method straightforward include non ideal effects finite output resistance mos transistors clock feedthrough settling error method also useful tool synthesis new circuits shown every low sensitivity switched capacitor circuit mapped directly low sensitivity circuit corresponding topology examples transformed circuits given two new double sampling integrators introduced john wiley sons ltd
continuously configurable weighted addition key function multivariate analog signal processing wavelength division multiplexed version weighted addition based microrings apply strengths photonic integration wideband photonic information processing multi wavelength networks toward new approaches ultrafast analog distributed processing letter experimentally demonstrate single channel functionality using ghz signal showing continuous range complementary weighting bank silicon microrings using feedforward controller balanced detection technique weight tuning accuracy dynamic range bits shown steps improve performance discussed systems microring weights weight banks could address hitherto unsolvable problems real time radio frequency processing high performance control
quantity based aggregation qba policy simple yet understudied scientific community qba policy stated follows given set sensitive objects limited number objects disclosed authors defined qba control model relational databases supporting projection selection queries single relations authors defined qba control model cadastral graph databases supporting point click queries work present paper seen interpretation graph datasets model defined generalization model defined arbitrary queries use prolog specify develop prototype model
optimal input design important step identification process order reduce model variance work optimal input design method finite impulse response type nonlinear systems presented optimization determinant fisher information matrix expressed convex optimization problem problem solved using dispersion based optimization scheme easy implement converges monotonically optimal solution without constraints optimal design realized time sequence imposing design lie subspace described symmetric non overlapping set realizable design found graph based method used order find time sequence realizes optimal constrained design methods illustrated numerical example results thoroughly discussed additionally computational speed algorithm compared general convex optimizer cvx elsevier ltd rights reserved
objective present research examine association lifetime cannabis use disorder cud current suicidal ideation lifetime history suicide attempts large diverse sample iraq afghanistan era veterans using battery well validated instruments expected cud associated current suicidal ideation lifetime suicide attempts even accounting effects sex posttraumatic stress disorder depression alcohol use disorder non cannabis drug use disorder history childhood sexual abuse combat exposure thus findings present study suggest cud may unique predictor suicide attempts among iraq afghanistan era veterans however significant limitation present study cross sectional design prospective research aimed understanding complex relationship cud mental health problems suicidal behavior among veterans clearly needed present time published elsevier ltd
borderline personality disorder bpd confers risk cardiovascular disease cvd present study used interpersonal perspective investigate potential mechanisms underlying association two undergraduate samples study replicated extended research demonstrating bpd features associated hostile somewhat submissive interpersonal behavior bpd features associated low social support high levels interpersonal conflict two well established risk factors cvd also hostile submissive behavior contributed association bpd features low social support study examined associations bpd features blood pressure responses two interpersonal stressors implicated models effects stress cvd specifically using laboratory tasks involving interpersonal conflict evaluative threat third undergraduate sample bpd features predicted elevated reactivity conflict evaluative threat heightened reactivity previously found predict development cvd interpersonal perspective may useful investigating mechanisms linking bpd cvd risk processes undermine otherwise protective social support heighten exposure reactivity interpersonal conflict may relevant regard elsevier ltd rights reserved
paper proposes original method time domain simulation mimo fractional systems based rational approximation using oustaloup method commensurate incommensurate fractional systems tackled main contribution propose straightforward formulae allowing approximate pseudo state space representation fractional system state space representation rational one whatever dimension original system whatever number poles zeros used approximation
study televisual violence deals two concepts real violence present informative broadcasts especially news fictional violence present movies television movies series real violence present news often justified television producers necessity warning make public defend avoid acts violence reality act presenting violence spectacular sensational manner economically motivated competition channels desire attract audience advertising determined presence violence spectacular dramatized manner first speculates human sensitivity order recur sophisticated ways make best artistic narrative linguistic iconic resources televisual discourse catharsis effect mechanism decoded daily life people confronted frustrating situations lead acts violence catharsis offers liberation frustrations imaginary participation acts violence aggression present television ones exposed negative effects media violence children according psychologist albert bandura capacity realizing something imitated knowledge values underlie discernment watching film television show child understand message differently comparison adult therefore watching big number acts violence induces child teenager idea violence normal way living world seen manichaeism confrontation positive negative character winner loser authors published elsevier ltd
advantages minimum phase systems control applications well known prior research shown non nmp system discretized system using either zero order hold zoh square pulse sample hold input shi paper investigates characteristics discrete time system obtained discretizing continuous time single input single output nmp system using different shis two new shis forward backward triangular studied addition square pulse numerical simulations adopted studying property resulting system function sample hold parameters simulation results show possible find smaller sampling period results system using proposed shis compared zoh markov cover system identification pseudorandom binary signal used hardware loop hil simulation study resistor capacitor filter used represent implementation error shi due unmodeled actuator dynamics hil simulation results show proposed shi scheme robust actuator modeling error properties systems three shis compared results show forward triangle shi best performance due robustness unmodeled actuator dynamics capability retaining property discretized system small sampling periods
paper presents design measurement results fully integrated optical sensor phase amplitude detection modulated optical signals mhz near infrared nir region use frequency domain spectroscopy instruments sensor consists nir sensitive photodetector monolithically integrated front end analog amplifier signal processing circuitry amplitude phase detection unmodified complementary metal oxide semiconductor cmos process high gain low noise differential transimpedance amplifier tia implemented amplify photocurrent signal amplitude phase resolution evaluated laser diode modulated mhz amplitude response exhibits resolution linearity measured amplitude output noise proposed phase detector detects degrees degrees phase difference measured average phase resolution degree output noise sensor implemented cmos technology consumes supply voltage
aid signal flow graphs analyzed flux control distribution linear metabolic pathways multiple feedback loops branched pathways shown flux control coefficients enzymes linear pathway multiple feedback loops evaluate modifying signal flow graph unregulated pathway step step fashion basis results obtained signal flow graphs principle superposition suggested calculating flux control coefficients linear pathway general pattern feedback inhibition using superposition principle possible determine flux control coefficients directly examination topology feedback loops metabolic pathway without drawing signal flow graph branched pathway control coefficients enzymes depend fluxes various branches addition enzyme elasticities show fluxes incorporated signal flow graph flux control coefficients found also describe systematic procedure converting signal flow graph simpler form may significantly reduce effort necessary calculating flux control coefficients modifications signal flow graph assessing relative importance enzymes flux control also discussed based findings signal flow graphs presented heuristic method determining flux control coefficients directly reaction sequence pathway without drawing signal flow graph present analysis applies metabolic pathways steady state
patients hcv genotype infection cirrhosis currently difficult cure report experience sofosbuvir daclatasvir sof dcv sofosbuvir ledipasvir sof ldv without ribavirin rbv clinical practice population multicenter observational study including cirrhotic patients infected hcv treated sofosbuvir plus nsa inhibitor may october total patients included treatment experienced decompensated meld score treatment sof dcv sof ldv overall received rbv rbv addition extension weeks higher sof ldv group respectively higher percentage decompensated patients treated dcv ldv overall svr sof dcv sof ldv svr achieved decompensated patients eleven treatment failures relapses one breakthrough rbv addition improve svr single factor associated failure achieve svr platelet count patients meld type nsa inhibitor impact svr adjusted thirteen patients serious adverse events including three deaths one therapy discontinuation higher decompensated patients patients infection cirrhosis svr rates high sof dcv sof ldv serious adverse events
tannin furanic rigid foams innovative polymeric materials made inexpensive organic ingredients usually produced via acid catalyzed polycondensation reaction furfuryl alcohol condensed flavonoids mimosa tannin bio friendly foams already proposed insulating material eco sustainable buildings green building technology important physical properties low thermal conductivity high fire resistance aim present study raman spectroscopic characterization tannin furanic rigid foams order establish tool complementary infrared spectroscopy comparing spectral signature precursor materials furfuryl alcohol polymerized furfuryl alcohol mimosa tannin discussion deals similarities differences spectral signatures carbon based materials still preserved organic nature tannin furanic foam similarities differences recently reported infrared spectra elsevier rights reserved
study objectives examine relationship self reported sleep parameters indicators resilience military population methods longitudinal analyses conducted using subjective data collected millennium cohort study questionnaires objective data military records included demographics military health deployment information subjective sleep duration insomnia symptoms collected study questionnaire resilience metrics included lost work days self rated health deployment frequency duration health care utilization early discharge military generalized estimating equations survival analyses adjusted demographic military behavioral health covariates models results presence insomnia symptoms significantly associated lower self rated health lost work days lower odds deployment higher odds early discharge military service early health care utilization self reporting long sleepers sleep per night similar findings except deployment outcome shortest sleep likely deploy conclusions poor sleep detriment service members health readiness leadership redouble efforts emphasize importance healthy sleep among military service members future research focus efficacy interventions promote healthy sleep resilience population
although winemakers rely density measurements supervise grape must fermentation results wine recent studies show refractive index also valid choice supervision purposes however dependence composition fermenting must especially temperature sample test makes difficult advance supervision automated stage lack correction data necessary adjust measurements made temperatures degrees common reference winemaking fermentation progresses requires measurements made degrees awkward real time monitoring scheme aiming providing solution issue present work studies dependence temperature must composition whole fermentation span model solutions composed fructose glucose ethanol glycerol along grape must samples extracted fermenter laboratory scale analyzed refractometry degrees acceptable temperature range fermentation proceed finally experimental data fitted second order polynomial resulting fold cross validation provide formula accurately yields temperature corrected values formula validated using portable low cost optoelectronic prototype sensing position laser spot resolution riu refractive index unit featuring temperature controller elsevier rights reserved
dynamic priority pollutant fate models developed assess appropriate strategies limiting release pps urban sources treating pps variety spatial scales different possible sources releases mapped release pattern release factors quantified detailed possible paper focuses link gathered sources data dynamic models urban environment link consists method quantitative structured storage temporal emission pattern information retrieval spatial emission source data gis covering studied urban area coupling gis based spatial emission source data temporal emission pattern information generation release time series feed dynamic sewer catchment model steps included main features dedicated software tool finally paper also illustrates method applicability generate model input time series generic pollutants cod bod addition priority pollutants elsevier ltd rights reserved
background antihyperglycemic drugs linked new onset atrial fibrillation naf however effect different classes antihyperglycemic drugs development naf elderly patients well studied study investigated association different classes antihyperglycemic drugs naf elderly patients materials methods nested case control study performed using database national health insurance programme taiwan participant aged years older naf assigned naf group whereas case sex age diabetes duration index date matched charlson comorbidity index score matched randomly selected participant without naf assigned non naf group multivariable logistic regression model used estimation odds ratios ors confidence intervals cis naf associated use different classes antihyperglycemic agents nonusers served reference group results identified cases controls risk naf adjusting sex age comorbidities concurrent medication higher among users insulin among nonusers patients took dipeptidyl peptidase inhibitors lower risk developing naf nonusers conclusions population use dipeptidyl peptidase inhibitor associated low risk naf insulin use associated significant increase risk naf long term follow
background polypharmacy highly prevalent residential aged care facilities racfs although polypharmacy sometimes unavoidable polypharmacy associated increased morbidity mortality objective identify prioritize range potential interventions manage polypharmacy racfs perspectives health care professionals health policy consumer representatives methods two nominal group technique ngt sessions convened august purposive sample clinicians researchers managers representatives consumer professional health policy organizations asked nominate interventions address prevalence appropriateness medication use participants asked prioritize five interventions suitable possible implementation system level results six potential interventions prioritized highest possible implementation clinical practice two interventions prioritized second highest top interventions rank order implementation pharmacist led medication reconciliation service new residents conduct facility level audits feedback staff health care professionals develop deprescribing scripts assist clinician resident discussion develop revise prescribing guidelines specific older people multimorbidity racfs implement electronic medication charts records better support medication advisory committees macs address medication appropriateness conclusion study prioritized range potential interventions may used assist clinicians policy makers develop comprehensive strategy manage polypharmacy racfs elsevier inc rights reserved
analytical performance veris hcv assay use new fully automated beckman coulter dxn veris molecular diagnostics system dxn veris system evaluated european virology laboratories precision analytical sensitivity specificity performance negative samples linearity performance hepatitis virus hcv genotypes evaluated precision sites showed standard deviation log lower level tested analytical sensitivity determined probit analysis specificity unique patient samples performance negative samples demonstrated detected results linearity using patient samples shown log assay demonstrated linearity upon dilution hcv genotypes veris hcv assay demonstrated analytical performance comparable currently marketed hcv assays tested across multiple european sites
transglutaminases calcium dependent enzymes catalyze formation epsilon gamma glutamyl lysine isopeptide bonds specific glutamine lysine residues transglutaminase isoforms present brain thought participate protein aggregation characteristic neurological diseases huntington alzheimer parkinson disease developed functional proteomics strategy biotinylated amine donor amine acceptor probes used identify transglutaminase substrates present brain bioinformatics analyses revealed brain substrates identified interacted huntingtin amyloid precursor protein alpha synuclein neurological disease significant canonical pathway associated substrates physiological relevance substrates identified mass spectrometry confirmed fact three actin beta tubulin neurofilament subunit polymerized neuronal cells cytosolic calcium concentration raised also showed situ immunolabeling substrates part protein aggregates found neurological diseases results strongly support idea crosslinking activity brain transglutaminase participates formation protein aggregates found diseases central nervous system elsevier inc rights reserved
background objectives according cognitive models social anxiety disorder sad negative rumination key maintaining factor vicious cycle social anxiety however scarcity research investigating treatment effects rumination social anxiety well key cognitive variables current study aimed determine effectiveness brief intervention range cognitive processes notably negative rumination additionally predictors negative rumination state anxiety also investigated methods participants diagnosis sad randomly allocated intervention control group participant initially completed trait state based measures intervention group also completing brief cognitive intervention one week later participants completed state anxiety cognitive measures speech task finally one week post speech task participants completed trait state based measures results brief cognitive intervention positive effects cognitive processes measured different time points study levels negative rumination remained stable predictors negative rumination state anxiety consistent cognitive models sad limitations brief nature intervention temporal stance intervention delivered one week speech may impacted outcomes conclusions cognitive technique potentially impact range key processes maintain sad however powerful tailored interventions needed address different processes play social situation socially anxious individuals elsevier ltd rights reserved
objective investigate effects different rearfoot orthotics postural sway unilateral stance lateral ankle sprain design repeated measures factor analysis variance postural sway length velocity frontal sagittal planes factors stance leg injured uninjured session within postinjury condition orthotic conditions setting university biomechanics laboratory patients fifteen collegiate athletes acute unilateral first second degree lateral ankle sprain interventions balance testing performed conditions shoe molded aquaplast orthotic lateral heel wedge degrees medially posted orthotic degrees laterally posted orthotic neutral orthotic main outcome measures postural sway length postural sway velocity frontal sagittal planes results significant main effects found side session orthotic condition dependent variables postural sway length velocity greater injured limbs compared uninjured limbs first sessions third session none orthotics significantly reduced postural sway compared shoe condition lateral ankle sprain conclusions rearfoot orthotics irrespective design posting ineffective improving postural sway lateral ankle sprain
psoriasis intensively studied recently numerous risk associated variants within susceptibility loci discovered estimates suggest genetic contribution psa psoriatic arthritis may higher psv psoriasis vulgaris yet work done latter due greater population prevalence test whether variants psv associated loci also related psa performed candidate loci association study chinese population genotyping performed massarray platform sequenom san diego usa single nucleotide polymorphisms snps reported evidences association psoriasis genotyped psa cases healthy controls collected chinese population data handling quality control association analysis performed using plink software snps showed convincing evidence association respectively ilb runx lce candidate genes regions combination snps best predictive model psa compared control test gene gene interaction conclusion assessed non hla psoriasis susceptibility loci psa cohort confirmed association three loci psa findings may help developing possible genetic markers predict psa
well known cells tissue display large heterogeneity gene expression due differences cell lineage origin variation local environment traditional methods analyze gene expression bulk rna extracts fail accurately describe heterogeneity intrinsic limitation cellular spatial resolution also information histology form tissue architecture organization lost process recently new transcriptome wide analysis technologies enabled study rna molecules directly tissue samples thus maintaining spatial resolution complementing histological information molecular information important understanding many biological processes potentially relevant clinical management cancer patients new methods generally comprise three levels analysis first level biochemical techniques used generate signals imaged different means fluorescence microscopy second level images subject digital image processing analysis order detect identify aforementioned signals third level collected data analyzed transformed interpretable information statistical methods visualization techniques relating spatial distribution tissue morphology review describe state art techniques used three levels analysis finally discuss future perspective fast growing field spatially resolved transcriptomics
hepatitis virus hcv major health concern worldwide leading cause liver related mortalities morbidities pakistan ranks second among countries endemic hcv infection similar million cases reported far hcv burden continuously rising pakistan mainly unsafe blood transfusions surgical procedures dental procedures untrained clinicians reuse syringes barbers ear nose piercing tools lack awareness hcv transmission routes among general high risk population major hurdle disease management hcv prevalence general population healthy blood donors ranges respectively whereas high risk groups hcv prevalence genotype prevalent pakistan followed genotypes along alarming number untypable viral genotypes local community mainly interferon based antiviral regimens used pakistan quite effective major prevalent genotype genotype showed best sustained virological response svr large number individuals show svr either infection nonresponder genotypes side effects due reasons need interferon free direct acting antivirals daas recently sovaldi sofosbuvir nsb inhibitor approved heavy discounted rate pakistan currently effective use showed good svr sovaldi plus ribavirin used alone along interferon treat different viral genotypes sovaldi future treatment regime pakistan genotype genotype infected individuals achieve best svr treatment prevalent viral genotypes approval daas ledipasvir discounted price required better disease management
breeding rice cultivars long lasting resistance rice blast fungus magnaporthe oryzae difficult identification new resistance genes essential loci associated blast resistance oryzae rice identified controlled environments single isolates loci may confer resistance small faction oryzae strains field however rice commonly attacked multiple strains research therefore needed identify loci confer resistance field field blast resistance identify loci associated field blast resistance lafbrs conducted genome wide association study gwas using rice diversity panel rdp cultivars cultivars evaluated field three major rice production areas china gwas identified lafbrs among novel three localized known blast resistance regions seventy four candidate genes identified lafbr regions encode receptor like protein kinases transcription factors defense related proteins using rice transcriptome data compared rice rice blast compatible interaction identified seven candidate genes significantly regulated five genes significantly regulated incompatible interaction among candidate genes identified lafbrs involved field resistance oryzae cultivars exhibit high levels resistance field growth chamber resistant cultivars snp markers identified study useful marker assisted selection new rice cultivars confer high levels resistance oryzae field populations
several prophylactic vaccines targeting herpes simplex virus hsv failed clinic demonstrate sustained depression viral shedding protection recurrences although vaccines generated high titers neutralizing antibodies nabs induction robust cells largely unreported even though evidence importance hsv antigen specific cells mounting animal models translational studies involving subjects active hsv specific immune responses developed subunit vaccine composed nab targets novel cell antigen tegument protein compared vaccine whole inactivated virus vaccine formaldehyde inactivated hsv hsv evaluated different formulations combination several toll inducing toll like receptor tlr agonists vivo mice tlr agonist cytosine phosphate guanine cpg oligodeoxynucleotide formulated squalene based oil water emulsion promoted robust functional hsv antigen specific cell responses high titers neutralizing antibodies demonstrating superiority vaccines adjuvanted monophosphoryl lipid mpl alum established hsv alone combination adjuvants well adjuvanted subunit vaccines successful induction nabs cell responses guinea pigs immunological responses coincident suppression vaginal hsv shedding low lesion scores reduction latent hsv dna dorsal root ganglia undetectable levels data support preclinical clinical development prophylactic hsv vaccines contain appropriate antigen adjuvant components responsible programming elevated cell responses importance millions people worldwide infected herpes simplex virus hsv date efficacious prophylactic vaccine met rigors clinical trials attempts develop vaccine focused primarily glycoproteins necessary hsv entry target antigens dominant neutralizing antibody response directed natural infection individuals asymptomatic infection exhibited cell responses specific hsv antigens observed symptomatic individuals describe first time immunogenicity profile animal models novel hsv cell antigen correlated asymptomatic hsv disease additionally vaccine candidates adjuvanted robust formulation cpg oligonucleotide delivered emulsion superior unadjuvanted mpl alum adjuvanted formulations eliciting robust cell mediated immune response blocking establishment latent viral reservoir guinea pig challenge model hsv infection
sparse representation based classifier src kernel sparse representation based classifier ksrc founded combining pattern recognition compressive sensing methods provide acceptable results many machine learning problems nevertheless classifiers suffer shortcomings instance src accuracy drops samples directional classes ksrc output declines data normally distributed kernel space paper introduces nonparametric kernel sparse representation based classifier nksrc generalized framework src ksrc first applies kernel samples overcome data directionality employs nonparametric discriminant analysis nda reduce data dimensionality kernel space alleviating concern data distribution type experimental results nksrc demonstrate superiority src ksrc lda equal superior performance respect ksrc pca synthetic four well known face recognition several uci datasets published elsevier
machining thick large complex aluminium parts redistribution initial residual stresses main reason machining errors dimensional variations post machining distortions errors lead rejection parts additional conforming operations increasing production costs therefore requirement predict potential geometrical dimensional errors resulting given machining process plan taking consideration redistribution residual stresses specific finite element tool allows predict behaviour work piece machining due changing geometry fixture workpiece contacts developed numerical tool uses material removal approach enables simulate machining parts complex geometries order deal industrial problems numerical tool developed parallel computing allowing study parts large dimensions paper approach developed predict machining quality presented first layer removal method used determine initial residual stress profiles airware alloy rolled plate introduced experimental results obtained analysed layer removal method simulated validate residual stress profiles test accuracy developed numerical tool machining part taken rolled plate performed experimentally numerically machining quality obtained compared showing good agreement thus validating numerical tool developed approach study also demonstrates importance taking account mechanical behaviour workpiece due redistribution initial residual stresses machining defining machining process plan
recent years support vector regression svr become emerging popular forecasting technique field machine learning however subjected model selection learning complexity especially massive data set size training dataset number search simultaneously reduce give insight inspiration designing effective accurate selection algorithm end paper tries integrate selection training subset model svr proposes nested particle swarm optimization npso inheriting model selection existing training subset based svr svr nested algorithm achieved adaptively periodically estimating search region optimal parameter setting svr complex svr involving large scale training data seen extensions svrs yielding nested sequence svrs increasing sample size uniform design idea transplanted modeling process convergence proposed model proofed using two artificial regression problems boston housing electric load new south wales empirical data proposed approach compared standard ones apso ots svr existing approaches empirical results show proposed approach select proper training subset parameter also better generalization performance fewer processing time elsevier rights reserved
sample adaptive offset sao adopted new loop filtering block high efficiency video coding hevc significantly increase compression efficiency especially sequences contain computer graphics content get optimum sao parameters exhaustive operations required huge amount samples encoder study work low cost high throughput vlsi implementation parameter estimation encoding phase proposed proposed novel architecture reduces cost terms gates count comparison prior work proposed design prototyped using cmos technology kgates bits sram maximum clock frequency mhz support real time kxk fps videos mhz
recent years paradigm optimization algorithms referred meta heuristics gaining attention means obtaining approximate solutions optimization problems quickly without special prior knowledge problems meta heuristics characterized flexibility implementation practical applications make use existing algorithms also revised algorithms reflect prior knowledge problems meta heuristic algorithms lack mathematical grounds however therefore generally require process trial error algorithm design parameter adjustment one resolution problem propose approach design algorithms mathematical grounds approach consists first constructing framework dynamic characteristics derived theoretically designing concrete algorithms within framework paper propose framework employs two following basic strategies commonly used existingmeta heuristic algorithms namely multipoint searching stochastic searching pseudo random numbers framework update formula search point positions given linear combination normally distributed random numbers fixed input term also present stability theory search point distribution proposed framework using variance search point positions index stability theory applied algorithm designed within proposed framework results used obtain control rule search point distribution algorithm also verify stability theory optimization capability algorithm based proposed framework numerical simulation
objective menopausal transition critical period associated physiologic changes influence women long term health longevity information however limited regarding factors influence age onset duration time onset final menstrual period methods analyzed data women four sites study women health across nation participated menstrual calendar substudy start identified missing covariate information participants included four racial ethnic groups african american white chinese japanese women completed daily menstrual calendars questions hormone therapy use monthly baseline measures included education economic strain menstrual cycle characteristics annual measures included height weight smoking status cox proportional hazards models used analyze data results adjusted median duration ranged years among oldest age onset quartile years among youngest age onset quartile cigarette smoking associated earlier onset shorter duration african american women longer duration white women body mass index associated later onset duration conclusions duration largely influenced age began earlier onset associated longer transition finding provides strong rationale developing improved markers onset early
shape description feature detection fundamental problems computer graphics geometric modeling among many existing techniques based geodesic distance proven effective providing intrinsic discriminative shape descriptors article introduce new intrinsic function three dimensional shape use shape description geometric feature detection specifically introduce intrinsic girth function igf defined closed surface point surface value igf length shortest nonzero geodesic path starting ending igf invariant isometry insensitive mesh tessellations robust surface noise propose fast method computing igf discuss applications shape retrieval detecting tips tubes plates constituent parts objects
paucity data emergency centers regarding prevalence recurrent assault injury prior psychological trauma psychosocial predictors assault injury presentation objective address gaps identify psychosocial needs injury prevention opportunities method patients presenting assault unintentional injuries recruited emergency centers ecs assessed injury history traumatic events mental disorders descriptive statistics computed predictors assault injury presentation recurrent assault injury identified using logistic regression univariate regression models employed identify significant variables entering multivariate models results majority participants male ages years median number lifetime traumatic events recurrent assault injury found injuries predicted lifetime traumatic events injury assault injury presentation significantly less likely female participants associated high levels witnessing community violence conclusion patients presenting assault injuries risk injury recurrence high levels past psychological trauma screened psychosocial risk research needed assess role past psychological trauma risk assault injury clarify treatment needs role based interventions injury prevention mental health requires increased recognition south african policy practice
cardiac ion channelopathies important cause sudden death young include long syndrome brugada syndrome catecholaminergic polymorphic ventricular tachycardia idiopathic ventricular fibrillation short syndrome genes encode ion channels implicated conditions leading widespread implementation genetic testing suspected channelopathies past half century researchers also identified systemic pathologies extend beyond arrhythmic phenotype patients ion channel gene mutations including deafness epilepsy cardiomyopathy periodic paralysis congenital heart disease coexisting phenotype cardiomyopathy influence evaluation management however prior recent molecular advances understanding recognition overlapping phenotypes poor review highlights systemic structural heart manifestations cardiac ion channelopathies including phenotypic spectrum molecular basis
micrornas mirs emerged important cancer biology mir conserved mirna investigated detail reported induced hypoxia inducible factor hif alpha contributory action progression breast hepatic pancreatic cancer however effects mir progression lung cancer subject debate present study found expression mir significantly upregulated non small cell lung cancer nsclc cells patients vivo however levels mir remained unchanged mes nci nsclc cell lines compared level normal hbe lung cell line however levels markedly upregulated nsclc cell lines conditions chronic hypoxia subsequently mir mimic transfected nsclc cell lines examine effect progression nsclc cells vitro data obtained using mtt cell counting kit assays revealed mir effect proliferation cells normal condition however proliferation promoted mild hypoxic conditions addition results transwell migration assay showed mir promoting effect nsclc cell migration conditions chronic hypoxia furthermore targetscan bioinformatics server untranslated region luciferase reporter assay indicated transcription factor nuclear factor alpha nfia target mir subsequent western blot analysis showed chronic hypoxia protein levels nfia tumor suppressor ccaat enhancer binding protein sharply reduced cells conclusion mir induced chronic hypoxia promoted proliferation migration nsclc cells chronic hypoxic conditions promotion may associated targeting nfia present findings may provide potential molecular target therapeutic treatment nsclc
caching popular contents mobile devices potentially improve quality service mobile users relieve traffic burden base station cellular networks paper jointly consider resource allocation cached contents distance two devices optimal device pairing problem centralized distributed cases central controller centralized case joint optimization problem device device caching channel allocation formulated weighted four uniform hypergraph model optimal solution problem maximum weighted matching dmwm hard unfortunately approach dmwm low complexity adopt greedy algorithm squareimp algorithm centralized case moreover distributed algorithms also designed caching problem synchronous asynchronous cases simulation results illustrate squareimp algorithm used get better transmission rate complexity greedy algorithm used case stringent latency requirement centralized dmwm problem sum rate distributed asynchronous algorithm close centralized greedy algorithm complexity device however simulation result synchronous algorithm slightly lower centralized algorithm device performs computational operations iteration therefore algorithms proposed paper used different cases solving optimal pairing channel allocation problem
field enquiry mentioned potential positive impact feed restriction health young rabbits objective information relates intake digestive health effects post weaning feed restriction strategy thus studied digestive health growth carcass parameters growing rabbit using monofactorial design produces quantitative linear reduction intake libitum group study performed simultaneously six experimental sites growing rabbits per treatment collectively caged weaning days age depending site slaughter days feeding programme applied followed restriction days weaning libitum till slaughter feed restriction period growth rate linearly reduced restriction level day percent intake reduction returning libitum intake days old compensatory growth higher feed efficiency occurred therefore impact feeding programme slaughter weight significant restriction relatively moderate weight loss restricted rabbits reached compared group whole fattening period feed restriction reduced linearly significantly feed conversion unit restriction carcass traits little affected feeding programme except slightly lower decrease dressing percentage mean units three restricted groups six experimental sites mortality morbidity always caused acute digestive disorders namely diarrhoea caecal impaction independent treatment mortality rate strongly varied according site weaning days group feed restriction mortality significantly lower restriction threshold meanly compared morbidity also significantly reduced two restricted groups favourable effect lower intake health persist returning libitum intake days slaughter since mortality morbidity significantly different among treatments feeding strategy thus represents double benefit terms feed costs lower losses young rabbits
review paper ill effects pharmaceuticals phas environment adsorption graphene oxide graphene oxide based based nanomaterials summarised discussed adsorption prominent phas discussed herein includes beta blockers atenolol propranolol antibiotics tetracycline ciprofloxacin sulfamethoxazole pharmaceutically active compounds carbamazepine analgesics diclofenac adsorption phas strictly depends upon experimental conditions adsorbent adsorbate concentrations temperature ionic strength etc understand adsorption mechanism feasibility adsorption process adsorption isotherms thermodynamics kinetic studies also considered except cases derivatives show excellent adsorption capacities phas crucial applications environmental pollution cleanup
psychological treatment mental health problems beginning undergo sea change driven widespread availability digital technology paper provide overview developments date pipeline describe various uses digital interventions consider likely impact clinical practice clinical services global dissemination psychological treatments note importance online clinics blended treatment digital assessment digital training authors published elsevier ltd
alzheimer disease white matter lesions wmls associated increased risk progression mild cognitive impairment mci dementia memory deficits least part linked cholinergic deficit investigated relationship betweenwmlload assessed scheltens scale cerebral acetylcholinesterase ache activity measured methyl piperidyl acetate pet neuropsychological performance patients mci due cognitively normal older participants periventricular nonperiventricular wml load negatively correlated ache activity groups memory performance depended periventricular total wml load across groups crucially ache activity predicted memory function better wml load gray matter atrophy age effects ofwmlload memory fully mediated byache activity data suggest contribution wml dysfunction cholinergic system mci due depends wml distribution pharmacologic studies warranted explore whether influences response cholinergic treatment elsevier inc rights reserved
study investigated reciprocal effects model rem children body fat self concept physical self concept objectively measured school physical activity different intensities grade four students age boys midwest region united states completed measures physical self concept body fat self concept wore accelerometers three consecutive school days beginning end one school year findings structural equation modeling analyses support reciprocal effects however children body fat self concept predicted future physical self concept moderate vigorous physical activity mvpa multigroup analyses explored moderating role weight status sex ethnicity sex ethnicity within rem findings supported invariance suggesting observed relations generalizable children across demographic groups links body fat self concept future physical self concept mvpa highlight self enhancing effects promote children health well
paper introduces binaural model localisation tracking moving sound source azimuth horizontal plane model uses nonlinear state space representation sound source dynamics including current position listener head state estimated via unscented kalman filter comparing interaural level time differences binaural signal semi analytically derived localisation cues spherical head model localisation performance model evaluated combination two different head movement approaches based open closed loop control strategies results show adaptive strategies outperform non adaptive ones able compensate systematic deviations spherical head model human heads
study conducted adrenal glands buffalo foetuses crown rump length crl investigate distribution mucopolysaccharides paraffin sections adrenal glands stained pas pas methods demonstrate presence neutral mucopolysaccharides nmps acid mucopolysaccharides nmps respectively nmps content high inner aspect capsule moderate wall large blood vessels capsule low definite foetal cortex low moderate zones medulla amps content low adrenal primordia moderate aggregating neuroectodermal cells amps content low capsule negative low definite cortex low moderate foetal cortex zones medulla distribution nmps amps varied different regions adrenal gland buffalo prenatal development
exhaust valve seat internal combustion engine reach high temperatures due hot gases exit engine exhaust port high temperature must decrease order avoid damaging combustion chamber engine high amount heat taken away exhaust valve seat contact transferred coolant therefore study heat transfer exhaust valve seat necessary paper capabilities neuro fuzzy approach namely anfis adaptive network based fuzzy inference system studied estimating rate heat transfer exhaust valve seat anfis model formed means input output data set taken experimental study inverse solution using conjugate gradient method cgm adjoint problem shown anfis architecture estimate heat transfer rate exhaust valve seat accurately means input output pairs obtained either actual system inverse method also shown based error analysis different algorithms gaussmf membership function provided best model estimating thermal contact conductance exhaust valve seat calculated root mean square error rmse anfis architecture gaussmf membership function compared experiment elsevier ltd rights reserved
north eastern region india although rich land water resources often suffers water scarce situation particularly non rainy season steep terrain conditions support conventional irrigation systems therefore micro irrigation system needs promoted micro irrigation systems maintaining uniformity application necessary achieve satisfactory crop yield maintaining system hydraulics challenge due terrain conditions equipment available study conducted observe various uniformity parameters selected emitters five different operating pressures viz study observed discharge variation selected emitters uniformity coefficient varied distribution uniformity statistical uniformity varied respectively emitter flow variation ranged range emitter exponent indicated values ranged values far manufacturer value study interpret emitting system needs tested adoption field ensure uniformity water application copyright john wiley sons ltd
neural networks becoming central several areas computer vision image processing different architectures proposed solve specific problems impact loss layer neural networks however received much attention context image processing default virtually choice paper bring attention alternative choices image restoration particular show importance perceptually motivated losses resulting image evaluated human observer compare performance several losses propose novel differentiable error function show quality results improves significantly better loss functions even network architecture left unchanged
strength materials mechanics deformable bodies part mechanics deals study relationship internal forces deformations arising real bodies changes shape size relation loads acting linkages physical properties material made general resistance materials engineering provides foundation allow together conditions stability balance calculate project work elements machines determining size verifying well designed suitable proposed objectives distinguish two perspectives scope subject firstly problem sizing secondly checking study scientific technological areas must characteristic providing practical results gives students opportunity test usefulness course solving everyday problems practice engineering important teacher uses obtain maximum attention interest students study strength materials done isolation must rely knowledge mechanics related study elasticity difference theory elasticity strength materials primarily focusing problem theory elasticity based accurate approaches means dispense simplified assumptions adopted strength materials subject elasticity strength materials erm usually given middle years degree compulsory subject engineering degrees well architecture agronomy etc vastness subject assumptions simplify every problem sometimes lack practical experiments support accuracy theoretical analysis provoke insecurity lack student motivation lack critical thinking essential engineer remedy lack motivation insecurity critical spirit propose creation working group work analyze stress state real piece comparing results three methods analysis first method would theoretical analysis second third experimental analysis numerical analysis variation results obtained method promote discussion analysis reasons results choice piece important complex piece would beyond bounds subject simple piece would produce significant variation results teaching experiment performed participation four teams groups student volunteers test whether introduction work subject generates positive educational outcome conducted student survey focusing three aspects acquisition knowledge increased motivation importance course future engineer survey provided different results students participated project students took part part analysis felt able discuss real part subject others much less understanding subject students surveys teaching real life problems give impression achieved main objectives
ruxolitinib dual janus kinase jak jak inhibitor used treat splenomegaly symptoms associated myelofibrosis current therapeutic options symptomatic include supportive care myelosuppressive therapy hydroxycarbamide janus kinase jak inhibitors particular ruxolitinib allogeneic stem cell transplantation remains potentially curative treatment younger transplant eligible patients still considered allogeneic stem cell transplantation however applicable small proportion patients increasing extensive experience efficacy safety ruxolitinib clinical trials real world practice drug shown benefit intermediate risk patients symptomatic splenomegaly related symptoms higher risk disease optimal use drug required maximise clinical benefit requiring understanding balance dose dependent responses dose limiting toxicities also increasing experience use ruxolitinib pre transplantation setting paper aims utilise several real life cases illustrate several strategies may help optimise clinical practice
concerning problems assessment scope present network security situation limited time space complexity high single source information low accuracy framework comprehensive factor weighted assessment network security situation proposed fully considers information fusion multi information sources multi level heterogeneous dynamically displaying network current security situation overall reflects network security situation accurately quantitatively finally taking full use instance data local network proposed method weighted factors network security situation assessment algorithm verified experimental results show correctness method
new method obtaining random bijective boxes based discrete chaotic map presented proposed method uses discrete chaotic map based composition permutations obtained boxes tested number criteria bijection nonlinearity strict avalanche criterion output bits independence criterion equiprobable input output xor distribution maximum expected linear probability results performance test show box presented paper good cryptographic properties advantage proposed method possibility achieve large key space makes suitable generation boxes larger values also method uses discrete chaotic map based composition permutations finite space domain need discretization continuous values chaotic map process generation boxes affected approximations kind
paper presents development artificial neural network ann based improved inductive signal conditioning circuit pressure transducer bellow sensor bellow elastic type mechanical pressure sensor deflection bellow due applied pressure must translated efficient electrical signal continuous monitoring wireless transmission digital readout ferromagnetic wire attached bellow part inductive coil arrangement gets deflected due applied pressure thereby changing self inductance coil amp inductive signal conditioning circuit oiscc designed produce voltage proportional changes self inductance oiscc voltage versus applied pressure exhibits considerable nonlinearity error due stray inductances component drifts ann modeling estimates compensates nonlinearity oiscc embedded unit used implementation ann learning process pressure transducer significant stability exhibited high linearity sensitivity psig respectively measuring range psig design experimental aspects technique reported
task scheduling one major issues achieve high performance distributed systems grid peer peer cloud environment generally two phases heuristics based task scheduling algorithms heterogeneous distributed computing systems hedcss phases task prioritization processor assigning respectively heuristic based task scheduling algorithms may use different policies assign priority subtasks produce different makespans heterogeneous computing system thus suitable scheduling algorithm one efficiently assign priority tasks order minimize makespan recently memetic algorithms mas used evolutionary population based global search approaches local search heuristic optimize complete problems recent studies mas discovered success wide variety real world problems since task scheduling problem complete paper new task scheduling algorithm cloud environment using multiple priority queues memetic algorithm mpqma proposed proposed method uses genetic algorithm along hill climbing assign priority subtask using heuristic based earliest finish time eft approach search solution task processor mapping basic idea approach using advantage increase convergence speed solutions implemented algorithm azure cloud service language experimental results set randomly generated graphs revealed proposed mpqma algorithm outperformed existing three task scheduling algorithms terms makespan fast convergence optimized solution
first televised debates presidential debates accentuated importance nonverbal behavior political competition president obama receiving widespread criticism disengaged arguably inappropriate communication style first debate investigate perceptual impact nonverbal expectancy violations study first employs experimental design examine consequence inappropriate leader displays operationalized nonverbal behaviors incongruent rhetorical setting theoretical explanations evaluative consequences inappropriate leader displays described light expectancy violations theory results repeated measures eye tracking experiment find support prediction inappropriate facial expressions increase visual attention source violation prompt critical scrutiny elicit negative evaluations findings explored qualitative analysis focus group responses key moments first third presidential debates discussion considers broader implications nonverbal communication politics expressive leader displays serve meaningful cues citizens making sense televised political encounters
wendelstein modular advanced stellarator commissioning phase max planck institute plasma physics greifswald germany focus numerical analysis shifted support machine design assembly toward preparation commissioning steps assessment possible field disturbances operational loads exploration operational limits paper emphasizes development evolution realization new analysis strategies well implemented numerical approaches electromagnetic thermal structural analyses remarkable results first comparisons measurements extended mechanical instrumentation system presented detail cover evacuation flooding cryostat plasma vessel first cooldown magnet system superconducting coil groups integral commissioning finally lessons learned transition phase highlighted might relevant large fusion machines
reports point increase problematic uses social networking sites may include swearing interpersonally deviant disadvantageous online behaviors etiology behaviors though still unknown relying models borrowed offline problematic behavior gambling substance abuse neurocognitive literatures theorize behaviors driven part elevated motor impulsivity poor sleep quality also growing concern modern society poor sleep quality strengthens effects motor impulsivity examined range problematic behaviors accounting stress effects test model conducted time lagged study involving young adults use social networking sites findings based structural equation modeling analyses reveal motor impulsivity drives problematic online behaviors poor sleep quality normative levels directly influence behaviors poor sleep quality augments effect motor impulsivity swearing interpersonally deviant disadvantageous online behaviors accounting stress effects results point possible etiological underpinnings problematic online behaviors serve springboard development interventions target factors elsevier ltd rights reserved
nowadays accurate identification natural frequencies damping ratios play important role smart civil engineering since used seismic design vibration control condition assessment among others achieve practical way required instrument structure apply techniques able deal noise corrupted non linear signals common features real life civil structures article two step strategy proposed performing accurate modal parameters identification automated manner first step obtained decomposed measured signals using natural excitation technique synchrosqueezed wavelet transform respectively second step estimates modal parameters solving optimization problem employing genetic algorithm based approach micropopulation concept used improve speed convergence well accuracy estimated values accuracy effectiveness proposal tested using simulated response benchmark structure measurements real eight story building obtained results show proposed strategy estimate modal parameters accurately indicating proposal considered alternative perform abovementioned task
describe case year old boy developed reversible cerebral vasoconstriction syndrome rcvs cerebellitis received intravenous immunoglobulin methylprednisolone treat cerebellitis however presented sudden severe headache vomiting generalized tonic clonic seizure brain magnetic resonance angiography mra initially revealed diffuse cerebral vasodilatations diffuse multifocal segmental vasoconstrictions developed several days later clinical symptoms gradually resolved several days absence specific therapy mra performed days symptom onset showed multifocal segmental vasoconstrictions resolved suggesting diagnosis rcvs imaging features rcvs include multifocal segmental vasoconstriction however case suggests diffuse cerebral vasodilatation may fact evident early stage disease elsevier ltd rights reserved
background despite well documented economic psychosocial burden irritable bowel syndrome ibs studies focused impact ibs daily activities study aims quantitate impairment daily activities among ibs patients evaluate relationship impairment ibs quality life psychiatric symptoms methods total participants meeting rome iii criteria ibs completed online research survey evaluating following variables impact ibs daily activities comorbid psychiatric diagnoses iii symptom severity quality life symptom specific cognitive affective factors related ibs key results sample reported high degree impairment due ibs sample reporting degree ibs related impairment least five different domains daily life rates impairment significantly higher participants met criteria anxiety depression panic disorder conclusions inferences study contributes existing literature demonstrating high level daily impairment among patients ibs particularly meet criteria anxiety depression panic disorder findings support importance integrated psychosocial medical care ibs patients highlight utility evaluation intervention behavioral avoidance impairment especially among exhibit signs symptoms psychiatric diagnoses
improve education regarding sustainability green buildings designed multiplayer people green building strategy game called gbgame deliver knowledge introduce applied technologies green buildings verify game learning effect conducted separate measurements using arcs motivation model paper based exam among students majoring architecture students divided experimental group played game control group underwent lecture based instruction results indicate game players stronger learning motivation attended lectures players learned game generally exhibited better learning effectiveness non players following cross validation discovered highly significant correlation learning effect players attention perception relevance confidence satisfaction game game system found attractive students implying effective instructional recreational material use green building education
objective estimate prevalence diabetes mellitus patients psoriatic arthritis psa comparison general population assess whether level disease activity time predicts development patients methods cohort analysis conducted patients followed large psa clinic prevalence patients compared general population ontario canada age standardized prevalence ratio spr calculated assessment risk factors time weighted arithmetic mean levels psa related disease activity measures assessed predictors development multivariable cox proportional hazards models used compute incident controlling potential confounders results total patients included analysis spr psa compared general population ontario patients included time event analysis patients observed develop based multivariable analyses tender joint count erythrocyte sedimentation rate predicted development conclusion prevalence higher patients psa compared general population patients elevated levels disease activity higher risk developing
cyclopropylmethy dimethoxy methoxymethylpheny ethyl tetrahydro pyran ylmethyl pyrazolo pyridin amine tosylate newly discovered selective corticotropin releasing factor receptor antagonist investigated effects wrap restraint stress induced defecation visceral pain rats oral pretreatment dose dependently decreased stool weights min wrap restraint stress significant effects observed doses however affect basal defecation doses contrast alosetron receptor antagonist decreased wrap restraint stress induced basal stool output dose rat visceral pain model subcutaneous injections alosetron significantly decreased number abdominal muscle contractions induced colonic distention suggesting drugs reduced visceral pain together results demonstrate potential effective therapy treatment irritable bowel syndrome lower risk adverse events constipation compared current clinically used receptor antagonist elsevier ltd rights reserved
objective study aimed evaluate effect sacrocolpopexy retropubic midurethral sling transvaginal tape tvt procedure overactive bladder oab symptoms null hypothesis concomitant sacrocolpopexy tvt exacerbate oab symptoms material methods prospective cohort study subjects apical anterior prolapse underwent robotic assisted sacrocolpopexy tvt without concomitant hysterectomy subjects completed standardized one year follow assess oab symptoms used urogenital distress inventory subscale questions question reponses questions based five point likert scale represents negative response symptoms represents problems patient answered higher likert scale either frequency urge incontinence question defined oab symptoms results sixty six subjects completed months visits preoperatively patients oab symptoms postoperatively patients oab symptoms patients postoperative oab lower patient global impression improvement pgi scores pgi oab pgi without oab conclusion found sacrocolpopexy concomitant retropubic midurethral sling contribute additive oab symptoms symptoms actually resolved women cohort presence postoperative oab contributes lower global impression improvement
considering difficult dealing symbolic expressions stored form strings put forward idea symbolic expression stored right thread binary tree minimize right thread binary tree symbolic expression could simplified right threaded binary tree represents symbolic expression traverse nodes order corresponding postfix expression traversal simplify expression algorithm minimizes tree also transforms tree expression string experiments show symbolic expressions simplified method know expression simplification one fundamental functions symbolic computation software also core software many studies algorithms symbolic expression simplification past however general algorithm found could simplify symbolic expression perfectly algorithm innovative research data structure symbolic expression simplification enormous significance taking various functions models account text makes use people thinking pattern skills simplify symbolic expression minimize right thread binary tree ldr traversal get traversing right thread binary tree order ldr symbolic expression postfix expression also called reverse polish expression dealing symbolic expression form postfix expression take account priority operators turns operator directly take front operands operate result ldr traversal tree makes possible simplify symbolic expressions text explain algorithm detail
study investigates program related investments pris mechanisms foundations use achieve charitable purposes generating moderate financial returns growing interest pris similar market based approaches among practitioners philanthropy recently examine internal external factors influence pris foundations quantitative qualitative analyses analyzing internal revenue service irs foundation center data find foundations financial human resources likely adopt pris initially also intensively engage pris foundations years older invest less money pris younger foundations findings interviews eight foundations reveal additional factors influencing foundations pri activities including staffing expertise board executive leadership changes legal economic environment sectoral trends peer networks interests needs pri recipients
authors present review foreign national studies effect computer games scenes violence aggressive behavior children adolescents analyzing evolution research area different approaches theories contemporary data special attention paid media habits people playing computer games containing scenes violence influence manifestations aggression real life well links personality characteristics
behind roll smart metering technologies lies belief personalised fact based information enhances energy awareness allows consumers modify behaviour amongst others practice theoretical accounts shown belief stems linear individualistic unrealistic interpretation behaviour change however emphasising energy use grounded socio material realities everyday life practice based studies fully considered role potential information reconfiguring domestic practices article takes smart grid pilot project netherlands case analyse interrelatedness policy interventions information flows domestic practices argue effects policy interventions domestic practices better understood seen part configuration heterogeneous practices helps understanding information accomplished put work identifying done improve smart grid interventions
aim aim study identify clinical features patients obstructive sleep apnea syndrome osas investigate impact continuous positive airway pressure cpap treatment nocturnal urine volume materials methods study enrolled patients moderate severe osas apnea hypoxia index data collected serum brain natriuretic peptide bnp level international prostate symptom score quality life ipss qol score overactive bladder symptom score oabss international consultation incontinence modular questionnaire nocturia qol iciq nqol score epworth sleepiness scale ess score frequency volume chart patients continued cpap treatment months included analysis results total patients men women completed study mean age years night time frequency void significantly decreased cpap treatment mean scores assessed ess ipss qol oabss iciq nqol significantly improved cpap mean diastolic blood pressure significantly decreased cpap treatment however significant change bnp level cpap treatment frequency volume chart hours undisturbed sleep total nocturnal voided volume nocturnal polyuria index significantly improved cpap treatment however voided volume mean voided volume night time change cpap treatment conclusion cpap treatment decreases night time urinary frequency reducing nocturnal urine production improves qol patients osas wiley periodicals inc
testosterone main male hormone testicle main gland produced whole life hormone production falls progressively clear relation hormone sexual behaviour hormone deficit causes alterations different organs systems low testosterone circulating values related many conditions welt increase mortality morbidity last years treatment testosterone avoid improve sexual disorders conditions promoted testosterone plasma level men diagnosed treated still dispute communication side effects treatment attracted health authorities attention different countries produced diverse reactions international scientific community late onset hypogonadism syndrome must diagnosed carefully never isolated hormonal analysis low testosterone values get often corrected without needing hormonal substitution treating causes give rise asociacion espanola andrologia medicina sexual reproductiva published elsevier espana rights reserved
epstein barr virus ebv primary infection usually asymptomatic sometimes progresses infectious mononucleosis occasionally people develop chronic active ebv infection caebv underlying immunodeficiency belongs continuous spectrum ebv associated lymphoproliferative disorders ebv lpd heterogeneous clinical presentations high mortality well established cell mediated immune response plays critical role disease evolution ebv infection recently high throughput sequencing hypervariable complementarity determining region cdr segments cell receptor cell receptor beta tcr beta emerged sensitive approach assess cell repertoire study fully characterized diversity peripheral blood tcr beta repertoire caebv patients ebv seropositive controls compared healthy ebv seropositive controls caebv patients demonstrate significant decrease peripheral blood tcr beta repertoire diversity basically including narrowed repertoire breadth highly expanded clones skewed cdr length distribution however significant difference caebv patients furthermore observed disease related preferences trbv trbj usage combinations well lots cell clones shared different groups unique overlapped involved public cell responses provide detailed insights divergent disease evolution
analytical calculation methods major components synchronous inductance tooth coil permanent magnet synchronous machines reevaluated paper inductance estimation different tooth coil machine compared one traditional rotating field winding machine accuracy analytical torque calculation highly depends estimated synchronous inductance despite powerful finite element method fem tools accurate fast analytical method required early design stage find initial machine design structure desired performance results analytical inductance calculation verified assessed terms accuracy fem simulation results prototype measurement results
aim study evaluate predictive value magnetic resonance imaging mri detecting thyroid gland invasion tgi patients advanced laryngeal hypopharyngeal carcinoma retrospective chart review patients advanced laryngeal hypopharyngeal carcinoma underwent mri scan total laryngectomy ipsilateral bilateral thyroidectomy past years mri findings compared postoperative pathological results sensitivity specificity positive predictive value ppv negative predictive value npv calculated among patients thyroid gland invasion postoperative pathological results mri correctly predicted absence tgi patients tgi patients sensitivity specificity ppv npv mri respectively diagnostic accuracy consideration high negative predictive value mri may help surgeons selectively preserve thyroid gland total laryngectomy reduce incidence hypothyroidism hypoparathyroidism postoperatively
developed novel computer aided diagnosis cad system uses feature ranking genetic algorithm analyze structural magnetic resonance imaging data using system predict conversion mild cognitive impairment mci alzheimer disease one three years clinical diagnosis cad system developed four stages first used voxel based morphometry technique investigate global local gray matter atrophy group compared healthy controls hcs regions significant volume reduction segmented volumes interest vois second vois used extract voxel values respective atrophy regions stable mci smci progressive mci pmci patient groups voxel values extracted feature vector third feature selection stage features ranked according respective test scores genetic algorithm designed find optimal feature subset fisher criterion used part objective function genetic algorithm finally classification carried using support vector machine svm fold cross validation evaluated proposed automatic cad system applying baseline values alzheimer disease neuroimaging initiative adni dataset smci pmci subjects experimental results indicated proposed system capable distinguishing smci pmci patients would appropriate practical use clinical setting
enthesitis related arthritis era category juvenile idiopathic arthritis jia common category india hla high prevalence era ilar classification includes exclusion criteria categories due cost routinely done undertook study assess prevalence hla era groups juvenile arthritis india consecutive patients jia era select patients categories recruited single tertiary care hospital span years hla tested using pcr five hundred eleven children studied era categories oligoarthritis polyarthritis systemic onset jia psoriatic arthritis undifferentiated prevalence hla highest era group correlated presence sacroiliitis prevalence oligoarthritis polyarticular rheumatoid factor positive arthritis negative polyarticular arthritis psoriatic arthritis unclassified systemic onset category twenty seven children change category jia per ilar owing hla testing positive commonly negative polyarthritis group six clinical features suggestive spondyloarthropathy high prevalence hla era though hla testing helps correct classification minority patients features suggestive spondyloarthropathy like back pain enthesitis sacroiliitis
combined cooling heating power cchp systems applied remote island proposed investigated work driven internal combustion engine energy demands investigated island covered cchp system without assistance electric grid four different cchp systems evaluated terms primary energy saving ratio carbon dioxide emission saving ratio annualized life cycle cost results show cases superior conventional system furthermore observed cchp system double effect absorption chiller offers better option compared adopting single effect absorption chiller circumstance supplemented cooling load high enough adopting electric chiller back favorable comprehensive consideration energy economic performance nevertheless true situation amount cooling load supplemented comparatively small could concluded best option among four systems one adopting double effect absorption chiller gas fired boiler elsevier ltd rights reserved
higher content salt soil key constraint crop productivity induction stress ethylene production aminocyclopropane carboxylate acc plant system one consequences salt stress responsible toxicity plant several transgenic plants developed expressing acc deaminase bacterial gene stress management strategy apart costly proposition lacks public acceptability main objective investigate plant inoculated acc deaminase producing bacterial endophyte effectively mitigate salt induced damage act alternative transgenics acc deaminase producing salt tolerant endophyte smr brachybacterium paraconglomeratum isolated roots chlorophytum borivilianum medicinal plant sensitive salt stress initially tested acc deaminase producing smr amelioration salt stress induced damage three different concentrations salt nacl salt stress selected study wider differences inoculated uninoculated plants noticed concentration nacl stress inoculated smr successfully protected borivilianum salt stress induced crop losses smr significantly alleviated negative impact salinity potential deamination acc precursor ethylene generation host chlorophytum roots leading decreased production stress ethylene delayed chlorosis senescence resulted improved yield plants apart reducing stress ethylene presence endophyte also affected phytohormone quantities like indole acetic acid abscisic acid plants also altered amount total leaf pigments biochemical compounds like proline malondialdehyde enhanced foliar nutrient uptake due outcomes appears acc deaminase producing endophyte enhance crop tolerance salinity stress important area explore
background progress diagnostic assessment made possible diagnose asd young age concurrently intervention research toddlers asd increased since past decade method study report five level meta analysis single subject experimental studies intended offer better insight types interventions effective toddlers age three risk asd results analysis revealed significant positive overall effect size found interventions home significantly effective compared settings significant moderators regarding intervention characteristics agent intervention duration weeks moderator effects study child characteristics found conclusions average interventions toddlers risk asd successful elsevier ltd rights reserved
article presented studies regarding cooling efficiency finned housing common servo machines studies performed considering three dimensional model housing hood electric vehicle motor mounted various positions moreover electric vehicle travels various velocities therefore study considers two parameters mounting position electric motor velocity fluid surrounding electric motor based results dependence two parameters housing cooling efficiency derived comparison analytical expressions usual cylinder cross sections also provided
elekta stereotactic body frame sbf device allows extracranial targets localized irradiated stereotactic coordinate system errors positioning body relative frame indirectly estimated image fusion multiple scans novel repositioning methodology based neurosurgical stealth technology presented whereby accurate patient repositioning directly confirmed treatment delivery repositioning performed four extracranial stereotactic radiosurgery patients radiotherapy simulation phantom setup error quantitatively measured fiducial localization confirmatory scan performed resulting image set registered initial scan quantify shifts gtv isocenter alignment confirmation using stealth took minutes phantom studies reproducibly accuracy phantom sbf alignment measured results four actual patients showed setup errors less using stealth station process rapid confirmation alignment treatment table possible
uncertainty monitoring core property metacognition allowing individuals adapt decision making strategies depending state knowledge although argued animals share metacognitive abilities humans seem possess ability explicitly communicate uncertainty others remains unknown whether capacity present early development whether emerges later ability verbally report one mental states using nonverbal memory monitoring paradigm show month olds monitor report uncertainty infants remember location hidden toy pointing indicate wanted recover experimental group infants given possibility ask help nonverbal communication forgotten toy location compared control group infants option decide infants given opportunity ask help used option strategically improve performance asking help used selectively avoid making errors decline difficult choices results demonstrate infants able successfully monitor uncertainty share information others fulfill goals
modularization involves breaking system discrete chunks communicate standardized interfaces rules specifications broad concept various interpretations meanings across research disciplines complexity scope module captured sufficiently clearly construction management engineering literature impact modularization across project phases fully explored articulated therefore main question addressed paper relates inherent meaning module context different phases building project addressing question paper empirically investigates use modularity construction projects situated italy germany brazil united kingdom findings research suggest design based operations based perspective modularity coexist need integrated view modularity across project lifecycle phases collaborative working designers site operators aim unifying definition module building projects proposed along practical guide help managers organize project activities effective modularization actual cost analysis various modularization strategies provides interesting avenue future research template proposed also requires wider testing wider range modules
main objective paper develop new technique detecting turn turn short circuit faults one two stator phases induction motor hence modeling turn turn short circuit fault one phase phase ground fault first novelty paper calculating phase currents faulty conditions strategy uses extracted features corresponding three phase current pattern space identification faulty phases severity fault outcome technique technique also capable detecting phase ground fault method requires current sensors available drive systems provide good controllability details machine design necessary experimental results included show ability proposed strategy detecting locating phase phases different faults load conditions
neurological emergencies represent medical take second cardiac respiratory cases however number neurologists lower developed nations quality improvement project aimed develop guideline optimise acute headache management non specialists informed findings survey audit doctors knowledge practice total doctors responded survey agreed guideline would useful knowledge important causes headache high lower others including cerebral venous sinus thrombosis cervical artery dissection consultant neurologist deemed acute headache presentations audited pre guidelines appropriate management guideline launch audit demonstrated proportion conclude investigation management acute headache requires optimisation guideline may help achieve
performance internal combustion engine directly related fuel quantity react oxygen air exothermic oxidation step also called combustion thus amount fuel introduced intrinsically linked air volume admitted cylinder air filling cylinder hence keeping air cylinder one important concepts predict simulations nevertheless phenomenon air filling depends many parameters also discharge coefficients impact piston presence near valves flow valve overlap investigated digital flow bench constructed reproduce series tests carried flow test bench functioning result reduction pressure paper engine studied single cylinder four stroke atmospheric type two valves thus idea paper treat case engines large valve overlaps small engines engines variable valve timing first traditional tests single valve performed forward reverse directions systematically tested ensure proper operation digital testing determine differences tests simulations case conventional configurations flow entire cylinder head intake valve cylinder piston exhaust valve system tested studied aim compare results obtained tests simulations valve overlap period significant differences highlighted rates measured one dimensional simulations tests noteworthy one dimensional code overestimated mass passing system valve overlap one fifth estimated mass passing system results obtained test rig
timely precisely identify attack behaviors network without dealing large number traffic features historical data training data important research work field network security paper firstly differences renyi entropy shannon entropy analyzed compared order capture network traffic changes exactly renyi entropy instead shannon entropy proposed measure selected traffic features ewma control chart theory used check renyi entropy time series detecting screening anomalies three kinds network attacks also analyzed characterized behavior feature vector attack identification finally feature similarity based method used identify attacks experimental results real traffic traces show proposed method good capability detect identify attacks less computation cost evaluate attack identification method conveniently approach proposed generate simulated attack traffics compared shannon entropy based method experiments simulation traffics show renyi entropy based method much higher overall accuracy average precision average true positive rate comparison indicates proposed method powerful performance detect attacks pca based method
microbial fuel cells mfc recently received increasing attention due promising potential sustainable wastewater treatment contaminant removal general contaminants removed either electron donor viamicrobial catalyzed oxidization anode removed cathode electron acceptors reduction contaminants also function electron mediators anode cathode previous studies done thorough assessment electron donors cathodic electron acceptors mediators well described oxygen widely used electron acceptor due high oxidation potential ready availability recent studies however begun assess use different electron acceptors diversity redox potential needs alternative efficient cathode reaction expanding mfc based technologies different areas aim review evaluate performance applicability various electron acceptors mediators used mfcs review also evaluated corresponding performance advantages disadvantages future potential applications select electron acceptors nitrate iron copper perchlorate mediators
millimeter wave observations sun never carried space based platform work presents feasibility study full disk ghz radiometer designed detect radio emission solar flares feasibility study carried frame adaheli advanced astronomy heliophysics mission whose phase funded italian space agency asi successfully completed december first flare radiation mechanisms introduced showing millimeter waves sensitive probe highest energy electrons accelerated solar flares fluctuation sun satellite radio path attenuation studied modeling ionosphere charged plasma finally science requirements system design presented instrument architecture based dish antenna deg offset feed receiver uses direct amplification configuration noise figure gain ppm gain stability target sfu radiometric resolution integration time achieved grz pre detection bandwidth
model based feedback control vortex shedding low reynolds numbers considered feedback signal provided velocity measurements wake actuation achieved using blowing suction cylinder surface using two dimensional direct numerical simulations reduced order modelling techniques linear models wake formed reynolds numbers models used design feedback controllers using loop shaping complete suppression shedding demonstrated single sensor arrangement three sensor arrangement robustness feedback controllers also investigated applying range design reynolds numbers good robustness properties seen also observed becomes increasingly difficult achieve acceptable control performance measured suitable way reynolds number increases
conventional reflow method convection oven principal step package assembly process order guarantee high productivity make full use self alignment package behavior especially warpage significant effects assuring package assembly reliability reflow process recent decades several techniques like shadow moire digital image correlation dic developed assist industry characterizing warpage requirement artificial speckles specimen surface inevitably reduces measurement accuracy contaminates specimen improve accuracy keep specimen clean novel situ warpage measurement method without surface treatment developed result demonstrated specimen reapplied manufacturing process measurement one sample assessed consistently different assembly process steps instead wasting samples assembly stage
accurate information basic vehicle parameters improve dynamic control functions vehicle methods online estimation mass rolling resistance aerodynamic drag coefficient yaw inertia longitudinal position centre gravity electric hybrid vehicle therefore proposed estimators use standard vehicle sensor set estimate electric motor torque additional sensors hence required assumptions made regarding tyre vehicle characteristics consequently information vehicle available estimator estimators evaluated using simulations experiments estimations mass rolling resistance aerodynamic drag coefficient based recursive least squares method multiple forgetting factors mass estimate converged within measured vehicle mass test cases sufficient excitation evaluated two methods estimate longitudinal position centre gravity yaw inertia also proposed first method based equations motion found sensitive measurement parameter errors second method based estimated mass seat belt indicators estimator robust reduces estimation error comparison obtained assuming static parameters results show proposed method improves estimations inertial parameters hence enables online non linear tyre force estimators tyre model based tyre road friction estimators used production vehicles
aim formulate paradigm capable reflecting innovative practices delivering tele medicare patients specifically focusing rural remote parts region tele health therapy practice area service delivery model surpasses practice areas improves access occupational medical therapy services work presents medicare service tele health therapy capable providing immediate appropriate treatment early stages medical emergencies urge providing health services instantly demand encourages researchers formulate system draw health graph patient foundation gathered parameters compare ideal graph formulated basis health form filled patient immediate relief graph tele health therapy attempts deliver initial treatment help diffusion mobile technology fuzzy database ambient intelligence tele health therapy diagnoses person near real time prescribes initial level medication comforting patient recovering stable state till actual medical aid reach tele health therapy addresses apprehension anything person sure health take opportunity ask questions raise concerns may
background compression performed postoperatively intention minimising side effects bleeding haematoma area operation well postoperative oedema pain compression stocking manufacturing incorporated addition skin care products yarn material recent years however benefits products remain controversial addition length compression stocking disputed terms effectiveness effectiveness investigated present study method surgery patients indication surgical removal varicose veins randomly divided four groups different types compression stockings case group patients received knee length stocking length thigh length stocking length knee length stocking aloe vera thigh length stocking time surgery one week weeks surgery skin moisture measured objective parameter quality life determined using freiburger questionnaire quality life veinous disease flqa benefit patients evaluated using patient benefit index pbi subjective parameters investigated free text questionnaire surgery extent haematoma determined using point count method result surgery post operative times flqa decreased significantly corresponding better quality life pbi increased group aloe pruritus significantly lower comfort skin moisture increased skin condition significantly improved extent haematoma decreased regardless length stockings conclusion benefit skin care additive observed finding objectively confirmed based skin moisture multifactorial quality life affected skin care additive thigh length compression stockings provide measurable benefit
polar bears ursus maritimus managed nations occur canada greenland denmark norway russia united states using discrete subpopulations canada polar bears harvested throughout range several subpopulations managed one jurisdiction therefore recent management focused ensuring sustainable polar bear harvests consequently subpopulation harvested bears removed geographic boundaries subpopulation must correctly identified however boundaries southern hudson bay subpopulation verified using satellite radio telemetry data sea ice duration already declined hudson bay james bay duration distribution sea ice predicted decline greatly next century therefore important document current habitat use patterns assess potential impacts climate change used probabilistic approach describe utilization distribution subpopulation based data adult female bears fitted satellite collars assessed whether currently accepted boundaries represent population utilization distribution conclude boundaries reflect current spatial distribution adult female bears subpopulation analysis provides benchmark compare future distribution habitat use subpopulation response effects climate change identifies future research needs investigate polar bear distribution james bay area near boundary western hudson bay management zones
reason variability light pedestrians appearance hard camera obtain clear human figure person identification different cameras difficult visual recognition task paper novel approach called attribute learning based distributed deep convolutional neural network model proposed address person identification task shows attributes namely mid level medium classes features obtained automatically employed identify person semantics author topic model used mapping category besides considering ability operate raw pixel input without need design special features deep convolutional neural network employed generate features without supervision attributes learning model overcome model weakness computing speed parallelized implementations distributed parameter manipulation attributes learning employed attribute learning based distributed deep convolutional neural network model experiments show proposed approach achieves state art recognition performance viper data set good semantic explanation copyright john wiley sons ltd
given documented gender differences risk factors manifestations violence researchers advocated gender sensitive approaches violence risk assessment study compares male female forensic psychiatric patients array demographic clinical behavioral legal variables gain clearer understanding prevalence different risk factors types violence population investigate interrater reliability item utility historical clinical risk management hcr examine whether individual hcr items exhibit differential relationships tool summary risk rating across gender women carried diagnosis borderline personality disorder whereas antisocial personality disorder substance use problems extensive criminal histories often noted men clinical differences reflected distribution hcr item subscale scores across gender interrater reliability excellent especially women lack personal support increased odds deemed high risk women greater extent men discuss utility structured professional judgment tools hcr women consider importance gender sensitive approach risk assessment
detailed information distribution airway diameters bronchoconstriction situ required understand regional response lungs imaging studies using computed tomography previously measured airway diameters changes response bronchoconstricting agents manual measurements used severely limited number airways measured per subject hence detailed distribution heterogeneity airway responses unknown developed applied dynamic imaging advanced image processing methods quantify compare hundreds airways vivo method based applied house dust mite sensitized control mice intravenous methacholine mch infusion airway diameters measured pre post mch challenge results compared demonstrate distribution airway response throughout lungs mechanical ventilation forced oscillation testing used measure global response lung mechanics found marked heterogeneity response paradoxical dilation airways present airway sizes probability paradoxical dilation decreased decreasing baseline airway diameter affected pre existing inflammation results confirm importance considering lung entire interconnected system rather collection independent units hoped response distribution measurements help elucidate mechanisms lead heterogeneous airway response vivo new noteworthy information distribution airway diameters bronchoconstriction situ critical understanding regional response lungs developed imaging method quantify compare size hundreds airways vivo bronchoconstriction mice results demonstrate large heterogeneity constriction paradoxical dilation airways confirming importance considering lung interconnected system rather collection independent units
complex systems increasingly involves devices sensors smart phone interconnected objects computers results called ambient systems one today challenges framework ubiquitous computing concerns design ambient systems major difficulty propose compositional adaptation devices appear despair time wcomp environment prototyping dynamic execution environment ambient intelligence applications including management mechanism allowing extensible interference devices new approach based definition strategies validated using discrete event simulation proposed order take account conflicts compositional adaptation devices ambient systems defined validate using devs discrete event system specification formalism integrated prototyping dynamic execution environment ambient intelligence applications proposed solution allows designers ambient systems define optimum matching components one pedagogical example presented switch lamp system proof proposed approach
describe general framework adding values two approximate counters produce new approximate counter value whose expected estimated value equal sum expected estimated values given approximate counters best knowledge first published description algorithm adding two approximate counters work implementation details five different kinds approximate counter provide optimized pseudocode three present proofs variance counter value produced adding two counter values way bounded fact worse much worse variance value single counter total number increment operations applied addition approximate counters useful massively parallel divide conquer algorithms use distributed representation large arrays counters describe two machine learning algorithms topic modeling use millions integer counters confirm replacing integer counters approximate counters effective speeding gpu based implementation cpu based nearly well reducing memory requirements without degrading statistical effectiveness
arid semi arid areas rainfall often characterized strong spatial temporal variability environmental factors combined sparsity measurement networks developing countries constitute real constraints water resources management recent years several spatial rainfall measurement sources become available trmm data tropical rainfall measurement mission study trmm version product evaluated using rain gauges measurements stations oum bia oer basin located center morocco relevance trmm product tested direct comparison observations different time scales daily monthly annual results show satellite product provides poor estimations rainfall daily time scale giving average pearson correlation coefficient average root mean square error rmse however accuracy trmm rainfall improved temporally averaged monthly time scale rmse annual time scale rmse moreover improved correlation observed data obtained data spatially averaged watershed scale therefore monthly annual time scales trmm data useful source rainfall data water resources monitoring management ungauged basins semi arid regions
grid computing emerged new field distinguished conventional distributed computing focuses large scale resource sharing innovative applications cases high performance orientation grid serves comprehensive complete system organizations maximum utilization resources achieved load balancing process involves resource management effective load distribution among resources therefore considered important grid systems grid dynamic distributed load balancing scheme provides deadline control tasks due condition deadline failure developing deploying executing long running applications grid remains challenge deadline failure recovery essential factor grid computing paper propose dynamic distributed load balancing technique called enhanced gridsim load balancing based deadline failure recovery egdfr computational grids heterogeneous resources proposed algorithm egdfr improved version existing egdc perform load balancing providing scheduling system includes mechanism recovery deadline failure gridlets extensive simulation experiments conducted quantify performance proposed load balancing strategy gridsim platform experiments shown proposed system considerably improve grid performance terms total execution time percentage gain execution time average response time resubmitted time throughput proposed load balancing technique gives better performance egdc case constant number resources whereas case constant number gridlets gives better performance egdc
background amygdala large grey matter complex limbic system may contribute neurolimbic pain network migraine however detailed neuromechanism remained elucidated objective study investigate amygdala structural functional changes migraine elucidate mechanism neurolimbic pain modulating migraine pathogenesis methods conventional mri structure images resting state functional mri performed normal controls patients episodic migraine patients chronic migraine amygdala volume measured using freesurfer software functional connectivity bilateral amygdala computed whole brain analysis covariance performed individual maps among groups results increased left amygdala observed compared decreased right amygdala revealed compared increased bilateral amygdala observed compared correlation analysis showed negative correlation score sleep quality normal mild sleep disturbance moderate sleep disturbance serious sleep disturbance increased strength left amygdala compared positive correlation score sleep quality increased strength left amygdala compared clinical variables showed significant correlation altered amygdala conclusions altered functional connectivity amygdala demonstrated neurolimbic pain network contribute pathogenesis chronicization
hepatocellular carcinoma hcca primary malignancy liver many different proteins involved hcca including insulin growth factor igf signal transducers activators transcription stat stat mothers decapentaplegic homolog smad fragile histidine triad fhit selective internal radiation therapy sirt etc present study based bioinformatics analysis fhit protein order understand proteomics aspect improvement diagnosis disease based protein different information related protein gathered different databases including national centre biotechnology information ncbi gene protein online mendelian inheritance man omim databases uniprot database string database kyoto encyclopedia genes genomes kegg database moreover structure protein evaluation quality structure included easy modeler programme hence analysis helped gather information related protein one place also analysed structure quality protein conclude protein role carcinoma
regions lacking socio economic data pairing satellite imagery participatory information essential accurate land use cover lulc change assessments village scale papua new guinea compare swidden lulc classifications using remote sensing analyses alone analyses combine participatory information remotely sensed data participatory remote sensing prs methods include participatory land use mapping household surveys validation image analysis combination remotely sensed data classifications swidden area made using remote sensing analysis show swidden areas average two half times larger land managers reported classifications made using remote sensing analysis homogeneous lack discrimination among swidden plots fallow land non swidden vegetation information derived prs methods allows amend remote sensing analysis result swidden areas similar actual swidden area found ground truthing conclude prs methods needed understand swidden system lulc complexities
despite improved awareness work related diseases preventive measures many workers still high risk developing occupational hypersensitivity airway diseases stems lack knowledge bioaerosol composition potential effects human health recently archaea species identified bioaerosols raising possibility play major role exposure related pathology specifically methanosphaera stadtmanae mss methanobrevibacter smithii mbs found high concentrations agricultural environments respiratory exposure crude extract demonstrates immunomodulatory activity mice nevertheless knowledge specific impact methanogens exposure airway immunity potential induce airway hypersensitivity responses workers remains scant analysis lung mucosal response methanogen crude extracts mice demonstrated mss mbs predominantly induced airway inflammation typical type hypersensitivity response furthermore response mss associated antigen specific igg igg production however despite presence eosinophils mss exposure weak response airway hyperresponsiveness observed finally using eosinophil mast cell deficient mice confirmed cells dispensable response mss although eosinophils likely contribute exacerbation inflammatory processes induced mss crude extract exposure conclude mss induces clear type hypersensitivity lung response potential harmful workers frequently exposed methanogen preventive measures taken avoid chronic hypersensitivity disease development workers
nonlinear sliding mode slm controller based maximum jerk time optimal step response developed control servo solenoid valves exhibits performance advantages compared traditional pid controller however experiments shows responses slm control jerk constraint largely vary different damping loads leading large overshoot breakdown working conditions large viscous damping coefficient thus improved slm controller developed paper deal existing drawbacks novel nonlinear slm surface proposed taking account spool acceleration jerk limitation firstly nominal model servo solenoid valve built linearizing dynamics null position system identification carried achieve model parameters variation ranges subsequently valve constraints power limitation analyzed frequency response identified model comes maximum available velocity acceleration jerk finally improved slm control algorithm proposed novel slm surface considers maximum plus jerk maximum minus jerk maximum acceleration experimental studies conducted results show improved slm controller acceleration jerk constraints achieve continuous stable sliding mode state realize time optimal step response valve exhibit strong disturbance rejection abilities elsevier ltd rights reserved
leading following defined parse deliberately innovating potent engaging persistently pursuing excellence indivisible unpredictable ever changing cocreation parse noted processes forming essence leading following require commitment risk taking acknowledging ambiguity respecting others vigilance bond members society nursesan expectation nurses provide care individuals families communities nursing profession potential create meaning healthcare yet fully realized
experiences individuals mental illness addictions frequently present hospital emergency departments eds rarely explored study reports findings self reported quantitative surveys depth qualitative interviews frequent users mental health substance use challenges large urban centre participants presented hospital mental health alcohol drug use physical health concerns described visits unavoidable appropriate despite feeling stigmatized hospital personnel discharged without expected treatment supporting population may require alternative service models attention staff training acute community settings
experimental intervention studies constitute current dominant research designs autism education field designs based knowledge transfer model evidence based practice research conducted researchers transferred practitioners enable implement evidence based interventions research designs contribute important knowledge lead gap research evidence may prescribe happens practice concomitant disparity priorities researchers practitioners paper discusses findings esrc funded shape project adopted different model evidence based practice focusing knowledge construction pupils teachers speech language therapist parent three different school communities investigated creative ways children social communication skills could enhanced technology use participatory methodology digital stories used method enable engagement practical realities classroom empower practitioners construct share authentic narratives participants articulated precise knowledge learning opportunities afforded pupils quality interactions mediated technologies evidenced digital stories shape project shows feasible develop methodologies enable genuine knowledge construction school practitioners parents pupils construction could offer realistic opportunities pedagogical emancipation innovation evidence based practice alternative currently dominant narrow model knowledge transfer
introduction study aimed evaluate efficacy safety solifenacin older patients overactive bladder oab materials methods observational data patients aged years prescribed flexible dose solifenacin oab collected offices german general practitioners baseline week data included type severity oab symptoms adverse events quality life change cognitive function per mini mental state examination mmse results mean age patients years decrease observed oab symptoms including reduction urinary urgency micturition episodes per change mean mmse scores apparent week adverse events treatment discontinuations low respectively conclusion solifenacin well tolerated oab symptoms declined week relevant effect solifenacin cognitive function observed elderly population karger basel
despite extensive research alternative methods internal combustion engine expected remain primary source vehicular propulsion foreseeable future still significant opportunities improving fuel efficiency thus directly reducing harmful emissions consequently mitigation thermal frictional losses gradually become priority piston cylinder system accounts major share losses well emissions therefore need integrated approach particularly predictive nature essential paper addresses issue particularly role cylinder liner temperature affects thermal frictional performance piston cylinder system study focuses top compression ring whose critical sealing function makes major source frictional power loss critical component guarding blow harmful gasses integrated approach hitherto reported literature study shows cylinder liner temperature critical mitigating power loss well reducing hydrocarbon nitrogen oxide nox emissions compression ring cylinder liner conjunction results imply existence optimum range liner working temperature independent engine speed least studied cases minimise frictional losses combined study nox emissions control liner temperature help mitigate frictional power loss reduce emissions author published elsevier ltd
mutations gba lrrk genes account one third prevalence parkinson disease ashkenazi jews non manifesting carriers nmc mutations represent population risk future development patient carry mutations gba gene demonstrates significant cognitive decline compared idiopathic patients assessed cognitive domains using fmri among nmc lrrk gba mutations better understand pre motor cognitive functions populations twenty one lrrk nmc gba nmc non manifesting non carriers nmnc participated study evaluated using standard questionnaires scanned performing two separate cognitive tasks stroop interference task back working memory task cerebral activation patterns assessed using whole brain predefined region interest roi analysis subjects well matched demographic clinical characteristics stroop task spite similar behavior gba nmc demonstrated increased task related activity right medial frontal gyrus reduced task related activity left lingual gyrus compared lrrk nmc nmnc addition gba nmc higher activation patterns incongruent task compared nmnc left medial frontal gyrus bilateral precentral gyrus whole brain differences noted groups back task paired cognitive task related performance gba nmc lrrk nmc nmnc could indicate higher activation patterns incongruent stroop condition among gba nmc compared lrrk nmc nmnc may represent compensatory mechanism enables adequate cognitive performance
epidemiological data consumption flavonoid containing food points notion secondary plant metabolites may favour healthy ageing aim present paper review literature lifespan extension flavonoids worms flies mice studies worms flies experienced lifespan extension supplemented flavonoids either extracts single compounds studies mutant worms flies give hints gene products may regulated flavonoids consequently enhance longevity discuss data considering putative mechanisms may underlie flavonoid action energy restriction like effects inhibition insulin like growth factor signalling induction antioxidant defence mechanisms hormesis well antimicrobial properties however remains uncertain whether human lifespan could prolonged increased flavonoid intake
current smart devices phones tablets etc integrated light sensors used adjust screen brightness automatically according ambient light variations light sensors become sensitive able read even rgb light components information however accessed without requesting user special access rights application also available background running services used fitness applications application therefore exploit lack security track user environment luminance information originating example screen without user knowledge paper investigates process obtaining sensor data multiple operating systems usability data related type light sensor distance light source outlines possible data flow remote processing application gathers information originating light sensor uses detect reference video source shown user screen
incremental sheet forming isf recently developed manufacturing technique isf forming done applying deformation force motion numerically controlled single point forming tool clamped sheet metal blank single point incremental sheet forming spisf also known die less forming process die required fabricate component using process day widely accepted rapid manufacturing sheet metal components formability spisf process improves adding intermediate stages known multi stage spisf mspisf process however forming mspisf process intermediate stages stepped features generated paper investigates generation stepped features simulation experimental results effective mspisf strategy proposed remove eliminate generated undesirable stepped features
propose alternative approach treat problems axial spherical symmetry main characteristic consists using cartesian coordinates instead curvilinear coordinates usual end derive general mathematical expressions giving spatial derivatives tensors arbitrary order along direction normal arbitrary meridian plane systems axial symmetry along two orthogonal directions normal arbitrary radius systems spherical symmetry relations allow reduction initial three dimensional problem domain lower dimension two axial symmetry one spherical symmetry keeping cartesian coordinates within domain method illustrated flow newtonian fluid two coaxial cylinders couette cell weissenberg effect viscoelastic fluids flow complex fluids like liquid crystals
past research investigated surpassing mean velocity riffle cross sections pool cross sections flows bankfull termed velocity reversals understand one mechanism riffle pool relief maintained study reenvisioned classic velocity reversal documenting stage dependent changes locations peak velocity without cross sections instead dynamics peak velocity patches considered flows spanning times bankfull discharge use high resolution dem two dimensional hydrodynamic modelling remarkable diversity peak velocity patch behaviour found across discharges including gradual expansion shifting well abrupt disappearance emergence relative low flow patch locations behaviours blended together varying degrees produce many reversals peak velocity across morphological units took substantially higher bankfull discharge peak velocities move riffles chutes fast glides pools discharges reversals occurred among morphological units significantly higher valley confined reach anastomosing reach copyright john wiley sons ltd
known objective psychopathy personality disorder characterized deficits personality behaviour personality deficits marked interpersonal affective facets including pathological lying grandiose sense self worth lack remorse callousness behavioural deficits defined lifestyle antisocial deficits including impulsivity parasitic lifestyle poor behavioural controls objective review provide clinicians appreciation clinical features psychopathy understanding structural functional derangements genetic environmental factors serve basis development psychopathy iii summary published reports pharmacological approaches management disorder methods literature search medline pubmed present conducted using mesh search terms psychopathy antisocial personality disorder alone combination subheading drug therapy additional databases included web science present international pharmaceutical abstracts present using text words psychopath antisocial personality searched search amazon books using search terms psychopathy sociopathy also performed bibliographies relevant articles searched additional citations data sources english considered inclusion background information broad subject headings searched review articles first human animal drug therapy articles evaluated giving preference papers using controlled trial methodology results discussion psychopathy personality disorder characterized lack conscience pathologic lying manipulative behaviour often superficial charm incidence psychopathy general population generally considered center dot higher proportion males females brain imaging studies psychopaths suggest smaller less active amygdala prefrontal cortex also appear physiological derangements psychopathy including alterations dysregulation neurotransmitter homeostasis dopamine serotonin altered endocrine responses testosterone cortisol altered autonomic responses emotional stimuli stressors although genetic environmental factors likely contribute developmental basis psychopathy factors poorly understood present date limited studies pharmacologic interventions psychopathy available insufficient trials determine efficacy new conclusion psychopathy serious personality disorder profound negative effects individuals society design rational therapeutic strategies disorder additional research needed discover specific pathological pathophysiological basis psychopathy elucidate genetic environmental factors responsible psychopathic development emerging evidence phenotypic variants psychopathy including successful unsuccessful types important clinicians cognizant psychopathic personality
study examined effects cognitive restructuring intervention program rational emotive behavior therapy irrational thoughts behaviors arising adverse childhood stress nigeria participants identified victims adverse childhood stress met criteria inclusion self report questionnaire treatment process guided adverse childhood stress management manual consists weeks full intervention weeks follow meetings study used repeated measures anova order see improvement participant across control treatment groups thoughts behaviors intervention program results show sex differences determine experience adverse childhood stress cognitive restructuring intervention program rational emotive behavior therapy irrational thoughts behaviors arising adverse childhood stress experience significantly reduced treatment group compared control group significant improvement also observed end intervention treatment group implication research practice discussed line outcomes finally study stressed importance follow study nigeria would assess irrational beliefs one measures ptsd symptoms emotional disturbance
patient male final diagnosis job syndrome hyper ige syndrome symptoms pruritus medication clinical procedure none specialty allergology objective rare disease background job syndrome hyper ige syndrome rare primary immunodeficiency disease annual approximate incidence less manuscript aims provide education regarding diagnosis management strategies syndrome worldwide case report year old boy seen clinic secondary persistent pruritus interfering sleep age months patient developed diffuse eczematous desquamating skin lesions subsequently diagnosed atopic dermatitis managed conservatively months years age intermittent exacerbations dermatitis persisted despite aggressive treatment regimen serum ige level increased exponentially period years peak value molecular genetic testing revealed dominant negative mutation within domain signal transducer activator transcription stat gene patient subsequently diagnosed job syndrome management included proper skin care prophylactic antibiotics immunomodulating agents psychotherapy conclusions job syndrome often unrecognized masquerade atopic dermatitis therefore genetic testing condition obtained patients treatment refractory additionally psychotherapy successful management strategy grating psychological impact imposed children excessive pruritus
continuing growth renewable penetration power systems becomes increasingly challenging manage operational uncertainty near real time stage via deterministic scheduling approaches paper explores necessity benefits implementability applying stochastic programming security constrained economic dispatch sced formulate stochastic look ahead economic dispatch laed model near real time power system operation concept uncertainty responses introduced assess power system economic risk respect net load uncertainties concept offers system operator simple yet effective gauge decide whether stochastic approach desirable deterministic one efficient stochastic dispatch algorithm innovative hybrid computing architecture proposed leverages progressive hedging algorithm shaped method numerical experiments conducted practical bus system illustrate effectiveness proposed approach
nutrient loadings nitrogen phosphorus aquatic environments increasing concern globally managing ecosystems drinking water supply food production often multiple sources nutrients landscape different hydrological flow patterns within stream river catchments considerable influence nutrient transport transformation retention processes eventually affect loadings vulnerable aquatic environments therefore order address options reduce nutrient loadings quantitative assessment effects real catchments need undertaken involves setting scenarios possible nutrient load reduction measures quantifying impacts via modelling recent two decades great increase use scenario based analyses strategies combat excessive nutrient loadings review published papers extracted web science applied models analyse scenarios agricultural impacts nutrients loadings catchment scale review shows scenario studies performed broad range climatic conditions large focus measures targeting land cover use land management reducing source load landscape studies considered manage flows nutrients changes landscape may used influence flows transformation processes studies considered spatially targeting measures landscape studies recent spatially differentiated options include land cover use modification application different land management options based catchments characteristics cropping conditions climatic conditions studies used existing catchment models swat inca choice models may also influenced setup scenarios use stakeholders designing scenarios communication results seem widespread practice would recommendable future scenario studies depth involvement stakeholders elaboration interpretation scenarios particular enhance relevance farm catchment management foster better policies incentives elsevier rights reserved
ethnic groups use music promote group favoritism values also enhance intergroup closeness understanding current study examined whether national music often used emphasizing intergroup separateness also reduce prejudice promote theory mind among two groups conflict jews arabs israel specifically study examined whether removing national song conflictual context introducing manner emphasizes group familiarity enhances mentalization positive attitudes groups arab jewish women randomly divided four groups exposed one two types national israeli songs holocaust day song hds associated israeliarab conflict memorial day song mds aired days remembrance israel fallen soldiers sung either jewish arab singer results demonstrated exposure hds enhanced theory mind sung arab singer moreover arabs heard hds demonstrated reduced prejudice jews compared mds results demonstrate national songs may epitome group favoritism used promoting theory mind even among adversarial groups
introduction patients mpn commonly present abnormalities laboratory coagulation tests consistent hypercoagulable state individuals mpn exhibit pattern exclusive bleeding thrombotic events many others bleeding thrombosis course disease aim study undertaken assess haemostatic defects platelet functions patients mpn materials methods one year prospective study conducted tertiary care centre north india department pathology collaboration department clinical haematology recently diagnosed cases mpn along age sex matched controls included patients antiplatelet drugs antimyeloproliferative treatment vitamin agonists antagonists ocps platelet count high grade fever liver disease pregnancy excluded study patients underwent screening investigations like cbc peripheral smear evaluation aptt protein measurement clot based assay aggregation studies adp optical aggregometry aggro link software chronolog aggregometer results present study cases included occult prothrombotic state suggested significantly reduced levels protein protein patient presented frank thrombosis patients haemorrhagic manifestations ranging subdural haematoma pin point petechial haemorrhages patients cml pmf mpn nos showed significantly reduced maximal aggregation adp compared control mpv also showed statistically significant increase patients conclusion thrombohaemorrhagic complications significantly affect morbidity mortality mpn patients assessed use platelet aggregation studies protein activities coagulation studies timely diagnosis prothrombotic haemorrhagic states decrease morbidity patients
vote ballot feature democratic society process decision making tending achieve philosophy democratic politics public eligible vote competent candidates leaders rapid development technologies network applications electronization actively promoted globally social transformation period concept electronic voting derived major advantages electronic voting comparing traditional voting lie mobility strength electronic voting reducing large amount election costs enhancing convenience public electronic voting allows voters completing voting internet climate location restrictions overcome voter turnout also increased voting time reduced public development past three decades electronic voting presents outstanding performance theoretically practically nevertheless regrettable electronic voting schemes still completely open lures money threats people lure money threats would confirm voters following instructions various methods factors would appear election results affecting quality fairness election study project aims design electronic voting scheme could actually defend voters free lure money threats would fail furthermore electronic voting system based elliptic curve cryptography proposed ensure efficiency security ring signature signcryption applied reducing computing costs moreover project also focuses applying voting system mobile devices system efficiency security emphasized voters need participate election simply complete voting smart phones ipads computers votes would automatically calculated verified results ballots necessarily printed printing election mails reduced manual handling canceled method would effectively reduce voting costs enhance economic efficiency
semantic web facilitates effective sharing reuse existing information institutional repositories irs built organize manage intellectual output institute generally use relational databases maintaining metadata digital documents focus research share information existing information systems discovering common interests process data semantic context relational database needs transformed ontology existing relation ontology transformation systems produces odd results applied database schema meta schema proposed system first creates intermediate database normalized schema data model institute preserved database transforms ontology finally semantic correspondence established entities source target ontologies order integrate system implemented evaluated correct lossless transformation results demonstrate transformation correct information preserved
present year old patient suffering frontotemporal dementia parkinsonism linked chromosome ftdp history included three generation pedigree patient found mutation carrier diagnosis hindered late appearance hypokinetic movement disorder clinicians important consider rare neurodegenerative disease variants early onset familial dementia syndromes behavioral cognitive motor symptoms
background based recent findings impressions took closer look relationship inter ictal photophobia psychometric variables migraine patients photophobia findings study included female migraine patients female controls mean age years years respectively participants filled depression anxiety stress scale dass interictal photophobia patients significantly higher photophobia controls patients showed statistically significantly higher levels depressive symptoms anxiety symptoms stress controls among participants interictal photophobia correlated positively age rho well levels depressive symptoms rho anxiety symptoms rho stress rho gender patients ictal photophobia correlated positively age rho interictal photophobia rho linear regression analysis revealed trend towards statistical significance interictal photophobia predictor level depressive symptoms rho whole sample conclusions considering higher levels photophobia depression comorbidity migraine depression might possible depression contributes interictal photophobia patients migraine may true anxiety stress also related migraine possible impact photophobia migraine may explained pupillary dysfunction
background strategy limited preoperative fasting carbohydrate cho loading intraoperative infusion omega polyunsaturated fatty acids omega pufa seldom tried cardiovascular surgery brief fasting followed cho intake anesthesia may improve recovery cabg procedures lower perioperative vasoactive drug requirements infusion omega pufa may reduce occurrences postoperative atrial fibrillation poaf shorten hospital stays aim study assess morbidity especially poaf icu patients coronary artery bypass grafting cabg cardiopulmonary bypass cpb combination preoperative fasts curtailed favor cho loading omega pufa infused intraoperatively methods fifty seven patients undergoing cabg randomly assigned receive maltodextrin anesthesia without infusing pufa cho water anesthesia without infusing pufa controls maltodextrin anesthesia plus intraoperative omega pufa mcg cho water anesthesia plus intraoperative omega pufa mcg perioperative clinical variables mortality analyzed examining incidence poaf well need inotropic vasoactive drugs surgery icu results two deaths occurred instances bronchoaspiration mediastinitis neither icu stays total postoperative stays differed group patients given preoperative cho loads cho cho groups experienced fewer instances hospital infection less reliant vasoactive amines surgery similarly number patients requiring vasoactive drugs recovering icu differed significantly group showing benefits patients given cho loads overall incidence poaf differing significantly group groups given pufa cho groups experienced significantly fewer instances poaf conclusion preoperative curtailment fasting safe cohort implemented conjunction cho loading infusion omega pufa surgery expedited recovery cabg cpb observed
introduction maternal obesity shown risk factor obesity children may also affect children psychosocial outcomes yet clear whether also psycho emotional mechanisms explaining effects maternal weight young children weight psychosocial development aimed evaluate whether maternal body mass index bmi mother child emotional availability maternal parenting stress associated children weight psychosocial development internalizing externalizing symptoms social competence whether predictors interact methods longitudinal study included three assessment points similar months apart baseline sample consisted mothers children aged months girls measured maternal weight height calculate maternal bmi videotaped mother child interactions coding scales fourth edition assessed maternal parenting stress parenting stress index psi short form measured height weight children calculated bmi sds scores children externalizing internalizing problems social competence assessed using questionnaires child behavior checklist cbcl strengths difficulties questionnaire sdq prosocial behavior checklist behavioral problems preschool age vbv social emotional competence results applying structural equation modeling sem latent regression analysis found maternal bmi predict higher bmi sds poorer psychosocial development higher externalizing symptoms lower social competence children higher parenting stress predicted higher levels externalizing internalizing symptoms lower social competence better maternal associated higher social competence found parenting stress serve mediator association maternal weight children psychosocial outcomes moreover children mothers elevated bmi greater risk lower social competence mothers showed low levels maternal moderation conclusion interventional studies needed investigate causal pathways parenting stress mother child interaction quality child outcomes aspects might targets improve psychosocial development offspring overweight obese mothers
objective executive function consists multiple cognitive processes operate interactive system produce volitional goaloriented behavior governed large part frontal microstructural physiological networks identification deficits executive function neurological psychiatric conditions difficult normal variation executive function test scores healthy adults multiple tests used largely unknown study addresses gap literature examining prevalence low scores brief battery executive function tests method sample consisted healthy individuals ages standardization sample delis kaplan executive function system kefs seven individual test scores trail making test color word interference test verbal fluency test analyzed results low test scores defined commonly used clinical cut offs percentiles occurred commonly among adult portion kefs normative sample sample one scores percentile one scores percentile prevalence low scores increased lower intelligence fewer years education conclusions multivariate base rates article allow clinicians understand normal frequency low scores general population use brs clinicians researchers improve accuracy identify executive dysfunction clinical groups traumatic brain injury neurodegenerative diseases
wireless sensor network wsn consists sensor nodes wireless communication sensor nodes usually features tiny size low cost low power consumption used environmental monitoring transmit sensing data temperature humidity pressure sink wireless networking protect sensing data confidentiality integrity presented intrusion detection system called patrol intrusion detection system pids designate fraction sensor nodes roaming patrol nodes detect malicious sensor nodes however patrol nodes battery energy consume rapidly thus makes whole wsn reduced lifetime paper system collect ambient data utilize revised artificial bee colony algorithm find low power consumption path transmitting attack feature packets pids order extend lifetime wsn
industry involvement ambient intelligence ami domain together openness complexity expected context aware applications drive research generic context management middle ware cmm solutions however variety ami scenarios requires flexibility design time run time deployment options existing cmm approaches sufficiently address means easily configure engineer mechanisms response challenges propose context management middleware design based techniques principles research fields multi agent systems semantic web focus showing deployment principles based directly application context model ontology based configuration options offered consert lead flexible development showcase usage solution scenario area smart university life management
half century ago dawn none learning era estes showed finite markov chains supply tractable comprehensive framework discrete change data sort envisioned shifts conditioning states stimulus sampling theory shortly thereafter data rapidly accumulated many spheres human learning animal conditioning estes work stimulated vigorous development markov models handle key outcome data workhorse paradigms episodic memory recognition recall proved one two stage markovian respectively close approximations subsequently markov modeling recognition recall disappeared literature reemerging wake dual process conceptions episodic memory recall particular markov models used measure two retrieval operations direct access reconstruction slave familiarity operation present paper develop family models present requisite machinery fit evaluation significance testing results reviewed selected experiments recall models used understand dual memory processes elsevier inc rights reserved
two types numerical errors occur implementation fast fourier transform fft coefficient errors arithmetic errors paper deals second type due finite word length used operations signal flow graph sub band dft dft fft realized efficient structure consists two parts hadamard part contains additions subtractions recombination part contains also multiplications outputs mathematical operations must scaled results two complement fixed point arithmetic errors classical radix cooley tukey type fft known various publications especially three radix dit butterflies defined studied normally used integrated dsp realizations differ quantizer locations three corresponding butterfly structures defined recombination network fft analysed theoretically error equations derived suitable error model real input data assumed analysis arithmetic errors fft rounding truncation scaling hadamard recombination parts monte carlo simulations included analysis arithmetic errors fft results thorough evaluation presented yielding insights mechanisms scaling multiplier output quantizations allowing comparison fft fft partial band versions fft arithmetic errors compared aliasing components inherent approximated versions half band quarter band fft considered study conclusions drawn necessary internal wordlengths fixed point realizations elsevier science rights reserved
synergistic effect displacement damage dose ddd analog transient radiation effects electronics atree operational amplifier opamp three different manufacturers investigated pulsed ray experiments highlighted atree sensitivity devices significantly important following exposure fission neutrons unirradiated devices previously developed simulation tool used model atree responses taking account electrical parameters degradation due displacement damage phenomenon good agreement observed model outputs experimental atree results
rabbits bacterial archaeal community caecal ecosystem composed mostly species yet described specific species mammals digestive ecosystem plays important physiological roles hydrolysis fermentation nutrients immune system regulation angiogenesis gut development acting barrier pathogens understanding functioning digestive ecosystem control functional specific diversity priority could provide new strategies improve resistance young rabbit digestive disorders improve feed efficiency review first recalls facts specificity rabbit digestive microbiota composition main fermentation compartment variability new insights based recent molecular approaches main functions digestive microbiota explained finally possible ways control rabbit caecal microbiota proposed suitable timing action defined
pediatric shoulder injury pathology disrupt muscle force balance resulting severe functional losses little data exists pertaining vivo pediatric shoulder muscle function musculoskeletal data crucially needed advance treatment pediatric shoulder pathology injury therefore purpose study develop pediatric database vivo volumes major shoulder muscles correlate volumes maximum isometric flexion extension internal external rotation abduction adduction joint moments methodology developed derive shoulder muscle volumes divide deltoid sub units unique torque producing capabilities based segmentation three dimensional magnetic resonance images eleven typically developing children adolescents years participated correlation regression analyses used evaluate relationship volume maximum voluntary isometric joint torques deltoid demonstrated largest supraspinatus smallest percent total summed volume six muscles evaluated anterior posterior deltoid sections total deltoid volume percent volumes highly consistent across subjects individual muscle volumes demonstrated moderate high correlations torque values study presents comprehensive database documenting normative pediatric shoulder muscle volume using data clear relationship shoulder volume torques produce established three rotational degrees freedom study furthers understanding shoulder muscle function serves foundation evaluating shoulder injury pathology pediatric adolescent population published elsevier ltd
paper introduces smart energy management system capable controlling energy smart home devices optimize power consumption several buildings individually smooth consumption peaks means central system proposed model consists two main systems energy storage units central energy management system first ones able store energy communicate devices transmit information regarding household consumption finally central system charge controlling energy storage units analyzing information provided data mining techniques deciding best operation strategy unit smooth load curves strategy consists set semantic rules based sequential patterns aim avoid peaks shutting low priority devices using properly energy stored
paper presents technique offline time synchronization data acquisition systems technique applied real time synchronization data acquisition systems impossible sufficiently accurate allows accurate synchronization based acquired dynamic response structure without requiring common response use trigger signal synchronization performed using results obtained system identification assumes linear dynamic behavior structure proportional damping structural modes demonstration laboratory experiment cantilever steel beam shows proposed methodology used accurate time synchronization resulting significant improvement accuracy identified mode shapes elsevier ltd rights reserved
background oral tolerance immune unresponsiveness induced oral administration innocuous antigens oral administration allergens shown effective suppressing ige production allergic responses however whether oral tolerance role protection allergic skin inflammation fully investigated evaluated potential protective role oral tolerance murine model atopic dermatitis investigated underlying immunologic mechanisms methods mice fed ovalbumin ova drinking water epicutaneously sensitized repeated application ova tape stripped skin skin biopsies analyzed immunohistopathologic features levels antibodies sera intestinal washes measured elisa flow cytometry real time pcr analysis skin mesenteric lymph nodes mln performed investigate immunologic effects oral tolerance epicutaneous sensitization induced allergic responses results induction oral tolerance effectively inhibited inflammatory responses provoked sensitization tolerogenic immune mediators significantly increased skin mln sensitized mice following induction oral tolerance marked increase expression infiltration eosinophils type innate lymphoid cells ilc skin sensitized mice significantly inhibited oral tolerance conclusions oral tolerance plays protective role development murine model modulating immune microenvironments favorable immune regulation modulation involves inhibition ilc infiltration skin lesions
seasonal affective disorder sad subtype major depressive bipolar disorders associated shortened photoperiod winter depressive disorder integrally tied seasonal regulation brain serotonergic system recently found cbl mice subjected forced swim test exhibited immobility photoperiod dependent depression associated behavior suppression brain serotonin levels however mice nocturnal animals unclear whether brain serotonergic system responds similarly photoperiod nocturnal diurnal species study compared responses brain serotonergic dopaminergic systems photoperiod diurnal chipmunks nocturnal cbl mice species serotonin levels dorsal raphe nuclei higher long day conditions short day conditions suggesting similarity photoperiod responses serotonergic systems however photoperiod affected dopamine levels various brain regions differently two species chipmunk brain regions exhibited stronger photoperiod induced changes dopamine levels cbl mice direction changes hypothalamus opposite conclusion photoperiod may regulate brain serotonergic system similar mechanisms regardless whether animals diurnal nocturnal photoperiod dependent regulation brain dopamine species specific elsevier ireland ltd rights reserved
study adolescent patients anorexia nervosa rated expected food anxiety response images portions food potatoes rice pizza showed lower energy dense foods elicited higher expected anxiety per kilocalorie higher energy dense foods however area portion sizes could unmeasured variable driving anxiety response test hypothesis area mediates effects energy content expected anxiety images portions measured area standardized values expected anxiety regressed standardized values energy area portions regression expected anxiety portion size area highest energy density four foods elicited highest expected anxiety slope beta significantly different expected anxiety slopes three foods beta range area confirmed mediator energy effects loss significance slopes area added regression expected anxiety energy food expected anxiety regressed food area energy area energy interaction area accounted times variance energy beta area significantly larger beta energy area could learned cue energy content food portions thus weight gain potential triggers anxiety patients anorexia nervosa crown copyright published elsevier ltd rights reserved
comparing time surfaces different integration time points different seeding areas provide valuable insight transport phenomena fluid flows comparative study challenging due often convoluted shapes surfaces propose new approach comparative flow visualization based time surfaces exploits idea embedding surfaces carefully designed reformed visualization space embedding enables new opportunities comparative flow visualization present three different strategies comparative flow visualization take advantage reformation reforming time surfaces mitigate occlusion issues devote also third dimension visualization space comparative aspects visualization approach effective variety flow study cases direct comparison individual time surfaces reveals small scale differences fine details fluid motion concurrent study multiple surface families enables identification comparison prominent motion patterns work developed close collaboration expert fluid dynamics assessed potential usefulness approach field
derived stimulus relations established stimulus functions altered present study aimed verify whether arbitrary symbols related meaningful stimuli facial expressions happiness would meaning transformed accordance relations sameness opposition experiment started training establish meaning two contextual cues one sameness one opposition using contextual cues one pair stimuli related opposite six photos containing different people expressing happiness stimulus set following training two stimuli related opposite respectively participants tested derived relations transformation functions happy pictures verified using semantic differential implicit relational assessment procedure irap results semantic differential happy sad scale taken together irap indicated transformation stimulus functions arbitrary stimuli acquired meaning similar opposite happy faces according trained derived relations sameness opposition
background individuals brain impairment less active general population increased risk chronic disease objective controlled trial evaluated efficacy physical activity intervention community dwelling adults methods total adults male female age years stage change walked primary means locomotion allocated intervention control condition intervention comprised face face home visits weeks including tailored combination stage matched behavior change activities exercise prescription community access facilitation relapse prevention strategies control group received face face visits weeks promote sun safety healthy sleep oral health primary outcomes daily activity counts minutes moderate vigorous intensity mvpa measured actigraph gtm baseline weeks postintervention weeks follow weeks group differences evaluated statistical significance using repeated measures anova results mvpa intervention group increased significantly baseline weeks min differences baseline weeks nonsignificant min mvpa changes control group negligible nonsignificant group differences change mvpa significant weeks weeks conclusion week intervention effectively increased adoption sample community dwelling adults immediately intervention follow future studies explore strategies foster maintenance participation
fatigue affects end stage kidney disease eskd patients significant repercussions quality life clinical outcomes fatigue management revolves around pharmacotherapy exercise modest short term improvements aim systematic review investigate whether social psychological interventions effective reducing fatigue eskd databases searched identify randomized controlled trials rcts quasi rcts determined effect social psychological interventions fatigue primary secondary outcome renal patient population meta analysis conducted sixteen rcts included predominantly among dialysis patients fatigue primary outcome two studies meta analytic findings showed significant improvement fatigue following social psychological interventions standardised mean difference smd evidence greater effectiveness interventions including stress management relaxation techniques evaluated among fatigued samples meeting diagnostic thresholds passive non active comparison groups studies generally poor quality high heterogeneity particularly number sessions ranging development evaluation fatigue specific social psychological intervention warranted setting
purpose aim study evaluate patient satisfaction scores interventional radiologists irs across united states using leading physician ratings website methods physician ratings website healthgrades manually queried medicare participating self designated irs patient reviewed irs primary likelihood recommending family friends field scored included resulting included irs physician characteristics extracted medicare data sets available patient satisfaction scores poor excellent likelihood recommend ease scheduling office environment staff friendliness trust physician decisions well physician explains condition well physician listens answers questions whether physician spends appropriate time patients wait times extracted healthgrades associations among measures explored results irs mean likelihood recommend score median received score received scores mean scores ranged office related factors physician related factors likelihood recommend scores showed substantial correlations office related factors physician related factors likelihood recommend significantly higher irs shorter wait times associated physician gender geographic region correlation physician age years since graduation group practice size conclusions satisfaction scores leading physician ratings website generally range good excellent irs patients leaving reviews likely recommend irs friends family members likelihood recommend strongly associated differences wait times
developing automatic weeding system requires robust detection exact location crop protected damage computer vision techniques effective means determining plant location paper novel algorithm based colour features morphological erosion dilation proposed process segments cauliflower crop regions image weeds soil natural illumination cloudy partially cloudy sunny proposed algorithm uses hsv colour space discriminating crop weeds soil region interest roi defined filtering hsv channels certain values minimum maximum threshold values region refined using morphological erosion dilation process moment method applied determine position mass distribution objects video sequences well track crops performance algorithm assessed comparing obtained results ground truth methods manual annotation sensitivity precision achieved elsevier rights reserved
adverse health effects smoking well known including effects musculoskeletal system limb reconstruction using external fixators high intensity process high levels patient contact time complications cost aim study examine smoking patterns group particular assess trends smoking cession data collected patients undergoing treatment using circular frame external fixation variety pathologies commonly acute tibial trauma patient reported questionnaire used data collected six month period population patients smokers study patients stopped smoking decreased smoking behaviour patients could recall given smoking cessation advice group patients unaware effects smoking bone healing made aware discussion proposed treatment stated part knowledge prompted positively change smoking habits results study show advice regarding smoking cessation limb reconstruction treatment potentially positive impact patients smoking habits effect smoking linked patient pathology discussed consent process taking time patient simple free intervention positive impact patient health potentially outcome current treatment opportunity missed elsevier ltd rights reserved
paper describes study undertaken determine influence variation cement content mechanical properties durability nano silica concrete series tests chloride diffusion tests conventional scanning electron microscopy sem techniques used study micro structural features concrete specimens contained nano particle percent weight cement furthermore compressive strength specimens also investigated cement content significant effect properties concrete cement content varied test specimens examined nano silica concrete mixture cement content respectively test results indicate difference manner nano specimen expected increasing cement content compressive strength nano specimens like water absorption increase optimal value chloride diffusion index reduces faster reference specimens sem observation shown nano silica particles make microstructure denser hand produces internal micro crack compare reference concrete although high pozolanic activity nano silica improves microstructure concrete speed hydration cause large pores area around anhydrate cement particles
address issue internal network security software defined network sdn technology introduced large scale cloud centers improves network performance also deals network attacks prevent man middle denial service attacks caused address resolution protocol bug sdn based cloud center study proposed bayes based algorithm calculate probability host attacker presented detection model based algorithm experiments conducted validate method
increasing demand personalization disease screening based assessment patient risk characteristics example breast cancer screening advanced imaging technologies made possible move away one size fits screening guidelines targeted risk based screening need diagnostic performance various imaging modalities may vary across subjects applying accurate modality patients would benefit requires personalized strategy address needs propose novel machine learning methods estimate personalized diagnostic rules medical screening diagnosis maximizing weighted combination sensitivity specificity across subgroups subjects first develop methods applied competing modalities screening strategies observed subject paired design next present methods studies subjects receive modalities unpaired design study theoretical properties including consistency risk bound personalized diagnostic rules conduct simulation studies examine performance proposed methods lastly analyze data collected brain imaging study parkinson disease using positron emission tomography diffusion tensor imaging paired unpaired designs results show cases personalized modality assignment estimated improve empirical area receiver operating curve compared one size fits assignment strategy copyright john wiley sons ltd
aims background systems training emotional predictability problem solving stepps group treatment individuals diagnosis borderline personality disorder bpd growing evidence base particularly evidence sparse use populations study seeks assess reliability evidence whilst adding existing knowledge use additional measures method thirty patients completed one four stepps groups data regarding symptom severity quality life affinity maladaptive schemas collected start end group allow pairwise analysis results significant reductions symptom severity affinity maladaptive schemas evidence well highly significant increases patients self reported quality life implications results provide evidence efficacy stepps sample patients diagnosis bpd though limitations design study warrant caution also show programme achieves level efficacy delivered facilitators intensively trained psychological treatment models stepps programme provides resourceful approach treatment bpd community based setting
epic earth polychromatic imaging camera channel spectroradiometer onboard dscovr deep space climate observatory spacecraft addition near infrared nir red channels epic also band band epic normalized difference vegetation index ndvi defined difference nir red channels normalized sum however use band instead red channel mitigates effect atmosphere remote sensing surface reflectance reduces contribution radiation scattered atmosphere applying radiative transfer theory spectral invariant approximation epic observations paper provides supportive arguments using band instead red channel monitoring vegetation dynamics results suggest use band enhances sensitivity top atmosphere ndvi presence vegetation published elsevier ltd
backgroundassessment implementation essential evaluation school based preventive activities interventions easily implemented schools detailed instructional manuals lesson plans materials provided however implementation may also affected factors intervention itselffor example school level characteristics principal support organizational capacity examined school level characteristics schools groups high medium low implementation smoking prevention intervention methodsthe study school randomized trial testing multicomponent intervention prevent smoking among adolescents data came electronic questionnaires completed school coordinators participating intervention schools first follow resultsschools implemented intervention medium high degree higher levels administrative leadership school climate organizational health mission policy alignment personnel expertise school culture positive classroom climate compared low implementation schools conclusionour findings highlight importance considering school context future health prevention initiatives
intronic ggggcc expansion corf common known cause frontotemporal lobar degeneration ftld amyotrophic lateral sclerosis als repeat expansion leads generation sense antisense repeat rna aggregates dipeptide repeat dpr proteins generated repeat associated non atg translation arginine rich dpr proteins poly glycine arginine poly proline arginine potently neurotoxic localise nucleolus expressed cells resulting enlarged nucleoli disrupted functionality furthermore ggggcc repeat rna bind nucleolar proteins vitro however relevance nucleolar stress unclear arginine rich dpr proteins localise nucleolus corf associated ftld als cftld als patient brain measured nucleolar size cftld frontal cortex neurons using three dimensional volumetric approach intriguingly found cftld brain exhibited bidirectional nucleolar stress cftld neuronal nucleoli significantly smaller control neuronal nucleoli however within cftld brains neurons containing poly inclusions significantly larger nucleolar volumes neurons without poly inclusions addition expression poly adult drosophila neurons led significantly enlarged nucleoli small significant increase nucleolar volume also observed cftld frontal cortex neurons containing ggggcc repeat containing rna foci data show nucleolar abnormalities consistent feature cftld brain diverse pathomechanisms play involving dpr protein repeat rna toxicity
introduction lesbian bisexual women higher body weight heterosexual women interventions focused health well versus weight loss may likely succeed among women article describes effects women health mindfulness week pilot intervention addressing mindfulness healthy eating physical activity outcomes associated chronic disease risk among overweight obese women older years method eighty women randomized using stepped wedge design either immediate delayed start intervention group delayed start group served control eligible participants aged years older identified body mass index greater compared differences biological markers chronic disease mindfulness nutrition physical activity immediate delayed start intervention groups results observed clinically significant improvements low density lipoprotein cholesterol change hemoglobin found evidence intervention effects improved mindfulness mindful eating scores nutrition improved vegetable intake conclusions women health mindfulness pilot intervention appears initiated positive behavioral physical health changes population refinements intervention model extended intervention duration longer term follow warranted determine sustained effects
using structural mri investigated brain substrates affective cognitive theory mind tom patients semantic dementia also ran intrinsic connectivity analyses identify networks substrates belong whether functionally disturbed semantic dementia line previous studies observed tom impairment patients semantic dementia even semantic memory regressed results also highlighted different neural bases according nature affective cognitive representations inferred affective tom deficit associated atrophy amygdala suggesting involvement emotion processing deficits impairment contrast cognitive tom performances correlated volume medial prefrontal parietal regions well right frontal operculum intrinsic connectivity analyses revealed decreased functional connectivity mainly midline cortical regions temporal regions also showed left medial temporal regions functionally isolated possible hindrance normal social cognitive functioning semantic dementia overall study addressed first time neuroanatomical substrates cognitive affective tom disruption semantic dementia highlighting disturbed connectivity within networks sustain abilities
practice teaching important part ideological political theory course colleges universities realization ideological political education purposes irreplaceable function meaning theory teaching however practice teaching education ideological political theory colleges universities however many problem notes allow ignore know team construction management guarantee mechanism four aspects strengthen strengthen ideological political theory class practice teaching effectiveness
paper presents systematic development unified signal flow graph model interleaved buck converter system operating continuous inductor current mode signal flow graph small large signal steady state models developed useful study converter dynamic steady state behaviour converter performance expressions like steady state voltage gain efficiency expressions small signal characteristic transfer functions derived development unified signal flow graph explained cell interleaved converter system derivation large small signal steady state models unified signal flow graph demonstrated considering cell interleaved buck converter system large signal model programmed tutsim simulator large signal responses supply load disturbances predicted signal flow graph analysis results validated psim simulations mathematical models obtained signal flow graph modelling agreement obtained state space averaging technique copyright john wiley sons ltd
axial spa axspa chronic inflammatory condition predominantly involving spine sacroiliac joints sij without extra spinal manifestations including peripheral arthritis enthesitis iritis psoriasis ibd individuals axspa experience significant pain stiffness lack function translates important health care costs increased mortality axspa classified two subgroups radiographic axspa commonly referred nonradiographic axspa axspa primary difference two subgroups presence absence defined structural changes sij detected plain radiography although patients axspa fulfil modified new york criteria burden disease similar may derive much benefit treatment patients established revision bsr guidelines provides evidence based guidance clinicians prescribing biologic drugs adult patients across spectrum axspa includes criteria starting treatment choice drug assessing response treatment peripheral spondyloarthritis juvenile spa outside scope guidelines readers referred bsr guidelines management psa
background collaborative assessment management suicidality cams therapeutic framework appears promising reduce suicidal ideation suicidal cognition cams previously evaluated standard specialized mental health care setting patients suicidal problems general pragmatic randomized controlled trial rct investigate cams effective treatment usual tau reducing suicidal thoughts behaviors effects also investigated mental health symptom relief general upon readmissions inpatient units methods design study multicenter observer blinded superiority two armed rct include patients four clinical departments vestre viken hospital trust norway aim include patients moderate strong suicidal problems defined score beck scale suicide ideation current patients included regardless diagnosis randomization performed using stratified four block procedure treatment unit stratification variable duration treatment vary depending patients needs clinical assessments patients interviewed research staff four checkpoints baseline weeks months months central outcome measures beck scale suicide ideation current outcome questionnaire suicide attempt self injury count discussion pragmatic trial effectuated within public health care system norway patients multiple problems diagnoses therapists high work load results trial highly generalizable typical everyday clinical setting one expect similar results cams implemented future standard component specialized mental health care systems
purpose systematically reviewed preclinical clinical studies bladder chemodenervation onabotulinumtoxin highlight current limitations future drug delivery approaches materials methods identified peer reviewed basic clinical research studies onabotulinumtoxin treatment neurogenic bladder refractory idiopathic overactive bladder published march march paired investigators independently screened english language articles identify controlled studies onabotulinumtoxin administration medline database abstracts presented annual american urological association meetings review yielded evidence base articles relevant approach injection free onabotulinumtoxin chemodenervation results efficacy safety intradetrusor injection onabotulinumtoxin treatment overactive bladder sensitive injection volume depth issue motivated researchers study injection free modes drug delivery bladder urothelial denudation protamine sulfate dimethyl sulfoxide liposome encapsulated onabotulinumtoxin physical approaches studied increase toxin permeability avoid intradetrusor injections liposome encapsulated onabotulinumtoxin enhances toxin activity reducing toxin degradation safety efficacy liposome encapsulated onabotulinumtoxin tested multicenter placebo controlled study although treatment successfully reduced urinary frequency urgency significantly reduce urgency urinary incontinence episodes conclusions intradetrusor injection onabotulinumtoxin safe effective treatment reported several large multicenter randomized controlled trials injection toxin bladder wall impairs afferent efferent nerves injection free drug delivery approaches impair bladder afferent nerves studies needed develop better drug delivery platforms overcome drawbacks intradetrusor injection increase patient acceptance reduce treatment costs
patients major depressive disorder bipolar disorder abnormalities excitatory inhibitory neurotransmission neuronal plasticity may lead aberrant functional connectivity patterns within large brain networks network dysfunction association altered brain levels glutamate gamma aminobutyric acid identified animal human studies depression addition evidence antidepressant response subanesthetic dose ketamine led collection studies examined neurochemical glutamatergic gamma aminobutyric acidergic functional imaging correlates associated effect results studies suggest antidepressant response association ketamine occurs part reversing neurochemical physiological disturbances future studies depression require combination neuroimaging approaches biologically homogeneous subgroups identified particularly respect treatment response biomarkers glutamatergic modulation
despite gradual adoption technology rail industry automatic warning systems aws train driving still remains relatively complex form human performance paper examine key contextual psychological factors influence train driving performance driving related incidents argue goal conflicts time running safe train management contribute poor driving performance increased risk incidents disinhibited drivers drawing well established model disinhibition namely response modulation model patterson newman explain impulsive behavior negative emotions arise individuals high threat sensitivity low working memory facing approach avoidance conflict form goal conflict disinhibited train drivers propose difficulty switching attention competing tasks contributes poor driving performance increased risk incidents also present results experimental study involving experienced train drivers provides evidence support proposition finally believe methods measures used study could eventually improve way train drivers selected trained elsevier ltd rights reserved
flow experience widely investigated experiential activities sports performing arts gaming internet usage studies focus positive aspects flow experience effect performance stark contrast gambling research focusing negative side addiction lacks depth investigation gamblers positive flow encounters separation research lines seems place given recent research indicates connections flow addiction joining constructs causal effects model helps one gain better understanding relationship contingencies article empirically investigates whether possible observe janus face flow various sub dimensions online gambling empirical data collected online gamblers applying structured questionnaire established scales data analyzed confirmatory factor analysis double hurdle model separate casual gamblers unsusceptible addiction issues gamblers affected initiatory addiction issues findings indicate online gambling addiction negatively influenced two sub dimensions flow experience namely sense control concentration task hand whereas enhanced transformation time autotelic experience
present simple geometric framework relational join using framework design algorithm achieves fractional hypertree width bound generalizes classical recent worst case algorithmic results computing joins addition use framework algorithm show series colloquially known beyond worst case results framework allows prove results data stored btrees multidimensional data structures even multiple indices per table key idea framework formalizing inference one index type geometric resolution transforming algorithmic problem computing joins geometric problem notion geometric resolution viewed geometric analog logical resolution addition geometry logic connections algorithm also thought backtracking search memoization
background data capture clinical registries pilot studies often performed spreadsheet based applications like microsoft excel ibm spss usually data transferred statistic software sas ibm spss statistics analyses afterwards spreadsheet based solutions suffer several drawbacks generally possible ensure sufficient right role management traced changed data therefore systems able comply regulatory requirements electronic data capture clinical trials contrast electronic data capture edc software enables reliable secure auditable collection data regard edc vendors support cdisc odm standard define communicate archive clinical trial meta patient data advantages edc systems support multi user multicenter clinical trials well auditable data migration spreadsheet based data collection edc systems labor intensive time consuming present hence objectives research work develop mapping model implement converter ibm spss cdisc odm standard evaluate approach regarding syntactic semantic correctness results mapping model ibm spss cdisc odm data structures developed spss variables patient values mapped converted odm statistical display attributes spss corresponding odm elements study related odm elements available spss converting tool implemented command line tool using spss internal java plugin syntactic semantic correctness validated different odm tools reverse transformation odm spss format clinical data values also successfully transformed odm structure conclusion transformation spreadsheet format ibm spss odm standard definition exchange trial data feasible facilitates migration excel spss based data collections towards reliable edc systems thereby advantages edc systems like reliable software architecture secure traceable data collection particularly compliance regulatory requirements achievable
witnessed tremendous momentum second spring parallel computing recent years remember low points field years ago review lesson led question point whether parallel computing soon relegated trash heap reserved promising technologies never quite make article entitled death parallel computing written late ken kennedy prominent leader parallel computing world facing new era parallel computing learn robust history sequential computation past years study foundation established model turing machine profound impact history end paper examines disappointing state work parallel turing machine models past years parallel computing research lacking solid yet intuitive parallel turing machine model continue serious challenge future parallel computing paper presents attempt address challenge presenting proposal parallel turing machine model also discuss start work paper parallel turing machine model instead choices
virtual power plant vpp concept developed integrate distributed energy resources ders grid order seen single power plant market power system operator therefore vpps faced optimal bidding identifying arbitrage opportunities market environment study authors present arbitrage strategy vpps participating energy ancillary service spinning reserve reactive power services markets basis security constrained price based unit commitment proposed model maximises vpp profit revenue minus costs considering arbitrage opportunities supply demand balancing transmission network topology security constraints considered ensure reliable operation vpp mathematical model mixed integer non linear optimisation problem inter temporal constraints solved mixed integer non linear programming result single optimal bidding profile schedule managing active reactive power participating markets profile schedule consider ders network constraints simultaneously explore arbitrage opportunities vpp results pertaining illustrative example case study discussed
children eating behaviour questionnaire cebq developed measure eating behaviors related obesity risk children however questionnaire validated use south east asia parenting practices different western countries child obesity rates increasing aim study examine validity cebq administered mothers children aged years singapore confirmatory factor analysis cfa used examine original item factor model supported cohort participants mother child dyads mean child age months growing singapore towards healthy outcomes gusto birth cohort mothers characterized pregnancy children followed age years cfa showed poor model fit rmsea pclose enjoyment food food fussiness emotional overeating desire drink emotional eating satiety responsiveness slowness eating cronbach alpha estimates ranged subscales convergent validity tests via correlation analysis revealed emotional eating slowness eating satiety responsiveness negatively correlated bmi score years enjoyment food positively correlated conclusion found revised factor structure cebq appropriate examining eating behavior year old children singapore setting replication studies separate cohort study warranted use factor structures generated elsevier ltd rights reserved
parkinson disease aging associated neurodegenerative disease characteristic feature alpha synuclein accumulation point mutations increase aggregation propensity alpha synuclein result familial early onset abnormal metabolism alpha synuclein results aberrant level changes alpha synuclein pathological conditions alpha synuclein degraded mainly autophagy lysosome pathway triptolide monomeric compound isolated traditional chinese herb group demonstrated first time possesses potent neuroprotective properties vitro vivo models present study reported potent autophagy inducer neuronal cells helped promote clearance various forms alpha synuclein neuronal cells transfected neuronal cells mutant wild type alpha synuclein plasmids found attenuated cytotoxicity induced pathogenic alpha synuclein overexpression observed significantly reduced alpha synuclein level neuronal cell line well primary cultured cortical neurons excluding changes syntheses secretion aggregation alpha synuclein added autophagy inhibitor proteasome inhibitor noticed promoted clearance alpha synuclein mainly autophagic pathway lastly observed increased autophagy marker expression autophagosomes gfp accumulation ultrastructural characterization however lysosome activity cell viability modulated study revealed could induce autophagy promote clearance alpha synuclein neurons results provide evidence promising mean treat neurodegenerative diseases reducing pathogenic proteins neurons
oriental medicine samhwangsasim tang shsst traditionally used east asia treat hypertension complications however little known potential value regarding treatment chronic inflammatory diseases multiple sclerosis study investigated whether shsst beneficial effect treating myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis eae onset treatment shsst found alleviate neurological symptoms well demyelination glial activation spinal cords eae mice shsst also attenuated mrna protein expression pro inflammatory cytokines interleukin beta tumor necrotic factor alpha chemokines rantes monocyte chemotactic protein macrophage inflammatory protein alpha inducible nitric oxide synthase cyclooxygenase correspondence regulation nuclear factor kappa mitogen activated protein kinases signal pathways spinal cords eae mice interestingly protective effect shsst related decreased number cells increased number treg cells spinal cords eae mice taken together finding firstly suggested shsst could delay mitigate eae wide therapeutic time window suppressing cell responses upregulating treg cell responses also findings strong enough warrant investigation shsst treatment chronic autoimmune diseases including
accumulation amyloid beta beta peptides brain alzheimer disease patients associated cognitive deficit increased oxidative stress alterations circadian rhythms brain derived neurotrophic factor bdnf neurogranin play important role synaptic plasticity underlying memory learning previously observed bdnf expression follow daily rhythmic pattern hippocampus young rats objective study investigate effects intracerebroventricular injection aggregated peptide temporal patterns apoe protein bdnf mrna lipid peroxidation lpo reduced glutathione gsh levels rat hippocampus observed injection aggregates phase shifts daily bdnf expression well lpo decreased mesor gsh rhythms apoe protein levels vary rhythmically throughout day apoe levels increase hippocampus control rats treated animals thus elevated levels beta aggregates characteristic altered temporal patterns cognition related factors probably consequence changes daily variation apoe mediated aggregates clearance well rhythms cellular redox state elsevier rights reserved
study aims analyze users form interaction problems terms interface design considering people constant interaction mobile devices important place daily life purpose location interface design elements changes caused development process mobile communication technology addressed directly associated topics required literature reviews done descriptions opinions related interface design given place addition notion usability interface usability user oriented interface design importance interface human computer interaction tried explained due widely used operating systems android ios interface design operating systems analyzed considering basic graphic design principles order measure usability interfaces one interrogation methods based information collected focus groups end study results design analysis participants compared situation evaluation done
nanomaterials hold significant potential industrial biomedical application years therefore relationship nanoparticles neurodegenerative disease enormous interest contribution zebrafish embryos cell lines selected studying neurotoxicity titanium dioxide nanoparticles tio nps exposure different concentrations tio nps embryos fertilization hpf hatching time zebrafish decreased accompanied increase malformation rate however significant increases mortality relative control observed results indicated tio nps exposure hold risk premature zebrafish embryos fatal investigation confirmed tio nps could accumulate brain zebrafish larvae resulting reactive oxygen species ros generation cell death hypothalamus meanwhile pcr analysis showed tio nps exposure increased pink parkin alpha syn uchl gene expression related formation lewy bodies also observed loss dopaminergic neurons zebrafish vitro remarkable hallmarks linked parkinson disease symptoms results indicate tio nps exposure induces neurotoxicity vivo vitro poses significant risk factor development
study following questions related wireless network security jammer placement configuration jamming attack results largest degradation network throughput network design strategies effective mitigating jamming attack although others studied similar jammer placement problems article first optimize network throughput subject radio wave interference formulate problem level mixed integer program solve using cutting plane approach able solve networks transmitters typical size studies wireless network optimization experiments algorithm also yielded following insights wireless network jamming increasing number channels best strategy designing network robust jamming attacks increasing range jammer best strategy attacker wiley periodicals inc networks vol
nowadays although throughout europe catholic orthodox muslim protestant denominational identities remain among roma conversion rate would suggest number roma pentecostal numerically overtaken others years time uniqueness spanish gypsy pentecostalism contradicts stereotypes global pentecostalism resides organisational complexity hierarchical structure rapid institutionalisation sole church thorough theological training leaders autonomy state european latin american pentecostal roma movement article structured around life history two concerns role constant circulation gypsy evangelical ministers regards charisma leadership growing transfer prestige respected gypsy elders young evangelical pastors role wide pacification processes involving ethnic cohesion kinship
article deals nature characteristics use benchmarking automobile industry domestic enterprises activity current economic conditions article identifies concept benchmarking examining stages determinates efficiency benchmarking workautomakers determines economic aspects benchmarking work automobile industry enterprise stages innovative products benchmarking modern conditions productive forces development market factors analysed market electric vehicles studied ukraine authors improved methodical approach assess vehicles selection best technical parameters based benchmarking unlike existing ones based calculation vehicles technical specifications integral factor order establish better competitive product automobile industry companies among evaluated aspects need taken account cjsc zaporizhia automobile building plant management improve competitiveness electric vehicles identified benchmarking regarded one important area marketing strategic research enterprises automotive industry must develop activities study best products marketing process proposed compared enterprises competitors prospects study related methodological approaches formation identify market segments cars electric motor depending price quality technical characteristics
research indicates inducing high level construal processing highlights invariant essential features relative low level construal processing highlights idiosyncratic peripheral features promotes self control fujita carnevale present work investigate extent people recognize self control benefits high level construal explore consequences knowledge studies provide initial evidence individuals aware high level relative low level construal promotes self control dieting domain studies find individual differences knowledge predict self control success outcomes body mass index among motivated dieting goals examining academics domain self control study demonstrates higher knowledge construal level impact self control earned higher end semester grades extent motivated well academically theoretical practical implications findings discussed
cellulose reported renewable smart material useful sensors actuators report enhanced electromechanical behavior zinc oxide nanocoated cellulose film zonce zinc oxide nanolayer uniformly formed surface regenerated cellulose film using solution based hydrothermal process simple zno nanolayer deposition zonce shows drastic improvement electromechanical behavior physical chemical electrical mechanical electromechanical characteristics along reasons improved electromechanical behavior zonce discussed paper using zonce vibration energy harvester demonstrated promising zonce easy fabricate inexpensive solution process without sacrificing biocompatibility transparency flexibility low cost acta materialia inc published elsevier ltd rights reserved
background aims despite advances knowledge effective services people use drugs last decades globally coverage remains poor countries quality often unknown paper aims discuss historical development successful epidemiological indicators present framework extending additional indicators coverage quality harm reduction services monitoring evaluation international national subnational levels ultimate aim improve services order reduce health social problems among people use drugs human immunodeficiency virus hiv hepatitis virus hcv infection crime legal problems overdose death morbidity mortality methods results framework developed collaboratively using consensus methods involving nominal group meetings review existing quality standards repeated email commenting rounds qualitative analysis opinions experiences broad range professionals experts including members civil society organisations representing people use drugs twelve priority candidate indicators proposed opioid agonist therapy oat needle syringe programmes nsp generic cross cutting aspects harm reduction potentially drug services specific oat indicators priority indicators included coverage waiting list time dosage availability prisons specific nsp indicators priority indicators included coverage number needles syringes distributed collected provision drug use paraphernalia availability prisons among generic cross cutting indicators priority indicators infectious diseases counselling care take away naloxone information safe use sex condoms discuss conditions successful development suggested indicators constraints funding ideology propose conducting pilot study test feasibility applicability proposed indicators scaling routine implementation evaluate effectiveness comparing service coverage quality across countries conclusions establishment improved set validated internationally agreed upon best practice indicators monitoring harm reduction service provide structural basis public health epidemiological studies support evidence human rights based health policies services interventions
objective systematically determine prevalence diabetes mellitus impaired fasting glucose ifg impaired glucose tolerance igt psychiatric inpatients explore impact patient study variables prevalence estimates method searched embase psychinfo medline central database inception december included studies design reporting prevalence abnormal glucosemetabolismin adult psychiatric inpatients conducted random effectsmeta analysis generate pooled prevalence estimates chisquare tests compared differences within categorical variables inpatient setting continent study patient diagnostic category spearman correlation analyses assessed impact linear variables age year data collection study quality study quality assessed using adapted newcastle ottawa scale results study reports representing unique cohorts included across studies prevalence unspecified type tdm tdmwas ifg igt estimates affected study quality conclusions estimates higher compared general population mental health professionals aware elevated prevalence improve screening management abnormal glucose metabolism elsevier inc rights reserved
business manufacturing companies evolving towards knowledge intensive industrial services important stay near customer process possible evolution enable growth efficiency customer business life cycle type business addition managing material financial flows information knowledge flows managed much better however complexity also increasing new offerings need network operations manage distributed information competence obvious business model supporting business structures partners value network constant transition thus important master innovation customer process life cycle objective article introduce concept integrated service product development various types innovation life cycle business evolution routing business changing various types innovations tackle business market life cycle innovation knowledge intensive service innovation needs open semantic infrastructure master data structures provided life cycle management architecture balance running business comes synergy management hybrid innovation model developed joint initiative research institute experts various international companies applied individual enterprise strategies order validate synergy management hybrid innovation used drive business value creation new services insight one participant case study provided substantiate breadth applicability ease use
background mental rehearsal form mental training used physicians nurses improve performance clinical skills vital component stress management training help novice nurses deal often stressful clinical events require processing information essential patient management mental rehearsal strategy developed implemented year nursing simulation program inherent mental rehearsal imagery facilitates cognitive affective modification reduction extraneous cognitive load expected mental rehearsal strategy would improve students performance reduce stress managing deteriorating patients methods study used mixed methods design eighteen year nursing students participated pre post design study consisted development implementation mental rehearsal strategy rescuing patient deteriorating situations rapids tool used assess performance heart rates systolic blood pressures used measure stress state trait anxiety inventory stai used psychological measure stress anxiety five participants involved focus group discussion evaluated usefulness mental rehearsal strategy results significant improvement performance however post test heart rate systolic blood pressure significantly different pre test measures comparison stai results show significant differences pre post test state anxiety pre post test trait anxiety three themes emerged focus group interview managing stress using mental framework integrating realistic simulations mental rehearsal strategy conclusion mental rehearsal strategy deteriorating patient management valuable based findings performance based participants feedback role reducing stress however needs evaluation elsevier ltd rights reserved
despite marked progress past several decades convective storm nowcasting remains challenge nowcasting systems based linear extrapolation radar reflectivity without much consideration meteorological fields variational doppler radar analysis system vdras advanced convective scale analysis system capable providing analysis wind temperature humidity assimilating doppler radar observations although potentially useful still open question use fields improve nowcasting study present results first attempt developing support vector machine svm box based nowcasting sbow method machine learning framework using vdras analysis data key design points sbow follows study domain divided many position fixed small boxes nowcasting problem transformed one question radar echo dbz appear box min box based temporal spatial features include time trends surrounding environmental information constructed box based constructed features used first train svm classifier trained classifier used make predictions compared complicated expensive expert systems design sbow allows system small compact straightforward easy maintain expand low cost experimental results show although complicated tracking algorithm used sbow predict storm movement trend storm growth reasonable skill
background injury devastating setback elite athletes whereby injury prevention plays key role biography athletes study three aims compare differences german taiwan elite athletes injury related factors evaluate influence factors injury frequency identify possible interactions within injury related factors injury risk cohorts methods total elite athletes taiwanese athletes mean age german athletes mean age participated inclusion criterion current retired national team members olympic sports risk injury questionnaire risk elite athletes used scores calculated individual scales subscales analysis descriptive statistics independent sample tests spearman correlation mann whitney test kruskal wallis anova tests employed generalized linear models multivariate regression scales subscales used significance set results hypothesis results medical care environment training stress injury caused losses factors tested significantly different german taiwanese cohorts hypothesis regardless nationality injury contributing factors age sport types experience levels medical care cardiovascular problem training stress hypothesis interaction effect existed sport type format injury caused losses medical care conclusions injury related influencing factors interactions found via multi disciplines integrated risk regardless heterogeneous recruitment top injury risk factors experience level international competition number periodic health examination pre participation evaluation received sport types stress life events age
paper presents three phase harmonic sequence components measurement method based modulated sliding discrete fourier transform msdft variable sampling period technique proposal allows measuring harmonic components three phase signal computes corresponding imbalance estimating instantaneous symmetrical components addition adaptive variable sampling period used obtain sampling frequency multiple main frequency dft typical errors known spectral leakage picket fence effect mitigated steady state proposal tested different disturbances simulation experimental results results obtained power quality monitor implemented proposed system also presented high rejection distortion electrical network frequency adaptability flexibility good performance power quality monitor application render proposed method promising alternative signal processing mains
changes character industrial production happened last decades required make significant adjustments training engineers training engineers almost specialties directions higher education last century development production largely depended improvement technological modes machine design introduction new process control techniques necessary pay much attention study well known given technologies detailed knowledge particular technology essential success engineer recent years situation comletely changed main direction industrial production development introduction modern technologies states new demands engineers important ability learn develop new technologies processes forced reconsider content engineers training circumstances mendeleev university muctr mission meet growing needs economy civil society russia train competitive specialists able work chemical industry high tech sectors country production research educational sectors considering extensive experience years leading chemical technological university country university seeks apply accumulated potential development innovative approaches training competent engineering scientific managerial personnel wide range sectors activity aimed modernizing country economy main competitive advantages muctr existence famous scientific educational schools university successfully operate even low resource support widespread introduction new educational standards training retraining programs existence successfully working system integration university academic science industry current system selection talented students active involvement young teachers researchers higher education real mechanism rapid response needs economy training engineers highly qualified scientific personnel guaranteed employer demand specialists bachelors masters chemical petrochemical innovative industries awareness management scientific educational community mendeleev university responsibility targeted training efficient use scientific technical elite strategic objectives modernization russian economy
background vitamin deficiency recognized major public health nutrition issue developing countries limited hospital sources sample sizes available existing studies associated healthy school age children aim study compare vitamin status year old healthy children china methods according china national nutrition health survey chnns chnns choose year old children research object measure serum retinol concentrations children using high performance liquid chromatography hplc children divided two groups year old year old areas divided urban rural area results total number children year old survey survey vitamin level children higher level vitamin year old group higher year old group across areas genders difference incidence vitamin deficiency children incidence vitamin deficiency urban children higher incidence vitamin deficiency year old group lower year old group across areas genders incidence marginal vitamin deficiency children lower similar phenomena also found across area groups incidence marginal vitamin deficiency year old group lower year old group across areas genders difference vitamin status children across area gender age groups conclusion vitamin nutritional status children significantly improved compared however vitamin deficiency still moderate public health problem chinese children especially younger school age children consequently controlling incidence vitamin deficiency imperative promoting chinese children health
paper solution series multiple fan systems control presented applicability modern building mine ventilation systems obvious order validate proposed solution experimental stand real time software developed control algorithm based three multiple models system configurations one consisting three operating systems specific experimental stand
background effective communication increasingly recognised core clinical skill many health social care professionals however feel adequately trained communicating handling interpersonal issues arise care patients cancer aim aim paper assess effectiveness different training methods used communication training courses health professionals method searched six computerised databases augmented follow references grey unpublished literature included studies evaluating communication training assessed methodological quality according standard grading system clinical outcomes group data author year setting objectives study design training methods extracted compared tabular format results total studies potentially assessing communication training identified sixteen papers included evaluating interventions four randomised controlled trials rcts grade others grade iii eleven interventions trained health professionals two trained medical students interventions training communication skills characterised variety communication approaches used diversity methods applied health professionals different roles served different purposes evaluated variety outcome measures behavioural assessments patient outcomes professionals self report conclusions best results expected training programme carried longer period time learner centred programmes using several methods combining didactic component focusing theoretical knowledge practical rehearsal constructive feedback peers skilled facilitators proved effective small groups encouraged intensive participation training communication medical nursing students senior health professionals advisable
bringing quantum science technology space frontier offers exciting prospects fundamental physics applications long range secure communication space borne quantum probes inertial sensing enhanced accuracy sensitivity despite important terrestrial pathfinding precursors common microgravity platforms promising proposals exploit significant advantages space quantum missions large scale quantum test beds space yet realised due high costs lead times traditional big space satellite development small space revolution spearheaded rise nanosatellites cubesats opportunity greatly accelerate progress quantum space missions providing easy affordable access space encouraging agile development review space quantum science technology cubesats rapidly developing capabilities used advance quantum satellite systems
despite high activity photocatalytic degradation organic dyes water nanoscale agpo photocatalyst particles difficult synthesize reported literature agpo particle sizes photocatalytic degradation water pollutants normally larger research reports facile reproducible method synthesis ultrafine uniform agpo nanoparticles loaded oxygen vacated tio tio average particle size small obtained agpo particles completely loaded onto tio support form agpo tio composite photo catalysts prepared agpo tio photocatalyst exhibits much higher visible light photocatalytic activity pure agpo agpo tio photocatalysts degradation rhodamine phenol water depositing thin layers agl agpo ultrafine agpo nanoparticles new agi agpo tio composite photocatalysts show much higher photocatalytic activity also stable pure agpo catalyst new synthesis method provide guidelines preparation ultrafine nanoparticles highly active photocatalysts treatment water pollution production hydrogen water splitting reducing elsevier rights reserved
study objectives sleeping hours per night appears optimal since shorter longer sleep times related increased morbidity mortality depressive disorder almost invariably accompanied disturbed sleep leading decreased sleep duration disturbed sleep may precipitating factor initiation depressive illness examined whether healthy individuals sleep duration associated genes earlier found associated depressive disorder design population based molecular genetic study setting regression analysis risk variants depressive disorder genes sleep duration healthy individuals participants three thousand one hundred forty seven individuals population based health finrisk samples measurements results found significant association gria chromosome sleep duration women permutation based corrected empirical beta bonferroni corrected frequency genotype previously found increase risk depression women highest among slept hours less age groups younger years frequency decreased lengthening sleep duration slept hours showed higher frequency genotypes compared midrange sleepers hours permutation based corrected empirical conclusions gria polymorphism previously found associated depressive disorder women showed association sleep duration healthy women mood disorders short sleep may share common genetic background biologic mechanisms involve glutamatergic neurotransmission
objectives study aims describe dietary status turkish adults using two different versions healthy eating index hei methods cross sectional study healthy participants females randomly selected living ankara included september march questionnaire completed anthropometric measurements weight height performed dietary recall individuals collected diet quality measured hei hei scores results mean age body mass index bmi hei hei scores individuals years points respectively significant differences found mean hei hei scores individual whose diet quality needs improved according mean hei score poorer diet based mean hei scores highest mean hei hei scores stated female subjects low education levels aged years older overweight groups versions healthy eating indices correlated positively bmi age conclusion diet qualities individuals associated age gender education bmi although components scores hei version changed version hei changes may encourage healthy choices food group hei gives attention food quality hei thus present study concluded hei provided precise results diet quality
liquid marbles drops coated hydrophobic powder different liquid marbles easily distinguished diverse color appearance first demonstrate colorful liquid marbles encapsulated colored superhydrophobic stearate powders simple method used generate colorful superhydrophobic stearate powders via chemical reactions sodium stearate inorganic salts addition contact angle meter used monitor horizontal profiles liquid marbles investigate lifetime liquid marbles stainless steel surface room conditions important described proof qualitative detection oil pollution measured minimum detection limit water soluble pollutants liquid marbles
debate personal persistence characterized dichotomy due still cartesian framwork one side find proponents psychological continuity connect locke tradition persistence person constancy first person perspective retrospection side proponents biological approach take diachronic identity consist continuity organism carrier personal existence third person perspective thus accounts someone persistence time continuity mind one hand continuity body contrast views paper intends show bodily existence represents basis selfhood across time continuity experiential self continuity autopoietic organism one hand lived body conveys continuity self first person perspective namely pre reflective feeling sameness felt constancy subjectivity moreover analysis awakening sleep shows continuous transition full wakefulness periods deep sleep may thus regarded complete interruption subjective experience hand constancy converges continuity organismic life process conceived third person perspective thus experiential self bodily subjectivity autopoietic self living organism regarded two aspects one life process finally lived body also exhibits specific form memory results continual embodiment existence consists affinities capacities experiences person acquired throughout life thus provides continuity self must actively produced remembering rather integrates person entire past present potentiality
levels circulating cytokines elevated inflammatory diseases previously shown interleukin synergism dihydroxyvitamin tumor necrosis factor tnf alpha induces release granulocyte macrophage colony stimulating factor csf murine osteoblasts vitro study analyzed effects csf osteoclast development vitro effects tnf alpha regulation osteoclast development investigated cocultures bone marrow derived osteoclast progenitor cells opc mouse calvarial osteoblasts additionally opc grown days media containing macrophage colony stimulating factor csf csf csf csf subsequently osteoclastogenic potential capacity dissolve amorphous calcium phosphate assessed three populations opc synergism tnf alpha inhibited development osteoclasts cocultures stimulating osteoblast lineage cells release csf csf treated opc expressed traits characteristic dendritic cells upon removal csf supplementation culture media csf rank cells lost dendritic cell characteristics differentiated osteoclasts opc pretreated csf csf csf exhibited delayed development osteoclasts extended proliferation phase elevated levels csf systemic inflammatory diseases may cause expansion opc pools bone bone marrow blood upon homing bone may lead increase number osteoclasts bone resorption published elsevier inc
aims objectives identify mechanisms subcutaneous fluid administration advanced illness background hydration end life fundamental issue quality care internationally decision making regarding provision artificial hydration advanced illness complicated paucity evidence based guidance despite considerable attention given topic including two recent cochrane reviews focus systematically identifying papers report mechanisms delivering hydration subcutaneously consequently need produce guidance site mode volume rate infusion based empirical evidence design systematic review papers reporting empirical research data methods key databases central medline embase web science cinahl searched september date limitations inclusion criteria focused hypodermoclysis adults within advanced illness population selected studies reviewed quality risk bias assessment conducted included studies results fourteen papers included analysis conducted hospices others long stay units population affected chronic conditions associated ageing studies moderate high quality site mode infusion well described papers rates infusion varied widely allowing little clear consensus guide clinical practice administration subcutaneous fluids conclusions studies report mechanisms artificial hydration provided creating paucity evidence based guidance practice need evidence generated nonmalignant populations ensure applicability large number people advanced illness relevance clinical practice absence sufficiently powered robust evidence mode delivery artificial hydration end life remains gloaming evidence unfounded habit
despite sustained media attention surrounding internet trolling academic studies investigating occurrence rare study aimed provide case study analysis behaviours strategies group alleged twitter trolls referred anti mccanns due continual abuse kate gerry mccann well support thus identify pro mccann way language used construct anti mccanns group identity enhance group cohesion facilitate group disassociation pro mccann group additionally explored given previous research implicated group processes propagation aggressive online conduct multi method approach involving combination ethnographic observations collection online commentary employed data analysed using quantitative content analysis discourse analysis indicated language utilised variety ways anti mccanns construct salient group identity negatively stereotype disassociate pro mccann group findings additionally revealed several strategies employed anti mccann trolls provoke derogate members pro mccann group supporting previous findings linked trolling western media culture characteristics anti social personality disorder implications findings theoretical practical discussed alongside recommendations future research elsevier ltd rights reserved
aimto estimate statistical interactions alcohol policy strength person related risk factors sensation seeking antisocial personality disorder attention deficit hyperactivity disorder related heavy alcohol use designcross sectional survey settingyoung swiss men living within jurisdictions across switzerland participantsa total swiss men mean age years participating cohort study substance use risk factors surf measurementsoutcome measures alcohol use disorder aud defined dsm risky single occasion drinking rsod independent variables sensation seeking antisocial personality disorder aspd attention deficit hyperactivity disorder adhd index alcohol policy strength findingsalcohol policy strength protective rsod odds ratio sensation seeking aspd risk factors rsod aud adhd risk factor aud significant interactions alcohol policy strength sensation seeking identified rsod aud well alcohol policy strength aspd rsod aud interactions indicated protective effects alcohol policy strength rsod aud lost men high levels sensation seeking aspd interactions detected alcohol policy strength adhd conclusionstronger alcohol legislation protects heavy alcohol use young swiss men protective effect lost individuals high levels sensation seeking antisocial personality disorder
mycobacterium tuberculosis causative agent tuberculosis accounts million human deaths annually worldwide despite efforts eradicate tuberculosis still remains deadly disease two best characterized strains tuberculosis virulent hrv avirulent hra provide unique platform investigate biochemical signaling pathways associated pathogenicity delineate biomolecular dynamics may account pathogenicity attenuation virulence tuberculosis compared proteome phosphoproteome profiles hrv hra strains quantitative phosphoproteomic analysis performed using high resolution fourier transform mass spectrometry analysis exponential stationary phases strains resulted identification quantitation proteins along phosphorylation sites derived proteins addition confirming presence previously described tuberculosis phosphorylated proteins identified novel phosphorylation sites quantitative proteomic analysis revealed five fold upregulation proteins belonging virulence associated type vii bacterial secretion system hrv compared hra also identified proteins exhibited changes phosphorylation levels virulent avirulent strains bioinformatics analysis proteins altered level expression phosphorylation revealed enrichment pathways involved fatty acid biosynthesis two component regulatory system data provides resource exploration functional differences molecular level hrv hra ultimately explain molecular underpinnings determine virulence tuberculosis
objective incidence posttraumatic ventriculomegaly ptv shunt dependent hydrocephalus nonaccidental head trauma naht unknown present study authors assessed timing ptv development relationship ptv decompressive craniectomy whether ptv necessitated placement permanent shunt also naht ptv cases categorized temporal profile delay admission evaluated association outcomes discharge methods authors retrospectively reviewed cases patients diagnosed naht throughout year period cases sequential scans obtained evaluated evans index determine earliest time ventricular dilation observed discharge outcomes assessed using king outcome scale childhood head injury score results thirty nine percent patients developed ptv low admission glasgow coma scale gcs score predicted early ptv presentation within week majority ptv naht patients presented subdural hematoma convexity interhemispheric ischemic stroke subarachnoid hemorrhage significantly associated ptv naht patients undergoing intractable intracranial pressure developed ptv patients tended present lower gcs scores develop ventriculomegaly early patients developed hydrocephalus requiring shunt placement conclusions ptv presents early naht particularly performed however authors found ptv naht patients developed shunt dependent hydrocephalus
dna methylation dna repair genes participates dna damage regulation particulate matter metals polycyclic aromatic hydrocarbons pahs adsorbed among others linked adverse health outcomes may modify dna methylation evaluate exposure impact repetitive elements gene specific dna methylation dna damage conducted cross sectional study schoolchildren years old urbanized industrial area metropolitan area mexico city mamc frequently exhibits concentrations safety standards methylation long interspersed nuclear element line dna repair gene oggi apex parp assessed pyrosequencing peripheral mononuclear cells dna damage comet assay dna oxidation ohdg content pah metal contents aerodynamic diameter determined hplc icp aes respectively multiple regression analysis dna methylation dna damage pmio exposure showed significantly associated oxidative dna damage increase cpg sites parp promoter associated increase ohdg increase cpg sites resulted increments respectively increase benzo fluoranthene content associated increase line methylation acenaphthene indene pyrene pyrene concentrations correlated higher dinucleotide methylation ogg apex parp genes respectively vanadium concentration correlated increased methylation selected apex parp cpg sites dna repair gene methylation significantly correlated dna damage specific associated pahs vanadium data suggest exposure components associated differences dna methylation repair genes children may contribute dna damage elsevier rights reserved
order adapt milling machines changing behavior operating due changing tool workpiece contact conditions adaptive controllers advantageous approach control machines feed rate otherwise inaccuracies occur leading poor quality paper model predictive control mpc used control feed rate machine applying parameterized model current state milling process future trend predicted order system delay time used model behavior milling machines velocity control loop continually estimating model parameters run time controller adapts current machine behavior developed solutions maximum likelihood estimators models independent parameters state space representation numerically efficiently calculated estimators used estimate parameters order system delay time iteratively based collected process data two validation studies one emulating online estimation based real data five axis machining center mazak variaxis one simulation study simulated machine carried validate iterative parameter estimation algorithm studies time variant model whose parameters estimated basis developed estimators compared time invariant model controller adapt changing machine behavior ifac international federation automatic control hosting elsevier ltd rights reserved
background aim present study investigate preventive effect costus pictus leaf extract experimental hypothyroidism materials methods forty male wistar rats randomly divided four groups ten rats group control hypothyroid control extract hypothyroid extract rats group receive intervention throughout experimental period rats groups received pretreatment pictus leaf extract weeks subsequently next weeks rats group received propylthiouracil drinking water group received pictus leaf extract group received propyl thiouracil pictus leaf extract results hypothyroid group rats exhibited dramatic increase thyroid stimulating hormone tsh levels concomitant depletion levels thyroid hormones treatment extract resulted remarkable improvement thyroid profile extract produced fold increase plasma free fold increase free fold decrease tsh levels group comparison group treatment extract ameliorated hypercholesterolemia decreased levels plasma reactive protein tumor necrosis factor alpha suppressed tissue oxidative stress prevented hepatic renal damage caused due thyroid hormone depletion group pentacyclic triterpenes alpha beta amyrins identified quantified extract conclusions first study reveal pictus extract therapeutic potential restore thyroid hormone levels prevent biochemical complications due thyroid hormone insufficiency animal model experimental hypothyroidism
objective present study evaluate relationship clinical outcome time day surgery experience level surgeon secondly examined relationship length hospital stay time day surgery retrospective cross sectional cohort design study included patients treated intramedullary nailing aalborg university hospital tibial shaft fractures follow participants completed knee injury osteoarthritis outcome score koos age sex complications length hospital stay start time surgery education level surgeons recorded long term analysis koos assessment shows significant association time day surgery level surgeon experience difference complication rates time day surgery level surgeon experience secondary outcome analysis showed estimated increased risk longer length hospital stay operated trainee night hours compared day hours estimated increased risk longer length stay operated day hours trauma surgeon compared trainee complication rates koos outcome surgery intramedullary nailing influenced time day surgery experience level surgeon lengths hospital stay increase significantly surgery performed night trainee surgeons performed trauma surgeons
well known exposure maternal separation early life causes plastic changes nervous system adulthood occasionally resulting ubiquitous chronic pain however pathogenic mechanisms pain hypersensitivity remain unclear authors examined involvement corticosterone orofacial mechanical hypersensitivity induced establish rat model pups placed isolated cages min kept temperature controlled environment degrees mechanical allodynia whisker pad skin adulthood induced significantly suppressed successive postnatal subcutaneous administration glucocorticoid receptor antagonist mifepristone corticosterone levels increased serum rats successive postnatal administration subcutaneous corticosterone naive rats induced mechanical allodynia whisker pad skin number receptor immunoreactive trigeminal ganglion neurons innervating whisker pad skin significantly increased rats decreased following subcutaneous administration mifepristone number neurons innervating whisker pad skin also significantly increased following successive postnatal administration subcutaneous corticosterone naive rats moreover mechanical allodynia suppressed min administration antagonist whisker pad skin rats findings suggest increase neurons innervating whisker pad skin via enhanced neonatal corticosterone signaling plays important role orofacial mechanical allodynia adulthood
slot width ratio twin box girder plays important role aerodynamic performance corresponding bridge therefore necessary investigate viv performance twin box girder various slot width ratios evaluate effectiveness present viv countermeasures considering influence different slot width ratio series wind tunnel tests present study firstly investigated viv performance twin box girder suspension bridge six representative slot width ratios ranging four countermeasures including increasing structural damping ratio installing grid plates wind barriers guide vanes checked comprehensively evaluated aim identifying effective viv control measure experimental results showed viv performance twin box girder slot width ratio single box girder superior central slot maximum normalized heaving viv amplitude occurs slot width ratio geometrical scale model around scale model around respectively significant difference torsional viv responses two models different geometrical scale found slot width ratio comparison viv countermeasures slot width ratios suggested increasing damping ratio helpful reducing viv responses installing guide vanes may adverse effects application grid plates wind barriers positive effects suppressing heaving viv responses effectiveness grid plates obvious decrease grid porosity furthermore application grid plates grid porosity perfectly enable viv performance twin box girder bridge meet requirements sperling indicator wind resistance specification china elsevier ltd rights reserved
undergraduate stem instruction increasingly uses educational technologies support problem solving activities educational technologies offer two key features may make particularly effective first problem solving activities involve multiple visual representations many students difficulties understanding constructing connecting representations educational technologies provide adaptive support helps students make sense visual representations second many problems visual representations involve collaboration however students often collaborate effectively educational technologies provide collaboration scripts adaptively react student actions prompt engage specific effective collaborative behaviors observations lead hypothesis tested adaptive collaboration script enhances students learning content knowledge visual representations conducted quasi experiment undergraduate students introductory chemistry course control condition worked traditional worksheet asked students collaboratively make sense connections among multiple visual representations experimental condition worked problems embedded educational technology provided adaptive collaboration script experimental condition showed significantly higher learning gains transfer test immediately intervention complex concepts midterm exam three weeks later elsevier ltd rights reserved
paper presents optimal designs two analogue complementary metal oxide semiconductor cmos amplifier circuits namely differential amplifier current mirror load two stage operational amplifier modified particle swarm optimization pso called craziness based particle swarm optimization crpso technique applied minimize total mos area designed circuits crpso highly modified version conventional pso adopts number random variables better faster exploration exploitation capability multidimensional search space integration craziness factor fundamental velocity term pso brings diversity particles also pledges convergence close global best solution proposed crpso based circuit optimization technique reassured free intrinsic disadvantages premature convergence stagnation unlike differential evolution harmony search artificial bee colony abc particle swarm optimization pso simulation results achieved two analogue cmos amplifier circuits establish efficacy proposed crpso based approach abc pso terms convergence haste design conditions design goals optimally designed analogue cmos amplifier circuits occupy least mos area show best performance parameters like gain power dissipation compared reported literature copyright john wiley sons ltd
objective gain deeper understanding thai teenage parents perspectives experiences reasoning becoming teenage parent gender perspective design exploratory design using grounded theory methodology semi structured interviews used collect data interview guide developed pilot study undertaken interviews performed two different occasions second trimester pregnancy infant months old setting province western part thailand participants selection heterogeneous group teenage parents continued saturation reached describe glaser strauss inclusion criteria participants heterosexual couples years age cohabiting expecting first child findings core category struggling motherhood coping fatherhood comprises descriptions process teenagers first learned pregnancy child six months old teenagers failed use contraceptives led unintended parenthood parenthood became turning point teenagers started change behaviours lifestyle pregnancy adapted relationships partner family family commitments facilitator support given families finally becoming parent describes ways dealing parental role engaging parental activities reestablishing goals life teenage parents reproduced traditional gender roles caring mother breadwinning father respectively key conclusions struggling motherhood coping fatherhood referred parents stories struggled coped life changes parental role became unintentionally pregnant accepted parenting finally became parents becoming parents main concerns teenage parents caring mother breadwinning father implications practice study contributes deeper understanding thai teenage parents experiences becoming parent might improve health care professionals adaptation care teentranatanage parents inspire tailor care specifically teenager needs early pregnancy parenthood elsevier ltd rights reserved
study tumor growth biology computer based models currently area active research different simulation techniques used describe complexity real tumor behavior among cellular automata based simulations provide accurate tumor growth graphical representation time keep simpler implementation automata computer programs several authors recently published relevant proposals based latter approach solve tumor growth representation problem development strategies accelerating simulation model strategies achieve computational performance cellular models representation appropriate selection data types clever use supporting data structures however today multithreaded processing techniques multicore processors used program cellular growth models generality paper presents new model incorporates parallel programming multi manycore processors implements synchronization requirement necessary implement solution proposed parallel model proved using java program implementations two different platforms chipset intel one node processors cluster university improvement resulting introduction parallelism model analyzed paper comparing standard sequential simulation model currently used researchers mathematical oncology
exendin glucagon like peptide receptor agonist demonstrated cytoprotective actions beyond glycemic control recent studies aims present study investigate effects exendin high glucose induced cardiomyocyte apoptosis possible mechanisms rat cardiomyocytes divided groups normal glucose group group group exendin group group cardiomyocyte apoptosis evaluated double staining annexin fluorescein isothiocyanate fitc propidium iodide flow cytometry intracellular reactive oxygen species ros production detected dichlorodihydrofluorescein diacetate dchf incubation fluorescence microscopy phosphoinositide kinase pik pathway inhibitor added medium group western blot analysis proteins analyzed involved oxidative stress associated proteins heme oxygenase nuclear factor related factor nrf apoptosis associated proteins caspase bax cell lymphoma bcl akt akt treatment induced cardiomyocyte apoptosis clearly upregulated ros production exendin incubation also ameliorated cardiomyocyte apoptosis decreased ros level significantly nrf protein expression levels decreased significantly group levels elevated exendin intervention furthermore exendin attenuated induced higher protein expression including cleaved caspase bax increased expression bcl protein however impacts exendin counteracted significantly incubation addition exendin ameliorated induced akt akt lower expression impact also suppressed exendin ameliorates induced cardiomyocyte apoptosis mechanisms may involve anti oxidative stress via nrf system well intervention pik akt signaling pathway
introduction parallel rapid growth access new technologies increase problematic use especially among children adolescents although research field increasing studies mainly developed community characteristics associated problematic use unknown samples require clinical care therefore aim study analyze relationship problematic use video games upv internet upi personality traits behavior problems clinical sample children adolescents methodology sample consists patients examined clinical psychology consultation mental health unit children adolescents university hospital santiago compostela data obtained self reports rating scales filled parents results participants present upi upv children adolescents upnt lower levels openness experience conscientiousness agreeableness higher levels emotional instability global impulsivity externalizing behavior problems well attention thought problems conclusions upnt problem emerges important issue clinical care children adolescents study child youth care units needed understanding psychopathological profile children adolescents upnt allow development differential specific interventions
use electronic communications open networks bring along serious risks fundamental rights citizens cloud computing rfids ambient intelligence software agents bring danger homo conectus example possibilities control brought along technologies must analyzed employment relationship must enquired existence right disconnect
background objective headache common health problem may present neurological diseases chronic diseases adverse effect emotional status think headache common disease asthmatic patients study aims evaluate presence headache risk factors patients asthma methods ninety three patients asthma healthy control subjects included study presence headache evaluated according revised criteria international classification headache disorders edition icdh asthma control test act performed determine asthma control status beck depression inventory bdi beck anxiety inventory bai performed participants demographic features used medications presence headaches recorded results fifty eight patients asthma headaches whereas control subjects headaches thirty two patients tension type headache patients migraine type headache patients types headaches frequency headaches significantly higher patients asthma compared healthy control subjects significant correlation migraine type headache inhaled steroid use presence allergies conclusion migraine type tension type headaches common patients asthma compared overall population frequency migraine type headache higher patients asthma allergies low respiratory function test scores
methods environmental assessment certification green buildings increasingly adopted local governments entities means meeting environmental often energy related goals literature building environmental assessment examined tools interpreted stakeholders design construction less attention paid interpretation usage objects policy despite channel potentially huge impact based case study emergence green building israel drawing socio technical literatures paper explores meanings attributed building environmental assessment policy context finds meanings include platform divergent environmental goals proxy measure greenhouse gas abatement analysis suggests policy makers significance green building lies constituting set environmental benchmarks standard gains currency black boxed policy object open discussion needed various logics driving use green building tools public policy hope achieve
objective purpose study test causal effects physicians nonverbal involvement medical error disclosure outcomes methods hospital outpatients randomly assigned two experimental treatment groups first group watched video vignette verbally effective nonverbally involved error disclosure second group exposed verbally effective nonverbally uninvolved error disclosure patients responded seven outcome measures results patients nonverbally uninvolved error disclosure treatment group perceived physician apology less sincere remorseful compared patients involved disclosure group also rated implications error severe likely ascribe fault physician indicated higher intent change doctors disclosure conclusion results study imply nonverbal involvement medical error disclosures facilitates accurate patient understanding assessment medical error consequences health quality life practice implications context disclosing medical errors nonverbal involvement increases likelihood physicians able continue caring patient thus providers advised consider adopting communication skill medical practice elsevier ireland ltd rights reserved
general analysis construction waste quantification estimates total amount waste generated considering total floor area project however countries houses usually sold units within collective housing buildings may need consider parameters sense research states new proposal quantify waste generated construction mediterranean residential buildings considering total floor area project also number dwellings several newly built residential building works analyzed results obtained offer two models estimating weight volume construction waste generated type constructions around mean deviation found model predictions data collected projects published previous research works moreover including variables management carried working team good practices implemented minimize cow generation may result maximum deviations model finally model serve construction stakeholders developing current waste management plans reports required regulations order estimate amount construction waste generated therefore optimize management elsevier ltd rights reserved
individuals vary tendency bind signals multiple senses set sights sounds one individual may frequently integrate multisensory signals experience unified percept whereas another individual may rarely bind often experience two distinct sensations thus binding integration tendency specific individual clear plastic tendency adulthood sensory experiences may cause change conducted exploratory investigation provides evidence brains tendency bind spatial perception plastic change following brief exposure simple audiovisual stimuli exposure temporally synchronous spatially discrepant stimuli provides effective method modify results inform current theories brain updates internal model surrounding sensory world well future investigations seeking increase integration tendencies
paper focuses application new learning materials university west bohemia pilsen faculty mechanical engineering department machine design study materials based injection mould previously applied practice main advantage learning materials help students become familiar master design issues practical viewpoint learning material written structured unified form following sequence basic information injection mould given introduction second part student view active two colour models coloured according function machining technology learning materials include drawing documentation main assembly subassemblies consist manufactured
good behavior game gbg classroom management strategy uses interdependent group oriented contingency promote prosocial behavior decrease problem behavior meta analysis synthesized single case research scr gbg across studies representing students pre kindergarten grade tauu effect size across phase contrasts confidence interval indicating substantial reduction problem behavior increase prosocial behavior participating students five potential moderators examined emotional behavioral disorder ebd risk status reinforcement frequency target behaviors gbg format grade level findings suggest gbg effective reducing disruptive task behaviors students risk ebd benefit intervention implications research practice discussed
centella asiatica herbaceous plant asian traditional medicine besides wound healing plant recommended treatment care various skin conditions dry skin leprosy varicose ulcers eczema psoriasis triterpene saponins known centellosides main metabolites associated beneficial effects considering interest high value active compounds need develop biosustainable economically viable processes produce previous work using asiatica plant cell culture technology demonstrated efficient conversion amyrin derivatives centellosides opening new way access biomolecules current study aimed increasing production centellosides asiatica plant cell cultures herein report application new elicitor coronatine combined addition amyrin enriched resins potential sustainable precursors centelloside pathway positive synergistic effect centelloside production results show coronatine powerful elicitor increasing centelloside production treatments sustainable natural sources amyrins enhance centelloside yields process scaled orbitally shaken cellbag thereby increasing capacity system producing biomass centellosides
paper study labeled spanning forest klsf problem undirected graph whose edges labeled integer positive value given aim find spanning forest input graph minimum number connected components upper bound number labels problem related minimum labeling spanning tree problem several applications real world paper compare several metaheuristics solve hard problem particular proposed intelligent variable neighborhood search vns shows excellent performance obtaining high quality solutions short computational running time approach integrates vns complementary approaches machine learning statistics experimental algorithmics order produce high quality performance completely automate resulting optimization strategy
inappropriate management practices cerrado soil cause important negative impacts ecosystem especially converting native vegetation pastures crops plantation significantly losses natural cerrado reported current remaining natural vegetation area smaller land cover therefore sustainable practices required recover protect biome reason work aimed evaluate effect grass legumes species coir geotextile seasonal cycle rain drought soil abandoned pasture cerrado southeastern brazil several soil parameters examined including physical chemical compositions microbial biomass smb microbial viability plant species used andropogon gayanus cgg coir geotextile grass calopogonium mucunoides arachis pintoi cgl coir geotextile legumes general cgl beneficial effects soil fertility cgg terms total soil organic carbon total nitrogen cgl treatment showed smb values twice control higher cgg microbial populations actinobacteria fungi increased cgg cgl better improvement microbial growth observed cgl actinobacteria prevalent group soil surface greater depths results indicated calopogonium mucunoides aggressive species inhibits growth arachis pintoi appropriate use geotextiles associated non weed non alien vegetation represents viable technique improving total soc smb nutrients nitrogen phosphorus increase microbial populations published elsevier
fully autonomous intracranial device built continually record neural activities different parts brain process sampled signals decode features correlate behaviors neuropsychiatric states use features deliver brain stimulation closed loop fashion paper describe sampling stimulation aspects device first describe signal processing algorithms two unsupervised spike sorting methods next describe lfp time frequency analysis feature derivation two spike sorting methods spike sorting includes novel approach constructing dictionary learning algorithm compressed sensing framework present joint prediction scheme determine class neural spikes dictionary learning framework second approach modified osort algorithm implemented distributed system optimized power efficiency furthermore sorted spikes time frequency analysis lfp signals used generate derived features including cross frequency coupling spike field coupling show derived features used design development novel decode closed loop control algorithms optimized apply deep brain stimulation based patient neuropsychiatric state control algorithm define state vector representative patient impulsivity avoidance inhibition etc controller parameters optimized apply stimulation based state vector current state well historical values overall algorithm software design implantable neural recording stimulation system uses innovative adaptable reprogrammable architecture enables advancement state art closed loop neural control also meeting challenges system power constraints concurrent development ongoing scientific research designed define brain network connectivity neural network dynamics vary individual patient level vary time
objective acpas associated bone destruction aim study evaluate association acpa bone destruction patients distinct inflammatory disorder psa methods used baseline data large observational study psa patients preparing initiate treatment adalimumab analyse demographic disease characteristics acpa status ensure homogeneous psa study population patients active psoriatic skin manifestations met classification psoriatic arthritis criteria psa included analyses thereby minimizing risk including misdiagnosed patients multiple logistic regression analyses used explore potential associations acpa seropositivity bone destruction results psa patients met strict inclusion criteria positive acpa acpa positive patients significantly higher swollen joint counts joint das values acpa negative patients significantly higher rates erosive changes dactylitis multiple logistic regression analysis confirmed association acpa seropositivity fold increase risk erosive disease conclusion previously shown acpa associated bone destruction psa suggesting osteocatabolic effect acpa confined also detectable different pathogenetic context distinct disease entity trial registration clinicaltrials gov nct
advance world wide web www technology people easily share content web including geospatial data web services thus big geospatial data management issues start attracting attention among big geospatial data issues research focuses discovering distributed geospatial resources resources scattered www users find resources interests efficiently www web search engines addressing web resource discovery issues envision geospatial web geoweb also requires geoweb search engines realize geoweb search engine one first steps proactively discover geoweb resources www hence study propose geoweb crawler extensible web crawling framework find various types geoweb resources open geospatial consortium ogc web services keyhole markup language kml environmental systems research institute inc esri shapefiles addition apply distributed computing concept promote performance geoweb crawler result shows targeted resources types geoweb crawler discovered geospatial services datasets result proposed geoweb crawler framework proven extensible scalable provide comprehensive index geoweb
bound state vector soliton solutions coupled variable coefficient higher order nonlinear schrodinger equations describe simultaneous propagation nonlinear waves inhomogeneous optical fiber investigated introducing auxiliary functions derive bilinear forms corresponding constraints variable coefficients symbolic computation construct one two soliton solutions see variable coefficients equations affect soliton structures different choices variable coefficients obtain cubic periodic parabolic solitons bound state solitons interactions analyzed graphically
spread spectrum technique introduced mitigating electromagnetic interference emi problems many class circuits paper particular emphasis switching converters consider common efficient known spreading techniques looking spreading parameters ensure highest emi reduction lowest performance reduction circuit spreading applied result interesting tradeoff emi reduction performance drop also emi reduction considering different emi victim models proposed analysis supported measurements two switching converters based pulse width modulation based resonant converter class
regression testing process retesting system environment changed many techniques aim find cheapest subset regression test suite achieves full coverage recently observed tester might want range solutions providing different trade offs cost one forms coverage multi objective optimisation problem paper develops multi objective agenda adapting decomposition based multi objective evolutionary algorithm moea experiments evaluated four approaches classic greedy algorithm non dominated sorting genetic algorithm nsga moea fixed value parameter moea tuning used choose value used six programs sir repository one larger program voidauth experiments moea tuning effective technique relative performance techniques varied although moea fixed outperformed nsga larger programs space voidauth elsevier inc rights reserved
aims better understand impact clinical course multiple sclerosis disability employment absenteeism related factors materials methods study included respondents north american research committee multiple sclerosis registry spring update survey canadian residents aged years reported relapsing remitting rrms secondary progressive spms primary progressive ppms rrms spms participants combined form relapsing onset rms group compared ppms group regarding employment status absenteeism disability multivariable logistic regression used examine relationship employment related outcomes factors may affect relationships results survey respondents years age ppms group higher proportion males older mean age time survey time diagnosis rms group female sex age age diagnosis cognitive hand function impairment fatigue higher disability levels comorbidities diagnosis ppms associated working adjustment disability employed ppms sub group reported similar levels absenteeism employed rms sub group limitations limitations study include self report information possibility participants may fully represent working age population conclusions employment status absenteeism negatively affected disability cognitive impairment fatigue findings underscore need therapies prevent disability progression symptoms negatively affect productivity persons enable persist workforce
objectivethe objective study compare sex differences bone deficits among adolescents anorexia nervosa identify correlates bone health methodelectronic medical records patients years age dsm diagnosis evaluated eating disorders program stanford dual energy ray absorptiometry dxa march february retrospectively reviewed whole body bone mineral content scores bone mineral density bmd scores multiple sites recorded using bone mineral density childhood study bmdcs reference data resultsa total males females included median age years interquartile range iqr median duration illness months iqr using linear regression analyses significant sex differences bone deficits found lumbar spine total hip femoral neck whole body controlling age mbmi duration illness lower mbmi significantly associated bone deficits sites adjusted models discussionthis first study evaluate sex differences bone health among adolescents using novel dsm criteria robust bmdcs reference data find significant sex differences bone deficits among adolescents except higher proportion females femoral neck bmd scores degree malnutrition correlated bone deficits sites wiley periodicals inc int eat disord
last two decades general purpose computer become increasingly powerful affordable turn led emergence highly sophisticated applications enable high fidelity simulation dynamic systems also automatic code generation implementation real time control electric machine drives today electric drives power electronic systems controls become complex use widely increasing sectors distributed power generation traction hybrid vehicles industrial home electronics automotive marine aerospace systems etc advances microprocessors microcomputers microcontrollers dsp fpga etc power semiconductor devices made tremendous impact performance electric motor drives due advancement software tools like matlab simulink real time simulators used extensively many engineering fields industry education research institutions result inclusion real time simulation applications modern engineering provides great help researcher academicians overview real time simulations electrical machines drives herewith presented used modern engineering practices paper discusses various existing real time simulation techniques proposes general purpose computer based platform real time simulation benefits performance covered detail
papers focused governor fundamental speed control basics focus paper fundamental understanding automatic voltage regulator basics voltage control mvar load sharing discussions focus non complex islanding applications upstream oil gas downstream petrochemical facilities large motor starting gas turbine step load capability mechanical tripping online generator load shedding preserve continued system operation electrical protection philosophy basics maintain system stability
small proportion video game players develop uncontrolled gaming behavior dysfunctional cognitive control circuit may explain excessive behavior therefore current study investigated whether problem garners characterized deficits various aspects cognitive control inhibitory control error processing attentional control measuring brain activation using functional magnetic resonance imaging nogo stroop task performance addition impulsivity attentional control measured using self reports participants comprised problem garners compared matched casual gaming controls results indicate significantly increased self reported impulsivity levels decreased inhibitory control accompanied reduced brain activation left inferior frontal gyrus ifg right inferior parietal lobe lpl problem garners relative controls significant hypoactivation left ifg problem garners also observed stroop task performance groups differ behavioral self reported measures attentional control evidence found reduced error processing problem garners conclusion current study provides evidence reduced inhibitory control problem garners attentional control error processing mostly intact findings implicate reduced inhibitory control elevated impulsivity may constitute neurocognitive weakness problem garners elsevier ireland ltd rights reserved
purpose pharmacist role providing care transgender gender nonconforming tgnc patients within medical home model care described summary comprehensive transgender services clinic established february new mexico clinic services provided informed consent model care opposed traditional gate keeper approach clinic interprofessional team consists clinical pharmacist psychiatrist nurse practitioner endocrinologist diabetes educator massage therapist nurse nutritionist medical assistants clinical pharmacist served following roles assessing health literacy tailoring consent process patient literacy level initiating depth discussion medical risks benefits cross sex hormone therapy well alternatives discussing typical timelines physical outcomes discussing patient expectations goals csht discussing different formulations helping determine formulation best suited meeting patient goals helping team obtain prior authorizations csht managing risk reduction strategies smoking cessation weight loss involvement pharmacist clinic improved care access quality tgnc patients southwestern united states conclusion pharmacist interprofessional team staffing clinic tgnc people assumed multiple responsibilities helped improve patient care
violent video games players engage virtual aggressive behaviors exposure virtual aggressive behavior induces short term changes players behavior previous study violence related version racing game carmageddon tdr increased aggressive affects cognitions behaviors compared non violence related version study investigates differences neural network activity playing versions video game functional magnetic resonance imaging fmri recorded ongoing brain activity young men playing violence related non violence related version video game carmageddon image time series decomposed functional connectivity patterns using independent component analysis ica template matching yielded mapping established functional brain networks patterns revealed decrease connectivity within brain networks violence related compared non violence related condition three sensory motor networks reward network default mode network dmn right lateralized frontoparietal network playing violent racing games may change functional brain connectivity particular even controlling event frequency reward network dmn changes may underlie short term increase aggressive affects cognitions behaviors observed playing violent video games ibro published elsevier ltd rights reserved
software software deliverables high impact fields software deployed maintained continuously till becomes obsolete various activities come maintenance include adaptive corrective predictive maintenance even though software maintenance tagged core field software engineering compared software related activities almost time resources allotted maintenance activities according related work little research going field maintenance article highlights scope maintenance related research identifying factors directly indirectly affect maintenance activity turn make estimation activities easy implementation effective software maintenance model high impact quality software thereby customer satisfaction article aims project effective maintenance model reduces cost rework improves customer satisfaction index
objectives assessed intrauterine device iud preference among women presenting emergency contraception probability pregnancy among concurrent oral levonorgestrel lng plus lng iud users methods offered women presenting single family planning clinic cuta iud copper iud oral lng plus lng iud two weeks iud insertion participants reported results self administered home urine pregnancy test primary outcome failure defined pregnancies resulting intercourse occurring within five days prior iud insertion results one hundred eighty eight women enrolled provided information regarding current menstrual cycle recent unprotected intercourse sixty seven chose copper iud chose oral lng plus lng rid probability pregnancy two weeks oral lng plus lng iud use positive pregnancy test treatment occurred woman received oral lng plus lng iud reported multiple episodes unprotected intercourse including episode days prior treatment conclusions study participants seeking desired iud preferentially chose oral lng lng iud copper rid neither group treatment failures including option oral lng concomitant insertion lng iud counseling may increase number users opt initiate highly effective reversible contraception implications consideration given lng iud insertion concomitant use oral lng use combination may increase number women initiating highly effective contraception time visit elsevier inc rights reserved
paper proposes ultra lightweight cipher anu anu balanced feistel based network anu supports bit plaintext bit key length total rounds needs gate equivalents bit key length less compared existing lightweight ciphers memory size minimal power consumption less needs dynamic power present cipher consumes power paper furnishes complete security analysis anu cipher design security analysis shows anu attain ample security level linear differential cryptanalysis biclique attack zero correlation attack algebraic attack biclique cryptanalysis provides maximal data complexity anu cipher needs less gate equivalents also consumes less power less memory requirement anu cipher best suited applications like internet things design anu cipher positive impact field lightweight cryptography copyright john wiley sons ltd
simulations becoming popular analysis complex behavior large scale systems immense inputs outputs increasing demand efficiently store manage analyze massive simulation outputs hadoop mapreduce used various applications speed process analyzing large amounts datasets paper present arls action reviewer large scale simulations mapreduce based output analysis tool simulation outputs arls clusters distributed storages using hadoop automatically composes map reduce functions process simulation outputs arls applied sam surface air missile simulator sam simulator developed analyze dynamics missile designing air defense systems arls takes large amount unstructured simulation outputs sam simulator automatically generates map reduce functions analyze missile aircraft component sam simulator executes map reduce jobs parallel results experiments show arls efficiently analyze large amount unstructured simulation datasets distributing datasets computations cluster commodity machines elsevier ltd rights reserved
current study explored individual differences endorsement aggressive behaviors thoughts relate individual levels tolerance prejudice toward immigrants established prejudice correlates social dominance orientation sdo ethnic groups ratings among adolescents participants age girls completed readiness interpersonal aggression inventory tolerance prejudice questionnaire measures sdo ethnic groups ratings results indicated higher individual endorsement aggression related higher prejudice sdo lower tolerance ethnic groups ratings patterns endorsement aggression related habitual socially determined aggressive acts stable needs hurt others source satisfaction significantly correlated prejudice conversely relationship prejudice endorsement impulsive actions lacking emotional control resulted less marked results highlight cognitive spectrum prejudice individual levels endorsement aggression may play significant triggering role adolescence findings may implications future studies interventions aimed reducing prejudice already young ages
current study investigate factors facilitate otherwise obstruct reparations perpetrating group muslims victim group christians study reveals among muslim participants role dual abrahamic categorization positively predicting reparation attitude towards christians mediated first group prosocial emotions empathy collective guilt towards latter group addition relative muslim prototypicality negatively predicted dual abrahamic categorization two prosocial emotions empathy collective guilt turn mediated role relative ingroup prototypicality negatively predicting reparation attitude moreover hypothesized found roles empathy collective guilt predicting reparation intention manifested participants willingness engage collective action behalf victim group significant mediated reparation attitude findings shed light importance relationship perpetrating group shared identity victim group reduced ingroup focus support making reparations victim group theoretical implications study limitations practical strategies highlighting decrease relative muslim prototypicality discussed
idiopathic pulmonary fibrosis accounts lethal diffuse fibrosing lung disease described accumulation fibroblasts loss damage lung epithelial cells causing respiratory failure excessive ros level impairs cellular redox level inflammatory cell infiltration abnormal collagen production induce extracellular matrix accumulation nuclear factor erythroid related factor nrf regulates antioxidant associated genes phytochemical target chemoprevention preventive effect organosulfuric compound diallyl sulfide das tgf beta induced fibrosis lung mrc fibroblast investigated study mrc cells pretreatment das tgf stimulation das suppressed collagen production tgf beta induced cells attenuating smad phosphorylation activating level das inhibited tgf beta induced myofibroblast formation decreasing ros enhancing nrf related antioxidant enzyme myofibroblast apoptosis das potential dietary agent inhibit tgf beta induced fibrosis prevent oxidative stress induced pulmonary fibrosis elsevier ltd rights reserved
paper shown new way proceed concerns simulation high speed railway systems based configurations approach relies highly efficient open source software opendss solve electrical circuits resulting model configurations moreover python open source programming language used interface opendss processing input data presentation results effectiveness tool demonstrated several test cases practical system using real traffic data
renal damage common problem diabetes alloxan potent hyperglycemic diabetogenic molecule induce diabetes oxidative stress related mechanisms hypothesize alloxan induced renal damage associated alterations tgf extracellular matrix metalloproteinases test hypothesis established animal model male abino rats induced diabetes intraperitoneal injection alloxan monohydrate rats fasting blood glucose levelmg considered diabetic sacrificed day intervals tissue levels malondialdehyde glutathione levels markers oxidative stress serum mmp measured expression patterns tgf evaluated using western blot immunohistochemical methods timp expression pattern determined using pcr immunohistochemical methods alloxan treatment induced histological features renal damage inflammation fibrosis associated deterioration renal functions elevated blood urea nitrogen creatinin levels hyperglycemia oxidative stresss increased malondialdehyde decreased glutathione levels expression tgf protein profibrogenic protein proapoptotic protein alterations extracellular matrix proteins low level serum mmp expression timp alterations tgf extracellular matrix metalloproteinases contribute pathogenesis alloxan induced renal damage
background protracted febrile myalgia rare form vasculitis diagnosed patients familial mediterranean fever objective present case familial mediterranean anklosing spondylitis anti tnf therapy three years developed protracted febrile myalgia syndrome methods case report results year old woman known familial mediterranean fever anklosing spondylitis years presented fever diarrhea intermittent abdominal pain severe diffuse muscular pain lasting two weeks patient investigated infection focus patient diagnosed protracted febrile myalgia four weeks onset symptoms prednisolone per day applied fever muscle pain resolved within hours conclusion coexisting ankylosing spondylitis disease use anti tnf treatment patients familial mediterranean fever could confounding factor investigation fever steroid therapy dramatic response
purpose evaluate impact array nongeographic patient within year temporal factors variation medicare imaging utilization methods using cms chronic conditions data warehouse identified imaging events nationally per medicare beneficiaries quarterly basis also stratified imaging utilization variety clinical sociodemographic patient factors data summarized descriptively results quarterly basis mean median imaging utilization highest second quarter imaging events per beneficiaries respectively lowest fourth quarter respectively year imaging events per beneficiaries increased progressively increasing patient comorbidities conditions events conditions events conditions events conditions events imaging utilization also higher dual medicaid eligibility beneficiaries others versus events eligible medicare owing end stage renal disease versus age disability versus respectively imaging utilization showed additional variation beneficiary age gender ethnic group conclusions medicare population utilization medical imaging varies greatly association variety patient within year temporal factors previously received little attention radiologists embark risk bearing contracts timing length arrangements carefully considered well specific features patient population attributed practices
recent years emergence many intelligent autonomous systems possible due tremendous advancement various technologies like computer vision automation control engineering sensor technology one intelligent system autonomous underwater vehicle auv ocean floor mapping sonar technology success autonomous smart precise intelligent system depends accurate navigation unmanned vehicle longer period time precise objects detection ocean floor sonar image processing paper describes various algorithms used purpose investigates computational payloads dynamic system high computational payload requirement system parallel processing reconfigurable field programmable gate array proposed higher performance
pulsed thermography widely used nondestructive testing method offers many advantages material defect detection however existing methods pulsed thermographic data processing aim enhance defect signals single thermal image whereas automatic defect detection achieved instead laborious time consuming visual inspection processed images required draw final conclusions usually impossible visually inspect images therefore manual selection informative images often required step thermal image processing probably resulting oversight necessary defect information overcome drawbacks existing methods hyper image segmentation method proposed study analyzes thermographic data simultanedtisly achieve automatic defect detection avoid risk losing information specifically iterative defect detection procedure designed basis laplacian eigenmap algorithm results case study carbon fiber reinforced plastic cfrp materials show feasibility proposed method
nurses knowledgeable regarding importance health promoting activities healthy eating physical activity stress management sleep hygiene maintaining healthy relationships however knowledge may translate nurses self care nurses may follow recommended guidelines physical activity proper nutrition long hours work overload shift work associated nursing practice stressful contribute job dissatisfaction burnout health consequences obesity sleep disturbances purpose article provide overview research examining nurses participation health promoting behaviors including intrinsic extrinsic factors may influence nurses participation activities article also provides recommendations perioperative nurse leaders regarding strategies incorporate nursing workplace improve health staff nurses increasing health promoting behaviors aorn inc
plant leaves vital organ plant photosynthesis directly reflects plant growth nutrition status internal physicochemical property model based reflection transmission plant leaf indirectly reflects information matter energy exchange process plant growth information premise foundation plant growth process fine management optical properties plant leaves plays great significant role field crop nutrition diagnosis plant morphological structure based remote sensing field virtual plant light transmission simulation computer graphics brdf bidirectional reflectance distribution function mainly focused spatial distribution spectral characteristics reflected light surface object characteristics characterize crop growth parameters accurately efficiently acquiring optical properties information plant leaves also great advantages research application remote sensing agriculture order better apply brdf technology agricultural remote sensing paper focus brdf measurement device model development classification application field plants remote sensing eventually although brdf technology still early exploration stage facing many tough challenges promising future terms digital agriculture development
curcumin potent antitumor agent objective study explore interaction curcumin pgk oncogene foxd mir axis prostate cancer therapy mirna microarray analysis used identify mirnas upregulated curcumin treatment mir dramatically upregulated curcumin cells treated antimir combination curcumin followed examining cell viability migration bioinformatics analysis used investigate target genes mir interaction mir pgk evaluated dual luciferase assay since foxd important regulation mir explored whether curcumin regulated foxd expression foxd also ectopically overexpressed investigate effects curcumin regulation mir curcumin treatment significantly upregulated mir decreased prostate cancer cell proliferation migration effects attenuated anti mir transfection mir overexpression curcumin treatment inhibited pgk expression ectopic expression pgk antagonized curcumin antitumor effects foxd upregulated mir ectopic expression foxd synergized curcumin upregulating mir expression curcumin inhibits prostate cancer upregulating mir pgk downregulated mir foxd upregulation essential antitumor effect curcumin
human prosociality often assumed emerge exerting reflective control initial selfish impulses however recent findings suggest prosocial actions also stem processes fast automatic intuitive attempt clarify prosocial behavior may intuitive examining prosociality form reward seeking using event related potentials erps explored whether neural signature rapidly encodes motivational salience event predict intuitive prosocial motivation participants allocated varying amounts money charities initially labelled high low empathy targets conditions promoted intuitive reflective decision making consistent predictions amplitude centroparietal regions greater giving involved high empathy targets low empathy targets deciding intuitive conditions reflective conditions alternatively elicited earlier frontocentral positivity related response inhibition regardless target findings suggest prosocial decision making larger amplitude could signal intuitive prosocial motivation predict subsequent engagement prosocial behavior work offers novel insight prosociality may driven intuitive processes roots behaviors
children show stronger cooperative behavior experimental settings get older little known environment child shapes development adults prosocial behavior toward strangers markedly decreased low socioeconomic status ses neighborhoods suggesting environmental harshness negative impact prosocial behaviors similar results obtained year olds recruited low high ses schools current study investigate whether findings generalize younger age group developing country specifically worked sample thirty nine year olds two neighborhoods single city romania using quality dictator game offers greater resolution previous measures find children living harsher neighborhood behave less prosocially toward stranger children living less harsh neighborhood
tripartite motif containing trim transcriptional regulator acting essential corepressor kruppel associated box zinc finger domain containing proteins multiple tissue cell types increasing number studies investigated function trim however prognostic value breast cancer remains unclear present study expression trim identified significantly higher cancerous compared healthy tissue samples furthermore demonstrated trim expression significantly correlated several clinicopathological characteristics patients mutation tumor recurrence elston grade tumor addition protein protein interaction network created illustrate interactions trim proteins prognostic value trim patients investigated using kaplan meier plotter database revealed high expression trim predictor poor prognosis patients conclusion results present study indicate trim provides survival advantage patients novel prognostic biomarker addition therapeutic target treatment
aim study determine stresses structures knee using finite element method patients knee osteoarthritis different angles study comprised female patients right knee osteoarthritis patients largest smallest median angle selected angles determined degrees degrees degrees respectively computed tomography magnetic resonance images right knee taken made using mimics program bone soft tissues knee joint converted solid model using solidworks program finally physiological conditions appropriate standing position applied analyses made ansys workbench program comparing stresses cartilages patients knee osteoarthritis angles degrees degrees degrees highest stress value found tibial cartilage femoral cartilage patient degrees angle patellar cartilage patient degrees angle comparing stresses knee structures patients lowest stress structures patient degrees angle according results high low angle knee joint alignment deteriorates may adversely affect osteoarthritis process increasing degeneration knee joint structures therefore angle taken account knee rehabilitation
complex tasks internet malicious benign collectively carried clusters addresses demonstrate often possible discover clusters processing data sets logs collected various vantage points network obviously clusters discovered way malicious nevertheless show malicious clusters accurately distinguished benign ones simply using blacklist without requiring complex analysis verify malicious behavior paper first propose novel clustering framework applied data sets network interactions identify clusters carrying specific task collectively given list identified clusters addresses present simple procedure spot malicious ones using blacklist show choosing parameter proposed clustering process optimally using blacklist hence making blacklist aware significantly improve overall ability detect malicious clusters furthermore mathematically show even blacklist poor accuracy used detect malicious clusters high precision recall finally demonstrate efficacy proposed scheme using real world login events captured login servers large webmail provider hundreds millions active users
purposes study clarify relationship force tethered swimming power semi tethered swimming sts develop multiple regression models estimate force power sts using plural physical elements perform purposes force power sts elite male high school junior high school swimmers subjects measured force measured electrical digital force gauge power sts measured ergometer attachment improved bicycle ergometer furthermore height average weight finger reach span foot length vertical jump power subject measured results study summarized follows relationships force power sts relationship highly significant statistically multiple regression models estimate force derived highest correlation coefficient model theses follows xweight xage xfinger reach span xfoot length xvertical jump multiple regression models estimate power sts derived highest correlation coefficient model follows sts xheight xweight xage xfinger reach span xvertical jump xvertical jump power authors published elsevier ltd selection peer review responsibility school aerospace mechanical manufacturing engineering rmit university
nasopharynx anatomically difficult explore adequately pharyngeal bursa recess lined respiratory epitheliumalong posterior wall nasopharynx longus capitis muscles opening bursa drains nasopharynx becomes obstructed thornwaldt cyst might develop small sized cysts mostly asymptomatic whereas large sized cysts may lead various nasal otologic symptoms depending localization report present year old case huge presented clinic complaints snoring nasal obstruction periodic halitosis postnasal drip headache hearing loss left ear underwent total excision cyst transnasal endoscopy diagnosis treatment characteristics case presented review literature
real time rapid emergency control model proposed cope sudden water pollution accidents long distance water transfer projects model outputs method based pollutant properties generalized form model proposed tested demonstrative project rapid prediction formulas emergency control parameters ecps proposed different states water diversion closing times check gates pollution range calculated rapid prediction formulas ecps case study examined scenario sucrose spill demonstrative project conducted fangshui puyang channel beijing shijiazhuang emergency water supply project middle route south north water transfer project relative errors peak concentration arrival time peak concentration less however could use actual toxic soluble pollutant validate model performed experiment sucrose test model based concentration variation final result shows model able play fundamental role decisions involved emergency environmental decision support system
stress campus problem pre post pilot study assessed impact motivational interviewing via active life coaching via calc stress management full time english speaking canadian undergraduate students aged years participants assessed using perceived stress scale hospital anxiety depression scale pre mid post intervention three one way repeated measures anovas completed statistically significant differences stress reduction found pre intervention mid intervention pre intervention post intervention statistically significant differences occurred mid post intervention inductive content analysis qualitative interviews pre mid post intervention revealed participants positive experiences
used bayesian cognitive modelling identify underlying causes apparent inhibitory deficits stop signal paradigm analysis applied stop signal data reported badcock psychological medicine hughes biological psychology schizophrenia patients control participants made rapid choice responses trials signalled stop ongoing response previous research assumed inhibitory deficit schizophrenia estimates mean time taken react stop signal longer patients controls showed longer estimates partly due failing react stop signal trigger failures partly due slower initiation inhibition implicating failure attention rather deficit inhibitory process correlations probability trigger failures event related potentials reported hughes interpreted supporting attentional account inhibitory deficits results matzke report controls also display substantial although lower trigger failure rate indicate attentional factors need taken account interpreting results stop signal paradigm
based grid concept interactive hybrid online laboratory called goldi demonstrated exp ponta delgada sao miguel island azores portugal june describe new extensions infrastructure short discussion goldi remote lab infrastructure new experiment control panel ecp integrated graphical interactive finite state machine toolset gift main focus demonstration interconnection multiple remote labs based goldi infrastructure remote lab cloud within two running tempus projects ten remote labs four countries used worldwide based cloud structure necessary adapt complex goldi access control system new reservation system possibilities effective worldwide experiment management available also demonstrated
instability interpersonal relationships one central features borderline personality disorder bpd adverse conditions family environment childhood adolescence parental rejection neglect various forms abuse interfere formation maintenance secure attachment difficulties could important precursor life trajectories people bpd aim study compare group patients bpd group patients various psychopathological conditions self reported experiences childhood adolescence years negative parental care physical maltreatment emotional abuse sexual abuse witnessing domestic violence results indicate greater burden family adversity among patients bpd showed father antipathy physical sexual abuse self reported experiences greater weight predicting disorder discuss results within framework bowlby attachment theory
ecreasing energy consumption environmentally friendly energy resources issues foreground nowadays electric energy consumed illumination high long lasting low consumption led light emitting diode technology gets prominent made much reseacrh regarding use photovoltaic sytems meeting energy demand housing industry however need research regards photovoltaic sytems integration energy efficiency sytems study environments different lighting levels due daylight factor proposed low cost photovoltaics based distributed sensor smart led illuminating system acquired energy saving comparison conventional led illuminating system elsevier inc rights reserved
well often relatively stable across adulthood old age typically exhibits pronounced deteriorations vast individual differences terminal phase life however factors contributing differences well understood using year annual longitudinal data obtained deceased participants nationwide german socio economic panel study soep age death years years women explored role multi indicator constellations sociodemographic variables physical health burden factors psychosocial characteristics expanding earlier reports structural equation model sem trees allowed identify profiles variables associated differences shape late life well trajectories physical health factors found play major role well decline interaction psychosocial characteristics social participation illustrate people low social participation disability emerged strongest correlate differences late life well trajectories however people high social participation whether individual spent considerable time hospital differentiated high versus low stable versus declining late life well corroborated results variable importance measures derived set resampled sem trees called sem forests provide robust comparative indicators total interactive effects variables differential late life well discuss benefits limitations approach consider findings context reports protective factors terminal decline well
cells continuously threatened damage caused reactive oxygen nitrogen species ros rns produced physiological oxygen metabolism review summarize latest reports role oxidative stress oxidative stress induced signaling pathways etiology colorectal cancer differences ros generation may influence levels oxidized proteins lipids dna damage thus contributing higher susceptibility colon reactive species various types formed powerful oxidizing agents capable damaging dna biomolecules increased formation promote development malignancy normal rates generation may account increased risk cancer development aged review focus role oxidative stress etiology colorec tal cancer discuss free radicals free radical stimulated pathways colorectal carcinogenesis
due edge preserving ability bilateral filter considered fundamental tool computer vision computer graphics however computational complexity close connection size box window drawback leads bilateral filter inappropriate computational insensitive application one way accelerate bilateral filter approximate gaussian range kernel trigonometric functions synthesise final results set filtering results fast convolutions novel approximation applied range kernel proposed specifically first transformation range kernel obtained approximate transformation range kernel using pade approximation finally inverse transformation pade approximation obtain exponential sum approximate original range kernel coefficients exponential basis computed solving set linear equations experiments show method achieves state art results terms accuracy speed
objectives atypical antipsychotic aap class often associated metabolic disease mechanistic underpinnings risk understood due reports linking gut bacteria function metabolic disease hypothesize aap treatment adults results gut dysbiosis potentiating metabolic criteria report describes recent findings linking aap treatment differences gut microbiota communities human cohort bipolar disorder methods cross sectional design obtained ribosomal sequences patients aap treated non aap treated analysis molecular variance amova used detect significant clustering microbial communities groups inverse simpson diversity index used calculate alpha diversity detection differentially abundant operational taxonomic units otus groups performed using linear discriminant analysis effect size results aap treated cohort significantly younger increased body mass index compared non aap treated patients groups differ psychotropic medication use exception higher use benzodiazepines aap cohort detected significant separation microbiota communities aap treated nontreated patients amova aap treated females showed significant decreased species diversity compared non aap treated females males showed significant diversity treatment groups differentially abundant otus treatment groups otu otu otu classified lachnospiraceae akkermansia sutterella respectively conclusions data suggest aap treatment associated specific representation gut bacterial families aap treated patients addition aap treatment associated decreased species richness female aap treated patients
community development related approaches become prominent academic circles resulting emergence resurgence related community level notions expansion terms conceptual confusions surfaced notion community resilience gone process development understanding still progress community resilience misused confused notions including community agency community vulnerability community adaptability community capacity goal provide conceptual clarification term community resilience reviewing contrasting mentioned notions argue similitudes exist within concepts bounded literatures fed different fields study resulting different goals problem solving response change risk mitigation varying contexts despite differences offer explanations concepts interrelated addition noting differences levels conceptualization literature offers concluded community resilience provides better framework understanding community change addressed
present study designed evaluate potential role bradykinin antagonists bradykinin receptor antagonist icatibant bradykinin receptor antagonist treatment allergic airway inflammation comparison dexamethasone montelukast dexamethasone significantly decreased peribronchial leukocyte infiltration bronchoalveolar lavage fluid balf albumin interleukin beta well serum ova specific ige level also like montelukast significantly decreased balf cell count total eosinophils icatibant showed negative results current findings suggest selective bradykinin receptor antagonists may therapeutic potential treatment allergic airway inflammation elsevier rights reserved
nearest neighbors algorithm traditional algorithm utilized many research areas like computer graphics classification machine learning paper aims fixed radius nearest neighbors algorithm space neighbors searched within circular neighborhood positioned bounded space radius circle known advance uniform grids efficiently utilized nearest points query acceleration paper presents study comparing square hexagonal uniform grids suitability circular neighborhood querying two algorithms checking mutual position intersection circle square hexagon described tests show supremacy hexagonal grid
characteristics thermally forced connected vessel thermosyphon operating oscillatory mode determined using analytical techniques outcome compared results obtained numerical integration governing equations previous investigation known adequate phase plane representations limit cycles associated oscillations could obtained vessel volume ratio sufficiently small study aims demonstrating constraint vessel volumes relaxed prescribing mandelstam condition postulating total heat content system remains conserved rapid phases oscillation concluded incorporating mandelstam condition analysis highly beneficial consequence good analytical results could obtained much larger values vessel volume ratio previously permitted
plug electric vehicles one clean technologies many advantages overcome problems power systems instance voltage unbalance distribution networks considering coordinated uncoordinated charging method voltage unbalance factor improved worsened real applications pevs connected residential commercial networks form single phase charged discharged leads voltage unbalance paper effect pevs network voltage unbalance investigated form optimization problem vuf minimized objective function different conditions subject network security pevs constraints using pso algorithm vuf minimized optimally selecting state pevs charging discharging pev point connection phase charging discharging rating power also impact uncoordinated coordinated charging pevs vuf evaluated besides effectiveness proposed framework studied based unbalanced three phase distribution network finally obtained results show coordinated charging discharging pevs significantly improve vuf value published elsevier ltd
emergence many non linear loads causes severe disturbances present power system affects power quality thereby decreasing overall efficiency important issue among power quality harmonics becomes major concern power system network survey mainly discusses causes effects harmonics electrical network also discusses various detection techniques detects analyzes presence harmonics system addition survey also discusses new technique called pan tompkins algorithm detect harmonics communication protocol cloud computing
contrary known benefits fromamoderate dietary reduction adulthood life span health maternal nutrient reduction pregnancy supposed affect developing brain probably resulting impaired brain structure function throughout life decreased fetal nutrition delivery widespread developing developed countries caused poverty natural disasters also due maternal dieting teenage pregnancy pregnancy women years age placental insufficiency multiples compromised development fetal cerebral structures already shown baboon model moderate maternal nutrient reduction present study designed follow evaluate effects moderate maternal nutrient reduction individual brain aging baboon young adulthood years human equivalent years applying novel non invasive neuroimaging aging biomarker study reveals premature brain aging years female baboon exposed fetal undernutrition effects moderate maternal nutrient reduction individual brain aging occurred absence fetal growth restriction marked maternal weight reduction birth stresses significance early nutritional conditions life long developmental programming non invasive mri biomarker allows longitudinal vivo tracking individual brain aging trajectories assess life long effects developmental environmental influences programming paradigms aiding preventive curative treatments cerebral atrophy experimental animal models humans
purpose paper aims describe creation innovative intelligent systems optimise energy efficiency manufacturing systems monitor energy consumption using ambient intelligence ami knowledge management technologies together create decision support system innovative add currently used energy management systems design methodology approach energy consumption data ecd processed within service oriented architecture based platform platform provides condition based energy consumption warning online diagnostics energy related problems support manufacturing process lines installation ramp phase continuous improvement optimisation energy efficiency systems monitor energy consumption using ami technologies together create decision support system innovative add currently used energy management systems findings systems produce improvement energy efficiency manufacturing small medium sized enterprises smes systems provide comprehensive information energy use knowledge based support research limitations implications prototype systems trialled manufacturing company produces mooring chains offshore oil gas industry energy intensive manufacturing operation paper describes case study involving energy intensive processes addressed different manufacturing concepts involved manufacture mooring chains offshore platforms system developed support online detection energy efficiency problems practical implications energy efficiency optimised assembly manufacturing processes systems produce improvement energy efficiency manufacturing smes systems provide comprehensive information energy use knowledge based support social implications research addresses two critical problems energy management industrial production technologies efficiently promptly acquire provide information online optimising energy consumption effectively use knowledge support decision making originality value research inspired need industry effective tools energy efficiency opportunities industry take energy efficiency measures mostly carried research combined ami technologies involved new uses sensors including wireless intelligent sensor networks measure environment parameters conditions well process performance behaviour aspects material flow using smart tags highly flexible manufacturing temperature distribution machines information obtained could correlated standard ecd monitor energy efficiency identify problems new approach provide effective ways collect information give new insight energy consumption within manufacturing system
plenoptic piv offers simple single camera solution volumetric velocity measurements fluid flow however due novel manner particle images acquired processed references exist aid determining resolution limits measurements manuscript provides framework determining spatial resolution plenoptic piv based camera design experimental parameters information used determine smallest length scales flows observable plenoptic piv dynamic range plenoptic piv corresponding uncertainty plenoptic piv measurements simplified plenoptic camera illustrated provide reader working knowledge method light field recorded operational considerations addressed includes derivation depth resolution terms design parameters camera simulated volume reconstructions presented validate derived limits found determining lateral resolution relatively straightforward many factors affect resolution along optical axis factors addressed suggestions proposed improving performance
background heritability studies shown considerable genetic component ischemic stroke risk however much unknown genes responsible also previous studies found association atopic dermatitis increased ischemic stroke risk objective test hypothesis flg loss function mutations known associated atopic dermatitis also associated ischemic stroke methods total individuals cases ischemic stroke copenhagen general population study copenhagen city heart study copenhagen carotid stroke study genotyped two common filaggrin mutations flg flg del results flg mutation carriers odds ratio ischemic stroke confidence interval compared non carriers risk ischemic stroke flg mutation carriers higher among individuals aged years odds ratio compared non carriers stratified smoking ischemic stroke risk primarily seen current former smokers odds ratio flg mutations associated conventional cardiovascular risk factors except slightly pack years smoked among mutation carriers associated increased risk self reported eczema odds ratio finally self reported eczema associated increased ischemic stroke risk age sex adjusted hazard ratio however association statistically significant multifactorial adjustment conclusion study individuals danish general population flg loss function mutations associated increased ischemic stroke risk however residual confounding possibility
demand electricity production consistently raising since last century future tendency grow even concerning fact renewable energy specifically wave energy considered alternative energy production however devices suitable harness renewable energy source convert electricity yet commercially competitive paper focused structural analysis wave energy converter wec numerical study several design parameters tridimensional computer aided design cad numerical models built several finite element analyses fea performed using commercial finite element code main components wec simulated assuming different materials von mises stress gradients displacement fields determined fea demonstrated regardless wec component materials low young modulus seems unsuitable application valid material yield strength since materials higher yield strength lead better structural behavior wec components developed
soluble epoxide hydrolase seh converts highly active epoxyeicosatrienoic acids eets generated cytochrome cyp epoxygenases arachidonic acid less active dihydroxyeicosatrienoic acids role eets processes potentially relevant development organisms eets could suggested potential morphogens unfortunately little known seh expression human intrauterine development iud investigated spatio temporal expression pattern seh human embryonic foetal intestines liver kidney week iud two step immunohistochemistry seh expressed whole tested period prenatal development level expression remained less estimated period iud distribution cyp epoxygenases seh intestinal epithelium nephrogenic zone kidney suggests influence eets cell proliferation differentiation consequently development intestines kidney thus alterations strict spatio temporal pattern expression cyp epoxygenases seh human prenatal development xenobiotics could harmful impact developing organisms karger basel
paper presents method enables perform creep analysis elements uncracked cross sections relying evaluation average stress strain state sense fulfill volterra integral term time interval elapsed loading prediction actual state time considered analytically derived expressions time dependent stresses strains curvatures simple gained newly proposed relation ageing coefficient constitutive law creep classical formulae strength materials method proposed mathematically tractable well accounting variation elastic modulus validity method proposed proven direct calculation time dependent parameters analysis various elements approach gives exact values time dependent stress strain state determined using age adjusted effective modulus method involving sophisticated relaxation procedure method require introduction fictitious restraining actions dramatically simplifying computation could used simple alternative approach exact analysis uncracked elements numerical examples methodology applicability structures elements also developed
myelofibrosis polycythemia vera bcr abl negative myeloproliferative neoplasms associated somatic hematopoietic stem cell mutations leading activation jak stat signaling pathogenically related share specific clinical features splenomegaly constitutional symptoms phenotype dominated effects progressive bone marrow fibrosis resulting shortened survival contrast elevated thrombosis risk due erythrocytosis primary clinical concern ruxolitinib oral jak jak inhibitor approved usa treatment patients intermediate high risk patients inadequate response intolerant hydroxyurea results two phase iii studies demonstrated ruxolitinib therapy reduced spleen volume related symptom burden improved quality life measures associated prolonged overall survival treatment benefits generally sustained continued therapy dose dependent cytopenias common generally manageable transfusions anemia dose reduction treatment interruption optimal dosing management critical maintain long term treatment benefit cessation therapy resulted rapid return symptoms baseline levels results phase iii trial showed ruxolitinib significantly effective standard therapy controlling hematocrit levels improving splenomegaly related symptoms patients ruxolitinib arm compared patients control arm experienced thromboembolic event week grade parts per thousand yen cytopenias uncommon
impact ambient light mood anxiety best exemplified seasonal affective disorder patients experience depression anxiety winter less light environment however brain mechanisms underlying light dependent changes affective state remain unclear previous work revealed increased depression like behaviors diurnal nile grass rat arvicanthis niloticus housed dim light dark dim cycle compared controls housed bright light dark bright condition depression often comorbid anxiety associated dysregulation body stress response system present study examined anxiety like behaviors well indicators hypothalamic pituitary adrenal hpa axis functioning grass rats animals housed dim showed increased anxiety like behaviors compared bright controls revealed fewer entries less time spent center open field test marbles buried marble burying test following marble burying test dim animals showed higher plasma corticosterone cort levels hippocampal fos expression although daily cort rhythm comparable bright dim groups day night variation corticotropin releasing hormone mrna expression paraventricular nucleus diminished dim animals addition glucocorticoid receptor mineralocorticoid receptor mrna expression higher hippocampus dim animals results suggest diurnal species reduced daytime illumination lead increased anxiety like behaviors altered hpa axis functioning providing insights link decreased environmental illumination negative emotion elsevier rights reserved
organic rankine cycles orcs nowadays valuable technology produce electricity low medium temperature heat sources geothermal biomass waste heat recovery applications dynamic simulations help improve flexibility operation plants guarantee better economic performance work dynamic model multi pass kettle evaporator geothermal orc power plant developed dynamics validated measured data model combines finite volume approach tube side two volume cavity shell side validate dynamic model positive negative step function heat source flow rate applied simulation model performed well cases liquid level appeared challenging quantity simulate better agreement temperature achieved increasing volume flow rate geothermal brine entire simulation measurement errors discrepancies working fluid thermal brine properties uncertainties heat transfer correlations account future entire geothermal power plant simulated suggestions improve dynamics control means simulations provided
ketamine methyl aspartate nmda receptor antagonist used anesthetic abuse therapeutic contexts recent evidence suggests ketamine may affect glutamate systems may also act receptors dopamine serotonin systems monoamine neurotransmitters play important trophic roles prenatal development hypothesized behavioral consequences prenatal exposure ketamine may moderated genotype promoter monoamine oxidase maoa gene eighty two infant rhesus monkeys identified known dates conception exposures ketamine gestation animals tested months age battery tests assessing responsiveness maternal separation recognition memory contact novel objects animals classified putative activity levels maoa genotype effects prenatal ketamine exposure seen context maoa genotype greater exposure ketamine resulted increased activity less willingness perform memory task reduced emotionality novel object contact individuals low activity genotype nearly effects ketamine result first second trimester exposure maoa genotype moderates role prenatal ketamine exposure time points gestation earlier shown past research particularly evident measures emotionality results support idea ketamine use might best considered light individuals genetic characteristics
article aims introducing first steps development validation cfd tool dedicated realistic tidal turbine farm modelling fluid solver presented details together actuator disc model used represent tidal turbines particular attention paid spatial scheme order limit numerical diffusion wakes comparisons experimental results mycek horizontal axis tidal turbine hatt presented discussed different cases averaged axial velocities averaged turbulence intensity rates compared tidal turbine diameters behind device properties tool discussed terms accuracy cpu costs applicability industrial purpose elsevier ltd rights reserved
paper novel compact high voltage test system based magnetically controlled resonant transformer mcrt proposed system used perform power frequency site voltage withstanding test first basic principle mcrt introduced next fourier analysis based equivalent magnetic electrical circuits mcrt described analysis provides design reference basic mcrt parameters addition finite element model constructed verify mcrt design finally mcrt prototype designed verify effectiveness test system compared traditional test systems proposed test system paper advantages compact structure stable secondary voltage wide reactance adjustment range
nowadays vulgarization information communication technologies reached level majority people spend lot time using software regular tasks ranging games ordinary time weather utilities sophisticated ones like retail banking applications new way life supported internet specific applications changed image people using information communication technologies world first cycle studies educational systems also addressed justification encourages development children taking consideration design develop visual explorer system relational databases used everyone intuitive easy way getting immediate results new database querying experience thus paper expose main characteristics features visual database explorer showing works used execute current data manipulation operations database
data cleaning critical part data transformation stage data warehousing extracted data relational databases usually unclean may affect critical tasks different organizations data analysis decision making current techniques data cleaning generally deal one two quality aspects techniques assume availability master data users involved data cleaning manually placing confidence scores represent correctness values data paper present uniform framework algorithms integrate data deduplication inconsistent data repairing discovering accurate values data utilize embedded density information data fix errors based data density tuples close packed together present weight model assign confidence scores based density data assignments automated user involved process consider inconsistent data terms violations respect set functional dependencies fds violations common practice present cost model data repairing based weight model experimentally verify quality scalability algorithms use synthetic real datasets
investigate availability youth relevant community pharmacy services new zealand opinions pharmacy personnel appropriateness services young people aged pharmacist pharmacy support staff pss questionnaires developed collaboratively youth advisory group yag mailed randomly selected community pharmacies response rates questionnaires pharmacists pss majority community pharmacies offer public health services relevant youth health including emergency contraception condoms smoking cessation weight management harm reduction services drug use pharmacy personnel believed services appropriate youth particularly aged pss appeared less likely pharmacists feel services appropriate community pharmacies offering increasing range youth relevant health services may therefore able improve youth healthcare access research required investigate barriers young people accessing services pharmacies also challenges pharmacy personnel providing services age group
connection wireless sensor actuator networks wsans internet enable information flow isolated networks distributed ambient intelligence ami applications remote monitoring control services would become possible internet connectivity wsans achieved however realization applications remains challenging three major obstacles first homogeneity embedded sensor actuator nodes hence homogeneous networks prevents seamless information flow service provision second current wsan technology limited support internet connectivity protocol conversion heavy overhead required powerful gateway device third common interoperable interfaces different wsan standards become barrier heterogeneous wsan applications paper introduces design integrated compatible heterogeneous wsan composed university auckland awsam oracle sunspot nodes achieved creation hybrid router physically bridges awsam sunspot communication customized network abstraction edge router provides internet connectivity
youth parent rated screening measures derived strengths difficulties questionnaire sdq development well assessment dawba compared psychometric properties predictors caseness adolescence mean age successful screening judged firstly likelihood icd psychiatric diagnosis secondly ability discriminate community clinical samples sample status sdq dawba measures adequately predicted presence icd disorder well sample status hypothesis informant gradient confirmed youth self reports less discriminating parent reports whereas combined parent youth reports discriminating finding replicated across diversity measures practical constraints permit screening caseness using either parent adolescent informant parents better source information
virtual reality used visually substitute person body life sized virtual one embodiment results perceptual illusion body ownership virtual body previous research shown form influence implicit attitudes particular embodying white people black virtual body associated immediate decrease implicit racial bias black people tested whether reduction implicit bias lasts least week whether enhanced multiple exposures two experiments carried total female participants virtual body either black white participants required follow virtual tai chi teacher either asian european caucasian participant exposures separated days implicit racial bias measured week first exposure week last results show implicit bias decreased black virtual body white also evidence general decrease bias independently body type possible explanations put forward
meminductor new type memory device importance study meminductor model application nonlinear circuit prospectively purpose present novel mathematical model meminductor considers effects internal state variable therefore consistent future actual meminductor device using several operational amplifiers multipliers capacitors resistors equivalent circuit model designed exploring characteristics equivalent circuit employed design meminductor based application circuits meminductor emulator employing simulation experiment investigate characteristics meminductor driven sinusoidal excitation characteristic curves current flux phi voltage flux phi rho internal variable meminductor phi rho meminductor model given theoretical analyses simulations curve current flux phi pinched hysteretic loop passing origin area bounding sub loop deforms frequency varies increase frequency shape pinched hysteretic loop tends straight line indicating dependence frequency meminductor based meminductor model meminductive wien bridge chaotic oscillator designed analyzed dynamical properties including equilibrium points stability bifurcation lyapunov exponent oscillator investigated detail theoretical analyses simulations utilizing lyapunov spectrum bifurcation diagram dynamical map found system periodic quasi periodic chaotic states furthermore exist complicated nonlinear phenomena system constant lyapunov exponent spectrum nonlinear amplitude modulation chaotic signals moreover also find nonlinear phenomena coexisting bifurcation coexisting attractors including coexistence two different chaotic attractors coexistence two different periodic attractors phenomenon shows state oscilator highly sensitive initial valuse chaotic state also periodic state called coexistent oscillation paper basic mechanism potential applications existing attractors illustrated used generate robust pseudo random sequence multiplexed pseudo random sequence finally using equivalent circuit proposed meminducive model realize analog electronic circuit meminductive wien bridge chaotic system results circuit experiment displayed oscilloscope verify chaotic characteristics oscillator oscillator pseudo random signal source used generate chaotic signals applications chaotic cryptography secret communications
representation women called mainstream media well studied however less known representation ethnic media especially north america ethnic media sector constantly growing ethnic media unique news sourcing strategy mix news locally produced local staff writers news outsourced local mainstream media news internationally imported country origin suggests underrepresentation women mainstream media spill reproduced ethnic media content analysis korean news media vancouver los angeles finds interesting interplay transnational effect local effect pervasive influence mainstream media country origin evident transnational effect strong female leadership local community active roles leaders news sources actors contribute positively overall representation women local effect
multiple instance learning mil framework wherein training examples provided form labeled bags rather labeled instances visual object tracking mil framework used select discriminative features pool features maximizing bag likelihood feature pool consists computationally efficient haar like features feature used construction weak classifier also called decision stump classifiers high discriminative power separate target background combined form strong classifier key point selection highly discriminative features large pool small amount time ensure fast accurate tracking paper propose fast online feature selection algorithm based maximizing classifier score csr tracking performance better existing feature selection methods paper also introduces kernel trick haar like features target tracking furthermore explore use haar features half target space get actual target size successive video frames scaling strategy applied feature matching using kernel haar features half target spaces scale adaptation method single tracking framework obtain better tracking performance compared state art trackers
despite increasing levels pollution many tropical african countries much known strength weaknesses policy institutional frameworks tackle pollution ecological status rivers impacts biota investigated ecological status four large river basins using physicochemical water quality parameters bioindicators collecting samples forest agriculture urban landscapes nile omo gibe tekeze awash river basins ethiopia also assessed water policy scenario evaluate appropriateness prevent control pollution investigate level understanding implementation regulatory frameworks policies related water resources reviewed policy documents conducted depth interviews stakeholders physicochemical biological data revealed significant water quality deterioration impacted sites agriculture coffee processing urban landscapes compared reference sites forested landscapes four basins analysis legal policy institutional framework showed lack cooperation stakeholders lack knowledge policy documents absence enforcement strategies unavailability appropriate working guidelines disconnected institutional setup grass root level implement set strategies major problems conclusion river water pollution growing challenge needs urgent action implement intersectoral collaboration water resource management eventually lead toward integrated watershed management revision policy increasing awareness participation implementers vital improve ecological quality rivers
lyapunov functions essential tool stability analysis dynamical systems theory applications provide sufficient conditions stability equilibria general invariant sets well basin attraction necessity existence lyapunov functions studied converse theorems however provide general method compute importance stability analysis numerous computational construction methods developed within engineering informatics mathematics community cover different types systems ordinary differential equations switched systems non smooth systems discrete time systems etc employ different methods series expansion linear programming linear matrix inequalities collocation methods algebraic methods set theoretic methods many others review brings different methods together first different types systems lyapunov functions used briefly discussed main part computational methods presented ordered type method used construct lyapunov function
authors present comprehensive overview image processing analysis work done support research model flowering plant arabidopsis thaliana beside plant importance biological research using image analysis obtain experimental measurements interesting vision problem right involving segmentation analysis sequences images objects whose shape varies individual specimens also changes time useful measurements obtained segmenting whole plant background suggest increased range precision measurements made available leaf level segmentation makes problem well worth solving variety approaches tried biologists well computer vision researchers interdisciplinary area computer vision community important contribution make suggest need publicly available datasets ground truth annotations enable evaluation new approaches support building training data modern data driven computer vision approaches likely result kind fully automated systems use biologists
allogeneic hematopoietic cell transplantation allo hct remains curative treatment option myelofibrosis despite emergence novel targeted therapies reduce graft rejection graft versus host disease gvhd current allo hct protocols often include vivo lymphocyte depletion using polyclonal anti thymocyte globulin atg shortly atg administration immediate inflammatory response fever chills laboratory alterations cytopenias elevation serum reactive protein bilirubin transaminases develop explore whether patients commonly exhibit extramedullary hematopoiesis liver might particularly susceptible atg induced liver toxicity test hypothesis analyzed control patients three transplant centers treated without atg allo hct conditioning regimen indeed hyperbilirubinemia found nearly every patient treated atg atg compared non atg treated noatg respectively atg treated non patients control group control atg contrast transaminases inconsistently elevated hyperbilirubinemia cases self limiting predictive increased incidence non relapse mortality hepatic sinusoidal obstruction syndrome sos liver gvhd sum awareness stereotypic bilirubin elevation patients treated atg provides relatively benign explanation hyperbilirubinemia occurring patients early transplant however attention drug levels biliary excreted drugs warranted since altered bile flow may influence clearance enhance toxicity busulfan antifungal agents
virtual reality started years ago form would recognize today stereo head mounted display hmd head tracking computer graphics generated images although hardware completely different emerged based different generation hardware crt displays rather vector refresh electromagnetic tracking instead mechanical reached attention public hailed many engineers scientists celebrities business people beginning new era would soon change world better disappeared public view rumored dead intervening years huge amount research nevertheless carried across vast range applications medicine business psychotherapy industry sports travel scientists engineers people working industry carried research applications using exploring different forms knowing actually topic already passed away purpose article survey range applications evidence least debate utility mainly based publications peer reviewed journals course every type application covered every scientific paper papers google scholar particular review covered applications psychological medical rehabilitation objective reader becomes aware accomplished evidence weaker stronger done start section outline major conceptual framework used understand happens people experience concept presence section review areas used science mostly psychology neuroscience area scientific visualization remarks use education surgical training section discuss used sports exercise section survey applications social psychology related areas used throw light social phenomena used tackle experimentally areas studied experimentally real life conclude used preservation access cultural heritage section present domain moral behavior including example might used train professionals medical doctors confronting serious dilemmas patients section consider might used various aspects travel collaboration industry section consider mainly use news presentation also discuss different types concluding section briefly consider new ideas recently emerged impossible task since short time written page even newer ideas emerged conclude general considerations speculations throughout wherever possible stressed novel applications approaches real power necessarily produce faithful reproduction reality rather offers possibility step outside normal bounds reality realize goals totally new unexpected way hope article provoke readers think paradigm changers advance realize different worlds might positive impact lives millions people worldwide maybe even help little saving planet
year old lady presented history occasional severe abdominal cramps postprandial diarrhoea weight loss routine gastrointestinal investigations diagnosed irritable bowel syndrome six months developed occasional facial flushing prompting assessment neuroendocrine tumour markers urinary hiaa chromogranin neurokinin significantly elevated scans showed extensive hepatic metastases show location primary tumour somatostatin analogue therapy commenced despite increasing doses symptoms increased biomarkers rose dramatically interferon alpha introduced concomitant somatostatin analogue therapy biomarkers monitored regularly within six months symptoms abated biomarkers reduced continuing fall next year close reference range manage side effects interferon alpha dose reduced time time short periods neurokinin showed significant transient increases carcinoid symptoms returned seven years operation patient balance achieved interferon alpha side effects disease control scans showed tumour load stable patient survived years post diagnosis chose discontinue interferon alpha received peptide receptor radiation therapy final year throughout neurokinin remained sensitive monitor disease progression
recent years challenges environmental issues sustainable alternatives fossil fuels increasing energy demand decreasing profitability fossil fuels extracted readily available reservoirs shale formations tight sands unsteady unpredictable energy prices forced oil producing countries turn attention renewable energies countries located world solar belt excellent solar availability average days bright sunshine throughout year result growing attention solar energy especially photovoltaics pvs therefore tremendous progress witnessed technology well economy blooming new markets past decades considerable progress application pvs oil producing countries closely dependent upon development suitable policies strategies due existence high electricity subsidies low tariffs governments context paper aims pursue current progress pvs major oil producing countries located around persian gulf discuss recent advances prospective policy iran case study obtained results show minimum increase annual electricity rate would guarantee benefit investments pvs power plants current economic situation iran subsequently study investigates optimal approaches development application pvs oil producing countries
professionally run centres created number countries past decades provide place parents young children meet provide children play opportunities social contacts peers also intended tackle potential negative consequences mother child isolation modern societies providing mothers social support many mothers find participation centres supportive study uses ethnographic observations mothers social experience centres france italy japan aim better understanding potential beneficial effects attending centres beyond organizational cultural differences centres across countries joint analysis observations highlighted important similarities social processes occurring among mothers centres supported hypothesis positive social experiences basic potential source psychological benefits centres provide mothers
background dbs surgical method choice various movement disorders especially parkihson disease many publications showing improvement motor symptoms quality life presented little comprehensive research evaluation impact dbs mental state psychiatric side effects object purpose study assess impact dbs mood drive anhedonia psychotic symptoms group patients methods patients treated stn dbs mental state psychiatric side effects assessed use madrs hadrs bdi bprs yms shads cgi pgi rating scales evaluation performed five times period day surgery six months implantation dbs results study showed improvement mood followed within month start stimulation manifested madrs hadrs bdi scores reduction trend towards improvement maintained following months manic episodes appeared cases mild hypomania observed psychotic symptoms occurred patient anhedonia reduction observed first days initiating stimulation persisted assessment six months implantation dbs conclusions survey results confirm effect stimulation mood drive ability feel pleasure psychiatric side effects phase change rare mild psychotic symptoms occurred one patient ware manageable medication intensive research topic required elsevier rights reserved
despite object thriving field clinical research investigation intrinsic brain network alterations psychiatric illnesses still early days pathological alterations predominantly probed using functional magnetic resonance imaging fmri many questions electrophysiological bases resting state alterations psychiatric disorders particularly among mood disorder patients remain unanswered alongside important research using electroencephalography eeg specific recent contributions future promise magnetoencephalography meg field fully recognized valued provide critical review recent findings meg resting state connectivity within major depressive disorder mdd bipolar disorder clinical meg resting state results compared previously reported fmri eeg taken together meg appears promising still critically underexploited technique unravel neurophysiological mechanisms mediate abnormal hyper hypo connectivity patterns involved mdd particular major strength meg ability provide source space estimations neuromagnetic long range rhythmic synchronization various frequencies oscillatory coupling reviewed literature highlights relevance probing local interregional rhythmic synchronization explore pathophysiological underpinnings disorder however fully take advantage meg connectivity analyses psychiatry several limitations inherent meg connectivity analyses need understood taken account thus also discuss current methodological challenges outline paths future research meg resting state studies provide important window onto perturbed spontaneous oscillatory brain networks hence supply important complement fmri based resting state measurements psychiatric populations
schizophyllan biopolymer used skin care product immunity enhancement agent short communication studies rheology schizophyllan solution high salinity high temperature experiments show schizophyllan maintains high viscosity high salinity loss viscosity insignificant high temperature degrees impressive stability schizophyllan high temperature high salinity renders potential enhance oil recovery oil gas industry field pilot carried since field results indicate injection schizophyllan solution oil strata leads improved oil production
sequential pattern mining spm important data mining problem broad applications spm hard problem due huge number intermediate subsequences considered state art approaches spm prefixspan pei largely based pattern growth approach frequent prefix subsequence related suffix subsequences need considered database recursively projected smaller ones many authors promoted use constraints focus promising patterns according interests end user top spm problem also used cope difficulty thresholding control number solutions state art methods developed spm top spm though efficient locked rather rigid search strategy suffer lack declarativity flexibility indeed adding new constraints usually amounts changing data structures used core algorithm combining new constraints often require new developments recent works kemmar grevergne guns investigated use constraint programming spm however despite nice declarative aspects modelings scaling problems due huge size constraint networks address issue propose prefix projection global constraint encapsulates subsequence relation well frequency constraint filtering algorithm relies principle projected databases allows keep variables domain values leading frequent pattern database prefix projection filtering algorithm enforces domain consistency variable succeeding current frequent prefix polynomial time global constraint also allows straightforward implementation additional constraints size item membership regular expressions combination experimental results show approach clearly outperforms existing approaches competes well state art methods large datasets mining frequent sequential patterns sequential patterns various constraints top sequential patterns unlike existing methods approach achieves better scalability
use delayed coefficient adaptation least mean square lms algorithm enabled design pipelined architectures real time transversal adaptive filtering however convergence speed delayed lms dlms algorithm compared standard lms algorithm degraded worsens increase adaptation delay existing pipelined dlms architectures large adaptation delay hence degraded convergence speed paper first present pipelined dlms architecture minimal adaptation delay given sampling rate architecture synthesized using number function preserving transformations signal flow graph representation dlms algorithm use carry save arithmetic pipelined architecture support high sampling rates limited delay full adder multiplexer second part paper extend synthesis methodology described first part synthesize pipelined dlms architectures whose power dissipation meets specified budget low power architecture exploits parallelism dlms algorithm meet required computational throughput architecture exhibits novel tradeoff algorithmic performance convergence speed power dissipation elsevier science rights resented
urban water systems throughout world recurring increasing water scarcity given demand growth aging infrastructure variability uncertainty imposed climate change rainwater harvesting systems rwhs represent promising alternative increase flexibility robustness water supply systems given importance tank size establishing reliable rwhs propose implicit stochastic approach assess performance aid designers main objective study simulate common non potable water demand roof area typologies verify demand roof area affect efficiency rwhs highlight usefulness model aid definition tank sizes also performed economic assessment results specific study region climate might vary different climate however chosen rather unfavourable climate poor rainfall distribution along year conditions results likely closer lower bound benefits indicates potential water savings benefits rwhs even unfavourable scenarios rwhs indicated efficient meeting demands smaller demand roof area ratios furthermore possible determine efficiency rwhs various scenarios identifying minimum maximum likely benefits several scenarios compared directly allowing establishment general maximum tank size per unit roof area given region interest beyond significant benefits likely economic assessment indicates positive net present values investing rwhs especially large rooftop areas small demand roof area ratios conditions investing rwhs low risk likely short payback times elsevier ltd rights reserved
thermoresponsive polymers subject numerous publications research topics last decades mostly driven easily controllable temperature stimulus high potential vitro vivo applications nipaam studied amongst polymers recently types polymers increasingly investigated thermoresponsive behavior particular polymers bearing short oligo ethylene glycol oeg side chain shown combine biocompatibility polyethylene glycol peg versatile controllable lcst behavior polymers synthesized via controlled radical polymerization techniques various monomers consisting oeg chain polymerizable group like meth acrylate styrene acrylamide oeg acrylates offer significant advantages oeg methacrylates lower hydrophilicity backbone facilitates thermoresponsive behavior smaller defined side chains furthermore peg acrylates polymerized using major controlled radical polymerization techniques unlike oeg methacrylates review focus oeg acrylate based polymers provide comprehensive overview reported thermoresponsive properties combination comparison data highlight potential monomers also serve starting point future studies elsevier ltd rights reserved
objectives type diabetes chronic condition affects nearly three million canadians including immigrants timing first onset diabetes linked several severe diseases yet dearth empirical studies examine timing first onset diabetes among canadians general among immigrants ethnic minority populations within canada particular design applying event history techniques canadian community health survey address research void examining factors contribute first onset diabetes among immigrant visible minority populations canada given gendered patterns epidemiology diseases differences risk factors men women gender specific models estimated results results showed south asian black filipino women developed diabetes earlier compared women similarly south asian chinese filipino black south east asian arab men developed diabetes earlier men significant important finding analysis risks developing diabetes vanished completely black filipino women accounting lifestyle factors south asian women however significant attenuation risks accounting lifestyle factors findings strikingly different immigrant men specifically risks developing diabetes increased accounting lifestyle factors conclusions results suggest development gender specific lifestyle interventions targeted specific immigrant groups increased risks developing diabetes earlier life course
recent resting state functional magnetic resonance imaging fmri studies provided strong evidence abnormal spontaneous brain activity amnestic mild cognitive impairment amci however conclusions inconsistent meta analysis whole brain fmri studies measured differences amplitude low frequency fluctuations alff amci patients healthy controls conducted using seed based mapping software package twelve studies reporting datasets included meta analysis compared healthy controls patients amci showed decreased alffs bilateral precuneus posterior cingulate cortices bilateral frontoinsular cortices left occipitotemporal cortex right supramarginal gyrus increased alffs right lingual gyrus left middle occipital gyrus left hippocampus left inferior temporal gyrus meta regression analysis demonstrated increased severity cognitive impairment amci patients associated greater decreases alffs cuneus precuneus cortices comprehensive meta analysis suggests amci associated widespread aberrant regional spontaneous brain activity predominantly involving default mode salience visual networks contributes understanding pathophysiology elsevier rights reserved
study aimed investigate functional developmental outcomes school age children diagnosed global developmental delay years old verify association final diagnosis environmental biological factors forty five brazilian children boys mean age months attended regular school diagnosed global developmental delay years old functions evaluated children global developmental delay diagnosed several conditions school age students greater chances receiving diagnosis whose mothers younger time children born impaired motor performance specially balance needed help cognitive behavioral tasks school interdisciplinary evaluation contributed defining specific diagnosis identifying necessity specialized support
human skin barrier important role protection defense reflected ability resist entry harmful substances human body also ability prevent loss water nutrients skin barrier damaged skin may become dry scaly wrinkled series skin problems may occur article review composition lipids ceramides cholesterol free fatty acids skin examine expression enzymes related lipid metabolism kallikreins elongase elongation long chain fatty acids hydrolases lipid synthases additionally discuss involvement proteins skin barrier function structure information presented review expected provide theoretical basis development skin care products facilitating maintenance repair skin barrier function
plasma numerical library intended successor lapack solving problems dense linear algebra multicore processors plasma relies quark scheduler efficient multithreading algorithms expressed serial fashion quark superscalar scheduler implements automatic parallelization tracking data dependencies resolving data hazards runtime recently type scheduling incorporated openmp standard allows transition plasma proprietary solution offered quark standard solution offered openmp article studies feasibility transition
objective case oral metastatic follicular thyroid carcinoma presented background metastatic tumours frequent older individuals sign symptom undiagnosed primary malignancy case report year old lady presented enlarging mandibular swelling incisional biopsy imaging studies suggestive metastatic follicular thyroid carcinoma conclusion metastatic tumours considered differential diagnosis mandibular swellings especially older individuals
expected rooftop photovoltaic systems realize net zero energy solar buildings nzesbs enough realize nzesbs smart photovoltaic system blind spsb proposed generate electricity system reduce indoor cooling demands shading effect blind system implementation study aims investigate impact proposed spsb nzesbs conducted three ways technical economic political analyses detailed results summarized follows technical analysis applying spsbcigs axis represents spsb copper indium gallium selenide cigs panel two axis tracking system energy self sufficiency rate determined times superior alternatives economic analysis terms npv net present value year spsbcigs axis determined times superior others terms sir savings investment ratio year times terms break even point years iii political analysis grid connected utilization plan including solar renewable energy certificates incl srec plan determined improve economic profitability proposed spsb elsevier ltd rights reserved
psychological perspective taking powerful social cognition helps understand people creates feelings closeness sympathy motivates help others important positive social relationships contrast impressive knowledge consequences relatively little known exactly people achieve present paper addresses question grounded cognition perspective drawing recent findings embodiment visuospatial perspective taking visuospatial perspective taking involves mental transformation one body schema physical location another person argue people psychologically put another person shoes simulation physical proximity happens one source perceived closeness five experiments total participants completed visuospatial perspective taking task half trials angular disparity target person participant high participants adopt target visual perspective involves embodied simulation remaining trials angular disparity low participants could solve task egocentrically taking another perspective led participants adopt thoughts target person strongly experiments increased perceived similarity person self experiment participants liking person experiment effects independent task difficulty experiment present trials embodied transformation happened high angular disparities experiment implications psychological visuospatial perspective taking research related phenomena discussed
neural circuits develop abnormally due different genetic deficits environmental insults neural computations behaviors rely altered computational theories relate neural circuits specific quantifiable behavioral physiological phenomena therefore serve extremely useful tools elucidating neuropathological mechanisms underlie different disorders visual system particularly well suited characterizing differences neural computations computational theories vision well established empirical protocols measuring parameters theories well developed article examine psychophysical neuroimaging measurements human subjects used test hypotheses abnormal neural computations autism emphasis hypotheses regarding potential excitation inhibition imbalances discuss complexity relating specific computational abnormalities particular underlying mechanisms given diversity neural circuits generate computation discuss areas research computational theories need developed provide useful frameworks interpreting existing results final emphasis placed need extend existing ideas developmental frameworks take account dramatic developmental changes neurophysiology changes excitation inhibition balance take place first years life autism initially emerges
tobacco consumption become major public health issue motivated studies identify understand biological processes involved smoking behavior prevention smoking cessation treatments cypa identified main gene codifies enzyme metabolizes nicotine many alleles identified discovery cypa suggesting wide interethnic variability diverse smoking behavior allele carrying individuals main purpose review update highlight effects cypa gene variability related tobacco consumption reported diverse human populations review aims consider cypa future studies possible genetic marker prevention treatment nicotine addiction therefore analyzed several population studies importance addressing characterizing population using specific parameters efforts may contribute personalized system detecting preventing treating populations higher risk smoking avoid diseases related tobacco consumption
individual differences social anxiety extraversion shown influence education outcomes however limited investigation relationship individual differences attitudes towards online offline learning study aimed investigate first time social anxiety extraversion influence student attitudes online offline learning specifically relation tertiary level practical activities based social compensation hypothesis predicted students higher levels extraversion lower levels social anxiety would report favourable attitudes face face learning activities predicted less extraverted socially anxious students would favourable attitudes online learning activities undergraduate students female completed hexaco personality inventory mini social phobia inventory measures attitudes towards online offline activities two hierarchical multiple regressions conducted first revealed neither extraversion social anxiety contributed significantly preference online practical activities second regression revealed greater emotionality greater extraversion greater conscientiousness lower levels social anxiety associated favourable attitudes towards face face practical activities contrast predictions extraversion social anxiety significantly contribute attitudes online learning activities however line predictions greater extraversion lower levels social anxiety associated favourable attitudes towards face face practical activities findings indicate online learning activities limited compensatory effects students experience social discomfort social compensation hypothesis may apply within educational framework unexpected ways elsevier ltd rights reserved
new design method multilayer composite glass absorbing thin film presented composite glass high microwave reflective factor good transparency visible light region useful vehicle stealth technology microwave protection large capacity microwave transmission system
stream restoration efforts united states increasingly aimed towards water quality improvement yet little process based guidance exists compare pollutant removals different restoration techniques variable site conditions excess nitrate frequent pollutant concern due eutrophication downstream waterbodies chesapeake bay used mike simulate hydraulics removal restored reach stroubles creek second order stream blacks burg virginia site specific geomorphic hydrologic hydraulic data used calibrate model evaluated stream structures induce hyporheic zone denitrification baseflow inset floodplains remove storm flows varied hydraulic conditions winter baseflow summer baseflow storm flow biogeochemical parameters literature hyporheic zone denitrification rates newly available inset floodplain removal rates boundary conditions upstream concentration sediment conditions hydraulic conductivity stream restoration design parameters inset floodplain length results indicate removal rates within reach minimal structure induced hyporheic zone denitrification exceed mass flowing upstream channel achieved favorable background groundwater hydraulic conditions summer baseflow transport limited non trivial removal rates achieved streambed hydraulic conductivity least inset floodplain nitrogen removal limited floodplain residence time removal rate exceed inflowing mass summing removals restoration practices course year based frequency storm summer baseflow conditions yielded similar annual removal achieving removal required increasing length stream reach restored depending hydraulic conductivity depending inset floodplain length nitrogen removal rate stream structures baseflow inset floodplains storm flow respectively one first comparisons process based modeling chesapeake bay program stream restoration guidance found guidance overestimated hyporheic removal modeled reach correctly estimated inset floodplain removal overall results indicate stream structures inset floodplains improve water quality overall required level effort may high achieve desired results elsevier rights reserved
sub multimodal analog front end ultralow energy biosensing cmos soc presented photoplethysmography ppg signal chain consumes five times lower power state art demonstrated snr dbfs achieved using circuit system techniques enable sub analog duty cycling input signal aware fly real time data path adaptation algorithms implemented external microcontroller synchronized ultralow power chip fsm along ksps sar adc lower system energy programmable asynchronous reset capacitive amplifier parca noise efficiency factor nef analog feature extractor demonstrates energy efficient electrocardiogram ecg capture wearable platform using soc simultaneously captures ecg plus ppg wirelessly transmits heart rate using bluetooth low energy every smartphone lasts greater five days mahr battery
understanding hydraulics around injection production wells unconfined aquifers associated rainwater reclaimed water aquifer storage schemes issue increasing importance much work done previously understand mathematics associated darcy law context however groundwater flow velocities around injection production wells likely sufficiently large induce significant non darcy effects article presents mathematical analysis look forchheimer equation context water injection water production unconfined aquifers three different approximate solutions derived using quasi steady state assumptions method matched asymptotic expansion resulting approximate solutions shown accurate wide range practical scenarios comparison finite difference solution full problem concern approximate solutions led improved understanding flow dynamics also used verification tools future numerical models context elsevier rights reserved
inflammatory bowel disease ibd includes crohn disease ulcerative colitis chronic idiopathic inflammatory disorder affecting gastrointestinal tract extraintestinal manifestations eims common patients ibd occur patients eims involve organs gastrointestinal tract skin eyes joints biliary tract kidneys renal urinary involvement particularly occurs patients ibd among renal complications ibd secondary amyloidosis type aaa rare serious complication renal amyloidosis proven common lethal manifestation ibd associated amyloidosis since renal involvement rapidly leads end stage renal failure studies suggest aaa prevalent mainly occurring male patients extensive long lasting penetrating disease pattern therapeutic approaches ibd associated aaa based control chronic inflammatory process causes production storage serum amyloid saa precursor amyloid well destabilizing amyloid fibrils longer maintain beta pleated sheet configuration however patients end stage renal disease therapeutic options still available hemodyalisis renal transplantation whether effective treatment exists aaa remains controversial
objective study aimed validating photoplethysmography assessing bilateral blood pressure differences investigating correlations digital volume pulse arteriosclerosis risk methods totally subjects healthy diabetic recruited demographic blood pressure anthropometric data recorded blood collected determining serum cholesterol total triglyceride total cholesterol high low density lipoprotein cholesterol fasting blood sugar glycated haemoglobin concentrations arterial stiffness assessed electrocardiogram based pulse wave velocity crest time inter digital volume pulse differences results receiver operating characteristic curve demonstrated high inter digital volume pulse difference sensitivity glycated haemoglobin level linear regression analysis demonstrated significant correlation inter digital volume pulse difference electrocardiogram based pulse wave velocity compared electrocardiogram based pulse wave velocity inter digital volume pulse difference exhibited highly significant correlations age glycated haemoglobin level pulse pressure total cholesterol high density lipoprotein ratio crest time high density lipoprotein systolic blood pressure conclusion conclusion results demonstrated successful application novel non invasive waveform contour index inter digital volume pulse difference differentiating young aged subjects patients good diabetic control poor diabetic control also validated use identifying arteriosclerosis risks results therefore endorse domestic application non invasive tool arteriosclerosis risk screening
according theoretical approaches influence presumed media influence approach individuals attitudes behaviors affected influences believe media others politicians example thought perform media relations activities ascribe great importance media tested regarding politicians online activities using data two surveys members germany national parliament bundestag hypothesized parliamentarians use facebook twitter extensively believe social media tools strong political influence public journalists politicians however results indicate parliamentarians use facebook twitter regardless whether expect impact people therefore politicians online activities determined reasons strategic motives thus although precisely hypotheses rejected findings important contribution research politicians motives online communication
modern radio telescopes favouring densely packed array layouts large numbers antennas greater similar since complexity traditional correlators scales steep cost realizing full imaging potential powerful instruments generic efficient field parallel imaging correlator epic present first software demonstration generalized direct imaging algorithm namely modular optimal frequency fourier imager bring cost dense layouts log also image irregular layouts heterogeneous arrays antennas epic highly modular parallelizable implemented object oriented python publicly available verified images produced equivalent traditional techniques within precision set gridding coarseness also validated implementation data observed long wavelength array lwa provide detailed framework imaging heterogeneous arrays show epic robustly estimates input sky model arrays antenna layouts dense filling factors consisting large number antennas lwa square kilometre array hydrogen epoch reionization array canadian hydrogen intensity mapping experiment gain significant computational advantage deploying optimized version epic algorithm strong candidate instruments targeting transient searches fast radio bursts well planetary exoplanetary phenomena due availability high speed calibrated time domain images low output bandwidth relative visibility based systems
contrast prenatal development cerebral cortex cell production migration layer formation dominate development birth involves subtle processes activity dependent plasticity includes refinement synaptic connectivity stabilization elimination present study use rna seq high spatial resolution examine differential gene expression across layers mouse visual cortex onset critical period plasticity postnatal day peak mature stage compare prefrontal association area find although genes involved early developmental events cell division neuronal migration axon guidance still prominent expression largely terminates synaptic plasticity associated signaling pathways become enriched unexpectedly gene expression profile similar areas age suggesting activity dependent plasticity visual association cortices subject genetic constraints although gene expression changes follow similar paths identified regionally enriched genes prominent critical period identified several hundred differentially expressed gene isoforms despite subsiding levels gene expression differences result indicates genetic developmental programs cease remaining morphogenetic processes may depend posttranslational events
introduction distress intolerance implicated various aspects smoking maintenance quit behavior although past work conducted almost exclusively among european american samples method present study sought extend past work exploring distinct subdimensions distress tolerance tolerance appraisal regulation absorption among sample female mag adult daily smokers mexico city mexico regard multiple indices problematic smoking results results indicated appraisal dimension distress intolerance associated smoking cigarettes per day greater number lifetime failed quit attempts increased likelihood early smoking relapse findings remained significant controlling negative affectivity gender alcohol usage well variance accounted distress tolerance dimensions conclusions results provide novel preliminary empirical evidence lesser perceived ability tolerate distress appraised unacceptable may particularly important element construct terms better understanding multiple public health relevant indicators smoking mexican smokers overall present findings uniquely contribute growing body research related distress intolerance implications explicating nature maintenance smoking behavior among highly understudied segment smoking population mexican smokers elsevier ltd rights reserved
recent attention communities localizing food systems increased need understand perspectives people working foster collaboration eventual transformation food system university cooperative extension educators ees increasingly play critical role communities food systems across united states providing various resources address local needs better understanding ees perspectives food systems therefore important inspired work stevenson ruhf lezberg clancy social food movement conducted national virtual focus groups examine ees attitudes food system change happen reasons resources power influence effect change institutions within ees embedded shape perceptions available resources community including authority power holds resources turn structure ees goals strategies food system change find ees envision working within current food system building market centric alternatives address inequity vulnerable consumers producers ees bring many resources table believe influence authority change policy findings could suggest ees limited ability transformative change agents ees potentially connect efforts new partners share perceptions food system problems solutions ees increasingly engage food system work increasingly diverse stakeholders access alternative transformational frames within set goals organize work
investigate implication problems keys independence atoms relational databases keys unary independence atoms show finite implication finitely axiomatizable establish finite axiomatization general implication axiomatization also sound complete finite general implication unary keys independence atoms coincide show general implication keys unary independence atoms unary keys general independence atoms decidable polynomial time two classes also show construct armstrong relations finally establish tractable conditions sufficient certain classes keys independence atoms interact elsevier inc rights reserved
article presents experiment seniors people visual impairment voice controlled smart home using sweet home system experiment shows weaknesses automatic speech recognition must addressed well need better adaptation user environment users disturbed rigid structure grammar eager adapt preferences surprisingly humanoid aspect introduced system senior participants inclined embody system despite aspects improve system favorably assessed diminishing participant fears related loss autonomy
mobile application supported multiple major platforms market penetration maximized cross platform native applications essentially deliver core functionality albeit within conventions supported platform maintaining evolving cross platform native application tedious error prone modification requires replicating changes application platform specific variants syntax directed source source translation proves inadequate alleviate problem native api access always domain specific paper present novel approach native native uses program transformations performed one platform automatically synthesize equivalent code blocks used another platform programmer modifies source version application changes captured based changes native native identifies semantic content source code block formulates appropriate query search equivalent target code block using popular web based programming resources discovered target code block presented programmer automatically synthesized target language source file fine tuning subsequent integration mobile application target version evaluate proposed method using common native resources sensors network access canonical data structures show approach correctly synthesize ios code provided android source code android code provided ios source code presented approach effectively automates process extracting source code block semantics discovering existing target examples equivalent functionality thus alleviating laborious intellectually tiresome programming tasks modern mobile development published elsevier ltd
software product line set software systems domain share common features also significant variability feature model variability modeling artifact represents differences among software products respect variability relationships among features feature model along reference model developed domain engineering lifecycle concrete product family derived selecting features feature model referred configuration process instantiating reference model however feature model configuration cumbersome task feature models may consist large number features hard comprehend maintain many factors including technical limitations implementation costs stakeholders requirements expectations must considered configuration process recognizing issues significant amount research efforts dedicated different aspects feature model configuration automating configuration process several approaches proposed alleviate feature model configuration challenges applying visualization interaction techniques however limited empirical insights available impact visualization interaction techniques feature model configuration process paper present set visualization interaction interventions representing configuring feature models empirically validated measure impact proposed interventions empirical study conducted following principles control experiments software engineering applying well known software quality standard iso operationalize variables investigated experiment results empirical study revealed employed visualization interaction interventions significantly improved completion time comprehension changing feature model configuration additionally according results proposed interventions easy use easy learn participants
primary ovarian insufficiency poi characterized loss ovarian function age account one major cause female infertility poi relevance continuously growing increasing number women desiring conception beyond years age poi prevalence poi highly heterogeneous present ovarian dysgenesis primary amenorrhea secondary amenorrhea associated congenital acquired abnormalities cases poi remains classified idiopathic however age menopause inheritable trait poi strong genetic component confirmed existence several candidate genes experimental natural models variable expressivity poi defect may indicate disease may frequently considered multifactorial oligogenic defect common genetic contributors poi chromosome linked defects review principal linked autosomal genes involved syndromic non syndromic forms poi expectation list soon upgraded thus allowing possibility predict risk early age menopause families poi
fluid motion internal combustion engine induced induction process later modified compression process various methods improve efficiency engine super charging turbo charging varying stroke length varying injection pressure fuel air ratio additional strokes per cycle many require additional design stroke length injection pressure etc lead increase environmental effect objective study compare performance emissions circular nozzle guide vanes air swirl generating devices compression ignition engine investigation performed experiment four stroke single cylinder diesel engine test bed two different types guide vane profiles installed downstream air intake manifold increasing mixture quality air fuel combustion chamber initialization ignition engine load tests carried different loads without air swirl devices emissions engine also tested setup installation estimate environmental effects
background radiotherapy based premise accurate dose delivery target volumes within patient minimizing dose surrounding tissues recent developments treatment breast cancer focused gating delivery treatment beams minimize effect patient motion treatment increasing separation target volume organs risk oar lung heart left anterior descending coronary artery basic principle involves rapidly switching treatment beam depending patient breathing cycle therefore important know characteristics gated treatments latency methods work electrical pin diode circuit epdc designed quality assurance purposes examine beam latency timing properties evaluation epdc performed truebeam varian palo alto linear accelerator internal gating system epdc coupled moving stage simulate binary pattern fast beam triggering within predefined limits called gating window pulses radiation measured pin diode results compared measurements current produced across linac target processing beam pulses calculation latency timings performed atmegap microcontroller results beam latencies measured using pin diode compared using target current signal beam latencies measured using pin diode compared using target current conclusions pin diodes used accurate determination beam beam latency characteristics could potentially lead improvements gated radiotherapy treatments example optimizing gating windows estimating dosimetric errors associated treatment beam latencies agbm published elsevier masson sas rights reserved
lean management managerial approach focused enhancing customer value elimination non value adding steps work processes lean management also enjoying resurgence largely less philosophy particularly well suited austere conditions great recession recovery despite resurgence practitioners however academic research lean management particular research leadership lean initiatives remains limited study identify constellation lean values behaviors effective lean managers based extant research views expert practitioners field study lean managers first two empirical studies produce initial list values behaviors derived lean leadership literature three delphi rounds expert lean practitioners study corroborate refine list sample effective lean middle managers interviews survey fine grained video analyses situ behaviors meetings subordinates values identified include honesty candor participation teamwork continuous improvement indicative self transcendence openness change regarding behaviors find effective lean middle managers sample compared middle managers engage significantly positive relations oriented active listening agreeing behaviors significantly less task monitoring counterproductive work behaviors providing negative feedback defending one position conclude put forward five new propositions intended guide future research successful practice lean leadership elsevier ltd rights reserved
acute injuries sport still problem limited knowledge incidence severity different sports national level exists sweden sports federations mandatory injury insurance athletes insurance company injury data systematically kept national database aim study identify high risk sports respect incidence acute severe injuries sports reported database number incidences injuries well injuries leading permanent medical impairment pmi calculated year approximately injuries licensed athletes eligible analysis eighty five percent injuries reported football ice hockey floorball handball highest injury incidence well pmi motorcycle handball skating ice hockey females higher risk pmi compared males automobile sport handball floorball football high risk sports numerous injuries high incidence pmi injuries motorcycle handball ice hockey football floorball automobile sports thus sports ought target preventive actions national level
raise awareness understanding building information modeling bim laser scanning tools applications construction industry questionnaire administered participants different background workplaces results indicate participants positive perceptions employing tools workplace study also reports case study using bim laser scanning tools teknopark building north cyprus purpose cadeyes camera used capture building spatial visual data analyzed using revit generate model outcomes revealed efficient effective use tools construction sector findings study therefore recommend designers end users use applications order meet basic requirements design construction well deal challenges errors risks costs construction projects
article novel optimization algorithm called grey wolf optimization gwo theory quasi oppositional based learning obl proposed first time solve load frequency control lfc problem equal two area thermal power system equipped classical pid controller considered study power system network modeled governor dead band time delay nonlinearities get better insight lfc system load perturbation area considered appraise dynamic behavior concerned power system integral time absolute error least average error based fitness functions defined fine tuning pid controller gains employing proposed method extensive comparative analysis performed establish superiority proposed algorithm recently published algorithms finally sensitivity analysis performed show robustness designed controller system uncertainties
parents real beneficiaries school services involvement school based activities changed role breadth teachers schools handle parental involvement extra role behaviors teachers beyond job behaviors organizational citizenship behaviors ocb teachers crucial schools despite prescribed roles duties schools predict infer formally stated role job description entire range extra role behavior exhibited teachers school study teacher role breadth examined broad spectrum organizational citizenship behavior ocb resulted conceptual model determinants teacher ocb qualitative evaluation grounded theory interviews conducted stakeholders school india viz principals fellow teachers students parents striking finding teachers displaying prosocial behavior teacher ocb found three determinants ocb individual ocb organization ocb prosocial involvement parents school redesigning affecting actions teacher implications directions future research also discussed
recent years significant attention given renewable energy integration within context global climate change meantime energy water nexus literature recognized electricity water infrastructure enables production distribution consumption two precious commodities intertwined two issues may seem unrelated resolution potentially synergistic renewable energy technologies present low emissions also low water intensities well therefore renewable energy integration potential address sustainability concerns yet renewable energy integration studies yet methodologically consider integrated energy water infrastructure many works rely coupled unit commitment economic dispatch simulation recently simultaneous optimization method contributed economic dispatch networks include water power production facilities paper builds upon foundation development corresponding unit commitment problem demonstrates optimization several case studies inspired singapore middle east concludes renewable energy simultaneously reduces emissions water withdrawals furthermore shows water storage help alleviate binding production constraints flatten production profiles reduce production cost levels elsevier ltd rights reserved
nuclear factor nfic recently identified important player osteogenesis bone homeostasis vivo however molecular mechanisms involved yet defined current study nfic expression altered primary marrow stromal cells established progenitor lines adipogenic osteogenic treatment overexpression nfic stromal cells mesenchymal cells cht primary marrow stromal cells inhibited adipogenic differentiation whereas promoted osteogenic differentiation conversely silencing endogenous nfic cell lines enhanced adipogenic differentiation whereas blocked osteogenic differentiation mechanism investigations revealed nfic overexpression promoted nuclear translocation beta catenin increased nuclear protein levels catenin transcription factor like tcfl promoter studies chromatin immunoprecipitation chip assay revealed nfic directly binds promoter low density lipoprotein receptor related protein lrp thereafter transactivates promoter finally inactivation canonical wnt signaling attenuated inhibition adipogenic differentiation stimulation osteogenic differentiation nfic study suggests nfic balances adipogenic osteogenic differentiation progenitor cells controlling canonical wnt signaling highlights potential nfic target new therapies control metabolic disorders like osteoporosis obesity zhou wang yang zhu yuan liu wang nuclear factor reciprocally regulates adipocyte osteoblast differentiation via control canonical wnt signaling
osteoarthritis degenerative joint disease characterized cartilage degradation inflammation fisetin polyphenol extracted fruits vegetables reported anti inflammatory effects study aimed investigate effect fisetin vitro vivo vitro chondrocytes pretreated fisetin alone fisetin combined sirtinol inhibitor sirt beta stimulation production pge tnf alpha evaluated griess reaction elisas mrna cox inos mmp mmp adamts sox aggrecan collagen protein expression cox inos mmp mmp adamts sirt measured qrt pcr western blot respectively immunofluorescence used assess expression collagen sirt sirt activity quantified sirt fluorometric assay kit vivo effect fisetin evaluated gavage mice models induced destabilization medial meniscus dmm found fisetin inhibited beta induced expression pge tnf cox inos mmp mmp adamts besides fisetin remarkably decreased beta induced degradation sox aggrecan collagen furthermore fisetin significantly inhibited beta induced sirt decrease andinactivation however inhibitory effect fisetin obvious abolished sirtinol suggesting fisetin exerts anti inflammatory effects activating sirt vivo fisetin treated mice exhibited less cartilage destruction lower oarsi scores moreover fisetin reduced subchondral bone plate thickness alleviated synovitis taken together findings indicate fisetin may potential agent treatment elsevier rights reserved
background accumulating evidence suggests thiazolidinediones tzds may exert protective effects atrial fibrillation present meta analysis investigated association tzd use incidence diabetic patients methods electronic databases searched december initially identified records randomized clinical trials rcts observational studies diabetic patients included final analysis results pooled analysis included studies demonstrated patients treated tzds approximately lower risk developing compared controls odds ratio confidence interval association consistently observed new onset recurrent pioglitazone use rosiglitazone use association tzd use incidence significant pooled analysis three rcts significantly pooled analysis four observational studies conclusions meta analysis suggests tzds may confer protection setting diabetes mellitus class drugs used upstream therapy patients prevent development large scale rcts needed determine whether tzds use could prevent setting
aims objectivesto develop examine relocation stress intervention programme tailored family caregivers patients scheduled transfer surgical intensive care unit general ward backgroundfamily relocation stress syndrome reported similar exhibited patients investigators emphasised nurses make special efforts relieve family relocation stress maximise positive contributions well patients family caregivers designa nonequivalent control group nonsynchronised pretest post test design adopted methodsthe study subjects family caregivers patients neurosurgical general surgical conditions surgical intensive care unit university hospital located incheon south korea relocation stress family burden evaluated three times intervention immediately transfer four five days transfer resultsthis relocation stress intervention programme developed family caregivers based disease characteristics relocation related needs experimental group relocation stress levels significantly continuously decreased intervention whereas control group slight nonsignificant trend observed family burden levels control group increased significantly transfer whereas burden levels experimental group increased marginally nonsignificantly significant group differences relocation stress family burden levels observed intervention conclusionsrelocation stress levels family caregivers significantly decreased intervention experimental group indicates devised family relocation stress intervention programme effectively alleviated family relocation stress relevance clinical practicethe devised intervention programme tailored disease characteristics relocation related needs may enhance practicality efficacy relocation stress management make meaningful contribution relief family relocation stress promote patient recovery enhance well patients family caregivers
aims study evaluated efficacy repeated oral treatment two active pharmaceutical ingredients lcr lenio lcr restituo derivated probiotic bacterial strain lactobacillus rhamnosus lcr two animal models mimicking different features irritable bowel syndrome ibs ibs characterized visceral pain associated alteration bowel transit ibs patients present visceral hypersensitivity peripheral central origins methods results injection trinitrobenzenesulfonic acid tnbs proximal colon well acute partial restraint stress prs produces colonic hypersensitivity measured conscious rats decrease pain threshold response distal colonic distension visceral hypersensitivity produced injection tnbs days colonic distension acute prs testing day treatments performed day eight consecutive days conclusions study indicates day probiotic treatment lcr lenio lcr restituo produces antihypersensitivity activity tnbs prs visceral pain models probiotic strain attenuates peripherally centrally induced visceral hypersensitivity rats may active treatment ibs symptoms immunomodulatory effect probiotics highlighted tnbs model secretion suggesting mechanism action involving regulation local immune activation significance impact study two formulas lcr probiotic strain show encouraging results treatment ibs patients studies needed better understand role mechanisms probiotics pathogenesis ibs
successful execution intentions also failure recall common phenomena everyday life planning retention realization intentions often framed scientific concept prospective memory current study aimed examine influence acute stress key dimensions complex real life prospective memory end applied prospective memory task involved planning retention performance intentions fictional holiday week forty healthy males participated study half subjects stressed socially evaluated cold pressor test secpt planning intentions half participants underwent control procedure time salivary cortisol used measure effectiveness secpt stress induction stressed participants differ controls planning accuracy however compared stressed participants controls prospective memory retrieval found statistically significant differences across performance phase participants treated secpt procedure planning phase showed improved prospective memory retrieval time performance controls declined particularly significant difference stress control group last two days holiday week interestingly control participants showed significantly better performance early later learned items could indicator primacy effect differential effect stress performance also found time event dependent prospective memory results demonstrate first time acute stress induced planning phase may improve prospective memory time course performance phase time event dependent prospective memory data thus indicate prospective memory enhanced acute stress elsevier inc rights reserved
college students volleyball injury status reasons colleges lanzhou city volleyball option class aged similar years students sports injury investigation college students volleyball injury total incidence damage rate boys girls nearly times extracurricular injury class damage times sports injuries mainly fingers ankle joint knee joint three position accounting type injury soft tissue injuries sprain skin abrasion common accounting causes injury technical movement errors insufficient preparation accident field equipment students volleyball sports injury injury soft tissue skin abrasions sprains lesser extent common incidence high beignored school optimize teaching venues equipment configuration strengthen students sports injury prevention health care knowledge reduce incidence sports injuries
context reuse improve productivity maintainability software development research proposed wide range methods techniques successfully adopted practice objective propose preliminary answer integrating two depth empirical studies software reuse two large software producing companies method compare interpret study results focus reuse practices effects context results companies perform pragmatic reuse code produced within company leveraging available artefacts reusable entities retrieved central repository present otherwise direct communication trusted colleagues crucial access reuse processes remain implicit reflect development style homogeneous infrastructure supported context participants strongly agreed higher development pace less maintenance effort reuse benefits heterogeneous context fragmented infrastructure benefits materialize neither case reports statistically significant evidence negative side effects reuse inhibitors cases lack reuse led duplicate implementations conclusion technological advances improved way reuse concepts applied practice homogeneity development process tool support seem necessary preconditions developing adopting adequate reuse strategies heterogeneous contexts remains challenging elsevier inc rights reserved
general characteristics serially coupled multiple ring resonator smrr filters analyzed case ring resonators smrr identical perimeters coupling coefficients distribution provides passband characteristics steeper roll flatter top greater stopband rejection single ring resonator addition also designed simulated nonsymmetric vernier type smrr filters improving wide free spectral range fsr different ring radii expand fsr smrr vernier filters determined least common multiple fsr individual ring resonators improvement suppression interstitial resonances also investigated novel derivation optical transfer functions domain smrr filters expressed employing graphical approach ring resonators unequal perimeters represented signal flow graph diagrams
paper present converter multiple sources energy harvest internal combustion engine vehicle energy sources include solar panel regeneration energy braking thermal electrical generator since three energy sources different power rating power distribution control method proposed paper proposed power distribution control provides effectively specific power distribution control requiring less feedback signals thereby reducing cost converter etc specifications converter include input voltage ranging extends output power around output voltage details controller design simulation experimental results presented confirm effectiveness proposed multi source converter power distribution control method results show output voltage well regulated power distributions among different energy sources achieved prototype designed experimental results included confirmation
waste water animal production industry contains large amounts nitrogen phosphorus organic matter easily cause water pollution continuous cropping artemisia selengens causes accumulation serious soil borne pathogen fusarium oxysporum resulting serious disease cutting seedlings containment organic matter flowability waste water experiment assay biocontrol capacity waste water fortified biocontrol agent bacillus subtilis oxysporum performed results showed population soil significantly affected fusarium wilt disease incidence selengens higher population soil correlated lower disease incidence selengens effects factors irrigation quantity treated waste water tww irrigation quantity tap water percentage spores soil bulk density additive ratio adsorbent soil population bacillus spp determined irrigation quantity tww irrigation quantity tap water additive ratio poly gamma glutamic acid selected significant factors optimized using central composite design optimal factors tww irrigation quantity tap water irrigation quantity poly gamma glutamic acid additive ratio validation predictive gained population soil bacillus cfu close predicted value cfu compared control soil irrigated waste water soil irrigated waste water treatments disease incidence tww soil irrigated treated waste water treatment significantly decreased biocontrol efficacy tww treatment tww significantly decreased population oxysporum rhizosphere soil stem selengens findings support new value added application method waste water animal production industry elsevier rights reserved
background rates reported postoperative urinary retention following midurethral sling procedures highly variable determining patients higher likelihood failing voiding trial help preoperative counseling prior midurethral sling objective objective study identify preoperative predictors failed voiding trial following isolated midurethral sling study design retrospective multicenter case control study performed including isolated midurethral sling procedures performed jan june academic centers collected demographics medical surgical histories voiding symptoms urodynamic evaluation intraoperative data medical record excluded patients eligible attempted voiding trial surgery bladder perforation requiring catheterization cases failed postoperative voiding trial discharged indwelling catheter taught intermittent self catheterization controls passed voiding trial also recorded adverse events urinary tract infection voiding dysfunction weeks surgery bivariate analyses completed using mann whitney pearson chi tests appropriate multivariable stepwise logistic regression used determine predictors failing voiding trial results total patients isolated sling retropubic transobturator single incision failed initial voiding trial follow visits passed second voiding trial remainder passed third attempt bivariate analyses prior prolapse incontinence surgery similar cases controls age race body mass index operative time significantly cases controls charlson comorbidity index score greater overactive bladder symptoms urgency frequency urgency incontinence similar groups detrusor overactivity urodynamic evaluation nocturia reported cases mean bladder capacity similar groups maximum flow rate uroflowmetry pressure flow studies cases significantly likely voiding type detrusor contraction odds ratio confidence interval difference voiding trial failures retropubic transobturator routes within weeks surgery frequency urinary tract infection cases greater controls odds ratio confidence interval passing repeat voiding trial cases likely present acute urinary retention odds ratio confidence interval multivariable analyses increasing charlson comorbidity index increased risk voiding trial failure apart identify demographic information among patients undergo urodynamic evaluation reliably forecasted voiding trial failure conclusion majority women pass voiding trial first attempt isolated midurethral sling current medical comorbidities predictive voiding trial failure whereas demographic examination findings patients failing initial voiding trial increased risk postoperative urinary tract infection developing acute retention passing subsequent voiding trial
background electroencephalography eeg still widely used imaging tool combines high temporal resolution relatively low cost agcl metal electrodes gold standard non invasively monitoring electrical brain activity although reliable electrodes multiple drawbacks suffer noise offset potential drift usability issues example difficult skin preparation cross coupling adjacent electrodes new method order tackle issues prototype electric potential sensor eps device based auto zero operational amplifier developed evaluated eps novel active ultrahigh impedance capacitively coupled sensor absence noise makes eps ideal use signal frequencies similar less comprehensive study undertaken compare neural signals recorded eps standard commercial eeg system results quantitatively highly similar signals observed eps eeg sensors free running evoked brain activity cross correlations higher eps standard benchmark eeg system comparison existing method studies comprised measurements free running eeg event related potentials erps commercial eeg system eps conclusions eps provides promising alternative many added benefits compared standard eeg sensors including reduced setup time elimination sensor cross coupling future scalability eps allow implementation whole head ultra dense eps array elsevier rights reserved
endosulfan organochlorine pesticide widely used southwest china paper adsorption desorption characteristics endosulfan two typical agricultural soils latosol lateritic red soil area studied results showed langmuir isothermal equation could well describe adsorption thermodynamic characteristics endosulfan latosol lateritic red soil maximum adsorption capacities alpha endosulfan beta endosulfan respectively endosulfan adsorption two soils exothermic physicochemical process dominated physical process adsorption kinetic characteristics endosulfan two soils could well described second order kinetic equation initial rate constants min alpha endosulfan min beta endosulfan respectively adsorbed endosulfan two soils difficult desorbed liquid phase showed weak desorption hysteresis results implied endosulfan could firmly adsorbed two soils adsorption desorption abilities may related contents soil clay organic matter
semaphorin semaa immune modulator could participate pathogenesis autoimmune diseases current study aimed investigate semaa expression peripheral blood mononuclear cells pbmcs serum level relapsing remitting multiple sclerosis rrms patients fifteen newly determined untreated rrms patients chosen assessed relapsing remitting phases compare fifteen healthy individuals consistent previous findings autoimmune diseases results revealed serum level semaa expression pbmcs rrms patients significantly lower normal subjects also evaluated regulation predictive value roc analysis according data suggest semaa could involved pathogenesis might potential diagnostic biomarker disease elsevier rights reserved
present research finds anthropomorphism attributing human characteristics nonhuman objects increases consumers preference products superior appearance effect occurs consumers apply belief beautiful good pervasive stereotype person perception judgment anthropomorphized products seven experiments test propositions results show product anthropomorphism nonanthropomorphism leads consumers spend time money searching information appearance attributes experiments indicate greater preference products superior appearance experiments purchase products superior appearance experiments experiments also show effect anthropomorphism consumer preference mediated consumers conviction beautiful good person perception effect alleviated consumers beliefs association attractive physical appearance person positive personal traits person challenged results robust across wide range product categories consumers theoretical contributions marketing implications discussed
parents expectations known central component children development multiple pathways however limited information exists regarding expectations parents children developmental disabilities purpose current study examine future expectations parents children cerebral palsy well differences expectations mothers fathers forty nine mothers fathers children years participated study parents completed parental future expectations questionnaire children disabilities perception child ability questionnaire well pediatric evaluation disability inventory pedi gross motor function measure gmfm completed physical therapists parental differences future expectations analyzed multiple stepwise regressions established parental expectations predictors parents expectations correlated child characteristics parents children lower levels functioning reported lower expectations differences found mothers fathers future expectations however differences found expectations predictors predictors mothers expectations perceptions child abilities well child performance fathers predictors child level functional impairment perceptions child abilities results indicate parental expectations relate child functional ability differ parents relation child level impairment fathers child actual performance mothers differences acknowledged clinicians provide specific support children chronic physical disabilities families
cellulose chitosan intrinsic sorption properties iii however efficiency metal recovery easily improved relatively simple chemical modification grating aspartic acid via intermediary chlorination step polysaccharides allows increasing sorption capacities due specific reactivity carboxylate groups grafting process confirmed elemental analysis ftir spectrometry physical properties derivatives characterized xrd crystallinity tga thermogravimetric analysis sorption properties carried investigating effect studying uptake kinetics evaluating thermodynamics sorption isotherms sorption properties modified sorbents systematically compared performance raw materials sorption capacity doubled grafting aspartic acid onto biopolymer backbone sorption isotherms described freundlich langmuir equation maximum sorption capacities reach uptake kinetics described pseudo first order reaction rate selected experimental conditions equilibrium reached within contact sorption spontaneous endothermic metal desorption successfully performed nitric acid sorbents recycled least sorption desorption cycles without significant loss sorption desorption performances elsevier rights reserved
condition monitoring electric motor critical stable reliable operation consequence fault variation output performance changes input electrical signature one common methods fault detection analyzing input current signature often requires expensive sensors symptom faulty machine runs hot due increase losses generated temperature changes could useful indicator underlying fault paper method condition monitoring using temperature sensors embedded electric motor presented components electromagnetic losses generated determined indirectly temperature measurement real time continuous drive cycle simulating normal faulty operations achieved inversion thermal model machine coupled application recursive parameter estimation method using temperature measurement condition monitoring advantageous since temperature sensors low cost already embedded machine thermal protection however application method faulty motor evaluation effectiveness fault detection reported future work
pelvic floor disorders pfd including urinary incontinence anal incontinence pelvic organ prolapse common negative effect quality life women treatment associated morbidity may totally satisfactory prevention pfds possible primary goal purpose paper summarise current literature give evidence based review prevention pfds working subcommittee international urogynecological association iuga research development committee formed initial document addressing prevention pfds drafted based review english language literature evaluation entire iuga committee revisions made final document represents iuga committee opinion prevention pfds committee opinion reviews literature prevention pfds summarises findings evidence based recommendations pelvic floor disorders long latency may periods remission thus making causality difficult confirm nevertheless prevention strategies targeting modifiable risk factors incorporated clinical practice absence symptomatology
long term nationally representative studies cause mortality among infected hepatitis virus hcv additional years data made publicly available third national health nutrition examination survey linked mortality file became longest nationally representative study united states objective update estimated hcv associated cause mortality general population determine differences sex age race ethnicity hcv status assessed nationally representative adults aged years mortality follow individuals completed made publicly available deaths median follow years adjusting covariate risk factors chronic hcv times higher cause mortality rate ratio mrr compared hcv negative cause mrr stratified sex age race ethnicity race ethnicity significant effect modifier mrr highest mrr chronic hcv compared hcv negative among mexican americans among non hispanic whites among non hispanic blacks racial disparity seen cause mortality mexican americans chronic hcv approximately seven times higher mortality rate hcv negative individuals suggests risk individuals targeted hcv screening treatment given availability new highly effective hcv therapies
deleuze use thermodynamics fifth chapter masterwork difference repetition ushers perhaps crucial notion understanding work intensity given process actualisation relies intensive necessarily means discussion relationship virtual actual must include thorough explanation role intensity exactly notion sits within virtual actual doublet must return fifth chapter difference repetition order assess way deleuze conceives complex indispensable cog ontological metaphysical philosophy paper turn deleuze engagement theories intensive found classical thermodynamic theory quite simply deleuze highlight way productive force differences intensity remains appreciated contrast extensive states create classical framework understand engagement example way extensive continually privileged intensive paper outline details engagement deleuze thermodynamics paves way philosophy intensity furthermore provide theory relationship intensity virtual actual notions appear difference repetition
guidelines treatment atopic dermatitis issued japanese dermatological association jda basically designed dermatologists first prepared revised guidelines japanese society allergology usa basically designed allergologists including internists otorhinolaryngologists ophthalmologists dermatologists first prepared revised article review definition pathophysiology etiology epidemiology diagnosis severity classification examination diagnosis severity assessment treatments japan according two guidelines jda jsa based definition diagnostic criteria jda patients meeting three basic criteria pruritus typical morphology distribution eczema chronic chronically relapsing course regarded treatment measures basically consist drug therapy skin care elimination exacerbating factors drugs potently reduce related inflammation skin topical corticosteroids tacrolimus important promptly accurately reduce inflammation related using topical anti inflammatory drugs proactive therapy refers treatment method inducing remission topical corticosteroid tacrolimus ointment intermittently applied skin addition skin care moisturizers order maintain remission
adaptive suspended particle device spd switchable glazing promising low energy building application spd glazing allows light passes presence applied voltage block light absence power supply work spd glazing performance years outdoor exposure evaluated found contrast ratio spd glazing exposures changed spd glazing surface temperature transparency level varies degrees indoor outdoor thermal exposure spd glazing surface temperature variation occurs due incident radiation level transmission level glazing voltage power requirement spd glazing vary elevated glazing surface temperature
fibronectin containing extra domain eda functional glycoprotein participating several cellular processes correlates chronic liver disease herein aim investigate expression secretion eda hepatocytes nonalcoholic fatty liver disease nafld underlying mechanisms circulating levels eda determined elisa clinical samples western blotting flow cytometry performed hepg cell lines analyze whether levels eda associated endoplasmic reticulum stress related cell death circulating levels eda nafld patients significantly higher control subjects positively related severity ultrasonographic steatosis score cultured hepatocytes palmitate regulated expression eda dose dependent manner conversely cells pretreated phenylbutyrate specific inhibitor stress regulation eda could abrogated moreover silencing chop shrna enhanced release eda hepatocytes following palmitate treatment involved stress related cell damage findings suggest regulated level eda associated liver damage nafld stress mediated cell damage contributes release eda hepatocytes
ruxolitinib novel therapeutic agent used treatment myelofibrosis literature reports opportunistic infections along tuberculosis ruxolitinib treatment herein aimed report post polycythemic myelofibrosis case developed mycobacterial infection ruxolitinib treatment years old man diagnosed polycythemia vera years ago diagnosed post polycythemic myelofibrosis given hydroxycarbamide interferon treatments however ruxolitinib treatment started july spleen enlargement constitutional symptoms ruxolitinib started dose dose gradually increased september constitutional symptoms decreased cachexia improved january however started fever attacks investigations revealed origin fever quantiferon test resulted positive may tuberculosis pcr test negative however ada level found increased cerebrospinal fluid general condition patient deteriorated rapidly lost june afterwards mycobacterium tuberculosis complex detected patient culture sample ruxolitinib serious effects immune system conclude patients given ruxolitinib closely followed especially first months treatment benefits prophylactic use antivirals antibiotics investigated future studies
combined cycle power plants ccpps operation diverse thermodynamic cycle configurations assortment thermodynamic cycle scrupulous locality dependent type fuel available different utilities obtained plant present paper seven practically applicable configurations ccpp taken consideration exergetic energetic analysis component seven configurations conducted help computer programming tool engineering equation solver ees different pressure ratios case effects pressure ratio turbine inlet temperature ambient relative humidity first second law studied thermodynamics analysis indicates exergy destruction various components combined cycle significantly affected overall pressure ratio turbine inlet temperature pressure loss air filter less affected ambient relative humidity
automated sensing control system hardware software developed real time spot application granular fertilizer mowed wild blueberry fields custom hardware system incorporated commercial pneumatic granular fertilizer spreader custom software sensing control system developed combining color occurrence matrix based texture analysis ratio algorithms acquire process images real time differentiate mowed wild blueberry plants bare spots weeds performance accuracy spot applicable fertilizer spreader evaluated laboratory simulation real time field tests simulation results reported accuracy developed system real time field tests reported system produced acceptable results ground speeds spot application fertilizer target areas plant areas within field results also indicated ground speed unacceptable could due blurred images high speed surface unevenness wild blueberry field spot application fertilizer using modified fertilizer spreader could save fertilizer wild blueberry producers
objective study estimation burden serious fungal diseases france essential data inform public health priorities importance resources research needed infections france precise data available invasive fungal diseases estimates several diseases chronic immunoallergic diseases contrast less known materials methods systematic literature search conducted using web science platform published epidemiology papers reporting fungal infection rates france identified data existed used specific populations risk fungal infection frequencies populations estimate national incidence prevalence depending condition results model predicts high prevalences severe asthma fungal sensitization episodes cases adults per year allergic bronchopulmonary aspergillosis chronic pulmonary aspergillosis besides estimated incidence invasive aspergillosis annually based classical high risk factors estimates invasive mucormycosis pneumocystosis cryptococcosis respectively regarding invasive candidiasis cases per year estimated much higher number recurrent vaginal candidiasis probable must confirmed finally survey opportunity report first picture frequency tinea capitis france conclusion using local literature data incidence prevalence fungal infections approximately people france estimated suffer serious fungal infections year elsevier masson sas rights reserved
background national institute neurological disease stroke canadian stroke network ninds csn minute neuropsychology protocol consists verbal tasks proposed brief screening method vascular cognitive impairment evaluated feasibility within two weeks stroke ability predict development post stroke dementia psd months stroke method prospectively enrolled subjects ischemic stroke within seven days symptom onset consecutively admitted university hospitals neuropsychological assessments using ninds csn minute minute neuropsychology protocols administered within two weeks months stroke onset respectively psd diagnosed reference american heart association american stroke association statement requiring deficits least two cognitive domains results patients feasible ninds csn minute protocol within two weeks stroke incidence psd subjects completed follow months stroke onset total score ninds csn minute protocol differed significantly without psd respectively cut value showed reasonable discriminative power sensitivity specificity auc ninds csn minute protocol score significant predictor psd adjusted odds ratio discussion ninds csn minute protocol feasible evaluate cognitive functions patients acute ischemic stroke might useful screening method early identification high risk groups psd
objectives calreticulin calr mutations present jak mpl wild type myeloproliferative neoplasms mpns histopathologic features calr mutated mpns unknown methods identified patients essential thrombocythemia primary myelofibrosis pmf post essential thrombocythemia myelofibrosis post available calr status calr assessed using capillary electrophoresis followed sanger sequencing confirmation calr status correlated histopathologic features results megakaryocytes calr mutated pmf often hyperchromatic compared calr cases calr mutated showed megakagocytic clustering compared calr cases megakalyocytes calr mutated post predominance convoluted nuclei compared calr cases calr mutations frequent post compared conclusions calr mutated mpns higher frequency megakaryocytic aberrancies compared calr cases patients calr mutated appear likely develop myelofibrosis compared patients calr
research adult populations widely investigated deep differences characterize individuals embrace either conservative liberal views world recently research started investigate differences early stages life one major goal explore parental political ideology may influence children characteristics known associated different ideological positions present work investigate relations parents ideology children cognitive processing strategies within framework political ideology motivated social cognition jost dual process model political ideology duckitt specifically epistemic implicit attitudes toward order chaos existential negativity threat bias relational needs conformity measure assessed pre school children years child least one parent completed social dominance orientation sdo right wing authoritarianism rwa measures interestingly results indicated mothers fathers responses unique associations children socio cognitive motivations different findings emerged relation two facets parental authoritarianism namely dominance sdo submission rwa specifically children existential needs appeared related mothers rwa scores whereas children epistemic needs appeared related fathers sdo finally parents rwa sdo scores appeared opposite effects children relational needs children conformity increased increasing levels mothers rwa decreased increasing levels fathers sdo overall however results relatively weak several links responses parents children significant suggesting caution drawing strong conclusions impact parents ideology limitations future developments discussed
despite extensive research conducted subject problem three dimensional information systems historical cities actually still unresolved addition commercially available software seems increasingly aiming quick development unspecific urban settings rather metrically perceptively faithful representation reality scenario siur software sistema informativo urbano tridimensionale based management structure links interactive photorealistic metrically reliable model city qualitative database historical archaeological material scope architectural part application uses unity game engine geometrical models management equipped online data sharing
last three decades two process model sleep regulation served major conceptual framework sleep research applied widely studies fatigue performance dissect individual differences sleep regulation model posits homeostatic process process interacts process controlled circadian pacemaker process time courses derived physiological behavioural variables model simulates successfully timing intensity sleep diverse experimental protocols electrophysiological recordings suprachiasmatic nuclei scn suggest interact continuously oscillators outside scn linked energy metabolism evident scn lesioned arrhythmic animals subjected restricted feeding methamphetamine administration well human subjects internal desynchronization intact animals peripheral oscillators may dissociate central pacemaker rhythm sleep fast wake feed phase segregate antagonistic anabolic catabolic metabolic processes peripheral tissues deficiency process proposed account depressive sleep disturbances antidepressant effect sleep deprivation model supported development novel non pharmacological treatment paradigms psychiatry based manipulating circadian phase sleep light exposure conclusion model remains conceptually useful promoting integration sleep circadian rhythm research sleep appears short term use dependent function also serves enforce rest fasting thereby supporting optimization metabolic processes appropriate phase cycle
liquids gas bubbles commonly seen medical science natural science daily life engineering nonlinear wave symbolic computation dimensional variable coefficient kudryashov sinelshchikov model bubbly liquid hereby performed auto backlund transformation solitonic solutions obtained respect density fluctuation bubble liquid mixture auto backlund transformation solitonic solutions depend bubble liquid viscosity transverse perturbation bubble liquid nonlinearity bubble liquid dispersion coefficient functions note shock waves given solutions observed gas bubble liquid mixture experiments effects bubbly liquid respect bubble liquid viscosity transverse perturbation bubble liquidnonlinearity bubble liquid dispersion coefficient functions might detected future gas bubble liquid mixture experiments
investigate reliability new house automatic algorithm calculating magnetic resonance parkinsonism index mrpi large multicentre study population patients affected progressive supranuclear palsy psp parkinson disease healthy controls compare diagnostic accuracy automatic manual mrpi values study included psp patients patients controls mri performed using scanners automatic manual mrpi values evaluated accuracy methods distinguishing psp controls calculated statistical differences found automated manual mrpi values groups automatic mrpi values differentiated psp accuracy manual mrpi accuracy manual mrpi accuracy scanners respectively study showed new house automated method mrpi calculation highly accurate distinguishing psp automatic approach allows widespread use mrpi clinical practice longitudinal research studies aeuro cent new automatic method calculating mrpi presented aeuro cent automatic mrpi values good agreement manual values aeuro cent automatic mrpi distinguish patients psp patients aeuro cent automatic method overcomes mrpi application limitations routine practice aeuro cent automatic method may allow widespread use mrpi
tumour microenvironment determines fate treatments reconstitution tumour conditions mandatory alternative vitro methods devoted cancer development selection therapeutic strategies work describes model melanoma growth environment introducing means mimic tumour angiogenesis turns tumour progression model shows melanoma tumour spheroids allow reconstitution solid tumours stromal cells angiogenesis evidenced differential recruitment endothelial cells early progenitors eepcs mature ecs hypoxia key parameter selected stabilized melanoma cancer stem like cells cscs phenotype based aldehyde dehydrogenase expression best criterion tumour model demonstrated distinct reactivity ecs toward tumour cells terms cellular cross talk humoral response intra spheroid cell cell membrane dye exchanges mediated intercellular interactions uncovered melanoma eepc cooperation resulting changes tumour milieu evidenced chemokinic composition hypoxia related variations microrna expression assessed cellular component spheroids method brings new tools decipher molecular mechanism tumour mediated cell recruitment vitro assessment therapeutic approaches author published elsevier ireland ltd
ethanol drugs abuse able activate ventral tegmental area dopamine vta neurons leading positively motivational alcohol seeking behavior use ultimately ethanol addiction last decades involvement brain derived acetaldehyde acd ethanol actions mesolimbic pathway widely demonstrated consistent published results provided mechanistic support use acd inactivating agents block motivational reinforcing properties ethanol hence last years several pre clinical studies performed order analyze effects sequestering acd agents prevention ethanol relapse like drinking behavior well chronic alcohol consumption sense one explored interventions administration penicillamine pre clinical studies critically summarize article considered critical step potential development novel pharmacotherapeutic strategy alcohol addiction treatment could improve outcomes current ones thus one hand several experimental findings provide rationale using novel therapeutic intervention alone combination prevent relapse alcohol seeking consumption hand effectiveness reducing voluntary ethanol consumption long term experienced animals still remains unclear finally drug offers additional advantage already approved use humans hence could easily implemented new therapeutic intervention relapse prevention alcoholism
although previous studies show overwhelming evidence loneliness negatively correlated prosocial behavior theories research implied certain situations loneliness plays positive role individual social functioning two studies reported article examined loneliness associations prosocial behavior chinese adults using subjective reporting experimental design study examined chinese adults males using social emotional loneliness scale adults prosocial tendencies measure evaluate loneliness prosocial tendencies results showed loneliness negatively associated prosocial tendencies except public prosocial tendency study examined chinese adults males using experimental design found lonely women public situations expressed greater willingness help results also suggest loneliness may play positive role social functioning individuals certain conditions function loneliness implications association loneliness prosocial behavior discussed
last quarter twentieth century new class materials geosynthetics emerged prospectively leading significant innovation design geotechnical geoenvironmental systems geotextiles proven among versatile techno economically viable ground modification materials playing significant role modern pavement design maintenance techniques growing environmental concern across globe technologists researchers inclined towards natural geotextile jute geotextile jgt one potential candidates jgt restricted mainly underlay road construction hence urgent need design develop precise innovative fabric overlay existing pavements emerging civil works stay technically economically competitive global market fabric prove techno economically viable also reduce carbon foot print generation large extent paper delineates development grey jute paving fabric gjpf followed bituminization suitable type grade bitumen develop bituminized jute paving fabric bjpf bjpf enhance life overlay thereby reducing cost maintenance well serving partial substitute bitumen mastic
study developed novel mobile industrial scale fluidized adsorption process preliminarily explored application emergency water treatment lab based liquid solid circulating fluidized bed lscfb prepared flow pattern studied validated computational fluid dynamics cfd models simulation results revealed particular uneven flow structure could weaken aniline removal performance occurred increasing superficial liquid velocity accordingly optimized distributor design constructed established cfd models notably effect open angles flow pattern often overlooked previous studies mainly discussed aniline removal efficiency lscfb pre post optimization compared experimental results demonstrate dynamic adsorption capacity aniline reached optimum conditions initial aniline concentration superficial liquid velocity sorbent dosage comparison fixed bed adsorption lscfb possessed significantly higher adsorption rate constants shorter hydraulic retention time indicates lscfb could meet emergency treatment requirements better way finally study developed mobile industrial scale fluidized adsorption process estimated process parameters aniline removal sudden water pollution accident zhuozhang river society powder technology japan published elsevier society powder technology japan rights reserved
objective determine frequency thyroid dysfunction patients type diabetes patients seen dow university hospital karachi methodology observational study carried national institute diabetes endocrinology dow university hospital ojha campus karachi pakistan january december type diabetes mellitus patients years duration evaluated thyroid status proven thyroid disorder treatment type patients gestational diabetes mellitus fibrocalculous pancreatitis pancreatitis steroid induced diabetes excluded laboratory evaluation thyroid functions done estimation serum tsh levels results patients male female ratio mean age years range years patients suffered years patients years years duration mean tsh level mean free mol mean free mol hyperthyroidism observed patients sub clinical hypothyroidism patients rest cases within normal range conclusion patients screened thyroid function unrecognized thyroid dysfunction lead metabolic disturbances also increased risk fatal atherosclerotic events rawal med
study investigate potential moricandia arvensis methanol leaf extract meohl calpain activity melanin biosynthesis dna mutagenicity cytotoxic effect measurement reactive oxygen species ros induced lucigenin colorectal cells also determined addition chemical analysis extract also studied chemical profile illustrates content para hydroxybenzoic acid hba glycosylated kampferol glycosylated kampferol rhamnose gkr amino acids aas results showed meohl extract enhanced significant cytotoxic max antioxidant max activities furthermore tested extract stimulated calpain activity significantly increased production intra cells extracellular melanin content using ames assay extract exhibits significant inhibition mutagenicity induced methy methane sulfonate mms well aminoanthracene salmonella thyphimurium assay system
alternative fuels important role play spark ignition compression ignition engines prime reasons need trim dependency gasoline fuel economic aspects many investigations primarily focused using alternative fuels see diminishing effect fuel consumption aim review study analyze range opportunities future prospects introducing blends gasoline ethanol gasoline alcohols derivative subsequent alternative fuels varying percentage ratios existing spark ignition engines diagnosing various aspects air fuel ratio operating cylinder pressure ignition timing compression ratio related performance parameters ethanol blends lower proportions showed increment range engine torque brake power brake specific fuel consumption bsfc increased higher volume ethanol content range brake thermal efficiency bte slightly higher side range ethanol gasoline blend used
imagining oneself performing simple action trigger false memories self performance phenomenon called imagination inflation however people often imagine others behavior actions according visual similarity account imagining another person actions induce kind memory error false memory self performance tested account three experiments performance followed imagination imagination phase participants asked either imagine imagine another person performing actions previously performed two weeks later surprise source memory test administered participants decide whether depicted action performed performed results revealed imagining another person trigger false memories self performance however visual similarity performance imagination predicted amount false memories imagination self imagination findings consistent research suggesting self imagination rely different mechanisms imagination primarily involves visual imagery self imagination primarily involves motor imagery accordingly false action memories imagination may result visual similarity whereas false action memories self imagination may result motor simulation elsevier rights reserved
persons intellectual disability group risk exposed overly demanding problem solving situations may produce learned helplessness research based informational model learned helplessness consequences exposure unsolvable task ability recognize symptoms cognitive exhaustion tested students mild intellectual disability exposure unsolvable task persons experimental group obtained lower results control group escape avoidance learning task similar result found divergent thinking fluency task also participants experimental group difficulties recognizing symptoms cognitive exhaustion state week time difference escape avoidance learning performance still observed results indicate exposure unsolvable tasks may negatively influence cognitive performance persons intellectual disability although persons may identify cognitive state related lowered performance
detection tunnel lining cracks key procedure inspection tunnels traditional image processing approaches commonly based characteristic grayscale value crack local minimum however issues low contrast uneven illumination severe noise pollution generally exist tunnel lining image hence traditional image processing method effectively detect cracks tunnel lining surface paper presents three step method identify extract cracks infrared images tunnel lining first image preprocessed frequency domain second conditional texture anisotropy pixel computed image subblock optimum threshold obtained iteration method thus cracks image subblock determined according threshold finally cracks subregion connected experimental results show proposed method effectively detect tunnel lining surface cracks american society civil engineers
verification validation agent based models abms challenging underlying structure model agents change time furthermore theoretical context model often different established models phenomenon effort overcome issues trace validation becoming common mechanism within agent based modeling community trace validation characteristics agents model tracked time analyzed subject matter experts smes gain insight unexpected potentially invalid output present tool calculator applies predicates employed field software engineering result structured trace validation approach quantifiable measures facilitates sme exploration insight causes unexpected output within abms
hot humid regions due limitation peak power vital reduce electrical power consumption multi chiller systems since consumption noticeably increases chillers improperly managed aim optimal chiller loading ocl one important issues systems ultimate aim ocl problem determine partial load ratio plr chiller respect cooling load demand owing nonlinearity ocl problem powerful search method employed efficiently solve problem paper general algebraic modeling system gams proposed solve ocl problem gams efficient easy implement high level computer programming language modeling solving optimization problems linear nonlinear mixed integer order evaluate efficiency proposed methodology two case studies solved results compared results obtained conventional heuristic search methods results represent gams produces promising results comparison methods elsevier ltd rights reserved
rapid advancement technology today smartphones become powerful attract huge amount users new features provided mobile device operating systems android however due security vulnerability hackers cybercriminals constantly attack android mobile devices thus research effective efficient mobile threat analysis becomes emerging important topic cybersecurity research area using various security analysis evaluation strategies static analysis dynamic analysis paper propose hybrid approach aggregates static dynamic analysis detecting security threat attack mobile app approach implement unification data states software execution critical test path approach two phases first perform static analysis identify possible attack critical path based android api existing attack patterns next perform dynamic analysis follows path execute program limited focused scope detect attack possibility checking conformance detected path existing attack patterns second phase runtime dynamic analysis dynamic inspection report type attack scenarios respect type confidential data leakage web browser cookie without accessing real critical protected data sources mobile devices
paper presents new topology emulating floating lossless negative immittance functions proposed circuit uses three current feedback operational amplifiers cfoas three passive elements functionality proposed circuit verified using advanced design system ads software cfoa simulation results obtained floating negative lossless inductance emulator excellent agreement theoretical calculations
purpose reviewthe purpose study review recent studies examined association endogenous exogenous testosterone mortality older men recent findingsover past several years steep rise testosterone prescriptions increased use testosterone occurred context several studies reported association low serum testosterone increased cardiovascular events mortality contrast recent studies reported association testosterone treatment adverse events testosterone treatment trial mobility impaired elderly men prevalent cardiovascular disease stopped due increased cardiovascular events treated men meta analysis reported increased cardiovascular events treated men two recent large observational studies testosterone treatment associated increased risk serious adverse cardiovascular events summarylow testosterone associated mortality multiple cohort studies however unclear causal association due low testosterone biomarker poor health given recent reports adverse outcomes associated testosterone treatment conservative use testosterone warranted men cardiovascular disease may greater risk adverse outcomes
shault linear voltage regulators still used situations kinds regulators advised paper explores mechanism liable induce long duration pulses similar devices eventually demonstrated using pulsed laser facility data issued tests helps understand electrical network parameters well non idealities devices affect characteristics transients finally phenomenon investigated similar structures identical purpose elsevier rights reserved
background characterization mature protein termini large scale proteomics challenging especially true proteins undergoing cleavage transit peptides targeted specific organelles mitochondria chloroplast protein neo termini located amino acids downstream initiator methionine easily predictable although bioinformatics tools available usually require extensive manual validation identify exact terminal position situation becomes even complex post translational modifications take place neo terminus although terminal acetylation occurs mostly cytosol also observed organelles chloroplast date bioinformatics tool available define mature protein starting positions associated terminus acetylation status yield proteoform context developed encounter tool score characterized peptides using discriminating parameters identify bona fide mature protein termini determine terminus acetylation yield reliable ones results based large scale proteomics analyses using silpronaq methodology tandem mass spectrometry favoured characterization thousands peptides data processing using encounter tool provided efficient rapid way extract reliable mature protein termini selected peptides subjected terminus acetylation yield determination thaliana cell lysate distinct proteotypic termini characterized located predicted protein terminus position located downstream starting position large number termini associated various well defined maturation processes occurring organelle targeted proteins mitochondria chloroplast peroxisome secreted proteins membrane targeted proteins also possible highlight protein alternative starts splicing variants erroneous protein sequence predictions conclusions encounter tool provides unique way extract accurately relevant mature proteins terminal peptides large scale experimental datasets data processing allows identification exact terminus position associated acetylation yield
recombined fingerprints suggested convenient approach improve efficiency anonymous fingerprinting legal distribution copyrighted multimedia contents systems recombination idea inspired principles mating recombination heredity dna sequences living beings applied binary sequences like genetic algorithms however existing recombination based fingerprinting systems provide convenient solution collusion resistance since require double layer fingerprinting codes making practical implementation systems challenging task fact collusion resistance regarded relevant requirement fingerprinting scheme lack acceptable solution problem would possibly deter content merchants deploying practical implementation recombination approach paper drawback overcome introducing two non trivial improvements paving way future real life application recombination based systems first nuida collusion resistant codes used segment wise fashion first time second novel version traitor tracing algorithm proposed encrypted domain also first time making possible provide buyers security framing addition proposed method avoids use public key cryptography multimedia content expensive cryptographic protocols leading excellent performance terms computational communication burdens fact bootstrapping merchant longer required participate file transfer reducing investment equipment required content distribution bare minimum paper also analyzes security privacy properties proposed system formally informally whereas collusion resistance performance method shown means experiments simulations elsevier ltd rights reserved
objective perform systematic review meta analysis studies investigating neurocognition euthymic youths bipolar disorder compared healthy controls hcs method systematic literature search conducted pubmed medline psycinfo embase databases inception march original peer reviewed articles investigated neurocognition euthymic youths compared hcs effect sizes individual tests extracted addition results grouped according cognitive domain review complied prisma statement guidelines results total studies met inclusion criteria overall euthymic youths significantly impaired verbal learning verbal memory working memory visual learning visual memory moderate large ess hedge significant impairments observed attention vigilance reasoning problem solving processing speed heterogeneity moderate large estimates differences definition euthymia across studies explained heterogeneity estimate verbal learning memory also found evidence potential sources heterogeneity several estimates including occurring attention deficit hyperactivity disorder adhd anxiety disorders use medications addition use different neuropsychological tests appeared contribute heterogeneity estimates attention vigilance domain conclusion euthymic youths exhibit significant cognitive dysfunction encompassing verbal learning memory working memory visual learning memory domains data indicate subset individuals neurodevelopmental factors may contribute cognitive dysfunction
adoption quality assurance methods based software process improvement models regarded important source variability software productivity companies perceive implementation prohibitive costs whereas authors identify use way comply software development patterns standards produce economic value lead corporate performance improvement paper investigate relationship quality maturity levels labor productivity using data set containing brazilian software firms study relationship labor productivity measured annual gross revenue per worker ratio quality levels appraised according two distinct software process improvement models mps cmmi perform independent statistical tests using appraisals carried according models consequently obtaining data set many observations possible order seek strong support research first show mps cmmi appraised quality maturity levels correlated find statistical evidence related higher labor productivity productivity growth contrary present evidence suggesting average labor productivity higher software companies without appraised quality levels moreover analyses suggest companies appraised quality maturity levels less productive depending factors business nature main origin capital maintained quality level
primary sjogren syndrome pss chronic autoimmune disease might progress mucosal associated lymphoid tissue lymphoma pss malt diagnosis pss requires invasive tissue biopsy delay diagnosis pss frequently reported study four proteins including cofilin alpha enolase annexin rho gdp dissociation inhibitor rgi found expressed pss pss malt gel electrophoresis mass spectrometry finding verified microarray analysis western blotting results developed enzyme linked immunosorbent assays autoantibodies including anti cofilin anti alpha enolase anti rgi good quantitative ability expression levels salivary anti cofilin anti alpha enolase anti rgi found highest pss malt patients lowest healthy controls combination three antiantibodies yielded area curve auc value sensitivity specificity distinguishing patients pss healthy controls auc value sensitivity specificity distinguishing patients pss malt healthy controls auc value sensitivity specificity distinguishing pss malt patients pss patients collectively successfully identified panel potential autoantigens progressively regulated development pss progression malt lymphoma autoantibody biomarkers may used help diagnose pss predict progression malt lymphoma
background aim study evaluate treatment efficacy patient acceptability new bipolar probe used office hysteroscopic treatment benign intrauterine pathologies methods observational clinical study women treated benign intrauterine pathologies using office hysteroscopic procedure without analgesia anaesthesia versapoint bipolar electrical generator used treat endometrial polyps ranging well submucosal partially intramural myomas treatment efficacy patient compliance evaluated results follow uterine cavity normal patients without recurrence persistence pathology one focal adenocarcinoma discovered histology endometrial polyp menopausal patient patient acceptance satisfactory patients underwent procedure without discomfort conclusions combination new generation small diameter hysteroscope new bipolar electrode enables gynaecologist treat intrauterine pathologies office setting without anaesthesia experimentation special set electrical generator reduced patient discomfort operative part hysteroscopic procedure
advance massively parallel computing nineteen nineties beyond encouraged finer grid intervals numerical weather prediction models improved resolution weather systems enhanced accuracy forecasts setting trend development unified scale atmospheric models paper first outlines historical background wide range numerical methods advanced process next trend illustrated technical review versatile nonoscillatory forward time finite volume nftfv approach proven effective simulations atmospheric flows small scale dynamics global circulations climate outlined approach exploits synergy two specific ingredients mpdata methods simulation fluid flows based sign preserving properties upstream differencing flexible finite volume median dual unstructured mesh discretisation spatial differential operators comprising pdes atmospheric dynamics paper consolidates concepts leading family generalised nonhydrostatic nftfv flow solvers include soundproof pdes incompressible boussinesq anelastic pseudo incompressible systems common large eddy simulation small meso scale dynamics well scale compressible euler equations framework naturally extends predictive skills large eddy simulation global atmosphere providing bottom alternative reverse approach pursued weather prediction models theoretical considerations substantiated calculations attesting versatility efficacy nftfv approach prospective developments also discussed elsevier inc rights reserved
intranasal administration neuropeptide oxytocin appears positive social consequences effects often highly context person specific present research examined whether core personality trait extraversion may one important person specific factor plays role associations across two double blind randomized placebo controlled studies total study study observed significant interactions administration extraversion predicting prosocial outcomes individuals low extraversion administration relative placebo led greater perceived social connection prosocial tendencies study positive behavioral responses help greater trust interaction partner study contrast administration beneficial individuals high extraversion overall findings contribute growing evidence administration complex person specific effects social behavior indicating extraversion plays important role associations
given varied benefits using simulation packages cost efficiency time risk mitigation greater insights user friendliness systems extensively used many application domains defense airports manufacturing engineering healthcare currently due increasing numbers simulation software packages available market often challenging choose suitable package meets users demands researchers leveraged many assessment methods techniques facilitate evaluation selection process simulation packages paper provides survey corroborated researcher contributions simplify selection process simulation packages also discerns evaluation methods techniques simulation packages found literature authors published elsevier
outpatient follow ideally dedicated multidisciplinary team team ibd nurse key point access education advice support investigated effect introduction ibd nurse quality care delivered methods september ibd nurse position instituted tertiary referral center contacts outcomes prospectively recorded month period using logbook kept nurse results september august patient contacts recorded men median age years crohn disease immunosuppressive therapy contacts increased time september november contacts assigned scheduling follow start new therapy therapy follow providing disease information addition patients contacted ibd nurse flare management smaller number administrative support psychosocial support questions side effects study period emergency room unscheduled outpatient visits could avoided intervention ibd nurse faster access procedures departments could provided patients conclusion role ibd nurses first point contact counseling evident high volume nurse patient interactions avoidance emergency room unscheduled clinic visits associated contacts copyright wolters kluwer health inc rights reserved
paper presents digital active electrode dae system multi parameter biopotential signal acquisition portable wearable devices built around performs analog signal processing digitization help chip instrumentation amplifiers bit adc digital interface via standard bus digital active electrodes channels connected commercially available microcontroller thus significantly reducing system complexity cost addition dae utilizes innovative functionally coupled amplifier preserve input signal still achieving state art performance sqrt input referred noise electrode offset tolerance common mode feedforward scheme improves cmrr pair maximum
paper describes implementation load voltage observer control algorithms rapid capacitor charger controlled digital signal controller dsc fast dsp core hybrid peak current mode control algorithm digital control pwm signal high speed analog current sensing used control inverter charger dsc controller keeps current loop stable using adaptive slope compensation addition providing fast adaptive digital control current loop dsc perform additional functions estimation voltage level load capacitor avoids cost bandwidth limitations insulation challenges conventional sensor evaluate performance load voltage observer measured output voltage laboratory grade probe establish reference test results digital algorithm
performance many machine learning algorithms heavily relies distance metrics usually distance metric learned training set valuable information group structure samples within short distance form group may contain several classes sample may partial memberships multiple groups group structure exists training test sets additionally outliers negative effects distance metric increasing number noisy samples learning phase may increase negative effects outliers use weights one way alleviate problem similar samples given weight paper introduces learning technique weighted distance metric semi supervised method learns labeled information training set identifies groups among samples test set form metric space experiments nearest neighbors algorithm used classifier proposed weighted distance metric improves classification accuracy furthermore parallel computing optimized cpu gpu code developed speed computing time two parallel implementations matlab cuda compared research parallel code uses cpu gpu achieves times speedup compared traditional cpu code experiments
paper presents new neutronics thermal hydraulics code atac based advanced jacobian free newton krylov jfnk method low dimensional equivalent strategy conventional operator splitting strategies used maintain accuracy small time steps linearization nonlinear problem leads slow computation speed linearization error jfnk method solves troubles coupled neutronics thermal hydraulics problems mentioned furthermore core wide three dimension one dimension equivalent method developed provide variable group parameters finally performance coupled neutronics thermal hydraulics code atac studied simulating four oecd nea crp pwr rod ejection benchmark problems simulation results compared reference ones proves developed code good accuracy practicability nuclear reactor transient calculation elsevier ltd rights reserved
paper presents new switching cycle state space model modular multilevel converter mmc basis unused switching states converter explored corresponding new control method proposed paper begins comprehensive summary analysis prior art modeling approaches mmc various models used mmc discussed limits controlling converter shown followed complete derivation proposed state space switching model whose mathematical derivation leverages simply state variable transformations kirchhoff voltage law without losing circuital characteristics converter result possible switching states many previously used operating modes converter effectively unveiled switching cycle control approach proposed taking advantage developed state space switching model new control scheme greatly reduce cell capacitance arm inductance value well enable mmc operate terminal frequency without affecting voltage ripple capacitors simulation results shown validate converter operations using new control scheme
present study focuses measuring effects industrial wastewater disposed thermal electricity power plant product geotechnical properties sandy soil applying washing process remediate contaminated soil samples measure efficiency washing technique disturbed sandy soil samples obtained kufa city located southwest iraq industrial wastewater obtained musayib thermal electricity power plant intact sandy soil contaminated laboratory four percentages industrial wastewater calculated according weight dry soil industrial wastewater mixed distilled water constitute solution used contamination process soil soaking soil solution days study results showed increasing percentages contaminant slight increase liquid limit particle size significant increase optimum water content nevertheless slight decrease observed specific gravity maximum dry unit weight void ratio considerable decrease noticed angle internal friction coefficient permeability soil proposed remediation technique soil washing efficient economical time saving used remediate sandy soils remediation results showed increase cohesion angle internal friction maximum dry unit weight also slight increase observed specific gravity void ratio permeability coefficient remediated soil samples compared contaminated samples removal efficiencies contaminant soil soil samples contaminated industrial wastewater respectively
purpose review chronic headache sufferers estimated around population patients high disease burden prophylactic treatments low efficacy tolerability patients need alternative therapeutic strategies options recent findings last decade number neuromodulation procedures introduced treatment chronic intractable headache patients pharmacological treatments fail well tolerated neurostimulation peripheral central nervous system carried various non invasive invasive stimulation devices available noninvasive neurostimulation options include vagus nerve stimulation supraorbital stimulation single pulse transcranial magnetic stimulation invasive procedures include occipital nerve stimulation sphenopalatine ganglion stimulation hypothalamic deep brain stimulation many cases results supporting use derive open label series small controlled trial studies lack adequate placebo hampers adequate randomized controlled trials summary paper give overview main neurostimulation procedures terms results putative mechanism cation
background objective distinguishing cancer subtypes critical selecting appropriate treatment strategy bioinformatics approaches gradually taken place clinical observations pathological experiments however approaches typically used gene expression profiling previous studies primarily focused gene level specific diseases thus pathway level factors considered therefore computational method integrates gene expression pathway necessary methods study presented approach determine potential fragments activated pathways around protein networks different stages disease used scored equation integrates genomic proteomic information determined intensity pathway link change support vector machine svm used train test subtype predicted models results performance proposed method evaluated calculating prediction accuracy average prediction accuracy three subtypes tumors neuroepithelial tissues results demonstrate proposed method applies fewer features gene expression methods used obtain similar results conclusions study suggests method implement cancer subtype classifier based svm pathway level perspective elsevier rights reserved
arm servers becoming increasingly common making server technologies virtualization arm growing importance present first study arm virtualization performance server hardware including multi core measurements two popular arm hypervisors kvm xen show arm hardware support virtualization enable much faster transitions vms hypervisor key hypervisor operation however current hypervisor designs including type hypervisors xen type hypervisors kvm able leverage performance benefit real application workloads discuss reasons show factors related hypervisor software design implementation larger role overall performance based measurements discuss changes arm hardware virtualization support potentially bridge gap bring faster hypervisor transition mechanism modern type hypervisors running real applications changes incorporated latest arm architecture
present work analyzed hydromagnetic effect three dimensional couette flow viscous incompressible electrically conducting newtonian fluid porous medium bounded two horizontal parallel porous flat plates transverse sinusoidal injection fluid stationary plate corresponding removal periodic suction plate uniform motion flow becomes three dimensional due injection suction velocity approximate solutions obtained flow field pressure skin friction temperature field rate heat transfer found cross velocity reduced considerably rise magnetic body parameter permeability parameter injection suction forward flow reverse effect observed backward flow increase found escalate main flow velocity whereas increase magnetic body parameter shown exert opposite effect similarly shear stress due main flow considerably increased increase results show methods perturbation electrical network schemes provides excellent approximations solution nonlinear system high accuracy acquired knowledge study used designers control magnetohydrodynamic mhd flow suitable certain application possible applications include materials processing mhd propulsion thermo fluid dynamics boundary layer aerodynamics chemical engineering etc elsevier ltd rights reserved
paper presents new method manufacturing hollow shafts tubes used billet first design specially designed forging machine rotary compression described machine numerically tested regard strength effect elastic strains roll system quality produced parts determined machine strength calculated finite element method using nastran program technological capabilities machine determined next results modeling rotary compression process hollow stepped shafts finite element method given process manufacturing hollow shafts modeled using simufact forming simulation program fem results verified experimentally designed forging machine rotary compression experimental results confirm axisymmetric hollow shafts produced rotary compression method also confirmed numerical methods suitable investigating machine design metal forming processes
backgroundthe aim present study determine prevalence metabolic syndrome individual components among iranian adult population investigate changes methodsdata two rounds surveillance risk factors non communicable diseases national surveys conducted pooled metabolic syndrome defined according international diabetes federation criteria resultsin prevalence metabolic syndrome among adults aged years confidence interval decreased despite overall decline prevalence central obesity raised triglycerides reduced high density lipoprotein cholesterol hdl remained constant trend towards decline proportion individuals increased blood pressure proportion adults increased fasting plasma glucose fpg increased prevalence central obesity raised triglycerides reduced hdl increased blood pressure increased fpg respectively conclusionsover period prevalence metabolic syndrome decreased slightly iran although prevalence increased fpg increased significantly one third iranian adult population diagnosed metabolic syndrome
large cities rainwater tanks used save mains water peri urban rural areas rainwater tanks used sole water supply many households regions often means water supply paper investigates performance rainwater harvesting system rwhs peri urban regions greater sydney australia considering daily rainfall data entire period record ten different locations found tank meet demand toilet laundry use depending location greater sydney regions however driest year tank meet toilet laundry demand depending location based results life cycle cost analysis found tank highest benefit cost ratio ranging among eight possible tank sizes examined study interestingly tank combined use toilet laundry irrigation current water price sydney needs increased achieve benefit cost ratio exceeding one set regression equations developed used estimate reliability using average annual rainfall data arbitrary location peri urban regions greater sydney method presented paper also applied australian states countries estimate water savings reliability rwhs using daily rainfall data
paper presents results investigation effect decrease drainage capacity hydraulic deterioration tunnel geosynthetic drainage systems structural performance tunnel linings use geosynthetics tunnel construction first introduced together summary geotextile filter design principles practices series stress pore pressure coupled finite element analyses carried number tunnel cases order investigate effect hydraulic deterioration tunnel drainage layer structural performance tunnel linings shown decrease drainage capacity drainage layer significantly increases axial thrust bending moment tunnel lining pronounced increases bending moment also revealed hydraulic deterioration induced lining forces tend increase hydraulic head slightly decrease cover depth also shown progressive development hydraulic deterioration induced lining forces best fit exponential function used predict lining force increase given tunnel condition practical implications findings discussed
facial first impressions literature focused trait dimensions less research social categories like gender may influence first impressions faces yet social psychological studies shown importance categories like gender evaluation behaviour investigated whether face gender affects positive negative evaluation faces terms first impressions manipulated facial gender stereotypicality facial trustworthiness dominance examined valence resulting spontaneous descriptions male female faces male female participants counter stereotypical masculine dominant looking female faces perceived negatively facially stereotypical male female faces examined facial dominance trustworthiness affected rated valence across male female ambient face images replicated finding dominance negatively evaluated female faces effect found short stimulus presentations findings integrate facial first impressions literature evaluative differences based social categories
evidence post mortem human brains animal studies cell culture models implicated neuroinflammation aetiology chronic neuropathologies including alzheimer parkinson diseases although neuroinflammatory response considered detrimental contributing pathologies underlying mechanisms still well understood type interferons ifns well characterised periphery known initiate modulate immune response recently implicated ageing also demonstrated increased type ifn expression post mortem human alzheimer parkinson disease brains hypothesise type ifns key drivers damaging self perpetuating pro inflammatory response contributes chronic neuropathologies support recently confirmed models alzheimer parkinson disease mice lacking type ifn receptor ifnar display attenuated neuroinflammatory response subsequent neuroprotection investigate type ifn mediated neuroinflammation specific cns cell types involved study treated primary cultured wild type ifnar neurons mixed glia mitochondrial complex inhibitor rotenone wild type neurons glia treated rotenone respectively exhibited pro inflammatory response including increased type ifn expression attenuated cells lacking ifnar reduced type ifn signalling ifnar neurons also conferred protection caspase mediated rotenone induced cell death reduced pro inflammatory response ifnar glia subsequently diminished neurotoxic effects wild type neurons support confirmed therapeutically targeting type ifn glial response rotenone specific ifnar blocking monoclonal antibody neuroprotective data confirmed neurons glia contribute pro inflammatory response induced rotenone attenuation response beneficial reducing neuronal cell death
previous research shown neonatal rats adapt stepping behavior response sensory feedback real time current study examined real time persistent effects rom range motion restriction stepping rats day testing rat pups suspended sling min baseline treated serotonergic receptor agonist quipazine saline vehicle control half pups plexiglas plate placed beneath limb length induce period rom restriction stepping entire test session included min baseline min rom restriction min post rom restriction periods following treatment quipazine increase fore hindlimb total movement alternated steps pups pups also showed synchronized steps pups rom restriction period suppression forelimb movement synchronized steps find evidence persistent effects rom restriction amount stepping however real time persistent changes intralimb coordination occurred developmental differences also seen time course stepping pups subjects showing show less stepping younger pups results suggest sensory feedback modulates locomotor activity period development neural mechanisms locomotion undergoing rapid development published elsevier
nowadays mobility grants undergraduate students leading increase number foreign students enrolled many universities normally european students receive erasmus grant provided european commission contributes exchange students european countries many times receiving host university offer chance attend lectures english goes labs usually foreign students individual tutorial sessions assessments english present paper show methodology conduct lab sessions teaching multilingual group engineering students group consideration consists spanish students non spanish speaking students lab lectures taught spanish methodology proposed allows teaching aforementioned foreign students methodology based performing previous homework prepare students fulfill successfully laboratory activities video lessons recorded order show step step perform lab english subtitles added videos enough well explained students demonstrate basic level english easily understand activities proposed several videos recorded included work illustrate teaching process videos show typical practice lessons taught various subjects mechanical faculty university jaen thermodynamics metrology manufacturing engineering one reasons methodology proposed unify bilingual teaching methodology several subjects another one related students whose mother tongue english currently students must acquire skills allow work multilingual group propose activities integrate spanish foreign students finally opinion survey developed order determine improvements learning process
fungal infections major cause animal plant morbidity mortality worldwide effective biological therapeutics could complement current antifungal drugs understanding vivo mechanisms hampered technical barriers intravital imaging host pathogen interactions characterize fungal infection zebrafish model understand mechanism action biological antifungal therapeutics intravital imaging transparent animals find non specific human igg enhances phagocytosis zebrafish phagocytes vivo polyclonal anti candida antibodies enhance containment fungi vivo promote survival analysis suggests early phagocytic containment strong prognostic indicator overall survival although polyclonal anti candida antibodies protect disease necessarily case individual monoclonal anti candida antibodies thus zebrafish appears provide useful model host testing biological therapeutic promotes phagocytosis vivo enhances protection candidemia elsevier ltd rights reserved
ankylosing spondylitis systemic autoimmune disease mainly affecting lumbar spine sacroiliac joints exhibits peripheral inflammatory arthropathy loci identified associated rheumatoid arthritis autoimmune diseases may share common genetic factors therefore examined newly identified genetic polymorphisms associated taiwanese population study enrolled patients healthy subjects taiwanese biobank controls although none single nucleotide polymorphisms snps associated susceptibility disease index bath global bas clinical phenotype observed significantly correlated genotype csf significance remains gender age disease duration adjustment group categorization human leukocyte antigen hla genotype investigated possible functions bioinformatics approaches results revealed polymorphism able influence expression acyl coa synthetase long chain family member acsl conclusion study indicated csf strongly associated disease index bath global bas clinical phenotype
nanotechnology provides new method modified cement introduces research application nano cement situation existing problems paper nano cement better mechanical properties durability current ordinary cement environmentally friendly improve microstructure cement order improve physical mechanical properties durability reduce energy consumption current focus study microstructure mechanical properties nano concrete well prepare inexpensive nanomaterials future nano cement wider application field
complex analytic invariants hypersurface isolated singularities considered context symbolic computation motivations paper computer calculations sequences introduced teissier study whitney equisingularity deformations complex hypersurfaces new algorithm utilizes parametric local cohomology systems proposed compute sequences lists sequences typical cases also given
combined cycle power plant ccpp one efficient systems energy conversion different topping bottoming cycles one acceptable schemes combination brayton rankine cycle analyzed various design parameters present analysis thermodynamic modelling ccpp single steam extraction bottoming rankine cycle carried study effect inlet air temperature tat cycle ratio turbine inlet temperature tit air compressor gas turbine efficiency first second law efficiency parametric analysis computer programming tool engineering equation solver ees used thermodynamic properties many fluids gases inbuilt function software results concluded combustion chamber source highest exergy destruction followed heat recovery steam generator gas turbine air compressor steam turbine increase tit optimum also found increased gas turbine efficiency gas turbine exhaust temperature increased optimum cycle ratio
spinal cord compression due extramedullary hematopoiesis emh rare complication thalassemia generally presents paraparesis sensory impairment complete paraplegia extremely rare emh due thalassemia although known occur polycythemia vera sickle cell anemia cases presenting paraparesis treated either surgery radiotherapy equal frequency efficacy almost reported cases paraplegia treated surgery without radiation therapy paraplegia secondary emh rare consensus treatment hereby report case thalassemia paraplegia treated successfully surgery treatment options cord compression include primarily blood transfusion surgery radiation therapy extreme rarity condition direct comparisons various treatment modalities possible bias toward surgery due immediate decompressing effect emh thalassemia also treated transfusion therapy rationale correction anemia would downregulate erythropoietin lead reversal emh however improvement blood transfusion alone usually incomplete slow patient improve adequate blood transfusion hence underwent surgical decompression showed rapid complete neurologic recovery therefore conclude surgical decompression emh tissue considered early patients presenting paraplegia symptom shows improvement adequate blood transfusion
essay examines crisis maupassant self isolating bachelors face separation initially sought peers becomes stifling isolation noose loneliness slowly tightens around house becomes scene terrific visions loners unaccustomed company hear footsteps soon confronted ghostly horla recurring figure many fantastic tales essay argues guy maupassant short stories paradoxical liminal figure bachelor double horla crystallize crisis masculine identity end nineteenth century horla appears fantastic trope expression anxiety associated shifts gender roles inability maupassant bachelors connect others following journey broken men end inhabiting liveable psychic social place essay shows maupassant bachelor protagonists become hors
objectives hypothesized parents physically abused child high risk physically abuse child form negative less positive impressions children nonabusive low risk abuse parents however date overall evidence several individual studies testing hypothesis inconclusive method current meta analysis compared impressions abusive high risk abuse parents nonabusive low risk abuse parents form children results overall estimated difference parents impressions children standard deviation hypothesized direction confidence interval difference found among studies using variety procedures variety dependent variables analysis distribution values published studies corroborated finding conclusions collectively current meta analysis confirms differences abusive high risk abuse parents nonabusive low risk abuse parents impressions children however despite clear evidence existence effect current results suggest magnitude effect modest future research determine whether parents impressions meaningfully related parents child directed behaviors research would informative whether parents impressions children targeted interventions aimed reducing physically abusive parenting behaviors
background dementia high burden patients informal caregivers society given changes care systems persons dementia live longer home however living home dementia good quality life easy achieve dementia often accompanied neuropsychiatric symptoms like apathy agitation depression anxiety negative impact quality life whereas cognitive deterioration hardly influenced possible reduce neuropsychiatric symptoms autobiographical memories remain intact relatively long time dementia reminiscence interventions promote feelings pleasure trust online life story book olsb allows digitally share memories stories pictures video audio fragments main objective study effects olsb neuropsychiatric symptoms study four secondary objectives study effectiveness intervention burden quality life primary informal caregiver provide preliminary health economic evaluation study time nursing home admittance longer term effect provide process evaluation methods design randomized controlled trial individual randomization one two conditions conducted intervention online life story book control condition care usual participants persons early dementia primary caregivers intervention olsb trained volunteer guides participants process putting together timeline lives meetings within period weeks assess effects intervention primary outcome neuropsychiatric symptoms neuropsychiatric inventory npi assessed three time points intervention baseline months months post baseline discussion proven effective online life story book valuable addition existing provision care persons dementia informal caregivers
advanced chemical remediation strategies advanced oxidation processes aops turned feasible solution treatment bio refractory effluents case olive mill wastewater omw review paper focus relevant state art advanced physico chemical processes including ozonation wet oxidation fenton reagent photocatalysis coagulation flocculation well electrochemical solar driven hybrid processes treatment omw presented particular extent recalcitrant organic pollutants abatement efficiency grade mineralization achieved various treatments available today addressed special attention given different configurations treatment line sequences important effect parameters novel materials implementation real industrial scale latter includes latest advances applications omw treatment biopolymers coagulation flocculation ferromagnetic nanocatalyst ease recovery multiple long term use low cost catalysts doped nanocatalysts enhanced sunlight activation zeolite based catalysts mixed doped electrodes among others solutions reported management secondary sludge produced treatment processes also discussed moreover glance specific energy consumption associated costs comparison different processes proposed also given elsevier rights reserved
latino children systematically underdiagnosed autism spectrum disorder asd therefore important recent changes diagnostic process exacerbate pattern identification previous research found autism diagnostic interview revised adi algorithm based diagnostic statistical manual mental disorder fourth edition text revision dsm limitations latino children spanish speaking parents evaluated whether adi algorithm based new dsm classification asd would sensitive identifying latino children spanish speaking parents clinical diagnosis asd findings suggest dsm algorithm shows better sensitivity dsm algorithm latino children
autism spectrum disorder asd common complex neurological condition affecting approximately people worldwide monogenic neurodevelopmental disorders showed autistic behavior patterns suggested synaptic dysfunction key mechanism pathophysiology asd subsequently genes involved synaptic signaling investigated priority candidate gene studies synaptosomal associated protein snap gene plays crucial role central nervous system contributing exocytosis targeting fusion vesicles cell membrane studies shown correlation aberrant expression snap variety brain diseases single nucleotide polymorphisms snps gene associated several psychiatric diseases bipolar schizophrenia attention deficit hyperactivity disorder aim present study investigate whether polymorphisms regulatory untranslated region utr snap gene association asd unrelated iranian case control samples observed robust association snp asd patients allele haplotype based analyses results supported previous observations indicated possible role snap polymorphisms susceptibility genetic factors involved developing asd
white nose syndrome wns fungal disease responsible decimating many bat populations north america pseudogymnoascus destructans psychrophilic fungus responsible wns prospers winter habitat many hibernating bat species immune response elicits bats yet fully understood antibodies produced response infection may protective indeed may harmful understand bats respond infection hibernation studied effect inoculation survival gene expression captive hibernating myotis lucifugus varying pre hibernation antifungal antibody titres investigated gene expression transcription selected cytokine genes ila ilb ifng associated inflammatory immune responses wing tissue lymph nodes found difference survival bats low high anti titres although anti antibody production hibernation differed significantly infected uninfected bats transcription ila higher lymph nodes infected bats compared uninfected bats increased transcription cytokines lymph node suggests pro inflammatory immune response wns restricted infected tissues occurs hibernation resulting response may protective euthermic bats may disrupt torpor could detrimental hibernation
comparison processes ubiquitous person perception comparative thinking follow two routes people either search similarities dissimilarities comparing two routes efficient previous research indicates people could compare two geometrical figures faster focused similarities rather dissimilarities examine comparisons people measure consumption cognitive resources indicator efficiency results confirm efficiency advantage similarity focused comparisons social stimuli
studies focusing effect stress false memories using psychosocial physiological stressors yielded diverse results present study systematically tested effect exogenous hydrocortisone using false memory paradigm placebo controlled study healthy men healthy women mean age years received either hydrocortisone placebo min using false memory deese roediger mcdermott drm paradigm used emotionally charged neutral drm based word lists look false recognition rates comparison true recognition rates overall expected increase false memory hydrocortisone compared placebo differences cortisol placebo group revealed false true recognition performance general false recognition rates lower compared true recognition rates furthermore found valence effect neutral positive negative disgust word stimuli indicating higher rates true false recognition emotional compared neutral words found interaction effect sex recognition post hoc tests showed true recognition women showed significantly better memory performance men independent treatment study support hypothesis cortisol decreases ability distinguish old versus novel words young healthy individuals however sex emotional valence word stimuli appear important moderators
certain environmental conditions accumulation dust change weather conditions affect amount solar radiation received photovoltaic panel surfaces thus significant effect panel efficiency study conducted experimental investigation surabaya indonesia effect factors output power reduction surface module module exposed outside weather conditions connected measurement system developed using rule based model identify different environmental conditions rule based model clear sky solar irradiance model included solar position temperature model used estimate output power tests also conducted using arm cortex microcontroller stmf standalone digital controller equipped voltage current temperature humidity sensors measure real time output power system humidity monitored identify dusty cloudy rainy conditions validated test results demonstrate prediction error power output based model compared field measurements clean surface conditions effects dust accumulation weather conditions panel power output analyzed one four weeks exposure results revealed two weeks dust accumulation caused power output reduction average relative humidity results experiment rainy conditions revealed decrease output power average relative humidity decrease output power cloudy conditions average relative humidity observed study reveals local environmental conditions dust rain partial cloud significantly reduce power output elsevier ltd rights reserved
functioning glymphatic system network paravascular tunnels cortical interstitial solutes cleared brain recently linked sleep traumatic brain injury affect progression migraine led investigate connection migraine glymphatic system taking advantage novel vivo method developed using two photon microscopy visualize paravascular space pvs naive uninjected mice show single wave cortical spreading depression csd animal model migraine aura induces rapid nearly complete closure pvs around surface well penetrating cortical arteries veins lasting several minutes gradually recovering min temporal mismatch constriction dilation blood vessel lumen closure pvs suggests closure likely result changes vessel diameter also show csd impairs glymphatic flow indicated reduced rate intraparenchymally injected dye cleared cortex pvs first observation apvsclosure connection abnormal cortical event underlies neurological disorder specifically findings demonstrate link glymphatic system migraine suggest novel mechanism regulation glymphatic flow
united nations sustainable development goal targets access water sanitation people next years however developing countries nepal challenging achieve goal given poor infrastructure high population growth assess water crisis developed populated area nepal kathmandu valley estimated available water resources domestic water demand valley estimated supply deficit million liters per day mld completion first phase melamchi water supply project mwsp mwsp completed within specified timeframe sufficient treatment distribution infrastructure developed would water deficit indicates mwsp make significant contribution valley water security however emphasis must given utilizing water available mwsp developing sufficient water treatment distribution infrastructure alternate mitigation options planning land use potential recharge introducing micro macro level rainwater harvesting structures conjunctive use surface groundwater resources water demand side management would also helpful
background purpose data monitoring committees responsible safeguarding interests study participants assuring integrity credibility clinical trials independence data monitoring committees sponsors investigators essential achieving mission creative approaches needed address ongoing emerging challenges potentially threaten data monitoring committees independence effectiveness methods expert panel representatives academia industry government sponsors regulatory agencies discussed challenges proposed best practices operating principles effective functioning contemporary data monitoring committees results conclusions prospective data monitoring committee members need better training options could include didactic instruction well apprenticeships provide real world experience data monitoring committee members protected legal liability arising service avoiding breaches confidentiality interim data remains high priority data monitoring committees access unblinded efficacy safety data throughout trial enable informed judgments risks benefits overly rigid procedures compromise independence data monitoring committees flexibility necessary best fulfill responsibilities data monitoring committee charters articulate principles guide data monitoring committee process rather list rigid set requirements data monitoring committees develop recommendations consensus rather voting processes format meetings data monitoring committee maintain committee independence clearly establish leadership data monitoring committee chair independent statistical group statistical data analysis center sufficient depth knowledge study hand experience trials general ensure data monitoring committee access timely reliable readily interpretable insights emerging evidence clinical trial contracts engaging data monitoring committee members industry sponsored trials language customized unique responsibilities data monitoring committee members rather use language appropriate consultants product development regulatory scientists would benefit experiencing data monitoring committee service conflict regulatory responsibilities
article explores illicit labor imprisonment two women cynthia dinah santa monica prison lima peru lens gendered motherwork unequal distribution care places burden labor women cynthia dinah primarily responsible care adult children diagnosed aids women entered transnational cocaine commodity chain order provide children medication administered state neoliberal healthcare form cuts national health systems makes motherwork poor women difficult perform order afford care children health cynthia dinah entered labor market criminalized punitive war drug policies subsequently imprisoned illicit labor therefore extension motherwork removal care children resulted tragic health consequences article based ethnographic dissertation fieldwork largest women prison peru
wireless sensor networks installed hostile areas security issues wireless sensor networks important getting secure links nodes challenging problem wsns vulnerable security attacks wired networks order protect sensitive data wsn protected using secret keys encrypt exchanged messages communicating nodes key management essential many security services confidentiality authentication symmetric asymmetric key cryptography trusted server schemes used solve problem asymmetric key cryptography increases network security increases computational memory energy overhead symmetric key cryptography provides less security efficient key management scheme trusted server schemes use key management server usually trusted infrastructure suitable sensor networks paper proposed mobile agent based key distribution makd makd mobile agents used dissemination public keys update shared keys sensor node constructs different symmetric keys neighbors communication security achieved data encryption mutual authentication keys simulation results show makd scalable less memory overhead
concept monosomal karyotype adult acute myeloid leukemia aml patients introduced defined presence chromosomal aberration pattern characterized presence least two autosomal monosomies one monosomy plus one structural aberrations including loss chromosome present systematic review literature influence outcome patients affected myeloid malignancies aml myelodysplastic syndromes primary myelofibrosis review comprehensive literature search using term monosomal karyotype performed considering articles listed medline analysis literature confirms negative prognostic impact survival myeloid neoplasias detrimental effect aml patients outcome independent variables including adverse cytogenetic features supporting identification entity challenging subgroup patients distinct biologic clinical features
conventional taught learning practices often experience difficulties keeping students motivated engaged video games however successful sustaining high levels motivation engagement set tasks hours without apparent loss focus addition gamers solve complex problems within gaming environment without feeling fatigue frustration would typically comparable learning task based notion academic community keen exploring methods deliver deep learner engagement shown increased interest adopting gamification integration gaming elements mechanics frameworks non game situations scenarios means increase student engagement improve information retention effectiveness applied education debatable though attempts generally restricted one dimensional approaches transposing trivial reward system onto existing teaching materials assessments nevertheless gamified multi dimensional problem based learning approach yield improved results even applied complex traditionally dry task like teaching computer programming shown paper presented quasi experimental study used combination instructor feedback real time sequence scored quizzes live coding deliver fully interactive learning experience specifically kahoot classroom response system crs classroom version game show wants millionaire codecademy interactive platform formed basis learning model applied entry level python programming course students thus allowed experience multiple interlocking methods similar commonly found top quality game experience assess gamification impact learning empirical data gamified group compared control group taught traditional learning approach similar one used previous cohorts despite relatively small scale study results findings number key metrics including attendance downloading course material final grades encouraging proved gamified approach motivating enriching students instructors
main aim study objectify treatment assignment criteria used clinical centre addiction treatment spain sample patients inpatients outpatients sought treatment assessed clinical characteristics addiction severity psychopathological symptoms impulsiveness maladjustment two treatment groups inpatient outpatient patients assigned according clinical criteria therapists analysed identify variables relevant patient placement moreover therapeutic progression patients met meet assignment criteria received studied according results score family social support area european addiction severity index europasi cases score family social area europasi score partner subscale maladjustment scale correctly classified cases inpatients outpatients comparisons therapeutic results depending matching mismatching assignment criteria showed larger effect size mismatching patient assignment criteria outpatient treatment results obtained study provide objective criterion addicted patient placement moreover cost effective perspective question necessity inpatient treatment cases demonstrating outpatient treatment sufficient level care study addresses approach assigning patients treatment modality best fits implementing least expensive level care needed achieve treatment success elsevier inc rights reserved
matched pole zero mpz model widely used technique discrete time approximation continuous time controllers article new state space representation mpz model presented new formulation used direct discretization state space controllers easily automated digital computer important advantage proposed representation preserves dynamic structure original continuous time realization physical meaning states direction eigenvectors remain unchanged fact new method provides exactly dynamic state equations step invariant model together modifications static output state equation due lack eigenstructure preserving state space representations time domain studies effects discrete approximation analog controllers mostly performed using step invariant model although method seldom used actual discretization controllers new formulation paves way extending studies case widely used mpz method sharif university technology rights reserved
pull range phase locked loop pll key parameter evaluating performance pll circuit defined maximum detuning frequency range loop locks different methods proposed computing pull range phase locked loops absence time delay paper effect time delay pull range second order phase locked loop well dynamical behavior discussed time delay modeled using first order pade approximation using pade approximation nonlinear second order delay differential equation describes phase error dynamic pll transformed fourth order system state space representation new time delay pll model simulated different behavior observed different typical pll system without delay gain loop increases new behavior change circuit stability chaos recognized suggests gain loop arbitrary large compare pull range time delay pll without time delay results demonstrate degradation pull range time delay pll moreover result shows pull range gets narrower time delay increases
purpose physical activity related injuries children constitute costly public health matter influence motor performance injury risk unclear purpose study examine motor performance risk factor traumatic overuse lower extremity injuries normal population children methods study included participants old baseline participating childhood health activity motor performance school study denmark follow period months motor performance tests static balance single leg hop distance core stability tests vertical jump shuttle run cardiorespiratory fitness test lower extremity injuries registered clinicians using weekly questionnaires classified according international classification diseases revision system results poor balance increased risk traumatic injury foot region incidence rate ratio irr good performance single leg hop distance protected traumatic knee injuries irr good performance core stability tests vertical jump increased risk traumatic injuries foot region irr poor balance increased risk overuse injuries foot region irr good performance core stability tests shuttle run especially knee injuries irr conclusions poor balance sway performance consistent predictor traumatic injuries particular traumatic ankle injuries good motor performance core stability vertical jump shuttle run positively associated traumatic overuse injuries negatively single leg hop associated traumatic injuries indicating different influences injury risk previous injury confounder affecting effect size significance studies needed consolidate findings clarify influence different performance tests different types injuries examine influence behavior relation injury risk
widely accepted classic metaphyseal lesion cml traumatic lesion strongly associated abuse infants nevertheless various non traumatic origins cmls continue suggested medical legal settings studies date systematically describe association cmls traumatic injuries primary objective study examine association cmls traumatic injuries large data set children evaluated physical abuse retrospectively planned secondary analysis data prospective observational study children months age underwent evaluation child abuse physician secondary analysis identified children parts per thousand currency sign months age identified cml determined number type additional injuries identified descriptive analysis used report frequency additional traumatic injuries among subjects identified cml least one additional non cml fracture thirty three traumatic brain injury nearly half children cutaneous injuries oropharyngeal injuries found children abdominal thoracic injuries also found children children cml least one additional injury one four children three categories injury cmls identified young children strongly associated traumatic injuries identification cml young child prompt thorough evaluation physical abuse
paper introduce analysis design new web based interactive software tool called webubu developed serve undergraduate students needs related linux operating system issues aim software development twofold one hand familiarize students ubuntu environment hand promote self learning related linux distribution context everyday classrooms wbubu software used interactive demonstration features linux lectures support instructors evaluation students skills lab tasks long term studying linux based physical linux must used software essentially website simulates ubuntu operating system inside web browser undergraduate students easily explore graphical user interface gui command line ubuntu environment additionally students ascertain acquired knowledge automated examination process learn mistakes shown automatically software real time educator manage students performances stored database system assess individual cognitive progress resulting software contribution however webubu give students chance practice self assessment involved university educational process physical linux unavailable software intends complement existing teaching learning methods concerning operating systems wiley periodicals inc
severity sustained injury resulting assault related violence minimised reducing detection time however shown human operators perform poorly detecting events found video footage presented simultaneous feeds utilise computer vision techniques develop automated method abnormal crowd detection aid human operator detection violent behaviour observed behaviour city centre environments often occurs crowded areas resulting individual actions occluded crowd members propose real time descriptor models crowd dynamics encoding changes crowd texture using temporal summaries grey level occurrence matrix features introduce measure inter frame uniformity demonstrate appearance violent behaviour changes less uniform manner compared types crowd behaviour proposed method computationally cheap offers real time description evaluating method using privately held cctv dataset publicly available violent flows ucf web abnormality umn abnormal crowd datasets report receiver operating characteristic score respectively
nonverbal behavior plays crucial role human communication often leads misunderstandings people different cultures even speak language fluently translation systems available verbal communication translators nonverbal communication exist yet present conceptual design early prototype real time gesture translator using body tracking gesture recognition avatar mediated intercultural interactions contributes ambitious goal bridging cultures translating culture specific gestures enhance mutual understanding possible applications gesture translator discussed facilitating tool global business meetings means technology enhanced conflict resolution prevention
trinidad tobago oil exporting small island developing state sids contribution global emissions important socio economic challenges producer electricity transport fuel subsidies interesting juncture subsidy reform government faces embeddedness distributive justice norms contested fiscal prudence environmental stewardship norms value paper twofold first develops subsidy intractability framework explain reform global narratives highlights power agents nature contested economic justice environmental norms availability mechanisms reform second framework used explain reform narratives trajectories trinidad tobago using data public documents unique elite survey former present heads state politicians policy makers stakeholders even conditions falling oil prices national revenue pressures reduce emissions redistributive justice arguments heavily embedded public discourses aspects subsidy developmental distributive justice goals intractable results study implications carbon emission reduction strategies developing states fossil fuel reserves
institutions higher education seek instil students scientific competencies throughout guidance different included courses curriculums however assimilation diverse methodologies evidence lack development scientific competencies necessary professionals graduated therefore required labour market research examines research competencies students higher education sample determine appreciation towards scientific competencies consider developed educational processes results prove perception subjects respect development interpersonal intrapersonal skills decision making problem solving acquisition scientific competences basic ones use technology appropriation new knowledge self learning search information specialized competences drafting reports design articles presentations development degree works definition new projects application anova detects significant differences according gender subjects competencies referred search physical information women stand reading comprehension documents english men stand besides demonstrated competences contribute students critical thinking ies required include research mechanism strengthen education
order reduce stress fuel cell based hybrid source fed electric drive system controller design made active current sharing acs technique effectiveness proposed acs technique tested drive system fed fuel cell battery energy sources enables load current sharing source power management high efficiency reliability hybrid system achieved proper energy conversion management power meet load demand terms required voltage current overcome slow dynamics feature battery bank adequate power capacity incorporated voltage drops heavily fast load demand controller allows fuel cell operate normal load region draw excess power battery order demonstrate performance drive using acs control strategy different modes operation hybrid source static dynamic behavior control system verified simulation experimental results control scheme implemented digitally labview pci daq interface card efficacy controller performance demonstrated system changing condition supplemented experimental validation elsevier ltd rights reserved
financial incentives used increasingly encourage wide array health behaviors well established efficacy however little known translate incentive based strategies public health practice geared toward improving population level health dearth research exists individuals respond incentives public health communication strategies direct mail study reports results population based randomized controlled trial testing direct mail incentive based intervention promoting mammography uptake study population composed random sample minnesota women enrolled medicare fee service overdue breast cancer screening participants randomized three groups direct mail direct mail plus incentive control direct mail groups received two mailers message importance mammography however mail plus incentive mailers also offered incentive getting mammogram logistic regression analyses measured intervention effects results showed odds receiving mammography significantly higher direct mail plus incentive group compared direct mail control groups use incentives also proved cost effective additionally direct mail group likely receive mammography control group findings offer experimental evidence population based strategy direct mail coupled financial incentive encourage healthy behavior well incentive based programs translated health promotion practice aimed achieving population level impact
paracoccidioidomycosis systemic fungal infection caused paracoccidioides brasiliensis endemic certain areas central south america report case year old man complex history tuberculosis imaging findings cerebral lesion bilateral adrenal enlargement biopsy adrenal gland revealed paracoccidioides brasiliensis case highlights importance travel history diagnosis paracoccidioidomycosis non endemic areas emphasizes clinical histopathological similarities tuberculosis
introduction surgical simulators designed improve operative skills patient safety transcanal endoscopic ear surgery tees relatively new surgical approach slow learning curve due one handed dissection reusable customizable dimensional printed endoscopic ear surgery simulator may facilitate development surgical skills high fidelity low cost herein aim design fabricate test low cost reusable printed tees simulator methods tees simulator designed computer aided design cad software using anatomic measurements taken anthropometric studies cross sections external auditory canal samples traced vectors serially combined mesh construct modified tympanic cavity modular testing platform simulator tasks incorporated components fabricated using calcium sulfate hemihydrate powder multiple colored infiltrants via commercial inkjet printing service results components left sided ear printed scale six right handed trainees completed three trials mean trial time ranged using dominant hand dissection statistically significant differences first last completion time dominant hand average completion time junior senior residents suggest construct validity conclusions printed simulator feasible tees simulation otolaryngology training programs access printer may readily fabricate tees simulator resulting inexpensive yet highfidelity surgical simulation elsevier ireland ltd rights reserved
aruba trial concluded medical management alone superior medical management plus interventional therapy treatment unruptured brain arteriovenous malformations bavms sparked considerable controversy among involved healthcare providers evaluated impact aruba volume type treatment modality bavms referred large tertiary care center achieved conducting retrospective review prospectively maintained database bavms treated stanford health care stanford children health january july case volume bavms treated stanford relatively unchanged period time leading aruba furthermore significant change proportion unruptured avms treated although differences existed types interventions administered differences best explained variations grades avms treated study period rather underlying changes treatment strategy additional research warranted thoroughly characterize impact aruba treatment patterns bavms elsevier ltd rights reserved
nitric oxide associated insulin resistance type diabetes mellitus association suggested single nucleotide polymorphism gluasp variant endothelial nitric oxide synthase enos gene increased risk however role polymorphism favouring investigated hypogonadism low testosterone obesity believed play major role aimed evaluate whether enos gene single nucleotide polymorphism gluasp variant might give relevant contribution also onset hypogonadism associated men affected late onset hypogonadism retrospectively reviewed patients clinically biochemically evaluated detection enos gluasp polymorphism performed splitting sample according three genetic variants enos enos enos difference evident age body mass index bmi total testosterone conversely prevalence glycaemia glycated haemoglobin significantly higher enos enos enos logistic regression analysis showed adjustment age bmi total testosterone enos positively significantly associated study suggests gluasp single nucleotide polymorphism enos gene may independent risk factor hypogonadism associated type
introduction active safety systems led significant increase passenger car safety however statistics road accidents show improvements active systems would necessary paper presents dynamical model engine car brakes system used simulate vehicle deceleration calculate risk injuries model used quantify performance active safety systems specific collision scenarios several vehicle cruising speeds different values distance obstacle causes active system activation considered base system constituted actual hydraulic brakes embedded abs first compared ideal active system latter allows maximum vehicle deceleration owing ideal operation hydraulic brakes supported abs also mechatronic actuation anticipates human intervention eliminates delay due reaction time model used analyse feasible evolution ideal active safety system internal combustion engine friction power aids vehicle speed decrease action brakes
introduction discovery development therapeutic strategies treatments parkinson disease synucleinopathies limited lack understanding pathomechanisms connection different diseases cancers areas covered hallmarks diseases frequently multifunctional disordered proteins displaying moonlighting chameleon features challenging drug targets representative proteins disordered tubulin polymerization promoting protein tppp expressed specifically oligodendrocytes olgs normal brain non physiological level tightly related etiology multiple system atrophy tppp enrichment inclusions neurons olgs respectively multiple sclerosis tppp positive olg destruction well glioma loss tppp expression established anti proliferative potency tppp may raise influence cancer development recognition whereas much tppp could kill neurons loss keeps cells alive cancer could contribute understanding interrelationship tppp diseases expert commentary knowledge accumulated far underlines key roles multifunctional tppp physiological diverse pathological processes consequently validation drug target sorely needs new innovative strategy briefly reviewed
prosocial behavior crucial functioning societies however reliable scientific assessment understanding underlying structure still challenge integrated paradigms diverse disciplines identify reliable method independent subcomponents human prosociality participants performed game theoretical paradigms hypothetical distribution tasks commonly used behavioral economics completed interactive computer tasks self reports typically employed psychology four subcomponents prosociality identified exploratory factor analysis verified confirmatory factor analysis independent sample altruistically motivated prosocial behavior norm motivated prosocial behavior strategically motivated prosocial behavior self reported prosocial behavior altruistically motivated behavior related gender enhanced cognitive skills reduced negative affect study provides crucial step toward overarching framework prosocial behavior benefit future research predictors neural underpinnings plasticity human cooperation prosociality
schizophrenia bipolar illness two serious forms mental illness relatively recently almost nothing known molecular pathogenesis either illness single largest risk factor predisposes people schizophrenia bipolar illness genetic risk heritability high incidence significantly higher identical twins nonidentical twins despite decades work aimed identifying genes involved two illnesses virtually progress beenmade past decade knowledge technologies gained thehumangenome project ithas possible begin understand underlying genetics use new information begin effort discover new better medicines treat illnesses articlewilldescribe past decade work toward goal articulate promise thatnowexists andwhat still neededto bringdramatic andtangible change topatients scolnick thepath new therapies schizophrenia bipolar illness
paper compares forecasting performance three alternative factor models based business survey data industrial production italy first model uses static principal component analysis two apply dynamic principal component analysis frequency domain subspace algorithms state space representation respectively factors extracted business survey data included single equation predict industrial production index forecast results show three factor models better performance simple autoregressive benchmark model regardless specification estimation methods furthermore state space model yields superior forecasts amongst factor models
human activity recognition har important research area fields human perception computer vision due wide range applications applications include intelligent video surveillance ambient assisted living human computer interaction human robot interaction entertainment intelligent driving recently emergence successful deployment deep learning techniques image classification researchers migrated traditional handcrafting deep learning techniques har however handcrafted representation based approaches still widely used due bottlenecks computational complexity deep learning techniques activity recognition however approaches based handcrafted representation able handle complex scenarios due limitations incapability therefore resorting deep learning based techniques natural option review paper presents comprehensive survey handcrafted learning based action representations offering comparison analysis discussions approaches addition well known public datasets available experimentations important applications har also presented provide insight field first review paper kind presents aspects har single review article comprehensive coverage part finally paper concluded important discussions research directions domain har
manuscript ultrashort soliton pulse propagation nonlinear tunneling cubic quintic media investigated effect chirping propagation characteristics soliton pulse analytically investigated using similarity transformation particular investigate propagation dynamics ultrashort soliton pulse dispersion barrier chirp chirp free soliton investigating obtained soliton solution found chirping strong influence soliton dynamics pulse compression amplification two important dynamics chirped soliton cubic quintic media open new possibilities improve solitonic communication system moreover surprisingly observe dispersion well formed chirped case whereas barrier formed chirp free case certain applications construction logic gate devices achieve ultrafast switching
background objectivecolorectal cancer crc remains second deadliest cancer united states several screening methods exist however detection small polyps remains challenge optical coherence tomography oct demonstrated capable detecting lesions small mouse colon detection based measuring doubling mucosa thickness colon microvasculature may attractive biomarker early tumor development tumor vessels characterized irregular structure dysfunction goal develop endoscopic method detecting segmenting colon vessels using doppler oct enable future studies improving early detection development novel chemopreventive agents methodwe conducted vivo colon imaging azoxymethane aom treated mouse model colorectal cancer using miniature endoscope swept source oct system khz sweep rate applied kasai autocorrelation algorithm laterally oversampled oct scans resolve vascular flow mucosa submucosa vessels segmented applying series image processing steps intensity thresholding two dimensional matched filtering iii histogram segmentation resultswe observed differences vessels sizes spatial distribution mature adenoma compared surrounding undiseased tissue compared results histology also imaged flow four young mice two aom treated two control showing significant differences expected early carcinogen exposure also present flow images adenoma living mouse euthanized mouse demonstrate flow detected euthanasia conclusionwe present best knowledge first doppler oct images vivo mouse colon collected fiber based endoscope also describe fast robust image processing method segmenting vessels colon results suggest doppler oct promising imaging modality vascular imaging colon requires exogenous contrast agents wiley periodicals inc
predominant assumption contemporary political academic debates gender roles attitudes supporting women paid work among immigrants deep rooted stable time however actual work family orientations among immigrants rarely studied purpose article study extent pace immigrants general adapt attitudes towards women paid work prevail host countries cross national research strategy applied using european social survey rounds allowing compare analyse attitudes towards women paid work among foreign born individuals resident european countries results indicate immigrants attitudes towards women paid work highly structured institutional cultural context host country male female immigrants well immigrants without children adapt host country attitudes high pace
paper describes concept conversion movement float wave power plant characterize high force low speed energy high speed low force energy linear machine using gas springs wave power plant float moving slowly buoyancy force float raising wave gravitational force float wave sinking enormous enormous force combined movement presents much concentrated energy linear electric generator converts low speed high force ocean wave energy electrical energy direct conversion piston generator moving way float cost effective due large size expensive concept converting slow movement low frequency ocean energy faster movement high frequency reduce size generator using double gas spring presented
study systematically reviews research child maltreatment risk gambling problems adulthood also reviews adult problem gamblers risk abusing neglecting children multiple database searches conducted using pre defined search terms related gambling child abuse neglect identified unique references excluded studies report original research specifically measure child maltreatment gambling twelve studies included multivariable analysis childhood maltreatment exposure problem gambling identified six seven studies examining childhood sexual abuse four five examining physical abuse showed significant positive association abuse later gambling problems odds ratios sexual abuse physical abuse studies examining psychological maltreatment two three examining neglect identified positive associations problem gambling studies risks reduced eliminated controlling mental health disorders three studies measuring risk child abuse neglect among current problem gamblers suggest increased risk child physical abuse medical conditions indicative neglect although considerable amount variation among studies child abuse associated increased risk gambling problems gambling treatment providers ask maltreatment history part clinical assessment problem gamblers may likely physically abuse neglect children data limited child welfare professionals consider asking questions parental gambling assessing family risk elsevier ltd rights reserved
sleep circadian functioning particular interest researchers focused improving treatments psychiatric illness goal present paper highlight exciting research utilizes basic sleep circadian science building blocks intervention mood disorders reviewed evidence suggests sleep circadian systems disrupted mood disorders linked symptoms open systems modified focus interventions developed effectively treat sleep disturbance within mood disorders intimately linked mood improvements sleep associated improvements mood although significant positive treatment effects evident research needed fill gap basic understanding relationship sleep mood
algorithm design analysis one core courses undergraduates majoring computer science technology based practical teaching experiences paper carries concrete discussions several aspects teaching content teaching methods practical teaching forth combination several typical problems encountered teaching process
work present simulation results nitride based fin shaped field effect transistors finfets using technology computer aided design tcad device simulator finfet received attention applications replacing high electron mobility transistors hemts algan gan based devices outstanding electrical performances high carrier density high electron mobility two dimensional electron gas deg therefore algan gan based double heterojunction finfet finfet designed double deg layers improve state current however designed device critical problem suppressing enhancement phenomenon called two dimensional hole gas dhg formed opposite polarization charge deg compared algan gan based single channel finfet finfet current value algan gan based finfet similar value aln used increase value finfet obtained value value higher algan gan based finfet reason proposed aln gan based finfet improve aln gan based finfet higher value aln gan based finfet
myo inositol phosphatidylinositol play pivotal function many metabolic pathways impaired impact unfavorably human health review analyzes several experimental clinical investigations regarding involvement class molecules physiological pathological situations major focus thyroid central issues relationship phosphatidylinositol thyrotropin tsh signaling one hand phosphatydylinositol autoimmunity hand issues consequences malfunction receptors ones tsh tshr insulin insulin like growth factor igf connection serum tsh concentrations insulin resistance also covered insulin resistance metabolic syndrome allied disorders diabetes polycystic ovary syndrome pcos autoimmunity certain malignancies reciprocal links myoinositol promising therapeutic potential appreciation inositol pathways involved certain disorders mentioned review may stimulate researchers envisage additional therapeutic applications
empathy complex construct thought contain multiple components one popular measurement paradigm interpersonal reactivity index iri used extensively measure empathic tendencies schizophrenia research across four domains empathic concern perspective taking personal distress fantasy however recent meta analysis conducted four factors scale goal meta analysis examine self reported empathic tendencies factor iri people schizophrenia compared healthy controls literature search revealed eligible schizophrenia studies hedges standardized difference effect size calculated component using random effects meta analytic model compared healthy controls schizophrenia samples reported significantly reduced tendencies empathic concern perspective taking fantasy significantly greater tendencies personal distress duration illness significantly moderated results perspective taking longer duration exhibited greater deficits percent female significantly moderated results personal distress samples females exhibited reduced effect sizes future work needed examine impact heightened personal distress empathic tendencies abilities schizophrenia including possible role emotion regulation
purposechronic inflammatory disorders oral cavity periodontitis recently linked systemic immune activation since fungal oral infections yet studied respect aim study determine whether local inflammation caused oral fungal infection palatal tissue denture stomatitisds associated systemic inflammatory response question becoming essential population ages materials methodsperipheral blood patients control patients assessed flow cytometry determine lymphocyte monocyte profiles intracellular cytometric analysis carried establish cytokine production cells diagnosed based clinical symptoms swelling redness oral mucosa confirmed microbiological swabs fungal colonization candida species control group recruited denture users without clinical microbiological signs oral infections resultspercentages peripheral lymphocytes cells monocytes subpopulations similar studied groups exception median percentages cell subsets significantly lower patients control subjects reduction observed cell subset cell subset conclusionswhile associated local fungal infection overtly affect activation monocytes lymphocytes number cells significantly lower patients possibly indicating limited potential infection clearance denture using aging patients
families face genetic disease risk must learn grapple complicated uncertainties health future long term basis women undergo brca genetic testing describe uncertainty related personal risk well loved ones particularly daughters risk genetic counseling setting prime opportunity practitioners help mothers manage uncertainty moment also leave session uncertainty management theory umt helps illuminate various types uncertainty women encounter important role communication uncertainty management informed umt conducted thematic analysis genetic counseling sessions practitioners mothers risk carriers brca mutation five themes emerged represent communication strategies used manage uncertainty addresses myths misunderstandings misconceptions introduces uncertainty related science encourages information seeking sharing family medical history reaffirms validates previous behavior decisions minimizes probability personal risk family members risk findings illustrate critical role genetic counseling families managing emotionally challenging risk related uncertainty analysis may prove beneficial genetic counseling practice generations families high risk cancer must learn strategic approaches managing complex web uncertainty challenge lifetime
background negative effects stress pose one major threats health economic well individuals independently age cultural background nevertheless term stress globally used unlinked scientificevidence based meaning discrepancies scientific public stress knowledge focus concern little know relevant since misconceptions stress may influence effects stress management psychoeducational programs development best practices interventions study aimed analyze stress knowledge among canadian brazilian general public determine extent scientific popular views stress differ countries methods evaluated healthy participants years age recruited canada brazil assess stress knowledge questionnaire composed questions regarding stress concepts stress bad versus stress free life good factors capable triggering stress response novelty unpredictability low sense control social evaluative threat versus time pressure work overload conflict unbalance children used results canadian brazilian participants showed misconceptions stress factors capable triggering stress response however rate misconceptions higher brazil canada conclusion findings suggest lack public understanding stress science variance according country society psychoeducational programs vulnerability stress related disorder discussed
acute intermittent porphyria aip autosomal dominant disorder caused partial deficiency porphobilinogen deaminase pbgd third enzyme heme biosynthetic pathway affect autonomic peripheral central nervous system posterior reversible encephalopathy syndrome clinicoradiological entity characterized headache seizures altered consciousness visual disorder associated potentially reversible neuroradiological abnormalities predominantly parieto occipital lobes establishing accurate diagnoses patient asymptomatic family members aip involves identifying pbgd enzyme mutations directly study report year old woman acute intermittent porphyria presented radiological manifestations suggestive posterior reversible encephalopathy syndrome novel pbgd frame shift mutation base deleted resulting glutamine stop codon glnfs chinese family elsevier inc rights reserved
obesity diabetes osteoporosis become major public heath burden understanding underlying mechanisms pathophysiological process benefit treatment osteoblast lineage cells charge bone formation showed participate whole body energy metabolism study identify wnt beta catenin signaling osteoblasts could regulate global energy metabolism including glucose homeostasis fat accumulation energy expenditure mice lacking catenin specifically osteoblasts postnatally exhibit decreased bone mass increased glucose level decreased insulin production decreased fat accumulation increased energy expenditure osteocalcin supplement rescue impaired glucose balance improving insulin production influence abnormal fat accumulation energy expenditure osteoprotegerin opg overexpression exclusively osteoblasts catenin deletion mice normalize decreased bone mass also decreased fat accumulation increased energy expenditure effect beta catenin deletion opg overexpression osteoblasts global energy metabolism relation inguinal fat browning results suggest regulation bone energy metabolism fat accumulation mediated exclusively osteocalcin findings may provide new insight regulation bone fat accumulation energy metabolism elsevier inc rights reserved
background purposeperformance gambling tasks parkinson disease particular interest pathological gambling often associated dopamine replacement therapy patients aimed evaluate effects transcranial direct current stimulation tdcs right dorsolateral prefrontal cortex dlpfc modulating gambling behaviour methodswe assessed effects cathodal tdcs right dlpfc iowa gambling task patients compared sham stimulation conducted second experimental design assessing effects anodal tdcs right dlpfc resultswe observed cathodal tdcs right dlpfc increased iowa gambling task scores compared sham stimulation second experimental design find significant differences anodal sham tdcs conclusionscathodal tdcs right dlpfc possibly reduces pathological overdrive frontostriatal networks patients dopaminergic medication thus modulating impulsive risky decision making
problems existing methods production tracking site construction result schedule delays increased costs eliminate deficiencies autonomous production tracking analyzes real time production data proposed specific implementation proposed production tracking mechanisms developed large site construction plant australia process installation paper shows production model site construction always nonlinear outcome due presence variability systems periodic production target deviation schedule converges zero end production period downward trend followed designing plan buffers iii long term production performance site construction autonomously monitored controlled observing critical variables production paper provides manage site construction recommendations effective production tracking management models propositions research practical value used detect impending production shortfalls periodic targets short term adjust capacity parameters production targets long term planning elsevier rights reserved
paper uses pragmatic findings lessons learned three case studies deduce community based rainwater harvesting rwh innovative solution develop sustainable drinking water supply systems developing countries especially africa asia taking advantage traditional community based activities african asian villages water supply system significantly improved introduction implementation rwh systems furthermore sustainable safe water sources africa asia brought fruition transparent self regulatory management systems supported comprehensive design maintenance guidelines funded private public sources end potential rwh lead toward greater resilience sustainability investigated based case studies three successful demonstration projects africa asia paper identifies innovative solutions resolving technical economic social problems barriers preventing wide implementation rwh developing countries especially africa asia also recommends strategies promote rwh african asian villages include following implementation pilot projects local levels promotion education rainwater preservation harvesting levels education system innovation micro funding systems cooperation corporate social responsibility activities strategies promote implementation rwh mainstream high priority technique national regional global water strategies
work investigation design direct drive electrical generator seaquest concept converter presented involves sizing procedure innovative arc shaped electrical generator flux switching principle chosen thanks high torque density analysis optimization performance verification fea finally study suitable control strategies particular attention given specificities new particular generator presents non constant rotational speed reciprocating motion border effects arc shaped generator compared traditional rotating machine directly coupled shaft moved pendulum
environmental pollution caused inert anthropogenic stressors microplastics aquatic media constantly increasing proliferating use plastic products daily life plastic particles enter waters primary microplastics even though large scale plastic items plastic bottles bags represent highest percentage plastic waste degeneration also generates microparticles nanoparticles secondary microplastics modern sewage treatment plants require innovative ideas order deal man made problem state art technology offers approaches minimise amount microplastics aquatic systems technologies however either insufficient costly well time consuming cases conceptual idea presented apply innovative inorganic organic hybrid silica gels provide cost effective straightforward approach currently synthesis preorganised bioinspired compounds advancing order produce functionalised hybrid silica gels step gels ability remove stressors microplastics waste water means sol gel process bioinspired silane compounds currently permuted macromolecules examined respect properties fixation filter material order remove hydrophobic anthropogenic stressors sustainably reproduction biological systems plays significant role particular material sciences approach becoming increasingly important among concepts new biomimetic molecules form basis investigation innovative host guest relationships anthropogenic stressors environment implementation technical processes
simple mathematical model predicting crushing stress composite materials derived presented article present knowledge fracture mechanics strength materials used basis model fracture mechanics part analysis based energy release rate approach energy release rate proposed model determined approach energy release rate based mode opening tensile mode failure strength materials part analysis buckling theory used determine critical load fiber beams two engineering concepts combined form equation proposed model derived equation function materials properties geometric physical parameters composite materials calculated stresses derived equation compared experimental data technical research articles good agreements shown results encouraging recommendations future analysis different modes failure also presented article enables engineering designers predict crushing stress composite materials confidence makes work efficient reliable
objective higher rate depressive symptoms found among mothers children disabilities compared parents however lack study mothers children years age participating early intervention programs study aims fully describe extent mood disorders mothers including estimated prevalence severity factors associated maternal mental health using gold standard clinical diagnostic symptom measures test models associating depressive symptoms contextual factors child behavior methods cross sectional study conducted women least one child enrolled mothers interviewed completed reliable valid measures evaluate mental health health status family conflict parent child interaction self efficacy social support child behavioral problems hardship endangerment child disability descriptive statistics multivariate analyses performed results found participants met criteria major depressive episode mde sample reporting past episode endorsing recurrent episodes using ces assess depressive symptom severity approximately mothers screened clinically significant range using linear regression predict severity current depressive symptoms demonstrated current depression severity primarily predicted poorer maternal health status lower self efficacy past mde conclusions practice brief assessment maternal mood health self efficacy important factors assess evaluating support mothers children
partitioning bisphenol bpa geotextile gtx geosynthetic clay liner gcl investigated bpa distribution coefficients range geotextile component gcl entire gcl diffusion bpa gcl also investigated diffusion coefficient estimated bulk void ratio estimated parameters used study potential mass transfer bpa composite liner municipal solid waste landfill number scenarios results show hdpe geomembrane excellent diffusive barrier bpa advective transfer bpa composite liner needs limited minimizing number holes length wrinkles geomembrane elsevier ltd rights reserved
introduction centers disease control sexually transmitted diseases treatment guidelines recommend annual screening people living hiv plwh neisseria gonorrhoeae chlamydia trachomatis syphilis annual trichomonas vaginalis screening recommended hiv infected women study objective evaluate budgetary impact sexually transmitted infection sti screening hypothesized recommended sti screening costly would covered full insurers methods cost analysis evaluates charges reimbursement recommended screening stis study projects net yield reimbursement minus expenditures providing tests eligible plwh receiving care urban hiv clinic birmingham four scenarios evaluated net yield different laboratory providers rates compliance ryan white program fund availability examined results number patients receiving care hiv clinic august august female male patients annual screening gonorrhoeae trachomatis syphilis vaginalis would lead mean net loss respectively costly scenarios health system include use regional laboratory lack ryan white hiv aids program funding discussion compliance sti screening practices costly sustainability require critical analysis true costs cost effectiveness sti screening tests plwh providers policy makers insurers role ensuring provision evidence based services plwh
single stage converter designed wind energy conversion system wecs eliminates multistage operation link filter elements thus resolving size weight reliability issues simple switching strategy used control switches changes variable frequency output electrical generator constant frequency supply feed distributed electrical load grid addition modified random sinusoidal pulse width modulation rspwm technique developed designed converter make overall system efficient increasing generating power capacity reducing effects inter harmonics sub harmonics generated wecs technique uses carrier reference waves variable switching frequency calculate firing angles switches converter three phase output voltage converter close sine wave reduced thd comparison performance proposed rspwm technique conventional spwm demonstrated power generated turbine proposed approximately increased thd reduces voltage current respect conventional spwm
present study compared course parent report actigraphy derived sleep profiles year period school age children autism spectrum disorder typically developing children children sleep habits questionnaire nights actigraphy used assess sleep profiles parents also completed spence children anxiety scale social worries questionnaire bedtime routines questionnaire group differences parent reported sleep problems less pronounced follow compared baseline course objective sleep comparable groups significant reduction sleep duration time groups children autism spectrum disorder characterised significantly night night variability sleep quality across time points reductions time parent reported sleep problems significantly associated reduced anxiety reductions actigraphy derived sleep efficiency associated increased frequency maladaptive activities hour bedtime children without autism spectrum disorder
adult cell leukemia lymphoma atll rare often aggressive lymphoma causally linked chronic infection human cell lymphotropic virus type four subtypes described acute lymphomatous chronic smoldering acute lymphomatous subtypes comprise aggressive variants patients often require extensive supportive care designed manage hypercalcemia tumor lysis syndrome infectious complications prognosis poor aggressive subtypes treatment strategies traditionally focused antiviral therapy zidovudine interferon alfa well combination chemotherapy novel therapeutic approaches include monoclonal antibody therapy brentuximab vedotin anti chemokine receptor therapy mogamulizumab immunomodulatory therapy lenalidomide
background individuals restrictive eating disorders present morbid psychiatric disorders many attempt control symptoms using strenuous exercises increase caloric expenditure yoga offers safe avenue engagement physical activity providing outlet disease associated symptoms study sought examine use yoga practice outpatient setting impact anxiety depression body image disturbance adolescents eating disorders methods twenty adolescent girls recruited urban eating disorders clinic participated weekly yoga classes local studio addition standard multidisciplinary care yoga instructors underwent training regarding patient population participants completed questionnaires focused anxiety depression body image disturbance prior first class following completion classes results participants completed study statistically significant decrease anxiety depression body image disturbance seen including spielberger state anxiety mean scores decreased completion yoga classes adj anorexia nervosa scale adj scores beck depression scales adj weight shape concern scores adj adj respectively significant changes body mass index seen throughout trial conclusions yoga practice combined outpatient eating disorder treatment shown decrease anxiety depression body image disturbance without negatively impacting weight preliminary results suggest yoga promising adjunct treatment strategy along standard multidisciplinary care however whether yoga endorsed standard component outpatient eating disorder treatment merits study
santa bone symposium annual meeting healthcare professionals clinical researchers details clinical relevance advances knowledge skeletal diseases santa bone symposium held santa new mexico usa august program included plenary lectures oral presentations endocrinology fellows meet professor sessions panel discussions aimed provide ample opportunity interactive discussions among participants symposium topics included recent developments translation basic bone science patient care new clinical practice guidelines postmenopausal osteoporosis management patients disorders phosphate metabolism new emerging treatments rare bone diseases strategies enhance fracture healing update bone health extension community healthcare outcomes using teleconferencing platform elevate level knowledge healthcare professionals underserved communities deliver best practice care skeletal diseases highlights important clinical messages santa bone symposium provided herein faculty presenters
purpose evaluate health systems intervention increase adolescents receipt high quality sexual reproductive health care services methods quasi experimental design twelve high schools large public school district matched pairs within pair schools assigned condition control school shared geographic border intervention school five yearly surveys administered students randomly selected classes grades community based providers high quality sexual reproductive health care services listed referral guide use school nurses connect adolescents care results statistically significant effects found intervention school females three outcomes relative controls relative receipt birth control past year greater adjusted odds ratio aor confidence interval aor increases sexually transmitted disease testing treatment past year greater aor aor aor aor increases ever receiving hiv test greater aor among males intervention effects found conclusions school based structural intervention improve female adolescents receipt services published elsevier inc behalf society adolescent health medicine
paper deal relevance possibilities fuzzy relational databases regarding applications data managing manipulation authors presented contributions aspects approaches solving different tasks relational databases using fuzzy concept fuzzy logic fuzzy relations play crucial role overcoming limitations traditional relational databases including data representation date retrieval knowledge discovery data classification data mining approximate reasoning data intensive applications actually neglect facts data rules expressing real world always crisp paper presents perspectives fuzzy relational databases attempts apply concepts practice methods handling fuzzy data
background sex self injury become concept swedish society however largely unexplored area research yet conceptualized far accepted research field use sex way affect regulation known literature interviews young women sell sex compared direct selfinjury cutting burning skin aim study investigate self reported frequency sex self injury association sociodemographic factors sexual orientation voluntary sexual experiences sexual risk taking behaviors sexual physical mental abuse trauma symptoms healthcare psychiatric disorders non suicidal self injury methods representative national sample students year swedish high school mean age years included study study questionnaire based response rate mostly descriptive statistics used final logistic regression model made results sex self injury reported girls boys correlations sociodemographic factors noted group burdened experiences sexual physical emotional abuse non heterosexual orientation trauma symptoms non suicidal self injury healthcare suicide attempts depression eating disorders common conclusions sex used self injury seems highly associated earlier traumas sexual abuse poor mental health behavior needs conceptualized order provide proper help support highly vulnerable group adolescents
objective relation food allergies eosinophilic esophagitis eoe well established aeroallergens may also contribute development eoe however limited data support refute hypothesis objectives pilot study determine whether seasonal variation onset symptoms diagnosis eoe whether variations correlate specific pollen concentration within new york city methods performed retrospective chart review identify pediatric patients new york presbyterian weill cornell medical center diagnosed eoe sixty six patients identified excluded cases classified date initial symptoms date histologic diagnosis pollen counts certified new york city counting station percentage eoe cases collated monthly seasonally compared results seasonal variation onset symptoms diagnosis eoe highest number patients reporting onset symptoms eoe july september diagnosed eoe october december seasonal correlation peak levels grass pollen peak onset eoe symptoms highest july september diagnosis eoe peaked one season later conclusions study findings suggest correlation specific aeroallergens onset symptoms time diagnosis patients eoe
background registration trigger factors prodromal symptoms swelling localization therapeutic behavior gender specific differences largest cohort patients hereditary angioedema due inhibitor deficiency inh hae switzerland methods questionnaire survey within cohort study consenting eligible patients diagnosed hae according clinical history physical examination laboratory results including plasma values inh selected participant sent questionnaire assessing patients birthday sex date first symptoms diagnosis trigger factors prodromal symptoms frequency localization angioedema medication use morbidities clinical information collected center transmitted cohort database frequencies distributions summarized associations gender trigger factors prodromal symptoms localization angioedema assessed multivariate analyses correcting patients age results patients data patients available analysis fifty four percent female mean age diagnosis years mean age completing questionnaire women men symptomatic association remained correcting age diagnosis swelling episodes ranged episodes year swelling common among female among male age diagnosis inversely associated total number attacks one third patients danazol prophylaxis conclusion found large differences hae male female terms symptom number swelling episodes women affected intensity frequency angioedema episodes men danazol treatment remains widely used effective prophylaxis despite side effects new therapies selectively influence hormonal estrogen balance could open new therapeutic options mainly women maybe also men
present study evaluated effectiveness adults children together act raising safe kids parenting program violence prevention developing country specific objectives following compare parenting practices according mothers perceptions pre post intervention compare child behavior problems resources according mothers caregivers perceptions pre post intervention participants brazilian mothers year old children another caregiver child included study second informer child behavior mothers participated act program pre post intervention evaluations primary caregiver participated two evaluations child behavior results showed parenting practices improved significantly pre post intervention mothers primary caregivers reported significant decrease child behavior problems pre post intervention regard total behavioral difficulties emotional symptoms peer relationship scales mothers also reported significant decrease scores conduct problems hyperactivity improvements child behavioral capabilities regard prosocial behavior conclusion improvements parenting practices child behavior observed act program elsevier ltd rights reserved
new high accuracy current mode function generator circuit presented proposed computational structure designed implementing multitude circuit functions many applications vlsi designs realization original function generator based utilization new third order approximation function allows strongly reduce approximation error implemented functions circuit requires much smaller silicon area comparing similar previouslys reported circuits current mode operation independence output current function generator technological parameters temperature variations additionally increase overall circuit accuracy simulations confirm theoretical estimated results showing accuracy functional squaring core equal new proposed function generator based third order approximation function permits obtain wide output dynamic range maximal error implementing exponential function proposed function generator designed low voltage operation supplied
atlas experiment lhc collects billions events data taking year processes make available physics analysis several different formats even larger amount events addition simulated according physics detector models reconstructed analysed compared real events eventindex catalogue events production stage includes event identification parameters basic non mutable information coming online system references files contain event format plus internal pointers event within file quick retrieval eventindex record logically simple system hold many tens billions records equally important hadoop technology selected start eventindex project development proved robust flexible accommodate kind information insertion query response times acceptable continuous automatic operation started spring paper describes eventindex data input organisation hadoop explains operational challenges overcome order achieve expected performance
hole crack filling important issue depth image based rendering dibr algorithms generating virtual view images one view image one depth map available paper proposes priority patch inpainting algorithm hole filling dibr algorithms generating multiple virtual views texture based interpolation method applied crack filling inpainting based algorithm applied patch patch hole filling prioritized method selecting critical patch also proposed reduce computation time finally proposed method realized compute unified device architecture parallel computing platform runs graphics processing unit simulation results show proposed algorithm fold faster virtual view synthesis achieves better virtual view quality compared traditional dibr algorithm contains depth preprocessing warping hole filling
introduction traditional approaches clinical research yet failed provide effective treatments vascular dementia vad novel approaches collation synthesis data may allow time cost efficient hypothesis generating testing approaches may particular utility helping understand treat complex condition vad methods present overview new uses existing data progress vad research overview result consultation various stakeholders focused literature review learning group experience successful approaches data repurposing particular benefitted expert discussion input delegates international congress vascular dementia ljubljana october results agreed key areas could relevance vad research systematic review existing studies individual patient level analyses existing trials cohorts linking electronic health record data datasets illustrated theme case study existing project utilised approach conclusions many opportunities vad research community make better use existing data volume potentially available data increasing opportunities using resources progress vad research agenda exciting course approaches come inherent limitations biases bigger datasets necessarily better datasets maintaining rigour critical analysis key optimising data use
monte carlo method used qsar modeling dimeric pyridinium compounds acetylcholine esterase inhibitors qsar model developed series dimeric pyridinium compounds qsar models calculated representation molecular structure simplified molecular input line entry system one split training test set examined statistical quality developed model good calculated model dimeric pyridinium derivatives following statistical parameters training set test set structural indicators considered molecular fragments responsible increase decrease inhibition activity defined computer aided design new dimeric pyridinium compounds potential acetylcholine esterase inhibitors application defined structural alerts presented
introduction surgical template guide aimed directing implant placement tumor resection osteotomy bone repositioning using preoperative planning transferred actual surgical site precision safety reliability surgery improved however actual workflow surgical template design manufacturing quite complicated final clinical application areas covered major goal paper provide comprehensive reference source current future development template design manufacturing relevant researchers expert commentary paper aims present review necessary procedures template guided surgery including image processing visualization preoperative planning surgical guide design manufacturing addition template guided clinical applications various kinds surgeries reviewed demonstrated precision surgery improved compared non guided operations
objectives far fewer injury surveillance systems exist within community sport elite sport result epidemiological data sports injuries limited relevance community level sporting populations potential data community club based injury surveillance systems provide better understanding community sports injuries study aimed describe incidence profile community level australian football injuries reported using club based injury surveillance system design prospective epidemiological study methods sports trainers five community level australian football leagues recorded injury data two football seasons using club based system online surveillance tool developed sports medicine australia sports injury tracker used data collection injury incidence profile match injury rate reported results injury data players recorded season one players season two significant variability injury incidence across clubs however aggregated data consistent across football seasons average injuries per player per season match injuries per match exposure large proportion injuries occurred matches involved lower limb resulted contact conclusions data club based system provided profile injuries consistent previous studies community level australian football moreover injury incidence consistent studies using similar personnel record data however injury incidence lower reported studies using player self report healthcare professionals may underestimate true values sports medicine australia published elsevier ltd rights reserved
increasing penetration renewable energy sources inclusion additional features electrical networks become active every passing decade seen newer features electrical network emerging smart grid distribution systems becomes active grid tied inverters vital component active distribution systems acting interfaces distributed generators paper presents model predictive control mpc multifunctional inverter used power quality compensation non linear local loads grid integration solar photovoltaic generators including discrete nature switches power converter optimisation problem mpc reference current converter control generated using instantaneous power theory control simulated matlab simulink
osteoporosis significant public health problem associated increased fracture risk magnesium alloys promising biodegradable implant materials osteoporotic bone fracture repair due mechanical compatibility biological safety however degradation rate alloy match healing rate fracture growth rate new bone tissues order treat prevent osteoporosis enhance periimplant bone formation inhibit bone resorption slow degradation alloy herein developed novel bio inspired therapeutic coating strategy immobilizing strontium substituted hydroxyapatite nanocrystals bisphosphonate alendronate surface alloy aid polydopamine carboxymethyl chitosan cmcs novel functionalized coating improve corrosion resistance alloy also stimulate proliferation differentiation osteoblast cells due sustained release aln ions nanocrystals present coating strategy provides deep insights clinical repair osteoporosis associated fractures potentially extended design many orthopedic devices elsevier rights reserved
paper discusses non linear dynamical response shape memory non ideal oscillator non ideal excitation originates electric motor limited power supply driving unbalanced rotating mass restoring force provided shape memory device described thermomechanical model capable accounting hysteretic behavior via evolution suitable internal variable non linear dynamic response system investigated voltage control parameter numerical simulations show occurrence regular quasi periodic motions investigated via bifurcation diagrams phase plane portraits test used quantitative characterization chaotic responses computation basins attraction points strong dependence response small changes initial conditions along meaningful modifications competing basins variations control parameter finally variations mechanical thermal parameters pseudoelastic oscillator considered aim evaluating effects produced non ideal excitation source non linear dynamics shape memory device elsevier ltd rights reserved
design algorithmic framework using matrix exponentials time domain simulation power delivery network pdn framework reuse factorized matrices simulate large scale linear pdn system variable step sizes contrast current conventional pdn simulation solvers use fixed step size approach order reuse factorized matrices generated expensive matrix decomposition based proposed exponential integration framework design pdn solver matex flexible time stepping capability key operation matrix exponential vector product computed rational krylov subspace method improve runtime also propose distributed computing framework matex matex reduces krylov subspace generations caused frequent breakpoints large number current sources simulation virtue superposition property linear system scaling invariance property krylov subspace matex divide whole simulation task subtasks based alignments breakpoints among sources subtasks processed parallel different computing nodes without communication computation transient simulation final result obtained summing partial results among computing nodes finish assigned subtasks therefore computation model belongs category known embarrassingly parallel model experimental results show matex matex achieve around runtime speedups traditional trapezoidal integration based solver fixed time step approach
background increasing age biggest risk factor dementia alzheimer disease commonest cause pathological changes underpinning alzheimer disease thought develop least decade prior onset symptoms molecular positron emission tomography multi modal magnetic resonance imaging allow key pathological processes underpinning cognitive impairment including amyloid depostion vascular disease network breakdown atrophy assessed repeatedly non invasively enables potential determinants dementia delineated earlier therefore opens pre symptomatic window intervention may prevent onset cognitive symptoms methods design paper outlines clinical cognitive imaging protocol insight neuroscience sub study mrc national survey health development one oldest british birth cohort studies followed individuals since birth england scotland wales one week march individuals tracked waves data collection incorporating wide range health functional measures including repeat measures cognitive function aged years small fraction overt dementia estimates suggest similar individuals age group may preclinical stages alzheimer disease insight recruiting study members selected random attended clinical visit years relevant lifecourse data available describe sub study design protocol involves prospective two time point month data collection covering clinical neuropsychological beta amyloid positron emission tomography magnetic resonance imaging biomarker genetic information data collection started age aims completed age discussion integration data socioeconomic environment physical psychological cognitive function years coupled genetics structural molecular imaging intensive cognitive neurological phenotyping insight aims identify lifetime factors influence brain health cognitive ageing particular focus alzheimer disease cerebrovascular disease provide evidence base rational design disease modifying trials
examine case corporate spin reacquisition parent firm radically changed structure culture employing discourse lens study paradoxical tensions innovation key members talk paradoxical circumstances environment analysis develop concept tensional knots discursive formulations members construct tensions occurring gordian inseparable entanglements interdependence knotted tensions amplifying exacerbating attenuating improving effects one another different consequences innovative action specifically knotted tensions way members manage set counter intuitive logics serve justify courses innovative action inaction propose process model advancing understanding interlinked tensions complex ways current paradox theory allows conclude discussion contributions paradox theory innovative contexts along suggestions future research
background low testosterone levels men treated radical prostatectomy prostate cancer associated worse pathological stage outcomes long term data correlating preoperative testosterone levels outcomes presented methods total patients identified preoperative testosterone levels treated long term follow associations testosterone levels tumor stage gleason score time biochemical failure bcf assessed using pearson chi square test mantel haenszel test spearman rank correlation life table methods kaplan meier curves log rank test cox proportional hazards model appropriate testosterone analyzed continuous factor low versus normal testosterone levels results median testosterone level median age years median follow approximately years significant association testosterone values positive surgical margin well seminal vesicle invasion found patients testosterone level also showed higher percentage bcf time years difference statistically significant log rank test adjusted known predictors bcf gleason score pre prostate specific antigen seminal vesicle involvement positive surgical margin effect testosterone continuous predictor statistically significant conclusion longest follow date years correlating preoperative testosterone levels outcomes presented study low testosterone levels significantly associated positive surgical margin seminal vesicle invasion slightly higher bcf rates
continually increasing size geospatial data sets poses computational challenge conducting interactive visual analytics using conventional desktop based visualization tools recent decades improvements parallel visualization using state art computing techniques significantly enhanced capacity analyse massive geospatial data sets however strategies developed maximize utilization parallel computing resources support interactive visualization particular efficient visualization intensity prediction component lacking existing parallel visualization frameworks study propose data driven view dependent visualization intensity prediction method dynamically predict visualization intensity based distribution patterns spatio temporal data predicted results used schedule allocation visualization tasks integrated strategy parallel visualization system deployed compute unified device architecture cuda enabled graphical processing units gpus cloud evaluate flexibility strategy performed experiments using dust storm data sets produced regional climate model results experiments showed proposed method yields stable accurate prediction results acceptable computational overheads different types interactive visualization operations results also showed strategy improves overall visualization efficiency incorporating intensity based scheduling
systematic review evaluates long term dental arch changes rapid maxillary expansion treatment orthodontic patients constricted arches clinical trials assessed dental arch changes measurements dental casts cephalometric radiographs selected patients surgical simultaneous treatment active expansion period accepted electronic databases searched help senior health sciences librarian original articles retrieved selected abstracts references also scanned possible missing articles forty one articles met initial inclusion criteria later rejected lacked control group evaluated dental changes used semirapid technique also lacked reported measurement error remaining articles two report long term evaluation final four articles two measured changes dental casts two assessed changes radiographs one lateral cephalometric radiographs one posteroanterior radiographs similar maxillary molar cuspid expansion could found adolescents young adults significantly less indirect mandibular molar cuspid expansion attained young adults compared adolescents significant overall gain maxillary inandibular arch perimeter found adolescents transverse dental arch changes found puberty compared difference may clinically significant anteroposterior dental changes found lateral cephalometric radiographs
known objectiveprescription sequence symmetry analyses pssa ubiquitous tool employed pharmacoepidemiological research predict adverse drug reactions adrs several studies reported advantage pssa method applied large prescription database computational ease objective study validate new zealand prescription database potential source identifying adrs using pssa method methods analysed identified individual level prescription data people aged years period pharmaceutical collections supplied ministry health selected six positive controls previously investigated reported causing adrs six positive controls identified amiodarone repeated twice frusemide simvastatin lithium fluticasone amiodarone lithium reported induce thyroid dysfunction simvastatin reported cause muscle cramps fluticasone well documented cause oral candidiasis thyroxine identified marker drug treat hypothyroidism associated amiodarone lithium carbimazole identified marker drug treat hyperthyroidism associated amiodarone use quinine sulphate identified marker drug treat muscle cramps associated statins addition also analysed six negative controls unlikely associated adrs main outcome measure determine associations adrs using adjusted sequence ratios asr confidence intervals results discussionour analyses confirmed significant signal six positive controls significant positive associations noted amiodarone asr lithium chloride induced hypothyroidism asr amiodarone also strongly associated hyperthyroidism asr simvastatin associated muscle cramps asr fluticasone positively associated oral candidiasis asr frusemide associated hypokalaemia asr strong associations noted negative pairs important highlight pssa automatically controls confounding factors including unknown unmeasured confounding variables plus effect temporal trend prescriptions hence allows robust adr detection especially confounding factors difficult determine measure new conclusionnew zealand prescription database potential source identify adrs engaging pssa method could complement pharmacovigilance surveillance pssa important method post marketing surveillance monitoring adrs relatively short latency however predictive validity pssa compromised certain scenarios particularly sample size small new drugs market data sparse
instructive software developed programmed educational aid design distillation tower tray hydraulics using visual basic language user friendly software used educational aid undergraduate chemical engineering courses tool allows students study behavior distillation tower explore different mass transfer unit operation features students able perform many simulation exercises including tower overall interior design predict behavior undesired phenomena weeping flooding software environment facilitates students learning providing step step procedure instructions consistent standard course books wiley periodicals inc comput appl eng educ view article online doi
background dose sumatriptan efficacious fast acting acute treatment migraine dose sumatriptan may improve tolerability maintaining efficacy methods randomized double blind crossover study compared efficacy tolerability subcutaneous sumatriptan dfn sumatriptan adults rapidly escalating migraine attacks eligible subjects randomized treat attack dfn matching placebo autoinjector consecutively dfn autoinjectors consecutively second attack similarly alternative dose results proportions subjects pain free min postdose primary endpoint similar following treatment sumatriptan sumatriptan proportions subjects experiencing pain relief reductions migraine pain intensity relief nausea photophobia phonophobia sumatriptan sumatriptan similar mean scores satisfaction treatment mean number rescue medications used common adverse events doses triptan sensations paresthesia neck pain flushing involuntary muscle contractions neck incidence adverse events doses similar events total triptan sensations affected subjects dose subject dose subjects sumatriptan doses chest pain affected subjects treated dose subjects treated dose dfn serious adverse events conclusions dose sumatriptan dfn provided relief migraine pain associated symptoms comparable dose sumatriptan tolerability similar study medications dfn treatment associated fewer triptan sensations dose dfn dose sumatriptan may clinically useful alternative higher dose autoinjectors
fuel reforming attractive way improving performances internal combustion engine primary components reformed gas detailed knowledge component reformed gas essential judging making better use reformed gas well reforming technologies paper influences major combustibles reformed gas performances lean burn spark ignition natural gas engine investigated results indicate addition could improve cylinder combustion smooth engine operation increase engine thermal efficiency addition peaks cylinder pressure heat release rate increase flame development duration rapid combustion duration well covimep decrease however less effective compared influence engine thc emission insignificant addition tends increase engine emission remarkably owing quenching crevice effect tend worsen engine nox emission due increased cylinder temperature effect distinct simulation laminar flame speed manifests addition increase radical concentration hence improve flame propagation combustion process resulting improved laminar flame speed fuel air mixtures compare addition leads higher laminar flame speed addition whole investigation paper implies reformed gas effective improving engine combustion effective thermal efficiency effective elsevier ltd rights reserved
data clustering important step data mining machine learning especially crucial analyze data structures procedures recently new clustering algorithm known neutrosophic means ncm proposed order alleviate limitations popular fuzzy means fcm clustering algorithm introducing new objective function contains two types rejection ambiguity rejection concerned patterns lying near cluster boundaries distance rejection dealing patterns far away clusters paper extend idea ncm nonlinear shaped data clustering incorporating kernel function ncm new clustering algorithm called kernel neutrosophic means kncm evaluated extensive experiments nonlinear shaped toy datasets real datasets images used experiments demonstrating efficiency proposed method comparison kernel fcm kfcm kncm also accomplished order visualize performance methods according obtained results proposed kncm produced better results kfcm elsevier rights reserved
developmental needs infants first year life emphasised recent research variety sources highlighting crucial role early parent infant interaction plays infants identified significant risk maltreatment need adequate protection within time frame consistent developmental needs briefing paper describes new care pathway established within based social care team aims provide early identification intensive support timely assessment decision making group highly vulnerable pregnant women partners infants pathway care described case study presented illustrate care pathway mother referred eighteen weeks pregnancy supported post birth six months combination supporting structured professional judgement inclusion standardised tools training programme specifically developed high risk families suggests pre birth risk assessment process warrants evaluation
prevalence use herbal medicines rise across world especially amongst pregnant women fact draws attention many species commonly used pregnant women including tropaeolum majus tropaeolaceae also present inhibitory activity angiotensin converting enzyme ace herein investigated effects majus extract hetm fetal development evaluating relationship possible ace inhibitory activity pregnant wistar rats treated different hetm doses day gestational days rats sacrificed day pregnancy following parameters evaluated clinical symptoms maternal toxicity maternal body weight feed water intake maternal liver kidney ovary weights maternal ace activity aldosterone levels live fetuses mean dead fetuses percentage fetus weight fetal malformation pregnant rats treated high hetm doses showed significant reduction plasma ace activity accompanied decrease serum aldosterone levels moreover significant changes fetal development observed including growth retardation renal damage days gestation thus data presented demonstrate significant effects use hetm fetal development pregnancy
background purpose hospital acquired pressure injuries hapis continue persistent problem acute care arena purpose retrospective quality improvement study examine introduction nurse practitioners nps wound care consultants wccs without interventions impacted hapi rates community hospital methods retrospective comparison design used months hapi data may reported monthly national database nursing quality indicators ndnqi survey abstracted hospital records data included assessment patients divided two groups comparison months months hiring conclusions strong inverse correlation presence nps number patients hapis indicating hapi rates significantly lower nps took role wccs odds hapi occurring following introduction wccs odds previous years implications practice study findings suggest nps assuming leadership role wccs may instrumental decreasing hapi rates
studies management use water resources one focus several research looking alternatives use natural resources sustainability study aimed planning execution estimate economic return use rainwater washing vehicles agricultural machinery implements study conducted sector mechanization polytechnic school federal university santa maria march february roof agricultural mechanization sector catchment area five tanks liters installed underground water consumption reduced used liters water rainy intended proposed activities reservoirs largest investment accounting followed washing total costs total savings obtained monthly depending costs water system rainwater harvesting alternative reduce consumption water sources
background female sex workers fsw vulnerable population sexual violence poor sexual reproductive health outcomes sexual violence fsw widely studied gambia study report prevalence evaluate health issues correlated forced sex perpetrated clients fsw gambia secondly aim inform future research efforts improve health outcomes survivors violence methods cross sectional survey administered among fsw accrued combination chain referral venue based sampling gambia eligibility criteria included years old exchanged sex money goods favors past months results high prevalence sexual violence fsw gambia participants reporting client forced sex lifetime women reported forced sex client likely report symptoms depression aor unwanted pregnancy aor report difficult somewhat difficult access condoms aor compared women report forced sex client perpetrated forced sex also negatively associated receiving sexually transmitted infection sti test past months aor conclusion fsw experience sexual violence client likely experience poor sexual reproductive mental health outcomes responding sexual violence among fsw including providing survivors access post exposure prophylaxis emergency contraception mental health services must priority given prevalence forced sex links poor health outcomes efforts reduce sexual violence fsw vital strategy improve health safety fsw well impact spread hiv stis gambia
germline mutations pole pold shown cause predisposition colorectal multiple polyposis wide range neoplasms early onset colorectal cancer prevalent order find additional mutations affecting proofreading activity polymerases sequenced exonuclease domain patients multiple polyps early onset colorectal cancer phenotype without alterations known hereditary colorectal cancer genes interestingly none previously reported mutations pole pold found hand among genetic variants detected two stood putative pathogenic pole gene del valile first variant detected two families proven alter correct rna splicing contrarily valile detected one early onset colorectal cancer patient located right next exonuclease domain pathogenicity change suggested rarity bioinformatics predictions indicated functional assays schizosaccharomyces pombe first study functionally analyze pole genetic variant outside exonuclease domain widens spectrum genetic changes dna polymerase could lead colorectal cancer predisposition
background tight junctions tjs form barrier apical side neighboring epithelial cells bronchial mucosa changes integrity might play role asthma pathogenesis enabling paracellular influx allergens toxins microbes submucosal tissue objective regulation bronchial epithelial tjs cells cytokines involvement epigenetic regulation barrier function investigated methods expression regulation function tjs determined air liquid interface ali cultures control asthmatic primary human bronchial epithelial cells hbecs means analysis transepithelial electrical resistance paracellular flux mrna expression western blotting immunofluorescence staining results hbecs asthmatic patients showed significantly low integrity ali cultures compared hbecs healthy subjects cell numbers levels cytokines decreased barrier integrity ali cultures hbecs control subjects hbecs asthmatic patients induced physical separation tjs adjacent cells immunofluorescence staining molecules occludin zonula occludens observed expression histone deacetylases hdacs silent information regulator genes sirtuins sirts significantly high hbecs asthmatic patients significantly increased expression hdacs sirts role hdac activation epithelial barrier leakiness confirmed hdac inhibition improved barrier integrity increased synthesis molecules epithelium asthmatic patients level seen hbecs control subjects conclusion data demonstrate barrier leakiness asthmatic patients induced cells hdac activity inhibition endogenous hdac activity reconstitutes defective barrier increasing expression
epidemiologically based evidence demonstrated substantial number athletes exercisers injured year result physical disability well negative physical social psychological consequences accumulated research indicated prevalence sport physical activity related injuries varies based gender age group type sport level participation role team among considerations although physical causes primary contributors injury considerable number studies suggested psychological social factors also importance injury prevention rehabilitation among psychosocial factors investigated social support emerged significant buffering coping resource recovery process athletic injuries however research also indicated sources social support tend less frequently available athletes stages rehabilitation necessarily meet athletes expectations needs moreover studies suggested social support may detrimental effects certain circumstances coaches athletic trainers health care professionals aware complex forms influence develop implement injury rehabilitation processes based holistic approach order promote athletes recovery well
ability innovate important requirement many organisations despite pressing need selection systems healthcare focus identifying potential creativity innovation area vastly researched first step towards understanding might select creativity innovation paper explores use trait based measure creativity innovation potential evaluates efficacy use selection healthcare education study uses sample postgraduate physicians applying education training general practice participants completed two questionnaires trait based measure creativity innovation measure big five personality dimensions also rated assessors creative problem solving measured selection centre exploring construct validity trait based measure creativity innovation research clarifies associations personality creativity innovation particular study highlights importance motivation creativity innovation process results also suggest openness experience positively related creativity innovation whereas aspects conscientiousness negatively associated creativity innovation results broadly support utility using trait based measure creativity innovation healthcare selection processes although practically may best delivered part interview process rather screening tool findings discussed relation broader implications placing priority creativity innovation selection criteria within healthcare education training future
novel pursuit based approach presented investigate collective motions formations large number agents single integrator kinematics double integrator dynamics directed acyclic graphs dags agent pursues neighbors according directed acyclic graph agents without neighbors leaders based signal flow graph analysis mason rule necessary sufficient conditions derived bibo stability resulting pursuit systems moreover achievable collective motions formations analyzed adjusting set control parameters leaders keep stationary perform uniform rectilinear motions perform uniform circular motions finally simulations provided achieving static formation mimicking several complex collective behaviors observed nature formation vortex motions tornado motions elsevier ltd rights reserved
aim evaluate quality accuracy websites written public inflammatory bowel disease ibd crohn disease ulcerative colitis assess readability level methods google bing yahoo search engines searched independently three researchers december english language websites selected basis predetermined inclusion exclusion criteria researchers independently evaluated quality website using discern honcode instruments readability levels calculated using two formulas flesch kincaid grade level index coleman liau readability index agreement evaluators calculated using cohen kappa coefficient results eighty four websites finally identified scores varied minimum discern score maximum mean median interquartile range interquartile range iqr minimum score honcode maximum mean median iqr websites reviewed creators websites universities research centers foundations associations commercial pharmaceutical companies charities volunteer work non university educational bodies flesch kincaid grade level readability score mean coleman liau readability index score significant correlation found two readability scores overall agreement evaluators measured cohen kappa coefficient range rated good conclusion discern honcode scores websites varied readability levels websites public readability level study highlights areas need improvement development patient education online materials ibd
zooplankton communities morphological changes cladocera crustacea branchiopoda may resulting water pollution anthropogenic activities natural events removal vegetation cover urbanization agriculture sewage release accelerate eutrophication process aquatic environment present study seeks demonstrate occurrence morphological abnormalities cladocerans relate changes morphology species composition physical chemical parameters water samplings made monthly five stations sapucai river compartment furnas reservoir located state minas gerais brazil july february furnas reservoir intense occupation surrounding areas agriculture urban industrial activities installation net cage fish cultures contribute water quality deterioration cladocerans samples collected using suction pump plankton net mesh size concentrated volume measures physical chemical parameters water obtained horiba multi sensor surface water column density morphology cladocera made microscopy twenty three species cladocera recorded high organism densities chydoridae family species morphological abnormalities observed daphnia gessneri ceriodaphnia silvestrii bosmina longirostris bosmina tubicen chydorus pubescens highest densities pubescens abnormalities observed sampling stations littoral characteristics influences sewage release pubescens abnormalities observed classified two types type abnormality considered increase length intestine size intestinal loop whereas type considered occurrence intestine prolapse morphological abnormalities cladocerans described compared ones described literature results may observe abnormalities probably resulting continuous eutrophication process occurring reservoir due anthropogenic activities around reservoir decrease water volume reservoir caused unusual dry weather period region last years
article contribution modeling analysis cohesion strength saturated porous bodies drying processes dependence drying induced state stress overall reduced stress admissible stress moisture content discussed strength criterion proposed stating possible cracking material drying takes place regions reduced stress exceeds critical admissible value given moisture content numerical calculations drying induced stresses carried convectively dried kaolin cylinder regions possible material cracking within cylinder determined theoretical prediction possible cracking place material consistent experimental data previously presented authors
migraine third prevalent disease planet yet understanding mechanisms pathophysiology surprisingly incomplete recent studies built upon decades evidence adenosine purine nucleoside act neuromodulator involved pain transmission sensitization clinical evidence rodent studies suggested adenosine signaling also plays critical role migraine headache supported widespread use caffeine adenosine receptor antagonist several headache treatments review highlight evidence supports involvement adenosine signaling different forms headache headache triggers basic headache physiology evidence supports adenosine receptors critical adenosine receptor subtype involved headache pain adenosine receptor signaling may contribute headache via modulation intracellular cyclic adenosine monophosphate camp production amp activated protein kinase ampk activity neurons glia affect glutamatergic synaptic transmission within brainstem evidence supports study adenosine signaling headache potentially illuminates novel therapeutic target migraine
pathophysiologic mechanisms secondary brain injury intracerebral hemorrhage particular mechanisms perihematomal edema progression remain incompletely understood recently role spreading depolarizations secondary brain injury established ischemic stroke subarachnoid hemorrhage traumatic brain injury patients role intracerebral hemorrhage patients particular association perihematomal edema known total comatose intracerebral hemorrhage patients hematoma evacuation subdural electrocorticography performed studied prospectively hematoma evacuation subdural strip electrode placement performed within first patients electrocorticography recordings started surgery iqr lasted median per patient patients patients total spreading depolarizations observed spreading depolarizations common initial days peak incidence day median electrocorticography depression time longer previously reported min iqr min postoperative perihematomal edema progression patients significantly associated occurrence isolated clustered spreading depolarizations monitoring spreading depolarizations may help better understand pathophysiologic mechanisms secondary insults intracerebral hemorrhage whether may serve target treatment intracerebral hemorrhage deserves research
chernobyl nuclear accident occurred april resulted widespread long term contamination mainly due large territories populations live project initiated assess body burden health status limited radiation induced pathologies children living highly contaminated district belarus aim provide detailed information parents worried children health without intention quantifying radiation induced risk total children benefited check ups included approximately parameters repeated three times internal burden rather low children less health indicators reported paper global health status physical development frequencies thyroid modifications cardiac dysfunctions body burden density deposition appear strongly associated health indicators parameters quality living conditions rural urban residence appeared important aim project achieved results provided global overview health status level internal contamination children living contaminated territory years accident
building information modeling revolutionary technology process transformed ways projects designed analyzed constructed managed bim becoming better known established collaboration process construction industry many advantages using bim pre construction post construction phase construction industry increased building performance reduced financial risk reduced project schedule reliable accurate cost estimates program compliance optimized facility management maintenance paper tries identify current uses bim construction management developed countries china research conducted literature review case studies interviews
health care associated infection hai rates subject public reporting linked hospital reimbursement centers medicare medicaid services cms increasing pressure lower hai rates comes time advances clinical microbiology laboratory cml provide precise sensitive tests altering hai detection ways may increase reported hai rates review changing cml practices impact hai rates financial implications hai metrics may produce pressure change diagnostic testing practices finally provide suggestions respond rapidly changing environment
gully erosion represents one significant types land degradation mediterranean areas giving place important site effects paper second order gully located spain analyzed along gully cross sections established measured leica tcrm laser total station approximately every months sections located variable distance placing areas active erosion evident total field measurements carried geometric characteristics cross sections obtained morphometric analyses carried main gully tributary reach applying empirical relationship channel length eroded volume morphometric variables gully sections combined two dimensionless groups morphological similarity different linear erosion land forms rills ephemeral permanent gullies obtained coefficient variation calculated volumes used compare instability main gully tributary reach finally hydraulic geometry gully assessed calibrating three empirical power equations relate bankfull discharge mean flow velocity cross sectional depth width hydraulic characterization main gully tributary reach investigated field survey different behavior detected hydraulic analysis also demonstrated higher values discharge provide better predictions flow velocity size main tributary gullies affects discharge width relationship gully depth variable predicted highest accuracy elsevier rights reserved
paper experimental analysis power harvesting mechanical vibration vehicle studied using quickpack smart materials piezoelectric effect finite element ansys method ansys fem applied explore required mechanical structure modal harmonic analysis electrical feature output voltage admittance experimental platform consists shocker lever simulated periodical oscillation vehicle vibration evaluating conversion efficiency mechanical energy electrical energy loading experiments power generation electromechanical coupling characteristics smart materials investigated via proposed testing circuit also various electrical output loadings specified within resistance similar omega experiment analysis power harvesting test buck converter output terminal processed obtain spectrum analysis output voltage within vibrating frequencies controlled electromagnetic shaker based comparison ansys fem spectrum analysis optimal results mechanical oscillating quantities verified maximum output voltage quickpack nqn material hence optimum power harvesting smart material maximum output power vibration vehicle
charlotte bronte jane eyre fanny fern ruth hall inscribe possibility personal agency textual passages describe border spaces movement margin periphery inside outside departure arrival authors employ architectural portals windows doorways gates stairs hallways illuminate array physical psychic socio cultural spaces convey fluid sense truth knowledge gained experience truth represented within subjective lens different positions protagonists assume way insertion autobiographic resonances fiction charlotte bronte fanny fern invert public private spheres thereby creating strategy personal agency emphasis mobile independence woman sit well many nineteenth century critics responded adversely implied expansion gender roles ultimately charlotte bronte fern method encoding threshold images subjective significance create conceptual space affords possibilities resistance social oppression
bioprinting emerging technology allows assembling living non living biological materials ideal complex layout tissue maturation bioprinting aims produce engineered tissue organ mechanized organized optimized manner various biomaterials techniques utilized bioprint biological constructs different shapes sizes resolutions need systematically discuss analyze reported strategies employed fabricate constructs identified discussed important design factors bioprinting namely shape resolution material heterogeneity cellular material remodeling dynamism design factors represented corresponding process capabilities printing parameters process design map inspire future biomaterials research aspects design considerations data processing bio ink formulation process selection discussed various printing crosslinking strategies relevant applications also systematically reviewed categorized general bioprinting strategies including direct bioprinting process crosslinking post process crosslinking indirect bioprinting hybrid bioprinting opportunities outlook bioprinting highlighted review article serve framework advance computer aided design bioprinting technologies
conformational states adopted polymer chain water result delicate balance intra molecular water mediated interactions using explicit representation solvent however computationally expensive often necessary turn implicit representations present systematic derivation implicit models water study effect simplifying representation solvent conformations hydrophobic homopolymers varying length starting explicit coarse grained single site water model develop implicit solvent model reproduces free energy contact pair two hydrophobic monomers implicit solvent model captures free energy contact pair minima desolvation barrier solvent separated minima finally consider vacuum simulations generate potentials mean force polymers various lengths explicit water implicit solvents vacuum using umbrella sampling replica exchange molecular dynamics simulations surprisingly vacuum simulations outperform implicit solvent simulations implicit model involving desolvation barrier producing spurious extended polymer conformations wiley periodicals inc
cogging torque known disadvantage surface permanent magnet spm machines especially equipped open stator slots possible strategy reduce cogging torque use suitably designed non isotropic magnetic wedges design wedges cogging torque minimization requires genetic optimization approach done previous works using finite element analysis fea simulations predict cogging torque machine design explored leading time consuming optimization process paper optimization performed using analytical method compute cogging torque shown optimization process based analytical formula cogging torque prediction leads result fea based procedure significant reduction computational burden
study proposes new time domain fault location method based impulse response image power system proposed algorithm captures electrical image power system normal operation injecting train impulses following fault detection updated electrical image acquired compared normal operating image comparison images time domain permits estimation distance fault performance proposed method evaluated distribution system modelled power systems computer aided design electro magnetic transient design control pscad emtdc moreover laboratory field tests overhead line carried verify validate model accuracy performance results show considerable improvement accuracy fault distance estimation compared existing algorithms relevant advantage proposed method high immunity ground resistivity fault resistance fault type location distribution system
paper brings attention new nonlinear mathematical model hydro turbine governing system surge tank nonlinear mathematical model described state space equations composed francis turbine system electrical generator system conduit system governor system furthermore nonlinear dynamical behaviors system different parameters studied exhaustively including bifurcation diagrams time waveforms phase orbits poincare maps spectrograms power spectrums fortunately interesting phenomenons found numerical simulation results important analyses supply theory bases designing running hydro turbine governing system elsevier inc rights reserved
study situated within existential narrative theoretical framework examine impact career threatening injury professional ice hockey players well career construction professional ice hockey culture construed privileged space characterised hegemonic masculinity fierce competition well high risk behaviours often resulting sports injuries paper analyse two players life stories particular focus injury boundary situation involving social temporal breakdown evaluation meaning sporting life projects emergent narratives surrounding existential themes loss meaning loneliness face injury analysed connection players search authenticity realignment self concept player developed resistant narratives dominant ethos professional sport order restore well sense self relational aspects injury highlighted practical recommendations
paper present application soft computing methods problem wimax network planning geographical information systems gis optimizes performance network coverage quality service investment costs number base stations sectors pre processing procedure using latest results parallel random forest classification algorithm determine valid positions base stations terrain gis proposed based upon positions design generalized mathematical model taking account obstacles path loss calculation process order generate optimal solutions model hybrid algorithm greedy btp improved particle swarm optimization incorporated parallel computing presented experimental validation proposed method comparison relevant ones performed elsevier inc rights reserved
cloud computing uses outsourcing remote processing applications first appeared ten years ago cloud computing built research virtualization distributed computing utility computing web services reduces information technology overhead starting new business accessed anywhere one concepts used constructing cloud computing virtualization security risks specific cloud key drawback adopting cloud computing security since clients use someone else cpu hard disk processing storing data paper proposes security framework secure virtual machine images virtualization layer cloud environment securing virtual machine image significant probably affect security cloud computing
purpose review compare contrast national asthma guidelines global initiative asthma gina strategy asthma management prevention recent findings common goal gina national asthma guidelines improve asthma care using best evidence available published data evidence based approach evolved initial perspective expert opinion evolution always considered breadth asthma phenotypes gina national guidelines differ number ways gina reviews available data updates core document recommendations based latest data yearly basis offer local regional national guidelines materials needed knowledge mobilization remains purview organizations structure implement locally appropriate guidelines summary gina national guidelines furthered asthma care narrow care gap known asthma care delivered hopefully directed personalized manner well gina national guidelines helped shape direction research future benefit children families
paper addresses development supervision control software multipurpose three tank system teach control engineering fundamentals laboratory equipment consists three series tanks industrial instrumentation design requirements determined users perform academic activities area process control requirements software include data acquisition clear visualization components involve process communication different actuators alarm generation recorder data logger selection different control strategies technological systems plc industrial controller friendly human machine interface equipment used teach undergrad courses grad courses industrial training research projects ifac international federation antomatic control hosting elsevier ltd rights reserved
current study examined relationship early language ability autistic like traits adulthood utilising data participants longitudinal study general population language performance years measured language development survey lds years participants completed autism spectrum quotient vocabulary size years negatively associated total score well scores communication social skills subscales adults late talkers also likely high scores communication subscale first study show association early language ability autistic like traits adulthood
radiation hardness different samples ics vary greatly lot lot depending year country production however assumed radiation hardness samples lot new chip uniformity test method based ionization response comparison offered
tremendous growth economic activity across globe placing pressure natural environmental resources rising concern environment response global warming driving thinkers seek sustainable solutions real estate industry significant contributor global warming due extensive emissions greenhouse gases ghgs energy use buildings indicates real opportunity develop green buildings country concept green building integrates interests aspects sustainability emphasising reduction environmental impacts holistic approach land building uses construction strategies many professionals associated building industry follow different guidelines depending upon need project study done check awareness knowledge contractors areas green buildings sustainable development study conducted delhi ncr regions methods used data collection interview schedule group discussions revealed knowledge contractors low areas green buildings sustainable development findings reveal need trained professionals construction green buildings
impact legal status romantic relationships adequately explored literature based video phone interviews undocumented activists ages years old research examines legal status affects romantic relationships undocumented women men hegemony traditional dating scripts made difficult without legal status participate gender roles consistent stereotypical male female roles dating often attribute power responsibility men women experienced slight advantage traditional notions courtship require provide resources required dating money transportation contrast commonly expected men contrast women noted difficulties disclosing legal status depending partners everyday activities additionally men women faced exclusion inhibited dating lives direct result legal status suggests impact legal status may salient stages family formation undocumented young adults experiencing distinct phenomenon compared documented native born peers
background objective first class oral pharmacologic treatments overactive bladder oab antimuscarinics associated poor persistence anticholinergic adverse events increased anticholinergic burden acb risk cognitive impairment mirabegron adrenoceptor agonist oral treatment contribute acb early evidence improved persistence objective analysis assess cost effectiveness mirabegron oab six antimuscarinics methods markov state transition model assessed commercial health plan medicare advantage perspectives year time horizon oab patient population transition probabilities five micturition five incontinence severity states derived network meta analysis trials oral oab treatments therapy beginning oral oab agent could discontinue switch another oral agent could followed tibial nerve stimulation sacral neuromodulation onabotulinumtoxina primary outcome cost per quality adjusted life year qaly utilities mapped incontinence micturition frequencies well demographics based analysis data large healthcare system elevated acb associated increased healthcare utilization probability cognitive impairment results commercial medicare advantage perspectives mirabegron clinically effective treatment oxybutynin least expensive tolterodine immediate release also cost effectiveness frontier analysis estimated costs per qaly mirabegron commercial health plan medicare advantage perspectives respectively compared tolterodine antimuscarinics dominated conclusions analysis estimated mirabegron cost effective treatment oab commercial health plan medicare advantage perspectives due fewer projected adverse events comorbidities data suggesting better persistence
increasing complexity data structures computer architectures performance applications needs fine tuning order achieve expected runtime execution time performance tuning traditionally based analysis performance data analysis results may accurate depending quality data applied analysis approaches therefore application developers may ask trust analysis results paper introduces research work performance optimization memory system focus cache locality shared memory memory locality distributed shared memory quality data analysis guaranteed using real performance data acquired runtime application running well established data analysis algorithms field bioinformatics data mining verified quality proposed approaches optimizing set benchmark applications experimental results show significant performance gain
internet things iot projected soon interconnect tens billions new devices large part also connected internet iot devices include high end devices use traditional operating systems oss linux low end devices due stringent resource constraints limited memory computational power power supply however large scale iot software development deployment maintenance requires appropriate build upon paper thus analyze detail specific requirements satisfy run low end iot devices survey applicable oss focusing candidates could become equivalent linux devices one size fits open source low end iot devices
rail rail operational amplifier designed minimum variation input stage transconductance standard cmos technology design transconductance maintained approximately constant independent operation region input transistors saturation weak inversion regions unlike conventional methods rail rail designs two complementary differential pairs used work using single input pair sensitivity mismatches pmos nmos input transistors eliminated monte carlo simulation run ensure mismatch insensitivity simulation results show input stage transconductance deviation input common mode voltage varies rail rail less typical conditions degrees temperature varies degrees degrees variation exceed furthermore variations two long channel short channel cases respectively proves introduced circuit works properly regardless channel length input pair elsevier ltd rights reserved
sleep disruptions represent core feature bipolar disorders widely studied use actigraphy objective measure motor activity sleep finding objective outcomes reliably measure sleep bipolar disorders essential developing better therapies improving follow monitoring strategies aim understand role actigraphy objective measure sleep bipolar disorder undertook systematic review meta analysis studies using actigraphy detect changes activity sleep patterns bipolar patients versus healthy controls primary outcome measures analyses activity mean sleep duration secondary outcomes analysed sleep onset latency sleep efficiency time awake sleep onset thirteen studies comprising subjects met quality criteria inclusion results show decrease activity mean altered pattern sleep bipolar patients analyses suggest results might generalized bipolar condition underlies manic depressed episodes well euthymic phases study highlights role actigraphy important objective tool ambulatory monitoring sleep activity bipolar disorders elsevier ltd rights reserved
background next generation sequencing ngs revolutionized research carried many areas biology medicine however analysis ngs data remains major obstacle efficient utilization technology requires complex multi step processing big data demanding considerable computational expertise users substantial effort invested development software dedicated individual analysis steps ngs experiments insufficient resources currently available integrating individual software components within widely used bioconductor environment automated workflows capable running analysis types ngs applications start finish time efficient reproducible manner results address need developed bioconductor package systempiper extensible environment building running end end analysis workflows automated report generation wide range ngs applications unique features include uniform workflow interface across different ngs applications automated report generation support running command line software local computers computer clusters flexible sample annotation infrastructure efficiently handles complex sample sets experimental designs simplify analysis widely used ngs applications package provides pre configured workflows reporting templates rna seq chip seq var seq ribo seq additional workflow templates provided future conclusions systempiper accelerates extraction reproducible analysis results ngs experiments combining capabilities many bioconductor command line tools makes efficient use existing software resources without limiting user set predefined methods environments systempiper freely available common operating systems bioconductor http bioconductor org packages devel systempiper
field programmable analog arrays fpaa offer electronic equipment designers new possibilities quick interactive flexible design process simple verifying prototyping modifying many circuit solutions detailed research results selected parameters ane device delivered anadigm presented features mentioned data sheets noted analyzed concerning device input output filters based examined ane device example application automatic gain control agc circuit built advantages design obtainable parameters problems involved application fpaa presented paper
paper introduces system automatic evaluation correctness originality source codes submitted students enrolled courses dealing computer programming automatic correctness checking consists searching plagiarisms assignments submitted earlier checking correct implementation algorithms user interface implemented moodle module using plagiarism api complete system published gplv license therefore learning institutions use well
french ministry ecology sustainable development energy decided launch scientist participatory initiative field water initiative brings general public scientist community together aim improve knowledge field water general public invited take pictures film conduct field experiments witness hydraulically interesting processes propagation deformation surface waves rivers well oceans river bed evolutions corresponding videos refer common exceptional events also constitute precious first hand documents documents produced commented scientists utilized publishing purposes answer initiative based collaborative tool wikhydro wiki ministry ecology sustainable development energy water field opened internet contains pages videos first feedback months launch positive encouraging videos illustrating physical phenomena already raised curiosity scientists follow initiative use videos recorded floods storm surges quantify data water levels water velocities answer response connected society uses new technologies information communication technologies ict internet smartphones social networks smart sensors citizen provides geo referenced data becomes major actor territory qualitative quantitative big data mining contribute improve public policies fields prevention forecasting resilience territories
patients history food allergy food intolerance common pediatric population encountered frequently perioperative setting pediatric anesthesiologists perioperatively food allergy present spectrum ranging minor acute urticaria severe hypovolemia anaphylactic shock allergy foods including fruits fish egg soy peanut concerning potential cross react perioperative medications little anesthesia literature focuses perioperative management children food allergies educational review provide brief overview classic immunoglobulin ige mediated food allergies less common non ige food allergies present perioperative considerations patients audio summary topic included supplementary audio
emergence altruistic behavior infants fosters social development supports involvement society altruistic tendencies intended benefit others apparent rewards also useful social robots designed used households yet make robots capable learning help others infants important understand mechanisms motives responsible development altruistic behavior understanding mechanisms behind early development pro social behavior would great contribution field developmental psychology ends hypothesize infants months age help others minimize differences predicted actions observations minimize prediction errors evaluate hypothesis created computational model based psychological studies implemented real simulated robots system first acquires sensory motor representation interacting environment using experience system recognizes predicts others actions uses prediction estimate prediction error experiments demonstrated robots could spontaneously generate helping behaviors motivated minimization prediction errors
oxidative stress shown play contributory role pathogenesis rheumatoid arthritis recent studies provided evidence antioxidant properties spa therapy purpose study investigate whether spa therapy saline balneotherapy influence oxidant antioxidant status patients assess clinical effects spa therapy investigator blind randomized controlled trial randomly assigned patients ratio spa therapy plus standard drug treatment spa group standard drug treatment alone control group spa group followed week course spa therapy regimen consisting total balneotherapy sessions thermal mineral water pool degrees min every day except sunday clinical biochemical parameters assessed baseline spa therapy weeks clinical parameters pain intensity patient global assessment physician global assessment health assessment questionnaire disability index haq disease activity score joints based erythrocyte sedimentation rate das esr oxidative status parameters malondialdehyde mda nonenzymatic superoxide radical scavenger activity nssa antioxidant potential aop superoxide dismutase sod nssa levels increased significantly spa group control group trend favor spa therapy improvements nssa levels compared control significant clinical improvement found spa group compared control terms patient global assessment physician global assessment function haq disease activity das esr swollen joint count trend toward improvement pain scores spa therapy saline balneotherapy exerts antioxidant effect patients reflected increase nssa levels spa therapy whether antioxidant effect contributes clinical improvements observed remains verified
though muscle characteristics second half gestation closely relate quantity quality postnatal muscle far fewer studies examined breed differences prenatal sheep muscle study seeks better understand anatomic prenatal muscle differences underpinning mechanisms two contrasting sheep breeds total sheep fetuses including texel pronounced muscularity ujumqin indigenous fat tailed sheep characterized hardiness fetuses aged five time points embryonic day gestation sacrificed organs muscles dissected anatomical locations right side animal whole texel fetuses weighed especially fold heavier internal organs age matched ujumqin fetuses texel fetuses also contained muscle including aggregate excised muscles muscle proportion similar larger similar total muscle fibers greater muscle size loin muscle area lower proportion type muscle fibers texel ujumqin anatomical locations notably texel fetuses sharply decreased myofiber number significantly augmented fiber size accompanied molecular events resembled myoblast fusing ujumqin sheep indicate period pivotal texel myoblast fusing altogether results suggest comparing obese animal muscular superiority lean breed largely establishes middle gestation although share similar regulatory gene network present study provides novel insight mammalian myogenesis elsevier rights reserved
study proposes synthesizing high strength polyester hspet fibers polypropylene fibers form hspet fasciated yarns tested tensile strength exposed radiations yarns made geogrids geogrids tested administering single multi rib tensile method evaluated mass per unit area installation damage test results show tensile strength elongation fascinated yarns decrease result exposure geogrids composed fascinated yarns unable evenly distribute force installation damage hspet geogrids greater traditional geogrids cases applications result hspet geogrids reformed improve inferior performances
purpose study examine effectiveness review question content object advanced organizer used prior knowledge activation introductory computer programming students engagement using strategies examined reach primary findings content object advanced organizer activate prior knowledge used new programming concept learnt review questions programming concepts solutions designed encourage paper pen method findings shown similar performance post test outcome study showed useful foster better learning programming published elsevier ltd
smart home ambient intelligence ambient assisted living intensively researched decades although rural areas important potential market represent territory countries around million inhabitants currently lack applicable aal solutions paper discusses theoretical foundations aal rural areas discussion underlined achievements empirical field study casa vecchia carried four year period rural area austria major goal casa vecchia evaluate feasibility specific form aal rural areas bringing aal technology homes elderly rather moving seniors special equipped care facilities casa vecchia project thoroughly investigated possibilities challenges drawbacks aal related specific approach findings promising somewhat surprising indicate technical interactional socio psychological research required make aal rural areas reasonable future
dynamic projection mapping moving objects attracted much attention recent years however conventional approaches faced issues target objects limited rigid objects limited moving speed targets paper focus dynamic projection mapping onto rapidly deforming non rigid surfaces speed sufficiently high human perceive misalignment target object projected images order achieve projection mapping need high speed technique tracking non rigid surfaces still challenging problem field computer vision propose deformable dot cluster marker ddcm novel fiducial marker high speed tracking non rigid surfaces using high frame rate camera ddcm three performance advantages first detected even strongly deformed second realizes robust tracking even presence external self occlusions third allows millisecond order computational speed using ddcm high speed projector realized dynamic projection mapping onto deformed sheet paper shirt speed sufficiently high projected images appeared printed objects
closed plasma overcome difficulties maintaining plasma excessive energy consumption open environment plasma stealth technology closed plasma generator designed using microsecond pulse generator argon working gas discharge experiments carried low pressure environment emission spectrum different position discharge chamber measured using collisional radiative modal crm distribution plasma parameters studied given electron temperature density specified discharge parameters corresponding population distribution could obtained crm comparing line ratio argon levels acquired crm line ratio spectrum measured plasma parameters confirmed obtaining minimum difference value using line ratio argon crm range electron density similar calculating error analyzed results reveal electron density closed plasma reaches magnitude shows gradient distribution small variational amplitude distribution beneficial application plasma stealth
background skin injuries common among neonatal intensive care unit nicu patients may lead significant complications standardized methods preventing detecting treating skin injuries needed purpose aim project standardize assessment documentation tracking skin injuries among hospitalized neonatal patients determine incidence pressure ulcers patient population methods creation interdisciplinary skin team identify skin injuries weekly skin rounds assessment patients least twice daily presence skin injuries interventions implemented upon identification skin injury pressure ulcers stage assessed wound ostomy nurses findings total nicu patients hospitalized assessed july december initiation skin rounds baseline incidence pressure ulcers increased per patient days per patient days reflecting improvement detection reporting common skin injuries detected included erythema skin tears ecchymosis common cause injuries medical devices implications practice dedicated skin team improve detection reporting skin injuries among nicu patients determination incidence pressure ulcers population critical develop targeted interventions implications research research needed determine effective interventions prevent treat skin injuries among hospitalized neonates
schizophrenia research plagued enormous challenges integrating analyzing large datasets difficulties developing formal theories related etiology pathophysiology treatment disorder computational psychiatry provides path enhance analyses large complex datasets promote development refinement formal models features disorder presentation introduces reader notion computational psychiatry describes discovery oriented theory driven applications schizophrenia involving machine learning reinforcement learning theory biophysically informed neural circuit models
background emotion regulation skills questionnaire ersq comprehensively assesses nine aspects emotion regulation skills awareness clarity sensation understanding compassionate self support modification acceptance tolerance readiness confront however unknown levels emotion regulation skills various mental disorders cross cultural validity developed japanese version ersq examined validity reliability clinical non clinical populations methods internet based survey participants mdd sad ocd comorbid mdd anxiety disorder comorbid anxiety disorders non clinical sample answered ersq diagnostic status measures mindfulness emotion regulation behavioral activation psychological distress life satisfaction results confirmatory factor analysis cfa replicated theoretical nine factor structure original ersq higher order factor analysis model assuming two second order factors nine first order factors also showed adequate fit data suggesting factorial validity scale analyses multi group cfa indicated equivalence factor loadings across clinical non clinical subsamples levels internal consistency time stability sufficient convergent validity scale also confirmed external criteria character emotion regulation skills diagnostic group depicted limitations internet survey samples limited disorders self reported diagnoses may limit generalizability conclusions japanese version ersq showed adequate reliability validity
paper presents machine learning classifier computations performed standard sram array stores machine learning model peripheral circuits implement mixed signal weak classifiers via columns sram training algorithm enables strong classifier boosting also overcomes circuit nonidealities combining multiple columns prototype sram array implemented cmos process demonstrates ten way classification mnist images using image pixel features downsampled yields baseline accuracy sram mode bit cell read write prototype operates mhz classify mode operates mhz generating classification every cycle accuracy equivalent discrete sram digital mac system system achieves ten way classification energy per decision lower discrete system standard training algorithm lower discrete system proposed training algorithm
phosphodiesterase isoenzymes inhibitors pde first line therapy erectile dysfunction constant discoveries nitric oxide cyclic guanosine monophosphate cgmp cell signaling pathway smooth muscle control urogenital tracts ugts make pde promising pharmacologic agents benign urological diseases article reviews literature contains previously unpublished data characterizations activities pde inhibitors treating urological disorders scientific discoveries improved understanding cell signaling pathway cgmp mediated relaxation ugts moreover clinical applications pde widely recognized demand pde efficacious cases daily dosing combination testosterone recommended refractory cases soluble guanylate cyclase sgc stimulators also promising role management severe conditions pde also first rehabilitation strategy postoperation postradiotherapy prostate cancer patients pde especially combined adrenoceptor antagonists effective benign prostatic hyperplasia bph except maximum urinary flow rate max tadalafil recently proved bph without furthermore pde currently various phases clinical preclinical researches promising potential urinary genital illnesses priapism premature ejaculation urinary tract calculi overactive bladder peyronies disease female sexual dysfunction inhibition pde expected effective strategy treating benign urological diseases however clinical studies basic researches investigating mechanisms pde disorders ugts required
optical time stretch microscopy recently attracted intensive attention capability acquiring images ultrahigh frame rate unfortunately achievable frame rate limited requirement overlap consecutive frames leads tradeoff frame rate pulse repetition rate amount temporal dispersion used optical image serialization paper demonstrate compressive sensing platform optical time stretch microscopy overcome tradeoff frame rate temporal dispersion time stretch achieve times higher frame rate conventional optical time stretch microscopy specifically computationally perform compressed optical time stretch microscopy experimental dataset acquired conventional optical time stretch microscopy demonstrate effects terms spatial resolution cell classification accuracy results indicate spatial resolution cell classification accuracy reach line scan rate mhz ghz respectively correspond five times times higher frame rates conventional optical time stretch microscopy achieve dispersion amount digitizer sampling rate
background hypoxia causes secondary headaches high altitude headache hah headache due acute mountain sickness secondary headaches mimic primary headaches migraine suggests common link review discuss possible role hypoxia migraine cluster headache methods narrative review investigates current level knowledge relation hypoxia migraine cluster headache based epidemiological experimental studies findings epidemiological studies suggest living high altitude areas increases risk migraine especially migraine aura human provocation models show hypoxia provokes migraine without aura whereas cluster headache reliably induced hypoxia possible pathophysiological mechanisms include hypoxia induced release nitric oxide calcitonin gene related peptide cortical spreading depression leakage blood brain barrier conclusion possible link hypoxia migraine maybe cluster headache exact mechanism currently unknown provocation models hypoxia yielded interesting results suggesting novel approach study depth mechanism underlying hypoxia primary headaches
although many successful applications neural networks nns however still drawbacks using neural networks nns control scheme study based model applied tension leg platform tlp system linear differential inclusion ldi state space representation constructed represent dynamics model control performance achieved using parallel distributed compensation pdc scheme ensure stability tlp systems subjected external wave force terms stability analysis linear matrix inequality lmi conditions derived using lyapunov theory guarantee robustness design stability tlp system simulation example based practical data given demonstrate feasibility proposed fuzzy control approach end discuss practical application field data wave properties structural characteristics results indicate efficiency robustness proposed based approach published elsevier
importance sustainable development energy efficiency efforts increased construction sector energy saving efforts buildings become important due global energy crisis energy rating systems developed globally assessment energy performance study international green building certificate energy performance certificate epc systems presented official epc system buildings turkey illustrated case studies energy consumption greenhouse gas emissions residential buildings calculated using official national software called bep impact lighting total energy performance residential buildings also examined changes energy performance values discussed various cases result study determined residential buildings constructed consume energy constructed lower energy performance class buildings use energy saving lamps also positive impact lighting total energy performance classes paper aims contribute promotion building energy certification systems energy efficiency issues construction sector
optimal use biomass global warming mitigation perspective depends upon numerous factors including competition land constraints goal study identifying optimal uses domestic biomass resources case denmark objectives minimizing global warming contribution fossil energy resource consumption purpose consequential life cycle assessment different options biomass performed optimal solutions identified given specific national environmental targets using linear programming results highlighted utilizing energy potential manure straw represents primary opportunity global warming mitigation purpose digestion manure combustion heat power production straw appear promising technologies utilization biomass biogas electricity heat generally preferred long coal oil still used within energy system yet fulfill environmental targets renewable energy transport sector diversion significant share biogas biofuels beneficial uses necessary completely phase coal oil additional biomass current domestic resources must included either domestic energy crops cultivation biomass biofuel import alternatively natural gas could used elsevier ltd rights reserved
theoretical study interfacial water waves free surface two layer system lower fluid taken heavier upper one lagrangian matching conditions introduced physical fields separated interface perturbation analysis carried third order find particle trajectory lagrangian description observing derived solution symbolic computation introduced obtaining fifth order solution lagrangian drifts wave frequency set also given part solutions discontinuities across interface found physical quantities generalized set effect found lagrangian mean levels come near free surface internal interface numerical calculations shown larger density difference relative wave height results larger drift velocity direction particle motion upper layer anti clockwise contrary lower layer better convergence lagrangian solution eulerian one numerically demonstrated barotropic mode wave motion dominated free surface elsevier ltd rights reserved
bracken fern invasive plant presents serious environmental ecological economic problems around world understanding spatial distribution bracken fern weeds therefore essential providing appropriate management strategies local regional scales aim study assess utility freely available medium resolution landsat oli sensor detection mapping bracken fern cathedral peak south africa achieve objective results obtained landsat oli compared derived using costly high spatial resolution worldview imagery since previous studies already successfully mapped bracken fern using high spatial resolution worldview image comparison done investigate magnitude difference accuracy two sensors relation acquisition costs evaluate performance landsat oli discriminating bracken fern compared worldview tested utility spectral bands derived vegetation indices well iii combinatidn spectral bands vegetation indices based discriminant analysis classification algorithm resampling training testing data reclassifying several times based combined data sets overall accuracies landsat worldview tested significant differences based mann whitney test results showed integration spectral bands derived vegetation indices yielded best overall classification accuracy landsat oli worldview respectively additionally use derived vegetation indices standalone data set produced weakest overall accuracy results landsat oli worldview images significant differences classification accuracies derived based landsat oli derived using worldview sensor although significant differences landsat worldview accuracies magnitude variation two sensors within acceptable range therefore findings study demonstrated recently launched landsat oli mtiltispectral sensor provides valuable information could aid long term continuous monitoring formulation effective bracken fern management acceptable accuracies comparable obtained high resolution worldview commercial sensor elsevier rights reserved
study deals mathematical modelling motion control pendulum driven spherical robot pdsr moving inclined plane firstly model pdsr inclined plane developed using lagrangian formulation afterwards pid controller tuned stabilise robot inclined plane heuristic fuzzy controller pid controller also designed move robot upward downward inclined plane approach target point switched control combination designed controllers finally suggested control motion robot inclined plane simulations conducted investigate compare performance proposed controllers experiments also conducted different cases validate simulations also evaluate control strategies via image processing
constipation common complaint slow transit constipation stc accounting significant proportion cases old age female gender psychiatric illness history sexual abuse associated stc exact cause stc remains elusive however multiple immune cellular changes demonstrated diagnosis requires evidence slowed colonic transit may achieved via numerous modalities variety medical therapies exist often met limited success minority patients ultimately require operative intervention evaluating patient stc important determine presence concomitant obstructed defecation forms enteric dysmotility may affect treatment decisions although variety surgical procedures reported subtotal colectomy ileorectal anastomosis commonly performed well studied procedure best track record success
sleep critical brain health age especially high risk newborn protecting challenge nicu many reasons babies almost always asleep difficult tell stage sleep many sources sleep disruption nicu entirely preventable sleep usually occurs part circadian rhythm ages high risk newborns exhibit circadian rhythmicity nicu environment conducive developing one structural operational strategies protect sleep beneficial effects brain outlined increased parental interaction baby may best way reduce noxious stimuli provide nurturing stimuli supporting sleep elsevier inc rights reserved
background age might affect change care needs patients hepatocellular carcinoma treatment transition process hospital home however studies focus objective aim study examine changes unmet supportive care needs young years old elderly years old groups patients hepatocellular carcinoma discharge months discharge methods longitudinal prospective study design used recruited participants teaching hospital taiwan data collected times within days discharge months discharge set questionnaires used assess participants levels supportive care needs symptom distress anxiety depression results total patients completed data collection process supportive care needs decreased monthly discharge health system information domain highest level unmet needs groups young group higher level overall unmet needs discharge lower level overall needs compared elderly group months discharge conclusions age could significant potential factor affect change unmet needs transition implications practice comprehensive assessment care needs especially health system information physical daily living domains discharge recommended design personalized education programs discharge
high energy demands poorly myelinated long axon hippocampal cortical neurons render neurons selectively vulnerable degeneration alzheimer disease however pathology engages major elements neurovascular unit mature alzheimer brain neurons glia blood vessels neurons present retrograde degeneration axodendritic tree capillaries stringvessels markedly reduced densities glia signs inflammatory activation neurons capillaries astrocytes mature alzheimer brain harbor structurally defective mitochondria clinically reduced glucose utilization decades cognitive deterioration betrays ongoing energy insufficiency beta hydroxybutyrate gamma hydroxybutyrate provide energy brain glucose utilization blocked early work mouse models alzheimer disease demonstrate ability reverse pathological changes alzheimer brain initial clinical trials reveal ability improve cognition every day function supplying brain energy holds great promise delaying onset alzheimer disease slowing progress elsevier ltd rights reserved
person perception research focused accuracy observers receiving truthful target information however real life people may often wish manage impression convey investigated whether people pose personality photographs sixty target participants posed photographs sought express high low poles big five traits means physical appearances observers rated targets personality likability photograph results showed targets successfully posed extravert lesser extent introvert neurotic non conscientious open targets could convey impressions high low agreeableness elsevier inc rights reserved
distribution potential electric field gradient square electric field simulated via finite element method dielectrophoresis dep assembly reduced graphene oxide sheets rgos graphene oxide sheets gos based electrical circuits fabricated via dep assembly mechanically exfoliated graphene sheets megs based electrical circuit also fabricated comparison electrical transport properties three types graphene based electrical circuits measured megs based electrical circuit possesses best electrical conductivity gos based electrical circuit poorest electrical conductivity among three circuits three types electrical circuits applied detection copper ions rgos based electrical circuit detect concentration low solution gos based electrical circuit detect chemical reduction possible mechanism electron transfer proposed detection facile fabrication method excellent performance imply rgos based electrical circuit great potential applied metal ion sensors
review considers history drug development primary headaches discusses challenges discovery innovative headache therapeutics advances headache genetics yet translate new classes therapeutics currently clear predictive human biomarkers primary headaches guide preventative drug discovery development primary headache disorder subtypes despite common phenotypic presentation undoubtedly heterogeneous pathophysiology judged variability response headache medicines sub classification headache subtypes homogenous specific phenotypes groups may facilitate genotyping provide sentinel patient groups used mechanism specific manner test new personalized treatment strategies headache medicine development triptan class serotonin htb receptor agonists advanced understanding neurobiology migraine pain subsequently resulted development calcitonin gene related peptide cgrp modulators showing promise acute preventative anti migraine agents despite successes many near misses failures discovery development headache therapeutics glutamate receptor antagonism whilst efficacious central side effects approaches nitric oxide synthase inhibition substance antagonism cortical spreading depression blockade despitehaving promising effects inbasic painmodels havenot delivered efficacy clinic future efforts may triage novel physiological mediators using human experimental models headache pain support drug discovery strategies target active pathways pharmacologically elsevier ltd rights reserved
one dimensional bimetallic nanowires introduced tio based matrix enhance photocatalysis efficiency expand light absorption range work recently metal nanowires attracted many attention photocatalyst research fields favorable electronic transmission properties especially aspect surface plasmon resonance effects moreover bimetallic nanowires nws shown better chemical stability ordinary monometallic nanowires recent works interestingly found sleeves bimetallic nanowires also modify schottky barrier interface tio metallic conductor beneficial separation photogenerated carriers tio network topology hence novel heterostructured photocatalyst composed nws tio nanoparticles nps fabricated one step hydrolysis approach explore photocatalytic performance tem edx mapping images tio nps nws tcn hybrid displayed nws wrapped compact tio layer retained one dimensional structure matrix experiments photocatalytic performance tcn nanocomposite significantly enhanced comparing pure tio acetaldehyde common gas pollutant environment employed evaluate photodegradation efficiency series tcn nanocomposites continuous feeding tcn exhibited excellent potodegradation performance dynamic photocatalytic efficiency tcn containing nws continuous ppm chcho feeding sccm visible light respectively esr results proved recombination photo generated electron hole pairs inhibited significantly tcn nanocomposite finally mechanism electron hole pairs separation transmission schottky barrier interface nws tio layers proposed based analyses elsevier rights reserved
employment cyclodextrin host guest complexation construct supramolecular assemblies emphasis polymer networks reviewed main driving force supramolecular assembly host guest complexation cyclodextrin hosts guest groups either may discrete molecular species substituents polymer backbone effects complexation properties molecular macroscopic levels discussed shown cyclodextrin complexation may used design functional polymer materials tailorable properties especially photo thermo redox responsiveness self healing
lesbian women engage hazardous drinking heterosexual women yet know relatively little explains disparity present study race socioeconomic status ses minority stress general psychological processes distress examined pathways hazardous drinking among young years black non hispanic white lesbian women used psychological mediation framework adaptation minority stress theory reserve capacity model theoretical underpinnings conceptual model current study self identified lesbian participants completed onetime online survey assessed race ses perceived sexual minority discrimination proximal minority stress concealment internalized homophobia lack connection lesbian community rumination social isolation psychological distress drinking cope hazardous drinking cross sectional results demonstrated black associated hazardous drinking via sequential mediators rumination psychological distress drinking cope ses associated hazardous drinking via sequential mediators sexual minority discrimination proximal minority stress rumination social isolation psychological distress drinking cope understanding pathways aid researchers clinicians studying working lesbians risk hazardous drinking
trust one challenging issues emerging cloud computing era past years numerous cloud service providers emerged providing similar kinds services become incredibly complex cloud clients make distinction among multiple cloud service providers offering similar kinds services cloud clients need trustworthy service providers provide services exactly per sla deviate promises though significant efforts form trust service providers clients providing data storage network security relatively fewer efforts made field trustworthiness determination monitoring compliance offered services per sla paper presents design trust evaluation framework uses compliance monitoring mechanism determine trustworthiness service providers compliance values computed processed using technique known improved technique order preference similarity ideal solution improved topsis obtain trust service providers case study based approach followed demonstrate usability applicability proposed framework experiments performed using real cloud data extracted cloud harmony reports experimental results clear proposed framework used real cloud environments determine trustworthiness service providers employing real time monitoring services
present study report full range physical diseases acquired survivors hodgkin lymphoma diagnosed adolescence young adulthood danish nationwide population based cohort study five year survivors hodgkin lymphoma diagnosed ages years comparison subjects matched survivors age year birth included hospital discharge diagnoses bed days obtained danish patient register specific disease categories gathered main diagnostic groups analysis conducted separately three subcohorts survivors survivors diagnosed information rehospitalisation hodgkin lymphoma survivors diagnosed split subcohort expected relapses subcohort rehospitalisation hodgkin lymphoma indicated relapse overall standardised hospitalisation rate ratios rrs confidence interval respectively corresponding rrs bed days highest rrs seen nonmalignant haematological conditions malignant neoplasms infections combined survivors hodgkin lymphoma adolescence young adulthood increased risk wide range diseases require hospitalisation risk depends calendar period treatment whether survivors rehospitalised hodgkin lymphoma thus likely relapse new excellent survival rates hodgkin lymphoma allowed increasing numbers patients enjoy normal disease free life expectancy nonetheless premature death remains concern owing risk late effects including second malignant neoplasms curative therapy authors present study quantified burden new diagnoses hodgkin lymphoma survivors showing among five year survivors diagnosed adolescence young adulthood significant proportion later suffered conditions requiring hospitalisation malignant neoplasms infections circulatory diseases accounted majority new diagnoses
paper reports suspended coil electromagnetic acoustic energy harvester aeh extracting acoustical energy developed aeh comprises helmholtz resonator wound coil bonded flexible membrane permanent magnet placed magnet holder harvester performance analyzed different sound pressure levels spls laboratory real environment laboratory connected omega load resistance subjected spl aeh generated peak load voltage resonant frequency working optimum load resistance aeh generated optimum load power real environment developed aeh produced maximum voltage exposed acoustic noise motorcycle generated optimum voltage placed surroundings domestic electrical generator
background texas department family protective services dfps created statewide network child abuse pediatricians working academic centers methods case data period reviewed child demographics risk factors physician determinations injury descriptors information made available physician results dfps cases referred period network utilization rates ranged counties served san antonio austin served counties cases outlying counties less likely involve older children african american children represented referrals caucasian asian children underrepresented prevalent risk factors included prior dfps history single parent household mental illness substance abuse domestic violence network providers found nonspecific evidence maltreatment cases determinations hindered poor quality photographs cases inadequate skeletal surveys insufficient information precluded case completion cases children years conclusions data indicate child abuse centers texas underutilized practice differences respect medical referrals across different regions findings concerning ethnic differences risk factors consistent national trends problems inadequate photographs case information may improve better training workers issue poor quality skeletal surveys requires study standard dfps criteria referrals child abuse pediatricians mitigate problems identified study elsevier ltd rights reserved
emergency contraception prevents pregnancy unprotected sex contraceptive failure use increased markedly countries product available counter yet barriers availability use remain although effective clinical trials yet possible show public health benefit terms reduction unintended pregnancy rates selective progesterone receptor modulators developed emergency contraceptives offer better effectiveness levonorgestrel still less effective use ongoing regular contraception methods inhibit ovulation whenever taken act ovulation prevent implantation strategies increase uptake effective ongoing contraception use would prevent pregnancies
loxapine first generation antipsychotic belonging dibenzoxazepine class recently loxapine reformulated lower dose producing inhaled powder directly administered lungs treat agitation associated psychiatric disorders schizophrenia bipolar disorder thus aim narrative clinical mini review evaluate efficacy tolerability inhaled loxapine treatment acute agitation patients psychiatric disorders efficacy inhaled loxapine evaluated one phase trial patients schizophrenia two phase iii trials patients schizophrenia bipolar disorder moreover two published case series patients borderline personality disorder dual diagnosis patients inhaled loxapine proven effective generally well tolerated administered agitated patients schizophrenia bipolar disorder two case series suggested inhaled loxapine may also useful treat agitation patients borderline personality disorder dual diagnosis studies needed clarify point however administration inhaled loxapine requires least kind patient collaboration recommended treatment severe agitation totally uncooperative patients moreover drug related risk bronchospasm must always kept mind planning use inhaled loxapine leading careful patient assessment prior administration also higher costs inhaled loxapine compared oral intramuscular medications taken account selecting treatment agitation
background familial combined hypolipidemia mendelian condition characterized substantial reductions major lipid fractions caused mutations inactivate gene angiopoietin like angptl whether angptl deficiency reduces risk coronary artery disease cad unknown objectives study goal leverage distinct lines evidence family included individuals complete compound heterozygote angptl deficiency population based study humans partial heterozygote angptl deficiency biomarker levels patients myocardial infarction test whether angptl deficiency associated lower risk cad methods assessed coronary atherosclerotic burden individuals complete angptl deficiency wild type first degree relatives using computed tomography angiography population angptl loss function lof mutations ascertained people cad control subjects lof mutations defined nonsense frameshift splice site variants along missense variants resulting wild type angptl activity mouse model biomarker study circulating angptl concentration measured people presented control subjects results individuals complete angptl deficiency showed evidence coronary atherosclerotic plaque angptl gene sequencing demonstrated approximately people heterozygous carrier lof mutation compared without mutation heterozygous carriers angptl lof mutations demonstrated reduction circulating triglycerides reduction low density lipoprotein cholesterol carrier status associated reduction odds cad odds ratio confidence interval individuals lowest tertile circulating angptl concentrations compared highest reduced odds adjusted odds ratio confidence interval conclusions angptl deficiency associated protection cad american college cardiology foundation
essential step wide scale dissemination investigate moderators intervention effectiveness study examined moderators effects universal school based mindfulness program adolescents depressive symptoms based theory previous research identified following potential moderators severity symptoms depression baseline gender age school track study uses pooled dataset two consecutive randomized controlled trials adolescents years secondary schools belgium results effectiveness based first trial published journal raes second consecutive trial conducted obtain equal distribution school tracks enlarge power yielding total students nine schools school parallel classes randomized mindfulness condition usual curriculum control condition data collected week week delivery training month follow moderation tested longitudinally multilevel models across three repeated measures across condition found moderation effects gender age school track six months training found marginally significant moderation effect severity symptoms depression baseline greater decrease symptoms students high levels depression general absence differential intervention effects gender age school track supports broad scope school based mindfulness group intervention
ankylosing spondylitis chronic inflammatory condition commonly affects axial skeleton common cardiac manifestation patients aortic root valve disease followed conduction rhythm abnormalities decreased coronary flow reserve myocardial infarction diastolic dysfunction however presence systolic dysfunction less described patients herein present two cases idiopathic dilated cardiomyopathy patients patients noted improvement ejection fraction following treatment clinical echocardiographic improvement anti inflammatory treatment might clue inflammatory nature myocardial problem investigations study issue required
background efforts aimed health care reform continued advances information technologies prompted interest among providers researchers patient web portals patient web portals password protected online websites offer patients hour access personal health information anywhere internet connection methods article based upon bibliographic searches pubmed reviews important developments web portals primary secondary disease prevention including patient web portals tethered electronic medical records disease specific portals health disparities health related community web portals results although findings uniformly positive several studies effectiveness health care system patient portals chronic disease management shown promising results regard patient outcomes patient web portals also shown promising results increasing adherence screening recommendations racial ethnic minorities younger persons patients less educated lower health literacy found less likely use patient portals conclusion additional studies needed utility effectiveness different elements web portals different patient populations include additional diseases health topics smoking cessation weight management
purpose reviewthis article aims examine relationships obsessive compulsive disorder ocd personality disturbance particular focus diagnostic aetiological treatment implications relationships recent findingspersonality disorders common ocd interact various ways accordance number proposed models relationship ocd obsessive compulsive personality disorder important conceptualised different ways may vary one person another clinically relevant implication presence schizotypal personality disorder ocd poor prognosis treatment outcome ocd findings effects personality disorders treatment outcome ocd inconsistent personality disorders largely due poor quality research better understanding specific relationships ocd personality disturbance lead tailored treatment approach summarylarge prospective studies needed better understand various relationships ocd specific personality disorders could conceptualised soundly studies also provide foundation effective treatments ocd patients occurring personality disorders
alternative approach conceptualizing measuring built environment developed forms basis new assessment tool role buildings reframed consider capabilities sustainability building provide inhabitants local community capability support sustainability defined ability improve local quality life human development index whilst remaining environmental carrying capacity environmental footprint approach clear implications role buildings enabling residents users achieve targets outcomes shifts focus net positive development toward configurations characteristics built environment appropriate particular context built environment sustainability tool best presented defines assesses configurations characteristics assessments conducted measuring extent required configurations characteristics exist capability built environment support sustainability best compared green building rating tool approaches order review methodology critically evaluate means improving built environment sustainability performance
paper demonstrates set pilot plant air blower heater systems connected modern industrial distributed control systems dcs used different control engineering laboratories undergraduate level student tasks include identification static dynamic process models tuning commissioning proportional integral derivative pid control loops well utilization commercial tools dcs engineering using pilot plants dcs scientific computing environment different courses lowers costs allows reutilization results enables efficient lab organization also supports process learning inner context different control engineering related subjects use industrial scale equipment commercial software helps students easily integrate later teams avoid reality shock making transition academia industry wiley periodicals inc
play proposed indicator positive emotions welfare higher vertebrates study investigated playfulness male rats exploring consistency across motivational states without prior short social isolation two age points early late adolescence twenty four male lister hooded rats housed cages four underwent two play tests conspecific play pairs tickling experimenter compared play home cage basal anxiety levels play pairs measures consistent across age motivational states independent anxiety positively valenced vocalizations tickling test also consistent across age yet negatively related anxiety play pairs tickling play contexts well social solitary play types unrelated therefore study supports existence consistent individual differences playfulness rats suggests different play contexts types represent motivationally distinct systems
paper investigate bogoyavlenskii kadomtsev petviashili equation used describe propagation nonlinear waves physics biology electrical networks find equation painleve integrable symbolic computation hirota bilinear forms solitary waves multi front waves derived elastic collisions among two three solitary waves graphically discussed waves maintain shapes amplitudes velocities collision phase shifts inelastic collisions among multi front waves discussed front waves coalesce one larger front wave collision region
present algorithm efficiently compute accurate volumes surface areas macromolecules graphical processing unit gpu devices using analytic model represents atomic volumes continuous gaussian densities volume molecule expressed means inclusion exclusion formula based summation overlap integrals among multiple atomic densities surface area molecule obtained differentiation molecular volume respect atomic radii many body nature model makes port gpu devices challenging knowledge first reported full implementation model gpu hardware accomplish used recursive strategies construct tree overlaps accumulate volumes gradients tree data structures minimize memory contention algorithm used formulation surface area based non polar implicit solvent model implemented open source plug named gaussvol popular openmm library molecular mechanics modeling gaussvol times faster best optimized implementation cpus achieving speeds excess day time step protein sized systems commodity gpus wiley periodicals inc
objective neural interactions cortex basal ganglia pivotal sensorimotor processing specifically coherency cortex subthalamic structures frequently studied phenomenon patients parkinson disease however unknown whether cortico subthalamic coherency might also relate cognitive aspects task performance language processing furthermore standard coherency studies challenged efficiently handle multi channel recordings methods eight patients parkinson disease treated deep brain stimulation simultaneous recordings surface electroencephalography deep local field potentials obtained bilateral subthalamic nuclei performing lexical decision task recent multivariate coherency measure maximized imaginary part coherency mic applied simultaneously accounting multi channel recordings results cortico subthalamic synchronization mic oscillations positively correlated accuracy lexical decisions across patients oscillations contrast multivariate mic significant correlation obtained extracting cortico subthalamic synchronization standard bivariate coherency conclusions cortico subthalamic synchronization may relate non motor aspects task performance reflected lexical accuracy significance results tentatively suggest relevance cortico subthalamic interactions lexical decisions multivariate coherency might effective extract neural synchronization multi channel recordings international federation clinical neurophysiology published elsevier ireland ltd rights reserved
recent years front national leadership marine pen experienced political revival elections membership numbers public opinion polls party made impressive gains argue article gains stem least part strategic repositioning party based populist discourse communication style content analysis posts press releases party facebook page first highlight besides giving front national presentable image marine pen changed front national two fronts rendered party discourse populist managed reframe party leitmotif immigration second quantitative analysis likes post find new discourse resonates well front national sympathizers
study examined role stress mediator relationship prior drug addiction current high risk sexual behaviour eight hundred twenty women aged years received care community based family planning clinics interviewed using composite international diagnostic interview sexual risk behavior assessment schedule also completed brief version self control scale measure problem solving strategies measures recent stressful events daily hassles ongoing chronic stress regardless addiction history stress exposure previous months associated risky sexual behaviour previous months structural equation modelling revealed month stress levels mediated relationship past drug addiction month high risk sexual behaviours well negative relationship problem solving strategies high risk sexual behaviours problem solving strategies moderate relationship drug addiction high risk sexual behaviours findings suggest stress management training may help reduce risky behaviour among young low income women copyright john wiley sons ltd
background purpose study investigate suitable first line approach best combination treatment primary mediastinal large cell lymphoma pmlbcl matter debate least two decades methods single centre experience treatment novo pmlbcl patients last years reviewed patients received macop chemotherapy thirty seven received rituximab mediastinal radiotherapy irradiated chemotherapy although receiving rituximab received rituximab without radiotherapy consolidation eleven patients received chemotherapy results sixty one patients achieved complete response macop without rituximab among partial responders obtained complete response radiotherapy end scheduled treatment patients complete partial response eleven patients relapsed within first years follow year overall survival patients died progression free disease free survival respectively statistically significant difference overall progression free survival noted among treatment groups although disease free survival difference documented conclusions data indicate third generation regimen like macop could considered suitable first line treatment mediastinal consolidation radiotherapy impacts survival complete response rates remains good strategy convert partial complete responses data suggest radiotherapy may avoided patients obtaining complete response immuno chemotherapy requires confirmation hoc studies
crucial step use dna markers biodiversity surveys assignment linnaean taxonomies species genus etc sequence reads allows use information known based taxonomic names taxonomic placement dna barcoding sequences inherently probabilistic dna sequences contain errors natural variation among sequences within species reference data bases incomplete false annotations however existing bioinformatics methods taxonomic placement either exclude uncertainty quantify using metrics probability paper evaluate performance recently proposed probabilistic taxonomic placement method protax applying annotated reference sequence data well unknown environmental data four case studies include contrasting taxonomic groups fungi bacteria mammals insects variation length quality barcoding sequences individually sanger sequenced sequences short illumina reads variation structures sizes taxonomies species variation completeness reference data bases representing known species results demonstrate protax yields essentially unbiased probabilities taxonomic placement means quantification species identification uncertainty reliable expected accuracy taxonomic placement increases increasing coverage taxonomic reference sequence data bases increasing ratio genetic variation among taxonomic levels within taxonomic levels conclude reliable species level identification environmental samples still challenging neglecting identification uncertainty lead spurious inference key aim future research completion taxonomic reference sequence data bases making two types data compatible
study aimed assess effects psychoeducational intervention designed improve direct care workers stress burnout job satisfaction person centered communicative behavior people dementia pretest posttest control group design conducted aged care facilities two experimental facilities received psychoeducational intervention control facilities received education data gathered care workers baseline immediately months intervention self administrated instruments video recorded morning care sessions experimental group showed significant decrease care workers burnout significant improvement several communicative behaviors involvement stress levels deteriorated months intervention effects found job satisfaction findings highlight importance providing care workers technical competences tools stress management might associated reduction levels exhaustion improved communicative behaviors
disseminated fungal infections due magnusiomyces capitatus rare occurring exclusively immunocompromised patients report first case liver transplant patient chronic rejection portal thrombosis capitatus fungemia refractory septic shock despite antibacterial antifungal treatment caspofungin empirical treatment patient died multiple organ failure subsequently mycological examinations blood cultures bronchoalveolar lavage fluid urine positive capitatus identified mass spectrometry confirmed sequencing respectively stain resistant caspofungin fluconazole best treatment appears combination amphotericin voriconazole amphotericin fluorocytosine elsevier masson sas rights reserved
background development angioedema rare yet serious clinical event may develop due adverse drug reaction rapid recognition treatment adverse reaction critical optimal patient outcomes however prevention occurrence preferred case report year old woman presented emergency department lingual angioedema caused addition everolimus medication regimen patient improved withdrawal offending agent standard treatment early recognition healthcare providers management everolimus induced angioedema vital successful patient outcomes report increases awareness everolimus potentially causative agent development angioedema
backgrounda high frequency hypogonadism reported male patients advanced cancer current study performed evaluate association low testosterone levels symptom burden survival male patients cancer methodsof consecutive male patients cancer endocrine evaluation total free bioavailable testosterone high sensitivity reactive protein crp vitamin thyroid stimulating hormone hydroxy vitamin cortisol levels presenting symptoms fatigue anorexia cachexia symptoms evaluated edmonton symptom assessment scale authors examined correlation using spearman test survival log rank test cox regression analysis resultsthe median age patients years majority patients white patients median level normal median normal median normal low values associated worse fatigue poor eastern cooperative oncology group performance status weight loss opioid use low associated increased anxiety decreased feeling well increased dyspnea whereas low found associated anorexia decreased values found significantly associated elevated crp low albumin hemoglobin multivariate analysis decreased survival associated low hazards ratio declining eastern cooperative oncology group performance status high crp decreased albumin conclusionsin male patients cancer low testosterone levels associated systemic inflammation weight loss increased symptom burden decreased survival high frequency hypogonadism reported male patients advanced cancer current study increased symptom burden systemic inflammation weight loss opioid use poor survival found associated decreased testosterone levels male patients cancer cancer american cancer society high frequency hypogonadism reported male patients advanced cancer current study increased symptom burden systemic inflammation weight loss opioid use poor survival found associated decreased testosterone levels male patients cancer
background objective study describe first based study use european position paper rhinosinusitis epos criteria study prevalence chronic rhinosinusitis crs general population sample methods crs symptom questionnaire mailed primary care patients geisinger clinic health system serving counties pennsylvania crs cases categorized four unique subgroups based epos symptoms obstruction discharge smell loss pain pressure smell loss without pain pressure facial pain pressure without smell loss smell loss pain pressure cases required nasal obstruction discharge logistic regression used evaluate potential factors associated crs subgroups results found patients met criteria crs prevalence peaked ages years dropped age odds crs higher among patients white younger smokers history medical assistance diseases crs subgroups modeled separately associations longer significant crs subgroups comorbid diseases strongly associated crs cases reported smell loss facial pain pressure weakest associations crs cases report symptoms conclusions crs highly prevalent heterogeneous condition differences risk factors health outcomes across symptom subgroups may indicative differences etiology implications disease management
background tracking changes neural dynamics based neuronal spiking activities critical step understand neurobiological basis learning behaving animals dynamical neurobiological processes associated learning also time varying makes modeling problem challenging new method developed novel multiwavelet based time varying generalized laguerre volterra tvglv modeling framework study time varying neural dynamical systems using natural spike train data projecting time varying parameters tvglv model onto finite sequence multiwavelet basis functions time varying identification problem converted time invariant linear parameters one effective forward orthogonal regression algorithm aided mutual information criterion applied selection significant model regressors terms refinement model structure generalized linear model fit approach finally employed parameter estimation spike train data results proposed multiwavelet based tvglv approach used identify synthetic input output spike trains spontaneous retinal spike train recordings proposed method gives excellent performance tracking either sharply slowly changing parameters high sensitivity accuracy regardless priori knowledge spike trains results indicate proposed method shown deal well spike train data comparison existing methods proposed multiwavelet based tvglv approach compared several state art parametric estimation methods like steepest descent point process filter sdppf chebyshev polynomial expansion method conventional sdppf algorithm sdppf splines wavelet expansion method shown poor performance tracking time varying system changes synthetic spike train data due slow convergence adaptive filter methods although chebyshev polynomial basis function method gave good parametric estimation results requires prior parameter estimation shown proposed multiwavelet based tvglv method track time varying parameter changes rapidly accurately conclusions multiwavelet based tvglv modeling framework developed paper provide computational modeling scheme investigating nonstationary properties track general forms changes time varying neural dynamics also may potentially applied investigate spatial temporal information underlying biomedical spiking signals elsevier rights reserved
paper online system identification method introduced lifetime diagnostic supercapacitors online strategy uses lyapunov based adaptation law estimate online supercapacitor parameters therefore adaptive observer stability guaranteed lyapunov direct method state health soh estimation crucial since aging introduces degradation supercapacitors performance might eventually lead failure soh usually measured offline time frequency domain characterization techniques spectroscopy however methods require interruption system operation hence suitable real time applications electric vehicles unlike online estimation strategies voltage current measurements required simulation experimental results along comparison two different methods highlight effectiveness proposed approach estimating soh
background late high throughput microarray sequencing data extensively used monitor biomarkers biological processes related many diseases circumstance support vector machine svm popularly used successful gene selection many applications despite surpassing benefits svms single data analysis using small mid size data inevitably runs problem low reproducibility statistical power address problem propose meta analytic support vector machine meta svm accommodate multiple omics data making possible detect consensus genes associated diseases across studies results experimental studies show meta svm superior existing meta analysis method detecting true signal genes real data applications diverse omics data breast cancer tcga mrna expression data lung disease idiopathic pulmonary fibrosis ipf applied result identified gene sets consistently associated diseases across studies particular ascertained gene set tcga omics data found significantly enriched abc transporters pathways well known critical breast cancer mechanism conclusion meta svm effectively achieves purpose meta analysis jointly leveraging multiple omics data facilitates identifying potential biomarkers elucidating disease process
demonstrate remote scene viewing system telepresence purposes system based pan tilt stereo camera captures stereo video transfers remote user network user end live stereo video processed displayed lead mounted display faster feedback achieved latency compensation using wider field view higher resolution camera appropriate subset image selected displayed introduce hardware configuration software framework system method calculate nomography camera image space user head image space perceived latency system estimated
carbon nanotubes cnts newly developed materials unique properties range industrial commercial applications rapid expansion production cnt materials may increase risk human exposure cnts studies rodents shown certain forms cnts potent fibrogenic inducers lungs cause interstitial bronchial pleural fibrosis characterized excessive deposition collagen fibers scarring involved tissues cellular molecular basis underlying fibrotic response cnt exposure remains poorly understood myofibroblasts major type effector cells organ fibrosis secrete copious amounts extracellular matrix proteins signaling molecules drive fibrosis myofibroblasts also mediate mechano regulation fibrotic matrix remodeling via contraction stress fibers recent studies reveal exposure cnts induces differentiation myofibroblasts fibroblasts vitro stimulates pulmonary accumulation activation myofibroblasts vivo moreover mechanistic analyses provide insights molecular underpinnings myofibroblast differentiation function induced cnts lungs view apparent fibrogenic activity cnts emerging role myofibroblasts development organ fibrosis discuss recent findings cnt induced lung fibrosis emphasis role myofibroblasts pathologic development lung fibrosis particular attention given formation activation myofibroblasts upon cnt exposure possible mechanisms cnts regulate function dynamics myofibroblasts lungs evident fundamental understanding myofibroblast function regulation lung fibrosis major influence future research pulmonary response nano exposure particle fiber induced pneumoconiosis human lung fibrosing diseases
insula anterior cingulate cortex core brain regions anchor salience network one several large scale intrinsic functional connectivity networks derived consistently using resting state functional magnetic resonance imaging fmri several studies shown insula anterior cingulate cortex play important roles interoceptive awareness study date examined association intrinsic salience network connectivity interoceptive awareness study sought test idea healthy young participants underwent resting state fmri scan heartbeat counting task outside scanner session greater salience network connectivity posterior insula anterior cingulate cortex using independent component analysis correlated higher accuracy heartbeat counting task furthermore using seed based approach greater interoceptive accuracy associated greater intrinsic connectivity insular functional subdivisions salience network regions including anterior insula orbitofrontal cortex ventral striatum midbrain associations remained correcting voxel wise grey matter volumes findings underscore critical role insular salience network intrinsic connectivity interoceptive awareness pave way future investigations salience network dysconnectivity affects interoceptive awareness brain disorders
ear prosthesis designed computer graphics software fabricated using printing process polyvinylidene fluoride pvdf use hearing aid addition prosthesis response pressure temperature observed pyroelectric piezoelectric properties ear prosthesis investigated using astable multivibrator circuit changes pvdf permittivity observed according variations pressure temperature results show prosthesis reliable use different conditions pressure temperature degrees degrees experimental results show almost linear inversely proportional behavior stimuli pressure temperature frequency response printed ear prosthesis promising tool great potentiality biomedical engineering field ability generate electrical potential proportional pressure temperature first time device processed additive manufacturing process printing work needs carried improve performance electrical stimulation nervous system thereby extending purpose prosthesis area sensory perception
background since treatment guidelines atopic dermatitis released korean atopic dermatitis association kada work group several advances management objective aimed establish updated evidence experience based treatment guidelines korean methods collected database references relevant systematic reviews guidelines regarding general management bathing skin care avoidance exacerbating factors education psychosocial support use moisturizers topical anti inflammatory antipruritic drugs evidence statement graded strength recommendation statement classified thirty nine kada council members participated three rounds voting establish expert consensus recommendations results basic treatment includes proper bathing skin care avoidance exacerbating factors proper education psychosocial support use moisturizers regular use moisturizer steroid sparing effect reduces relapse episodes short long term use topical corticosteroids calcineurin inhibitors improves symptoms encouraged use active proactive treatment wet wrap therapy used rapid recovery acute exacerbation topical anti pruritic drugs recommended treatment conclusion report provides date evidence experience based treatment guidelines regarding general management topical treatment addition average agreement scores obtained panel experts based korean healthcare system patient adherence presented
long history research acetylcholine ach function myelinating glia resurgence interest recently result therapeutic potential manipulating ach signaling promote remyelination broader interest neurotransmitter signaling activity dependent myelination myelinating glia express major types muscarinic nicotinic ach receptors different stages development acetylcholinesterase butyrylcholinesterase highly expressed white matter review traces history research ach signaling schwann cells oligodendrocytes myelin sheath summarizes current knowledge intracellular signaling functional consequences ach signaling myelinating glia implications ach diseases alzheimer disease multiple sclerosis white matter toxicity caused pesticides considered together outline major questions future research
purpose study designed investigate whether serum concentrations leptin resistin adiponectin obese normal weight patients primary knee osteoarthritis correlate clinical radiological stages disease percentage total body fat methods seventy three patients knee divided obese normal weight groups clinically evaluated according knee society score kss radiologically assessed using kellgren lawrence scale percentage total body fat anthropometric data also given serum leptin resistin adiponectin concentrations measured elisa correlated clinical radiological anthropometric parameters results leptin concentrations significantly higher obese patients positively correlated radiologically assessed grade normal weight group resistin adiponectin concentrations identical obese normal weight patients negatively correlated clinical status obese patients groups percentage total body fat positively correlated obese normal weight respectively radiologically assessed grade however correlations found clinical status patients conclusions found obese patients knee increased percentage total body fat elevated serum leptin concentration might favour advancement clinical radiologically assessed changes joint structures normal weight patients correlates radiologically assessed changes affect appreciable extent clinical status patients
background unintended pregnancy among adolescents represents important public health challenge high income countries well middle low income countries numerous prevention strategies health education skills building improving accessibility contraceptives employed countries across world effort address problem however uncertainty regarding effects interventions hence need review evidence base objectives assess effects primary prevention interventions school based community home based clinic based faith based unintended pregnancies among adolescents search methods searched relevant studies regardless language publication status november searched cochrane fertility regulation group specialised trial register cochrane central register controlled trials central cochrane library issue medline embase lilacs social science citation index science citation index dissertations abstracts online gray literature network healthstar psycinfo cinahl popline reference lists articles selection criteria included individual cluster randomised controlled trials rcts evaluating interventions aimed increase knowledge attitudes relating risk unintended pregnancies promote delay initiation sexual intercourse encourage consistent use birth control methods reduce unintended pregnancies adolescents aged years years data collection analysis two authors independently assessed trial eligibility risk bias extracted data appropriate binary outcomes pooled using random effects model confidence interval appropriate combined data meta analyses assessed quality evidence using grade approach main results included rcts enrolled adolescents participants ethnically diverse eighteen studies randomised individuals randomised clusters schools classrooms communities neighbourhoods three studies mixed individually cluster randomised length follow varied three months seven years months common duration four trials conducted low middle income countries others conducted high income countries multiple interventions results showed multiple interventions combination educational contraceptive promoting interventions lowered risk unintended pregnancy among adolescents significantly individual rcts participants moderate quality evidence however reduction statistically significant cluster rcts evidence possible effects interventions secondary outcomes initiation sexual intercourse use birth control methods abortion childbirth sexually transmitted diseases conclusive methodological strengths included relatively large sample size statistical control baseline differences limitations included lack biological outcomes possible self report bias analysis neglecting clustered randomisation use different statistical tests reporting outcomes educational interventions educational interventions unlikely significantly delay initiation sexual intercourse among adolescents compared controls studies participants low quality evidence educational interventions significantly increased reported condom use last sex adolescents compared controls receive intervention studies participants moderate quality evidence however clear educational interventions effect unintended pregnancy reported included studies contraceptive promoting interventions adolescents received contraceptive promoting interventions little difference risk unintended first pregnancy compared controls studies participants moderate quality evidence use hormonal contraceptives significantly higher adolescents intervention group compared control group studies participants high quality evidence
background since conception mid international participation extreme sports grown rapidly recent death extreme snowmobiler caleb moore winter games demonstrated serious risks associated sports purpose examine incidence prevalence head neck injuries hnis extreme sports study design descriptive epidemiological study methods national electronic injury surveillance system neiss used acquire data sports included winter summer games data neiss database collected individual sport per year type hni cumulative data overall incidence injuries entire year period calculated national estimates determined using neiss weighted calculations incidence rates calculated extreme sports using data outdoor foundation participation reports results million injuries reported hnis hnis head injuries neck injuries sports highest total incidence hni skateboarding snowboarding skiing motocross severe hni cervical skull fracture accounted extreme sports hnis skateboarding highest percentage severe hnis conclusion number serious injuries suffered extreme sports increased participation sports continues grow greater awareness dangers associated sports offers opportunity sports medicine orthopaedic physicians advocate safer equipment improved site medical care research regarding extreme sports injuries
cervical cancer one common types cancer among women worldwide order identify micrornas mirnas mirs mrnas associated carcinogenesis cervical cancer investigate molecular mechanisms cervical cancer mirna microarray gse mrna microarrays gse gse gse cervical cancer retrieved gene expression omnibus datasets analyzed order obtain differentially expressed genes degs mirnas using geor tool gene ontology pathway enrichment analysis degs performed using database annotation visualization integrated discovery protein protein interaction ppi analysis degs conducted using search tool retrieval interacting genes software visualized using cytoscape followed hub gene identification biological process pathway enrichment analysis module selected ppi network using molecular complex detection plugin addition mirecords applied predict targets differentially expressed mirnas total degs differentially expressed mirnas identified degs mainly enriched terms associated cell cycle ppi network cyclin dependent kinase topoisomerase dna alpha aurora kinase aurka minichromosome maintenance complex component mcm higher degrees connectivity significant module detected ppi network aurka mcm kinesin family member exhibited higher degrees module genes module mainly involved cell cycle dna replication pathway addition estrogen receptor predicted potential target mirnas total degs identified potential targets mir conclusion results indicated microarray dataset analysis may provide useful method identification key genes patterns successfully identify determinants carcinogenesis cervical cancer functional studies candidate genes mirnas databases may lead increased understanding development cervical cancer
wearable healthcare devices monitoring treating protecting applications provide reliable newfangled interactive service people herein functional smart face mask based electrospun polyetherimide pei electret nonwoven developed virtue surplus charges maintained steadily pei nonwoven smart face mask possesses functions removing particulate matter generating electricity moreover unique applications dynamically monitoring particulate matter removal ability human respiratory rates demonstrated besides offering unique air filter study promisingly promote progress self powered wearable electronics
health care researchers recently developed several home based sleep monitoring systems mobile applications support healthy sleep monitoring user sleep environment activities sleep quality study describes design evaluation electrooculogram eog based system automatic sleep monitoring compared polysomnogram electroencephalogram recordings eog advantage easy placement operated users also design intelligent eye mask user friendly measuring sleep stage quality two user experiments carried demonstrate proposed system produces valid measurements sleep stage sleep quality good usability reliability disturbing sleep significantly findings suggest system also applied long term sleep monitoring sleep environment control improve user sleep quality make sleep comfortable
order efficiently obtain frequencies solution multigrid solver used solve navier stokes equations incompressible flows method uses cell cell gauss seidel smoother straightforwardly parallelizable moreover coarsest grids coarse solved parallel proposed method splits cartesian computational domain well balanced sub domains respect two dimensions efficient parallel procedures using mpi libraries permit get high strong weak scalability whole parallel software comparison done mpi hybrid mpi openmp parallelism elsevier rights reserved
objective childhood asthma major public health problem development multifactorial examined whether neighborhood cohesion disorder associated caregiver report asthma age years methods study secondary data analysis united states national survey children health data available children age years old born term preterm birthweight neighborhood disorder cohesion assessed based caregivers responses validated questionnaires child asthma diagnosis reported caregiver multivariable logistic regression used examine relationship neighborhood factors caregiver report child asthma accounting individual level covariates results approximately two thirds children white lived households income federal poverty line asthma present children child female sex associated reduced risk caregiver reported asthma non hispanic black race smokers household independently associated increased risk multivariable models models neighborhood disorder significantly associated asthma adjusted odds ratio aor confidence interval neighborhood cohesion aor conclusion even adjustment several individual level factors neighborhood disorder associated caregiver report asthma nationally representative sample year old children research needed better understand risk factors different levels socio ecological framework may interact affect childhood asthma development
numerically solve functional differential equations fdes particle electrodynamics using full electrodynamic force obtained retarded lienard wiechert potentials lorentz force law contrast usual formulation uses coulomb force scalar potential reducing electrodynamic body problem system ordinary differential equations odes ode formulation mathematically suspect since fdes odes known incompatible however coulomb approximation full electrodynamic force believed adequate physics test long standing belief comparing fde solution ode solution historically interesting case classical hydrogen atom solutions differ key qualitative difference full force involves delay torque existing code inadequate calculate detailed interaction delay torque radiative damping however symbolic calculation provides conditions delay torque approximately balances order radiative damping thus investigations required prematurely concluded radiative damping makes classical hydrogen atom unstable solutions fdes naturally exhibit infinite spectrum discrete frequencies conclusion coulomb force valid approximation full electrodynamic force body interaction needs reformulated various current contexts molecular dynamics
full field laser doppler perfusion imaging offers advantages scanning laser doppler imaging effects movement artifacts reduced increased frame rate allows rapid changes blood flow imaged custom made cmos sensor offers several advantages commercial cameras design optimized detected signals example laser doppler signals known bandwidth similar khz low modulation depth therefore design amplify component sampling rate anti aliasing filter appropriate signal bandwidth would beneficial additional advantage custom made sensors chip processing blood flow allows data bottleneck exists photo detector array processing electronics overcome processed data read image sensor display low data rate fully integrated pixel array imaging blood flow presented chip analog signal processing used amplify component normalize signal light intensity provide anti aliasing chip digital signal processing used implement filters required calculate blood flow imaging array incorporated device used clinical setting results presented demonstrating changes blood flow occlusion release tests
three previous studies manipulations orthographic neighborhood size orienting task used differentiate item specific relational processing young adults aged standard recognition tasks current study attempts investigate memory deficits older adults aged using similar manipulations experiment manipulated orthographic neighborhood size within item recognition task young adults demonstrated standard mirror effect showing accurate performance low words effect found older adults possibly indicating deficit item specific processing experiment included orienting task study emphasize specific type processing younger adults performance influenced orienting task older adults showed consistently better performance high words results suggest older adults show deficit item specific processing relying relational processing regardless task
mitochondria harbor oxidative phosphorylation oxphos system aerobic conditions produces bulk cellular adenosine triphosphate atp mitochondrial genome encodes key components oxphos system transcribed mitochondrial rna polymerase polrmt levels mitochondrial transcription correlate respiratory activity cell therefore compounds increase decrease mitochondrial gene transcription may useful fine tuning metabolism could used treat metabolic diseases certain forms cancer report establishment novel high throughput assay technology allowed screen library diverse compounds effects mitochondrial transcription vitro following secondary screens facilitated assay principle identified compounds efficiently selectively inhibit mitochondrial transcription active also cell culture method easily adaptable rna dna polymerases varying spectroscopic detection technologies
cardiosphere derived cell cdc infusion damaged myocardium shown reparative effect could improved better selection patients cell subtype cdcs isolated patients ischemic heart disease able support vessel formation vitro ability varies patients primary aim study investigate whether vascular supportive function cdcs impacts therapeutic potential goal improving patient stratification subgroup patients produced cdcs efficiently support vessel formation poor supporter cdcs reduced levels proliferation increased senescence despite isolated manner similar immunophenotype cdcs able support vessel formation rodent model myocardial infarction poor supporter cdcs limited reparative effect compared cdcs efficiently supported vessel formation vitro work suggests patients provide cells suitable cell therapy assessing vascular supportive function cells could used stratify patients truly benefit cell therapy would better suited allogeneic transplant regenerative preconditioning cells precision medicine fashion could reduce costs culture times improve clinical outcomes patient prognosis
body condition important determinant fitness many natural populations however many fitness traits underlying genes regulate body condition remain elusive dopamine receptor gene drd promising candidate dopamine known play important role regulation food intake metabolism glucose lipids vertebrates study take advantage large data set greater flamingos phoenicopterus roseus test whether drd polymorphism predicts early body condition ebc controlling whole genome effects inbreeding outbreeding using microsatellite multilocus heterozygosity mlh typed individuals exon homologue human drd gene microsatellite markers controlling effects yearly environmental variations differences sexes found strong evidence association exon drd polymorphisms ebc variation explained drd polymorphism whereas weak evidence mlh predicts ebc ebc likely polygenic trait considerable amount variation explained single gene knowledge first study show association exon drd polymorphism body condition non human animals anticipate drd gene well genes coding neurotransmitters receptors may play important role explaining variation traits affect fitness
background objective describe patterns mechanisms water tubing related injuries treated emergency departments methods national electronic injury surveillance system used examine cases water tubing related injuries sample weights used calculate national estimates water tubing related injuries analyses conducted results estimated injuries treated emergency departments water tubing related injuries annual number cases increased year study period sprains strains accounted largest portion injuries head frequently injured body part children adolescents years likely individuals years sustain sprains strains commonly injured impact water conclusions patterns water tubing related injuries differ children adults research needed determine best reduce injuries
multidisciplinary versatile characteristics biosensors make attractive topics introduce science engineering concepts secondary education classroom techniques used biosensors easy demonstrate intriguing students evaluated application areas techniques intriguing students survey developed min introductory lesson plan hands experience survey conducted determine students greatest interests motivations among four biosensor applications medical diagnostics food safety biosecurity environmental monitoring well seven techniques used biosensors genetic engineering nanotechnology circuit building microfabrication printing smartphone utilization computer programming application middle school students showed interest food safety followed environmental monitoring medical diagnostics high school students showed interest medical diagnostics techniques used biosensors middle school students showed interest printing followed circuit building smartphone utilization high school students showed interest genetic engineering nanotechnology capture interest early students education designed min lesson plan middle school students using application areas food safety environmental monitoring well techniques printing circuit building smartphone utilization simplified sampling protocols introduced monitoring coli lettuce salmonella chicken packaging influenza aerosols example biosensor commercial glucose assay kit demonstrated using simple photometric circuit including led photodiode optical transducer second example commercial pregnancy test strip demonstrated using smartphone camera optical transducer finally plastic attachment smartphone made printer demonstrated improve sensitivity reproducibility pregnancy test lesson carried classroom results exemplify potential benefit using biosensor research middle school classroom well possibility inspiring students toward science engineering fields study careers
objective determine whether psychopathic traits assessed mid adolescence predicted mental health psychosocial antisocial including criminal outcomes years later would thereby provide advantages diagnosing conduct disorder method eighty six women men assessed mid adolescence first contacted clinic substance misuse reassessed years later assessments adolescence include psychopathy checklist youth version pcl depending age either kiddie schedule affective disorders schizophrenia school aged children structured clinical interview diagnostic statistical manual mental disorders fourth edition scid assessments early adulthood included scid self reports psychosocial functioning aggressive behaviour criminality official criminal records results antisocial facet score positively predicted number anxiety symptoms likelihood receiving treatment substance use disorders suds lifestyle antisocial facet scores negatively predicted global assessment functioning scores contrast interpersonal score male sex independently positively predicted number months worked studied interaction lifestyle sex indicating among men women increase lifestyle facet score associated less time worked studied interpersonal antisocial scores positively predicted school drop antisocial facet scores predicted number symptoms antisocial personality disorder alcohol suds violent nonviolent criminality much strongly among males females predictions numbers symptoms similar conclusions psychopathic traits among adolescents misuse substances predict array outcomes subsequent years information levels traits may useful planning treatment
material forming industry urgently needs high quality engineering technical skill talents practical operation ability using kinds digital tools independent die mould design manufacture paper analyzes material forming industry situation development trend current situation shanghai mould talents demand training results showed people possessing one post fusing multidisciplinary knowledge mastering multi capacity realizing future development demand exceeds supply provide support breakthrough cultivationin professional positioning talent cultivation aim determining
teeth brittle highly susceptible cracking propose observations cracking used diagnostic tool predicting bite force inferring tooth function living fossil mammals laboratory tests model tooth structures extracted human teeth simulated biting identify principal fracture modes enamel examination museum specimens reveals presence similar fractures wide range vertebrates suggesting cracks extended ingestion mastication use fracture mechanics materials engineering provides elegant relations quantifying critical bite forces terms characteristic tooth size enamel thickness role enamel microstructure determining cracks initiate propagate within enamel beyond discussed picture emerges teeth damage tolerant structures full internal weaknesses defects yet able contain expansion seemingly precarious cracks fissures within enamel shell findings impact dietary pressures forms undercurrent study
objective satiety perception satisfied fullness represents summation neural hormonal influences satiety assessed drink tests including water load objective study confirm difference water load volume nonobese control children children functional dyspepsia children irritable bowel syndrome ibs obese children methods total children ages years participated study children ibs obese children nonobese age matched control children subjects drank much water possible minutes stomachs felt full results children ibs groups drank less water nonobese controls obese children drank water nonobese controls water load test demonstrated high specificity poor sensitivity predicting children conclusions water load test offers simple noninvasive research tool measure satiety children chronic abdominal pain drank less nonobese control children however water load test discriminate ibs obese children drank water groups suggesting possibility underlying abnormality perception satiety
introduction study designed evaluate efficacy safety treating irritable bowel syndrome patients proper dose moxibustion methods analysis study week long randomised controlled pilot clinical trial twentyfour patients recruited randomly allocated groups moxibustion treatment intervention group moxibustion treatment control group groups receive two moxibustion sessions week weeks sessions total primary outcome measured using bowel symptom severity scale inclusion criteria follows patients years old either gender patients experienced repeated abdominal pain discomfort uncomfortable sensation described pain least times per month association two following previous months improvement defecation onset associated change frequency defecation onset associated change form appearance stool included patients provided written consent clinical ethics committee agreed clinical trial plan follow observations ethics dissemination research protocol reviewed approved institutional review board trial centre semyung korean medicine hospital irb results published journal disseminated electronically print elsevier gmbh rights reserved
pins sub assemblies cone drilling bits used dislodge rock pin head may different shapes chisel hemisphere etc according intended nature rock pin body cylindrical shape serves hold embed body rolls pins made sintered carbide combines best contradictory properties hardness toughness sintered metal carbides break suffering small plastic strain classified brittle materials following authors present results studies conducted conditions partially reproduce actual conditions lack drilling fluid however acutes test conditions cutting structures cone drill bits making clear subsets tensions working base drilling hole exceed strength materials made
study orthopedic surgeons rural regional southeast australia determine attitudes investigation management osteoporosis found believe follow regard osteoporosis mtf important responsibility follow diagnosis management lies primary health care current communication systems poor purpose introduction investigation treatment osteoporosis minimal trauma fracture mtf regarded sub optimal strong evidence benefit identifying treating osteoporosis mtf discussion possible role orthopedic surgeons might play management osteoporosis mtf study surveyed orthopedic surgeons rural regional southeast australia determine attitudes investigation management osteoporosis role health professionals play communication coordination follow care methods survey developed piloted prior posted orthopedic surgeons asking opinions general management osteoporosis roles responsibilities health professionals dealing osteoporosis following mtf results responses received participants majority respondents agreeing important treat osteoporosis following mtf less respondents felt responsibility initiate discussion treatment investigation mtf respondent felt coordination osteoporosis care good stated poor communication discharge mostly left hospital stated follow study shows many rural orthopedic surgeons believe follow regard osteoporosis mtf important responsibility follow diagnosis management osteoporosis lies primary health care current communication systems poor
objective among selective serotonin reuptake inhibitors ssris paroxetine strongly anticholinergic might lead higher risk adverse outcomes mortality study examined risk mortality depressed elderly nursing home patients using paroxetine ssris methods study used minimum data set linked medicare data propensity score matched retrospective cohort study design achieve study objective new users paroxetine ssris followed reached end follow period year switched different antidepressant class used psychotherapy gap days use index antidepressant class whichever occurred earlier robust cox proportional hazard model used evaluate risk mortality associated use paroxetine ssris depressed elderly nursing home residents results matching yielded patients two treatment groups unadjusted incidence mortality paroxetine ssris users matched cohort robust cox model find significant difference risk mortality two groups hazard ratio confidence interval conclusions study find significant difference risk mortality users paroxetine ssris among elderly nursing home patients depression need evaluation adverse effects paroxetine due anticholinergic effects geriatric population
since inception concept secondary psychopathy contrasted primary psychopathy grounds neuroticism affect instability anxiety nonetheless etiology primary psychopathy various possible expressions received ample attention secondary psychopathy largely neglected discussed cluster analytic studies paper seeks fill caveat delineating continuum secondary psychopathic individuals may set apart exploring potential sources within group homogeneity heterogeneity secondary psychopathic individuals share number etiological antecedents attachment problems childhood maltreatment neurobiological dysfunctions vary different temperamental predispositions specific types maltreatment experienced childhood neglect abuse trauma abuse low high prefrontal catecholaminergic activity thus creating heterogeneity observed group secondary psychopathic individuals may situated continuum spans attentional hyposensitivity cognitive distractibility far left side associated deficient prefrontal catecholamine activity childhood neglect abuse ultimately culminating detached expressions secondary psychopathy callousness hedonism low worrying attentional hypersensitivity cognitive rigidity far right side associated non optimally high levels catecholamine activity childhood relational trauma abuse leading unstable expressions secondary psychopathy hostility neuroticism instability worrying elsevier ltd rights reserved
network computer systems administrators facing serious problem big network traffic data analysis became difficult work administrators extract analysis abnormal normal patterns large amounts network traffic data currently traditional relational database management systems rdbms unsuitable store large amount data designed storing processing structured data hive data warehouse tool built top hadoop storing processing querying analysis large amount data hive stores data table similar relational database management system paper propose hadoop based traffic querying analyzing system handles tcp icmp udp analysis big network traffic data system consists six modules data collection module transferring storing information module convertor module data mining process module dmsc module report module also performed complex search queries compared query response times mysql hive hadoop environment result scenario mysql outperform cluster four hive nodes querying icmp protocol information nevertheless mysql database stored network traffic data million records query tcp protocol information moreover observed average query response times hive hadoop cluster reduce continuously scale node cluster
article report electrochemical synthesis simultaneous situ coating magnetic iron oxide nanoparticles mnps polyvinylpyrrolidone pvp polyethylenimine pei cathodic deposition carried electro generation surface cathode aqueous solution fecl used deposition bath electrochemical precipitation experiments performed direct current mode current density min polymer coating performed identical deposition bath containing pvp pei deposited uncoated pvp pei coated mnps characterized powder ray diffraction xrd fourier transform infrared spectroscopy ftir thermogravimetric analysis tga dynamic light scattering dls vibrating sample magnetometer vsm field emission scanning transmission electron microscopies sem tem structural xrd analyses revealed samples composed pure crystalline magnetite feo morphological observations sem tem proved product spherical nanoparticles range presence two coating polymers pvp pei surface electro synthesized mnps proved ftir dls results percentage polymer coating mnps surface also determined based dsc tga data high magnetization value coercivity remanence values measured vsm indicated superparamagnetic nature prepared mnps obtained results confirmed prepared feo nanoparticles suitable physico chemical magnetic properties biomedical applications elsevier rights reserved
plasma patients types hereditary angioedema unstable incubated plastic inert vessel degrees manifested progressively increasing formation bradykinin also persistent low level patients even symptomatic phenomena due properties subcomponent factor xii bimolecular complex prekallikrein high molecular weight kininogen purified auto activates physiologic buffers activates turn depletes occurs inhibitor deficient complex prekallikrein acquires inducible active site present prekallikrein tris type buffers cleaves stoichiometrically release bradykinin phosphate buffer auto activates generate kallikrein bradykinin thus immunologic depletion inhibitor factor xii deficient plasma phosphate natural buffer auto activates incubation release bradykinin normal inhibitor prevents occurring attacks angioedema factor xii auto activates surfaces initial factor xiia formed converts prekallikrein kallikrein kallikrein cleaves release bradykinin kallikrein also rapidly activates remaining factor xii factor xiia additional cleavages convert factor xiia factor xiif factor xiif activates enzymatically levels approach zero depleted also possibility kallikrein generated first result activation prekallikrein complex heat shock protein released endothelial cells followed kallikrein activation factor xii
role radial endobronchial ultrasound ebus assisted transbronchial biopsy tbb diagnosis peripheral pulmonary lesions well established however study addressed safety value hemato oncological patients presenting non resolving infiltrates persistent febrile neutropenia assess safety feasibility ebus assisted tbb severe thrombocytopenic neutropenic patients period months eight patients assessed ebus assisted tbb adequate platelet transfusion technique allowed precise localisation sampling pulmonary lesions seven eight patients seven patients ebus assisted tbb enabled treatment optimization invasive fungal infection diagnosed four patients idiopathic acute fibrinous organising pneumonia three patients granulomatous inflammation undetermined origin one patient importantly complications bleeding observed ebus assisted tbb promising safe procedure evaluation nonresolving pulmonary infiltrates febrile neutropenic hemato oncological patients
article first time presents generation roots rotor tooth profiles based assur group associated virtual linkage method taking original roots rotor example structure geometry roots rotor introduced based principle inversion equivalent virtual linkage identified generating dedendum tooth profile rotor using linkage decomposition associated elemental assur groups algorithm computing tooth curve constructed leading explicit expression rotor profile corresponding numerical simulation verifying validity proposed approach demonstration purpose virtual linkage method extended generation tooth profiles variants roots rotors arc cycloidal curves arc involute curves integrated computer aided design computer aided engineering computer aided manufacturing software platforms well three dimensional printing technology article provides efficient intuitive approach roots rotor system design analysis development
control scheme proposed islanded lowinertia three phase inverter based microgrid high penetration photovoltaic generation resources output inverter programmed emulate dynamics nonlinear oscillator virtual oscillators within controller implicitly coupled physical electrical network asymptotic synchronization oscillators guaranteed design result stable power system emerges innately communication inverters time domain switching level simulation results microgrid penetration demonstrate merits proposed technique particular show load voltage maintained prescribed bounds spite variations incident irradiance step changes load
use proteomics bioinformatics substantially contributes improved understanding proteomes novel depth knowledge comes cost increased computational complexity parallelization across multiple computers strategy termed distributed computing used handle increased complexity however setting maintaining distributed computing infrastructure requires resources skills readily available research groups propose free open source framework named pladipus greatly facilitates establishment distributed computing networks proteomics bioinformatics tools pladipus straightforward install operate thanks user friendly graphical interface allowing complex bioinformatics tasks run easily network instead single computer result researcher benefit increased computational efficiency provided distributed computing hence empowering tackle complex bioinformatics challenges notably enables research group perform large scale reprocessing publicly available proteomics data thus supporting scientific community mining data novel discoveries
background previous reports regarding cause evolution liver injury patients anorexia nervosa refeeding process management remains controversial study aimed determine risk factors elevated liver enzymes refeeding effect therapeutic process severely malnourished patients eating disorders methods retrospective cohort study female inpatients single hospital january march normal alanine aminotransferase alt levels admission divided two groups according presence absence elevated alt levels refeeding compared results median age body mass index bmi patients admission interquartile range iqr years iqr respectively compared cohorts significantly patients early onset age group years old elevated alt levels refeeding patients longer median time nadir bmi days addition onset age odds ratio confidence interval time nadir bmi significantly associated odds elevated alt levels refeeding conclusions results study suggest early age onset may potential risk factor elevated alt levels refeeding severely malnourished patients eating disorders furthermore elevated alt levels refeeding significantly associated delay start weight gain significant relationship found amount initial prescribed calories elevated alt levels refeeding median time maximum alt iqr days refeeding process started
accumulating evidence bumetanide used decades potent loop diuretic also exerts effects brain disorders including autism neonatal seizures epilepsy related effects kidney rather mediated inhibition neuronal cotransporter isoform nkcc however following systemic administration brain levels bumetanide typically needed inhibit nkcc critically limits clinical use treating brain disorders recently active efflux transport blood brain barrier bbb suggested process involved low brain plasma ratio bumetanide presently clear transporters involved understanding processes explaining poor brain penetration bumetanide needed developing strategies improve brain delivery drug present study administered probenecid selective inhibitors active transport carriers bbb directly brain mice minimize contribution peripheral effects brain penetration bumetanide furthermore vitro experiments mouse organic anion transporter oat overexpressing chinese hamster ovary cells performed study interaction bumetanide bumetanide derivatives several known inhibitors oats oat mediated transport vivo experiments demonstrated uptake efflux bumetanide bbb much complex previously thought seems restricted passive diffusion active efflux transport mediated oat also organic anion transporting polypeptide oatp oatpla multidrug resistance protein explain extremely low brain concentrations achieved systemic administration bumetanide limiting use drug targeting abnormal expression neuronal nkcc brain diseases elsevier ltd rights reserved
purpose purpose paper investigate newtonian heating slip effect mixed convective flow near stagnation point porous medium thermal radiation presence magnetohydrodynamic mhd heat generation absorption chemical reaction design methodology approach governing nonlinear coupled equations converted ordinary differential equations similarity transformation equations solved numerically using runge kutta fehlberg method shooting technique analytically using homotopy analysis method ham findings effects different parameters fluid flow heat transfer investigated found velocity temperature profiles increase increase biot number velocity concentration profiles increase decreasing chemical reaction parameter practical implications paper helpful engineers scientists field thermal manufacturing engineering originality value two dimensional boundary layer flow vertical plate slip convective boundary conditions near stagnation point analysed presence magnetic field radiation heat generation absorption paper helpful engineers scientists field thermal manufacturing engineering
paper proposes optimization model determine optimal tank size single residential housing unit rainwater harvesting storage taking account site specific data rainfall profile roof area building water consumption per capita number residents integrated optimization model based linear programming proposed decide size rainwater storage tank build net present value total tank construction costs freshwater purchase costs minimized proposed model tested case study northern cyprus results emphasized feasibility rainwater harvesting sustainable supplement depleting aquifers region study also offers managerial insights impact various parameters number residents roof area discount rate water consumption per capita unit cost building rainwater tank rainfall characteristics optimal tank size net financial benefit gained rainwater harvesting detailed sensitivity analysis elsevier rights reserved
herein rod like zno nanostructures synthesized via novel hydrothermal route using oac ethylenediamine hydrazine new set starting reagents synthesized products characterized techniques including xrd eds sem xps ftir prepared zno nanostructures utilized shell tio film dsscs effect precursor type morphology thickness zno shell number electrophoresis cycle solar cells efficiency well studied results showed ethylenediamine crucial effect morphology synthesized zno nanostructures using zno nanostructures leads increase dsscs efficiency compared bare tio similar improvement moreover highest amount solar cell efficiency obtained using zno nanorods two cycle electrophoresis deposition
new method estimating nonparametric time variant frequency response function frf variance hybrid time varying system proposed para meterizing hybrid time variation using legendre polynomials haar multiresolution wavelets frf identification problem reduced time invariant frf estimation problem stepwise regression method akaike information criterion applied select significant basis functions without manual intervention method achieve high estimation accuracy small uncertainty without requiring prior knowledge time variation system dynamics simulations experiment included illustrate method
aspergillus lateral flow device lfd recently introduced practical tool diagnosis invasive aspergillosis investigated performance aspergillus lfd point care test diagnosis serum samples collected twice weekly patients received intensive chemotherapy acute leukemia recepients allogeneic stem cell transplantation aspergillus galactomannan antigen beta glucan aspergillus lfd tests carried according manufacturers recommendations testing repeated modified procedure proven increase sensitivity aspergillus lfd performed without applying pretreatment procedure allow kit fit point care test fungal infections categorized according european organization research treatment cancer invasive fungal infections cooperative group national institute allergy infectious diseases mycoses study group eortc msg criteria total neutropenia episodes patients prospectively followed february january probable diagnosed patients probable pulmonary fungal disease diagnosed one patient rhinocerebral aspergillosis diagnosed one patient fungemia detected two patients aspergillus lfd positive serum patient probable bronchoalveolar lavage fluid patient probable aspergillus lfd false positive serum two patients although radiological finding documented fungemia fever resolved empirical caspofungin therapy one patients sensitivity aspergillus lfd point care test without pretreatment serum sample low
pythagorean normal surfaces defined rational surfaces admitting rational offsets important industrial computer aided design traditionally surfaces considered point view laguerre geometry using three main models cyclographic model blaschke cylinder isotropic model propose unifying formalism deal surfaces models embedded one ambient pseudo euclidean space known model lie sphere geometry various relations different models described terms closed formulas geometric algebra illustrated examples applications
paper presents structure principle operation improved howland current pumps voltage controlled current sources vccss grounded load particular review vccs employing power operational amplifier amp vccs using low power amp additional power transistor extending working dynamic range basis analysis operational principle equations transfer functions circuits formulas related dynamic electrical parameters obtained moreover using formulas design procedure developed recommendations simulation modelling given efficiency proposed procedure verified simulation modelling experimental testing sample electronic circuits vccss copyright john wiley sons ltd
investigated adolescent prosocial relations examining social networks based question helps homework repairing flat bicycle tire feeling effects individual characteristics academic achievement symptoms depressive mood peer status receiving help giving help examined investigated contribution dis similarity adolescents development prosocial relations gender structural network characteristics friendship relations taken account data derived social network analysis risk behavior early adolescence snare study contained information students secondary school classes across waves age boys results longitudinal social network analyses rsiena revealed tendencies toward reciprocation help exchange help within helping groups furthermore boys less often mentioned helpers particularly girls depressed adolescents less often mentioned helpers especially low depressed peers moreover lower academic achievers indicated received help higher achieving peers rejected adolescents received help often less often helped low rejected peers last low high popular adolescents less often helped also high popular adolescents less often helped findings show dis similarity characteristics important driving factor underlying emergence development prosocial relations peer context prosocial behavior defined terms benefitting particular others
mirabegron first selective beta adrenoceptor agonist treatment overactive bladder oab inhibits cytochrome isozyme cypd study performed japanese healthy postmenopausal female volunteers assess pharmacokinetic drug interaction mirabegron tolterodine another oab drug sensitive substrate cypd tolterodine orally administered days administered mirabegron days mirabegron increased maximum concentration max area concentration time curve zero dosing auc tolterodine fold confidence interval fold respectively increased cmax auch metabolite hydroxymethyl tolterodine fold fold respectively suggested weak pharmacokinetic drug interaction mirabegron tolterodine mean change baseline fridericia correction formula delta qtcf slightly higher day day subject qtcf msec delta qtcf msec treatment emergent adverse events mild mirabegron considered safe well tolerated coadministered tolterodine healthy postmenopausal female volunteers japanese society study xenobiotics published elsevier ltd rights reserved
pumped storage power station psps special power source flexible operation modes multiple functions rapid economic development china energy demand peak valley load difference power grid continuing increase moreover wind power nuclear power new energy sources also develop fast developing psps great importance power source structure adjustment secure stable operation power grids china century paper provides survey psps development china last two decades china psps developed quickly psps installed capacity reached gigawatts end ranking among top world pspss completed put production many installed capacity megawatts still construction including fengning psps addition lot sites suitable psps construction planned regard challenges existing exploitation course suggestions proposed bright future psps development china
purpose drug addiction psychiatric disorders frequently concomitant however studies investigated impact psychiatric disorders substance use disorder sud health related quality life hrqol drug users treatment studied association psychiatric disorders sud hrqol street recruited sample cocaine heroin users methods cross sectional study involving young users cocaine heroin barcelona spain hrqol assessed nottingham health profile nhp patterns drug use mental disorders assessed using spanish version psychiatric research interview substance mental disorders degree dependence severity dependence scale sds association mental disorders hrqol assessed tobit regression analysis results overall nhp score range sixty one percent sample two suds least one non sud axis disorder anxiety mood psychotic eating disorder borderline personality disorder bpd antisocial personality disorder variables negatively associated global nhp score psychosis transformed beta coefficient confidence interval bpd severity dependence two suds two three suds suds intravenous use substance conclusion hrqol among street recruited illegal substance users impaired particularly among psychiatric comorbidity psychosis bpd especially relevant
work report recent results long lasting educational project carrying several years evolving continuously objective mentioned project making students work production small yet full featured software prototypes collaborative approach dedicated development environment suited tools facilities time seek lay foundations build pragmatic model teach cognitive computing programming conducted experience programming course university naples federico exploiting software development environment based platform service paas made possible perform set cooperative learning activities used demonstrate practically theoretical concepts also stressing use cognitive computing tools introduce new way thinking software design process inception educational project involved relevant number students growing continuously year year first attempts students assigned specific activity expected concluded within one year new classes arrived seen possible start new activities starting precedent achievements thus requiring evolutions available prototypes allowed creating complex complete projects new tools services made available carrying new opportunities present release evolutionary path led using ibm bluemix platform wide range components including watson devoted cognitive computing work goes direction developing smart university model using innovative intelligent services help raising new generation software engineers also promote disseminate new way designing building innovative applications
paper optimum thermal thermodynamic operating conditions parabolic trough solar energy system working copper therminol silver therminol alo therminol nanofluids heat transfer fluids investigated moreover influence increasing concentration ratios thermal thermodynamic optimum conditions considered concentration ratios obtain system precise thermal thermodynamic performance well validated numerical model typical heat flux profile outer wall receiver absorber tube developed using finite volume based computational fluid dynamics tool together monte carlo ray tracing results show silver therminol nanofluid gives highest thermal performance owing comparatively better thermal transport properties whereas alo therminol showed lowest thermal performance given increase useful energy gain collector heat transfer enhancement thermal efficiency shown increase silver therminol copper therminol alo therminol respectively concentration ratio increasing concentration ratios increase thermal efficiency concentration ratio shown higher increase concentration ratio optimal thermal performance nearly flow rate nanofluids concentration ratios optimal thermodynamic performance low exergy destruction mainly dependent inlet temperature used correlations reynolds numbers give improved thermodynamic performance derived presented elsevier ltd rights reserved
feature extraction tracking fundamental operation used many geoscience applications paper present scalable method computing tracking features distributed memory machines large scale geospatial data carefully apply new communication schemes minimize data exchanged among computing nodes building updating global connectivity information features present theoretical complexity analysis show method significantly reduce communication cost compared traditional method
traditional assumption within research literature human sexually dimorphic traits many sex differences arisen intersexual selection recently however shift toward idea many male features including male lower pitched voices male beard growth might arisen predominantly intrasexual selection serve purpose male male competition instead mate attraction study using unique set video stimuli measured people perceptions dominance attractiveness men differ terms voice pitch levels lower higher pitched beard growth levels clean shaven month hair growth found nonlinear relationship lower pitch increased attractiveness men vocal attractiveness peaked around beard growth equivocal effects attractiveness judgments contrast perceptions men dominance simply increased increasing masculinity lower pitched voices greater beard growth together results suggest optimal level physical masculinity might differ depending whether outcome social dominance mate attraction dual selection pressures might maintain documented variability male physical behavioral masculinity see today
chimeric antibodies anti rituximab rtx anti tnfa infliximab ifx induce antidrug antibodies adas many patients inflammatory diseases key role lymphocytes initiation antibody responses localized cell epitopes rtx ifx perspective anticipate immunogenicity therapeutic antibodies identification cell epitopes performed using cells collected healthy donors nine cell epitopes identified variable chains antibodies deriving cell lines raised either rtx ifx cell epitopes often exhibited good affinity human leukocyte antigen hla molecules part peptides identified mhc associated peptide proteomics assay hla molecules dendritic cells dcs loaded antibodies two third cell epitopes identified healthy donors stimulated peripheral blood mononuclear cells patients developed adas rtx ifx promoted secretion diversity cytokines data emphasize predictive value evaluating cell repertoire healthy donors composition peptides bound hla dcs anticipate prevent immunogenicity therapeutic antibodies
paper propose new fractional jacobi elliptic equation method seek exact solutions fractional partial differential equations based traveling wave transformation certain fractional partial differential equation turned another fractional ordinary differential equation fractional jacobi elliptic equation used auxiliary sub equation solve fractional ordinary differential equation applications method apply seek exact solutions space time fractional kortweg vries kdv equation space time fractional benjamin bona mahony bbm equation space time fractional dimensional breaking soliton equations aid symbolic computation program series exact solutions expressed jacobi elliptic functions two equations successfully found
introduction rapid cognitive decline rcd occurs dementia due alzheimer disease methods literature review consensus meetings retrospective chart review patients probable conducted results literature review showed rcd definitions varied mini mental state examination scores treatment onset vascular risk factors age points year common moderate mild patients rapid slow decliners similar age gender education levels baseline discussion rcd sufficiently common interfere randomized clinical trials propose month prerandomization determination decline rate use rcd risk score ensure balanced allocation among treatment groups alzheimer association published elsevier inc rights reserved
simple new device dry separation fine particulate matter bulk soil samples presented consists stainless steel tube along nitrogen flow imposed resulting displacement particles taking account particle transport fluid mechanics soil sample composition tube long diameter found best adapted separation device rapidly produced several milligrams particulate matter chemical extractions edta subsequently performed study kinetic parameters extractable metals new caledonian mining soils chosen case study although easily extracted metal pool represents total metal content elements studied total concentrations extremely high pool therefore far negligible troublesome environment dry technique fine particle separation bulk parent soil eliminates metal leaching risks inherent wet filtration therefore ensure safe assessment environmental quality fine textured metal contaminated soils
efficient liquid cooling systems cutting chipping processes essential remain temperature limits cutting tool materials impinging jet cooling near processing location widely employed technique purpose cooling effect optimized using pulsating cooling fluid improve heat transfer via periodic renewal hydrodynamic thermal boundary layer study focuses cooling nozzle generates passive jet excitation without electric motor valve system four different nozzle design mechanisms jet excitation developed tested respect passively generated pulsation strouhal number pressure fluctuation pulsation amplitude measured strouhal number close achieved one excitation mechanism strouhal number achieved mechanisms authors published elsevier ltd
background opioid maintenance treatment omt regarded crime control measure yet individuals charged violent criminal offenses enrolled omt article aims generate nuanced knowledge violent crime among group imprisoned omt enrolled individuals exploring understandings role substances violent crime prior omt moral values related violent crime post crime processing moral transgressions methods twenty eight semi structured interviews undertaken among omt enrolled prisoners interviews audio recorded transcribed verbatim exploratory thematic analysis carried reflexive interactive approach findings prior omt substances particular high dose benzodiazepines deliberately used induce antisocial selves capable transgressing individual moral codes performing non violent violent criminal acts mainly support costly heroin use omt impulsive uncontrolled substance use prior violent acts participants imprisoned reported yet conduct violent criminal act necessarily imply one without moral principles study participants maintain moral standards engage complex moral negotiations struggle reconcile moral transgressions benzodiazepines also used reduce memories alleviate guilt associated committed violent crimes conclusions substances used transgress moral codes prior committing neutralize shame guilt experienced committed violent crimes simultaneously enrolled omt imprisoned violent crime might evoke feelings double shame guilt criminal behavior prior treatment actual case one imprisoned omt treatment providers identify individuals histories violent behavior together explore concrete episodes violence emotional reactions particular attention given potential relationships substance use violence treatment approaches tailored accordingly appears severe antisocial personality disorder may partly explained substance use
research examining child abuse neglect profiles among adult offender populations lacking therefore primary aim present study address limitation using latent class analysis lca identify meaningful classes individuals experienced physical abuse emotional abuse sexual abuse well neglect another aim estimate association class membership external criteria psychopathy factors self esteem attitudes towards male sexual violence dating relationships child sexual abuse myth acceptance violent offending age data collected among large systematically selected sample adult male inmates based lca three unique classes distinguished including low abuse group sample high physical emotional abuse group poly victimized group analysis revealed classes differentially associated affective responsiveness cognitive responsiveness personal self esteem prison self esteem attitudes towards male sexual violence dating relationships violent offending findings highlight unique nature constellations among criminal justice involved participants significance present results discussed relation past future research potential contributions treatment strategies also presented elsevier ltd rights reserved
pursuit economic clinical value oncology goes beyond pill encompass improvements process caring patients suffering cancer concept value based payment thus extends beyond amounts reimbursed drugs encompass methods payment used physicians facilities drugs prescribed delivered oncology payment mechanisms vary widely across nations depending structure health care systems challenges appropriate drug selection patient engagement common paper describes contemporary efforts create stronger payment incentives appropriate drug selection administration monitoring management united states france elsevier ltd rights reserved
electrolytic cells electrochemical oxygen demand ecod measurements based total electrolytic decomposition boron doped diamond bdd electrode developed rapid measurement organic pollutants low concentrations using improved electrolytic cells designed efficient mass transfer ecod potassium hydrogen phthalate theoretical ecod determined relatively short electrolysis time thus ecod measurements using cells would useful estimating organic water pollution industrial waste lake water
several studies suggested contingent adult imitation increase nonverbal communication attention proximity adults children autism spectrum disorders however studies shown effect contingent imitation verbal communication study examined whether children autism able promote verbal interaction vocal imitation vocalization vocal turn taking via contingent imitation used alternating treatment design composed conditions contingent imitation control six children autism aged months contingent imitation condition adults imitated children vocalization immediately control condition adults imitate gave vocal response immediately results showed contingent imitation condition children increased number vocal imitations vocal turn takings compared control condition number vocalizations increased condition children overall suggested children promote verbal interaction via contingent imitation
frequent construction demolition buildings civil works causes excessive waste energy natural resources generally accepted asphalt concrete mixtures made recycled concrete aggregate rca promotes sustainable construction however analysis identifies environmental downside increased consumption bitumen mixtures therefore increased consumption fossil fuels technical solutions limit rca content mixtures control impurities control fraction used application pretreatments emerging potential tools limit consumption bitumen made rca management point view also propose policy revision technical specifications adapt technical standards particularities rca paper makes contribution joining engineering economic approaches order make proposals construction management using recycled materials economically feasible
aim oxytocin presents exciting potential target core symptoms autism spectrum disorder asd pharmacologically easily administered cost effective form possibly minimal adverse effects still major gaps area research paper reviewed randomized controlled trials rcts examining effects oxytocin administration social cognition restricted repetitive behaviors individuals asd method electronic literature searches conducted psycinfo pubmed web knowledge embase rcts published june results rcts included review studies examined social cognition reported improvements additionally one studies restricted repetitive behaviors reported improvements following oxytocin administration however results meta analyses suggest oxytocin significant effect domains conclusion previous evidence revealed mixed findings effects oxytocin asd given limited number rcts summary findings effectiveness oxytocin asd still considered tentative
objective explore whether participating benefits effective exercise knee pain beep trial training program increased physiotherapists self confidence changed intended clinical behavior regarding exercise knee pain older adults design training program evaluation physiotherapists asked complete questionnaire beep trial training program immediately months later postintervention delivery beep trial questionnaire included case vignette associated clinical management questions questionnaire responses compared time physiotherapists trained deliver intervention within beep trial setting primary care participants physiotherapists completed beep trial training program interventions applicable main outcome measures self confidence diagnosis management knee pain older adults intended clinicalbehavior measured case vignette associated clinical management questions results fifty two physiotherapists returned pretraining questionnaire returned posttraining postintervention questionnaires respectively posttraining self confidence managing older adults knee pain increased intended clinical behavior regarding exercise knee pain older adults appeared line clinical guidelines however positive changes maintained longer term conclusions participating beep trial training program increased physiotherapists self confidence changed intended clinical behavior regarding exercise knee pain months later positive changes lost suggests brief training programs useful additional strategies likely needed successfully maintain changes clinical behavior time american congress rehabilitation medicine
creating sense interpersonal similarity attitudes values associated increased attraction liking applying findings intergroup setting though yielded mixed support theorizing social identity perspective suggests highlighting intergroup similarity may lead increased antipathy extent perceived threat one unique social identity circumvent process examine influence emotional similarity rather attitudinal value similarity expectation short term nature emotions may evoke less threat one social identity moreover given importance emotions intergroup humanization processes expected emotional similarity would associated greater conciliatory attitudes due increase humanization outgroup report results two studies supporting predictions following exposure anger eliciting news story jewish israeli participants given information emotional reaction story similar individual member outgroup study palestinian citizen israel outgroup whole study palestinians west bank predicted emotional similarity associated increased humanization outgroup subsequent increase one willingness support conciliatory political policies toward outgroup conclude emotional similarity may productive avenue future intergroup interventions particularly groups differences attitudes values foundational intergroup conflict
series polycaprolactone pcl polyols synthesiied via ring opening reaction epsilon caprolactone initiated small molecular polyols including ethylene glycol butanediol bdo diethylene glycol deg neopentyl glycol npg diethyl pentanediol cyclohexanedimethanol chdm trimethylolpropane tmp trimethylolpropane tmp pentaerythritol maltitol nmr spectra pcls disclosed epsilon caprolactone reacted hydroxyl groups small molecular polyols target pcls successfully prepared possessed similar molecular skeleton structures gpc data summarized measured number average molecular weights pcls approached theoretical values polydispersity indexes pdi ranged pcls prepared maltitol displayed highest viscosity mpa products obtained diol substrates including bdo deg npg exhibited lower viscosities range mpa cured films pcls prepared polyisocyanate curing agents exhibited good impact resistance adhesion flexibility higher hardness displayed better thermal stability weight loss degrees pcls obtained tmp pcl tmp epsilon tmp pcl tmp epsilon exhibited higher films hardness lower viscosities solid content viscosities pcl pcl mpa respectively voc contents spray applied coatings prepared pcl pcl low elsevier rights reserved
order protect bolts corrosion electroplating zinc plating widely used however hydrogen easily penetrate diffuse vacancies dislocations lattices bolt steel electroplating diffused hydrogen defects inside lattice gaseous form small cracks easily produced due high pressure hydrogen gas research order determine root cause fracture pole fastening screws resulting hydrogen embrittlement typical electric motors additional factors accelerate hydrogen embrittlement fracture selectively applied including small fillet head shank transition excessive hardness parametric study performed experimentally elsevier ltd rights reserved
background peel citrus reticulata blanco traditionally used tonic stomachic astringent carminative also useful skin care objective study anti aging potential alcoholic extracts reticulata blanco peel using vitro antioxidant anti enzyme assays materials methods plant extracts obtained soxhlation hae hot alcoholic extract citrus reticulata maceration method cae cold alcoholic extract citrus reticulata qualitative quantitative phytochemical analysis performed vitro antioxidant anti enzyme gas chromatography mass spectrometry analyses performed results total phenolic flavonoid contents hae found higher cae ecvalue hae cae diphenyl picrylhydrazyl superoxide anion azino bis ethylbenzothiazoline sulfonic acid assays respectively oxygen radical absorbance capacity values hae cae found moles hydroxy tetra methylchromane carboxylic acid equivalent substance respectively anti collagenase anti elastase activities evaluated hae cae ecvalues hae cae anti collagenase anti elastase respectively hae exhibited stronger anti collagenase anti elastase activity cae analysis hae carried hae exhibited higher antioxidant anti enzyme potential cae conclusion reticulata peel utilized anti wrinkle skin care formulations summaryskin anti aging potential citrus reticulata blanco peel evaluated throughin vitro antioxidant anti enzyme assaystwo types extraction performed extracts subjected qualitative quantitative phytochemical analysis extract obtained soxhlation hae showed higher total phenolic flavonoid contents extract obtained maceration cae hae demonstrated strong dpph superoxide free radical scavenging activity whereas abts scavenging activity extracts found similar oxygen radical absorbance capacity orac hae found indicating strong antioxidant potentialin vitro collagenase elastase enzyme inhibition activities evaluated extracts hae showed strong anti collagenase anti elastase potential indicating anti aging abilitygc analysis hae revealed presence various compounds mainly including polymethoxyflavones hae exhibited promising antioxidant anti enzymatic activity used potent anti wrinkle agent anti aging skin care formulations abbreviation used ecm extracellular matrix ultra violet ros reactive oxygen species mmp matrix metalloproteinase chc clostridium histolyticum collagenase dpph diphenyl picrylhydrazyl gas chromatography mass spectroscopy room temperature gae microgram gallic acid equivalent milligram weight volume microgram quercetin equivalent milligram hae hot alcoholic extract citrus reticulata blanco cae cold alcoholic extract citrus reticulata blanco half maximal effective concentration pms nadh phenazine methosulfate nicotinamide adenine dinucleotide nbt nitroblue tetrazolium dmso dimethyl sulfoxide aps ammonium persulphate aaph azobis amidino propane dihydrochloride trolox hydroxy tetramethyl chromane carboxylic acid orac oxygen radical absorbance capacity falgpa furyl acryloyl leu gly pro ala sana succinyl ala ala ala nitroanilide retardation factor msd mass selective detector
size scale effects oil mechanical properties materials important topic engineering design recent years great deal research size scale effects carried order gain precise description phenomenon highlight physical mechanisms lie behind three different approaches proposed least analyzed include statistical weibull statistical theory strength materials proceedings royal swedish institute engineering research energetical bazant size effect blunt fracture concrete rock metal journal engineering mechanics asme fractal approach carpinetri fractal nature material microstructure size effects oil apparent mechanical properties mechanics materials internal report laboratory fracture mechanics politecnico torino carpinteri scaling laws renormalization group strength toughness disordered materials international journal solids structures fractal approach exploits fractal nature fracture molosov borodich fractal fracture brittle bodies compression soviet physics doklady matter intense debate particularly papers bazant scaling quasibrittle fracture fractal question journal materials technology asme scaling quasibrittle fracture hypotheses invasive lacunar fractality critique weibull connection international journal fracture statistical fractal aspects size effect quasibrittle structures shiraishi editor structural safety reliability rotterdam balkema borodich fractals fractal scaling fracture mechanics international journal fracture bazant yavari cause size effect structural strength fractal energetic statistical engineering fracture mechanics recently saouma fava fractals size effects international journal fracture question validity even argue lacks sound physical mathematical basis long standing controversy interpretation scaling laws material strength carpinteri pugno scaling laws oil strength solids related mechanics geometry nature materials fractal approach counterposed energetical approach first called energetical statistical one recently aim paper revisit fractal approach reject recurrent criticisms moreover show wrong set fractal approach size scale effects statistical one since deeply connected shown several papers carpinteri cornetti size effects oil concrete tensile fracture properties ail interpretation fractal approach based aggregate grading journal mechanical behavior materials carpinteri cornetti puzzi stereological analysis aggregate grading size effect oil concrete tensile strength international journal fracture carpinteri cornetti puzzi scale effects strength toughness grained materials extreme value theory approach strength fracture complexity carpinteri cornetti puzzi size effect upon grained materials tensile strength increase statistical dispersion smaller scales theoretical applied fracture mechanics analyzing detail fractal distribution micro cracks frame work extreme value theory obtain scaling law tensile strength characterized logarithmic plot slope conversely considering fractal grain size distribution grained material obtain scaling law fracture energy characterized logarithmic plot positive slope slopes natural consequence perfect self similarity flaw grain size distribution finally theoretical results regarding link fractals statistics confirmed numerical simulations elsevier ltd rights reserved
developing legally compliant systems challenging software engineering problem especially systems governed law healthcare information systems challenge comes ambiguities domain specific definitions found governmental rules therefore significant business need automatically analyze privacy texts extract rules subsequently enforce throughout supply chain existing works analyze health regulations use health insurance portability accountability act case study article applied breaux anton approach text saudi arabian healthcare privacy regulations saudi arabia privacy among top dilemmas public private healthcare practitioners result extracted analyzed rights obligations constraints rules analysis assist requirements engineers standards organizations compliance officers stakeholders ensuring systems conform saudi policy addition article discusses threats study validity suggests open problems future research
reactive oxygen species generated product metabolism play central role development obesity obesity related metabolic complications objective current study explore possibility block obesity improve metabolic homeostasis via phloretin natural antioxidant product apple tree leaves manchurian apricot preventive therapeutic activities phloretin assessed using high fat diet induced obesity mouse model phloretin injected intraperitoneally twice weekly regular obese mice fed high fat diet effects phloretin treatment body weight composition fat content liver glucose lipid metabolism insulin resistance monitored compared control animals phloretin treatment significantly blocks high fat diet induced weight gain induce weight loss obese animals phloretin improved glucose homeostasis insulin sensitivity alleviated hepatic lipid accumulation pcr analysis showed phloretin treatment suppresses expression macrophage markers pro inflammatory genes mcp ccr enhances adiponectin gene expression white adipose tissue addition phloretin treatment elevated expression fatty acid oxidation genes carnitine palmitoyltransferase cpta cptb reduced expression monocyte chemoattractant protein mcp novo lipogenesis transcriptional factor peroxisome proliferator activated receptor gamma ppar gamma target monoacylglycerol acyltransferase mgat genes results provide direct evidence support possible use phloretin mitigation obesity maintenance metabolic homeostasis
black holes asymptotically flat space times negative specific heat get hotter loose energy clear statistical mechanical understanding remained challenge work address issue using fluid gravity correspondence aims associate fluid degrees freedom horizon using linear response theory teleological nature event horizon show explicitly fluctuations horizonfluid lead negative specific heat schwarzschild black hole also point specific heat positive kerr newman ads black holes approach constitutes important advance allows apply canonical ensemble approach study thermodynamics asymptotically flat black hole space times
cognitive processes specify understanding humans behavior communicative situations healthy controls schizophrenia patients presented social silent video clips performed flicker task predicted characters behavior experiment eye movements recorded observers made successful predictions evaluated characters actions specified categorized objects events profiled objects features categorizations based information features remained working memory directed communicative situation perception observers noticed events relevant viewpoints characters understood gazes gestures actions made unsuccessful predictions advanced hypotheses characters categorized objects events profile objects features categorizations based demonstrated blindness events relevant viewpoints characters understand coherence actions
hepatitis virus hcv envelope glycoprotein complex composed subunits receptor binding protein well major target neutralizing antibodies whereas functions remain poorly defined took advantage recently published structure terminal region ectodomain interrogate functions glycoprotein mutating residues within amino acid region context infectious clone phenotypes mutants characterized determine effects mutations virus entry replication assembly furthermore biochemical approaches also used characterize folding assembly heterodimers thirteen mutations led viral attenuation inactivation interestingly two attenuated mutants less dependent claudin cellular entry huh cells instead viruses relied claudin indicating shift receptor dependence two mutants target cell line unexpected phenotype also observed mutant longer infectious still showed good level core protein secretion furthermore genomic rna absent noninfectious viral particles indicating mutation leads assembly release viral particles devoid genomic rna finally change subcellular colocalization hcv rna observed mutant unique observation highlights first time cross talk hcv glycoprotein genomic rna hcv morphogenesis importance hepatitis virus hcv infection major public health problem worldwide encodes two envelope proteins play major role life cycle virus extensively characterized whereas remains poorly understood investigated functions using site directed mutagenesis context viral life cycle results identify unique phenotypes unexpectedly two mutants clearly showed shift receptor dependence cell entry highlighting role modulating hcv particle interaction cellular receptor importantly another mutant led assembly release viral particles devoid genomic rna unique phenotype characterized observed change subcellular colocalization hcv rna unique observation highlights first time cross talk viral envelope protein genomic rna morphogenesis
smart meter key part smart grid responsible collecting user characteristics advanced metering infrastructure applications upgraded ipv protocol lowpan potentially replace zigbee standard protocol internet things area representing application ipv technology smart metering article introduces design electricity information acquisition module stm microprocessor transmitter receiver embedded module lan set data transmission based lowpan individual system tests advanced module shown robustness interference immunity high network stability lower power consumption comparing modules different hardware operating systems
water management regulation buildings facing real challenges increasing environmental awareness last decades current concerns shortage water resources increase demands enhance water management strategies respect buildings able gain conserve transport lose water adequately efficient water management solutions extracted strategies found nature classify basic array strategies water management discuss morphological features active means list corresponding examples nature facilitate search selection strategies large database nature inspire new design solutions authors published elsevier ltd open access article license
due adverse effects fossil fuel use becoming increasingly important produce next generation biofuels renewable sustainable sources filamentous fixing strains cyanobacteria emerged promising industrial microorganisms capable producing range biofuels chemicals using water sunlight study life cycle analysis lca conducted hypothetical production facility uses genetically engineered strain filamentous cyanobacteria produce cyclic hydrocarbon limonene two scenarios evaluated difference scenarios limonene productivity engineered cyanobacteria strain scenario cyanobacterium assumed produce limonene rate resulting annual production limonene scenario limonene productivity resulting annual production scenarios assumed produce amount cellular biomass converted biogas anaerobic digestion biogas converted gas turbines electricity power facility excess electricity assumed sold grid major environmental burdens facility measured eco points calculated based eco indicator method cyanobacteria nutrient supply especially sodium nitrate photobioreactor pbr electrical requirements lower output limonene scenario meant less energy required product recovery leaving electricity sale grid even though higher limonene productivity worsen environmental profile process scenarios described study less negative environmental impact biodiesel production study strongly suggests scenarios theoretical limonene production facility described herein holds great potential future solution producing next generation biofuels directly solar energy elsevier rights reserved
many interface events problems occur construction phase construction projects tracking controlling essential construction management interface management become important aspect sound project management strategy affects project cost scheduling quality directly indirectly construction projects interface changed events identified tracked using construction processes improved minimizing rework reducing total project duration despite many studies discussions academic practical literature systematic approaches information platforms managing interface events problems construction lacking study tracks manages interface events using novel three dimensional interface maps integrated building information modelling bim approach bim approach utilized retain interface information digital format facilitates easy interface updating transfer cad environment based interface maps provide users overview interface events given construction project users track manage interfaces virtually primary purpose study develop web construction bim based conbim system engineers enhance interface information sharing efficiency tracking construction projects conbim system applied case study building project taiwan verify efficacy demonstrate effectiveness case study results show conbim system effective managing interfaces using bim approach construction
paper presents servo control problem pneumatic artificial muscle pam powered hydrogen based metal hydride mechanical servo actuation various operations servo pam actuator driven hydrogen based desired task actuator changed following various operations fuzzy adaptive proportional integral derivative pid controller proposed improve dynamic performance requirements transient steady state responses fuzzy logic part proposed controller employed better conventional pid automatic online tuning parameters pid gain different operating conditions nonlinear mathematical model pam actuated hydrogen based determined desired characteristics closed loop control fuzzy rule base position control examined illustrate performance proposed controller results show proposed technique suitable effective case servo actuation
low commitment teaching amongst teachers problem facing teaching profession many countries gender might important factor explaining kinds prospective teachers attracted teaching empirical study examined relationship student teachers gender gender roles commitment teaching within context large university based teacher education program tanzania self report questionnaire administered comprising commitment teaching items gender demographic variable items bem sex role inventory bsri cluster analysis masculine feminine scale bsri indicated three clusters highly androgynous students high scores masculine feminine scales medium androgynous students relatively high scores masculine feminine scales low androgynous students low scores relation two groups masculine feminine scales bsri female male student teachers reported highly androgynous covariance analysis showed gender roles significantly related commitment teaching intention enter teaching profession highly androgynous student teachers reported significantly commitment teaching higher intentions enter teaching profession compared medium low androgynous student teachers significant relationships found gender one hand commitment teaching intention enter teaching profession hand findings discussed context teacher teacher education tanzania
paper presents development fault detection diagnosis fdd system use diesel internal combustion engine ice valve train novel feature generated valve closing combustion impacts deformed valve spring faults abnormal valve clearance faults seeded diesel engine instrumented one accelerometer five classification methods implemented experimentally compared fdd system using naive bayes classification method produced best overall performance lowest detection accuracy lowest classification accuracy spring faults occurring individual valves lowest values multiple faults occurring simultaneously respectively results demonstrate accuracy fdd system diesel ice valve train fault scenarios previously addressed literature elsevier ltd rights reserved
hadoop hdfs open source project apache software foundation scalable distributed computing data storage hdfs become critical component today cloud computing environment wide range applications built top however initial design hdfs introduced single point failure since hdfs contains one active namenode namenode experiences software hardware failures whole hdfs cluster unusable reason people reluctant deploy hdfs application whose requirement high availability paper present solution enable high availability hdfs namenode efficient metadata replication solution major advantages existing ones utilize multiple active namenodes instead one build cluster serve requests metadata simultaneously implement pub sub system handle metadata replication process across active namonodes efficiently also propose novel replication algorithm deal network delay namonodes deployed different areas based solution build prototype called ncluster integrate hdfs evaluate ncluster exhibit feasibility effectiveness experimental results show solution performs well low replication cost good throughput scalability
problem based learning pbl one effective methods instruction helps visual effects vfx students adaptable encountering career challenges malaysia challenges lack several important requirements basic fundamental knowledge vfx concepts ability understand real world problems convert ideas vfx solutions ability attain retain date knowledge vfx concepts perhaps importantly ability come solutions real world problems role helping students thus encompasses improving level meaningfulness learning experience skills terms comprehension knowledge retention problem solving self directed learning well interpersonal skills use pbl helps vfx students cope encounters career challenges malaysia may enhanced focusing faculty wide approach compared applying course time moreover methods enhancing vfx education delivery malaysia encourage reflective practices pbl based dialogues vfx increase level vfx competence instructors improved training methods
much known children acquire understanding mental states experiments identify social contexts children tend use capacity dispositions influence usage social exclusion common situation compels reconnect new parties may crucially involve attending parties mental states across two studies line inquiry extended typically developing preschoolers study young children without anxiety disorder study children played virtual game toss cyberball ostensibly internet two peers first played fair inclusion eventually threw balls child exclusion cyberball children studies completed stories peer scenarios study typically developing year olds randomly assigned regular exclusion apparent reason accidental exclusion due alleged computer malfunction compared accidental exclusion regular exclusion led children portray story characters strongly intentional agents intentionality use mental state language msl character affiliation post cyberball stories study clinically referred year olds age gender matched non anxious controls completed stories regular exclusion replicated post regular exclusion increase intentional msl portrayals story characters among non anxious controls anxious children exhibited decline dimensions regular exclusion conclude exclusion typically induces young children mentalize enabling effective reconnection others however excessive anxiety may impair controlled mentalizing may turn hamper effective reconnection others exclusion
background consultations primary care allergies common difficult differentiate ige mediated atopic symptoms respond allergen specific interventions non atopic without performing objective tests largely unavailable general practice aim develop test screening tool accurately discriminate atopic non atopic individuals design setting validation study took place adult volunteers aged years scotland method questionnaire screening tool developed using questions large cohort study consultation experts participants answered questions skin prick tests four aeroallergens house dust mite cat dog mixed grasses participants classified atopic average wheal diameter bigger negative control sensitivity specificity positive negative predictive values individual combinations questions calculated results participants completed questionnaire underwent skin prick testing atopic negative predictive values individual questions ranged atopic negative answers optimum combination four questions identified negative answer four questions reported participants atopic conclusion authors identified set questions correctly predict negative skin prick tests common aeroallergens time may useful exclude patients warrant investigation reliably advised allergen avoidance neither necessary helpful
objective aimed identify association carotid atherosclerosis traditional risk factors disease features cytokine profile calprotectin patients primary sjogren syndrome pss methods primary pss patients age sex matched healthy controls underwent carotid ultrasound clinical laboratory examination presence carotid plaques taken carotid atherosclerosis covariates carotid atherosclerosis identified univariate multivariate regressions results patients pss higher prevalence carotid atherosclerosis univariate analyses serum calprotectin traditional cardiovascular age male sex metabolic syndrome hypertension hypertriglyceridaemia serum creatinine disease associated risk factors glucocorticoid saliva substitute use constitutional domain enlar sjogren syndrome disease activity index eular associated higher risk plaque multivariate analysis pss higher serum calprotectin associated carotid atherosclerosis independent traditional risk factors conclusion pss higher prevalence carotid atherosclerosis associated higher serum calprotectin level independent traditional cardiovascular risk factors findings suggest calprotectin biomarker subclinical atherosclerosis pss
introduction oral testosterone found reduce plasma levels hdl cholesterol previous study examined effect fibrates known increase hdl cholesterol patients low testosterone levels requiring testosterone replacement aimsthe study included three age weight lipid matched groups older men atherogenic dyslipidemia late onset hypogonadism treated oral testosterone undecanoate daily micronized fenofibrate daily testosterone plus fenofibrate plasma lipids glucose homeostasis markers well plasma levels androgens uric acid high sensitivity reactive protein hscrp homocysteine fibrinogen assessed weeks therapy resultsapart increase plasma testosterone reduction hdl cholesterol testosterone undecanoate tended decrease hscrp improve insulin sensitivity fenofibrate administered alone increased hdl cholesterol reduced triglycerides decreased insulin resistance reduced circulating levels uric acid hscrp fibrinogen well increased plasma levels homocysteine strongest effect testosterone homa uric acid hscrp fibrinogen observed fenofibrate administered together testosterone testosterone fenofibrate combination therapy also devoid unfavorable effect hdl cholesterol homocysteine conclusionsour study shows fenofibrate produces stronger effect cardiometabolic risk factors men late onset hypogonadism atherogenic dyslipidemia oral testosterone undecanoate obtained results suggest group patients may benefit combined treatment oral testosterone undecanoate micronized fenofibrate
hierarchically structured automatic voltage control avc architecture enables wide area closed loop coordinated voltage regulation cvr owing inherent complexity task cvr relies reduced control models simplified models system suitable voltage control fact however single reduced control model static rcm optimal network configurations operating conditions pursuit advanced online voltage control future smart transmission grid paper presents adaptive control model reduction adaptive rcm cvr proposed formulation based complex network representation transmission grid additionally formulation employs spectral clustering complemented perturbation theory deliver adaptive rcm indicative results presented new england bus network provide adequate justification proposed approach implications adaptive rcm scheme control algorithm design selection also discussed
analog ics widely used communication sense power systems spacecraft produced variety technologies cmos bicmos functional options paper provides tid degradation analysis common analog ics operational amplifiers voltage comparators linear stabilizers general trends radiation behavior recommendations analog radiation testing presented
search nutrient dense food source top priority today food challenged world multi billion population food insecurity become especially critical developing countries though potential sources functional foods wasted right eyes rose hips fruits rose plants rosa discovered rich polyphenols triterpene acids flavonoids proanthocyanidins catechin essential fatty acids galactolipid folate vitamin minerals among bioactive components extracts proven possess antioxidant anti inflammatory immunomodulation anticancer cardioprotective antidiabetic neuroprotective antimicrobial properties extracts validated beneficial non alcoholic fatty liver disease osteoarthritis rheumatoid arthritis obesity cancer kidney stone depression dermal issues among pathologies mechanisms therapeutic actions involve intervention cox inos kappab ppar gamma mapk bak caspase channel blockade pathways barring rosaceae family characteristic allergenicity due ltps rose hips free side effects holistic review based recent findings excited report rose hips emerging functional food deserves integrated food platter without delay elsevier ltd rights reserved
background according world health organization adolescents individuals aged years india years adolescents married adolescent girls years age begin child bearing adolescent pregnancies constitute total pregnancies india although abortion legal unsafe abortions account maternal deaths girls years health problems adolescents need personal friendly confidential advices reassurances medical personnel get clear insight health problems little medical intervention family life education adolescents current needs associated changing physical cognitive social emotional sexual developments promote fulfil anticipatory future family related needs preparing adult roles meet responsibilities marriage parenting aim know extent improvement knowledge menstruation menstrual hygiene practices amongst school going adolescent girls village krishna district educational intervention objective assess basal knowledge menstruation among school going adolescent girls assess impact reproductive health education special emphasis nutrition reproductive health materials methods study done adolescent girls zilla parishad high school nidamanuru village coming primary health centre area kankipadu krishna district andhra pradesh results interventional study conducted among adolescent high school girls students majority age group years two thirds study subjects hindus majority study subjects belong backward caste mothers girls primary secondary educational status majority study subjects belong class modified prasad socioeconomic status followed class iii followed class conclusion knowledge regarding various aspects menstruation poor educational intervention subsequently improved providing health education therefore family life education strictly implemented school college curriculum age appropriate topics include package information regarding small family norm gender discrimination domestic violence nutrition pubertal changes menstrual hygiene pregnancy abortion contraception unsafe sex hiv aids etc
fractionated frontal cortical grey matter human alzheimer disease control subjects four biochemically defined pools represent four distinct compartments soluble cytosolic peripheral membrane vesicular cargo integral lipid membranous pools aggregated insoluble debris readily extractable amyloid beta remains associated lipid membranous compartment exchange amyloid beta biochemical pools lost amyloid beta species alzheimer disease consistent peptide irreversibly trapped extracellular deposits quantitative amyloid beta data combined magnetic resonance imaging volumetric analysis amount cortical grey matter brain allowed estimate total mass amyloid beta alzheimer disease control brains threshold positron emission tomography standard uptake value ratio equates amyloid beta grey matter mean alzheimer disease dementia standard uptake value ratio level equates amyloid beta grey matter takes years accumulate amyloid threshold positron emission tomography standard uptake value ratio mean value observed alzheimer disease dementia accumulation time window combined difference amyloid beta alzheimer disease control brain allows first approximation amyloid beta accumulation equates estimated total amyloid beta production deposited insoluble plaques understanding rates amyloid beta accumulation allows quantitative approach targeting failure amyloid beta clearance sporadic alzheimer disease
power electronics pulse width modulation pwm inverter one families electrical circuits converts electrical supply one level another using semiconductor based electronic switches important characteristic types circuits switches operated one two states continuous conduction operations transitions cause switching power losses lead power loss pwm inverter purpose switch assist process transferring power source load power losses affect performance efficiency load overcome problems paper asymmetric space vector pulse width modulation asvpwm technique proposed proposed asvm additional voltage sectors switching states determined state transition matrix subsequently using proposed technique speed induction motor controlled error speed change error speed calculated using fuzzy logic controller flc output flc applied asvpwm inverter stability improved switching loss harmonics effect proposed asvpwm inverter analyzed
development computer aided resources automation generation manufacturing routings operations mainly accomplished search similarities existent ones resulting standard process routings grouped analysis similarities parts routings article proposes development manufacturing routings operations detailment using methodology steps define initial intermediate final operations starting rough piece going final specifications must binunivocal relationship part design specifications step use called rules precedence link chain routing operations rules precedence order prioritize knowledge various manufacturing processes taking account theories machining forging assembly heat treatments also utilizes theories accumulation tolerances process capabilities others also reinforced availability manufacturing databases related process tolerances deviations machine tool cutting tool fixturing devices workpiece process capabilities statement application rules precedence linking joining manufacturing concepts logical structured way application methodology steps make viable utilization structured knowledge instead tacit one currently available manufacturing engineering departments generation manufacturing routing operations consequently development computer aided process planning facilitated due structured knowledge applied methodology
primary myelofibrosis unique entity among bcr abl negative myeloproliferative diseases manifesting bone marrow fibrosis pancytopenia considerable evidence indicates genetic epigenetic abnormalities result defective clonal hematopoietic stem cell proliferation addition bone marrow microenvironment alteration bad seeds bad soil theory illustrates orchestrating efforts hematopoietic stem cells stromal cells surrounding signaling molecules myelofibrosis progression malignancy transformation though exact mechanism myelofibrosis still clear study reviews current concepts questions regarding pathogenesis primary myelofibrosis discusses emerging targeted therapy aimed restoring normal bone marrow environment halting bone marrow fibrotic deterioration
paper quadrature phase shift keying demodulator presented performs phase frequency synchronization analog domain presented demodulator utilized short range ultra wideband wireless communication scenarios greatly simplify wireless system relaxing demands digital signal processors demodulator implemented low cost system package module including narrow bandwidth microstrip bandpass filter teflon substrate analog carrier recovery synchronization experimentally characterized using custom designed modules formulti test signal generation furthermore shown presented carrier recovery concept exhibits efficient phase noise suppression results demonstrate successful coherent demodulation data rate high dynamic range robustness undesired phase frequency fluctuations
mechanisms childhood socioeconomic status cses affects adult mental health general health well clear moreover analytical assumptions employed assessing mediation social psychiatric epidemiology rarely explained aim paper explain intermediate confounding assumption quantify differential recall bias association cses childhood abuse mental health scl general health subjective well swls furthermore assessed mediating role psychological physical abuse association cses mental health general health well influence differential recall bias estimation total effects direct effects proportion mediated effects assumptions employed assessing mediation explained reference causal diagram poisson regression models relative risk cis used assess association cses psychological physical abuse childhood mediation analysis difference method used assess indirect effect cses psychological physical abuse childhood mental health general health well exposure cses measured two time points mediation assessed cross sectional longitudinal data psychological abuse physical abuse mediated association cses adult mental health general health well among men among women results suggest association cses childhood abuse association childhood abuse adult mental health general health well association cses adult mental health general health well driven differential recall bias assessing mediation cross sectional data exposure mediator outcome measured time showed total effects direct effects vastly overestimated biased upwards consequently proportion mediated effects underestimated biased downwards true unobserved direct indirect effect direction differential recall bias predictable results cross sectional analyses discussed light
present study explores preparation characterization role phenolic acid tethered fibrous protein management induced oxidative stress studied vitro conditions brief biomaterial prepared engineering fibrous protein dihydroxy trihydroxy phenolic acid moieties subjected characterization ensure tethering resultant biomaterial studied efficacy free radical scavenger using polymorphonuclear pmn cells induced oxidative stress also agent cell migration using fibroblasts cells results revealed induced oxidative stress pmn cells exposure uvb radiation managed well prepared biomaterial reducing levels superoxide anion oxygen hydroxyl radicals protein phenolic acid interaction supports cell migration evidenced scratch assay conclusion though phenolic acids well known antimicrobial antioxidant potential indenting acids directly wounds sensible tethering protein explored scavenging activity expected present study infers phenolic acid engineered protein significant role managing imbalance redox state prevailing wounds supports healing appreciable level elsevier rights reserved
studies addressed likely gene gene epistatic interactions mediating risk schizophrenia using preclinical genetic approach investigated whether simultaneous disruption risk factors neuregulin nrg disrupted schizophrenia disc would produce disease relevant phenotypic profile different observed following disruption either gene alone nrg heterozygotes exhibited hyperactivity disruption prepulse inhibition reversed antipsychotic treatment accompanied reduced striatal dopamine receptor protein expression impaired social cognition altered glutamatergic synaptic protein expression selected brain areas single gene disc mutants demonstrated disruption social cognition nest building altered brain hydroxytryptamine levels hippocampal erbb expression decreased cortical expression schizophrenia associated microrna mir disruption disc nrg indicative epistasis evoked impairment sociability enhanced self grooming accompanied changes hypothalamic oxytocin vasopressin gene expression findings indicate specific behavioral correlates underlying cellular pathways downstream main effects dna variation schizophrenia associated genes nrg disc
pharmacological inhibition kinase activity jail proteins interfere signaling immunomodulatory cytokines block constitutive activation jak stat pathway characterizes certain malignancies including chronic myeloproliferative neoplasms jak inhibitors may therefore useful treat malignancies well inflammatory immune disorders currently significant advances made treatment myelofibrosis drugs may lead remarkable improvement control hyperproliferative manifestations however available data suggest treatment curative myelofibrosis general jak inhibition induces cytopaenias considered class side effect contrast extrahaematologic toxicity profile varies significantly among different jak inhibitors present several clinical trials evaluating combination ruxolitinib drugs order improve therapeutic activity well reducing haematologic toxicity elsevier espana rights reserved
divorced parents face distinct challenges providing care chronically ill children children residence two households necessitates development family specific strategies ensure coparents supervision regimen adherence management children health care utilizing risk resilience perspective grounded theory study conducted divorced parents children chronic illnesses importance trust gender relationships third party care providers emerged key themes related development effective coparenting relationships maintaining children health divorced parents best able support management children chronic conditions care providers operated neutral third parties intermediaries collaborative family care may require health care practitioners avoid drawn contentious inter parental conflicts
background striatum important brain structure learning memory well motor cognitive skills abnormalities subcellular localization synaptic cell surface proteins occur within striatum parkinson disease study tested effects neurosteroid allopregnanolone allo restoration nigrostriatal pathway output ohda lesioned rats methods simulate hydroxydopamine ohda injected rat substantia nigra allo orally administered day ohda injection continued every day weeks motor skill learning motor behaviors assessed apomorphineinduced rotation accelerating rotarod beam balance beam walk bar tests levels striatal postsynaptic density protein psd neurexin well cyclooxygenase cox caspase proteins determined immunoblotting results data indicated allo significantly improved ohda induced motor impairment revealed increase ability remain rotating rod increase balancing crossing beam also decrease degree catalepsy bar test furthermore psd neurexin levels significantly decreased cox activated caspase increased striatum ohda treated animals mentioned molecular changes attenuated allo treatment conclusions data demonstrated allo protective effect ohda treated rats inhibits striatal inflammation apoptosis preserves pre post synaptic proteins maybe synaptic integrity nigrostriatal pathway elsevier masson sas rights reserved
compared standard representation recent violent computer game representation realized shutter goggles lab experiment assuming higher degree realism media violence would impact stronger players pretest posttest design analyzed influence violent video game exposure implicit explicit measures aggressiveness according explicit questionnaire aggressiveness participants reported becoming peaceful whereas implicit association test aggressiveness agg iat indicated association self aggressive behavior became stronger violence exposure confirming unique utility agg iats media research visualization mode however strengthen association mediation model increases aggressiveness participants flow experiences supported inspecting flow experiences interaction effect gender visualization mode evident male participants likely flow experiences high realism format whereas female participants likely experience flow standard mode discuss findings context automatic information processing aggression contend possible changes automatic behavioral precursors due media influence elsevier ltd rights reserved
use cache sensitive memory layouts improve search performance ordinary binary search trees without increasing time complexity insertion deletion approach require changes structure nodes rebalancing strategy tree cache sensitivity maintained memory layout invariant keeps given number neighboring nodes tree stored cache block show preserve using worst case constant time operations executed tree changes extensive experiments invariant consistently improved search performance large avl red black trees synthetic data well realistic search tree operations extracted database benchmark also compare binary search trees several cache sensitive trees non dynamic approaches laying tree nodes multi level memory hierarchy
effects prenatal low dose irradiation heavy ions embryonic development mice melanocyte differentiation well understood performed whole body irradiation pregnant cbl mice embryonic day single dose gamma rays silicon argon iron ions number living embryos embryonic body weight decreased exposure heavy ions high doses malformations small eyes limb anomalies observed heavy ion treated embryos gamma ray treated embryos frequency abnormally curved tails increased exposure gamma rays argon iron ions even dose contrast dose dependent decrease number epidermal melanoblasts melanocytes hair bulb melanocytes observed irradiation gamma rays heavy ions decrease number dorsal hair bulb melanocytes dorsal ventral epidermal melanoblasts melanocytes ventral hair bulb melanocytes necessarily correlated linear energy transfer radiation tested moreover effects heavy ions larger ventral skin dorsal skin indicating sensitivity melanocytes heavy ions differs dorsal ventral skin taken together results suggest effects low dose heavy ions differ cell types tissues effects prenatal development mice melanocyte development necessarily greater gamma rays
advances database technologies moving attention data managers well known structured relational databases sql like dbs towards nosql approaches especially address big data issues however changing technologies consolidated data management system hard requires great investments deploying hybrid sql nosql approaches could good solution speed transition many domains information systems formal data model design hybrid databases necessary paper presents new data model aimed solving issue starting well known model introduce additional components identify data big data system order drive implementation sql like solutions manage data nosql solutions manage big data paper also discusses hospital information system use case clearly show proposed enriched model successfully adopted
introduction increasing number patients congenital heart disease surviving adulthood also led emergence complications underlying congenital heart disease related surgical interventions associated combordities prevalence particular arrhythmias specific congenital heart disease previously described detailed analysis lesions large number comorbidities previously published methods admissions congenital heart disease identified national inpatient sample associated comorbidities also identified patients univariate analysis done compare risk factors associated specific arrhythmias setting congenital heart disease next regression analysis done identify patient characteristics comorbidities associated increased risk specific arrhythmias results total admissions included analysis congenital heart disease congenital heart disease arrhythmia point common arrhythmia congenital heart disease atrial fibrillation noted arrhythmia followed atrial flutter noted congenital heart disease largest burden arrhythmia found tricuspid atresia prevalence arrhythmia group followed ebstein anomaly arrhythmia prevalence increasing age male gender double outlet right ventricle atrioventricular septal defect heart failure obstructive sleep apnea transposition great arteries congenitally corrected transposition tetralogy fallot frequently noted independent risk factors specific arrhythmias conclusion approximately adult admissions congenital heart disease associated arrhythmia burden arrhythmia varies specific lesion risk factors well understanding help risk stratification help devise strategies lower risk
background meehl regarded schizotypy categorial liability schizophrenia product genes environment gene environment interactions sought test whether schizophrenia related genotypes environmental risk factors predict membership classes defined taxometric analyses positive cognitive perceptual negative interpersonal disorganized schizotypy methods participants completed schizotypal personality questionnaire spq provided information following risk factors cannabis use pregnancy obstetric complications social adjustment family history psychosis saliva samples obtained frequency single nucleotide polymorphism snp alleles associated risk developing schizophrenia could determined genotyped snps mir mmp cnnm ccdc sets spq items subject multiple coherent cut kinetic cck analyses including mean minus cut maximum covariance maximum eigenvalue latent modes analyses results cck analyses indicated latent taxonicity schizotypy across item sets cognitive perceptual class base rate membership predicted snp odds ratio confidence interval adjusted analyses poor social adjustment predicted memberships interpersonal disorganized classes classes found mutually exclusive conclusions schizotypy taxonic schizotypy class membership predicted genetic environmental factors predict schizophrenia findings hold promise complete understanding schizotypy schizophrenia liability state come investigation genes environmental factors associated schizophrenia
paper remesh free deformation method proposed speedup modeling electric motor optimal design process proposed method neither mesh regeneration increase number unknowns required defining boundary mesh well fine computational mesh refined meshes quickly derived using coordinate mapping technique calculation time therefore greatly reduced geometric parameters changed according optimal design time mesh quality guaranteed ensure accurate requirement finite element method numerical examples problems problems reported demonstrate efficiency effectiveness proposed method
objectives investigate relative effectiveness different prompts people dementia multistep tasks home inform prompting technology design methods nine pairs participants one dementia partner relative participated home participants mild moderate dementia aged years functioned planned exploratory levels pool activity level instrument touchscreen computer displayed different prompts two set tasks card envelope player trials scored establish relative effectiveness prompts individual tasks also explored results text audio prompts effective video picture prompts card envelope task seen player task differences may related type actions within tasks card envelope actions easier convey verbally player actions lent visual prompts conclusions designers technology based prompts people dementia consider effectiveness different prompts likely task dependent familiar unambiguous language increase success tailored prompts significant practical challenges associated choosing deconstructing everyday tasks home
aim current study establish prevalence subthreshold body dysmorphic disorder subthreshold bdd community sample adolescents compare disorder correlates individuals subthreshold bdd probable full syndrome bdd probable boo without bdd non bdd self report questionnaires assessing dsm criteria past mental health service use symptoms body dysmorphic disorder anxiety depression obsessive compulsive disorder eating disorders completed australian high school students mean age years male male participants also completed measures assessing quality life muscularity concerns emotional symptoms conduct problems hyperactivity peer problems prevalence subthreshold bdd probable bdd compared non bdd group subthreshold bdd associated elevated symptoms comorbid psychopathology greater past mental health service use male measures poorer quality life elevated muscularity concerns subthreshold bdd participants reported significantly lower mental health service use fewer symptoms depression eating disorders hyperactivity probable bdd participants however comorbid symptoms differ significantly groups findings indicate subthreshold bdd associated substantial difficulties adolescents general community bdd screening include subthreshold presentations may important target early intervention programs
frequency domain approach design digital feedback controls siso systems presented noise gain minimized subject phase margin constraint controller expressed repeated pole expansion reduces optimization quadratic problem linear system equations pid filter controls produced limiting case
background objectives dislocations sprains strains common childhood musculoskeletal injuries requiring medical attention investigated characteristics associated using traditional chinese medicine tcm children suffering injuries methods nationwide representative insurance database taiwan cross sectional study identified children dislocations sprains strains years age newly diagnosed without previous tcm experience children initiated treatment tcm defined tcm users others non tcm group multivariable logistic regression models estimated odds ratios ors tcm use results girls children living central taiwan northern associated higher tcm use adjusted ors confidence interval tcm uses patients years years years compared years group tcm users less likely outpatient visits western medicine care hospitalizations previous year tcm group nearly twice likely non user group receive treatments local clinics conclusions study reveals important demographic medical factors associated tcm uses children dislocations sprains strains interestingly local clinics main healthcare facilities providing tcm services studies needed evaluate outcomes tcm treatment musculoskeletal injuries
objectives unintentional injuries major cause childhood mortality morbidity united states however little epidemiologic information pediatric injuries seen primary care settings objective study characterize types external causes childhood injuries seen primary care physicians compare demographic visit characteristics children injury related visits irvs non irvs methods stratified random sample survey office based practicing physicians national ambulatory medical care survey conducted injury related primary care office visits measured patients million primary care office visits per year rate visits per person years common diagnoses assigned injuries open wounds sprains strains contusions superficial injuries abrasions splinters leading external causes injuries sports overexertion accidental falls natural factors bites stings cutting instruments single common cause pediatric injuries sports overexertion children irvs likely older odds ratio year age confidence interval male reside west rural area less likely asian hispanic visit children irvs likely see physician primary care physician see family physician rather pediatrician conclusions irvs account significant portion primary care children united states identifying potentially preventable external causes injury characteristics children likely injured important injury prevention programs education physicians care children
article investigate swedish consumer prices electricity adjusted equally fast regardless whether nordpool power market prices decreased increased due relatively moderate variations variables applied quantile regression since mainly large changes median essentially tend considerable effect consumer prices moreover order adjust stochastic deterministic trends autocorrelation structural breaks well measure apt effects short medium run apply wavelet decomposition approach results show evidence significantly positive asymmetric price transmission apt effects exist market specifically short run based wavelet decomposition months cycles find higher propensity rapidly systematically increase consumer prices subsequently increase nordpool market price compared propensity decrease customers prices subsequently corresponding drop nordpool market prices however significant apt effects detected medium long run asymmetric price transmission effects observed short run summary could isolate significant apt effects short run months decomposition cycles large changes dependent variable percentiles therefore large changes nordpool prices lead feedback effects form asymmetric price transmission effects evidence supports notion firms downward stickiness retail prices maximizing profit expected found fully efficient market although finding shows price inefficiency short lived large temporal inefficiencies still costly consumers noted blunt traditional powerless methods detect apt effects wavelet quantile methods powerful make significant contribution literature providing new empirical evidence
optimal design electric machines requires significant amount computation time since design usually performed based finite element analysis fea better accuracy reason development optimization algorithm regarded prerequisite reduce number objective function call directly related computation time local search algorithm guarantee global optimum solution searched effectively therefore paper introduce novel optimization method search region management srm improve efficiency local search algorithm srm uses guided random bit generation based gray code region selection local search iterates optimum search process multi start addition srm saves manages information previous searched points prevent overlapping calculation increase effectiveness local search every iteration process clarify effectiveness proposed method electric machine design applied optimal design brushless motor coupled fea minimizing torque ripple
mean platelet volume mpv red cell distribution width rdw neutrophil lymphocyte ratio nlr comprise laboratory markers ankylosing spondylitis controversy literature regarding type ear involvement characteristic aim study simultaneously investigate mpv rdw platelet lymphocyte plr nlr patients relationships high frequency hearing thresholds thirty patients age matched healthy subjects included subject tested low high frequency audiometry additionally case control groups evaluated regarding average hearing thresholds bone conduction erythrocyte sedimentation rate esr reactive protein crp levels measured rdw mpv neutrophils lymphocytes platelet counts evaluated complete blood count furthermore nlr plr calculated complete blood count platelet numbers esr crp nlr levels significantly increased patients compared healthy controls patients increased average measurement values hearing threshold ears frequencies however statistically significant difference average values hearing threshold ears high frequencies significantly increased case group however significantly increased current study first investigate plr nlr mpv rdw levels acute identified significantly increased nlr leukocyte count esr crp patients sensorineural hearing loss especially extended high frequencies common patients may represent extra articular feature disease combined use nlr leukocyte count clinical assessments may facilitate diagnostic process ankylosing spondylitis
aims women basketball increased competitiveness contacts currently experienced players purpose study determine incidence characteristics injuries within elite woman basketball team france order define preventive strategies materials methods prospective study nine months injuries defined obtained according method developed international olympic committee results total incidence injuries exposure exposure training exposure competition athletesexposure lower limbs affected thigh muscle lesions ankle sprains frequent contact injuries frequent fifty one percent injuries caused time loss injuries minor days time loss mean days per injury conclusion epidemiological study used prospective rigorous methodology allow determine preventive strategies injuries focused frequent severe injuries preventive strategies could isokinetic knee flexors extensors evaluation lower limb muscle strengthening lower limbs ankle proprioception elsevier masson sas rights reserved
article constitutes critical reflection gender approach main aspects chilean government program overcoming poverty extreme poverty ethical family income review official documents press releases academic research main objective understand analyze representations gender present social program implications women identified main recipient according analysis made possible see instrumentalization women role mediators public policy families foregoing led reproduction traditional gender roles circumscribes women reproductive domestic role subject rights
study explores perspectives asylum seekers darfur regard four stages journey leaving sudan journey israel living israel future plans group interviews conducted male participants first stage themes included urgent need run life transition family life alone second stage themes included experiencing extreme conditions intense emotions third stage included experiencing positive negative experiences fourth stage included keeping hope alive uncertainty implications social work practice suggested
background testosterone deficiency represents significant health risk factor men importance far underestimated besides physiological age related reduction acquired testosterone deficiency may also occur testosterone deficiency possible result commonly occurring diseases basis development different diseases scope present investigation measurement serum testosterone levels different age groups materials methods serum testosterone levels determined samples healthy men ladr laboratory mvz kramer colleagues geesthacht routine conditions frequency testosterone deficiency calculated different age groups compared using spss software results pathologically low testosterone levels found subjects testosterone level lower decreased testosterone levels associated age addition proportion men decreased serum testosterone levels comparable age groups average serum testosterone level decreased slightly age groups period midday conclusions data reveal high rates testosterone deficiency men independent patient age decreased serum testosterone levels may consequence several diseases causally involved pathogenesis diseases strongly recommended serum testosterone measurement included diagnostic arsenal especially symptoms loss libido erectile dysfunction lack concentration depression lethargy irritability sleep disturbance present
background recent studies identified levonorgestrel administered orally emergency contraception lng efficacious taken ovulation however drug consistently prevent follicular rupture impair sperm function objective present systematic review performed analyze precisely define extent pre fertilization mechanisms action may explain drug efficacy pregnancy avoidance also examine available evidence determine pre ovulatory drug administration may associated post fertilization effects conclusion mechanism action lng reviewed drug ability alter sperm function doses used vivo limited ability suppress ovulation analysis estimates drug ovulatory inhibition potential could prevent less percent potential conceptions thus making pre fertilization mechanism action significantly less likely previously thought luteal effects decreased progesterone altered glycodelin levels shortened luteal phase present literature may suggest pre ovulatory induced post fertilization drug effect lay summary plan widely used emergency contraceptive available important patients physicians clearly understand drug mechanism action moa drug originally thought work preventing fertilization recent research cast doubt review research suggests could act pre fertilization capacity estimate could prevent ovulation percent less cases drug ability alter sperm function limited ability suppress ovulation data suggest administered pre ovulation may post fertilization moa
dynamic performance important consideration long span bridge design owing flexibility low damping various types vibration different sources excitation could occur lifetime long span bridge paper reviews important studies developments long span bridge vibration mechanism control wind seismic traffic human motion excitations types vibration commonly observed long span bridge discussed viewpoint structure engineering discussion subject commenced describing vibration mechanism followed survey observed phenomena many long span bridges associated type vibration paper also describes engineering solutions adopted countermeasures type bridge vibration problem
past four five decades multiple randomized controlled trials verified preventive interventions targeting key parenting skills far reaching effects improving diverse array child outcomes studies shown parenting skills taught malleable given advances prevention scientists position make solid empirically based recommendations public child service systems using parent mediated interventions optimize positive outcomes children families serve child welfare systems serve country vulnerable children families yet slow compared juvenile justice mental health systems adopt empirically based interventions paper describes two child welfare initiated policy based case studies sought scale research based parenting skills routine services caseworkers deliver families serve case studies child welfare system leaders worked evaluators model developers tailor policy administrative fiscal system practices institutionalize sustain evidence based practices usual foster care services descriptions implementations intervention models preliminary results described
background prognostic role hypertension long term survival percutaneous coronary intervention pci limited inconsistent hypothesize hypertension increases long term mortality pci methods analyzed data scaar swedish coronary angiography angioplasty registry consecutive patients admitted coronary care units sweden january may underwent pci due elevation myocardial infarction stemi non elevation myocardial infarction nstemi unstable angina stable angina pectoris used cox proportional hazards regression statistical modelling complete case data well imputed data sets used interaction test evaluate possible effect modulation hypertension risk estimates several pre specified subgroups age categories gender diabetes smoking indication pci stemi nstemi stable angina results study period consecutive patients underwent coronary angiography due stemi nstemi stable angina hypertension median follow years adjustment differences patient characteristics hypertension associated increased risk mortality subgroup analysis risk highest patients less years smokers patients stemi risk lowest patients stable angina interaction test conclusion hypertension associated higher mortality patients stemi nstemi stable angina treated pci
introduction trigeminal neuralgia one disabling facial pain syndromes significant impact patients quality life pharmacotherapy first choice treatment cases drug resistance often require new strategies among various interventional treatments used recent years new therapeutic strategy consisting botulinum toxin emerged promising results development reviewed clinical cases case series open label studies randomized clinical trials examining use botulinum toxin drug refractory trigeminal neuralgia published literature conclusions administration botulinum toxin proven safe effective therapeutic strategy patients drug refractory idiopathic trigeminal neuralgia many questions remain unanswered precise role botulinum toxin treatment disease elsevier espana rights reserved
objective aim study compare outcomes simultaneous delayed implantation kidney grafts combined liver kidney transplantation clkt background data delayed function renal graft dgf result hypotension pressor use related liver transplantation may cause worse outcomes clkt methods total clkts performed indiana university studied observational cohort study kidneys underwent continuous hypothermic pulsatile machine perfusion transplant simultaneous kidney transplantation time group delayed performed later time second operation group patients received continuous veno venous hemodialysis propensity score match analysis case match performed results mean kidney cold ischemia time hours groups hours associated improved kidney function dgf post improved patient graft survival
drawing attention governing role capital accumulation interaction state study examines dynamics new wave suburbanization china characterized development new towns new towns essentially function spatial fix china contemporary accumulation regime rather resulting capital switching primary secondary circuits new towns help collect funds leverage industrial capital thus simultaneously sustain circuits meanwhile development new towns also process territorial development municipal governments expand space accumulation strengthened fiscal land controls develop metropolitan structure underlying specific form dynamics however worldwide trend capital switching declining manufacturing industries developed countries new investment frontier developing countries
introduction estimates adults dementia differ widely distinguish adults living community methods behavioral risk factor surveillance system data households states used cognitive decline module used data respondents adults subjective cognitive decline scd included proxy responses using responses questions receipt informal care scd diagnosed dementia estimates made state results overall range tennessee arkansas noninstitutionalized adults states received informal care scd range tennessee arkansas estimated dementia limiting results respondents reduced estimates significantly discussion combined results respondents nonrespondents representative telephone survey provide varying estimates scd related measures across states highlighting need state specific estimates
rhizome ligusticum chuanxiong effective medical plant extensively applied centuries migraine cardiovascular diseases treatment china polysaccharides plant shown interesting bioactivities previous studies performed neutral polysaccharides study lcp pectic polysaccharide fraction obtained degrees water extracts chuangxiong rhizomes purified diethylaminethyl deae sepharose anion exchange chromatography gel filtration monosaccharide analysis linkage determination addition fourier transform infrared spectrometer nuclear magnetic resonance nmr spectrum indicated lcp typical pectic polysaccharide homo galacturonan rhamnogalacturonan type regions arabinogalactan type type side chains lcp exhibited potent complement fixation activity ich thus potential natural immunomodulator
study sought elucidate associations psychopathy fight flight freeze system fffs behavioral inhibition system bis behavioral approach system bas constructs large offender sample specifically examined whether individual differences systems would mediate relationship psychopathy externalizing behavior used archival data male female adult inmates measurements psychopathy rst constructs externalizing behaviors available path analyses showed fffs bis bas mediated relationship psychopathy externalizing behavior results underscore important role insensitivity punishment plays psychopathy elsevier ltd rights reserved
aim study identify assess evidence related efficacy mind body interventions irritable bowel syndrome ibs chinese population drawn chinese databases nine rcts three studies included systematic review methodological quality rcts evaluated based following criteria adequate sequence generation allocation concealment blinding completeness outcome data selective reporting potential biases continuous variables effect size determined calculating standardized mean difference groups dichotomous variables determined calculating risk ratio groups given heterogeneity trials small number studies included random effects fixed effects models used inverse variance method used pooling statistical analyses performed using review manager version total number papers identified english language databases chinese language databases twelve studies met eligibility criteria among studies selected three studies rest rcts two studies described randomization process none studies reported allocation concealment blinding seven studies reported dropouts one studies mentioned total amount dropouts though reason dropping referenced four studies clearly report dropouts exception three studies inadequate information determine biased reporting majority level risk bias studies unclear finally six meta analyses performed one conducted four randomized controlled trials rcts used cure rate outcome measures evaluate gastrointestinal symptoms suggested mind body interventions effective improving symptoms random effects model fixed effects model remaining five conducted three rcts suggested mind body interventions effective improving several aspects quality life including interference activity random effects fixed effects models smd body image random effects model smd fixed effects model smd health worry random effects fixed effects models smd food avoidance random effects fixed effects models smd social reaction random effects model smd fixed effects model smd measured irritable bowel syndrome quality life questionnaire ibs qol mind body interventions may potential improve symptoms chinese patients ibs improvement symptoms also accompanied improvement various outcomes including depression anxiety quality life mention however published studies generally significant methodological limitations future clinical trials rigorous research design needed field studies focusing mind body interventions originated china tai chi gong encouraged
article presents summary development computer code azkind code based multi group neutron diffusion theory kinetics equations include delayed neutron precursors space discretization galerkin process applied using nodal finite elements method well known method used time discretization high performance computing methodology implemented azkind solve resulting linear algebraic system right arrow right arrow numerical solution large algebraic systems representing full nuclear reactor cores achieved acceleration technique based open source linear algebra paralution library implementation allows azkind threading gpu thousands arithmetic operations parallel processing acceleration demonstrated use different nuclear fuel arrays resulting extremely large matrices getting speedup ratio finally acceleration capabilities hpc implementation presented simulation power transient actual boiling water reactor core elsevier ltd rights reserved
hybrid electric vehicle hev drivetrains electrical generator coupled onto shaft internal combustion engine ice order process either entire given fraction traction power required vehicle wheels ice driven generator confined within vehicle hood exposed heating resulting ice operation high compactness totally enclosed construction suitable machine cooling arrangement become challenging targets generator design must deal due unique characteristics higher torque per volume higher efficiency compared machine topologies axial field permanent magnet machine topology selected min rated generator prototype would utilized demonstrator hev drive train paper describes original solutions adopted design hev generator reports experimental results taken prototype machine
scissor structure used generate deployable objects space saving variety applications architecture aerospace science deployment small regular shape larger one easy design focus challenging task designing planar scissor structure deploys given source shape specific target shape propose two step constructive method generate scissor structure high dimensional parameter space topology construction scissor structure first performed approximate two given shapes well guarantee deployment geometry scissor structure optimized order minimize connection deflections maximize shape approximation optimized parameters deployment simulated controlling anchor scissor unit physical deployable objects fabricated according designed scissor structures using printing manual assembly show number results different shapes demonstrate even fabrication errors designed structures deform fluently source target shapes
solidified materials prepared subjecting powder compacts consisting allophane slaked lime hydrothermal reaction various temperatures hydrogarnet formed hydrothermal reaction reaction allophane slaked lime bending strength materials solidified hydrothermal reaction degrees greater mpa improvement strength materials hydrothermal reaction degrees due formation fine deposits surface allophane aggregates deposits filled spaces particles starting materials hydrothermal reaction temperatures greater degrees resulted collapse allophane structure leading decrease strength materials elsevier rights reserved
youth sports participation rise resulting increase sports related injuries pediatric adolescent population presentation injury pathology disease younger population often unique may require customize novel medical rehabilitation interventions optimize outcome purpose review highlight unique considerations rehabilitation management pediatric adolescent athlete general guidelines progression population criteria based rehabilitation program focus systematic return sport algorithm reviewed
work wrf meteorological model run three different modes estimate wind energy potential bay biscay period first simulation noda involves typical use wrf model use data assimilation second one hda performs dvar data assimilation utc utc finally hda uses dvar data assimilation utc utc utc utc verification three simulations carried preliminary stage using wind data buoys spatially distributed analysis conducted surface wind based satellite data cross calibrated multi platform ccmp purpose spatial correlation error patterns study area used statistical indicators results indicate wind values obtained data assimilation every six hours hda yield best verification scores confidence level thereby accurate reproducing wind observations area regarding estimation wind energy potential second stage tested calculation sensitivity use data assimilation reliable simulation data assimilation hda estimates less energy potential simulation without data assimilation absence historical wind observation records sea sufficient time space resolution meteorological models wrf provide estimation wind values tentative areas offshore wind farms line study highlights need use meteorological models data assimilation future wind energy production realistically estimated beforehand may also contribute accurate economic technical evaluation risks benefits future investments offshore wind energy elsevier ltd rights reserved
embedded class processors found commodity palmtop computers continue become increasingly capable moreover wireless connectivity systems provides new opportunities designing flexible smarter wireless sensor networks wsns paper present lynx self organizing wireless sensor network framework leveraging palmtop systems sensor hubs lynx provides fundamental functionality make distributively managed customizable wsn system implementation second describe ocelot mobile distributed grid like computing engine commodity palmtop platforms combination lynx ocelot provides sensor nodes capable collecting recording processing communicating data without central server support significant energy savings achieved light medium weight tasks lynx ocelot combined system compared traditional server class grid solutions boinc demonstrate lynx ocelot context life cycle building energy usage elsevier ltd rights reserved
across united states child abuse law governed state statute pediatricians must report suspected child abuse neglect accordance state specific reporting requirements failure make timely report creates civil liability exposures triggers criminal penalties pediatrician initial report may instigate investigation child protective services reporting pediatrician may later become involved critical fact witness ensuing legal proceedings including criminal prosecutions custody determinations medical malpractice controversies reporting pediatrician testimony may influence disposition matters significantly affect well involved children dutifully reporting pediatricians promulgate engage peerless child advocacy
background dietary plant based foods contain combinations various bioactive compounds phytochemical compounds vitamins combined effect vitamins phytochemicals remains unknown especially prevention diabetes complications present study aimed investigate combined effect ascorbic acid gallic acid fructose induced protein glycation oxidation results ascorbic acid gallic acid reduced fructose induced formation advanced glycation end products ages bovine serum albumin bsa respectively combination ascorbic acid gallic acid demonstrated additive inhibition formation ages weeks incubation addition synergistic inhibition formation amyloid cross beta structure protein carbonyl content fructose glycated bsa observed concentration combination ascorbic acid gallic acid produced significant additive effect diphenyl picrylhydrazyl radical scavenging activity conclusion combining natural compounds ascorbic acid gallic acid seems promising strategy prevent formation ages pontificia universidad catolica valparaiso production hosting elsevier rights reserved
human adults automatically mimic others emotional expressions believed contribute sharing emotions others although behaviour appears fundamental social reciprocity little known developmental process therefore examined whether infants show automatic facial mimicry response others emotional expressions facial electromyographic activity corrugator supercilii brow zygomaticus major cheek four five month old infants measured viewed dynamic clips presenting audiovisual visual auditory emotions audiovisual bimodal emotion stimuli display laughing crying facial expression emotionally congruent vocalization whereas visual auditory unimodal emotion stimuli displayed emotional faces vocalizations paired neutral vocalization face respectively increased activation corrugator supercilii muscle response audiovisual cries zygomaticus major response audiovisual laughter observed stimulus onset clearly suggests rapid facial mimicry contrast visual auditory unimodal emotion stimuli activate infants corresponding muscles results revealed automatic facial mimicry present early five months age multimodal emotional information present
background electrocardiographically measured interval heritable prolongation established risk factor several cardiovascular diseases yet genetic studies performed european ancestral populations possibly reducing global relevance objective leverage diversity improve biological insight fine mapped previously identified loci populations african american hispanic latino ancestry methods racial ethnic specific multiple linear regression analyses adjusted heart rate clinical covariates examined separately combination inverse variance weighted trans ethnic meta analysis results fine mapped qtlociincludedontheillumina metabochip represented independent signals significantly value finally bioinformatics based functional characterization suggested regulatory function cardiac tissues majority independent signals generalized novel snps conclusion findings suggest majority identified snps implicate gene regulatory dysfunction prolongation loci influence variation across global populations additional novel population specific signals exist
precipitation still one complex climate variables observe understand handle within climate monitoring climate analysis well simulate numerical weather prediction climate models especially ocean less known precipitation land due sparsity situ observations introduce discuss global expert team climate change indices etccdi based precipitation climatology basis computation climatology global precipitation dataset daily precipitation analysis climate prediction dapaclip combines situ observation data land satellite based remote sensing data ocean daily temporal resolution namely data global precipitation climatology centre gpcc hamburg ocean atmosphere parameters fluxes satellite data hoaps dataset dapaclip dataset spans period thus global etccdi based precipitation climatology covers years total regional aspects climatology also discussed focus europe monsoon region south east asia knowledge first presentation discussion etccdi based precipitation climatology global scale
objective emergency contraception accessibility evolved differently catalunya compared autonomous communities spain free charge access within public health system authorised counter otc access implemented aim study assess impact measures demand users profiles institution methods retrospective study emergency department conducted evaluate requests relationship accessibility modifications age women days week attended analysed results number requests distribution age demand week remained stable access became free charge however requests sharply decreased following otc access implementation distribution age also changed significant increase requests women years demand greatest sunday monday distribution persisted study period conclusion requests remained unchanged following free charge access decreased otc implementation women currently seeking cost institution likely younger request monday
paper twofold inverse problem orthogonal matrix functions wiener class considered scalar valued version problem solved ellis gohberg reasonable conditions problem reduced invertibility condition operator defined using hankel toeplitz operators associated wiener class functions comprise data set inverse problem also shown case solution unique special attention given case hankel operator solution strict contraction case functions matrix polynomials elsevier inc rights reserved
bacterial nanocellulose bnc emerging nanomaterial morphologic structure network unique properties produced several species bacteria objective present work evaluate whether addition bnc improved baking quality wheat flours making change viscoelastic behavior mass study rheological behavior wheat bread dough containing bnc performed thermo rheological isothermal dynamic oscillatory experiments baking response bread quality parameters also analyzed bnc increased specific volume moisture retention decreasing browning index although bnc produced raw heat treated doughs elastic characteristics textural studies revealed addition bnc reduced firmness bread crumb confocal laser scanning microscopy observations showed differences gluten filaments control bnc crumb samples could explain larger average porous size bnc crumb bnc could used improver bread making performance elsevier ltd rights reserved
order competitive software industry essential adopt standards reference models software processes quality however despite growing adoption standards models number organizations adopt small portion total population software organizations paper presents tool support implementation decision analysis resolution process adherence cmmi dev model tool aims assist software organizations implementation cmmi dev model expect tool easily adopted software organizations based models standards largely accepted furthermore tool adopts free technologies non proprietary order reduce costs
provide integrative review basic control circuits introduce techniques regulation quantitatively measured using human neuroimaging illustrate utility control systems approach using four human neuroimaging threat detection studies applied circuit wide analyses order identify key mechanism underlying individual variation build upon canonical prefrontal limbic control system integrate circuit wide influence inferior frontal gyrus ifg incorporated computational control systems model constrained neuroanatomy designed replicate experimental data model ifg acts informational set point gating signals primary prefrontal limbic negative feedback loop cortical information gathering loop along cortical route sensory cortex provides sufficient information make threat assessment signal passes ventromedial prefrontal cortex vmpfc whose threat detection threshold subsequently modulates amygdala outputs however signal outputs sensory cortex provide sufficient information first pass signal loops back sensory cortex cycle providing increasingly fine grained processing sensory data simulations replicate ifg chaotic dynamics experimentally observed ends threat detection spectrum identify distinct types ifg disconnection circuit associated clinical outcomes ifg thresholds high ifg sensory cortex cycle long meantime coarse grained excitatory pathway dominate biasing ambiguous stimuli false positives hand cortical ifg thresholds low inhibitory pathway suppress amygdala without cycling back sensory cortex much needed fine grained sensory cortical data biasing ambiguous stimuli false negatives thus control systems model provides consistent mechanism ifg regulation capable producing results consistent data full spectrum threat detection fearful optimal reckless generally illustrates quantitative characterization circuit dynamics used unify fundamental dimension across psychiatric affective symptoms
study question first trimester phthalate exposure associated anogenital distance agd biomarker prenatal androgen exposure newborns summary answer concentrations diethylhexyl phthalate dehp metabolites first trimester maternal urine samples inversely associated agd male female newborns known already agd sexually dimorphic measure reflecting prenatal androgen exposure prenatal phthalate exposure associated shorter male agd multiple animal studies prior human studies limited small sample size imprecise timing exposure outcome reported conflicting results study design size duration infant development environment study tides prospective cohort study pregnant women recruited prenatal clinics san francisco minneapolis rochester seattle participants delivered infants complete data included analysis participants materials setting methods woman years old able read write english spanish weeks pregnant whose pregnancy medically threatened planned deliver study hospital eligible participate analyses include infants whose mothers provided first trimester urine sample examined shortly birth specific gravity spg adjusted concentrations phthalate metabolites first trimester urine samples examined relation genital measurements boys obtained two measures anogenital distance agd anoscrotal distance agd anopenile distance agd well penile width girls measured anofourchette distance agd anoclitoral distance agd used multivariable regression models adjusted infant age exam gestational age weight length score time day urine collection maternal age study center main results role chance three metabolites dehp significantly inversely associated measures boys agd associations beta confidence interval agd log spg adjusted phthalate concentrations mono ethylhexyl phthalate mehp mono ethyl oxohexyl phthalate meohp mono ethyl hydroxyhexyl mehhp associations similar magnitude agd associations weaker statistically significant phthalate metabolites associated genital measurement boys nophthalate metabolites associated either agd measure girls limitations reasons caution exposure assessment based single first trimester urine sample may introduced exposure misclassification addition significant center differences suggest measurement difficult standardize wider implications findings findings consistent multiple rodent studies human studies far smaller data report suggest even current low levels environmental exposure dehp adversely affect male genital development resulting reproductive tract changes may impact reproductive health later life findings important implications public policy since pregnant women exposed ubiquitous chemical
comparison performance four full scale aerated horizontal flow constructed wetlands conducted determine efficacy technology sites receiving high variable ammonia loading rates yet reported literature performance assessed terms ammonia solids removal hydraulic conductivity mixing patterns capability systems produce ammonium effluent concentrations mgnh observed across sites systems receiving variable loadings gnh potential resilience issues observed relation response spike loadings posited due insufficient nitrifying population within beds hydraulic conductivity flow mixing patterns observed suggested deterioration reactor effective volume time overall study demonstrates efficacy technology ammonium removal required small sites receiving high variable flow rates adequate removal organics solids significant benefit long term hydraulics system
occurrence osteoporosis tuberculosis chronic infection rarely evaluated study found significantly higher incidence rates osteoporosis adjusted hazard ratio ahr osteoporotic fracture ahr tuberculosis patients matched cohorts suggest osteoporosis screening considered tuberculosis patients follow program aim study determine occurrence incident osteoporosis patients completed anti tuberculosis treatment chronic inflammatory disorders associated increased risk osteoporosis although infectious disease characterized systemic inflammatory responses impact active incident osteoporosis unclear used taiwan national health insurance research database investigate association history active incident osteoporosis osteoporotic fracture nationwide retrospective cohort study active patients age sex matched controls identified national health insurance research database taiwan occurrence incident osteoporosis osteoporotic fractures risk factors associated osteoporosis among patients matched controls analyzed observed incident osteoporosis patients matched controls incidence rate osteoporosis per person years significantly higher patients multivariate analysis independent risk factor osteoporosis independent factors associated osteoporosis older age female sex chronic obstructive pulmonary disease asthma lower income moreover demonstrated occurrence osteoporotic fracture significantly higher patients patients history active higher incidence rate osteoporosis osteoporotic fracture
background sensitive skin widespread condition frequently reported women changing hormone levels menstrual cycle menopause suggested among stimuli triggering sensitive skin objectives investigate perceived influence fluctuating hormone levels self assessed sensitive skin including symptoms stimuli linked skin sensitivity well potential changes facial body skin sensitive body parts depending hormonal status patients methods digital questionnaire distributed population women aged years old results total women included analysis premenopausal women declared perception increased skin sensitivity menstrual cycle reported almost peri postmenopausal women following menopause majority reported symptoms included presence bumps pimples dryness itching redness majority reported stimuli shaving weather toiletries emotions differences emerged regarding characteristics facial body skin across different hormonal status significant differences sensitivity body parts emerged face feet reported larger percentage premenopausalwomen peri postmenopausalwomen respectively conclusion prevalence perceived effects fluctuating hormone levels self assessed sensitive skin women high effects taken consideration skin testing dermatological practice support need selecting personal care routine treatment menstrual cycle menopause
paper addresses nonlinear inverse source problem identifying multiple unknown time dependent point sources occurring evolution advection diffusion reaction equation prove time records associated state taken upstream downstream involved source positions uniquely identify unknown elements defining sought time dependent point sources number bigger equal based impulse response techniques establish identifiability theorem reasonable assumptions time state recording positions yields uniqueness unknown elements theorem together data assimilation result led develop source detection identification method goes throughout monitored domain detect presence unknown active source occurring two state recording points source detected established identification procedure localizes position determines total amount loaded source identifies historic time dependent source intensity function numerical experiments variant surface water biological oxygen demand pollution model presented
rheumatoid patients injuries treated orthopaedic rheumatologists well trauma surgeons surgeons must take account numerous factors influence treatment special patient population immunosuppressive drugs severe osteoporosis atrophy skin subcutaneous fat muscles joint instability arteriosclerosis requires knowledge immunology pharmacology entire spectrum internal medicine well special care treatment vulnerable tissues polytrauma patients inflammatory diseases rheuma toid serositis may misinterpreted lethal outcome high lethality vertebral fractures related ankylosing spondylitis treated carefully instability cervical spine especially atlantooccipital atlantoaxial joints common long standing rheumatoid arthritis manipulation cervical spine may lead cervical cord injury respiratory arrest
idiopathic pulmonary fibrosis ipf fatal progressive lung disease occurring adults last decade results number clinical trials based updated disease classification published registration pirfenidone nintedanib first two pharmacological treatment options approved ipf marks new chapter management patients disease nonpharmacological treatments lung transplantation rehabilitation palliation also shown beneficial patients review past present management discussed based comprehensive literature search treatment algorithm presented based available evidence overall clinical experience addition unmet needs regard treatment highlighted discussed describe development various treatment options ipf first consensus recent guidelines based evidence large scale multinational randomized clinical trials led registration first drugs ipf
paper presents chopper amplifier precision current sensing capable handling common mode input voltages outside supply rails high common mode rejection ratio cmrr gain amplifier employs three stage topology nested miller frequency compensation using chopping technique referred input offset voltage obtained reduce output ripples caused chopping technique amplifier employs notch filter cmrr obtained considering supply voltage common mode input voltage range stability operational amplifier ensured minimum closed loop gain
paper reports research developing cyberinfrastructure platform support multivariate visualization data collected distributed sensor network three new techniques introduced platform hybrid data caching strategy takes advantages scalable distributed time series database opentsdb realize efficient data retrieval hyper dimensional data cube established map translate multivariate heterogeneous sensor data common data structure support location aware visual analysis data driven visualization module implemented support interactive dynamic visualization simulated virtual globe series experiments conducted demonstrate good runtime performance proposed system expect work make major contribution visualization building block development cyberinfrastructure research advancement visual presentation analysis sensor data domain sciences
ill posed inverse problems call prior model define suitable set solutions wide family approaches relies use sparse representations dictionary learning precisely permits learn redundant set atoms represent data sparse manner various approaches proposed mostly based optimization methods propose bayesian non parametric approach called ibp uses indian buffet process prior method yields efficient dictionary adaptive number atoms moreover noise sparsity levels also inferred parameter tuning needed elaborate ibp model propose model linear inverse problems inpainting compressive sensing beyond basic denoising derive collapsed accelerated gibbs samplers propose marginal maximum posteriori estimator dictionary several image processing experiments presented compared approaches illustration elsevier inc rights reserved
paper presents novel implementation gpu computing boundary element method bem formulation plates new gpu code written cuda fortran alters three kernels calculation influence matrices solution equations computation internal values comparisons computation time different gpu architecture presented formulation implemented constant quadratic elements efficiency parallel quadratic code demonstrated via analysis practical building slabs benefits parallel computing solution system equations points inside domain discussed
study novel multi band metamaterial absorber proposed ultra thin compact polarisation insensitive wide angle absorptive proposed structure comprises two concentric metallic rings printed dielectric substrate backed metal ground plane proposed structure exhibits four distinct absorption peaks ghz peak absorptivities respectively normal incidence designed absorber polarisation insensitive due four fold symmetry confirmed simulation measurement studies moreover structure shows high absorption oblique incident angles degrees transverse electric transverse magnetic polarisations surface current distributions four absorption frequencies illustrated explain absorption mechanism structure addition several parametric variations performed observe effects geometrical dimensions absorption performance free space measurement method utilised measure responses fabricated structure good agreement simulated results proposed ultra thin approximate thin corresponding lowest absorption frequency absorber anticipated useful various potential applications like stealth technology electromagnetic interference electromagnetic compatibility wireless communication
nuclear thermal rocket ntr propulsion viable meritorious option human exploration deep space high thrust improved specific impulse well established technology bimodal capability enhanced mission safety reliability ntr technology already investigated tested united states america russia former soviet union representative nuclear engine rocket vehicle applications nerva type reactors traditionally used highly enriched uranium heu fuels shaped hexagonal fuel element geometries importance making high power reactor minimum size although heu ntr designs best choice terms rocket performance technical maturity inevitably provoke nuclear proliferation obstacles research development activities civilians non nuclear weapon states also potential commercialization overcome security issues due heu non proliferative small size ntr engine low thrust levels klb similar klb korea advanced nuclear thermal engine rocket utilizing low enriched uranium fuel kanuter leu designed future generations design goals make use leu fuel fairly compact core minimize rocket performance sacrifice relative traditional heu ntrs achieve goals new space propulsion reactor conceptually designed key concepts high uranium density fuel resistance high heating corrosion thermal neutron spectrum core compact integrated fuel element core design protective cooling capability addition preliminary design study neutronics thermal hydraulics performed explore design space new leu ntr reactor concept result indicates innovative reactor concept great potential implement use leu fuel create comparable rocket performance compared existing heu ntr designs elsevier ltd rights reserved
background individuals criminal justice system demonstrate high rates cigarette use low adherence smoking cessation medication educational approaches shown promote adherence cessation though medication sampling boosted use cessation objective present study determine whether vivo nicotine replacement therapy nrt sampling approach increases nrt adherence among criminal justice smokers subsequent quit attempt methods conducted pilot study community corrections smokers randomized session one min session per week precessation intervention either vivo nrt sampling session patch session gum session combination nrt cnrt session review time matched sessions standard smoking cessation cnrt started session groups received additional weeks cnrt following four intervention sessions results vivo administration nrt total withdrawal craving severity significantly decreased pre post session compared control participants vivo participants evinced greater patch use session greater gum use week relative controls discussion vivo nrt sampling may increase nrt adherence relative standard counseling sessions among criminal justice smokers larger trial novel intervention appears warranted elsevier ltd rights reserved
climate change altering timing duration vernal window period marks end winter start growing season rapid transitions ecosystem energy water nutrient carbon dynamics take place research period typically captures portion ecosystem transition focuses largely dates system wakes previous work addressed lags transitions represent delays energy water nutrient carbon flows objectives study establish sequence physical biogeochemical transitions lags vernal window period understand climate change may alter synthesized observations statewide sensor network new hampshire usa concurrently monitored climate snow soils streams three year period supplemented observations climate reanalysis data snow data assimilation model output satellite spectral data found transitions occurred within vernal window sequential air temperatures warming prior snow melt preceded forest canopy closure transitions simultaneous one another zero length lags snowpack disappearance rapid soil warming peak stream discharge modeled lags function winter coldness snow depth expected decline climate change warmer winters less snow resulted longer lags protracted vernal window lengthening individual lags entire vernal window carries important consequences thermodynamics biogeochemistry ecosystems winter spring transition throughout rest year
current approaches computer vision based expensive high performance hardware meet heavy computational requirements employed algorithms system architectures severely limited practical application due financial technical limitations work different strategy used namely development inexpensive easy deploy computer vision system motion detection achieved three means first affordable flexible hardware platform employed secondly motion detection algorithm specifically tailored involve small computational load thirdly fixed point programming paradigm followed implementing system reduce computational requirements proposed system experimentally compared standard motion detector wide range benchmark videos reported results indicate proposal attains substantially better performance remains affordable easy install practice elsevier ltd rights reserved
background dickkopf dkk soluble inhibitor canonical wnt pathway plays critical roles embryonic development evidence suggests molecule regulates several aspects bone biology fibrosis objectives provide overview current knowledge role dkk joint remodeling fibrosis methods performed electronic search medline using following key words dickkopf dkk new bone formation joint remodeling ankylosing spondylitis systemic sclerosis scleroderma fibrosis supplemented manual search references retrieved articles results dkk master regulator joint remodeling animal models arthritis shifting balance toward new bone formation expression decreased toward erosion joint destruction expression increased humans evidence suggests dkk may dysfunctional patients ankylosing spondylitis prototype bone forming disease moreover data animal models indicate dkk protective role fibrosis several organs recent data suggest inhibiting canonical wnt pathway overexpression dkk could way target tgf beta signaling fibrotic diseases finally cell depletion therapy systemic sclerosis may exert effects tgf beta dependent upregulation dkk conclusions dkk appears play crucial role joint remodeling ectopic ossification fibrosis may prospective therapeutic modality fibrotic diseases diseases characterized pathologic joint remodeling elsevier inc rights reserved
correlational descriptive study aimed validate predictive model risk developing eating behavior disorder young people based measurement variables eating behavior body image dissatisfaction body mass index family functioning use criticism toward young people weight shape body young people parents non randomized sample convenience included participants adolescents aged years studying different high schools family members considered significant teenagers eat eca family apgar feics bmi applied validated colombian population result multivariate analysis found high risk developing behavioral disorders young people related high risk relatives article concludes parents addition playing protective role may represent risk factor eating behavior children given children model behavior parents early childhood
beta glucans activate innate immune responses major component cell wall cyst form pneumocystis current study examined whether beta glucans masked surface proteins pneumocystis role beta glucans play pneumocystis associated inflammation species including pneumocystis jirovecii causes pneumocystis pneumonia humans pneumocystis carinii pneumocystis murina beta glucans masked organisms demonstrated increased exposure following trypsin treatment using quantitative polymerase chain reaction microarray techniques demonstrated mouse model pneumocystis pneumonia treatment caspofungin inhibitor beta glucan synthesis days decreased expression broad panel inflammatory markers including interferon gamma tumor necrosis factor alpha interleukin beta interleukin multiple chemokines chemokine ligands thus beta glucans pneumocystis cysts largely masked likely decreases innate immune activation mechanism presumably developed interactions immunocompetent hosts organism loads substantially lower immunosuppressed hosts high organism burden organism death release glucans appears important contributor deleterious host inflammatory responses
clinical preclinical studies cardiovascular calcification often require interpretation images histopathology computed tomography intravascular ultrasound positron emission tomography avoid potential pitfalls biological inferences investigators know happens data image processing algorithms limitations cross sectional images studying mechanostability smoothing algorithms mask partial volume artifacts positron emission tomography
current trends manufacturing engineering activities show direction spreading system level multiple system level design instance product level optimality optimality portfolio products one sme network cooperating smes etc objective current study analyze product lifecycle quotation generation processes different enterprises well find weaknesses strengths different processes created concept web based module collecting client data requests enabling classify product bom manufacturing route finally allows calculation product optimal price levels making automatic offers web proposed module increases cooperative enterprises effectiveness sales volumes profitability
children motor coordination problems exhibit impairments gross motor eye body coordination exergames good supporting motor therapeutic interventions however available exergames designed support needs children presenting excessive cognitive load suggesting practice inappropriate body interactions work investigate design exergames support children motor problems gross motor therapeutic interventions followed iterative user centered design methodology design froggybobby exergame support children motor problems practicing eye body coordination exercises design involved two qualitative studies study understand problem space study validate initial design froggybobby additionally held participatory design sessions uncover gameful mechanisms appropriate motor coordination exercises support motor therapeutic interventions evaluate froggybobby conducted deployment study children low functioning autism presenting motor problems psychologist teachers school clinic autism froggybobby found easy use fun engaging children autism teachers psychologist teachers perceived froggy bobby impacted motor functioning socialization body awareness successfully supported motor therapeutic interventions close reflecting results present new insights design technical therapeutic point view elsevier ltd rights reserved
recruitment monocytes endothelial cells important early stages atherosclerosis development activated response number inflammatory stimuli including oxidized low density lipoprotein ldl montelukast licensed drug approved food drug administration fda clinically used treatment asthma reducing eosinophilic inflammation airway little information regarding effects montelukast endothelial inflammation reported current study found montelukast markedly reduced ldl induced monocyte adhesion human umbilical vein endothelial cells addition inhibitory mechanism montelukast associated suppression adhesion molecule expression including vcam selectin mechanistically erk mediated expression transcriptional factor klf found involved anti inflammation effects montelukast ldl induced endothelial inflammation results indicate montelukast plays protective role early stages atherosclerosis elsevier inc rights reserved
introduction crisaborole topical ointment anti inflammatory non steroidal phosphodiesterase inhibitor currently investigation potential role treatment atopic dermatitis psoriasis areas covered far trials completed atopic dermatitis strength appeared superior dosing regimen pruritus improved significantly within one week improvements objective efficacy assessments crisaborole treated patients also statistically significant compared vehicle expert commentary crisaborole several key features mode action distinguish existing treatments atopic dermatitis notably activity phosphodiesterase pde pathway regulating cyclic amp camp levels less immunosuppressive pathways effect skin thinning pathway interrupts itch sensation pruritus means itch scratch cycle bane life patients interrupted usually early days treatment hence promising safety profile demonstrated early treatment mild moderate patients might help control better improve quality life patients
background human dopamine receptor gene three polymorphic variants alter amino acid sequence alanine substitution valine position proline substitution serine position serine substitution cysteine position functional role never object extensive studies even though evidence occurrence correlates schizophrenia methods hek cell line transfected dopamine receptors genetic variants receptor coupled fluorescent proteins allowed measure extent dimerization receptors using highly advanced biophysical approach flim fret additionally fluoro used examine changes level calcium release ligand stimulation cells expressing different combinations dopamine receptors results using flim fret experiments shown hek expressing dopamine receptors polymorphic mutations receptor play role dimmer formation dopamine receptor association level dopamine receptors affected ligand administration variable effects depending polymorphic variant dopamine receptor found level heteromer formation reflected calcium ion release ligand stimulation observed variations effect dependent polymorphic variant ligand conclusion data presented paper support hypothesis role calcium signaling regulated heteromer may relevance schizophrenia etiology institute pharmacology polish academy sciences published elsevier rights reserved
background chronic insomnia major public health problem affecting approximately adults use meditation yoga develop mindful awareness mindfulness training may effective approach treat chronic insomnia sleep outcomes comparable nightly use prescription sedatives durable minimal side effects purpose study understand mindfulness training experienced patients chronic insomnia suggest procedures may useful optimizing sleep benefits methods adults completed week mindfulness based stress reduction mbsr program part randomized controlled clinical trial evaluate mbsr treatment chronic insomnia invited participate post trial focus groups two groups held participants described sleep routine thoughts emotions affected mbsr utility various mindfulness techniques groups audio recorded transcribed analyzed using content analysis results four themes identified impact mindfulness sleep motivation adopt healthy sleep lifestyle benefits mindfulness aspects life beyond sleep challenges successes adopting mindfulness based practices importance group sharing support participants said sleeping sleeping better waking refreshed feeling less distressed insomnia better able cope occurred participants experienced course call action practicing meditation following sleep hygiene guidelines became priorities motivation sustain behavioral changes reinforced feeling physically better emotionally stable seeing others mbsr class improve body scan identified effective tool enable falling asleep faster participants described needing continue practicing mindfulness maintain benefits conclusions first person accounts consistent published trial results positive impacts mbsr sleep measured sleep diary actigraphy self report sleep scales findings indicate mindfulness training group format combined sleep hygiene education important effective application mbsr treatment chronic insomnia
efficacy rabbit antithymocyte globulin atg prevention graft versus host disease gvhd evaluated several randomized control trials results show discrepancies therefore performed systematic review meta analysis covering latest rcts including six trials total patients incidence acute chronic gvhd significantly lower atg arms risk ratio respectively significant differences found regarding overall survival incidence relapse non relapse mortality however incidence cytomegalovirus epstein barr virus reactivation increased risk ratio neutrophil engraftment significantly delayed median days conclusion rabbit atg beneficial gvhd prophylaxis addition conventional regimens close monitoring virus reactivation enough attention delayed engraftment studies comparing timing dosage atg essential determine suitable prophylactic regimens
background hiv associated neurocognitive disorder hand remains common despite antiretroviral therapy art hiv dysregulates iron metabolism cerebrospinal fluid csf levels iron iron transport proteins hiv infected hiv persons largely unknown objectives study characterize csf iron related biomarkers hiv adults explore relationships known predictors hand methods quantified total iron transferrin heavy chain ferritin immunoassay csf sampled lumbar puncture hiv participants multi center observational study evaluated biomarker associations demographic hiv related correlates hand age sex self reported race ethnicity art detectable plasma virus csf viral load multivariable regression subset existing csf serum albumin alb measurements alb comorbidity severity also included covariates account variability blood csf barrier results among individuals median age years women non whites median nadir cell count cells undetectable plasma virus men higher csf transferrin median higher ferritin median women rho values csf iron higher self reported hispanics higher non hispanic whites non hispanic blacks median hispanics whites respectively blacks findings persisted adjustment age sex hiv specific factors median ferritin higher years younger persons age years findings lost statistical significance subset analyses adjusted alb comorbidity additional adjustments associations observed csf iron transferrin race ethnicity well csf transferrin sex art ferritin plasma virus detectability significant comorbidity conclusions csf iron biomarkers associated demographic factors art csf hiv adults future studies investigate role cns iron dysregulation altered blood csf barrier may contribute hand
background growing evidence interaction hiv infection anti retroviral therapy art cardiovascular diseases cvd epidemiological studies europe north america observing shift towards increased incidence coronary heart disease acute myocardial infarctions hiv infected populations compared general population even adjusting traditional cardiovascular risk factors despite south africa sub saharan africa ssa regarded epicentre global hiv epidemic little known prevalence cardiovascular risk factors precursors vascular disease hiv infected populations region knowledge gap widened paucity data prospective studies present rationale objectives key methodological features endoafrica study aims determine whether hiv infection art associated altered cardiovascular risk changes vascular endothelial structure function adults living western cape province south africa methods longitudinal study comprehensive cardiovascular assessments hiv negative hiv positive without art study participants performed clinical biochemical screening traditional cardiovascular risk factors biomarkers cvd vascular endothelial function determined brachial artery flow mediated dilatation fmd carotid intima thickness imt measurements quantitative retinal blood vessel analyses complemented vascular endothelial biomarker assays finally aim statistically determine whether hiv infection art associated increased cardiovascular risk vascular endothelial dysfunction determine whether progression regression endpoints months baseline assessments discussion endoafrica study provides unique opportunity recruit cohort hiv infected patients hiv negative controls comprehensively longitudinally assessed cardiovascular risk disease profile vascular endothelial function potentially important intermediate cardiovascular phenotype knowledge first time systematic study established context ssa south africa
nitinol niti shapememory alloysare proposed recuperative sports injuries round wires electrical properties investigated order characterize active elements constructive solutions presented response time andrate smart materials analysed response smart material different activation parameters included electromyography results human muscles nicesolutions usage thermal water applications corrosion resistance ofnitinol wires determinedusing potentiostat equipment surface state evaluated byscanning electronmicroscopy sem detector images affected area pitting corrosion type modifies metallic material surface causing loss nickel element determined using anenergy dispersive ray analyseredax deterioration loss shapememory effect influence ofcorrosion shapememory effect evaluated using differential scanning calorimeter dsc observed following transformation temperatures critical point modification modification martensite austenite transformation characteristics
reproduction essential survival species influenced external factors smoking exposure chemotherapy well chronic disorders obesity autoimmunity reproductive senescence menopause also dependent onmultiple intrinsic genetic factors reproductive aging isolated overall aging process several studies strongly support link early age menopause mortality extreme form reproductive aging primary ovarian insufficiency poi prevalence ranging female population poi shown long termconsequences overall health poi age menopause significant hereditary component population based genome wide association studies identified genomic loci associate age menopause loci harbor dna damage response genes recent application whole exome sequencing carefully selected families poi also revealed significant contribution dna damage response genes inability repair dna damage somatic germ cells might predisposing factor link reproductive overall aging subset individuals poi aim review characterize recent advances genetics poi link overall health
high frequency surface wave radar hfswr vital civilian military significance continuous maritime surveillance activities within exclusive economic zone however hfswr lower spatial temporal resolutions received signals strongly polluted different clutter background noise therefore ship target detection hfswr become challenging task letter presents automatic ship target detection algorithm based discrete wavelet transform dwt first peak signal noise ratio based algorithm proposed automatically determine optimal scale dwt extraction ship targets second high frequency coefficients dwt optimal scale processed fuzzy set based method enhance useful target information depress unwanted background noises third target highlighted image reconstructed ignoring low frequency coefficients performing inverse dwt enhanced high frequency coefficients finally targets extracted adaptive threshold segmentation final target highlighted image experimental results show proposed approach automatically extract ship targets effectively range doppler images complex background better target detection performance previous wavelet based algorithm thereby providing new reliable image processing based method ship target detection hfswr
purpose sexual orientation affects individuals health histories fundamental providers understanding patients whole gay bisexual men sex men msm vulnerable certain health conditions including hiv aim exploratory analysis examine factors associated sexual orientation disclosure communication providers msm health issues discuss implications methods conducted cross sectional internet survey msm london middlesex ontario canada analyses limited regular primary care provider blockwise regression models explored demographic psychosocial healthcare related factors associated sexual orientation disclosure physician patient communication msm related health results seventy one percent participants reported primary care provider pcp knew sexual orientation talked msm health overt negative comments refused care based sexual orientation occurred infrequently although reported provider assumed heterosexual married living common law another man frequent experiences homosexual prejudice higher quality assessment provider communication skills associated pcp knowing respondents sexual orientation greater internalized homonegativity associated talking pcp msm related health issues frequent experiences homosexual prejudice higher assessment provider communication prior negative experiences pcp significantly associated talking pcp msm health conclusion majority sample disclosed sexual orientation however patients voluntarily disclose medical training education canada specific rights protections exist sexual orientation minority populations emphasize awareness essential patient health information training include information msm health building foundation speak msm patients nonjudgmentally
paper enhanced genetic algorithm ega based proportional integral derivative pid controller presented control nonlinear dynamic process ega crossover elite offspring optimized using ant colony optimization aco improves convergence characteristics optimization capabilities traditional genetic algorithm proposed algorithm implemented closed loop control continuous stirred tank reactor cstr process performance proposed scheme validated simulation results comparing conventional counterparts integral performance criteria viz integral square error ise integral absolute error iae integral time weighted absolute error itae ega implemented cstr system revealed reduction ise equal sampling interval compared conventional results show ega based nonlinear pid suitable servo regulatory operations
ankylosing spondylitis chronic inflammatory autoimmune disease characterized typically axial arthritis prototype group disorders called spondyloarthropathies believed common clinical manifestations genetic predisposition date exact etiology remains unclear past years however role genetic susceptibility epigenetic modifications caused environmental factors extensively surveyed respect pathogenesis resulted important advances review article focuses recent advances field research including hla non hla susceptibility genes identified genome wide association studies gwas aberrant epigenetic modifications gene loci associated hla genes significantly linked susceptibility include hla subtypes numerous non hla genes ubiquitination aminopeptidases mhc class presentation molecules like erap also reported moreover epigenetic modifications occurred summarized taken together findings presented review attempt explain circumstance genetic variations epigenetic modifications involved triggering development nonetheless several unanswered dark sides continue clog exhaustive understanding future researches field epigenetics carried extend vision etiopathogenesis
human immunodeficiency virus hiv hepatitis virus hcv treatment hcv pegylated interferon ribavirin ifn rbv associated neurocognitive psychiatric abnormalities goal research prospectively evaluate neurocognitive functioning among group hcv mono infected hiv hcv infected patients first weeks ifn rbv treatment accounting practice effects normal variations change time variations ifn rbv treatment exposure forty four hcv mono infected hiv hcv infected patients enrolled prospective study patients beginning ifn rbv chronic hcv infection patients administered depression inventory measure fatigue structured psychiatric interview neurocognitive battery baseline weeks initiation treatment analyses conducted explore possible associations neurocognitive functioning following hiv hcv infection hcv mono infection ifn rbv treatment exposure psychiatric status liver disease stage medical characteristics baseline significant differences two groups neuropsychiatric neurocognitive function mono infected group significantly higher reports fatigue course weeks treatment controlling practice effects hiv hcv infected patients experienced significantly greater declines memory global neurocognitive functioning well characterized sample mono infected infected patients appears persons hiv hcv infection potentially vulnerable neurocognitive sequalae hcv treatment
computer programming regarded difficult skill learn researchers often learners metacognition identified important factor successful learner learning computer programming metacognitive educational psychology generally described monitoring controlling activities one cognition researchers examined metacognitive awareness inventory identify relates student academic achievement school universities research work empirical research conducted using mai inventory objective examine correlation metacognitive awareness grade point average gpa performance introductory programming course universities malaysia experiment result indicates positive relationship metacognitive awareness learning success introductory programming course universities
article presents outcomes recent study carried among engineering professionals academics egypt propose criteria based energy efficiency rating system existing buildings discusses use multiple criteria decision making technique namely analytic hierarchy process ahp developing weights proposed rating system criteria generally reviews use ahp develop building energy rating systems ahp approach criteria weighting applied countries present study distinctively applied developing proposed rating system existing buildings egypt study nine energy rating criteria identified thoroughly comparing analyzing internationally established green building sustainability rating systems existing buildings leed breeam green globes energy star igbc pearl rating system estidama survey conducted collect opinions egyptian engineering professionals regarding relative priority identified criteria determine according opinions participants criteria mandatory optional existing buildings seeking become greener using alip weights developed optional criteria representing relative importance based performed analysis resulting rating criteria one mandatory prerequisite minimum energy performance eight optional credits descending relative weights use renewable energy sources building envelope efficiency strategies use energy efficient appliances equipment building systems automation controllability eco friendly refrigerants fire suppression systems operation maintenance practices metering sub metering building zones systems finally building related transportation impact
background androgen deficiency associated increased risk atherosclerosis cardiovascular peripheral arterial disease although biochemical molecular mechanisms underlying risk remain unclear higher testosterone tst levels correlate significant immunoprotective molecular cellular responses group previously demonstrated female sex hormones influence vascular pathogenesis via inflammatory modulated matrix metalloproteinase mmp regulation investigated role androgen replacement therapy modulation hormonally responsive pathways could playing role development vascular pathogenesis methods aged orchiectomized male rats underwent tst supplementation per controlled release pellet implantation young aged intact groups served controls serum collected analyzed enzyme linked immunosorbent assays qualitative cytokine screening quantitative multiplex analyses human aortic smooth muscle cells treated alpha dihydrotestosterone dht interleukin beta beta stimulation quantitative polymerase chain reaction ingel zymography used assay effect mmp expression activity results subphysiological physiological supraphysiological levels tst achieved tst pellet implants vivo respectively inflammatory arrays indicated interleukin cytokines specifically elevated subphysiological level tst whereas tst supplementation decreased interleukins supraphysiological tst resulted significant increase mmp tissue inhibitor metalloproteinase timp vivo pretreatment slightly increased membrane type mmp mmp mmp expression low mid level dht exposure vitro although trends statistically significant conclusions demonstrate proinflammatory modulator indicate mmp independent mechanisms may play role downstream induced inflammatory signaling dysfunctional vascular remodeling future vivo studies examine tst supplementation acute inflammatory response vascular injury mmp modulated vascular disease elsevier inc rights reserved
article apply singularity structure analysis test extended dimensional fifth order kdv equation integrability proven generalized equation passes painleve test integrability three distinct cases two cases agreement known results new integrable equation first given new integrable equation employ bell polynomial method construct bilinear forms bilinear backlund transformation lax pair infinite conversation laws systematically soliton solutions new integrable equation derived propagations collisions multiple solitons shown graphs
letter detail modular approach measuring secondary physical emotional effects ambient intelligence ami technology traffic using case merges highway assess results system advises driver change early lane left create space merging cars downstream tested using cellular automata simulation indirect impact system downstream namely remaining lane changes merge lane innermost lane proceed evaluated using time discrete space continuous microscopic traffic simulation tool yields detailed results concerning driver interactions also used derive estimate driver anger situation used real geographic traffic psychological data test system different models used accomplish various tasks approach yields surprisingly negative results concerning indirect emotional impact ami intervention may due nature lane changing model used chosen parameters argue approach also applicable similar types systems different data model types suited different scenario elements
present parallel local search approach obtaining high quality solutions fixed charge multicommodity network flow problem fcmnf approach proceeds improving given feasible solution solving restricted instances problem flows certain commodities fixed solution commodities locally optimized derive multiple independent local search neighborhoods arc based mixed integer programming mip formulation problem explored parallel scalable parallel implementation takes advantage hybrid memory architecture modern platforms effectiveness mip solvers solving small problems instances computational experiments fcmnf instances literature demonstrate competitiveness approach state art mip solvers heuristic methods elsevier ltd rights reserved
student cheating well known topic large number references literature paper presents discusses role assessment rules vehicle cheating minimization related delivered work context computer programming courses single best solution present classification cheating behaviors provides guideline teacher reflection designing course assessment rules
purpose review drug administration might optimized incorporating pharmacokinetic dynamic principles control engineering theories review gives update actual status target controlled infusion tci closed loop computer controlled drug administration ongoing research field recent findings tci becoming mature technology clinically used many countries nowadays proven safety nevertheless changing populations might require adapting established models tci requires accurate models new models developed incorporated pumps allow general use technology closed loop administration hypnotic drugs using electro encephalographic derived controlled variable well studied shown outperform manual administration computer administration drugs fluids studied recently feasibility shown systems controlling multiple components anaesthesia work required show clinical safety efficiency summary evidence literature increasing tci closed loop technology could assist anaesthetists optimize drug administration anaesthesia
primary care providers tasked treating acute exacerbations asthma chronic obstructive pulmonary disease must able recognize exacerbation symptoms triage patients based exacerbation severity appropriate level care early treatment bronchodilators corticosteroids followed repeated assessments treatment efficacy primary care providers also provide symptom guided action plans empower patients manage disease
algorithms hard understand novice computer science students dynamically modify values elements abstract data structures animations help understand algorithms since connect abstract concepts real life objects situations past years conducted many experiments field usage animations visualizations education showed mixed results paper review past research within field summarize recommendations regarding graphic design interactivity animations second part paper present interactive card sorting animations conceptual views goal animations help students understand main ideas differences basic sorting algorithms pedagogical experiment related animations first year computer science students selye university komarno slovakia asked fill pre test experiment interactive animations fill post test results showed animations helped students understand essential aspects sorting algorithms however participants able understand sorting algorithms detail types animations needed teach algorithms depth
background objectives negative symptoms schizophrenia related lower social functioning even non clinical samples little known distinct social consequences motivational expressive negative symptoms study focused expressive negative symptoms examined symptoms varying degrees pro social facial expressiveness smiling mimicry smiling relate social evaluations face face interaction partners social support methods examined dyadic interactions within sample non clinical participants rated motivational expressive negative symptoms clinical assessment interview negative symptoms cains collected data interaction partners smiling muscle zygomaticus major activation simultaneously electromyography assessed general amount smiling synchrony smiling muscle activations interaction partners mimicry smiling interaction partners rated willingness future interactions interactions results interaction partners participants scoring higher expressive negative symptoms expressed less willingness future interactions participants smiling behavior negatively related expressive negative symptoms also explained motivational negative symptoms mimicry smiling negative symptom domains also associated participants satisfaction social support network limitations non clinical sample relatively low levels symptoms conclusions expressive negative symptoms tangible negative interpersonal consequences directly relate diminished pro social behavior social support even non clinical samples elsevier ltd rights reserved
hereditary angioedema hae rare genetic disorder primarily caused defect inhibitor inh recurrent symptoms subcutaneous edema abdominal pain laryngeal edema also occur life threatening goes untreated hae associated inflammatory autoimmune disorders particularly lupus aim study describe cases lupus among hae patients france perform literature review lupus hae studies case detection data collection standardized form performed thanks french reference center kinin related angioedema data collected patients type hae lupus france cases systemic lupus erythematosus reported literature review cases lupus combined hae identified including female patients median patient age time first reported hae symptoms diagnosis years range years years range years respectively patients years range years years range years respectively literature review clinical manifestations hae mainly abdominal pain patients literature edema limbs levels low cases literature eighteen patients literature demonstrated hae symptoms prior lupus onset patients mean patient age lupus onset years range years patients years range years literature respectively literature patients skin manifestations renal involvement received systemic steroids treat lupus treatment danazol modify clinical expression lupus association lupus hae rare unanticipated event patients often symptomatic hae developing lupus lupus cases associated hae share characteristics lupus cases related complement deficiencies absence severity predominance cutaneous symptoms elsevier rights reserved
evidence building pathologic drive development osteoarthritis involves simple mechanical wear tear inflammatory mechanisms play important role tissue response joint injury involved development post traumatic inflammation also appears integral progression whether post traumatic spontaneous contributing evolution joint tissue degradation remodeling well joint pain patient based studies vivo models disease shed light number inflammatory pathways mediators impact various aspects disease structurally symptomatically recent work field implicated inflammatory chemokines osteoarthritis pathogenesis expression multiple chemokines receptors modulated disease patients animal models although best known effects leukocyte migration trafficking within immune system chemokines wide variety effects motile non motile cell types impacting proliferation differentiation activation cellular responses role models also demonstrated diverse effects disease exemplify wide ranging effects understanding important mediators inflammation impact joint disease whether targeted therapeutically actively investigated many groups field narrative review focuses evidence published within last years highlighting chemokine mediated pathways mechanistic involvement osteoarthritis joint tissue repair orthopaedic research society published wiley periodicals inc
objective enhance understandings impact tourette syndrome parents diagnosed youth specifically current study aimed explore identify multidimensional stressors associated parenting child adolescent australian context method part larger qualitative quantitative community based study semi structured telephone interviews mothers youth conducted regarding experiences results study identified parent child contextual factors contributed parental stress many mirroring experiences parents children chronic paediatric disorders however several specific factors also emerged data analysis highlighting unique difficulties encountered parents diagnosed youth serious deficits professional expertise services currently available community also identified conclusions findings indicate generally unacknowledged challenge parenting child equates experienced context serious chronic paediatric disorders results also indicate need psychosocial support child parent greatly improved access well informed mental health educational services australian context
background body dissatisfaction associated impairment women quality life qol date research examined relationship body dissatisfaction men qol sex differences relationship methods community sample males females living australia provided information body dissatisfaction mental health physical health related qol eating disorder symptoms data analysed using three hierarchical multiple regressions interactions body dissatisfaction sex examined results sexes increasing levels body dissatisfaction associated poorer mental physical health related qol greater psychological distress adverse associations body dissatisfaction mental health related qol body dissatisfaction psychological distress pronounced males conclusion high levels body dissatisfaction may threaten psychological physical wellbeing men women body dissatisfaction appears public health problem distinct eating disorders adverse psychological phenomena body dissatisfaction commonly discussed risk factor males historically understudied underrepresented body image research warrant increased empirical attention
background polycythemia vera essential thrombocythemia myelofibrosis clonal disorders collectively named myeloproliferative neoplasms mpn published data epidemiology mpn discovery jak mutation classifications scarce aimed study incidence rates prevalence survival mpn norway period method identified persons diagnosed mpn cancer registry norway report age adjusted incidence rates prevalence relative survival standardised mortality rates results overall age adjusted yearly incidence rate increased increased prevalence per inhabitants respectively five year relative survival slightly reduced improvement five year standardised mortality rate smr conclusions incidence rates doubled tripled years compared increment incidence rates may related identification jak mutation derived guidelines mpn slightly reduced substantially reduced
relatively new consideration proton therapy planning requirement mix patients treated different categories satisfy desired mix percentages deviations percentages impacts operational capabilities particular interest healthcare planners study investigate intelligent ways admitting patients proton therapy facility maximize total expected number treatment sessions fractions delivered patients planning period stochastic patient arrivals penalize deviation patient mix restrictions propose markov decision process mdp model provides useful insights determining best patient admission policies case unexpected opening facility shows appointment cancellations etc order overcome curse dimensionality larger realistic instances propose aggregate mdp model able approximate optimal patient admission policies using worded weight aggregation technique models applicable healthcare treatment facilities throughout united states motivated collaboration university florida proton therapy institute ufpti
brain derived neurotrophic factor bdnf valmet polymorphism associated cortisol responses stress gender differences reported although findings entirely consistent evaluate role valmet genotype gender cortisol responses stress conducted min mental stress protocol including four tasks four rest periods blood cortisol collected assay immediately task rest period significant two way interaction valmet genotype gender observed total area curve auc total cortisol response time val val genotype associated larger cortisol response stress compared met group women men contrast analyses val val met group stress task showed similar increased cortisol pattern among women val val genotype among men present findings indicate gender differences effect valmet genotype cortisol responses stress protocol extend evidence importance gender role vamet modulation stress reactivity subsequent depression prevalence studies underlying mechanism need investigated may provide insight prevention intervention treatment strategies target high risk elsevier ltd rights reserved
little work focused underlying mechanisms may link financial strain smoking processes current study tested hypothesis financial strain would exert indirect effect cognitive based smoking processes via depressive symptoms three clinically significant dependent variables linked maintenance smoking evaluated negative affect reduction motives negative mood abstinence expectancies perceived barriers quitting participants included adult daily smokers age years female recruited community participate self guided unaided psychological pharmacological intervention smoking cessation study results indicated depressive symptoms explain part relation financial strain smoking motives negative affect reduction negative mood abstinence expectancies perceived barriers quitting results indicate smoking interventions individuals high levels financial strain may potentially benefit addition therapeutic tactics aimed reducing depression elsevier ltd rights reserved
linear single degree freedom sdof oscillator fractional order pid controller acceleration feedback investigated averaging method approximately analytical solution obtained moreover numerical solution system obtained step order method power series method progressively effects parameters fractional order pid controller dynamical properties characterized new equivalent parameters proportional component fractional order pid controller characterized form equivalent mass integral component fractional order pid controller denoted form equivalent linear damping equivalent mass differential component fractional order pid controller denoted form equivalent linear negative damping equivalent mass equivalent parameters could distinctly illustrate effects parameters fractional pid controller dynamical response comparison analytical solution numerical results made satisfactory agreement verifies correctness approximately analytical results effects parameters fractional order pid controller control performance analyzed performance parameters time response finally robustness fractional order pid controller based acceleration feedback demonstrated control sdof quarter vehicle suspension model
analyzing retrieval accuracy precision important element space based retrievals however error analysis sometimes challenging perform rigorously subtlety multivariate statistics help address issue revisit fundamentals multivariate statistics help reveal statistical essence associated error analysis show related statistical methodology useful revealing intrinsic discrepancy relation retrieval error nonzero variate state zero variate one study suggests two scenarios essentially yield magnitude accuracy latter scenario yields better precision former also use methodology obtain rigorous framework systematically explore broadly used approximate framework analyzing retrieval errors approximate framework introduces errors due essential often forgotten fact priori climatology reality never equal true state due nature problem considered realistic numerical simulations produce synthetic spectra may appropriate remote sensing data specific exploration highlighted retrieval simulations utilizing approximate framework may universally satisfactory assessing accuracy precision xco retrievals errors ppm ppm respectively snr situ measurements needed understanding issue related implications
purpose study assess cognitive function papillary thyroid cancer one type differentiated thyroid cancer identify factors associated cognitive dysfunction korean women treated papillary thyroid cancer post thyroidectomy healthy women similar age educational level performed attention working memory tests completed self report questionnaires cognitive complaints psychological distress symptom distress cultural characteristics comparative multivariable regression analyses performed determine differences cognitive function possible predictors neurocognitive performance cognitive complaints thyroid cancer survivors performed perceived function significantly worse tests attention working memory compared individuals without thyroid cancer regression analyses found thyroid cancer older age lower educational level associated worse neurocognitive performance greater fatigue sleep problems higher levels childrearing burden thyroid cancer associated lower perceived effectiveness cognitive functioning findings suggest women receiving thyroid hormone replacement therapy thyroidectomy papillary thyroid cancer risk attention working memory problems coexisting symptoms culture related women burden affected perceived cognitive dysfunction health care providers assess cognitive problems women thyroid cancer intervene reduce distress improve quality life
newer complex multi core systems important understand application runtime behavior able debug execution detect possible problems bottlenecks finally identify potential root causes execution traces usually contain precise data application execution analysis abstraction multiple levels provide valuable information insights application runtime behavior however multiple abstraction levels becomes increasingly difficult find exact location detected performance security problems tracing tools provide various analysis views help users understand application problems however pre defined views often sufficient reveal analysis aspects underlying application declarative approach enables users specify build custom analysis views based knowledge requirements problems useful effective paper propose generic declarative trace analysis framework analyze comprehend visualize execution traces enhanced framework builds custom analyses based specified modeled state extracted system execution trace stored special purpose database proposed solution enables users first define different analysis models based application requirements visualize models many alternate representations gantt chart chart etc finally filter data get highlights detect potential patterns several sample applications different operating systems shown using trace events gathered linux windows kernel user space levels
low impact development lid technologies bioretention areas rooftop rainwater harvesting xeriscaping control stormwater runoff supply non potable water landscape open space study examines hybrid system combines lid technologies centralized water system lessen burden conventional system defined stormwater collection water supply infrastructure conventional landscaping choices city atlanta study scope limited five single family residential zones sfzs classified four multi family residential zones mfzs classified population density increases persons per performed life cycle assessment lca comparison using traci simulate impacts ecosystem human health natural resources quantified impact freshwater consumption using freshwater ecosystem impact fei indicator test results indicate higher lca single score zones low population density however difference becomes negligible population density increases incorporating lid sfzs mfzs reduce potable water use average respectively however water savings negligible zones high population density due diminished surface area per capita available lid technologies results demonstrate lid technologies effectively reduce outdoor water demand therefore would good choice decrease water consumption impact city atlanta higher education press springer verlag berlin heidelberg
high quality drinking water exits modern treatment works yet water quality degradation discolouration continues occur within drinking water distribution systems dwds discolouration observed globally suggesting common process despite variations source treatment disinfection network configurations primary cause discolouration identified mobilisation particulate material pipe walls verified prediction discolouration distribution systems podds model uses measurable network hydraulics simulate response paper cohesive properties discolouration material explored hypothesised simulating turbidity response podds model actually describing development cohesive strength behaviour biofilms applying concept therefore facilitate rapid simple assessment dwds biofilm activity review findings podds studies conducted internationally presented focussing macro observable aspects discolouration compared contrasted associated biofilm studies consider discolouration material micro scale combining results past studies improve understanding interactions microbial ecology discolouration discussed view dwds operational strategies safeguard optimise drinking water supply
study examined whether approach avoidance related behaviour elicited facial affect moderated presence observer irrelevant trigger may influence observer attributions actor emotion participants shown happy disgusted neutral facial expressions half presented plausible trigger expression drink approach avoidance related behaviour indexed explicitly questionnaire measuring intentions implicitly manikin version affective simon task measuring automatic behavioural tendencies absence observer irrelevant trigger participants expressed intention avoid disgusted approach happy facial expressions participants also showed stronger approach tendency towards happy towards disgusted facial expressions presence observer irrelevant trigger moderating effect decreasing intention approach happy avoid disgusted expressions trigger moderating effect approach avoidance tendencies thus influence observer irrelevant trigger appears reflect controlled automatic process
electromagnetic forces applied stator electric machine highly contribute overall acoustic noise made steel stator core also considered main transfer path contributor electrical machine mass stiffness moreover composed axially stacked steel laminations reduce eddy current losses electric motor operation hundreds laminas behave like solid steel makes modelling process non trivial systematic approach followed paper starts modal testing single sheet progressively increasing number laminas stack corresponding length full stator reached therefore effects inter laminar interference structural behavior investigated different number laminas stack specific nonlinearities checks also carried characterize different structures preliminary results show promising linear behavior radial type excitations whilst axial components present possibly high nonlinearities
objective investigate survival rate fracture strength bending moments loading fracture fracture modes different designs zirconia abutments dynamic loading thermocycling compare values titanium abutments methods total abutment samples divided test groups samples group study included following groups group cad cam produced zirconia abutments group titanium abutments group zirconia abutments adhesively luted titanium base group prefabricated allzirconia abutments group zirconia abutments glass soldered titanium base half number samples group exposed million loading cycles years simulation chewing simulator samples survived artificial aging later tested fracture strength universal testing machine remaining samples group directly tested fracture strength results samples exposed years artificial aging survived except six samples one group group surviving samples later fracture tested universal testing machine bending moments values follow exposed groups group group group group group non exposed groups group group group group group except group values higher exposed groups although statistically difference one piece zro abutment group group group exhibited lower values two piece zro abutment groups group group showed similar values fracture modes like titanium abutment group titanium abutment group showed highest values bending moments among groups conclusion implant abutment connection area appeared influence bending moment value fracture mode tested abutment groups found weakest part internal connection one piece zirconia abutment titanium base two piece zirconia abutment worked substitute weakest part abutment therefore titanium base reinforce fracture strength zirconia abutment
moving process leveling erecting mechanism complicated involves six hydraulic cylinders research established mathematical model optimized moving process leveling erecting mechanism kinematic analysis mechanism accomplished mathematical model hydraulic system established working scheme designed consisting workflow trajectory planning leveling strategy control method mechanical hydraulic control models respectively established pro adams amesim simulink software simulation carried validate designed scheme experiment completed platform results simulation experiment indicate designed scheme feasible fuzzy adaptive pid controller excellent effect controlling leveling erecting mechanism
background working victims perpetrators child sexual abuse shown cause secondary traumatic stress sts child protection professionals aims examine role gender personality development secondary trauma responses methods study internet child abuse investigators icais two police forces participants completed personality test together tests anxiety depression burnout sts post traumatic stress disorder assess secondary trauma data normally distributed results analysed using independent test pearson correlation linear regression results among study subjects females males higher incidence sts investigators female introverted neurotic however lower levels sts participants study found studies conclusions psychological screening surveillance icai teams help identify risk factors development sts identify additional support may required
recent advancements micro object contactless conveyers becoming essential part biomedical sector help avoid infection damage occur due external contact context smart micro conveyor devised field programmable gate array fpga based system employs smart surface conveyance along omnivision complementary metal oxide semiconductor cmos camera micro object position detection tracking specific fpga based hardware design vhsic high speed integrated circuit hardware description language vhdl implementation realized done without employing nios processor system programmable chip sopc builder based central processing unit cpu core keeps system efficient terms resource utilization power consumption micro object positioning status captured embedded fpga based camera driver communicated image processing decision making command ipdc module ipdc programmed run personal computer appropriate embedded system ipdc decisions sent back fpga pilots smart surface accordingly way automated closed loop system employed convey micro object towards desired location devised system architecture implementation principle described functionality also verified results confirmed proper functionality developed system along outperformance compared solutions
aberrant expression mirnas involved several carcinogenic processes including tumor growth metastasis angiogenesis aim study determine role mir gastric cancer angiogenesis situ hybridization performed set tissue microarray samples assess difference mir expression vessels tumor tissues normal gastric mucosa vitro ectopic expression mir disturbed tubular structure inhibited migration endothelial cells motility tube formation rescued mir downregulated moreover mir suppressed endothelial cell sprouting fibrin bead sprouting assay subsequently identified robo target mir endothelial cells determined responsible effect mir tumor angiogenesis vivo local injection mature mir xenografted tumors disrupted vessel plexus thus inhibited tumor growth taken together study demonstrated anti angiogenic role mir gastric cancer indicated delivery mir may potential therapeutic strategy inhibit tumor angiogenesis elsevier rights reserved
objectiveto systematically review literature perceived barriers facilitators help seeking eating disorders methodthree databases pubmed psychinfo cochrane searched using keywords medical subject headings mesh terms retrieved abstracts double screened relevant papers double coded qualitative quantitative studies included reported perceived barriers facilitators towards seeking help eating disorders barriers facilitators extracted included papers coded themes prominent barriers facilitators determined number studies reporting theme resultseight qualitative three quantitative two mixed methods studies met inclusion criteria current review prominent perceived barriers help seeking stigma shame denial failure perceive severity illness practical barriers cost treatment low motivation change negative attitudes towards seeking help lack encouragement others seek help lack knowledge help resources facilitators help seeking reported six studies prominent themes identified presence mental health problems emotional distress concerns health discussionprograms targeting prevention early intervention eating disorders focus reducing stigma shame educating individuals severity eating disorders increasing knowledge around help seeking pathways eating disorders wiley periodicals inc int eat disord resumen objetivoshacer una revision sistematica literatura acerca las barreras facilitadores percibidos busqueda ayuda trastorno alimentario metodose exploraron tres bases datos pubmed psychinfo cochrane usando palabras clave terminos titulos medicos mesh los resumenes recuperados fueron doblemente revisados los articulos relevantes fueron doblemente codificados incluyeron estudios cualitativos cuantitativos reportaban barreras facilitadores percibidos hacia busqueda ayuda para trastornos alimentarios las barreras facilitadores fueron extraidos los articulos incluidos codificados por temas las barreras facilitadores mas prominentes fueron determinados por numero estudios que reportaron cada tema resultadosocho estudios cualitativos tres cuantitativos dos mixtos reunieron los criterios inclusion para revision las mas prominentes barreras percibidas cuando busca ayuda fueron estigma verguenza negacion fallas percepcion severidad enfermedad barreras practicas costo del tratamiento poca motivacion cambio actitudes negativas hacia solicitud ayuda falta estimulo otros para buscar ayuda falta conocimiento acerca cuales son los recursos apoyo los facilitadores busqueda ayuda fueron reportados seis estudios siendo los temas identificados como mas prominentes presencia otros problemas salud mental estres emocional preocupaciones acerca salud discusionlos programas enfocados prevencion intervencion temprana los trastornos conducta alimentaria deben enfocarse reducir estigma verguenza educacion los individuos acerca gravedad los trastornos alimentarios incrementar informacion acerca los caminos para buscar ayuda para los trastornos conducta alimentaria int eat disord
functional connectivity studies based resting state functional magnetic resonance imaging fmri shown alterations brain networks associated self referential processing cognitive control somatosensory processing anorexia nervosa study aimed investigate functional connectivity resting state networks rsns homogenous subsamples individuals restrictive current recovered relationship core eating disorder psychopathology fmri scans obtained female individuals restrictive females recovered restrictive female healthy controls independent components analysis revealed set functionally relevant rsns previously reported literature dual regression analysis showed decreased temporal coherence within lateral visual auditory rsns individuals current recovered compared healthy individuals decreased connectivity also found regions associated somatosensory processing consistent reduced interoceptive awareness body image perception characteristic widespread gray matter reductions also found groups differences functional connectivity longer significant maps added covariate dual regression analysis raises possibility deficits somatosensory interoceptive processing observed may part underpinned exacerbated reductions
aim study improve hybrid dual curable cyanate ester boron phosphate composites via sequential thiol ene photopolymerization thermal polymerization high performance applications aerospace electronic devices novel diallylbisphenol dicyanate ester badcy allyl group containing cyanate ester synthesized characterized badcy silicon containing monofunctional thiol compound trifunctional thiol compound boron phosphate cured using ultraviolet thermal methods using thiol ene system cyanate ester formulations normally prepared high temperatures prepared room temperature study maintains ease application cyanate esters thermal stability flammability thermal conductivity samples evaluated thermogravimetric analysis tga differential scanning calorimetry dsc limiting oxygen index loi laser flash method respectively samples characterized following analysis gel content water absorption capacity stress strain test hydrophobicity samples determined contact angle measurements moreover surface morphology samples investigated scanning electron microscopy sem eds obtained results prove composites good thermal mechanical properties help easier preparation techniques used many applications aerospace electronic devices materials engineering elsevier rights reserved
effective way learn computer programming sit side side front computer tutor peer write code together discuss happens code executes bring kind person interaction online setting developed codechella multi user web based program visualization system enables multiple people collaboratively write code together explore automatically generated visualization execution state using multiple mouse cursors chat via embedded text box nine months live deployment educational website www pythontutor com people cities across countries participated codechella sessions tutoring collaborative learning sessions connected participants different cities different countries participants actively engaged program visualizations chatting showed affective exchanges encouragement banter indicated signs learning lower three levels bloom taxonomy remembering understanding applying knowledge
background numerous studies document health benefits physically active lifestyle relatively document hazards physical activity requirement physical fitness complete mission united states military services vested interest understanding benefits risks physical activity including exercise sports one risks injury rates proportion injuries caused exercise sports related esr activities reported previously across services purpose purposes population survey document rates proportion injuries caused esr activities among military personnel compare rates across military services describe causes types esr injuries well associated days limited activity study design descriptive epidemiology study methods defense manpower data center administered web based status forces survey active duty service members random sample active duty personnel servicemembers completed survey included questions injuries cause exercise sports previous year responses weighted produce population estimates injury rates injury esr injury percentage distributions used describe activities injury types days limited activity contributing factors esr injuries results servicemembers sustained injury cause previous year esr injury thus injuries esr injuries esr injury rates ranged navy marine corps running accounted esr injuries forty percent esr injuries sprains strains indicator injury severity esr injuries required weeks limited activity conclusion study quantified overall incidence injuries large proportion caused exercise sports among military personnel population healthy physically active adults prevention strategies focus running weight training basketball football recommendations include adherence evidence based practices reduce occurrence esr injuries
world first implantable total artificial heart designed vladimir demikhov fourth year biology student voronezh soviet union prototype device demikhov must used apparatus extracorporeal blood circulation invented sergei bryukhonenko moscow device size dog native heart consisted two diaphragm pumps brought motion electric motor dog implanted device lived hours addition prototype preconditions demikhov artificial heart creation manual dexterity expertise animal physiology mechanistic worldview
ever growing demand location independent access autonomous decentralized systems ads anomaly detection scheme industrial ethernet highly satisfied demanding real time reliable industrial applications becomes one pressing subjects ads paper present innovative approach build traffic model based structural time series model chemical industry system basic structural model decomposes time series four items established stationary analysis industrial traffic parameters model identified state space model conducted training sequence using standard kalman filter recursions algorithm furthermore performance state space model evaluated experimental results confirm significant improvement detection accuracy validity abnormal data localization elsevier rights reserved
background treatment vitiligo narrowband ultraviolet light nbuvb important component current standard care however consistent guidelines regarding dosing administration nbuvb vitiligo reflected varied treatment practices around world objective create phototherapy recommendations facilitate clinical management identify areas requiring future research methods vitiligo working group vwg phototherapy committee addressed questions regarding administration phototherapy conference calls members photomedicine society group phototherapy experts surveyed regarding phototherapy practices results based comparison analysis survey results expert opinion discussion held conference calls expert recommendations administration nbuvb phototherapy vitiligo created limitations several areas required research final recommendations could made addition standardized methodology used literature review assess strength evidence development recommendations conclusion set expert recommendations vwg based prescribing practices phototherapy experts around world create unified broadly applicable set recommendations use nbuvb vitiligo
introduction tryptophan depletion established method influence serotonergic system mood purpose study examine effect different ambient light conditions measured serotonin associated plasma levels visual analog scale vas healthy females methods thirty eight healthy female allele carriers serotonin transporter promoter gene httlpr administered dim light conditions sub group participants repeated procedure randomized two additional light conditions respectively prior following administration various variables serotonin associated plasma levels vas measured due normal distributed data non parametric statistical tests used results overall analysis showed significant mood lowering effect moreover decreased measured serotonin associated plasma levels significantly significant differences varying light conditions found vas plasma tryptophan greatest effect condition conclusion results study showed influence even slight differences ambient light intensity effect concerning mood well serotonergic system elsevier ireland ltd rights reserved
paper presents network security laboratory teach data analysis detecting tcp covert channels laboratory mainly designed students electrical engineering open students technical disciplines similar background covert channels provide method leaking data protected systems major concern big enterprises governments inclusion covert channels curricula network security students network data analysts therefore considered valuable extension lab exercises presented students learn covert channels tcp network traffic hidden detected since detection covert channels requires depth understanding protocol standards typical behavior tcp flows lab also provides playground students deepen communication networks knowledge students learn use interpret statistical analysis discover abnormal patterns footprints network data also trained deal noisy scenarios increase ambiguity uncertainty laboratory first implemented winter semester class students wien austria experience showed students consolidated targeted skills well increased interest topics explored exercises datasets introduced network security advanced lab made publicly available
suppose exactly sparse vector present class sparse matrices corresponding algorithm call short fast sho high probability reconstruct sho algorithm related invertible bloom lookup tables recently introduced goodrich two important distinctions sho relies linear measurements robust noise sho algorithm first simultaneously following properties requires measurements bit precision measurement arithmetic operation log corresponds desired relative error reconstruction computational complexity decoding arithmetic operations encoding arithmetic operations reconstruction goal simply recover single component instead significant probability done constant time constants independent problem parameters desired probability success wide range parameters properties information theoretically order optimal addition sho algorithm works fairly general ensembles sparse random matrices robust random noise random approximate sparsity large range particular suppose measured vector equals correspond source tail measurement noise respectively reasonable statistical assumptions decoding algorithm reconstructs estimation error parallel parallel parallel parallel sho algorithm works high probability still requires steps measurements log bit numbers contrast existing algorithms focus worst case model known omega log measurements log bit numbers necessary algorithm good empirical performance validated simulations
adaptive regional total electron content space distribution model based data igs international gps service geophysics international network gps stations proposed article method spherical harmonic analysis selection spectrum approximating harmonic greatest contribution applied creation model method essence consists spherical harmonics series spectrum selection harmonics orthogonal projection exceeding input data errors level appropriate number times used approximating function comparative estimation results obtained least squares process throug offered method executed usage least squares process solving problem spherical harmonics analysis reconstructing space distribution total electronic contents poor conditionality normal equations system results considerable errors approximating strongly dependent selected length series selection spherical harmonics series spectrum greatest contribution allows regularize normal equations system solution increase accuracy stability model used increase accuracy detecting satellite radionavigation system users relative navigation mode ionospheric monitoring etc
article reply ferguson kilburn critique meta analysis violent video game effects anderson rely well established methodological statistical theory empirical data show claims bias misinterpretation part simply wrong one systematically exclude unpublished studies meta analytic reviews evidence publication selection bias data purposely exclude certain studies included studies met inclusion criteria although ferguson kilburn believe effects obtained trivial size larger many effects deemed sufficiently large warrant action medical violence domains claim media violence scholars attempting create false crisis red herring
aimed evaluate association sex hospitalization characteristics psychotic disorders identified acute hospitalizations psychotic disorders patients younger older years hospital database addition identified patients prescribed intramuscular risperidone clozapine discharge results showed women younger years lower proportions hospitalizations involuntary hospitalizations men age group women older years higher proportions hospitalizations similar proportion involuntary hospitalizations women younger years prescribed similar doses intramuscular risperidone lower doses clozapine women older years prescribed higher doses intramuscular risperidone weeks clozapine men age group women reproductive years better hospitalization characteristics men measures
studies examined association parenting behaviors childhood post traumatic stress disorder ptsd yielded mixed findings clarify role parenting childhood ptsd conducted systematic review meta analysis studies investigated association parenting youth ptsd symptoms total negative parenting behaviors overprotection hostility accounted variance childhood ptsd symptoms positive parenting behaviors warmth support account variance negative positive parenting child ptsd symptom associations statistically differ magnitude moderator analyses indicated methodological factors trauma variables may affect association parenting child ptsd studies relied upon questionnaire measures general parenting style studies predominantly cross sectional weaker evidence found longitudinal studies given small number high quality studies available provisional recommendations role parenting childhood ptsd made authors published elsevier ltd
transition phenomenon cycle pulse optical solitons pure modified korteweg vries mkdv pure sine gordon regime described non autonomous mkdv sinh gordon equation time dependent coefficients based bell polynomials hirota method symbolic computation bilinear forms soliton solutions equation obtained backlund transformations bts binary bell polynomial bilinear forms obtained virtue bts ablowitz kaup newell segur system lax pair infinitely many conservation laws equation derived well
paper propose algorithm robustly fusing digital surface models dsms different ground sampling distances confidences using explicit surface priors obtain locally smooth surface models robust fusion dsms achieved minimizing distance pixel solution input dsm approach similar pixel wise median outliers discarded incorporate local planarity assumption additional constraint optimization problem thus reducing noise compared pixel wise approaches optimization also inherently able include weights input data therefore allowing easily integrate invalid areas fuse multiresolution dsms weight input data complete optimization problem constructed variational optimization problem convex energy functional solution guaranteed converge toward global energy minimum efficient solver presented solve optimization reasonable time running real time standard computer vision camera images accuracy algorithms quality resulting fused surface models evaluated using synthetic data sets spaceborne data sets different optical satellite sensors
paper analyze extend mesh free algorithms three dimensional data transfer problems partitioned multiphysics simulations first provide direct comparison mesh based weighted residual method using common refinement scheme two mesh free algorithms leveraging compactly supported radial basis functions one using spline interpolation one using moving least square reconstruction comparison assess conservation accuracy data transfer obtained methods varying set geometries without curvature sharp features functions without smoothness varying gradients results show mesh based mesh free algorithms complementary cases demonstrated perform better focus mesh free methods developing set algorithms parallelize based sparse linear algebra techniques includes discussion fast parallel radius searching point clouds restructuring interpolation algorithms leverage data structures linear algebra services designed large distributed computing environments scalability new algorithms demonstrated leadership class computing facility using set basic scaling studies scaling studies show problems reasonable load balance new algorithms spline interpolation moving least square reconstruction demonstrate strong weak scalability using mpi processes billions degrees freedom data transfer operation elsevier inc rights reserved
geotextiles thin polymeric materials widely used geotechnical environmental hydraulic applications employed infiltration basins designed collect improve quality storm runoff waters infiltration surrounding soil introduction geotextiles subsoil infiltration basins may significantly influence flow transfer pollutants present storm runoff waters solute form associated colloidal particulate phases objective work study influence nonwoven geotextile conservative solute colloidal transport sandy gravel porous media saturated unsaturated conditions solute colloid transport columns containing soil amended geotextile characterized injecting tracer solution suspension colloidal particles constant flow rate saturated unsaturated conditions flow pattern described using mim model implemented hydrus code results showed nonwoven geotextiles increase flow homogeneity effect flow homogenization depended soil heterogeneity degree water saturation colloidal retention efficiency column scale also modified presence geotextiles homogenizing flow increased filter capacity soil thereby decreasing pollutant transfer colloidal form elsevier ltd rights reserved
low serum vitamin increased parathormone levels found associated depression stress wintering expedition healthy male subjects period year antarctica continuous daylight summer dark polar winter affect endogenous vitamin production long term effects bone health need studied purpose vitamin plays significant role calcium bone mineral metabolism also affects cardiovascular psychological cognitive functions ultraviolet radiation component sunlight shows marked seasonal variation antarctica influences synthesis vitamin depression mood disorders associated extreme photoperiod study attempted gauge alteration vitamin homeostasis antarctica effect bone mineral metabolism mood period year materials methods twenty male subjects wintered india antarctic base maitri degrees degrees november december studied fasting serum samples collected baseline months months serum hydroxyvitamin intact parathyroid hormone pth total alkaline phosphatase alp calcium phosphate beck depression inventory bdi positive negative affect scale panas perceived stress scale used measure depression affect stress results mild vitamin deficiency present two subjects arrival increased seven subjects polar winter months mean score bdi screen depression significantly higher midwinter compared baseline value subjects met criteria minor depression higher pth levels months correlated higher panas score mean values calcium inorganic phosphorus alp comparable course expedition conclusion low light exposure dark polar winter lower vitamin increased intact pth levels found associated depression year antarctic residence low dietary intake decreased solar radiation exposure polar winter reduce serum vitamin levels otherwise healthy individuals suggests supplementation may necessary
work three different diameter energy harvesters driven turbulent air flow rainwater designed experiments conducted first air driven harvesters gain insight energy conversion process unlike conventional blade involved systems present setup involves using number rotating compact discs closely spaced attached central shaft magnet attached air flow excitations set different levels harvester performances measured open closed loop electrical circuits results show approximately electricity produced parametric analysis conducted highlight effect system parameters disc diameter number exhaust flow rates inter disc distance performance gain insight optimum design numerical simulations conducted understand flow physics finally harvester used harness energy rainwater compared size air driven harvester rainwater driven one working efficiently terms overall energy conversion efficiency maximum electric current practical demonstration conducted using electricity generated power red light emitting diode led elsevier ltd rights reserved
objective present study examine symptoms posttraumatic stress disorder ptsd may confer drinking risk students trauma histories complete college move toward independent adulthood students completed assessments trauma posttraumatic stress alcohol use consequences four time points year following fourth year college students transitioned college environment whereas others examined transition status moderated within person associations changes ptsd corresponding changes alcohol outcomes time using multilevel modeling examined differences within person ptsd alcohol associations comparing students continuing fifth year seniors graduated pursuing graduate education graduated left university setting alcohol use consequences tended decline average fourth fifth year post matriculation yet within person increases posttraumatic stress symptomatology across fifth year associated greater alcohol consequences students left university setting data suggest transition college may important developmental context associated increased vulnerability negative consequences stress related drinking findings may important implications campus based prevention efforts geared toward facilitation successful transition independent adulthood
isogeometric analysis iga new analysis method unification computer aided design cad computer aided engineering cae use nurbs basis functions modelling analysis bottleneck meshing avoided seamless integration achieved cad computational geometry concepts iga new analysis community though steady growth literature details calculations explanations examples reported content paper complimentary existing literature addresses gaps includes summary literature overview methodology step step calculations matlab codes example problems static structural modal analysis appropriate places comparison finite element analysis fem also included familiar fem appreciate iga better
aims hypothesisinsulin resistance risk factor assess development micro macro vascular complications type diabetes however diabetes management adults limited difficulty lacking simple reliable methods estimate insulin resistance aim study develop new model estimate via clinical parameters adults methodsa total adults adulthood onset childhood onset recruited quota sampling overnight insulin infusion stabilize blood glucose mmol underwent minute euglycemic hyperinsulinemic clamp glucose disposal rate gdr mgkg min calculated data collected last minutes test demographic factors age sex diabetes duration metabolic parameters blood pressure glycated hemoglobin hba waist hip ratio whr lipids collected evaluate insulin resistance age diabetes onset clinical parameters used develop model estimate lngdr stepwise linear regression resultsfrom stepwise process best model estimate insulin resistance generated including hba diastolic blood pressure whr age diabetes onset enter models proposed following new model estimate gdr adults lngdr xhba xdiastolic blood pressure mmhg xwhr adjusted conclusions interpretationinsulin resistance adults living estimated using routinely collected clinical parameters simple model provides potential tool estimating large scale epidemiological studies adults regardless age onset
electrophysiologic studies suggest autism spectrum disorder characterized aberrant anatomic functional neural circuitry normal brain development pruning synaptogenesis facilitate ongoing changes short long range neural wiring developmental disorders autism process may perturbed lead abnormal neural connectivity careful analysis electrophysiologic connectivity patterns using eeg coherence may provide way probe resulting differences neurological function people without autism general consensus electroencephalogram coherence patterns differ individuals without autism spectrum disorders however exact nature differences clinical significance remain unclear review recent literature comparing electroencephalogram coherence patterns patients autism spectrum disorders high risk autism non autistic low risk autism peers
background research studies seasonal affective disorder sad among immigrant populations scarce objective article explore associated risk protective factors prevalence winter sad sad sub syndromal sad sad summer sad among five immigrant groups living oslo norway methods oslo immigrants health study innvandrer hubro large cross sectional epidemiological survey conducted among five largest immigrant groups living oslo subjects included analysis participated survey mailed questionnaire included selected items seasonal pattern assessment questionnaire spaq hopkins symptom check list hscl variables used analysis results lowest levels sad found among sri lankan men women highest among iranians sad significantly associated country birth younger age smoking presence mental distress frequent visits general practitioner psychiatrist self reported poor health presence chronic disorders sad significantly associated country birth smoking higher levels alcohol consumption limitations spaq culturally validated poor response rate also considered limitation conclusions ethnic differences sad sad observed sri lankans lowest levels sad however need culturally validated instruments research must focus exploring protective factors sad elsevier rights reserved
interpersonal communication listeners must rapidly evaluate verbal vocal cues arrive integrated meaning utterance speaker including representation speaker feeling knowing confident relation utterance study investigated time course neural responses underlying listener ability evaluate speaker confidence combined verbal vocal cues recorded real time brain responses listeners judged statements conveying three levels confidence speaker voice confident close confident unconfident preceded meaning congruent lexical phrases positive likely perhaps event related potentials utterances combined lexical vocal cues speaker confidence compared responses elicited utterances without verbal phrase previous study jiang pell utterances combined cues speaker confidence elicited reduced responses compared corresponding utterances without phrase compared confident statements close confident unconfident expressions elicited reduced responses late positivity unconfident close confident expressions differentiated later time window effect lexical phrases confidence processing differed male female participants evidence female listeners incorporated information verbal vocal channels distinct manner individual differences trait empathy trait anxiety also moderated neural responses confidence processing findings showcase cognitive processing mechanisms individual factors governing infer speaker mental knowledge state speech signal elsevier ltd rights reserved
paper deals transfer data power line communication plc pulse width modulated pwm energy network target applications concern adjustable speed drive industrial infrastructures order implement efficient communication solution necessary model communication channel determine certain parameters like bandwidth carrier frequency modulation formats originality work methodology used determine channel model first results simulation experimental validation presented paper
aquatic habitat assessment river restoration design require geospatially explicit maps hydraulic conditions diverse mechanistic ecohydraulic models compute spatially explicit depth velocity results evaluate habitat suitability spatially function abiotic conditions study compared depth velocity results two dimensional one dimensional hydraulic models algorithms laterally discretize velocity interpolate depth velocity spatially based laplacian heat mapping approach conveyance distributed methods constitute best modelling practice compared results first time models applied three morphologically distinct reaches leveed meandering anastomosing three flows base bankfull flood flows partially regulated gravel cobble lower yuba river north central california test metrics coefficient determination median absolute residual vertical bar epsilon tilde vertical bar metrics quantified incremental uncertainty approximation incurs results make explicit cost benefit processes model selection possible finally velocity residual maps analysed identify regions processes residuals high indicating divergence assumptions paired data fell mean median depth median absolute residuals vertical bar epsilon tilde vertical bar residuals approximately within higher flows lower gradient reaches lower residuals higher velocity diverged particularly base flow anastomosing reaches one dimensional conveyance distributed assumptions performed better channel types similar vertical bar epsilon tilde vertical bar mean vertical bar epsilon tilde vertical bar median similar conveyance distributed velocity model performed best orthogonal flow assumptions obtained side channels transition backwater conveying area flows copyright john wiley sons ltd
social economic inequalities condom use adolescents reported previously also condom use declined last decade aim study describe trends use condoms setting trends may differ socioeconomic groups boys separately girls aged years attending school barcelona analyzed data three annual surveys risk factors secondary students included representative sample city population individuals previously sexual intercourse included study calculated adjusted prevalence ratios apr confidence intervals using robust poisson regression models prevalence condom use among boys among girls respectively decrease greater adolescents low socioeconomic level boys apr girls apr observed increase socioeconomic inequalities condom use adolescents highlights possible deterioration good sexual practices policies studied period
objective determine frequency sicca complex sjogren syndrome fibromyalgia patients irritable bowel syndrome ibs methods seventy seven ibs patients fulfilled rome iii criteria included study patients assessed according american college rheumatology acr criteria examination objective evidence sicca complex schirmer test tbut ocular staining score oss serological tests performed diagnosis made according american college rheumatology acr classification criteria results thirteen ibs patients dry eye detected patients oss schirmer test tbut respectively patients ibs diagnosis established two patients conclusion frequency sjogren syndrome among patients ibs relatively higher general population ibs patients questioned dryness mouth eyes necessary evaluated
paper presents design procedure low frequency integrated low pass filter suitable integrated circuit fabrication design methodology concentrated lowest power dissipation retaining electrical specifications concluded filter order elliptic filter using signal flow graph method easy optimize dynamic range system level design integrators significant sections filter circuit implemented operational amplifiers resistors capacitors order elliptic filter pass band ripple khz cutoff frequency single supply voltage
environmental sustainability assessment tools important role moving towards better world bringing knowledge raising awareness architecture civil engineering sector assessment tools help moving forward constructions less economic environmental social impacts present numerous assessment tools methods different approaches scopes analyzed numerous technical reviews however agreement method used evaluation case research paper synthetically analyzes main sustainability assessment methods construction sector comparing strengths weaknesses order present challenges spanish integrated value model sustainability assessment mives mives multi criteria decision making method based value function concept seminars experts article analyzes mives advantages weak points going methodology two representative applications end area application mives described detail along general application cases main types assessment tools methods
background prevalences multimorbidity vary european studies several methods definitions used study examine prevalence multimorbidity relation age gender educational attainment association physical mental health conditions educational attainment danish population methods cross sectional design used study prevalence multimorbidity defined two chronic conditions comorbid physical mental health conditions across age groups educational attainment levels among individuals aged years older lived capital region denmark january calculating prevalence odds ratios multimorbidity mental health conditions derived logistic regression gender age age squared education number physical conditions odds ratios mental health conditions odds ratios multimorbidity mental health conditions variable adjusted variables results multimorbidity prevalence half population aged multimorbidity prevalence inversely related educational attainment among lower secondary education versus among people postgraduate education adjusted odds ratios multimorbidity people postgraduate education compared people lower secondary education among population members physical mental health condition proportion increased people multimorbidity physical mental health comorbidity prevalent women men approximately times prevalent among older persons younger ones physical mental health comorbidity also twice prevalent among people lower secondary education among postgraduate education presence mental health condition strongly associated number physical conditions five physical conditions adjusted odds ratio mental health condition compared physical conditions conclusion multimorbidity prevalence patterns danish population comparable european populations high prevalence mental physical health conditions highlights need ensure healthcare systems deliver care takes physical mental comorbidity account higher prevalence multimorbidity among persons low educational attainment emphasizes importance health care system providing care beneficial regardless socioeconomic status
hemodynamic factors cardiovascular system hypothesized play significant role causing structural heart development thus important improve understanding velocity characteristics parameters present study wild type mouse characterize vessel geometry flow pattern wall shear stress great arteries microultrasound imaging small animals used measure blood boundary velocity great arteries subsequently specimens flow boundary conditions used dimensional reconstructions great artery aortic arch dimensions blood flow velocity data input subject specific computational fluid dynamics modeling hemodynamics measurement microultrasound imaging showed blood velocities great artery aortic arch strong correlations vascular sizes whereas blood pressure weak trend relation vascular size wall shear stress magnitude increased closer arterial branches reduced proximally aortic root distally descending aorta parameters related fluid mechanics branches degree developed method investigate fluid mechanics mouse arteries using combination microultrasound computational fluid dynamics demonstrated ability reveal detailed geometric kinematic fluid mechanics parameters
salient region important part image salient portion images also attracts attention people search images large scale datasets however improve image retrieval accuracy considering salient object image insufficient background also influences accuracy image retrieval address issue paper proposes novel concept called extended salient region esr first salient region input image detected using region contrast algorithm polar coordinate system constructed centroid salient region set pole next regions surrounding salient region determined neighboring regions moving counterclockwise direction resulting combination salient region surrounding regions defined esr extract visual content esr using well known bag words bow model based gabor sift hsvh features propose graph model visual content nodes represent input image design novel algorithm perform matching two images also define new similarity measure combining similarities salient region surrounding regions using weights finally better evaluate image retrieval accuracy improved measure called mean label average precision mlap proposed results experiments three benchmark datasets corel darmstadt caltech demonstrate proposed esr model region matching algorithm highly effective image retrieval achieve accurate query results current state art methods elsevier inc rights reserved
purpose mutations brca genes associated breast ovarian cancer susceptibility recent studies suggested brca mutation might associated occult primary ovarian insufficiency evaluate fertility several studies validated anti mullerian hormone amh direct biomarker ovarian aging considered quantitative marker ovarian reserve hypothesize brca gene mutations negatively associated amh levels methods evaluated women aged years participating northwestern ovarian cancer early detection prevention program patients history cancer ovarian surgery exposure chemotherapy excluded linear logistic regression modeling performed evaluate association amh levels age brca mutation logistic models outcome low amh defined amh years times odds low amh brca still strongly associated low amh conclusion women brca mutation lower amh hence ovarian reserve women without brca mutation therefore young adults brca mutation counseled regarding potential decrease ovarian reserve
analyse presence subclinical atherosclerosis psoriatic arthritis patients psa cross sectional study patients psa controls matched age sex designed carotid intima media thickness imt presence carotid plaques assessed carotid ultrasound data cardiovascular risk factors collected patients psa higher prevalence rate obesity tobacco smoking detected frequently patients psa controls adjusted smoking history disease gave carotid imt significantly higher patients psa adjusted age tobacco smoking according ultrasound data patients psa carotid atherosclerosis presence carotid imt compared controls score index systematic coronary risk evaluation underestimated risk patients patients intermediate risk according carotid ultrasound data psa patients high prevalence subclinical atherosclerosis results support importance screening risk include carotid ultrasound prevention strategies patients
conceptualizing customers organizational citizenship behavior communication cue customer evaluation criterion sales performance facilitator relational selling context authors empirically demonstrate effect salespeople perceptions customers voluntary prosocial behavior three components sales performance authors first hypothesize confirm salespeople perceive customers exhibit organizational citizenship behavior important customer cue serve customer evaluation criterion authors demonstrate salespeople respond perceptions customers organizational citizenship behavior performance enhancing ways results sample business business salespeople suggest customer involved sales performance fully mediates relationship customers organizational citizenship behavior salesperson behavioral performance salesperson behavioral performance partially mediates relationship customer involved sales performance salesperson outcome productivity findings highlight important role customer involved sales performance plays antecedent salesperson individual performance support notion salespeople perceptions interpretations customers organizational citizenship behavior facilitate personal selling augment sales performance implications sales training salesperson evaluation customer evaluation authors discuss implications researchers practitioners elsevier inc rights reserved
analyzing current situation computer programming course presented computational thinking trained program teaching proposed use case teaching program teaching courses well task driven micro lesson moocs advanced teaching philosophy cultivate students computational thinking ability improved students ability computational thinking helpful developing abilities student future
paper presents schematic eye model designed use virtual environments researchers practitioners model based combination several ophthalmic models attempts closely approximate user optical centers intraocular separation using little single measurement pupillary distance typically parameters loosely approximated based user converged known distance however may sufficient users accurately perform spatially sensitive tasks near field investigate possibility comparing impact several common based models schematic eye model users ability accurately match real virtual targets depth done using specially designed display robotic positioning apparatus allowed sub millimeter measurement target positions user responses found schematic eye model resulted significantly improved real virtual matches average accuracy cases well also present novel low cost method accurately measuring using shelf trial frame pinhole filters validated method comparing measurements taken using ophthalmic autorefractor significant differences found two methods
clustering plays important role data mining pattern recognition machine learning single valued neutrosophic sets svnss describe handle indeterminate inconsistent information fuzzy sets intuitionistic fuzzy sets describe deal cluster information represented single valued neutrosophic data paper proposes single valued neutrosophic clustering algorithms based similarity measures svnss firstly introduce similarity measure svnss based min max operators propose another new similarity measure svnss present clustering algorithms based similarity measures svnss clustering analysis single valued neutrosophic data finally illustrative example given demonstrate application effectiveness single valued neutrosophic clustering algorithms
objective investigate prevalence self reported edentulism associated risk factors among community dwelling adults aged years older china materials methods data national baseline survey china health retirement longitudinal study charls used study bivariate multivariate logistic regressions conducted assess predictors edentulism models based whole sample models based subsample anthropometric blood biomarker data available results prevalence edentulism among chinese adults aged shown model older age robust predictor edentulism odds ratio people aged people aged people aged factors positively associated edentulism included female rural residence asthma depression reduced physical function current smoking status people higher educational levels people read write people obtained junior high school education better economic status less likely edentate association edentulism age educational level economic status physical function remained significant model addition underweight appeared another strong predictor conclusions estimated prevalence edentulism identified associated factors provide epidemiologic evidence future research interventions target population china
introduction eating disorders important factor menstrual cycle disorders girls moreover low self esteem among adolescent girls may risk factor eating disorders aim study assess menstrual cycle eating habits self esteem polish adolescents methods study conducted january march included girls aged randomly selected junior high schools silesia poland menstrual cycle risk eating disorders self esteem evaluated five part questionnaire used assess basic demographic data lifestyle physical activity gynecological history well rosenberg self esteem scale ses eating attitude test eat results irregular menstrual cycles observed girls presented secondary amenorrhea based eat test girls indicated risk eating disorder low self esteem observed study girls base ses discussion girls irregular menses higher scores eat test subscales eat overall score eat diet eat bulimia lower scores ses study observe significant relationship exercise intensity body mass bmi menstrual cycle regularity low self esteem among adolescent girls may risk factor eating disorders could interrupt menstrual cycle
purpose study compare analyze effects two instructional methods instructor led simulation based instructions engineering students achievements anti course interests manufacturing engineering class twenty nine undergraduate students participated study anti repeated measures employed collect multiple sets data study showed significant differences means achievement anti interests results discussed conjunction data tables
older people lower socioeconomic status ses disproportionately affected chronic conditions yet less able compensate health limitations use formal long term care ltc home preferred type care like older women single people particularly vulnerable austrian public cash care scheme aims incentivise care home empowerment ltc users study analyses interdependencies ses gender informal family care factors associate use old age formal home care vienna adaptation arber ginn theory used identify material resources income health resources care needs informal caring resources residence availability family care gender aspects also considered persistent source inequalities administrative survey data collected public authorities vienna serve compare home care use old age support forms residential informal care using logistic regression analysis results show pro rich bias home care use among single living people high income single people less likely move care home significant income differences present non singles second traditional gender roles salient female care recipients residing partner likely use formal care men reflecting men traditional gender roles involve less unpaid care work women conclusion urban setting austrian cash care scheme likely reinforce stratifications along gender class thus implementing general policy objective care home likely higher income support mechanism promoting empowerment among older people might contribute unequal degrees choice especially fewer resources manage way fragmented system ltc delivery
children deafblindness need support able understand world access information authors analyzed dyad consisting child congenital deafblindness specialized teacher study included participant observations audiovisual recordings found child showed attention teacher activities involving music rhythm potential forms nonverbal communication child presented vocalization touch body contact body movements facial expressions tears teacher forms communication verbal touch visual rhythm sign language concluded significant communication partner essential identify interpret respond attention communicative behaviors use forms communication must comply individual characteristics child deafblindness receive information environment senses thus guaranteed access world
expansion wireless network technologies emergence novel mobile applications generation communication moving generation communication comparing preceding versions one elementary difference wireless networks operate entirely tcp would cause greater risks terms safety reliability paper new high security architecture long term evolution lte core network server proposed designed asynchronous array simple processors two physically isolated high speed system buses security architecture ensure one bus connected array processors time experiment results show security architecture effectively prevent external threats accessing network resources
evolution concept child abuse leads consider new types maltreatment future certainly taken account new era social pediatrics pediatric care based increased awareness importance meeting psychosocial developmental needs children role families promoting health
spreading depolarizations occur spontaneously frequently injured human brain propagate slowly injured tissue often cycling around local area damage tissue recovery spreading depolarization requires greatly augmented energy utilisation normalise ionic gradients virtually complete loss membrane potential injured brain difficult local blood flow often low unreactive study use new variant microdialysis continuous line microdialysis observe effects spreading depolarizations brain metabolism neurochemical changes dynamic take place timescale passage spreading depolarization past microdialysis probe dialysate potassium levels provide ionic correlate cellular depolarization show clear transient increase dialysate glucose levels reflect balance local tissue glucose supply utilisation show clear transient decrease variable magnitude duration dialysate lactate levels indicate non oxidative metabolism glucose show transient increase preliminary data suggest transient changes recover slowly passage sequence multiple spreading depolarizations giving rise decrease basal dialysate glucose increase basal dialysate potassium lactate levels
open wireless channel dynamic change network topology large energy consumptions hoc networks vulnerable security attacks energy easy run order solve problems paper proposes kind secure energy conservation routing algorithm based trust recommendation trec aodv algorithm decrease energy consumption adjusting transmission radius dynamically detect isolate malicious nodes via new trust recommendation mechanism simulation shows proposed algorithm improve capacity energy conservation robustness networks enhance security networks
architectural project review perception near surrounding ground important evaluation virtual environment near surrounding ground missing using wall screens address problem suggest increasing vertical field view vfov one solution use rendering approach non planar projection however simply increasing fov rendering leads much distortion suitable architectural project review propose new hybrid projection combining perspective projection center screen cylindrical like projection top bottom boarders increase vfov without incurring large deformations preserve perception distances allow seeing surrounding ground also report results experiment conducted evaluate distance perception projection
actions observed everyday life normally consist one person performing sequences goal directed actions present fmri study tested hypotheses observers influenced actor identity even information task irrelevant information shapes expectation subsequent actions actor participants watched short video clips action steps either pertained common action overarching goal performed either one varying actors design independent goal coherence actor coherence elicited activation dorsolateral ventromedial frontal cortex together pointing spontaneous attempt integrate actions performed one actor interestingly watching actor performing unrelated actions elicited additional activation left inferior frontal gyrus suggesting search semantic memory attempt construct overarching goal reconcile disparate action steps coherent intention post experimental surveys indicate processes occur mostly unconsciously findings strongly suggest spontaneous expectation bias toward actor related episodes action observers hence immense impact actor information action observation hum brain mapp wiley periodicals inc
paper present problem specific information based enhanced fireworks algorithm iefwa hybrid iefwa biogeography based optimization bbo algorithm new algorithms tested virtual machine placement problem objective minimizing energy consumption datacenters integer space optimization problem efwa algorithm relatively recent development swarm intelligence based explosion amplitude operator operates continuous space round function used convert explosion amplitude value nearest integer operate integer space iefwa algorithm design domain knowledge placement problem used spark generation iefwa explosion amplitude added information based selected components fireworks instead adding explosion amplitude instead components hybrid iefwa bbo algorithm probabilistically chooses explosion amplitude operator iefwa algorithm migration operator bbo algorithm user determined probability exploitation good candidate solutions placement problem hard existing results demonstrate evolutionary algorithms eas useful choice good quality solution reasonable computing resources experimentally compare performance bbo efwa iefwa hybrid iefwa bbo first fit decreasing ffd algorithms simulation results demonstrate two key findings study first iefwa algorithm consumes less cpu time compared efwa algorithm second iefwa hybrid iefwa bbo algorithms outperform efwa bbo algorithms terms average energy consumed datacenters
background birth weight marker intrauterine environment extensively studied epidemiological research relation subsequent health disease although numerous meta analyses published examining association birth weight subsequent health related outcomes epidemiological credibility associations thoroughly assessed objective study map diverse health outcomes associated birth weight evaluate credibility presence biases reported associations methods umbrella review performed identify systematic reviews meta analyses observational studies investigating association birth weight subsequent health outcomes traits association estimated summary effect size random effects fixed effects models confidence interval prediction interval also assessed study heterogeneity evidence small study effects excess significance bias applied standardized methodological criteria evaluate epidemiological credibility statistically significant associations results thirty nine articles including associations birth weight diverse outcomes met eligibility criteria wide range health outcomes studied ranging anthropometry metabolic diseases cardiovascular diseases cardiovascular risk factors various cancers respiratory diseases allergies musculoskeletal traits perinatal outcomes forty seven associations presented nominally significant summary effect associations remained statistically significant thirty associations presented large large study heterogeneity evidence small study effects excess significance bias present associations respectively one association low birth weight increased risk cause mortality two dose response associations birth weight higher bone mineral concentration hip lower risk mortality cardiovascular diseases per increase birth weight one association small gestational age infants normal birth weight increased risk childhood stunting presented convincing evidence eleven additional associations highly suggestive evidence conclusions range outcomes convincingly associated birth weight might narrower originally described fetal origin hypothesis disease weak evidence birth weight constitutes effective public health intervention marker
appearance media marks audiences participate cultural communication interactions due users attainment media literacy low causing many problems produced information communication media violence extremely obvious means transmission makes violence information communication damage compared traditional media spread larger difficult controlled based reason paper study problem media violence regulatory method put forward
patellofemoral instability defined single multiple episodes patellar dislocation imaging modalities useful characterization patellar malalignment maltracking underlying morphologic abnormalities stabilizing soft tissue injuries using findings orthopedic surgeons decide operate determine best operation measure degree correction postoperatively patients also methods assist diagnosis suspicious cases magnetic resonance imaging preferred method especially setting acute dislocations multidetector computed tomography allows accurate assessment malalignment patellar tilt lateral subluxation secondary osteoarthritis dynamic magnetic resonance imaging dimensional computed tomography introduced better kinematic assessment patellofemoral maltracking extension flexion motions review article discuss currently available evidence regarding conventional novel imaging modalities used diagnosis characterization
albuterol commonly used beta agonist treat reversible lower airway obstruction albuterol contains racemic mixture two enantiomers levalbuterol contains single form enantiomer levalbuterol frequently prescribed limit cardiovascular toxicity examined changes oxygen consumption heart rate following administration albuterol levalbuterol prospective randomized single blinded controlled study healthy adult volunteers subjects separately received albuterol levalbuterol aerosolized min vital signs measured medications min enrolled volunteers median age years compared baseline significant maximum increase following administration albuterol median iqr levalbuterol median iqr significant difference maximum increase following administration albuterol compared levalbuterol compared baseline significant maximal increase albuterol median iqr levalbuterol median iqr statistically significant greater increase maximal following administration albuterol compared levalbuterol albuterol levalbuterol cause significant increase significant difference albuterol levalbuterol regarding maximum increase statistically significant likely clinically insignificant difference maximum increase patients adequate oxygen delivery comparing albuterol levalbuterol
background expect significant relations vitamin receptor vdr gene polymorphism bmd analysis corrected according bone age could explain substantiation biological factors determination young sportsmen training methods examined genotype frequencies allele incidence vdr foki bsmi polymorphisms young athletes boys aged girls aged bmd left hip lumbar spine identified dual ray absorptiometry skeletal maturity according method results identified children genotype heterozygotes homozygotes foki gene polymorphism significant bmd difference found bmd associated gene bsmi distribution bsmi genotypes follows conclusions therefore undisputed results biological medicine examination youth ontogenesis evaluated upon correction according bone age since affects objectivity final assessment children youth
cryptococcus neoformans cryptococcus gattii encapsulated yeasts able cause fatal neurological infections human mammals cryptococcosis common fungal infection central nervous system huge burden sub saharan africa south east asia bird excreta considered environmental reservoir neoformans urban areas therefore study aimed isolating characterizing yeast important disease management study one hundred samples pigeon droppings collected jos plateau state nigeria neoformans isolated three samples initially identified using standard phenotypic biochemical tests molecular analysis revealed three isolates belonged neoformans genotype vnii mating type assigned sequence type multilocus sequence typing analysis study reports first time molecular characterization neoformans nigeria little still known environmental distribution genotypes serotypes mating types important human pathogen elsevier masson sas rights reserved
recent advances programmability performance mobile graphics processing units gpus general purpose graphics processing unit gpgpu technologies become available even mobile devices smartphones tablets among available gpgpu technologies mobile devices open computing language opencl renderscript used accelerate applications various fields computer graphics image processing recognition computer vision example technologies used detecting collisions edges processing data camera recognizing object image processing images stored device accelerating drawing image live wallpaper used android based devices technologies increase processing speed well reduce power consumption mobile devices addition general applications great potential use optimizing algorithms scientific fields paper describes gpgpu technologies mobile devices compares similarities differences compares performance research purposes best knowledge paper first work compares analyzes available gpgpu technologies mobile devices
using data national longitudinal study adolescent health add health study expands previous research examining differences across race patterns subgroups adolescents based nine self reported behaviors delinquency substance use risky sexual practices comparing risk factors peer association parenting neighborhood cohesion within across race specific subgroups related membership identified latent classes data used study include respondents aged participated waves add health home interview latent class analysis lca identified key differences number characteristics latent classes across racial subgroups addition similarities differences risk factors membership latent classes identified across within race specific subgroups implications understanding risky behavior adolescence well directions future research discussed
due life enhancing effects antiretroviral therapy hiv positive persons potential long life comparable uninfected peers older women age living hiv owlh often recognized aging group conducted systematic review examine psychosocial factors impact owlh live cope age hiv initial key word search yielded records studies met inclusion criteria original quantitative qualitative research published results specific owlh focused health care self management sexual health risk stigma loneliness mental health depression substance use protective factors coping social support well due scarcity studies topic inconclusive findings clear patterns results emerged number owlh continues grow research including longitudinal studies needed fully characterize psychosocial factors impact aging hiv
background current therapies osteoporosis focus reducing bone resorption development therapies regenerate bone may also beneficial promising anabolic therapy candidates include phytoestrogens daidzein effectively induce osteogenesis adipose derived stromal cells ascs bone marrow stromal cells bmscs purpose investigate effects glyceollins structural derivatives daidzein osteogenesis ascs bmscs study design herein osteoinductive effects glyceollin glyceollin assessed compared estradiol ascs bmscs mechanism glyceollin induces osteogenesis examined methods ability glyceollins promote osteogenesis ascs bmscs evaluated adherent scaffold cultures relative deposition calcium analyzed using alizarin red staining bichinchoninic acid protein assay alamar blue assay explore mechanism glyceollin exerts osteoinductive effects docking studies glyceollin rna isolation cdna synthesis quantitative pcr qpcr performed results adherent cultures ascs bmscs treated estradiol glyceollin glyceollin demonstrated increased calcium deposition relative vehicle treated cells evaluation plga scaffolds seeded ascs bmscs glyceollin efficacious inducing asc bmsc osteogenesis compared estradiol glyceollin dose response analysis ascs bmscs revealed glyceollin highest potency adherent cultures tissue scaffold cultures doses osteoinductive effects attenuated fulvestrant suggesting glyceollin acts least part estrogen receptor mediated pathways induce osteogenesis analysis gene expression demonstrated similar estradiol glyceollin induces upregulation genes involved osteogenic differentiation conclusion ability glyceollin induce osteogenic differentiation ascs bmscs indicates glyceollins hold potential development pharmacological interventions improve clinical outcomes patients osteoporosis elsevier gmbh rights reserved
background female sex workers fsws increased risk hiv stis compared women general population frequently experience violence working domestic lives variety perpetrators enhance risk progress made addressing violence police clients little work done understand prevent violence intimate partners ips among fsw populations methods samvedana plus multi level intervention programme works fsws ips sex worker community general population aims reduce violence increase consistent condom use within intimate relationships programme involves shifting norms around acceptability beating form discipline challenging gender roles give men authority women working men women encourage new relationship models based gender equity respect programme aim cover fsws ips living villages bagalkot district northern karnataka study designed assess two primary outcomes proportion fsws report physical sexual partner violence consistent condom use intimate relationship within past months evaluation employ cluster randomised controlled trial design village clusters randomly selected receive intervention first months remaining receiving intervention thereafter statisticians blinded treatment arm allocation evaluation use adjusted cluster level intention treat analysis comparing outcomes intervention control villages midline months endline months evaluation design involve quantitative qualitative assessments fsws report ips process implementation monitoring baseline data collection completed april endline data collection anticipated may conclusions innovative intervention programme aims address violence ips part hiv prevention programming fsws reducing violence expected reduce vulnerability hiv acquisition help women work live without fear violence trial registration clinical trials nct jun retrospectively registered
cryptography important role data security known attacks decreases limits risks hacking information especially rapid growth communication techniques recent years noticed increasing requirement implement cryptographic algorithms fast rising high speed network applications paper present high throughput efficient hardware implementations advanced encryption standard aes cryptographic algorithm adopted pipeline technique order increase speed maximum operating frequency therefore registers inserted optimal placements furthermore proposed stage pipeline box design using combinational logic reach speed addition efficient key expansion architecture suitable proposed design also presented order secure hardware implementation side channel attacks masked box introduced implementations successfully done virtex xcvlxt field programmable gate array fpga device using xilinx ise proposed unmasked masked architectures fast achieve throughput gbps gbps respectively obtained results competitive comparison implementations reported literature
paper presents application knowledge based software architecture kbsa scheme developed implemented order used tool electrical machines design industrial process proposed scheme layers introduced considering several impact factors many points view technical material algorithmic economic etc well interference evident specific engineering design problem poses inherent demand knowledge representation framework could support entire life cycle requirements specification coding well software process context work continues presenting design results implemented kbsa certain type permanent magnet motor currently research electric vehicle industry wheel electric vehicle application kbsa employs evolutionary algorithms systematic optimization results reveal effectiveness aforementioned procedure followed
bit digital controlled switch type passive phase shifter realised digital cmos technology without ultra thick metals ghz industrial scientific medical ism band presented patterned shielding electromagnetic bandgap structure stacked metals method increase chip inductor quality factor proposed reduce insertion loss transistors transistor switches implemented body source connection states minimum phase error degrees maximum phase error degrees measured insertion loss including pad loss ghz return loss ghz total chip size power consumption
objective evaluate relationships among modifiable psychological factors chronic migraine severe migraine related disability clinic based sample persons migraine background evidence evaluating relationships modifiable psychological factors chronic migraine severe migraine related disability lacking people migraine presenting routine clinical care methods adults migraine completed surveys routinely scheduled visits tertiary headache center participants completed surveys assessing chronic migraine meeting criteria migraine headache days past month severe migraine disability migraine disability assessment scale score modifiable psychological factors depressive symptoms patient health questionnaire anxious symptoms generalized anxiety disorder pain catastrophizing scale headache specific locus control logistic regression evaluated relationships modifiable psychological factors chronic migraine severe migraine disability results among eligible participants mean age women one third met study criteria chronic migraine half participants reported severe migraine related disability higher depressive symptoms chance hslc associated chronic migraine higher depressive symptoms anxiety symptoms pain catastrophizing associated severe migraine related disability conclusions psychiatric symptoms pain catastrophizing strongly associated severe migraine related disability depression chance locus control associated chronic migraine study supports need longitudinal observational studies evaluate relationships among naturalistic variation psychological factors migraine related disability migraine chronification
ankyrin ank implicated genetic risk factor bipolar disorder however resulting pathophysiological treatment implications remain elusive preclinical systems biological approach aimed characterize behavioral proteomic effects ank haploinsufficiency chronic mood stabilizer treatment mice psychiatric related behavior evaluated novelty suppressed feeding nsf paradigm elevated plus maze epm passive avoidance task pat tandem mass spectrometry mse employed hippocampal proteome profiling functional enrichment approach based protein protein interactions ppis performed outline biological processes hippocampus affected ank haploinsufficiency lithium treatment proteomic abundance changes detected mse highlighted ppi network modelling followed targeted selected reaction monitoring srm increased psychiatric related behavior ank mice ameliorated lithium assessments nsf epm pat mse followed modular ppi clustering functional annotation enrichment pointed towards kinesin related axonal transport glutamate signaling mediators ank pathophysiology lithium treatment srm validated hypothesis confirmed abundance changes ank interaction partners propose psychiatric related behavior ank mice connected disturbance kinesin cargo system resulting dysfunction neuronal ion channel glutamate receptor transport lithium reverses molecular signature suggesting promotion anterograde kinesin transport part mechanism action ameliorating ank related psychiatric related behavior elsevier ecnp rights reserved
land use land cover change lulcc one main components current anthropogenic global change unravelling ecological response biodiversity combined effect land use change stressors essential effective conservation purpose used inertia analysis combine lulcc analysis earth observation satellite data derived maps raptor data obtained road censuses conducted sampling unit level spatial resolution northwestern spain province ourense addition habitat suitability models also computed using ten widely used single modelling techniques providing ensemble predictions landscape level four spatial resolutions radius around sighting year raptor species analyse habitat suitability changes whole study area three niche overlap indices models revealed increase occurrence habitat suitability forest raptor species coupled strong decrease species associated open habitats mainly heaths shrub formations open habitat specialist species negatively affected concomitant effects intensive forest management long lasting trend rural abandonment coupled unusually high frequency wildfires sustainable forest management agricultural practices encouraged public private sectors policies related european funds rural regional development feder feader programs effectively protect threatened habitats species comply current environmental legislation combined use satellite imagery ground level biodiversity data proved cost effective systematic method monitoring priority habitats species highly dynamic landscapes
state art building automation systems energy efficient sustainable recently bac revealed potential increasing energy efficiency buildings system certification independent manufacturer energy performance buildings directive epbd adopted revised important step towards improvement energy efficiency large stock existing buildings europe result forty standards developed aim harmonizing methods calculating energy consumption buildings europe shows building automation used minimise energy consumption new bac system methodology assesses building automation based auditing building automation system represents ideal basis optimising installation called continuous commissioning supports building automation manufactures services recognised standards leads sustainable operation maintenance building value life time european building automation controls association bac founded comprises manufacturers providers objectives promote building automation ensure product quality actively support cen iso standardisation european directives elsevier rights reserved
analyse people attitudes robots used caring elderly using eurobarometer data relating november december approximately people country given constraints public expenditure one solution meeting increased obligations area people tend lukewarm robotic care elderly however simple average hides fact many people young old totally hostile concept smaller number totally favour consistent literature find young favour option elderly differences males cities educated favour well differences countries thus three french speaking countries relatively little evidence differences attitudes young old differences different groups people found widen age represents new finding literature
aims lipoprotein well established risk factor coronary artery diseases cad would also anticipated associated similar manner risk type diabetes mellitus tdm based common soil hypothesis etiology tdm cad unfortunately remains considerable uncertainty regarding association risk tdm aimed examine association tdm methods cross sectional study cases controls performed identifying association tdm possible interactions risk factors threshold effects tdm association cad also examined compared within study results continuous scale higher levels insignificantly associated fully adjusted tdm categorical scale fully adjusted ors tdm decile reference decile magnitude association increase increasing decile trend test contrast higher levels significantly associated prevalent cad continuous categorical scale fully adjusted model threshold effects observed terms association tdm cad conclusions current study suggested lack association levels prevalent tdm contrast levels significantly associated cad dose responding manner findings provided evidence differential approaches higher levels patients tdm cad
purpose adrenal venous sampling generally considered gold standard identify unilateral hormone production cases primary hyperaldosteronism aim study evaluate whether iodine beta iodomethyl norcholesterol test may represent alternative selected cases methods patients submitted laparoscopic adrenalectomy suspected primary hyperaldosteronism retrospectively reviewed nuclear medicine tests preoperatively performed results compared histopathologic findings clinical improvement results nuclear medicine tests realized patients planar anterior posterior scintigraphy performed spect two scintigraphy indicated preoperative lateralization patients value tests based pathologic results showed sensitivity positive predictive value nuclear medicine test performance based postoperative blood pressure control sensitivity positive predictive value conclusions nuclear medicine tests represent useful tool preoperative localisation primary hyperaldosteronism high sensitivity positive predictive value patients contraindications adrenal venous sampling like contrast allergies inconclusive scintigraphy represent useful non invasive alternative
paper proposes new solution health system architecture related personal assistance home aged people architecture takes account results two ongoing projects authors involved sweet home amihomecare possibility combining different parts projects order obtain versatile system project distinctive way gathering required information sweet home uses sound processing amihomecare video processing paper analyzes advantages drawbacks approaches order propose integrative new architecture
human memory imperfect process prone distortion errors range minor disturbances major errors serious consequences everyday life study investigated false remembering manipulatory verbs using explicit recognition task pupillometry results replicated classical pupil old new effect well data false remembering literature show items must recognize old order pupil size increase subjective pupil old new effect even though items necessarily truly old findings support strength memory trace account affirms pupil dilation related experience rather accuracy recognition moreover behavioral results showed higher rates true false recognitions manipulatory verbs consequent larger pupil diameter supporting embodied view language elsevier rights reserved
last quarter century epidemic overweight obese americans increased strikingly turn caused substantial rise risk cardiovascular diseases cholesterol hypertension osteoarthritis stroke type diabetes specific forms cancer diseases main purpose research investigate influence gardening activities activity levels body mass index bmi allergies reported overall health gardeners nongardeners sample population drawn two sources online survey identical paper pencil formatted survey distributed church garden community service groups within texas parts mid western united states total people participated study results study indicated nongardeners less physically active compared gardeners however frequency gardening statistically significant impact gardeners bmi also difference bmi gardeners nongardeners gardeners indicated frequently reoccurring symptoms ear infection ear ache high cholesterol kidney stone gallstones arthritis indicating gardening may used distraction therapy helping gardeners cope pain remain active forms exercise may option statistically significant difference incidence allergies gardeners nongardeners
background serum vitamin levels reported associated individual components body composition however relationship serum vitamin combined indices adverse body composition largely unknown cross sectional study examined association serum vitamin osteosarcopenic obesity nationally representative sample middle aged older adults methods analysed korea national health nutrition examination surveys conducted consisting men women aged years serum vitamin levels determined radioimmunoassay body composition evaluated dual energy ray absorptiometry association serum vitamin levels number abnormalities body composition including osteosarcopenic obesity low bone muscle mass concurrent high fat mass analysed multinomial logistic regression adjusting covariates results men controlling covariates higher vitamin levels associated significantly reduced likelihood number phenotypes adverse body composition trend highest tertile group serum vitamin levels compared lowest tertile less likely adverse body composition numbering one odds ratio confidence interval two three osteosarcopenic obesity women highest tertile group serum vitamin levels compared lowest tertile less likely osteosarcopenic obesity vitamin deficiency men significantly associated increased likelihood higher number adverse body composition especially osteosarcopenic obesity vitamin deficient women compared normal levels serum vitamin also likely demonstrate osteosarcopenic obesity conclusions high serum vitamin level mid late life associated reduced odds multiple adverse body composition especially osteosarcopenic obesity suggesting potential health benefits maintaining adequate levels vitamin
cognitive remediation therapy crt intervention anorexia nervosa focuses ameliorating neuropsychological inefficiencies underlie illness current literature reported promising results regarding efficacy intervention however scarcity studies considering implementation crt child adolescent population article describes individual crt therapy programme children adolescents delivered inpatient unit eating disorders considers therapeutic process including differing viewpoints patients therapists article concludes crt viewed engaging therapeutic intervention could useful additional treatment
endocannabinoid signaling plays critical role mediating rewarding effects morphine relative stability expression reinstatement morphine conditioned place preference cpp suggests involvement differential neuroadaptations learned associations environmental cues morphine changes gene expression hippocampus endogenous cannabinoid system ecb may accompany mediate development neuroadaptations repeated morphine stimulation test possibility systematically compared expression ecb related genes dorsal hippocampus following expression extinction reinstatement morphine cpp using quantitative pcr analyses found expression morphine cpp associated significant increases mrna expression primary clearance routes anandamide aea fatty acid amide hydrolase faah monoacylglycerol lipase magl respectively reductions cannabinoid receptors cbr cbr dorsal hippocampus following expression cpp however results indicated decreased magl increased cbr mrna levels accompanied morphine cpp reinstatement significant changes mrna expression enzymes involved aea biosynthesis acylphosphatidylethanolamine phospholipase napepld diacylglycerol lipase alpha beta daglet respectively found conditions results suggest differential regulation synthesis degradation ecb system contribute expression reinstatement morphine cpp elsevier rights reserved
background meet aims providing comprehensive coordinated care patient centered medical homes pcmhs need coordinate services individuals substance use disorders yet addiction treatment organizations across united states provide services million individuals daily generally ill prepared work pcmhs organizations often lack electronic health records objectives examine extent organizations formal linkages contracts pcmhs identify key dimensions linkages pcmhs organizations shared use electronic health records identify characteristics organizations environments associated linkages materials methods draw data nationally representative survey directors clinical supervisors organizations survey respondents results thirty eight percent patients across nation receiving treatment organizations linked contracts pcmhs number increases states expanded medicaid patients non medicaid expansion states yet great majority linkages relatively weak include exchange patient information results multivariable analyses show larger nonprofit publicly owned organizations well located northeast states expanded medicaid coverage likely contracts pcmhs conclusions without stronger linkages organizations pcmhs development models integrate services individuals substance abuse disorders may continue receive uncoordinated care
chronicles analyzed paper repot poetic language realities women regarding issues related gender associated roles sex plays society paper aims identifying issues related construction gender roles three proses written eduardo galeano cultura terror historia outro charlotte last receives emphasis since charlotte main character considers questions values govern society methodology used qualitative paradigm constructed bibliographical research theoretical framework used authors louro foucaul galeano telles among others analysis noticed literature case chronicle written prose great acceptance among readers concepts identified reflected contributing new presentation reality modified construction thinking
background develop singapore chinese english versions psoriatic arthritis quality life psaqol scale equivalent met psychometric acceptability standards original measure methods translation original psaqol contextualised english chinese versions use singapore performed professional lay translation panels ten chinese speaking ten english speaking local patients interviewed assess face content validity psoriatic arthritis psa patients either chinese english speaking fulfilling classification criteria psoriatic arthritis invited participate validation survey clinical variables health assessment questionnaire haq medical outcome short form used comparator instruments convergent validity separate sample psa patients invited participate test retest postal study two weeks administrations results validation sample included patients men mean age years psaqol excellent internal consistency cronbach scores measure moderately correlated health status measures pain haq score scores patient physician global assessments scale able distinguish groups active inactive disease assessed composite scores haq minimal disease activity test retest reliability excellent conclusions study provides evidence adapted english chinese versions psaqol used clinical studies psa patients singapore
carbon fiber reinforced polymers cfrps attracted attention aerospace industry due light weight excellent mechanical properties resistance corrosion however cfrp composites difficult recycle recycling process must performed extreme conditions end life regulations directly address problem reusing composites thus objective study explore solutions minimize use cfrps prolong useful life airline industry achieve goal work conducted review state art cfrp fiber recycling emphasizing recycling processes restrictions regulations one solution develop cfrp recycling market would allow sequential use recycled materials among industries descending order required structural performance composite
innovation scholars long recognized entrepreneurship imitative whereas commercialization novelty innovative thus highly distinctive skill sets entrepreneurship first involves optimizing market sentiment pure profit sometimes point catastrophe even fraudulence many markets include payment protection insurance ppi flash crashes automotive emission defeat devices corporate bribery settlements social media hacking fake news litany infractions catastrophes innovation contrast explorative team reliant even patenting betrays hope commercialization markets patented innovation frequently fails academic innovators even profess preference prizes profits second means collective bonding among entrepreneurs form claimed entrepreneurial ecosystems often based single customer platform supplier highly specialist type imitative service identikit pizza chains smartphone apps latter fused artificial intelligence interactive machine learning services long existed postsocial algorithms serving customers example investment banks stock currency markets finally entrepreneurship fundamentally competitive individualistic non solidaristic whereas open innovation born practices open science collegiate tradition research accordingly entrepreneurial ecosystems display closure ris set ups special issue explores aspects ecosystem platforms implications emergent forms urban regional evolution near nearly present future
emergence electric aircraft needs adapt electrical architecture level power generation storage paper deals optimal sizing battery supercapacitor systems match energetic performances aircraft requirements application global weight minimized acting variables cut frequency filter used energy management discharge ratio storage components temperature optimization results obtained simulated annealing method assessed whole temperature range finally relation cut frequency temperature determined adjust board energy management
fittings called start connectors usually employed attach lateral corresponding manifold microirrigation systems protrusion start connectors barbs manifold induces pressure losses due contraction subsequent enlargement streamlines addition water flows manifold toward lateral start connector sudden contraction followed expansions flow streamlines cause pressure loss whose intensity influenced connector geometry minor losses along manifolds laterals inlet due start connectors may significant might considered subunits design undertaking hydraulic simulations objectives research develop equations based dimensional analysis estimate minor losses due start connectors compare accuracy developed models models currently used estimating minor losses undertake simulations assess relevance minor losses due start connectors hydraulics subunits minor losses due start connectors separated two components model developed validated estimate minor losses due protrusion start connectors inserted along manifold two models developed validated estimate minor losses occur water flows manifold lateral line start connector required data develop validate models obtained experimentally laboratory although minor losses due start connectors represented relative small percentage total head losses effects may significant undertaking rigorous hydraulic simulations require accurate estimation pressure losses
among uncertain graph queries reachability probability one vertex reachable another likely fundamental one although problem studied within field network reliability solutions implemented single computer handle small graphs however size graph applications continually increases corresponding graph data longer fit within single computer memory must therefore distributed across several machines furthermore computation probabilistic reachability queries complete making expensive even small graphs paper develop efficient distributed strategy called distr solve problem reachability query large uncertain graphs specifically perform task two steps distributed graph reduction distributed consolidation distributed graph reduction step find maximal subgraphs original graph whose reachability probabilities calculated polynomial time compute reduce graph accordingly step small graph remains distributed consolidation step transform problem relational join process provide approximate answer complete reachability query extensive experimental studies show distributed approach efficient terms computational communication costs high accuracy
technique system simulation gained wide acceptability last three decades become important tool modern decision making science main reason fast development branch decision science rapid growth digital computers present system simulation finds important place manufacturing engineering extensively employed aid analysis optimization manufacturing systems design new production facilities layout generation warehouses distribution systems evaluating selecting software packages meet organization requirements difficult decision making process selection wrong software package turn costly adversely affect business processes aim paper provide basis improve process evaluation selection software packages variety simulation tools manufacturing system current research focus study overview available simulation software attempt made build criteria selecting simulation software manufacturing system current approach appropriately applied result effective simulation software selection application
recent times moocs become technology enabled platform allows delivery content locations geographically separated birla institute technology science bits pilani edx platform successfully used deliver content multiple campuses namely pilani campus goa campus hyderabad campus present paper challenges faced implementing pedagogy solutions attempted tools required make learning computer programming course better experience particular described handled bits pilani hyderabad campus
learning teaching computer programming acknowledged difficult challenging metacognitive learning environment needed learning success computer programming problem solving designing support learning tool main principal instructional approach support metacognitive ability ontology gained popularity building learning formalism ontology based description achieved thus giving specification domain scope offering effective reuse software patterns systems patterns exact methodology developing ontologies paper present approach development mssnp ontology based general criteria issues considered
sugars stereochemically intricate family biomolecules present substantial challenges anyone trying understand nomenclature reactions branched structures current crystallographic programs provide abstraction layer allowing inexpert structural biologists build complete protein nucleic acid model components automatically either scratch little manual intervention however still generally true sugars need carbohydrate specific building validation tools highlighted number times past concomitantly introduction new generation experimental methods ramping production protein sugar complexes glycoproteins past decade incipient advances made address demands correctly modelling refining carbohydrates remains challenge article address many typical difficulties structural biologist may face dealing carbohydrates emphasis problem solving resolution range ray crystallography cryo electron microscopy expected overlap next decade
many garners report playing video games including violent content helps reduce stress however studies examined competitive cooperative video game play relate stress reduction current study employed design acutely stress participants assigning randomly play mildly violent game either competitively cooperatively female confederate results indicated stress levels declined time equal levels competitive cooperative game play participants competitive condition held slightly less positive impression confederate following game play although players held generally positive impression confederate overall elsevier ltd rights reserved
nosql databases rapidly becoming customary data platform big data applications databases emerging gateway alternative approaches outside traditional relational databases characterized efficient horizontal scalability schema less approach data modeling high performance data access limited querying capabilities lack transactional semantics among nosql databases made choice particular consistency model dependent application therefore essential examine methodically detail performance various databases diverse workload conditions three commonly used nosql databases mongodb cassandra hbase evaluated using yahoo cloud service benchmark popular benchmark tool horizontal scalability three systems different workload conditions varying dataset sizes captured benchmark suite summarizes results evaluation presented
efficient power management smart grids requires obtaining power consumption data resident however data concerning user electricity consumption might reveal sensitive information living habits lifestyles order solve problem paper proposes privacy preserving cube data aggregation scheme electricity consumption scheme data item described multi dimensional data structure dimensional users form live multiple residential areas areas users area based horner rule user construct user level polynomial store dimensional values single data space using first horner parameter embedding second horner parameter polynomial polynomial hidden using paillier cryptosystem aggregating data areas hide area level polynomial final output moreover propose batch verification scheme multi dimensional data reduce authentication cost finally analysis shows proposed scheme efficient terms computation communication costs suitable massive user groups supports flexible rapid growth residential scales smart grids
backgroundadapted parenting support may alleviate high levels parenting stress experienced many parents intellectual disabilities methodsparents mild intellectual disabilities borderline intellectual functioning randomized experimental control conditions parents groups received care usual experimental group also received adapted version video feedback intervention positive parenting learning difficulties vipp measures parenting stress obtained pre test post test month follow resultsrandomization experimental group ledto steeper decline parenting stress related child compared control group nostatistically significant effect stress related tothe parent functioning situation found conclusionsthe results study suggest feasibility reducing parenting stress parents mild intellectual disability mid parenting support possible benefit children
background aimsthe aim study compare acoustic radiation force impulse arfi elastography noninvasive tests develop new score assessment liver fibrosis cirrhosis materials methodsb mode ultrasound including high frequency liver surface evaluation routine blood tests arfi quantification mini laparoscopic liver evaluation obtained compensated patients scheduled mini laparoscopic biopsy new cirrhosis score assessment liver cirrhosis based linear combination arfi platelet plt liver surface prothrombin index calculated linear discriminant analysis performance compared arfi elastography apri fib alanine aminotransferase alt aspartate aminotransferase ast ratio plt diagnosis cirrhosis combined gold standard cirrhosis histology macroscopic liver evaluation used resultsin total patients compensated cirrhosis included significantly better diagnosis cirrhosis compared arfi apri plts alt ast ratio fib score area receiver operating characteristic curve confidence interval respectively sensitivity specificity positive predictive value negative predictive value respectively fib score significantly superior apri score alt ast ratio significant difference arfi elastography diagnosis cirrhosis conclusioncombining arfi elastography noninvasive tests used routinely workup patients suspected liver disease improve diagnostic accuracy compensated liver cirrhosis compared arfi elastography alone fib score showed overall comparable diagnostic accuracy arfi elastography compensated cirrhosis copyright wolters kluwer health inc rights reserved
recently several articles cullmann agrell filippini orea llorca address issue benchmarking decision making units different technologies using latent class models method groups units similar technology better comparison scheme two implicit assumptions first class reflects unique technology elements outliers second classes assumed stationary fixed assumption violated classification transient time dependent inadequate regulatory use suggested seminal papers apply latent class models classify swedish electricity distributors different specifications models identify one large class approximately dmu two small classes respectively moreover small classes elements switch categories contrast parametric results nonparametric outlier detector methods find relationship identified outliers elements smaller residual classes believe work important caveat adoption latent class modelling alternative remedy conventional models relying homogeneous reference set
desktop grid systems distributed computing paradigms use idle underutilized processing cycles memory desktop machines hosts support large scale computations systems inherent uncertainties hosts work one administrative domain become unavailable given point time desktop grid frameworks based client server model employ various scheduling policies ends handle hostile desktop grid environment server end task scheduling policies deployed whereas work fetch cpu scheduling policies implemented client end task scheduling policy decides job send client depending upon client task preferences work fetch policy determines client ask work server cpu scheduling policy selects job execution jobs available client policy works top local operating system scheduler paper evaluated impact cpu scheduling policies application performance using boinc client boinc client emulator bce analyzed two widely used cpu scheduling mechanisms using four scenarios five performance measures found early deadline first edf works better compared traditional round robin mechanism cases
medial opening wedge high tibial osteotomy mowhto surgical procedure treat knee osteoarthritis associated varus deformity however ideal final alignment hip knee ankle hka angle frontal plane maximizes procedural success post operative knee function remains controversial therefore purpose study introduce subject specific modeling procedure determining biomechanical effects mowhto alignment tibiofemoral cartilage stress distribution finite element knee model derived magnetic resonance imaging healthy participant manipulated silico simulate range final hka angles degrees degrees degrees degrees valgus loading boundary conditions assigned based subject specific kinematic kinetic data gait analysis multiobjective optimization used identify final alignment balanced compressive shear forces medial lateral knee compartments peak stresses decreased medial increased lateral compartment hka shifted valgus balanced loading occurring angles degrees degrees valgus femoral tibial cartilage respectively concept introduced provides platform non invasive patient specific preoperative planning osteotomy medial compartment knee osteoarthritis ipem published elsevier ltd rights reserved
one third cancer patients undergoing chemotherapy treatment often display symptoms depression leading poor adherence decreased quality life thus study aimed investigate possible protective effect nebivolol cisplatin associated depressive symptoms adult male rats nebivolol highly cardioselective adrenergic receptor blocker possesses endothelium dependent vasodilator properties antioxidant capacities animals allocated four groups group one given aqueous solution carboxymethyl cellulose served control group two given nebivolol daily group three given cisplatin per week consecutive weeks group four treated cisplatin concomitantly nebivolol per schedule cisplatin treated rats showed increase depressive like behaviors open field forced swimming tests addition histopathological examination revealed cortical encephalomalacia along hippocampal neuronal degeneration kidney dysfunction parallel cisplatin administration prominently reduced gaba elevated glutamate levels cortical hippocampal tissues furthermore resulted significant decline cortical hippocampal brain derived neurotrophic factor nitric oxide contents concomitantly marked decrease endothelial increase inducible nitric oxide synthase genes expression hand treatment nebivolol effectively mitigated aforementioned cisplatin associated behavioral biochemical histopathological alterations without changing antitumor activity evidenced sulforhodamine cell survival assay taken together results suggest nebivolol may offer promising approach alleviating depressive symptoms associated use cisplatin
although managing fairness critical concern organizations managers predisposed enact high levels fairness emerging empirical evidence suggests personality characteristics important antecedent managers fair behavior however relatively little attention devoted understand promote fairness among managers naturally predisposed engage lower levels fairness building upon self awareness theory argue increasing managers self awareness motivate managers low trait empathy engage greater levels justice test interactive effects trait empathy state self awareness using experimental study individuals asked communicate negative news support hypothesis results indicate increasing self awareness self focusing situations help promote interactional justice communicating negative news individuals low trait empathy theoretical practical implications findings discussed
objectives patients substance use disorders general opiate use particular may suffer different eating problems higher prevalence eating disorders evident patients opiate use disorders general population materials methods three groups aged years male participants group included study participants group opioiddependent patients week abstinence substance group included patients opioid dependence completion days detoxification participants third group consisted volunteers substance use disorders members patient groups diagnosed according dsm tested using addiction severity index groups tested using eating attitudes test eat results group highest dieting scale score eat followed group group difference regard bulimia food preoccupation scale score groups studied group highest oral control scale score followed group group total eat score patients current opioid dependence highest scores tramadol daily dose correlated positively bulimia scale oral control scale total eat patients groups together respectively conclusions eating patterns among patients opioid dependence different patients recovery normal population
debris flows occurred hill slopes gullies indicated single channel watersheds indicated tributaries channels july loth wenchuan county caused casualties usd losses work aimed analyze characteristics hazards causes events explore mitigating measures based field investigation remote sensing images interpretation debris flows contained clay content similar densities similar velocities similar discharges similar sediment yields similar also numerously occurred large watersheds area large debris flows formed hazard chains slopes gullies watersheds rivers evolved dammed lakes outburst flood dammed lakes newly ones generated along rivers min yuzi remarkable spatial difference loose solid materials accumulation intense rainfall cumulative hourly caused debris flows sections yingxiu miansi gengda damages buildings reconstructions highways factories hydro power station originated impacting scouring burying debris flows submerging dammed lake scouring outburst flood huge losses came ruinous destructions control engineering works debris flows well irrational location low resistant capabilities reconstructions hazards mitigating debris flows long term feasible measures short term including risk reassessing foregone potential hazard sites regional alarming system establishing integrated control disastrous sites middle long term including improving reconstruction standard rationally disposing river channel bed rise selecting appropriate reconstruction time plans strongly suggested
paper presents new topologies emulating floating immittance functions using three five passive elements two current feedback operational amplifiers cfoas feasibility using two cfoas two passive components explored proposed topologies emulate lossy positive negative inductances capacitance inductance resistance multipliers frequency dependent negative positive conductances functionality proposed circuits experimentally verified using commercially available cfoa experimental results excellent agreement theoretical calculations
number smart devices around grows every day need interface order share data activate functions day new scenarios new applications emerge make lives easier many different contexts race towards realizing true internet things iot paradigm already begun reality hand work presented herein aims offer practicable scalable solution fulfilling many promises internet things even contexts rendered problematic continuing presence closed proprietary systems lacking compatibility internet protocols home automation industry starting major contribution laboratory field interoperability among natively incompatible domotic technologies software module developed enable home automation devices interface interact via ipv network protocol every home automation device thereby interact actively surrounding world made reachable ipv address identifies uniquely internet proposed system thereby advances users ability take full advantage benefits offered new iot vision world
rsa cryptosystem elliptic curve cryptography ecc used practically widely public key cryptography security rsa ecc respectively relies computational hardness integer factorization problem ifp elliptic curve discrete logarithm problem ecdlp paper give estimate computing power required solve problem state art theory experiments comparing computing power required solve ifp ecdlp also estimate bit sizes two problems provide security level
first study years war activities report content heavy metals metalloids polycyclic aromatic hydrocarbons pahs polychlorinated biphenyls pcbs found samples soils selected playgrounds sarajevo due fact children direct contact surface soils recommended children playgrounds given special consideration respect basic properties mol kcl humus caco examined soils determined samples determination heavy metals metalloids prepared microwave assisted acid digestion determined using inductively coupled plasma optical emission spectrometer fluorine determined potentiometrically gas chromatography mass spectrometry used determination pahs pcbs determined contents ranges respectively total pahs ranged total pcbs preliminary results may contribute accurate health risk assessments soils may included projects planning children health risk assessments adopting environmental legislation sufficiently regulated bosnia herzegovina far
paper extension previous one presented conference cyberworlds work addressed problem fit given set data points least square sense using polynomial bezier curve problem arises many scientific industrial domains numerical analysis statistical regression computer aided design manufacturing computer graphics virtual reality etc critical issue address least squares minimization problem curve parameterization previous work solve applying powerful nature inspired optimization method called bat algorithm although obtained pretty good results number examples method still improved considering memetic approach global search bat algorithm hybridized local search procedure enhance exploitation phase minimization process paper extend previous method two local search strategies luus jaakola assrs cases adaptive self adaptive versions considered leading four memetic schemes comparative analysis results previous benchmark four memetic schemes previous method carried shows memetic approaches improve efficiency previous method different extent instances benchmark
psoriasis chronic relapsing autoimmune disorder skin affecting general population approximately psoriasis patients also affected psoriatic arthritis chronic inflammatory spondyloarthritis review aims present current knowledge immunopathogenesis diseases emphasize involvement various helper cell subsets extensive literature search electronic databases performed topic different cell subsets involvement pathogenesis psoriasis psoriatic arthritis studies assessed selected present recent progress area current data strongly suggest pso psa cell mediated diseases key role various proinflammatory cytokines development involvement cells highlighted superior efficacy biologic therapies targeting cell derived proinflammatory cytokines diseases initially pso psa thought mediated diseases however last years several studies shown important role cell subsets including treg cells pathogenesis diseases led development new therapies
backgroundpavlovian instrumental transfer pit examines effects associative learning upon instrumental responding previous studies examining pit ethanol etoh maintained responding showed increases responding following presentation etoh paired conditioned stimulus recently conducted studies examining pit etoh paired one found increases responding less robust demonstration pit may resulted form used used second light stimulus previous studies used either second auditory stimulus second light stimulus study examined whether using conditions similar earlier study either second auditory second light stimulus resulted robust pit also examined reliability previous failure observe pit methodsthree experiments conducted examining whether pit obtained using second light stimulus second light stimulus iii second auditory stimulus css resultswe found pit obtained using second light stimulus second light stimulus iii second auditory stimulus conclusionsthese results suggest form account earlier failure see pit rather factors like rat strain etoh drinking induced may account pit observed
autism spectrum disorder diagnoses sometimes change due misdiagnosis maturation treatment study uses probability based national surveythe survey pathways diagnosis servicesto compare currently diagnosed previously diagnosed children aged years based retrospective parental reports early concerns children development responses concerns doctors healthcare providers type provider made first autism spectrum disorder diagnosis autism spectrum disorder subtype diagnoses received propensity score matching used control differences groups children current level functioning current characteristics may related diagnosis loss approximately children ever diagnosed autism spectrum disorder estimated lost diagnosis parents believed changed due new information previously diagnosed children less likely parents early concerns verbal skills nonverbal communication learning unusual gestures movements also less likely referred diagnosed specialist previously diagnosed children less likely ever received diagnosis asperger disorder autistic disorder
background aims association health anxiety maladaptive internet use well established finding studies performed examine possible effect abnormal illness behavior aib aib maladaptive manner experiencing evaluating acting response health illness disproportionate evident pathology aim study investigate association aib internet addiction severity sample italian university students possible effect alexithymia anxiety depression also taken account methods participants men women mean age years aib measured via illness behavior questionnaire ibq severity internet addiction test iat results powerful ibq factor predicting severity scores disease conviction irritability emotional ibq factor associated severity nevertheless disease conviction alexithymia remained significant predictors iat scores hierarchical regression analysis executed discussion conclusions results support previous findings showing characterized health anxiety prone excessive maladaptive use internet moreover study showed irritability emotional aspect aib predicting severity finding consistent cognitive model hypochondria states cognitive factors dysfunctional beliefs assumptions play major role explanation psychopathological condition
electric power steering eps spoke type brushless blac motors offer distinct advantages electric motor types terms torque smoothness reliability efficiency paper deals shape optimization spoke type blac motor order minimization cogging torque paper examines step skewing rotor angle optimizing rotor core edge rotor overlap length minimize cogging torque spoke type blac motor methods applied existing machine designs performance calculated using finite element analysis fea prototypes machine designs constructed experimental results obtained shown fea predicted cogging torque nearly reduce using method
coping intelligence defined efficient individual ways managing life stress paper presents new assessment instrument named coping ciq coping intelligence questionnaire measure based multidimensional positive coping model includes three cross cutting parameters characterize coping strategy efficient inefficient emotional cognitive behavioral active passive results factor analysis verified basic two factor structure coping intelligence alternative solutions efficient inefficient coping strategies characterized via three basic modalities validity coping instrument showed internal consistency ranging unified methodology underlies new concept coping intelligence well coping assessment applicable studying clinical general populations ciq parameters might serve useful feedback assessing changes individual coping repertoire ciq measures strategies modified result life experiences educational training based study findings coping intelligence defined broad repertoire life skills required solve successfully everyday stress life adversities order achieve desired goals maintain physical mental social well
introduction cancer term used diseases abnormal cells divide without control able invade tissues gemcitabine new cytotoxic drug limitations use likes suppress activity bone marrow effect blood forming cells lower half life min unable deliver oral route higher dose require malignancies effective various solid tumor like colon lungs breast etc several attempt made enhance efficacy gemcitabine tumor including novel stealth liposomal technology might proves avoids limitation method present investigation focuses enhance encapsulation gemcitabine inside vesicle adopting gradient methods followed solvent evaporation resulting formulation liposomes characterize vesicle size zeta potential zeta sizer along encapsulation efficiency centrifugation optimization formulation carried statistically factorial design optimized formulation subjected vitro antitumor activity cell line study vivo performance using animal model results stealth liposomal formulation comparatively evaluated conventional liposomes pure drug based cell line study proves stealth liposomes effectively retarding tumor cell growth others bio distribution profile stealth liposomes various organs assure prolong circulation half formulation maximum tumor concentration drug even hrs study sign toxicity administration supported data obtained toxicity studies conclusion final outcomes research antitumor activity gemcitabine improved pegylation stealth technology also minimize unwanted toxicities associated gemcitabine via route administration
commentary discuss smartphone apps psychiatry lack resources assist clinicians evaluating utility safety efficacy apps evaluating app requires new considerations beyond employed evaluating medication typical clinical intervention based software engineering informatics clinical knowledge experiences propose evaluation framework aspects spark discussion apps aid clinicians determining whether app actionable secure professional evidence based customizable transparent clinicians use aspects guide informed able make thorough evaluations apps copyright physicians postgraduate press inc
suicide pervasive problem worldwide investigation show individuals perceive suicidality facial appearance accuracy significantly greater chance guessing inferences expected obvious cues depressed person seems lead accurate judgments rather perceptions impulsive individual appears differentiated suicide victims living controls teasing apart various forms impulsivity revealed perceptions impulsive aggression distinct forms impulsive behavior impulsive buying distinguished suicide victims controls finally experienced mental health clinicians perform significantly better laypersons judging suicidality facial appearance may therefore hold cues suicidality expanding known expression perception social cues face providing new insights relationship mental health nonverbal cues
pursue study effective real time feedback technology enhanced learning developed presentation trainer tool designed support practice nonverbal communication skills public speaking tool tracks user voice body analyze performance selects type real time feedback presented paper describes empirical study tested effects presentation trainer feedback learners used tool practicing elevator pitch results study reveal feedback significant effect learners motivation confidence self awareness performance
incontinence common problem among hospitalized patients associated multiple health complications including incontinence associated dermatitis iad hospital acquired pressure ulcers hapus prospective descriptive study conducted acute care neurology units assess prevalence incontinence incidence iad hapus among incontinent patients evaluate effect caregiver education use step cleanser moisturizer barrier product development iad hapus among patients incontinence period month incontinence status admitted patients recorded skin assessed presence absence iad hapus twice per day month data collection clinicians study units completed facility based online education program iad hapus skin care followed implementation step cleanser barrier product skin care patients incontinence data collection procedures remained data collected using paper pencil instrument entered spreadsheet analysis descriptive statistics calculated prevalence incidence rates compared pre intervention post intervention phase using fisher exact analysis first phase study admitted patients incontinent developed iad patients developed hapus admitted average length stay range days intervention phase study patients incontinent none developed iad hapu average length stay range days average braden scale score pre intervention group patients incontinence intervention group prevalence incontinence among patients admitted acute care neurology units rate iad populations high educating clinicians implementing incontinence care procedures step product rate hapus decreased significantly rate iads remained clinicians consider results studies developing incontinence care protocols controlled clinical studies utilizing detailed iad assessments help elucidate observations
secure summation one applicable functions secure multiparty computation mpc group users securely computes summation value private inputs current solutions problem basically adding random number private inputs splitting inputs among users need secure channel among members moreover resistant collusion players impose high communication cost paper propose three cryptography based protocols secure sum need secure channel secure collusion players also communication cost proposed protocols complexity based privacy requirements proposed protocols provide final result privacy well private input privacy
background preceding release american college cardiology acc american heart association aha cholesterol guidelines prescribers aimed specific low density lipoprotein cholesterol ldl goals patients atherosclerotic cardiovascular disease ascvd guidelines changed focus treating patients appropriate statin intensity given ascvd risk examined statin use ldl levels acc aha guidelines patients clinical ascvd defined guidelines methods results conducted retrospective cohort study adult commercial medicare advantage health plan enrollees optum research database patients claim diagnosis clinical ascvd november december continuously enrolled months baseline months follow first ascvd visit patients assigned monthly cohorts based ascvd event month statin use intensity measured baseline first month follow ldl changes assessed using ordinary least squares regression patients mean age years female commercial insurance statin use remained consistent guidelines respectively patients receiving statins high intensity use increased percentage points year guidelines mean ldl levels mmol pre postguidelines conclusions statin use mean monthly ldl guidelines remained largely unchanged statin intensity increased modestly effort may needed increase guideline understanding adherence improve treatment highrisk patients
compelling innovative approach teaching gross anatomy use computer aided holographic models allow clean time saving dissection manipulation structures appreciation anatomical relationships potential elimination need cadavers present study tests hypothesis using holographic models improves mastery anatomical information first year medical students taught gross anatomy using dissection donor cadavers manipulation digitized dimensional holographic renderings examination plastinated specimens effectiveness approaches assessed comparing students performance identification questions cadavers holographic models plastinated specimens students top quintile class performed strongly contrast performance students bottom quintile uneven scored best performance relatively non discriminating students top quintile scored higher biological sciences section medical college admission test mcat students lowest quintile whereas students lowest quintile higher scores verbal section mcats availability different approaches presenting gross anatomy improves success students mastering material particularly students struggling information use holographic models apparently reaches students may challenged learn material using traditional approaches may linked potentially predictive information gleaned performance mcat clin anat wiley periodicals inc
objective three aims report first describe research evidence informed service development rationale new statewide eating disorder service seds people aged years older second examine profile people accessing seds first years operation respect three broad dimensions illness stage illness severity previous history treatment finally examine patient characteristics resulted recommendation ongoing treatment contact seds method year period july july people referred service consented data used research results half referrals related anorexia nervosa remainder split bulimia nervosa specified feeding eating disorders previously received treatment eating disorder initial information service typically provided general practitioner primary care physician compared eating disorder diagnosis people three times likely recommended retain treatment contact seds discussion service development informed research evidence clinical expertise consideration patients characteristics values circumstances allows flexible accountable development strategy
psoriatic arthritis psa chronic condition characterized diverse set symptoms swollen joints nail disease skin disease variety treatment options available including tumor necrosis factor inhibitors tnfis little known treatment persistence patients psa initiate tnfi therapy without prior biologic use study assessed persistence subgroups patients psa identified factors associated persistence retrospective study utilized data corrona registry patients psa without prior biologic experience initiated tnfi therapy october march kaplan meier curves estimated median time nonpersistence discontinuation switch another biologic cox proportional hazards models identified factors associated tnfi nonpersistence total tnfi initiations identified biologic biologic experienced patients years follow biologic biologic experienced patients remained persistent biologic patients greater mean time nonpersistence compared biologic experienced patients months moderate high disease activities based clinical disease activity index disease duration associated persistence biologic biologic experienced patients additionally biologic experienced patients number prior medications skin disease associated persistence majority patients psa study persistent tnfi therapy biologic patients greater persistence compared biologic experienced patients predictors persistence differed slightly biologic biologic experienced patients
sustained controllable release insulin strongly required achieve ideal treatment diabetes previously developed self assembly pegylation retaining activity spra technology via host guest interaction pegylated beta cyclodextrin adamantane appended insulin resulting pegylated insulin termed spra insulin far also demonstrated covalently pegylated insulin forms polypseudorotaxanes pprxs cyclodextrins pprx technology present study designed evaluated combination system spra technology pprx technology achieve sustained controllable release system insulin spra insulin formed pprxs alpha cyclodextrin gamma cyclodextrin addition spra insulin cyclodextrin pprxs provided sustained controllable release insulin beyond single technology vitro vivo results suggest combination system spra technology pprx technology useful design sustained controllable release system insulin elsevier ltd rights reserved
flat enzyme based lactate biofuel cell elbc integrated power management system pms developed potential power supply wearable sensors kinetic models power output chemical reagent concentration lactate oxidase lox lactate developed determine limiting factor elbc performance given lactate concentration human sweat optimum lox amount coated anode ranged based experimental maximum power output elbc pms entity simulation test power discharge recharge frequency calculated self sustained sensing data transmission indicating elbc could support wearable sensors power requirement signal transfer frequency times electrochemical activity lox coated anode validated using cyclic voltammetry coefficient variance regression statistical analysis revealed high stability long lifespan weeks elbc without need lactate refill published elsevier ltd
one dimensional finite element method generally layered smart beams presented paper model implements first order shear deformation beam theory based preliminary analytical condensation electric state mechanical state allows establish effective mechanical beam kinematically equivalent original smart beam including effects electro elastic couplings contributions external electric loads included equivalent stiffness properties equivalent mechanical boundary conditions hermite shape functions depend parameters representative staking sequence equivalent electro elastic stiffness coefficients used formulate finite element method state space representation invoked assembled smart beam finite element model favor implementation block diagram environment multi domain simulation validation results solutions passive active vibrations damping system presented last
use data collected near miss reports added value safety high hazard industries aviation process industry procedure yet taken root construction management practice although management near miss reporting systems collection near miss event reports focus recent research efforts structural analyses reports yet investigated paper reports multi phase research studied near misses related crane work safety risk potential former research stages concentrated collecting near miss well accident stories established structured database tower crane related events reported events classified five homogeneous clusters potential escalating accidents given outcome severity level assessed research stage reported paper builds results previous stage results implements analytic hierarchy process ahp evaluate quantitative outcome severity level values thus computing event total risk potential research outcomes reveal inter relations technical factors human factors tower crane domain application demonstrated using risk potential values construction company safety assessments elsevier ltd rights reserved
purpose article determine usefulness means method applied decompose reduce term document matrix use gpu computations reduction based truncated svd decomposition long term process large matrices computational complexity svd decomposition use means decomposition reduction reduce computational complexity addition use gpu reduce time whole process article comparison times correctness results computing environments associated gpu
reservoir geomechanics play important role hydrocarbon recovery mechanism eor process reservoir geomechanics analysis concerned simultaneous study fluid flow mechanical response reservoir injection accurate prediction geomechanical effects injection assist modeling carbon dioxide recovery process making better design process production equipment paper deals implementation program fortran interface code developed couple conventional reservoir eclipse geomechanical abaqus simulators using partial coupling algorithm geomechanics reservoir partially coupled approach presented allows iteratively take impact geomechanics account fluid flow calculations therefore performs better prediction process proposed approach illustrated realistic field case reservoir geomechanics coupled models show case lower maximum bottom hole injection pressure cumulative oil production scenarios moreover high injection pressures production rates change injection bottom hole pressure variations also fem analysis reservoir showed injection pressure psi plastic strain occurred parts reservoir related stress path show critical behavior
experimental autoimmune encephalomyelitis eae common model multiple sclerosis mainly mediated cells demyelination neurodegeneration central nervous system cns loss receptor might associated pathogenesis eae potential mechanism still clear study severe eae developed knockout mice compared mice knockout increased expression sera proportion cells spleen cns however vitro studies showed influence cell differentiation proliferation cells bone marrow derived dendritic cells bmdcs loss significantly increased production contrast wild type bmdcs facs analysis indicated culture supernatant deficient dcs promoted naive cells differentiate cells finding demonstrated genetic deletion receptor broke balance subtypes affecting cytokine profile bmdcs resulted aggravated eae suggested may potential target treating elsevier inc rights reserved
background tachycardiomyopathy tachycardia induced cardiomyopathy tcm known decades reversible form nonischemic cardiomyopathy however mechanism properties remain poorly understood objectives current study investigated endomyocardial biopsy samples patients tcm compared samples patients dilated cardiomyopathy dcm inflammatory cardiomyopathy icm methods study included patients new onset heart failure severely reduced ejection fraction caused valvular ischemic heart disease nineteen patients retrospectively fulfilled common criteria tcm patients diagnosis dcm diagnosis icm results patients tcm basis clinical criteria stronger myocardial expression major histocompatibility complex class molecule enhanced infiltration macrophages compared patients dcm furthermore compared patients icm presence cells macrophages significantly reduced tcm myocardial fibrosis detected significantly lower degree patients tcm compared patients dcm icm electron microscopic examination revealed severe structural changes patients tcm disturbed distribution pattern mitochondria predominantly present tcm quantitative assessment myocyte morphology revealed significantly enhanced myocyte size compared patients icm ribonucleic acid expression analysis identified changes metabolic pathways among patient groups conclusions tcm characterized changes cardiomyocyte mitochondrial morphology accompanied macrophage dominated cardiac inflammation thus prospective studies warranted characterize patients tcm endomyocardial biopsy clearly american college cardiology foundation
solar pasteurization effective reducing level indicator organisms stored rainwater within drinking water standards however legionella spp detected temperatures exceeding recommended pasteurization temperatures using polymerase chain reaction assays aim current study thus apply ema quantitative polymerase chain reaction ema qpcr determine whether legionella spp detected intact cells therefore possibly viable pasteurization temperatures degrees bactiter glo microbial cell viability assay also used detect presence atp tested samples atp indicates presence metabolically active cells chemical analysis also indicated anions cations within respective drinking water guidelines exception iron mean aluminium mean detected pasteurized tank water samples levels exceeding recommended guidelines bactiter glo microbial cell viability assay indicated presence viable cells pasteurized temperatures tested percentage atp form relative light units decreasing increasing temperature degrees degrees degrees ema qpcr indicated solar pasteurization significantly reduced mean copy numbers detected increase pasteurization temperature genomic copies dna sample obtained degrees intact legionella cells detected pasteurized tank water samples quantitative microbial risk assessment studies need conducted determine potential health risk associated using water domestic purposes elsevier rights reserved
paper develops new framework analyze design iterative optimization algorithms built notion integral quadratic constraints iqcs robust control theory iqcs provide sufficient conditions stability complicated interconnected systems conditions checked semidefinite programming discuss adapt iqc theory study optimization algorithms proving new inequalities convex functions providing version iqc theory adapted use optimization researchers using inequalities derive numerical upper bounds convergence rates gradient method heavy ball method nesterov accelerated method related variants solving small simple semidefinite programming problems also briefly show techniques used search optimization algorithms desired performance characteristics establishing new methodology algorithm design
alterations cerebral cortex connectivity lead intellectual disability syndrome associated deficit cortical neurons arises prenatal development however pathogenic mechanisms cause deficit yet defined show human dyrka kinase chromosome tightly regulates nuclear levels cyclin embryonic cortical stem radial glia cells modest increase dyrka protein transgenic embryos lengthens phase progenitors alterations promote asymmetric proliferative divisions expense neurogenic divisions producing deficit cortical projection neurons persists postnatal stages moreover radial glial progenitors tsdn mouse model syndrome less cyclin dyrka triplicated gene causes early cortical neurogenic defects decreased nuclear cyclin levels model data provide insights mechanisms couple cell cycle regulation neuron production cortical neural stem cells emphasizing deleterious effect dyrka triplication formation cerebral cortex begins onset neurogenesis relevant search early therapeutic interventions syndrome authors published elsevier open access article license http creativecommons org licenses
hiv chronicity resulted increased life expectancy many african american women acquired disease epidemic peak years women live longer age social support needs may increase five focus groups conducted washington hiv positive african american women aged explore women perceptions aging hiv chronicity affects social support needs participants recruited longitudinal women interagency hiv study wihs participant pool constant comparison approach applied data analysis participants reported needing increased social support especially emotional support health care providers family hiv positive peers importance providers hiv positive peers discussed frequently relative meeting needs health care providers particular may need increase provision emotional support devising treatment plans meet social support needs older hiv positive african american women
brief investigates cycle cycle transient behavior residual gas fraction rgf terms systems theory proposes multivalued logic based optimal control strategy attenuation rgf fluctuation first incylinder pressure based method measuring rgf provided stochastic properties rgf examined based statistical data obtained conducting experiments full scale internal combustion engine test bench based observation experiment stochastic logical transient model proposed represent cycle cycle transient behavior rgf optimal feedback control law targets rejection rgf fluctuation derived using policy iteration algorithm finally experimental result demonstrated show effectiveness proposed optimal control law
contraceptive counselling begin early females heart disease preferably directly start menstruation coming decision method contraception following issues considered risk pregnancy mother consequences unplanned pregnancy risks contraceptive method iii failure rates non contraceptive benefits availability individual preferences vii protection infection viii costs women heart disease issues may complex require input cardiologist obstetrician feto maternal expert identify optimal approach studies performed women heart disease investigate relative risks benefits different contraceptive methods
background purpose cerebral venous thrombosis cvt affects venous hemodynamics provoke severe stroke chronic intracranial hypertension sought comprehensively analyze dimensional blood flow hemodynamic alterations acute cvt including collateral recruitment follow methods twenty two consecutive patients acute cvt prospectively included underwent routine brain magnetic resonance imaging mri dimensional flow mri vivo assessment cerebral blood flow neurological mri follow months performed patients results three dimensional blood flow visualization quantification large dural venous sinuses deep cerebral veins successfully performed patients acute cvt observed abnormal flow patterns including stagnant flow flow acceleration stenoses change flow directions patients complete recanalization flow trajectories resembled known previously published dimensional flow mri data healthy adults trend toward relationship occluded segments cerebral lesions significant furthermore patients versus without cerebral lesions showed increased mean versus peak velocities versus within partially thrombosed left right transverse sinuses baseline conclusions four dimensional flow mri successfully applied dimensional visualization quantification venous hemodynamics patients cvt provided new dynamic information regarding vessel recanalization technique seems promising investigate contribution hemodynamic parameters collaterals larger cohort identify risk stroke
background despite overall success total hip replacement thr patients symptomatic osteoarthritis one quarter patients report suboptimal recovery aim study determine whether social support general self efficacy predict variability short term recovery norwegian cohort methods performed secondary analysis prospective multicenter study patients underwent thr total score western ontario mcmaster universities osteoarthritis index womac months surgery used recovery variable measured self efficacy using general self efficacy scale gses social support social provisions scale sps preoperative postoperative scores compared using wilcoxon tests mann whitney test compared scores groups differed gender age spearman rho correlation coefficients used evaluate associations selected predictor variables recovery variable performed univariate multiple linear regression analyses identify independent variables ability predict short term recovery thr results median preoperative womac score surgery mean absolute change standard deviation mean relative change older age female gender higher educational level number comorbidities baseline womac score self efficacy three six individual provisions correlated significantly short term recovery thr predicted variability recovery univariate regression model multiple regression models baseline womac consistent predictor short term recovery higher preoperative womac score predicted worse short term recovery beta higher self efficacy predicted better recovery beta reliable alliance significant predictor improved recovery beta conclusions patients general self efficacy expectation others tangible assistance predict recovery thr researchers clinicians target psychosocial factors together patients families improve quality care surgical outcomes
early childhood experience social determinant children health well well young children founded relationships interactions parents family members home caregivers teachers early education friends families greater community unfortunately early language experience infants toddlers low income families typically vastly different children middle higher income families hart risley meaningful differences everyday experience young american children brookes baltimore described million word gap experienced age four children poor families compared economically advantaged families measured number words delivered adults home children discrepancy groups associated deficit vocabulary growth time hart risley meaningful differences everyday experience young american children brookes baltimore social world children learning talk brookes baltimore educ spring readiness enter preschool kindergarten compared advantaged classmates purpose paper conceptualize population level public health prevention approach research addressing harmful impacts word gap approach includes use evidence based practices improve children language environments foster early language literacy learning early childhood brief review word gap discuss four aspects conceptual framework community leadership team driver local intervention evidence based language interventions reducing gap promoting child language measurements needed implications discussed
oral immunotherapy may offer alternative elimination diets peanut allergy children treatment proposed following oral challenge test tpo agreed entered personalised oral immunotherapy study treatment failures patients underwent second oral challenge treatment tpo cumulative reactogenic dose clinical severity score compared skin tests assay ige specific peanut allergy first performed prior tpo follow mean age patients years median time two challenge tests years mean cumulative reactogenic dose tpo peanut tpo peanut increased significantly conversely clinical severity score significantly reduced two challenge tests serious adverse effects reported immunotherapy treatment paediatric population administered patients homes confirms efficacy therapy well acceptable benefit risk ratio consistent data oral immunotherapy peanut allergy part personalised therapeutic approach children food allergies elsevier masson sas rights reserved
main objective paper analyze effect mhd heat generation radiation nanoparticle volume concentration unsteady natural convective flow nanofluid past impulsively started infinite vertical plate nanofluids involving nanoparticles silver aluminum oxide copper titanium oxide nanoparticle volume concentration range smaller equal taken numerical solutions governing boundary value problems obtained help laplace transform algorithm symbolic computation software maple effects mhd heat generation radiation nanoparticle volume concentration velocity temperature profiles depicted graphically skin friction coefficient nusselt number also investigated
job shop scheduling problem jsp widespread real world production system one general important problems various scheduling problems nowadays effective method jsp hot topic research area manufacturing system jsp typical hard combinatorial optimization problem broad engineering application background due large complicated solution space process constraints jsp difficult find optimal solution within reasonable time even small instances paper hybrid particle swarm optimization algorithm pso based variable neighborhood search vns proposed solve problem order overcome blind selection neighborhood structures hybrid algorithm design new neighborhood structure evaluation method based logistic model developed guide neighborhood structures selection method utilized evaluate performance different neighborhood structures neighborhood structures good performance selected main neighborhood structures vns finally set benchmark instances conducted evaluate performance proposed hybrid algorithm comparisons among state art reported algorithms also presented experimental results show proposed hybrid algorithm achieved good improvement optimization jsp also verifies effectiveness efficiency proposed neighborhood structure evaluation method elsevier ltd rights reserved
researchers proposed leader support helps employees behave proactively work leader support facilitate opportunities employees bring change well motivation nevertheless empirical studies shown mixed effects leader support employees proactive behavior study reconcile inconsistent findings impact leader support employees proactive behavior authors consider content mediating mechanisms boundary conditions leader support shaping employees proactive behavior basis attachment theory authors propose secure base support leaders support form leader availability encouragement noninterference positively predicts employees proactive work behavior increasing role breadth self efficacy autonomous motivation hypotheses supported online survey sample participants sample large gas oil company china authors propose beneficial effects secure base support leaders prominent individuals lower attachment security hypothesis also supported individuals high attachment anxiety especially benefited leader secure base support terms effect role breadth self efficacy whereas high attachment avoidance especially benefited leader secure base support terms effect autonomous motivation study helps explain leaders support motivates employees proactive behavior particularly individuals lower attachment security
background aims functional bowel disorders fbds impair quality life patients end stage renal disease esrd aim study determine prevalence distribution subtypes fbds hemodialysis patients materials methods prospective cross sectional study included patients received months patient group healthy controls control group fbds diagnosed according rome diagnostic criteria excluding organic pathologies results forty six patients males average age years mean duration dialysis months mean dialyzer clearance urea dialysis time volume distrubition urea value rate fbds significantly higher patient group control group total patients irritable bowel syndrome functional bloating functional constipation fbds significantly higher women statistically significant difference patients without fbds terms presence additional diseases smoking alcohol use educational level marital status residential areas serum phosphorus levels significantly higher patients fbds conclusion fbds functional constipation subtype common patients healthy population turkey fbds frequently observed females housewives high serum levels
background chondrosarcomas rare malignant slow growing tumors develop near petroclival region brain report rare case tumor originated left petrous bone induced intraventricular hemorrhage leading acute comatose presentation case description year old man initially presented outpatient department month history headache vomiting vertigo left facial numbness lesion cerebellopontine angle extension middle cranial fossa demonstrated computed tomography magnetic resonance imaging following night condition worsened presented emergency department intraventricular hemorrhage hydrocephalus external ventricular drain placed emergency department relieve hydrocephalus definitive surgical resection tumor subsequently postoperatively glasgow coma scale score improved transferred surgical intensive care unit remained days subsequently stepped special care unit ward room patient currently awake grade facial palsy house brackmann demonstrates spontaneous purposeful eye opening inconsistently obeys single step orders demonstrates meaningful phonation vocalization least grade power extremities currently fed nasogastric tube rehabilitation conclusions experience petroclival junction chondrosarcoma causing intraventricular hemorrhage may first documented preferred treatment highly malignant lesion radical removal postoperative radiotherapy
objective structural functional brain alterations major depression disorder mdd well studied cross sectional designs little known causality onset course depression one hand neurobiological changes time explore direction causality longitudinal studies long time window preferably years needed undertaken far article reviews prospective neuroimaging studies mdd patients currently available provides critical discussion methodological challenges involved investigation causal relationship brain alterations course mdd method conducted systematic review studies published september identify structural magnetic resonance imaging mri studies assess relation neuronal alterations mdd longitudinal year designs results studies meeting minimal standards identified analysis longitudinal data showed large heterogeneity studies regarding design samples imaging methods spatial restrictions consequently results strong relationship brain volume outcomes current mood state whereas longitudinal studies failed clarify influence pre existing brain changes depressive outcome conclusion far available longitudinal studies resolve causality course depression neurobiological changes time future studies combine high methodological standards large sample sizes cooperation multi center studies indispensable attain sufficient sample sizes allow careful assessment possible confounders
digitally controlled sonar power amplifier underwater transmitter explained paper proposes method generating unipolar sine pulse width modulation spwm signals echo ranging sonar method effectively used kinds inverters including high frequency inverters low cost digital signal controller used generate spwm signals used gating pulses controlled full bridge circuit cfbc power required frequency pulse width pulse repetition interval given inputs digital controller gating pulses cfbc generated output controller power transformer connected across cfbc boosts output voltage followed power filter removes unwanted harmonics present output output power filter used excite electro acoustic transducer elements underwater voltage current load given feedback controller voltage mode control loop implementation system prototype switch mode power amplifier smpa echo ranging sonar designed digital control implemented salient results presented
three studies examined role need affect nfa need cognition nfc intergroup perception hypothesized nfa predicts preference stereotypically warm groups stereotypically cold groups whereas nfc predicts preference stereotypically competent groups stereotypically incompetent groups study supported hypotheses attitudes toward stereotypically ambivalent groups stereotyped high one trait dimensions high warmth low low competence stereotypically univalent groups seen high low dimensions studies replicated pattern stereotypically ambivalent groups yielded provocative evidence regarding several putative mechanisms underlying associations together findings help integrate extend past evidence attitude relevant individual differences research intergroup perception
triaxial force sensitive microrobot developed dynamically perturb skin multiple deformation modes vivo wiener static nonlinear identification used extract linear dynamics static nonlinearity force displacement behavior skin stochastic input forces applied volar forearm thenar eminence hand producing probe tip perturbations indentation tangential extension wiener static nonlinear approaches reproduced resulting displacements variances accounted vaf ranging indicating good fit data approaches provided vaf improvements linear models thenar eminence stiffness measures approximately twice measured forearm damping shown significantly higher palm whereas perturbed mass typically lower coefficients variation cvs nonlinear parameters assessed within across individuals individual cvs ranged indentation extension stochastic perturbations incrementally increasing mean amplitudes applied test areas differences full scale incremental reduced scale perturbations investigated different incremental preloading schemes investigated however significant difference parameters found different incremental preloading schemes incremental schemes provided depth dependent estimates stiffness damping ranging respectively surface greater depths device techniques used research potential applications areas evaluating skincare products assessing skin hydration analyzing wound healing
objective need address cultural beliefs parenting practices regarding childhood obesity design effective weight control programmes overweight obese latino children purpose current study explore cultural beliefs children weight understand parent perceptions feeding children explore barriers interfere healthy lifestyle design four focus groups conducted spanish forty one latino mothers elementary school age children san diego county california april may cultural viewpoints overweight status among children barriers leading healthy lifestyle explored focus group discussions analysed based priori emergent themes results three themes identified mothers cultural beliefs health barriers family health mothers primary caretakers family health iii attitudes targeting children weight mothers acknowledged idea chubby better misperception yet chubby child preferred even accepted mothers described fatalistic beliefs contradicted existing knowledge chronic disease daily demands western culture barriers practising healthy behaviours home family caretaker conclusions findings may used inform culturally appropriate research address latino health increasing awareness cultural beliefs daily circumstance could help address obesity directly thereby overcome potential underlying barriers might exist involving latino immigrant families obesity treatment prevention
present study investigated predictive utility self reported domestic violence perpetrators exposure violence family origin patterns related exposure use longitudinal analyses sample men probation lake county illinois differences typology recidivism recidivism frequency violent behavior survival patterns men history domestic violence perpetration varying levels family origin violence exposure examined findings suggest witnessed interparental violence either alone combination experiencing violence likely classified generally violent offenders perpetrators direct violence toward family others compared report experiencing witnessing violence addition results also indicate men experienced witnessing interparental violence receiving physical abuse childhood likely recidivate frequently compared report experiencing witnessing violence significant findings typology recidivism noted clinical policy practice implications discussed elsevier ltd rights reserved
objectiveto determine whether staff responses abuse disclosures improved since introduction trauma policy training programme methodthe files clients attending four new zealand mental health centres audited resultsthere significant improvement compared audit prior introduction policy training proportion abuse cases included formulations lesser extent treatment plans significant improvement proportion referred relevant treatment remained less across abuse categories proportion neglect disclosures responded significantly lower abuse cases fifty percent files abuse neglect recorded noted whether client asked previous disclosure noted whether client thought connection abuse neglect current problems less cases reported legal authorities people diagnosed psychotic disorder significantly less likely responded appropriately conclusionfuture training may need focus responding well neglect people diagnosed psychosis making treatment referrals initiating discussions reporting authorities
humans closest extant relatives anthropoids notable reduced snout striking reduction facial projection superficial similarity anthropoids including long faces baboons lost numerous internal projections turbinals spaces recesses sum equates loss certain regions olfactory mucosa anthropoids addition accessory olfactory organ vomeronasal organ non functional even absent catarrhine primates humans apes monkeys commentary revisit concept anatomical reductions pertains anthropoid nasal region certain nasal structures spaces anthropoids exhibit well known attributes known vestiges variability form number cupular recess vestige olfactory recess rudimentary ethmoturbinals constitute reduced structures presumably fully functional ancestors humans least apes retain vestige bereft chemosensory function catarrhine monkeys completely absent however function vomeronasal system also includes prenatal roles may common mammals notably neurons migrate brain along vomeronasal terminal nerve axons embryogenesis time specific role vno raises possibility concept functional reduction static vomeronasal system humans catarrhine primates appears qualify chronological vestige one fulfills part function ontogeny becomes lost vestigial anat rec wiley periodicals inc
pipeline transportation industry expanded significantly convenience speed faces problems research study failure piping caused water hammer behavior check valve pump stops working causes loud noise pipe deformed due vibration therefore research analyzes deformation pipeline due pressure surge measures vibration piping system check valve works resulting analysis used predict phenomenon cause deformation pipeline principles fluid structure interactions using theory fluid theoretical mechanics materials engineering used solve problems occur khon kaen beer thailand research modeling analysis piping systems uses ansys program results show predicted failures match actual pipelines
purpose study designed contribute existing research coping behaviors social support mental health outcomes parents children epilepsy united states methods participants included predominantly caucasian married women via web based interface mothers completed questionnaires assessing impact child disability family severity child disability family burden personal stress social resources perceived social support coping emotion focused social support seeking adjustment depression anxiety results controlling demographic variables mediational analysis revealed mothers perceptions severity child disability associated decreased perceived social support related higher reported levels depression anxiety similarly low levels perceived social support partially mediated relation family burden depression anxiety stress finally mothers perceptions severity children disability family burden unrelated reports emotion focused social support seeking coping however use emotion focused social support seeking behaviors related lower levels depression conclusion low levels perceived social support may help explain mechanisms underlying relation mothers perceptions severity child disability family burden mental health adjustment depression anxiety elsevier inc rights reserved
students studied native language face difficulty acquiring programming skills english medium instruction one solution create screencasts live coding along instructor explanations native language paper examine impact screencast based self paced learning hindi medium native language students study three groups one group hindi medium prior instruction learned programming screencasts hindi another group also hindi medium prior instruction learned screencasts english third group english medium prior instruction learned screencasts english compared performance three groups using post test items fact concept process content types found hindi medium students studied hindi screencasts performed well english medium students studied english screencasts groups performed better hindi medium students studied english screencasts effect medium instruction significant content types fact process concept
traditional rdbms consistent normalized data structures rdbms served well decades technology optimal data processing analysis data intensive fields like social networks oil gas industry experiments large hadron collider etc several challenges raised recently scalability data warehouse like workload transactional schema particular analysis archived data aggregation data summary accounting purposes paper evaluates new database technologies like hbase cassandra mongodb commonly referred nosql databases handling messy varied large amount data evaluation depends upon performance throughput scalability technologies several scientific industrial use cases paper outlines technologies architectures needed processing big data well description back end application implements data migration rdbms nosql data warehouse nosql database organization could useful data analytics
patients atrial fibrillation closure left atrial appendage laa recommended prevent thromboembolic events however conventional exclusion excision techniques potential drawbacks persistent blood flow appendage residual stump propose simple easy technique laa closure consisting intra atrial excision laa invaginated left atrium direct suture closure orifice inside technique complete elimination laa achieved without leaving residual stump laa excised orifice closed base laa
ensure bridge safety functionality service conditions detecting local abnormalities long span bridge early stage always desirable challenging task stress influence lines sil derivatives recognized promising indices damage detection compared bridge global responses displacement acceleration stress strain conveniently measured often sensitive local damages paper explores novel damage localization approach synthesizing sil measurements multiple locations dempster shafer data fusion technique utilized compared measurement single sensor reliable damage related information improved sensitivity capability damage localization obtained synthesizing measured sils number sensors effectiveness proposed method validated numerical case study tsing suspension bridge different hypothetical scenarios including single damage case double damage damage cases considered validation comparison damage detection results using single sensor data clearly indicates data fusion technique effectively enhance consistency information damage induced structural change minimize non consistent information noise effect multiple sensors installed close damage increasing number sensors benefits damage detection results excellent damage detection accuracy achieved different types bridge components properly selected monitoring therefore promising use proposed approach study damage localization real world long span bridges parametric studies conducted examine effects parameter selections noise levels approach
present hills high level language system specification graphical formalism allows specify discrete event system des models analysis using methodologies like simulation formal methods enactment hills syntax built integration concepts system theory software engineering aided simple concrete notations describe structural behavioral aspects dess paper provides syntax hills simulation semantics based discrete event system specification devs formalism devs based modeling simulation perspective hills platform independent visual language generic expressions serve front end existing devs based simulation environments aid model driven engineering mde techniques also suggests ways fill gaps existing devs based visual formalisms inhibit complete specification behavior complex dess provide case study illustrate core features language
objectives incidence prevalence data obtained injury surveillance studies could biased response rate well completeness quality reports therefore appears crucial analyse quality injury surveillance system thereby validate quality data study aimed analyse quality compliance injury surveillance system implemented international athletics championships design prospective epidemiological study methods national medical teams local organising committee physicians daily reported injuries standardised injury report form international athletics championships quality injury surveillance system analysed following guidelines laid centre disease control prevention results average mean standard deviation registered countries participated injury surveillance project accounting coverage athletes registered athletes medical staff returned expected injury report forms information missing one championship completeness injury data provided medical teams local organising committee physicians averaged national medical teams reported injuries local organising committee physicians whereas injuries reported conclusions injury surveillance system used international athletics championships provided good national medical team participation coverage athletes response rate completeness reports parameters systematically reported injury surveillance studies show quality study sports medicine australia published elsevier ltd rights reserved
research shown mimicking someone way solicitors perceived positively increase compliance helping request effect mimicking children compliance request change food consumption however never examined nine year old children either mimicked instructor beginning interaction children asked eat piece fruit afternoon snack least week try eat candy drink soda least week results show children mimicked instructor consumed fruit afternoon snack longer period time children mimicked also asked parents buy fruit wanted continue eating fruit afternoon snack changes fruit consumption confirmed mother results suggest mimicry influence child behavior could used promote changes eating behavior elsevier ltd rights reserved
transition metal oxide thin films prepared thermal evaporation low deposition rate material characterization shows thin films stoichiometric composition tungsten ions fully oxidised surface thin films became smoother thickness increased results show deposition thin film follows island growth flatband voltage extracted values respectively also found large amounts negative charges accumulated interface electron transfer elsevier rights reserved
appreciative joy sympathetic joy refers feeling happiness others one four prosocial attitudes four immeasurables cultivated loving kindness meditation buddhism current study included participants developed scale measure appreciative joy friends daily life exploratory factor analysis confirmatory factor analysis resulted appreciative joy scale consisting three components sense joy positive interpersonal bias self transcendence study appreciative joy scale exhibited high correlations measurements interpersonal relationships four immeasurables scale also shows incremental contributions positive emotions satisfaction life trait happiness peace mind controlling interpersonal relationships four immeasurables studies scale exhibited higher scores among buddhists among individuals religious belief structure maintained across english chinese samples study addition demonstrated good test retest reliability study overall current study validated scale useful tool measuring appreciative joy certain findings also highlighted directions future research appreciative joy including causal relationships positive emotions comparisons compassion effects envy
mushrooms well known immunomodulating capacities however little known mushroom stimulated dendritic cells dcs affect cells therefore investigated effect mushroom compounds derived seven edible mushroom species dcs fate dcs effect mushroom stimulated dcs cells mushroom species stimulated dcs different manner revealed cytokine response assessing maturation revealed one mushroom species agaricus subrufescens induced complete maturation six mushroom species upregulated mhc expression significantly affect expression cdc nevertheless mushroom compounds investigated mushroom species endocytosed dcs endocytosis likely mediated type lectin receptors clrs clr binding dependent egta reduces tnf alpha secretion laminarin partly inhibited tnf alpha secretion indicating clr dectin among clrs involved binding mushroom compounds stimulated dcs shown stimulate cells however physical contact dcs cells required clrs seem play prominent role stimulation mushrooms may function carbohydrate containing adjuvant used conjunction anti fungal vaccines
uncertainty quantification refers quantitative characterization reduction uncertainties present computer model simulations widely used engineering geophysics fields assess predict likelihood various outcomes paper describes platform called pyl uncertainty quantification python laboratory flexible software platform designed quantify uncertainty complex dynamical models pyl integrates different kinds methods including experimental design statistical analysis sensitivity analysis surrogate modeling parameter optimization written python language runs common operating systems pyl graphical user interface allows users enter commands via pull menus equipped model driver generator allows computer model linked software illustrate different functions pyl applying uncertainty analysis sacramento soil moisture accounting model also demonstrate pyl applied wide range applications authors published elsevier ltd
big end bearing knock faults engines considered real industrial case slider crank mechanism including joint clearance lubrication paper artificial neural network ann based system used solve problem intelligent big end bearing knock fault diagnosis internal combustion engine ann used machine condition monitoring either unlikely uneconomical experience different real faults generate sufficient training data therefore model based method viable way generate adequate data train networks intelligent big end bearing fault diagnosis engines order evaluate update simulation model experiments normal bearing clearance different oversize bearing clearances first carried engine test rig found relevant diagnostic information lies squared envelope vibration signals therefore need build proper simulation model simulate correct envelope signals rather raw vibration signals important inputs simulation model inertia properties simulated engine components also measured studied next built ann based bearing knock diagnosis system consists three phases fault detection phase fault localization phase fault severity identification phase particularly saturating linear function selected transfer function fault severity identification stage networks linearly classify fault levels output agreement reality industry following feature extraction selection processed squared envelope signals networks purely trained simulated data normal bearing clearance different oversize bearing clearances finally networks tested real experimental data demonstrated networks successfully detect different bearing knock faults real tests also classify faults location severity levels elsevier ltd rights reserved
provide cost effective high performance image patch query image patch analysis implementation one important issue internet image server design paper present one novel approach internet image server design implementation like modern internet image server implementation system stores pre rendered image tiles different scales web server laced together client browser key issues solutions image patch query image patch predicate image patch analysis proposed illustrated paper furthermore key details algorithm design presented paper prototype adopting methods presented related benchmark result details reveal effectiveness efficiency proposal
recent years pso algorithm one popular soft computing technique increasingly used optimizing parameters pid controller however pso optimization algorithm general successfully used solve optimization problems validation functionality must done earlier paper proposed functionality validation pso algorithm focusing fitness functions convergence particles due existence dimensional dimensional pid dimensional controllers functionality validation done dimensional problems test functions used rastrigin rosenbrock experimental results shows proposed pso algorithm coded mat lab successfully proven fit employed optimizing dimensional problems later used optimize pid controllers variants dimensions problems
data collected year olds surveyed nationally three wave longitudinal survey population average generalized estimating equation gee odds carrying weapon school last month estimated function past year exposure violent content video computer internet games well peer aggression biological sex sample included youth risk exposure game play outcome attended public private school observations youth included analyses youth reported carrying weapon school last month reported least games played depicted violence adjusting potentially influential characteristics aggressive behavior playing least violent games past year associated fourfold increase odds also reporting carrying weapon school last month although youth reported frequent intense peer victimization past year likely report carrying weapon school last month relation explained influential characteristics consistent predictions social cognitive observational learning theory study supports hypothesis carrying weapons school associated violent game play one first studies kind findings interpreted cautiously need replicated aggr behav wiley periodicals inc
paper devoted innovative device consisting frees winging piston internal external combustion engine oscillating rotary electrical generator advantages possibilities unit presented compare shortcomings conventional units well units linear free piston internal combustion engine oscillating linear generator principles modelling simulation considered device presented usage proposed unit source energy hybrid electric vehicles enables create competitive hybrid vehicle
background invasive fungal infection ifis major infectious complication immunocompromised patients early diagnosis initiation antifungal therapy important achieve best outcome objectives current study aimed investigate incidence ifis evaluate diagnostic performance non invasive laboratory tests serologic beta glucan galactomannan molecular nested polymerase chain reaction tests diagnose fungal infections hematologic pediatric patients patients methods cross sectional study october january blood samples pediatric patients hematologic disorders high risk fungal infections analyzed non invasive tests including platelia aspergillus enzyme immunoassay eia detect galactomannan antigen glucatell beta glucan nested pcr detect candida aspergillus species specific dna used weekly screening strategy results twenty six patients considered proven probable ifis including proven probable cases eighteen patients considered possible cases sensitivity specificity positive negative predictive values galactomannan test patients proven probable fungal infections beta glucan test nested pcr respectively conclusions rate ifis pediatric patients hematologic disorders high sample collection sterile sites performed immunocompromised patients detection circulating fungal cell wall components dna blood using non invasive methods offer diagnostic help patients suspected ifis results interpreted combination clinical radiological microbiological findings
femoro acetabular impingement fai associated significant acetabular cartilage damage degenerative arthritis understand contact stress thus biomechanical mechanisms may contribute degeneration material behaviour cartilage layer required objective study determine fibril reinforced poroelastic properties composition cartilage cam deformities compare normal cartilage patients undergoing surgical treatment symptomatic cam fai deformity recruited clinical practice one authors osteochondral specimens retrieved deformity surgery using trephine control specimens retrieved anterior femoral head bearing surface autopsy procedures indentation stress relaxation tests performed determine modulus poisson ratio permeability poroelastic component strain independent dependent epsilon moduli fibril reinforcement using finite element analysis optimization safranin staining used quantify proteoglycan content lower respectively cam specimens compared controls approximately triple control specimens significant differences seen fibrillar components epsilon proteoglycan content substantially depleted cam specimens correlated study showed cartilage cam deformity exhibits severe degeneration terms mechanical behaviour composition changes consistent osteoarthritis supports hypothesis fai cause hip osteoarthritis elsevier ltd rights reserved
previous studies linking parent adhd symptoms parenting typically focused parent individually provide broader understanding family context study levels inattention hyperactivity impulsivity mothers fathers examined individually combination relation negative parenting child rearing disagreements two parent families year old boys adhd typically developing participated parents reported adhd symptoms perceptions child rearing disagreements parenting measured using self partner child reports well observations controlling child adhd symptoms inattention symptoms fathers predicted parenting difficulties mothers inattention symptoms linked parenting problems fathers also high levels inattention contrast parenting problematic mothers fathers families fathers higher mothers lower levels hyperactivity impulsivity symptoms results remained essentially unchanged child externalizing behavior mother depression hostility controlled father depression reduced significance interactions results highlight importance match father mother levels symptoms point differential relations parenting inattention hyperactivity impulsivity symptoms parents
turn century novel food processing techniques become commercially important profound advantages traditional methods novel processing methods tend preserve characteristic properties food including organoleptic nutritional qualities better compared conventional food processing methods period time clear rise populations suffering food allergies especially infants children though fact widely attributed changing livelihood population developed developing nations introduction new food habits advent novel foods new processing techniques complete role still uncertain circumstance important understand structural changes protein food processed comprehend whether specific processing technique conventional novel increasing mitigating allergenicity various modern means employed understand conformational changes protein affect allergenicity review processing effects protein structure allergenicity discussed along insinuations recent studies techniques establishing platform investigate future pathway reduce eliminate allergenicity population
effectively addressing low value care calls engaging public including one third americans currently envision benefits avoiding low value care public awareness response low value care enhanced revised media messaging efforts effective emphasize health risks rather financial costs associated unnecessary tests treatments long term robust public support addressing low value care may require shifting focus particular tests treatments emphasize instead potential better communication personalized attention clinicians spend time talking less time testing contextas much health care spending may unnecessary choosing wisely campaign active dozen countries addresses problem part public education campaigns article explores americans understanding low value care assesses impact media messaging tests alternative message framing methodswe use mixed methods design incorporating focus groups exploring americans understanding language low value care intensive interviews patients interactions physicians regarding questions cost value national survey respondents examining awareness low value care survey experiment participants testing impact media messages attitudes low value care treatment choices selection primary care clinician findingsone third americans difficulty envisioning benefits avoiding low value care figure increases half less educated minority respondents americans anticipate benefits hope less testing treatment replaced interactive personalized care even without media priming many americans would avoid common forms low value care like unnecessary antibiotics excess imaging lower back pain favor clinicians avoid practices although public awareness actions increased disparities reduced media messaging conventional messages also exacerbate blame placed providers avoiding low value care enhanced blaming providers reduced disparities diminished messages put emphasis health risks tests treatments conclusionsthe public awareness low value care incomplete substantial disparities related race ethnicity socioeconomic status media messaging help fill gaps short run would enhanced fine tuning low value care characterized longer run building robust public support reducing low value care may require refocusing attention away specific tests treatments toward relational benefits patients clinicians spent less time testing time personalized care
lead exposure pregnancy remains public health problem potential lifelong impacts children growth development mexico unique stunting obesity major public health concerns children situation might exacerbated lead exposure remains common mexico united states due part use lead glazed pottery food preparation storage objective determine lead exposure pregnancy associated children growth parameters including height weight body mass index percentage body fat measured ages years old mexico city pregnancy cohort blood lead collected trimester pregnancy well delivery bone lead assessed mothers long term exposure biomarker performed multivariable linear regression analyses assess association lead exposure biomarkers child anthropometry found significant negative association maternal trimester blood lead concentration offspring height age beta negative association maternal trimester blood lead concentration weight age beta results mexican population add previous findings association lead decreased stature weight early childhood ongoing follow longitudinal analyses may help elucidate impacts growth trajectory children health outcomes
russian roulette splitting considered fundamental importance sampling techniques neutron transport simulations far received relatively little attention light transport computer graphics splitting often based solely local reflectance properties however strategy far optimal common scenes non uniform light distribution accurately predict actual path contribution approach like neutron transport estimate expected contribution path product path weight pre computed estimate adjoint transport solution use estimate generate called weight window keeps path contribution roughly constant splitting result paths unimportant regions tend terminated early important regions spawned splitting results substantial variance reduction path tracing photon tracing based simulations furthermore unlike standard computer graphics approach interfere importance driven sampling scattering directions results superior convergence technique combined approach provide justification behavior relating approach zero variance random walk theory
purpose large numbers older workers remaining global workforce raising questions concerning age related differences perception behavior purpose paper examine interplay employee age gender ethnicity benevolence perceptions new workers design methodology approach data obtained scenario methods sample full time team based employees across nine north american business organizations participants evaluated three provocative scenarios depicting initial meetings new colleagues findings workers greater age perceived significantly less benevolence three scenarios evaluating new boss women perceived lower benevolence men gender moderated relationship age perceived benevolence aging associated significantly lower levels perceived benevolence among men research limitations implications deeper understandings needed concerning behavioral cognitive mechanisms related age workplace perceptions practical implications older employees guided experience skeptical intentions wide variety newly acquainted colleagues signaling organizational leaders customize behaviors develop programs encourage awareness positive relationships across age gender diverse employee groups originality value research uniquely explores age influences interactions gender ethnicity benevolence perceptions diverse new coworkers results robust considering age related lower benevolence perception across three disparate scenario interpretations
introduction considerable amount controversy long term effects multiparity duration breast feeding maternal bone mineral density menopause study conducted determine whether multiple pregnancy prolonged duration breast feeding independent predictors low bone mass post menopausal kurdish women methods retrospective study evaluated post menopausal women mean age years screened osteoporosis dual energy ray absorptiometry dxa according parity children total duration breast feeding months classified bone mineral density bmd results femoral neck lumbar spine classified three groups normal osteopenia osteoporosis according criteria binary logistic regression used assess independent associations low femur spine bmd parity total duration breast feeding results found women children months history total breast feeding older higher prevalence osteoporosis however adjusting age parity independent predictor osteopenia total duration breast feeding independent predictor low bone mass conclusion multiparity detrimental effect maternal bmd history multiple pregnancy risk factor low bone mass post menopausal women however prolonged duration breast feeding long term adverse effect maternal bmd post menopausal age
glucose stimulated insulin secretion gsis islet cell involves well orchestrated interplay metabolic cationic events well established intracellular generation adenine guanine nucleotide triphosphates atp gtp represents one requisite signaling steps gsis small molecular mass gtp binding proteins proteins racl cdc shown regulate islet cell function including actin cytoskeletal remodeling fusion insulin granules plasma membrane gsis occur context several regulatory factors proteins identified pancreatic cell include guanine nucleotide exchange factors gefs guanine nucleotide dissociation inhibitors gdi recent pharmacological molecular biological evidence identified tiam vav gefs racl promoting physiological insulin secretion paradoxically emerging evidence multiple cell types including islet cell suggests key roles racl onset cellular dysfunction conditions metabolic stress diabetes furthermore functional inactivation either tiam vav appears attenuate sustained activation rac downstream signaling events activation stress kinases conditions metabolic stress together findings suggest friendly non friendly roles tiaml vav racl signaling axis islet cell health diabetes current understanding field knowledge gaps exist area islet biology heighted herein furthermore potential caveats specificity selectivity pharmacological inhibitors available currently discussed commentary published elsevier inc
paper describes variable output voltage multi phase switched capacitor step converter digital voltage regulation scheme implemented cmos vlsi technology number conversion ratios generated using flying capacitors order scheme selection switch presented expressions equivalent series resistance req conduction switching power loss efficiency obtained compared cadence spectre simulation results step open loop converter circuit one gain described analysed varying switching frequency open loop converter efficiency achieved bottom plate parasitic capacitance load current input voltage mhz switching frequency gain voltage regulation scheme desired output voltage designed digital control circuit using inherent capacitive dac interpolate various gain configuration flying capacitor simulated cadence analog mixed signal flow using cmos technology layout design using mim cap done back annotation results presented
information motivation behavioral skills imb model useful understanding sexual risk behavior tested hazardously drinking sexually transmitted infection sti clinic patients subpopulation greater hiv risk network perspective sexual risk behavior outcome participants sti clinic patients screened positive hazardous drinking risky sexual behavior sexual risk behavior srb operationalized latent variable three indicators number sexual partners number unprotected sex occasions primary partner number unprotected sex occasions non primary partner preliminary analyses suggested srb best operationalized latent variable two indicators unprotected sex primary partners considered separately structural models good fit imb model generally supported imb model functioned differently non primary multiple partners compared primary partners sti clinic patients hazardous alcohol use
last years cheerleading increased dramatically popularity evolved leading crowd cheers sporting events competitive year round sport involving complex acrobatic stunts tumbling consequently cheerleading injuries steadily increased years number severity sprains strains lower extremities common injuries although overall injury rate remains relatively low cheerleading accounted approximately catastrophic injuries high school girl athletes past years risk factors injuries cheerleading include higher bmi previous injury cheering harder surfaces performing stunts supervision coach low level training experience policy statement describes epidemiology cheerleading injuries provides recommendations injury prevention pediatrics
monitoring message workflow transmission challenging problem especially pervasive environments mainly wide range unexpected events human material resources unavailability context changes source target localizations may occur run time paper propose information system services orchestration framework enabling intelligent message routing policy adaptation objective build reliable routing strategy autonomously intelligently adapt behavior decisions according source target context changes well controlled message status exceeded deadlines message reception present solution emphasizes cutting edge characteristics believe crucial enhancing quality message communication intelligence controllability scalability adaptivity personalization routing decisions adapted different levels decision making message itinerary delay message treatment etc means advanced methods detail sensitive self adaptive services
textile industry one largest sectors globally representing industrial water pollution however limited insight fluvial ecosystems respond recover impact summer spring examined water quality ecological status upstream downstream input textile industry wastewater treatment plant wwtp ripoll river spain ecological status determined via diversity measures biotic indices based diatoms macrophytes macroinvertebrates fish results showed wwtp severely deteriorated water quality biological communities discharge site improved downstream severity also varied across taxa seasons fish affected taxa spring season best ecological status strong correlation amongst water quality variables many biotic indices across taxa indicated chronic pollution event affecting multiple trophic levels thus study suggests urgent need invest wastewater treatment industry preserve ecological integrity ripoll river especially fish fauna likewise illustrates diagnostic power biotic indices based diatoms macroinvertebrates fish driven european water framework directive elsevier inc rights reserved
quantitative grain fluorescence quantitative grain fluorescence extract become effective approaches analysis hydrocarbon evolution clastic reservoirs recently cutoff threshold differentiating current paleo oil water zones crucial reconstruct accurately hydrocarbon accumulation history however absence theoretical study cutoff threshold carbonate reservoir precluded application development paper attempted investigate cutoff threshold analyzing quantitative grain fluorescence quantitative grain fluorescence extract parameters spectra cores natural carbonate outcrop samples known current paleo oil water zones revealed frequency oil inclusions formation test logging analysis etc based hydrocarbon charging history suqiao buried hill zone bohai bay basin eastern china reconstructed using gotten threshold results show carbonate minerals fluorescing lead higher cutoff threshold quantitative grain fluorescence index value carbonate reservoir threshold quantitative grain fluorescence extract intensity value coincident corresponding value clastic reservoir quantitative grain fluorescence quantitative grain fluorescence extract data unraveled complicated hydrocarbon accumulation history suqiao buried hill zone including oil charging gas paleo oil loss due tectonism ascertained cutoff threshold study great significance reconstructing accurately effectively complicated hydrocarbon charging history carbonate reservoir provides significant models future petroleum exploration
small selected samples approach combining resting state functional connectivity mri multivariate pattern analysis able successfully classify patients diagnosed unipolar depression purposes investigation assess generalizability approach large clinically realistic sample secondarily assess replicability previously reported methodological feasibility homogeneous subgroup pronounced depressive symptoms two independent subsets drawn depression control cohorts bidirect study patients controls without depression functional connectivity either among regions covering gray matter selected regions known alterations depression assessed resting state fmri support vector machines without automated feature selection used train classifiers differentiating individual patients controls entire first subset well subgroup model parameters explored systematically second independent subset used validation successful models classification accuracies large heterogeneous sample ranged chance level subgroup higher depression severity three models performed significantly chance independent validation conclusion common classification methods previously successful small homogenous depression samples immediately translate realistic population future research develop diagnostic classification approaches depression focus specific clinical questions consider heterogeneity including symptom severity important factor
work explored microwave absorption capabilily graphene oxide graphene oxide coaled fecob stealth technology epoxy based microwave absorbing materials prepared loading graphene oxide fecob alloy graphene oxide coated fecob graphene oxide fecob synthesized hummer precipitation methods respectively tiller particles characterized fesem xrd vibrating sample magnetometer techniques permittivity permeability reflection loss values composite absorbers measured vector network analyzer showed reflection loss value ghz single layered graphene oxide epoxy based microwave absorbers correlated absorption incident microwave energy reflection loss value fecob epoxy based microwave absorber showed ghz corresponded maximum absorption however reflection loss values graphene oxide coated fecob epoxy based single layer absorber increasecl ghz corresponds absorption incident microwave energy elsevier rights reserved
oral anticoagulant therapies antivitamin drugs avk warfarin acenocoumarol phenprocoumon employed primary secondary anti thrombotic prophylaxis patients venous thromboembolism atrial fibrillation cardiac mechanical valves however monitoring test international normalized ratio inr required periodic monitoring therapy entails discomfort patients telemedicine telecare provide significant aid management therapy allowing patients perform test home anywhere else portable device point care testing poct send result thrombosis via web patients receive dose adjustment sent back effectiveness type management equal superior traditional avk monitoring terms hemorrhagic thrombotic events analysis costs horizon years reveals self testing self management cost effective aim overview describe pros cons use poct alternative monitoring avk particular description poct decentralization quality therapy safety costs examined
paper presents novel robust color image zero watermarking scheme based svd visual cryptography firstly generate image feature svd image blocks employ visual secret sharing scheme construct ownership share watermark image feature low frequency component one level discrete wavelet transform color image partitioned blocks propose use feature generated first singular value blocks construct master share ownership debate occurs ownership share used extract watermark experimental results show better performance proposed watermarking system terms robustness various attacks including noise filtering jpeg compression visual cryptography based color image watermarking algorithm
objectives sources immunization data include state registries immunization information systems iis medical records surveys little known quality data sources feasibility using iis data research assessed feasibility collecting immunization information national children health study accessing existing iis data comparing completeness data medical record abstractions mra parent report staff time needed obtain iis mra data assessed methods administered questionnaire state level iis representatives ascertain availability completeness data research gather information data formats evaluated quality data iis medical records reports parents national children study participants three locations results iis data comparable mra data complete parental report agreement iis mra data greater parental report mra suggesting iis mra better sources parental report obtaining iis data took less staff time chart review making iis data linkage research preferred choice conclusions iis survey results indicate data obtained researchers using data linkages iis accessible feasible child immunization information source registries reduce reliance parental report medical record abstraction researchers seeking link iis data large multi site studies consider acquiring iis data may need strategies overcome barriers data completeness linkage
objective emerging data shown increased risk malignancy among patients diagnosed systemic sclerosis ssc identification risk factors linking disorders might prognostic implications aim study assess clinical treatment related risk factors cancer single center cohort patients ssc methods demographic clinical capillaroscopic immunological treatment related data consecutive ssc patients retrospectively analyzed variables reached significant association univariate analysis entered logistic regression order identify independent risk factors cancer results malignancy diagnosed patients fifty eight neoplasms identified among breast lung hematologic malignancies prevalent patients diagnosis scleroderma tumour made years apart cancer significantly decreased probability survival association age sex smoking cutaneous subset rna polymerase iii antibodies found however risk cancer directly associated presence anti scl antibodies inversely related aspirin use remained independent risk factors cancer multivariate analysis conclusions scl antibodies seemto associated higher risk cancer scleroderma contrast use aspirin related lower risk cancer series studies needed ascertain role anti scl antibodies aspirin development malignancy among patients ssc elsevier rights reserved
integrative literature review analyzed scientific knowledge produced orientation brazilian basic care services primary health care focusing child health searches carried scielo lilacs medline databases using descriptors primary health care family health program child health evaluation health services studies published portuguese english spanish selected total studies chosen characterized relation features primary health care region country type study authors practice area thematic review studies conducted resulted two categories child care context brazilian primary health care primary health care features limitations child care understood brazilian primary health care services heterogeneous regarding presence scope essential child care characteristics lack structural process changes services substantially plan child care actions basic care
introduction study aimed evaluate impact angiosome targeted direct revascularisation according revascularisation method patients diabetes materials methods retrospective study cohort comprised diabetic patients critical limb ischaemia tissue loss rutherford patients underwent infrapopliteal endovascular pta open surgical revascularisation january december differences outcome direct revascularisation bypass surgery pta investigated means cox proportional hazards analysis endpoints wound healing leg salvage amputation free survival results overall ischaemic wounds healed year follow highest wound healing rate achieved direct bypass worst indirect pta cox proportional hazards analysis showed number affected angiosomes atrial fibrillation number affected angiosomes significantly associated poor leg salvage direct pta associated lower rate major amputation compared indirect pta conclusion diabetics indirect endovascular revascularisation leads significantly worse wound healing leg salvage rates compared direct revascularisation therefore endovascular procedures targeted according angiosome concept bypass surgery however concept less value artery best runoff selected outflow artery european society vascular surgery published elsevier ltd rights reserved
clinical assessment immediate brace effect braces designed using cad cam fem cad cam conservative treatment ais using randomized blinded controlled study design forty ais patients prospectively recruited randomized two groups patients control group brace designed using scan patient torso conventional cad cam approach ctrlbrace patients test group brace additionally designed using finite element modeling fem reconstructions spine rib cage pelvis newbrace newbrace design simulated iteratively optimized maximize correction minimize contact surface material groups comparable age sex weight height curve type severity scoliosis research society standardized criteria bracing followed average cobb angle prior bracing degrees degrees main thoracic lumbar curves respectively control group degrees degrees test group ctrlbraces reduced curves degrees degrees respectively compared degrees degrees newbraces simulated difference inferior degrees newbraces thinner less covering surface ctrlbraces braces designed cad cam fem simulation efficient lighter standard cad cam tlso first immediate brace evaluation results suggest long term effect bracing ais may improved using new platform brace fabrication nct
precision ultrasonic measurements binary gas systems provide continuous real time monitoring mixture composition flow using custom microcontroller based electronics developed sonar instruments numerous potential applications capable making continuous high precision sound velocity measurements instrument measures sound transit times along two opposite directions aligned parallel obliquely crossing gas flow difference two measured times yields gas flow rate average gives sound velocity compared sound velocity molar composition look curves obtain binary mixture given temperature pressure look curves may generated prior measurements known mixtures two components theoretical calculations combination two describe instruments performance within numerous applications atlas experiment cern large hadron collider lhc instruments interest areas continuous situ binary gas analysis flowmetry required
paper presents empirical study based set measures evaluate usability mobile applications running different mobile operating systems including android ios symbian aim evaluate empirically framework developed use software quality standard iso mobile environments especially usability characteristic users participated experiment used iso iso standards objective measures working two widely used mobile applications google apps google maps quis questionnaire used collect measures assessing users level satisfaction using two mobile applications analyzing results highlighted set mobile usability issues related hardware well software need taken account designers developers order improve usability mobile applications
simple optoelectronic regenerator differential quadrature phase shift keying qpsk signals demonstrated regenerator consists two parallel delay interferometers followed balanced detectors limiting driving amplifiers dual parallel mach zehnder modulator regenerates noise suppressed optical qpsk signals experimentally show regenerator improves receiver sensitivity input optical signal noise ratio osnr signal speed gbaud numerical simulation conducted higher speed operation gbaud study impact bandwidth electrical circuits inside regenerator regenerator performance electrical power consumption regenerator assessed shown optoelectronic regenerator consumes similar amount electrical power consumed optical version regenerator using semiconductor optical amplifiers nonlinear element
previous studies demonstrated histone acetylation modulated transcription associated gene expression thus contributed persistence addictive behaviors neuroplasticity nonetheless roles histone acetylation distinct phases methamphetamine meth induced conditioned place preference cpp remain unclear current study examines effects histone deacetylases hdacs inhibitor sodium butyrate nab acquisition extinction reinstatement meth induced cpp mice results showed meth induced cpp mice four conditioning sessions meth induced cpp extinguished three extinction training sessions could triggered dose meth reinstatement test day meanwhile nab per effect natural preference mice injections nab conditioning extinction phases facilitated acquisition extinction meth induced cpp respectively additionally although effect single nab injection prior trigger cpp reinstatement observed repeated nab injections extinction phase totally blocked reinstatement meth induced cpp taken together results suggested specific effect histone acetylation modulating distinct phases meth induced cpp treatment nab extinction phase produced beneficial effects eliminating already established cpp also blocked reinstatement meth induced cpp wiley periodicals inc
year old male patient permanent testosterone therapy hypogonadism presented abdominal pain increased blood pressure values physical examination plethora noted laboratory examinations revealed polyglobulia subsequent diagnostic process polycythemia vera cancer could excluded cause secondary polyglobulia due testosterone substitution diagnosed unphysiologically high testosterone levels represent rare cause secondary polyglobulia appropriate medical history taken account early stage
maternal education differences children academic skills strongly linked parental investment behaviors study extended line research investigate whether maternal education patterns parenting observed among set parenting behaviors linked young children health drawing data early childhood longitudinal study birth cohort longitudinal models incorporating random effects authors found higher levels maternal education associated advantageous health investment behaviors phase early development months years years years moreover disparities typically largest developmental stage potentially sensitive children long term health development findings provide evidence developmental gradient associated mothers education new insight salience mothers education short long term health well children
use virtual reality environments power substations offers new paradigm supervisory control existence tridimensional model geometrically compatible real substation minimizes difference mental model constructed field operators control room improving communication additionally virtual environments may used simulators training environments nevertheless development process related applications quite complex including activities computer programming modeling usability studies significant managing tasks paper presents new software layers make development virtual power substations easier providing tight integration traditional cad software engines tools presented successfully applied construction several virtual electric power substations
alzheimer neurodegenerative disease affecting large populations worldwide characterized mainly progressive loss memory along various symptoms foremost cause disease still unclear however various mechanisms proposed cause disease include amyloid hypothesis tau hypothesis cholinergic hypothesis addition genetic factors various genes known involved apoe psen psen app among others present study used computational methods examine pathogenic effects non synonymous single nucleotide polymorphisms snps associated abca msaa cdap psen psen app genes snps obtained dbsnp database followed identification deleterious snps prediction functional impact prediction disease associated mutations performed impact mutations stability protein carried study structural significance computationally prioritized mutations proteins molecular dynamics simulation studies carried analysis snps ids abca msaa cdap psen psen app predicted deleterious disease associated significant structural impact proteins current study proposes precise computational methodology identification disease associated snps wiley periodicals inc
purpose retrospective study report clinical radiological outcome total hip arthroplasty patients previous hip arthrodesis retrospectively reviewed hips prospectively followed patients ankylosed hips converted total hip arthroplasty tha institution average age time conversion operation years range ankylosis lasted years range conversion surgery etiology ankylosis septic arthritis post traumatic hip osteoarthritis developmental hip dysplasia rheumatoid arthritis primary osteoarthritis ankylosing spondylitis hips indications arthroplasty intractable low back pain hip pain ipsilateral knee pain patients harris hip score hhs used rate clinical results surgery radiographic evaluations included component malposition loosening complications study period recorded mean follow period months range mean preoperative hhs range mean hhs final follow range statistically significant increase hhs hhs excellent good fair poor patients increase hhs lower points one patient points one patient required two staged exchange procedure due deep infection thus according success criteria increase hhs points radiographically stable implant surgical reconstruction patients benefit surgery trendelenburg sign positive hips limb length inequality patients mean range patients heterotopic ossification sciatic nerve palsy dislocation five intra operative fractures greater trochanter treated cable wiring one patient trochanteric avulsion injury treated trochanteric grip cables one patient deep infection one year conversion tha treated two staged exchange procedure conversion hip arthroplasty effective treatment method provides functional recovery patient satisfaction however proper surgical technique planning necessary minimize complications
descriptive study carried determine factors affecting health promoting behaviors nursing students sample consisted students questionnaire factors affecting lifestyle behavior health promotion lifestyle profile scale used collect data nursing students spring semester academic year significant difference found students without diagnosed health problems terms mean scores health promotion lifestyle profile scale subscales health responsibility spiritual growth interpersonal relations well total mean scores exercise nutrition spiritual growth stress management subscale scores students regularly going health checks determined significantly higher students obtain regular health checks students healthy lifestyle behaviors generally found medium level study provides evidence need interventions help nurses turkey
power upshift control automatic transmissions significant effect shift quality complex paper aims investigate relationship limited motor torque control performance power upshift control electric vehicles first simplified model electric vehicle powertrain general two speed automatic transmission built power upshift control strategy introduced powertrain model aim constant output torque power upshifts control strategy fully utilized control flexibility electric motors specifically focused effects limited motor torque control power upshifts simulation results demonstrated proposed control strategy could significantly improve shift quality electric vehicles mild driving conditions however performance proposed control strategy aggressive driving conditions impaired limited motor torque control effective solution proposed improve performance power upshift control aggressive driving conditions work may helpful improve shift quality electric vehicles internal combustion engine vehicles automatic transmissions
background objective study identify common aetiology bronchiectasis patients undergoing hrct chest navi mumbai understand demographical profile anatomical distribution bronchiectasis patients materials methods study included patients within age group years undergone hrct chest variety chest symptoms breathlessness cough haemoptysis fever without chills patients scanned using slice toshiba aquilion machine scans done supine position inspiratory scans thick sections taken intervals lung apices angles mas kvp parameters used expiratory scans except interval taken results study male female ratio found cause bronchiectasis patients study found post infectious koch commonest followed staphylococcus infection uip fungal infection cop left lung commonly involved followed right lung bilateral involvement upper lobes commonly involved followed lower lobes middle lobe involvement associated findings included tree bud appearance cases air space consolidation cases mucous plugs cases pleural effusion cavity cases conclusion important perform hrct symptomatic cases suspected bronchiectasis hrct sensitive modality showing bronchiectasis characterised lack bronchial tapering bronchi visible peripheral lungs increased broncho arterial ratio producing signet ring sign bronchiectasis caused complex cycle repeated inflammation defective immune response suppress haemoptysis common usually sequelae tuberculosis commonly bronchiectasis results necrotising bacterial infections study koch infection evolved common cause bronchiectasis
remote sensing observations extensively used analysis environmental variables variables often exhibit spatial correlation accounted calibration models used predictions either direct modelling dependencies allowing spatially correlated stochastic effects another feature many remote sensing instruments derived predictor variables highly correlated lead unnecessary model training worst singularities estimates affect prediction accuracy especially training set model calibration small overcome modelling challenges present general model calibration procedure remotely sensed data apply airborne laser scanning data forest inventory use linear regression model accounts multicollinearity predictors principal components bayesian regularization spatial random effect component spatial correlations explained simple linear model efficient markov chain monte carlo sampling scheme used account uncertainty model parameters tested proposed model several alternatives outperformed linear calibration models especially spatial effects multicollinearity training set size small authors published elsevier inc
long time russian historiography avoiding controversial intricate episodes civil war russia due specifics conformist nature episodes include among others problem effort unification regular army rkka workers peasants red army insurgent partisan forces western siberia elimination anti bolshevik regime admiral kolchak november january development vector process largely determined personal factor namely commander army red lett genrich eiche objective article consider specifics eiche personal interaction insurgent troops evolution views regarding problem using partisan forces context military actions conducted army leading within western siberia framework resource base research materials number russian archives russian state military archive state archive novosibirsk oblast state historical museum introduced academic circulation first time ever archive documents published earlier regional subject digests sense special attention justly paid operative documentation army directorship memoirs eiche major antagonist one leaders altai partisans zhigalin based complex materials author succeeded reconstructing actions eiche undertook verge implement insurgent forces western siberia one hand source march reinforcements army suffering combat losses typhoid outbreak hand strike advance force rkka siberia full participant military actions however due number reasons discussed article attempts part commander army generally failed particular attention focused unsuccessful experience eiche direct vicariously military actions insurgent groups altai yenisei provinces russia failed execute operative orders army commander finally particular experience underlined general mental disappointment eiche potential fighting moral qualities partisan movement western siberia negative feelings proved mutual later insurgent veterans talking eiche personality noted possessed biased attitude inveterate illness prejudice partisans present research enabled come conclusion negative perception partisans commander army indeed taken place however result arbitrariness prejudice instead quite well grounded many respects opinion military specialist
building design performance increasingly scrutinised perspectives sustainability hazard resistance however approaches taken consider perspectives disconnected green building rating systems consider hazard resistance assessments performance based engineering methods tended neglect consideration environmental impacts study presents framework assess building life cycle performance terms social environmental economic impacts using probabilistic approaches considering possible occurrence earthquake extreme event framework illustrated case study office building los angeles designed without different types vegetated green roofs risk varying earthquake hazard scenarios case study results demonstrate trade offs upfront building costs material choices hazard resistance environmental impact
objective reports concerning treatment combinations mood stabilizer antidepressant drugs based west surveyed characteristics cotreatment sites caring mentally ill asian countries methods cross sectional pharmacoepidemiologic study used data reap research study asian psychotropic prescription patterns antidepressants evaluate rates doses mss given ads associated factors psychiatric patients using standard bivariate methods followed multivariable logistic regression modeling results use increased much associated diagnosis bipolar disorder major depression anxiety disorder well hospitalization outpatient care psychiatric general medical programs young age country sex dose conclusions findings provide broad picture contemporary use mss ads asia support predictions treatment increased recent years associated diagnosis bipolar disorder treatment inpatient psychiatric settings younger age
scalability systems essential scenarios lot concurrent users systems peak access certain times others lot concurrent users regularly thus systems must able perform equally growing number requests study system scalability manipulate database considers read operations database systems however paper present approach horizontal scalability systems perform write database operations proposed approach uses queueing theory differs commonly developed solutions like clustering databases elasticity cloud case study conducted application persistent logs two versions application implemented order compare efficiency use queues results show efficiency use queueing theory implemented allow scalability applications large amount writing database operations
background paucity evidence regarding effects non vitamin antagonist oral anticoagulants noacs underweight patients atrial fibrillation objective purpose study evaluate efficacy safety noacs underweight patients methods analyzed patients prescribed noacs according body mass index bmi underweight bmi analyzed association clinical outcomes bmi results median months interquartile range months follow major bleeding events thromboembolic events deaths risks major bleeding cause death significantly higher group compared group adjusted hazard ratio confidence interval adjusted group adjusted adjusted however significant difference risk thromboembolism among groups conclusion patients taking noacs underweight associated increased risk major bleeding cause death compared normal weight overweight obese whereas risk thromboembolism different dose reduction considered underweight patients high risk bleeding
sidonian sarcophagus late antique early christian period skeletal remains two persons found one male years old found almost completely ankylosed highly osteoporotic bones prominent erosion joint surfaces diagnosed rheumatoid arthritis based eroded odontoid process mandibular condyles distal humerus proximal distal ulna well ankylosed hand foot bones despite fact ankyloses vertebrae sacroiliac joint could point towards ankylosing spondylitis lack typical vertebral ankyloses new bone formation led exclusion practical sense due advanced stage disease man fixed supine position left head turned right apparently could move problems chewing breathing high standard provided healthcare probably enabled survive advanced stages disease case shed light antiquity disease medical social context provided example extreme osteological changes reported paleopathological medical literature
article summarizes literature regarding epidemiology prevention unintended pregnancy united states affordable care act accompanying contraceptive provision need primary care clinicians provide family planning services office based interventions incorporate family planning services primary care presented including clinical tools electronic health record use special attention paid long acting reversible contraceptive methods subdermal implant intrauterine devices highly effective safe methods greatest potential decrease rate unintended pregnancy underused
aim work study thermal flux multilayer insulation specimen whose final panels could designed green building field specimen fabricated using expanded styrofoam base mortar milk cements fiberglass hemp fibers chopped scattered surface smoothing dimensions specimen need analyze reduced surface development visualization follows computational aspect limit number degrees freedom solved specifically research focused comparative analysis among numerical simulations data processing means matlab using finite difference method fdm domain comsol multiphysics using finite element method fem domains addition experimental analysis centred detecting sub superficial fiberglass means infrared thermography irt technique carried specific matlab script also implemented finally observed comsol multiphysics allows visualization flow done matlab also entire specimen geometry possibility realizing video thermal transient heating cooling phases
recent studies demonstrate veterans exhibit higher suicide risk compared general population prior suicide attempt well documented predictor suicide death despite increased attention clinical risk factors suicide efforts develop psychosocial interventions reduce suicide risk underlying biological factors confer risk well understood study examined affect modulated startle ams series intermixed unpleasant neutral pleasant pictures sample demographically matched veterans low passive ideators high risk active ideators single attempters multiple attempters suicide based columbia suicide severity rating scale exploratory aim involved longitudinal component subset high risk sample went participate randomized month clinical trial investigated whether baseline ams predicts subsequent suicide attempt month follow compared three groups multiple attempters showed greater startle potentiation unpleasant pictures deficient overall startle habituation early later trials groups differ startle neutral pleasant pictures self reported picture valence greater startle unpleasant pictures associated greater emotion dysregulation measured difficulties emotion regulation scale future suicide attempt assessed prospectively month follow findings suggest startle potentiation unpleasant pictures multiple suicide attempters promising psychophysiological biomarker suicide risk underscore clinical importance targeting emotion dysregulation treatment patients risk suicide
earthquake freestanding equipment contents building may experience large complex motion depending geometry mass distribution support mechanism wheels casters legs object motion may include rolling sliding twisting rockingpotentially resulting overturning impact building occupants neighboring walls objects measuring complex motion traditional contact type displacement sensors challenging owing recent advances video capture sensors image processing techniques vision based motion tracking measurement introduced practical economical fairly accurate measuring method paper presents procedure utilized evaluate accuracy consumer grade camera purpose measuring motion piece medical equipment shake table testing fixed focal length camera considered study capture video recordings different resolution frame rates experimental testing camera positioned distance target would real application track motion four led lights attached shake table capabilities camera evaluated using input signal varying frequency amplitude wavelet approach proposed utilized order synchronize vision based displacement measurement output displacement transducer installed shake table later used accuracy assessments absolute relative error curves presented evaluate errors frequency range interest actual experiments finally contour plots proposed specify displacement velocity acceleration accuracy vision based measurements used future applications american society civil engineers
litopenaeus vannamei juveniles initial density individuals grown days cylindrical tanks water exchange three tanks aquamats promote periphyton growth six geotextile fabric mosquito net three substrate remaining three served controls shrimp fed protein shrimp feed twice daily supplied demand differences dissolved tan unionized ammonia concentrations treatments substrates significantly lower control values higher tanks substrates possibly indicating faster nitrification rates tanks produced shrimp higher mean individual weights growth rates control final yield tanks mosquito netting intermediate control remaining treatments highest feed economic feed conversion indices lowest nitrogen utilization protein efficiency ratio control differences three treatments added substrates showing less expensive geotextile fabric mosquito net may used efficiency aquamats periphyton based aquaculture
intestinal glycoprotein regio selectively expressed high affinity low capacity efflux carrier cationic poorly permeable trospium organic cation transporter oct provides lower affinity higher capacity trospium uptake evaluate regional intestinal permeability absorption profiles gastric infusion trospium chloride swallowing immediate release tablets fasted fed healthy subjects evaluated using inverse gaussian density function model input rate mean absorption time mat trospium chloride slowly absorbed mat similar gastric infusion involving two processes different input rates peaking input rates mat influenced dosage form meal conclusion trospium absorbed two windows located jejunum cecum ascending colon whose uptake capacity might result local abundance functional interplay glycoprotein oct elsevier rights reserved
rapid development mobile communications technologies social apps line wechat emerged important communication tools although social apps provide people additional convenience overuse applications may negative life effects technostress distraction past research indicated personality attributes contribute compulsive usage study explores relationships personality attributes compulsive usage social apps examines impact technostress academic performance total valid questionnaires collected university students online survey fourteen proposed hypotheses examined using smartpls software results indicate extraversion agreeableness neuroticism significant effects compulsive usage mobile social applications compulsive usage significant positive impact technostress negatively affect academic self perception course grades addition conscientiousness significantly influenced academic self perception unexpectedly gender number friends little influence technostress compulsive usage implications findings discussed directions future research offered elsevier ltd rights reserved
novel monobloc design two degree freedom dof compliant tool tip handheld powered surgical tool presented paper monobloc tool tip pitch yaw using corner filleted flexure hinge based compliant joints integrated compliant grasper dof tool tip realized six compliant joints placed alternating fashion orthogonal tool externally powered consists drive box stainless steel tube compliant tool tip distal end drive box houses thumb joystick command input three servo actuators microcontroller microcontroller maps surgeon command input tool tip orientation grasper actuation design graspers tool tip actuated tensile forces conveyed tethers exert compressive load dof compliant joints since compressive load carrying capacity slender flexure based compliant joints limited design enhance compressive loadcarrying capacity compliant joints circular guide presented finite element simulation done verify design compliant joints experiments carried assess relationship force input servo actuators joint deflection additional experiments carried determine maximum pinching force exerted compliant graspers prototype complete surgical tool built demonstrate utility proposed compliant tool tip alternative traditional tool tip handheld powered surgical tool
letter introduces efficient technique pulse compression dispersion compensation using microwave chirped pulses propagating metamaterials negative refraction regime accomplish investigated infinitely wide cells thick metamaterial slabs using finite difference time domain method parameter extraction technique demonstrate controlling chirp initial pulse association metamaterial cell density geometry frequency response possible compress pulse factor also compensate pulse broadening due chromatic dispersion
people autism spectrum disorder asd difficulties identifying another person face voice might contribute considerably development social cognition interaction difficulties characteristics voice recognition deficit asd unknown used comprehensive behavioral test battery systematically investigate voice processing high functioning asd typically developed pair wise matched controls asd group particular difficulties discriminating learning recognizing unfamiliar voices recognizing famous voices relatively intact tests acoustic processing abilities showed asd group specific deficit vocal pitch perception dissociable otherwise intact acoustic processing musical pitch musical vocal timbre perception results allow characterization voice recognition deficit asd findings indicate high functioning asd difficulty recognize voices particularly pronounced learning novel voices recognition unfamiliar peoples voices pattern might indicative difficulties integrating acoustic characteristics voice coherent percepta function previously associated voice selective regions posterior superior temporal sulcus gyrus human brain autism res international society autism research wiley periodicals inc
limited research traditional hispanic male female gender roles machismo marianismo respectively relation negative cognitions emotions given vulnerability hispanics negative cognitions emotions important examine sociocultural correlates emotional distress therefore examined associations machismo marianismo negative cognitive emotional factors depression symptoms cynical hostility trait anxiety anger hispanic community health study study latinos hchs sol sociocultural ancillary study cross sectional cohort study sociocultural psychosocial correlates cardiometabolic health participants aged years self identified hispanic central american cuban dominican mexican puerto rican south american hispanic background results revealed specific components machismo traditional machismo marianismo family spiritual pillar dimensions associated higher levels negative cognitions emotions adjusting sociodemographic factors associations remained consistent across sex hispanic background group acculturation findings inform mental health interventions contribute understanding importance gender role socialization context self reported negative cognitive emotional factors hispanics
explore demographics clinical medication profiles patients social support perceived health status hiv coinfected patients guangxi china performed cross sectional study hiv clinic guigang city people hospital health professionals conducted face face interviews collected data patients electronic medical records regarding patients demographic clinical medication information well social support perceived health status classified hiv aids patients hiv monoinfected coinfected ratio ompared hiv monoinfected patients hiv coinfection likely older male less educated unemployed carrying health insurance advanced stage hiv infection longer history hiv opportunistic infections patients coinfected also likely hold negative belief hiv treatment could prevent exacerbations reported significantly worse emotional informational support social interaction perceived health status better social support better self efficacy hiv treatment adherence significantly associated better perceived health status among patients hiv coinfection hiv coinfection associated poorer perceived general well mental health particularly undergoing therapy findings suggest need mental health referrals medication management coinfected individuals well efforts policies improve coordinated care
stage tibial osteotomy may deserve consideration candidates total knee arthroplasty tka severe bone deformities particularly extra articular sites strategy obviates need either major technically difficult ligament release procedure may compromise ligament balancing use semi constrained prosthesis technical note describes one stage computer assisted technique consisting tka followed corrective tibial osteotomy obtain overall mechanical axis close without extensive ligament balancing technique provided satisfactory outcomes patients followed least years specific complications ligament instability hip knee ankle angle close planning intra operative computer assistance ensures accurate determination implant position degree correction achieved osteotomy elsevier masson sas rights reserved
propose ultra broadband super light absorber integrating different sized tapered hyperbolic metamaterial hmm waveguides different wide absorption band due broadband slow light response unit cell numerically demonstrate absorber superior single sized hmm absorber terms absorption bandwidth maintaining comparable absorption efficiency three different sized hmm absorber presents capability working ultra wide frequency band ranging thz much larger previously proposed absorbers working spectral region design shows great promise broad range applications thermal emitters photovoltaics optical chemical energy harvesting stealth technology ultra wideband absorption high demand
cosivu three year collaborative research project ended september funded within european green car initiative european green vehicle initiative cosivu addresses one critical technical parts fully electrical vehicles fev besides energy storage system mechatronic drive train unit cosivu project delivered new system architecture multiple wheel drive trains smart compact durable single wheel drive unit integrated electric motor full silicon carbide sic power electronics switches diodes novel control health monitoring module wireless communication advanced ultra compact cooling solution dfr utilizing fem simulations ensures first time right solutions paper presents main results including architecture drive train solution well modular design inverter based inverter building blocks one per phase performance tests presented first time heavy duty commercial vehicle solution performed test rig volvo tests cosivu solution adapted passenger car done elaphe
objective one common complaints among postmenopausal women change sexual drive aim study assess current state sexual health spanish postmenopausal women present outpatient gynecology clinics method multicenter observational cross sectional questionnaire based study survey conducted included spanish postmenopausal women routine clinical setting outpatient gynecology clinics public private institutions throughout spain used women sexual function questionnaire validated spain results multivariate analysis found best indicators sexual health postmenopausal women higher education working previously worked stable partner living urban area healthy habits received information menopause conclusion results indicate important provide health education information menopause complaints associated period woman life
objectives hypothesis although geometry vocal fold medial surface affects voice quality critical treatment glottic insufficiency prephonatory shape vocal fold medial surface well understood study activated intrinsic laryngeal muscles individually combinations recorded temporal sequence precise three dimensional configurational changes vocal fold medial surface study design vivo canine hemilarynx model methods hemilaryngectomy performed vivo canine model ink used mark medial surface situ vocal fold grid like fashion thyroarytenoid lateral cricoarytenoid lca cricothyroid posterior cricoarytenoid pca muscles stimulated individually combinations right angle prism whose hypotenuse formed glottal midline provided two distinct views medial surface high speed digital camera image processing package davis lavision inc goettingen germany allowed time series cross correlation analysis three dimensional deformation calculations vocal fold medial surface results combined lca activation yields evenly adducted rectangular glottal surface addition thyroarytenoid cricoarytenoid adducts vocal fold inferior superior graded fashion allowing formation divergent glottis posterior cricoarytenoid bimodal relationship thyroarytenoid favoring abduction cricothyroid lateral cricoarytenoid yield unique glottal postures necessary likely conducive efficient phonation conclusions understanding three dimensional geometry vocal fold medial surface help better understand cause effect relationship laryngeal physiology phonation
phosphorylated alpha synuclein alpha syn deposits one neuropathological hallmarks parkinson disease recently detected dermal nerve fibres patients good specificity sensitivity studied whether alpha syn may serve biomarker patients high risk developing rem sleep behaviour disorder rbd compared presence distribution alpha syn deposits dermal nerve fibres patients rbd patients early normal controls skin biopsy taken upper lower leg presynaptic dopamine transporter imaging using cit spect performed patients rbd patients rbd patients underwent olfactory function testing likelihood ratio prodromal calculated patient based published research criteria skin serial sections assessed double immunofluorescence labelling antibodies pser alphasyn blinded conditions alpha syn visualized patients rbd sensitivity early patients sensitivity none controls specificity percentage dermal structures innervated alpha syn positive fibres negatively correlated dopamine transporter binding cit spect rho olfactory function rho positively correlated total rbd present prodromal rho dermal alpha syn considered peripheral histopathological marker synucleinopathy detected subgroup rbd patients presumably representing prodromal dermal alpha syn detectable rbd patients without motor symptoms thereby stratifying patient group great interest clinical trials testing disease modifying drugs
paper investigate stability positive negative feedback interconnections linear system duhem hysteresis operator provide sufficient conditions linear plant duhem operator based counterclockwise ccw clockwise input output property plant hysteresis operator show application main result design linear controller stabilize simple mechanical system driven hysteretic actuator piezo actuator smart material based actuator elsevier ltd rights reserved
background programmed cell death protein blockade therapies demonstrated durable responses prolonged survival variety malignancies treatment generally well tolerated although immune related adverse events iraes occur autoimmune thyroid dysfunction among common irae assessment clinical mechanistic immunologic features previously described patient methods patients advanced non small cell lung cancer nsclc treated pembrolizumab memorial sloan kettering cancer center part keynote nct included thyroid function test antithyroid antibodies assessed prospectively study visit beginning first treatment frequency development thyroid dysfunction association anti thyroid antibodies clinical course relationship progression free survival overall survival treatment pembrolizumab evaluated results patients treated hypothyroid baseline ten confidence interval patients developed thyroid dysfunction requiring thyroid replacement anti thyroid antibodies present patients developed thyroid dysfunction compared versus thyroid dysfunction occurred early median days pembrolizumab course majority patients experienced brief transient hyperthyroidism preceding onset hypothyroidism persistent hyperthyroidism occurred hyperthyroidism hypothyroidism largely asymptomatic overall survival pembrolizumab significantly longer subjects developed thyroid dysfunction hazard ratio conclusions thyroid dysfunction pembrolizumab treatment nsclc common characterized early onset frequently preceded transient hyperthyroidism closely associated anti thyroid antibodies may associated improved outcomes presence antibody mediated toxicity cell directed therapy suggests recognized impact biology modulating humoral immunity
modeling electrochemical impedance spectroscopy usually done using equivalent electrical circuits circuits parameters need estimated properly order make possible simulation impedance data despite fitting procedure optimization problem solved recurrently literature rarely statistical significance estimated parameters evaluated work optimization process equivalent electrical circuit fitting impedance data detailed first mathematical development regarding minimization residual least squares presented order obtain statistically valid objective function complex nonlinear regression problem optimization method used work presented differential evolution global search stochastic method furthermore shown population based stochastic method like used directly obtain confidence regions estimated parameters sensitivity analysis also conducted finally equivalent circuit fitting done model synthetic experimental data order demonstrate adopted procedure elsevier rights reserved
tinnitus ringing ear characterized perception sound absence corresponding acoustic stimulus many affected people habituate phantom sound others severely bothered impaired quality life assumed latter group characterized deficient noise cancelling mechanism brain train tinnitus patients focus target sounds hence suppress irrelevant background sounds developed mobile serious game application presented paper application runs three mobile operating systems describe goals architecture well results evaluation study study results indicate gaming approach feasible training affected patients focusing directional hearing thereby suppress tinnitus compared traditional hearing training advances approach anytime availability higher enjoyment immediate feedback option stepwise increase game difficulty expected increased patient motivation adherence well improved training learning effects
consider two new matrix spectral problems construct corresponding soliton hierarchies levi type aid symbolic computation maple means trace identity hamiltonian structures resulting soliton hierarchies obtained shown soliton hierarchies liouville integrable end paper
objective patients intermittent claudication often high blood pressure increases cardiovascular risk however whether walking capacity associated levels patients remains unknown therefore study designed investigate whether total walking distance associated ambulatory patients participants methods cross sectional study patients men women maximal treadmill test gardner protocol performed assess total walking distance patients furthermore ambulatory heart rate rate pressure product load obtained period one way analysis variance multiple linear regression carried results walking capacity correlated negatively following asleep systolic diastolic mean heart rate awake asleep rpp iii awake asleep systolic load associations occurred irrespective confounders age sex bmi smoking status number antihypertensive medications conclusion better walking capacity associated lower ambulatory parameters patients copyright wolters kluwer health inc rights reserved
interspecies differences anatomical physiological aspects wells simplified study designs contribute overestimation treatment effects limit transferability experimental results clinical applications confounders cell therapies cerebrovascular disorders cvd include common cvd comorbidities frequent medications potentially affecting endogenous transplanted stem cells well age immune system related effects contribute substantial modeling bias ultimately limiting prospective quality preclinical research programs regarding clinical value particular cell therapy review discuss nature impact relevant confounders provide suggestions considered enhance validity cvd models stem cell research acknowledging substantial sometimes surprising effects housing conditions chronobiology intersex differences augment translational value animal models finally discuss options implementation high quality functional imaging readout protocols altogether might help gain holistic picture therapeutic impact particular cell therapy cvd also potential side site effects intervention stem cells
objective spontaneous subaponeurotic fluid collection ssfc uncommon newly described entity unknown etiology observed infants less year age authors report series infants presented hospital sick children hsc ssfc focusing natural history condition methods data hospital sick children retrospectively reviewed period january june patient age sex birth history medical history laboratory findings symptoms reviewed ssfc location imaging characteristics management outcome also analyzed medline embase literature search performed condition yielding previously reported cases ssfc english language results nine cases involving patients presented ssfc study period identified patients male female infants age range weeks months cases ssfc developed spontaneously period days infants history injuries trauma hair manipulation immediate period preceding development subgaleal collections six patients underwent remote forceps vacuum assisted instrumented births although none patients developed scalp collections skin discoloration immediately birth cases managed conservatively outpatient cases inpatient cases basis case size fluid collection fluctuated months cases collections resolved spontaneously without structural infectious complications conclusions largest series describing ssfc date summarizes cases managed large academic neurosurgical center although specific pathophysiology ssfc remains unknown cases condition may associated remote history instrumented delivery ssfc occurs spontaneously without immediate preceding trauma extensive hematology child abuse workup necessary conservative approach outpatient follow advocated
active contour models acm widely used segmentation many computer vision applications models defined energy functional attached initial curve evolves constraints extract desired objects image new models proposed existing techniques investigated improved different domains among acm balloon acm edge based model adds normal force constraint making curve dynamic behaviors effectiveness detecting objects boundary however problems pointed including segmentation complex shape high runtime processing paper develop new method called fast adaptive balloon fab sufficient segment complex shape lower computational complexity proposed definition balloon force achieves satisfactory segmentation performance compared acms using synthetic medical images two dimension results demonstrate accuracy effectiveness segmentation besides convergence speed
objectives use oral contraceptive pills ocr increases risk cerebral venous sinus thrombosis cvst whether risk varies type duration forms hormonal contraceptives largely unknown systematic review meta analysis update current state knowledge methods performed search identify published studies association hormonal contraceptive use risk cvst women aged years results studies reviewed included pooled odds developing cvst women aged years taking ocps times higher compared women taking ocps data insufficient make conclusions duration use forms hormonal contraceptives conclusion oral contraceptive pills use increases risk developing cvst women reproductive age future studies required determine duration type hormonal contraceptives modify risk
objective examine association depressive symptoms contraceptive method choice among adolescents initiating prescription contraception study design cross sectional study analyzes baseline data urban minority adolescent females ages years presenting prescription contraceptive initiation comprehensive free cost adolescent health center new york city participants met health care provider provided standard contraception counseling initiating contraception participant selected short long acting contraceptive month supply pill patch ring medroxyprogesterone acetate depot injection short acting placement referral intrauterine device rid long acting assess independent association contraceptive method selection symptoms depression assessed center epidemiological studies depression ces scale results ten percent adolescent females selected iud bivariate analysis revealed elevated levels depressive symptoms likely select iud compared minimal symptoms mean ces score multivariate logistic regressions adolescent females increased odds selecting iud reported moderate severe depressive symptoms adjusted odds ratio confidence interval controlling ethnicity race education number lifetime partners gravidity conclusions inner city minority adolescents elevated symptoms depression present prescription contraceptive initiation may likely select iud rather shorter acting methods recognizing adolescent females depressive symptoms providers strategize approach effective contraception counseling elsevier inc rights reserved
objectives intimate partner violence ipv major problem could affect reproductive decision making aim study examine association ipv contraceptive use assess whether association varies receipt prenatal birth control counseling race ethnicity study design study analyzed national pregnancy risk assessment monitoring system prams included women live births united states ipv determined questions asked physical abuse current former partner months pregnancy outcome postpartum contraceptive use yes multiple logistic regression analyses conducted assess influence experiencing ipv different periods preconception ipv prenatal ipv preconception prenatal ipv preconception prenatal ipv data stratified assess differential effects race ethnicity receipt birth control counseling results approximately women reported ipv reported postpartum contraceptive use regardless timing abuse ipv exposed women significantly less likely report contraceptive use delivery particularly true hispanic women reported prenatal birth control counseling women racial ethnic groups received prenatal birth control counseling conclusions ipv victimization adversely affects use contraceptive methods following delivery women live births birth control counseling health providers may mitigate effects however quality counseling needs investigation better integration violence prevention services family planning programs greatly needed implications consistent national recommendations preventive service task force clinicians public health workers strongly encouraged screen ipv health providers educate women effective contraceptive options discuss long acting reversible contraceptives partner dependent within context abusive relationships elsevier inc rights reserved
background somatostatin analogue based radionuclide therapy dotatate important treatment option patients advanced neuroendocrine tumours overexpressing somatostatin receptors addition kidneys bone marrow major dose limiting organ correlation developed haematological toxicity absorbed dose bone marrow poor indicates factors affect haematological response spleen important role haematopoetic system including reservoir blood cells also organ receives highest mean absorbed dose dotatate treatment aim study analyse mean absorbed dose spleen correlation haematological toxicity explore changes splenic volume study included patients treated gbq gbq dotatate two five occasions following fraction planar whole body scans acquired spect post injection mean absorbed spleen dose calculated utilising planar images time activity data spect adjust activity amounts splenic volume information collected diagnostic scans baseline follow results median total absorbed spleen doses estimated respectively total absorbed spleen dose correlated decrease wbc plt counts patients without bone metastases mean absorbed spleen dose correlated decrease plt wbc counts spleen volume reduced original values mean followup months conclusions haematological toxicity according counts moderately significantly correlated total absorbed spleen dose supports possibility radiation exposure spleen affects overall haematological response dotatate treatment
timing introduction solid food subsequent development food allergy debate role concurrent breastfeeding unclear aim present study investigate role solid food introduction whilst concurrently breastfeeding food allergy outcome specific focus cows milk allergy prospectively collected infant feeding data birth cohort analysed participants histories suggestive food allergy underwent diagnostic food challenges children food allergy matched control participants age sex mann whitney tests chi fisher exact tests logistic regression calculations undertaken total thirty nine food allergic children seventy eight matched controls identified including twenty two cows milk allergic children forty four matched controls control group introduced solid food earlier food allergic group effect concurrent breastfeeding alongside cows milk introduction food allergens development food allergy due small numbers possible explore differences food allergy phenotype therefore found evidence introducing solids food allergens whilst breastfeeding allergy preventative effect however results interpreted caution due sample size recommendations regarding infant feeding food allergy carefully considered although breastfeeding promoted many health reasons larger studies looking introduction food allergens development food allergy needed make final conclusion
cardiovascular disease one leading causes death psoriatic arthritis psa pathogenesis accelerated atherosclerosis psa remains elucidated endothelial dysfunction often precedes manifesting atherosclerosis study aims assess carotid intima media thickness cimt marker atherosclerosis psa context markers inflammation vascular function cross sectional study performed psa patients compared controls matched age sex flow mediated dilatation fmd assessed angio defender everist health ann arbor endothelial progenitor cells epcs quantified flow cytometry cimt measured ultrasonographically inflammatory measures included disease activity score joints count disease activity index psoriatic arthritis also assayed markers inflammation including reactive protein crp erythrocyte sedimentation rate esr proinflammatory cytokines interleukin tumor necrosis factor tnf alpha endothelial dysfunction including lipids intercellular adhesion molecule icam vascular cell adhesionmolecule vcam epcs cimt significantly higher psa patients compared controls whereas fmd epcs high density lipoproteins hdl cholesterol significantly reduced psa compared controls compared controls psa patients significantly increased concentrations esr crp tnf alpha icam vcam psa cimt positively correlated icam inversely correlated fmd hdl epcs psa fmd cimt impaired indicating endothelial dysfunction accelerated atherosclerosis respectively psa related inflammatory mechanisms tnf alpha markers vascular function crp icam epcs may involved development vascular disease psa cytokine triggered inflammation upregulates expression adhesion molecules depletes epcs endothelial dysfunction increased cimt psa
two nonlinear analysis methods newly presented finding initial shape suspension bridges dead load extended tangential stiffness matrices nonlinear frame element well elastic catenary cable element derived adding unstrained element lengths unknown tcud generalized target configuration dead loads method unstrained element length method proposed get minimized bending moment well remove lateral axial deformations main girder tower finally accuracy effectiveness proposed schemes demonstrated two numerical examples elsevier ltd rights reserved
introduction autoimmune cytopenias aic including autoimmune hemolytic anemia aiha immunologic thrombocytopenia itp rare immunologic disorders scarcely reported inflammatory bowel diseases ibd conducted multicentric retrospective study including case control analysis aimed describe characteristics outcomes patients affected aic ibd method forty cases recruited ibd centers aic tertiary centers controls recruited micista registry results micista registry incidences estimated patient years patient years ibd diagnosis aiha itp respectively aiha patients colonic involvement whereas diagnoses evenly distributed among itp patients compared control ibd patients cases characterized higher frequency extra intestinal manifestations presence ibd severity hallmark aiha ibd ran mainly parallel aiha warm aiha isolated cases rituximab infliximab efficient treat ibd aic respectively ibd surgery may induce aic remission cases conclusion although low incidence aic appears higher ibd patients compared general population association seems mainly non fortuitous especially colitis associated aiha editrice gastroenterologica italiana published elsevier ltd rights reserved
significant challenge faced mobile application industry developing maintaining multiple native variants mobile applications support different mobile operating systems devices varying application functional requirements current industrial practice develop maintain variants separately potential change applied across variants manually neither efficient scalable consider problem supporting multiple platforms software product line engineering problem paper proposes novel application product line model driven engineering mobile application development addresses key challenges feature based native mobile application variants multiple platforms specifically deal three types variations mobile applications variation due operation systems versions software hardware capabilities mobile devices functionalities offered mobile application develop tool moppet automates proposed approach finally results applying approach two industrial case studies show proposed approach applicable industrial mobile applications potential significantly reduce development effort time elsevier inc rights reserved
magnetic resonance enterography mre increasingly relied upon noninvasive assessment intestinal inflammation crohn disease however studies examined diagnostic accuracy individual mre signs children created based multi item measure intestinal inflammation children crohn disease pediatric inflammatory crohn mre index picmi inform item selection instrument explored inter rater agreement diagnostic accuracy individual mre signs inflammation pediatric crohn disease compared findings reference standards weighted pediatric crohn disease activity index wpcdai reactive protein crp cross sectional single center study mre studies children diagnosed crohn disease male median age years reviewed two independent radiologists presence mre signs inflammation using kappa statistics explored inter rater agreement mre sign across anatomical segments gastrointestinal tract correlated mre signs reference standards using correlation coefficients radiologists measured length inflamed bowel segment gastrointestinal tract segment mre signs scored either binary absent present ordinal absent mild marked segmental scores weighted length involved bowel summed produce weighted score per patient mre sign using combination wpcdaiae crpae define active inflammation calculated area receiver operating characteristic curve auc weighted mre sign bowel wall enhancement wall hyperintensity wall thickening wall diffusion weighted imaging dwi hyperintensity commonly identified inter rater agreement best decreased motility wall dwi hyperintensity correlation mre signs wpcdai higher crp auc highest ulcers wall enhancement wall thickening wall hyperintensity wall dwi hyperintensity mre signs good inter rater agreement auc detection inflammation children crohn disease
year old male patient sustained isolated syndesmotic injury right ankle following fall complaints subsided gradually within first six weeks conservative treatment end third month returned follow posterior ankle pain radiological examinations revealed heterotopic ossification adjacent posterior inferior tibiofibular ligament posterior capsule complaints disappeared local excision ossification heterotopic ossification may cause persistent pain ankle ligament injuries
background physical activity support cancer patients medical treatment reducing side effects increasing quality life however levels mostly decline diagnosis factors explain patients able remain even increase level self efficacy important cognitive factor linked cancer patients across many studies contrast affective factors enjoyment rarely examined compare influence self efficacy enjoyment cancer patients levels completion exercise stress management intervention methods outpatient cancer patients female years breast colon cancer enrolled motivaction study week intervention counseling followed weekly phone calls pre test post test week follow participants randomized either exercise intervention emphasizing self regulatory strategies behavior change stress management intervention coping relaxation techniques sixty seven patients remained study completed squash assessment measure maintenance self efficacy items cronbach alpha enjoyment items cronbach alpha regression analyses calculated level dependent variable relative weight analyses conducted study registered clinicaltrials gov unique identifier nct url https clinicaltrials gov show nct term motivaction rank results baseline self efficacy change enjoyment significantly predicted cancer patients level adjusting baseline type intervention relative weight analysis revealed enjoyment baseline change together explained dependent variable self efficacy baseline change explained follow self efficacy still significant predictor whereas enjoyment longer relevant factor conclusion affective factor enjoyment equally important self efficacy predicting cancer patient level directly completion intervention reasons reduced relevance follow broader range affective factors analyzed future studies cancer patients level
acute coronary syndrome acs could precious opportunity patients reveal concealed diseases conventional risk factors acs hypertension dyslipidemia diabetes mellitus etc setting acs intracoronary systemic prothrombotic environment led increase risk stent thrombosis mortality higher among patients acs especially highest mortality patients elevation myocardial infarction specific conditions concealed beyond cardiovascular pathophysiology except well known risk factors acs stent thrombosis might involve onset acs describe case year old man admitted intensive care unit chest pain case found possibility polycythemia vera janus kinase jak mutation might underlying disease acs stent thrombosis highlighted importance recognizing polycythemia vera jak mutation concealed disease cardiologists would like report review relationship acs polycythemia vera jak mutation
study investigated potential adverse effects zinc oxide nanoparticles znosm nps zinc oxide nanoparticles positively charged pregnant dams embryo fetal development maternal exposure period gestational days sprague dawley rats znosm nps administered pregnant rats gavage day dams subjected cesarean section gestational day fetuses examined external visceral skeletal alterations toxicity dams manifested significantly decreased body weight administration day nps reduced food consumption administration day nps decreased liver weight increased adrenal glands weight administration day nps however treatment related difference number corpora lutea number implantation sites implantation rate resorption dead fetuses litter size fetal deaths placental weights sex ratio observed groups hand significant decreases treatment groups controls seen fetal weights administration day nps morphological examinations fetuses demonstrated significant differences incidences abnormalities group administered day meanwhile significant difference found content fetal tissue control high dose groups results showed oral doses study days repeated znosm nps maternotoxic day group embryotoxic day group
context troponin upstream open reading frame peptide tntuorf may useful novel biomarker acute cardiac syndromes objective study examined early release kinetics tntuorf materials methods analyzed time course release cardiac troponins tntuorf patients hypertrophic obstructive cardiomyopathy undergoing transcoronary ablation septal hypertrophy tash results fifteen minutes tash levels troponins increased significantly ctnt median versus ctni median versus tntuorf showed variation discussion observed significantly greater increase ctni compared ctnt conclusion results demonstrate troponin assays allow early detection myocardial injury whereas tntuorf levels remain unchanged setting
epidermal proliferation inflammatory changes microvascular augmentation prominent features chronic cutaneous psoriatic lesions objective study investigation blood lymphatic microvascular changes relation epidermal changes inflammatory infiltration dermis immunohistochemical analysis antibodies podoplanin vascular endothelial growth factorsa vegf morphometric software used quantification following parameters blood lymphatic vessel area bva lva vegf vegf positive area inflammatory cell infiltration dermis cia epidermal area comparison healthy skin psoriatic lesions showed remarkable elevation measured parameters following average increase bva times increased lva times increased vegf vegf area epidermis times times increased dermis times times increased respectively times increased statistical analysis revealed significant positive correlation cia psoriatic samples blood vessels area vegf expression epidermis showed mild positive correlation epidermal hyperplasia weak positive correlation dermal inflammatory infiltration vegf expression epidermis also significantly correlated blood vessels area lymphatic microcirculation found statistically significant positive correlation lymphatic vessels area cellular infiltration dermis weak correlation epidermal hyperplasia hypothesize angiogenesis psoriasis greater extent responding epidermal hyperplasia lesser way inflammatory infiltration dermis however lymphangiogenesis significantly related dermal inflammatory infiltration
effects quintic nonlinearity ultrashort optical pulse propagation non kerr medium twin core nonlinear optical fiber waveguide described coupled cubic quintic nonlinear schrodinger equations variable coefficients equations lax pair infinitely many conservation laws constructed certain variable coefficient constraints bilinear forms bilinear backlund transformations bright dark one two soliton solutions derived via hirota method symbolic computation soliton solutions merely related delayed nonlinear response effect graphical analyses soliton propagation interaction suggest affect bright dark soliton velocities effect amplitudes different choices propagation linear periodic parabolic type bight dark one solitons seen different types interaction bright two solitons displayed interactions bidirectional bright two ones unidirectional bright two ones moving bright one stationary one interactions linear parabolic type dark two solitons asymptotically analyzed graphically illustrated well interactions elastic
buildings consume significant proportion world resources mostly form materials usage addition ongoing efforts focusing reducing operational energy consumption buildings embodied emissions buildings expected increase proportion future increasing focus placed embodied emissions buildings organizations construction industry face requirements report information regarding embodied emissions buildings however order obtain embodied emission buildings tremendous efforts placed process data intensive order overcome challenge streamlined technique proposed minimize efforts required practitioner obtain embodied carbon footprint proposed technique comprises probabilistic model emission factor estimators used estimate required embodied emissions based four projects presented case study proposed technique practitioner would required manually match appropriate emission factors activity data data points contrast current traditional technique requires manual matching data points resultant deviation computed embodied carbon footprint proposed technique current technique elsevier ltd rights reserved
investigation paper coupled higher order nonlinear schrodinger equations variable coefficients represent propagation femtosecond soliton pulses comprising two fields left right polarization inhomogeneous optical fiber media infinitely many conservation laws obtained based lax pair via hirota method symbolic computation bilinear forms bilinear backlund transformations one two soliton like solutions also derived different coefficients bell shaped periodic changing quadratic varying exponential decreasing exponential increasing soliton like profiles seen describe propagation interactions femtosecond soliton pulses head overtaking elastic interactions shown decided directions velocities also get bound states periodic attraction repulsion two solitons elsevier rights reserved
quantum key distribution qkd systems exploit laws quantum mechanics generate secure keying material cryptographic purposes date several commercially viable decoy state enabled qkd systems successfully demonstrated show promise high security applications banking government military environments work detailed performance analysis decoy state enabled qkd systems conducted model simulation several common decoy state configurations results study uniquely demonstrate decoy state protocol ensure photon number splitting pns attacks detected high confidence maximizing system quantum throughput additional cost additionally implementation security guidance provided qkd system developers users
aim aim study clarify rates remission progression microalbuminuria patients type diabetes tdm factors associated remission progression diabetic nephropathy patients methods tdm patients urinary albumin excretion uae rate gcr attending medical clinic tsugaru region japan enrolled prospective observational study months investigated rate remission uae gcr overt proteinuria months study registration results number patients whose uae levels gcr progression months registration multiple logistic regression analysis sole factor contributed remission months registration uae levels registration factors contributed progression months registration levels uae systolic blood pressure registration conclusion results suggest patients less severe microalbuminuria among microalbuminuric patients might commonly experience remission earlier intervention important promoting microalbuminuria remission
conducted evaluated coaching intervention aimed encouraging menopausal women engagement goal oriented actions self efficacy enhancement menopausal symptom alleviation quality life improvement study randomized controlled trial comprising women aged receiving hormone therapy intervention group received leaflets three monthly coaching sessions instruments included simplified menopausal index medical outcome study item short form health survey goal achievement scale participants measured preintervention immediately postintervention three months postintervention month coaching intervention enhance menopausal women health increased self efficacy effect maintained months postintervention
neuroimaging techniques greatly enhanced understanding neurodiversity human brain variation across individuals health disease ultimate goal using brain imaging biomarkers perform individualized predictions proposed generalized framework predict explicit values targeted measures taking advantage joint information multiple modalities framework also enables whole brain voxel wise searching combining multivariate techniques relieff clustering correlation based feature selection multiple regression models flexible achieve better prediction performance alternative atlas based methods healthy controls schizophrenia patients three kinds features derived resting state fmri falff smri gray matter dti fractional anisotropy extracted fed regression model achieving high prediction cognitive scores mccb composite mccb social cognition symptomatic scores positive negative syndrome scale panss positive panss negative moreover brain areas likely responsible cognitive deficits schizophrenia including middle temporal gyrus dorsolateral prefrontal cortex striatum cuneus cerebellum located different weights well regions predicting panss symptoms including thalamus striatum inferior parietal lobule pinpointing potential neuromarkers finally compared single modality multimodal combination achieves higher prediction accuracy enables individualized prediction multiple clinical measures work done current results highlight potential utility multimodal brain imaging biomarkers eventually inform clinical decision making elsevier inc rights reserved
purpose toddler years temper tantrums impulsive behaviors norm behaviors frustrate even experienced mothers design methods prospective double blind randomized controlled trial using pre test post test experimental design used examine effectiveness office based educational program improve maternal confidence social emotional development toddlers toddler care questionnaire tcq administered mothers pre post intervention test treatment intervention videotaped dvd parenting skills intervention social emotional development toddlers onmaternal confidence caring toddlers results sixty mothers toddlers entered study mothertoddler dyads randomized treatment group control group twenty six mother toddler dyads treatment mother toddler dyads control group completed study pairwise comparisons adjusted means showed significant improvements toddler groups brigance toddler screen statistically significant difference gains groups mixed model results tcq showed overall significant improvement preto post test non significant interaction group time indicting significant difference gains seen treatment groups conclusions brief educational programs dvd efficient way offer information mothers office waiting area practice implications pediatric nurses encounter mothers struggle caring toddlers may find brief office based interventions valuable tool educating parents elsevier inc rights reserved
intensification agriculture brazilian cerrado last four decades resulted unintended consequences increased groundwater surface water pollution due excessive fertilization address problems within coffee coffea arabica orchard process based animo model used simulate nitrate nitrogen leaching plant nitrogen uptake several rates effects splitting applications three times per year every day also evaluated typic hapludox within cerrado statistical analysis animo outputs showed simulated soil solution concentrations agreement experimental measurements collected entire year simulated annual uptake also agreement average measured uptake coffee plants evaluation simulation scenarios showed efficient recovery associated rates split least seven applications per year recovery rates efficient without split application iii environmentally friendly management strategy application using least seven splits reducing rate increased plant recovery efficiency reduced leaching predicted leaching plant uptake results confirm better management strategies developed coffee plantations crops grown cerrado elsevier rights reserved
mycobacteriosis infrequently reported free ranging sea turtles nontuberculous mycobacterium haemophilum identified causative agent disseminated mycobacteriosis juvenile leatherback turtle dermochelys coriacea found stranded atlantic coast florida disseminated granulomatous inflammation identified histologically notably affecting nervous system identification mycobacterial infection based cytologic molecular histologic microbiologic methods among stranded sea turtles received diagnostic evaluation atlantic gulf mexico coasts united states diagnosis mycobacteriosis overrepresented stranded oceanic phase juveniles compared larger size classes suggests potential differences susceptibility exposure among different life phases region describe haemophilum sea turtle contributes knowledge diseases small juvenile sea turtles especially cryptic life phase leatherback turtle
background recombinant human inhibitor rhcinh demand treatment hereditary angioedema purified milk transgenic rabbits contains low amounts host related impurities could trigger hypersensitivity reactions patients rabbit allergy cow milk allergy cma objective study assessment allergenicity safety rhcinh patients cma methods patients cma underwent skin prick test spt intracutaneous test ict results negative subcutaneous challenge rhcinh negative predictive value skin test protocol calculated defined ratio patients without systemic symptoms hypersensitivity following challenge number patients tested negative spt ict adverse events exposure rhcinh recorded results twenty six patients cma enrolled twenty four negative spt ict results rhcinh whereas negative spt result positive ict result rhcinh highest concentration twenty two patients negative spt ict results underwent challenge none developed allergic symptoms local treatment emergent adverse events occurred patients challenge considered drug related mild conclusions none patients negative spt ict results rhcinh allergic symptoms rhcinh challenge negative predictive value combination spt ict outcome challenge administration rhcinh well tolerated
purpose laparoscopic appendectomy routinely performed general regional anesthesia study assessed feasibility efficacy side effects combined spinal epidural anesthesia csea methods thirty three american society anesthesiologist asa physical status classification grade patients underwent csea csea performed using needle needle technique interspace preoperative postoperative adverse events related csea patient satisfaction postoperative pain levels recorded results csea performed successfully patients peroperatively right shoulder pain observed patients abdominal discomfort anxiety hypotension nausea vomiting first hours headache urinary retention right shoulder pain postoperative nausea vomiting ponv occurred patients respectively first hours postoperation patients operation site pain required analgesic treatment thirty one patients evaluated satisfaction procedure good moderate conclusion csea efficient suitable anesthesia technique asa physical status classification grade healthy patients csea associated good postoperative pain control absence ponv intubation associated complications
literature review explores major theories explanatory mechanisms occurrence false memories deese roediger mcdermott paradigm drm study presents data empirical studies support theories discusses implications understanding false memories historically first theories explaining false memories focused concept association order explain intrusions memory tasks later concept activation received greater importance explaining false memories drm paradigm however activation insufficient explain results described several authors therefore two current major theories explain false memories drm paradigm activation monitoring theory fuzzy trace theory consider existence monitoring control mechanisms together activation mechanisms monitoring mechanisms operate opposite direction activation mechanisms explain decrease disappearance false memories certain circumstances although different activation monitoring fuzzy trace theories reconcilable perspectives may necessary comprehensive understanding false memories drm paradigm thus propose adoption theoretical approach integrates contributionsfrom theories
studied paper bright dark vector soliton solutions generalized coupled hirota system describes propagation high intensity ultrashort pulses optical glass fiber beyond existing bilinear forms using auxiliary function obtain improved bilinear forms bright dark soliton solutions two integrable constraints hirota method symbolic computation help analytic graphic analysis study soliton properties including amplitudes velocities phase shifts show interactions bright dark two solitons elastic bright dark one soliton parametric conditions dark component black gray obtained bright dark two solitons find bright component affected dark component background parameters interaction dark component affected bright component background parameters velocities bright dark two solitons inversely proportional higher order effect parameter amplitudes phase shifts independent besides bound state bright dark two solitons also presented elsevier rights reserved
online question answer forums emerging excellent learning platforms learners varied interests paper present results clustering stack overflow users four clusters namely naive users surpassing users experts outshiners clustering based various metrics available forum use means expectation maximization clustering algorithms compare results results validated using internal external relative validation techniques objective clustering able trace predict activity user forum according results majority users users consideration fall experts category indicates users stack overflow high quality thereby making forum excellent platform users learn computer programming
background objective injuries leading cause death significant disability utilization acute medical care study describes patterns acute care services use related injury associated costs among children adolescents state medicaid population methods retrospective cross sectional descriptive research design used analyze west virginia medicaid fee service computerized claims acute care medical services primary diagnosis injury complication due injury recipients years age medical services utilization rates calculated stratified demographic categories well type injury costs associated claims perspective medicaid results children hospitalized visited emergency department injury complication due injury rate per children white male years age highest rate acute care use demographic groups medicaid paid approximately million injury related acute care visits acute care mostly delivered emergency department although hospitalizations contributed one third total costs average length hospital stay type injury complication due injury days overall diagnosis traumatic complication frequently occurring followed open wounds contusions sprains strains fractures codes readily recorded conclusion use injury related acute medical care varied demographic variables diagnosis findings study used baseline surveillance guide development interventions contain preventable injuries associated treatment costs
might seem reasonable assumption actively using faces express display nonexpressive neutral faces around able read emotions herein using variety expression related ratings examined whether age related changes face accurately reveal one innermost affective dispositions study found expressive ratings neutral facial displays predicted self reported positive negative dispositional affect elderly women positive affect findings meaningfully replicate extend earlier work examining age related emotion cues face elderly women malatesta discuss findings light evidence women expected smile men quality smiles predicts life satisfaction although ratings old male faces significantly predict self reported affective dispositions trend similar found old female faces plausible explanation gender difference process attenuating emotional expressions lifetimes old men reveal less evidence total emotional experiences faces old women
geosynthetics planar polymeric products used connection soil rock soil like materials fulfill various functions geoenvironmental engineering geosynthetics ever growing importance construction industry sealing waste storage facilities safely prevent emission wastewater landfill gas contaminated dust well diffusion pollutants environment coastal protection storms floods reconstruction natural disaster important fields application give overview various geosynthetic products two examples material problems related geosynthetics discussed detail effect creep long term performance geocomposite drains numerical simulation interaction soil geogrids issues importance use products landfill capping systems various functions geosynthetics may fulfill protection coastal lines illustrated case studies geosynthetic market evaluated economical environmental benefits well environmental side effects related use geosynthetics discussed
paper presents results computational fluid dynamics cfd model study hydraulics groundwater flow porous pipe underdrains study conducted using three dimensional cfd model built ansys fluent model validated replicating previous experimental results saturated subsurface flow water surface level aggregate perforated pipe shrouded loose laid aggregate cfd model consistently overpredicted flow rate given head aggregate depth average considering effect pipe perforation blockage due aggregate average overprediction decreased discharge coefficient perforated pipe computed using cfd model compared experiments also found discharge quite small upstream end pipe bulk water entering pipe vicinity outlet finally computational results showed saturated flow conditions flow predominantly vertical direction within aggregate whereas mainly horizontal water surface level top aggregate level unsaturated condition losses associated two flow scenarios explored results obtained practical applications design analysis porous pipe underdrains
background adults coeliac disease often report persistent fatigue even appears well controlled unknown reasons aims evaluate common indications testosterone panel testing prevalence low testosterone methods case series determined common indications checking next conducted case control study compare healthy controls compared mean total free based serologic histologic disease activity finally assessed tissue transglutaminase ttg ttg subjects obtained national health nutrition examination survey nhanes results coeliac males tested common indications included osteoporosis fatigue low observed men osteoporosis fatigue case control study difference mean ttg ttg marsh marsh groups nhanes data showed difference mean ttg ttg subjects conclusions low occurs patients similar rate general population common presentations low may mimic non responsive symptoms editrice gastroenterologica italiana published elsevier ltd rights reserved
motion capture useful technique creating animations instead manual labor expensive camera based devices restrict practical application emerging inexpensive small size depth sensing devices provides opportunities reconstitute motion capture system introduced network depth sensors production real time dcg animation different existing system new system works well data communication anime rendering discuss server communicate group sensors operate group sensors rendering animation results verification experiments provided well
strength materials suffering subcritical crack growth sccg affected loading conditions environment crack growth also occur measurement material fracture toughness yielding lower measured apparent values work measurements two different brittle materials compared different environments water ambient air argon using three testing methods single edge notch beam chevron notch beam iii ball three balls strong effect environment found measured values using three methods low values measured water similar mpa depending material whereas higher toughness values obtained argon similar mpa explained model accounting sccg fracture toughness experiment recommendations assessment fracture toughness brittle materials given elsevier ltd rights reserved
animals self grooming important component overall hygiene reduces risk disease parasites european honey bee apis mellifera exhibits hygienic behavior refers ability members colony remove diseased dead brood hive individual grooming behavior however bee grooms remove parasites behaviors critical mitigation disease hygienic behavior overwhelmingly studied unlike grooming behavior simple bioassay measure phenotype develop novel bioassay expedite data collection grooming behavior testing different honey bee genotypes stocks individual worker bees different commercial stocks coated baking flour placed observation arena digitally recorded automatically measure grooming rates videos analyzed matlab exponential function fit pixel data calculate individual grooming rates bees different commercial stocks significantly different grooming rates automation grooming measurements may facilitate future research stock selection important mechanism social immunity elsevier rights reserved
active cancellation stealth significant developing direction modern stealth technology field paper according characteristics linear frequency modulated lfm signal nonlinear frequency modulated nlfm signal cancellation signal designed important parameter called cancellaty used measure effect cancellation proposed basic theory active cancellation stealth introduced based radar target fluctuation models formulas radar detection probability given combining definition cancellaty radar detection probability effective scope cancellaty ensured simulation results show effectiveness practicability active cancellation
study three different types electrical circuit equations using fractional calculus various definitions fractional derivative therein using plotting tools compare different types solutions equation among well classical solution
nervous control heart atp cotransmitter sympathetic parasympathetic sensory motor nerves well intracardiac neurons centers brain control heart activities vagal cardiovascular reflexes involve purines adenine nucleotides nucleosides act purinoceptors cardiomyocytes nodes cardiac fibroblasts coronary blood vessels vascular tone controlled dual mechanism atp released perivascular sympathetic nerves causes vasoconstriction largely via receptors endothelial cells release atp response changes blood flow via shear stress hypoxia act receptors endothelial cells produce nitric oxide endothelium derived hyperpolarizing factor prostaglandins cause vasodilation atp also released sensory motor nerves antidromic reflex activity produce relaxation blood vessels purinergic signaling involved physiology erythrocytes platelets leukocytes atp released erythrocytes platelets purinoceptors ectonucleotidases expressed cells receptors expressed platelets mediate platelet aggregation shape change long term trophic actions purine pyrimidine nucleosides nucleotides promote migration proliferation vascular smooth muscle endothelial cells via receptors angiogenesis vessel remodeling restenosis angioplasty atherosclerosis involvement purinergic signaling cardiovascular pathophysiology therapeutic potential discussed including heart failure infarction arrhythmias syncope cardiomyopathy angina heart transplantation coronary bypass grafts coronary artery disease diabetic cardiomyopathy hypertension ischemia thrombosis diabetes mellitus migraine
background one important transitions continuum care children discharge home optimal discharge communication healthcare providers caregivers parents guardians present emergency department children well understood lack policies considerable variation practice regarding discharge communication pediatric eds pose quality safety risk children parents methods aim mixed methods study better understand process structure discharge communication pediatric context contribute design development discharge communication interventions use surveys administrative data real time video observation characterize discharge communication six common illness presentations pediatric asthma bronchiolitis abdominal pain fever diarrhea vomiting minor head injury participants recruited one two urban pediatric eds canada video recordings analyzed using observer use logistic regression identify potential demographic visit characteristic cofounders multivariate logistic regression examine association verbal non verbal behaviours parent recall comprehension discussion video recording discharge communication provide opportunity capture important data temporality sequence non verbal behaviours might influence communication process given importance better characterizing discharge communication identify potential barriers enablers anticipate findings study contribute development effective discharge communication policies interventions
three main magnet systems wendelstein comprising total coils arranged independent circuits fed steady state power supplies superconducting coil system creates main magnetic field consists coils grouped seven electrical circuits ten coils inductance one henry circuit fed one power supply maximum current maximum voltage power supplies tested far using copper coils one omega one integral commissioning completed coil circuits running since end april second coil system called trim coil system intended enhanced experimental flexibility error field corrections consists five independently powered copper coils placed outer side cryostat operated currents power supply connected three phase grid consists input transformer dual secondaries connected two three phase systems followed two diode six pulse diode bridges configured pulse rectifier power conversion accomplished paralleled bridges using igbt full scale ratings power supply tests full current performed power supplies using dummy loads successful tests performed actual trim coils rated current november third magnet system divertor control coil system ten normal conducting copper coils situated inside plasma vessel behind divertor targets arranged ten independent circuits pulse system power supplies generated manner power supplies superconducting coils followed rectifier diodes inverter stage made bridge converter mosfet transistors parallel per branch current rating power supply value modulated current frequencies final commissioning control coil system started february
trauma especially early life trauma risk factor development posttraumatic stress disorder psychosis goal present study determine specific associations exposure childhood abuse ptsd symptoms current psychotic disorder subjects recruited public urban hospital african american psychotic disorders measured using mini international neuropsychiatric interview ptsd measured using clinician administered ptsd scale child abuse measured childhood trauma questionnaire lifetime trauma exposure measured traumatic events inventory logistic regression analyses showed child abuse current ptsd statistically significant predictors psychotic disorder beyond effects lifetime trauma load ptsd symptom clusters examined avoidance numbing symptoms showed unique association psychotic disorder independent demographic variables trauma exposure using bootstrapping techniques found full indirect effect ptsd association child abuse suggesting particularly important role ptsd symptoms relation psychotic disorder presence early life trauma cross sectional study continued research needed determine causality models identifying occurring psychosis ptsd particularly populations high levels trauma exposure critical likely aid successful treatment interventions authors published elsevier ltd
nowadays wide range stakeholders seek explicit performance risk information construction projects stakeholders include end users authorities insurance companies financial institutions among others look proof engineering risks properly managed specified performance based requirements fulfilled throughout stages project technical requirements related building structural safety structural serviceability structural durability fire safety energy efficiency others demonstration conveyed statements technical conformity technical risk reports engineering performance certificates statements conformity particularly valuable make informed decisions associated contractual legal warranties building nonconformities paper describes conceptual background methodologies undertaken design develop management framework enables recognition conformity assessment results building projects also presents outreach management framework throughout planning programming design construction use phases building projects paper also summarizes wide range practical implications benefits management framework authorities official bodies owners representatives banks insurance companies conformity assessment bodies designers builders suppliers end users
multi attribute value theory mavt used investigate stakeholders preferences beliefs ameliorating deteriora ting ecosystem vosvozis river ismarida lake northeastern greece various monetary environmental criteria evaluated scores weights different stakeholder groups key individuals farmers fishermen entrepreneurs residents ecologists elicit preferences concerning alternative protection scenarios ultimate objective propose policy recommendations sustainable water resources management case study area analysis revealed overwhelming agreement among stakeholders regarding dire need immediate actions order preserve enhance vosvozis ecosystem two stage evaluation process mavt analysis led high consensus among stakeholders alternative favors water recycling wastewater treatment plant combined small dams rainwater harvesting elsevier rights reserved
million children united states suffer chronic health conditions including cancer sickle cell disease diabetes major advances early identification treatment conditions survival rates children continue rise majority lives adulthood however increases survival come costs related long term effects disease processes treatments foremost among consequences impairment brain development neurocognitive function may affect substantial portion children chronic health conditions follow many adulthood impaired cognitive function may contribute impairment educational occupational attainment mental health quality life children chronic conditions despite significance scope problem advances identification understanding neurocognitive problems delivery effective clinical care hindered part research siloed conducted chronic condition isolation review examines first time neurocognitive problems selected set chronic pediatric health conditions leukemia brain tumors sickle cell disease congenital heart disease type diabetes traumatic brain injury define magnitude problem identify directions future research clinical care psychologists many areas specialization including pediatric psychology educational school psychology neuropsychology behavioral medicine adult primary care uniquely positioned contribute every phase work including research identification intervention
multiple input multiple output linear quadratic servo controller proposed synchronous generator operating nuclear power plant keeps active power desired level performs reactive power reference tracking using reacti
percutaneous left atrial appendage closure backgroundthere limited data watchman boston scientific corporation natick usa left atrial appendage laa closure patients nonvalvular atrial fibrillation contraindications anticoagulation purpose study evaluate safety efficacy watchman early canadian experience methodswe report pooled consecutive series patients underwent watchman implantation four major canadian centers indications laa closure chads cha vasc contraindication intolerance failure anticoagulation follow imaging typically performed months postprocedure resultsone hundred six patients underwent laa closure watchman may october mean age mean chads score cha vasc score hasbled score permanent present paroxysmal indications laa closure prior bleeding major bleeding minor bleeding deemed high risk bleeding recurrent strokes warfarin procedural success one device embolization snared percutaneously one implant failure due inadequate laa depth one cardiac perforation requiring surgical repair watchman implantation composite major safety event rate death device embolization mean hospital stay days antithrombotic therapy postimplant included dual antiplatelet therapy mean follow days two transient ischemic attacks estimated reduction thromboembolic events relative chads predicted risk conclusionin early canadian experience watchman laa closure patients contraindicated anticoagulation appeared safe effective
impaired insulin stimulated glucose uptake skeletal muscle serves critical role development insulin resistance whereas precise mechanism process remains unknown recently evolutionarily conserved stress inducible protein sestrin sesn proposed play protective role obesity induced diabetes activation sesn may activate amp activated protein kinase ampk accompanied suppression mammalian target rapamycin mtor may ultimately lead autophagy induction view potential protective effects autophagy physiological pathological regulatory processes via regulation energy homeostasis metabolism investigated effects sesn components insulin signaling pathway insulin stimulated glucose uptake palmitate induced insulin resistant myotubes showed sesn effectively restored impaired insulin signaling moreover autophagic activity decreased response palmitate whereas sesn significantly reversed palmitate suppressed autophagic signaling context findings revealed sesn induced autophagy contributed restore impaired insulin signaling activation ampk signal even presence palmitate sesn regulation maintained insulin sensitivity glucose metabolism via ampk dependent autophagic activation
objective although hispanic adolescents usa often focus sexual health interventions response survey measures rarely assessed within evaluation studies study documents test retest reliability wide range self reported sexual health values attitudes knowledge behaviours among hispanic adolescents low income urban communities method intraclass correlation coefficients calculated sexual health scales knowledge values condom use parent communication protection self efficacy condom use intentions week sample cohen kappa intraclass correlation coefficients calculated behaviours romantic sexual behaviours sexual health services history two separate week samples selected behaviours also examined retractions week samples year sample results among sexual health scales test retest reliability ranged condom use intentions parent communication among behaviours reliability ranged use sexual health services use birth control first sex retractions ranged ever steady partner sexual health services testing conclusion test retest reliability differed greatly across self reported sexual health values attitudes knowledge behaviours three samples hispanic adolescents overall however items scales showed good excellent reliability coefficient greater suggesting hispanic adolescents moderately highly stable reporters response sexual health measures
background although robust evidence linking childhood adversities cas increased risk psychotic experiences pes little known whether associations vary across life course whether mental disorders emerge prior pes explain associations method assessed cas pes dsm mental disorders adults world mental health surveys discrete time survival analysis used investigate associations cas pes influence mental disorders associations using multivariate logistic models results exposure cas common experienced cas increased odds later pes odds ratio confidence interval cas reflecting maladaptive family functioning mff including abuse neglect parent maladjustment exhibited strongest associations onset life course stages sexual abuse exhibited strong association onset childhood whereas types associated onset adolescence associations cas pes disappeared adolescence adjustment prior onset mental disorders population attributable risk proportion parp pes associated cas mff conclusions exposure cas associated onset throughout life course although sexual abuse strongly associated childhood onset pes presence mental disorders prior onset pes fully explain associations large parps suggest preventing cas could lead meaningful reduction pes population
recent advances flow based microfluidic biochips enabled emergence lab chip devices bimolecular recognition point care disease diagnostics however adoption flow based biochips hampered today lack computer aided design tools manual design procedures delay product development also inhibit exploitation design complexity possible current fabrication techniques paper present first practical problem formulation automated control layer design flow based microfluidic large scale integration mvlsi biochips propose systematic approach solving problem goal find efficient routing solution control layer design minimum number control pins pressure propagation delay intrinsic physical phenomenon mvlsi biochips minimized order reduce response time valves decrease pattern set time synchronize valve actuation two fabricated flow based devices six synthetic benchmarks used evaluate proposed optimization method compared manual control layer design baseline approach proposed approach leads fewer control pins better timing behavior shorter channel length control layer
background diabetes highly prevalent among medicare beneficiaries resulting costly health care utilization strategies improve health outcomes disease self management could help reduce increasing burden diabetes objectives short term benefits diabetes self management training dsmt established however longer term impacts among medicare beneficiaries unknown research design claims based observational study year follow beginning months diabetes diagnosis subjects twenty percent random sample medicare beneficiaries newly diagnosed diabetes used dsmt matched nonuser comparison group measures compared health service utilization costs dsmt users nonusers health service utilization included utilization hospital emergency department hospitalizations due diabetes related ambulatory care sensitive conditions well number hospitalizations visits within follow year costs included medicare parts expenditures results multivariate regression results found dsmt users reduced odds hospitalization lower numbers hospitalizations visits approximately fewer per approximately lower medicare expenditures compared nonusers odds hospitalization due diabetes related ambulatory care sensitive conditions visit lower dsmt users compared nonusers reductions statistically significant conclusions findings demonstrate benefits dsmt use including lower health service utilization costs low cost dsmt relative reduction medicare expenditures highlights opportunity reduce burden diabetes individuals health care system
applications artificial roughness underside absorber plate solar air heater duct widely used improve heat transfer moderate increase friction factor design roughness shape arrangement important optimize roughened surfaces roughness parameters ribs arrangement responsible alter flow structure heat transfer mechanisms mainly governed flow structure critical reviews various artificial roughness elements available literature conducted effects roughness patterns discussed nusselt number friction factor correlations various roughness elements summarized comparison study thermohydraulic performance different roughness elements also reported understand results applications artificial roughness
paper proposes multiinput switched capacitor integrators required realization leapfrog filters exhibiting zero sensitivity matching points signal flow graph based simulation ladder filter built proposed integrators shows filter exhibits zero sensitivity integrators driven two phase dock certain conditions insensitive parasitic capacitance furthermore total filter capacitance generally kept small computer simulation lowpass bandpass filters constructed proposed integrators illustrates comparatively low sensitivity
calibration drucker prager cap dpc model parameters provides means deeper understanding impact granule composition compaction properties dry granules independent solid fraction study monodisperse granules mixtures microcrystalline cellulose mannitol mannitol prepared small cylindrical compacts well defined size shape solid fraction used model dry granules dpc parameters namely cohesion internal friction angle cap eccentricity hydrostatic yield strength materials determined diametrical uniaxial compression die compaction tests elastic properties young modulus poisson ratio also determined die compaction test higher level mannitol granules required lower compression pressure obtain low solid fraction tablet higher compression pressure obtain high solid fraction tablets properties cohesion diametrical tensile strength maximum mannitol level increases binary granules clearly follow simple linear mixing rule industrially relevant tablet solid fraction granules mannitol exhibited highest cohesion produced strongest tablet properties either approximately follow linear mixing rule hydrostatic yield strength young modulus poisson ratio limited interactions constituents present sensitive composition internal angle friction general compaction behavior granules multi component system may precisely estimated properties individual components simply using linear mixing rule elsevier rights reserved
purpose multiple preterm birth associated maternal psychological distress less positive mother infant interactions singleton preterm birth study purpose compare psychological distress relationship infants mothers multiples mothers singletons design exploratory secondary analysis longitudinal data sample mothers preterm infants main outcome variables maternal psychological distress depressive symptoms anxiety posttraumatic stress pts parenting stress mother infant relationship worry child vulnerability maternal positive involvement developmental stimulation child developmental maturity irritability social behaviors home environment results mothers multiples greater pts symptoms baseline anxiety discharge depressive symptoms six months mothers singletons mothers multiples also positive home environments six months multiple birth risk factor psychological distress less positive mother infant interactions
purposechronic obstructive pulmonary disease copd irreversible lung disease characterized small airway obstruction alveolar airspace destruction hyperpolarized diffusion mri lung promising biomarker assessing airspace enlargement yet validated direct comparison lung histology compared diffusion measurements hyperpolarized explanted lungs regionally matched morphological measures airspace size methodsexplanted lungs five copd patients two idiopathic pulmonary fibrosis ipf patients imaged using mri hyperpolarized using two value gradient echo diffusion sequence histological samples taken lungs quantitative histology mean linear intercept compared spatially matched measures apparent diffusion coefficient adc mri resultsthe mean adc copd lung samples ipf lungs groups mean copd samples ipf groups pearson correlation adc measurements conclusionsdiffusion mri quantifies regional airspace enlargement copd adc showed much less overlap groups quantitative histology consistent past experience diffusion mri copd magn reson med wiley periodicals inc
objective aim study evaluate chondroprotective effect chemically decellularized meniscal allografts transplanted knee joints adult merino sheep methods lateral sheep meniscal allografts chemically processed multistep method yield acellular sterile grafts grafts transplanted knee joints sheep treated lateral meniscectomy joints treated meniscectomy untreated joints served controls joints analyzed morphologically weeks surgery macroscopical histological oarsi osteoarthritis research society international score additionally meniscal grafts biomechanically tested cyclic indentation results lateral meniscectomy associated significant degenerative changes articular cartilage lateral joint compartment transplanted lateral meniscal allografts retained integrity observation period without inducing significant synovitis foreign body reactions cellular repopulation grafts present surface periphery lateral meniscus still completely lacking center grafts week transplantation processed meniscal allografts could prevent degenerative changes articular cartilage lateral joint compartment compared healthy menisci processed grafts characterized significantly reduced dynamic modulus improve observation period weeks vivo conclusion chemically decellularized meniscal allografts proved biocompatibility durability without inducing immunogenic reactions however insufficient recellularization inferior stiffness grafts hampered chondroprotective effects articular cartilage
objective paucity information sub saharan africa impact postmenopausal vaginal atrophy women male partners south africa investigated methods four hundred individuals south africa postmenopausal women experienced symptoms vaginal atrophy male partners completed structured questionnaire results sixty eight percent women avoided intimacy vaginal discomfort men described observing behavior partners consequently women men reported decreased sexual activity women men believed vaginal discomfort caused big problem significantly higher proportions women men described put sex feeling emotionally distant partners twenty one percent women used local estrogen therapy reporting benefits including feeling happy body working increased confidence sexual partners conclusion many postmenopausal women partners symptoms vaginal atrophy adversely affected sex relationships physically emotionally substantial improvements reported women received local estrogen therapy supporting greater efforts improve awareness accessibility treatment south africa
persons psychosis often report high levels posttraumatic stress disorder ptsd symptoms render vulnerable relapse symptom exacerbation reduced well however less known adequately accommodate needs persons recovering first episode psychosis presenting ptsd existing evidence based interventions ptsd seem less equipped deal serious mental disorder comorbid conditions study aimed assess efficacy acceptability safety acceptance commitment therapy act persons suffering ptsd comorbid trauma psychosis three consecutively referred participants meeting icd criteria ptsd first episode noneffective psychotic disorder treated outpatient service within case series analysis manual guided act intervention sessions showed clinically relevant improvement self report measures ptsd symptoms emotional distress initial findings promising appear justify controlled evaluation brief intervention
improve condition air eliminate exhaust gas pollution article proposes compressed air power system instead internal combustion engine automobile equipped compressed air engine transforms energy compressed air mechanical motion energy prototype built compressed air engine tested experimental platform output torque energy efficiency obtained experimental results supply pressure set mpa speed min output torque output power energy efficiency respectively improve efficiency system fuzzy logic speed control strategy proposed simulated experimental study verified theoretical evaluation system reasonable research referred design control air powered vehicles
often deployed remote hostile environments wireless sensor networks vulnerable various types security attacks possible solution reduce security risks use directional antennas instead omnidirectional ones conjunction due increased complexity higher costs larger sizes directional antennas traditionally used wireless sensor networks recent technology trends may support method paper surveys existing state art approaches field offering broad perspective future use directional antennas mitigating security risks together new challenges open research issues
rainwater harvesting provide alternative water source may demand little treatment depending end use starches used water treatment coagulant flocculant filtration aid might applied primary coagulant show direct filtration hydraulic rapid mixing using cationic corn starch primary coagulant considerably improves roof harvested rainwater quality achieving removal efficiencies apparent colour turbidity log unit total coliform log unit escherichia coli meeting guidelines turbidity even potable purposes cationic corn starch proved suitable primary coagulant filtration performed single layer sand filter coefficient uniformity effective particle size hydraulic loading rate day however disinfection unit required meet absence faecal coliform
growing clinical pre clinical evidence points critical role cannabidiol cbd largest phytochemical component cannabis potential pharmacotherapy various neuropsychiatric disorders contrast delta tetrahydrocannabinol thc associated acute neurodevelopmental pro psychotic side effects cbd possesses known psychoactive dependence producing properties however evidence demonstrated cbd strongly modulates mesolimbic dopamine system may possess promising anti psychotic properties despite psychotropic differences cbd thc little known regarding molecular neuronal effects mesolimbic system differential effects may relate potential pro anti psychotic properties review summarizes clinical pre clinical evidence demonstrating cbd modulatory effects activity states within mesolimbic pathway functional interactions serotonin hta receptor system downstream molecular signaling effects together clinical evidence showing cbd may normalize affective cognitive deficits associated schizophrenia cbd may represent promising treatment schizophrenia acting novel molecular neuronal mesolimbic substrates elsevier ltd rights reserved
hereditary angioedema hae rare bradykinin mediated disease characterized recurrent attacks subcutaneous submucosal edema life threatening hae affects ethnic groups equally differentiate age sex race however availability therapies varies amongst countries resulting lack uniformity care disparity medication availability since hae rare disease frequently overlooked diagnosis missed even diagnosis treatment management often less optimal reasons essential practice parameters guidelines chapter focus recent guidelines guidelines deal recognition diagnosis medical care patient management assessment essential provide optimal care people rare orphan disease intent guidelines thus chapter reduce morbidity mortality restore normal quality life patient hae review guidelines various regions world well international group recommendations addition specific patient populations pregnant elderly juvenile require modified treatment regimens reason included data well intent chapter aid practitioner holistic care patient hae order ultimately provide best standard care possible
objective children often present pediatric emergency department reported penicillin allergy true incidence pediatric penicillin allergy low patients may inappropriately denied first line antibiotics hypothesized reported penicillin allergies pediatric low risk true allergy methods parents children presenting pediatric parent reported penicillin allergy completed allergy questionnaire questionnaire included age allergy diagnosis symptoms allergy time allergic reaction first dose allergy symptoms dichotomized high low risk consultation pediatric allergist questionnaire implementation results total parents approached completed survey median interquartile range age children diagnosis year months years diagnosed third birthday overall confidence interval children exclusively low risk symptoms commonly reported symptoms rash itching children one high risk symptom facial swelling common overall children diagnosed first exposure penicillin symptom onset within hours medication administration occurred children conclusions seventy six percent patients parent reported penicillin allergy symptoms unlikely consistent true allergy determination true penicillin allergy patients low risk symptoms may permit increased use first line penicillin antibiotics
problem cleaning structural monitoring data thermal effects studied since pioneering developments area first attempts approached problem statistical way terms time history correlations availability powerful numerical tools able solve thermo mechanical stress strain analysis suggests pursuing dynamic modeling approach however defining boundary conditions assigning initial conditions problematic aspects analysis discussed paper proposed procedure exemplified reference existing railway bridge
investigation conducted determine variations dimensions multi component geosynthetic clay liners gcls two gcls tested sample relatively smooth geofilm sample textured geofilm discrete effects cyclic wetting drying initial moisture content overburden pressure temperature underlying subgrade soil determined coupled effects underlying subgrade soil climatic conditions evaluated outdoor simulated field environment cyclic wetting drying resulted net shrinkage gcls shrinkage strains machine cross machine directions respectively specimens high initial moisture contents underwent shrinkage early wet dry cycles low initial moisture however initial moisture significant effect ultimate shrinkage machine direction strains exceeded values would cause panel separation field within first two cycles whereas least seven cycles required panel separation strains cross machine direction temperature effects alone result significant shrinkage specimens placed soil subgrades without wetting drying underwent moisture changes however experienced less shrinkage subjected wet dry cycling gcls underwent significant diurnal temperature variations outdoors however shrinkage specimens similar observed subgrade tests specimens higher initial moisture contents underwent dimensional change specimens lower moistures type geosynthetic contact underlying soil influenced gcl soil systems woven geotextile sides soil subgrades resulted high moisture transfer shrinkage
construction procurement negotiation one key subjects construction management education however related courses involve lectures without engaging students real cases although educational games reported effective motivating students learning limited number studies focused developing realistic negotiation game teaching instrument class developed web based negotiation game named negotiation game enabling students make simulated decisions construction procurement negotiation processes game enables students play role either contractor supplier schedule required procurement evaluate prospective negotiating parties conduct parallel negotiations allocate materials projects manage cash flow game also equipped randomization features assigning random quality performance levels different suppliers experiment conducted using participating students results indicated significant improvement least students posttest scores regardless pretest scores elsevier rights reserved
exploration structural balance social networks great importance theoretical analysis practical use study modeled structural balance social networks mathematical optimization problem using swarm intelligence efficient discrete particle swarm optimization algorithm proposed solve modeled optimization problem take advantage topologies social networks algorithm design discrete representation particle redefined discrete particle update principles redesigned validate efficiency proposed algorithm experiments conducted using synthetic real world social networks experiments demonstrate proposed algorithm achieves balanced social network structure also automatically detects community topology networks
fluctuating wind induced vibration one important factors taken account design long span bridge due low stiffness low natural frequency field measurement characteristics sustained wind structure site provide accurate wind load parameters wind field simulation structural wind resistance design suspension bridge main span runyang suspension bridge rsb high sensitivity fluctuating wind simultaneous continuously wind environment field measurement mid span tower top executed structural health monitoring system installed bridge based recorded data wind characteristic parameters including mean wind speed wind direction turbulence intensity gust factors turbulence integral length power spectrum spatial correlation analyzed detail coherence functions parameters evaluated using statistical method paper results indicate turbulence component sustain wind larger extremely strong winds although mean wind speed smaller correlation turbulence parameters obvious power spectrum special accord simiu spectrum von karman spectrum results obtained study used evaluate long term reliability runyang suspension bridge provide reference values wind resistant design structures region
despite large body literature across multiple disciplines adolescent motherhood adolescent fathers largely absent empirical research previous findings suggest young men experience multiple risk factors across range life domains high likelihood becoming fathers early age negatively impact developmental trajectories age normative transitions school work however little known risk factors fatherhood among high risk juvenile offenders well understood fatherhood related criminal behavior population current study investigated risk factors offending patterns associated adolescent fatherhood status sample serious juvenile offenders consistent previous studies fatherhood status associated greater risk exposure among serious juvenile offenders furthermore change fatherhood status associated higher levels overall offending aggressive offending income related offending non drug related income offending light findings propose supports resources needed facilitate juvenile offenders role fathers time
childhood sexual abuse csa highly prevalent associated wide variety negative mental physical health outcomes school based csa education prevention programs shown promise unclear extent community level characteristics related effectiveness present cluster randomized controlled trial evaluated community level moderators safe lastprogramcomparedtoawaitlistcontrolcondition knowledge gains pre post intervention assessed domains safe versus unsafe people safe choices problem solving clear disclosure assertiveness participants students white african american hispanic asian american grades public schools tennessee multilevel models accounting nesting children within schools revealed large effect sizes intervention versus control across knowledge domains ranged effectiveness program moderated mean per capita income rates substantiated cases child abuse neglect community intervention effects stronger youth living lower compared higher income counties youth attending schools counties lower compared higher abuse neglect rates child characteristics sex race moderate intervention effects research identified two community level factors predicted effectiveness csa education prevention program designed improve children knowledge personal safety skills school based csa prevention programs may require modification communities higher rates child abuse neglect elsevier ltd rights reserved
usage frequency swept signals eddy current metal detector described paper main task researchers minimize false alarms account total alarms better discrimination performed distinguish mine scrap metals firstly short theoretical background presented secondly experimental data measured search head metal detector atmid presented detector excited frequency swept sine signals khz khz synchronous demodulation used signal processing various spheres different materials sizes placed open air used test targets grenade without explosives also presented comparison amplitude phase graphs polar graphs presented differentiate different objects basis polar graphs better identification discrimination different buried objects anti personnel mines undertaken
paper pipelined architecture high speed network security processor nsp ssl tls protocol implemented system chip soc hardware information encryption hashing key exchange algorithms stored secure digital card terms bit files contrary recent ones actually implemented hardware soc works nsp system running application soc security algorithms implemented also provides ethernet communication interface nsp finds applications commerce virtual private network vpn fields require data confidentiality motivation present work dynamically execute applications embedded systems strict resource power budgets maintaining stipulated throughput appropriate cipher suite chosen following proposed preferential algorithm based efficient system index esi budget comprising throughput power resource given user bit files chosen security algorithms downloaded card partial region field programmable gate array fpga proposed soc controls data communication application running system pci ethernet interface network proposed design uses partial reconfiguration feature ise suite zynq fpga platform performances implemented crypto algorithms considerably better terms power throughput resource existing works reported literatures elsevier rights reserved
large scale rainwater harvesting lsrwh promising alternative address security flood issues urban areas development planning lsrwh eco community involves comprehensive site planning systems planning design includes rainwater source collection roof storage tank distribution allocation system paper describes new technique designing lsrwh community houses average persons per house average total daily water demand found optimal size storage tank roof area reliability application model case study revealed significant water saving total cost system usd life span years elsevier rights reserved
terns gluten become commonplace disorders associated gluten still remain poorly understood non celiac gluten sensitivity ncgs recently recognized gluten related disorders arguably unknown celiac disease wheat allergy diagnostic algorithm ncgs remains diagnosis exclusion evidence based objective diagnostic criteria serological tests difficult diagnose even difficult study epidemiologically studies often use varied definitions ncgs difficult compare validate complicating diagnosis ncgs variable vside ranging symptoms overlap number diseases changes diet inherently difficult study fact argued ncgs exist distinct entity may caused gluten portion foods review outline current knowledge hypotheses debates surrounding epidemiology ncgs context spectrum gluten related disorders
research field ambient technology conducted western cultural spheres paper want explore potential approaches designers might take towards ambient systems asian contexts particularly aim exploring role ambience development systems analyzing aesthetic factors vary depending culture observed efficiency environmental factors influence design decisions serve feedback smart technologies authors published elsevier
non contact type force actuator necessary studying dynamic performance high speed spindle system owing high speed operating conditions non contact electromagnetic exciter designed identifying dynamic coefficients journal bearings high speed grinding spindles linear force control method developed based pid controller influence amplitude frequency current misalignment rotational speed magnetic field excitation force investigated based two dimensional finite element analysis electromagnetic excitation force measured auxiliary coils calibrated load cells design validated experimental results theoretical experimental investigations show proposed design accurately generate linear excitation force sufficiently large amplitude higher signal noise ratio moreover fluctuations force amplitude reduced greater extent designed linear control method even air gap changes due rotor vibration high speed conditions besides possible apply various types excitations constant synchronous non synchronous excitation forces based proposed linear control method exciter used linear force exciting controlling system dynamic performance study different high speed rotor bearing systems
cloud computing led path towards revolutionary change modern day computing aspects developments gave way internet things range highly interactive applications paradigm distributed reach also brings forth set challenges form latency sensitive applications quick response highly contributes efficient usage qos quality service fog computing answer challenges rapidly changing distributed computing landscape extending cloud computing paradigm include widespread resources located network edge fog paradigm makes use edge ward devices capable computing networking storage one key impending challenges determine place data analytic operators maximum efficiency least costs network traffic efficient algorithmic solution seek propose way work underway
background autism spectrum disorder asd neurodevelopmental disorder characterized social communication impairments restricted repetitive behaviors whereas current pharmacological interventions asd focus primarily psychiatric symptoms including agitation obsessive behaviors agents target core symptomatology previously hypothesized abnormalities facial scanning reduced eye contact increased mouth fixation contribute social communication deficits asd addition previous reports suggested elevated stress anxiety asd symptoms believed impact facial scanning patterns objectives present pilot study sought explore effects pharmacological intervention via propranolol nonselective beta adrenergic antagonist known anxiolytic facial scanning asd specifically wished determine whether increase eye contact decrease mouth fixation administration propranolol method sample participants asd matched controls participated two study sessions propranolol placebo administered counterbalanced double blinded manner session ocular fixation data collected presentation video stimuli human faces fixation time eye nose mouth regions face stimuli analyzed results baseline fixation patterns asd control groups significantly differ however administration propranolol associated significant reduction mouth fixation asd group additionally mouth fixation positively related nonverbal communication impairment asd group conclusions although eye fixation asd appears typical present study effect propranolol reducing mouth fixation suggests important focus research future studies needed better characterize relationship stress anxiety facial scanning asd well effects pharmacological intervention
openmole scientific workflow engine strong emphasis workload distribution workflows designed using high level domain specific language dsl built top scala exposes natural parallelism constructs easily delegate workload resulting workflow wide range distributed computing environments openmole hides complexity designing complex experiments thanks dsl users embed applications scale pipelines small prototype running desktop computer large scale study harnessing distributed computing infrastructures simply changing single line pipeline definition construction pipeline decoupled execution context high level dsl abstracts underlying execution environment contrary classic shell script based pipelines two aspects allow pipelines shared studies replicated across different computing environments workflows run traditional batch pipelines coupled openmole advanced exploration methods order study behavior application perform automatic parameter tuning work briefly present strong assets openmole detail recent improvements targeting executability workflows across various linux platforms tightly coupled openmole care standalone containerization solution allows executing linux host application packaged another linux host previously solution evaluated python based pipeline involving packages scikit learn well binary dependencies packaged executed successfully various hpc environments identical numerical results prediction scores obtained environment results show pair formed openmole care reliable solution generate reproducible results executable pipelines demonstration flexibility solution showcases three neuroimaging pipelines harnessing distributed computing environments heterogeneous local clusters european grid infrastructure egi
several methods used non surgical sterilization birth control including quinacrine trichloroacetic acid tca erythromycin tetracycline silver nitrate talcum powder among talcum powder tca silver nitrate commonly used however toxic carcinogenic activities chemicals ovarian tissue poorly elucidated study demonstrates expression levels antioxidant apoptotic anti apoptotic genes administration talc powder tca silver nitrate non surgical sterilization female rat models expression changes micrornas mir mir mir mir play key roles apoptosis pathway also included expression analyses evaluated real time pcr expression levels genes appeared upregulated talcum powder group results statistically significant increased expression gsr sod genes statistically significant talcum powder group tca silver nitrate group expression genes appeared elevated gsr expression statistically significant tca administrated group statistically significant changes silver nitrate group mirna expression levels increased talcum powder tca administrated groups results significant expression levels mir mir mir silver nitrate group significantly increased consequently chemicals appear non carcinogenic agents rat ovarian tissue induce apoptosis however talcum powder tca considered agents toxic ovarian tissue
assessing dysphonic symptoms noninvasive effective approach detect parkinson disease patients main purpose study investigate effect different dysphonia measurements detection support vector machine svm seven categories dysphonia measurements considered experimental results ten fold cross validation technique demonstrate vocal fundamental frequency statistics yield highest accuracy dysphonia measurements employed svm classifier achieves accuracy refinement original patterns space removing dysphonia measurements similar variation across healthy subjects allows achieving accuracy latter performance larger reported literature dataset ten fold cross validation technique finally found measures ratio noise tonal components voice suitable dysphonic symptoms detect subjects achieve specificity finding highly promising understanding symptoms elsevier rights reserved
paper presents design compact ghz phase shifter provides bit digital phase control degrees phase range beam forming systems phase shifter designed using proposed cross coupled bridged type topology switched varactor reflective type topology topologies analyzed using small signal equivalent circuit model furthermore design equations derived investigated validate theoretical analysis ghz bit degrees phase shifters designed commercial cmos technology fabricated degrees phase shifter features good performance phase states ghz rms phase error degrees total insertion loss rms gain error better dbm power consumption almost zero best knowledge designed degrees phase shifter size smallest bit passive phase shifter frequencies around ghz
objective little understood regarding disease progression alters immune sensory nerve function colitis investigated acute colitis chronically alters immune recruitment impact activated colitis understand impact disease progress sensory systems investigated mechanisms underlying altered colonic neuro immune interactions acute colitis design inflammation compared mouse models health acute tri nitrobenzene sulphonic acid tnbs colitis remission reactivated colitis cytokine concentrations compared elisa situ explanted colon tissue colonic infiltration cdb macrophage helper cytotoxic alpha beta expression mesenteric lymph node mln determined flow cytometry cytokine effector receptor mrna expression determined colo rectal afferent neurons mechanisms underlying cytokinergic effects high threshold colo rectal afferent function investigated using electrophysiology results colonic damage mpo activity macrophage infiltration beta concentrations lower reactivated compared acute colitis infiltration alpha beta expression mln increased remission acute colitis ifn gamma concentrations infiltration alpha beta expression mln increased reactivated compared acute colitis reactivated explants secreted beta acute explants tnf alpha inhibited colo rectal afferent mechanosensitivity remission mice via bkca dependent mechanism conclusions acute colitis persistently alters immune responses afferent nerve signalling pathways successive episodes colitis findings highlight complexity viscero sensory neuro immune interactions painful remitting relapsing diseases elsevier inc rights reserved
urbanization globally consistently reshaping natural landscape accommodate growing human population urban vegetation plays key role moderating environmental impacts caused urbanization critically important local economic social cultural development differing patterns human population growth varying urban structures development stages results highly varied spatial temporal vegetation patterns particularly pan pacific region fastest urbanization rates globally yet spatially explicit temporal information amount change urban vegetation rarely documented particularly less developed nations remote sensing offers exceptional data source unique perspective map urban vegetation change due consistency ubiquitous nature research assess vegetation fractions cities across pan pacific countries using annual gap free landsat surface reflectance products acquired using sub pixel spectral unmixing approaches vegetation change trends analyzed using mann kendall statistics theil sen slope estimators unmixing results successfully mapped urban vegetation pixels located urban parks forested mountainous regions well agricultural land correlation coefficient ranging greatest vegetation loss found shanghai tianjin dalian china contrast cities including vancouver canada seattle usa showed stable vegetation trends time using temporal trend analysis results suggest possible reduce noise outliers caused phenological changes particularly cropland using dense new landsat time series approaches conclude simple yet effective approaches unmixing landsat time series data assessing spatial temporal changes urban vegetation regional scales provide critical information urban planners anthropogenic studies globally international society photogrammetry remote sensing inc isprs published elsevier rights reserved
investigate dynamics alpha helical proteins dipole quadrupole type molecular excitations performing symbolic computation iterative algorithm darboux transformation present multisoliton solutions resulting fourth order nonlinear schrodinger nls equation study energy sharing properties also study effect disorder inhomogeneity using perturbative technique found inhomogeneity hydrogen bonding spines introduces fluctuations profile solitons without affecting robust nature propagation elsevier rights reserved
accurate service life prediction structures vital taking appropriate measures time cost effective manner however conventional prediction models rely simplified assumptions leading inaccurate estimations paper reviews capability machine learning addressing limitations classical prediction models due ability capture complex physical chemical process deterioration mechanism paper also presents previous researches proposed applicability machine learning assisting durability assessment reinforced concrete structures advantages employing machine learning durability service life assessment reinforced concrete structures also discussed detail growing trend collecting service data using wireless sensors facilitates use machine learning durability service life assessment paper concludes recommending future directions based examination recent advances current practices specific area elsevier rights reserved
following recent global climate changes many countries including developed nations announcing greenhouse gas ghg reduction targets actively participating reducing ghg therefore role building sector reducing ghg emphasized establishment policy structures making environmentally friendly capacity compulsory improving housing quality demanded south korea also developing policy improving housing quality order achieve competitive growth must preceded analysis current policy status within various countries improving housing quality study aims suggest direction policies improve housing quality south korea policies major countries able categorize compare according three major categories performance function aesthetics seven factors safety durability cost maintenance response residents needs habitability energy saving building design regarding housing quality result performance aspect policy directions suggested safe housing urban environment regeneration quality stock usage existing stock functional aspect policies improving housing quality responds aging population energy saving housing suggested aesthetic aspect housing designs consider urban environment suggested
object detection classification countless applications human robot interacting systems necessary skill autonomous robots perform tasks household scenarios despite great advances deep learning computer vision social robots performing non trivial tasks usually spend time finding modeling objects working real scenarios means dealing constant environment changes relatively low quality sensor data due distance objects often found ambient intelligence systems equipped different sensors also benefit ability find objects enabling inform humans location applications succeed systems need detect objects may potentially contain objects working relatively low resolution sensor data passive learning architecture sensors designed order take advantage multimodal information obtained using rgb camera trained semantic language models main contribution architecture lies improvement performance sensor conditions low resolution high light variations using combination image labeling word semantics tests performed stages architecture compare solution current research labeling techniques application autonomous social robot working apartment results obtained demonstrate proposed sensor architecture outperforms state art approaches
paper presents development new hydraulic hybrid vehicle based laboratory course mechanical industrial manufacturing engineering department university toledo objective provide educative tool undergraduate students advance research hydraulic hybrid vehicle technology educative module based problem solving learning approach aids students gaining richer understanding elements courses mechanical engineering curriculum fluid dynamics hydraulics energy stems vibrations mechatronics controls additionally modules developed hydraulic hybrid system become available internet universities utilize laboratory also serves research tool advancement hydraulic hybrid vehicle technology end graduate undergraduate students performing experiments simulations enhance understanding hydraulic hybrid systems knowledge obtained utilized help optimize design hydraulic hybrid vehicle technologies
background urine biomarkers helped identify persons risk progressing kidney disease setting hiv infection explored factors associated changes urine biomarkers years among women living hiv methods prospective cohort hiv infected women multicenter women interagency hiv study predictors included hiv viral immunological parameters comorbid conditions health related behaviors outcomes patterns changes urine interleukin albumin creatinine ratio acr alpha microglobulin alpha years used quantile regression examine patterns change urine biomarker follow multivariable analysis variance regression identify predictors biomarker changes results years median concentrations declined alpha rose acr remained stable multivariate analyses strongest predictors increases higher baseline body mass index increase waist circumference higher follow hiv viral load lower follow cell count hepatitis virus hcv coinfection higher follow high density lipoprotein cholesterol predictors increasing concentration lower cell counts higher diastolic blood pressure hcv coinfection smoking finally determinants acr increases follow higher follow diastolic blood pressure hcv coinfection higher follow hiv viral load triglyceride concentration conclusions years hiv disease status different associations urine biomarker study overall associations changes biomarker support research use longitudinal monitoring kidney health
background controversy ongoing interest measurement functionality personal social level objectives validate greek version world health organization disability assessment schedule das determine added value physical psychological health subscales short form methods cross sectional design data collected december march using three questionnaires das pss sample people disabilities without disabilities athens greece das internal consistency construct criterion related validity assessed cronbach alpha exploratory factor analysis correlations added value multivariable linear regression results cronbach alpha satisfactory das pss respectively exploratory factor analysis confirmed existence one two factors people without disabilities respectively das score showed significant negative correlation physical mental health scale score especially strong physical health positively related pss score multivariate analysis mental health appraisal related perceived stress groups conclusions study support validity greek version das warranted use assessment follow people disabilities contributing development suitable policies cover needs providing comparable data surveys using instrument elsevier inc rights reserved
paper focuses simultaneous optimization heat integrated water allocation networks mathematic model established illustrate modified state space representation problem easy logical method employed help identify streams hot cold ones model water exchange networks wen heat exchange networks hen interactions wen hen combine together one unity thus whole network solved one time enhances possibility get global optimal result examples literature pvc plant analyzed illustrate accuracy applicability method
chronic diarrhoea common entity daily clinical practice leads loss patients quality life may main symptom multiple ethiologies including bile acid malabsorption bam comparable prevalence celiac disease bam results imbalances homeostasis bile acids enterohepatic circulation consequence ileal disease ileal dysfunction bam type considered idiopathic primary bam type associated gastrointestinal entities bam type among different diagnostic methods available sehcat study primary current method due sensitivity specificity safety low cost main disadvantage available countries diagnostic methods appeared serum measurement fgf however significantly complex costly first line treatment bile acid diarrhoea bile acid sequestrant cholestyramine difficult administer due poor tolerability gastrointestinal side effects less prominent newer agents colesevelam summary bam common entity underdiagnosed undertreated essential establish diagnosis algorithm chronic diarrhoea sehcat study would first second line differential diagnosis patients elsevier espana semnim rights reserved
korea experienced ever increasing numbers women entering labor force rural families particularly impacted transitions may shift family dynamics power evidenced couples decision making patterns longitudinal panel study rural korean farm nonfarm households examines degree couples decision making practices changed decade along three dimensions agricultural work family life domestic work wives farm households significantly increased participation joint decision making agricultural work family life however money management decisions remained mostly husbands farm nonfarm households husbands participation domestic work decision making unchanged even though increased involvement childcare house cleaning implications offered policy makers practitioners working rural korean families benefits women empowerment equality couples decision making
chronic subdural hematoma csdh one common intracranial hematomas worldwide high incidence general population however optimum treatment csdh burr hole drainage without rinse considering poor outcomes csdh aged patients ambiguous prediction recurrence many sides recurrent csdhs analyzed new effective therapies needed csdhs predicated poor prognosis surgery higher risk recurrence statins first line treatment patients high cholesterol coronary heart disease however statins still solely limited treatment diseases demonstrated statins could improve csdh due effect regulation angiogenesis inflammation review order provide potential new treatment csdh summarize recent findings statins csdh order try clarify mechanisms effect
control systems among important subsystems ability undertake indispensable functions safety critical systems since many key components systems follow different performance degradation paths therefore important approach capable correctly estimating performance control systems containing variety degraded components one solution endow existing estimation approach equip capability cope uncertainties inadequate system specifications paper presents hybrid model capable improving existing approaches applying laplace transform time varying model control system taking account varying behaviors components different time slices reliability estimated event based monte carlo simulation require knowledge exact reliability function system reliability improved using particle swarm optimization method method searches optimal parameters control strategy compensating loss effectiveness caused degraded components proposed approach validated case study conducted simulated cooling system numerical results shown proposed approach capable improving reliability control systems subject total run time constraints
background several studies demonstrated adjuvant therapies exercise breathing training effective improving cardiac autonomic control cac patients affective spectrum disorders however effects sudarshan kriya yoga sky autonomic function population unknown objective test hypothesis sky training improves cac cardiorespiratory coupling patients anxiety depression disorders methods forty six patients diagnosis anxiety depression disorders dsm consecutively enrolled divided two groups conventional therapy control conventional therapy associated sky treatment days anxiety depression levels determined using quantitative questionnaires assessment cac cardiorespiratory coupling cardiorespiratory traces analyzed using monovariate bivariate autoregressive spectral analysis respectively results days observed reduction anxiety depression levels treatment group moreover sympathetic modulation cac significantly lower parasympathetic modulation cardiorespiratory coupling significantly higher treatment compared control group conclusions intensive breathing training using sky approach improves anxiety depressive disorders well cac cardiorespiratory coupling finding suggest sky training may useful non pharmacological intervention improve symptoms reduce cardiovascular risk patients anxiety depression disorders
emergence smart materials urged design education keep take part introducing design students great deal work teaching conventional materials like wood metal polymers product design yet comes learning smart materials sources limited research group delft university technology initiated number projects particularly focusing understanding technical experiential characteristics smart materials materials design mission communicate smart material qualities pre design tinkering activities functional demonstrators also serve source inspiration paper explain approach example case electroluminescent materials
stealth technology one significant ways guarantee radar survivability stealth algorithm mimo radar searching mode obtained improve stealth performance algorithm based stealth optimization model sets number subarrays average power dwell time search frame period controllable parameters interception factor also considered optimize stealth performance guarantee searching performance simulation results show mimo radar stealth algorithm searching mode better stealth performance conventional phased array radar
objective compare fathers mothers perceptions impact severity child food allergy levels involvement allergy related care methods one hundred parents children food allergy mother father pairs rated severity child food allergies completed food allergy impact scale subset parents reported often engaged food allergy related care results mothers reported impact fathers meal preparation family social activities stress free time significantly greater involvement allergy related care fathers reported frequent medical appointment attendance perceived meal preparation significantly impacted food allergy fathers less involved conclusions fathers less involved may buffered experiencing impact child health condition differences involvement rather gender differences may explain discrepancies mothers fathers illness perceptions
purpose quality life qol consists health psychological well communication related domains due heterogeneous nature parkinson disease important examine effects different domains including motor cognitive performance motor speech performance among set individuals existing studies indicate mixed findings due use different qol measures lack general consensus regarding qol components method present study examined self proxy ratings individuals voice handicap index vhi pdq mobility determine effects speech motor related qol respectively result good level agreement self proxy ratings pdq mobility ratings alone addition overall group differences found self proxy ratings vhi pdq mobility ratings thus indicating similar perceptions individuals communication partners speech motor related changes associated significant correlations speech motor related qol found thereby suggesting domains independent conclusion present study indicates need consider self proxy reports understand impact person overall functioning
purpose present study investigate differences media violence exposure groups adolescents without disruptive behavior disorders aggressive features using case controlled design multimethod assessment samples adolescents aged disruptive behavior disorder aggressive features age gender matched controls completed semistructured interview exposure violence television video games parents completed corresponding questionnaire measure moderate intercorrelations found self parent report television video game violence exposure measures compared control adolescents adolescents disruptive behavior disorder aggressive features higher aggregate media violence exposure higher exposure video game violence higher parent reported exposure television violence results show adolescents parents agree adolescent level media violence exposure exposure violence television tends accompanied exposure violence video games association media violence exposure disruptive behavior disorder aggressive features due spurious effect gender wiley liss inc
tidal notches generally accepted sea level marker maintain particular interest palaeoseismic studies since coastal seismic activity potentially displaces genetic position result subsequent seismic events notch sequence reflecting cumulative coastal uplift order evaluate preserved notch sequences innovative interdisciplinary workflow presented accurately highlights evidence palaeo sea level markers workflow uses data terrestrial laser scanning iteratively combines high resolution curvature analysis high performance edge detection feature extraction based assumptions remnants roof tidal notches form convex patterns edge detection performed principal curvature images addition standard algorithm compared edge detection results custom fuzzy logic approach results pass hough transform order extract continuous line features almost horizontal orientation workflow initially developed single distinct sheltered exposure southern crete afterwards successfully tested laser scans different coastal cliffs perachora peninsula approach allows detailed examination otherwise inaccessible locations evaluation lateral geometries thus evidence previously unrecognised sea level markers identified even poorly developed high resolution laser scans entire cliff exposures allow local variations quantified edge detection aims reduce information surface curvature hough transform limits results towards orientation continuity thus presented objective methodology enhances recognition tidal notches supports palaeoseismic studies contributing spatial information accurate measurements horizontal movements beyond recognised traditional surveys especially useful identification palaeo shorelines extensional tectonic environments coseismic footwall uplift net slip per event unlikely raise entire notch tidal range elsevier rights reserved
determine diagnostic value signal within sacroiliac joint space spondyloarthritis spa retrospective analysis mris joints performed patients aged years clinically suspected sacroiliitis intra articular joint signals categorized normal high signal fluid signal ankylosis vacuum phenomenon mri findings correlated final diagnosis according asas criteria sensitivity specificity positive negative likelihood ratios predictive values calculated presence intra articular high signal fluid signal ankylosis specificity spa high signal fluid signal ankylosis present spa patients patients without spa resulting respectively present spa patients patients without spa resulting presence high signal fluid signal ankylosis within joint mri high specificity spa high signal sensitive mri feature within joint spa aeuro cent mri joints typically obtained diagnosis spondyloarthritis aeuro cent signal within joint reflects features spondyloarthritis aeuro cent intra articular high signal fluid signal ankylosis seen spondyloarthritis aeuro cent vacuum phenomenon makes spondyloarthritis less likely
objectives previous sports injury known risk factor subsequent osteoarthritis population based rates sports injury unknown aims study describe trends population incidence burden hospital treated sports injury victoria australia adults aged years determine incidence lower limb knee injuries quantify population health burden average direct hospital costs per injury lengths stay methods health sector data relating adults aged years inclusive extracted victorian admitted episodes dataset vaed victorian emergency minimum dataset vemd data relating sports injuries identified using activity codes dataset trends injury frequency rates determined economic burden calculated results overall annual rate hospital treated sports injuries increased lower limb injuries years associated accumulated economic burden million sports injuries million lower limb injuries years conclusions findings study show significant increase sports injuries state victoria australia year period previous sports injury risk factor development future incidence escalate placing even greater burden health care systems population wide preventative strategies reduce risk sports injury urgently required order reduce future burden osteoarthritis research society international published elsevier ltd rights reserved
validate hol model arm cortex microcontroller core testing model behaviour randomly chosen instructions real chips several manufacturers model intended application involve precise timing information instruction execution implementations pipelined checking behaviour single instructions would give sufficient confidence model thus test model using sequences randomly chosen instructions main challenge meet constraints initial intermediate execution states must ensure memory accesses range respect restrictions instructions careful transformation constraints shelf smt solver used find suitable states executing test sequences also use additional constraints test hypotheses timing anomalies encountered elsevier rights reserved
introduction trastuzumab related cardiotoxicity major concern clinical practice since observational studies shown higher incidences reported clinical trials aim measure incidence trastuzumab related cardiotoxicity patients early metastatic breast cancer south brazil methods multicenter prospective observational study included patients early metastatic breast cancer undergoing trastuzumab based regimen cardiac events measured transthoracic echocardiography assessments signs symptoms heart failure results trastuzumab related cardiotoxicity observed patients emergency hospitalization admissions necessary seven three patients respectively due symptoms heart failure one patient died consequence trastuzumab related cardiotoxicity total trastuzumab discontinued patients almost third could return treatment study risk factors significantly associated development cardiotoxicity discussion incidence trc trastuzumab early discontinuation observed significantly higher comparison studies findings endorse fact trastuzumab related cardiotoxicity relevant adverse reaction therefore cardiac dysfunction monitoring must highlighted order allow safe use trastuzumab population
paper presents framework strapdown inertial navigation system ins algorithm design using lie group lie algebra general way solve lie group differential equations introduced investigations reveal general lie group method provides simpler unified way solve differential equations involving direction cosine matrix quaternion dual quaternion widely used ins algorithm design furthermore also present new ins algorithm based special euclidean group guidelines lie group method analyses show algorithm accuracy dual quaternion algorithm also justified numerical simulations though algorithm improvements accuracy general lie group method used design process shows brevity uniformity
investigate influence premature birth conditions among children aged years national survey children health usa added question premature birth first time wave influence born premature different conditions controlling sociodemographic factors assessed using logistic regression total children aged years born premature compared children born premature born premature likely cerebral palsy odds ratio confidence interval vision problems hearing problems special healthcare need children born premature increased likelihood sports team taking sports lessons school weekends past months born premature prematurity may associated negative outcomes infants transition childhood adolescence interventions within life course perspective needed alleviate long term consequences prematurity
water quality planning complicated challenged existence uncertainties nonlinearities terms model formulation solution study simulation based inexact two stage chance constraint quadratic programming sitcqp approach developed water quality management sitcqp model hybrid two stage stochastic programming tsp chance constraint programming ccp inexact quadratic programming iqp multisegment stream water quality simulation water quality simulation model provided reflecting relationship pollution control actions wastewater discharge environmental responses discharge interval quadratic polynomials employed reflect uncertainties nonlinearities associated costs wastewater treatment uncertainties derived water quality standards characterized random variables normal distributions proposed approach applied hypothetical case water quality management modeling solutions presented combinations deterministic interval distributional information could facilitate predictions different forms uncertainties results valuable helping decision makers generate alternatives wastewater treatment stream water quality management
background individuals borderline personality disorder bpd frequently display morbid mental disorders disorders include internalizing disorders major depressive disorder anxiety disorders externalizing disorders substance use disorders antisocial personality disorder hypothesized disorders may arise latent internalizing externalizing liability factors factor analytic studies suggest internalizing externalizing factors contribute bpd extent contributions familial unknown method participants probands bpd without bpd major depressive disorder siblings parents probands participants administered diagnostic interview dsm personality disorders revised diagnostic interview borderlines structured clinical interview dsm results confirmatory factor analysis within person associations disorders bpd loaded moderately internalizing factor loading externalizing latent variables within family associations assessed using structural equation models familial non familial factors bpd internalizing disorders externalizing disorders cholesky decomposition model association bpd internalizing externalizing factors accounted familial contributions conclusions familial internalizing externalizing liability factors associated therefore may mutually contribute bpd familial contributions account largely pattern morbidity bpd internalizing externalizing disorders
modeling simulation gene regulatory networks grns become important aspect modern systems biology investigations mechanisms underlying gene regulation key task area automated inference reverse engineering dynamic mechanistic grn models gene expression time course data besides lack suitable data particular multi condition data system one key challenges task computational complexity involved genes grn system parameters grn model higher computational load computational challenge likely increase substantially near future tackle larger grn systems goal study develop distributed computing framework system reverse engineering grn models present resulting software called multigrain mapper software based new architecture tools supporting multiscale computing distributed computing environment key feature multigrain mapper realization grn reverse engineering based underlying distributed computing framework multi swarm particle swarm optimization demonstrate features multigrain mapper evaluate performance using real artificial gene expression data elsevier rights reserved
utilizing surveillance data five sites participating autism developmental disabilities monitoring network investigated contributions surveillance subject census tract population sociodemographic characteristics variation autism spectrum disorder ascertainment prevalence estimates using ordinal hierarchical models tracts multivariable analyses showed significant increase ascertainment autism spectrum disorder cases school health sources optimal ascertainment scenario cases college educated mothers adjusted odds ratio confidence interval results examination sociodemographic factors tract populations cases drawn also showed controlling covariates statistical significance remained associations optimal ascertainment percentage hispanic residents adjusted odds ratio confidence interval percentage residents least bachelor degree adjusted odds ratio confidence interval identified sociodemographic factors associated autism spectrum disorder prevalence estimates including race ethnicity education income determining specific factors influence disparities complicated however appears even presence education racial ethnic disparities still apparent results suggest disparities access autism spectrum disorder assessments special education autism spectrum disorder among ethnic groups may impact subsequent surveillance
background hereditary angioedema hae due inhibitor deficiency manifests recurrent swelling attacks disabling sometimes fatal long term prophylaxis twice weekly intravenous injections plasma derived inhibitor pdc inh established effective treatment subcutaneous administration pdc inh studied patients hae methods open label dose ranging crossover study compact phase conducted patients type hae received two twice weekly doses highly concentrated volume reduced csl weeks mean trough plasma levels inh functional activity inh antigen levels week overall safety tolerability evaluated primary outcome model derived steady state trough inh functional activity results csl administration dose dependent increase trough functional inh activity observed inh levels increased two highest dose groups achieved constant inh activity levels values threshold assumed provide clinical protection angioedema attacks compared intravenous injection pdc inh injection csl showed lower peak trough ratio consistent exposures doses well tolerated mild moderate local site reactions noted pain swelling common adverse event conclusions subcutaneous volume reduced csl well tolerated led dose dependent increase physiologically relevant functional inh plasma levels clinical outcome study csl patients hae warrants investigation
introduction ischemic heart disease ihd major cause death disability among western countries angina pectoris prevalent symptomatic manifestation strategies improve management chronic stable angina priority areas covered comprehensive review conducted using medline cochrane databases well clinical trial databases united states europe traditional therapies angina discussed review particularly emphasizes investigational therapies angina including pharmacological agents cell gene based therapies herbal medications expert opinion renewed interest older anti angina agents perhexiline amiodarone phosphodiestrase inhibitors anti inflammatory agents allopurinol febuxostat currently undergoing evaluation angina therapy therapeutic angiogenesis continues face challenges future trials evaluate optimum patient population would benefit form therapy
parents children autism spectrum disorder asd report concerns child compliance development compliance month old high risk children asd outcomes high risk children without asd low risk children examined high risk asd group showed greater passive noncompliance months non asd groups smaller increase compliance high risk asd group high risk asd group also showed smaller decline active noncompliance low risk group controlling receptive language passive noncompliance findings nonsignificant whereas compliance active noncompliance findings retained significance growth compliance attenuated children asd changes passive noncompliance part associated language comprehension
high frequency models electrical motors power converters greatly important electromagnetic compatibility characterization electrical drives electromagnetic interference emi filter design paper accurate effective method characterization tuning models khz mhz induction motors proposed based experimental measurements motor impedance impedance measurements taken three different configurations six winding terminals shorted grounded three input terminals shorted grounded common mode one input terminal two shorted differential mode motor model structure chosen modeled using state space representation parameters tuned using genetic algorithm match real impedance corresponding configuration comparison experimental impedance measurements model impedance estimate shown tested configurations order validate model within frequency range interest emi
block compressed sensing bcs image compressed encrypted simultaneously novel reversible data hiding rdh method proposed embed additional data bcs encrypted images proposed method based image block edge pixel separation every block used data embedding special measurement flipping decryption considering correlation natural images fluctuation function used find flipped block realise data extraction image recovery experiments show proposed method outperform existing rdh method bcs images
paper presents supplied bulk driven symmetrical ota implemented cmos process operating weak inversion using distributed layout approach ota benefit voltage reduction high linearity enabled halo implanted transistors proposed circuit consumes features low transconductance total harmonic distortion input voltage thus making suitable low frequency low power applications
multitude contemporary applications involve graph data whose size continuously grows trend shows signs subsiding caused emergence many distributed graph processing systems including pre gel apache giraph however unprecedented scale reached real world graphs hardens task graph processing even distributed environments current memory usage patterns rapidly become primary concern contemporary graph processing systems seek address challenge exploiting empirically observed properties demonstrated graphs generated human activity paper propose three space efficient adjacency list representations applied distributed graph processing system suggested compact representations reduce respective memory requirements accommodating graph elements times compared state art methods time memory optimized methods retain efficiency uncompressed structures enable execution algorithms large scale graphs settings contemporary alternative structures fail due memory errors
development advanced control methods based robustness optimality prediction important challenging task recent years new control approaches emerged replace augment conventional control engineering methods paper presents design verification comparison three advanced methods imc mpc plm applied control dynamic processes complex dynamics paper three different methods tested applied position control pneumatic servodrives presented tested methods guarantee robust stability high performance pneumatic servodrives control
water flow porous media involved physical factors size configuration pores contact angle grain surface connectivity pores deal factors pore scale modeling essential pore aggregate referred pore network extracted randomly packed spherical grains modified delaunay tessellation method water flow pore network formulated terms network flow problem hydraulics friction local losses contraction enlargement pipes explicitly treated implicitly included hydraulic conductance capillary tubes existing works numerical experiments confirmed effect local loss hydraulic conductivity could negligible furthermore relative permeabilities porous media mixed wettabilities along primary drainage imbibition processes estimated
paper presents empirical assessment productivity changes within korean construction management industry using non parametric malmquist bootstrap methodology purposes paper global malmquist productivity index mpig based productivity measurement procedure designed evaluate changes productivity within market uses data public announcements related capabilities productivity estimates statistically verified using bootstrapping method result estimations study showed despite quantitative industry wide growth average productivity service business firms korean industry increase total productivity korean firms affected environmental factors including changes businesses cycle industry decreases firm managerial strategic capabilities resulted parallel decline firm actual productivity despite technical advances market efforts promote technical efficiency among firms however could overcome technological declines market
work focuses review particle based multiscale hybrid methods surfaced field fluid mechanics last years consider five established particle methods molecular dynamics direct simulation monte carlo lattice boltzmann method dissipative particle dynamics smoothed particle hydrodynamics general description given particle method conjunction multiscale hybrid applications analysis length scale separation revealed current multiscale methods bridge across scales order work complex geometries parallel code optimisation needed increase separation similarities methods highlighted combinations discussed advantages disadvantages applications particle method tabulated reference
paper presents conversion electric cargo vehicle portable platform interacting information applications cargo vehicle hosts seats driver extra passenger interactive systems installed cargo right left back exterior side vehicle intended follow predefined routes central ports nearest city center making long term stops stops embedded interactive systems entertain provide visitors passersby information local interest papers focuses vehicle conversion process installation necessary hardware components needed interactive systems development portable control panel designed address driver needs
analytical study examined importance nonverbal communication law enforcement work many encounters police citizens primary focus always suspects citizens verbal statements rather body conveying telling story study argues integrated approach police officers need realise communicating nonverbally suspects study reveals nonverbal communication also known body language proxemic kinesics behavior many cases tends constitute much larger fraction police communication model verbal communication help officers establish authority dominance ensure safety nonverbal communication something added onto criminal justice rather essence criminal justice results suggest nonverbal communication foundation successful relationship encounter criminal justice personnel suspects criminals well powerful method feigned
objectives parallel increase incidence obesity diabetes well number daily meals however evidence lacking regarding role intermittent fasting aim study determine effects ramadan model intermittent fasting rif daytime abstinence food drinking body composition glucose metabolism cognitive function methods ten healthy lean men included nonrandomized crossover intervention study testing performed control period well rif whole body dual energy ray absorptiometry magnetic resonance imaging abdomen fitness test oral glucose tolerance test cognitive function tests performed secondary outcome participants physical activity glycemic responses monitored within periods dietary intake appetite mood questionnaires also assessed results comparing differences testing days body mass index changes control period mean confidence interval rif period mean significantly different secondary outcomes within rif period showed increased area curve auc hunger accompanied reduced auc satiety less mean steps per day less positive feelings afternoon compared control period changes observed evaluated parameters conclusions free living participants able comply daily daytime abstinence food drinking minor effect body mass index without effects body composition glucose metabolism cognitive function authors published elsevier inc
sexual health plays important role well university students literature shows majority university undergraduates sexually active high risk contracting sexually transmitted infections stis however breadth degree literature sexual health knowledge unclear purpose scoping review gain deeper understanding state research sexual health knowledge university college students globally stage framework used guide review characterize literature sexual health knowledge articles published english reviewed included university students population interest described methods used measure sexual health knowledge articles retrieved met criteria majority articles used cross sectional design investigate students knowledge hiv aids stis hpv contraception review highlights gaps literature findings relating research dominance various geographic locations common research designs wide range measurement tools used variety sexual health knowledge outcomes interest review provides useful description literature sexual health knowledge among university college students recommendations moving field forward
quality performances compensation harmonic currents depends strongly performances identification blocks control side photovoltaic generators used active filters use harmonics identification methods valid network voltage must sinusoidal balanced case practice hence make application identification methods harmonic currents versatile voltage form use detection system fundamental component direct voltage paper comparison conventional method used extracting direct component network voltage based phase locked loop pll new approach based multivariable extraction filter finally simulation results show proposed multivariable filter may better work even network voltage perturbed unbalanced furthermore filters permits generalize use identification methods filtering different perturbations active reactive current authors published elsevier ltd
urban geological hazards involving ground instability costly dangerous affect many people yet little information extent distribution geohazards within europe urban areas reason impracticality measuring ground instability associated many geohazard processes often hidden beneath buildings imperceptible conventional geological survey detection techniques satellite radar interferometry insar offers remote sensing technique map scale grotind deformation wide areas given archive suitable multi temporal data space project named pangeo used insar map areas unstable ground europe cities representing similar population partnership europe national geological surveys pangeo project developed standardised geohazard mapping methodology recorded instances types geohazard covering presented analysis results pangeo project output data provides insights distribution european urban geohazards frequency probability occurrence merging pangeo data eurostat geostat data provides systematic estimate population exposures satellite radar interferometry shown valuable tool systematic detection mapping urban geohazard phenomena elsevier rights reserved
philadelphia negative myeloproliferative neoplasms include polycythaemia vera essential thrombocytopenia primary myelofibrosis pmf patients conditions mainly thought harbour jakvf mutations myeloproliferative leukaemia mpl substitution two revolutionary studies identified recurrent mutations gene encodes protein calreticulin calr mutation detected patients pmf non mutated jak mpl absent patients calr gene encodes calreticulin protein multifactorial protein mainly located endoplasmic reticulum chromosome regulates calcium homeostasis chaperones also implicated multiple cellular processes including cell signalling regulation gene expression cell adhesion autoimmunity apoptosis somatic deletions recurrent insertion mutations calr detected resulted frameshift clusters exon gene review summarise current knowledge calr gene mutation gene pathological conditions patient phenotypes
impaired glycogen synthesis turnover common insulin resistance type diabetes glycogen synthase key enzyme involved synthetic process presents promising therapeutic target treatment type diabetes present study identified novel potent orally available activator ajs sodium difluoro methylsulfanyl phenyl phenoxy methyl furan carbonyl furylmethyl amino acetate vitro performed glycogen synthase gys activation assay screening activators identified activity ajs potentiated presence glucose phosphate vivo used mice evaluate novel anti diabetic effects ajs measuring basal blood glucose levels glucose tolerance body fat mass index repeated administration ajs weeks reduced blood glucose hemoglobin hbac levels mice ajs also improved glucose tolerance dose dependent manner decreased body fat mass mrna levels genes involved mitochondrial fatty acid oxidation mitochondrial biogenesis elevated skeletal muscle tissue following ajs treatment hepatic tissue treated mice also exhibited elevated expression genes associated fatty acid oxidation contrast mice cbl mice ajs administration alter body weight reduce glucose levels results demonstrate pharmacological agents activate gys main subtype found skeletal muscle potential use novel treatments diabetes improve glucose metabolism skeletal muscle
stone column useful method increasing bearing capacity reducing settlements foundations confinement provided native soft soils effective influence stone column bearing capacity paper laboratory tests performed unreinforced reinforced geotextile encased stone columns tests performed columns diameters length diameter ratio vertical encased stone columns vesc horizontal reinforced stone columns hrsc used stone column reinforcement investigate effect reinforcement type bearing capacity main objective research study efficiency vesc hrsc conditions diameters experimental results show bearing capacity stone columns increases using vertical horizontal reinforcing material moreover bearing capacity reinforced stone columns increases increasing strength reinforcement vesc hrsc results show bulging failure mechanism governed tests lateral bulging decreases using geotextiles increasing strength reinforcement addition vesc hrsc stress concentration ratio columns also increases
article investigates gender differences participation voluntary organizations across life course italy shows three forms engagement voluntary organizations donating money attending meetings unpaid work may depend stages life course leaving parental home forming union becoming parent plausible may change personal resources pose constraints provide opportunities involvement using household survey istat multipurpose survey aspects daily life article finds leaving parental home positively associated men women involvement forming union parent detrimental women involvement men pattern indicates gender roles may constrain women men probability participation voluntary organizations
fully polarizable multipolar atomistic force field protein fflux built machine learning kriging models predicts atomic property atom given protein geometry needs assigned kriging model knowledgeable atom needs informed sufficiently large environment around resulting complexity tackled collecting natural amino acids groups using substituted deca alanines present proof concept given atom charge modeled kriging models wiley periodicals inc
previous research animals indicates flavonoid compounds immunomodulatory properties however human research remains inconclusive aim systematic review assess efficacy dietary flavonoids upper respiratory tract infections urtis immune function healthy adults created search strategy run cochrane central register controlled trials medline embase embase classic cinahl amed returned studies initially screened reviewers independently assessed remaining studies eligibility prespecified criteria fourteen studies initially identified included review primary outcome measure effect flavonoids urti incidence duration severity included studies flavonoid supplementation ranged overall flavonoid supplementation decreased urti incidence compared control apparent adverse effects sick day count decreased flavonoid supplementation although unclear differences bio immune markers interleukin tumor necrosis factor alpha interferon gamma neutrophils trivial intervention control groups intervention exercise postintervention exercise bout included findings suggest flavonoids viable supplement decrease urti incidence otherwise healthy population
recovered memory therapy rmt controversial largely practice regarded many memory experts highly suggestible however know little public regards practices sample college students randomly assigned watch videotaped enactments series therapy sessions client eventually reported recovered memory childhood sexual abuse therapy conditions identical except level suggestiveness employed therapist control expectation guided imagery hypnosis results indicated participants expectation guided imagery hypnosis groups saw therapist significantly suggestive control condition however participants judged competency therapist veracity memory reports equally high across conditions findings suggest lay public may recognize suggestive practices therapists engaged rmt fail see relation accuracy memories reported clients question competence therapist
wimax offers new parading regards way traditional wireless network systems designed happens due impact generating technology society impact environmental ambient intelligence smart cities sidi bouzid area fundamental technological advantages wimax superior radio technological advantages wimax superior radio technology built qos security open based access network infrastructure technology used number applications including last mile broadband connections hotsposts high speed connectivity business customers objective article propose approach design network latest standard wimax namely use dimensioning planning network sidi bouzid area order optimize interferences noise avoide cutout article review wimax technology given followed standard focusing standard design approach developed help network planner work achieve smart city sidi bouzid communications approach summarized simple flow chart case study network based technology designed sidi bouzid area number subscriber calculated district area plotted clutter map building penetration losses type area modeled using several measurements conducted part work fact tried minimize noise evry kind interference design outcome number base station distribution found less existing ones operating network
basic graph structures maximal independent sets mis spurred much theoretical research randomized distributed algorithms several applications networking distributed computing well however extant distributed algorithms problems necessarily guarantee fault tolerance load balance properties propose study low average degree sparse versions structures interestingly sharp contrast say mis shown checking whether structure sparse take substantial time nevertheless able develop good sequential distributed randomized algorithms sparse versions also complement algorithms several lower bounds randomization plays key role upper lower bound results wiley periodicals inc random struct alg
introduction neuropeptide nps residue peptide endogenous ligand nps receptor npsr receptor formerly orphan gpcr whose activation increases calcium cyclic adenosine monophosphate levels nps npsr system expressed several brain regions controls important biological functions including locomotor activity arousal sleep anxiety food intake memory pain drug addiction areas covered review furnishes updated overview patent literature covering npsr ligands since first example npsr antagonist disclosed expert opinion several potent npsr antagonists available valuable pharmacological tools despite showing suboptimal pharmacokinetic properties vivo optimization ligands needed speed potential clinical advancement pharmaceuticals treat drug addiction order support design novel npsr antagonists performed ligand based conformational analysis recognizing structural requirements npsr antagonism identification small molecule npsr agonists represents unmet challenge addressed molecules allow investigation beneficial effects selective npsr activation large panel psychiatric disorders foresee therapeutic potential anxiolytics nootropics analgesics
study temperature viscosity dependent methods used identify main heat conduction mechanism nanofluids three sets experiments conducted investigate effects brownian motion aggregation image processing approach used identify detailed configurations different nanofluids microstructures thermal conductivity nanofluids measured respect dynamic viscosity temperature range degrees results clearly indicated nanoparticle brownian motion play significant role heat conduction nanofluids also supported observation viscous sample rendered higher thermal conductivity moreover microscopic pictures differences viscosity theoretical experimental values suggested major role particle aggregation clustering elsevier ltd rights reserved
face face communication communication online environments convey information beyond actual verbal message traditional face face conversation paralanguage ancillary meaning emotion laden aspects speech actual verbal prose gives contextual information allows interactors appropriately understand message conveyed paper conceptualize textual paralanguage tpl define written manifestations nonverbal audible tactile visual elements supplement replace written language expressed words symbols images punctuation demarcations combination elements develop typology textual paralanguage using data twitter facebook instagram present conceptual framework antecedents consequences brands use textual paralanguage implications theory practice discussed published elsevier inc behalf society consumer psychology
first study assess fungal diversity mycotoxigenic fungi open recirculating cooling tower water systems biofilm water phase production capability mycotoxin fungal isolates also examined mean fungal count different water biofilm samples determined cfu cfu total species identified internal transcribed spacer sequencing common isolated fungi belonged genera aspergillus penicillium prevalent fungi aspergillus versicolor aspergillus niger penicillium dipodomyicola surveyed cts aflatoxigenic flavus isolates identified detection opportunistic pathogens allergen species suggests open recirculating cts possible source fungal infection public occupational workers via inhalation aerosols skin contact
nonlinear similarity measures defined kernel space correntropy extract higher order statistics data offer potentially significant performance improvement linear counterparts especially non gaussian signal processing machine learning paper propose new similarity measure kernel space called kernel risk sensitive loss krsl provide important properties apply krsl adaptive filtering investigate robustness develop mkrsl algorithm analyze mean square convergence performance compared correntropy krsl offer efficient performance surface thereby enabling gradient based method achieve faster convergence speed higher accuracy still maintaining robustness outliers theoretical analysis results superior performance new algorithm confirmed simulation
work performance dual chamber microbial fuel cells mfcs constructed either commonly used nafion proton exchange membrane supported ionic liquid membranes silms assessed behavior mfcs followed analyzed taking polarization curves besides efficiency characterized measuring electricity generation using various substrates acetate glucose using silms containing either mirn bmiml ntf ionic liquids energy production mfcs glucose comparable obtained mfc employing polymeric nafion substrate furthermore mfc operated bmim ntf based silm demonstrated higher energy yield case low acetate loading codin one polymeric nafion codin significant difference observed two silm mfcs however characteristics system similar based cell polarization measurements results suggest membrane engineering applying ionic liquids interesting subject field bioelectrochemical system research elsevier ltd rights reserved
emerging nanoscale silicon photonics advances fabrication integration chip cmos compatible optical elements good news system designers optical network chips onocs could next generation nocs hand hybrid opto electrical networks may provide higher bandwidth lower latency better power dissipation considering optical electrical characteristics multicore platforms cluster based technique locally connects processing cores electrical interconnect clusters connected together optical waveguide experimental results show benchmark applications cluster size proves appropriate size optimizing energy delay product edp parameter
paper describes effect embedment depth bearing capacity footing supported geocell reinforced bed using plate load test diameter embedment depth ratio footing varied zero plate load tests performed outdoor test pit dug natural ground measuring plan depth geocell used tests non perforated pocket size height fabricated continuous polypropylene filaments nonwoven geotextile tests conducted geocell reinforced bed sand compacted relative density test results demonstrate bearing pressure increases increase embedment depth ratio number geocell layers study also compares embedment depth ratio one layer geocell reinforcement two three layer geocell reinforcement bed embedment depth comparisons show performance footing single layer reinforced bed embedment depth ratio might comparable performance footing geocell reinforced bed two three reinforcement layers authors published elsevier
digital dead beat current controller voltage source converters presented paper control structure specified digital hardware description language synthesized deployed field programmable gate array chip updating negligible computation delay duty cycle twice switching period reference current error nulled half modulation period controller small signal bandwidth maximized addition due simple transient detection circuit large signal response delay reduced small fraction modulation period determined chosen current signal oversampling rate controller effectively support different voltage source inverter applications active filters uninterruptible power supplies microgrid distributed energy resource controllers converter applications including interface converters renewable energy sources laboratory battery chargers electronic welding machines
introduction unwanted mental intrusions umi constitute normal variants obsessions obsessive compulsive disorder ocd preoccupations defects body dysmorphic disorder bdd images illness hypochondriasis hyp thoughts eating eating disorders eds sought investigate relationships frequency discomfort associated experience four umi contents adopting within subject perspective method group university students community participants mage women completed questionnaire unpleasant intrusive thoughts assess frequency discomfort four umi contents related ocd bdd hyp eds results participants reported experienced four sets intrusions related frequent least disturbing whereas hyp intrusions least frequent disturbing four umi significantly related frequency discomfort women experienced ocd bdd related intrusions frequently men age negatively associated frequency distress four umis conclusions umis might transdiagnostic variable across different disorders ocd bdd eds hypochondriasis might contribute explaining phenomenological similarities among
hydrogen utilization spark ignition engines could reduce urban pollution including particulate matter well greenhouse gas emission however backfiring undesirable combustion process intake charge hydrogen fueled engine manifold based injection one major technical issues view safety engine operation backfiring occurs generally suction stroke hydrogen air charge interacts residual gas resulting flame growth propagation toward upstream engine intake manifold resulting stalling engine operation high risk safety work aimed analysis backfiring hydrogen fueled engine results indicate backfiring mainly function residual gas temperature start hydrogen injection timing equivalence ratio hot spot present cylinder would act ignition source resulting chances backfiring addition computational fluid dynamics cfd analysis carried order assess flow characteristics hydrogen air suction stroke intake manifold furthermore numerical analysis intake charge velocity flame speed deflagration flame propagation backfiring toward upstream intake manifold also carried notable points backfiring control strategy including exhaust gas recirculation egr retarded late hydrogen injection timing emerged study minimizing chance backfiring study results useful development dedicated engine hydrogen fuel aspects elimination backfiring
thermodynamic characteristics formation schiff base isoniazid pyridoxal phosphate aqueous solution different values medium determined means spectrophotometry calorimetric titration process kinetics studied spectrophotometrically reaction rate constants formation imine different acidities medium determined biochemical aspects binding pyridoxal phosphate stable compounds discussed
introduce new class models stochastic volatility moving average errors conditional mean state space representation moving average component however means errors measurement equation longer serially independent estimation becomes difficult develop posterior simulator builds upon recent advances precision based algorithms estimating new models empirical application involving inflation find moving average stochastic volatility models provide better sample fitness sample forecast performance standard variants stochastic volatility elsevier rights reserved
lameness one important causes poor welfare poultry previous studies documented approximately chickens seriously lame research novel technique developed early detection lameness broilers purpose broiler chickens five different predefined gait scores continuously monitored digital camera walked throughout test corridor image analysis algorithm applied detect feature variables speed step frequency step length lateral body oscillation broilers afterwards correlation test performed define coefficient correlation feature variables step frequency step length speed lbo obtained proposed algorithm gait score levels birds respectively resulted furthermore feature variable investigated find statistical differences gait scores measure lameness broilers performed assess effects gait score speed step length step frequency lateral body oscillations broilers results showed investigated feature variables efficacious detect lameness broilers starting since correlations found feature variables step frequency step length speed lbo obtained proposed algorithm gait score levels birds one hand statistical differences gait score levels broilers hand results recommend fully automated detection system potential used real time monitoring tool early detection lameness broilers starting however define lower gait scores either new feature variables like foot curls wing use inserted proposed system system combined automatic behaviour analysis tools early detection lameness future research important detect lameness early stage allows farmers veterinarians take immediate management actions time elsevier rights reserved
wake global financial crisis societies across world attempting manage potentially destabilizing levels youth unemployment underemployment new terms entered popular lexicon generation jobless new underclass precariat order describe generation young people struggling acquire secure livelihoods dismal labor market since great depression article draws analytical resources critical sociology education heterodox political economy order critique orthodox economic diagnoses generational precarity human capital problem argues neo keynesian accounts provide important corrective certain aspects conventional neoclassical neoliberal viewpoints ultimately fall short explanatory power marxian analysis particularly concerning primacy class relations contradictory role employment within increasingly crisis ridden global capitalism
study proposes simple control scheme using single stage flyback ssf converters lighting source applications leds among advantages average current mode current ripple one half critical conduction mode crm condition helps extend output capacitor lifetime lowering input emi capacitance input emi capacitance ssf converter proposed study operates continuous conduction mode ccm addition two sample hold circuits placed output voltage loop feed forward path respectively since circuits access average output current average feed forward voltage led driver unaffected ripple noise total harmonic distortion thd reduced transient response output current improved finally operation principles design considerations studied led driver analyzed discussed laboratory prototype also designed tested verify feasibility copyright john wiley sons ltd
past research demonstrated perceivers spontaneously infer individuals goals beliefs traits behaviors inferences processes essential predicting others future behaviors thus smooth social interaction given social roles professor mother also predictive individual future behaviors proposed perceivers spontaneously infer individuals social roles behaviors across three experiments including two different paradigms documented perceivers formed spontaneous role inferences sris single behaviors sris occurred unintentionally efficiently important downstream consequences impression formation namely sris led perceivers rate targets higher role consistent traits together findings provide first empirical demonstration novel process impression formation published elsevier inc
leydig cell number function decline men age low testosterone associated western cardio metabolic disorders however whether perturbed androgen action within adult leydig cell lineage predisposes individuals late onset degeneration remains unknown address generated novel mouse model androgen receptor ablated similar adult leydig stem cell cell progenitors fetal life onward leydig cell knockout mice permitting interrogation specific roles autocrine leydig cell signaling comparison adjacent retaining leydig cells testes littermate controls human testes including patients complete androgen insensitivity syndrome cais revealed autocrine signaling dispensable attainment final leydig cell number essential leydig cell maturation regulation steroidogenic enzymes adulthood furthermore studies reveal autocrine signaling leydig cells protects late onset degeneration seminiferous epithelium mice inhibits leydig cell apoptosis adult mice patients cais possibly via opposing aberrant estrogen signaling conclude autocrine androgen action within leydig cells essential lifelong support spermatogenesis development lifelong health leydig cells
sleep duration progressively fallen last years obesity increased past years several studies reported association chronic sleep deprivation long term weight gain increased energy intake due sleep loss listed main mechanism consequences chronic sleep deprivation energy expenditure fully explored sleep body weight mood behavior subjected circannual changes however modern environment seasonal changes light ambient temperature attenuated seasonality defined cyclic changes mood behavior stable personality trait strong genetic component hypothesize attenuation seasonal changes environment may produce negative consequences especially individuals predisposed seasonality women seasonal affective disorder condition common women characterized depressed mood hypersomnia weight gain carbohydrate craving winter represents extreme example seasonality one postulated functions sleep energy preservation hibernation phenomenon characterized decreased energy expenditure changes state arousal may offer useful insight mechanisms behind energy preservation sleep goals article consider contribution changes energy expenditure weight gain due sleep loss review phenomena seasonality hibernation neuroendocrine mechanisms relate sleep energy expenditure body weight regulation endocrinol invest editrice kurtis
alzheimer disease multifactorial fatal neurodegenerative disorder characterized decline cholinergic function deregulation neurotransmitter systems beta amyloid fibril deposition beta amyloid oligomers formation based involvement relevant number biological systems alzheimer disease progression multitarget compounds may enable therapeutic efficacy accordingly compounds possessing besides anticholinergic activity beta amyloid aggregation inhibition properties metal chelating nitric oxide releasing properties additional antioxidant capacity developed targets relevant alzheimer disease also considered last years producing multitarget compounds beta secretase monoamino oxidases serotonin receptors sigma receptors purpose review highlight recent reports development multitarget compounds alzheimer disease published within last years focusing multifunctional ligands characterized tacrine like donepezil like structures elsevier ltd rights reserved
osteoporosis disease characterized degradation bone structures various methods developed diagnose osteoporosis measuring bone mineral density bmd patients however bmds methods equivalent incomparable addition partial volume effect introduces errors estimating bone volume computed tomography images using image segmentation study two compartment model tcm proposed calculate bone volume fraction bmd images tcm considers bones composed two sub materials various equivalent bmd calculated applying corresponding sub material pairs tcm contrast image segmentation tcm prevented influence partial volume effect calculating volume percentage sub material image voxel validations tcm performed using bone equivalent uniform phantoms printed trabecul arstructural phantom temporal bone flap abdominal images using tcm calculated tvs uniform phantoms within percent errors percent errors structural volumes various slice thickness volume temporal bone flap close micro images percent error significant difference found areal bmd lumbar vertebrae calculated using tcm measured using dual energy ray absorptiometry conclusion proposed tcm could applied diagnose osteoporosis providing basis comparing various measurement methods
objectivesto examine dose response relationships habitual physical activity bone health elderly designlongitudinal settingcommunity nakanojo participantscommunity living japanese aged men women measurementsdaily pedometer accelerometer data collected continuously years quantitative calcaneal osteosonic index osi determined annually resultsyear end osi values higher greater daily step counts especially greater duration activity metabolic equivalents mets however controlling baseline osi age body mass final osi values significantly greater fourth third activity quartile men women respectively took means steps day exercised intensity mets means min day multivariate adjusted proportional hazards model predicted osi values men women respectively times likely drop osi fracture threshold years two lowest activity quartiles steps day steps day min day mets conclusionafter adjustment potential confounders calcaneal health seniors associated daily step count duration activity intensity mets bone health optimal elderly people take least steps day spend least min day intensity mets
objective identify factors associated treatment modality selection acoustic neuromas study design prospective observational study setting tertiary care neurotology clinic patients data prospectively collected patients initially presenting tertiary care neurotology clinic patients magnetic resonance imaging mri demographic psychometric audiometric data excluded analysis intervention demographic information clinical symptoms tumor characteristics psychometric data collected determine factors associated undergoing acoustic neuroma surgical resection using univariate multiple logistic regression analysis main outcome measure decision pursue acoustic neuroma surgical resection versus active surveillance results total patients acoustic neuroma mean age years women included ninety eight patients pursued surgical resection patients pursued active surveillance surgical treatment significantly associated patient age less higher grade tumors growing tumors larger volume tumors lower word discrimination scores class hearing headache vertigo presenting symptoms higher number total symptoms higher headache severity scores significant association surgical intervention preoperative quality life depression self esteem scores multiple logistic regression analysis likelihood undergoing surgical resection significantly decreased patients older age odds ratio increased patients medium moderately large large grade tumors tumor growth present class hearing higher headache severity scores confidence interval likelihood undergoing surgical resection completely predictive giant grade tumors significant small grade tumors class hearing conclusions non elderly acoustic neuroma patients larger tumors growing tumors significant hearing loss worse headaches likely pursue surgical resection rather active surveillance psychological factors quality life depression self esteem seem influence decision making patient population
purpose paper introduce investigate new application hydrogen special internal combustion engine free piston engine generator development full cycle zero dimensional dynamic simulation model described extensive coupled research method presented iteration simulation zero dimensional dynamic model multi dimensional computational fluid dynamics engine model combustion process giving insight operating characteristics performances new hydrogen fueled engine influences piston motion combustion process analyzed performance characteristics new hydrogen engine found differ significantly corresponding traditional hydrogen engine free piston gasoline engine results indicate compared mentioned traditional hydrogen engine free piston hydrogen engine higher piston acceleration around top dead center tdc advantage terms emissions formation due faster power stroke expansion indicated efficiency slightly lower due longer late combustion process moreover indicated efficiency combustion velocity peak pressure larger compared free piston engine combusting gasoline concentration emission also advantage copyright hydrogen energy publications llc published elsevier ltd rights reserved
ventromedial prefrontal cortex vmpfc implicated wide array functions across multiple domains review focus vmpfc involvement mediating strategic aspects memory retrieval memory related schema functions decision making suggest vmpfc generates confidence signal informs decisions memory guided behaviour confidence central seemingly diverse functions strategic retrieval lesions vmpfc impair early automatic intuitive monitoring process feeling rightness often associated confabulation spontaneous reporting erroneous memories critically confabulators typically demonstrate high levels confidence false memories suggesting faulty monitoring following vmpfc damage may lead indiscriminate confidence signals memory schemas vmpfc critically involved instantiating maintaining contextually relevant schemas broadly defined higher level knowledge structures encapsulate lower level representational elements correspondence memory retrieval cues activated schemas leads monitoring stronger elaborate schemas produce stronger influence confidence veracity memory candidates finally review evidence vmpfc role decision making extending role decision making memory retrieval non mnemonic mnemonic decision making vmpfc automatically encodes confidence confidence signal vmpfc revealed non linear relationship first order monitoring assessment second order action choice attempting integrate multiple functions vmpfc propose posterior anterior organizational principle region posterior vmpfc regions involved earlier automatic subjective contextually sensitive functions anterior regions involved controlled actions based earlier functions confidence signals reflect non linear relationship first order posterior mediated second order anterior mediated processes represented along entire axis elsevier ltd rights reserved
hydrogen promising energy carrier port fuel injection pfi fuel flexible durable relatively cheap method energy conversion however combustion knock abnormal combustion phenomenon limit brake torque thermal efficiency also breaks piston engines paper uses four stoke cycle displacement pfi hydrogen internal combustion engine calculated model study inducing factors frequency combustion knock results showed combustion knock occurs relatively higher engine speed min engine speed occurring knock gasoline engine calculated average temperatures air fuel mixture end combustion using thermodynamics dual zone model fall range hydrogen engines higher gasoline ones knock abnormal combustion phenomena backfire pre ignite interact backfire generates components cylinder heated next cycle components cylinder release heat intake increase initial temperature ignition high initial temperature lead combustion knock otherwise combustion knock temperatures cylinder components increase generates hot spots ultimately causes pre ignite backfire figures fast fourier transform fft amplitude frequency hydrogen engines higher gasoline ones every kind mode pressure waves combustion knock spread radial direction light combustion knock circumferential direction heavy combustion knock conclusions used explore working conditions close combustion knock achieve higher thermal efficiency provide guidance detect knock hydrogen engine hydrogen energy publications llc published elsevier ltd rights reserved
definition modern family changing case study describe breastfeeding experience child receiving human milk mothers adoptive mothers induced lactation nurse birth mother shared early feeding open adoption process continued pump send milk several months review lactation protocol used adoptive mothers unique difficulties inherent multi mother family dynamic adoptive mothers successfully induced moderate milk production using combination hormonal birth control domperidone herbal supplements schedule breast pumping however increased complexity immediate postpartum period concerns defining parental roles sex marriage maintenance milk production difficult
objective aim concept mapping study identify structure alleged importance perpetuating factors functional somatic symptoms fss perspective professionals examined extent factors addressed scientific literature methods ninety nine perpetuating factors sorted respect content using card sorting task experienced clinicians psychologists female mean age years mean duration experience treating fss patients years factors derived fromin depth interviews clinicians extensive experience treating fss thirty eight clinicians rated importance factors scale ranging important extremely important results hierarchical cluster analysis revealed three overarching domains perpetuating factors hypochondria social relational problems symptom related emotions habits domains comprised clusters rated importance adverse physical factors counterproductive lifestyle frustration despair regarding symptoms clusters addressed scientific literature conclusions study revealed encompassing hierarchical structure somatic emotional cognitive behavioral social factors importance perpetuation fss based expert opinions structure guide development personalized treatment fss elsevier inc rights reserved
using damping ratios inferred accelerations recorded earthquakes instrumented buildings california paper evaluates rayleigh damping model commonly used seismic analysis buildings damping ratios obtained seismic responses coming buildings measured earthquakes past years california strong motion instrumentation program records analyzed using least squares parametric system identification technique time domain using damping ratios judged reliable variation damping modal frequencies studied buildings found cases modal damping ratios increase approximately linearly frequency showing damping buildings best represented using model consisting constant damping ratio plus stiffness proportional damping ratio evidence found suggest mass proportional model combination mass stiffness proportional damping appropriate shown rayleigh damping model used combination assumptions commonly used engineering practice typically leads overestimations mean peak floor accelerations peak floor velocities interstory drift ratio demands respect computed using damping model inferred recorded data elsevier ltd rights reserved
paper aims explaining large scale energy intensive industries german iron steel industry period slow uptake major energy efficient technologies mid mid arens worrell mid onwards technologies increasingly implemented analyze underlying factors investment innovation behavior individual firms german iron steel industry better understand barriers drivers technological change paper gives insights decision making process energy efficiency firms helps understand policy affects decision making use mixed method approach first analyze diffusion three energy efficient technologies eet primary steelmaking introduction today top pressure recovery turbine trt basic oxygen furnace gas recovery bofgr pulverized coal injection pci derive uptake technologies national level level individual firm second analyze impact drivers barriers decision making process individual firms whether want implement technologies economics access capital foremost barriers uptake eet expected payback period exceeds certain value company lacks capital investments eet seem happen even eet economically viable company access capital investments eet might realized policy induced prices might strengthened recent diffusion trt found indications limited number cases policy intervention driving factor technical risks imperfect information marginal factors cases site specific factors seem important site specific factors shape economics selected eet
background aims hepatocellular carcinoma hcc prognostic scores could useful addition barcelona clinic liver cancer bclc system clarify patient prognosis guide treatment decision niace tumor nodularity infiltrative nature tumor serum alpha fetoprotein level child pugh stage ecog performance status score distinguishes different prognosis groups among bclc hcc patients aims evaluate niace score additive value two hcc cohorts treated either surgery chemoembolization according bclc recommendations patients methods retrospective multicenter study two bclc hcc cohorts treated either surgery chemoembolization carried studied survival time according baseline niace score compared cancer liver italian program score bclc system results niace score differentiates subgroups patients different prognosis within bclc class among bclc patients treated surgery bclc patients treated chemoembolization niace score differentiates two subgroups significant difference survival time months versus months months versus months respectively among subgroups niace score significantly better prognostic value bclc system cancer liver italian program score conclusion study among hcc patients treated according bclc recommendations niace score predicts accurately system survival time copyright wolters kluwer health inc rights reserved
prosperity location based services lbss makes people pay close attention personal privacy order preserve users privacy several schemes utilized trusted third party ttp obfuscate users schemes suspected ttp may become single point failure service performance bottleneck alleviate suspicion schemes collaborative users achieve anonymity proposed schemes users equipped short range communication devices could communicate adjacent users establish anonymous group group user obfuscate hide behind least users however schemes usually effcient snapshot services continuous ones cope inadequacy help caching mobile devices propose query information blocks random exchange results caching scheme short caqbe scheme particular user hidden behind collaborative users snapshot service caches preserve privacy continuous service case active adversary launching query correlation attack passive adversary launching impersonation attack random collaborative user selection random block exchange algorithm also utilized based feature entropy metric measure privacy user attacks active passive adversaries proposed finally security analysis experimental comparison similar schemes verify optimal scheme effectiveness preservation effciency performance
coco peat powder cpd main product coconut palm excellent source environmentally friendly magnetic sorbent potential application oil spill cleanup order develop best resource agricultural crop alleviate environmental stress caused disposal natural cpd feo nanoparticles immobilized coco peat powder cpd aid mussel inspired polydopamine pda chemically modified low surface energy octadecylamine oda fabricate novel magnetic coco peat powder mcpd selective oil water separation obtained mcpi high hydrophobicity water contact angle degrees saturation magnetization emu exhibited remarkable sorption efficiency convenient removal oils water displayed excellent separating performance auxiliary magnetic field results indicated highest amount oil sorption mcpd reached times weight oil could desorbed oil loaded mcpd easily recycled least cycles oil loaded mcpd also exhibited high recyclability loss less oil sorption capacity cycles suggests mcpd prepared proposed synthesis process high potential application large scale removal spilled oils water work also provides universal strategy developing oil pollution treatment using natural resources waste stream elsevier rights reserved
paper presents statistical simulation study channel step finfet due work function variability depending grain orientation metal gate statistical fluctuation induced metal gate granularity threshold voltage sigma current sigma current sigma estimated wide range channel length effective fin width varying average grain size using technology computer aided design simulator investigated effect grain magnitude variability also shapes various electrical parameters distribution results indicate sigma decreases increase dimension device value sigma ion sigma ioff reduces channel length increases however sigma ion sigma ioff increase fin width increases distribution electrical parameters near normal small grain size becomes bimodal large grain size proposed structure shows excellent behavior terms threshold voltage subthreshold swing current ratio compared conventional finfet high temperature found hot carrier effect reduces increased effective channel width
practice providing property tax assessment incentives within green building sector empirically documented encourage growth green buildings however definite uniform basis adopted development incentive models additionally incentives require local authorities bear implementation costs therefore aim paper develop property tax assessment incentive models evaluation effects tax revenue local authorities amount tax imposed properties taxpayers two incentive models developed paper namely property tax assessment exemption model reduction model cost benefits analysis amount tax assessment increment annual energy savings conveyed green envelope components conducted determine appropriate percentage reduction exemption model local authorities experience increment existing tax revenue taxpayers increased amount tax imposed properties however reduction model local authorities experience tax increment existing tax revenue taxpayers annual energy savings conveyed green envelope components compensate amount tax increment elsevier ltd rights reserved
objectives ulipristal acetate upa introduced contraceptive sexual health services service june algorithm developed guide method selection aim encourage clinicians assess risk offer copper intrauterine device iud first line choice hormonal methods second line choice methods upa second line choice presentations hours high risk episodes around time ovulation women lower risk also offered upa presentation hours unprotected intercourse unless risk low case levonorgestrel second line choice results prior protocol women offered iud compared afterwards improved subgroup women high risk offered iud compared initially introduction upa percentage women accepting iud fell overall women received upa compared receiving iud conclusions introduction standardised protocol provision emergency contraception significantly increased proportion women offered iud postcoital contraception particularly women high risk conception introduction upa seen halving number women accepting iud cause concern investigation reasons behind decrease iud uptake needs undertaken
tensile tests carried demagnetization steel samples loading state magnetic memory characteristics analyzed experimental results show mean magnetic field intensity mmfi measuring point effective measuring points stage study tensile magnetic memory characteristics demagnetization steel samples elastic deformation stage mmfi measuring points one fracture side increases decreases fracture side mmfi decreases distance fracture location change rate mmfi almost equal variation law shows changes opposite direction strengthening phase relation mmfi tensile displacement similar plastic deformation stage variation amplitude accelerated obviously comparison steel shows standard deviation variation magnetic field intensity tensile displacement increases tensile strength materials increases demagnetization bearing components weak areas estimated according breaking laws monitoring points set pre breaks could found appearance inflection point mmfi monitoring point inflection point mean curve breakpoint
paper examines problem systems redesign within context passive electrical networks considering problem multi parameter topology changes representation representation may used investigate impact changes properties characteristic frequencies general problem area modelling systems whose structure fixed evolves system life cycle specific problem addressing study effect changing topology electrical network changing individual elements network elements different type value augmenting eliminating parts network developing framework allows study effect transformations natural frequencies problem special case general network redesign problem use impedance admittance models establish representation different types transformations models representation structural transformations given terms companion pencil preserves natural topologies rlc network
objective study examine prevalence factors associated sexual problems relationship health related quality life hrqol male female non hodgkin lymphoma nhl survivors cross sectional study nhl survivors men women mean time since diagnosis years south korea completed six item instrument adult sexual behavior used national health social life survey united states hrqol measured two subscales eortc qlq sexual problems reported greater proportion women range men range among four items common sexes three lacking interest sex unable achieve orgasm sex pleasurable significantly prevalent women significant factors associated multiple sexual problems men older age unemployed women marital status comorbidity lastly significant associations sexual problems hrqol observed men women male female nhl survivors differ prevalence sexual problems factors associated well associations hrqol findings used develop sex specific interventions improve sexual function population
elucidate difference ratios nurse consultation sought senior rheumatologists junior physicians rheumatology residency training also evaluate physician efficiency index respecting patients rheumatoid arthritis data regarding outpatient visits patients november extracted mean interval day consultations nurse physician visits ratio physician efficiency index nurse physician visits ratio mean interval senior junior physicians calculated disease activity score joints reactive protein das crp health assessment questionnaire haq scores used monitor treatment outcome therefore das haq scores measured times firstly physician consultation nurse consultation finally third visit either nurse physician consultation visits visits planned physicians specialists junior physicians included numbers visits belonged patients among patients female mean age years das baseline nurse physician visits ratio mean efficiency index senior rheumatologists significantly higher junior physicians regression analysis showed positive correlation physician postgraduate experience physician efficiency index adjusted das baseline number patients physician regression coefficient confidence interval high correlation physicians postgraduate experience year ratio nurse physician visits also physician efficiency index nurse consultation contribute worsening treatment outcome since das haq scores significantly decreased physician visits followed nurse visits das haq junior physicians supervised refer patients milder sufficient treatment plan nurses entire department operates efficiently leading prevent additional expenses due differences yearly salary physicians nurses human resource waste quality care monitored markers disease activity crp
paper describes analog signal processing technique development novel electronic circuit embedded photodiode sensor integrated circuit board electronic signal processing detect energy centre optical signal represents accurate position measurement light emitter source mounted structure like buildings bridges mines optical scanning sensor structural health monitoring shm proposed due fact signal processing stage embedded sensor require additional software processing reducing time memory spacing requirements information recording theoretical principle operation technological experimental aspects design development validation presented
mobile healthcare mhealth systems use mobile smartphones portable sensor kits provide improved affordable healthcare solutions underserved communities individuals reduced mobility need regular monitoring architectural constraints systems provide variety computing challenges distributed nature system mobility persons devices involved asynchrony communication security integrity authenticity data collected plethora administrative domains legacy installed electronic health medical systems volume data collected large together data large amount metadata well argue certain metadata essential interpreting data assessing quality great variety kinds medical data metadata methods collected administrative constraints may stored suggest need flexible distributed data repositories also concerns veracity data well interesting questions owns data may access argue traditional notions relational databases security techniques access control encryption communications inadequate instead end end systematic sensor cloud information flow techniques need applied integrity secrecy need adapted towork volume diversity data collected federated collection administrative domains data different domains subject different information flow policies
number computer vision problems facial age estimation crowd counting pose estimation solved learning regression mapping low level imagery features show visual regression substantially improved two stage regression imagery features first mapped attribute space explicitly models latent correlations across continuously changing output propose approach automatically discover spectral attributes avoids manual work required defining hand crafted attribute representations visual attribute regression outperforms direct visual regression spectral attribute visual regression achieves state art accuracy multiple applications
autism spectrum disorder currently lacks explanation bridges cognitive computational neural domains past years progress sought area drawing bayesian probability theory describe social nonsocial aspects autism terms systematic differences processing sensory information brain present article begins synthesizing existing literature regard including introduction topic unfamiliar readers key proposal autism characterized greater weighting sensory information updating probabilistic representations environment unpack hierarchical setting bayesian inference brain predictive processing adds significant depth approach particular autism may relate finer mechanisms involved context sensitive adjustment sensory weightings neural representations environmental volatility inform perception crucially light recent sensorimotor treatments predictive processing active inference hypotheses regarding atypical sensory weighting autism direct implications regulation action behavior given core features autism relate individual interacts samples world around reduced social responding repetitive behaviors motor impairments atypical visual sampling extension bayesian theories autism action critical yielding insights condition
magnetorheological fluid kind smart material paper magnetorheological fluid applied flexible die rheological properties changed rapidly magnetic field sheet metal forming process bulge tests using kind fluid mrf carried self designed experimental device stainless steel crniti combined different process parameters adopted investigate effect property fluid formability material tested results showed fluid utilized successfully pressure carrying medium sheet forming process rheological properties fluid greatly influence dome height thickness strain distribution specimens
although may expected employee perception risk impacts engagement safety behavior previous research equivocal purpose present study clarify relationship via thorough measurement risk perception specifically study investigated value using risk perception measure makes risk perception conditional behavior addition investigating cognitive affective risk perception another purpose study investigate lack supervisor commitment safety affects employees safety behaviors eighty individuals participated laboratory study performed two seemingly dangerous tasks supervisor commitment safety manipulated safety behavior assessed using video data results suggest risk perception framed regard risk performing safety procedures related safety behavior supervisor commitment safety implications findings discussed including need measures make risk perception conditional behavior published elsevier ltd
pilot study designed measure teamwork relationship teamwork patient perceptions care among members oncology teams cancer centre midwest lack teamwork cancer care result serious clinical errors fragmentation care poor quality care many oncology team members highly skilled clinical care trained work effectively members care team research team administered relational coordination survey core oncology team membersmedical oncologists nurse coordinators clinical secretariesto measure seven dimensions team skills four relating communication frequency timeliness accuracy problem solving three relating relationship shared goals shared knowledge mutual respect averaged create relational coordination index results indicated among team member roles nurse coordinator relational coordination indices strongest positively correlated patient perception care statistically significant correlations intra nurse coordinator relational coordination indices two patient perception care factors information education patient preferences nurse coordinator intra role well inter role correlations also positively correlated although statistically significant
considerable evidence suggests adolescent exposure delta tetrahydrocanabinol thc psychoactive component marijuana increases risk developing schizophrenia related symptoms early adulthood present study used combination behavioral molecular analyses vivo neuronal electrophysiology compare long termeffects adolescent versus adulthood thc exposure rats report adolescent adult thc exposure induces long term neuropsychiatric like phenotypes similar observed clinical populations thus adolescent thc exposure induced behavioral abnormalities resembling positive negative schizophrenia related endophenotypes state neuronal hyperactivity mesocorticolimbic dopamine pathway furthermore observed profound alterations several prefrontal cortical molecular pathways consistent sub cortical daergic dysregulation findings demonstrate profound dissociation relative risk profiles adolescent versus adulthood exposure thc terms neuronal behavioral molecular markers resembling neuropsychiatric pathology
aabstracts technical writing genre functions mere summary situated beginning academic report writing considered important site promotes draws readers attention read disregard paper often writers tend use evaluative language abstracts convey stance disciplinary knowledge making convince readers value study study investigates authorial stance engagement readers postgraduate theses abstracts consists corpus mphil phd online theses abstracts chinese students departments electronic engineering computer engineering information technology manufacturing engineering engineering management hong kong university analysis texts based four parameters evaluation texts proposed thomson hunston namely good bad positive negative parameter certainty parameter importance parameter expectedness parameter findings show evaluative language signaling worth study writer certainty knowledge claim good bad parameter mostly used corpus study also discusses implications technical communication pedagogy
purpose review currently much interest numbers glomeruli podocytes interest stems greater understanding effects suboptimal fetal events nephron endowment associations low nephron number chronic cardiovascular kidney disease adults emergence podocyte depletion hypothesis recent findings obtaining accurate precise estimates glomerular podocyte number proven surprisingly difficult whole kidneys large tissue samples available design based stereological methods considered gold standard based principles negate systematic bias however methods often tedious time consuming oftentimes inapplicable dealing small samples biopsies therefore novel methods suitable small tissue samples innovative approaches facilitate high throughput measurements mri estimate glomerular number flow cytometry estimate podocyte number recently described summary review describes current gold standard methods estimating glomerular podocyte number well methods developed past years better placed ever accurately precisely estimate glomerular podocyte number examine relationships measurements kidney health disease
objective determine effect medical treatment work disability patients active psa real world setting methods four hundred patients active psa commencing switching anti tnf conventional synthetic dmard csdmard recruited multicentre prospective observational cohort study work disability measured using work productivity activity specific health problem instrument peripheral joint activity measured disease activity psa composite measure results four hundred patients recruited working age sixty two patients working age unemployed months improvement presenteeism improvement work productivity among working patients commenced csdmards larger rapid improvement presenteeism improvement work productivity among commenced anti tnf therapy clinical response poor among patients commenced csdmard point improvement disease activity psa commenced anti tnf therapy point improvement conclusion report significant clinically meaningful improvements work disability clinical outcomes commencement anti tnf therapy real world setting improvements outcomes among commencing csdmards slower smaller magnitude
sparked growing pollution issues research aiming better harvesting solar energy photo catalysts environmental remediation thriving study novel mixed valence state nanoparticles full spectrum responsive photocatalytic activity fabricated via facile solvothermal route synthesized samples systematically characterized scanning electron microscopy sem transmission electron microscopy tem ray diffraction xrd ray photoelectron spectroscopy xps vis nir diffuse reflection spectroscopy vis nir drs photocatalytic performance obtained samples investigated degradation methylene blue aqueous solution nanoparticles particle size could degrade efficiency light visible light near infrared light exposure respectively furthermore possible photocatalytic mechanism toward near infrared region proposed redox couple played vital parts photocatalytic activity study provides novel full solar spectrum responsive photocatalyst solar light utility environmental remediation elsevier rights reserved
nowadays industry present several areas like automotive telecommunications finance medicine pharmaceutics etc one main problems development domains lack highly qualified specialists thus loosing million euros projects afferent taxes among specialists significant segment allocated programmers testers order train specialists universities introduced several programs including distance learning evening courses problem students get weak results limited class face face learning amount time use learning management systems based learning objects ameliorate problem generative learning objects glo instantiable generic templates generate concrete learning objects considered second generation learning objects used several learning areas like economy accounting medical science nursing computer science understanding programming help robots paper present set generative models designed learning computer programming disciplines order enable accessibility enhanced understanding creativity stimulation computer programming designed set generative models based glo paradigm obtaining automatically concrete los focus set providing models glo authors less programming skills together feature automatic instantiation based random number generators models designed data structure disciplines context developing programming competences namely program using data structures like arrays lists trees graphs
article uses intersectionality lens explore experiences race gender sexuality class intersections associated depression unmet need mental healthcare population women transgender gender liminal people ontario canada survey collecting demographic information information mental health use mental healthcare services data everyday discrimination scale phq questionnaire depression completed people via internet pen paper june june bivariate regression analyses conducted assess group differences depression discrimination experiences predictors depression unmet need mental healthcare services analyses revealed race gender class sexuality corresponded significant differences exposure discrimination experiences depression unmet needs mental healthcare use interaction terms model intersecting identities exclusion contributed explained variance outcome variables everyday discrimination strongest predictor depression unmet need mental healthcare results suggest lower income intersections race marginalised identities associated depression unmet need mental healthcare however discrimination factor contributes vulnerabilities future research build intersectionality theory foregrounding role structural inequities discrimination promoting poor mental health barriers healthcare
context ykl inflammatory biomarker endothelial dysfunction may role kawasaki disease objectives investigated association serum ykl levels established laboratory parameters ykl levels inflammatory markers methods ykl levels inflammatory markers patients disease control patients age matched healthy controls results ykl concentration serum patients significantly increased acute disease phase compared disease controls healthy controls conclusions increased ykl levels may provide useful inflammatory marker patients
paper presents new accessory drive system hybrid electric vehicles hevs new concept involves dual winding electric machine simultaneous motor generator functions electric machine provides power accessory loads steering pump compressors loads engine electric machine starts motoring action provides mechanical power accessory loads simultaneously generator windings provide power loads proposed structure could viable choice fault tolerant applications concentrated winding type maintains electrical magnetic isolation design considerations proposed electric machine outlined paper distributed winding topology concentrated winding topologies also compared analytical proof magnetic decoupling presented experimentally verified
introduction myeloproliferative neoplasms mpn aspirin reduces thrombotic risk nevertheless aspirin resistance may due excessive platelet production turnover resistance aspirin resistance also result lack effect aspirin second component called intrinsic resistance two biological tests considered reference methods assessment aspirin resistance txb assay light transmittance aggregometry lta arachidonic acid materials methods compared third method multiple electrode aggregometry mea performed arachidonic acid multiplate analyzer reference methods thirty six patients mpn assessed aspirin resistance three techniques patients devoid mpn used controls results three methods statistically equivalent lta txb comparable methods roc curve auc lta cutoff threshold lta sensitivity specificity mea without added aspirin txb also comparable roc curve auc mea cutoff threshold patients falsely positive mea last mea lta comparable roc curve auc mea cutoff sensitivity specificity besides mea gave insight mechanism aspirin resistance turnover intrinsic conclusion mea rapid reliable compared reference methods clinical correlation risk rethrombosis definitively validate method best cutoff value elsevier ltd rights reserved
paper study singularity formation two nonlocal active scalar equations focusing hyperbolic flow scenario equations regarded simplified models fluid equations elsevier ltd rights reserved
background aimaccurate noninvasive biomarkers needed diagnose monitor inflammatory bowel disease ibd neutrophil gelatinase associated lipocalin ngal also known lipocalin expressed inflamed colonic epithelium neutrophilic granulocytes study explores properties biomarker feces plasma first time compares fecal ngal systematically existing fecal biomarker calprotectin methodsneutrophil gelatinase associated lipocalin measured feces patients ibd patients infectious enterocolitis patients irritable bowel syndrome healthy subjects using elisa results correlated calprotectin clinical score endoscopic score high sensitive reactive protein plasma patients ibd healthy controls analyzed ngal resultsfecal ngal levels median interquartile range significantly elevated active ulcerative colitis crohn disease compared patients inactive inactive irritable bowel syndrome healthy controls patients infectious enterocolitis significantly higher fecal ngal levels sensitivity specificity respectively distinguishing active ibd stability ngal stool excellent days room temperature plasma ngal significantly elevated compared conclusionsfecal ngal promising biomarker ibd existing biomarkers expressed mainly granulocytes ngal epithelial localization may give supplementary diagnostic information
paper presents method permits calculus dimensions component links quadrilateral mechanism ensures optimisation variation cinematic cycle connection forces joints mechanism functional constraints imposed connection forces obtained analytical form depending driving crank angle angular speed driving crank dimensions linear masses mass moments inertia component links value technological moment works rocker quadrilateral mechanism purpose simulation program developed using maple program powerful symbolic computation functions dimensions component links quadrilateral mechanism ensure optimum values connection forces joints mechanism determined using sequential quadratic programming approach operates optimisation function nlpsolve maple program calculus developed imposing two functional constraints total rotating angle rocker cinematic cycle value crank angle corresponding one two extreme positions rocker
new broadband reflective phaser based shunt stubs presented paper proposed phaser designed using shunt transmission line stubs inserted transmission line sections exhibits broad bandwidth corresponding design procedure presented implementation shunt stubs subsequently derived based kuroda identity mono port circuit network three numerical examples experimental validation finally provided illustrate proposed design approach
need situ soil moisture conservation arid semi arid regions due insufficient rainfall agriculture purpose combination implement integrated reservoir tillage system comprised single row chisel plow single row spike tooth harrow modified seeder spiked roller developed compared popular tillage practices viz minimum tillage conventional tillage arid mediterranean environment egypt different tillage practices conducted tillage depths forward speeds soil physical properties runoff soil loss water harvesting efficiency yield wheat evaluated different tillage practices caused significant differences soil physical properties increased soil infiltration producing rate higher obtained respectively lowest values runoff soil loss recorded whereas highest values recorded respectively conclusion enhanced infiltration rate increased water harvesting efficiency reduced runoff achieved highest yield wheat best tillage operating parameters appeared tillage depth speed elsevier rights reserved
previous studies show excellent particulate mixing fluidized bed reduce operating cost fluidization therefore paper investigates enhancement particulate mixing fluidized bed using novel inclined slotted swirling distributor reduce cost pumping power small size low pressure blower used study moreover geldart group bed materials different bed aspect ratios distributor designs viz perforated plate circular edged slots novel swirling distributors used novel distributor inclined slots found effective enhancing circulation rate swirling flow pattern bed materials clock wise direction obvious shallow bed two layer transversal lateral circulation motions observed deep bed concluded study excellent particulate mixing per rotated distributors made possible novel swirling type distributor without implementation electric motor mechanical rotation society powder technology japan published elsevier society powder technology japan rights reserved
new structure paralleling four leg shunt active power filters presented order compensate four wire electrical network supplying high power non linear single phase loads effective selectivity control fuzzy logic three dimensional space vector modulation svm introduced configuration sapfs maintain amplitude frequency output current inverter necessary determine numbers inverters service frequency commutation according power non linear single phase loads make operating stopping inverters without disturbing performance paralleling sapfs fuzzy logic controller flc three dimensional space vector modulation svm necessary robustness minimizing harmonics source currents reducing magnitude neutral current eliminating zero sequence current compensating reactive power four wire distribution network stabilizing bus voltage switching losses fixe switching frequency inverters also instantaneous real imaginary zero sequence powers theory alpha beta omicron axes presented generate reference currents injected paralleled four leg sapfs
rationale obesity related asthma associated higher disease burden normal weight asthma among hispanics adiposity metabolic dysregulation inflammation implicated pathogenesis obesity related asthma independent contributions poorly understood objective examine independent contributions body fat distribution metabolic abnormalities inflammation asthma symptoms pulmonary function among hispanics methods participants hispanic community health study study latinos doctor diagnosed asthma completed asthma symptom questionnaire performed valid spirometry included analysis multivariate analysis used examine independent association general adiposity assessed using body mass index truncal adiposity assessed waist circumference metabolic dysregulation presence insulin resistance low hdl inflammation high sensitivity reactive protein reported asthma symptoms pulmonary function measures fev fvc adjusting demographic clinical covariates results participants overweight obese fev fvc lower obese compared normal weight asthmatics analyses controlling metabolic adiposity factors high crp associated symptoms prevalence ratio lower fvc beta fev beta low hdl also associated lower fvc beta fev beta results similar men women conclusions findings suggest crp low hdl rather general truncal adiposity associated asthma burden among overweight obese hispanic adults elsevier ltd rights reserved
sexually violent predator statutes allow involuntary treatment individuals found pose threat public safety sex offender treatment programs rely cognitive interventions reduce risk recidivism purpose study examine whether individuals paraphilia diagnoses cognitive deficits compared general population whether individuals diagnosed pedophilia differed cognitive performance compared individuals diagnosed paraphilia otherwise specified nos nonconsent whether individuals paraphilia plus antisocial personality disorder aspd differed cognitive performance compared individuals paraphilia diagnosis sample consisted males age diagnosed pedophilia paraphilia nos nonconsent detained civilly committed forensic psychiatric hospital assessments included repeatable battery assessment neuropsychological status rbans wechsler abbreviated scale intelligence wasi wide range achievement test wrat individuals diagnosed pedophilia paraphilia nos nonconsent obtained lower scores matched controls based rbans immediate memory visuospatial constructional delayed memory indices total score comparison individuals paraphilia nos nonconsent pedophilia diagnosis lower scores rbans delayed memory individuals diagnosed paraphilia disorder combined aspd demonstrated trends toward lower scores paraphilia diagnosis treatment programs improve chance success assessment cognitive processes offer therapy style consistent cognitive abilities clients
landslides considered one natural hazards responsible casualties damage assets infrastructures many situations collection field data remote places difficult due inaccessibility landslide area paper examines landslide susceptibility bukit antarabangsa kuala lumpur ease geographical studies using image processing multivariate statistical tools reviewing digital images using remote sensing technique without physical survey considered different pixel resolutions report effectiveness using factor analysis principal component analysis linear discriminant analysis hybridization eight types databases heavy medium landslide created modeling works carried pixel resolutions results indicate optimal heavy medium found ideal landslide region performance different pixel resolutions compared using receiver operating characteristic roc curves average success found simple yet robust system holds great potential saving lives
entertainment technology video games popular social activity allow multiple players cooperatively engage screen challenges emerging research found people play together resulting teamwork beneficial impacts prosocial orientations gameplay especially players cooperative one another present study wanted expand scope beneficial interpersonal effects considering inter intrapersonal factors experimental study manipulated difficulty game easy hard behavior confederate teammate supportive unsupportive playing style found neither coplayer supportiveness game difficulty effect expectations teammate prosocial behavior one prosocial behavior toward teammate game operationalized willingness share small amounts money one teammate playing increased expectations prosocial behavior one teammate related one prosocial behaviors independent manipulations considering results propose alternative theoretical approaches understanding complex social interactions video games furthermore suggest explore types manipulations game difficulty cooperation video game players well alternative measures prosocial behavior
analog signal processing offers advantages power consumption viewpoint real time tinnitus detection method described paper detects tinnitus comparing ecog eeg signal energies different locations brain according tinnitus signature first proposed strategy selects appropriate ecog eeg bands per channel means band pass filters next extracted energies compared counterparts different healthy location tinnitus detected higher theta gamma energies associated lower alpha energy comparison corresponding signal energies healthy brain region present verify detector performance tinnitus cmos detector circuit designed implemented amis technology verified means simulations cadence using spectre final circuit operates supply consumes applicability detector verified means circuit simulations real neural waveforms able successfully detect tinnitus
purpose one concern regarding recent increase adolescent cigarette use possibility electronic cigarettes may used might otherwise used cigarettes dual use transition cigarette use alone may follow methods questionnaire data obtained grade students attending schools communities included southern california children health study evaluated cross sectional association cigarette use social environment family friends use approval cigarettes cigarettes susceptibility future cigarette use among never cigarette smokers using previously validated measures based reported absence definitive commitment smoke results among adolescents never used cigarettes past cigarette users current past day cigarette users indicated susceptibility cigarette use compared never cigarette users odds indicating susceptibility cigarette use two times higher current cigarette users compared never users odds ratio confidence interval social environment favorable cigarettes friends use positive attitudes toward use cigarettes also associated greater likelihood susceptibility cigarette use independent individual cigarette use conclusions cigarette use adolescence proee cigarette social environment may put adolescents risk future use cigarettes cigarettes may contribute subsequent cigarette use via nicotine addiction social normalization smoking behaviors society adolescent health medicine rights reserved
introduction traits obstructive sleep apnea syndrome osas impaired ventilatory control craniofacial abnormalities concomitant cardiovascular diseases associated modified endothelin gene edn endothelin receptor subtype ednra gene endothelin system regulates cardiovascular homeostasis edn interacts mainly ednra signal transduction study investigate associations ednra polymorphisms four frequent polymorphisms allele frequency osas severity methods three hundred ninety three patients older years caucasian origin osas ahi daytime sleepiness investigated cardiorespiratory polysomnography addition control subjects healthy sleep recruited nearly volunteers analysed ednra polymorphisms polymerase chain reaction restriction fragment length polymorphism real time pcr results carrier mutant allele significantly lower ahi comparing patients controls comparing osas severity groups without controls could detect significant correlations four investigated ednra polymorphisms data confirm bmi male gender significantly associated ahi allele frequencies similar discussion genetic investigation osa remains important control group relatively small investigated reasonable candidates ednra polymorphisms detected protective effect mutant allele needs confirmation gene based research osas use genome wide scan still consider endothelin system elsevier rights reserved
new hydraulic circuit introduced packaged singular component referred multifunctional flow control mfc valve usage conjunction self circulating hydraulic cylinders unlike conventional check valves whose directional flow restrictions permanent restriction flow direction mfc valve changed addition able act check valve either direction valve allow free flow flow fluid required total four positions proposed circuit mfc valve effectively represented two way four position valve furthermore design valve validated experimentation additionally aerospace application valve presented discussed herein
analytical treatment axisymmetric rigid punch indentation isotropic half space reinforced buried extensible thin film addressed aid appropriate displacement potential functions hankel transforms mathematical techniques mixed boundary value problem consideration reduced fredholm integral equation second kind interesting results problem including equivalent normal stiffness system contact stress distribution beneath rigid punch expressed terms solution obtained fredholm integral equation limiting cases corresponding inextensible extremely extensible thin films surface stiffened half space axisymmetric surface loading infinite embedment studied available results literature used verification purposes dimensionless plots provided show effects extensibility membrane system stiffness observed neglecting elastic behavior thin films utilizing simplified inextensible assumption modeling lead unrealistic predictions shown axisymmetric problems concerning elastic half spaces including surface effects equivalently modeled surface reinforced elastic medium taking surface effects account problem isotropic half space action surface patch load treated employing present approach
present work reports direct numerical simulations dns impinging round jet onto rotating heated disk confined rotor stator cavity geometrical characteristics system correspond experimental set developed pelle harmand heat transfer study rotor stator system air gap axial inflow applied thermal engineering aspect ratio cavity interdisk spacing rotor radius fixed corresponding narrow gap cavity axial reynolds number red based jet characteristics also fixed rotational reynolds number omega may vary preserve swirl parameter proportional omega dre centrifugal effects rotor periphery balanced centripetal flow along stator spiral patterns develop stator boundary layer corresponding sriii instability schouveiler gal chauve instabilities flow rotating stationary disk journal fluid mechanics enclosed cavity numerical results found agree particularly well experimental data terms distribution local nusselt number along rotor finally correlation averaged value proposed according swirl parameter elsevier inc rights reserved
jumping conclusions jtc distinguishes patients schizophrenia healthy psychiatric controls jtc typically assessed using beads task however faces number limitations interpretability reliability present study set validate new paradigm assess jtc box task adopted psychometric psychosis proneness approach divided large population sample participants scored high versus low scale tapping psychosis like experiences participants performed variant original beads task along new jtc task box task without time pressure box task requires participants infer two ball colors prevalent matrix boxes box task beads task significantly correlated medium effect size thus demonstrating criterion validity box task hypothesized participants scored high psychosis like experiences showed particularly strong jtc decreased decision threshold relative low scorers especially box task version time pressure contrast group differences beads tasks achieved trend wise significance mediation analyses showed fewer draws decisions predicted either lower decision threshold higher initial probability estimates dominant item study establishes criterion construct validity new jtc task advantages traditional beads task better comprehensibility usability multiple parallel versions created thus raising reliability
work presents computer aided design cad approach voltage reference circuits controlling main characteristics temperature coefficient power consumption mismatch caused manufacturing process transistor area output noise cad tool proposed methodology allow designer obtain accurate optimum initial circuit sizing thereby reducing large number computer runs usually required voltage reference circuit designs illustrative example carried cmos process verified post layout simulations whose results close agreement tool predictions shown paper reference circuit achieves output voltage temperature coefficient ppm temperature range maximum quiescent current power supply rejection ratio line regulation supply voltage chip occupies area
categories often unobservable diagnostic features example person lawyer one might expect well dressed knowledgeable law however without observing person courtroom one tell whether knowledgeable law might categorize well dressed person know whether possesses particular category feature two studies showed else equal individuals prefer group exemplars categories specify fewer unobserved unobservable features narrower latent scope broader latent scope experiment participants likely classify novel exemplars part social category narrower latent scope verbal task experiment demonstrated scope bias generalizes contexts category structure never explicitly specified elsevier inc rights reserved
soft magnetic composite smc materials possess many unique properties particularly suitable development novel structure electric motors various electric drive systems unique properties smc material include three dimensional magnetic thermal isotropy low eddy current loss prospect low cost mass production therefore application smc materials electrical appliance particularly electric motors attracted great interest research however smc materials also drawbacks low permeability high hysteresis loss low mechanical strength hence direct replacement electrical steels smc would necessarily lead satisfaction improvement motor performance fully explore application potential smc materials unique properties fully employed time effects drawbacks avoided minimized paper aims present key issues design smc electric motors based extensive research past two decades various researchers including authors paper key design issues discussed conclusions drawn future effort area
insulin like growth factor mannose phosphate igf receptor multifunctional single transmembrane glycoprotein recent studies advanced understanding structure ligand binding properties trafficking igf receptor receptor implicated variety important cellular processes including growth development clearance igf proteolytic activation enzymes growth factor precursors addition well known role delivery lysosomal enzymes igf receptor distributed widely central nervous system additional roles mediating neurotransmitter release memory enhancement consolidation possibly activating igf related intracellular signaling pathways recent studies suggest overexpression igf receptor may important role regulating levels transcripts proteins involved development alzheimer disease prevalent cause dementia affecting elderly population society reported igf receptor overexpression increase levels processing amyloid precursor protein leading generation beta amyloid peptide associated degeneration neurons subsequent development pathology given significance receptor mediating transport functioning lysosomal enzymes considered therapeutic delivery enzymes lysosomes treat lysosomal storage disorders notwithstanding results additional studies required validate fully characterize function igf receptor normal brain involvement various neurodegenerative disorders including also critical understand interaction igf receptor lysosomal enzymes neurodegenerative processes may shed light developing approaches detect prevent neurodegeneration dysfunction receptor endosomal lysosomal system
growing evidence supports idea aberrancies epigenetic processes contribute onset progression human immune mediated inflammatory diseases rheumatoid arthritis epigenetic regulators histone tail modifications play role chromatin accessibility transcriptional responses inflammatory stimuli among histone deacetylases hdacs regulate acetylation status histones nonhistone proteins essential immune responses broad spectrum hdac inhibitors well known anti inflammatory agents reduce disease severity animal models arthritis however selective hdac inhibitors remain poorly studied review describe emerging findings regarding aberrant acetyl code rheumatic disorders may help identify novel diagnostic prognostic clinical biomarkers also new targets epigenetic pharmacological applications
korea superconducting tokamak advanced research kstar central solenoid model coil csmc tested national fusion research center nfrc verify design manufacturing engineering ensure reliable operation csmc reached operation successfully also assessed loss csmc means sinusoidal wave offset well triangular pulse derived friction factor correlation csmc room temperature cryogenic temperature similar also investigated variation friction factor current charging kstar coil simulation code validated inlet outlet helium temperature mass flow rate pressure drop experimental results operation temperature margin coil kstar calculated revised kstar coil simulation coil
paper presents new method called transfer matrix method obtaining transfer functions among state variables linear time invariant lti system defined either block diagram corresponding signal flow graph procedures introduced paper obtaining transfer function require knowledge matrix operations easy explain remember advanced control engineers automate symbolic matrix operation using existing software mathematica
network servers applications commonly use static addresses communication ports making easy targets network reconnaissances attacks moving target defense mtd innovatory promising proactive defense technique paper develop novel mtd mechanism called random port address hopping rpah goal rpah hide network servers applications resist network reconnaissances attacks constantly changing addresses ports order enhance unpredictability rpah integrates source identity service identity temporal parameter hopping provide three hopping frequencies source hopping service hopping temporal hopping rpah provides high unpredictability maximum hopping diversities introducing port address demultiplexing mechanism provides convenient attack detection mechanism messages attackers using invalid inactive addresses ports conveniently detected denied experiments evaluation campus network planetlab show rpah effective resisting various network reconnaissance attack models network scanning worm propagation introducing acceptable operation overhead
induction motors fail due many reasons many rewound two times lifetimes generally assumed rewound motor efficient original motor precise estimation efficiency refurbished motor existing motor crucial industries energy savings auditing management full load partial load efficiency measured using dynamometer paper presents novel technique estimating refurbished induction motors full load partial load efficiencies load tests technique applied electric motor workshop eliminates need dynamometer procedure also eliminates need locked rotor test experimental field results testing eight induction motors presented degree accuracy shown comparing estimated efficiencies measured values provide necessary credits proposed technique error analysis conducted investigate level uncertainty testing three induction motors results uncertainty direct measurements load measurements using proposed technique presented
digital manufacturing essential meeting manufacturing requirements agility responsiveness paper reviews work carried authors manufacturing engineering centre mec advanced uses manufacturing information pertinent digital manufacturing work covers developments intelligent conceptual design advanced manufacturing information provision detailed design intelligent product manual generation rapid manufacturing business process modelling work presented paper within scope proms major project coordinated mec key features achievements date project described
adult cell leukemia lymphoma atl mature cell neoplasm strong association human lymphotropic virus type htlv infection infection endemic region north eastern iran highlighted janus kinase family proteins specially jak mutations pivotal role development many types hematological malignancies particular myeloproliferative neoplasms far underlying molecular mechanisms leading atl well understood therefore study hypothesized jak mutation may present samples patients atl case control study performed north eastern iran using polymerase chain reaction jak mutation performed dna samples atl patients htlv asymptomatic carriers control group results atl subjects control group compared using spss software case group patients male female respectively age range years one patients jak mutation mutation absent atl patients well htlv asymptomatic carriers results study demonstrated jak mutation common phenomenon atl however studies required investigate possible dysregulation jak signaling atl
african american men face highest rates prostate cancer yet consensus screening treatment making informed health care decisions difficult study aimed identify approaches empowering african american men proactive participants prostate cancer decision making using established community campus partnership employing elements community based participatory research methods community stakeholders interest knowledge health care two local african american communities recruited completed key informant interviews grounded theory coding identified common themes related prostate cancer knowledge beliefs attitudes responses common barriers gender roles fear fatalism identified barriers work treatment communities inadequate inaccurate prostate cancer information described key problem build community strengths participants said change must come inside communities imposed outside accomplish suggested reaching men women connecting men doctors trust making men cancer education part broader health education initiatives designed fun inexpensive family entertainment events churches bring community members speak experiences cancer study demonstrated success community engagement identify barriers also local strengths facilitators prostate cancer care two suburban rural african american communities building collaboratively community strengths may improve prostate cancer care specifically health care general
hepatitis virus hcv infection currently important cause chronic viral hepatitis world one frequent indications liver transplantation hcv uses different strategies evade innate adaptive immune response evasion plays key role determining viral persistence several hcv viral proteins described immune modulators review focus effect hcv nucleocapsid core protein function immune cells correlation findings observed hcv chronically infected patients effects immune cell function related extracellular intracellular hcv core localization considered review provides updated perspective mechanisms involved hcv evasion related one single hcv protein could become key tool development new antiviral strategies able control eradicate hcv infection
design tailor made gelators attracted tremendous level attention fabrication novel nanogels responsive characteristics exploiting gel properties nanocellulose abundance sustainability renewability reported fabrication fluorescent hydrogel based codoped graphene quantum dots gqds acting luminophore sensitizer incorporation gqds hydrogel resulted significant fluorescence intensity enhancement compared solutions conjunction recent efforts applicability optical responsive gels simple method based selectively sensing ability gqd hydrogel towards trichlorophenol tcp fluorescence enhancement disclosed validity strategy demonstrated analysis tcp red wine environmental water samples elsevier rights reserved
context awareness essential component systems developed areas like intelligent environments pervasive ubiquitous computing ambient intelligence emerging fields need computerized systems higher understanding situations provide services functionalities adapt accordingly literature shows researchers modify existing engineering methods order better fit needs context aware computing efforts typically disconnected generally focus solving specific development issues encourage creation holistic unified engineering process tailored demands systems purpose study state art development context aware systems focusing methodologies developing context aware systems analyzing reasons behind lack adoption features community wish use context aware system engineering challenges techniques applied common development stages context aware systems conceptualization elsevier inc rights reserved
objective diagnostic workup uveitis challenge due wide range diagnoses lack well codified diagnostic procedure aimed evaluate relevance diagnostic investigations etiological diagnosis uveitis methods retrospective cohort study patients referred etiological diagnosis uveitis uveitis related ophthalmological diseases occurring course previously diagnosed diseases included results three hundred patients included chest scan suggestive sarcoidosis features associated abnormal scan snowballs peripheral multifocal choroiditis pmc upon ocular examination blood lymphopenia uln bronchoscopy showed granuloma alveolar lymphocytosis suggestive sarcoidosis reported presence granulomaon bronchial biopsies always associated chest scan abnormalities whereas patients alveolar lymphocytosis normal scans features associated contributive bronchoscopy snowballs pmc ace uln abnormal chest scan salivary gland biopsy revealed granuloma patients cerebral mri abnormal patients mostly presented snowballs retinal vasculitis finally main causes uveitis latent tuberculosis sarcoidosis remained undetermined origin uveitis relapses observed differ patients identified diagnosis idiopathic uveitis conclusion identification factors associated abnormal investigations might improve optimal diagnostic workup adapted patient published elsevier
paper two new high input impedance voltage mode first order pass filters proposed first proposed circuit uses two dvccs active elements one floating capacitor one grounded resistor passive elements due grounded resistor phase filter electronically tunable second circuit requires two dvccs active elements one floating resistor one grounded capacitor passive elements utility validity proposed circuits analog signal processing applications verified pspice simulations using mosis cmos technology process parameters
article presents laboratory module developed undergraduate micro nano engineering laboratory courses mechanical engineering departments massachusetts institute technology king fand university petroleum minerals laboratory students fabricate superoleophobic membranes spray coating titania nanoparticles steel meshes characterize surfaces ability membrane retain oil use membranes separate oil water mixture laboratory module covers nanomaterials nanomanufacturing materials characterization understanding concepts surface tension hydrostatics oil water separation application laboratory experiments easy set based commercially available tools materials facilitate implementation module educational institutions significance oil water separation petroleum industry integration concepts fluid mechanics laboratory module help illustrate relevance nanotechnology mechanical materials engineering potential address future societal needs
objectives nuclear fusion power plant demo built iter experimental reactor usually understood lie somewhere iter first kind commercial plant hence demo issues related efficiency rami reliability availability maintainability inspectability among important drivers design cost electricity produced power plant strongly depend aspects framework eurofusion work package heating current drive within power plant physics development activities conceptual design neutral beam injector nbi demo fusion reactor developed consorzio rfx collaboration european research institutes order improve efficiency rami aspects several innovative solutions introduced comparison iter nbi mainly regarding beam source neutralizer vacuum pumping systems
background nail involvement psoriasis related psoriatic arthritis may represent predictor disease objectives analyze nail clipping clinically normal dystrophic nails patients cutaneous psoriasis psoriatic arthritis methods cross sectional multicenter study conducted august march patients divided four groups patients cutaneous psoriasis onychodystrophy patients cutaneous psoriasis clinically normal nails patients psoriatic arthritis onychodystrophy patients psoriatic arthritis clinically normal nails calculated napsi nail psoriasis severity index nail clinically noticeable change collection preparation nail clipping following microscopic parameters evaluated thickness nail plate subungual region presence absence parakeratosis serous lakes blood fungi results layers parakeratosis greater thickness subungual region patients cutaneous psoriasis onychodystrophy serous lakes also present group patients psoriatic arthritis normal nails microscopic parameters showed significant difference normal dystrophic nails patients psoriatic arthritis cutaneous psoriasis study limitations small sample size use medications conclusions nail clipping simple quick method assess nails patients nail psoriasis although demonstrate difference joint changes exclusively cutaneous psoriasis
exponential random graph model ergm well established statistical approach modelling social network data however monte carlo estimation ergm parameters computationally intensive procedure imposes severe limits size full networks fitted demonstrate use snowball sampling conditional estimation estimate ergm parameters large networks specific goal studying validity inference presence effects network closure attribute homophily estimate parameters snowball samples network parallel combine estimates meta analysis procedure assess accuracy method applying simulated networks known parameters also demonstrate application networks large nodes estimate social circuit advanced ergm specifications directly conclude approach offers reliable inference closure homophily elsevier rights reserved
paper presents original approach designing analog signal processing circuits based using functional core implementing two circuit functions signal gain theoretical null distortions signal squaring advantages increased modularity controllability reduced design costs represent immediate consequence double function realized proposed structures important circuit complexity concentrated implementing core structure circuit area power consumption per realized function strongly reduced using method overall error transconductance amplifier approximation error squaring circuit condition low voltage low power operation supply voltage medium current consumption implemented circuit function
hard estimate optical flow given realworld video sequence camera shake motion blur paper first investigate blur parameterisation video footage using near linear motion elements combine commercial pose sensor rgb camera order film video footage interest together camera motion illustrate additional camera motion trajectory channel embedded hybrid framework interleaving iterative blind deconvolution warping based optical flow scheme method yields improved accuracy within three state art baselines given proposed ground truth blurry sequences several realworld sequences filmed imaging system
paper presents design characterization fully differential intermediate frequency filter based operational transconductance amplifier ota order butterworth bandpass characteristic designed stage bicmos ota treated operational amplifier opamp together output resistance combination exhibits open loop voltage gain high gainbandwidth product gbp ghz stability achieved worst case phase margin degrees low bias current multiple feedback filter mfb elements target butterworth frequency response determined circuit analysis based ideal ota transfer function filter center frequency set mhz whereby measured bandwidth mhz achieved enable operation within time filter able settle steady state amplitude less filter fabricated ihp bicmos technology requires current supply including bias circuits
paper reviews circuitry differential stages dss based elements radiation hardened bipolar field effect analog gate array master chip agamc ojsc integral minsk city belarus suggests architectures amps oas realized base bjts jfets feature lies absence classical reference current source setting steady state behavior input transistors increases radiation stability parameters experimental circuit class oriented use sensor systems demanding application given
paper presents method solving tower deformation girder deflection multi tower suspension bridges equivalent model proposed simulate multi tower suspension bridge towers main cables treated series springs model used cases live load acting one spans simple explicit formulas used resolve deformation towers girders well increment horizontal cable force loaded span superposition principle used live loads acting one main span paper also presents finite element model fem multi span suspension bridge five towers six spans verify analytical formula results calculated fem show good agreement proposed method indicates proposed method effective preliminary analysis design multi tower suspension bridges
data multiphase schizoaffective disorder study nct used examine effects paliperidone palmitate monthly ppm subjects illness duration defined recent onset years since first psychiatric diagnosis chronic illness years symptom functioning scores measured open label ppm acute stabilization treatment phases improved subpopulations greater improvements recent onset chronic illness subjects relapse rates examined double blind placebo controlled phase higher placebo ppm hazard ratio confidence interval recent onset subpopulation chronic illness subpopulation growing evidence treatment schizophrenia schizoaffective disorder supports early intervention long acting antipsychotics
authors examined association maternal childhood abuse frequency providing social support mothers victim adult investigated mediating effects internal working models self esteem positive relations others maladaptive coping using data national survey midlife development united states analyzed sample adult children using structural equation modeling approach results showed maternal childhood abuse associated providing less frequent emotional support mothers although authors find significant mediating effects internal working models maladaptive coping association child abuse intergenerational support giving findings suggest implications theory practice policy address specific concerns possible challenges adults history childhood abuse may experience relationship mothers
variations examination timetabling problem investigated research community two decades common characteristic problems fact definitions datasets used originate actual educational institutions particularly universities including specific examination criteria students involved although much achieved published state art problem modelling optimisation lack attention focussed students involved process work presents utilises results extensive survey seeking student preferences regard individual examination timetables aim producing solutions satisfy preferences still also satisfying existing benchmark considerations study reveals one main concerns relates fairness within student cohort student considers fairness respect examination timetables immediate peers highly important considerations providing equitable distribution preparation time student cohort examinations majority used form measure fairness order satisfy requirement propose extension state art examination timetabling problem models widely used scientific literature fairness introduced new objective addition standard objectives creating multi objective problem several real world examination data models extended benchmarks used experimentation determine effectiveness multi stage multi objective approach based weighted tchebyceff scalarisation improving fairness along objectives results show proposed model methods allow production high quality timetable solutions also providing trade standard soft constraints desired fairness student elsevier rights reserved
purpose study purpose examine demographic healthcare contextual correlates smoking among sexual minority women smw methods data chicago health life experiences women study results rate current smoking former nonsmokers respectively history ever smoking associated lower educational levels partner smokes heavy drinking illicit drug use bisexual identity statistically significant correlates former versus current smoker included higher education nonsmoking partner newest recruited cohort less illicit drug use past year quit attempt among current smokers associated higher levels illicit drug use longer time first cigarette original cohort conclusion study results highlight key correlates smoking behaviors among smw make important contribution literature smoking disparities additional research needed inform smoking cessation prevention control efforts reduce known persistent smoking disparities among smw
positive youth development thought essential prevention adolescent risk behavior promotion thriving meta analysis examined effects positive youth development interventions promoting positive outcomes reducing risk behavior ten databases grey literature scanned using predefined search strategy included studies focused young people aged years implemented positive youth development intervention outside school hours utilized randomized controlled design twenty four studies involving participants met inclusion criteria included analysis impact interventions outcomes including behavioral problems sexual risk behavior academic achievement prosocial behavior psychological adjustment assessed positive youth development interventions small significant effect academic achievement psychological adjustment significant effects found sexual risk behaviors problem behavior positive social behaviors intervention effects independent program characteristics participant age low risk young people derived benefit positive youth development interventions high risk youth studies examined several methodological flaws weakened ability draw conclusions substantial progress made theoretical understanding youth development past two decades progress needs matched intervention literature use high quality evaluation research positive youth development programs
background purpose aim evaluate relationship distal hyperintense vessel sign hvs early neurological deterioration end acute ischaemic stroke large vessel steno occlusion methods acute ischaemic stroke patients symptomatic severe steno occlusion middle cerebral artery internal carotid artery recruited within symptom onset stroke outcomes evaluated using national institutes health stroke scale nihss score time admission days end defined increment motor nihss score total nihss score distal hvs defined hyperintensity fluid attenuated inversion recovery image located distal sylvian fissure extent distal hvs divided absent subtle prominent results amongst total participants end found patients end associated age atrial fibrillation initial nihss score initial infarct volume severe leukoaraiosis hemorrhagic infarction distal hvs multivariate analysis distal hvs remained independent predictor end adjusted odds ratio aor confidence interval initial infarct volume aor severe leukoaraiosis aor also associated end independently distal hvs analysis burden distal hvs stroke outcomes prominent distal hvs associated stroke severity infarct volume dose response manner conclusions distal hvs associated end acute ischaemic stroke patients large vessel steno occlusion
paper develops unified analysis stagnation flow heat mass transport considering semi infinite domains finite gaps without rotation stagnation surface important objective derive nusselt sherwood number correlations represent heat mass transport stagnation surface approach based computationally solving governing conservation equations similarity form boundary value problem formulation considers ideal gases incompressible fluids correlated results depend fluid properties terms prandtl schmidt damkohler numbers heterogeneous chemistry stagnation surface represented single first order reaction composite reynolds number represents combination stagnation flows without stagnation surface rotation published elsevier ltd
concept homogeneous integrity constraints database systems introduced metric space state database schemes homogeneous integrity constraints established shown many common integrity constraints used practice satisfy condition homogeneity integrity constraints constraints include key referential joint many many integrity constraints etc proposed constructs allow one design metric spaces state database schemes enable study integrity constraints databases based methods concepts continuous mathematics
study ankylosing spondylitis made significant progress last decade genome wide association studies identified substantiated role susceptibility genes outside major histocompatibility complex locus however human leukocyte antigen hla suggested important pathogenesis contributing similar heritability current review present classical non classical forms hla well pathogenic roles discuss hypotheses regarding potential pathogenesis addition association pathogenic role hla inflammatory indexes including interleukin axis investigated provide novel insights pathogenesis aim present review provide update current research pathogenesis provide comprehensive description pathogenic role hla
study earthworms eisenia fetida fetida exposed soil artificially contaminated individual hexabromocyclododecane hbcd diastereoisomers alpha beta gamma hbcds investigate distribution isomerization enantiomer selectivity hbcds tissue subcellular levels tissue level concentrations hbcds followed order gut bodyfluid body wall suggested earthworms accumulated hbcds mainly via ingesting soil particles subcellular level concentrations hbcds extracellular fraction consisting granules tissue fragment cell membrane intact cells fraction higher intracellular fractions consisting microsomal cytosol fraction confirmed passive diffusion distribution hbcds intracellular compartment distribution proportions hbcds varied among different tissue subcellular fractions changed time within days variable distributions hbcds different fractions result comprehensive effects dynamics thermodynamics processes beta gamma hbcds isomerized alpha hbcd tissue subcellular fractions except fraction isomerization ratios varied lot seemed related hbcds residence time selective enrichment alpha beta gamma hbcds found fractions consistent whole earthworm besides extents enantio selectivity change significantly among different tissue subcellular fractions
present ontop open source ontology based data access obda system allows querying relational data sources conceptual representation domain interest provided terms ontology data sources mapped key features ontop solid theoretical foundations virtual approach obda avoids materializing triples implemented query rewriting technique extensive optimizations exploiting elements obda architecture compliance relevant recommendations including sparql queries rrml mappings owlql rdfs ontologies support major relational databases
aim describe treatment pattern complications direct medical costs associated ankylosing spondylitis chinese urban patients methods china health insurance research association chira urban insurance claims database used identify patients identified patients stratified treatments comparisons well established related complications direct medical costs conventional regression analyses adjusted collected patient baseline characteristics confirm impact treatments complications direct medical costs results identified patients received non steroidal anti inflammatory drugs nsaid received immunosuppressant received nsaid plus immunosuppressant received biologic agents received medications without indication biologic group associated lowest proportion related complications confirmed multiple logistic regression analysis odds ratio biologic group also associated highest direct medical costs median rmb confirmed multiple generalized linear model coefficient conclusions biologics commonly used chinese patients likely due high cost future studies needed confirm potential long term clinical benefits associated biologic treatment
standard derivation kirchhoff voltage law based assumption first law thermodynamics sum products applied emf corresponding currents heat dissipation satisfied within loop contrast start fact first law thermodynamics applies globally electric circuit whole shown kirchhoff voltage law may derived extremum system entropy production constrained first law applied globally extremum maximum thus stationary distribution currents linear electric circuit governed principle maximum entropy production
paper give explicit construction basis matrices visual cryptography scheme integers balanced vcs every set participants equal cardinality relative contrast vcs constructed paper balanced general also obtain formula pixel expansion relative contrast also prove construction gives optimal contrast minimum pixel expansion
investigation paper dimensional nonlinear schrodinger equation heisenberg ferromagnetic spin chain via symbolic computation hirota method bilinear forms dark one two three soliton solutions derived propagation interaction dark solitons illustrated graphically amplitude shape dark one soliton keep invariant propagation imply transport energy stable dimensional heisenberg ferromagnetic spin chain asymptotic analysis elastic inelastic interactions dark two solitons discussed elastic interaction oblique head overtaking interactions dark two solitons displayed amplitudes shapes remain unchanged interaction except certain phase shifts however area inelastic interaction amplitudes dark two solitons vanish interaction elastic interaction among dark three solitons oblique overtaking interaction among dark two parallel solitons single one presented whose characteristics similar dark two solitons inelastic elastic interaction investigated well linear stability analysis used analyze modulation instability prove dark solitons stable elsevier ltd rights reserved
background although association menopause cardiovascular disease cvd risk studied extensively simultaneous role chronological aging herein remains underexposed study aims disentangle relationships menopausal status chronological aging cvd risk factors largest study population date methods cross sectional study cvd risk factors compared women different menopausal status within yearly age strata study population comprised female participants baseline visit population based lifelines cohort study total women aged years included women considered premenopausal perimenopausal naturally postmenopausal surgically postmenopausal results compared postmenopausal women aged years average total cholesterol low density lipoprotein cholesterol ldl mmol higher respectively postmenopausal women aged systolic diastolic blood pressure levels mmhg higher respectively ages years adjustment confounders naturally postmenopausal women mmol higher mmol higher ldl levels compared premenopausal women age range systolic blood pressure levels mmhg lower naturally post compared premenopausal women ages years body mass index levels higher women surgical menopause compared women ages years aforementioned results statistically significant conclusions chronological age menopausal status independently associated cvd risk factors based comparatively smaller observed differences associated menopausal status chronological aging significance unfavorable lipid profile later reproductive stage may less obvious previously thought
double digested radseq ddradseq ngs methodology generates reads thousands loci targeted restriction enzyme cut sites across multiple individuals statistically sound economically optimal ddradseq experiment preliminary design stage needs consider issues related selection enzymes particular features genome focal species possible modifications library construction protocol coverage needed minimize missing data potential sources error may impact upon coverage present ddradseqtools software package help ddradseq experimental design generation silico double digested fragments construction modified ddradseq libraries using adapters either one two indexes degenerate base regions dbrs quantify pcr duplicates iii initial steps bioinformatics preprocessing reads ddradseqtools generates single end paired end reads may bear snps indels effect allele dropout pcr duplicates coverage also simulated resulting output files submitted pipelines alignment variant calling allow fine tuning parameters software validated specific tests correct operability program correspondence silico settings parameters ddradseq vitro experiments assessed provide guidelines reliable performance software ddradseqtools cost efficient terms execution time run computers standard cpu ram configuration
previously reported perlecan heparan sulfate proteoglycan hspg expressed synovium cartilage synovial junction required osteophyte formation knee osteoarthritis examine mechanism underlying process examined role perlecan proliferation differentiation synovial mesenchymal cells smcs using recently established mouse synovial cell culture method primary smcs isolated hspg hspg cola hspg mice perlecan knockout rescued perinatal lethality lack perlecan chondrogenic osteogenic adipogenic potentials examined hspg smcs compared control smcs prepared wild type hspg hspg cola hspg littermates culture condition permitting proliferation control hspg smcs showed similar rates proliferation expression cell surface markers however micromass cultures cartilage matrix production sox cola mrna levels significantly reduced hspg smcs compared control smcs reduced level sox mrna restored supplementation exogenous perlecan protein difference osteogenic differentiation control hspg smcs measured levels runx cola mrna adipogenic induction ppar mrna levels significantly reduced hspg smcs compared control smcs reduction ppar mrna levels hspg smcs restored supplementation perlecan perlecan required chondrogenic adipogenic differentiation smcs via regulation sox ppar gene expression osteogenic differentiation via runx orthopaedic research society
backgroundincreasing evidence supports mentalization deficits may role genesis young age depression however studies examined issue clinical populations methodsoutpatients aged suffering various psychiatric disorders assessed using mentalization questionnaire mzq beck depression inventory bdi childhood trauma questionnaire ctq using data age matched healthy students comparison relationship ctq mzq bdi scores examined cross sectional level including mediation analyses longitudinally subsample underwent psychotherapy intervention resultsof subjects mentalization levels standard deviation comparison subjects whole sample levels mentalization inversely associated bdi ctq scores moreover mzq scores mediated large part effect childhood trauma depression total effect direct effect indirect effect effect almost entirely explained affect regulation subscale patients evaluated four sessions decrease bdi scores correlated increase mzq scores conclusionsin juvenile clinical sample deficits mentalization abilities associated severity depression explained part depressogenic effects childhood trauma
prevalence developmentally vulnerable children living parental mental illness well documented however due stigmatised attitudes prejudice children may hidden identified requiring additional assistance early childhood settings aim present study explore experiences workforce needs centre based child care staff working families living parental mental illness eight staff four child care workers four child care directors worked centre based child care interviewed using semi structured interviews data analysed using interpretative phenomenology analysis framework findings present study highlighted four central themes child development issues tension around referral worker anxiety inadequate knowledge training parental mental illness sensitivity working families participants knowingly prioritized importance working families daily work described feeling stressed anxious discussing referral options parents often worried making things worse child parent present study contributed knowledge regard important segment early childhood workforce information inform development tailored professional training resources provide information referral procedures support programs families published elsevier ltd
well established certain categories objects processed efficiently others specific tasks phenomenon known category specificity perceptual conceptual processing last two decades also several reports gender differences category specificity present experiments test proposition gender differences evolutionary origin would expect emerge even population tested comprises young individuals raised gender equality oriented society contrary expectation find evidence gender differences category specificity relatively large sample drawn population despite fact tasks applied object decision superordinate categorization gave rise reliable category effects suggest plausible account discrepancy previous reports gender differences may reflected differences familiarity originating socially based gender roles elsevier ltd rights reserved
one efficient ways connect resistive sensor array using columns rows structure main problem implementation crosstalk appearing due non idealities readout circuits crosstalk causes measurement errors restrict usable range array size resistive sensors values paper analyses way factors affect accuracy setting new approach eliminate reduce influence based additional operational amplifier calibration resistors without significant increase readout time first method involves introducing additional column order eliminate combined effect output resistance buffers row selection offset voltages bias current operational amplifier second method row resistors added order reduce effect finite gains theoretical analysis performed validated simulation results show improvement accuracy compared proposals literature possible
purpose purpose study identify specific metabolic brain pattern characteristic parkinson disease parkinson disease related pattern pdrp using network analysis fluorodeoxyglucose positron emission tomography fdg pet brain images cohort slovenian patients methodstwenty patients age years movement disorder society unified parkinson disease motor rating scale mds updrs iii disease duration years age matched normal controls ncs underwent fdg pet brain imaging automatic voxel based scaled subprofile model principal component analysis ssm pca applied scans pdrp slovenia identification results pattern characterized relative hypermetabolism pallidum putamen thalamus brain stem cerebellum associated hypometabolism sensorimotor cortex posterior parietal occipital frontal cortices expression pdrp slovenia discriminated patients ncs correlated positively patients clinical score mds updrs iii additionally topography agrees well original pdrp identified american cohort patients validated pdrp slovenia expression additional fdg pet scans patients ncs patients atypical parkinsonism confirmed expression pdrp slovenia manifests good diagnostic accuracy specificity sensitivity optimal pattern expression cutoff discrimination patients ncs expressed conclusion pdrp slovenia proves robust reproducible functional imaging biomarker independent patient population accurately differentiates patients ncs correlates well clinical measure progression
university studies changed spain last five years order adequate european space higher education changes spanish law fixes skills abilities must acquire graduates engineering competences applications industrial field among found corresponding manufacturing engineering work integrated lab practical class performed including different stages manufacturing process product process design final product practical class developed six sessions experience shown interest students contents subject relationship theoretical concepts
objective main purpose study investigate factors affecting dental care utilization among nursing home residents jordan methods total subjects mean age years males females taken among nursing home residents across jordan recruited composed convenience sample study mini mental state examination mmse geriatric depression scale gds tinetti assessment battery gait balance tab disability arm shoulder hand test dash administered oral health status assessed subjects examined expected correlates dental care utilization among nursing home residents results response rate one third residents suffered total edentulism remaining dentate residents exhibited periodontal disease dentate sample residents bleeding upon probing diagnosed tooth mobility presence dental calculus diagnosed root caries denture wearers reported soreness dentures denture wearers reported poor quality dentures mmse score suffering tooth sensitivity diabetes mellitus identified indicators utilization dental care services among study population conclusion regular oral care assessments rehabilitation services considered limited nursing home residents jordan based upon findings future interventions address oral health among nursing home residents jordan
children living agricultural communities greater risk pesticides due para occupational pathways goal study assess impact exposure organophosphorus pesticides neurobehavioral performance school aged latino children time two exposure measures used estimate children pesticide exposure parent occupation agricultural nonagricultural organophosphate residues home carpet dust samples school aged children completed battery neurobehavioral tests two times approximately one year apart associations exposure measures neurobehavioral performance examined pesticide residues detected dust samples agricultural non agricultural homes however pesticides detected frequently higher concentrations agricultural homes compared non agricultural homes although differences found agricultural non agricultural children visits deficits learning first visit second visit less improvement found agricultural children relative non agricultural children differences significant divided attention purdue pegboard tests findings consistent previous research showing deficits motor function summary measure organophosphate residues associated neurobehavioral performance results study indicate children agricultural communities increased risk pesticides result parent working agricultural findings suggest organophosphate exposure may associated deficits learning neurobehavioral performance particularly tests motor function spite regulatory phasing organophosphates still see elevated levels higher detection rates several organophosphates agricultural households non agricultural households albeit lower levels prior studies elsevier inc rights reserved
anthropomorphism impressions animals commonplace generalization humans animals one example broader tendency generalize adaptively significant categories judging specific exemplars although anthropomorphism may lead unlikely incorrect judgments fostered accurate sex differentiation macaque faces due appropriate generalization sexually dimorphic cues distinguish human male female faces macaques predicted koreans performed better caucasians sex differentiating macaque faces difference mediated koreans greater use sexually dimorphic eye height cues results extend disambiguate evidence east asian superiority sex differentiating human faces whereas race advantage might explain previous present findings explained east asians keener sensitivity sexually dimorphic cues perhaps owing greater subtlety cues east asian faces implications sensitivity cultural differences person perception discussed elsevier inc rights reserved
paper discusses application gamification techniques ambient intelligence context three layer framework ambient intelligence based concept interconnection among actors involved intelligent environment first delineated mechanisms user driven creation modification environment behavior advocated user layer purpose event condition action rules promoted literature position paper would like suggest user interfaces rule construction must integrated proper techniques user engagement motivation proposed gamification theory
autism related disorders increasingly prevalent behavioral syndromes impaired verbal nonverbal communication socialization owing neurodevelopmental abnormalities recent estimate prevalence autistic disorders global scale etiology autism multifactorial multidimensional makes therapeutic intervention even harder heterogeneity genetic factors oxidative stress autoimmune mechanism epigenetic mechanisms complicate nature pathogenesis disease nutraceutical approach treat disease promising strategy especially areas attractive others review critically analyzes roles vitamins cofactors dietary modifications gut abnormalities probiotics prebiotics phytochemicals environmental factors order determine state evidence nutraceutical based autism management practices article presents systematic review randomized placebocontrolled trials examine evidence supports use autism nutraceuticals results discussed light relevant evidence generated clinical exploratory studies king saud university production hosting elsevier rights reserved
study aimed explore synthesize expert clinical knowledge defining managing unhealthy exercise adolescents delphi methodology used clinicians considered experts treatment adolescents recruited internationally form panel first round questionnaires comprised five open ended questions regarding defining assessing treating unhealthy exercise adolescents statements derived data using content analysis included likert based items two subsequent rounds panellists required rate level agreement item respondents completed three rounds questionnaires consensus achieved items included second third round questionnaires although consensus achieved compulsive exercise preferred term panel referring unhealthy exercise adolescents panel clearly delineated features unhealthy healthy exercise endorsed number items considered important assess evaluating exercise clinical population variety treatment approaches strategies reached consensus notably medically stable progressing toward recovery panel recommended initial exercise restriction practices reintroducing healthy exercise behaviors rather exercise cessation practices current findings serve preliminary treatment guidelines unified approach labeling defining unhealthy exercise eating disorder literature clinical settings required achieve progress
historically electrical safety managed within construction project project introduced electrical current site rather design phase project management may discussed electrical safety design phase without including construction management key issues electrical safety may overlooked cause safety concerns actual building process construction projects include electrical safety prevention design core design principle electrical safety begin upstream design process follow entire lifecycle project paper proposes including construction management electrical safety throughout entire project also cover three broad areas concern management temporary permanent electrical power phases construction electrical safety moving energized equipment energized equipment safety commissioning equipment relevant safe guards control construction transfers control commissioning operations areas planned designed decided construction begins involvement contractor planning design phases many incidents safety concerns avoided also time money saved planning equipment delivery placement energizing
experimental study shows results analysis performance stand alone renewable energy system greenhouse heating winter day systems consist photovoltaic panels connected electrolyzer daylight hours produce hydrogen electrolysis store pressure tank night thanks fuel cell hydrogen converted electricity order feed ground source geothermal heat pump heat tunnel greenhouse procedure estimating hourly solar radiation hydrogen production consumption short term energy storage partly cloudy day also given solar energy usability concept capacity energy storage systems thermal energy load govern effective energy management system performance analysis necessary determine actual total efficiency integrated photovoltaic geothermal hydrogen renewable energy systems contribution load overall system efficiency obtained starting amount solar energy available daylight hours used thermal energy night elsevier ltd rights reserved
pharmacologic interventions human immunodeficiency virus hiv wasting studied since results interventions difficult compare studies used different hiv wasting definitions assessed various patient outcomes thus performed systematic review current literature identify studies evaluated pharmacologic management hiv wasting compare contrast treatment options provide comprehensive review treatment options describe definition hiv wasting used study outcomes assessed whether antiretroviral therapy used hiv wasting treatment literature searches pubmed medline google scholar databases performed review bibliographies retrieved articles performed identify additional references english language articles pertaining humans hiv infected individuals evaluated thirty six studies identified assessed pharmacologic interventions treat hiv wasting appetite stimulants megestrol acetate shown increase total body weight tbw body mass index hiv infected patients wasting studies evaluating dronabinol showed conflicting data tbw increases drug may minimal benefit body composition compared appetite stimulants testosterone shown effective hiv wasting suffer hypogonadism recombinant human growth hormone evaluated hiv wasting shown promising results tbw lean body mass increases thalidomide studied however use limited due toxicities although megestrol acetate dronabinol approved food drug administration fda treatment hiv wasting important recognize comorbidities depression hypogonadism may contribute patient appetite weight loss patient diagnosed hypogonadism hiv wasting testosterone would good therapeutic option although mirtazapine fda approved management hiv wasting shown promote weight gain treating depression symptoms mirtazapine may promising pharmacologic option management hiv wasting depression research needed
background healthy love brief highly interactive single session group level hiv prevention intervention designed african american women effective reducing sex risk behaviors increasing condom use hiv testing among participants centers disease control prevention contract developed user friendly intervention package would allow organizations adopt implement healthy love fidelity method training implementation materials developed support original research protocols piloted revised conduct field testing case study agencies csas three csas selected deliver intervention month period test utility intervention materials feasibility implementation results csas able successfully deliver sessions total women ranging years age successes challenges encountered training preimplementation activities intervention delivery described discussion lessons learned training technical assistance process monitoring evaluation informed final package revisions research practice recommendations shared guidance future implementations healthy love research practice process used model approach developing comprehensive intervention package support adoption healthy love organizations
although construction industry major component economy suffering declining productivity decades human element project managers pms particular key solving persisting problems measurement overall performance important identify training needs enables executives better match competent pms appropriate projects paper provides construction industry generic mathematical formulation reliably weigh different competencies developed data driven mathematical model reflects relative importance industry practitioners place different competencies distinguishing exceptional pms average ones developed model applied data set assessments filled supervisors supervisor selected rated exceptional average results presented paper suggest pms focus developing cognitive side rather settling possessing adequate knowledge experience managerial skills leadership capabilities also quantitative results illustrate business financial acumens disciplinary understanding phases construction projects interrelationships continuous monitoring similar construction projects consistent awareness available information technologies among distinguishing competencies exceptional average pms results assist construction industry directing efforts toward accurately identified leverage development areas pinpointing actual training educational needs additionally paper compares results developed data driven mathematical model existing expert evaluation presenting key step revealing turn reducing experts subjectivity
honeypots networked computer systems specially designed crafted mimic normal operations systems capturing storing information interactions world outside crucial technology study cyber threats attacks propagate occur networks among high interaction honeypots considered efficient attacker whether automated perceives realistic interactions target machine case automated attacks propagated malware currently available honeypots alone specialized enough allow analysis behaviors effects target system research presented paper shows high interaction honeypots enhanced powering specific features improve reverse engineering activities needed effectively analyze captured malicious entities
electrokinetic properties polythiophene graft chitosan copolymer investigated means zeta zeta potential measurements function electrolytes surfactants temperature aqueous medium potential pure observed enhance grating polycationic concomitantly isoelectric point pure shifted zeta potential dispersion also shifted positive regions increasing valency electrolytes concentrations cationic surfactant cetyltrimethylammonium bromide potential determined indicated colloidal stability silicone oil medium electrorheological viscoelastic measurements revealed system elasto viscous behavior applied electric field strengths yield stress fluid determined function electric field strength power law form tau obey conduction model creep creep recovery tests revealed reversible non linear viscoelastic deformations conditions elsevier rights reserved
past decades researchers documented positive associations direct child maltreatment exposure interpersonal violence including intimate partner violence community violence school violence media violence children externalizing behavior problems however current family violence literature largely ignores effects child abuse children family handful studies focused exposure child abuse documented behavioral effects siblings studies lend support broadening scholarship focused type family violence article presents empirical research theories focus relationships child physical abuse exposure intimate partner violence children externalizing behavior problems using literature foundation argument made need focus children exposure child physical abuse article presents information studies focused children exposed physical abuse sibling offers theoretical frameworks including social learning theory psychological proximity foundation future research article concludes discussion services may necessary children exposed physical abuse sibling including services focused safety mental health elsevier ltd rights reserved
high valent iii complexes attracted much attention catalysts many reactions nevertheless iii catalysts suffer instability oxidized metal complexes preparation use herein demonstrated iii catalysts stabilized reduction metallic modifying supported ionic liquid phase stabilized iii catalyst cucl found reduced could oxidized situ species cucl reaction stabilized electron transfer active species evaluated acetylene hydrochlorination reaction catalyst displayed excellent specific activity turnover frequency tof high selectivity fot product vinyl chloride vcm furthermore catalyst demonstrated stable catalytic performance negligible loss conversion typical industrial reaction conditions acetylene hydrochlorination therefore findings work provide efficient approach designing stable high valent metals long term operation also pave way application catalyst industrial vcm production elsevier rights reserved
detection fungal elements characterization patient specimens provides fundamental information histological sections fungi frequently seen skin mucosal surfaces mycotic thrombi emboli occlude arteries veins surgical specimen immunocompromised patients tissues obtained autopsies microbial culture continues central method diagnosing fungal infection complemented histomorphology using specific stains capable identifying previously unsuspected fungal infections evaluating tissue invasion stains employ oxidizing reagents create aldehyde binding sites polysaccharides glycol groups fungal cell walls either schiff reagent silver ions gomori methenamine silver gms periodic acid schiff pas modifications commonly used tissue sections cytology specimens
aiming poor optimization effect search difficulty feasible solution problems existing optimization methods deriving reservoir operation rule curves genetic algorithms based dynamic variable sampling space dvss proposed establish common multi objective optimization model study modeling theory method comprehensively introduced aspects operation rule curve generalization simulation model objective function algorithm design siping reservoir china chosen case study analyzing computational efficiency optimization effect algorithms results validated good effectiveness feasibility model algorithms good application value
energy efficient designs receiving increasing attention various fields engineering heating ventilation air conditioning hvac control system designs involve improved energy usage acceptable relaxation thermal comfort paper real time data building hvac system provided buildinglab considered resistor capacitor framework representing thermal dynamics building estimated using particle swarm optimization pso algorithm objective costs thermal comfort deviation room temperature required temperature energy measure explicit mpc design building model executed based state space representation supply water temperature input room temperature output dynamics controllers subjected servo tracking external disturbance ambient temperature provided real time data closed loop control control strategies ported picmx series microcontroller platform building model implemented matlab hardware loop hil testing strategies executed usb port results indicate compared traditional proportional integral controllers explicit mpc improve energy efficiency thermal comfort significantly elsevier inc rights reserved
introduction risk factors infection protective effect vaccines immune thrombocytopenia itp patients era rituximab therapy unknown objectives assess risk factors serious non serious infections respectively sis nsis non splenectomized adults treated persistent chronic primary itp including effect pneumococcal influenza vaccines patients methods population faith cohort cohort incident newly diagnosed primary itp adults treated months france built national health insurance database sniiram sis hospitalizations infection primary diagnosis code nsis identified using hospital antibiotic dispensing cox models performed results incidence rates patientyears confidence interval sis lower respiratory tract cases patient years nsis multivariate analyses increasing age chronic pulmonary disease associated nsi occurrence hazard ratios hrs corticosteroids rituximab respectively sis nsis pneumococcal vaccine showed protective effect sis nsis respectively influenza vaccine respectively conclusions chronic pulmonary disease corticosteroids rituximab main risk factors infections whereas pneumococcal influenza vaccines protective sis nsis
forensic medical evaluation rates child abuse victims texas low relative national rates exploring reasons researchers collected quantitative qualitative interview focus group data multidisciplinary child abuse response team members across state paper presents results secondary analysis health care providers interview focus group transcripts looking specifically experiences conducting forensic evaluations thoughts struggles ethical issues analysis conducted critical realist perspective using content discourse analysis theme ambivalence identified explored three discursive themes identified ambivalence legal role health care role unintended outcomes evaluations extra discursive elements related physical body resource distribution funding policy examined interaction discursive patterns implications findings include addressing issues current approach responding child abuse uniting around common definitions abuse refining parameters fme helpful shoring material resources abuse response infrastructure considering modification providers roles activities relative forensic work deploying providers prevention activities versus reactive activities elsevier ltd rights reserved
background although recent studies suggest eczema early childhood important development food allergy importance timing eczema onset fully clarified objective study aim identify association timing eczema onset development food allergy prospective birth cohort study methods data obtained tokyo children health illness development child study hospital based birth cohort study currently progress japan total children born recruited women outcome data children collected questionnaires completed months years age association timing eczema onset development food allergy estimated logistic regression analyses analysis performed using spss software two sided significance level results eczema first year life significant risk factor multivariate analysis aor age month stratum infants onset eczema within first months birth highest risk food allergy years age aor conclusion infants early eczema onset especially within first months birth found increased risk developing food allergy years age findings may contribute better understanding timing eczema onset potentially modifiable risk factor defining may need guard food allergy japanese society investigative dermatology published elsevier ireland ltd rights reserved
reversal dabigatran associated major bleeding achieved antidote idarucizumab evaluated activated prothrombin complex concentrate apcc alternative purpose patients treated dabigatran suffering major bleed treated per existing hospital protocol apcc subsequently recruited day follow effectiveness evaluated treating physician using assessment guide safety outcomes arterial venous thromboembolism death comparison also made historic cases dabigatran associated major bleeds treated supportive care matching type bleed age sex aimed evaluable cases study prematurely discontinued cases due availability approved antidote effectiveness apcc assessed good moderate poor none thromboembolic events one death secondary adjudication effectiveness using criteria adjudicators previously done historic cases outcome graded current cases versus historic cases good moderate poor versus versus versus respectively although supportive care sufficient tomanagemany patients dabigatran associated bleeding apcc might provide additional benefit control life threatening bleeding selected cases appear cause excess thromboembolic events elsevier ltd rights reserved
caffeic acid plant polyphenol acts antioxidant various pharmacological effects dna one major cellular targets therapeutic molecules thus studying interaction small molecules dna great importance current article studied mode binding calf thymus dna dna using series biophysical techniques formation complex dna ascertained analyzing vis absorbance fluorescence emission spectra upon successive addition dna binding constants dna obtained using multiple experiments order consistent known groove binders analysis thermodynamic parameters suggest hydrogen bonding van der waal forces played major role binding process competitive displacement studies confirmed binds minor groove dna observations validated quenching experiment dna melting studies viscosity measurements silico molecular docking provided insight mode binding dna vitro experiments silico molecular docking studies concluded binds minor groove dna elsevier rights reserved
background calprotectin heterodimer complex proteins various functions innate mediator sites inflammation aim study elucidate roles calprotectin eosinophilic chronic rhinosinusitis ecrs methods allergen induced production calprotectin evaluated cultured normal human bronchial epithelial nhbe cells elisa pcr examined roles calprotectin alternaria altemata alternaria induced production thymic stromal lymphopoietin tslp nhbe cells extracellular concentration allergen induced secretion calprotectin cultured primary nasal epithelial pne cells examined compared patients ecrs noneosinophilic chronic rhinosinusitis necrs results altemaria house dust mites protease staphylococcus aureus papain trypsin polyinosinic polycytidylic acid lipopolysaccharide stimulated calprotectin production cultured nhbe cells combination calprotectin atp stimulated production tslp nhbe cells calprotectin stimulated altemaria induced production tslp suppressed blocking purinergic receptors treatment sirna calprotectin receptors toll like receptor receptor advanced glycation end products allergen induced calprotectin production significantly stimulated pne cells patients ecrs conclusions results indicate calprotectin enhances allergen induced type inflammatory responses airway epithelial cells via secretion tslp calprotectin secreted epithelial cells may involved pathogenesis ecrs copyright japanese society allergology production hosting elsevier
particulate air pollution becoming serious public health concern urban cities china association disability adjusted life years dalys economic loss air pollution related health effects demand quantitative analysis correctional measures air quality study applies epidemiology based exposure response function obtain quantitative estimate health impact particulate matter across cities china years annual average concentration ranging ranging respectively based present study total estimated annual premature mortality due confidence interval accounts adult cerebrovascular disease stroke ischemic heart disease ihd premature mortality megacities high chongqing year beijing year shanghai year tianjin year chengdu year pollution caused premature deaths age china cases chronic bronchitis cases asthma attack among ages copd related hospital admission cases respiratory related cerebrovascular cardiovascular related due pollution estimated chongqing beijing baoding tianjin shijiazhuang top five contributors pollution related mortality accounting respectively total deaths caused pollution total dalys associated pollution china million mortality chronic bronchitis shared total dalys period economic cost health impact due approximately million accounts china gross domestic product gdp megacities expected contribute relatively total costs present methodology could used tool help policy makers pollution control board authorities analyze costs benefits air pollution management programs china
audio description provides linguistic descriptions movies allows visually impaired people follow movie along peers descriptions design mainly visual thus naturally form interesting data source computer vision computational linguistics work propose novel dataset contains transcribed ads temporally aligned full length movies addition also collected aligned movie scripts used prior work compare two sources descriptions introduce large scale movie description challenge lsmdc contains parallel corpus sentences aligned video clips movies around video total goal challenge automatically generate descriptions movie clips first characterize dataset benchmarking different approaches generating video descriptions comparing ads scripts find ads visual describe precisely shown rather happen according scripts created prior movie production furthermore present compare results several teams participated challenges organized context two workshops iccv eccv
reported year old breast cancer patient referred nuclear medicine department sentinel node mapping planned undergo mastectomy lymphatic mapping dose phytate injection peri areolar region intra dermal fashion two hours post injection sentinel node visible axilla due high liver uptake inadvertent intra vascular injection suspected another dose radiotracer injected breast lymphoscintigraphy two minutes post injection showed axillary sentinel node case underscores importance second radiotracer injection case sentinel node non visualization
although various factors identified important successful briefing process studies appear undertaken comprehensive analysis using factor analysis systematically categorize views professionals relative importance briefing process critical success factors csfs paper intended fill research gap survey conducted hong kong united kingdom united states australia collect opinions construction professionals regarding csfs construction project briefing factor analysis reliability validity analyses following seven csfs established client business organization project requirements requirements stakeholders knowledge experience cultural background stakeholders decision making management skills senior project managers competence design team balanced interest stakeholders process briefing although research study involves limited sample size survey findings hands experience relevant industrial practitioners cross referenced similar investigations parts world international comparisons csfs systematically identified categorized enable practitioners construction industry manage briefing process successfully
background irritable bowel syndrome multifactorial disease although faecal calprotectin shown reliable marker intestinal inflammation role irritable bowel syndrome remains debated objective aims prospective study select subgroup irritable bowel syndrome patients characterise patients high faecal calprotectin systematic work methods calprotectin levels determined enzyme linked immunosorbent assay test consecutive irritable bowel syndrome patients fulfilling rome iii criteria normal colonoscopy appropriate tests excluded organic disease calprotectin levels compared irritable bowel syndrome patients healthy controls patients active quiescent crohn disease calprotectin level higher absence anca asca antibodies normal small bowel examination required confirm irritable bowel syndrome diagnosis additional explorations included assessment irritable bowel syndrome severity anxiety depression impact quality life glucose fructose breath tests rectal distension test barostat quantitative qualitative assessment inflammation colonic biopsies results among irritable bowel syndrome patients women diarrhoea recruited reproducibly elevated calprotectin although tended older normal calprotectin differences two groups elevated calprotectin correlated age conclusions elevated faecal calprotectin observed one third patients series without significant association specific clinical phenotype except age specific abnormalities
paper presents modeling approaches step grid connected photovoltaic systems intended provide analytical tools control design first approach based voltage source representation bulk capacitor interacting grid connected inverter common model large buses closed loop inverters second approach considers inverter double stage system norton equivalent widely accepted open loop inverters addition paper considers ideal realistic models converter interacts module providing four mathematical models cover wide range applications models expressed state space representation simplify use analysis control design also easily implemented simulation software matlab system analyzed demonstrate non minimum phase condition models important aspect select control technique moreover system observability controllability studied define design criteria finally analytical results illustrated means detailed simulations paper results validated experimental test bench
background objective date clinical trials evaluated therapeutic response among psoriasis patients switching ustekinumab secukinumab objective study report experience treating psoriasis patients secukinumab therapy ever received ustekinumab previously methods retrospectively reviewed therapeutic responses nine patients moderate severe psoriasis attended clinical trials first ustekinumab secukinumab ustekinumab given weeks patients evaluated safety efficacy weeks end ustekinumab treatment period patients treated needed modalities eligible patients recruited phase double blind secukinumab trial erasure secukinumab given weeks every weeks single evaluator performed assessments results among nine patients five patients least reduction psoriasis area severity index pasi score response four patients least reduction psoriasis area severity index pasi score response week secukinumab therapy prior experience ustekinumab therapy revealed least pasi response four patients least pasi response also four patients week mean absolute pasi change week secukinumab therapy patients conclusion biologic switch effective valuable patients ever responded ustekinumab seem better response secukinumab copyright taiwanese dermatological association published elsevier taiwan llc
paper studies heterogeneous effects birth control pill abortion rights young people career plans particular effects allowed vary sex race religion importantly level academic ability using annual surveys two million college freshmen find pill mainly affected high ability women shifting plans toward occupations higher wages higher male ratios abortion rights contrast mainly shown affect women low ability group plans shifting toward careers associated lower income lower prestige scores findings also suggest career plans black males positively affected increased access pill abortions published elsevier
paper presents underlying concerns uncovered literature reviews noticeable integration social cultural aspects part assessment indices green building rating tools towards holistic implementation social cultural values addition findings also resulted additional fourth experiential bottom line concept sustainability proposed shifting obsession increasing standards living towards focusing quality life exploratory research design adopts case study strategy study focuses socio cultural aspects matrilineal custom malay community malaysia authors published elsevier ltd
african caribbean black acb women canada disproportionately impacted new hiv infections acb women hiv vulnerability shaped contexts stigma discrimination hiv related stigma compromises quality life qol among women living hiv wlwh yet scant research examined concomitant effects racial discrimination hiv related stigma qol used data cross sectional survey acb wlwh ontario test conceptual model pathways hiv related stigma racial discrimination depression social support qol conducted structural equation modeling using maximum likelihood estimation test model independent models hiv related stigma associated lower qol depression partially mediated association hiv related stigma qol simultaneous model hiv related stigma significant direct effects depression social support indirect effect qol social support added mediator direct effect hiv related stigma qol longer significant suggesting mediation racial discrimination significant direct effects hiv related stigma depression social support indirect effect qol qol associated higher social support lower depression scores model fit data well degrees freedom comparative fit index cfi tucker lewis index tli root mean square error approximation rmsea found racial discrimination associated increased hiv related stigma hiv related stigma racial discrimination compromised qol findings suggest need multilevel interventions reduce stigma discrimination address depression build social support improve qol among acb wlwh
auditory approach proposes concept phonic mediation cantero key process teaching literacy consisting identifying prosodic units text access strategy reading comprehension recio multimodal structuring intonation gesticulation proved several pioneer works communication condon kondon recently torregrosa shows kinesic intonational costructuring key aspect oral code taking account conceptual framework provide new didactic clues related strategies early reading considering relationship auditory approach reading multimodal costructuring intonation gesticulation discourse
study aimed determine pain balance control related meteorological modifications patients knee osteoarthritis one hundred thirteen patients knee mean age years old women participated study static posturography performed sway area covered sway path traveled center foot pressure recorded six standing postural conditions combine three visual situations eyes open eyes closed vision altered two platform situations firm foam supports knee pain score assessed using visual analog scale balance control pain measurements recorded morning correlated meteorological data morning daily values temperature precipitation sunshine height rain wind speed humidity atmospheric pressure obtained nearest data collecting weather station relationship postural control pain weather variations assessed patient given day multiple linear regressions decrease postural stability observed atmospheric pressure maximum humidity decreased morning atmospheric pressure decreased within day patient knee pain enhanced warmer morning wetter warmer within day relationship weather pain postural control help patients health professionals better manage daily activities
objective fabricate orthodontic brackets esthetic materials determine fracture resistance archwire torsion materials methods computer aided design computer aided manufacturing technology cerec inlab sirona used mill brackets inch slot materials used paradigm lava ultimate resin composite espe mark feldspathic porcelain vita zahnfabrik ceram zirconia vita zahnfabrik ten brackets material subjected torque inch stainless steel archwire using specially designed apparatus average moments degrees torsion necessary fracture brackets determined compared commercially available alumina brackets mystique dentsply gac results brackets statistically significantly stronger tested material resistance torsion mean torques failure ranged mark mean torsion angles failure ranged degrees conclusion zirconia highest torsional strength among tested esthetic brackets resistance lava ultimate composite resin brackets archwire torsion comparable commercially available alumina ceramic brackets
first attempts apply induction method software verification recent paper present novel proof induction algorithm built top symbolic context bounded model checker uses iterative deepening approach verify step given maximum whether given safety property phi holds program proposed induction algorithm consists three different cases called base case forward condition inductive step intuitively base case aim find counterexample loop unwindings forward condition check whether loops fully unrolled holds states reachable within unwindings inductive step check whenever holds unwindings also holds next unwinding system algorithm implemented two different ways sequential parallel one results compared experimental results show forms algorithm handle wide variety safety properties extracted standard benchmarks ranging reachability time constraints comparison parallel algorithm solves verification tasks less time paper marks first application induction algorithm broader range programs particular show induction method outperforms cpachecker terms correct results state art induction based verification tool programs
background patients diabetes mellitus followed primary care physicians often lack knowledge confidence prescribe insulin properly contributes clinical inertia poor glycemic control effectiveness traditional continuing medical education cme solve limited new approaches required electronic games good option effective easily disseminated objective objective study assess applicability user acceptance educational effectiveness insuonline electronic serious game medical education insulin therapy compared traditional cme activity methods primary care physicians pcps south brazil invited phone email participate unblinded randomized controlled trial randomly allocated play game insuonline installed app computers time choice minimal external guidance participate traditional cme session composed onsite lectures cases discussion interventions content duration similar applicability assessed number subjects completed assigned intervention group insulin prescribing competence factual knowledge problem solving skills attitudes self assessed questionnaire applied immediately months interventions acceptance intervention satisfaction perceived importance clinical practice also assessed immediately months interventions respectively results subjects characteristics similar groups mean age male game group completed intervention compared control group difference applicability percentage right answers competence subscale baseline groups significantly improved immediately interventions game group control months remained significantly higher baseline groups game control absolute increase competence score better game traditional cme insulin related attitudes improved game significant improvement items control activity interventions well accepted subjects rating fun pleasant useful practice changing conclusions game insuonline applicable well accepted highly effective medical education insulin therapy view flexibility easy dissemination valid option large scale cme potentially helping reduce clinical inertia improve quality care patients
investigated serial japanese forensic autopsy cases years old mean age case selection using immunohistochemistry detect cases progressive supranuclear palsy psp twenty nine cases mean age years males females fulfilled national institute neuronal disorders stroke ninds psp pathological criteria cases cases neuronal glial inclusions basal ganglia brainstem however cases low tau pathology categorized atypical psp addition psp pathology multiple types astrocytic inclusions comorbid proteinopathies particularly high prevalence argyrophilic grain disease found cases diagnosed psp preserved daily functioning prior death however cases showed signs dementia depressive state gait disturbance respectively sixteen accidental death cases including falls getting lost suicide cases appear relationship incipient psp pathology cluster analysis using distribution amount repeat tau pathology classified cases three subgroups group cases typical psp pathology seven cases dementia frequent symptom group cases significantly higher frequency gait disorder cases less neocortical tau pathology group group cases relatively mild psp pathology high argyrophilic grain burdens granular shaped astrocytes dominant astrocytic inclusion cases conclude forensic cases incipient psp occurs higher prevalence expected findings extrapolated population based cohorts psp may common previously thought
paper highlights various solutions travelling salesman problem hence comparative study solutions performed conclude methodology algorithm suits problem appropriately today world process needs faster quicker comparative study performed taking running time major criteria paper slight introduction along respective algorithms analysis inference
objectives conducted systematic literature review identify studies fulfilling good scientific epidemiological standards use meta analyses relevant risk factors parkinson disease methods search identified original publications associations work parkinson disease grade guidelines used ensure high scientific quality reliable guidelines applied classify papers articles fulfilled good scientific standards methodologically deficient thus excluded meta analyses results total publications concerned work exposure pesticides weighted relative risk estimate confidence interval funnel plot bias test indicated publication bias concerning smaller studies might present risk estimate influenced study design casecontrol cohort cross sectional study gender higher estimates found hereditary taint onset age studies exposure metals electromagnetic fields show increased risk conclusions using elaborated quality protocol strong evidence exposure pesticide involves increased risk developing parkinson disease
global software development exposes projects challenges arising geo cultural spread team delegation project ownership therefore risk management global software development receives attention many researchers today primary focus paper investigation risks associated maintenance information systems teams distributed across geographical locations cultures vendors authors present case study large offshore outsourced program maintained portfolio business applications fortune client program exhibited wide variety characteristics typical maintenance projects study investigated risks risk resolution techniques lessons learned best practices adopted program vendor perspective findings provide useful insights understanding responding challenges initiating transitioning managing global software maintenance projects
background objectives though studies reported high prevalence rates metabolic syndrome among patients bipolar disorder bpad schizophrenia lack data impact patients life study aimed assess lifestyle related factors associated metabolic syndrome mets study impact mets functioning quality life qol patients bpad schizophrenia methods total patients bpad patients schizophrenia attending output unit tertiary care hospital north india evaluated mets patients assessed health promoting lifestyle profile scale hplp world health organization qol bref version whoqol bref impact weight quality life lite version iwoqol lite body weight image self esteem evaluation questionnaire bwise obesity related problem scale scale global assessment functioning gaf scale results mets associated lower scores domains health responsibility nutrition habit domain hplp scale groups additionally physical activity stress management domain bpad group whoqol bref mets associated lower scores domains physical psychological health groups iwqol lite scores personal distress self esteem domains higher obesity groups also physical activity domain schizophrenia group mets lower level functioning measured gaf schizophrenia group fulfillment higher number criteria mets correlated poorer quality life higher problems groups interpretation conclusions many modifiable lifestyle factors increase risk mets mets found associated poorer qol patients bpad schizophrenia addition obesity led poor self esteem excessive personal distress
present research analyzed whether emoticons could exploited proxies nonverbal behavior inserted online discussions specifically prior research recommended women communal concentrated forming interpersonal bonds may able form bonds effortlessly communicating via email lack nonverbal cues guadagno cialdini anticipated inserting emoticons persuasive online communication women would exposed persuasion compared women saw emoticons whereas expected matter men total men women completed study contrast predictions results specified exploiting verbal equivalent emoticon online discussion essentially produced favorability towards message men women furthermore results revealed individuals level femininity foreseen attitude towards topic similarly verbal equivalent proxy influenced positive mood may also help clarify results implications persuasion vial online devices discussed
background tobacco smoke exposure increases breathing problems children texas children health plan managed medicaid children health insurance program chip managed care provider aim study determine associations among tobacco smoke exposure asthma prevalence asthma health care utilization methods texas children health plan conducts annual survey members physician visit questions added survey march asthma tobacco smoke exposure survey results children years age matched health plan claims data months following date physician visit results total parents unique members patients birth years age participated survey whites african americans hispanics report child mother smoker respectively compared children whose mother smoke parent report asthma diagnosis claims dispensing short acting beta agonist medication greater mother smoker adjusted respectively contrast medicaid pocket costs chip line business requires copays visits visits influenced maternal smoking chip line business adjusted conclusion maternal smoking increases risk asthma diagnosis prescription asthma quick relief medication maternal smoking predicted asthma related visits chip line business
project based learning techniques given rise learning techniques research works based learning rwbl technique especially interested teching learning process materials processing technologies related disciplines work reports results application rwbl techniques subject cadiz university master manufacturing engineering engineering non conventional materials removing processes proposed research works designed basis classic research paper structure introduction state art experimental procedure results discussion conclusions proposed works focused comparative analysis different machining processes mainly electro discharge machining abrasive waterjet machining high speed machining experience considered highly successful students reached learning objectives subject
long slender elastic structures railroad tracks pipelines pavements may experience buckling owing axial compressive forces developed result thermal effects many cases structures simplified beam elastic foundation paper presents investigation critical buckling postbuckling elastic structure nonlinear foundation softening restabilizing effects method minimization total potential energy beam foundation system invoked develop differential equation equilibrium differential equation critical buckling bifurcation beam analysis shows critical buckling may symmetric antisymmetric mode depending length beam length extremely large two buckling modes indistinguishable equations postbuckling equilibrium beam highly nonlinear elucidate response beam multiple scale perturbation technique used modal analysis numerical solution based shooting technique developed shown postbuckling equilibrium beam two stages critical buckling postbuckling localization stage unstable subsequent postbuckling snaking stage characterized zigzag equilibrium configuration snaking stage dependent relative effects softening restabilizing parameters comparisons perturbation solutions results numerical formulation show former semianalytical technique accurate initial stages postbuckling localization develops subsequent snaking stage effect foundation parameters also investigated paper american society civil engineers
objective study efficacy adverse events different pharmacological lines treatment idiopathic overactive bladder ioab methods pubmed research meta analyses randomized controlled trials rct focused efficacy adverse effects anticholinergics botulinum toxin mirabegron since results ten meta analyses anticholinergics selected randomized controlled trials erc comparing botulinum toxin either anticholinergic placebo erc studying mirabegron molecules studied showed efficacy compared placebo treatment ioab anticholinergics remain first line pharmacological treatment allowing significant reduction number incontinence week number urination week well perception subjective improvement symptoms reported patients treated placebo group commonly reported side effect dry mouth placebo group injections botulinum toxin appear relatively comparable anticholinergics first line decrease urinary emergency incontinence uti toxin group versus anticholinergic group also higher rate complete resolution urinary incontinence toxin group significant adverse effects lower urinary tract infections risk using self catheterization view invasive character toxin injections side effects treatment remains line therapy true mirabegron similar efficacy iuu number mirabegron group solifenacin group different side effects arterial hypertension oral dryness rate comparable placebo group choice use anticholinergic mirabegron based balance efficacy tolerance estimated patient conclusion different molecules shown efficacy treatment ioab acceptable tolerance lack direct comparisons treatments available studies needed evaluate possible interest combination molecules well search predictive factors response different therapies elsevier masson sas rights reserved
home solar systems promise bringing great welfare benefits poor households without access electricity grid study welfare impacts brought purchase popular home solar system uganda light estimate impacts using prospective individual level matching find substantial impacts energy spending treatment households saving approximately usd week corresponds per cent comparison group weekly energy expenditure assuming savings stays constant households break even initial purchase years accrue net energy savings usd year expected lifetime also find improved self reported health safety outcomes treatment households reported fewer lower incidence coughing percentage points also report nearly complete elimination fires burns lighting sources compared around per cent households reporting incidents comparison group find impact productive time use studying working
rationale temporal fluctuations demonstrated lung function asthma control effect controller therapy fluctuations unknown objectives determine fluctuations peak expiratory flow pef predictive subsequent treatment failure may modified controller therapy methods applied detrended fluctuation analysis daily pef data participants loccs leukotriene modifier corticosteroid corticosteroid salmeterol trial american lung association airways clinical research centers evaluated coefficient variation pef cvpef scaling exponent alpha reflecting self similarity pef relation treatment failure run period open label inhaled fluticasone treatment periods subjects randomized continued twice daily fluticasone daily fluticasone plus salmeterol daily oral montelukast measurements main results cvpef higher treatment failure groups run phase three groups treatment phase alpha similar without treatment failure three groups run phase higher among treatment failure groups treatment phase participants three groups showed variable patterns change alpha leading treatment failure conclusions conclude increased temporal self similarity alpha variable lung function cvpef associated treatment failure pattern change self similarity leading treatment failure variable across individuals
parkinson disease slowly progressing neurodegenerative disorder affects approximately seven million patients worldwide despite intensive research molecular mechanisms initiating promoting still unknown however assumed environmental factors trigger recent research demonstrated long noncoding rnas lncrna interfere transcriptional translational processes modulating gene expression reflecting environmental influences nevertheless systematic analysis available investigates impact lncrnas current study performed comprehensive analysis expression levels well annotated lncrnas brain specimens deriving patients controls preliminary report significance lncrnas expression profiling lncrnas revealed five lncrnas significantly differentially expressed upstream conserved significantly downregulated lincrna malat snhg tncrna significantly upregulated analysis expression levels stages revealed identified dysregulated lncrna altered already early disease stage precede course summary first comprehensive analysis lncrnas revealing significantly altered lncrnas additionally found lncrna dysregulations precede course disease thus five newly identified lncrnas may serve potential new biomarkers appropriate even early may used monitoring disease progression may serve potential new targets novel therapeutic approaches
application digital control problem one step delay appears limits achievable control bandwidth compared one step delay minimized delay achieve superior performance however leads low frequency aliasing phenomenon sampling happened middle either turn turn times igbt weaken influence aliasing reduce total harmonics distortion thd output current strategy reducing inductor current feedback coefficient adjusting non dominant poles proposed simulation experimental results provided verify feasibility effectiveness scheme
identifying dependencies hold relational databases essential produce good databases designs particular functional multivalued dependencies used obtain relation schemes satisfy normal form property considered satisfactory applications known class sets functional dependencies learnable exact model learning queries also subclass multivalued dependencies class consequent restricted multivalued dependencies shown learnable model paper present algorithm learns class contains sets functional multivalued dependencies restrictions imposed antecedents dependencies also show product algorithm learns non trivial subclass quasi horn formulas closely related class mentioned
individuals substance use disorders sud high rates chronic illness readmission yet engaged addiction treatment hospitalization may reachable moment initiating coordinating addiction care little known motivation change inpatient setting explore experiences hospitalized adults sud better understand patient system level factors impacting readiness change performed qualitative study using individual interviews study nested within larger mixed methods needs assessment hospitalized adults admitted medical surgical units urban academic medical center reported high risk alcohol drug use audit single item drug use screener conducted thematic analysis using inductive approach semantic level thirty two patients participated mean age years men identified white participants reported moderate high risk alcohol amphetamine opioid use emergent themes highlight influence hospitalization patient provider health system levels many patients experienced hospitalization wake call mortality motivation change hospitalization disrupted substance use however many participants voiced complex narratives social chaos trauma homelessness chronic pain participants valued providers understood sud importance treatment choice patient experience suggests importance peers hospital setting access medication assisted treatment coordinated care post discharge study supports hospitalization offers opportunity initiate coordinate addiction care provides insights patient provider health system factors leverage reachability moment
compact add model proposed simulate mechanism charge trapping release detrapping effect threshold voltage mosfet devices model uses implicit algebraic differential equations compatible transient analysis spice also shares accuracy level transient analysis micro model approach used trap treated two state markov process normalization trap behavior enabled disabled designer compare average trap behavior result repeated monte carlo simulations circuit manner model compromise device level modeling circuit level modeling unlike models geared towards digital circuit design trapping release rates need constant electrical stress trapping release rates function time depend circuit state space equations operational amplifier analyzed using new model proposed approach compared state art elsevier ltd rights reserved
langerhans cell sarcoma lcs quintuple cancers extremely rare report case quintuple cancers including lcs described year old man squamous cell carcinoma nasal skin colon rectum adenocarcinomas cell histiocyte rich large cell lymphoma swelling multiple submental lymph nodes observed fine needle aspiration carried many large cells high grade nuclear atypia abundant cytoplasm observed lymphocytes eosinophils observed background although malignant tumor suspected definite diagnosis could made biopsy sample tumor cells positive vimentin cda negative epithelial lymphocyte melanoma markers immunohistochemistry diagnosis lcs made immunohistochemical findings high mitotic rate atypical forms patient died months first medical examination metastasis lcs confirmed many organs autopsy lcs poor prognosis cases described cytological findings lcs added list differential diagnosis cytological findings presented may useful determining appropriate clinical management staging disease follow neoplasm diagn cytopathol authors diagnostic cytopathology published wiley periodicals inc
study explores use tcsc technologies improve interaction lines vsc hvdc links form parallel circuit purpose connection reinforcement transmission paths facilitate integration new wind generation dogger bank mainland electrical network elsevier ltd open access article license http creativecommons org licenses
objective use expert consensus inform development policy guidelines treatment management monitoring physical health people enduring psychotic illness method delphi method used systematic search websites books journal articles conducted develop item survey containing strategies health professionals use treat manage monitor physical health people enduring psychotic illness three panels australian experts clinicians carers consumers recruited independently rated items three rounds strategies reaching consensus priori defined levels importance written expert consensus statement results participation rate clinicians across three rounds consumers carers completing one round due high endorsement rates finally strategies endorsed essential important one panels endorsed strategies provided information engagement collaborative partnerships clinical governance risk factors morbidity mortality people enduring psychotic illness assessment including initial follow assessments barriers care strategies improve care people enduring psychotic illness education training treatment recommendations medication side effects role health professionals conclusion consensus statement intended used health professionals people enduring psychotic illness families carers next step needed implementation strategy royal australian new zealand college psychiatrists stakeholders
background veterans work veterans health administration vha peer specialists pss pss veterans formal training provide support veterans similar diagnoses primarily mental health settings white house executive action mandated pilot reassignment vha pss mental health primary care patient aligned care teams pact order broaden provision wellness services address many chronic illnesses evaluation initiative undertaken assess impact outside assistance deployment pact implementation support often needed prevent challenges commonly experienced first deploying pss vha settings present protocol cluster randomized hybrid type trial test impact standard implementation receive minimal assistance facilitated implementation receive outside assistance deployment vha pss pact methods vha office mental health services work group recruiting veterans affairs medical centers reassign mental health pss provide wellness oriented care pact sites three successive cohorts beginning month blocks matched randomized either standard facilitated implementation facilitated implementation outside expert works site stakeholders site visit regular calls performance data guide planning address challenges standard implementation sites receive webinar access office mental health services work group two conditions compared workload data fidelity model service delivery team functioning veteran measures activation satisfaction functioning qualitative interviews collect information implementation barriers facilitators discussion evaluation provide critical data guide administrators vha policy makers future deployment pss role expanding beyond mental health addition development novel implementation strategies facilitation tailored pss use new tools peer fidelity models monitoring supporting deployment pss throughout vha
background athletes typically maintain rigorous training work programs able participate competitions injury occurs competition causes withdrawal competition possible departure sports render results athletes support staff efforts meaningless early detection injuries competition developing preventive training programs help ensure participating competitions associated preparatory efforts wasted study sports injuries discussed occurred training competition events turkish shooting sportive group body parts injuries determined exercise programs focused affected body parts developed methods total athletes female male participated turkish shooting sports championship competition period participated study athletes given questionnaire developed prior event questionnaire filled interviews conducted one one data collected questionnaire spss used analyze results study completed six months results results showed injuries occurred training strain muscle tears whereas injuries occurred actual competition strain muscle tears tendinitis sprain results also indicated training frequently occurring injuries shoulder calf thigh hand wrist whereas competition manifested shoulder foot ankle conclusions muscle strengthening stretching proprioception exercises body parts included part athletic training program
identifying smokers high risk relapse could improve effectiveness cessation therapies although altered regional brain function smokers reported whether whole brain functional organization differs smokers relapse vulnerability others remains unclear thus goal study investigate baseline functional connectivity differences relapsers quitters using resting state fmri acquired images smokers prior quitting attempts week treatment varenicline smokers divided relapsers quitters quitter continuously abstinent weeks smoking cessation outcomes cross validated self reports expired carbon monoxide used eigenvector centrality mapping identify functional connectivity differences relapsers quitters compared quitters increased right dorsolateral prefrontal cortex dlpfc left middle temporal gyrus mtg cerebellum anterior lobe observed relapsers addition logistic regression analysis data dlpfc mtg cerebellum included predicted relapse accuracy findings suggest dlpfc mtg cerebellum may important substrates smoking relapse vulnerability data also suggest relapse vulnerable smokers identified quit attempts could enable personalized treatment improve smoking cessation outcomes elsevier inc rights reserved
critical aspect applying modern computational solution methods complex multi physics systems relevance nuclear reactor modeling assessment predictive capability specific proposed mathematical models respect understanding numerical error sensitivity solution parameters associated input data boundary condition uncertainty mathematical models critical additionally ability evaluate approximate model efficiently allow development reasonable level statistical diagnostics mathematical model physical system central importance study report initial efforts apply integrated adjoint based computational analysis automatic differentiation tools begin address issues study carried context reynolds averaged navier stokes approximation turbulent fluid flow heat transfer using particular spatial discretization based implicit fully coupled stabilized methods initial results presented show promise computational techniques context nuclear reactor relevant prototype thermal hydraulics problems published elsevier inc
smiling individuals usually perceived favorably non smiling ones judged happier attractive competent friendly seemingly clear obvious consequences smiling assumed culturally universal however psychological research carried weird societies western educated industrialized rich democratic influence culture social perception nonverbal behavior still understudied show smiling individual may judged less intelligent non smiling individual cultures low globe uncertainty avoidance dimension furthermore show corruption societal level may undermine prosocial perception smiling societies high corruption indicators trust toward smiling individuals reduced research fosters understanding cultural framework surrounding nonverbal communication processes reveals cultures smiling may lead negative attributions
electric motor drive emd systems ubiquitous developed society falls profession engineering utilise benefit society successful engineering practice emd systems requires wide range knowledge applied skill university training expected provide engineering teaching laboratories key way providing training development significant undertaking paper describes development engineering teaching laboratory intended prepare student engineers industrial practice outlining motivation creation lab pedagogical design imperatives describing final technical configuration equipment used successfully teach undergraduate postgraduate students
paper describes use parallelization techniques reduce dynamic power consumption hardware implementations trivium stream cipher trivium synchronous stream cipher based combination three non linear feedback shift registers chosen finalist hardware profile estream project power consumption values compared verified proposed low power trivium designs implemented characterized standard cell technology transistors gate level models order permit electrical logical simulations results show two designs decreased average power consumption virtually performance loss slight overhead area copyright john wiley sons ltd
wastewater stabilization ponds wsps common wastewater treatment remote canadian arctic communities paper two geotextiles different mass unit areas examined potential biofiltration upgrade existing wsps arctic summer conditions intended role geotextile provide additional treatment municipal wastewater seeping wsps column filtration experiments performed using municipal wastewater controlled laboratory environment either degrees degrees columns contained one two different nonwoven geotextiles gravel simulating wsp berm contact exfiltrating wastewater weekly wastewater samples taken upstream downstream geotextile gravel filter analyzed suite water quality parameters hydraulic conductivity columns also measured weekly results showed possible accumulate biomass geotextile material month period temperatures corresponded log reductions hydraulic conductivity significant removal total suspended solids day biochemical oxygen demand total nitrogen total phosphorus observed however removal efficiencies parameters reduced lower temperature study demonstrates geotextiles could used enhance performance wsp systems operating arctic climates elsevier ltd rights reserved
introduction steroid hormone based contraceptives used women long time since introduction efforts made make steroidal contraceptives cost effective safe improve users compliance addition attempts made develop nonsteroidal contraceptives contraceptive vaccines investigated alternate strategy contraception areas covered currently used steroidal contraceptives reviewed addition status emerging nonsteroidal contraceptives inhibit folliculogenesis oocyte maturation ovulation endometrium receptivity targeting phosphodiesterase angiopoietins gonadotropin releasing hormone cox progesterone estrogen receptor follicle stimulating hormone receptor presented various approaches develop contraceptive vaccines aiming inhibit ovarian follicle development ovulation fertilization implantation including current applications limitations discussed expert opinion development new nonsteroidal contraceptives addition long acting steroidal contraceptives pertinent offering wider choice women imperative basic research discover new targets ovaries must undertaken facilitate development novel contraceptives efforts studying feasibility safety contraceptive vaccines may continued bring within realm application contraceptives humans
chronic social behavior problems pediatric traumatic brain injury tbi significantly contribute poor quality life survivors using well characterized mouse model early childhood tbi previously demonstrated young brain injured mice develop social deficits adulthood biological sex may influence normal aberrant social development evaluated potential sex differences post tbi psychosocial deficits comparing behavior male female mice adulthood weeks post injury secondly hypothesized pediatric tbi would influence neuronal morphology identified golgi cox staining hippocampus prefrontal cortex regions involved social cognition behavior onset social problems weeks post injury morphological analysis pyramidal neurons ipsilateral prefrontal cortex granule cells hippocampal dentate gyrus revealed reduction dendritic complexity pediatric tbi apparent tbi males whereas neurons females less affected adulthood consistent previous studies tbi males showed deficits sociability social recognition tbi females also showed reduction sociability intact social recognition increased sociosexual avoidance together findings indicate sex determinant regional neuroplasticity social outcomes pediatric tbi reduced neuronal complexity prefrontal cortex hippocampus several weeks injury male mice appears precede subsequent emergence social deficits sex specific alterations social brain network thus implicated underlying mechanism social dysfunction pediatric tbi elsevier rights reserved
software architectural style one best concepts define family related architectures common properties despite essential role software architectures software engineering practice lack formal description analysis may hamper quality designed models hence using proper formal languages seems necessary architectural style description case possible use model checking verify designed models automatically however model checking complex software systems suffers state space explosion problem handle problem data mining techniques may contribute obtain required knowledge intelligent model checking searching portion state space paper check model complex software systems designed according architectural style efficient approach proposed using data mining techniques software systems must specified architectural styles modeled graph transformation systems gts formally proposed approach check large model based specific style intelligently specific knowledge required knowledge acquired mining data checking smaller model consistent style smaller models designed either designers automatically generated consistent style proposed solution used verify reachability property refute safety liveness properties solution implemented groove toolset designing model checking graph transformation systems experimental results show method faster accurate comparison existing techniques model checking complex software systems elsevier rights reserved
increasing number studies reported protective association vitamin cancer risk vitamin endocrine system regulates transcriptional programs involved inflammation cell growth differentiation binding vitamin receptor vdr specific vdr elements however limited attention given role variation within vdr binding sites development basal cell carcinoma bcc across previously identified vdr binding sites identified independent single nucleotide polymorphisms snps examined associations bcc risk genome wide association meta analysis totaling bcc cases controls two data sets multiple testing corrections identified two snps new loci odds ratio first time independently related bcc risk meta analysis snps nominally significant two data sets addition snp within vdr binding site previously reported bcc susceptibility locus also exhibited significant association mutually adjusted model suggested explained signal region findings support hypothesis inherited common variation vdr binding sites affects development bcc
background recurrent respiratory tract infections rrtis negative impact children health family wellbeing deficiency zhengqi used instinct factor driving rrti traditional chinese medicine tcm clinical observations suggest children gastrointestinal heat retention syndrome ghrs may greater risk catching respiratory tract infections rtis ghrs new predisposing factor rrti dietary related study aimed explore association ghrs rrti methods prospective cohort study conducted beijing china children aged enrolled tcm symptoms demographic physiological characteristics recorded using semi structured questionnaire ghrs considered predisposing factor children followed next months contacted parents using face face questionnaire survey via email phone every months episodes rtis recorded detail results three hundred thirty four children enrolled followed months incidence rti episodes per child year children group ghrs suffered rrti children group without ghrs risk ratio value rrti occurrence attributable risk percent dry stool irritability positively correlated rti episodes age bmi negatively correlated rti episodes linear regression model dry stool positively correlated rrti occurrence age bmi negatively correlated rrti occurrence logistic regression model conclusions ghrs associated rrti cohort dry stool positively associated rrti bmi negatively associated rrti studies larger sample size longer follow needed evaluate association relieving ghrs considered tcm practitioners treat rrti children may protect children suffering rtis
recent years silting xiaobeiganliu reaches yellow river serious causing new problems river flood control engineering layout works defense based practice yellow river harnessing paper analyzes problems existing harnessing xiaobeiganliu reaches yellow river six aspects namely channel flood discharge capacity declined river pattern effectively controlled phenomenon serious danger caused mere small flood occurred frequently floodplain land suffered serious salinization construction standard flood control roads low construction flood control non engineering measures lagged behind put forward harnessing measures carrying water sediment regulation carrying research law bottom tearing scouring speeding construction river harnessing projects building village protective projects raising construction standard floodplain roads making preparation earlier flood control emergency rescue strengthen construction flood control non engineering measures
background delayed inappropriate treatment sexually transmitted diseases stds increases risk hiv acquisition may cause harmful outcomes however studies std treatment seeking behaviour correlated factors men sex men msm scarce information crucial promotion std treatment seeking behaviour reduction hiv transmission among chinese msm methods multicentre cross sectional study conducted chinese cities participants completed interview questionnaire gave venous blood samples tested antibodies hiv syphilis herpes simplex virus hsv msm tested positive syphilis hsv obvious std related symptoms within last months defined suspected std infected msm results eligible msm completed survey categorized suspected std infected msm msm suspected std infections sought std treatment clinics within last months among msm attend std clinics treatment prevalence syphilis hsv significantly higher hiv prevalence incidence within subpopulation reached high person years respectively multivariate logistic regression analysis indicated years education years education usd usd aor obvious std related symptoms within last months aor hiv infected aor currently syphilis infected aor hsv infected aor independent correlates seeking std treatment clinics among chinese msm conclusions high prevalence std infection coupled low proportion individuals exhibit appropriate treatment seeking behaviour create high risk growing hiv epidemic among chinese msm models prioritize better screening education stds urgently implemented especially among low income msm
paper presents novel skeleton design avatar animation design includes new bones whose purpose meet requirements sign language synthesis synthesis presents particular challenges regarding processing phonetic descriptions signs create animations although traditional animation techniques solved synthesis signs proposed skeleton design allows simplification phonetic processing inverse kinematics calculations collision avoidance processes proposed design tested demonstrate generated animations quality ones produced state art techniques importantly proposed structure reduces time required generating animation compared existing solutions requires less storage resources
objective identify factors contributing occurrence unintended pregnancies essure sterilization netherlands even though essure permanent method contraception unintended pregnancies reported design retrospective case series analysis setting applicable patient thirty five pregnancies reported netherlands essure sterilization placements intervention data regarding essure placement procedure confirmation tests pregnancy outcome reported cases obtained analyzed identify possible cause failure main outcome measure four causes failure identified perforation expulsion unilateral placement luteal pregnancy result occurrence pregnancies related physician noncompliance cases associated patient noncompliance misinterpretation confirmation test pregnancies occurred within first months month confirmation test conclusion results study show incidence pregnancies essure sterilization low pregnancies related incorrect positioning device unilateral placement seem therefore preventable unilateral placement without prior history salpingectomy always considered unsuccessful sterilization furthermore interpretation confirmation tests done trained physicians caution want emphasize importance strictly adhering placement follow protocols american society reproductive medicine
rheumatoid arthritis neoangiogenesis early crucial event promote development hyperplasic proliferative pathologic synovium endothelial cells critical formation newblood vessels since highly contribute angiogenesis vasculogenesis current therapies target inflammatory consequences autoimmune activation despite major improvements last years still refractory patients incomplete responders may seen raising point need identify complementary additive innovative therapies review resumes themechanisms synovial neoangiogenesis including recent insights implication vasculogenesis regulation synovial neoangiogenesis angiogenic inflammatory mediators line recent development vascular targeted therapies used cancer beyond also discuss possible therapeutic implications particular combination targeted immunotherapies anti angiogenic molecules elsevier rights reserved
search based structured prediction methods shown promising successes computer vision natural language processing recently however existing searchbased approaches lead complex multi stage learning process ill suited scene labeling problems highdimensional output space paper stacked learning search method proposed address scene labeling tasks design simplified search process consisting sequence ranking functions learned based stacked learning strategy prevent fitting method able encode rich prior knowledge incorporating variety local global scene features addition estimate labeling confidence map improve search efficiency two aspects first constrains search space effectively pruning low quality solutions based confidence scores second employ confidence map additional ranking feature improve prediction performance thus reduce search steps approach evaluated semantic segmentation geometric labeling tasks including stanford background sift flow geometric context nyuv rgb data set competitive results demonstrate stacked learning search method provides effective alternative paradigm scene labeling
patients borderline personality disorder bpd high utilizers psychiatric emergency services present unique challenges setting frequently advised visit emergency department safety question experiences often beneficial effects issues specific patients bpd include volatile interactions staff repeat visits concerns safety liability disposition emergency department staff attitudes toward patients frequently negative compared patients diagnoses detrimentally affect outcomes perpetuate stigma regarding bpd attitudes often due lack education training understand approach treat patient bpd limited literature regarding treatment bpd offers guidelines article presents approach based good psychiatric management reduce negative reactions staff make visits effective less harmful relevant principles include psychoeducation reinforcement connection symptoms interpersonal stressors employment active authentic therapeutic stance training staff principles could lead attitudinal changes reduced stigma potentially improved outcomes
backgroundwomen endometriosis frequently misdiagnosed irritable bowel syndrome ibs time correct diagnosis made visceral hypersensitivity key feature conditions aimsto determine distinct symptom patterns women ibs endometriosis determine response women low fodmap diet comparison ibs alone materials methodsa retrospective analysis prospectively collected data women attending specialist ibs service christchurch new zealand data met rome iii criteria ibs sorted two groups concurrent endometriosis ibs alone demographics symptom patterns identified prospective questionnaire low fodmap fermentable oligosaccharides disaccharides monosaccharides polyols diet taught women primary therapeutic intervention responses diet noted ultimate disposition resultsof women met rome iii criteria ibs concurrent endometriosis presence dyspareunia referred pain bowel symptoms exacerbated menstruation family history endometriosis associated concurrent endometriosis seventy two percent women reported improvement bowel symptoms four weeks low fodmap diet compared known endometriosis odds ratio conclusionswomen concurrent endometriosis ibs report unique symptom phenotype low fodmap diet appears effective women gut symptoms endometriosis
introduction decades progestins included hormone therapies prescribed women offset risk unopposed estrogen induced endometrial hyperplasia however potential effects cognition subcategories clinically used progestins largely unexplored methods two studies present investigation evaluated cognitive effects norethindrone acetate neta levonorgestrel levo medroxyprogesterone acetate mpa water radial arm maze wram morris water maze middle aged ovariectomized rats results study six weeks high dose neta treatment impaired learning delayed retention wram impaired reference memory low dose neta treatment impaired delayed retention wram study high dose neta treatment reduced four weeks compared mpa levo previously shown mpa impaired working memory performance latter portion testing highest working memory load impaired delayed retention wram impaired reference memory neta also impaired performance wram measures interestingly levo impair performance instead enhanced learning wram conclusions current study corroborates previous evidence commonly prescribed fda approved progestin mpa impairs learning memory ovariectomized middle aged rat progestins two different additional subcategories investigated neta impaired learning memory similarly mpa levo enhanced learning future research warranted determine levo potential ideal progestin optimal health women including cognition elsevier rights reserved
electrorheological magnetorheological fluids based electro magneto responsive particles respectively smart suspensions ability undergo phase transitions liquid like solid like state result stimuli electric magnetic field application polymer composite materials rather pure polymeric inorganic materials aiming solve problems use materials low activity physical chemical stability production cost various fabrication methods polymer composite materials electro activity magneto activity developed effectively applied field boost wide commercialization fluids briefly reviewed perspective society chemical industry
computer programming complex personality factors might influence personality factors comprehensive broad therefore lower level traits may help understanding influence personality computer programming objective paper extend empirical knowledge software psychology using narrow personality traits well broad personality traits explain influence personality authors surveyed programming students developing software projects investigate influence personality performance computer programming measured five broad personality factors personality facets prior experience attitude self assessed survey performance also used grade students achieved software projects indicator software quality found prior programming experience attitude towards programming academic performance openness experience conscientiousness extraversion agreeableness positive effect performance computer programming however one facet openness experience facets neuroticism revealed negative effect authors found indication different aspects personality factors different influences computer programming personality facets show larger effect personality help explaining influence personality studies needed strengthen findings clarify situation
interesting emerging topic saliency detection aims simultaneously extracting common salient objects group images one hand traditional saliency detection approaches rely heavily human knowledge designing hand crafted metrics possibly reflect faithful properties salient regions strategies however always suffer poor generalization capability flexibly adapt various scenarios real applications hand current methods pursue saliency detection unsupervised fashions however tends weaken performance real complex scenarios lack robust learning mechanism make full use weak labels image alleviate two problems paper proposes new mil framework saliency detection integrates multiple instance learning mil self paced learning spl unified learning framework specifically first problem formulate saliency detection problem mil paradigm learn discriminative classifiers detect saliency object instance level formulated mil component facilitates method capable automatically producing proper metrics measure intra image contrast inter image consistency detecting saliency purely self learning way second problem embedded spl paradigm able alleviate data ambiguity weak supervision saliency detection guide robust learning manner complex scenarios experiments benchmark datasets together multiple extended computer vision applications demonstrate superiority proposed framework beyond state arts
objective define values normalized brain volume nbv categorized low medium high according baseline characteristics relapsing remitting multiple sclerosis rrms patients methods expected nbv enbv calculated patient based age disease duration sex baseline expanded disability status scale edss lesion volume entering variables multiple regression model run rrms patients pooled freedoms freedoms population according difference observed nbv enbv patients classified low nbv medium nbv high nbv evaluated whether nbv categories clinically meaningful assessing correlation disability worsening results distribution differences observed nbv enbv used categorize patients low nbv medium nbv high nbv taking high nbv group reference hazard ratios hrs year disability worsening adjusted treatment effect confidence interval medium nbv low nbv predictive value nbv groups preserved years treatment effect appeared evident low nbv patients medium nbv high nbv patients however difference significant conclusion rrms patients categorized disability risk groups based individual enbv values according baseline demographics clinical characteristics
paper investigates impact ethnic segregation life chances low income african american latino children focusing whether ethnic composition neighbourhood per matters correlated aspects residential environment approach links consequences segregation neighbourhood effects literatures arguing metropolitan segregation forces directly shape children intra neighbourhood ethnic exposure indirectly shape exposure non ethnic aspects neighbourhood associations wide range neighbourhood characteristics children health exposure engaging violence educational fertility outcomes quantified using natural experiment thereby permitting valid causal inferences data analysed come retrospective survey denver housing authority dha residents analysis avoids parental geographic selection bias dha assignment households neighbourhoods mimics random process logit models stratified ethnicity show growing amid concentrations african american residents associated variety adverse outcomes low income latino especially african american children though outcomes associated concentrations latino residents mixed virtually negative associations disappear however aspects residential context controlled several positive ones persist adverse developmental consequences ethnic segregation appear generated primarily denver concentrating minority children neighbourhoods higher rates property crime lower occupational prestige
paper reports work developing multi disciplinary multi institutional approach teaching ethical social safety health environmental issues nanotechnology grant nsf developing implementing assessing two modular courses include societal ethical environmental health safety issues related nanotechnology undergraduates engineering engineering technology collaborative project texas state university hispanic serving institution hsi university texas tyler tyler whose student population percent women work conducted highly interdisciplinary team faculty bring project expertise mechanical engineering manufacturing engineering civil engineering electrical engineering industrial education technology physics biology philosophy ethics explain origin project explicate developed course modules review first two semesters summer fall teaching modules examine initial results evaluations
chemotherapy induced peripheral neuropathy cipn obesity prevalent cancer survivors decrease quality life however impact occurrence conditions garnered little attention study investigated differences obese non obese cancer survivors cipn predictors symptom burden pain patients cipn administered anderson symptom inventory modified version pain descriptors mcgill pain inventory independent tests assessed group differences obese non obese survivors linear regression analyses explored predictors patient outcomes results indicated significant difference symptom severity scores obese versus non obese patients significant differences also found total number pain descriptors endorsed obese versus non obese participants obesity significant predictor symptom severity total pain descriptors endorsed significant predictors included age months since treatment cancer survivors cipn occurring obesity may risk decreased quality life increased symptom severity pain compared non obese survivors paper identified risk factors including obesity age months since treatment clinically identified monitoring distress cipn patients future research focus longitudinal relationship obesity cipn robust interventions address multifaceted issues faced cancer survivors
background consensus documents published date hereditary angioedema inhibitor deficiency inh hae focused adult patients many previous recommendations adapted pediatric patients intended produce consensus recommendations diagnosis management pediatric patients inh hae methods expert panel meeting took place inhibitor deficiency workshop budapest www haenet pediatric data presented discussed consensus developed voting results symptoms inh hae often present childhood differential diagnosis difficult abdominal pain common pediatric inh hae also commonly occurs general pediatric population early onset symptoms may predict severe subsequent course disease age year inh levels may lower adults therefore advisable confirm diagnosis age one year neonates infants affected inh hae family member screened inh deficiency pediatric patients always carry inh hae information card medicine emergency use regulatory approval status drugs prophylaxis acute treatment different country plasma derived inh recombinant inh ecallantide agents licensed acute treatment pediatric patients clinical trials underway additional drugs recommended follow patients hae comprehensive care center conclusions pediatric focused international consensus diagnosis management inh hae patients created
installation sensors networks continuous service monitoring structures efficiency conditions current research trend paramount interest line monitoring systems could strategically useful road infrastructures expected perform efficiently self diagnostic also emergency scenarios work researches damage detection composite concrete steel structures typical highway overpasses bridges techniques herein proposed assume typical damage deck occurs form delamination cracking affects peak power spectral density dynamic curvature investigation performed combining results measurements collected long gauge fiber optic strain sensors installed monitored structure statistic approach finite element model also prepared validated deepening peculiar aspects investigation availability method proposed method real time applications able detect documented unusual behavior damage deterioration long gauge fiber optic strain sensors measurements probabilistic study dynamic curvature power spectral density
introduction irrational use topical corticosteroid quite common india due unrestricted availability use general public also physicians chemists due quick relief symptoms different dermatological conditions aim present study conducted evaluate analyse prevalence misuse causes behind misuse among patients dermatology outpatient department new delhi materials methods cross sectional observational questionnaire based study conducted period months june november patients questioned assessed misuse tcs terms indication dose frequency duration source recommendation results study period patients presented inappropriate use patients attending opd dermatology unit government hospital total patients presented adverse effects resulting misuse drugs female patients years common age group affected found fungal infection common reason abuse followed facial acne lightening skin colour friends family found influencing factors misuse betamethasone commonly used preparation tinea incognito followed facial acne common side effect experienced conclusion outcome misuse could dreadful cause lies levels patients family physicians regulatory authorities
summary study explores courtroom interactions judges attorneys parents charged child abuse neglect drawing ethnographic observations court cases family court located northeastern united states study seeks understand judges encourage inhibit parents participation strategies tactics used influence parental behaviors obtain cooperation court orders findings one end spectrum judges engage little parents preferring speak professional court actors end spectrum participatory approach judges weaving parents court room exchanges engaging informational decision making dialogs similar divergence appears soliciting cooperation parents judges relying shaming rituals others using softer approach incorporates praise support applications strategic interventions identified increase parents cooperation satisfaction family court system include vigorously engaging informational decision making dialogs parents using rituals praise support rather shaming
heavy metal migration evaluated tailings covered different topsoil constructions four topsoil constructions different interlayers one direct topsoiling tailings second limestone interlayer tailings topsoil two geotextile layers set interlayer sls third lime interlayer also two geotextile layers fourth clay interlayer two geotextile layers topsoils evaluated day laboratory column leaching experiments year field cover application abandoned tailings pond northeastern china contents soils leachates interlayers leaves amotpha fruticosa analysed inductively coupled plasma optical emission spectroscopy icp oes results showed values leachates columns increased time range maximum tailings sls appeared day respectively topsoil effectively reduced concentrations leachate addition limestone lime interlayer enhanced efficiency especially concentrations topsoil directly cover tailings appreciably less initial concentrations resulting eluviation presence limestone lime interlayer reduced mobility clay interlayer effective preventing migration less impact year field experiment values topsoil increased slightly time range end experiment concentrations topsoil sls plots showed little change compared initial value acid soluble concentrations upper soil increased indicating acid soluble heavy metals migrated tailings topsoil acid soluble topsoil interlayer showed small increase plot indicating may migrate clay layer topsoil pore water contents leaves sls appreciably lower contents leaves higher sls topsoiling interlayer could reliable technique preventing toxic elements moving downward upward ecological restoration tailings ponds elsevier rights reserved
data related businesses emerging trend recent decade however availability amount information make difficult ensure quality terms data fusion version control completely automated data aggregation systems fail provide reliable consistent data paper summarise existing knowledge relation databases augment description business requirements data version control propose architecture addresses requirements discuss possible future work improve evaluate approach
background pronated foot posture associated many clinical biomechanical outcomes unique medial compartment knee osteoarthritis though shoe worn insole treatment including lateral wedges commonly studied patient population effects specific subgroup people medial knee concomitant pronated feet unknown purpose study evaluate whether lateral wedge insoles custom arch support beneficial lateral wedge insoles alone knee foot symptoms people medial tibiofemoral knee osteoarthritis pronated feet methods twenty six people pronated feet symptomatic medial knee participated randomized crossover study comparing five degree lateral wedge foot insoles without custom foot arch support intervention worn two months separated two month washout period insoles wear main outcomes included western ontario mcmaster universities osteoarthritis index womac pain physical function subscales revised short form foot function index ffi pain stiffness subscales timed stair climb test regression modeling conducted examine treatment period interaction effects results twenty two participants completed study carryover interaction effects observed outcome significant treatment effects observed timed stair climb greater improvements seen lateral wedges arch support within condition significant improvements observed womac pain physical function well ffi pain stiffness lateral wedges arch support use adverse effects reported lateral wedges alone people preferred lateral wedges arch support overall conclusions addition custom arch support standard lateral wedge insole may improve foot knee symptoms people knee concomitant pronated feet preliminary findings suggest research evaluating role shoe worn insoles treatment specific sub group people knee warranted
background micrornas mirnas class small non coding rnas strongly involved various types carcinogenesis including hepatocellular carcinoma hcc study aimed clarify whether mir promotes hcc growth targeting trim regulating pkm phosphorylation material methods online software including targetscan miranda used predict potential target mir real time pcr qrt pcr western blot assays performed detect expression levels mrna protein respectively cell proliferation measured mtt assay apoptosis cells examined flow cytometry results bioinformatics reveal trim mrna contains conserved target site mir high level mir low levels trim mrna protein observed hcc cells compared normal liver cell line biological function analysis showed mir inhibitor inhibits cell proliferation promotes apoptosis hcc cells furthermore verified trim functional target mir use luciferase reporter assay trim overexpressing showed elevation proliferation reduction apoptosis hcc cells subsequently investigated whether mir trim regulate hcc cell proliferation apoptosis pkm phosphorylation results supported speculation mir targets trim regulates phosphorylation pkm promote hepatocarcinogenesis conclusions findings indicate mir may function oncogene hcc potential alternative therapeutic target deadly disease
background depression worldwide public health problem requires attention qualified health professionals training skilled nurses challenge nursing instructors due complexity pathology objectives aim analyse declarative argumentative knowledge acquired depression students receiving traditional expository instruction versus students receiving problem based learning instruction methods quasi experimental study pre test post test design experimental control group measure differences improvement declarative argumentative knowledge non parametric tests used compare scores experimental group control group pre test post test group students participated study implementation study took place academic year third year nursing undergraduate degree courses university basque country upv ehu part mental health nursing subject results data indicated statistically significant differences two methodologies regard declarative knowledge care patients depression nevertheless argumentative capacity experimental group improved significantly problem based learning methodology conclusions results implementation indicated problem based learning satisfactory tool acquisition argumentative capacity depression nursing care still working examples teaching sequences bridge gap general clinical practice classroom practice remain important goal continuing research nursing education elsevier ltd rights reserved
paper presents novel framework called bean aims monitor evaluate enhance pre school children skills abilities playing ambient intelligence environments framework includes model children development based icf model denver assessment tool aiming early detection children potential developmental issues investigated addressed necessary reasoning mechanism automated extraction child development knowledge based interaction monitoring targeted model relevant aspects child developmental stage maturity level skills iii content editing tools reporting facilities parents therapists framework implemented context ami environment supporting children play ami deploying collection augmented artifacts well collection digital reproductions popular games
network security systems inspect packet payloads signatures attacks systems use regular expression matching core many techniques implementing regular expression matching line rate proposed solutions differ type automaton used deterministic versus non deterministic configuration implementation specific parameters solution shown perform well specific rule sets traffic patterns systematic comparison across large set solutions rule sets traffic patterns thus extremely challenging practitioner make informed decision within plethora existing algorithmic architectural proposals moreover multi core processors becoming popular many parameters need tuned maximize multi core potential address problem present comprehensive evaluation broad set regular expression matching techniques consider algorithmic architectural aspects specifically explore performance area requirements power consumption implementations targeting multi core processors fpgas using rule sets practical size complexity present detailed performance results specific guidelines determining optimal configurations based simple evaluation rule set guidelines help significantlywhen implementing regular expression matching systems practice
microstructures metallic materials become extremely refined mechanical strengths exhibit considerable anisotropy subjected severe plastic deformation equal channel angular pressing ecap small punch testing method employed substitute standard tension test assess anisotropic tensile strength materials produced ecap testing viable alternative standard tension tests ecap samples usually limited approximately length transverse direction perpendicular extrusion longitudinal direction ecap process dimensions test specimen tests performed using specimens aged aluminum alloy subjected three ecap passes degrees extracted wire cutting along longitudinal transverse axes failure surfaces specimens testing showed failure caused shear deformation ecap processed materials displayed anisotropic strength based results method proposed assess tensile strength along transverse longitudinal axes ecap materials exhibiting anisotropic strength validity proposed method verified comparison performance evaluating plastic flow strength measurements obtained tension tests along longitudinal axis elsevier rights reserved
background altered intrinsic function brain implicated borderline personality disorder bpd nonetheless imaging studies yielded inconsistent alterations brain function investigate neural activity rest bpd conducted set meta analyses brain imaging studies performed rest methods total seven functional imaging studies patients bpd control subjects combined using whole brain signed differential mapping meta analyses furthermore two conjunction meta analyses neural activity rest also performed neural activity changes emotional processing structural differences respectively results found altered neural activity regions default mode network dmn bpd within regions midline core dmn patients bpd showed greater activity anterior well posterior midline hubs relative controls conversely regions dorsal dmn showed reduced activity compared controls right lateral temporal complex bilaterally orbitofrontal cortex increased activity precuneus observed rest emotional processing reduced neural activity rest lateral temporal complex associated smaller volume area limitations heterogeneity across imaging studies conclusions altered activity regions midline core well dorsal subsystem dmn may reflect difficulties interpersonal affective regulation bpd findings suggest changes spontaneous neural activity could underlie core symptoms bpd elsevier rights reserved
meloxicam bcs class drug belonging class nsaids indicated conditions rheumatoid arthritis ankylosing spondylitis osteoarthritis rapid onset drug action desired reduce inflammation pain objective study thus develop self nanoemulsifying granules snegs meloxicam mlx enhancement solubility subsequently dissolution rate thus aiming faster onset action preliminary studies along molecular modeling studies carried selection appropriate lipids surfactants cosurfactants development mlx loaded self nanoemulsifying preconcentrate snep charge inducer incorporated formulation increase solubility mlx lipids hence drug loading three factor optimal mixture design used optimization mlx loaded snep role charge inducer increasing drug loading mlx snedds studied molecular dynamics simulation using desmond optimized snep adsorbed onto solid carriers form snegs improved stability enhanced flow properties physical characterization studies snegs vitro release studies vivo evaluation anti inflammatory activity optimized formulation performed results indicated mlx snegs promising alternative conventional oral nsaids therapy enhanced dissolution characteristics subsequent rapid onset action
analysis steam generators interface primary secondary circuits light water nuclear power plants crucial terms safety design issues vver nuclear power plants use horizontal steam generators demand detailed thermal hydraulics investigation order predict behavior normal transient operational conditions two phase flow field simulation adjacent tube bundles important obtaining logical numerical results however complexity tube bundles due geometry arrangement makes complicated employment porous media suggested simplify numerical modeling study presents use porous media simulate tube bundles within general purpose computational fluid dynamics code solved governing equations generalized phase continuity momentum energy equations boundary conditions one main challenges numerical analysis optimized model verified tuned simple two dimensional geometry shown obtained vapor volume fraction near cold hot collectors predict experimental results accurately previous studies copyright published elsevier korea llc behalf korean nuclear society
mindfulness studied extensively basic clinical settings however discussions still persist current research approached issue creating new measure trait mindfulness construct defined within end state mindfulness tendency see things moment moment without judgment newly created scale validated three studies end state mindfulness negatively correlated rumination suppression neuroticism better average effect correlated positive negative trait affectivity also moderated negative emotional reactions context mortality salience end state mindfulness differentiated past measure mindfulness many aspects elsevier ltd rights reserved
last decade number available cores increased heterogeneity grew work ask question whether design current operating systems oses still appropriate trends continue lead abundantly available heterogeneous cores whether forces fundamental rethinking systems designed argue hiding heterogeneity behind common hardware interface unifies large extent control coordination cores accelerators isolating network chip rather processor features like privileged mode memory management unit allows running untrusted code arbitrary cores providing services via protocols network onchip instead via system calls makes accessible arbitrary types cores well summary turns accelerators first class citizens enables single convenient programming environment cores without need trust application paper introduce network chip level isolation present design microkernel based common hardware interface evaluate performance prototype comparison linux bit surprising without using accelerators outperforms linux application level benchmarks factor five
consideration special application environment electronic products used aerospace improve human computer interaction manned aerospace area research based design implementation way high resolution spaceborne infrared touch screen basis fpga dsp frame structure beside introduction whole structure high resolution spaceborne infrared touch screen system essay also gives detail information design hardware high resolution spaceborne infrared touch screen system fpga design gui design dsp algorithm design based lagrange interpolation easy makes comprehensive research reliability design high resolution spaceborne infrared touch screen special purpose besides system test done installation spaceborne infrared touch screen test result shows system simple reliable enough stable running environment high resolution certainly meet special requirement manned aerospace instrument products
background incidence skin diseases children influenced hereditary social environmental factors objective study determine incidence pediatric dermatoses university hospital northern greece patients methods reviewed epidemiologic data patients aged years referred outpatient clinic university hospital january december demographic data frequency various diagnoses various age groups studied results nine hundred forty children adolescents diagnoses included study females males frequent diagnoses dermatitis eczema viral infections pigmentary disorders melanocytic nevi alopecia areata acne nail disorders vascular malformations hemangiomas psoriasis bacterial infections atopic dermatitis prevalent dermatosis age groups accounting total study population remarkably high incidence various forms mastocytosis seen data conclusion atopic dermatitis frequent pediatric dermatosis age groups viral infections pigmentary disorders nevi account significant proportion referrals high incidence mastocytosis study may attributed overdiagnosis overestimation due relatively small study population may represent real incidence mastocytosis region low incidence acne study may attributed fact severe cases referred hospital
background biological underpinnings serious violent behaviors patients schizophrenia remain unclear aim study identify characteristics brain morphometry patients schizophrenia history serious violent acts treated relatively new legislation offenders mental illness japan relevant action strongly associated mental illness also investigated whether morphometric changes would depend types serious violent actions methods thirty four male patients schizophrenia hospitalized committing serious violent acts compared male outpatients inpatients schizophrenia history violent acts weighted magnetic resonance imaging mri voxel based morphometry used assess gray matter volume additionally patients violent acts divided based whether relevant actions premeditated regional volumes two groups compared control patient group results patients schizophrenia history serious violent acts showed significantly smaller regional volumes right inferior temporal area expanded middle temporal gyrus temporal pole right insular area compared patients without history violence patients premeditated violent acts showed significantly smaller regional volumes right inferior temporal area right insular area left planum polare area including insula bilateral precuneus area including posterior cingulate gyrus without history violence whereas patients impulsive violent acts showed significantly smaller volumes right inferior temporal area compared without history violence conclusions patients schizophrenia history serious violent acts showed structural differences brain regions compared schizophrenia history violence abnormalities right inferior temporal area relatively common depend whether violent actions premeditated abnormalities wider range may attributed planning violent action others also maintaining plan
purpose present review provide comprehensive picture efficacy different tumor necrosis factor tnf alpha inhibiting agents treatment acute anterior uveitis aau common extra articular manifestation ankylosing spondylitis related aau may lead severe visual impairment due frequent flare recurrences anterior posterior segment complications traditional treatment side effects considerably higher levels tumor necrosis factor tnf assessed aqueous humor inflamed joints patients anti tnf drugs shown efficacy preventing relapses rheumatological manifestations spondyloarthropathies several studies underlined sustained efficacy monoclonal anti tnf antibodies also reducing recurrence anterior chamber flares patients related aau hand retrospective studies observational reports indicated lower effectiveness paradoxical occurrence uveitis following treatment soluble receptor agent etanercept growing evidence suggests prophylactic strategy could advocated subjects frequent recalcitrant attacks aau regard administration monoclonal anti tnf antibodies adalimumab ada shown significantly reduce rate aau recurrences indeed ada treatment patients shown remain completely free attacks entire follow period studies studies needed confirm long term efficacy tnf inhibitors related aau also role preventing ocular complications visual impairment
may june equipped eight subadult male yrs old grizzly bears ursus arctos satellite radio collars within study area centred northeast yellowknife northwest territories canada subadult male annual home ranges extraordinarily large average due part movement occasional linear directionality believe long range linear movements may reflect individuals tracking migration caribou rangifer tarandus seasonal daily movement patterns similar adult males previously reported areas used bears largest ranges reported grizzly bears scale movements may put individual bears contact humans even developments hundreds kilometres central home range animal
objectives examine treatment patterns treatment effectiveness treatment costs year patients rheumatoid arthritis switched tumor necrosis factor inhibitor tnfi adalimumab certolizumab pegol etanercept golimumab infliximab either cycling another tnfi tnfi cyclers switching new mechanism action abatacept tocilizumab tofacitinib new moa switchers methods retrospective cohort study used administrative claims data national insurer treatment persistence without switching restarting discontinuing treatment effectiveness defined costs assessed month post switch period patients effectively treated satisfied six criteria treatment effectiveness algorithm high adherence dose increase new conventional synthetic disease modifying anti rheumatic drug subsequent switch therapy new increased oral glucocorticoids glucocorticoid injections multivariable logistic models used adjust baseline factors results database included new moa switchers tnfi cyclers new moa switchers likely tnfi cyclers persist switch odds ratio confidence interval less likely switch therapy new moa switchers likely tnfi cyclers effectively treated new moa switchers lower drug costs tnfi cyclers cost ratio lower total costs rheumatoid arthritis related medical care cost ratio limitations claims payments may reflect rebates cost offsets medical pharmacy claims include clinical end points reasons lead new moa switching tnfi cycling conclusions results support switching new moa patient fails treatment tnfi consistent recent guidelines pharmacologic management established rheumatoid arthritis
depth ordering two surfaces one occluding principle determined correlation occlusion border blur blur two surfaces border blurred blurrier surface nearer border sharp sharper surface nearer previous research found observers use informative cue reexamined finding using multiplane display confirmed previous finding observers accurately judge depth order blur rendered stimulus presented one plane presented simulated scenes multiple planes different focal distance blur created optics eye performance much better shows depth order reliably determined blur information optical effects similar natural viewing asked critical differences single multiplane cases found chromatic aberration provides useful information accommodative microfluctuations addition examined image formation affected occlusions observed interesting phenomena allow eye see around occluding objects may allow observers estimate depth vinci stereopsis one eye view blocked finally evaluated accurately different rendering displaying techniques reproduce retinal images occur real occlusions discuss implications computer graphics
background impulsivity core feature borderline personality disorder bpd attention deficit hyperactivity disorder adhd bpd impulsive behavior primarily occurs acute stress impulse control deficits non stress conditions may partly related morbid adhd aimed investigate whether acute experimental stress impact self reported impulsivity response inhibition action withholding action cancelation delay discounting bpd compared adhd method thirty female bpd patients female adhd patients excluding patients morbid bpd adhd female healthy controls completed self reports behavioral measures impulsivity imt assessing action withholding gostop measuring action cancelation delay discounting task baseline conditions experimental stress induction mannheim multicomponent stress test results patient groups reported higher impulsivity adhd reported higher trait impulsivity bpd imt adhd showed significant action withholding deficits conditions bpd performed significantly worse stress bpd adhd action withholding deficits imt significantly increased stress compared baseline group stress effects found action cancelation gostop delay discounting significantly pronounced bpd stress effect found conclusions bpd behavioral deficits action withholding action cancelation appear influenced acute experimental stress delay discounting seems general feature bpd independent morbid adhd acute stress possibly underlying typical expressions behavioral impulsivity disorder
order attain emissions reduction targets improve air quality reduce global warming electric vehicles evs arise alternatives conventional vehicles fueled fossil fuels context work presents comparative study conventional version medium duty diesel engine powered vehicle road tests following standard cycle urban driving conditions performance parameters evaluated electric energy consumption carbon dioxide emissions electricity generation conventional vehicle exhaust emissions energy consumption calculated fuel consumption heating value five scenarios built conduct economic viability study terms payback net present value npv considering conditions applied results environmental analysis showed emissions times lower comparison diesel vehicle hand economic analysis revealed viability compromised mainly due imported parts unfavorably high exchange rates best scenario considering revenue commercial application calculated payback period years operation elsevier ltd rights reserved
background mobile health mhealth apps shown improve health indicators concerns remain inclusion populations low medium income countries lmic new technologies atrial fibrillation chronic condition challenging management previous studies shown socioeconomic differences prescription anticoagulant treatment shared decision strategies encouraged achieve better outcomes mhealth aid doctors patients matter objective describe development mhealth app afib idealized aid shared decision doctor patient anticoagulation prophylaxis low income low literacy population brazil basis research suggest processes followed developing mhealth apps context methods multidisciplinary team collected information target population needs detected best opportunity insert app current health care literature subject reviewed important data selected delivered good navigability easy terminology friendly design app evaluated multimethod setting results steps suggested develop mhealth app target lmic characterize problem target user review literature translate information knowledge protect information evaluate usability efficacy conclusions expect recommendations guide development new mhealth apps lmic scientific basis
background altered physical activity important feature depression manifested psychomotor retardation agitation withdrawal engagement normal activities modern devices activity monitoring actigraphs make possible monitor physical activity unobtrusively validity actigraphy indicator mood state uncertain carried systematic review digital actigraphy patients depression investigate associations measured physical activity depression methods systematic review meta analysis studies identified medline embase psycinfo databases included either case control longitudinal studies actigraphy adults aged diagnosed depressive disorder outcomes daytime night time activity actigraphic measures sleep results identified eligible papers studies patients case control studies showed less daytime activity patients depression standardised mean difference confidence intervals longitudinal studies showed moderate increase daytime activity reduction night time activity course treatment limitations study participants unblinded seven papers included patients treated community conclusions actigraphy potentially valuable source additional information patients depression however clear guidelines use actigraphy studies patients depression studies investigate patients treated community additional work develop algorithms differentiating behaviour patterns also needed elsevier rights reserved
rapidly developing next generation sequencing technologies produce huge amounts short reads consisting randomly fragmented dna base pair strings assembling short reads poses challenge mapping reads reference genome terms sensitivity execution time paper propose customized many core hardware acceleration platform short read mapping problems based hash index method processing core highly customized suite hit string matching banded smith waterman sequence alignment operations distributed memory interface stacked architecture provides high bandwidth low access latency highly customized dataset partitioning memory access scheduling conformal original bfast program design provides amazingly times speedup software approach single end short reads times paired end short reads also beats similar single fpga solution times case single end reads optimized seed generation gives much better sensitivity performance boost still impressive
introduction ankylosing spondylitis chronic immune mediated disease affecting sacroiliac joints spine manifesting new bone formation osteopenia past decade tumour necrosis factor alpha tnf inhibitors tnfi become cornerstone therapy improving functional outcomes decreasing disease activity patients marginal benefit non steroidal anti inflammatory nsaid therapy time remains determined whether agents decrease new bone formation although studies recently suggested areas covered review discuss factors favour good response agents initially maintenance recent studies outlining strategies dose reduction expert commentary finally discuss importance using objective tools disease activity magnetic resonance imaging complementary tool clinical assessments predicting responses treatment also selecting patients suited targeted therapy
paper hopf bifurcation new hyperchaotic system studied based first lyapunov coefficient theory symbolic computation conditions supercritical subcritical bifurcation new hyperchaotic system obtained numerical simulations used illustrate main results
emergency contraception prevent pregnancy days unprotected sex although become increasingly available little known perceptions young adults regarding access whether information sources relate perceived access among young adults week period november self report survey administered college students women student union large public university southeastern united states survey assessed three aspects perceived access information sources prior use twenty one percent participants used participants reported relatively high perceptions access females reporting higher perceptions access males prior study students never heard remaining students heard average four sources among women hearing media interpersonal health education sources significantly associated greater perceived access future awareness efforts women leverage three sources future research examine specific sources focus content quality frequency messages
since many researchers attempted use changes natural frequencies means condition assessment large civil engineering structures bridges faced challenge decoupling frequency variations apparently caused changing operational conditions case tamar bridge southwest england time series natural frequencies exhibit diurnal variations resulting combination thermal vehicular loading effects would need compensated dynamics based assessment examining monitored data several years effects traffic mass characterised compared operational effects temperature changes appear greater influence lateral modes traffic mass strong factor modes dominant factor vertical torsional modes evaluated physics based explanations variable effects vehicle mass sought using finite element model calibrated experimental data caution performance prediction structural dynamics acceptable reconciliation natural frequencies model measurements achievable reconciling simulated effects changing mass observed behaviour straightforward due complexity retrofitted suspension bridge structure studied
aim study evaluate efficiency passive point use treatment system namely polyvinyl alcohol pva nanofiber membrane activated carbon column treatment harvested rainwater efficiency smi quaternized poly styrene maleimide nanofiber membrane disks placed filtration assembly treatment surface water plankenburg river western cape south africa harvested rainwater also assessed two rainwater harvesting tanks installed welgevallen experimental farm stellenbosch south africa filtration system intermittently attached tanks collection rainwater samples throughout study period parameters used monitor filtration systems included heterotrophic bacteria escherichia coli total coliform enumeration presence absence adenovirus compared drinking water guidelines results indicated potable water could produced synthesized pva nanofiber membrane activated carbon column however pcr assays indicated adenovirus numerous bacteria klebsiella spp legionella spp pseudomonas spp yersinia spp effectively removed filtration system utilized additionally smi nanofiber membrane disks remove viruses river tank water samples bovine adenovirus strain simian adenovirus human adenovirus strain detected water samples analyzed thus microfiltration system efficient reducing level indicator organisms within drinking water standards optimization electrospun filtration membranes required molecular analysis revealed numerous opportunistic bacterial pathogens viruses persisted filtration
lock free concurrent algorithms guarantee concurrent operation always make progress finite number steps yet programmers prefer treat concurrent code wait free guaranteeing operations always make progress unfortunately designing wait free algorithms generally complex task resulting algorithms always efficient although obtaining efficient wait free algorithms long time goal theory community nonblocking commercial code lock free article suggests simple solution problem show large class lock free algorithms scheduling conditions approximate found commercial hardware architectures lock free algorithms behave wait free words programmers continue design simple lock free algorithms instead complex wait free ones practice get wait free progress main contribution new way analyzing general class lock free algorithms stochastic scheduler analysis relates individual performance processes global performance system using markov chain lifting complex per process chain simpler system progress chain show lock free algorithms wait free probability fact general subset lock free algorithms closely bounded terms average number steps required operation completes best knowledge first attempt analyze progress conditions typically stated relation worst case adversary stochastic model capturing expected asymptotic behavior
facial images embed age gender rich information implicitly related occupation work advocate occupation prediction single facial image doable computer vision problem extract multilevel hand crafted features associated locality constrained linear coding convolutional neural network features image occupation descriptors avoid curse dimensionality fitting boost strategy called multichannel svm used integrate features face body intra interclass visual variations jointly considered boosting framework improve performance evaluation verify effectiveness predicting occupation face demonstrate promising performance obtained combining face body information importantly work integrates deep features multichannel svm framework shows significantly better performance state art
ignition cloud dry powder major concern field industrial process safety different types discharges already defined spark discharges brush discharges propagating discharges cone discharges corona discharges ignition properties gas dust atmosphere example known classic brush discharge ignite cloud dry flammable dust glor schwenzfeuer performed direct ignition tests using brush discharges defined even energy released kind discharge equaled one spark power released brush discharge low trigger ignition however doubts remained super brush discharges brush discharge super brush discharge occurs charged insulating object conductive electrode main difference lies surface charge density reached insulator much higher super brush discharge brush discharge high charge density reached example using pipes polyethylene individually charged tribo charging piled one another configuration evocated liittgens tested larsen performed direct ignition tests oxygen enriched atmospheres study relevant actual safety problems since pharmaceutical chemical powders well known generate electrostatic charges transport handling since configuration independent polyethylene fibers found flexible bulk containers one common solutions package kind powder paper presents experimental set results direct ignition tests performed polyethylene wax whose mie lower ambient conditions electric field reached charge transfer also registered described finally numerical simulations carried define original surface charge density order help understand phenomenology discharge frequency occurrence industry elsevier rights reserved
load demand forecasting critical process planning electric utilities ensemble method composed empirical mode decomposition emd algorithm deep learning approach presented work purpose load demand series first decomposed several intrinsic mode functions imfs deep belief network dbn including two restricted boltzmann machines rbms used model extracted imfs tendencies imfs accurately predicted finally prediction results imfs combined either unbiased weighted summation obtain aggregated output load demand electricity load demand data sets australian energy market operator aemo used test effectiveness proposed emd based dbn approach simulation results demonstrated attractiveness proposed method compared nine forecasting methods elsevier rights reserved
backgroundthis study explored psychological adjustment sibling relationships siblings children life limiting conditions llcs expanding previous research defining llcs using systematic classification conditions methodsthirty nine siblings participated aged years parents completed measures siblings emotional behavioural difficulties quality life sibling relationships impact families siblings sibling family adjustment relationships compared population norms available matched comparison group siblings children autistic spectrum disorder asd comparable high risk group resultsllc siblings presented significantly higher levels emotional behavioural difficulties lower quality life population norms difficulties levels comparable siblings children asd wider impact family confirmed family socio economic position time since diagnosis employment accessing hospice care factors associated better psychological adjustment conclusionsusing systematic classification llcs study supported earlier findings increased levels psychological difficulties siblings children llc evidence highlighting need provide support siblings families intervention approaches could drawn asd field
china currently world largest emitter carbon dioxide considered large agricultural country carbon emission china agriculture sector keeps growing rapidly therefore great importance investigate driving forces carbon dioxide emissions sector traditional regression estimation get average global parameter estimates excludes local parameter estimates vary across space spatial systems geographically weighted regression embeds latitude longitude sample data regression parameters uses local weighted least squares method estimate parameters point point reveal nonstationary spatial effects driving forces geographically weighted regression model employed paper results show economic growth positively correlated emissions impact western region less central eastern regions urbanization positively related emissions produces opposite effects pattern energy intensity also correlated emissions decreasing trend eastern region central western regions therefore policymakers take full account spatial nonstationarity driving forces designing emission reduction policies
objectives explore relationships nigrostriatal dysfunction neuropsychiatric symptoms including anxiety depression apathy large cohort newly diagnosed drug naive parkinson disease patients compared cohort healthy controls methods cross sectional analysis parkinson progression markers initiative ppmi cohort baseline including patients nigrostriatal degeneration evaluated means spect dat scan relationships neuropsychiatric symptoms dat uptakes analysed means stepwise multiple regression analysis results group lower dat uptake right caudate associated higher stai trait subscore beta depression apathy scores related dat uptakes associations found group conclusions cross sectional analysis ppmi data shows lower caudate dat uptake associated higher level anxiety data strengthens relationship dopaminergic dysfunction neuropsychiatric symptoms early elsevier ltd rights reserved
motor planning monolithic process distinct stages motor planning responsible encoding different levels abstractness however distinct components mapped different neural substrates remains open question studied one high level motor planning components defined second order motor planning patient extremely rare case cerebellar agenesis without cortical malformations second order motor planning dictates two acts must performed sequentially planning second act influence execution first used optoelectronic system kinematic analysis compare performance age matched controls secondorder motor planning task first act reach object second place small large container results showed despite expected difficulties fine motor skills second order motor planning ability modulate first act function nature second act preserved even patient congenital absence cerebellum results open new intriguing speculations role cerebellum motor planning abilities although prudence imperative suggesting conclusions made basis single case findings evidence suggests fascinating hypotheses neural circuits support distinct stages motor planning hierarchy regarding functional role second order motor planning motor cognition potential dysfunction autism new noteworthy traditionally cerebellum considered essential motor planning studying extremely rare patient cerebellar agenesis group neurotypical controls found high stages motor planning hierarchy preserved even patient congenital absence cerebellum results provide interesting insights shed light neural circuits supporting distinct levels motor planning furthermore results intriguing potential clinical implications autism
impairment executive function core feature schizophrenia preclinical studies indicate injections either methyl aspartate nmda dopamine receptor blockers impair executive function despite prevailing notion based postmortem findings schizophrenia cortical areas marked suppression glutamate dopamine recent vivo imaging studies suggest abnormalities neurotransmitters living patients may quite subtle thus hypothesized modest impairments glutamate dopamine function act synergistically cause executive dysfunction present study investigated effect combined administration behaviorally sub effective doses nmda dopamine receptor antagonists executive function operant conditioning based set shifting task used assess behavioral flexibility rats systemically injected nmda dopamine receptor antagonists individually combination prior task performance separate injections nmda receptor antagonist dopamine receptor antagonist sch low doses impair set shifting however combined administration behaviorally sub effective doses antagonists significantly impaired performance set shifting without affecting learning retrieval memory initial rule latency responses number omissions combined treatment also produced increased number perseverative errors results indicate nmda receptor blockade act synergistically cause behavioral inflexibility subtle abnormalities glutamatergic dopaminergic systems may act cooperatively cause deficits executive function elsevier rights reserved
cognitive impairments uncontrolled drinking neuropathological cortical changes characterize alcohol use disorder dysfunction orbitofrontal cortex ofc critical cortical subregion controls learning decision making prediction reward outcomes contributes executive cognitive function deficits alcoholic individuals electrophysiological quantitative synaptomics techniques used test hypothesis heavy drinking produces neuroadaptations macaque ofc integrative bioinformatics reverse genetic approaches used identify validate synaptic proteins novel links heavy drinking bxd mice drinking monkeys evoked firing ofc pyramidal neurons reduced whereas amplitude frequency postsynaptic currents enhanced compared controls bath application alcohol reduced evoked firing neurons control monkeys drinking monkeys profiling ofc synaptome identified alcohol sensitive proteins control glutamate release sva synaptogyrin postsynaptic signaling glua prrt changes synaptic gabaergic proteins western blot analysis confirmed increase glua expression drinking monkeys exploratory analysis ofc synaptome found cross species genetic links alcohol intake discrete proteins ccdl diras discriminated low heavy drinking monkeys validation studies revealed bxd mouse strains allele ccdl interval drank less alcohol allele strains thus profiling ofc synaptome identified changes proteins controlling glutamate release postsynaptic signaling discovered several proteins related heavy drinking potential novel targets treating alcohol use disorder
article presents progress major research whose objective analyze relationships participation women rural areas associative economic productive initiatives potential empowerment processes intercultural contexts specifically work explores processes subordination awareness transformation gender roles construction positioning social actors participants economic productive associations araucania region following constructionist grounded theory perspective ten notes participant observations workshop discussion implemented women associated develop kind enterprises conclusions show empowerment women rural areas process multiple paradoxical moments empowerment disempowerment coexist occur one another overlap
bipolar disorder characterized manicdepressive psychiatric syndrome life threatening risks patient diagnosed individuals undergo long term lithium therapy proven effective mood stabilization maintaining blood lithium concentration levels within narrow therapeutic window vital patient slightly elevated concentrations order mmcan toxic paper aims evaluate merits tetrapolar electrical impedance spectroscopy alternative method monitoring blood lithium levels measurements performed using custom made tetrapolar probe human blood plasma lithium concentrations covering therapeutic range results indicate limit detection less response time less prediction lithium concentration levels using impedance values good agreement conventional standard techniques approximately technique provides basis development instrumentation point care healthcare technologies
colombia several communities limited uncertain access drinking water services collect rainwater various domestic uses paper presents results water quality analysis rainwater runoff roofs kennedy bogota evaluate suitability adapting water satisfy domestic uses district based high values turbidity biochemical oxygen demand high concentrations total suspended solids heavy metals found studied rainwater concluded water samples suitable domestic uses currently employed citizenry nevertheless high spatial temporal variability detected addition variability function roof material particular cases runoff water roofs may adapted alternative source domestic uses district
reform public organizations vital improvement public services public trust primary aim research investigate role ambidextrous leadership catalysing organizational reform research seeks insight moderating mechanisms effect research employed two wave research design collect data employees department managers working governmental agencies vietnam context results data analysis shed light effect ambidextrous leadership organizational reform well mechanisms employees role breadth self efficacy public service motivation moderate effect
helicobacter pylori pylori gram negative motile bacterium colonizes hostile microniche human stomach persists host entire life effectively treated clinically pylori plays causative role development wide spectrum diseases including chronic active gastritis peptic ulceration gastric adenocarcinoma gastric mucosa associated lymphoid tissue lymphoma due global distribution pylori exaggeration conclude smart strategies contributing adaptation bacterium permanent host thirty four years discovery bacterium still many unanswered questions example strategies help bacterium survive inhospitable microniche question slightly easier answer presume clinical concept persistent infection disease understanding mechanisms governing pylori persistence improve identification increased risk diseases gastric cancer patients infected bacterium well defined long term equilibrium human host pylori allows bacterial persistence gastric microniche although coexistence leads high risk severe diseases gastric cancer escape bactericidal activity stomach acid pylori secretes large amounts surface associated cytosolic urease potential avoid acidic conditions immune evasion discussed order explain persistence pylori colonization gastric mucosa data bacterial genetic diversity included information mechanisms related pylori persistence also provide direction future research concerning effective therapy management gastroduodenal disorders topics presented current review important elucidating strategies used pylori help bacterium persist relation immune system many unfavorable features living gastric microniche
simple access interfaces flexible billing models cloud storage become attractive solution simplify storage management enterprises individual users however traditional file systems extensive optimizations local disk based storage backend fully exploit inherent features cloud obtain desirable performance paper present design implementation evaluation coral cloud based file system strikes balance performance monetary cost unlike previous studies treat cloud storage normal backend existing networked file systems coral designed address several key issues optimizing cloud based file systems data layout block management billing model carefully designed data structures algorithms identifying semantically correlated data blocks tree based caching policy self adaptive thrashing prevention effective data layout optimal garbage collection coral achieves good performance cost savings various workloads demonstrated extensive evaluations
many patients atopic syndrome complain symptoms related irritable bowel syndrome ibs well symptoms caused asthmatic condition rhinitis well known patients well defined therapeutic strategies handle cases well known patients cause symptoms ibs unclear many patients undergo many diagnostic procedures including invasive investigations quality life qol reduced patients suffer lot psychic disorders like depression anxiety may occur end odyssey food allergies tested patients pay laboratory tests specific igg antibodies alternatively basophile activation tests bat food incompatibilities offered online platforms article causes ibs mast cell activation necessarily food allergies discussed mast cell activation lead lactose fructose histamine intolerance similarities asthma ibs similar therapeutic approach feasible
paper topology design lightweight ultra broadband polarization independent frequency selective surface absorber proposed absorption wide frequency range ghz reflection achieved optimizing topology dimensions resistive frequency selective surface virtue genetic algorithm ultra broadband absorption kept incident angle less degrees independent incident wave polarization experimental results agree well numerical simulations density ultra broadband absorber thus may find potential applications microwave engineering electromagnetic interference stealth technology
warnings memory errors reduce incidence although past work largely focused associative memory errors current study sought explore whether warnings could tailored specifically reduce false recall categorical information younger older populations encoding word pairs designed induce categorical false memories half younger older participants warned avoid committing types memory errors older adults received warning committed fewer categorical memory errors well types semantic memory errors receive warning contrast young adults memory errors differ warning versus warning groups findings provide evidence effectiveness warnings reducing categorical memory errors older adults perhaps supporting source monitoring reduction reliance gist traces effective metacognitive strategies
concurrent global economic development last years opportunities spread existing diseases emergence new infectious pathogens increased substantially activities associated enormously intensified global connectivity resulted large amounts data generated turn provides opportunities generating knowledge allow effective management animal human health risks called big data recently accompanied internet things highlights increasing presence wide range sensors interconnected via internet analysis data needs exploit complexity accommodate variation data quality take advantage spatial temporal dimensions available apart development hardware technologies networking communication infrastructure necessary develop appropriate data management tools make data accessible analysis includes relational databases geographical information systems recently cloud based data storage hadoop distributed file systems development analytical methodologies quite caught data deluge important advances made number areas including spatial temporal data analysis spectrum analytical methods ranges visualisation exploratory analysis modelling used primary focus statistical science terms methodological development data analysis newly emerged discipline data science reflection challenges presented need integrate diverse data sources exploit using novel data knowledge driven modelling methods simultaneously recognising value quantitative well qualitative analytical approaches machine learning regression methods robust handle large datasets faster classical regression approaches also used analyse spatial spatio temporal data multi criteria decision analysis methods gained greater acceptance due part need increasingly combine data diverse sources including published scientific information expert opinion attempt fill important knowledge gaps opportunities effective prevention detection control animal health threats arising developments immense without risks given different types much higher frequency biases associated data elsevier rights reserved
biography highlights historical importance ferdinand redtenbacher evolution mechanical engineering technical science century presentation substantially follows regard personal biographical details ferdinand redtenbacher essays contemporary witnesses much see well historical appraisals starts description life covering childhood early teens home upper austria culmination professional career professor director polytechnic school karlsruhe germany today university karlsruhe particular interest question external circumstances characters helped establish path redtenbacher lifework influence pushed german manufacturing engineering century even today finally paper explores redtenbacher contributions mechanism machine science means construction kinematic models teaching elsevier ltd rights reserved
background atrial fibrillation substantial genetic basis identification individuals greatest risk could minimize incidence cardioembolic stroke methods determine whether genetic data stratify risk development examined associations genetic risk scores incident prospective studies comprising individuals european ancestry examined associations genetic risk scores ischemic stroke separate study ischemic stroke cases cardioembolic referents scores based common variants associated values ranging prior independent genetic association study results incident occurred individuals genetic risk scores associated new onset adjustment clinical risk factors pooled hazard ratio incident highest versus lowest quartile genetic risk scores ranged variants confidence interval variants confidence interval discrimination combined clinical genetic risk scores varied across studies scores maximum statistic maximum delta statistic clinical score alone genetic risk associated stroke age sex adjusted models example individuals highest versus lowest quartile variant score fold increased odds cardioembolic stroke confidence interval effect persisted exclusion individuals known odds ratio confidence interval conclusions comprehensive genetic risk scores associated incident beyond associations clinical risk factors offered small improvements discrimination genetic risk also associated cardioembolic stroke age sex adjusted analyses efforts warranted determine whether genetic risk may improve identification subclinical help distinguish stroke mechanisms
introduction adaptive immunity intestinal inflammation may play key role pathogenesis crohn disease particular interleukin may key mediator chronic intestinal inflammation inducing differentiation naive cells production several pro inflammatory cytokines furthermore induces interferon ifn production activated cells critical cytokine innate adaptive immunity infections areas covered aim review available data literature regarding role specific focus recent progresses therapeutic modulation cytokine expert commentary increased knowledge regarding role allowed development effective therapeutic progresses blocking mediated pathways primary secondary loss response anti tnf therapies crohn disease patients first year widely described literature development new drugs alternative mechanisms action thus key point consider optimal management subjects drugs blocking pathway showed good efficacy safety profile immune mediated diseases studies necessary regarding role single blockade
brushless doubly fed induction generator bdfig one upcoming machines research study used offshore windfarms many advantages conventional machines electromagnetism study electric magnetic fields plays vital role design machines electric machines used novel applications around world driven need greater power efficiency transportation aerospace defense industrial automation areas difficult design machine meet performance criteria ansys maxwell software powerful tool analyze relevant performance indices related machine design finite element method used software accurate analysis modeled machine paper design brushless doubly fed induction generator bdfig pole configuration pole configuration done analysis configurations carried using ansys maxwell software authors published elsevier ltd
present work applied new control strategy power systems based technique classifying areas electrical network generators lines etc taking account margins variations variables given state secondly impact various faults weighted probability occurrence indeed technique designated fuzzy biclustering established reference database character matrix lines established events evi weighted probabilities columns state variables selected delta total load angle
objective investigate association estradiol therapy incidence breast cancer taking consideration different types combined progestogen duration exposure type regimen method systematic review meta analysis result total studies included study estradiol therapy analysis meta analysis resulted pooled rcts pooled observational studies however analysis estradiol progestogen therapy risk breast cancer varies according type progestogen duration five years presented higher risk using less five years conclusions estradiol therapy carries risk breast cancer breast cancer risk varies according type progestogen estradiol therapy combined medroxyprogesterone norethisterone levonorgestrel related increased risk breast cancer estradiol therapy combined dydrogesterone progesterone carries risk breast cancer risk rise progressively prolonged use furthermore comparing sequential therapy continuous therapy carries higher risk
pilot project conducted examine health status possible adverse health effects associated seawater exposure microbial water quality indicators phytoplankton abundance toxins surfers monterey bay central california coastal waters forty eight surfers enrolled study completed initial health background survey weekly health surveys online using survey monkey descriptive statistics generalized estimating equation regression technique used identify longitudinal correlated results surfers predominately caucasian male physically active surfed approximately week average age years data indicated surfers generally healthy low prevalence diabetes high cholesterol hypertension common health problems allergies asthma study surfers reported gastrointestinal symptoms reported upper respiratory symptoms study suggests surfers significantly likely report upper respiratory symptoms history allergies housemates upper respiratory symptoms history previous adverse health symptoms surfing red tide event often associated presence phytoplankton toxins additionally female surfers reported upper respiratory symptoms males
numerical mathematics knowledge elementary computer algorithms essential parts engineering education university provided access computer programming languages computer algebra systems installation students home computer often turned challenge solving installation problems required essential time freshmen course overcome problems university stuttgart developed online web based programming tool viplab allows hosting manifold computer programming systems matlab providing simple online development environment students past programming lab based scorm modules following conventions defined project however scorm couple limitations overall weak integration requires needlessly complicated workflow lecturers creating exercises students handing homework solutions work describe limitations overcome solution specific learning management system lms used university stuttgart
computer programming courses compulsory course many universities learning course helpful cultivate students ability analytical thinking dealing issues promote formation logical thinking rigorous scientific attitude promote innovative development disciplines effective use information technology long time computer programming courses generally considered difficult courses understand study present colleges universities exploring task driven method teaching computer science application medical universities task combined mastery teaching learning research program design course greatly increase students interest professionalism also contribute innovation course reforms study courses program design medical professional conduct industry research members research understanding industry process think computer programming ideas help students use learning resources actively carry study effectively
year old boy referred nephrologist daytime urinary incontinence suspicion overactive bladder age months referred pediatric endocrinologist polyuria polydipsia order exclude diabetes insipidus repeated water deprivation tests magnetic resonance imaging scan brain normal diabetes insipidus excluded primary polydipsia thought likely since diabetes mellitus also excluded current presentation drank day quite often wet diapers also seemed pass stools infrequently difficulty curiously grandmother similar symptoms polyuria polydipsia since childhood diagnosed primary polydipsia physical examination pediatric patient normal differential diagnosis included diabetes insipidus also contemplated possibilities nephronophthisis tubulopathies hypercalciuria laboratory results including urinalysis ultrasound kidney show abnormalities making tubulopathy hypercalciuria unlikely desmopressin test intravenous route came back completely normal pointing another cause diabetes insipidus genetic testing nephronophthisis came back negative positive missense mutation avpr gene argcys associated partial nephrogenic diabetes insipidus started daily desmopressin within days urinary incontinence resolved polyuria faecal incontinence grandmother referred geneticist eventually adult nephrologist case highlights importance thorough confronted difficult diagnosis also emphasizes test result necessarily equate presence absence condition since test sensitivity specificity yet discovered
aims determine frequency timing patterns endocrine therapy switching australian practice postmenopausal women primary breast cancer methods identified postmenopausal women population based cohort commencing endocrine therapy invasive primary breast cancer december december individual level administrative health records self report data used determine women demographic clinical characteristics including preexisting newly treated comorbidities switches endocrine therapy time therapy switching calculated chi square tests compared characteristics women switch switching within years years commencing therapy results twenty eight percent women switched initial endocrine therapy commonly tamoxifen anastrozole converse small number anastrozole exemestane letrozole exemestane switches observed women switched therapies newly treated comorbidities women switched completing years therapy women significantly likely preexisting antidepressant use women switching later remained subsequent therapy less time months years conclusions approximately one quarter postmenopausal women primary breast cancer switched endocrine therapies findings suggest majority switching australian practice planned occurring years precipitated comorbidity sequence supported trial evidence early switching however associated preexisting depression appeared marker poor persistence
creating socially conscious educational environment imperative health care practitioners significant impact health inequities effects practitioner bias prejudice discrimination health health outcomes well documented literature individuals trained provide health care entering increasingly diverse world must equipped appropriate knowledge skills order meet needs seeking care cultural competency training medical education evolved past years since institute medicine report unequal treatment confronting racial ethnic disparities health care research effectiveness training emerged several authors called integration antiracism training cultural competency curriculum found effective ways article describes approach one midwifery program order inform clinical education programs across spectrum health care practitioners
trichloroethylene tce solvents found groundwater contaminants industrial complexes pump andtreat pat systems commonly selected remediation disadvantages long operation time high cost reduce remediation time cost pat systems cost effective optimal design obtained simulation optimization model modflow mtdms used simulating groundwater flow contaminant transport genetic algorithm used optimization parallel computing technique used faster optimization cost effective optimal design achieved using two objective functions calculated total remediation cost means installation operational maintenance costs based restrictions study area two remediation scenarios examined scenario involved removal tce scenario involved containment tce within compliance line total remediation costs scenario scenario remediation time decreased years scenario years scenario sensitivity analysis determined effects installation operational maintenance costs total remediation cost showing optimal total cost remediation time affected operational cost parallel computing technique using networked slave processes increased optimization speed times however efficiency parallel computing technique decreased networking time increased
ambient intelligence ami systems collections interconnected services use heterogeneous devices integrate smoothly everyday environment users engineering systems challenging task designers need deal issues information management users profiles activities privacy distribution continuous availability application multi agent paradigm develop systems one active lines research area abstractions intentional social agents useful analyze ami systems integrated view people services working moreover paradigm already offers solutions deal many key aspects ami special issue highlights state art works line presents contributions regarding agent oriented architectures development processes ami well illustrative industrial systems built approach
context software engineering multidisciplinary dynamic nature makes challenging design educational material guide software engineering body knowledge swebok evolved become iso iec standard identified various knowledge areas part curricula although number studies address gap curricula software industry literature lacks defining process leveraged continuously improving curricula fulfill software development market demands objective paper propose software engineering curricula development evaluation process secdep takes advantage swebok guidelines improve quality programs based objective subjective evidences method process consists multi steps local software market needs target program objectives constraints taken consideration case study follow process investigate core courses delivered part curricula set universities region results conducted case study identifies factors might contribute mitigating skills shortages target software market demonstrate effectiveness process identifying weaknesses studied curricula presenting recommendations align studied curricula demands target software market assists educators design evaluation curricula conclusion based obtained results studied curricula enhanced incorporating latest technologies covering swebok knowledge areas adopting curricula standards increasing level industrial involvement curricula believe achieving enhancements educators positive impact curricula question elsevier rights reserved
purpose paper explore private university engineering master service state special needs talent training project improve practical ability engineering master solve practical problems enterprises practical problem faced pilot colleges universities paper discusses application school practice base field control engineering xijing university school enterprise joint training base relying scientific research cooperation platform feasible take practice ability core engineering master training mode field control engineering xijing university innovation paper discuss improve practice ability students private colleges universities private colleges universities
purpose executive coaching become increasingly important enhancing organizational leaders professional effectiveness purpose paper contribute growing body research literature examines coaching techniques help school principals improve instructional leadership design methodology approach using protocol based theories practice framework argyris schn support principals deepening self reflection study added element guided peer coaching component group setting findings results confirmed effectiveness coaching protocol assisting principals deepening self awareness critical reflection regarding leadership including way principals core assumptions teaching leadership shaped outcomes problem solving strategies perceptions peer coaching element mixed however principals reported feeling affirmed sharing leadership challenges others indicated group coaching experience contributed sense professional community limitations principals willingness challenge one another core assumptions originality value study builds literature cites theories practice mechanism enhancing professional effectiveness represents iteration recent research studies applying concept work school principals findings affirm coaching protocol based theories practice well received principals serves deepen self reflection limited cases contribute sweeping changes thinking practice congruent concept double loop learning
metalloproteins bind utilize metal ions variety biological purposes due ubiquity metalloprotein involvement throughout processes across domains life proteins coordinate metal ions different biochemical functions great relevance understanding implementation biological processes toward ends improved methodology structurally functionally characterizing metal binding sites metalloproteins new ligand detection method statistically much robust producing estimated false positive false negative rates approximate approximate respectively additional improvements expand range metal ions coordination number effectively analyzed also inclusion additional quality control filters significantly improved structure function spearman correlations demonstrated rho values greater several metal coordination analyses even one rho value also improvements bond length distributions revealed bond length modes specific chemical functional groups involved multidentation using improved methods analyzed single metal ion binding sites ions wwpdb producing statistically rigorous results supporting existence significant number unexpected compressed angles subsequent aberrant metal ion coordination geometries cgs within structurally known metalloproteins recognizing aberrant cgs clustering analyses high correlations achieved structural functional descriptions metal ion coordination moreover distinct biochemical functions associated aberrant cgs versus nonaberrant cgs proteins wiley periodicals inc
recent years proponents usage based linguistics singled categorization possibly fundamental cognitive operation underlying acquisition use language despite increasing appeal importance categorization researchers yet offered explicit interpretations linguistic categories might represented brain vague allusions prototype theory especially implemented connectionist like frameworks paper discuss detail implications superimposing theoretical representations linguistic structures onto domain general models categorization first review evidence instance based exemplar based models categorization provide empirically theoretically better models domain general categorization linguistic categorization commonly cited alternative models argue three exemplar based models currently applied linguistic data skousen analogical model appears provide simplest straightforward account data appears fully compatible current understanding psychological capabilities operations underlie categorization behavior
numerous neuroimaging studies undertaken detect cerebral intrinsic activity major depressive disorder mdd resting state fmri fmri however inconsistent results hindered understanding exact neuropathology related mdd current meta analysis used state art conjunction analysis techniques systematically review summarize available neuroimaging studies using rsfmri amplitude low frequency fluctuation alff fractional alff falff mdd patients explored effect antidepressants intrinsic activity brain anisotropic effect size version signed differential mapping aes sdm applied investigate changes alff falff depression performed subgroup analysis group comparison medicated drug nave patients detect drug effect mdd patients conjunction analysis identify congruent results two methods meta regression used explore effects demographics clinical characteristics adult mdd patients showed robust increase intrinsic activity resting state anterior cingulate cortex acc alff falff studies subgroup analysis demonstrated increased activity acc prominent medicated patients seen drug nave mdd patients medication naive patients showed specific decreased activity cerebellum group comparison showed intrinsic acc activity elevated medicated mdd patients compared drug nave mdd patients meta regression analysis demonstrated increased acc activation positively correlated illness duration findings suggest increased activity acc likely associated antidepressant treatment decreased intrinsic activity cerebellum might specific biomarker current mdd elsevier inc rights reserved
paper describes implementation highly scalable parallel computational facility high speedup efficiency using relatively low cost hardware consists cluster desktop personal computers pcs connected via gigabit ethernet two levels parallelization implemented communication different pcs achieved using message passing interface mpi protocol domain decomposition automated based element numbering domain continuity assured largely numbering elements using front squasher code prior decomposition within shared memory parallelization implemented using either open multiprocessing openmp mpi protocol analysis three different problems number degrees freedom ranging shows speedup efficiency generally super linear speedup achieved several cases examined study hybrid mpi openmp approach generally performing better compared pure mpi method parallelization results demonstrate feasibility acquiring parallel computing facility relatively modest outlay within reach consulting engineering offices elsevier ltd rights reserved
conditions dermatology cause severe cracking flaking skin representing failure normal desquamation several hygroscopic substances affect moisturization stratum corneum identified treatment scaling disorders prominent among polyols alpha hydroxy acids elaborated new pharmaceutical product combines biomolecules glycerol ammonium lactate aim study evaluate physicochemical stability rheologic properties new skin care preparation
backgroundto consolidate new classification model addressed allergic hypersensitivity conditions according international classification diseases icd revision timeline propose real life application quality assurance methodology evaluate sensitivity accuracy anaphylaxis subsection methodswe applied field testing methodology analysing consecutive inpatients files documented allergies university hospital montpellier electronic database period year files clinically validated anaphylaxis manually blind coded icd current icd beta draft correspondence coding impressions regarding sensibility evaluated resultsfrom files related allergic hypersensitivity conditions anaphylaxis icd codes files patients anaphylaxis allergic hypersensitivity comorbidities description correspondence two coders perfect codes entities cohen kappa value icd codes cohen kappa value icd high agreement regarding sensibility icd usability cohen kappa value conclusionwe propose first attempt real life application validate new icd anaphylaxis subsection clearer improvement accuracy reaching agreement icd used allowing relevant diagnostic terms anaphylaxis included icd framework recognized importance clinicians also epidemiologists statisticians healthcare planners stakeholders
although much research examines physicians perceive patients study patients perceive physicians propose patients consider physicians like personally emotionless empty vessels higher individuals need care less value physicians traits related personal lives self focused emotions value physicians traits related patients patient focused emotions initial study participants recalled fewer personal facts marital status physicians seemed important health subsequent experiments participants higher need care believed physicians less personal emotions although higher need individuals patients clinic perceived physicians personally emotionless wanted clinic hire physicians displayed patient focused emotion discuss implications perceiving physicians empty vessels health care
background invasive candidiasis important cause sepsis premature infants associated high risk death neurodevelopmental impairment prevention become major focus low birth weight infants fluconazole increasingly used prophylaxis methods identified randomized placebo controlled trials evaluating fluconazole prophylaxis premature infants conducted united states obtained patient level data study investigators performed aggregated analysis occurrence endpoint infants received prophylaxis fluconazole placebo compared endpoints evaluated death death candida colonization fluconazole resistance among tested isolates safety endpoints evaluated included clinical laboratory parameters results fluconazole prophylaxis reduced odds death candida colonization drug exposure period compared infants given placebo odds ratios confidence interval respectively incidence clinical laboratory adverse events similar infants received fluconazole compared placebo statistically significant difference proportion tested isolates resistant fluconazole fluconazole placebo groups conclusions fluconazole prophylaxis effective safe reducing candida colonization premature infants impact resistance
improving disaster management recovery techniques one national priorities given huge toll caused man made nature calamities data driven disaster management aims applying advanced data collection analysis technologies achieve effective responsive disaster management undergone considerable progress last decade however best knowledge currently work summarizes recent progress suggests future directions emerging research area remedy situation provide systematic treatment recent developments data driven disaster management specifically first present general overview requirements system architectures disaster management systems summarize state art data driven techniques applied improving situation awareness well addressing users information needs disaster management also discuss categorize general data mining machine learning techniques disaster management finally recommend several research directions investigations
introduction use computers generally encouraged keep fast moving world technology research science extensive use computers result computer vision syndrome cvs prevalence increased dramatically main objective study assess prevalence associated factors cvs among bank workers gondar city northwest ethiopia methods cross sectional institution based study conducted among computer using bank workers gondar city april june data collected structured questionnaires observations checklists entered epi info analyzed statistical package social sciences spss version descriptive statistics logistic regression carried compute different rates proportion relevant associations results among total computer using bank workers prevalence cvs confidence interval blurred vision headache redness experienced symptoms inappropriate sitting position times adjusted odds ratio aor likely associated cvs compared appropriate sitting position working computer minutes without break nearly times aor likely suffered cvs compared taking break within minutes wearing eye glasses times aor likely suffer cvs compared wearing glasses conclusion three fourths computer using bank workers suffered cvs experienced symptoms blurred vision headache redness eyes appropriate sitting position working computer without break minutes wearing eye glasses independently associated cvs
background lymphoepithelioma like carcinoma lelc rare high grade carcinoma resembles nasopharyngeal lymphoepithelioma occur throughout body first reported bladder lelc incidence bladder carcinomas due rare occurrence prognoses ideal treatment guidelines clearly defined methods pubmed search performed using two terms lymphoepithelioma like carcinoma bladder review articles articles foreign languages expression studies studies performed bladder excluded report case lelc bladder including treatment outcome performed systematic review available english literatures including present case identify factors affecting disease free survival results one hundred forty cases bladder lelc analyzed mean age patients years ranging years males females pure lelc occurs often followed mixed lelc predominant lelc ebv testing negative cases tested mean follow length cases months evidence disease died disease alive metastasis died without disease cases recurrence average months prognosis significantly favorable patients presenting pure predominant forms lelc compared mixed type treatment significantly associated highest disease mortality lowest disease free survival turbt alone compared multi modality treatment conclusion conclude best treatment modality associated highest disease free survival multi modal treatment including radical cystectomy
background central nervous system cns infiltration cells associated neuroinflammation many neurodegenerative diseases including hiv associated dementia however role cells cns acute hiv infection ahi unknown methods analyzed phenotype gene expression cell receptor tcr repertoire hiv specificity cells cerebrospinal fluid csf unique cohort captured earliest stages ahi chronic uninfected results csf cells elevated ahi compared uninfected controls frequency activated csf cells positively correlated csf hiv rna markers cns inflammation contrast activated csf cells chronic hiv infection associated markers neurological injury microglial activation csf cells ahi exhibited increased functional gene expression profiles associated cells effector function proliferation tcr signaling unique restricted tcr vbeta repertoire contained hiv specific cells directed unique hiv epitopes compared periphery conclusions results suggest csf cells ahi expanding cns functional directed hiv antigens cells could thus play beneficial role protective injury seen chronic hiv infection combination antiretroviral therapy initiated early
present research examined particular types combat exposure may associated increased mental health symptoms also perceived benefits associated decreased mental health symptoms using longitudinal sample military personnel returned combat iraq afghanistan active combat experiences shooting directing fire enemy related higher levels perceived benefits following deployment whereas passive experiences recipient attack witnessing destruction perceived benefits months postdeployment associated lower posttraumatic stress disorder ptsd symptoms months later mediational analysis revealed although active combat experiences associated greater ptsd symptoms portion relationship reduced result association active combat experiences benefit finding discussion focuses additional research needed role benefit finding postcombat adjustment employees may derive benefits work predict future mental health symptoms
paper deals determine features included software developed metaheuristic techniques applied problem help software developers face contradictory goals show knowledge experience human experts enriched techniques idea obtaining better requirements selection produced expert judgment alone objective achieved embedding metaheuristics techniques requirements management tool takes advantage execution development stages software development project wiley periodicals inc
sexual orientation accurately identified photos faces previous work focused exclusively straight versus gay lesbian individuals across three studies current work investigated facial perception bisexual men women less socially salient category although participants could identify straight gay men chance levels trichotomous categorization task bisexual men categorized chance study participants perceived bisexual men significantly different straight men gay men study similarly whereas bisexual lesbian women rated differently groups distinguishable straight female targets study findings suggest straight non straight dichotomy categorization sexual orientation
secreted hepatokine fetuin emerges independent predictor type diabetes adulthood overall aims study investigate associations fetuin adiposity insulin resistance well relationship adipokines prepubertal children evaluate whether prepubertal obesity serum fetuin levels may either change predict responsiveness educational based weight excess reduction program studied prepubertal children boys girls tanner stage age years included cohort adolescents participated extensive italian school based survey according cole criteria individuals lean boys girls obese boys girls subset obese individuals boys girls age years also evaluated weight excess reduction program serum fetuin leptin total high molecular weight adiponectin levels well homeostasis model assessment insulin resistance assessed compared lean obese children exhibited higher aeuro dagger fetuin concentrations without differences sex fetuin positively associated adiposity homeostasis model assessment insulin resistance leptin levels multivariate analysis associations fetuin leptin homeostasis model assessment insulin resistance lost significance adjustment bmi score turn represented independent determinant fetuin adj notably weight excess reduction program fetuin levels dropped aeuro dagger basal interestingly significant differences fetuin concentrations responders responders found prepubertal children fetuin represents early marker adiposity reduction lifestyle intervention may partly contribute beneficial effects weight excess reduction program
recent research reveals playing prosocial video games increases prosocial cognitions positive affect helpful behaviors gentile greitemeyer osswald results consistent social cognitive models social behavior general learning model buckley anderson however experimental studies examined effects children previous research violent video games suggests short term effects video games largely based priming existing behavioral scripts thus unclear whether younger children show similar effects research years olds play prosocial neutral violent video game assessed helpful hurtful behaviors simultaneously new tangram measure prosocial games increased helpful decreased hurtful behavior whereas violent games opposite effects aggr behav wiley periodicals inc
turbocharging fsae engine required analysis knock high engine speeds knock testing engine performed rpm engine boosted kpa controlled proportional integral derivative pid controller actuated external wastegate cylinder pressure measurements acquired khz apart cylinder pressure recorded channels crank sensor cam sensor spark timing knock sensor data streaming labview used acquire data required lengths time streamed data post processed also labview cylinder pressure measurement signal conditioned typical charge amplifier used piezo sensors however measurements required form house signal conditioning discussed paper crank sensor signal coming mechanically modified crank sensor sprocket missing teeth signal replaced typical crank shaft encoder typically used conjunction cylinder pressure measurements cam sensor house design using inductive sensor triggered magnet inserted bolt attached onto cam drive sprocket signal amplified due low signal level cranking crank sensor signal together cam sensor signal used basis software generated crank angle required calculate instantaneous volume engine cylinder spark timing signal logical four low voltage spark plug output commands engine control unit ecu signal required analyze effect spark advance knock finally knock sensor signal conditioned provide low output impedance avoid ghosting national instruments data acquisition
recently amount genetic information increasing following completion human genome project bioinformatics information management coming fore however since bioinformatics information composed diverse kinds genetic information users easily approach use present paper high dimensionality information management scheme proposes enables users select pieces bioinformatics information highly frequently used using bernoulli distribution users easily approach pieces bioinformatics information preferred proposed scheme approach high dimensionality priority selection requires presentation two pieces bioinformatics information addition case proposed scheme since order priority information determined based kinds functions characteristics bioinformatics information users easily approach bioinformatics information according purpose use information according results experiments proposed scheme showed success rate higher existing schemes terms bioinformatics information searches delay time bioinformatics information services used independent users shown shorter existing schemes
researchers talk media media research media portrayed responsible reporting objective findings article summarizes efforts american psychological association public policy office violence media late looking range dynamics play school shootings blamed popular music rapidly evolving technology presidential campaign article explores complexity accurately representing psychological research medium findings could impact profits
study tested effect voter political orientation importance placed agency competence morality sociability qualities required president french republic furthermore assessed participants judgments five main candidates french presidential election dimensions results showed compared left wing voters right wing voters placed greater importance agency less importance morality sociability qualities required president right wing voters differentiated candidates respect agency competence whereas reverse pattern observed left wing voters voters differentiated candidates respect morality much sociability finally participants ratings candidates showed partisan effect left wing voters rated left wing candidates competent moral sociable true right wing candidates right wing voters ratings candidates agentic qualities less dependent voter political orientation data provide support people perceived qualities necessary president france
background social change intensified industrialization globalization changed people work lives also personal lives especially developing countries aim study provide evidence recommendations regarding family structure function mental health actively respond rapid social change methods cross sectional survey conducted face face door door july september hubei province central china family structure comprised alone couple nuclear family extended family family function measured using family apgar adaptation partnership growth affection resolve scale mental health measured using chinese version item general health questionnaire ghq results urban rural difference family structure among alone couple nuclear family extended family statistically significant respectively difference family function statistically significant general linear regression showed effect family structure mental health whether urban rural significant however effect family function significant especially regarding better family functioning better mental health conclusions combined effects family structure function mental health external form family family structure may important internal quality role family function might key improving residents family function would priority strategy family practice mental health
aim paper investigate influence novel opening strategies intake valves permeability cylinder flow multivalve spark ignition internal combustion engine specifically deactivation intake valve asymmetric valves lifts analysed compared standard symmetric valves opening purpose computational fluid dynamic cfd analysis performed using finite volume code experimental activity done steady flow rig investigation carried different intake strategies engine load conditions comparison cfd experimental flow coefficients shows good agreement results demonstrate proper combination different valves strategies permits effect throttling process medium low engine load minimised improving breathability intake system creating organised energised mean flow structures within combustion chamber
experimental tests investigating gigacycle fatigue properties materials commonly performed ultrasonic testing procedures allow significant reduction testing time induce significant temperature increment specimens order evaluate significance size effects fatigue strength materials authors recently proposed adopt gaussian specimens gigacycle tests fatigue specimens designed without taking account hysteretic damping effects stress distribution heat power dissipation however order evaluate temperature increment feasibility ultrasonic fatigue tests gaussian specimens total dissipated heat power well distribution dissipated heat power density along specimen must taken account present paper proposes analytical model validated finite element analysis permits evaluate effects hysteretic damping stress distribution dissipated heat power density distribution total dissipated heat power gaussian specimens elsevier ltd
background management atypical femoral fracture bisphosphonate therapy still remains controversy reported high rate complications aim study evaluate outcome intramedullary nailing patients atypical femoral fracture took bisphosphonate one year multicenter retrospective study methods gathered atypical femoral fractures seven institutions among atypical femoral fractures met inclusion criteria evaluated study average age years average duration bisphosphonate use years years medical records radiographs reviewed determine time union union rate need revision surgery restoration ambulatory function complications results twenty nine fractures healed within months without complications average time union except two non union weeks weeks two patients underwent revision surgery non union implant failure thirty seven patients achieved prefracture ambulatory function final follow conclusions although incidence delayed bone healing high atypical femoral fracture bisphosphonate therapy even treated intramedullary nailing incidence revision surgery implant failure relatively lower extramedullary devices elsevier ltd rights reserved
morphological reproductive physiological differences swamp buffalo bubalus carabanensis river buffalo bubalus bubalis development fetus weight fetus biometry reported river buffalo animals swamp buffalo aim study describe inherent variability fetus related measurements swamp buffalo pregnancy data based measurements fetuses new born claves swamp buffalo results show significant linear correlation exists estimated age fetuses parameters fetus sizes correlations crown rump length crl fetal parameters well fetus weight parameters conclusion data indicated feasibility value fetal measures swamp buffaloes used evaluation fetal development
breast cancer common invasive cancer among women incidence increasing risk assessment valuable recent methods incorporating novel biomarkers mammographic density artificial neural networks ann adaptive algorithms capable performing pattern pattern learning well suited medical applications potentially useful calibrating full field digital mammography ffdm quantitative analysis study uses ann modeling estimate volumetric breast density vbd ffdm japanese women without breast cancer ann calibration vbd performed using phantom data one ffdm system mammograms japanese women diagnosed invasive carcinoma negative findings analyzed using ann models learned ann estimated vbd validated phantom data compared intra patient qualitative composition scoring mri vbd inter patient classical risk factors breast cancer well cancer status phantom validations reached intra patient validations ranged vbd breast volume ann vbd agreed well rads scoring mri vbd ranging vbd breast volume vbd significantly higher women cancer associations age bmi menopause cancer status previously reported also confirmed ann modeling appears produce reasonable measures mammographic density validated phantoms existing measures breast density classical biomarkers breast cancer ffdm vbd significantly higher japanese women cancer
purposethe aim study compare chronic fallopian tubal inflammatory disease fibrosis patients general tubal pregnancy levonorgestrel lng emergency contraception failure methodswe retrospectively studied patients general following lng failure within conception cycle information gynecological features subject collected pelvic inflammatory disease associated sequelae assessed serum chlamydia trachomatis igg test laparoscopic evaluation tubal damage histopathological observation tube tissues chi square student tests employed determine difference two groups resultscompared general cases following lng failure subjects less likely history previous ectopic pregnancy adnexal surgery patients following lng failure less likely pelvic inflammatory disease associated sequelae general revealed positive reaction anti igg assessment tubal damage grade grade grade iii infiltration chronic inflammatory cells positive masson staining conclusionscompared cases general cases following lng failure exhibited reduced rates infection fallopian tubal inflammation fibrosis copyright john wiley sons ltd
purpose literature review examine available clinical studies performed last years identify causal relationship onset course autoimmune thyroid diseases aitds hypothalamic pituitary adrenal hpa axis sympathetic adrenomedullary system sam dys function women using pubmed web science scopus databases comprehensive search performed articles finally identified majority selected studies suggested causal connection graves disease stress well hashimoto thyroiditis variant postpartum thyroiditis stress however due heterogeneity protocols mainly based theoretical side effects stress immune neuroendocrine system different modalities used establish impact stress individuals definitive conclusions could reached explain mechanisms stress contributes onset aitds women determine whether stress management could help modifying course aitds
dual antiplatelet therapy dapt prescribed millions patients worldwide following coronary stenting dapt indicated lower risk ischemic events myocardial infarction including stent thrombosis ischemic stroke death cardiovascular causes significant number patients undergo noncardiac surgery may require dapt interruption poses significant clinical dilemma dapt interruption exposes patients potential risk stent thrombosis perioperative myocardial infarction conversely continuing dapt may associated excess bleeding complications observational data area conflicting randomized clinical trials guide practitioner decision making basis predominantly consensus recommendations various strategies managing dapt perioperative period proposed review presents commonly encountered clinical scenarios lead evidence based discussion practical strategies managing perioperative antiplatelet therapy patients following percutaneous coronary intervention published elsevier behalf american college cardiology foundation
multimedia forensics detection forgery joint photographic experts group jpeg images interesting challenging work jpeg double compression one common operations may occur tampering manipulation widely studied quality second compression higher quality first compression approaches obtained effective detection results however still falls short accurately detecting recompression second compression quality lower first compression quality seam carving originally designed content aware image resizing widely used computer vision multimedia processing legitimate applications also used forgery manipulation although several methods proposed detect seam carving based forgery date detection seam carving forgery recompression jpeg images well explored address highly challenging detection problems described proposed large feature mining based approach one hundred thousand features spatial domain dct transform domain developed ensemble learning used deal high dimensionality avoid overfitting may occur traditional learning classifier detection study demonstrates efficacy proposed approach discriminating jpeg recompression exposing seam carving forgery quality low quality jpeg recompression hence fills gap image forensics
hiv latency characterized reversible silencing viral transcription driven long terminal repeat ltr promoter hiv cellular viral factors regulating ltr activity contribute hiv latency certain repressive cellular factors modulate viral transcription silencing nef associated factor naf host nucleocytoplasmic shuttling protein regulates multiple cellular signaling pathways hiv production recently reported nuclear naf promoted nuclear export unspliced hiv gag mrna leading increased gag production demonstrate new functions naf regulating hiv persistence found naf contributes maintenance hiv latency inhibiting ltr driven hiv gene transcription nuclear factor kappa dependent manner interestingly naf knockdown significantly enhanced viral reactivation latently hiv infected jurkat cells primary central memory cells furthermore naf knockdown resting cells hiv infected individuals treated antiretroviral therapy significantly increased viral reactivation upon cell activation suggesting important role naf modulating hiv latency vivo findings provide new insights better understanding hiv latency suggest inhibition naf activity activate latently hiv infected cells may potential therapeutic strategy importance hiv latency characterized mainly reversible silencing ltr promoter driven transcription integrated provirus cellular viral proteins regulating ltr activity contribute modulation hiv latency study found host protein naf inhibited hiv ltr driven transcription hiv genes contributed maintenance hiv latency findings provide new insights effects host modulation hiv latency may lead potential therapeutic strategy hiv persistence targeting naf protein
fuel economy mpg based combined city highway environment labels affixed new vehicles model year mandated environmental protection agency fuel efficient model year passenger cars hybrid electric vehicles hybrids combine best features internal combustion engine electric motor powered batteries significantly improve fuel economy plug hybrids plugged wall outlet battery recharging driven electric motor relatively longer distance electric vehicles propelled electric motor powered using rechargeable battery packs emitting tailpipe pollutants among various battery technologies ion battery system preferable one automotive applications due relatively higher energy density review examines various aspects ion batteries related performance durability energy management safety related automotive applications review also discusses possibility automotive ion batteries towards second life stationary applications
aimed attention synthesis carbon dots dots ability interact dna suggest approach detection dna damage primarily dots modified amine moieties synthesized using one step microwave pyrolysis citric acid presence diethylenetriamine dots showed strong photoluminescence quantum yield addition dots possessed good colloidal stability exhibited positive surface charge zeta neutral interaction study dots dna fragment lambda bacteriophage performed dna binding resulted changes photoluminescent absorption properties dots binding dots dna also observed change dna electrophoretic mobility decreased ability intercalate ethidium bromide etbr moreover forster fluorescence resonance energy transfer fret dots etbr studied dots serve excitation energy donor etbr serves acceptor dna damaged using ultraviolet radiation lambda hydroxyl radicals intensity emitted photoluminescence significantly decreased concept proved analysis genomic dna cells dna isolated melanoma tissues
purpose purpose paper examine dimensionality environmental concern scale nep understand environmental worldviews malaysian project managers design methodology approach cross sectional survey conducted among developer organisations registered real estate housing developers association malaysia klang valley response obtained project managers final sample collected cases representing response rate per cent principal component analysis varimax rotation conducted investigate underlying structure nep items frequency distribution data set used gauge environmental worldviews respondents addition face face interviews carried gather information complements findings quantitative analyses findings five factors extracted due heavy cross loadings two items original scale dropped reducing item scale four factors retained explained per cent variance duly named human nature ecocrisis rights nature limits growth high scores pro nep pro dominant social paradigm items revealed existence ecological utilitarian view environment among project managers similar outcome obtained interviews project managers indicated efforts finding compatibility protecting environment exploiting natural resources development research limitations implications sample restricted housing developers klang valley thus findings generalised developer organisations construction occupational groups practical implications research supported multidimensionality claim environmental scale nep four distinctive dimensions identified usage individual subscales understanding environmental beliefs may reveal interesting patterns dimension could positive negative connotations human behaviours addition existence ecological utilitarian view environment revealed worldviews align well sustainable development principles originality value study one local studies attempt understand environmental worldviews project managers
capsular naevi cns lymph nodes lns relatively common occurring patients undergo surgery melanoma naevus count one principal risk factors melanoma well prognostic factor melanoma patients however little known occurrence melanoma patients basis naevus count case control study performed look naevus count differences positive negative melanoma patients cases positive matched age sex breslow thickness controls negative total naevus count recorded diagnosis compared two groups study conducted tertiary referral academic centre skin cancer twenty two positive patients matched negative patients mean breslow thickness range positive patients significantly associated increasing naevus count skin patients naevi reported odds ratio compared patients fewer naevi skin increased melanocytic migration lns might reason association cns high number melanocitic naevi skin could shed light physiology melanocytes could easy way predict patients greater risk cns copyright wolters kluwer health inc rights reserved
crowdsourcing new emerging distributed computing business model backdrop internet blossoming development crowdsourcing systems data size crowdsourcers contractors tasks grows rapidly worker quality evaluation based big data analysis technology become critical challenge paper first proposes general worker quality evaluation algorithm applied critical tasks tagging matching filtering categorization many emerging applications without wasting resources second realize evaluation algorithm hadoop platform using mapreduce parallel programming model finally effectively verify accuracy effectiveness algorithm wide variety big data scenarios conduct series experiments experimental results demonstrate proposed algorithm accurate effective high computing performance horizontal scalability suitable large scale worker quality evaluations big data environment
collaborative systems well established solutions sharing work among people computer graphics workflows still well established compared done text writing software development usually artists work alone share final models sending files paper present system collaborative digital sculpting prototype multiple artists concurrently sculpt polygonal mesh local machines changing vertex properties positions material brdfs system shares artists edits automatically seamlessly merges edits even happen region surface propose merge algorithm fast enough seamless collaboration respects users edits much possible support sculpting operation works geometry appearance modifications since sculpting artists alternatively perform fine adjustments large scale modifications algorithm based multiresolution edit representation handles concurrent overlapping edits different scales tested algorithm modeling meshes collaboratively different sculpting sessions found algorithm outperforms prior works collaborative mesh editing cases
work present efficient interferometric processing chain based advanced dinsar algorithm referred parallel small baseline subset sbas generation sentinel interferometric wide swath deformation time series able exploit distributed computing architectures presented sbas processing chain successfully implemented within esa geohazard exploitation platform provide demand automatic service unsupervised generation sbas displacement time series give idea effectiveness presented processing chain preliminary result show days interferometric analysis continental scale carried exploiting interferometric pairs acquired europe overall covered area
scheme water splitting promising approach based high performance photocatalysis harvesting broadband solar energy efficiency depends well defined interfaces two semiconductors charge kinetics exposed surfaces chemical reactions herein report facile cation exchange approach obtain compounds properties without need noble metals forming janus like structures consisting gamma mns cus high quality interfaces janus like gamma mns cus structures displayed dramatically enhanced photocatalytic hydrogen production rates mol full spectrum irradiation upon integration mnox oxygen evolution cocatalyst overall water splitting accomplished janus structures work provides insight surface interface design hybrid photocatalysts offers noble metal free approach broadband photocatalytic hydrogen production
paper presents novel adaptive bias technique based use squaring circuits tail current operational amplifier opamp controlled using auxiliary circuit design generates well controlled tail current first order approximation independent opamp common mode input voltage result parameters like common mode rejection ratio cmrr power supply rejection ratio psrr enhanced however differential input signal applied generates tail current proportional square opamp differential input voltage way currents opamp input pairs boosted thus improving slew rate experimental results cmos technology verify current slew rate enhancement factors less static current increase
support data intensive cluster computing increasingly important node virtual memory systems make effective use available fast storage devices swap temporary file space nswapl novel system transparently manages heterogeneous set storage options commonly found clusters including node ram disk flash ssd pcm network storage devices nswapl implements two level device driver interface top level appears node operating systems oss single fast random access device added swap partition cluster nodes transparently manages underlying heterogeneous storage devices including implementation network ram swapped data stored implements data placement migration prefetching policies choose underlying physical devices store swapped page data policies incorporate information device capacity system load strengths different physical storage media moving device specific knowledge nswapl policies based solely typical application access patterns characteristics underlying physical storage media nswapl policy decisions abstracted freeing implement specialized policies different combinations cluster storage nswapl requires changes system results benchmark tests show data intensive applications perform times faster nswapl enabled clusters show two level device driver design adds minimal latency underlying devices nswapl manages addition found even though nswapl network ram faster backing store prefetching policy distributes data multiple devices results increased parallelism lead better performance swapping single underlying device
bauer glenn alda andreassen ardau bellivier berk bjella bossini del zompo dodd fagiolini frye gonzalez pinto henry kapczinski kliwicki konig kunz lafer lopez jaramillo manchia marsh martinez cengotitabengoa melle morken munoz nery odonovan pfennig quiroz rasgon reif rybakowski sagduyu simhandl torrent vieta zetin whybrow impact sunlight age onset bipolar disorder bipolar disord authors journal compilation john wiley sons objective although bipolar disorder high heritability onset occurs several decades life suggesting social environmental factors may considerable influence disease onset study examined association age onset sunlight location onset method data obtained patients diagnosis bipolar disorder according dsm criteria data collected sites countries spanning latitudes degrees equator including data hemispheres age onset location onset obtained retrospectively patient records direct interviews solar insolation data amount electromagnetic energy striking surface earth obtained nasa surface meteorology solar energy sse database location onset results larger maximum monthly increase solar insolation location onset younger age onset coefficient controlling countrys median age maximum monthly increase solar insolation occurred springtime relationships found age onset latitude yearly total solar insolation maximum monthly decrease solar insolation largest maximum monthly increases solar insolation occurred diverse environments including norway arid areas california chile conclusion large maximum monthly increase sunlight springtime may important influence onset bipolar disorder
background neonatal hypernatremic dehydration nhd dangerous condition lead severe weight loss renal impairment central nervous system complications aimed evaluate consequences nhd infants second year life materials methods prospective case control study ghaem hospital mashhad iran sixty five healthy breastfed neonates serum sodium concentration mmol hypernatremic serum sodium concentration mmol neonates followed maternal neonatal factors compared two groups together growth parameters developmental milestones using denver developmental assessment scores assessed compared ages months respectively results weight infants months age significantly different two groups twenty five percent infants group developed nhd delay development months age corresponding values months months months age developmental delay approximate control group similar ages severity hypernatremia strongly correlated poor developmental outcome months serum sodium concentration neonates nhd group median peak serum sodium case group control group serious complications cerebral edema five cases hemorrhage five cases kidney stones six cases hypernatremic dehydration adverse effect child development especially first year life prevalence decreases advanced age growth problems also present first year life major signs symptoms infants poor prognosis admission poor feeding infants seizure infants hyperthermia infant lethargy infant conclusions nhd affects growth parameters developmental milestones children occasionally child weight gain normalized end first year life although developmental delay continued severity reduced age
parkinson disease neurodegenerative disorder characterized mitochondrial dysfunction oxidative stress usually accompanied imbalance mitochondrial dynamics changes mitochondrial morphology associated impaired function objectives study identify effects rotenone drug known mimic pathophysiology parkinson disease mitochondrial dynamics additionally study explored protective effects watersoluble coenzyme coq rotenone induced cytotoxicity murine neuronal cells results demonstrate rotenone elevates protein expression mitochondrial fission markers drp fis causes increase mitochondrial fragmentation evidenced mitochondrial staining morphological analysis water soluble coq prevented mitochondrial dynamic imbalance reducing drp fis protein expression pre rotenone levels well reducing rotenone treatmentassociated mitochondrial fragmentation hence watersoluble coq may therapeutic potential treating patients parkinson disease
objective describe labor delivery outcomes pregnant patients presenting hospital setting acute severe migraine headache attack earlier gestation methods retrospectively reviewed pregnancy delivery records database consecutive inpatient neurology consultations acute headache pregnant women year period results identified pregnant women acute migraine mean age years nearly half migraine aura chronic migraine presented status migrainosus complication rates included least one adverse outcome preterm delivery preeclampsia cesarean delivery low birthweight conclusions pregnant women seeking treatment acute migraine headache experienced higher rate preterm delivery preeclampsia low birthweight lower rate cesarean delivery local general populations half study patients experienced type adverse birth outcome suggesting pregnancies migraine patients presenting acute care setting may benefit intense surveillance
current study describes development decision support system dss estimating optimal tank size rainwater harvesting systems rhs site specific conditions incorporated analysis including local rainfall regime domestic demand water addition desired level confidence developed dss accessible via interface web application annual efficiency potential water savings rhss analyzed simulation based historical rainfall data rainfall distribution developed dss applied validated nine case studies state mexico considering three distinct rainfall regimes catchments area according estimates annual potential water savings per household may achieved average conditions elsevier ltd rights reserved
children knowledge food allergies self management developmentally based essential safe transition school despite growing number children food allergies starting school globally date little known young children knowledge food allergy capacity manage feelings perspectives starting school addressing gap pilot study interviewed six children aged four six years family homes sydney australia food allergy starting school data photo elicitation interviews utilising photos prompts analysed thematically results pilot study suggest child knowledge food allergy self control resist temptation ability communicate need help may help stay safe school therefore vital transition school implications pilot study research discussed
paper coupled higher order nonlinear schrodinger maxwell bloch equations studied ultrashort pulse propagation erbium doped birefringent fiber system lax pair constructed chnls system darboux method symbolic computation analytic two soliton solution obtained analyze specific problem design optimal system properly choosing special form variable coefficients using obtained two soliton solution tunneling femtosecond soliton barrier well investigated solitons passing barrier well unexpected behavior observed hidden possibilities switching action tunneling investigated
five body moshinsky brackets relate harmonic oscillator wavefunctions two different sets jacobi coordinates make straightforward calculate matrix elements variational calculations five body systems analytical expression transformation coefficients computer code written mathematica language presented accurate calculations program summary program title fbmb catalogue identifier aezt program summary url http cpc qub summaries aezt html program obtainable cpc program library queen university belfast ireland licensing provisions standard cpc licence http cpc qub licence licence html lines distributed program including test data etc bytes distributed program including test data etc distribution format tar programming language mathematica computer computers running mathematica operating system operating systems running mathematica ram bytes classification nature problem calculation five body moshinsky brackets solution method method based explicit expressions five body moshinsky brackets presented unusual features possibility calculating five body moshinsky brackets running time less one second single five body moshinsky bracket references shuyuan xiao xueli zhixuan deng hong chen journal mathematical physics elsevier rights reserved
background intimate partner violence ipv highly prevalent detrimental effects physical mental health women across world despite emerging evidence impacts cash transfers intimate partner violence pathways reductions violence occur remain explored randomised controlled trial cash kind food transfer programme northern border ecuador showed transfers reduced physical sexual violence mixed methods study aimed understand pathways led reduction methods conducted mixed methods study combined secondary analysis randomised controlled trial relating impact transfer programme ipv depth interviews focus group discussions male female beneficiaries sequential analysis strategy followed whereby qualitative results guided choice variables quantitative analysis qualitative insights used help interpret quantitative findings results found qualitative quantitative evidence intervention led reductions ipv three pathways operating couple household individual level reduced day day conflict stress couple improved household well happiness iii increased women decision making self confidence freedom movement found little evidence type ipv increased result transfers discussion cash kind transfers important programmatic tools decreasing ipv positive effects observed study seem depend circumstances may exist settings programmes inclusion training component moreover programme built upon rather challenged traditional gender roles targeting women transfer beneficiaries framing intervention umbrella food security nutrition domains traditionally ascribed women conclusions transfers destined food consumption combined nutrition training reduced ipv among marginalised households northern ecuador evidence suggests reductions realised decreasing stress conflict improving household well enhancing women decision making self confidence freedom movement
rats perirhinal cortex lesions received multiple object recognition trials within continuous session examine whether show false memories experiment focused exploration patterns first object recognition test postsurgery trial contained novel familiar object perirhinal cortex lesions reduced time spent exploring novel objects affect overall time spent exploring test objects novel plus familiar replications subsequent cohorts rats experiments repeated pattern results recognition memory data combined experiments giving totals perirhinal lesion rats surgical sham controls perirhinal cortex lesions caused marginal reduction total exploration time decrease time novel objects often compensated increased exploration familiar objects experiment also assessed impact proactive interference recognition memory evidence emerged prior object experience could additionally impair recognition performance rats perirhinal cortex lesions experiment examined exploration levels rats given pairs novel objects explore despite perirhinal cortex lesions exploration levels comparable control rats results experiment support notion perirhinal lesions increase sensitivity proactive interference overall findings question whether rats lacking perirhinal cortex typically behave novel objects familiar show false recognition rather rats retain signal novelty struggle discriminate identity signal
goal study determine whether differences exist problematic substance use receipt services nativity born foreign born legal status citizen legal resident undocumented among latino parents reported child abuse neglect used data national survey child adolescent well weighted bivariate chi square tests compare rates problematic substance use services receipt nativity legal status weighted logistic regression models estimated effect immigrant status odds service receipt rates problematic substance use significantly different nativity legal status service receipt significantly lower foreign born versus born parents compared citizens legal residents services receipt least likely undocumented parents adjusting covariates nativity affect services receipt undocumented legal status reduced odds receiving services data indicate disparities exist receipt substance use services among immigrant parents especially undocumented parents compared born parents findings also suggest protective effect immigrant status problematic substance use immigrant paradox may apply child welfare involved families elsevier ltd rights reserved
education department built environment eindhoven university technology aims prepare students multidisciplinary design teams bachelor program offers broad range incorporating essentials urbanism architecture structure building physics real estate construction services cetera broad bsc program lays foundation students followed master program focuses specialization six specializations architecture urban design planning structural design building physics services real estate management development construction management engineering multidisciplinary bsc offering variety knowledge courses lectures department also puts lot effort train students gain experiences integral design teams takes shape studios best expressed multi project semester assignment last year bachelor assignment organized coaches specializations master assessment always practice based issue students cooperate design team one semester developing multi project long route took place many years several adjustments according experiences information gathered student inquiries paper gives global overview present setup contextualize assignment main part paper focuses kickoff first weeks students start parallel studios meant put track integral design studio combines two disciplines compels students precede design analyzing kind issues light specific assignment complexity assignment frequently ask students fill enquiry able draw conclusions major changes last assignments
introduction ruxolitinib potent selective jak jak inhibitor shown superiority compared available conventional chemotherapies terms reduction splenomegaly improvement symptoms quality life areas covered data published overall survival major randomized sponsored trials independent series patients detailed indeed data regarding action ruxolitinib allele burden reduction potential activity drug pathogenetic mechanisms involved increased fibrosis reviewed expert commentary data extrapolated clinical trials demonstrated advantage survival drug compared placebo best available therapy moreover long term jak allele burden reduced treatment patients achieved improvement stabilization fibrosis latter activity several pathways involved conclusion ruxolitinib able modify natural outcome patients affected myelofibrosis independently nature primary secondary diseases
cardiovascular disease exerts enormous burden women health intake healthy diet may reduce burden however social norms economic constraints often factors restrain women paying attention diet underpinned critical realism study explores gender sex influences decision making regarding food consumption among women low socioeconomic status ses study carried two cardiac facilities karachi pakistan participants male female different ethnic backgrounds received health education using interpretive descriptive approach study identified major barriers healthy diet proscribed gender roles lack women autonomy power male domination abusive behaviours cardiovascular risk disease outcomes pakistani women low ses likely escalate individual structural barriers reduced using multifactorial approaches
myeloproliferative neoplasms associated lymphoproliferative diseases following administration cytotoxic drugs exposure radiation rare prior therapy present study reports case year old female history transient ischemic attack patient presented palpable mass epitrochlear area left arm simultaneously diagnosed follicular lymphoma unclassifiable myeloproliferative neoplasm excisional lymph node biopsy revealed stage follicular lymphoma grade laboratory findings demonstrated leukocytosis erythrocytosis thrombocytosis decreased erythropoietin biopsy bone marrow revealed hypercellularity predominance erythroid cells large polylobated megakaryocytes increased mitotic figures evidence lymphomatous infiltration janus kinase mutation also detected cells derived bone marrow specimen following local excision lymph node left epitrochlear area radiation delivered involved field dose fractions patient started hydroxyurea twice per day orally weeks subsequent radiotherapy administered twice per day maintenance therapy six month follow white blood cell count hemoglobin levels platelet count reduced patient healthy condition computed tomography scan neck chest abdomen indicated abnormalities best knowledge present study first case report follicular lymphoma coexisting unclassifiable myeloproliferative neoplasm previously healthy patient molecular genetic studies required evaluate infrequent disease association
reduced bone density secondary osteoporosis resulting increased risk fracture significant complicating factor inflammatory arthritides exact etiology systemic bone loss fully elucidated recent insights tumor necrosis factor super family tnfsf revealed potential role death receptor tnfrsf one ligands tnf like protein tla tnfsf mechanisms tla signalling modulates bone loss unclear investigated effect signalling upon osteoclast dependent chemokine mmp production unravel novel mechanisms whereby pathway regulates formation dependent bone resorption collagen induced arthritis cia established mice joints sectioned analysed histologically bone damage systemic trabecular bone loss distal affected joints compared micro ablation protected dba mice development progression cia joints ankle mid foot almost free bone erosions long bones mice cia protected systemic trabecular bone loss vitro expression confirmed primary human osteoclast precursors flow cytometry cells treated tla osteoclast differentiation medium trap osteoclasts bone resorption levels osteoclast associated chemokines ccl ccl cxcl mmp measured tla intensified human osteoclast differentiation bone resorption increased osteoclast associated production ccl mmp data reveals pathway attractive therapeutic target combat adverse bone pathology associated inflammatory arthritis demonstrate critical pathogenesis murine cia associated secondary osteoporosis furthermore identify novel mechanism pathway directly enhances human formation resorptive activity controlling expression activation ccl mmp authors published elsevier inc
colorectal carcinoma one fatal cancers date underlying mechanisms entirely understood recent epidemiological studies clinical trials begun provide insights links estrogens colorectal carcinoma results obtained established animal models indicated abnormal high levels estrogens promote tumorigenesis colitis associated carcinoma estrogens regulate biological events mainly two distinct receptors alpha beta combined receptor estrogens translocate nucleus act transcription factors modulate several signaling pathways since organ destruction parenchymal loss result hormone inactivation disorder patients liver cirrhosis always high levels endogenous estrogens predominant causes liver palm spider angioma gynecomastia testis atrophy meanwhile several population based studies confirmed patients liver cirrhosis face higher risks colorectal carcinoma compared general population although influencing factors may complicated high level endogenous estrogens proposed important pathogen several studies particular focus menopause women provided contradictory results estrogens may protect patients cancers however low levels endogenous estrogens menopause women administration route composition drugs could lead different conclusions exact effect estrogens pathogenesis colorectal carcinoma patient liver cirrhosis starting dissected
background screening large numbers persons population low prevalence disease leads many false positives however populations low hcv prevalence may sometimes recommended hcv screening instance patients healthcare workers possible healthcare related exposure objectives determined percentage true false positive hcv antibody anti hcv test results among participants national health nutrition examination study nhanes nationally representative study approximately hcv infection prevalence much lower groups typically recommended hcv screening study design anti hcv test confirmation performed using recombinant immunoblot assay riba test follow hcv rna testing results overall nhanes participants tested anti hcv screening reactive tested riba confirmed true positive false positives many others riba indeterminate likely false positive false positive tests overall prevalence chronic infection among testing anti hcv screening reactive much lower would expected due disease clearance alone approximately conclusions screening anti hcv positive tests followed hcv rna test order confirm whether patient current infection infected persons referred care treatment avoid significant morbidity mortality associated chronic hcv infection published elsevier
separation aromatic aliphatic mixtures significant chemical industry pervaporation attracted increasing attention due low energy consumption environmentally friendly process however formation membranes mostly use toxic organic solvents whereas study water used instead prepare membrane separating aromatic aliphatic mixtures dispersed water form micelles deposited onto surface tubular porous ceramic substrate negative pressure driven assembly method emulsion composite membranes characterized tem sem ftir crosslinking density also tested using nmr xld analyzing system membranes used separating aromatic aliphatic mixtures pervaporation results showed compared membrane prepared dmf pervaporation separation index psi composite membrane formed using water solvent fold increased separating toluene heptane mixtures prepared composite membranes showed better comprehensive pervaporation performance facile strategy may potential application pervaporation separating aromatic aliphatic mixtures industry elsevier rights reserved
laboratory rabbit oryctolagus cuniculus widely used model human diseases size permits non lethal monitoring physiological changes similar disease characteristics novel transgenic tools zinc finger nuclease method sleeping beauty transposon mediated bac transgenesis recently adapted laboratory rabbit opened new opportunities precise tissue developmental stage specific gene expression silencing coupled increased transgenic efficiencies many facets human development diseases investigated rodents especially true early prenatal development long lasting effects health complex disorders economically important diseases atherosclerosis cardiovascular diseases first transgenic rabbits models arrhythmogenesis mimic human cardiac diseases much better transgenic mice hereby underline importance non mouse models another emerging field epigenetic reprogramming pathogenic mechanisms diabetic pregnancy rabbit models indispensable beyond rabbit used decades major source polyclonal antibodies recently monoclonal antibody production alteration genome increase efficiency value antibodies humanization immunoglobulin genes increasing expression special receptor receptor augments humoral immune response current demand
study preferred thinking styles among senior health professionals reported total medical consultants senior nurses health managers two public teaching hospitals adelaide australia invited via personal letter complete questionnaire comprising measures thinking style rational experiential inventory cognitive style two dimensions myers briggs type indicator managers reported higher preference rational reasoning nurses whereas medical consultants reported lower preference experiential reasoning managers nurses cognitive style largely homogenous although generalisation findings may limited due small sample sizes self selection participants understanding thinking styles senior health professionals likely inform design evaluation future change strategies
need development new drugs prevent osteoporosis related fractures fractures projected increase present drugs modest efficacy significant side effects poor compliance illustrate difficulties development new drugs author reviews fate several drugs failed gain regulatory approval drugs include arzoxifene lasofoxifene roncalceret odanacatib romosozumab abaloparatide new drugs presently phase development anticipated ongoing studies mechanisms signaling pathways involved regulation bone remodeling open new opportunities targeted pharmacological interventions increase bone strength however perfect drug still long way face many obstacles approval
objective users hormonal long acting reversible contraception larc report weight gain side effect studies assessed body composition change among larc users evaluated weight body composition healthy women using levonorgestrel intrauterine system lng ius copper intrauterine device copper iud etonogestrel implant eng implant hypothesized weight gain body composition months would differ copper iud lng ius eng implant users study design performed prospective cohort study subgroup women enrolled contraceptive choice project initiated lng ius copper iud eng implant inclusion criteria included lack metabolic eating disorders change body weight months enrollment measured changes weight body composition body fat percentage total body fat mass total lean mass total body mass women continued method months results analyzed data participants lng ius users copper iud users eng implant users mean age years white college education nulliparous although lean body mass increased months lng ius copper iud users eng implant users changes body weight body composition differ groups adjusted model black race associated change total body mass conclusions among continued method months changes body weight composition differ copper iud lng ius eng implant users elsevier inc rights reserved
paper reports design implementation integrated operational amplifier bipolar sic elaborates operation positive feedback configuration opamp studied different feedback setups closed loop compensated amplifier comparator hysteresis schmitt trigger relaxation oscillator measurement results suggest stable closed loop opamp similar gain schmitt trigger constant threshold levels wide temperature range relaxation oscillator tested khz setups tested degrees degrees elsevier ltd rights reserved
secure shell protocol ssh well known standard protocol mainly used remotely accessing shell accounts unix like operating systems perform administrative tasks result ssh service appealing target attackers aiming guess root passwords performing dictionary attacks directly exploit service identify situations article addresses detection ssh anomalous connections intrusion detection perspective main idea compare several strategies approaches better detection ssh based attacks test classification performance different classifiers combinations ssh data coming real world honeynet gathered analysed comparison purposes draw conclusions data collection packet based flow data analysed wide range classifiers ensembles applied data well different validation schemes better analysis obtained results high rate classification results lead positive conclusions identification malicious ssh connections
software engineering predictive modeling involves construction models help software metrics estimating quality attributes recently use search based techniques gained importance help developers project managers identification optimal solutions developing effective prediction models paper perform systematic review primary studies january december analyze predictive capability search based techniques ascertaining four predominant software quality attributes effort defect proneness maintainability change proneness review analyses effective use application search based techniques evaluating appropriate specifications fitness functions parameter settings validation methods accounting stochastic natures evaluation developmental models use well known statistical tests furthermore compare effectiveness different models developed using various search based techniques amongst also prevalent machine learning techniques used literature although studies use search based techniques predicting maintainability change proneness found results application search based techniques effort estimation defect prediction encouraging hence comprehensive study associated results provide guidelines practitioners researchers enable make proper choices applying search based techniques specific situations
pillar industry national economy logistics industry heavy responsibility low carbon economy essentially logistics point view paper proposed concept low carbon logistics departure status quo china logistics industry energy consumption pointed cause problem facing china logistics industry achieve low carbon propose way achieve low carbon logistics new perspective study low carbon economy proposed countermeasures effective way promote healthy growth logistics industry
objectivesthe joint united nations programme hiv aids unaids world health organization goals propose people living hiv know hiv status diagnosed receive antiretroviral therapy art durable viral suppression estimated continuum hiv care entire hiv infected population sweden methodsthe swedish infcare hiv cohort study collects viral loads counts viral sequences along demographic clinical data electronic clinical decision support system almost diagnosed hiv infection included database corresponding diagnosed subjects living hiv sweden december resultsusing hiv surveillance data reported public health agency sweden estimated hiv infected subjects sweden remain undiagnosed among diagnosed patients linked care remained care december patients art total treatment least months viral load patients living hiv virologically suppressed sweden already achieved target suppression first country reported meet unaids goals
background widespread consensus importance safe secure communication healthcare especially trauma care time limiting factor although non verbal communication impact communication individuals limited knowledge trauma team leaders communicate purpose study investigate trauma team members positioned emergency room leaders communicate terms gaze direction vocal nuances gestures trauma team training methods eighteen trauma teams audio video recorded trauma team training emergency department hospital northern sweden quantitative content analysis used categorize team members positions leaders non verbal communication gaze direction vocal nuances gestures quantitative data interpreted relation specific context time sequences leaders gaze direction speech time gestures identified separately registered time seconds proportions total training time results team leaders gained control important area emergency room inner circle positioned heads team using gaze direction gestures vocal nuances verbal commands solidified verbal message changes position required attention collaboration leaders spoke hesitant voice silent expressed ambiguity non verbal communication team members took leader tasks discussion teams leader control inner circle members seemed awareness roles tasks knowing time space tasks needed executed deviations leaders communication increased ambiguity communication consequences teamwork communication taken granted needs practiced regularly technical skills need trained simulation training provides healthcare professionals opportunity put verbal nonverbal communication focus order improve patient safety conclusions non verbal communication plays decisive role interaction trauma team members verbal non verbal communication focus trauma team training even important inexperienced leaders since vague non verbal communication reinforces ambiguity lead errors
cloud security become one emergent issues immense growth cloud services major concern cloud security insider threat harm poses therefore defending cloud systems insider attacks become key demand work deals insider threat cloud relational database systems reveals flaws cloud computing insiders may use launch attacks discusses load balancing across availability zones may increase insider threat mitigate kind threat paper proposes four models peer peer model centralized model mobile knowledgebases model guided mobile knowledgebases model discusses advantages well limitations moreover paper provides experiments analysis compare among proposed models demonstrate effectiveness show conditions work highest performance copyright john wiley sons ltd
paper presents experimental study development implementation tests control strategy applied pressure control hydraulic pumping systems strategy aims avoiding severe damage hydraulic system due water hammer effects accomplish proposed suitable modulating control pump electric motor torque order keep pressure values safe region set operating conditions rig system developed perform experimental tests step response tests hydraulic rig system transfer function model relating pipe pressure motor speed identified subsequently applied pid controller design pid control synthesis performed using pole placement techniques performance assessed comparison pid controller adjusted using ziegler nichols rules obtained results show proposed control strategy able assure safe plant operation even extreme operation conditions case water hammer effect
little known risk factors suicide ideation attempts among domestic violence offenders guided interpersonal psychological theory suicide cross sectional study examined risk factors suicide ideation attempts among men women arrested domestic violence mandated attend batterer intervention programs men reported greater capability suicide gender differences found perceived burdensomeness thwarted belongingness controlling correlates suicide ideation perceived burdensomeness thwarted belongingness interaction perceived burdensomeness associated suicide ideation suicide attempters exhibited greater perceived burdensomeness drug use problems borderline personality disorder symptoms depressive symptoms suicide ideation capability suicide nonattempters gender moderate associations ipts constructs suicide ideation attempts findings parallel tests interpersonal psychological theory samples additional work needed identify factors distinguish risk suicide ideation risk suicide attempts among domestic violence offenders
introduction janus kinases jaks family four enzymes jak jak jak tyrosine kinase tyk critical cytokine signalling strongly linked cancer inflammatory diseases currently two launched jak inhibitors treatment human conditions tofacitinib rheumatoid arthritis ruxolitinib myeloproliferative neoplasms including intermediate high risk myelofibrosis polycythemia vera areas covered review covers patents claiming activity one jak family members period inclusive covers patents applicants split two parts authors ordered recent patents according primary applicant name part covering expert opinion inhibition jak family kinases area growing interest catalysed maturity data marketed inhibitors ruxolitinib tofacitinib late stage clinical trials many applicants pursuing traditional fast follower strategies around inhibitors range chemical strategies adopted challenge show sufficient differentiation originator compounds since dose limiting toxicities agents appear target mechanism related also considering agents may available generic compounds time follower agents reach market
heat transfer keystone sub model engine simulation tools since affects targeting parameters power output efficiency emissions part work reported thorough review heat transfer measurements literature using design experiments doe two measurement matrices constructed one motored one fired operation present paper focuses measurements fired operation analyses heat transfer phenomena systematic way first effect dependent engine settings heat flux analyzed consistent way using anova analysis variance second also discusses influence gas properties heat flux overlooked many authors third validity reynolds analogy modelling approach checked several improvements proposed elsevier ltd rights reserved
backgroundbrain derived neurotrophic factor bdnf may play vital role homeostatic regulation intestinal barrier integrity aimed investigate physiological role bdnf maintaining intestinal epithelial barrier using postinflammatory irritable bowel syndrome ibs mice explore underlying molecular mechanisms using intestinal epithelial cells vitro methodspostinflammatory ibs mice induced intrarectal administration trinitrobenzene sulfonic acid allowed recover days frequency defecation fecal water content colonic epithelial integrity expressions bdnf tight junction proteins occludin claudin claudin ibs mice investigated based results animal studies performed pcr western blots assess bdnf stimulation bdnf knockdown impacted proteins intestinal epithelial cells key resultswater content stools significantly increased ibs mice compared controls colonic mucosa ibs mice displayed epithelial barrier defects exhibited increased protein expressions bdnf claudin decreased protein expressions occludin claudin furthermore sirna bdnf cells could effectively suppress bdnf gene protein expressions subsequently reduce gene protein levels cells incubated different doses exogenous bdnf significant increases occludin claudin decreases claudin protein observed conclusions inferencesbdnf may play role regulating intestinal epithelial barrier via affecting expression proteins
erythromelalgia debilitating neurovascular disease refractory numerous treatment modalities present study reported case year old woman diagnosed secondary polycythemia vera effectively treated use patient controlled epidural analgesia pcea interferon alpha therapy study aimed provide clinical information condition based findings present case previously reported cases pcea containing local anesthetics dexamethasone fentanyl resulted nearly complete relief symptoms furthermore continuous use interferon alpha treatment completely relieved symptoms conclusion pcea interferon alpha may promising treatments secondary
introduction lower urinary tract dysfunction normal pressure hydrocephalus received little attention scientific community aim review article discuss diagnostic therapeutic options patients sources literature review medline publications urinary incontinence normal pressure hydrocephalus conducted following keywords used hydrocephalus normal pressure bladder dysfunction urinary incontinence overactive bladder urinary bladder neurogenic prospective retrospective studies well previous reviews analyzed results urinary symptoms normal pressure hydrocephalus mainly represented overactive bladder significant burden concerned patients isolated overactive bladder frequent urinary incontinence detrusor overactivity seen cases neuro surgery efficient urinary symptoms patients bladder recovery surgery relates increased mid cingulate perfusion probably linked functional restoration mid cingulate normally inhibits micturition reflex medical options added surgery include anticholinergic drugs unable pass blood brain barrier transcutaneous electrical nerve stimulation sacral neuromodulation conclusion actually insufficient concern urinary symptoms normal pressure hydrocephalus article highlights importance harmonization neurourological practices pre therapeutic evaluation patients suffering normal pressure hydrocephalus elsevier masson sas rights reserved
introduce different high order time discretization schemes backward semi lagrangian methods schemes based multi step schemes like adams moulton adams bashforth schemes combined backward finite difference schemes apply methods transport equations plasma physics applications numerical simulation instabilities fluid mechanics context backward semi lagrangian methods time discretization strategy particularly efficient accurate spatial error discretization becomes negligible allows use large time steps elsevier rights reserved
background opiate abuse overdose reached epidemic levels united states however despite significant advances animal vitro models little knowledge directly accrued regarding neurobiology opiate addicted human brain methods used postmortem human brain specimens homogeneous european caucasian population heroin users transcriptional epigenetic profiling well direct assessment chromatin accessibility striatum brain region central reward emotion rat heroin self administration model used obtain translational molecular behavioral insights results transcriptome approach revealed marked impairments related glutamatergic neurotransmission chromatin remodeling human striatum series biochemical experiments tracked specific location epigenetic disturbances hyperacetylation lysine histone showing dynamic correlations heroin use history acute opiate toxicology targeted investigation gria glutamatergic gene implicated drug seeking behavior verified increased enrichment lysine acetylated histone discrete loci accompanied enhanced chromatin accessibility hyperacetylated regions gene body analogous epigenetic impairments detected striatum heroin self administering rats using translational model showed bromodomain inhibitor blocks functional readout acetylated lysines reduced heroin self administration cue induced drug seeking behavior conclusions overall data suggest heroin related histone hyperacetylation contributes glutamatergic transcriptional changes underlie addiction behavior identify promising candidate targeted clinical interventions heroin use disorder
background role migration risk factor remains unknown mood disorders poor data sought examine prevalence severity mood disorders bipolar disorder unipolar depressive disorder udd dysthymia first second third generation migrants france methods mental health general population survey interviewed individuals prevalence lifetime mood disorders comorbidities clinical features compared migrants non migrants generation analyses adjusted age sex level education results prevalence lifetime mood disorder higher migrants compared non migrants increased prevalence significant udd dysthymia although prevalence increased third generation migrants udd likely display comorbid psychotic disorder compared non migrants udd cannabis use disorders common migrant groups mood disorders whereas alcohol use disorders higher migrants udd posttraumatic stress disorder frequent among migrants udd limitations study used cross sectional prevalence data could biased differences course disease according migrant status moreover design allow causality conclusion generalization main findings conclusion mood disorders common among migrants especially udd moreover migrants mood disorders presented severe profile increased rates psychotic substance use disorders
objectives retrospective study aims evaluate prevalence maxillofacial trauma developing country along pattern etiology management data present study collected department dentistry esic medical college post graduate institute medical sciences research chennai india materials methods medical records patients treated maxillofacial injuries may november retrospectively retrieved analyzed prevalence pattern etiology management maxillofacial trauma spss software version used data analysis results maxillofacial fractures accounts total injuries mean standard deviation age patients years minimum age years maximum age years adults years age groups commonly involved male female ratio statistically significantly higher proportion males commonly involved accident injuries conclusion common etiology maxillofacial injury road traffic accidents rta followed falls assaults sports injuries seem less rta motorized two wheelers mtw common cause incidents majority victims rta young adult males ages years malar bone maxilla common sites fracture followed mandible right side zygomatic complex predominant side mtw injury majority zygomatic complex fractures treated conservative management open reduction internal fixation performed indicated fracture patients
goal reducing environmental impact become urgent imperative chinese leadership central potentially competing objective policy makers planners remains economic growth job creation paper systematically examines perceived trade offs pollution control regulation employment microeconomic macroeconomic scale synthesize theoretical literature employment impact pollution control regulation firm industry economy levels summarize theoretically sufficient conditions employment enhancing regulation paper examines experience impact pollution control job growth draws mechanisms job growth pollution control congruent examining adaptability chinese context specifically paper highlights importance targeting regulations toward sectors labor costs represent small portion overall costs sectors low labor intensity demonstrate chinese context transition economy higher proportion tertiary output likely facilitate joint strategy stringent pollution control combined job growth
several lines evidence suggest definite unique link cns demyelinating diseases autoimmune thyroid disease aitd aim current study systematically compare clinical laboratory features patients coexistent aitd cns demyelinating disease patients cns demyelinating disease forty four patients coexisting cns demyelinating disease aitd identified clinical radiological features recorded blood dna collected tested hla type response cells antibodies variety antigens patients multiple sclerosis without aitd healthy individuals included controls patients coexisting aitd cns demyelinating disease almost exclusively female prominent spinal cord involvement main neurological finding hla molecules carried individuals cns demyelinating disease aitd differed patients healthy individuals furthermore patients cns disease aitd showed less cell reactivity patients alone myelin proteolipid protein compared groups showed elevated levels cell reactivity calcitonin gene related peptide present cns thyroid elevated levels cell antibody leucine rich repeat containing protein coupled receptor lgr molecule expressed brainstem spinal cord homolog thyroid stimulating hormone receptor suggest reactivity autoreactive immune cells patients antigens present thyroid spinal cord potential mechanism underlying pattern lesion development cns patients coexisting aitd might indicate novel mechanism disease pathogenesis patients
delamination disbanding void low impact resistance visible internal damage damages uniquely found structure damage found structure require repair inspection need done detect damage structure structure repaired non destructive inspection ndi structural health monitoring shm concept used detect flaws structures shm differs ndt system used monitor integrity mechanical structures continuous independent way shm helps reduce financial cost maintenance shm monitor situation active passive states either online offline monitoring use shm augment ndi application replace paper presents damage identification technique using improved design wireless structural health monitoring system smart pzt sensors used actuator receiver coupled two xbee two ardiuno signal generator signal receiver program execution transmitting receiving ultrasonic guided wave via pzt sensor written makerplot acquired results showed wave even non defected area disrupted affected area authors published iase
rapid sensitive accurate specific ultra performance liquid chromatography coupled tandem mass spectrometry uplc method detection nitrosodiethanolamine ndela highly toxic contaminant cosmetic raw materials products developed validated systematized sample preparation steps developed according product types various spe cartridges columns examined establish condition spe chromatographic separation ndela sample cleanup steps consisting solvent liquid liquid extraction tailored various sample matrix types established prior mixed mode spe bond elut accucat chromatographic separation achieved within min porous graphitic carbon pgc column using gradient elution mobile phase ammonium acetate containing acetic acid methanol ndela monitored using electrospray positive ionization mass spectrometry multiple reaction monitoring mrm mode quantifier qualifier ion ndela internal standard standard curves linear concentration range correlation coefficient higher limit detection clod limit quantification loq respectively standard solution intra inter day precisions estimated accuracies within range validated method successfully applied analysis real samples including raw materials skin care make shampoos hair products elsevier rights reserved
rett syndrome rtt omim neurodevelopmental disorder early childhood primarily caused mutations gene encoding methyl cpg binding protein mecp various molecular functions ascribed mecp including regulation histone modifications associated repressive chromatin remodeling role mechanisms pathophysiology rtt remains unclear explore whether neuronal expression histone lysine specific methyl transferase setdb set domain bifurcated eset kmte normally present low levels differentiated neurons rescues rtt like phenotype mecp deficient mice myc tagged setdb cdna expressed tau locus ubiquitous expression cns neurons control calcium calmodulin dependent protein kinase promoter selectively target postmitotic neurons forebrain however setdb transgene lead enhanced neurological deficit tausetdb allele shortened life span mice brain wide deletion mecp prenatal development contrast neurological deficits premature death observed setdb tausetdb mice expressing wildtype mecp however levels trimethylated pericentromeric repeats fully maintained differentiated neurons symptomatic mecp null mutant mice based results draw two conclusions first neuronal chromatin rtt brain affected generalized deficit trimethylation second artificial regulation repressive chromatin mark via setdb gene delivery specifically neurons harmful mecp deficient brain article part special issue entitled trends neuropharmacology memory erminio costa elsevier ltd rights reserved
dramatic growth network attacks new set challenges raised field electronic security undoubtedly firewalls core elements network security architecture however firewalls may include policy anomalies resulting critical network vulnerabilities substantial step towards ensuring network security resolving packet filter conflicts numerous studies investigated discovery analysis filtering rules anomalies however emphasis given resolution anomalies legacy work correcting anomalies operate premise creating totally disjunctive rules unfortunately solutions impractical implementation point view lead explosion number firewall rules paper present new approach performing assisted corrective actions contrast state art family radically disjunctive approaches lead prohibitive increase firewall size sense allow relaxation correction process clearly distinguishing constructive anomalies tolerated destructive anomalies systematically fixed distinction constructive destructive anomalies assisted network administrator supports fact major role heart corrective process best knowledge assisted approach relaxed resolution packet filter conflicts investigated provide theoretical analysis demonstrate scheme results sound indeed result conflict free policy addition implemented solution user friendly tool
nitrate pollution primarily groundwater one major water pollution problems europe last years specially mediterranean areas semi arid zones vulnerable nitrate pollution areas small excess nitrogen produce higher nitrate concentrations humid countries aquifer recharge minor large number bodies jucar river basin district rbd located spain nitrate concentrations water framework directive wfd sets goal good status water bodies european union also implies compliance nitrates directive river basin authorities rbas must define measures needed reach environmental objectives river basin management plans rbmps considering long time lag aquifers decisive measures effectiveness means nitrogen cycle simulation river basin district help monthly distributed patrical model jucar rba defined measures applied exemptions reach objectives relation nitrate pollution model methodology useful river basins define measures total nitrogen inputs jucar rbd amounts year represents nitrogen surplus year pressure kgn year crop around gwbodies currently good status remaining bodies could reach good status following hydrological planning cycles implementation modernized irrigation systems include fertigation use fertilizers water irrigation implementation scenario involves increasing efficiency fertilizer application order reduce nitrogen losses slightly half elsevier rights reserved
automatic detection recognition traffic sign topic great interest advanced driver assistance system enhances vehicle driver safety providing condition state road drivers however visual occlusion ambiguities real world scenario make traffic sign recognition challenging task paper presents automatic traffic sign detection recognition atsdr system involving three modules segmentation detection recognition region interest roi extracted using multiple thresholding schemes novel environmental selection strategy traffic sign detection carried using correlation computation log polar mapped inner regions reference template finally recognition performed using support vector machine svm classifier proposed system achieved recognition accuracy experimental results demonstrates robustness traffic sign detection recognition real world scenario
cisplatin cddp one first line anticancer drugs gained widespread use various forms human malignancies therapeutic outcome cddp therapy limited due adverse effects including myelotoxicity dna damage may lead subsequent risk developing secondary cancer hence search suitable cytoprotectant study investigated probable protective efficacy oxovanadium complex namely oxovanadium cysteine methyl ester complex cddp induced myelosuppression genotoxic damage bone marrow cells swiss albino mice cddp administered intraperitoneally administered orally concomitant pretreatment schedule treatment cddp treated mice significantly enhanced bone marrow cell proliferation inhibited cell death bone marrow niche indicating improvement cddp induced myelotoxicity organovanadium compound also significantly reduced percentage chromosomal aberrations frequency micronuclei formation extent dna damage observed chemoprotective effect attributed anti oxidant efficacy significantly attenuated cddp induced generation free radicals restored levels oxidized reduced glutathione hence may serve promising candidate future development decrease deleterious effects cddp bone marrow cells cancer patients associated secondary complications
web based knowledge database computing platform nonlinear differential equations presented could provide computing graphing based symbolic computing system maple built packages users calculate specific types analytical solutions nonlinear differential systems calling packages also carry symbolic computations associated equations kinds simple computations interactive mode visual output knowledge database differential equations functions general database furthermore equation web page show properties research results addition mathematica formula stored infix form knowledge database displayed visually
rural mexican immigrant women infrequently screened experience health disparities cervical cancer explored cancer related cultural beliefs population administered cross sectional survey mexican immigrant women due screening conducted univariate bivariate analyses participants characteristics pap test history cancer related knowledge beliefs cultural consensus analysis causes cervical cancer barriers screening cultural consensus tasks consensus eigenratios among survey participants comparing rankings risk factor clusters clusters related sexual behaviors ranked severely clusters related genetic behavioral factors agreement ideas cervical cancer causation barriers screening among women hence improved methods disseminating important health information greater access care needed particularly relationship stigma sex birth control practices
aims increases protein kinase pkc oxidative stress related mania drugs antioxidant effects inhibitory actions pkc may antimanic effects flavonoid quercetin antioxidant pkcinhibiting effects resemble lithium first line treatment mania bipolar disorder hypothesized quercetin may antimanic like effects animal model main methods present study investigated effects acute chronic treatment quercetin male swiss mice subjected methylphenidate induced hyperlocomotion animal model mania lithium diazepam used positive negative controls respectively also evaluated effects treatments methylphenidate induced oxidative stress brain measuring reduced glutathione gsh lipid peroxidation lpo levels prefrontal cortex hippocampus striatum key findings acute chronic day treatment lithium diazepam reduced methylphenidateinduced hyperlocomotion chronic acute treatment quercetin blocked methylphenidate induced hyperlocomotion effects lithium quercetin occurred doses alter spontaneous locomotor activity whereas diazepam reduced spontaneous locomotor activity chronic treatment lithium quercetin blocked methylphenidate induced increase lpo levels striatum significance results suggest chronic quercetin treatment antimanic like antioxidant effects thus encouraging studies quercetin putative new antimanic drug elsevier inc rights reserved
nucleic acids responsible storage transfer realization genetic information cell provides correct development functioning organisms dna interaction ligands ensures safety information past years advances electron microscopy image processing allowed obtain structures key dna protein complexes resolution however radiation damage limiting factor potentially attainable resolution cryo prospect limitations studying protein dna complex interactions using cryo electron microscopy discussed reviewed ways minimize radiation damage biological specimens possibilities using radiation damage called bubblegrams obtain additional structural information elsevier ltd rights reserved
last two decades epoxy asphalt seen wide application bond coat binder approximately thick dense graded epoxy asphalt concrete pavement numerous orthotropic bridge steel decks around world particularly east asia bridges paved system include sutong bridge china longest main span cable stayed bridge xihoumen bridge china longest main span suspension bridge new san francisco oakland bay bridge united states however efforts also spent take advantage unique properties epoxy asphalt solve several difficult pavement challenges examples additional applications epoxy asphalt include relatively thin dense graded overlays concrete bridge decks durable open graded surface mixtures concrete bridge decks roadways dense graded mixtures long life roadway pavements paper describes problems faced solved epoxy asphalt surfacings various projects wide spread dense graded wearing courses orthotropic decks discusses potential application epoxy asphalt roadway pavements published elsevier ltd
sexual double standard sds focus research several decades numerous anecdotal accounts double standard exist detailing consequences impact women well men sexual behavior identities empirical research however yet completely corroborate degree double standard pervades everyday life disparity anecdotal accounts empirical evidence related sds may result partially atheoretical approach sds traditionally examined goal present paper encourage researchers take theory oriented approach understanding double standard goal provide another comprehensive literature review argument best theory rather promote theory based perspectives future sds research current paper three theoretical perspectives evolutionary theory social role theory cognitive social learning theory relevance sds discussed discuss four hypotheses one related core tenet sds three related moderating factors including characteristics evaluators gender gender roles beliefs sexual history characteristics targets relationship type engaged sexual activities participated power status social factors cultural background historical era socialization agents existing research also interpreted light one theoretical perspectives hopes guiding future research
cloud computing specialized form distributed computing resources storage processors memory etc completely abstracted consumer number cloud service providers csps offer computing service increased recent times often customers need interact unknown service providers carry transactions open anonymous environments trust helps build consumer confidence provides reliable environment trust based ranking system could also help choose services per requirement paper multi criteria decision making methods used rank service providers based infrastructure parameters combination analytic fuzzy method gives better trust estimate compared analytic method alone
reversible logic various applications fields computer graphics optical information processing quantum computing dna computing ultra low power cmos design communication day day life demanding portable electronic devices challenging focus technology demanding great system performance without compromise power consumption obvious find tradeoff processing power heat generation decreased processing speed leads reduced power consumption obviously compromise performance acceptable sophisticated applications thus power consumption prime target days needless say researchers look reversible logic vein primitive component reversible logic synthesis reversible logic gates thus important new researcher look extensive literature survey reversible logic gates many papers reported review reversible logic gates paper aims updates reversible logic gates stepping stones design synthesis complex reversible logic based synthesis
introduction recent triptan development focused new administration methods formulations triptan combination therapies treatment menstrually related migraines novel serotonin receptor subtype agonists htf areas covered clinical triptan research related migraine reviewed analyzing embase pubmed data bases focus clinical trials class level evidence advances drug combination therapies well administration devices aid ease use increase efficacy decrease adverse reactions new agents devices similar less efficacy compared previous generic triptan formulations new agents action htf receptor subtype avoid vascular side effects classic htb agonists however adverse reactions may limit clinic use long half life triptans frovatriptan naratriptan appear good benefit menstral related migraine expert opinion recent advances triptan development offer advantages migraine therapy patient preferences much higher cost compared individual generic triptan agents coming years triptan advances high efficacy limiting adrs cost welcomed regard htb triptans already well established
hiv central nervous system cns mainly infects microglial cells known express toll like receptors tlrs paper aimed study role soluble tlr stlr stlr inflammatory markers cerebrospinal fluid csf hiv simian immunodeficiency virus siv related neurological sequelae determined stlr stlr levels csf serum plasma siv infected rhesus macaques without neurological sequelae well hiv infected patients without cognitive impairments alzheimer disease patients matched controls csf cytokines chemokines levels analyzed macaques markers neuroinflammation neopterin csf concentrations measured hiv infected patients microglial astrocyte marker respectively found detectable levels stlr stlr csf macaques humans furthermore csf stlr stlr concentrations higher siv infected macaques neurological sequelae compared without neurological complications respectively csf monocyte chemoattractant protein mcp levels elevated macaques neurological sequelae positive correlation found csf levels stlr mcp also humans elevated csf stlr levels found hiv infected patients cognitive impairments compared hiv infected patients normal cognition unlike csf levels neopterin correlated positively stlr stlr difference found plasma csf stlr stlr levels patients control subjects conclusion csf stlr stlr may play role hiv siv related neuroinflammation subsequent neuropathology
study investigates common action looking mobile phone display thereby offering insight present communication situation era use high performance mobile phones become ubiquitous study action looking mobile phone display considered nonverbal behavior communication study applies basic general model elucidate present situation face face communication light increasing prevalence social interaction via mobile phone use results derived model include mobile phone users increasing social power accumulation potential discontent relation different interpretations study concludes era high performance mobile phones social context face face communication influenced act looking mobile phone display author published elsevier ltd
without slighting important role played controlled psychological processes human aggression paper recommends considerable systematic attention also given operation automatic processes bringing behavior concepts automaticity impulsivity discussed briefly proposed many impulsive actions particularly antisocial ones due failures restraint initiated involuntarily number experiments reviewed situational stimuli automatically instigated heightened aggressive inclinations associations hostility displacement reactions stigmatized persons association aggressive reactions media violence last mentioned studies deal especially factors affecting selection target aggression discussing findings suggested crucial situational features automatically initiated sequence determinants aggression displayed could due either hostile appraisal target activation aggression related bodily reactions well hostile ideas also hypothesized least one studies experienced negative affect might instigated aggression independently appraisals
terms theories techniques network security packet capture protocol analysis branch network security protocols depend widely used insecure protocols present day paper mainly discusses capture analysis network packets subsequently designs capture program network packets meanwhile working principle internal structure function libraries captured bpf based packets namely libpcap winpcap analyzed carefully detailed analysis elementary implement principles methods approaches current capture analysis system network packets describing hiberarchy capture analysis system network packets specific design implement methods packet capturing analyzing system winpcap proposedin end paper states predicts directions implement methods network data monitoring analyzing
objective impact treatment method surgical clipping endovascular coiling cost care patients aneurysmal subarachnoid hemorrhage sah debated authors investigated association treatment method long term medicare expenditures elderly patients aneurysmal sah methods authors performed cohort study medicare fee service claims data elderly patients undergone treatment ruptured cerebral aneurysms period control measured confounding authors used propensity score adjusted multivariable regression analysis mixed effects account clustering hospital referral region hrr level instrumental variable regional rates coiling analysis used control unmeasured confounding creating pseudo randomization treatment method results study period patients underwent treatment ruptured cerebral aneurysms met inclusion criteria patients surgical clipping endovascular coiling median total medicare expenditures year admission sah iqr surgical clipping iqr endovascular coiling authors adjusted unmeasured confounders using instrumental variable analysis clipping associated increased year medicare expenditures conclusions cohort medicare patients aneurysmal sah controlling unmeasured confounding surgical clipping associated increased year expenditures comparison endovascular coiling
using data three national surveys present research investigates among native dutch studies three immigrant origin groups study endorsement shared sense national belonging across cultural differences endorsement examined relation political orientation education sociocultural deprovincialization egalitarian autochthony beliefs three studies right wing orientation lower education associated lower endorsement common national belonging furthermore deprovincialization autochthony independent mediating beliefs associations findings similar native majority members immigrants exception role autochthony belief results discussed relation future research cultural diversity societal importance developing shared sense belonging despite group differences
present work focuses reducing dropout voltage noise exploiting unique advantages complementary silicon germanium sige heterojunction bipolar transistor sige hbt soi technology also explore impact utilizing different pnp device types regulator performance design challenges arose chip load capacitor required meet specification instantaneous peak output voltage drop overcome challenges right hand plane rhp left hand plane lhp zero conversion technique nulling miller resistor applied complete solutions locations converted left hand plane zero miller pole affected nulling resistor derived utilizing signal flow graphs without assumptions commonly made literature two sige ldo regulators two different types pnp output devices fabricated utilizing commercially available sige soi technology compared literature
metabolomics shown effective tool disease diagnosis biomarker screening characterization biological pathways total subjects included study urine metabolomes patients liver cirrhosis patients hepatocellular carcinoma hcc healthy male subjects control group studied gas chromatography mass spectrometry based urine metabolomics profiles investigated participants diagnostic models constructed combination marker metabolites using principal components analysis receiver operator characteristic curves total peaks could auto identified marker metabolites glycine serine threonine proline urea phosphate pyrimidine arabinose xylitol hippuric acid citric acid xylonic acid glycerol responsible separation hcc group healthy subjects also eight markers metabolites glycine serine threonine proline citric acid urea xylitol arabinose showed significant differences group healthy subjects significant difference detected hcc groups regarding metabolites metabolomic profile using established optimized diagnostic model discriminate hcc patients healthy subjects also could useful diagnosis patients however failed differentiate hcc patients
article presents overview nonaccidental trauma children including common clinical presentation evaluation diagnosis
context global software industry software engineering academia two large communities however unfortunately level joint industry academia collaborations still relatively low compared amount activity two communities seems two camps show limited interest motivation collaborate one many researchers practitioners written challenges success patterns collaborate anti patterns industry academia collaborations objective identify challenges avoid risks collaboration aware challenges best practices provide inventory practices patterns allowing informed choice practices use planning conducting collaborative projects method systematic review conducted synthesis done using grounded theory based coding procedures results thematic analysis identified challenge themes best practice themes key outcome inventory best practices common ones recommended different contexts hold regular workshops seminars industry assure continuous learning industry academic sides ensure management engagement need champion basing research real world problems showing explicit benefits industry partner agile collaboration location researcher industry side conclusion given importance industry academia collaboration conduct research high practical relevance provide synthesis challenges best practices used researchers practitioners make informed decisions structure collaborations elsevier rights reserved
background local tumour ablation lta may yield better perioperative outcomes partial nephrectomy however impact treatment perioperative mortality health care expenditures unknown aim study compare mortality morbidity health care expenditures lta patients methods population based assessment patients ctla kidney cancer treated either lta seer medicare database performed propensity score matching day mortality overall specific complication rates length stay readmission rates health care expenditures according lta estimated multivariable logistic linear models addressed effect specific lta approach overall complication rates length stay readmission rates health care expenditures results day mortality either lta overall complication rate lta blood transfusions infection sepsis wound infections respiratory complications gastrointestinal complications acute kidney injury accidental puncture laceration foreign body left procedure rates resulted lower lta relative similarly length stay health care expenditures resulted lower lta relative conversely readmission rate significantly different lta relative conclusions despite similar perioperative mortality lta associated lower complications rate shorter length stay lower health care expenditure relative elsevier ltd baso association cancer surgery european society surgical oncology rights reserved
purpose evaluate changes nocturia surgical correction obstructive sleep apnea osa methods total patients included present study diagnosed osa syndrome polysomnography underwent uvulopalatopharyngoplasty uppp preoperative postoperative lower urinary tract symptoms luts quality life qol nocturia episodes evaluated using international prostate symptom score ipss overactive bladder symptom score oabss questionnaires three months postoperatively telephone interviews performed determine success surgery current luts nocturia episodes patients divided surgical success failure groups surgical success defined snoring decrease based patient subjective judgment results response rate success rate patients nocturia episodes significantly decreased mean ipss score oabss score qol scores also significantly improved success group showed significant decrease nocturia episodes total ipss oabss qol scores however failure group show significant changes parameters conclusions osa correction improved nocturia well luts improvements observed failure group study shows osa cause nocturia luts nocturia improved surgical correction osa
infrastructure service desktops diaas based extensible mark language xml herein proposed utilize surplus resources diaas traditional surplus resource integrated management technology designed provide fast work distribution computing services based user service requests well storage services desktop based distributed computing storage resource integration diaas includes nondisruptive resource service auto scalable scheme enhance availability scalability intra cloud computing resources performance evaluation proposed scheme measured clustering performance time surplus resource utilization results showed improvement computing storage services connection least two computers compared traditional method high availability measurement nondisruptive services furthermore artificial server error environment used create clustering delay computing storage services nondisruptive services compared hadoop distributed file system hdfs
aim investigated associations clinical high risk psychosis chr psychotic like symptoms suicidality among adolescent psychiatric patients methods sample consisted chr non chr psychiatric patients aged helsinki finland assessed beginning psychiatric treatment structured interview prodromal syndromes sips current suicidality measured beck depression inventory item lifetime suicidality evaluated available data including patient files participants followed years via national hospital discharge register follow outcome intentional self harm data suicides also gathered causes death statistics results adolescents suicidal ideation beginning treatment chr risk state sips assessed delusions suspiciousness hallucinations associated higher current suicidality adolescents register follow five intentional self harm resulting hospital treatment female chr status associated self harm current suicidality familial risk psychosis sips decreased expression emotions associated self harm follow cox regression analysis model among girls decreased expression emotions remained significant predictor intentional self harm baseline suicidality measures associated transitions psychosis conclusions chr status associated higher current suicidality predict follow intentional self harm treatment seeking adolescents decreased expression emotions may indicate higher risk intentional self harm adolescent treatment seeking girls
older adults harder time younger adults remembering specific events experiences episodic memory whereas ability use one general knowledge either improves remains stable life span focus sometimes overlooked critical possibility intact general knowledge facilitate older adults episodic memory performance reviewing literature shows prior knowledge support remembering aging well lead astray consider open questions including whether prior knowledge used fill gaps memory failure older adults might need instructed apply prior knowledge overall situate claims within theories cognitive aging arguing prior knowledge key factor understanding older adults memory performance potential serve compensatory mechanism
paper alternative method based artificial neural networks presented determine harmonic components load current single phase electric power system nonlinear loads whose parameters vary much reason loads characteristic behaviors human intervention first six components load current determined using information contained time varying waveforms effectiveness method verified using single phase active power filter selective compensation current drained controller proposed method compared fast fourier transform
work macroscopic non linear constitutive model accounting damage inelastic strain unilateral behavior proposed plain woven sic composite set scalar damage variables new thermodynamic potential expression introduced framework continuum damage mechanics deduced constitutive equations material progressive damage deactivation behavior compression loading described continuous function different deactivation rates uniaxial biaxial compression loadings also considered damage evolution laws coupling effect among damage modes impediment effect compression stress development shear damage different plane stress states taken account besides general plasticity theory applied describing evolution inelastic strain tension shear stress state tsai failure criterion adopted strength analysis additionally material model implemented user defined material subroutine umat linked abaqus finite element software performance demonstrated several numerical examples production hosting elsevier ltd behalf csaa buaa
objectives cardiovascular risk estimated several scores patients diabetes mellitus without cardiovascular disease history association carotid atherosclerotic plaque cap aims study materials methods cardiovascular risk calculate using united kingdom prospective diabetes study ukpds risk engine framingham risk score cardiovascular fscv coronary disease fscd new score proposed acc aha guideline treatment blood cholesterol ultrasound used assess cap occurrence receiver operating characteristic roc analysis performed results one hundred seventy patients mean age years men included average fscv fscd values respectively according ukpds score average risk coronary disease stroke respectively comparing risks estimated different scores significant correlation found prevalence cap patients higher scores prevalence increased roc analysis showed good discrimination power subjects without cap conclusion cardiovascular risk estimated high heterogenic prevalence cap increased according strata risk understanding relationship cap scores could improve risk estimation subjects diabetes
analyze quantitatively interface core shell structural bamboo plastic composites bpcs surface relationship microstructure composite surface macroscopic impact performance investigated effect shell layer interface impact strength core shell bpcs studied scanning electron microscope sem images computer image processing technique fractal theory fractal dimensions core shell bpcs calculated relationship measured impact strength fractal dimensions core shell bpcs fracture surface discussed results showed fractal dimensions interface fracture surface within range respectively correlative coefficients higher therefore strong linear correlation indicated fractal characterization interface impact fracture surface bpcs possible also proved interface could analyzed quantitatively depending feature parameters fractal dimension relationship fractal dimension measured impact strength linear bigger fractal dimension surface bigger impact strength stronger interfacial bond thus using fractal dimensions surface morphology core shell structural bpcs described may provide new approach investigate inherent rules fractal characteristics charpy impact strength bpcs core shell structure
genes bacteria immunity contribute pathogenesis inflammatory bowel disease genetic risk relates defective sensing microbes metabolites defective regulation host response microbiota composition microbiota shapes developing immune system determined early life prospect therapeutic manipulation microbiota adulthood onset disease questionable however microbiota may marker risk modifier disease activity contributor extraintestinal manifestations associations patients inflammatory bowel disease
context children living slums high risk malnourished published reviews existing interventions promoting better nutrition children living slums risk factors children malnutrition improved understanding risk factors malnutrition slums communities impact interventions children health provide guidance practitioners decision makers present review designed provide information methods search included electronic bibliographic databases relevant eligible studies published december results search located citations full text relevance screening conducted studies abstracts studies final unique studies included interventions risk interventions nutrition specific nutritional intervention dominant type seventy three per cent interventions assessed effective conclusion findings stressed gaps knowledge terms quality assessment programmatic recommendations identify children risk malnutrition appropriately target interventions finally review helped inform systematic review cochrane systematic review protocol examine impact interventions outcome measures
present work detailed simulation using technology computer aided design tcad tool silvaco non irradiated irradiated lgad low gain avalanche detector devices carried effects different design parameters proton irradiation lgad operation discussed detail already published effective two trap bulk damage model used simulate radiation damage without implementing acceptor removal term tcad simulation irradiated lgad devices produce decreasing gain increasing fluence similar measurement results space charge density electric field distribution used illustrate possible reasons degradation gain irradiated lgad devices elsevier rights reserved
given time critical contextual variable organizations effectiveness indicators rarely exclude timeliness argue temporal individual differences unfortunate omission implicit leadership theories ilts implicit followership theories ifts implicit theories time based individual differences commonly undiscussed subtle effects manifest explicitly behaviors consequences real implications leaders followers organizations therefore conceptual paper draw attention time patience extent individuals unconcerned unfocused deadlines passage time time perspective relative importance past present future events ongoing thought processes decision making polychronicity preference multitasking pacing style manner individuals distribute effort time working toward deadlines neglected research worthy components followers ilts leaders ifts infusing time related characteristics leadership research consider content structure temporal ilts ifts also draw attention potential inconsistency leaders temporal ifts followers actual behaviors well followers temporal ilts leaders actual behaviors offer propositions prescriptive value specifying conditions temporal ilt ift inconsistency less detrimental leader follower coordination elsevier inc rights reserved
transgenerational patterns child rearing practices implicated maintenance psychosocial problems across generations understanding patterns important aim research developmental psychology decades recently suggested individuals current parenting practices strongly influenced early maladaptive schemata thought arise childhood experiences caregivers context family interventions increasing parental mindfulness proposed reduce effects schemata however currently research testing possible interrelationships among variables community samples first aim current study therefore test associations parents perceptions aversive childhood experiences caregivers extent early maladaptive schemata current level perceived parenting competence second aim explore whether parents level mindfulness moderating mediating relationship community sample parents completed packet self report questionnaires results path analyses indicated participants early maladaptive schemata mediated relationship perception childhood experiences caregivers current sense parental competence furthermore stronger early maladaptive schemata related lower levels mindfulness turn associated lower levels parental competence results provide important initial step towards exploring potential role mindfulness intergenerational transmission parenting practices community
objective examine effects levonorgestrel releasing intrauterine device lid patients female sexual dysfunction using device contraception study design results device application month follow compared using female sexual function index fsfi test sample patients female sexual dysfunction requested use lid contraception results fsfi scores placement lid month follow determined respectively addition visual analog scale scores menstruation duration determined statistically significantly different placement fsfi subgroup evaluations performed desire arousal parameters application determined statistically significantly different conclusion use lid contraception resulted positive effects patients female sexual dysfunction
properly designed alarm systems benefit operators conducting routine emergency tasks digitization main control rooms alarm interface designed various ways different traditional alarm tile style innovative alarm bar interface proposed paper preliminary lab experiment conducted compare traditional alarm tile new alarm bar interfaces sixteen university students recruited participate experiment two emergency scenarios loss coolant accident steam generator tube rupture tested experiment task included two parts alarm detection identification subjective ratings supported innovative alarm bar design better parameter trend perception objective performance measures showed simpler design alarm tile interface better aided alarm detection performance whereas alarm bar interface almost alarm identification performance alarm tile interface relevance industry alarm system critical complex industrial system experimental results show design evaluation complex may seem although proved overwhelmingly superior tile design alarm bar design shows promise aiding operators needs validated elsevier rights reserved
oophorectomy adult rats affected cardiac mitochondrial function progression mitochondrial alterations assessed one two three months surgery one month slight changes observed increased two three months gradual effects included decrease rates oxygen consumption respiratory uncoupling presence complex substrates well compromised buffering ability malondialdehyde concentration increased whereas ros detoxifying enzyme superoxide dismutase mnsod aconitase lost activity mitochondrial respiratory chain concentration activity complex complex decreased among mitochondrial enzymes transporters adenine nucleotide carrier glutaminase decreased oxoglutarate dehydrogenase pyruvate dehydrogenase also decreased data strongly suggest female rat heart estrogen depletion leads progressive severe mitochondria dysfunction
cultivate students capacity computational thinking educational process computer programming one basic goals computer basic education considering generally reflected problems education programming courses boring enthusiastic learning grammatical structures teaching cases dispersed etc paper introduces gamified educational mode purpose cultivate students capacity computational thinking educational model based gamified education constructed cultivation gamified education students computational thinking ability analyzed specific case analysis gamified educational mode effectively stimulates students motivation interest learning cultivate students self learning ability better tap abstract algorithm thinking cultivate students computational thinking capacity
schizophrenia chronic debilitating neuropsychiatric disorder affects population dystrobrevin binding protein dtnbp dysbindin one research domain constructs rdoc associated cognition significantly reduced brain schizophrenia patients understand molecular underpinnings pathogenesis schizophrenia performed microarray analyses hippocampi dysbindin knockout mice found genes involved lipogenic pathway suppressed moreover discovered maturation master transcriptional regulator lipid synthesis sterol regulatory element binding protein srebp induced neuronal activity required induction immediate early gene arc activity regulated cytoskeleton associated protein necessary synaptic plasticity memory found nuclear srebp dramatically reduced dysbindin knockout mice postmortem brain tissues human patients schizophrenia furthermore activity dependent maturation srebp well arc expression attenuated dysbindin knockout mice deficits restored atypical antipsychotic drug clozapine together results indicate important role dysbindin neuronal activity induced srebp arc could related cognitive deficits schizophrenia
practice teaching important way cultivate senior specialists innovative spirit practical ability paper combines present metal materials engineering chongqing university science technology puts forward suggestions improving staff teaching optimiaing course setting improving system four years uninterrupted teaching content strengthening construction laboratory practise base following way combination production teaching research put forward suggestions achieve goal training applied talents metal material engineering
paper propose generalized state space hedging method use populations associated hedging instruments liability hedged different method hedging strategy derived first reformulating assumed multi population stochastic mortality model state space representation considering sensitivities hedge portfolio liability hedged relevant hidden states inter alia method allows decompose underlying longevity risk components arising solely hidden states shared populations components stemming exclusively hidden states population specific latter components collectively represent explicit measure population basis risk involved measure infer portion population basis risk depends longevity hedge constructed another portion exists matter notional amounts hedging instruments present proposed hedging method static dynamic settings elsevier rights reserved
background changes platelet indices reported patients panic disorder however previous study findings contradictory inconclusive aim study evaluate compare platelet indices patients materials methods patients healthy controls enrolled case control study platelet indices mean platelet volume mpv platelet distribution width pdw along red blood cell rbc indices rbc count red cell distribution width rdw compared two groups using unpaired test results patients lower mpv higher pdw higher platelet count healthy controls furthermore significant differences patients healthy controls terms rbc count rdw conclusion patients increased pdw rdw platelet rbc indices may prove useful etiological prognostic markers patients
international working group iwg classified alzheimer disease two different types typical form atypical form clinicopathological studies atypical limited atypical cases usually present early onset dementia investigated patients early onset including two patients typical patients atypical patients six posterior variant three frontal variant one logopenic variant mixed semantic dementia reported mri single photon emission neuropathological findings six representative cases also described left temporal variant presenting transcortical cortical sensory aphasia reported previously another subtype posterior variant found significant correlation regional cerebral blood flow counts nfts cerebral cortices atypical presentation focal neuropsychological symptoms roughly correlated density nfts cerebral cortex directly related spongiform changes superficial layers areas contrast distribution amyloid depositions diffuse necessarily correlate focal neuropsychological symptoms braak staging abc score necessarily appropriate evaluate atypical instead spongiform changes addition tau pathology association cortices better explain diversity atypical interestingly another patient posterior variant novel type atypical plaque referred lucent plaque recognizable staining circumference dystrophic neurites abundant gallyas braak staining plaques demonstrated intense immunoreactivity tau amyloid beta beta suggesting peculiar coexistence pattern amyloid tau plaques clinicopathological studies atypical provide new understanding pathophysiology
plasmablastic lymphoma rare aggressive cell lymphoma considered strongly associated hiv infection article explores histological morphology immunohistochemical characteristics hiv aids related plasmablastic lymphoma goal improving diagnosis treatment rare tumor according criteria theworld health organization classification tumors hematopoietic lymphoid tissues six plasmablastic lymphoma cases admitted shanghai public health clinical center comprehensively analyzed conventional hematoxylin eosin staining immunohistochemical staining situ hybridization morphological features six tumors consistent pbl immunohistochemical staining showed six cases negative cda positive oct bob vsc melanoma ubiquitous mutated proliferation index higher six cases situ hybridization indicated four cases eber positive addition three cases myc translocation rearrangement results showed immunophenotypes pbl vary makes pbl diagnosis difficult therefore morphological characteristics immunophenotypic markers clinical data used combination enable accurate diagnosis especially presence immunophenotypic variation approach facilitate timely treatment
world presently confronted twin crisis fossil fuel depletion environmental degradation indiscriminate extraction lavish consumption fossil fuels led reduction underground based carbon resources search alternative fuel promises harmonious correlation sustainable development energy conservation management efficiency environmental preservation become highly pronounced present context developing countries world fuels bio origin provide feasible solution crisis present investigation hydrogen enriched air used intake charge compression ignition engine experiments conducted single cylinder four stroke air cooled stationary direct injection diesel engine kirlosker taf rpm capacity coupled electrical generator injection timings degrees flow rates hydrogen varied find optimum condition hydrogen enrichment meet best performance experiment results showed hydrogen enriched engine gave maximum brake thermal efficiency minimum brake specific energy consumption flow rate injection timing elsevier ltd rights reserved
paper serial parallel hybrid sph power system formed fuel cell auxiliary storage device asd current controlled converters responsible power management realized using digital signal controller dsc tmsf main energy management goal transfer energy sources asd load ensuring bus voltage regulation high power conversion efficiency addition safe reliable operation system achieved selected converter controller features noninverting voltage step step high efficiency regulation input output currents low ripple values ability change input output current regulation loop suddenly smoothly vice versa features allow positioned different system localizations simplify design master control simulation experimental results validated bus
non osteoporotic postmenopausal women breast cancer aromatase inhibitors ais negatively affected bone mineral density bmd lumbar spine trabecular bone score tbs bone microarchitecture index hip geometry bone macroarchitecture index ais increase risk fracture patients breast cancer therefore aimed evaluate long term skeletal effects ais postmenopausal women primary breast cancer performed retrospective longitudinal observational study non osteoporotic patients breast cancer treated ais years score patients previous anti osteoporosis treatment given bisphosphonate treatment excluded analysis serially assessed bmd lumbar spine tbs hip geometry using dual energy ray absorptiometry bmd significantly decreased baseline years lumbar spine femur neck total hip lumbar spine tbs also significantly decreased baseline years change remained significant adjusting lumbar spine bmd annual loss lumbar spine bmd tbs slowed year treatment respectively although relatively constant loss bmd femur neck total hip years cross sectional area cross sectional moment inertia minimal neck width femur strength index section modulus significantly decreased although buckling ratio increased treatment period changes independent total hip bmd long term adjuvant treatment negatively influenced bone quality addition bmd patients breast cancer study suggests early monitoring management needed non osteoporotic patients breast cancer starting ais
order overcome defects traditional methods measuring plant leaf diseases achieve accurate detection blade relative lesion area clustering algorithm improved clustering algorithm used calculate leaf relative lesion area knowledge computer graphics technology first preprocess image selectively image correction color space conversion technology use clustering algorithm divide target area finally calculate relative lesion area according partition determined objective function paper proposed improved genetic algorithm improve limitation problem selecting clustering algorithm initial value enhance searching capability robustness original algorithm improving genetic operator genetic algorithm considering accuracy image processing quota results show algorithm paper makes lesion area calculated clustering center accurate lays effective theoretical foundation diagnosis crop diseases insects level
infants begin help individuals second year life however still unclear whether early helping behavior based understanding individuals needs thus motivated prosocially present eye tracking study month old infants saw character need help unable reach goal obstacle second character able achieve goal third individual helper initiated action infants expected helper help character need indicated anticipatory looking violation expectation phases prosocial understanding differ age groups related helping behavior measured two behavioral tasks thus infants understand individuals needs even start help others indicates early helping may indeed motivated prosocially raises question competences underlie ontogeny helping behavior
mammals short photoperiod associated high depression anxiety like behaviours low levels brain serotonin precursor tryptophan trp brain trp levels regulated ratio large neutral amino acids trp lnaa circulation study elucidated whether diets various protein sources contain different trp lnaa affect depression anxiety like behaviours cbl mice short day conditions control mice casein diet time spent central area open field test oft lower mice long day conditions indicating exposure induces anxiety like behaviour induced anxiety like behaviour countered lactalbumin diet given mice gluten diet transition time spent central area oft higher control mice alternatively mice ingested soya protein transition lower immobility forced swim test depression like behaviour compared control analysis trp lnaa revealed lower trp lnaa control compared control counteracted lactalbumin diet furthermore mice gluten soya protein diets transition exhibited high trp lnaa levels plasma conclusion ingestion specific proteins different times relative photoperiodic transition may modulate anxiety depression like behaviours partially changes plasma trp lnaa
purpose cognitive behavioral stress management cbsm empirically validated group based psychosocial intervention cbsm related decreased self reported indicators psychological adversity breast cancer treatment greater disease free survival dfs control condition study examined relationships cbsm dfs potential biobehavioral pathway linking variables breast cancer patients gene expression composite representing leukocyte conserved transcriptional response adversity ctra design women stage iiib breast cancer completed questionnaires provided blood samples post surgery participants randomized week group based cbsm psychoeducation control group followed months months median years total participants provided blood data longitudinal analyses cbsm control mixed model analyses examined cbsm effects month changes ctra expression indicator genes representing pro inflammatory anti viral antibody production signaling cox regression models assessed relationship month changes ctra expression year dfs results patients randomized cbsm showed attenuated month change ctra gene expression whereas patients randomized control showed increased ctra expression average dfs years greater month ctra increases predicted shorter year dfs controlling covariates conclusions cbsm attenuated ctra gene expression initial year breast cancer treatment turn greater increases ctra gene expression predicted shorter long term dfs findings identify biobehavioral oncology pathway examine future work elsevier ltd rights reserved
beta hydroxysteroid dehydrogenase type deficiency rare autosomal recessive cause disorder sex development worldwide mutations hydroxysteroid beta dehydrogenase hsdb gene reported involving exons except exon herein investigated egyptian female karyotype low testosterone delta androstenedione ratio genomic dna extracted blood samples direct dna sequencing hsdb gene performed patient homozygous mutation exon resulting stop codon study presents first mutation reported exon hsdb gene copyright karger basel
psychological models forming impressions people assume process strictly connected social categorization therefore clear results many studies show evaluations people based two crucial separable criteria morality competence obviously morality competence two fundamental distinct dimensions perception politicians dimensions substantially influence voters behavior toward politicians clearly visible preelection polls well scientific analyses concerning forming images politicians evaluations politicians morality competence dimensions central forming interpersonal attitudes dominant elements affect respect toward evaluated person consequently affect respect crucial factors establishing support candidates political offices morality competence dimensions trigger causal structures voter mind formed attitude creates affect respect determine voting behavior
covert channel network protocols area absorbing great interests many years secret transmission recently covert channels based packet length become new preference among researchers field excellent performance simulating statistical features network packets real world however approaches embed secret information great security ensured worked far therefore paper analyze traffic stream udp packets several storage features data files propose novel network steganography scheme based address udp packet length order overcome drawbacks existing schemes comprehensive set corresponding experiment results show proposed covert channel follows normal traffic statistical features well thus ensures security existing algorithms
coordinated access care homeless people catch program brief multidisciplinary case management intervention homeless adults discharged hospital toronto canada describe rationale catch program development details mixed methods evaluation underway characteristics catch service users funded local health authority catch aimed improve access continuity care health service use outcomes homeless adults discharged hospital assess feasibility acceptability impact program mixed methods case study undertaken total catch program users enrolled study completed quantitative survey measures program entry assess key health social outcomes using pre post cohort study design follow assessments took place months study entry participants male white canadian born single never married average age years nearly participants least one emergency department visit past months half indicated least three chronic health conditions indicated least three mental health diagnoses addition qualitative data collected evaluate experiences continuity care challenges care transitions population using depth interviews sample catch service users managers partnered organizations well focus groups catch staff service providers people lived experience homelessness improving health health service use outcomes among homeless adults chronic health conditions key priorities many jurisdictions future findings inform service delivery homeless adults discharged hospital exposing factors associated positive program outcomes well barriers facilitators continuity care disadvantaged population
prenatal maternal distress associated risk developmental profile yet little fetal evidence putative utero process moreover biological transmission maternal effects remains uncertain study pregnant adolescents ages ambulatory assessments daily negative mood anger frustration irritation stress physical activity blood pressure heart rate every min salivary cortisol six samples collected gestational weeks corticotropin releasing hormone reactive protein interleukin blood draws min assessments fetal heart rate fhr movement acquired latter two sessions average fetuses showed development expected direction decrease fhr increase fhr correlation movement fhr coupling maternal distress characteristics associated variations level trajectory fetal measures results often differed sex males greater maternal session negative mood session physical activity associated lower overall fhr session cortisol associated smaller increase coupling overall higher levels findings suggesting accelerated development females negative mood cortisol diastolic blood pressure associated indications relatively less advanced accelerated outcomes associations negative mood biological variables data indicate maternal psychobiological status influences fetal development females possibly variously responsive different exposures wiley periodicals inc dev psychobiol
atmospheric water vapor plays important role hydrologic cycle climate change earth number studies focused retrieval total precipitable water tpw using microwave optical remote sensing paper global quarter degree gridded tpw land retrieved using water vapor sensitivity parameter delta delta based combination amsr modis observations two major improvements retrieval algorithm including optimization estimation model surface emissivity delta epsilon delta epsilon correction terrain influence retrieval tpw using dem obtain high resolution tpw also developed algorithm downscale retrieved quarter degree gridded tpw fine scale degrees degrees using dem ndvi addition downscaled tpw calibrated using high precision tpw modis clear sky condition improve accuracy finally quarter degree degrees degrees gridded tpw validated suominet gps retrieved tpw global scale rmse retrieved quarter degree gridded global tpw correlation coefficient addition rmse downscaled degrees degrees gridded global tpw correlation coefficient obvious advantage algorithm compared modis tpw product retrieve tpw cloudy sky condition land algorithm developed study easily transferred amsr board gcom provides long term global daily tpw land since launch aqua present day support hydrologic cycle climate change studies elsevier inc rights reserved
optimization operating time relay interconnected network essential reduce damage reducing fault clearing time time enhance selectivity relay employing directional feature relays connected network function properly normal well abnormal condition prime feature paper obtain minimum time dial setting tds relays considered network using firefly algorithm said algorithm result compared linear programming technique implementation network simulated matlab unprecedented feature paper application nature inspired algorithm one important problem optimization field power system protection
thyroid function known influence glucose metabolism thyroid stimulating hormone useful parameter screening thyroid dysfunction therefore aim study investigate incidence type diabetes according baseline thyroid stimulating hormone level thyroid stimulating hormone change euthyroid subjects identified enrolled euthyroid subjects without diabetes among participants undergone consecutive thyroid function tests part yearly health check program thyroid stimulating hormone changes determined subtracting baseline thyroid stimulating hormone level thyroid stimulating hormone level year diagnosis diabetes end follow subjects develope diabetes person years follow new cases type diabetes cox proportional hazards models showed risk incident type diabetes significantly increased increment tsh adjustment multiple confounding factors hazard ratio confidence interval compared individuals lowest tertile highest thyroid stimulating hormone change tertile greater risk incident type diabetes hazard ratio confidence interval trend however baseline thyroid stimulating hormone level tertile associated risk diabetes prominent increase thyroid stimulating hormone concentration additional risk factor development type diabetes euthyroid subjects
contraception pillar reducing adolescent pregnancy rates american academy pediatrics recommends pediatricians develop working knowledge contraception help adolescents reduce risks negative health consequences related unintended pregnancy past years number new contraceptive methods become available adolescents newer guidance issued existing contraceptive methods evidence base contraception special populations adolescents disabilities obese recipients solid organ transplants hiv infected expanded academy addressed contraception since policy statement updates statement contraception adolescents provides pediatrician description rationale best practices counseling prescribing contraception adolescents supported accompanying technical report
aims research suggests specialised lighting design essential cater elderly users building reduced visual performance increased age review aims document known physical psychological aspects lighting role promoting healthy safe environment elderly methods methodical review carried published literature physical psychological impacts light elderly design standards guides professional organizations evaluated identify synergies gaps evidence base current practice results lighting identified significant environmental attribute responsible promoting physical mental health elderly evidence related visual performance found robust however guides standards appeared focused mostly illumination requirements specific tasks lacked detailed guidelines vertical lighting luminance design review identified growing body evidence therapeutic benefits lighting use treating psychological disorders among elderly experiments using light therapy improved understanding underlying principles integration therapeutic aspects lighting design practice guidelines lacking conclusions design guidelines discuss physical needs lighting elderly fairly well lack incorporation photobiological impacts despite positive outcomes research implementation therapeutic aspects lighting buildings still debatable due insufficient relevant investigations robustness findings collaborations designers physicians contribute delivering customised lighting solutions considering disease types needs investigation needs carried translating therapeutic benefits photometric units implement building lighting design
paper analyses contribution biological geotextiles gully stabilization urban area luis city sacav district biological geotextile mats constructed palm leaves sacav gully rehabilitation included following techniques installation buriti geotextiles association barriers wooden stakes construction contoured terraces analysis sediment particle size photograph comparison development vegetal cover rehabilitation used similar grass seeds brachiaria decumbens slopes combination geotextiles besides recuperating degraded area income generated poor people live around sacav gully either producing geotextiles applying soil together grass seeds lime npk improve soil properties
plant flavonoid isoliquiritigenin isl botanical estrogen widely taken herbal supplement ease symptoms menopause isl also shown anti tumor properties number cancer cell backgrounds however effects isl normal cells less well known virtually unstudied context pituitary gland established pituitary explant culture model screen chemical agents gene expression changes within pituitary gland period active proliferation differentiation using whole organ culture system found isl weakly estrogenic based ability induce cckar mrna expression estrogen receptor mediated gene using range isl discovered isl promoted cell proliferation low concentration yet potently inhibited proliferation highest concentration ici failed antagonize isl repression pituitary cell proliferation indicating effect independent signaling coincident decrease proliferating cells observed regulation transcript cyclin strong induction mrna protein cyclin dependent kinase inhibitor cdkna importantly high dose isl alter balance progenitor differentiated cell types within pituitary explants seemed otherwise healthy however tunel staining revealed increase apoptotic cell death isl treated cultures results merit examination isl anti tumor agent pituitary gland elsevier inc rights reserved
color image segmentation crucial step many computer vision pattern recognition applications paper introduces adaptive unsupervised approach based vorondi regions solve color image segmentation problem proposed method uses hybrid spatial feature space dirichlet tessellation followed inter vorondi region proximal cluster merging automatically find number clusters cluster centroids image since voronoi regions much smaller compared whole image vorondi region wise clustering improves efficiency accuracy number clusters cluster centroid estimation process proposed method compared four adaptive unsupervised cluster based image segmentation algorithms three image segmentation evaluation benchmarks experimental results reported paper confirm proposed method outperforms existing algorithms terms image segmentation quality results much lower average execution time per image
medical professionals relying social media platforms like twitter express recommendations use avoidance products like electronic cigarettes cigs may long term health consequences users goal study compare physicians united states united kingdom talk cigs twitter identify topics groups perceive salient comparing tweets allow better understanding medical professionals countries differ attitudes toward cigs information also used inform policies designed regulate use cigs using text mining program analyzed approximately original tweets sent physicians within year time span june june program clustered tweets topics allowed categorize topics importance sets tweets contained debates degree cigs pose threat health tweets emphasized dangers cig use teens tweets focused potential cigs used smoking cessation aid doctors using twitter share timely information potential risks benefits regulations associated cigs evaluating tweets allows researchers collect information topics doctors find important make comparisons medical professionals regard cigs
background cost effective reconstruction resection bone sarcoma unknown goal study compare cost effectiveness osteoarticular allograft endoprosthetic reconstruction proximal tibia distal femur methods markov model used revision complication rates taken existing studies costs based medicare reimbursement rates implant prices health state utilities derived health utilities index survey additional assumptions incremental cost effectiveness ratios icer used less per quality adjusted life year qaly considered cost effective sensitivity analyses performed comparison range costs utilities complication rates revisions rates results osteoarticular allografts price discounted endoprosthesis cost effective icers one way sensitivity analysis revealed discounted endoprostheses favored allografts cost endoprostheses cost less allograft reconstruction favored discounted endoprosthetic reconstruction allograft complication rate less allografts cost effective full price endoprostheses conclusions osteoarticular allografts price discounted endoprosthetic reconstructions cost effective sensitivity analysis using plausible complication revision rates favored use discounted endoprostheses allografts allografts cost effective full price endoprostheses
century genetic arguments existence racial inequality used oppose policies promote social equality time period american biology textbooks repeatedly discussed genetic differences races experiment tests whether racial terminology biology curriculum causes adolescents develop genetic beliefs racial difference thereby affecting prejudice individual students grades randomly assigned within classrooms learn either four text based lessons discussing racial differences skeletal structure prevalence genetic disease racial condition identical curriculum lacking racial terminology nonracial condition months coincided learning students racial condition grew significantly perception amount genetic variation races relative students nonracial condition furthermore racial condition grew belief races differ intelligence genetic reasons significantly nonracial condition compared nonracial condition students racial condition became significantly less interested socializing across racial lines less supportive policies reduce racial inequality education findings show biology education sustains racial inequality conversely human genetic variation education could designed reduce genetically based racism wiley periodicals inc
core components hippo signaling pathway cascade kinases govern phosphorylation downstream transcriptional activators namely yes associated protein yap domain containing transcription regulator protein wwtr also known taz hippo signaling pathway considered important tumor suppressor pathway dysregulation noted variety human cancers yap wwtr enable cancerous cells overcome contact inhibition grow spread uncontrollably interestingly however recent studies told somewhat different perhaps intriguing yap wwtr story studies found yap wwtr function central hub integrates signals multiple upstream signaling pathways cell cell interactions mechanical forces bind activate different downstream transcriptional factors direct cell social behavior cell cell interactions review present latest findings role yap wwtr skin physiology pathology tumorigenesis discuss statuses newly developed therapeutic interventions target yap wwtr human cancers well prospects use skin cancer treatments elsevier rights reserved
many changes statistical theory past years including increased evidence non robust methods may fail detect important results statistical advice available software engineering researchers needs updated address issues paper aims explain new results area robust analysis methods provide large scale worked example new methods summarise results analyses type error efficiency power standard parametric non parametric statistical tests applied non normal data sets identify parametric non parametric methods robust non normality present analysis large scale software engineering experiment illustrate use illustrate use kernel density plots parametric non parametric methods using four different software engineering data sets explain methods necessary rationale selecting specific analysis suggest using kernel density plots rather box plots visualise data distributions parametric analysis recommend trimmed means support reliable tests differences central location two samples distribution data differs among groups ordinal scale data recommend non parametric methods cliff delta robust rank based anova like method
well known existence unstable sampled zero dynamics recognised major barrier many control problems usual digital control zero order hold zoh fractional order hold froh input used unstable sampled zero dynamics inevitably appear discrete time model even though continuous time system relative degree equal three minimum phase paper show approximate sampled data model obtained nonlinear systems use multirate input hold generalised sample hold function gshf order discrete zero dynamics resulting model arbitrarily placed furthermore properties sampled zero dynamics studied conditions ensuring stability sampling zero dynamics desired model derived results presented generalise well known notion sampling zero dynamics linear case nonlinear systems gshf provide advantages zoh froh terms stability discrete system zero dynamics
vulvovaginal candidiasis candidosis common fungal infection afflicting approximately women globally caused primarily yeast candida albicans fluconazole widely regarded antifungal drug choice since introduction due high oral bioavailability convenient dosing regimen favourable safety profile however widespread use led emergence fluconazole resistant albicans posing universal clinical concern coupled dearth new antifungal drugs entering market imperative introduce new drug classes counter threat antimicrobial peptides amps potential candidates due theirmembrane disruptingmechanism action specifically targeting fungal membranes rapidly fungicidal reduce chances resistance development treatment duration towards goal conducted head head comparison short linear amps literature identify peptide potent activity fluconazole resistant albicans residue peptide identified assayed panel clinical albicans isolates followed fungicidal static determination time kill assay gauge potential drug development copyright european peptide society john wiley sons ltd
humans typically exhibit tendency follow gaze conspecifics social attention behaviour known gaze cueing addressed whether episodically learned social knowledge behaviours performed individual bearing gaze influence phenomenon learning phase different faces systematically associated either positive negative behaviours faces used stimuli gaze cueing task results showed faces associated antisocial norm violating behaviours triggered stronger gaze cueing effects compared faces associated sociable behaviours importantly especially evident participants perceived presented normviolating behaviours far negative compared positive behaviours findings suggest reflexive attentional responses affected appraisal valence behaviours individuals around
politically aggressive militant groups usually rely support larger community although evidence suggests members larger community support aggression major subtype political aggression associated religious differences religio political aggression rpa little previous research explored demographic psychological factors might distinguish supporters non supporters rpa exploratory study investigated whether factors previously associated aggression might correlate support rpa case israeli palestinian conflict second intifada fifty two year old palestinian boys gaza completed self report measures life events emotional status political attitudes teenaged boys reported family members wounded killed israeli defense forces idf expressed greater support rpa addition boys felt group treated unjustly reported greater support rpa compared implications preliminary data discussed aggr behav wiley liss inc
designing materials targeted performance requirements required integrated computational materials engineering icme demands combined strategy bottom top modeling simulation treats various levels hierarchical material structure mathematical representation infusion systems engineering informatics deal differing model degrees freedom uncertainty moreover time classical materials selection approach becoming generalized address concurrent design microstructure mesostructure satisfy product level performance requirements computational materials science multiscale mechanics models play key roles evaluating performance metrics necessary support materials design interplay systems based design materials multiscale modeling methodologies core materials design high performance alloys composite materials maximum performance often achieved within relatively narrow window process path resulting microstructures much attention icme materials community focused role generating representing data including methods characterization digital representation microstructure well databases model integration hand computational mechanics materials multidisciplinary design optimization communities grappling many fundamental issues related stochasticity processes uncertainty data models multiscale modeling chains decision based design paper explores computational information aspects design materials hierarchical microstructures identifies key underdeveloped elements essential supporting icme one messages overview paper icme simply assemblage existing tools tools natural interfaces material structure framed way quantifies sources uncertainty manages uncertainty representing physical phenomena support decision based design elsevier ltd rights reserved
background aims low testosterone sarcopenia common men cirrhosis associated increased mortality whether testosterone therapy cirrhosis improves muscle mass outcomes unknown methods conducted month double blinded placebo controlled trial intramuscular testosterone undecanoate men established cirrhosis low serum testosterone total testosterone nmol free testosterone pmol single tertiary centre body composition assessed using dual energy ray absorptiometry baseline months results study completion appendicular lean mass significant higher testosterone treated subjects mean adjusted difference mad secondary outcomes included substantially higher total lean mass active group mad matched reduced fat mass mad total bone mass increased mad bone mineral density femoral neck mad points haemoglobin higher testosterone therapy mad percentage glycosylated haemoglobin hbalc lower mad mortality non significantly lower testosterone treated patients increase adverse events testosterone treated subjects conclusion testosterone therapy men cirrhosis low serum testosterone safely increases muscle mass bone mass haemoglobin reduces fat mass hbac first evidence based therapy sarcopenia cirrhosis thus requires larger scale investigation potential impact mortality lay summary low testosterone muscle wasting associated increased risk death men severe liver disease administering testosterone men liver disease low testosterone levels significantly increases muscle mass addition testosterone non muscle beneficial effects may able increase survival population european association study liver published elsevier rights reserved
digital control system dependency model actions operators differs conventional control room information sharing main control room mcr operations team operations dependencies actions operators common digital control system compared conventional control room operators share information mcr operations directed team decisions therefore assessing dependencies operators important aspect human reliability analysis study use fuzzy logic based approach evaluate dependencies among actions operators present study first factors influence dependency levels among actions operators identified analyzing characteristic human factors digital control system analytical model dependencies constructed second method analyzing dependencies actions operators established based fuzzy logic approach method simulate vague uncertain knowledge also provides clear explanation origins results reasoning process tracing steps reasoning therefore traceability repeatability characteristics proposed method third present case study demonstrate proposed approach finally demonstrate results obtained reasonable established model stable based validations involve data comparisons sensitivity analysis model elsevier rights reserved
modeling signal forms complex values common scientific problem present many applications medical signals computer graphics vision one possible solution utilization hankel singular value decomposition first step complex valued signal arranged special form called hankel matrix next step decomposed operation singular value decomposition obtained matrices reformulated order get parameters describing system basic method applied fitting whole signal fails modeling particular component signal modification basic hsvd method relies reiteration used main components application prior knowledge solves presented problem
increasing concern long term effects concussive sub concussive head accelerations sport research applies two technologies initially developed team based sports snowsports understand characteristics snowsport head acceleration results indicate pediatric snowsports participants regularly achieved speeds snowsport head accelerations rare occur generally low magnitude risk make snowboarders authors published elsevier ltd selection peer review responsibility school aerospace mechanical manufacturing engineering rmit university
complex network security resilience issue network important breakdown whole network triggered attack failure even single node paper cascading failure issue food supply chain addressed food supply chain network nodes interconnected interdependent tight coupling nodes increases efficiency food supply chain however association relation nodes may cause cascading failure food network firstly node importance evaluation method niem employed analyze cascading failure characteristics food supply chain network critical nodes may cause cascading failure whole network identified subsequently node importance evaluation method proposed protect critical notes finally cascading failure caused largest connected component tested using largest workload tolerance parameter
magnetic liquid known ferrofluid liquid acts smart material becomes strongly magnetized presence magnetic field aim work develop standard economical method synthesis iron oxide nanoparticles along coating oleic acid resulting good quality stable ferrofluid authors prepared ferrofluid nanoparticles suspended kerosene avoid aggregation nanoparticles coated oleic acid present work stability ferrofluid considered terms particle size size distribution magnetization properties final fluid studied help various analytical techniques ray diffraction xrd transmission electron microscopy tem fourier transform infrared spectroscopy ftir used determination characteristics ferrofluid like interatomic distance size shape particles adhesion oleic acid nanoparticles account synthesized ferrofluid remaining part work dedicated application ferrofluid inclination sensor present many commercial applications ferrofluids cancer detection mri test speakers etc focus given construct ferrofluid based inductive inclination sensor one application ferrofluid range inclination sensor developed degrees resolution approximate degrees
paper investigates concept electrically supercharged internal combustion engine ice powertrain supercharger consists electric motor compressor draws power electric energy buffer battery helps engine short duration high power demands engine buffer sized reduce sum vehicle operational fuel component engine buffer costs purpose convex driving cycle based vehicle model derived enabling formulation underlying optimization problemas second order cone program socp program efficiently solved using dedicated numerical tools given gear selection strategy provides optimal engine buffer sizes optimal vehicle control state trajectories compressor power buffer energy well finally results obtained representative numerical case study discussed detail
oral food challenges crucial role complex process diagnosing food allergy especially case unclear medical history food challenges help validate clinical relevance sensitization food allergens evaluate diagnosis particular infants young children precise diagnosis suspected food allergy major importance order avoid unneeded restrictive elimination diets prescribe appropriate dietary supplementation double blind placebo controlled food challenges dbpcfc considered gold standard procedure article provides hands procedures conduction oral food challenges pediatric population focus common ige mediated food allergies patient group
majority population dependent conventional energy sources day today needs leading edge research renewable sources energy rise order meet increasing energy demand without straining environment objective project harvest potential energy inherent tall buildings high altitudes using micro pelton turbine ground grey water rain water purified grey water collected tank placed centre building rain water collection tank placed top building control system designed optimum power output turbine monitor levels water separation storage used rainwater tank also controlled pelton turbine designed analyzed ansys fluent computationally power output number high rises escalating awareness rainwater harvesting renewable sources energy indispensable source energy turn viable option
paper present novel design features technical implementation evaluation radio frequency exposure systems developed national toxicology program ntp national institute environmental health sciences studies potential toxicity carcinogenicity second third generation mobile phone signals system requirements second year ntp cancer bioassay study tightly controlled lifetime exposure rodents rats mice three power levels plus sham simulating typical daily higher exposures users gsm cdma signals reverberation chambers animal housing designed allow extended exposure time per day free roaming individually housed animals performance chamber characterized terms homogeneity stirred unstirred energy efficiency achieved homogeneity mhz respectively temporal variation electric field strength optimized give similar characteristics power control phone real network using two stirrers experimental dosimetry performed validate sar sensitivity determine sar uniformity throughout exposure volume sar uniformities respectively rats mice achieved
introduction recent study indicates serotonin transporter function varies duration monthly sunshine finding may suggest efficacy serotonin selective reuptake inhibitors ssrs associated duration monthly sunshine information possible association lacking methods ninety one japanese subjects depression completed week treatment paroxetine clinical evaluation performed using montgomery asberg depression rating scale madrs treatment weeks treatment data duration monthly sunshine obtained meteorological agency website divided patients four groups nonresponders nrs later responders lrs early responders ers ultra early responders uers results responses paroxetine treatment group began treatment fall winter group began treatment spring summer differ significantly effect duration monthly sunshine paroxetine response time differ significantly among four groups whereas change duration monthly sunshine significant effect paroxetine response time limitations sample patients mdd small included hirosaki area conclusion change duration monthly sunshine associated paroxetine response time elsevier rights reserved
federal republic germany cope situation referred time verkehrskrise traffic crisis relatively short time span number cars german roads increased rapidly well number accidents fatalities correspondingly efforts traffic education heavily intensified examining public campaigns expert discourse article explores notion self control gained acceptance among road safety experts eventually helped establish paradigm change western german traffic education course three decades focus shifted enforcement appealing reason disciplinary endeavors internalization adequate behavior road competence behind wheel traffic education aimed motivate road users regulate improve ability adapt traffic situations tried establish specialized seventh sense core element vernacular risk practices road notion self control implemented public campaigns road safety activities relied societal models certain notions social political order included particular traditional family gender roles christian religious values democratic freedom therefore road traffic regarded cultural concept road safety discursive arena sense road safety appear static state state flux traffic thus required self control routinized yet flexible practices improve resilience individual road user risk accidents well resilience traffic system
purpose primary aim study determine whether severity incontinence associated dermatitis iad among nursing home based incontinence pad users varies pad designs second aim examine utility simple method reporting skin health problems healthcare assistants asked record basic observational data pad change study design randomized multiple crossover observational exploratory subjects setting twenty one men women using absorbent continence products contain urinary fecal incontinence recruited nursing homes london south england methods day time variant night time variant main disposable pad designs market moderate heavy incontinence tested insert pads stretch pants piece one diapers pull pants belted shape diapers pad variants day time use absorption capacity measured using iso international standards organization capacity night time variants resident used pad designs day time night time variants weeks order testing randomized nursing home skin health data collected using methods parallel method comprised visual observation researchers observation per pad design observations total weeks method healthcare assistants logged observational data skin health every pad change weeks primary outcome variable severity severe skin problem noted researcher resident pad design method descriptive data skin care methods used nursing homes also collected using short questionnaires researcher observation results significant differences severity incidence skin problems found observations using pad designs however wide range skin conditions recorded made classification difficult skin often marked creases absorbent products temporary marks pink purple discoloration observed cases severe erythema rashes vesicles commonly used descriptors previous skin tools nevertheless collected data reflect abundance skin problems difficult categorize neatly researcher observations method showed nearly residents least iad skin problem recorded week period residents least problem rated maximum severity healthcare assistants logged skin problems pad changes discrepancy researcher healthcare assistant data appears largely due healthcare assistants sometimes discounting low grade iad normal population conclusion incontinence associated dermatitis common among nursing home residents use incontinence pads often severe evidence found design pad likely others associated skin problems method devised enable healthcare assistants record basic observational data skin health diaper area pad change method proved simple use still resulted substantial underreporting iad suggesting work needed develop tool successfully encourages log treat iad problems
communication parents children represents important factor family socialization nevertheless little known parents communicate different ways qualitative differences parent child communication may affect child building self determination theory present study focuses motivational antecedents need supportive communication function parental child related beliefs long term goals parents set children future parental child related behavior expectations terms parental dissatisfaction satisfaction child behavior moreover effect perceived need supportive communication children prosocial behavior externalizing internalizing behavioral difficulties addressed three waves data mothers adolescents aged years analyzed using growth curve modeling found linearly increasing trajectories extrinsic parental goals children dissatisfaction child behavior decreasing trajectories need supportive communication individual differences vary significantly time addition holding extrinsic parental goals children positively predicts parents dissatisfaction child behavior negatively predicts need supportive communication parents dissatisfaction child behavior also contributes decreasing need supportive communication expected need supportive communication predicts prosocial behavior externalizing behavioral difficulties need supportive communication decreases time externalizing internalizing behavioral difficulties increase furthermore effect mothers beliefs adolescents socioemotional development mediated perceived mother communication quality results suggest parental child related beliefs important motivational antecedents parent child communication may prevent behavioral difficulties
brief conceives learning system implementing self optimization based dynamic server resource provisioning dsrp data centers deregulated electricity markets formulate dsrp problem constrained markov decision process minimize electricity cost subject constraint queue delay instead applying conventional learning solve problem postdecision state learning based dsrp algorithm fast convergence proposed estimating exploiting workload arrival distribution discuss offline optimization dsrp problem used performance benchmark proposed method finally evaluate performance proposed scheme using real workloads electricity prices
spark ignition engines nonlinear dynamic system inherent uncertainties unpredictable disturbances identification nonlinear system vital many fields engineering study engine torque identified input output measurement study aims propose dynamic nonlinear model uses adaptive neuro fuzzy inference system nonlinear auto regressive exogenous input structure identify dynamic nonlinear behavior engine considerable good performance achieved using adaptive neuro fuzzy inference system nonlinear auto regressive exogenous input method model validation proposed method compared conventional identification approach called hammerstein method results show two methods excellent agreement hammerstein model chosen identification result system studied previously author validation results prove ability proposed model capture highly nonlinear behavior system
association salivary flow rate sfr depressive symptoms inconclusive present study aimed investigate association sfr depressive symptoms without adjustment genetic family environmental factors conducted cross sectional study using twins measured sfr depressive symptoms outcome explanatory variables respectively also performed three step regression analyses first analysing association sfr depressive symptoms without adjustment genetic family environmental factors individual level analyses performed within analyses using monozygotic sex dizygotic twin pairs finally using twin pairs within analyses estimated coefficients adjusted genetic family environmental factors furthermore differences associations individual level within suggest confounding genetic family environmental factors conducted twins aged years individual level analyses males within analyses using sex male twin pairs sfr associated depressive symptoms within analyses using male twin pairs sfr associate depressive symptoms females sfr associate depressive symptoms individual level within analyses present study revealed association sfr depressive symptoms affected common genetic factors males understanding association sfr depressive symptoms adjustment genetic family environmental factors could lead important consideration prevention treatment hyposalivation
investigating raindrop size distributions dsds different cloud types essential rain characterization understanding different microphysical processes within cloud system study simultaneous measurements micro rain radar mrr joss waldvogel disdrometer jwd used investigate dsds different precipitation categories indian summer monsoon ism season june september period instruments deployed mahabaleshwar degrees degrees similar amsl located complex mountain terrain western ghats wgs india mrr reflectivity factor fall velocity profiles observed precipitation systems classified four categories shallow convective convective stratiform mixed convective stratiform terms rain occurrence frequency found rain mahabaleshwar mostly contributed shallow convective similar system stratiform system contribution convective mixed convective stratiform systems contributes different precipitation categories rain microphysical parameters median volume diameter rain liquid water content normalized intercept parameter estimated using moment method second third fourth moment observed dsds reflectivity rainfall relation form estimated precipitation categories studies systematic comprehensive classification precipitation types terms rain microphysical parameters relationships region important would improve understanding rain microphysics rainfall estimation active passive remote sensing devices elsevier rights reserved
aim aim study evaluate extracorporeal life support system ecls employed neonates pediatric cardiac intensive care unit material methods twenty five neonates required ecls november november evaluated results median age days range days median body weight range venoarterial ecls performed cases ascendan aorta right atrial cannulation patients neck cannulation three patients performed reason ecls cpr two patients inability wean cardiopulmonary bypass cpb seven patients respiratory insufficiency hypoxia nine patients low cardiac output lcos seven patients median duration ecls four days range hemorrhagic complications developed renal complications pulmonary complications infectious complications neurologic complications three mechanical complications two patients weaning successful patients eleven patients successfully discharged conclusion ecls important treatment option performed successfully many centers around world maintain life support patients unresponsive medical treatment utilization modality especially newborns congenital heart disease taken consideration
fertilizers undoubtedly contributed significant increase yields worldwide therefore considerable improvement quality life man animals today attention focussed risks imposed agricultural fertilizers effects include dissolution transport excess quantities fertilizer major trace elements groundwater deteriorate quality drinking irrigation water study map fertilizer water pollution index fwpi generated assessing impact agricultural fertilizers drinking irrigation water quality proposed methodology applied one intensively cultivated tree crops area crete greece potential pollutant loads derived exclusively agricultural activities groundwater main water source region groundwater sampling data wells collected year time period analyzed presence anionic cationic fertilizer trace elements chemicals components primary fertilizers used local tree crop production eight factors maps considered order estimate spatial distribution groundwater contamination fertilizer element eight factors combined used generate fertilizer water pollution index fwpi map indicating areas drinking irrigation water pollution due high groundwater contamination caused excessive fertilizer use moreover taking consideration groundwater flow direction seepage velocity pathway groundwater supply become polluted predicted groundwater quality results show small part study area polluted moderately polluted excessive use fertilizers considering area drinking water sources wells located study highlights analytic method delineation wellhead protection zones approaches incorporated useful gis decision support system aids decision makers difficult task protection groundwater resources elsevier ltd rights reserved
people accurately assess various personality traits others based body odor alone previous studies shown correlations odor ratings self assessed personality dimensions evident assessments neuroticism dominance tested differences assessments based natural body odor alone without use cosmetics assessments based body odor people allowed use cosmetics following daily routine sixty seven observers assessed samples odors odor donors odor donor provided two samples one one without cosmetic use donors provided personality ratings raters judged personality characteristics donors based provided odor samples correlations observers ratings self rated neuroticism stronger raters assessed body odor natural body odor condition natural condition cosmetics use condition cosmetics condition ratings dominance significantly predicted self assessed dominance conditions natural cosmetics whereas ratings extraversion predict self assessed extraversion either condition addition ratings body odor attractiveness pleasantness significantly lower natural condition cosmetics condition although intensity donors body odors similar conditions findings suggest although olfaction seems contribute accurate first impression judgments certain personality traits cosmetic use affect assessments others based body odor
purpose manifestation allergic disease depends genetic predisposition diet commensal microbiota genetic polymorphism mothers determines breast milk glycan composition one major determinant fucosyltransferase fut secretor gene shown linked commensal microbiota establishment studied whether fut dependent breast milk oligosaccharides associated allergic disease breast fed infants later life methods analyzed fut dependent oligosaccharides breast milk samples mothers placebo group randomized placebo controlled trial prebiotics probiotics preventive allergic disease infants high allergy risk trial registry number nct using logistic regression models studied associations fut dependent breast milk oligosaccharides incidence allergic disease years age results years years age observed presumed lower incidence ige associated eczema manifestation section born infants fed breast milk containing fut dependent oligosaccharides logistic regression observed similar relation presence fut dependent breast milk oligosaccharides ige associated disease ige associated eczema section born infants testing levels breast milk oligosaccharide fucosyllactose proxy fut activity observed significant associations section born infants allergic disease ige associated disease eczema ige associated eczema conclusion data indicate infants born section high hereditary risk allergies might lower risk manifest ige associated eczema years years age fed breast milk fut dependent milk oligosaccharides studies larger cohorts especially randomized controlled intervention trials required build preliminary observations
background candida leading cause infection infants extracorporeal membrane oxygenation ecmo optimal micafungin dosing unknown population ecmo alter drug pharmacokinetics methods characterize micafungin pharmacokinetics safety infants ecmo conducted open label pharmacokinetics trial infants ecmo either received intravenous micafungin every invasive candidiasis prophylaxis every fungal infection suspected confirmed collected plasma samples single multiple micafungin doses defined therapeutic target adult exposure associated efficacy phase iii trials prophylactic target one half therapeutic target results enrolled infants samples median age days using compartment model median weight normalized volume distribution clearance respectively dose exposure simulations revealed doses every matched exposure targets prophylaxis treatment invasive candidiasis respectively observe drug related adverse events conclusions infants ecmo micafungin volume distribution higher clearance upper range previously published values infants ecmo based data recommend dosing every prophylaxis treatment invasive candidiasis respectively match adult exposure proven effective candida spp
purpose integrating molecularly targeted compounds radiotherapy synergistic effects systemic agent radiation may extend limits patient tolerance increasing demand understanding pathophysiological mechanisms treatment toxicity pelvic radiation vorinostat pravo study investigated mechanisms adverse effects response histone deacetylase hdac inhibitor vorinostat suberoylanilide hydroxamic acid saha administered potential radiosensitiser materials methods phase study advanced gastrointestinal carcinoma conducted sequential patient cohorts exposed escalating doses vorinostat combined standard fractionated palliative radiotherapy pelvic target volumes gene expression microarray analysis study patient peripheral blood mononuclear cells pbmc followed functional validation cultured cell lines mice treated saha results pbmc transcriptional responses vorinostat including induction apoptosis confined tothe patient cohort reporting dose limiting intestinal toxicities relevant saha concentrations apoptotic features annexin staining caspase activation poly adp ribose polymerase cleavage observed cultured intestinal epithelial cells moreover saha treated mice displayed significant weight loss conclusion pravo study design implemented strategy explore treatment toxicity caused hdac inhibitor combined radiotherapy enabled identification apoptosis potential mechanism responsible dose limiting effects vorinostat best knowledge first report deciphering mechanisms normal tissue adverse effects response hdac inhibitor within combined modality treatment regimen
purpose aim study determine stability computer aided design manufacturing cad cam prefabricated abutment measuring removal torque cyclic loading materials methods three types fixture types abutments used removable torque measured cyclic loading cycles group procedure performed twice results first removal torque values newton centimeter measured stock versus custom abutments follows group versus group versus group versus second removal torque values newton centimeter also measured group versus group versus group versus significant difference stock custom abutments either first second removal torque values also significant difference among initial tightening torque first second removal torque conclusion precise control cad cam abutments good screw joint stability achieved
mechanical unloading leads bone loss disuse osteoporosis partly due impaired osteoblastogenesis bone marrow stromal cells bmscs however underlying molecular mechanisms phenomenon fully understood study demonstrated cyclic mechanical stretch cms promotes osteoblastogenesis bmscs vivo vitro besides found hedgehog signaling pathway activated process inhibition either knockdown sonic hedgehog shh treating bmscs inhibitors attenuated osteogenic effect cms bmscs suggesting signaling pathway acts endogenous mediator mechanical stimuli bmscs furthermore demonstrated shh expression level regulated dna methylation mechanism chromatin immunoprecipitation chip assay showed dna methyltransferase dnmtb binds shh gene promoter leading dna hypermethylation mechanical unloading bmscs however mechanical stimulation regulates protein level dnmtb results dna demethylation shh expression importantly found inhibition dnmtb partly rescued bone loss mice mechanical unloading results demonstrate first time mechanical stimulation regulates osteoblastic genes expression via direct regulation dnmtb therapeutic inhibition dnmtb may efficient strategy enhancing bone formation mechanical unloading
paper seeks analyze influence weather person self reported life satisfaction theoretical level claimed nice weather improve affective well person given argued affects turn impact person general assessment life particular expected people would report higher life satisfaction days unambiguously nice weather data three german large scale surveys used test empirically extent self reported life satisfaction determined weather results mostly consistent initial hypothesis three samples respondents surveyed days exceptionally sunny weather reported higher life satisfaction compared respondents interviewed days ordinary weather two three samples difference statistically significant hence supposed sunshine effect peoples life satisfaction indeed exist implications findings discussed conclusion
objective compare health service utilization disability claims among military personnel multisymptom illness msi chronic diseases chronic disease without msi chronic diseases msi also known gulf war illness design cohort study setting australia participants total participants gulf war veterans study conducted wave followed wave aged average years msi chronic disease neither chronic disease msi methods wave cohort linked national medicare department veterans affairs dva databases obtain health service utilization disability claims data recorded results likelihood visiting general practitioner risk ratio confidence interval visiting specialist medical doctor hospitalizations months preceding wave successfully claiming dva disability compensation similar personnel msi chronic disease however consultations hospitalizations specialist doctor consultations disability claims significantly higher among msi without msi chronic diseases conclusions health service use disability claims personnel msi comparable chronic disease excess without msi chronic diseases hence recognition high health service use personnel msi important ensure adequate provision health services
background following recent approval pirfenidone nintedanib idiopathic pulmonary fibrosis ipf questions arise use antifibrotics patients awaiting lung transplantation ltx methods safety efficacy antifibrotic drugs ipf patients undergoing ltx investigated single centre retrospective cohort analysis results total nine patients receiving antifibrotic therapy days subsequent ltx included major side effects noted significant weight loss occurred antifibrotic treatment fvc tended stabilize weeks treatment patients moderate decline fvc tlc dlco noted whole pretransplant time period antifibrotic therapy functional exercise capacity lung allocation score remained unchanged post operative thoracic wound healing problems severe early anastomotic airway complications attributable prior antifibrotic treatment none patients developed chronic lung allograft dysfunction median follow months post transplant survival year years conclusions antifibrotic drugs probably safely administered ipf patients possibly attenuating disease progression time awaiting ltx
placement geotextile tubes plays functional role performance overall protection scheme placement path geotextile tubes crucial decision designers geotextile tubes widely used reef structure well mean sea level requirement beach width main criterion decide crest level nearshore reef structure case beach nourishment project segmented row tubes placed msl used dual purpose firstly acts offshore reef helps trapping sediments downrush secondly barrier offshore movement existing nourished sand recurring periodic expenditure beach nourishment would also decreases beach stabilization within years based onshore offshore movement alongshore littoral drift solutions form parallel offshore reef perpendicular groyne field sand filled geotextile tubes decided importance site specific design geotextile tubes accordance needs site conditions etc discussed details case studies authors published elsevier
new application omega fatty acids recently emerged concerning treatment several mental disorders indication supported data neurobiological research highly unsaturated fatty acids hufas highly concentrated neural phospholipids important components neuronal cell membrane modulate mechanisms brain cell signaling including dopaminergic serotonergic pathways aim review provide complete updated account empirical evidence efficacy safety currently available omega fatty acids treatment psychiatric disorders main evidence effectiveness eicosapentaenoic acid epa docosahexaenoic acid dha obtained mood disorders particular treatment depressive symptoms unipolar bipolar depression evidence support use omega fatty acids treatment conditions characterized high level impulsivity aggression borderline personality disorders patients attention deficit hyperactivity disorder small modest effects omega hufas found promising results reported studies using high doses epa association omega omega fatty acids schizophrenia current data conclusive allow either refuse support indication omega fatty acids remaining psychiatric disturbances including autism spectrum disorders anxiety disorders obsessive compulsive disorder eating disorders substance use disorder data scarce draw conclusion concerning tolerability several studies concluded omega considered safe well tolerated doses day
objectives youth participation competitive athletics significantly increased past two decades also recent rise number sports injuries physicians seeing young athletes objective study assess likelihood sports injuries based several risk factors general sample athletes suburban area high school methods cross sectional study online survey distributed student athletes local high school mean age years four hundred eighty four complete responses received data collected survey included demographics frequency sports participation level participation types sports played participation cross training injuries incurred use non steroidal anti inflammatory drugs treatment sports injuries results athletes played average different sports average number hours participation sports annually hours average total number sports injuries experienced athletes study per participant respondents reported sustained least one sports injury higher total number hours per year sports participation playing contact sport significantly associated reported lifetime sports injuries older age playing contact sport playing travel club team associated students using nsaids sports injuries older age playing contact sport cross training also associated surgery sports injury conclusions although hours participation playing contact sport may lead increased number injuries risk must weighed myriad benefits sports provide young athletes
spinal cord white gray matter affected various pathologies multiple sclerosis amyotrophic lateral sclerosis trauma able precisely segment white gray matter could help image analysis hence useful understanding pathologies helping diagnosis prognosis drug development date white gray matter segmentation mostly done manually time consuming induces bias related rater prevents large scale multi center studies recently methods proposed automatically segment spinal cord white gray matter however single method exists combines following criteria fully automatic works various contrasts iii robust towards pathology freely available open source study propose multi atlas based method segmentation spinal cord white gray matter addresses previous limitations moreover study spinal cord morphology atlas based approaches increasingly used approaches rely registration spinal cord template image however registration usually take account spinal cord internal structure thus lacks accuracy study propose new template registration framework integrates white gray matter segmentation account specific gray matter shape individual subject validation segmentation performed healthy subjects using weighted images healthy subjects using diffusion weighted images exhibiting inverted white gray matter contrast compared weighted patients spinal cord injury template registration validated subjects using weighted data results automatic segmentation weighted images close correspondence manual segmentation dice coefficient white gray matter respectively similarly good results obtained data inverted contrast diffusion weighted image patients compared classical template registration framework proposed framework accounts gray matter shape significantly improved quality registration comparing dice coefficient gray matter validation needed show benefits new registration framework large cohorts variety patients study provides fully integrated tool quantitative assessment white gray matter morphometry template based analysis proposed methods implemented spinal cord toolbox sct open source software processing spinal cord multi parametric mri data
goal present study examine contributions associative strength similarity terms shared features production false memories deese roediger mcdermott list learning paradigm whereas activation monitoring account suggests false memories driven automatic associative activation list items nonpresented lures combined errors source monitoring accounts fuzzy trace theory global matching models emphasize importance semantic level similarity thus predict shared features list lure items increase false memory participants studied lists nine items related nonpresented lure half lists consisted items associated share features lure half included items equally associated also shared features lure many cases taxonomically related items two types lists carefully matched terms variety lexical semantic factors lures used across list types two experiments false recognition critical lures greater following study lists shared features critical lure suggesting similarity categorical taxonomic level contributes false memory beyond associative strength refer phenomenon feature boost reflects additive effects shared meaning association strength generally consistent accounts false memory emphasized thematic feature level similarity among studied nonstudied representations
design education need wider restructuring accommodate new developments paradigmatic shifts brought forth information age capitalise move towards complexity theory systems science digital technologies intention article approach one particular aspect need basic design education reconsidered establish arguably broken link learning tradition bauhaus oriented basic design education computational parametric logic necessitated contemporary design technologies authors present overall outlines basic design course offered beykent university department industrial design istanbul turkey programme consists series exercises grouped five modules two binders structured link fundamental notions operations design thinking covered basic design courses first year analytical computational reasoning competencies developed mostly later years design education
pulmonary mucormycosis opportunistic fungal infection immunocompromised individuals difficult diagnose requires tissue biopsy generally patients unfit undergo invasive lung biopsies describe novel technique case uncontrolled diabetes mellitus nonresolving pulmonary cavitary disease convex probe endobronchial ultrasound ebus guided aspiration lung cavity wall showed classical histopathological picture establishing diagnosis mucorale infection ebus real time minimally invasive technique minimal risk complications led early diagnosis prompt treatment appears novel diagnostic modality pulmonary mucormycosis minimal complications compared biopsy methods high complication risk
brand new technology sintering titanium tested first time titanium powder pressure less sintered argon atmosphere different temperatures time vertical axis solar furnace plataforma solar almeria psa spain decrease final porosity increasing sintering temperature time constant heating rate observed obtained results compared obtained identical green powder compacts sintered vacuum furnace final porosity achieved shorter sintering times observed radial shrinkage samples solar furnace almost vacuum furnace contrary axial shrinkage higher proposed attributed argon gas used sintering due different heating solar furnace sintering argon lower temperature acts heat transfer medium helps distribute heat homogeneously powder compacts higher temperature remains enclosed pores thereby increasing bit final compact porosity compared vacuum furnace showed contents final compacts depend predominantly concentration original powder observed increase due technology ppm oxygen ppm nitrogen hydrogen concentration decreased significantly microhardness dependence porosity prepared samples also investigated microhardness bulk prepared solar furnace estimated elsevier rights reserved
four diets arranged using factorial design two levels lignocellulose high low level acid detergent fibre adf combined two levels starch replacing digestible fibre hemicelluloses pectins high starch low low starch high level starch two trials conducted measure digestive efficiency rate passage respectively third trial performed network six french experimental breeding units measure growth digestive health rabbits per diet foods offered libitum weaning slaughter significant interactions detected effect level lignocellulose effect starch replacement rabbit digestion performance digestive health proportional increase overall food digestibility organic matter energy observed decrease adf level replaced starch observed significant improvement energy digestibility units whole tract mean retention time particles significantly longer lower adf level diets tended increase substituted starch diets weaning slaughter food intake mainly affected adf level day respectively diets lesser extent replacement starch day respectively diets weight gain slightly higher high starch low diets day without effect adf level weaning slaughter morbidity mortality rates acute diarrhoea significantly reduced high fibre diets units respectively replacement starch significant effect
background stable type suspension bridge suspension bridge inverse tensional system effect inverse tensional system suspension bridge studied using finite element method three dimensional finite element model stable type suspension bridge common suspension bridge established fish bone model consisting beam elements respectively finite element characteristic equation two bridges solved block lanczos method respectively order eigenpairs two kind suspension bridges obtained inherent characteristics two type bridges analyzed comparatively results showed due effect inverse tensional structures overall stiffness stable suspension bridge better common suspension bridge obviously effectively suppress torsional vibration suspension bridge
introduction diabetes mellitus characterized chronic hyperglycemia states development specific microvascular disorders retinopathy nephropathy conventional methods used study vascular compromise entity however use capillaroscopy evaluation capillary microarchitecture frequently used methods materials observational descriptive study patients established diagnosis control group underwent initial capillaroscopy examination parameters considered capillary diameter ectasia giant capillaries cross linked tortuous arborified capillaries avascular zones haemorrhages dominant morphology visibility subpapillary venous plexus spvp cuticulitis pattern results capillaroscopy performed patients findings tortous capillaries crosslinked capillaries avascular areas ectasias giant capillaries capillaroscopic findings evident majority studied population compared capillaroscopic alterations conclusion significant capillaroscopic changes demonstrated patients turn described specific pattern consisting capillary dilatation avascular zones tortuous capillaries patients morbidities evolution disease showed greater microvascular damage elsevier inc rights reserved
response requirements applications work large amounts data various nosql databases appeared deal specifically challenges systems become popular environments data analytics oltp however data intensive applications benefit databases life sciences domain many applications still use flat files medium store data see limited terms scalability performance well code complexity present analysis viability using databases applications data demands differ characteristics systems originally designed using databases also observe design data model queries configuration parameters considerable impact performance thus present examples different data system configurations analyse effects performance executions presented paper see performance gaps factor almost using different models queries configuration parameters
aim assess impact association elevated oestradiol low testosterone levels erectile dysfunction severity total male patients normal low level association normal elevated levels enrolled patients underwent routine laboratory investigations addition measurements total total follicle stimulating hormone fsh luteinizing hormone prolactin compared responses erectile function domain achieving erection maintaining erection international index erectile function iief score patients following normal levels low level low level elevated level elevated level patients included normal levels low level low level elevated level elevated level increased severity significantly associated low levels elevated levels low level elevated level additionally mean values domain significantly lower patients low level elevated level compared patients condition alone conclusion low level primary effect erectile function however concomitantly elevated level additive impairment effect
study various coping strategies used forest based rural communities vhembe district south africa response climate variability change challenges investigated effect community socio demographic characteristics adaptive capacity choice effectiveness coping strategies examined household level data collected respondents selected rural communities using proportionate random sampling procedure pearson chi square test used analyse coping strategies effects household community socio demographic characteristics choice effectiveness coping strategies determined using binary logit model observed respondents used diverse coping strategies depending nature climate variability extreme weather events confronted rainwater harvesting popular strategy respondents makhado mutale thulamela used cope erratic rainfall tree planting around houses farmland popular strategies counter effects extreme temperature furthermore household community demographic characteristics particular education skills levels forest products institutional services infrastructure available communities markets water supply facilities significantly influenced choice households coping strategies therefore hypothesized efforts enhance household capacity community infrastructural development might viable sustainable ways improving rural communities resilience climate change variability challenges elsevier rights reserved
objectives purpose examine effectiveness music care cognitive function depression behavioral problems among elderly people dementia long term care facilities taiwan methods study quasi experimental longitudinal research design used two groups subjects subjects randomly assigned experimental group comparison group based bandura social cognition theory subjects experimental group received kagayashiki music care kmc twice per week weeks subjects comparison group provided activities usual results results found using control score clifton assessment procedures elderly behavior rating scale baseline time attending kmc activities covariate two groups subjects statistically significant differences mini mental state examination mmse results also showed using control score cornell scale depression dementia baseline mmse baseline covariate two groups subjects statistically significant differences clifton assessment procedures elderly behavior rating scale conclusion findings provide information staff caregivers long term care facilities develop non invasive care model elderly people dementia deal depression anxiety behavioral problems
discuss modeling dielectric responses electromagnetically excited networks composed mixture capacitors resistors networks employed lumped parameter circuits model response composite materials containing conductive insulating grains dynamics excited network systems studied using state space model derived randomized incidence matrix time frequency domain responses synthetic data sets generated state space models analyzed purpose estimating fraction capacitors network good results obtained using either time domain response pulse excitation impedance data selected frequencies chemometric framework based successive projections algorithm spa enables construction multiple linear regression mlr models efficiently determine ratio conductive insulating components composite material samples proposed method avoids restrictions commonly associated archie law application percolation theory kohlrausch williams watts models applicable experimental results generated either time domain transient spectrometers continuous wave instruments furthermore quite generic applicable tomography acoustics well spectroscopies nuclear magnetic resonance electron paramagnetic resonance therefore general interest across dielectrics community
brain metastasis non small cell lung cancer remains challenge physicians occurs patients advanced stage adenocarcinoma lung often regarded ominous sign disease progression death alectinib likely promising agent even failure crizotinib ceritinib patients anaplastic lymphoma kinase alk driven non small cell lung cancer brain metastasis resulting durable response intracranial extra cranial diseases
design two dimensional rotational core loss setup considers sensor sizing airflux leakage field presented length flux density coils evaluated based magnetic degradation caused holes used locate coils measured core loss shown independent planar magnetic field coil size depends location thickness enclosed core area determines extent airflux leakage field measured field field links air close sample surface shown bias shape magnitude phase measured magnetic field core losses measured using three testers show airflux leakage field reduces increasing magnetizer diametrical size however independent stack length compact magnetizers finally performance proposed magnetizer assessed khz
rotational speed measurement key issue industries either process control characterization fault diagnosis electric motor driven systems used example estimate motor load pulley belt transmission slip encoders resolvers typically used continuous speed monitoring requiring mechanical coupling rotating shaft part speed measured given instant moments noninvasive contactless optical tachometers used using optical reflection stroboscopic principles cases stroboscopic tachometers require reflective elements strips rotating part however user wants continuously measure speed given rotating part audit characterization period real time data logging without sticking reflective strips introducing shaft coupled encoders resolvers low cost commercial solution perform task example user aim continuously estimate load variation induction motor day week basis slip speed value possible conventional commercial low cost contactless equipment unless user uses expensive online operation equipment estimating speed means input voltage current moreover rotating systems parts directly driven electric motor online equipment used practical cases even impossible couple encoder resolver stick reflective strips paper innovative nonintrusive low cost webcam based tachometer proposed developed experimentally tested used easily estimate record speed time example electrical motors pulleys shafts wind turbines
objective determine difference physical activity levels one year unilateral primary total hip replacement data sources search performed july studies eligible inclusion presented preoperative one year postoperative measures physical activity patients undergone unilateral primary total hip replacement review methods article used measure physical activity pre one year post unilateral primary total hip replacement data synthesised using meta analysis confidence intervals appropriate critical appraisal skills programme cohort study checklist used assess quality evidence results citations studies selected nine studies analysed meta analysis eight studies analysed qualitatively quality evidence low moderate statistically significant difference physical activity pre post total hip replacement assessed using movement related activity mean difference percentage hours spent walking minute walk test cardiopulmonary exercise test conclusion statistically significant difference physical activity levels one year unilateral primary total hip replacement however low moderate methodological quality included articles taken consideration drawing conclusions
individuals trait alexithymia display poor cognitive assimilation thoughts feelings emotions may result persistence stress anxiety depressive disorders cumulative effect psychological distress also linked clinical markers human immunodeficiency virus hiv disease progression study examines indirect effect hiv viral load function baseline levels change psychological distress hiv positive adults aged years provided blood samples hiv viral rna lymphocytes along self reported stress anxiety depression every months years second order conditional latent growth model used represent baseline year change cumulative levels psychological distress test indirect effect baseline levels trait change hiv viral load latent measure associated baseline latent change psychological distress furthermore baseline psychological distress predicted year change hiv viral rna controlling viral load baseline altogether trait significant indirect effect change viral load beta function baseline levels distress identification communication thoughts feelings emotions important long term psychological adaptation hiv greater psychological distress turn allows persistence peripheral viral replication
fast growing populations development energy crisis raised critical requirements utilization clean solar energy effective methods capture convert solar energy include photocatalytic degradation hydrogen production dye sensitized solar cells photocatalytic selective reaction organic compounds key factors utilization solar energy many photocatalysts exploited great achievements made ceria ceo possesses unique electrons attracted much interest due special electronic optical structures outstanding physical chemical properties review aims provide overview present progress study photocatalytic performance ceo ceo based materials photo degradation solar hydrogen production photo selective reactions also discuss factors affect photocatalytic performance photocatalysts including morphologies structure constitution ceo ceo based nanomaterials moreover current challenges future opportunities ceo ceo based materials capture conversion solar energy also discussed
objective analyze characteristics providers performing stress urinary incontinence sui pelvic organ prolapse pop procedures united states methods centers medicare services public database released years queried sui related pop related healthcare common procedure coding system providers categorized female pelvic medicine reconstructive surgery fpmrs providers non fpmrs providers using list fpmrs board certified providers compiled american board medical subspecialties website physician specialties submitted sui pop procedures claims tabulated results six hundred twenty nine fpmrs non fpmrs providers submitted claims sui pop procedures sui procedures claims following provider specialty distribution obstetrics gynecology gyn fpmrs urology gyn urology fpmrs remaining performed specialties pop procedures following specialty distribution gyn fpmrs gyn urology urology fpmrs remaining performed specialties provider distribution compared transvaginal mesh sling insertion procedures transvaginal mesh sling removal procedures fpmrs providers claimed sling transvaginal mesh insertion procedures performed mesh sling removal procedures conclusions medicare reimbursement data provides unique insight distribution provider specialties performing sui related pop related procedures medicare population gyn fpmrs providers submitted majority claims sui pop procedures fpmrs providers also performing majority mesh removal procedures
purpose emergency department nurses suffer persistent stress experiencing traumatic event exposure middle east respiratory syndrome coronavirus mers cov subsequently lead burnout study aimed assess nurses burnout level outbreak mers cov identify influencing factors order provide basic information lowering preventing level burnout methods study participants nurses working eight hospitals designated treating merscov infected patients korea performed multiple regression analysis explore factors influencing burnout results nurses burnout affected job stress beta poor hospital resources treatment mers cov beta poor support family friends beta three variables explained variance burnout conclusions nurses taking care mers cov infected patients aware burnout higher nurses divisions nurses hospital departments job stress biggest influential factor burnout ready outbreak emerging contagious diseases mers cov efforts preparations made reduce burnout job stress managed resolved working conditions mitigating job stress systematic stress management programs provided hospital resources treatment mers cov need reinforced moreover promoting support family friends required copyright korean society nursing science published elsevier open access article license http creativecommons orgilicensesiby
paper describes computational model based lumped elements mutual coupling phases transmission lines without explicit use modal transformation matrices self mutual parameters coupling phases modeled using modal transformation techniques modal representation developed intrinsic consideration modal transformation matrix resulting system time domain differential equations described state equations thus detailed profile currents voltages line easily calculated using numerical analytical integration methods however original contribution article proposal time domain model without successive phase mode transformations practical implementation based conventional electrical circuits without use electromagnetic theory model coupling phases
report analyzes health benefits associated driving electric vehicle compares cost expanding electric vehicle charging infrastructure damages related poor air quality sick days increased chronic illness quantified reductions instances issues resulted benefit reaped governments municipalities results indicate benefits associated improved air quality general exceed costs installing additional charging stations findings indicate overall outlook future expansion charging stations borne improved air quality provided increasing movement away traditional internal combustion engine vehicles towards electrified mobility options
bottom multiscale modeling approach presented carry high fidelity virtual mechanical tests composite materials structures strategy begins situ measurement matrix interface mechanical properties nanometer micrometer range build ladder numerical simulations take account relevant deformation failure mechanisms different length scales relevant individual plies laminates components main features simulation step information transferred length scales described detail well current limitations areas development finally roadmap extension current strategy include functional properties processing simulation scheme delineated
construction process reengineering cpr used reengineer construction process engineering project using thought method business process reengineering bpr improve efficiency engineering construction cpr theory provides improvement direction construction project information management data oriented function oriented bases realize support engineering construction project management information system management process realize objective information integration knowledge sharing premise process optimization paper makes research process method construction project management process reengineering based cpr theory puts forward design thought engineering construction project management information system based cpr theory uses jee technology set information platform realize support construction management process
city numerous items many unnoticed essential case signals signals considered objects reduced technological interest paper prove making smart integrating iot internet things could relevant contribution smart city paper presents concept smart signal device conscious context communication skills able offer best message user ubiquitous element contributes information city present design considerations real implementation validation system one challenging environments may exist city tunnel main advantages smart signal improvement actual functionality signal providing new interaction capabilities users new sensory mechanism smart city
big brown bats eptesicus fuscus overwintering outside underground environment believed play role epidemiology disease white nose syndrome wns caused fungus pseudogymnoascus destructans using quantitative real time pcr qpcr provide molecular evidence four big brown bats overwintering heated buildings new brunswick canada two affected individuals also mild focal pustular fungal dermatitis identified microscopically third bat qpcr negative similar fungal lesions despite determining fungal lesions caused suspected ascomycete intralesional fungi confirmed findings demonstrate bats overwintering heated buildings ground sites may subclinical preclinical wns contaminated could play role local dispersal inability determine ascomycetes causing pustular lesions highlights need ancillary diagnostic tests situ hybridization immunohistochemistry detected directly within lesion host pathogen relationship evolves bat species exposed fungus varying temperature regimes lesions may become less stereotypic tests could help define changes
optical cloaking one unattainable dreams subject fiction recently several different approaches cloaking proposed demonstrated stealth technology active camouflage transformation optics last one would formal approach modifying electromagnetic field around object cloaked metamaterials cloaking based transformation optics though valid single frequency experimentally demonstrated microwave region operation visible spectrum still distant realisation mainly owing difficulty fabricating metamaterial structure whose elements much smaller wavelength light show achromatic optical cloaking visible spectrum possible mere principle based geometrical optics combining pair polarising beam splitters right angled prisms rays light obstructed object make detour observer unobstructed rays straight two polarising beam splitters observed eventually device simply background image nothing exists
integrating next generation sequencing ngs bioinformatics electron microscopy conventional molecular biology tools new virus infecting kiwifruit vines identified characterized associated double membrane bound bodies infected tissues genome composed rna segments one containing single open reading frame negative polarity virus shows typical features members genus emaravirus five genomic rna segments identified additional molecular signatures viral rnas proteins encode together data phylogenetic analyses support proposal creating new species genus emaravirus classify novel virus tentatively named actinidia chlorotic ringspot associated virus accrav bioassays showed accrav mechanically transmissible nicotiana benthamiana plants turn may develop chlorotic spots ringspots field surveys disclosed presence accrav four different species kiwifruit vines five different provinces central western china support association novel virus symptoms leaf chlorotic ringspots actinidia data molecular features small rnas nucleotides derived accrav rnas targeted host rna silencing mechanisms also reported possible molecular pathways involved biogenesis discussed
rna binding proteins rbps implicated cancer development integrated bioinformatics analysis rbps various datasets revealed several genetic epigenetically altered events among rbps glioblastoma gbm identified mutated differentially regulated rbps gbm samples mutations ahnak predicted poor prognosis copy number variation cnv dna methylation mirna targeting contributed rbp differential regulation two sets differentially regulated rbps may implicated initial astrocytic transformation glioma progression identified also identified four rbp nol suclg herc aff signature unique expression pattern glioma stem like cells gscs independent poor prognostic indicator gbm rbp risk score derived signature also stratified gbm low risk high risk groups significant survival difference silencing nol suclg herc inhibited gsc maintenance gene set enrichment analysis differentially regulated genes high risk low risk underscored importance inflammation emt hypoxia high risk gbm thus provide comprehensive overview genetic epigenetic regulation rbps glioma development progression
review summarises aspects vitamin metabolism consequences vitamin deficiency impact vitamin supplementation musculoskeletal health older age age changes vitamin exposure cutaneous vitamin synthesis behavioural factors including physical activity diet sun exposure compounded changes calcium vitamin pathophysiology altered calcium absorption decreased vitamin hydroxylation lower renal fractional calcium reabsorption rise parathyroid hormone hypovitaminosis common associated risk osteomalacia particularly older adults rates vitamin deficiency range depending threshold circulating used population studied season relationship vitamin status osteoporosis less clear circulating linear relationship bone mineral density bmd epidemiological studies consistent across racial groups results randomized controlled trials vitamin supplementation bmd also inconsistent studies may less relevant older population example half participants robust meta analysis aged years impact bmd treating vitamin deficiency osteomalacia also rarely considered intervention studies considering osteoporosis fracture risk main concern vitamin therapy consistent fracture prevention effect except studies calcium coprescribed particularly frail populations living care homes shaped effect falls fracture risk becoming evident vitamin interventions target greatest risk may benefit vitamin supplementation decrease falls fractures although optimum dose still unclear
present article aims give overview current surgical techniques arthroscopic rotator cuff repair depending affected tendons size tear several methods refixation available articular sided partial tears supraspinatus tendon transtendinous repair tendon performed good clinical outcomes complete tears superior posterosuperior cuff single double row techniques available despite promising biomechanical properties double row techniques respective clinical results superior single row technique modified suture configuration whereas tears subscapularis tendon long thought repairable open surgery results arthroscopic refixation especially cranial part tendon promising biological augmentation rotator cuff repairs platelet rich plasma able increase healing rate far
saccadic adaptation used study disturbances sensory processing motor learning investigated whether patients schizophrenia adjust saccadic amplitudes account increase visual error saccade flight whether transfer change visuo manual localization task fourteen patients mean years healthy controls mean years performed adaptation trials degrees target shifts degrees outward direction determined percent amplitude change adaptation adaptation speed addition subjects localized stimulus flashed saccade target onset measure transfer change visual space perception visuo manual coordination eye movements recorded saccade amplitudes increased adaptation trials similarly groups amplitude variability adaptation higher patients degrees degrees controls degrees degrees adaptation speed slower patients controls pre post adaptation saccade metrics differ groups adaptation process shifted localization flashed target adaptation direction similarly groups use error signals internal recalibration sensorimotor systems transfer recalibration visual space perception appear basically unimpaired schizophrenia higher amplitude variability patients suggests certain instability saccadic control cerebellar systems patients seem rely visual error processing frontal circuitry resulting slower adaptation speeds despite unimpaired adaptation strength
objective build mouse osteoblast mct mouse osteoclast raw culture system study effect icariin activity osteoblasts osteoclasts culture system methods vitro acquisition cultivation mouse osteoblasts mct mouse raw cells conducted osteoblast osteoclast activities cells detected cck staining experiment alizarin red staining tartaric resistant acid phosphatase trap staining used different concentrations icariin interfere osteoblast osteoclast culture system effects icariin various genes detected pcr western blot methods correction expression ppar gamma bmd analyzed patients osteoporosis results mouse osteoblast osteoclast culture system built osteogenic differentiation effect enhanced icariin improve mct osteogenic differentiation activity enhance expression opg rankl gene protein reduce gene protein expression increase alp tgf rankl gene expression level reduce rank gene expression icariin act mct cells raw cells culture system promote osteogenic activity mct cells inhibit osteoclast activity raw cells reduce level bmscs adipogenic differentiation expression level ppar gene negatively correlated level bmd conclusions mouse mct cells mouse raw cells could cultured vitro icariin could improve osteogenic activity mct cells raw cells decrease osteoclast activity icariin could inhibit adipogenic differentiation bmscs osteoblast osteoclast culture promoting osteogenic differentiation inhibiting osteoclast differentiation elsevier masson sas rights reserved
paper analyses vehicle dynamics operation drive wheel load parameters vehicle model calculated vehicle force equations validate model speed torque measurements conventional car fiat punto carried well comparison measured simulated values electric motor inverter batteries dimensioned basis vehicle traction characteristics models internal combustion engine ice gear box electrical drive motor inverter batteries made comparison hybrid conventional drives fuel consumption made
high spatial resolution images well image processing object detection algorithms recent technologies aid study biodiversity commercial plantations forest species paper seeks contribute knowledge regarding use technologies studying randomly dispersed native palm tree analyze automatic detection large circular crown lcc palm tree using high spatial resolution panchromatic geoeye image taken area community small agricultural farms brazilian amazon also propose auxiliary methods estimate density lcc palm tree attalea speciosa babassu based detection results used compt palm algorithm based detection palm tree shadows open areas via mathematical morphology techniques spatial information validated using field methods structural census georeferencing algorithm recognized individuals life stages extraction percentage branching factor quality percentage factors used evaluate performance principal components analysis showed structure studied species differs species approximately babassu individuals stage detected individuals significantly smaller stipes undetected ones turn stage babassu individuals detected showing significantly different total height different number leaves undetected ones calculations regarding resource availability indicate contained adult babassu palm tree annual potential productivity almond oil detection lcc palm tree implementation auxiliary field methods estimate babassu density important first step monitor industry resource extremely important brazilian economy thousands families large scale elsevier ltd rights reserved
gene regulation modulates rna expression via transcription factors posttranscriptional gene regulation turn influences amount protein product example micrornas mirnas experimental establishment mirnas effects complicated even futile aiming establish entirety mirna target interactions therefore computational approaches proposed many tools rely machine learning involves example selection feature extraction model training algorithm selection parameter optimization different algorithms used model training various example sets features describing pre mirnas proposed different training testing schemes used model establishment pre mirna detection negative examples easily established causing problem two class classification algorithms also consensus approach works best therefore set forth established impact different parts involved model performance furthermore established two new negative datasets analyzed impact using training testing aim attach order importance parts involved pre mirna detection instead found parts intricately connected contributions easily untangled leading suggest attempting based pre mirna detection many scenarios need explored
per major allergen american cockroach recognized important cause imunoglobulin mediated type hypersensitivity worldwide however neasy obtain substantial quantity allergen use functional studies present study per gene cloned expressed escherichia coli coli systems found sera patients allergies caused american reacted per assessed enzyme linked immunosorbent assay confirming per major allergen induction expression ccr passively sensitized basophils sera patients allergies caused american approximately fold indicated recombinant per functionally active three immunoinformatics tools including dnastar protean system bioinformatics predicted antigenic peptides bpap system bepipred server used predict potential cell epitopes net mhciipan netmhcii used predict cell epitopes per result predicted peptides potential cell linear epitopes cell prediction per allergen predicted potential cell epitope sequences findings study may prove useful development peptide based vaccines combat induced allergies
background migraine one common disabling medical conditions affecting general population causing huge socioeconomic costs globally current available treatment options inadequate serotonin key molecule neurobiology migraine exact role brain serotonergic mechanisms remains matter controversy methods systematically searched pubmed studies investigating serotonergic system migraine brain either molecular neuroimaging electrophysiological methods results literature search resulted papers eligible review reviewed papers collectively support notion migraine patients alterations serotonergic neurotransmission likely migraine patients low cerebral serotonin level attacks elevates migraine attack conclusion review suggests novel methods investigating serotonergic system migraine brain warranted uncovering serotonergic mechanisms migraine pathophysiology could prove useful development future migraine drugs
fashion industry regarded responsible causing soil erosion water pollution large scale carbon dioxide emissions waste many production processes involves paper reports study explored concept future fashion uses materials grow directly natural renewable sources biofashion bacterial cellulose study various types bacterial cellulose studied evaluated green tea cellulose identified desirable fashion creation cellulosic pellicles green tea grown various culture solution concentrations incubation times compared optimal result theoretical practical framework established explore bacterial cellulose use fashion creation successful realization natural self grown fashion sgf tremendous creative practical potential well profound ecological effect fashion industry environment
emergency contraception form birth control considered women recent unprotected sexual intercourse reason women need emergency contraception use soon possible unprotected sex treatment reserved emergency situations used regular birth control birth control methods combined oral contraceptive pill effective preventing women becoming pregnant women presenting emergency contraception counselled need effective long term contraception medpharm
survivors acute lymphoblastic leukemia common cancer children increased risk developing late cardiometabolic conditions however mechanisms fully understood study aimed characterize plasma lipid profile apo distribution lipoprotein composition childhood survivors compared healthy controls results show despite young age survivors displayed dyslipidemia characterized increased plasma triglyceride ldl cholesterol well decreased hdl cholesterol survivors exhibited lower plasma apo higher apo levels along elevated apo iii ratios vldl fractions dyslipidemic survivors contained free cholesterol phospholipid moieties less protein differences apo content found survivors controls lipoprotein fractions except hdl hdl especially showed reduced apo raised apo leading depressed apo ratio analysis vldl apo disclosed trend higher apo iii content dyslipidemic survivors jlr conclusion thorough investigation demonstrates high prevalence dyslipidemia survivors highlighting significant abnormalities plasma lipid profile lipoprotein composition special attention must therefore paid subjects given atherosclerotic potency lipid lipoprotein disorders
paper presents use computer cluster heterogeneous computing components provide concurrency multi level parallelism coarse grain massive fine grain multiview video coding mvc applications mvc involves coding multiple video sequences taken scene different perspective addition motion estimation used conventional video coding single view video exploiting inter frame temporal similarities mvc adopts disparity estimation increase compression overcome huge computational cost associated extension attention mainly focused developing fast algorithms although fast algorithms bring substantial speedup achieve realtime mvc encoding requires acceleration coding process higher levels towards end paper proposes multiple view parallel multiple interleaved group pictures multiple igop scheduling scheme mvc evaluated eight views loss rate distortion performance proposed scheme outperforms view sequential coding factor respectively two popular prediction structures ibp ipp
nostalgia induced reminiscing positive past experience counteract loneliness promote prosocial behavior however process recalling thinking nostalgic experience quite different effects nostalgic experiences rarely reoccur people motivated savor prolonging time reminisce tendency savor experiences generalizes situations participants encounter later thus increasing consumer patience effect emerge however consumers must aware waiting beneficial attainment benefit moreover relationship nostalgia consumer patience diminished people perceive nostalgic experience repeatable intensify memory experience rather prolonging eight studies confirmed effects processes underlie
purpose aim study describe health related quality life hrqol persons ostomies explore influencing factors design secondary analysis data cross sectional survey subjects setting eight hundred twenty seven persons living ostomy enrolled provinces cities china october november final sample comprises individuals completed data collection mean age years range years methods health related quality life assessed using chinese language version city hope quality life ostomy questionnaire chinese version sociodemographic data clinical characteristics self efficacy adjustment ostomy social support psychological state patients measured general information questionnaire also administered stoma self efficacy scale ostomy adjustment inventory chinese version social support revalued scale hospital anxiety depression scale results ostomy patients overall hrqol ostomy patients moderate range mean score scores physical domain psychological domain social domain spiritual domains also moderate range respectively multivariate analysis found multiple factors influenced hrqol persons ostomy gender religious belief marital status psychological factors depression anxiety specific components related social support self efficacy ostomy care adjustment ostomy conclusion health related quality life among chinese patients fecal ostomies less optimal influenced multiple demographic psychosocial factors additional research needed design strategies improve hrqol population
cryptococcosis opportunistic fungal infection responsible high morbidity mortality immunocompromised patients combination antifungal substances promising way increase percentage successful treatment pedalitin ped natural substance obtained pterogyne nitens aim study verify efficacy ped alone combination amphotericin amb vitro vivo cryptococcus spp vitro assay minimum inhibitory concentrations mics amb ped found substances tested alone whilst combination treatment active concentration decreased mics amb ped survival assay fungal burden study histopathological assays possible study efficacy substances alone combination efficacy combination therapy considered better monotherapy evaluated galleria mellonella model amurine model thus combination ped amb interesting alternative anticryptococcal fungal treatment moreover correlation observed invertebrate murine models antifungal treatment combination elsevier international society chemotherapy rights reserved
according dichromatic reflection model previous methods specular reflection separation image processing often separate specular reflection single image using patch based priors due lack global information methods often completely separate specular component image incline degrade image textures paper derive global color lines constraint dichromatic reflection model effectively recover specular diffuse reflection key observation image pixel lies along color line normalized rgb space different color lines representing distinct diffuse chromaticities intersect one point namely illumination chromaticity pixels along color line spread entire image distances illumination chromaticity reflect amount specular reflection components global non local information color lines method effectively separate specular diffuse reflection components pixelwise way single image suitable real time applications experimental results synthetic real images show method performs better state art methods separate specular reflection
mindfulness based strategies show promise targeting construct impulsivity associated variables among problematic alcohol users study examined moderating role intervention mindfulness relaxation control trait impulsivity three outcomes examined post intervention negative affect positive affect urge drink among college students levels risk drinking moderation analyses revealed relationship baseline impulsivity primary outcomes significantly differed participants underwent mindfulness versus relaxation interventions notably simple slope analyses revealed negative urgency positively associated urge drink following mindfulness intervention among participants underwent relaxation intervention analysis simple slopes revealed negative urgency negatively associated urge drink positive urgency positively associated positive affect following relaxation intervention findings suggest level low high subscale impulsivity matter regard participant respond mindfulness versus relaxation intervention elsevier ireland ltd rights reserved
geotextiles porous fibrous materials consist randomly oriented isotropically distributed long filaments vary terms spatial distribution curvature orientation size mass density heterogeneous internal structure geotextiles constituted individual discrete fibers different micro structure macro structure properties prone exhibit dissimilar tensile stress strain behavior progressive versus reactionary well showing favorable versus adverse response varied experimental conditions temperature strain rate change tested macro scale opposed micro scale level end order evaluate thermo tensile strength properties well characterize tensile extension behavior single geotextile filaments micro scale level micro mechanical tensile tests performed different temperatures using dynamic thermo mechanical analyzer dma single filaments extracted polypropylene needle punched nonwoven geotextile various test temperatures degrees degrees chosen represent simulate wide range temperatures encountered field geotechnical applications landfill base liners paper also presents statistical analysis results test program provide basis comparison inherent filament variability elsevier ltd rights reserved
sub nyquist sampling based modulated wideband converter mwc innovative low rate sampling theory sparse wideband signals draws much attention researchers however research terms implementation theory far satisfactory paper present implementation scheme complete mwc sub nyquist sampling system proposed sampling system consists two parts lower machine mainly designed fpga four quadrant analog multiplier upper machine using computer lower machine responsible analog signal processing sampling rate far nyquist rate upper computer processes acquired data recovers original signals exhibit experiment results designed system especially provide waveforms pseudo random sequences mixed filtered signals captured oscilloscope give typical recovered results experimental results show proposed implementation method mwc system perfectly recover original wideband signal nyquist rate data music algorithm
integrating micro flood irrigation field rainwater harvesting irwh proposed experiments conducted production season parady experimental farm university free state south africa three water regimes dryland supplemental spi full irrigation tested runoff strip width rsw determine effects soil water balance components integrated irwh four blocks nine subplots prepared split plot factorial experimental design plots long standard width site specific data used estimate rainfall runoff deep drainage functions soil water content swc measured neutron water meter evapo transpiration partitioned evaporation transpiration using beta parameter deep drainage least significantly affected rainfalls less significantly higher gains change swc rsw dry spells rsws significantly higher swc deficit vegetative reproductive growth stages evaporation rsw constituted less compared less rsw rsw significantly higher irrespective water regime highest values irrigation treatments rsw therefore used either spi optimize soil water balance integrated irwh water management
objectives based premise internalized homonegativity product incorporation environmental heterosexism authors examined influence sociopolitical individual influences methods cross sectional study consisted gay bisexual men across countries results variables european country level associated higher levels included lack laws recognizing sex relationships perceived actual negative gay related public opinion homosexuals individual level variables significantly associated public opinion homosexuals exposure gay related victimization discrimination conclusions improved sociopolitical climate lgb individuals needed
present novel natural user interface framework called meta gesture selecting manipulating rotatable virtual reality objects egocentric viewpoint meta gesture uses gestures holding manipulating tools daily use specifically holding gesture used summon virtual object palm manipulating gesture trigger function summoned virtual tool contributions broadly threefold meta gesture first perform bare hand gesture based orientation aware selection manipulation small nail sized objects become possible combining stable palm pose estimator publicly available proposed static dynamic gesture estimator proposed novel random forest gesture estimator classify static gesture action status hierarchically single classifier novel voxel coding scheme called layered shape pattern configured calculating fill rate point clouds raw source data voxel top palm pose estimation allows dispensing need preceding hand skeletal tracking joint classification defining gesture experimental results show proposed method deliver promising performance even frequent occlusions orientation aware selection manipulation objects space wearing head mounted display attached egocentric depth camera see supplementary video available http ieeexplore ieee org
methodology predicting scaling membrane distillation considers thermodynamics kinetics fluid mechanics developed experimentally validated calcium sulfate theory predicts incidence scaling function temperature concentration flow conditions comparing nucleation induction time residence time applying experimental correction factor relevant residence time identified considering volume solution near membrane surface contains enough ions form nucleus critical size theory validated fouling experiments using calcium sulfate model sealant range temperatures degrees saturation indices flow rates although model validated bench scale system hoped compatible large scale systems may significant changes concentration temperature flow rate along flow direction lower temperatures saturation index high without scaling safe concentration limit decreases increasing temperature increasing feed flow rate reduces concentration polarization fluid residence time decrease likelihood fouling model translated easily readable maps outlining safe operating regimes theory maps used choose safe operating conditions wide range conditions system geometries
shortage water ancient greek civilizations necessitated various collection methods storage cisterns fact rainwater harvesting dates back minoan times since several types cisterns evolved significant development appears occurred throughout hellas hellenistic period addition hellenistic period succeeding roman byzantine venetian ottoman periods discussed within context examples relating characteristics hellenistic cisterns conveying illustrations development technology historical periods included
introduction one quarter human immunodeficiency virus hiv infected persons serbia also found hepatitis virus hcv infected general population hcv genotype shown prevalent one present first study distribution hcv genotypes among hiv hcv infected patients serbia relation epidemiological clinical features material methods study included hiv hcv infected group hcv mono infected patients period collection epidemiological clinical behavioral data using standardized questionnaire hcv genotyping level pure genotype performed reverse hybridization results intravenous drug use idu found significantly prevalent among infected patients hcv genotype detected patients mono infection compared patients infection genotypes significantly common among infected patients respectively multivariate logistic regression confirmed idu infection non hcv genotype hcv viral load log predictors hiv infection conclusions hcv genotypes found significantly prevalent among hiv hcv infected patients serbia compared hcv mono infected patients also prevalent compared european hiv hcv infected cohort history idu represents independent predictor hcv genotypes infection important implications treatment
korteweg vries kdv type equations describe shallow water waves stratified internal waves ion acoustic waves plasma physics lattice dynamics dimensional nizhnik novikov vesselov equations isotropic extensions kdv type equations paper investigate dimensional modified nizhnik novikov vesselov equations virtue binary bell polynomials bilinear forms multi soliton solutions backlund transformations derived effects parameters solitons monotonic function graphically illustrated observe coalescence two solitons collision region shapes change collision
microalgae one suitable subjects testing potentiality light microscopy image analysis size single cells endogenous chromaticity metabolic physiological characteristics microscope observations image analysis use microalgal cells lab cultures collected water bodies model investigate metabolic processes behavior reaction cells chemical photic stimuli dynamics population natural environment response changing conditions paper describe original microscope set together image processing techniques improved deal topics system detects recognizes focus cells extracts features measures cell concentration multi algal samples reconstructs swimming cell tracks monitors metabolic processes measure absorption fluorescent spectra subcellular compartments used digital microscopy station algal cell biology behavioral studies field analysis applications
transforming growth factor beta tgf beta stimulates extracellular matrix production considered master regulator tissue fibrosis including idiopathic pulmonary fibrosis radiation induced fibrosis recent study identified dysregulated mir expression pulmonary fibrosis however role mir tgf beta induced pulmonary fibrosis remains unclear study demonstrated tgf beta downregulates mir expression human lung fibroblast cell lines mir inhibits pro fibrogenic activities tgf beta decreasing expression offibronectin collagen type alpha alpha smooth muscle actin also identified transforming growth factor beta receptor tgfbr direct target mir knocking tgfbr lung fibroblasts significantly decreased tgfbr expression inhibited pro fibrogenic activities tgf beta expression mir insensitive tgfbr construct restored fibrogenesis induced tgf beta stimulation mir expressing cells therefore study suggests important role mir fibrotic lung diseases indicates mir potent therapeutic microrna treating pulmonary fibrosis
social anxiety disorder sad highly prevalent yet frequently undetected untreated psychological disorder adolescents untreated sad often follows chronic course associated social impairment poor educational attainment diminished quality life high rates comorbidity barriers treatment include low socioeconomic status minority status difficulty detecting internalizing symptomatology poor public awareness nature signs sad present study aimed identify predictors treatment utilization sad adolescents among nationally representative sample adolescents hierarchical logistic regression performed demographic variables entered first block comorbid mood anxiety eating substance use disorders entered second block comorbid externalizing disorders entered final block results study indicate lower rates receiving treatment predicted hispanic ethnicity extreme poverty higher rates receiving treatment significantly predicted presence comorbid diagnoses including depression another anxiety disorder eating disorder adolescents sad presence comorbid adhd significant predictor service receipt comorbid disorders sociodemographic variables results highlight priorities expanded healthcare policy improve recognition service use sad identify key aspects research developed elsevier ltd rights reserved
background accurate diagnosis patients presenting lesions various locations within visual pathway challenging study investigated functional structural changes secondary lesions identify patterns useful guide early effective management methods records patients referred optic nerve head assessment reviewed patients final diagnosis likely neuropathic lesions posterior eye included current study fundus photographs optic coherence tomography images visual field tests evaluated changes respect retinal nerve fibre layer topography prediction structure function paradigms emerging clinical patterns examined consistency likely anatomical origin underlying insult presence varying diagnoses results data patients lesions along visual system allowed identification retinal nerve fibre layer asymmetry correlated visual field defects ganglion cell analysis bilateral discordance retinal nerve fibre loss easily discernible altered pattern temporal superior nasal inferior temporal curve characteristic post chiasmal lesions sometimes subtle changes supported diagnosis cases multiple aetiologies ambiguous visual field analysis ganglion cell loss conclusion intricate knowledge retinal architecture projections allows coherent predictions functional structural deficits following various lesions affecting visual pathway integration adjunct imaging retinal nerve fibre layer thinning assist clinicians guide clinical investigations toward likely diagnosis light significant individual variations case series presented study aids differential diagnosis retrograde optic neuropathies using retinal nerve fibre layer asymmetric patterns important clinical marker
help boussinesq perturbation expansion new basic equation describing long small amplitude unidirectional wave motion shallow water surface tension derived fourth order namely higher order korteweg vries kdv equation procedure deriving equation assumes relation small parameter measures ratio wave amplitude undisturbed fluid depth small parameter measures square ratio fluid depth wave length taken form small dimensionless parameter order amplitude motion hirota bilinear method used investigate one two soliton solutions new higher order kdv equation
paper examined prevalence depressive symptomotology among women mexican ancestry age diverse incomes nativity examined differences rates diagnosis spanish english preference sensitivity specificity three common measures patient health questionnaire phq kessler psychological distress scale depression questions composite international diagnostic interview short form mdd cidi phq used gold standard measure results indicated participants met criteria depression higher rates found among spanish preference participants significantly higher sensitivity lower specificity mdd cidi items respectively study suggests mdd cidi measures complementary screening depressive symptomatology implications cultural linguistic assessment depression discussed
background data lacking national trends atrial fibrillation hospitalization particularly regard long term outcomes including readmission mortality methods studied medicare fee service beneficiaries evaluated rates hospitalization hospital mortality length stay hospital payments evaluated rates long term outcomes including day readmission day mortality year mortality evaluate changes rates hospitalization mortality used mixed effects models adjusting age sex race comorbidity assess changes rates day readmission constructed cox proportional hazards model adjusting age sex race comorbidity results adjusted rates hospitalization increased approximate per year although geographic variation present trend consistent nationwide median hospital length stay remained unchanged interquartile range days median medicare inpatient expenditure per beneficiary increased interquartile range interquartile range per stay period rate inpatient mortality hospitalization decreased per year rate day readmission decreased per year rates day year mortality decreased modestly per year respectively conclusions among medicare fee service beneficiaries patients hospitalized frequently treated costly inpatient therapies catheter ablation finding associated improved outcomes including lower rates hospital mortality day readmission day mortality year mortality
access control model based security plays crucial role security cloud computing one emerging challenging fields implementation explained paper issues related cloud security tried resolve extent using access control model security encryption also part access control based model also incorporated better security role based access control rbac model along aes rsa encryption algorithm implemented achieve efficient security main aim work design framework uses cryptography concepts store data cloud storage allowing access data using role perspective smallest amount time cost encryption decryption processes
experiencing unprecedented movement away coal lesser degree oil burdened low income communities people color could experience health benefits reductions air water pollution yet groups could suffer harm transitions lack broad public input policies prioritize elite corporate interests paper highlights energy transitions build contribute environmental injustices energy justice requires ending disproportionate harm also entails involvement design solutions fair distribution benefits green jobs clean air extent confluence state civic market processes assure transitions clean low carbon energy production involving equitable distribution costs benefits decision making power explore question assess trends fossil fuel divestment carbon taxes social cost carbon measurements cap trade renewable energy energy efficiency current research demonstrates opportunities pitfalls area mixed partial energy justice consequences leading call greater attention specifics distributive justice procedural justice recognition justice research policy action illustrative energy transition case studies suggest feasibility benefit empowering approaches also indicate conflict green evident though stark inequities clean energy initiatives identify positive pathways forward compile priorities energy justice research agenda based interactive participatory practices aligning advocacy activism academics
since development combined oral contraceptives years ago significant innovations occurred domain progestin evolving knowledge progestin mechanism action physiology allowed development novel progestins limited steroid receptor cross reactivity decreased side effect profiles pharmacokinetics optimized modern delivery systems review summarizes current knowledge progestin physiology modern delivery systems developments progestin agonists antagonists contraception
objective reality uneven water resource distribution imbalanced water demand human society makes inevitable transfer water age old method adopt inter basin water transfers ibts alleviating even resolving urgent demand water deficient areas number countries made attempts achieved enormous benefits however ibts inevitably involve redistribution water resources relevant basins may cause changes ecological environment different basins changes two sided namely positive impacts including adding new basins water deficient areas facilitating water cycle improving meteorological conditions recipient basins mitigating ecological water shortage repairing damaged ecological system preserving endangered wild fauna flora well negative impacts including salinization aridification donor basins damage ecological environment donor basins sides conveying channel system increase water consumption recipient basins spread diseases etc ibts enormous ecological risk necessary comprehensively analyze inter basin water balance relationship coordinate possible conflicts environmental quality problems regions strengthen argumentation ecological risk water transfer eco compensation measures addition effective alternative measures ibts attaching importance water cycle improving water use efficiency developing sea water desalination rainwater harvesting technology etc
introduction peptidyl arginine deiminase pad enzyme plays important role gene expression turning genetic code functional products body involved key post translational modification involves conversion arginine citrulline regulates various processes apoptosis innate immunity pluripotency dysregulation great impact genesis various diseases last years pad emerged potential therapeutic target treatment rheumatoid arthritis areas covered review discuss basic structure function pad along role altered pad activity onset maladies also elucidate role pad variants etiology among several ethnic groups current pre clinical inhibitors regulate pad expert opinion citrullination crucial role several disorders since pad initiator citrullination important therapeutic target inflammatory diseases therefore depth knowledge roles activity pad required explore effective ways conquer pad related ailments especially
telemedicine use telecommunications technology support health care distance dermatology relies visual cues easily captured imaging technologies making ideally suited care model advances telecommunications technology made possible deliver high quality skin care patient provider separated time space recently mobile devices connect users cellular data networks enabled teledermatologists instantly communicate primary care providers throughout world availability teledermoscopy provides additional layer visual information enhance quality teleconsultations teledermatopathology become increasingly feasible advances digitization entire microscopic slides robot assisted microscopy barriers additional expansion services include underdeveloped infrastructure remote regions fragmented electronic medical records varying degrees reimbursement teleconsultants also confront special legal ethical challenges work toward building global network practicing physicians
objective evaluate longitudinal changes inflammatory markers predict cardiovascular disease events among smokers making quit attempt characterize cross sectional associations smoking smoking heaviness approach results longitudinal cohort study contemporary smokers evaluated independent associations smoking heaviness markers exhaled carbon monoxide cigarettes pack years inflammatory markers reactive protein dimer fibrinogen urinary isoprostane creatinine ratio white blood cell wbc count myeloperoxidase effects smoking cessation continued smoking inflammatory markers year among smokers made aided quit attempt part randomized comparative effectiveness trial standard care strong independent associations smoking heaviness markers ratio wbc myeloperoxidase adj high sensitivity reactive protein dimer fibrinogen participants mean years old women non white smoked cigarettes pack years year successful abstainers gained weight versus pounds larger increases insulin resistance scores continuing smokers despite increases abstainers significant decreases ratio wbc counts changes markers related quitting conclusions smoking heaviness associated increased ratio myeloperoxidase wbc counts cessation improves ratio wbc counts independent weight change suggesting reduced inflammation related less oxidant stress
paper evaluates results large scale geosynthetic reinforced soil grs column load tests also known performance tests mini pier tests study effect tensile strength vertical reinforcement spacing facing elements backfill properties deformations grs kpa typical bridge bearing pressures also kpa results indicate grs performs well service conditions semi empirical expression proposed prescribed bearing pressures limit vertical strain abutment height addition recommendations estimating lateral deformation grs bridge abutments also provided kpa surcharge series tests vertical settlements ranged axial strain lateral deformations ranged lateral strain reinforcement strain ranged less construction less loading lateral deformation results indicate maximum displacement occurs top third region wall face comparing vertical lateral displacement data shows grs models experienced negligible positive volume changes typical bridge service loads published elsevier ltd
paper investigate dimensional generalized variable coefficient kadomtsev petviashvili equation describe nonlinear phenomena fluids plasmas painleve analysis performed study integrability find equation completely integrable virtue binary bell polynomials bilinear form soliton solutions obtained backlund transformation binary bell polynomial form bilinear form derived soliton collisions graphically discussed solitons keep original shapes unchanged collision except phase shifts variable coefficients seen affect motion solitons variable coefficients chosen constants solitons keep directions unchanged collision variable coefficients functions temporal coordinate one soliton changes direction
principles negative reinforcement learning may play critical role etiology treatment depression examined integrity positive reinforcement learning congenitally helpless rats animal model depression using random ratio schedule devaluation extinction procedure furthermore tested whether antidepressant dose monoamine oxidase mao inhibitor deprenyl would reverse deficits positive reinforcement learning found rats impaired acquisition even simple operant contingencies fixed interval schedule rats exhibited apparent deficits appetite reward sensitivity reacted devaluation food manner consistent dose response relationship reinforcer motivation assessed lever pressing across sessions progressively decreasing reward probabilities highest congenitally non helpless cnh rats long reward probabilities remained relatively high cnh compared wild type rats also resistant extinction across sessions compared saline deprenyl reduced duration immobility rats forced swimming test indicative antidepressant effects restore deficits acquisition schedule conclude positive reinforcement learning impaired rats bred helplessness possibly due motivational impairments deficits reward sensitivity deprenyl exerted antidepressant effects reverse deficits positive reinforcement learning ibro published elsevier ltd rights reserved
boredom typically regarded nuisance past research boredom depicts common emotion correlate many detrimental psychological social factors including addiction depression discrimination aggression present nuanced perspective boredom specifically propose test state boredom serves important self regulatory function potential foster positive interpersonal consequences signals lack purpose activity fosters search meaningful engagement examined whether boredom subsequently cause prosocial intentions corresponding prosocial behavior seen purposeful predicted boredom characterized search meaning pilot study promoted prosocial intentions experiment particular corresponding behavior seen highly meaningful experiment novel findings suggest boredom desirable consequences recasts emotion merely good bad rather personally socially functional
high gain two stage cmos operational amplifier structural simplicity classical widlar architecture presented differential input stage proposed operational amplifier modified incorporating inverse aspect ratio self cascode structures biased operate subthreshold region minimize classical compensation capacitor results considerable saving occupied chip area spice simulations cmos technology supply carried compare performance proposed operational amplifier previously reported designs proposed operational amplifier demonstrated better gain bandwidth product mhz low power consumption occupied smaller chip area
paper reports study spatial characteristics rain rates recorded basque region northern spain perform study network eighty raingauges spread throughout region used statistical parameters spatial cross correlation coefficient space time cross correlation coefficient calculated evolution separation distance studied hoped information reported could useful better understanding characteristics rain developing countermeasures terrestrial satellite radio networks operating frequencies ghz
many diode based equivalent circuits simulating electrical behaviour photovoltaic cells panels reported scientific literature two diode equivalent circuits require complex procedures calculate seven model parameters less numerous model parameters generally calculated using data extracted datasheets issued panel manufactures adopting simplifying hypotheses numerical solving techniques criterion rating usability accuracy two diode models proposed paper aim supporting researchers designers working area systems select use model may fit purpose criterion adopts three level rating scale considers ease finding data used analytical procedure simplicity mathematical tools needed perform calculations accuracy achieved calculating current power analytical procedures simplifying hypotheses operative steps calculate parameters famous two diode equivalent circuits exhaustively described paper accuracy models tested comparing characteristics issued panel manufacturers current voltage curves constant solar irradiance cell temperature calculated analysed models results study show two diode models recently proposed reach accuracies comparable values derived one diode models
background many ways treat focal hyperhidrosis including surgeries palmar axillary hyperhidrosis however doctors patients tend reluctant perform surgery plantar hyperhidrosis due misconceptions prejudices surgical treatment addition studies reported outcome surgeries plantar hyperhidrosis therefore objective study determine outcome early late postoperative satisfaction complication compensatory hyperhidrosis recurrence rate efficiency surgical treatment plantar hyperhidrosis materials methods august october lumbar sympathetic block lsb performed patients plantar hyperhidrosis using clipping method limited video assisted lsb performed using ligamax clip horizontal clip identifying sympathetic ganglion finger touch endoscopic vision results patients male female mean age years range years mean follow time months mean early postoperative satisfaction score day postoperative evaluation month later mean late postoperative satisfaction score significant difference early postoperative satisfaction score clipping level however late postoperative satisfaction score significantly better group group patient age body mass index affect satisfaction score however male patients patients history hyperhidrosis operation showed higher satisfaction score others conclusion limited video assisted lsb using clip provided good results minimal complications low compensatory hidrosis contrary prejudice toward therefore surgical treatment recommended plantar hyperhidrosis
study examined effects aerobic resistance training combination health related quality life hrqol adolescents overweight obesity week run period males females post pubertal adolescents aged years randomized groups weeks aerobic training resistance training combined aerobic resistance training nonexercising control participants received dietary counseling daily energy deficit kcal indicators hrqol overall hrqol physical psychosocial aggregate emotional social school functioning hrqol baseline months postintervention measured pediatric quality life questionnaire trial began march completed june intention treat analyses groups showed significant improvements months hrqol indicators aerobic group showed greater improvements controls physical hrqol mean differences participants adherence combined training produced greater improvements control overall hrqol mean differences physical hrqol mean differences social hrqol mean differences school based hrqol mean differences findings highlight potential importance including resistance exercise traditional aerobic exercise programs maximize hrqol adolescents obesity
objective determine percentage victorians history notified hepatitis exposure received appropriate follow diagnostic services methods individual notification data aggregate medicare supplementary testing data entered compartmental transition model used estimate percentage people hepatitis notification yet receive either negative diagnostic test viral nucleic acid test viral genotype end results estimate uncertainty interval victorians hepatitis notification receive either negative test viral nucleic acid viral genotyping test study period end estimate approximately victorians living hepatitis antibodies yet receive testing approximately would aged years older conclusions majority people living hcv antibodies victoria received appropriate secondary diagnostic services end implications improved therapeutic options become available people living chronic hepatitis measures support appropriate follow people suspected confirmed chronic infections via primary care services required
fast marching method widely used numerical method solving eikonal equation arising variety scientific engineering fields long deemed inherently sequential efficient parallel algorithm applicable large scale practical applications available literature study present highly scalable massively parallel implementation fast marching method using domain decomposition approach central algorithm novel restarted narrow band approach coordinates frequency communications amount computations extra sequential run achieving unprecedented parallel performance within restart narrow band fast marching method executed simple synchronous local exchanges global reductions adopted communicating updated data overlapping regions neighboring subdomains getting latest front status respectively independence front characteristics exploited special data structures augmented status tags extract masked parallelism within fast marching method efficiency flexibility applicability parallel algorithm demonstrated several examples problems extensively tested six grids billion points using different numbers processes ranging remarkable parallel speedups achieved using tens thousands processes detailed pseudo codes sequential parallel algorithms provided illustrate simplicity parallel implementation similarity sequential narrow band fast marching algorithm elsevier inc rights reserved
introduction large proportion deaths many illnesses attributed three modifiable risk factors tobacco use overweight obesity physical inactivity health risk assessments hras widely available online consistently used healthcare systems activate patients participate prevention programs aimed improving lifestyle behaviors objectives goal study test whether adding telephone based coaching use comprehensive hra increases risk patients activation enrollment prevention program compared hra use alone methods participants randomized either complete hra alone conjunction telephone coaching intervention eligible veterans least one modifiable risk factor current smoker overweight obese physically inactive primary outcome enrollment participation prevention program months secondary outcomes include change patient activation measure framingham risk score discussion study first test web based health risk assessment coupled health coaching intervention within large healthcare system results study help veterans health adininistration vha implement national plan include comprehensive health risk assessments tool engage veterans prevention results also inform health systems outside vha seek implement medicare advisement health risk assessment become mandatory component care affordable care act published elsevier inc
study examines digital equity cultural context many studies used classic analytical variables socioeconomic status gender investigate problem unequal access recently differences use information communication technology ict studies explored cultural variables usually focused theory considered culture background dimension study central thesis cultural context plays crucial role shaping parents ictrelated child rearing practices case study chinese students share confucian heritage hong kong demonstrate importance cultural dimensions students ict use examine cultural values associated digital equity findings reveal confucian values influence aspects family social relationships particular whether students receive adequate appropriate ict resources use ict effectively essential aspects digital equity
background although financing represents critical component health system strengthening also defining concern efforts move towards universal health coverage many countries lack tools capacity plan effectively service scale part multi country collaborative study emerald project set develop test apply fully integrated health systems resource planning health impact tool mental neurological substance use mns disorders methods new module existing strategic planning onehealth tool developed identifies health system resources required scale range specified interventions mns disorders also projects expected health gains population level conducted local capacity building use well stakeholder consultations tested calibrated model parameters applied tool three priority mental neurological disorders psychosis depression epilepsy six low middle income countries results resource needs scaling mental health services reach desired coverage goals substantial compared current allocation resources six represented countries large absolute terms four emerald study countries ethiopia india nepal uganda cost delivering key interventions psychosis depression epilepsy existing treatment coverage estimated per capita total population per year nigeria south africa comparison projected cost per capita target levels coverage approaches per capita nigeria south africa ranges four countries implementation package care target levels coverage expected yield healthy life years per one million populations represents substantial health gain currently neglected underserved sub populations suffering psychosis depression epilepsy conclusions newly developed validated module onehealth tool used especially within context integrated health planning national level generate contextualised estimates resource needs costs health impacts scaled mental health service delivery
used treatment world emergency contraception levonorgestrel lng pill however efficacy decreases administered days unprotected sexual intercourse whereas ulipristal acetate upa pill effective days afterwards pooled clinical data show upa effective lng taken shortly intercourse within conversely intercourse upa also effective lng inhibiting follicular rupture administered near time ovulation show overall upa effective lng reducing rate unwanted pregnancies demonstrating effect product depending follicular size time unprotected sexual intercourse also explain difference upa lng maximum time administration simply shift ovulation fact upa effect larger follicles lng without postulating hypothetical endometrial effect also explain upa lng remain emergency contraceptives used daily contraception elsevier masson sas rights reserved
due higher attenuation switching frequency current harmonics lcl filter widely used grid connected inverters deal resonance lcl filter capacitor current usually fed back damp resonance actively however computation pulsewidth modulation pwm delays digital control system significant influence active damping method resulting poor system robustness meanwhile delays also reduce control bandwidth greatly thus impose severe limitation low frequency gains paper real time computation method dual sampling mode proposed remove computation delay inner active damping loop outer grid current control loop simultaneously thus system robustness control performance greatly improved moreover time duration sampling instant switching transition inverter bridge extended proposed method effectively prevents switching noise distorting sampled signals therefore noise immunity inverter also improved greatly experimental results lcl type single phase grid connected inverter confirm theoretical expectations effectiveness proposed method
abilities stabilize focus attention notice attention lapses return attention intended object following lapses precursors mindfulness individuals diagnosed attention deficit hyperactivity disorder adhd deficient attentional self control skills characterize mindfulness present study assessed relationship mindfulness adhd young adults using mindful attention awareness scale maas computerized task test variables attention tova world health organization adult self report scale asrs tool used adult adhd screen beck anxiety inventory bai beck depression inventory bdi recruited adult volunteers ages confirmed adhd diagnoses control participants overall participants prior diagnoses adhd scored lower maas controls asrs scores strongly negatively correlated maas scores attention performance index response time response time variability subscales tova positively correlated maas scores negatively correlated asrs scores intrasubject response time variability tova parameter associated attention lapses also strongly negatively correlated maas scores overall participants self reported mindfulness measured maas strongly related self reports clinical measure attention disorders anxiety depression multiple indices concentration mind wandering standardized task tova
monodispersed titanium oxide nanospheres synthesized via controlled hydrolysis method study firstly rapid mixing method used situ oxidation polymerize aniline modify surface titanium oxide nanospheres form core shell nanostructure scanning electron microscopy sem transmission electron microscopy tem ray diffraction xrd rotational viscometer used investigate structure morphology properties different type dosage surfactants different acids crystal forms titanium oxide different dosages aniline studied analysis impact tio pani nanocomposites suitable type dosage surfactants ratio aniline titania key synthesize nanocomposite include nanoring nanofiber nanoparticles core shell composite depending synthesis condition titania polyaniline composite showed typical electrorheological behavior demonstrated potential applications smart material elsevier ltd rights reserved
landsat data increasingly used ecological monitoring research data often require preprocessing prior analysis account sensor solar atmospheric topographic effects however ecologists using data faced literature containing inconsistent terminology outdated methods vast number approaches contradictory recommendations issues best make determining correct preprocessing workflow difficult time consuming task worst lead erroneous results address problems providing concise overview landsat missions sensors clarifying frequently conflated terms methods preprocessing steps commonly applied landsat data differentiated explained including georeferencing registration conversion radiance solar correction atmospheric correction topographic correction relative correction synthesize information presenting workflows decision tree determining appropriate level imagery preprocessing given ecological research question emphasizing need tailor workflow study site question hand recommend parsimonious approach landsat preprocessing avoids unnecessary steps recommend approaches data products well tested easily available sufficiently documented focus specific ecological applications landsat data yet many concepts recommendations discussed also appropriate disciplines remote sensing platforms
discovery jakvf mutation present polycythemia vera myelofibrosis patients opened way new era targeted therapies myeloproliferative neoplasms ruxolitinib first class janus kinase jak inhibitor approved management diseases patients conventional treatment strategies including aspirin phlebotomy cytoreductive agents hydroxyurea interferon clearly provide clinical benefits however patients develop resistance intolerance treatments ruxolitinib approved patients resistant intolerant hydroxyurea based results phase response study study showed ruxolitinib improves hematocrit control reduces splenomegaly ameliorate disease related symptoms compared best available therapy patients curative treatment allogeneic stem cell transplantation remains restricted limited group patients poor prognosis eligible procedure associated non negligible transplant related mortality treatments palliative unlikely prolong survival ruxolitinib approved united states patients intermediate high risk disease europe disease related splenomegaly symptoms adults based phase comfort comfort studies studies showed ruxolitinib able reduce splenomegaly ameliorate symptoms improve survival however journey finished yet since still important unmet needs patients including improvement cytopenias significant modification disease natural history
effects low impact development lid practices urban runoff pollutants proven positive many studies however effectiveness lid practices vary depending different urban patterns present study performance lid practices explored three land uses different urban forms compact high density urban form conventional medium density urban form conservational medium density urban form soil water assessment tool swat used model development performed reflect hydrologic behavior application lid practices rain gardens permeable pavements rainwater harvesting tanks considered simulations modeling procedure representation lid practices swat specifically illustrated context simulations done land use results compared evaluated application lid practices demonstrated decrease surface runoff pollutant loadings land uses different reductions represented response land uses different urban forms watershed scale addition results among post lids scenarios generally showed lower values surface runoff nitrate compact high density urban land use total phosphorus conventional medium density urban land use compared land uses suggest effective strategies implementing lid practices
importance open data benefits offer received recognition international stage signing open data charter june charter early focus high value areas including transport education governments greater influence seen funding open data institute odi remit support small medium sized enterprises smes identifying benefits using open data whereas within open data discussion infancy although acknowledged sector challenge russell group universities evident need academic community influence adoption applications using linked open data techniques data management service delivery article introduces concept data autodiscovery highlighting role organisation profile document opd contribution early success national equipment portal equipment data along discussing need greater dialogue linked open data standards development
emergency contraception important fight reduce incidence unplanned pregnancy unnecessary abortion prevalence unplanned pregnancy among young people including university students increasing negative socioeconomic implications students universities country study therefore assessed knowledge attitude students towards use emergency contraception two hundred ninety female students residing university campus systematically selected participate study data collected using self administered questionnaire majority knew emergency contraception fifty percent study participants know emergency contraception used students think emergency contraception harmful reported pregnancies unplanned resulting abortions sexually active students trying get pregnant never used type contraception seventy percent students said emergency contraception likely prevent pregnancy unprotected sex sixty percent interviewed stated likely use emergency contraception next time think risk falling pregnant knowledge sources free emergency contraception remains poor among students strategies promote use emergency contraception focused improving knowledge access proper use better effectiveness
implementation efficient multigrid preconditioners elliptic partial differential equations pdes challenge due complexity resulting algorithms corresponding computer code sophisticated mixed finite element discretisations unstructured grids efficient implementation time consuming requires programmer depth knowledge mathematical theory parallel computing optimisation techniques manycore cpus paper show development bespoke multigrid preconditioners simplified significantly using framework allows expression component algorithm correct abstraction level approach allows expression finite element problem language close mathematical formulation problem guarantees automatic generation efficient execution parallel optimised low level computer code flexible enough support different abstraction levels give programmer control details preconditioner use composable abstractions firedrake pyop package demonstrate efficiency approach solution strongly anisotropic pdes atmospheric modelling weak formulation pde expressed unified form language ufl lower pyop abstraction layer allows manual design computational kernels bespoke geometric multigrid preconditioner compare performance preconditioner single level method hypre boomeramg algorithm firedrake pyop code inherently parallel present detailed performance analysis single node cores archer supercomputer implementation utilises significant fraction available memory bandwidth shows good weak scaling compute cores elsevier inc rights reserved
redox flow battery rfb one promising large scale energy storage technologies massive utilization intermittent renewables especially wind solar energy work presents novel redox flow battery utilizes inexpensive abundant iii redox couples redox materials experimental results show iii redox couples fast electrochemical kinetics methanesulfonic acid coulombic efficiency energy efficiency battery respectively high furthermore battery exhibits stable performance terms efficiencies discharge capacities cycle test inexpensive redox materials fast electrochemical kinetics stable cycle performance make present battery promising candidate large scale energy storage applications elsevier rights reserved
wearable electronics bring new challenges joining technologies electrical connections must fully support functionality product time deliver comfort user connections durability expected textile materials ability withstand repeated flexure wear rigours laundering however decade launch first commercial product despite numerous advances joining technologies field perceived still development
study novel immittance simulator circuit proposed proposed circuit simulate one floating positive negative inductor simulator positive negative capacitor simulator positive negative resistor simulator uses one current backward transconductance amplifier cbta two grounded passive components proposed simulator tuned electronically changing transconductance value cbta moreover circuit require conditions component matching good sensitivity performance respect tracking errors passive components performance proposed immittance simulator demonstrated fourth order voltage current mode band pass filters using pspice simulations based tsmc level cmos technology parameters elsevier gmbh rights reserved
designing environmentally friendly buildings provide high performance cost savings increasing interest development sustainable cities today looking buildings certification sustainable practices beyond ratings satisfy social responsibilities construction industry general benefit integrated tool help optimize selection process materials equipments systems every stage proposed building life building information modeling bim potential aid designers select right type materials early design stage make vital decisions great impacts life cycle sustainable buildings paper describes methodology integrates bim canadian green building certification system leed also explains integration would assist project teams making sustainability related decisions accumulating required number points based applied green building rating system methodology depicts implementation model automatically calculates compiled number leed certification points related registration costs green certified materials used designing sustainable buildings within concepts bim using bim methodology help designers invent animate sustainable buildings mode easily efficiently conceptual stage design information proposed sustainable building produced timely manner using new plug ins developed reason link bim model external database stores sustainable materials assembly groups real case project presented illustrate usefulness capabilities proposed model elsevier ltd rights reserved
data developing countries period used study gendered impact country level conditioning financial environment government quality support education quality entrepreneurship know innovation environment support business infrastructure entrepreneurial culture society gender roles choice made early stage entrepreneurs regarding routine level sector activity starting business lower routine levels linked higher economic growth business infrastructure country core factor facilitating entry medium low routine sectors followed education quality entrepreneurship know women entrepreneurs benefit larger extent innovation environment support gender roles may deter entry medium low routine sectors
ownership smartphone never easier nowadays supported fact people around smartphone equivalent smart device smartphone smart smartphone definition name suggests phone smart enough limited features capabilities traditional cellular phone also perform smart device recent years device deemed intelligent device computer advance piece technology commercially available general public opinion revolutionized societies today work hence makes smartphone mobile operating system built upon similar computer becoming common sight nowadays offered price people able afford hence reaching hands ceiling lower income families way higher income families back pure play devices mostly simple terms function works hence possible could suggest security aspect never rather never issue alteration data operation tape video recorders images captured never process sense interruptions operation likely clear visible nowadays combine devices complex entity tend leave hole cloth somewhere rather see due overwhelming amount things paper discuss current state commercially available operating systems two biggest names smart devices namely ios android measure secure vulnerable susceptible malwares nature mobile hoc network first analyze integrity core smart device operating system use evaluate effectiveness techniques defenses preventing identifying malwares
successful memory retrieval predicated recognizing old information also correctly rejecting new information lures order avoid false memories correctly rejecting lures difficult perceptually semantically related information presented study compared lures distinct previously studied information behavioral difference suggests cognitive neural basis correct rejections differs respect relatedness lures studied items present study sought identify neural activity aids suppressing false memories examining network brain regions underlying correct rejection related unrelated lures results showed neural overlap right hippocampus anterior parahippocampal gyrus associated related unrelated correct rejections indicating neural regions support correctly rejecting lures regardless semantic perceptual characteristics direct comparisons related unrelated correct rejections showed unrelated correct rejections associated greater activity bilateral middle inferior temporal cortices regions associated categorical processing semantic labels related correct rejections showed greater activation visual lateral prefrontal cortices associated perceptual processing retrieval monitoring thus related unrelated correct rejections show common neural correlates related correct rejections driven greater perceptual processing whereas unrelated correct rejections show greater reliance salient categorical cues support quick accurate memory decisions
background aimsbarriers linked drug control systems considered contribute inequitable access controlled medicines leaving millions people pain suffering studies focus access opioids treatment severe cancer pain study aims identify specific access barriers patients opioid dependence legislation regulations central eastern european countries methodsthis study builds previous analysis legislation regulations part framework access opioid medication europe atome project depth analysis undertaken determine specific barriers patients opioid dependence need opioid analgesics opioid agonist therapy oat country number nature specific potential barriers patients assessed according eight categories prescribing dispensing manufacturing usage trade distribution affordability penalties additional keyword search conducted minimize omission barriers barriers additional category language recorded qualitatively countries included bulgaria cyprus estonia greece hungary latvia lithuania serbia slovakia slovenia turkey resultsten countries except estonia showed specific potential barriers legislation regulations total number barriers varied two slovenia lithuania number categories varied one slovenia five lithuania specific potential barriers shown categories prescribing usage total number single category varied one lithuania prescribing individual differences countries specific potential barrier shown example variation minimum age criteria admission oat ranging lithuania special cases years greece countries stigmatizing language legislation conclusionspatients opioid dependence likely experience specific barriers accessing opioids addition experienced non dependent patients
urban stormwater runoff significant pollution source potentially valuable resource study compares stormwater management two cities singapore berlin germany comparing strategies stormwater management illustrate differences geography land water availability urban infrastructure regulatory regimes legislation intensives two cities led different solutions stormwater management singapore faced serious issue water scarcity placed increasing emphasis stormwater management developing comprehensive network drains canals mainly aim controlling flooding potable water supply contrast berlin concerns protection surface water quality non potable water supply urban areas resulted shift management goals towards low impact solution based source control cost analysis indicated decentralized rainwater harvesting practiced berlin leads higher economic efficiency potable water substituted stormwater compared centralized drainage system singapore additionally green roofs result energy savings serving mitigation strategies effect urban heat islands global warming near future envisioned combination conventional decentralized urban stormwater management prove practical solution cities
east west divide contraceptive use patterns identified across europe western european countries characterized widespread use modern contraception central eastern european countries characterized high prevalence withdrawal rhythm method abortion building ready willing able framework study aims gain insight micro macro level socioeconomic cultural technological determinants underlying contraceptive use data generations gender survey covering four western seven central eastern european countries used multinomial multilevel analyses performed results reveal individuals intend delay parenthood likely use contraceptive method whereas holding traditional values lower socioeconomic status associated higher likelihood using traditional methods regional reproductive rights gender equality interact complex ways associations minimum results underline complexity processes underlying persistent difference contraceptive use across europe
aim amyloid beta beta mediated neurotoxicity plays pivotal role pathogenesis alzheimer disease induces oxidative stress apoptosis linalool volatile monoterpene showing positive effect treatment study designed research protective effect neurotoxicity cognitive deficits induced beta mice main methods beta solution injected bilateral hippocampus induce cognitive deficits mice protective effects evaluated behavioral tests related mechanism explored observing apoptosis oxidative stress changes hippocampus mice key findings administration significantly improved cognitive performance model mice morris water maze test step test meanwhile effectively reversed beta induced hippocampal cell injury histological examination apoptosis tunel assay changes oxidative stress indicators sod gpx ache besides activated cleaved caspase caspase caspase suppressed nrf expression elevated treatment significance could attenuate cognitive deficits induced beta neuroprotective effect might mediated alleviation apoptosis oxidative stress depending activation nrf signaling could assume potential neuroprotective substance therapy elsevier inc rights reserved
objective best material choice cranioplasty following craniectomy remains subject discussion complication rates cranioplasty tend high computer assisted dimensional modelling polyetheretherketone peek recently introduced cranial reconstruction aim study evaluate patient surgery related characteristics risk factors predispose patients cranioplasty complications material methods retrospective study included total cranial peek implants patients performed two reference centers netherlands complications registered patient surgery related data carefully analysed results overall complication rate peek cranioplasty complications included infection postoperative haematoma cerebrospinal fluid leak wound related problems postoperative infections required removal implant nonetheless removed implants could successfully used sterilization conclusion although overall complication rates peek cranioplasty remain high outcomes satisfactory results compare favourably recent literature reports cranial vault reconstruction european association cranio maxillo facial surgery published elsevier ltd rights reserved
background congenital hypothyroidism common preventable cause intellectual disability early diagnosis difficult without newborn screening genetic environmental factors race ethnicity sex pregnancy outcomes noted risk factors study aimed determine incidence among different ethnic groups capital macedoina multiethnic city methods year retrospective cohort analysis performed newborns capital macedonia skopje screened whole blood thyroid stimulating hormone tsh dry blood spots collected birth period tsh value miu used cutoff point miu thereafter results primary detected newborns female male ratio overall incidence incidence primary significantly increased lowering tsh cutoff value primarily due detected neonates transient period ethnic differences incidence primary detected incidence among roma neonates significantly higher incidence detected macedonians albanians conclusions increased incidence roma newborns detected compared ethnicities capital macedonia analysis factors direct interrelationship increased incidence roma newborns well elucidation impact incidence ethnicity overall incidence skopje warranted
lower limb vascular amputations represent serious problem vascular care consequence critical limb ischemia often associated diabetes highly critical health care service aiming prevention limb loss understanding nature complexity amputation scenario paramount effective preventive strategy planning implementation amputation incidence data trends show high variability international reports variability also remarkable granular regional comparison different calculation methods incidence fraction varying epidemiological demographic features populations different socio economic cultural backgrounds disparity vascular care arc main factors contributing variability reports lower limb amputations considered valuable healthcare quality indicator limitations one limitations lower actionability corresponds reduced ability health care providers intervene influencing burden amputations lower limb vascular amputations represent lifetime risk therefore effective revascularization achieved importance early recognition peripheral arterial disease delay referral special vascular care effective vascular risk prevention collaboration multidisciplinary teams also emphasized
traditional chinese medicines tcm proven prevent osteoporosis clinical applications widely recognized due complicated ingredients psoralidin prenylated coumestan reported prevent bone loss ovariectomized rats detailed mechanisms still clear current study found psoralidin coumestrol promoted osteoblast proliferation differentiation evidenced improvements cell proliferation alkaline phosphatase activity increased formation alp colonies calcified nodules enhanced secretion collagen bmp osteocalcin osteopontin stimulation expression igf beta catenin runx osterix opg well mrna ratio opg rankl significantly decreasing expression rankl addition psoralidin coumestrol inhibited osteoclast formation osteoclastic bone resorption demonstrated lower tartrate resistant acid phosphatase activity smaller area fewer resorption pits formed interestingly psoralidin showed much stronger effects coumestrol enhancing osteoblast proliferation differentiation inhibiting osteoclast differentiation bone resorption moreover found psoralidin coumestrol suppressed cox ros production rat osteoblastic calvarias cells psoralidin showed stronger effects coumestrol furthermore detected blocking estrogen receptors ici estrogen receptor antagonist osteoprotective effects psoralidin coumestrol also blocked findings demonstrated psoralidin coumestrol exert bone protective effects enhancing bone formation osteoblasts inhibiting bone resorption osteoclasts roles might mediated antioxidant activity transduced estrogen receptor signaling
study analyzed genome influenza virus wild birds virus identified novel reassortant virus internal genes multiple subtypes distinct origins sequential passage mice mouse adapted viruses bearing mutations generated viruses caused dramatic body weight loss death also replicated mouse brain suggesting pathogenicity low pathogenic chickens enhanced passage mammals data imply viruses might potential risk human health therefore important undertake continued surveillance biosecurity evaluation viruses
objective present study clarify features otological complications hyperbaric oxygen therapy hbot risk factors complications enrolled patients males females age years underwent hbot otological symptoms experienced hbot sessions evaluated risk factors analysed using multivariate logistic regression analysis otoscopic findings interventions otological complications assessed symptomatic patients visited otolaryngology department otological symptoms experienced patients multivariate logistic regression analysis identified ages years female sex independent risk factors whereas patients sports injuries lower risk primary diseases except severe infectious disease eighty two patients suffered symptoms first hbot session prevalent symptoms otalgia followed ear fullness hearing loss tinnitus one patient experienced vertigo deterioration bone conduction pure tone thresholds suggesting inner ear barotrauma ears symptomatic patients abnormal otoscopic findings recognized ears twenty seven ears required myringotomy tube insertion hbot stopped eight ears four patients remaining ears normal otoscopic findings received treatment physicians aware middle inner ear barotrauma potential complications hbot
background theory mind concerns sociocognitive ability infer others thoughts theorized impaired substance use abuse alterations might explain negative social interpersonal outcomes noted course disorders addition brain structures involved theory mind tom found disrupted drug use conditions objective undertook systematic review tom functioning drug use conditions methods four electronic databases medline web science psycinfo embase searched find studies addressed tom conditions related actual previous drug use results search found papers fulfilled review eligibility criteria different methods used overall results indicated drugs related tom deficits particularly related alcohol amphetamines use impairments correlate clinical cognitive functions conclusion despite lack studies methodological limitations existing ones theory mind seems play role drug use conditions requires investigation
proteomics pigs developing dynamically attracting much attention among representatives medical health sciences veterinary medicine agricultural natural sciences pig widely studied genetics genomics however proteomic applications still awaiting extensive implementation use pigs animal models biomedicine sciences exploration physiological tracts important pig production underdeveloped databases identification analysis porcine proteins well scarcity detailed information similarities differences humans pigs molecular level hampering pig proteomics however use pigs proteomic studies physiological biomedical sciences prevalent comparing farm animals focus reported pig model proteomics studies exploring physiology diseases improving pig breading productivity species used model proteomics studies involved ocular brain nutritional reproduction research etc present paper discuss technologies bioinformatic tools used studies proteome verify peptide protein based content summarize current status proteomic studies pigs focus studies female reproductive system examination understanding biology oocytes oviduct uterus could facilitate identification mechanisms involved prenatal development may help develop new treatment infertility farm animals
developed century ago steinmetz symbolic method still puzzling puzzles spite theoretical inconsistencies heuristically efficient however remains dominant method design analysis operation electrical power networks paper shows steinmetz mathematical expression electrical power based assumptions inconsistent algebra complex numbers paper argues although numbers correct mathematical interpretation numbers steinmetz got empirical right results wrong conceptual reasons success symbolic method based fact unwittingly steinmetz rediscovered grassmann clifford geometric algebra paper challenges dominant paradigm power theory represents voltage current active reactive apparent power complex numbers vectors phasors author proposes new paradigm entities represented algebraic group group composed scalar two vectors bivector residing four dimensional algebraic space two dimensional euclidean geometric space paper claims steinmetz symbolic method oldest engineering application clifford algebra paper provides strong motivation new didactic power theory based geometric algebra physics unifying language
development environment exerts profound influence wiring brain circuits due limited resolution studies fixed tissue experience dependent structural plasticity thought restricted specific developmental time window recent introduction two photon microscopy vivo imaging opened door repeated monitoring individual neurons study structural plasticity mechanisms fine scale review focus recent work showing synaptic structural rearrangements key mechanism mediating neural circuit adaptation behavioral plasticity adult brain examine work context classic studies visual systems model organisms laid much groundwork understanding activity dependent synaptic remodeling role brain plasticity
purpose study investigate prevalence gambling disorder comorbid psychiatric disorders homeless population identify features related potential subtypes baseline participants administered structured interview including socio demographic sections national comorbidity study ncs interview seven diagnostic sections diagnostic interview schedule dis alcohol drug abuse sections composite international diagnostic interview substance abuse module cidi sam homeless supplement dis nine months post baseline assessment participants administered additional ncs family history questions south oaks gambling screen sogs participants epidemiologic sample predominately african american homeless individuals grouped lifetime non gamblers recreational gamblers problem gamblers recruited street homeless shelters results indicate lifetime rates sub clinical problem disordered gambling significantly higher general population problem gamblers likely non problem gamblers meet diagnostic criteria antisocial personality disorder post traumatic stress disorder bipolar disorder psychiatric disorder likely non gamblers use illicit drugs meet criteria abuse dependence nicotine alcohol substance study provides evidence problem gambling significant public health issue among african american homeless population homeless services include assessment problem gambling along psychiatric disorders referrals resources treatment programs future studies explore relationship onset course problem gambling psychiatric disorders homelessness well racial differences gambling patterns problem severity time
background aim prosthetic cad cam systems require accurate limb models however difficulties arise working person socket since current scanners difficulties scanning socket interiors dedicated scanners exist expensive cost may prohibitive limited number scans per year low cost accessible photogrammetry method socket interior digitization proposed using smartphone camera cloud based photogrammetry services technique two dimensional images socket interior captured using smartphone camera model generated using cloud based software linear measurements comparing sockets related models discussion reconstruction accuracy averaged less accurate models obtained high quality scanners however method would provide viable digital socket reproduction accessible low cost processing prosthetic cad software
outstanding saharan dust event affected iberian peninsula winter february impact event ambient surface levels spatial temporal evolution investigated means data air quality stations across mainland spain balearic islands event significant impact surface levels february air quality monitoring sites registered concentrations daily limit value study attenuated backscattering vertical profiles associated african dust evidenced complex structure thick aerosol layer higher altitudes pre pyrenees compared coastal area barcelona closer surface typically observed sites optical physical properties dust particles investigated continental background global atmosphere watch mountain observatory montsec msa pre pyrenees good agreement found situ passive remote sensing methodologies aloft dust layer reached msa station scattering angstrom ngstrom exponent values decreased values close zero even zero surface situ measurements indicating predominance coarse particles contrary absorption angstrom ngstrom exponent values increased saharan dust outbreak denoting absorption enhancement shorter wavelengths characteristic mineral dust particles furthermore performance nmmb bsc dust bsc dreamb models qualitatively evaluated dust spatial distribution across spain vertical structure msa barcelona showing good agreement
undergoing concomitant chemotherapy radiation therapy anal cancer patients often experience significant side effects including grade radiation dermatitis pain exudate diarrhea case study presents grade reaction complicated complex medical conditions addition evidence based skin care treatment side effect management plan support patients intense period article offers creative strategies provide cost effective healing option
work methodology exp phi method given effectiveness method demonstrated applications two nonlinear partial differential equations npdes namely zakharov kuznetsov benjamin bona mahony bbm equation ill posed boussinesq equation obtained exact solutions consist trigonometric hyperbolic rational functions elsevier gmbh rights reserved
aim study examine gender differences various types childhood abuse family history crime substance abuse mental health problems study conducted among israeli female male inmates female male inmates findings indicated higher rate multiple types childhood abuse among female inmates compared male inmates findings also revealed female inmates reported prevalence parents substance abuse crime family mental health problems male inmates moreover female inmates reported higher rates emotional physical sexual abuse associated family history variables compared male inmates furthermore findings indicated female inmates whose siblings involved substance abuse crime reported higher rates sexual emotional abuse compared male inmates discussed implications findings
background parenting style associated children health related behaviors one popularity applicability assessment tools parenting style dimensions questionnaire psdq lack persian version seen study conducted determine validity reliability persian version psdq materials methods study done randomized cluster sampling parents cronbach alpha alpha coefficient used determine internal consistency pearson correlation coefficients used test retest reliability construct validity conformity factor analysis also applied determine construct validity results cronbach coefficient two authoritative authoritarian styles highest estimated value permissive style results correlation test three afore mentioned styles significant correlation coefficients authoritative style subscales authoritarian style subscales confirmatory factor analysis showed goodness fit indices including cmin gfi cfi ifi rmsea respectively indicated good construct validity instrument conclusion psdq translated persian obtained good reliability validity psdq questionnaire considered useful tool assessments interventions concerning parenting styles used iran
study propose upward leader leader exchange llx relationship important moderating condition predicting consequences leader member exchange lmx differentiation within work groups assert structural operating efficiencies created lmx differentiation depend group members appraisal legitimacy within group lmx disparity drawing relative deprivation theory argue level perceived legitimacy lmx differentiation varies levels llx using data collected subordinates managers work groups two time periods propose test hypotheses quality leader llx relationship moderate mediated relationship lmx differentiation group level teamwork team effectiveness find support moderated mediation model suggest implications theory practice
reported water energy nexus composes two biggest development human health challenges present study presented risk potential index rpi model encapsulates source vector transport target risks forecasting surface water contamination main aim model identify critical surface water risk zones open cast mining environment taking jharia coalfield india study area model also helps feasible sampling design based spatial analysis various risk zones successfully delineated monthly rpi distribution revealed risk surface water contamination highest monsoon months surface water samples analysed validate model gis based alternative management option proposed reduce surface water contamination risk observed decrease spatial distribution high risk areas months june july respectively elsevier ltd rights reserved
introduction inversion ankle sprain one common sports injuries often occurs final phase training competition although sprain multifactorial characteristic leads hypothesis muscle fatigue predisposing factor injury objective present study set investigate neuromuscular response fibularis brevis longus conditions fatigue methods study included physically active female participants history ankle sprain simulate inversion ankle sprain used simulation platform participant feet attached underneath right foot strap transducer induce fatigue first recorded maximal voluntary isometric contraction mvic eversion induction participants instructed maintain mvic strength fell mvic protocol interrupted participants immediately placed simulation platform fatigue conducted sprain simulations ankles randomly decided simultaneously electromyographic signal registered time domain latency signal amplitude analyzed results fatigue latency change however reduction signal amplitude drop amplitude considered response process fatigue decrease indicates reduction ability recruit motor units due changes neural input reaches muscle conclusion muscle fatigue reduces amplitude response eversion muscles ankle sprain
chapter first discusses unique properties phase change materials including structure amorphous crystalline phases well optical electrical scaling properties principles phase change memory pcm described including device characteristics cell concepts design advanced prototype devices scaling process integration include review materials engineering pcm shows materials optimized various pcm applications finally outlook given new applications phase change materials logic neuromorphic computing discussed
globally many politicians business leaders discussing best way transition towards green low carbon economy many countries involves reliance clean tech green entrepreneurs ecopreneurs implicated actors taking forward transition following case studies discuss emergence rhetoric around green economies green entrepreneurs considering couple real examples entrepreneurs running green businesses cases conclude questions thinking green entrepreneurs types businesses green entrepreneurs might run businesses encouraged operate green orientated philosophies
class electrochemical reactor hydrogen production developed using bipolar plates fabricate thick large area electrodes particle electrode fabrication method also introduced scanning electron microscopy energy dispersive ray spectroscopy galvanostatic performance measurements performed evaluate particle electrodes results show particle electrodes exhibit excellent charge performance despite electrode material layer relatively thick highly porous electrochemical reactor contained single cells stacked together nickel hydroxide metal hydride positive negative electrodes respectively electrochemical tests showed stack exhibited high hydrogen production efficiency maximum current efficiency hydrogen production hydrogen evolution amount per unit input electrical energy high current densities rapid temperature increase also observed charging process led reduction hydrogen production efficiency therefore design modifications needed control heat generation operation device published elsevier ltd
considerable heterogeneity observed among patients borderline personality disorder bpd present study investigated whether could identify validate different personality subtypes bpd inpatients based reactive regulative temperament identified four bpd subtypes means cluster analysis behavioral inhibition behavioral activation scales bisbas effortful control scale ecs emotional disinhibited subtype scoring lowest effortful control inhibited subtype characterized bylaw levels behavioral activation low anxiety subtype defined low levels behavioral inhibition high self control subtype characterized highest score effortful control four subtypes validated comparing clinical symptomatology comorbid personality disorders coping current findings offer insight meaningful differences among bpd patients based temperamental features offer guidelines treatment bpd patients elsevier ltd rights reserved
investigate impact novel method called virtual mirroring promote employee self reflection impact customer satisfaction method based measuring communication patterns social network semantic analysis mirroring back individual goal demonstrate self reflection trigger change communication behaviors lead increased customer satisfaction illustrate test approach analyzing mails large global services company comparing changes customer satisfaction associated team leaders exposed virtual mirroring experimental group find increase customer satisfaction experimental group decrease control group team leaders involved virtual mirroring process regard individual communication indicators find customer satisfaction higher employees responsive use simpler language embedded less centralized communication networks show stable leadership patterns elsevier inc rights reserved
paper recent research trends activities structural health monitoring shm civil infrastructure korea reviewed recently increasing need adopting smart sensing technologies shm review focuses smart sensing monitoring assessment civil infrastructure firstly research activities smart sensor technology reviewed including optical fiber sensors piezoelectric sensors wireless smart sensors vision based sensing system brief overview given recent advances smart monitoring assessment techniques vibration based global monitoring techniques local monitoring piezoelectric materials decentralized monitoring techniques wireless sensors wireless power supply energy harvest finally recent joint shm activities several test beds korea discussed share date information promote smart sensors monitoring technologies applications civil infrastructure includes korea joint research test bridges korea expressway corporation kec korea japan joint research jindo cable stayed bridge comparative study cable tension measurement techniques hwamyung cable stayed bridge campaign test displacement measurement techniques sorok suspension bridge
many mathematical models physical phenomenons engineering fields electrical circuits mechanical multibody systems generate differential algebraic equations daes systems naturally general feature daes sparse large scale system fully nonlinear high index make use sparsity paper provides simple efficient algorithm index reduction large scale daes system exploit shortest augmenting path algorithm finding maximum value transversal mvt well block triangular forms btfs also present extended signature matrix method block fixed point iteration complexity results furthermore range nontrivial problems demonstrated algorithm elsevier inc rights reserved
paper presents novel control scheme based auto tuning pid controller suppress wing rock phenomena due complex dynamic wing rock motion identification simple task complexity adversely affect performance pid controller employing wavelet neural network based identifier paper develops auto tuning adaptive pid controller tackle problem since acceptable control performance inevitably involves meticulously trained identifier training performance utmost importance aiming boosting training efficacy two phase algorithm encompassing bees algorithm back propagation proposed paper train proposed identifier respectively line line modes due inherent capability sifting global minima bees algorithm employed find initial values weights around possible conduct local search means based online training therefore identifier precisely furnish proposed pid controller system sensitivity line mode adaption pid controller thus performed time step performance method presented simulation results comparison section confirms effectiveness proposed scheme
background various studies shown non communicable diseases ncds especially diabetes hypertension prevalent among older women living south african urban areas placing heavy burden healthcare system study aimed understand health seeking behaviour healthcare practices prevalence traditional herbal medicine thm use among older women self reporting ncds prospective urban rural epidemiology study pure method homogenous purposive sampling pure participants used recruit women years older descriptive statistics used examine number ncds reported study sample health seeking behaviour practices well thm use logistic regression also employed investigate possible associations reported conditions thm use medical pluralism results within study sample self reported ncd self reported ncds one two ncds ncds usually visited public clinics relied doctors nurses health information mostly used conventional medicine manage high blood pressure ncds indicated using thm reported practicing medical pluralism participants dental problems headaches heart burn severe tiredness likely use thm anxiety allergies increased likelihood practise medical pluralism five times respectively conclusion self reported ncd morbidities prevalent among participants study study participants utilized state owned clinics hospitals management chronic conditions thm use common however among used thm medical pluralism prevalent family history common reason thm use many thm patrons utilizing treatment health condition older black women anxiety allergies likely practise medical pluralism
little known association vitamin deficiency skeletal phenotypes primary hyperparathyroidism phpt patients low hydroxyvitamin level associated low bone mineral density deteriorated hip geometry women phpt asian population vitamin deficiency prevalent studies examined effect vitamin deficiency bone health primary hyperparathyroidism phpt patients investigated skeletal effects vitamin deficiency phpt patients assessing bone mineral density bmd trabecular bone score tbs hip geometry measured using dual energy ray absorptiometry men median age years postmenopausal women median age years cross sectional data collected subjects enrolled ongoing phpt cohort study seoul national university hospital march december classified phpt patients according hydroxyvitamin levels adjusting age body mass index women vitamin deficiency lower bmds lumbar spine femur neck women sufficient levels vitamin however total hip bmd tbs significantly different two groups hip geometry analysis cross sectional area cross sectional moment inertia section modulus also significantly lower women vitamin deficiency without significant difference found bmd tbs hip geometry according levels men vitamin deficiency may associated low bmd deteriorated hip geometry postmenopausal women phpt
present analogue signal processing circuit suitable applications portable wearable non invasive electrooculogram based human computer interface behavioural model preliminary experimental results confirm proposed circuit operating real time correctly detects decodes signals generated subject eye movements total power consumption measured excluding link power supply voltage unit size approximately printed circuit board copyright john wiley sons ltd
introduction despite existence published guidelines decade still substantial variation management idiopathic normal pressure hydrocephalus due diagnostic therapeutic complexity development diagnostic therapeutic protocol management idiopathic normal pressure hydrocephalus use department neurosurgery university hospital marques valdecilla presented diagnostic process includes neuropsychological testing phase contrast cine mri urodynamic evaluation continuous intracranial pressure monitoring cerebrospinal fluid hydrodynamics means lumbar infusion testing intra abdominal pressure measurement patient considered surgical candidate following criteria met mean intracranial pressure mmhg waves present overnight recording pressure volume index mmhg min bolus infusion test mmhg min intracranial pressure mmhg high amplitude waves steady state continuous rate infusion test clinical response high volume cerebrospinal fluid withdrawal conclusions implementation diagnostic therapeutic protocol idiopathic normal pressure hydrocephalus management could improve various aspects patient care could reduce variability clinical practice optimise use health resources help identifying scientific uncertainty areas order direct research efforts appropriate way sociedad espanola neurocirugia published elsevier espana rights reserved
optimal management large environmental systems often limited high computational burden associated process based models commonly adopted describe systems paper propose novel data driven dynamic emulation modelling approach construction small computationally efficient models accurately emulate main dynamics original process based model less computational requirements approach combines many advantages data based modelling representing complex non linear relationships preserves state space representation particularly effective several applications optimal management data assimilation facilitates post physical interpretation emulator structure thus enhancing credibility model stakeholders decision makers core mechanism novel variable selection procedure recursively applied data set input state output variables generated via simulation process based model approach demonstrated real world case study concerning optimal operation selective withdrawal reservoir tono dam japan suffering downstream water quality problems emulator identified data set generated coupled hydrodynamic ecological model subsequently used design optimal operating policy dam preliminary results show proposed approach significantly simplifies learning good operating policies highlight interesting properties system controlled elsevier ltd rights reserved
new type smart material namely magneto thixotropic gel proposed study investigate rheological behaviour experiment designed predict interaction among shear strain rate shear stress magnetic induction viscosity theoretical analysis interactive processing testing data compared magneto rheological fluids experimental results indicate magneto thixotropic gel possesses better linear magnetization property higher shear yield stress shear strain rate changes shear stress keeps relatively stable trend exposed certain magnetic field meanwhile computational viscosity rise decrease shear strain rate increasing magnetic induction keeps linearly increase increasing magnetic induction shear strain rate
goal current study improve understanding adolescence critical period consideration declining mental health focusing impact homophobic name calling early adolescent mental health transition middle school know homophobic name calling emerges within dynamic peer group structure used longitudinal social network analysis assess relation homophobic name calling depressive symptoms self esteem simultaneously limiting bias alternative peer socialization mechanisms sample adolescents recently transitioned large public middle school girls age years assessed longitudinal assessments peer relationship networks depressive symptoms self esteem collected fall spring academic year results suggest accounting simultaneous effect alternative peer socialization processes adolescent experiences homophobic name calling fall predict higher levels depressive symptoms lower levels self esteem course academic year findings provide evidence significant influence homophobic name calling adolescent mental health
link experiences care criminal justice systems well documented yet curiously neglected policy practice representation care leavers justice system often taken given negligible change policy practice appropriately responds needs individuals drawing interviews practitioners article highlights series organizational institutional barriers implementing unique intervention broadly barriers contribute persistence care less practice facilitating neglect care leavers needs system dominated risk argued continued inertia within area construed practice negligence affront justice
bioelectrochemical systems bess may used upgrade anaerobic digester biogas directly converting objective study evaluate gas carbon transport within methanogenic bes four bes configurations evaluated abiotic anode abiotic cathode aan aca bioanode abiotic cathode ban aca abiotic anode biocathode aan bca bioanode biocathode ban bca transport gas commonly used flushing anoxic systems anode headspace ranged atm normalized proton exchange membrane pem surface area net driving pressure ndp transported cathode anode headspace rates atm flux cathode anode headspace greater system biocathode aan bca produced abiotic cathode ban aca even though abiotic cathode headspace aan bca biocathode end day day carbon balance batch fed ban bca bes showed transient microbial carbon storage net transport carbon anode cathode day batch incubation production biocathode greater molar basis initial supplied biocathode headspace indicating conversion produced anode research expands current understanding methanogenic bes operation may used improving assessment bes performance development alternative bes designs mathematical models biotechnol bioeng wiley periodicals inc
mild traumatic brain injury mtbi affects large number individuals diffusion tensor imaging used investigate microstructural integrity brain tissue mtbi however results varied considerably studies gray matter integrity largely neglected investigations given impaired working memory processing mtbi possible association alzheimer disease investigated hippocampal integrity parcellated structure five subregions subiculum cornu ammonis dentate gyrus stratum radiatum lacunosum moleculare also employed shape analysis bilateral hippocampi explore whether morphological changes occurred due traumatic injury conducted neuropsychological memory tests sample comprised subjects mtbi years nine female age sex matched healthy control subjects years nine female voxelwise analyses showed significantly increased mean diffusivity patients compared controls right hippocampus three five subregions family wise error corrected additionally results probabilistic tractography indicated impaired connectivity mtbi benjamini hochberg false discovery rate fdr corrected subjects mtbi reported symptoms performed worse non standard verbal working memory task based preliminary findings able demonstrate altered diffusivity hippocampal subregions following mtbi indicating impaired microstructural integrity differences highlight potential diffusion imaging investigation subtle yet relevant changes microstructure detected otherwise following mtbi
largely due colonial past neocolonial present filipinos receiving certain messages generations regarding heritage western culture facing constant tensions struggles filipino western individual collective constant push pull filipino western cultural values shape reflected filipinos daily lives interactions interactions rest world end article discusses wide range factors pertinent filipino americans immigration family structure values parenting gender roles intergenerational issues convey factors need understood context colonialism legacies contemporary implications conceptualizing filipinos americans experiences also provide discussion filipino values beyond surface talk core filipino value kapwa ethnic identity acculturation cultural conflicts among filipinos need conceptualized kapwa discuss colonialism insidious legacy colonial mentality may influence kapwa acculturation ethnic identity filipino american families end recommendations researchers service providers hope historically informed sociopolitically contextualized understanding filipino americans helpful work population
usually difficult compute principal curvatures smooth surface sufficient differentiability rather difficult task polygonal approximation surface available inherent ambiguity representation number different approaches proposed past tackle problem using various techniques papers tend focus particular method comprehensive comparison different approaches usually missing present results large experiment involving common recently proposed curvature estimation techniques applied triangle meshes varying properties turns none approaches provides reliable results circumstances motivated observation investigate mesh statistics computed vertex positions mesh connectivity information help deciding estimator work best particular case finally propose meta estimator makes choice existing algorithms based value mesh statistics demonstrate meta estimator despite simplicity provides considerably robust results existing approach
mendelian randomization uses genetic data probe questions causality epidemiological research invoking instrumental variable assumptions recent years become commonplace attempt analyses synthesising summary data estimates genetic association gleaned large independent study populations referred two sample summary data unfortunately due sheer number variants easily included summary data analyses increasingly likely meet assumptions due pleiotropy pressing need develop methods detect correct pleiotropy order preserve validity approach context paper aim clarify established methods meta regression random effects modelling mainstream meta analysis adapted perform task specifically focus two contrasting approaches inverse variance weighted ivw method assumes simplest form genetic variants valid ivs method egger regression allows variants violate assumptions albeit specific way investigate ability two popular random effects models provide robustness pleiotropy ivw approach propose statistics quantify relative goodness fit ivw approach egger regression authors statistics medicine published john wiley sons ltd
recent advances neuroscience given unprecedented insight neural mechanisms false memory showing artificial memories inserted memory cells hippocampus way indistinguishable true memories however alone enough explain false memories arise naturally course daily lives cognitive psychology demonstrated many instances false memory laboratory real world attributed semantic interference whereas previous studies found diverse set regions show involvement semantic false memory none revealed nature semantic representations underpinning phenomenon use fmri representational similarity analysis search neural code consistent semantic false memory find clear evidence false memories emerge similarity based neural code temporal pole region called semantic hub brain show individual partially unique semantic code within temporal pole unique code predict idiosyncratic patterns memory errors finally show neural code also predict variation true memory performance consistent adaptive perspective false memory taken together findings reveal underlying structure neural representations semantic knowledge semantic structure enhance distort memories
atopic dermatitis allergic urticaria common conditions skin also presenting symptoms uncommon diseases defects leading immunodeficiency may associated atopic dermatitis allergic urticaria unusually severe otherwise atypical presentations atopic dermatitis allergic urticaria may lead clinical suspicion underlying immunodeficiency
backgroundplaygroups relatively unique form family support programme common australia high community acceptance significant government investment however limited evidence exists regarding effectiveness playgroups achieve better outcomes children parents study describes patterns playgroup participation aboriginal torres strait islander families young children examines extent participation birth three years associated subsequent child parent community outcomes methodsthis study uses three years longitudinal data aboriginal torres strait islander children participants longitudinal study indigenous children lsic longitudinal associations playgroup attendance children age years outcome measures child vocabulary motor skills behaviour problems prosocial development parent home learning engagement resilience advice seeking health service use community trustworthiness examined using path analysis resultsrates playgroup participation sample group generally lower australian children overall playgroup attendance children age years associated higher parental engagement home learning activities children aged years turn associated stronger expressive vocabulary scores children conclusionthe findings study suggest playgroup participation enhance home learning environments aboriginal torres strait islander children playgroups parent support programme hold strong potential reach engage families particularly areas high geographic isolation realize improved outcomes children parents communities
paper developed new kind ionic polymer metal composite ipmc actuator doping water soluble sulfonated multi walled carbon nanotube smwcnt nafion matrix overcome major drawbacks traditional ipmcs relatively low bending deformation carring capacity low driving voltages firstly smwcnt synthesized via diazotization coupling reaction doped nafion matrix casting method subsequently electrochemical electromechanical properties smwcnt reinforced nafion membranes corresponding ipmcs investigated finally effects smwcnt performances ipmcs evaluated analyzed systematacially results showed smwcnt homogeneously dispersed nafion matrix without entangled structure obvious agglomeration main factors superior actuation performances like water uptake ratio proton conductivity elastic modulus increased significantly compared pure nafion ipmc mwcnt nafion ipmc much superior electrochemical electromechanical performances achieved smwcnt nafion ipmc attributed numerous insertion sites high surface conductivity excellent mechanical strength well homogeneous dispersity incorporated smwcnt herein trace amount smwcnt improve performances ipmcs significantly realistic applications
suboptimal weight loss swl weight regain gastric bypass surgery remains poorly understood study aims compare patients experiencing swl significant sigwr successful controls regarding postoperative food intake eating behavior physical activity psychometrics forty nine patients year post surgery classified either experiencing swl excess body weight loss ewl sigwr total weight regain respective control groups energy intake measured food frequency questionnaire eating behavior using dutch eating behavior questionnaire three factor eating questionnaire using sensewear armbands international physical activity questionnaire eating disorders depression quality life qol measured using eating disorder examination questionnaire beck depression inventory impact weight quality life respectively macronutrient distribution meal frequency similar among groups however disinhibited eating behavior score higher subcategories iwqol significantly lower swl sigwr groups compared respective controls significantly lower swl sigwr groups compared respective controls differences groups regarding depression lower levels disordered eating behavior lower qol associated unsuccessful weigh loss outcome surgery longitudinal studies needed clarify potential causal relationship previously described variables swl sigwr
aim study assess indirect costs health related quality life clinical characteristics patients psoriatic arthritis psa measured using psa disease activity index poland additionally aimed investigate association activity utility psa affected patients productivity loss polish setting questionnaire survey conducted assess disease activity well productivity loss paper version euroqoly questionnaire used assess productivity loss quality life indirect costs assessed human capital approach employing gross domestic product gdp per capita gross value added gva gross income per worker poland expressed polish zlotys pln well euros correlation presented using spearman correlation coefficient analysis performed basis full questionnaires collected observed mean utility value mean number days work days per month mean job productivity loss average monthly indirect costs per patient sic pln calculated using gdp sic pln calculated using gva sic pln calculated using psa reduces patients quality life well productivity loss associated absenteeism presenteeism total indirect costs negatively correlated utility greater disease activity lower utility greater indirect costs
success rituximab treatment active graves orbitopathy suggests cells play critical role intraorbital inflammation cell activating factor baff homolog proliferation inducing ligand april critical cell survival however contribution baff april remains unclear sought determine role baff april orbits found baff markedly upregulated april additionally cultured orbital fibroblasts ofs expressing baff induced produce large amount baff contrast weak april expression detected ofs exhibited slight response stimulation notably pretreated ofs promoted cell survival effect significantly inhibited baff neutralizing antibody study indicates ofs express baff mediate intraorbital survival cells via baff mechanism elsevier rights reserved
study proposes novel approach evaluating controlling traction force wheel directly driven electric motor different road surfaces instead slip ratio measurements database motor called current rpm torque database evaluate traction force wheel feedback measured current rotational speed assist autonomous traction controller synthesized database neural network approach one traction wheel vehicle traveling different kinds road surfaces adequate gains training data neural network control synthesis satisfy assigned specifications time domain different slip ratios paper also finds adequate gains mainly depend slip ratio slope rather slip ratio based scenario similar real situations simulated results study show feasible evaluate control traction force motor database feedback current rpm
background numerous previous studies reported human health risk extremely sensitive temperature studies however characterized relationship temperature mortality different temperature zones due previous conclusions deduced regional administrative division research covers different temperature zones indispensable comprehensive understanding regional ambient temperature effect public health methods based mortality dataset meteorological variables communities china distributed lag nonlinear model dlnm utilized estimate temperature effect non accidental mortality community level meta regression analysis applied pool estimates community specific effects various latitude effected temperature zones results community level mean value relative extreme cold risk communities higher extreme high temperature regional level found temperature mortality relationship shaped varied different temperature zones meanwhile minimum mortality temperature zone near percentile local mean temperature except north subtropics percentiles lag effect also obvious especially cold effect interesting shaped curve relationship cold risk temperature detected inverted shaped right tail heat effect different responses might attributed difference social economic status temperature zones conclusion temperature mortality relationship showed distinct spatial heterogeneity along temperature zones across chinese mainland different characteristics mortality responding cold heat stress highlighted fact apart circumstance temperature social economic condition also linked health risk findings suggest decision makers take adaptive effective measures reduce health risks china elsevier rights reserved
objective efficient treatments phase advance human circadian rhythms needed attenuate circadian misalignment associated negative health outcomes accompany early morning shift work early school start times jet lag delayed sleep phase disorder study compared three morning bright light exposure patterns single light box mimic home treatment combination afternoon melatonin methods fifty adults males aged years participated sleep dark advanced day three treatment days participants took melatonin baseline bedtime treatment day hour earlier treatment day exposed one three bright light similar lux patterns upon waking morning four min exposures separated min room light group four min exposures separated min room light group one min exposure group dim light melatonin onsets dlmos treatment determined phase advance results compared group phase shift smaller phase advance shifts seen groups pattern produced largest phase advance however single min bright light exposure effective bright light spread produced phase shift observed bright light conclusions min morning bright light exposure afternoon melatonin efficient treatment phase advance human circadian rhythms elsevier rights reserved
four individual dugongs dugong dugong muller tracked buoyant tethered conventional satellite radio transmitters dugongs three adult females one immature male encircled net catch site near haruku island east indonesia tracked days animals showed individualistic patterns movement moving core areas travelling site capture one adult female spent time two distinct inshore seagrass beds separated made five trips two sites two females made separate trips two distinct sites one returning catch site haruku island immature male journeyed two areas apart completing journey four days patterns movement confirmed practice regular recropping restricted grazing swards small loose feeding assemblages rather fixed herds strong social bond mean home ranges covered harmonic mean harmonic mean
prototyping evaluation imperative phases present product design development process although digital modeling analysis methods widely employed various product development stages still building physical prototype makes present typical process expensive time consuming therefore necessary implement new technologies virtual prototyping enable industry rapid controlled decision making process virtual prototyping come long way recent years current environments enable stereoscopic visuals surround sound ample interaction generated models also important evaluate representative developed virtual prototype compared real world counterpart sense presence reported users virtual prototype paper describes systematic procedure develop virtual prototype gazal first car prototype designed saudi engineers semi immersive virtual environment steps develop virtual prototype cad computer aided design models explained detail various issues involved different phases development virtual prototype also discussed comprehensively paper describes results subjective assessment developed virtual prototype saudi arabian designed automobile user feedback recorded using presence questionnaire based user based study revealed virtual prototype representative real saudi arabian car offers flexible environment analyze design features compared physical prototype capabilities virtual environment validated application car prototype finally vital requirements directions future research also presented
benefits cloud computing include reduced costs high reliability immediate availability additional computing resources needed despite advantages cloud service provider csp consumers need aware clouds poses set unique risks typically associated storing processing one data internally using privately owned infrastructure new techniques searchable encryption deployed enable data encrypted online despite relatively obscure form cryptography searchable encryption point deployed used within cloud searchable encryption allow csp customers store data encrypted form retaining ability search data without disclosing associated decryption key csps searchable encryption diverse subject exists many forms searchable symmetric encryption sse roots plaintext searching one form although symmetrically encrypted ciphertext searched manner nonetheless many principles apply plaintext searching also apply sse basic form sse nothing inverted indexa mechanism used plaintext information retrieval decadesthat modified adapted use ciphertext implement sse scheme evaluate efficiency storing retrieving data cloud results showed carrying task using sse directly proportional amount information involved case constructing inverted index results show time taken generate inverted index directly proportional number terms contained underlying document collection converting inverted index sse inverted index directly proportional number postings contained within inverted index time taken encrypt underlying document collection directly proportional number terms contained within document collection relation searching sse time taken identify decrypt set postings associated given lexicon term directly proportional number postings believe sse efficient enough deployed cloud environment especially results returned user small quantities applied large sets sse querying become inefficient search time directly proportional number matching sse however designed achieve efficient search speeds whilst maintaining data privacy copyright john wiley sons ltd
real time adaptive optics technology enhancing resolution ground based optical telescopes overcoming disturbance atmospheric turbulence performance system limited delay errors induced servo system photoelectrons noise wavefront sensor order cut delay errors paper proposes novel model forecast future control voltages formable mirror predictive model constructed multi layered back propagation network bayesian regularization brbp purpose parallel computation less disturbance adopt number sub neural networks substitute whole network bayesian regularized network assigns probability network weights allowing network automatically optimally penalize excessively complex models simulation results show brbp introduces smaller mean absolute percentage error mape mean square errors mse typical algorithms meanwhile real data analysis results show brbp model strong generalization capability parallelism elsevier rights reserved
aim study assess water pollution terms total content heavy metals parameter called heavy metal pollution index hpi water samples collected four different locations along course river spring autumn seasons concentrations lead cadmium iron zinc manganese copper arsenic mercury determined using atomic absorption spectroscopy data used evaluate hpi river water mean value hpi spring season autumn season average seasons sampling sites maximum value found one sampling site critical index limit also values mean hpi sampling site could concluded pollution load sampling site significant hpi
polyhedral mesh generation standard tessellation language stl models presented scaled boundary finite element method sbfem stl format widely used printing computer aided design cad systems describe surface geometry object stl model visualisation usually flaws incompatible mesh generators developed finite element method fem found abaqus ansys etc paper combine octreebased polyhedral mesh generation sbfem perform automatic stress analyses stl models sbfem capability model arbitrary polyhedron discretising boundary mesh generation effort significantly reduced basic idea proposed method first creating octree grid encloses stl model trimming grid stl surface trimming process follows bottom scheme starting edges faces cells within framework recovery method sharp features also developed reconstruct hard edges points required explicitly represented mesh numerical examples presented demonstrate effectiveness versatility proposed approach elsevier rights reserved
emerging use multi homed wireless devices along simultaneous multi path data transfer offers tremendous potentials improve capacity multi hop wireless networks use simultaneous data transfer separate disjoint paths multi hop wireless networks increase network capacity less explored subject mainly challenges triggers reliable transport layer protocols reliable transport layer protocols generally use packet sequence number mean ensure delivery order packet arrival reliable transport layer protocols triggers receiver buffer blocking causes throughput degradation prevents reliable multi path transport layer protocol realize vast potential paper focuses integrating network coding reliable multi path transport layer protocol resolve receiver buffer blocking problem propose adaptive network coding mechanism desensitize receiver packet reordering consequently eliminate receiver buffer blocking problem state art network coding scheme uses combination learning logistic regression rare data events control number redundant packets based network dynamics confirmed veracity proposed scheme queuing theory based mathematical model moreover effectiveness proposed scheme demonstrated simulations testbed experiments
paper concerns problem dynamic modelling parameter estimation seven degree freedom hydraulic manipulator laboratory example dual manipulator mobile robotic platform used research nuclear decommissioning contrast earlier control model orientated research using machine paper develops nonlinear mechanistic simulation model subsequently used investigate physically meaningful disturbances second contribution optimise parameters new model determine reliable estimates physical parameters complex robotic arm known advance address nonlinear non convex nature problem research relies multi objectivisation output error single performance index developed algorithm utilises multi objective genetic algorithm order find proper solution performance model evaluated using simulated known set true parameters experimental data simulation experimental results show multi objectivisation improved convergence estimated parameters compared single objective output error problem formulation achieved integrating validation phase inside algorithm implicitly exploiting inherent structure multi objective specific system identification problem
objectives evaluate volumetric bmd vbmd microarchitecture strength vertebral fractures vfs primary pss methods evaluated female pss patients gender age race matched controls clinical data including risk factors osteoporosis fractures collected standardized protocol areal bmd vfs analysed dxa bone microarchitecture vbmd bone strength assessed high resolution peripheral quantitative pqct non invasive method results pss patients controls comparable age bmi calcium intake smoking menopause sedentary lifestyle family history fractures low bmd patient age vfs frequent patients controls pqct showed deterioration cortical trabecular components strength radius cortical components strength tibia patients compared controls pss patients controls also analysed multivariate analysis adjusted age ethnicity prednisone use weight height showed pss group lower values cortical vbmd cortical thickness apparent modulus radius cortical vbmd apparent modulus tibia patients vfs cortical bone deterioration cortical vbmd cortical thickness tibia compared patients without vfs conclusions study first assess bone microarchitecture pss demonstrated cortical deterioration important abnormality observed pss patients vfs novel finding shows compartment contributes vertebral fragility suggesting non invasive evaluation may useful clinical practice
green roofs proposed way mitigate stormwater run urban areas due possibility retrofit existing buildings amount run influenced humidity evapotranspiration well soil type depth modelling approach undertaken evaluate response different soil depths cumulative rainfall efficiency stormwater flow rate attenuation soil hydraulics modelled using hydrus software developed modelling water flow variably saturated porous media model runs carried three quarterly scenarios determine run peak flow rates overall retention based evapotranspiration rates succulent plants rainfall registers auckland new zealand soil depths modelled ranged efficiencies peak flow attenuation shallowest soil considered reduced extreme longer rainfall events therefore shallow soil extensive green roofs may wide scale overcome performance deep soils due lighter weight adds limited loads existing roof structures thereby making suited retrofit greater numbers buildings elsevier rights reserved
airlift reactors numerous applications processing industries thus hydrodynamic behaviors using fluids distinct rheological characteristics need better understood successful design operation devices sense novelty study evaluate influence energy losses reactor region interstitial liquid velocity provide correlations prediction gas hold ups epsilon epsilon wide range physical rheological properties liquid using different models draft tube dta split cylinder sca scales airlift reactors gas hold ups determined manometric method calculated circulation time spheres liquid density energy losses calculated using semi theoretical method total energy dissipated riser downcomer greater dta reactors whereas bottom greater sca reactors non newtonian fluids showed higher vlr sca reactors opposite observed newtonian fluids excellent fits experimental data achieved using simple correlations predict epsilon epsilon well dimensionless correlations incorporated desired parameter elsevier rights reserved
background health service providers restrict access contraceptives imposed biases method appropriateness study provider biases toward contraceptive service provision among urban nigerian providers assessed methods health providers working health facilities well pharmacists patent medical vendors pmv abuja benin city ibadan ilorin kaduna zaria surveyed concerning self reported biases service provision based age parity marital status results minimum age bias common bias minimum parity least common bias reported providers condoms consistently provided least amount bias followed provision emergency contraception pills injectables iuds experience service training health facility providers associated decreased prevalence marital status bias pill injectable iud however training experience opposite effect pharmacists pmv operator reports service provision bias conclusions provider imposed eligibility barriers urban study sites nigeria pervasive prevalent restriction across method provider type minimum age given large growing adolescent population interventions aimed increasing supportive provision contraceptives youth context urgently needed results show effect service training provider biases limited future efforts address provider biases contraceptive service provision among provider types must find creative ways address critical barrier increased contraceptive use
chapter control design approach based linear parameter varying lpv systems exploited solve several problems typically encountered control engineering presented means recent techniques based youla kucera parametrization shown possible design optimize stabilizing controllers also exploit structure youla kucera parametrized controller face solve side problems including dealing nonlinearities taking account control input constraints performing controller commutation online adaptation presence faults dealing delays system control scheme observer based namely prestabilizing observer based precompensator applied consequently youla kucera parameter applied produce supplementary input ignition function residual value difference output estimated output based fact stable operator maps residual supplementary input preserves stability several additional features added compensator without compromising loop stability
battery energy storage systems besss increasingly installed power system especially growing penetration rate renewable energy sources however difficult besss profitable due high capital costs order boost economic value besss paper proposes hierarchical energy management system hiems aggregate multiple besss achieve multimarket business operations proposed hiems optimizes multimarket bids considering realistic bess performance model coordinates besss manages state charge values according price penalties based dynamically generated annualized cost taking part energy market regulation market time cost performance index cpi bess aggregation greatly improved impact photovoltaic generation system performance cpi also studied
background rotator cuff lesions one major causes shoulder pain dysfunction numerous non surgical treatment modalities described chronic rotator cuff lesions debate continues optimal procedure aim report present results prolotherapy treatment chronic refractory rotator cuff lesions hypothesis dextrose prolotherapy reduce pain improve shoulder function patient satisfaction material methods recruited patients chronic rotator cuff lesions symptoms persisted longer months patients divided two groups one treated exercise control group treated prolotherapy injection prolotherapy group latter ultrasound guided prolotherapy injections applied aseptic conditions former patients received physiotherapy protocol three sessions weekly weeks groups instructed carry home exercise program clinical assessment shoulder function performed using visual analog scale vas pain shoulder pain disability index spadi western ontario rotatory cuff worc index patient satisfaction shoulder range motion patients examined baseline weeks last follow minimum one year results total patients controls prolotherapy group completed study protocols included study using within group comparison groups achieved significant improvements baseline measured vas spadi worc index shoulder range motion using group comparison significant difference found vas scores baseline weeks last follow addition significant differences found spadis worc indices weeks last follow significant differences found shoulder abduction flexion week last follow internal rotation last followup however significant found external rotation follow period prolotherapy group patients reported excellent good outcomes control group patients reported excellent good outcomes conclusion prolotherapy easily applicable satisfying auxiliary method treatment chronic rotatory cuff lesions study type randomized prospective comparative trial elsevier masson sas rights reserved
violence video games come increasing research attention past decade researchers area suggested violent video games may cause aggressive behavior among players however state extant literature yet examined publication bias current meta analysis designed correct oversight results indicated publication bias exist experimental studies aggressive behavior well non experimental studies aggressive behavior aggressive thoughts research areas including prosocial behavior experimental studies aggressive thoughts less susceptible publication bias moderator effects results also suggested studies employing less standardized reliable measures aggression tended produce larger effect sizes suggestions future violent video game studies provided elsevier ltd rights reserved
skin associated chemokine ccl receptor ccr mediate immune response skin homing cells ccl secreted keratinocytes reportedly involved inflammatory skin diseases atopic dermatitis contact dermatitis psoriasis however whether ionizing radiation increases levels ccl secretion still remains unclear hacat cells human keratinocyte cell line ccl secretion markedly increased ray irradiation found irradiation boosted generation reactive oxygen species ros concomitant release tumor necrosis factor alpha tnf alpha moreover alteration ros irradiated hacat cells correlated tnf alpha secretion indicating positive loop tnf alpha secretion ros generation positive loop regulated secretion ccl irradiated cells therefore concluded cross talk tnf alpha ros keratinocytes exposed radiation triggered ccl secretion subsequent inflammation response
concept soil line describe temporal distribution spectral characteristics bare soil surface case soil line referred multi temporal soil line simply temporal soil line tsl order create tsl regular lattice points territory three regions tula oblast used landsat images obtained period certain transformation landsat images matrices values spectral brightness transformation normalization matrices several methods normalization move rotate scale spectral plane study applied method piecewise linear approximation spectral neighborhood soil line order assess quality normalization mathematically approach allowed range normalization methods according quality follows classic normalization successive application turn shift successive application atmospheric correction shift atmospheric correction shift turn raw data normalized data allowed create maps distribution coefficients tsl map coefficient characterized high correlation ground truth data obtained soil pits described soil surveys performed local institute land management giprozem
paper propose secured openflowbased switch architecture architecture combination openflow processing routes packets according openflow protocol security processing defends network attacks therefore proposed switch work openflow based forwarding device also network protection system implement prototype switch xilinx virtex xcvtxt fpga device prototype version integrate two different ddos countermeasure techniques hop count filtering port ingress egress filtering experimental results show switch achieves packet processing throughput gbps ddos detection rate false positive rate false negative rate obtained prototype system uses look tables registers block ram fpga device
united states access emergency contraceptive pills ecps expanded nationwide regulators allowed plan brand emergency contraception sold without prescription using data national health nutrition examination survey examined association increased access ecps negative consequences found association increased access ecps per cent higher probability sexual activity per cent increase likelihood reporting sex multiple partners increase average number partners per cent decrease likelihood injectable contraceptive use results suggest policies countries expand access ecps paired information ecps lack protection sexually transmitted infections relatively lower efficacy compared forms contraception
aimto calculate epidemiology rheumatic diseases iran materials methodsthe data tehran zahedan sanandaj urban tuyserkan rural stage community oriented program control rheumatic diseases copcord studies gathered data adjusted population number studied areas represent iran resultsthe population iran urban areas males mentioned area respectively interviewed subjects male female ratio musculoskeletal complaints past days people aged years detected subjects shoulder wrist hands fingers hip knee ankle toes cervical spine dorsolumbar spine osteoarthritis detected knee hands hip low back pain found sciatica soft tissue rheumatism shoulder tenosynovitis frozen shoulder tennis elbow golf elbow quervain tenosynovitis trigger finger carpal tunnel syndrome rheumatoid arthritis detected seronegative spondyloarthropathy ankylosing spondylitis systemic lupus erythematosus behcet disease fibromyalgia gout conclusioncompared copcord reports countries iran gets following rank musculoskeletal complaints second low back pain fourth osteoarthritis second knee osteoarthritis third soft tissue rheumatism sixth rheumatoid arthritis tenth seronegative spondyloarthropathies fifth gout eleventh fibromyalgia fifth
differential susceptibility model states given genetic variant associated increased risk pathology negative environments greater average resilience enriched ones theory first implemented psychiatric genetic research may also help unravel complex ways genes environments interact influence feeding behavior obesity reviewed evidence gene environment interactions influence obesity development aiming support applicability differential susceptibility model condition propose various environmental layers relevant human development considered bearing differential susceptibility model mind mother child relationship socioeconomic status individual response important modifiers bmi food intake interacting gene variants better worse studies date investigated obesity outcomes using approach propose differential susceptibility hypothesis fact highly applicable study genetic environmental influences feeding behavior obesity risk elsevier ltd rights reserved
farmers along amazon river year face multiple natural hazards threaten crop production limit potential agricultural development expansive floodplain active channel paper report findings study natural hazard related risk associated rice production silt bars active channel amazon river near iquitos peru data gathered four rice producing communities using household surveys households focus group discussions surveying land elevations along amazon river interpretation remote sensing imagery probability extent severity rice crop shortfalls estimated recent production years economic losses farming households also assessed findings point high risk crop shortfalls due natural hazards suggesting good year brings rice farmers bounty bad year near penury river stage reversals repiquetes edaphic conditions found problematic often cited hazard high early floods also surprisingly farmers perceptions hazards risk diverged markedly actual shortfalls experienced production years studied results provide first quantitative estimates risk due multiple natural hazards along amazon river point need assist lowland farmers risk mitigation unlock considerable potential amazon floodlands agricultural production
brief potentiostat circuit glucose sensor proposed test results potentiostat demonstrate high linearity respect glucose concentration comparable conventional potentiostat designs high linearity achieved help transconductance enhanced bulk driven operational amplifier overall current consumption circuit around potentiostat tested glucose biosensor glucose concentration ranging design realized bulk cmos process area core layout proposed low power potentiostat incorporated implantable glucose sensor system due low power operation small footprint
paper presents use memristor new element designing passivity based controllers port hamiltonian description electrical circuits memristors target dynamics assigned matching equation proposed methodology known interconnection damping assignment passivity based control inclusion memristor element extends closed loop dynamics results extra term control algorithm seen state modulated gain two mechanical examples form position control systems included show possible applications european control association published elsevier ltd rights reserved
objective many hiv positive women live well beyond menopause postmenopausal women longer risk pregnancy studies suggest may use condoms less often premenopausal women study tests hypothesis hiv positive women report trading sex cash kind payment unprotected sex common postmenopausal visits compared premenopausal visits design prospective cohort study hiv positive women years old mombasa kenya methods enrollment monthly follow visits participants completed standardized interview study clinicians collected genital samples enrollment quarterly visits menopausal status assessed annually primary outcome unprotected sex determined detection prostate specific antigen psa vaginal secretions results study followed hiv positive women contributed quarterly examination visits detection psa less frequent postmenopausal visits compared premenopausal visits versus relative risk confidence interval adjusting age diminished association menopause psa detection adjusted visits women reported sexual activity past week reported similar rates condom use postmenopausal premenopausal visits conclusions population high risk hiv positive kenyan women postmenopausal status associated greater risk unprotected sex relationship menopause unprotected sex likely context specific may differ varying risk groups regions levels exposure sexual health education
background aims ratio second fourth fingers ratio sexually dimorphic trait men tending lower values women ratio related prenatal testosterone concentrations addictive behaviors including problematic video gaming aimed investigate possible association ratios internet addiction whether relationship would independent impulsivity methods total university students women men aged years enrolled study problematic pathological internet use ppiu assessed using internet addiction test iat participants also completed barratt impulsiveness scale version bis ratios measured results ratios significantly different women ppiu adaptive internet use aiu men ppiu exhibited lower ratios hands compared aiu correlation analysis revealed ratios hands negatively correlated iat scores among men among women multiple linear regression analysis revealed age duration weekly internet use impulsiveness ratios right hand independently associated iat scores among men impulsivity mediate relationship ratios ppiu conclusions men ratios right hand inversely correlated internet addiction severity even controlling individual differences impulsivity findings suggest high prenatal testosterone levels may contribute occurrence ppiu among men
rationale matrix metalloproteinase mmp mast cells present airways people asthma objectives investigate whether mmp could activated mast cells increase asthma severity methods patients stable asthma healthy control subjects underwent spirometry methacholine challenge bronchoscopy airway smooth muscle cells grown culture second asthma group control subjects symptom scores spirometry bronchoalveolar lavage rhinovirus induced asthma exacerbations extracellular matrix prepared decellularized airway smooth muscle cultures mmp protein activity assessed measurements main results airway smooth muscle cells generated pro mmp proteolytically activated mast cell tryptase airway smooth muscle treated activated mast cell supernatants produced extracellular matrix enhanced subsequent airway smooth muscle growth fold dependent mmp activation asthma airway pro mmp fold higher control subjects mast cell numbers associated airway smooth muscle proliferation mmp protein associated bronchial hyperresponsiveness exacerbations mmp activity increased associated fall fev worsening asthma symptoms conclusions mmp activated mast cell tryptase resulting proproliferative extracellular matrix asthma mast cells associated airway smooth muscle growth mmp levels associated bronchial hyperresponsiveness mmp activation associated exacerbation severity findings suggest airway smooth muscle mast cell interactions contribute asthma severity transiently increasing mmp activation airway smooth muscle growth airway responsiveness
backgroundthe objective systematic review systematically investigate whether association inflammatory bowel disease ibd oral health methodsliterature searches randomized non randomized studies performed january risk bias within studies assessed downs black checklist across studies risk bias assessed grade framework quantitative synthesis conducted random effects meta analyses resultsa total cross sectional studies including patients included ibd associated increased risk periodontitis patients per patients confidence interval patients compared non ibd patients additionally decayed missing filled teeth index ibd patients significantly worse non ibd patients mean difference patients ulcerative colitis considerably worse oral health assessed factors quality overall evidence ranged high low due observational nature contributing studies conclusionsinflammatory bowel disease associated significantly higher risk periodontitis worse oral health compared non ibd patients however longitudinal studies needed order establish causality link ibd periodontal disease
macleamy time effort distribution curves among oft cited sources researchers interested mainstreaming building information modeling bim implementation architecture engineering construction aec industry succinctly curves offer clever answer question bim benefit aec processes however despite significant theoretical practical value little previous research conducted elaborate time effort distribution curves real life projects research aims demystify time effort distribution curves comparison representative bim project non bim project applying set innovative approaches actual time effort distribution curves two public housing construction projects hong kong produced analyzed depth curves vividly show bim implementation increases effort spent design stage throughout architecture engineering processes extra effort pays building stage curves found useful graphical analytic tool purposes adjusting fee structure among aec processes informing improved bim adoption american society civil engineers
take challenge posed horton kraftl else ways thinking children geographies children geographies research slowed methodological theoretical routes acknowledge seemingly trivial details children lives based ethnographic study australian preschool focusing children place making globalizing world paper discusses one event home corner exemplify understand enact methodological slowness event revisited recognizing role unexpected troubling paying attention data overspills research engagement conducting ideally preset qualitative research research engagements reflect also produce children lives researching global global frames practices traditions research part parcel called answers produce result nuanced complex understanding global made circulated children surfaces
although age related deficits emotion perception established using photographs individuals extension findings dynamic displays dyads beginning similarly eye tracking research person perception literature including study age differences focused individual attributes gleaned static images knowledge previous research considered cue use dyadic judgments eye tracking current study employed brunswikian lens model analysis conjunction eye tracking measurements study age differences judgment rapport social construct comprised mutual attentiveness positive feelings coordination interacting partners judgment accuracy cue utilization younger older adults operationalized correlations perceiver judgments criterion values within set brief interaction videos opposite sex college students discussed controversial topic age differences emerged accuracy judgments however pathways accuracy differed age younger adults judgments relied behavioral cues older adults addition eye tracking analyses revealed older adults spent time looking bodies targets videos whereas younger adults spent time looking targets heads contributions lens model eye tracking findings provide distinct complementary insights understanding age related continuities shifts social perceptual processing
objectives objective analyze incidence pulmonary disorders solid organ transplant recipients report outcomes patients materials methods seventy liver kidney transplant patients underwent lung biopsy pulmonary symptoms january december enrolled study examined evaluated histopathologic findings patients based clinical data recorded patients files results patients mean age years patients underwent liver transplant patients underwent kidney transplant forty six patients received organs living donors deceased donors biopsy results patients included nonspecific findings organized pneumonia tuberculosis fungal infections tumors amyloidosis diffuse alveolar damage mixed bacterial infection bronchopneumonia forty two patients died within months transplant months lung biopsy autopsies performed patients causes fatal lung diseases included fungal infections malignant tumors amyloidosis diffuse alveolar damage mixed bacterial infection aspergillosis frequently implicated lung infection occurring patients fungal infections conclusions pulmonary diseases remain important cause morbidity mortality solid organ transplant recipients fungal infection especially aspergillosis leading cause early death patients
paper presents findings integrated household water treatment reuse system agriculture soukra tunisia researchers found system internal rate return net present value range usd discount rate usd discount rate benefits included water irrigation reduced costs service providers increased agricultural production greenhouses expanded agricultural options results suggest investments rainwater harvesting greywater treatment farm level increase financial feasibility peri urban farms often faced pressure urban growth systems also help build household resilience broader environmental change lowering exposure farmers burdens associated infrequent access water poor quality soil
children sub saharan africa face stark challenges respect care wellbeing many children without risk losing parental care experiencing low levels wellbeing poverty one major risk factors loss parental care poor wellbeing often interacting risk factors family tensions violence hiv aids social protection support children care wellbeing provision income transfers complementary components sensitisation linkages social services article presents findings cross country qualitative research regarding impact social protection loss parental care support foster kinship care quality care wellbeing sub saharan africa investigates large scale nationally implemented cash transfer public works programmes ghana rwanda south africa find social protection potential support prevention loss parental care provide much needed financial support kinship foster carers improve child wellbeing quality care children direct indirect income effects well psychosocial behavioural effects programmes may also lead unintended adverse consequences result financial incentives providing care work requirements caregivers exchange transfers adequate transfer size availability child care services greater use sensitisation opportunities appropriate roles responsibilities social workers programme staff crucial improving positive impacts reducing potential negative side effects elsevier ltd rights reserved
research children autism spectrum disorders suggests differences neurotypical children preference social versus nonsocial sounds conclusions based largely use head turn methodology various limitations means establishing auditory preference present study preference assessed measuring frequency children pressed button hear different sounds using interactive toy contrary prior results groups displayed strong preference highly social sounds findings implications approaches language intervention theoretical debates regarding social motivation
propose experimentally demonstrate microwave photonic system iteratively performs principal component analysis partially correlated channel gbaud signals system presented able adapt oscillations interchannel correlations follow changing principal components system provides advantages bandwidth performance fan scalability far superior electronic counterparts wideband multidimensional techniques relevant ghz cognitive radio systems could bring solutions intelligent radio communications information sensing including spectral sensing
androgen deficiency occurs frequently men human immunodeficiency virus hiv infection antiretroviral treatments reduced prevalence male hypogonadism pathogenesis testosterone deficiency hiv multifactorial several mechanisms proposed among drugs fat redistribution poor health status could explain mechanism leading gonadotropins inhibition hypogonadotropic hypogonadism diagnosis hypogonadism hiv infected men made based clinical symptoms specific workup including measurement interpretation results biochemical testing difficult men hiv due several confounding factors treatment offered hiv infected men documented clinical hypogonadism symptoms especially losing lean mass
proton pump inhibitors ppis well known antacid drugs developed treat gastric disorders emerging studies demonstrate ppis possess biological activities extend beyond inhibition atpase proton pumps expressed parietal cells stomach extra gastric activities ppis include modulation epithelial endothelial immune cell functions recently reported ppis suppress expression several proinflammatory profibrotic molecules well enhance antioxidant mechanisms order favorably regulate lung inflammation fibrosis animal model bleomycin induced lung injury addition several retrospective clinical studies report use ppis associated beneficial outcomes chronic lung diseases including idiopathic pulmonary fibrosis ipf chronic obstructive pulmonary disease copd based preclinical clinical observations hypothesized ppis ameliorate smoke induced lung injury accordingly evaluated pharmacological efficacy ppi esomeprazole mouse model cotton smoke induced lung injury animals exposed cotton smoke weeks presence absence esomeprazole treatment found therapeutic administration esomeprazole significantly inhibited progression fibrosis throughout lungs animals group compared controls addition esomeprazole also reduced circulating markers inflammation fibrosis overall work extends emerging anti inflammatory antifibrotic potential ppis role modulation chronic lung diseases
women breast cancer frequently report distressing symptoms treatment significantly erode quality life qol symptom burden among women breast cancer complex etiology likely influenced disease treatment environmental factors well individual genetic differences purpose present study examine relationships genetic polymorphisms within neurotrophic tyrosine kinase receptor ntrk neurotrophic tyrosine kinase receptor ntrk catechol methyltransferase comt patient symptom burden qol pain fatigue anxiety depression sleep disturbance treatment breast cancer subset participants randomized clinical trial novel symptom management modality women breast cancer undergoing chemotherapy patients recruited time initial breast cancer diagnosis completed survey measures time recruitment initiation treatment surgery chemotherapy following treatment conclusion multiple linear regression analyses revealed significant associations ntrk comt single nucleotide polymorphism snp genotype symptom burden two comt variants associated specific symptoms anxiety qol measures prior initiation chemotherapy well pain interference severity treatment genotype ntrk snp associated sleep disturbance fatigue findings exploratory indicate genotypes ntrk comt may contribute relative risk symptom burden shortly period chemotherapy women early stage breast cancer
online identification dynamic properties large structures integral part structural health monitoring success vibration based condition monitoring system requires computationally efficient identification procedure potential used online computational efficiency automation two fundamental requirements effective identification procedure study propose solution bayesian based formulation online extraction structural modal parameters using output data proposed algorithm uses bayesian maximum posteriori map estimation objective function defined posterior probabilistic density estimation dynamic parameters obtained observations conditional probability distribution function pdf computed using bayesian approach minimum mean square estimation reduce computational costs propose employ adaptive filtering technique expansion truncation conditional pdf implemented consider measurement time series finite order markov processes methodology validated analyses two documented examples comparison traditional identification methods clearly shows superiority proposed algorithm findings demonstrate bayesian based methodology provides reliable modal parameter identification dynamic systems even data high noise content
several studies demonstrated quality dyadic interactions feeding impact offspring psychopathological problems families parents psychiatric diagnosis although literature addressed trans generational transmission psychopathology parents eating disorders offspring specific quality parent infant interactions feeding assessed purpose study assess possible differences quality mothers children fathers children feeding interactions months age child families parents diagnosed binge eating disorders bed sample composed italian couples parents children ntot divided three groups based presence bed diagnosis group diagnosis parents group diagnosis mothers group diagnosis fathers evaluation feeding dyadic exchanges svia italian adaptation feeding scale applied parent infant interactions families parents diagnosed bed show maladaptive features mothers fathers relate children overlapping fashion mothers showing various maladaptive symptoms fathers showing severe conflicts children meal primarily reducing parental symptoms relevant term mental health prevention programs published future academy www futureacademy org
paper propose effective accurate method optimizing space steel frames semi rigid joints using practical advanced analysis micro genetic algorithm method using beam column approach applied capturing second order effects inelastic behavior systems zero length element model employed estimating nonlinear behavior semi rigid joints utilized finding global optimal solution openmp employed perform parallel computing order efficiently reduce computational time study unlike many previous researches cross sectional areas beam column members also semi rigid connection types variables optimization results steel frame examples prove proposed method computationally efficient reliable elsevier ltd rights reserved
many university campuses united states working toward sustainable goals adopting energy green building policies require leadership energy environmental design leed certification new construction major renovation projects leed certification heavily relies whole building energy simulation demonstrate building energy performance improvement often assumed finished buildings achieve predicted level energy efficiency paper presents study compares energy model predictions actual energy performance three leed buildings university campus study shows one campus leed buildings consumed twice predicted energy usage causing high level occupant dissatisfaction investigation reveals variety contributing factors issues provides insights improve green building policy practice research findings important particular campus ohio state university way sustainability also widespread ramifications university campuses
background infusion related reactions irrs major adverse event rituximab objective develop prediction model irrs rituximab among patients cell non hodgkin lymphomas nhl setting bed university hospital tokyo methods patients nhl treated rituximab institution retrospectively analysed chills fever rash nausea asthenia headache cardiovascular symptoms respiratory symptoms grade association rituximab infusion identified irrs risk factors irrs rituximab found intergroup analysis subsequently evaluated using multivariate analysis main outcome measure occurrence irrs rituximab results total patients various types nhl including diffuse large bcell lymphoma analysed among patients assigned irr group non irr group respectively indolent histological subtypes bulky disease symptoms higher serum soluble interleukin receptor concentration bone marrow involvement common irr group multivariate logistic regression analysis identified low grade lymphomas odds ratio bulky disease independent risk factors irrs rituximab incidence rates irrs rituximab among patients neither one risk factors respectively chi conclusions simple combination histopathological subtype bulkiness disease could predict risk irrs rituximab among patients nhl
cocaine users characteristically display preferences smaller immediate rewards larger delayed rewards delay discounting proposed endophenotype cocaine addiction recent evidence suggests norepinephrine system specifically alpha adrenergic receptor adraa impacted chronic cocaine use also potentially involved neural mechanisms underlying hence investigated effects adraa polymorphisms adraa mrna expression levels cocaine users stimulant naive controls two hundred twenty three participants cocaine users stimulant naive healthy controls completed computerized paradigm genotyped three single nucleotide polymorphisms snps adraa gene peripheral adraa mrna expression quantified whole blood samples three snps near perfect linkage disequilibrium accordingly significant group genotype interactions found three adraavariants revealing steeper cocaine users controls carrying allele snp allele allele similarly high adraa mrna expression levels significantly associated reduced tendency choose smaller immediate rewards larger delayed rewards cocaine users controls relationship cocaine use moderated adraa snps peripheral adraa gene expression propose norepinephrine systemis involved deficits observed cocaine using individuals consequently pharmacological compounds targeting adraasmight considered symptom specific treatment delay aversion stimulant addiction
pentaprism scanning system widely used measurement large flat wavefront based property deviated beam motion pitch direction manufacturing position errors pentaprisms bring error measurement good error analysis method indispensable paper propose new method building mathematic models pentaprism size angle errors pentaprism put model parameters size parameters selected determine size angle parameters selected determine angles pentaprism yaw roll pitch used describe position error pentaprism autocollimator pentaprism scanning system wavefront test simulated ray tracing using matlab design method separating constant measurement results improve measurement accuracy analyze system error monte carlo method method simple rapid accurate convenient computer programming
reducing chlorophyll chl content may improve conversion efficiency absorbed photosynthetically active radiation biomass therefore yield dense monoculture crops improving light penetration distribution within canopy effects reduced chl leaf canopy photosynthesis photosynthetic efficiency studied two reportedly robust reduced chl soybean mutants comparison wild type clark cultivar mutants characterized growing season whereas mutant characterized growing season chl deficiency led greater rates leaf level photosynthesis per absorbed photon early growing season mutant chl content similar effect photosynthesis later season mutant leaf chl approached transient benefits reduced chl leaf level translate improvements canopy level processes reduced pigmentation mutants linked lower water use efficiency may dampened photosynthetic benefits reduced chl especially since growing seasons experienced significant drought conditions results confirming hypothesis earlier published study mutant significantly outyielded demonstrate soybean significantly overinvests chl despite chl reduction little negative impact biomass accumulation yield small negative effects present likely due pleiotropic effects mutation outcome points opportunity reinvest nitrogen energy resources would otherwise used pigmentproteins increasing biochemical photosynthetic capacity thereby improving canopy photosynthesis biomass production
background parathyroid hormone pth effective anti osteoporosis agent binding receptor pthr several signaling pathways including camp protein kinase pka phospholipase plc protein kinase pkc initiated proteins camp pka pathway major pathway earlier studies reported pthr might also activate pkc via plc independent mechanism pathway remains unclear material methods hek cells camp accumulation measured elisa pkc measured fluorescence resonance energy transfer fret analysis using ckar plasmid mct cells real time pcr performed examine gene expressions assays cell apoptosis cell differentiation alkaline phosphatase activity mineralization performed results fret analysis found pth pth pth activated pkc pkc activation ability blocked camp inhibitor camp rescued addition active pka alpha pka beta pkc activation ability partially inhibited camp mct cells gene expressions alp cited nra osx regulated significantly changed pan pkc inhibitor pretreatment camp gene expressions alp cited opg differentially regulated difference blunted pth significantly decreased early apoptosis augmented osteoblastic differentiation accordance activities pka pkc conclusions plc independent pkc activation induced pth could divided two potential mechanisms one pka dependent associated pth pka independent associated pth also found pth could activate plc independent pkc via pka dependent mechanisms
power concepts promise reduction greenhouse gas emissions simultaneously guaranteeing safe energy supply even high share renewable power generation thus becoming cornerstone sustainable energy system power syngas electro chemical conversion steam carbon dioxide use renewably generated electricity syngas production synfuels high value chemicals offers efficient technology couple different energy intense sectors traffic transportation chemical industry syngas produced electrolysis thus regarded key enabling step transition energy system offers additionally features valorization closed carbon cycles discuss advantages current limitations low high temperature electrolysis advances fundamental understanding basic reaction schemes stable high performance materials essential promote electrolysis
well known gouy stodola theoremstates device produces maximum useful power working reversibly entropy production inside device statement leads method thermodynamic optimization based entropy production minimization exergy destruction difference exergy fuel exhausts also given entropy production inside device therefore assessing efficiency device exergy analysis also based gouy stodola theorem however assumptions led gouy stodola theorem satisfied several optimization scenarios non isothermal steady state fuel cells entropy production minimization exergy analysis used caution demonstrate using non equilibrium thermodynamics cases entropy production minimization exergy analysis applied
aim study determine whether incidence pneumonia patients taking clozapine frequent compared taking risperidone atypical antipsychotics admission tertiary care medical center retrospective case matched study general medicine patients month period july july detailed electronic medical records analyzed explore association use two atypical antipsychotics incidence pneumonia patients clozapine group documented pneumonia compared risperidone group general population group clozapine compared untreated general population associated increased risk pneumonia odds ratio confidence interval however significant increase risk pneumonia associated use risperidone odds ratio confidence interval clozapine use associated increased risk pneumonia may related immunologic factors side effects sedation drooling make aspiration likely although causative mechanisms require investigation findings suggest providers use added caution choosing candidates clozapine therapy
full understanding hydrodynamic processes within jet produced manoeuvring ship propeller essential development maintenance ports docks harbours investigation predominant axial velocity component within freely expanding wash studied flow fields formed four propellers operating four power levels speeds rotation investigated bollard pull conditions absence rudder within large free surface tank using laser doppler anemometry characteristics propellers extended range high accuracy measurements previously attempted comparison made existing methodologies prediction magnitudes axial velocity made deficient modifications methodologies developed presented jets found produce maximum axial velocity along initial efflux plane location near blade mid span position magnitude axial velocity seen decrease jet entrained flow transitioned zone flow establishment zone established flow elsevier ltd rights reserved
nelson narens journal verbal learning verbal behavior general knowledge norms valuable researchers many fields however much changed years since norms example people knew answer question name lone ranger indian sidekick answer tonto whereas people know answer thus updated norms expanded providing new measures particular report two new metacognitive measures confidence judgments peer judgments provide detailed report commission errors measures valuable researchers together likely facilitate future research number fields research investigating memory illusions metamemory processes error correction presence substantial generational shifts necessitates use updated norms
retrieval induced forgetting rif phenomenon wherein practicing recalling items impairs recall semantically related unpracticed items two experiments examined whether explicitly warning older experiment younger adults experiments rif different times two exposures retrieval practice paradigm would affect participants forgetting participants experiments either warned encoding retrieval practice recall warning combined integration instructions experiment warnings reduce forgetting either age group experiment forgetting increased across exposures cases older adults experienced forgetting younger adults combining integration instructions warning also reduce younger adults forgetting relative baseline conditions experiment results indicate younger older adults susceptible retrieval induced forgetting raising awareness phenomenon increases rather decreases forgetting rates
alcohol use disorders substance use disorders antisocial personality disorder share common externalizing liability may also include attention deficit hyperactivity disorder adhd however studies compared formal quantitative models externalizing liability aim delineating categorical continuous nature liability community study compares categorical continuous hybrid models externalizing liability data derived national epidemiologic survey alcohol related conditions seven disorders modeled childhood adhd lifetime diagnoses antisocial personality disorder aspd nicotine dependence alcohol dependence marijuana dependence cocaine dependence substance dependence continuous latent trait model provided best fit data measurement invariance analyses supported fit model across genders females displaying significantly lower probability experiencing externalizing disorders cocaine dependence marijuana dependence substance dependence alcohol dependence aspd nicotine dependence adhd provided greatest information respectively underlying externalizing continuum liability externalizing disorders continuous dimensional severity findings important implications organizational structure externalizing psychopathology psychiatric nomenclatures
roaded catchment representative type artificial catchment rainwater harvesting rainfall runoff threshold value main factor influences system efficiency cost antecedent soil moisture condition important factor impacts determination rainfall runoff threshold value study rainfall antecedent soil moisture condition runoff relationships potential efficiency rcs presented rainfall runoff data monitored research sites merredin mount barker used determine relationship two antecedent moisture criteria antecedent moisture conditions amc average antecedent precipitation aap used analyse relationship previous rainfall soil moisture monitored results show amc suitable show relationship rainfall antecedent soil moisture condition dryland western australia recommended use aap determine relationship
thesis analyses image aunt two periods time enforcement china birth control policy periods character alienated first angel devil reason person seen differently barbaric crazy carrying birth control policy made government
studies crowding document incentives sometimes backfiredecreasing motivation prosocial tasks present research demonstrated additional channel incentives harmful incentivized advocates cause perceived less sincere nonincentivized advocates ultimately less effective persuading people donate negative effects incentives hold incentives imply selfish motive advocates offered matching incentive told donations successfully solicit matched incompatible altruism perform well incentivized thus incentives may affect prosocial outcomes ways previously investigated crowding individuals sincerity expression thus ability gain support cause
mindfulness based therapies mbts eating disorders show potential benefit outcomes yet evidence scarce regarding mechanisms influence remission symptoms one way mindfulness approaches create positive outcomes enhancement emotion regulation skills maladaptive emotion regulation key psychological feature eating disorders aim current study identify facets emotion regulation involved relationship mindfulness maladaptive eating behaviours three cross sectional studies clinical non clinical female participants completed eating disorder inventory edi eating specific scales drive thinness bulimia edi psychological symptom scales emotion dysregulation interoceptive deficits mindfulness impulsivity emotion regulation questionnaires samples mindfulness significantly inversely associated edi eating psychological symptom scales impulsivity non clinical samples interoceptive deficits mediated relationship mindfulness edi eating specific scales non acceptance emotional experience facet interoceptive awareness mediated relationship mindfulness eating specific edi scores investigations could verify relationships identified mindfulness based approaches optimised enhance emotion regulation skills sufferers risk eating disorders
august special issue safety science contested foundations safety science scientific domain methodological theoretical philosophical grounds safety specialists social behavioural organisational sciences discussed seems identity crisis occupational safety social sciences tension scientific societal relevance notion safety noted raising doubts scientific validity safety science safety science three founding fathers safety science group ssg delft university technology dut challenged debate reflect ambitions mission expressed inception safety science dut addition already described hale kroes hale elaborate also personal experiences insights gained period years work additional experiences gained particular first two authors transport domain technological engineering design methodological perspective provide encompassing scope development safety science general scientific activity dut parallel developments domains described papers hale hale kroes irst correct long term omission translating founding documents safety science dut english make accessible non dutch experts second highlight development three basic notions identified inception ssg cornerstones safety science scientific discipline matter domain related interdisciplinarity problem solving orientation systems approach document paper development use transport domain dut whole broadly ssg third discuss general observations particularly first two authors value unique role safety investigation methodology systems engineering powerful feedback loops learning potential drivers change potential address safety complex dynamic open transport systems fourth elaborate three additional basic notions needed extra building blocks paradigm shift safety thinking irrespective disciplines domains full information supply engineering design methodology multiple intervention strategies finally advocate mutual recognition value validity scientific paradigms developed various disciplines conjunction constitute safety science distinct multidisciplinary activity academic community elsevier ltd rights reserved
introduction external beam radiation therapy patients left breast cancer mastectomy site may cause myocardial perfusion abnormalities intended study change abnormalities short long term post radiotherapy follow methods twenty patients left patients right breast cancer comprised exposed control groups respectively patients low risk coronary disease underwent myocardial perfusion scans mps years external beam radiation therapy bed modified radical mastectomy subjects recruited two bigger cohorts previously reported data scans months scans acquired injections mci mibi peak pharmacologic stress rest change perfusion abnormalities visual assessment quantifications autoquant baseline years follow time compared exposed control patients results exposed patients visual perfusion abnormality scores compared control subjects indices perfusion abnormality normalized control subjects baseline follow scans summed difference score summed stress score difference perfusion abnormalities exposed unexposed subjects remained unchanged along years follow conclusion radiation induced myocardial perfusion abnormalities patients left breast cancer could cause permanent coronary disease time
symptomatic androgen deficiency common patients taking opioid analgesics drugs potently suppress hypothalamic pituitary gonadal axis however efficacy testosterone replacement setting remains unclear objective trial evaluate efficacy testosterone replacement pain perception androgen dependent outcomes men opioid induced androgen deficiency conducted randomized double blind parallel placebo controlled trial outpatient academic research center participants men aged years opioid analgesics chronic noncancer pain total testosterone levels participants randomly assigned weeks daily transdermal gel contained testosterone placebo primary outcomes changes self reported clinical pain objectively assessed pain sensitivity sexual function quality life body composition also assessed mean age years median total free testosterone levels baseline testosterone placebo arm respectively randomized participants follow data efficacy outcomes compared men assigned placebo arm assigned testosterone replacement experienced greater improvements pressure mechanical hyperalgesia sexual desire role limitation due emotional problems testosterone administration also associated improvement body composition group differences changes self reported pain conclusion men opioid induced androgen deficiency testosterone administration improved pain sensitivity sexual desire body composition aspects quality life
study sought explore parental perceptions body image preschoolers conducted semi structured interviews primary caregivers preschoolers examine knowledge beliefs strategies regarding early body image socialization families thematic analysis yielded three themes highlighting knowledge gaps belief discrepancies limited awareness strategies findings regarding knowledge participants defined body image objective attractiveness rather subjective self assessment focused negative body image beliefs although participants believed weight shape impact children self esteem believed preschoolers young body image strategies participants said family primary influence body image identified effective strategies said anything influence children body image findings suggested family body image socialization preschoolers occurring outside awareness parents concept positive body image underdeveloped elsevier ltd rights reserved
present collaborative teaching model used practical classes manufacturing engineering model developed teachers one innovative educational groups nuevas metodologias docentes ingenieria mecanica fabricacion new learning methodologies mechanical engineering manufacturing universidad politecnica madrid upm implemented five degrees presently taught escuela tecnica superior ingenieria diseno industrial etsidi faculty engineering industrial design upm model traditional practical lessons combined web platform developed named plataforma educativa practicas academicas pepa academic learning platform practical classes allows automatic registration results laboratory classes evaluations teachers automatically manually published elsevier ltd
background patients atopic dermatitis susceptible several viruses including herpes simplex virus hsv patients experience episodes severe skin infection caused hsv termed eczema herpeticum numerous mouse models established model exists objective sought establish characterize mouse model methods infected like skin lesions hsv induce severe skin lesions dermatitis prone mouse strain nga gene expression investigated using microarray quantitative pcr antibody titers measured means elisa natural killer cell cytotoxic cell regulatory cell follicular helper cell populations evaluated using flow cytometry role cells hsv induced development severe skin lesions examined means depletion adoptive transfer results inoculationofhsvinducedsevereerosiveskinlesionsin eczematousmice impaired skinbarrier butmilder lesionsinsmallnumbersofnormalmice eczematousmiceexhibited lowernkcellactivitybutsimilarcytotoxict cellactivityand humoralimmuneresponsescomparedwithnormalmice theroleof nkcellsincontrollinghsv inducedskinlesionswasdemonstrated byexperimentsdepletingortransferringnkcells conclusion murine model impaired skin barrier established study demonstrated critical role defective activities development hsvinduced severe skin lesions eczematous mice
cloud computing distributed computing model lot drawbacks faces difficulties many new innovative emerging techniques take advantage features paper explore security threats risk assessments cloud computing attack mitigation frameworks risk based dynamic access control cloud computing common security threats cloud computing explored threats addressed acceptable measures via governance effective risk management using tailored security risk approach existing threat risk assessment tra schemes cloud services use converse thinking approach develop theoretical solutions minimizing risk security breaches minimal cost study propose improved attack defense tree mechanism designated iadtree solving tra problem cloud computing environments
research boundary layer receptivity key issue laminarturbulent transition prediction fluid mechanics many previous studies local receptivity basis parallel flow assumption accurately reflect real physics overcome disadvantage local receptivity non parallel boundary layer studied paper direct numerical simulation dns difference non parallel parallel boundary layers local receptivity investigated addition effects disturbance frequency roughness location multiple roughness elements receptivity also determined besides relations receptivity amplitude free stream turbulence fst roughness height roughness length ascertained well tollmien schlichting wave packets excited non parallel boundary layer interaction fst localized wall roughness group waves separated fast fourier transform obtained results accordance dietz measurements theoretical calculations linear stability theory lst
cooperative relationships groups difficult high human capability differentiate group group members obstacle exists even groups obtain benefits cooperation groups rational cooperation based interactionist approach authors propose personal individual differences situational conflicts factors contribute rational intergroup cooperation authors conducted preliminary correlational study study experimental investigation study study authors examined participants psychometric properties spanish version rational experiential inventory rei measuring individual differences information processing study authors conducted experimental investigation participants testing role individual differences conflict intergroup rational cooperation findings study showed scale adequate psychometric properties results study confirmed existence manipulated perceived intergroup conflict reduces magnitudes relationships rational ability rational cooperation addition perceived intergroup conflict increased magnitude links experiential ability experimental engagement rational cooperation individual differences previous conflict role predicting rational intergroup cooperation according interactionist approach personal situational factors considered understanding intergroup relationships
program administrator total cost saved energy allow comparison cost efficiency across utilities states program types identify potential performance improvements comparing program administrator cost total cost saved energy indicate degree programs leverage investment participants based reported total costs savings information utility efficiency programs estimate savings weighted average total cost saved electricity across states per kilowatt hour comparing favorably energy supply costs retail rates programs targeted residential market averaged per compared per nonresidential programs lighting programs average total cost per drove lower savings costs residential market provide estimates common program types find program administrators participants average splitting costs efficiency half consistent standardized complete reporting efficiency programs needed differing definitions quantification costs savings savings lifetimes pose challenges comparing program results reducing uncertainties could increase confidence efficiency resource among planners policymakers
prokinetic cisapride important therapeutic option functional gastrointestinal disorders withdrawn market years ago due rare severe side effects likewise use metoclopramide mcp domperidone functional disorders fgid restricted consequently leaving therapeutic gap clinical practice systematic review revealed herbal medicinal product hmp stw presents therapeutic option equivalent mcp cisapride stw hmp efficacy shown randomized controlled clinical trials rcts functional dyspepsia irritable bowel syndrome based multitarget effect numerous etiological factors due outstanding favorable safety profile stw allows effective safe use fgid without limitation duration treatment
study qualitative analysis sixth graders responded varying homework prompts media literacy education curriculum focused prevalence media violence gender stereotypes media textual analyses constant comparisons suggested students engagement critical thinking differed across prompts provided media literacy facilitators primarily responses question production distribution violent media compared students received prompt referenced entertainment problematic aspects production circulation violent content students received unfavorable prompt prompt likely demonstrate richer thinking beyond mere description discuss potential implications media violence audiences consider profit seeking aspect media industries
purpose study evaluate health related quality life among patients ankylosing spondylitis rheumatoid arthritis systemic lupus erythematosus sle prospective cross sectional survey conducted september august patients answered questions regard demographics disease characteristics also completed generic preference based utility instruments multivariate analysis assessed relationship sle respect outcomes different health related quality life instruments general baseline disease characteristics differed across three disease groups compared sle patients patients scored worse higher order summary scores physical pcs mental components mcs total also worse pcs sle patients scored higher utility score compared patients higher patients utility score multivariate analysis found compared patients significantly lower total score pcs sle patients greater pcs greater utility score multivariate analysis found difference across patient groups respect mcs utility score findings suggest among three rheumatic diseases studied patients worse health related quality life patients similar poorer health related quality life sle patient
series fluorinated nucleosides prepared tested anti hcv activity among triphosphate fluoro methyl adenosine nucleoside potent selective inhibitor nsb polymerase maintained activity resistance mutant number phosphoramidate prodrugs prepared evaluated leading identification aminocyclobutane carboxylic acid isopropyl ester variant favorable pharmacolcinetic properties including efficient liver delivery animals published elsevier ltd
mainstream memory literature recollection conceptualized univariate process involves conscious reinstatement contextual details accompanied earlier events conception predominates several domains basic memory research cognitive development cognitive neuroscience dementia forensic interviewing according dual recollection hypothesis however distinct forms recollection conscious reinstatement contextual details context recollection conscious reinstatement target events per target recollection review existing lines evidence favor dual recollection hypothesis describe source monitoring paradigm accompanying model separates recollections familiarity experiments reported whose aims determine measures target context recollection react series theoretically motivated manipulations assess validity modeling tool supplies measurements manipulations produced series single double dissociations target recollection context recollection familiarity subsequent state trace analyses revealed retrieval processes jointly independent fit analyses showed model gave acceptable accounts data experiments fit unacceptable either target recollection process context recollection process removed model
adoption computational thinking increasing classrooms curricula one population could benefit early instruction students autism spectrum disorders asd unfortunately many individuals asd lack social competencies successfully navigate work environment purpose paper discuss digital games based learning intervention youth asd learn computational thinking social skills dubbed virtuoso intervention targets youth asd gain social skills working together solve introductory computer programming problems virtual programmable robots one objective create learning materials embed social competency instruction within focused curriculum another objective develop immersive space participants work together curricular content using educational design research methods developing refining instructional interventions maximize educational impact
study evaluates electrical energy use patterns nigerian food beverage industries fbi period years aim developing index measures energy efficiency producing finished product data used study consist monthly diesel consumption liters electricity consumption kwh mass finished product unit mass energy content finished product findings reveal diesel generators account electrical energy needs industry respectively effort ensure uninterrupted power supply production process average electrical energy use index industry determined industry values indicate neither industries efficiently utilized electrical energy production processes inefficient usage electrical energy finished product attributed usage inefficient electric motors non compliance usage energy saving equipment diesel leakage generating sets
hereditary angioedema hae group three uncommon potentially fatal conditions transmitted somatic dominant trait recognized trigger attacks dental treatment tooth extraction frequently reported published work clinical symptoms may manifest many hours even days procedure describe recent case australia death resulted hae following dental extraction discuss post mortem presentation diagnosis highlighting need dental practitioners aware condition
conventional hybrid simulation real time hybrid simulation rths applications information exchanged experimental substructure numerical substructure typically restricted interface boundary conditions force displacement acceleration etc additional demands placed rths recent advances recursive system identification techniques opportunity arises improve fidelity extracting information experimental substructure online model updating algorithms enable numerical model components herein named target model similar physical specimen modified accordingly manuscript demonstrates power integrating model updating algorithm rths rthsmu explores possible challenges approach practical simulation two bouc wen models varying levels complexity used target models validate concept evaluate performance approach constrained unscented kalman filter cukf selected using model updating algorithm accuracy rthsmu evaluated estimation output error indicator model updating output error indicator system identification error indicator results illustrate applicable constraints integrating model updating rths global response accuracy improved target model unknown discussion model updating parameter sensitivity updating accuracy also presented provide guidance potential users elsevier ltd rights reserved
study used situational theory problem solving stops investigate communication behaviors publics formed around intensively publicized policy issue results surveying participants online support utility stops segment hot issue public active communication general population chinese context however problem recognition significantly correlate situational motivation examined cross situational variables party identity serves better identifier hot issue public subgroups trust government theoretical implications hot issue publics stops practical implications effective communication hot issue discussed
considering ecological security strategy new promoting urbanization important develop vernacular architecture tibetan plateau serving ecological security barrier china development urban rural integration process whole popularit modernization conception significant change happens daily life style also production mode paper analyzes yard layout flat type system building materials zhuang kuo flok due widespred usage unigue characterisics combing green architecture elements efforts made design new zhuang kuo flok style building based regional features
paper models left handed system finite inductively interacting elements separate internal energy generic double spectral parametrization proposed microcanonical formalism analytically allows derive entropy temperature heat capacity energy set particularly heat capacity found negative high energies analytical findings supported numerical results interestingly numerically heat capacity system seems decline increasing internal energy sets elsevier rights reserved
due environmental safety limitations exhaust emissions internal combustion engine become severe important pollutants diesel engine oxides nitrogen particulates hydrocarbon carbon monoxide found literature various cylinder combustion treatment methods ceramic coating piston diamond like carbon coating piston zirconia coating piston various ceramic coatings cylinder head liner used diesel engines improve performance reduction various emissions present investigation attempt made study performance emissions direct injection diesel engine using nano catalyst nano coated pistons pistons coated copper cadmium nano catalyst top piston using plasma spraying techniques engine performance emission characteristics compared baseline engine observed significant improvement performance reduction various pollutants emitted diesel engine
paper introduce rotating skip list fastest concurrent skip list date existing concurrent data structures experience limited scalability growing core count two main reasons threads contend accessing shared data require chip communication synchronize solution combines rotation tree maintain logarithmic complexity deterministically skip list structure avoid tree root bottleneck locks limit cache line bouncing combination requires trade usual skip list towers wheels novel algorithmic design favors spatial locality allows constant time restructuring operation evaluate performance skip list amd opteron intel xeon multicores show rotations guarantee balance compare performance seven state art skip lists trees using four different synchronisation techniques rotating skip list shows unprecedented peak performance mops second copyright john wiley sons ltd
purpose report histopathological features anterior subcapsular cataract associated atopic dermatitis case report year old man atopic dermatitis presented bilateral anterior subcapsular cataract routine cataract surgery anterior subcapsular cataractous tissue obtained anterior capsulorhexis flap prepared wholemount histological analysis wholemount consisted well demarcated central grayish white plaque surrounded transparent capsule corroborating slit lamp biomicroscopic appearance higher magnification plaque revealed fibrous amorphous mass likely extracellular matrix owing presence irregularly arranged bundled strands fibrils typical collagen lens epithelial cells plaque densely packed myofibroblast like immunoreactive alpha smooth muscle actin contrast lens epithelial cells distant plaque retained regular cuboidal arrangement regular spacing labeled alpha smooth muscle actin similar lens epithelial cells obtained non cataractous case conclusions presence alpha smooth muscle actin reactive elongated cells plaque suggests cuboidal lens epithelial cells making anterior subcapsular cataract transdifferentiated spindle shaped myofibroblastic cells produce deposit aberrant extracellular matrix transdifferentiation process commonly known epithelial mesenchymal transition contributes fibrotic response leading development human anterior subcapsular cataract
sets common features essential assets reused fulfilling specific needs software product line methodology requirements reuse extraction software features software requirement specifications srs viable practitioners access software artefacts due organisational privacy srs always kept confidential easily available public alternatives researchers opted use publicly available software descriptions product brochures online software descriptions identify potential software features initiate process aim paper propose semi automated approach known feature extraction reuse natural language requirements fenl extract phrases represent software features software reviews absence srs way initiate process fenl composed four stages depend keyword occurrences several combinations nouns verbs adjectives experiment conducted phrases could reflect software features reside within online software reviews extracted utilising techniques information retrieval area way demonstrate feature groupings phase semi automated approach group extracted features conducted assistance modified word overlap algorithm evaluation proposed extraction approach evaluated experiments truth data set created manually performance results obtained feature extraction phase indicates proposed approach performed comparably related works terms recall precision measure elsevier rights reserved
background aim study compile nationally representative statistics describing inpatient hospital care patients work related injuries illnesses covered workers compensation insurance united states methods three years data nationwide inpatient sample nis used describe inpatient stays respect patient hospital characteristics principal diagnoses number type procedures provided total charges length stay time admission administering principal procedure results approximately hospitalizations occurred annually representing inpatient admissions average total charge per hospitalization adjusting type diagnosis factors hospital care found involve procedures slightly longer length stay take less time admission principal procedure inpatient care comparable diagnoses paid sources inpatient care disc spinal disorders paid higher charges similar non cases three year trends showed steady decline number hospitalizations sharp rise total charges per stay conclusions research provides initial foundation understanding extent nature hospitalized care injured workers identifying significant trends delivery care wiley liss inc
understand root growth responds temperature used kinematic analysis quantify division expansion parameters root arabidopsis thaliana plants grown temperatures degrees given continuously germination temperatures root length varies threefold wild type twofold double mutant phytochrome interacting factor kinematics spatial profile velocity obtained new software stripflow find degrees truncates elongation zone curtails cell production responses probably reflect elicitation common pathway handling severe stresses curiously rates cell division temperatures closely correlated rates radial expansion degrees root growth rate maximal elemental elongation rate final cell length scale positively temperature whereas length meristem scales negatively non linear temperature scaling characterizes meristem cell number time transit either meristem elongation zone average cell division rate surprisingly length elongation zone total rate cell production temperature invariant constancies implications understanding underlying cellular processes integrated
electric motor heart electric vehicle crucial occurring faults detected promptly catastrophic failure avoided time deep knowledge degradation mechanisms required allow maximum performance minimum cost paper focuses balance statistical results measurements unaged accelerated aged winding insulation samples provide information degradation processes enabling steps toward reliable prognosis model motor remaining life
background suffix arrays variants used widely representing genomes search applications enhanced suffix arrays esas provide fast search speed require large auxiliary data structures storing longest common prefix child interval information explore techniques compressing esas accelerate genomic search reduce memory requirements results evaluate various bitpacking techniques store integers fewer bits well bytecoding methods reserve single byte per integer whenever possible results fly chicken human genomes show bytecoding exception guide array fastest method retrieving auxiliary information genomic searching accelerated using data structure called discriminating character array reduces memory accesses suffix array genome string finally integrating storage auxiliary discriminating character arrays speeds genomic search conclusions combination exception guide arrays discriminating character array integrated data storage provide fold increase speed genomic searching compared using bytecoding alone faster space efficient uncompressed esa
energy efficiency urban infrastructure large part influenced efficient utilization transportation building systems opportunities efficient utilization transportation building systems available context commercial office building site selection office location decision makers opportunity select buildings locations potentially minimize building transportation energy consumption within given urban context objective research presented paper apply calculation framework estimating potential transportation energy building energy consumption commercial office building site alternatives calculation framework applied case studies commercial office buildings sites represent typical developments found transportation land use context atlanta georgia metropolitan region framework leverages building energy simulation models regional travel demand model data estimate energy performance uncertainty importantly calculation results indicate transportation major determinant commercial office building site energy performance incorporation framework sustainable development policy market transformation tools green building rating systems could accommodate performance based planning efficient infrastructure utilization american society civil engineers
major depressive disorder mdd predicted second leading cause disability worldwide year currently available treatments mdd suboptimal mdd patients recover less weeks adequate treatment patients fail adequately respond currently available interventions moreover current treatments come cost significant central nervous system cns side effects highlighting need effective treatments fewer side effects greater mechanistic understanding mdd actions antidepressant drugs would provide opportunities development novel therapeutic approaches treatment aim mind explore novel empirically supported hypothesis evolutionarily ancient thermoafferent pathway signaling via spinoparabrachial pathway serotonergic sensory cells skin epithelial linings serotonergic neurons depression related circuits brain dysfunctional mdd antidepressant therapies including antidepressant drugs exercise act restoring function elsevier inc rights reserved
objective purpose current study compare donor age variation chondrocytes non osteoarthritic trauma joints patients young middle age years embedded matrix associated autologous chondrocyte transplantation mact grafts cares chondrocyte specific gene expression cares grafts compared chondrocytes joints patients aged years embedded collagen type hydrogel design chondrocytes articular chondrocyte laden grafts cultured days chondrogenic growth medium performed reverse transcriptase quantitative polymerase chain reaction qpcr evaluate mrna expression levels chondrocyte specific hypertrophic markers results gene expression analysis qpcr revealed significant difference chondrocyte specific genes cola acan sox sox sox among different age group patients cares grafts comparative analysis chondrocytes articular chondrocytes chondrogenic markers cola sox exhibited higher expression chondrocytes hypertrophic cartilage pathogenesis marker mmp mmp expression higher cola significantly lower expression chondrocytes articular chondrocytes cultivated collagen type hydrogels conclusion summary identify donor age variation influence chondrogenic gene expression cares system also identified freshly isolated chondrocytes embedded collagen type hydrogels exhibit chondrogenic gene expression observed articular chondrocytes cares grafts transforming chondrocytes articular chondrocytes regarded alternative option mact technique
gender roles masculinity femininity considered descriptive behaviour also prescribe men women behave assess prescriptive nature gender roles previous research asked participants assign masculine agentic feminine communal traits men women differing occupational roles current study conducted australia sought establish whether previous results still apply contemporary prescriptions masculine feminine traits men women different occupational roles specifically employee homemaker roles participants completed online questionnaire masculine feminine traits identified bem sex role inventory short form ascribed men women different occupational roles employee homemaker compared previous results current differ fundamental ways posit reflect social changes women results discussed relation previous research response social change
immunological milieu placenta may crucial priming developing foetal immune system early imbalances may promote establishment immune mediated diseases later life including allergies initial exposure allergens seems occur utero little known allergen induced placental cytokine chemokine release release several cytokines chemokines placenta tissue exposure mast cell degranulator compound apple allergen placentas allergic healthy mothers analysed four placentas women apple allergy three controls applied placental perfusion model two separate cotyledons simultaneously perfused without apple allergen mal two control placentas perfused compound outflow histamine quantified spectrophotofluorometrically tnf ifn gamma cytometric multiplex bead array cxcl cxcl ccl ccl house multiplex luminex assay compound induced rapid release histamine cxcl cxcl ccl ccl factors apple allergen induced time dependent release tnf histamine placentas women apple allergy compared unstimulated cotyledon ccl levels slightly increased allergen stimulation control placentas allergens induce placental cytokines chemokines distinctly allergic healthy mothers mediators may affect prenatal development immune system modify risk diseases related immune disorders childhood allergies elsevier ireland ltd rights reserved
low levels cell free mitochondrial dna mtdna cerebrospinal fluid csf alzheimer disease patients identified proposed novel biomarker disease lack validation studies previous results prompted replicate finding comprehensive series patients controls applied droplet digital polymerase chain reaction csf specimens patients representing spectrum neurologically healthy controls following pre analytical analytical parameters evaluated effect freeze thaw cycles mtdna linearity mtdna load across serial dilutions mtdna levels diagnostic groups found wide range mtdna copies resulted high degree overlap groups although group presented significantly higher mtdna counts receiver operating characteristic analysis disclosed area curve distinguish patients controls mtdna highly stable low analytical variability conclusion mtdna levels csf show high interindividual variability great overlap within phenotypes presents low sensitivity elsevier inc rights reserved
paper describes design implementation tool extract imdb dataset files import database approach differs published tools research previous work used relational databases tool uses document oriented data structures allows others augment code change structures based needs project development required use technologies currently demand web developers software engineers allows developers fork copy work utilize work addition provided project team opportunity develop additional marketable skills finally web interface perform queries import data validate import process also developed queries include searching people names searching movie titles viewing specific data individual person movie title
aimsinsular cortex involved processing information pain aim study investigate roles mechanisms receptors pxrs development visceral hypersensitivity adult rats neonatal maternal deprivation nmd methodsvisceral hypersensitivity quantified abdominal withdrawal reflex threshold colorectal distension crd expression pxrs determined qpcr western blot synaptic transmission recorded patch clamp recording resultsthe expression pxrs glutamatergic neurotransmission significantly increased nmd rats compared age matched controls application bzatp pxr agonist enhanced frequency spontaneous excitatory postsynaptic currents sepsc miniature excitatory postsynaptic currents mepsc slices control rats application bbg pxr antagonist suppressed frequencies sepsc mepsc slices nmd rats microinjection bzatp right significantly decreased crd threshold control rats microinjection bbg right greatly increased crd threshold nmd rats conclusiondata suggested enhanced activities pxrs likely presynaptic mechanism contributed visceral hypersensitivity adult rats nmd
study investigated person perception respect variables associated affect music tempo mode following motor synchronization music participants female tested task involving stepping researcher beat slow fast music major minor mode following measures concerning synchronised partner collected incidental memory likeability similarity prosocial attitude towards significant effects found likeability measure modulated gender suggesting variables associated affect perception music mode tempo appear relevant person perception synchronization task ways differ men women results proof concept study indicate need research effect motor synchronization based ecologically valid musical interaction tasks
background van wyk grumbach syndrome vwgs rare presentation juvenile hypothyroidism manifests females chronic autoimmune hypothyroidism isosexual pseudoprecocious puberty multicystic ovaries uniquely presents short stature delayed bone age unlike causes precocious puberty kocher debre semelaigne kdss rare presentation juvenile hypothyroidism manifesting calf muscle pseudohypertrophy delayed contraction relaxation reflexes percussion myxedema objectives diagnose rare association vwgs kdss conduct follow patient replacement therapy methods present case year old female child presented endocrine department complaints intermittent vaginal bleeding short stature difficulty walking evaluation found autoimmune hypothyroidism fsh dominated isosexual pseudoprecocious puberty delayed bone age secondary pituitary macroadenoma delayed relaxation deep tendon reflexes pseudohypertrophy calf muscles diagnosis vwgs associated kdss made patient initially put thyroxine replacement titrated accordingly followed months year results features syndrome improved months adequate thyroxine replacement conclusions vwgs kdss rare presentations juvenile hypothyroidism association even rarer early diagnosis prompt replacement therapy avoid unnecessary investigations surgical interventions european thyroid association published karger basel
inherited genetic variants contribute risk factors developing alcohol use disorder polymorphisms may inform precision medicine strategies treating alcohol addiction targeting genetic mutations linked alcohol phenotypes provided promising initial evidence reducing relapse rates alcoholics although successful studies conflicting findings reports adverse effects may ultimately limit clinical utility suggesting novel pharmacogenetic targets necessary advance precision medicine approaches describe promising novel genetic variants derived preclinical models alcohol consumption dependence may uncover disease mechanisms drive uncontrolled drinking identify novel pharmacogenetic targets facilitate therapeutic intervention treatment alcohol use disorder
growing population urban areas problem lacking space becoming prominent thus development underground space increasingly gained attention viable solution social aspects social behavior attitudes toward underground spaces could act facilitators inhibitors toward adoption underground spaces review present discuss major social parameters associated working underground spaces research overview identified three major themes pervade existing literature attitudes perception social behavior impact environmental attributes underground spaces yet also notice social cultural elements associated underground spaces remained largely unexplored previous research qualitative character extent outdated thus subsequently identified major unexplored themes present organized systematic research program holistic quantifiable understanding interaction social behavior underground spaces end discussing research program integrated disciplines including engineering design health published elsevier ltd
modified discrete cosine transform mdct modified discrete sine transform mdst employed subband transform coding schemes analysis synthesis filter banks based time domain aliasing cancellation princen bradley johnson defined two types mdct specifically evenly stacked oddly stacked analysis synthesis system new unified fast algorithm forward inverse mdct mdst computation evenly stacked system proposed based dct type dct dst type dst uses real arithmetic corresponding generalized signal flow graph regular structurally simple enables one compute alternate mdct mdst inverses general divisible length data sequence
circadian rhythms strongly associated affective disorders recent studies suggested utilization diurnal rodents model animal circadian rhythms related domains disorders previous work diurnal fat sand rat nile grass rat demonstrated short photoperiod conditions result behavioral changes including anxiety depression like behavior present study examined effect manipulating day length activity rhythms behavior diurnal degu animals housed weeks either short photoperiod neutral photoperiod evaluated sweet solution test forced swim test depression like behavior light dark box open field anxiety like behavior results indicate short photoperiod induced depression like behavior forced swim test sweet solution preference test anxiety like behavior open field compared animals maintained neutral photoperiod effects shown light dark box short photoperiod acclimated degu showed reduced total activity duration activity restricted light phase present study supports utilization diurnal rodents model circadian rhythms related affective change beyond possible diversity mechanisms underlying diurnality different animals evidences three different diurnal species fat sand rat grass nile rat degu shortening photoperiod results appearance anxiety depression like behaviors
data dependent operations ddos introduced moldovyan moldovyan mmm acns lncs springer heidelberg moldovyan int netw secur proceedings ccct vii proposed primitive suitable designing efficient ciphers simple key scheduling ddos solve problems arising due weaknesses key change process also ddo based ciphers provide better performance smaller hardware requirement implementation along eagle moldovyan eagle moldovyan minh int comput sci netw secur minh ijcsns aeuro broken vertical bar block ciphers designed minh advanced technologies communications atc block cipher type better terms applicability flexibility fast efficient wireless system well security known attack methods slide attack differential attack paper applying way related key attacks present possibility break cipher high probability propose related key amplified boomerang attack using differential characteristics round reduced requiring complexities data bytes memory computational time study considered first cryptographic result
background acute limb ischemia ali clinical entity high rate morbidity mortality despite advances variety management still criterion standard treatment goal study evaluate effect tirofiban use early month prognosis patients knee knee arterial thrombosis treated percutaneous thrombosuction within material methods data consecutive ali patients diagnosed popliteal infra popliteal arterial thrombosis underwent procedure within january september evaluated retrospectively patients separated groups according tirofiban usage results total patients mean age men included study atrial fibrillation hypertension frequent comorbidities patients thromboembolic events significantly higher rate distal embolization slow flow developed patients treated tirofiban procedure although major minor bleeding frequent tirofiban group rate minor bleeding statistically significant reverse embolic event ratio similar groups although higher rate amputation patients treated tirofiban difference significant conclusions adding tirofiban reduces angiographic thromboembolic complications usage tirofiban patients prone thromboembolic events may useful improving success procedure reasonable bleeding ratio
describe package realized julia programming language performs symbolic manipulations applied nonlinear evolution equations flows commutators objects tool employed perform contrived computations arising analysis local error operator splitting methods enabled proof convergence basic method asymptotical correctness defect based error estimator performance package illustrated several examples
proliferation offender reentry programs since passage second chance act including unprecedented expansion treatment services underserved rural areas review second chance act programming observation unmet mental health substance abuse needs justice settings contextualizes description middle tennessee rural reentry program bureau justice assistance funded intervention program targeted adult female male higher risk offenders dually diagnosed mental health substance abuse disorders evidence based cognitive behavioral change oriented therapeutic treatment offender outcome indicators recidivism relapse suggested program impact barriers implementing delivering evaluating reentry programming rural areas also identified orient discussion around evidence based demonstration replication
delanzomib cep reversible threonine boronic acid proteasome subunits inhibitor showed promising anti myeloma effects preclinical studies investigated single agent multicenter phase study patients relapsed refractory myeloma sixty one patients dose escalation expansion cohort received delanzomib days cycles received maximum tolerated dose mtd dose limiting toxicities dlts rash thrombocytopenia mtd prominent adverse events nausea vomiting anorexia fatigue pyrexia grade thrombocytopenia neutropenia occurred patients respectively peripheral neuropathy limited grades mtd patients stable disease four partial response median time progression ttp months across cohort based upon efficacy results development delanzomib myeloma discontinued
microsoft xbox sony playstation overlay achievement trophy systems onto video games though meta game reward systems growing popularity little research examined whether players notice use seek systems study game players participated focus groups discuss advantages disadvantages meta game reward systems participants described value meta game reward systems promoting different ways play games giving positive feedback game play boosting self esteem online offline social status participants discussed completionists garners want earn badges associated meta game though self determination theory subtheory cognitive evaluation theory suggest extrinsic rewards might harm players intrinsic motivation findings suggest players may see systems intrinsically motivating context implications rewards systems motivation video game habits internet gaming disorder discussed elsevier ltd rights reserved
complete computation integral homology generalized braid group associated arbitrary irreducible complex reflection group exceptional type order explicitly computed recursively defined differential resolution module using parallel computing also deduce general computation rational homology milnor fiber singularity attached reflection groups elsevier inc rights reserved
millions women united states abroad use oral contraceptive pills popular contraceptives common reversible birth control method united states wide variety pills available prescription oral contraceptives provide safe effective protection pregnancy offer several noncontraceptive benefits years advances laboratory knowledge gained epidemiologic data promoted development new contraceptive preparations generations oral contraceptives emerged time containing lower doses estrogens new novel progestins current review discusses clinical characteristics oral contraceptives emphasis basic pharmacology evolution various contraceptive formulations regimens
algorithm management joint stability midflexion change joint line considered primary cause although determines extension gap purpose study determine influence posterior condylar offsets pco defines flexion gap midflexion instability forty two knee joints patients included study patients undergoing navigated total knee arthroplasty due primary osteoarthritis knee changes pco determined navigation data gap tensioning device used determine width joint gap degrees degrees degrees degrees intraoperatively within range proximalization distalization influence stability midflexion contrast increase decrease pco led midflexion instability cases pco changed led midflexion instability seven cases whereas joint line displaced without measurable changes joint stability reconstruction posterior offset within tight range necessary avoid midflexion instability
conclusion bcl cell lymphoma involved process sensory cell degeneration aging cochleae objective determine molecular players age related hair cell degeneration study examined changes bcl expression different stages apoptotic necrotic death hair cells aging rat cochleae methods young months aging months fisher nhsd rats used thresholds auditory brainstem response abr measured determine auditory function immunolabeling performed determine expression bcl proteins sensory epithelium propidium iodide staining performed determine morphologic changes hair cell nuclei results aging rats exhibited significant elevation abr thresholds tested frequencies bcl immunoreactivity increased aging hair cells showing early signs apoptotic changes nuclei bcl expression increase also observed hair cells displaying early signs necrosis hair cell degenerative process advanced bcl immunoreactivity became reduced absent areas detectable nuclear staining present bcl immunoreactivity absent
type interferon mediated innate immunity flaviviridae hepatitis virus hcv dengue virus denv involves tlr rig like receptor rlr jak stat signal pathways asunaprevir newly developed hcv protease inhibitor hcv treatment whether asunaprevir activates innate immunity restrict viral infection unclear thus study investigates effect asunaprevir innate immunity influence hcv denv infection huh hep cells jfh infection model denv infection used analysis activity asunaprevir regulated innate immunity signal pathway assessed ifn promoter ifn stimulated responsive element isre reporter assays immunoblotting key signal proteins sirna mediated mavs trif knockdown cells performed assess effect asunaprevir regulated innate immunity hcv denv asunaprevir treatment activated isre ifn promoter luciferase activities signaling proteins jak stat mavs trif pathways huh cells asunaprevir mediated signaling activation decreased mavs knockdown cells importantly rna protein levels denv decreased asunaprevir treated huh hepg cells mavs knockdown cells restrictive effect asunaprevir hcv denv attenuated findings reveal unexpected activity asunaprevir activation mavs dependent innate immunity restrict hcv denv infection
explosive growth location enabled devices coupled increasing use internet services led increasing awareness importance usage geospatial information many applications mobile navigation apps often called maps use variety available data sources calculate predict travel time different modes paper evaluates pedestrian mode maps apps three major smartphone operating systems android ios windows phone demonstrate maps apps ios android windows phone pedestrian mode predict travel time without learning individual movement profile exemplify apps suffer specific data quality issue absence information location type pedestrian crossings finally illustrate learning movement profile individuals using predictive analytics models improve accuracy travel time estimation user personalization
purpose present study elucidate auxiliary effects application three dimensional computer aided design cad students creative design differences effects cad students different representational abilities ras unequal group pretest posttest quasi experiment design developed analyze students studying anonymous senior high school taipei city taiwan findings present study follows students ras achieved moderate positive correlation creative performance increased correlation ras functionality expressiveness constructs iconic representation construct ras cad evidently improved students particularly expressiveness functionality cad intervention students low ras performed similarly high ras terms novelty expressiveness elsevier ltd rights reserved
sleep thermal comfort one critical factors affecting sleep quality recent years research investigates ways products improve whole body thermal comfort attaches great importance local thermal comfort peripheral skin healthy sleep containing cycle position change considered regulate body temperature mattress design contacted human body provides direct impact sleep comfort twelve healthy participants general level bmi recruited day sleep monitoring simulated laboratory condition evaluate two different design mattresses one due body segment location mattress according position change sleep sleep position sleep quality data skin temperature examined statistical analysis study deduced relation mattress design dependent variables appraisement night sleep position change cycle skin temperature supine slightly stable regular less short phase body movement design due sleep position change furthermore design due position change contributed reduction sleep disturbance also promoted distal skin warming consequence indicated mattress design basis posture change conformed particularly demands local thermal comfort enhanced sleep quality published elsevier
describe presentation fertility sparing treatment young woman found steroid cell tumor otherwise specified nos spontaneous pregnancy delivery shortly surgery year old hispanic female presented hirsuitism virilization elevated androgen levels testosterone wrongly diagnosed polycystic ovarian syndrome four months later sought second opinion androgens follows testosterone level androstenedione dhea normal levels progesterone estradiol dhea transvaginal ultrasound solid appearing right ovarian mass underwent fertility sparing surgery laparoscopic right oophorectomy gross histological pathology confirmed benign steroid cell tumor nos rapid normalization androgens days surgery spontaneous resumption menses months later conceived despite using emergency contraception approximately months following surgery delivered healthy boy term without complication prompt evaluation androgen producing tumor performed testosterone levels greater pregnancy following removal rare tumor previously reported
objective jaw movement important mechanical factor prenatal development condylar cartilage mandible fetal jaw movement restriction shown cause deformity mandibular condyle hypothesized treatment affects expression mechanosensitive molecules namely indian hedgehog ihh parathyroid hormone related protein pthrp condyle experimental methods restrained jaw movement suturing jaw mouse embryos allowed develop using exo utero system analyzed immunohistochemistry situ hybridization methods results morphological histomorphometric immunohistochemical study showed mandibular condylar cartilage reduced deformed volume total cell numbers condylar cartilage also reduced number distribution bromo deoxyuridine positive cells ihh positive cells mesenchymal pre hypertrophic zones significantly correspondingly decreased sutured group using situ hybridization reduced expression ihh pthrp related receptors observed condylar cartilage sutured embryos conclusions results revealed altered mechanical stress induced prenatal jaw movement restriction decreased proliferating cells amount cartilage altered expression ihh pthrp suggesting ihh act mechanotransduction mediators development mandibular condylar cartilage elsevier ltd rights reserved
introduction use frax without inclusion bone mineral density frax bmi may useful clinical practice identify patients high risk fracture inform treatment decisions usefulness debated aim study evaluate agreement risk fracture calculated frax without bone mineral density bmd patients methods cross sectional study conducted women years without treatment concordance probability fracture assessed concordance correlation coefficient ccc bland altman method kappa index used evaluate agreement results difference risks major osteoporosis fracture mofr hip fracture risk hfr agreement mofr hfr frax scores good ccc ccc respectively correlation bmd femoral neck fracture risk calculated fraxbmi moderate mofr hfr agreement recommendations treatment kappa conclusions good agreement risk fracture obtained suggests frax bmi allows provide estimate risk cases elsevier espana rights reserved
introduction proposed concept training internet things technology within framework speciality telecommunications radio engineering given practice organization sequencing courses students allows teach design entire system using internet things main part internet things technologies require wide range knowledge skills building unified data collection processing forming control signals feedback circuit single step study practical application allows learn build system programming languages iot technology tool lets collaborate sensors basic microcomputers perform data processing cloud services work control signals stage construction iot systems used various programming languages preference given support open operating systems conclusions feature course sequence practical value content final result orientation
age race sex linked social cognitive performance among healthy individuals whether similar effects evident schizophrenia unknown data individuals schizophrenia schizoaffective disorder healthy controls used examine relations demographic factors performance across multiple domains measures social cognition sex related performance domain older age related poorer emotion recognition dynamic stimuli patients controls patients older age also associated better abilities decipher hints caucasian patients controls performed better african american individuals emotion recognition mental state attribution tasks use caucasian individuals visual stimuli findings suggest rather limited influences demographic factors demonstrate normative age race effects among patients findings also highlight important methodological considerations measurement social cognition
stormwater runoff poses serious environmental problems public health issues rwanda tropical country increasingly suffering severe floods landslides soil erosion water pollution using wetspa extension model study assessed changes rainfall runoff depth rwanda response precipitation land use changes results show rwanda experienced significant conversion natural forest grassland cropland built areas period forest grassland covers lost respectively cropland built areas increased respectively according estimates land use change effect resulted national mean runoff depth increase year although precipitation change affected inter annual fluctuation runoff long term trend runoff dominated land use change top five districts experienced annual runoff depth increase year rubavu nyabihu ngororero gakenke musanze annual runoff depths increased rate year past years due severe deforestation ranging cropland expansion ranging areas require high priority runoff control using terracing croplands rainwater harvesting systems dam reservoirs percolation tanks storage tanks etc wet season runoff three times higher dry season runoff rwanda appropriate rainwater management reservation could provide valuable irrigation water dry season drought years late rainfall onsets early rainfall cessations estimated reservation runoff wet season could meet cropland irrigation water gap dry season
purpose study assess seasonality associated common non communicable diseases ncds general finnish population global seasonality score gss used measure magnitude seasonality participants addition reported extent seasonal variations mood behavior experienced problem regression models odds ratios adopted analyze associations adjusted range covariates seventy percent participants seasonal variations sleep duration social activity mood energy level forty percent weight appetite angina pectoris depression significantly associated seasonality throughout analysis hypertension high cholesterol levels diabetes rheumatoid joint diseases depressive psychological illnesses significantly associated experiencing problem due seasonal variations increase gss seasonal affective disorder subsyndromal form occurrence seasonal variations mood behavior certain common ncds warrants future research insights etiology potentially shared pathways mechanisms action elsevier ireland ltd rights reserved
present gpurdma gpu side library performing remote direct memory accesses rdma across network directly gpu kernels library executes code cpu directly accessing host channel adapter hca infiniband hardware control data slow single thread gpu performance intricacies gpu network adapter interaction pose significant challenge describe several design options analyze performance implications detail achieve sec one way communication latency gbit sec transfer bandwidth messages larger nvidia gpus across network moreover gpurdma outperforms cpu rdma smaller packets ranging bytes factor thanks greater parallelism transfer requests enabled highly parallel gpu hardware use gpurdma implement subset global address space programming interface gpi point point asynchronous rdma messaging demonstrate preliminary results using two simple applications ping pong multi matrix vector product constant matrix multiple vectors running two different machines connected infiniband basic ping pong implementation achieves higher performance baseline using gpi improved ping pong implementation per threadblock communication overlap enables improvement multi matrix vector product faster thanks higher throughput small messages ability keep matrix fast gpu shared memory receiving new inputs gpurdma prototype yet suitable production systems due hardware constraints current generation nvidia gpus discuss detail however results highlight great potential gpu side native networking encourage research toward scalable high performance heterogeneous networking infrastructure
computer programmers dyslexia found range academic professional scenarios dyslexia may effect computer programmer degrading expected results collaborative software development people may perform better using visual programming languages however need understand programmers dyslexia experience order able come possible solutions conducted analysis existing literature survey dyslexia programming paper reports preliminary results based data gathered far key characteristics needs group aim defining profile computer programmers dyslexia
background stress defined state threatened perceived threatened homeostasis broad spectrum extrinsic intrinsic real perceived stressful stimuli called stressors activates highly conserved system stress system adjusts homeostasis central peripheral neuroendocrine responses inadequate excessive prolonged adaptive responses stress may underlie pathogenesis several disease states prevalent modern societies development severity conditions primarily depend genetic vulnerability individual exposure adverse environmental factors timing stressful event given prenatal life infancy childhood adolescence critical periods characterized increased vulnerability stressors materials methods conducted systematic review original articles reviews published medline june search terms childhood stress pediatric stress stress disorders stress management results review discuss historical neuroendocrine aspects stress present representative examples paediatric stress system disorders early life adversity obesity bullying also discuss adverse impact socio economic crisis childhood health tremendous progress epigenetics enabled deeper understanding molecular mechanisms underlying paediatric stress related disorders conclusions need early successful stress management techniques decrease incidence paediatric stress related diseases well prevent development several pathologic conditions adolescence adulthood imperative
three dimensional spatio temporal analog signal processing scheme presented selective removal dish interference noise focal plane array fpa received signals method exploits specific geometrical properties spatio temporal frequency spectrum fpa signals perform filtering operation infinite impulse response iir filter cone shaped filter passband spatio temporal frequency space employed extract spectra desired fpa signals rejecting spectral components undesired dish interference coupled noise front end electronics proof concept example provided considering filtering operation spatio temporal frequency domain
aimdementia cognitive impairment important public health challenges rapidly aging country present study aimed explore protective factors cognitive decline among community dwelling middle aged older people health social lifestyle perspectives methodsdata social environment biomarkers aging study population based cohort study taiwan retrieved study overall participants intact baseline cognitive function measured short portable mental status questionnaire enrolled followed six years increasing score short portable mental status questionnaire observational period referred cognitive function decline associated factors cognitive decline identified logistic regression model resultsamong participants experienced cognitive decline study period crude logistic regression showed women odds ratio confidence interval low educational level low mastery associated cognitive decline daily consumption vegetables fruits marginal association fully adjusted logistic regression analysis old age women low educational level low sense mastery independent predictors cognitive decline participants two modifiable factors mastery daily consumptions vegetables fruits lower risk cognitive decline compared without protective factor conclusionsparticipants better educational level better personal mastery consumption fruits vegetables less likely experience cognitive decline intervention study combining features carried promote better cognitive health communities geriatr gerontol int suppl
method system identification force transducers oscillation force developed method force transducers equipped additional top mass excited facility sine mechanism particle swarm optimization pso algorithm employed identify parameters derived mathematical models improving convergence speed pso exponential transformation introduced fitness function subsequently numerical simulations experiments carried consistent results demonstrate identification method proposed investigation feasible efficient estimating transfer functions sinusoidal force calibration measurements
requirements engineering produces specifications needs conditions meet software product specifications may vague ungrounded relation requirements observations derived may unclear documented furthermore stakeholders may influenced solutions existing software without knowing actually suit software developed cope issues important understand complete task designing software system support task thus developed method called grounded requirements engineering gre leverages grounded theory method observe analyze processes user activities real world gre iterative process consisting two steps first grounded theory methods used analyze user experiments interviews second resulting abstract descriptions user behavior transferred use cases gre produces comprehensible grounded requirements software system built requirements traceable back origins paper provide elaborate description gre method illustrate applying derive requirements interactive software tool model merging development tool served basis design gre well test elsevier inc rights reserved
efficient leaf water supply fundamental assimilation processes tree growth renovating architecture xylem transport system requires increasing carbon investment growing taller deficiency carbon availability may result increasing hydraulic constraints water flow therefore plants need coordinate carbon assimilation biomass allocation guarantee efficient safe long distance transport system tested hypothesis reduced branch elongation rates together carbon saving adjustments xylem anatomy hydraulically compensate reduction biomass allocation xylem measured leaf biomass hydraulic anatomical properties wood segments along main axis branches slow growing fast growing fraxinus ornus trees branches trees five times slower branch elongation rate year produced higher leaf biomass thinner xylem rings fewer larger vessels xylem safety psi approximate mpa slower elongation rate coupled thinner annual rings larger vessels allows reduction carbon costs associated growth maintaining similar leaf specific conductivity xylem safety
background food allergy growing health problem limited treatment options investigation immunologic pathways underlying allergic sensitization foods humans greatly constrained limited availability intestinal tissue gut resident immune cells although mouse models offered insights pathways food sensitization differences rodent human immune physiology limit extension findings understanding human disease objective sought develop strategy generation mice humanized adaptive immune systems complete tissue engraftment human mast cells competent mount specific ige mediated responses drive systemic anaphylaxis ingestion challenge methods nonobese diabetic severe combined immunodeficient mice lacking cytokine receptor common gamma chain gamma carrying human stem cell factor transgene engrafted human hematopoietic stem cells impact peanut feeding ige neutralization development immune responses mast cell homeostasis anaphylactic food allergy assessed animals results humanized nonobese diabetic severe combined immunodeficient common gamma chain deficient stem cell factor hunsg mice exhibited robust engraftment functional human lymphocytes human mast cells found significant numbers tissues including intestinal mucosa following gavage feeding mounted specific antibody responses including specific ige enterally challenged exhibited mast cell mediated systemic anaphylaxis indicated hypothermia increases plasma tryptase levels anti ige omalizumab treatment ablated anaphylactic response conclusions hunsg mice provide novel tool studying food allergy ige mediated anaphylaxis
purpose study nas undertaken determine community screening program designed overcome key barriers lack awareness cost program ease access care could successfully impact african american males knowledge attitudes behaviors regarding prostate cancer screening focus report knowledge date reported studies examine differences knowledge prescreening baseline postintervention level minority participants patients methods total men enrolled study month period prostate screening education offered new service existing senior health clinic addition mass screenings offered approximately monthly various locations community including senior community centers senior apartment complexes public housing projects screening included digital rectal examination prostate specific antigen test brief questionnaire administered client intake pretest repeated education screening participation posttest test items targeted three constructs etiology risk status clinical factors results largest difference pretest scores racial groups resulted clinical factor knowledge african american men significantly less likely caucasian men correctly identify early symptoms prostate cancer acid basic components prostate checkup although scores initially significantly lower african american participants differences evident program involvement significant increase knowledge level men comparing pretest posttest scores significant improvement noted test item exception one key item even participation program african american men still likely believe pain first symptom prostate cancer discussion item item analysis revealed one test item program participation correct knowledge african american men still likely believe pain first symptom would alert presence cancer screening program included information printed oral content emphasized importance routine screening detect cancer early stage men would experience symptoms reported study examined knowledge documented similar findings respect understanding symptomology findings used direct guide educational component future screening programs hope target african american men
advanced human augmentation provides human centred perspective technology design builds upon earlier technological concepts ubiquitous computing wearable computing augmented virtual mixed realities autonomous systems ambient intelligence tutorial contemplates advanced human augmentation industrial work context considers requirements future augmented superworker prerequisites advanced augmentation tutorial anticipated support design new augmenting solutions current human centred design practices reconsidered enhanced new directions
israeli worldview places great significance childbearing could create emotional ethical difficulties women coping fertility issues addition treatments study examined relations coping strategies level religiosity women undergoing infertility treatment statistically significant relations found problem solving coping style religious observance religious beliefs inverse correlation found emotional coping style religious beliefs health professionals recognize patient coping styles understand patient religious belief system part ongoing fertility treatment
article examines importance able read body language signals business negotiations observing physical body changes gestures lead less realistic impression opponent feelings mood thoughts expectations intentions changes important aspects non verbal body language posture clothing accessories gestures eye contact facial expressions smile voice tone laughter eye contact eye signs distance participants conversation touch clap dance physiological response sweating palms forehead paleness acute facial neck redness etc non verbal communication signs words body language signals conscious either natural pretended others communicated environment unintentionally immediate instant instinctive response received information without thinking body language signals business negotiations important several aspects reveal person opponent physical emotional state well change complement reinforce weaken spoken words enable read non verbal communication signs determine whether said true less accurately
laser zona drilling lzd required step many embryonic surgical procedures example assisted hatching preimplantation genetic diagnosis lzd involves ablation zona pellucida using laser minimizing potentially harmful thermal effects critical internal cell structures objective develop method automation optimization multipulse lzd applied cleavage stage embryos methods two stage optimization used first stage uses computer vision algorithms identify embryonic structures determines optimal ablation zone farthest away critical structures blastomeres second stage combines genetic algorithm previously reported thermal analysis lzd optimize combination laser pulse locations pulse durations goal minimize peak temperature experienced blastomeres creating desired opening results proof concept proposed lzd automation optimization method demonstrated experiments mouse embryos positive results adequately sized openings created conclusion automation lzd feasible viable step toward automation embryo biopsy procedures significance lzd common delicate procedure performed human operators using subjective methods gauge proper lzd procedure automation lzd removes human error increase success rate lzd although proposed methods developed cleavage stage embryos methods may applied types lzd procedures embryos different developmental stages nonembryonic cells
present study aimed screen several differentially expressed genes degs differentially expressed micrornas mirnas two types mesenchymal stem cell msc differentiation bone morphogenetic protein bmp dexamethasone used induce mscs towards osteoblastic differentiation adipocytic differentiation test bioconductor bioinformatics software tool used screen degs differentially expressed mirnas two samples subsequent gene ontology pathway analyses degs performed using kyoto encyclopedia genes genomes databases respectively potential target genes screened mirnas predicted using targetscan database addition interaction network degs mirnas constructed numerous degs mirnas screened osteoblastic adipocytic differentiation mscs important pathways glutathione metabolism pathogenic escherichia coli infection parkinson disease terms including cytoskeletal protein binding phospholipase inhibitor activity enriched screened degs mscs undergoing osteogenic differentiation adipocytic differentiation mirnas including mirna mir mir degs including neuronal growth regulator negr phosphatidic acid phosphatase ppapb platelet derived growth factor receptor alpha pdgfra interleukin signal transducer ilst sortilin sort demonstrated involved osteoblastic differentiation addition downregulated mirnas including mir mir mir upregulated mir upregulated degs including enabled homolog enah polypeptide acetylgalactosaminyltransferase acyl coa synthetase long chain family member downregulated repulsive guidance molecule family member semaphorin semaa demonstrated involved adipocytic differentiation results present study suggested mirnas mir mir degs negr ppapb pdgfra ilst sort may serve pivotal functions osteoblastic differentiation mscs whereas mir also involved osteoblast differentiation four targets including negr mir mir enah may crucial roles adipocytic differentiation mscs
optic perineuritis uncommon inflammatory disorder optic sheath causes visual loss eye pain case reports optic perineuritis associated granulomatosis polyangiitis herein report case year old male granulomatosis polyangiitis presented headache blurred vision right eye diplopia numbness right forehead brain magnetic resonance images mri findings revealed hypertrophic pachymeningitis refractory optic perineuritis manageable means weekly methotrexate mycophenolate mofetil combination therapy methotrexate mycophenolate mofetil intravenous cyclophosphamide rituximab azathioprine cyclosporine individually
introduction cognitive behavioural stress management programs studied many countries many reports shown beyond doubt efficacy reduce perceived stress anxiety symptoms improve quality life patients considering large number people could benefit programs unable reach self help programs offered first presented books bibliotherapy programs became enriched computing digital supports regrettably many programs stress management based cognitive behavioural therapy cbt face face digital support little evaluated france knowledge seren ctif program first french language self help program stress management proposed digital support aim study led feasibility study program patients responding diagnosis adjustment disorder anxiety according dsm criteria methods program includes weekly sessions patient follows unit web site benefits minimal contact medical member staff every session right first session usb key supplied patient containing videos audio files self help book portfolio form guide log books exercises realized sessions session program patient encouraged practice minutes exercises days per week program feasibility assessed accordance standard satisfaction scale anxiety symptomatology quantified thanks spielberger state trait anxiety inventory stai results scheduled weeks good results found terms acceptability attractiveness average score satisfaction survey least equal item mean score stai state decreased following intervention discussion seren ctif program may useful within framework psychoeducative approach could also advised people suffering anxiety related stress soon program tested patients usual care suffering adjustment disorder anxiety order precisely assess benefits encephale paris
purpose paper aims investigate ways gender influences entrepreneurial motivations barriers brazilian tourism sector economic process tourism entrepreneurship widely spread brazil tourism development programs promoting strategy empower women however limited research exists gender roles influence entrepreneurial ideals nationwide study aims provide contemporary insight tourism entrepreneurs brazil situated within current entrepreneurship theorizing questioning complexity caused gender roles influence entrepreneurial conceptualizations constitute motivations barriers design methodology approach study uses online questionnaires aimed first time large variety tourism sub sectors brazil nation wide scope questionnaires produce knowledge motivates constrains brazilian tourism entrepreneurs gender lens quantitative analysis using spss statistical software tests statistical significance results complemented integration feminist economic theories analytical framework findings current study findings highlight invisibility gender workings majority participants conceive gender playing role entrepreneurial experience entrepreneurial motivations barriers show departure past literature fact similar numbers male female tourism entrepreneurs perceive networking significant entrepreneurial barrier interesting findings prompt alternative conceptualizations discourses surrounding women involvement tourism entrepreneurship originality value study consists original contribution knowledge tourism entrepreneurship brazil first time empirical study made nation wide scale regarding role gender brazilian tourism entrepreneurs motivations constraints
background patients medication overuse headache suffer chronic headache often psychiatric comorbidities anxiety depression mechanisms underlying comorbidities unclear amygdala likely involved pathogenesis investigate mechanisms underlying comorbidities used elevated plus maze open field tests assess anxiety like behavior rats chronically treated analgesics measured electrical properties neurons amygdala examined cortical spreading depression csd evoked expression fos trigeminal nucleus caudalis tnc amygdala rats chronically treated analgesics csd analog aura evokes fos expression tnc rodents suggesting trigeminal nociception considered model migraine results increased anxiety like behavior seen elevated plus maze open field tests model medication overuse produced male rats chronic treatment aspirin acetaminophen time spent open arms maze aspirin acetaminophen treated rats respectively significantly shorter spent saline treated vehicle control rats chronic treatment analgesics increased excitability neurons central nucleus amygdala indicated negative threshold action potential generation aspirin treated acetaminophen treated saline treated rats chronic treatment analgesics increased csd evoked expression fos tnc amygdala fos immunoreactive neurons per slide amygdala rats treated aspirin neurons per slide rats treated acetaminophen neurons per slide saline treated control rats conclusions chronic treatment analgesics increase excitability neurons amygdala could underlie anxiety seen patients medication overuse headache
technique designing square root domain elliptic filters simulate operation corresponding ladder prototypes introduced paper achieved manipulating equations describe operation differentiation way lossless integrator weighted summation blocks needed derived signal flow graph sfg transposed corresponding one square root domain using appropriate set operators order preserve linear operation whole filter order demonstrate validity proposed technique third order elliptic lowpass filter simulated behavior evaluated using hspice simulator
present study investigated role authoritarianism association actual proportion ethnic minorities objective diversity within neighborhood majority members subjective perception thereof perceived diversity additionally tested authoritarianism affects direct indirect relationships objective diversity outgroup threat anxiety mistrust analyses nationally stratified sample dutch citizens without migration background different neighborhoods showed higher levels authoritarianism dual effect relationship objective diversity negativity towards outgroups particular authoritarianism boosts indirect relationship objective diversity greater outgroup negativity perceived diversity curbs direct association objective diversity reduced outgroup negativity findings shed light majority members different levels authoritarianism differentially perceive diversity neighborhood relates responses ethnic minorities
psychological warmth serves fundamental dimension human social cognition impressions strangers appraisals groups assessments warmth coldness comprise elemental building block social perception using embodiment guiding framework research demonstrated perceptions others along warm cold dimension elicited sensory experiences physical warmth show effects kind also triggered mentally simulating physical temperature certain theoretically important imagery conditions specifically impressions target impacted imagined warmth coldness thinking holding cup hot iced coffee event simulated egocentric first person perspective effect emerged allocentric third person orientation adopted finding underscores functional nature mental simulation identifies spatial visual perspective critical boundary condition embodied cognition elsevier inc rights reserved
floods natural disasters cause economic damage global level therefore flood monitoring damage estimation important population authorities insurance companies paper proposes original solution based hybrid network complex image processing problem first novelty multilevel system two components terrestrial aerial proposed designed authors support image acquisition delimited region terrestrial component contains ground control station coordinator distance communicates via internet ground data terminals fixed nodes network data acquisition communication aerial component contains mobile nodesfixed wing type uavs order evaluate flood damage two tasks must accomplished network area coverage image processing second novelty paper consists texture analysis deep neural network taking account new criteria feature selection patch classification color spatial information extracted chromatic occurrence matrix mass fractal dimension used well finally experimental results real mission demonstrate validity proposed methodologies performances algorithms
background systematically evaluate therapeutic effect electrical stimulation overactive bladder method retrieved information searching databases pubmed cbm disc cochrane library science direct elsevier publishers springer publishers march looked randomized controlled trials studied treatment subject headings keywords using literature searches manual retrieval references included studies reviewed literature screened independently two investigators according inclusion exclusion criteria extracting data evaluating quality meta analysis undertaken revman results ten randomized controlled trials involving patients included meta analysis results demonstrated better effects improving bladder compliance reducing residual urine decreasing frequency enuresis patients compared control group elicited significantly better effects diminishing maximum detrusor pressure children controls significant difference maximum detrusor pressure adults controls therapeutic effect combined therapies increasing maximum bladder capacity better compared therapies alone significant difference noted alone therapies alone conclusions based current evidence certain effects obs severe adverse reactions observed safe efficacious worthy clinical use
paper present finite pointset method fpm numerical simulation free surface flow around ship calm water lagrangian meshless particle scheme applied projection method incompressible governing equations requires solution poisson problems time step moving least squares mls interpolants used spatial derivatives order discretize poisson equation pressure dirichlet condition free surface flow meshless structure meanwhile additional problem periodic particle locations redistribution present approach still handled mls interpolants proposed fpm technique problems associated free surface flow around ship circumvented verification numerical modeling made using wigley hull validity proposed methodology examined comparing detail wave profile wave making resistance series model results demonstrate fpm able perform efficient stable simulations free surface flow around ship
zwitterionic peptides anchored conducting polymer citrate doped poly ethylenedioxythiophene pedot via nickel cation coordination obtained peptide modified pedot excellent antifouling ability good conductivity used immobilization dna probe construct electrochemical biosensor breast cancer marker brca dna biosensor highly sensitive detection limit selective able detect brca human plasma satisfying accuracy low fouling marriage antifouling biocompatible peptides conducting polymers opened new avenue construct electrochemical biosensors capable assaying targets complex biological media high sensitivity without biofouling
objectives mutations calr calreticulin discovered jak janus kinase mpl myeloproliferative leukemia protein wild type patients philadelphia negative myeloproliferative neoplasm mpns evaluate performance monoclonal antibody immunohistochemical detection calr mutations methods computerized archival search performed cases non chronic myeloid leukemia cml mpns available calr jak mutational analysis data bone marrow biopsy specimens stained monoclonal antibody cal percentage stained megakwyocytes calculated select cases double immunofluorescence staining done cal following myeloperoxidase glycophorin results studied bone marrow biopsy specimens non cml mpns primal myelofibrosis essential thrombocythemia post polycythemia vera myelofibrosis patients eight bone marrow biopsy specimens patients mutant calr showed strong cytoplasmic staining megakaryocytes range median cal antibody double immunofluorescence staining small mononuclear cells seen calr mutant cases revealed myeloid blasts conclusions immunohistochemistry routinely processed bone marrow biopsy specimens mutated calr feasible accurately identifies mutated cases including rare cases additional driver mutations
purpose transcatheter aortic valve implantation tavi associated large incidence ischemic events whose sources still unclear fact sub acute complications directly related severity calcification host tissues catheter manipulation implant potential cause could local flow perturbations introduced implantation approach resulting thrombo embolic consequences particular contrary surgical approach tavi preserves presence native leaflets expanded paravalvular space inside valsalva sinuses purpose study verify configuration determine hemodynamic variations may promote blood cell aggregation thrombus formation methods study performed vitro idealized models patient anatomy tavi reproducing range physiological operating conditions pulse duplicator fluid dynamics valsalva sinuses analyzed characterized using phase resolved particle image velocimetry results comparison flow downstream valve clearly indicated major alterations fluid mechanics tavi characterized unphysiological conditions associated extended stagnation zones base sinuses conclusion prolonged stasis observed valsalva sinuses configuration modelling presence transcatheter aortic valves provides fluid dynamic environment favourable red blood cell aggregation thrombus formation may justify recently reported thromboembolic ischemic events suggests adoption anticoagulation therapies following tavi caution patients selection authors published elsevier ltd
sliding resistance main cable biggest concern designing multispan suspension bridges paper presents study layout form sliding resistance stability main cable double cable multispan suspension bridge proposes top cable bottom cable layout based analytical formulas calculating sliding resistance coefficient double cable derived formulas verified finite element models fems results showed good agreement effects major design parameters sliding resistance main cable studied analysis shows top cable bottom cable layout effectively improve sliding resistance main cable bottom cable loaded span top cable unloaded span control antisliding design double cable sliding resistance main cable decreases along increase ratio tower stiffness cable stiffness influence sag span ratio sliding resistance main cable related tower stiffness sliding resistance main cable increases increase ratio dead load live load american society civil engineers
background angiotensin receptor antagonists proposed replacement therapy occurrence either angiotensin converting enzyme ace inhibitor induced angioedema cough however recent studies indicate angioedema associated elevated bradykinin levels small fraction patients treated angiotensin receptor blockers suggesting common pathophysiological mechanism date standard treatment angiotensin receptor blocker induced angioedema exist methods present case series patients admitted hospital due angioedema induced angiotensin receptor blocker patients either treated either icatibant prednisolone hydrogen succinate clemastine patient groups compared untreated patient cohort patients previously diagnosed essential hypertonia results icatibant effective therapy angiotensin receptor blocker induced angioedema full symptom recovery achieved hours whereas symptom remission occurred within hours patients treated solu decortin prednisolone clemastine untreated patients respectively recovery time icatibant similar described previous studies regarding therapeutic efficacy icatibant treatment hereditary angioedema patients suffering angiotensin converting enzyme inhibitor induced angioedema conclusions icatibant safe effective substance treatment angiotensin receptor blocker induced angioedema although pathophysiology angiotensin receptor blocker induced angioedema remains unclear appears associated bradykinin pathway
alcohol exposure pregnancy cause adverse effects fetus interferes fetal development leading later physical mental impairment common clinical tool determine fetal alcohol exposure maternal self reporting however objective useful method based use biomarkers biological specimens alone combination maternal self reporting review reports clinically relevant biomarkers detection prenatal alcohol exposure pae systematic search performed ensure proper overview existing literature studies selected give overview clinically relevant neonatal maternal biomarkers direct biomarkers fatty acid ethyl esters faees ethyl glucuronide etg ethyl sulfate phosphatidylethanol peth found appropriate biomarkers relation detection pae review biomarker clinical context compared advantages disadvantages biomarker relation window detectability ease collection ease cost analysis biomarker biomarkers peth faees etg found applicable detection even low levels alcohol exposure meconium accessible matrix determination faees etg blood accessible matrix determination peth
paper presents new linear velocity estimator based unscented kalman filter making use image information aided inertial measurements proposed technique independent scale factor case planar observed scene require priori knowledge scene image moments virtual objects sets classical image features corners collected online employed sole correcting information fed back estimator experimental results performed quadrotor equipped fisheye camera highlight potential proposed approach
article explains demonstrates evaluates chaum protocol detecting man middle mitm text messaging network communications mitm attacks pose serious risks many network communications networks often mitigate risks robust protocols tls assume type public key infrastructure provides mechanism authenticated exchange public keys contrast chaum protocol aims detect mitm minimal assumptions technology particular without assuming authenticated exchange public keys chaum assumes eavesdropper sound like communicants eavesdropper fabricate sensible conversations using encryption function one way function chaum protocol works three phases phase communicants exchange public keys phase communicant generates random string first communicant cryptographically commits string sends string communicant receiving string phase iii using four different scenarios communicants verify possesses two strings protocol forces mitm cause communicants possess different pairs strings text messaging scenario similar forced latency protocol proposed wilcox hearn article implements experimentally demonstrates effectiveness third scenario uses timing detect mitm text messaging even assuming mitm send messages without network latency protocol forces mitm cause delays noticeable communicants article first explain demonstrate evaluate chaum protocol chaum described abandoned nearly inscrutable patent application
using gpus general purpose processors revolutionized parallel computing providing large growing set algorithms massive data parallelization desktop machines obstacle widespread adoption however difficulty programming low level control hardware required achieve good performance paper proposes programming approach safegpu aims make gpu data parallel operations accessible high level libraries object oriented languages maintaining performance benefits lower level code approach provides data parallel operations collections chained combined express compound computations data synchronization device management handled automatically also integrates design contract methodology increases confidence functional program correctness embedding executable specifications program text present prototype safegpu eiffel show leads modular concise code accessible gpgpu non experts still providing performance comparable hand written cuda code also describe first steps towards porting highlighting challenges solutions insights implementing approach different managed languages finally show runtime contract checking becomes feasible safegpu contracts executed gpu elsevier ltd rights reserved
objectives testosterone deficit syndrome tds clinical biochemical entity characterized low testosterone levels androgenic deprivation clinic cause decrease quality life however today doubts diagnosis therapeutic management methods bibliographic review using medline database detailed presentation one clinical case results testosterone deficit syndrome associated metabolic syndrome visceral obesity arterial hypertension diabetes mellitus dyslipemia currently performance tds screening males age years discussion propose diagnostic therapeutic algorithm management tds erectile dysfunction conclusions treatment erectile dysfunction associated late start hypogonadism follows steps tha generic cases erectile dysfunction
body image concerns common among people living hiv among adults hiv body image concerns shown related risky sexual behaviors little research conducted among youth living hiv ylwh current study examined predictors including body image sexual risk behaviors among ylwh adolescents single clinic age range years male african american completed computerized self report survey assess demographic behavioral body image domains demographic clinical data abstracted medical record logistic regression analyses assessed associations risk factors risky sexual behaviors results indicated ylwh reported less favorable body image perceptions sexual partners less likely use condoms last sexual encounter ylwh six sexual partners likely use drugs alcohol last sexual encounter belief hiv medications changed body physically history hiv related complications undetectable viral load recent clinical laboratory draw high school diploma equivalent independently associated disclosure participant hiv status romantic sexual partner findings suggest body image perceptions may influence risky sexual behavior ylwh study warranted understand intervene upon relationship improve individual public health outcomes
sclerostin antibody scl increases osteoblast activity part increasing modeling based bone formation previously quiescent surfaces histomorphometric studies suggested might occur conversion bone lining cells active osteoblasts however direct data demonstrating scl induced conversion lining cells active osteoblasts lacking used vivo lineage tracing determine scl promotes conversion lining cells osteoblasts periosteal endocortical bone surfaces mice two independent tamoxifen inducible lineage tracing strategies used label mature osteoblasts progeny using dmp osteocalcin promoters prolonged chase period majority labeled cells bone surfaces assumed thin quiescent morphology mice treated either vehicle scl twice course subsequent week euthanization marked cells enumerated thickness quantified proliferation apoptosis examined scl led significant increase average thickness labeled cells periosteal endocortical bone surfaces consistent osteoblast activation scl induce proliferation labeled cells scl regulate apoptosis labeled cells therefore direct reactivation quiescent bone lining cells contributes acute increase osteoblast numbers scl treatment mice american society bone mineral research
two methods compared determination inertial properties small fixed wing manned aerial vehicle first method uses standard single degree freedom pendulum method second method implements novel potentially easier degrees freedom pendulum method yields entire inertia tensor single swing test methods using system identification pendulum motion estimate inertial properties substantial corrections applied experimental results corrections caused acceleration pendulum immersed surrounding air also called added mass effect found methods presented literature determine corrections full scale aircraft give correct results small scale manned aerial vehicle consideration feasible cost effective method generate corrections utilise swing tests geometrically similar object known inertial properties also found corrections unique respect experimental methods several benchmarking methods including innovative use static dynamic wind tunnel test data give high confidence results
article presents results observations selected fluxes radiation balance north western spitsbergen years measurements taken angstrom lesund area kaffioyra different surface types occurring polar zone moraine tundra snow ice substantial differences radiation balance among various types surface observed observations carried summer seasons area kaffioyra demonstrated considerable reflection solar radiation waldemar glacier albedo resulted smaller solar energy net income polar day diurnal course components radiation balance apparently related solar elevation angle sun low horizon radiation balance became negative especially glacier diurnal annual multi annual variations radiation balance significant influence functioning environment polar conditions
paper new first order pass filter based single differential input buffered transconductance amplifier dbta active element single capacitor single resistor presented proposed circuit works voltage transadmittance mode simultaneously fully cascadable due high impendance voltage input low high output impedance voltage current outputs respectively behavior filter verified spice simulations using commercially available ics opa texas instruments confirm theoretical analyze
purpose purpose paper establish adaptive assembly realize adaptive changing models improve flexibility reliability assembly change three dimensional computer aided design cad assembly changing process two practical problems one delivering parameters information smoothly one easily destroy assembly structure design methodology approach paper establishes associated parameters design structure matrix related parts predicts possible propagation paths parameters based predicted path structured storage made affected parameters tolerance range calculation relations study combines structured path information constrained assemblies build adaptive assembly proposes adaptive change algorithm assembly changing discusses extendibility adaptive assembly findings approach would improve flexibility reliability assembly change applied different cad platform practical implications examples illustrate construction adaptive behavior assembly verify feasibility reasonability adaptive assembly practical application originality value adaptive assembly model proposed paper original method assembly change compared methods good results obtained
work new kerwin huelsman newcomb khn biquads employing current controlled current conveyors ccciis voltage mode well current mode presented parameters proposed circuits electronically controlled thanks tunability properties ccciis circuit derived previously reported one modifying summing circuit replacing current conveyors cciis resistors input terminals ccciis band circuit derived adjoint graph signal flow graph corresponding classical khn circuit circuit multi input single output universal filter offers main advantages circuits well classical khn circuit addition three basic filter responses also allow realization notch allpass responses
pointwise intensity based algorithms popular algorithms dynamic laser speckle measurement physical biological activity output measurement two dimensional map qualitatively separates regions higher lower activity paper proposed filtering activity maps enhance visualization enable quantitative determination activity time scales first step proved severe spatial fluctuations within map resemble signal dependent noise second step illustrated implementation proposed idea applying filters non normalized normalized activity estimates derived synthetic experimental data statistical behavior estimates analyzed choose filter parameters substantial narrowing probability density functions estimates achieved filtering filtered maps exhibit improved contrast allowed quantitative description activity
whitewater parks wwps increasingly popular recreational amenities effects wwps fish habitat passage poorly understood study investigated use two dimensional model compared three dimensional hydrodynamic model flow assessing effects wwps fish habitat primary aims study examine utility modelling versus modelling hydraulically complex wwp compare modelled habitat quality resident fishes actual fish abundance biomass generated field sampling surveys two reaches wadeable river colorado modelled natural reach reach containing wwp habitat suitability analysis juvenile adult brown trout juvenile adult rainbow trout longnose dace longnose sucker predicted higher habitat quality wwps natural pools four species modelled flow rates however results fish sampling found significantly higher fish biomass four species natural pools compared wwp pools hydraulic metrics depth depth averaged velocity turbulent kinetic energy vorticity higher magnitudes wwp pools natural pools wwp pools model results described spatial distribution flow characteristics magnitude variables better results supports use modelling complex flows found wwps improved understanding linkages fish habitat quality hydraulic descriptors needed copyright john wiley sons ltd
context patient family dissatisfaction may result satisfied physician patient interaction although physician may feel worked hard provide information patient family new approaches visual analysis identify significant insights physicians personal clinical experiences providing compassionate palliative care end life care provide effective practical vehicle communicating patients families professional caregivers objectives elucidate palliative physicians core experiences patients dying death methods qualitative visual analysis conducted images created physicians completing one year palliative medicine fellowship images part larger personal reflections narratives database images text auditory projects prepared students interns fellows completing training palliative care large hospice provider participation personal reflections project required part training program goal blending clinical competencies lived experiences caring dying results two categories visual metaphors underlying images identified expressing relationship transitional dynamics life death portraits nature conventional images representing anxiety pain dimensions suffering commonly associated death dying virtually absent conclusion propose communication positive hopeful even peaceful perceptions death dying likely result effective personal professional skills gained physicians clinical experiences fellowship american academy hospice palliative medicine published elsevier inc rights reserved
undergraduate medical curricula typically include forensic legal medicine topics highly sensitive nature examples include suicide child abuse domestic sexual violence likely students direct indirect experience issues prevalent society students vulnerable vicarious harm partaking medical education even students direct indirect experience issues may vulnerable vicarious trauma particularly students especially empathetic cases presented despite risks instruction relating topics necessary ensure competencies graduating doctors respond appropriately cases encounter professional careers however risk minimised well designed thoughtfully delivered educational programme provide recommendations successful inclusion sensitive forensic legal medicine topics undergraduate medical curricula elsevier ltd faculty forensic legal medicine rights reserved
sustainable architectural design process complicated traditional building design regulations require calculations comparisons also need considered article sustainability parameters accepted standards green building certification systems leed breeam local climate conditions local building regulations conflicting criteria according sustainability parameters result pareto genetic algorithm chosen address multiple objectives incorporating pareto concept domination efficient sustainable design developed conceptual stage important decisions made decision support system developed help pareto based non dominated genetic algorithm nsga evaluate several possibly conflicting objectives article discusses model aims produce site layout alternatives according sustainability criteria social housing units
paper introduces architecture emotion aware ambient intelligent gerontechnological project named improvement elderly quality life care smart emotion regulation objective proposal find solutions improving quality life care elderly want continue living home using emotion regulation techniques series sensors used monitoring elderlies facial gestural expression activity behaviour well relevant physiological data way older people emotions inferred recognized music colour light stimulating means regulate emotions towards positive pleasant mood paper proposes gerontechnological software architecture enables real time continuous monitoring elderly provides best tailored reactions ambience order regulate older person emotions towards positive mood describing benefits approach emotion recognition regulation elderly eight levels compose architecture described
blomia tropicalis blo mite species considered storage mite temperate climate zones important source indoor allergens causing allergic asthma rhinitis tropical subtropical regions report crystal structure one allergens blo recombinant problo rproblo determined angstrom resolution overall fold rproblo characteristic pro form cysteine proteases class structural comparison experimentally mapped der der igg epitopes surface patch blo well sequence identity surface exposed residues suggests limited cross reactivity allergens blo agreement elisa inhibition results showing although cross reactive human ige epitopes exist unique ige epitopes blo der
joint polar satellite system jpss data product improvement requires substantial record orbit data extending years data record exists jpss instruments developed suomi national polar orbiting partnership snpp risk reduction mission snpp provided well three years orbit data four jpss instruments derived data products feasible apply system engineering approach data product improvement approach orbit performance characteristics traced back instrument algorithm design characteristics pre launch test data instrument development phase system engineering applied reverse direction trade optimize designs meet requirements based predicted performance key data product improvement comparison orbit performance performance predicted prelaunch feedback comparison findings design development process future jpss instruments algorithms
purpose study develop investigate employer based month intervention high school youth autism spectrum disorder learn job skills acquire employment intervention modified program titled project search incorporated use applied behavior analysis develop project search plus autism spectrum disorder supports randomized clinical trial compared implementation project search plus autism spectrum disorder supports high school special education services usual participants high school aged individuals ages years diagnosed autism spectrum disorder eligible supported employment students also demonstrate independent self care months post graduation treatment group acquired competitive part time employment earning per hour furthermore individuals maintained employment months post graduation control group employment outcomes acquiring employment months post graduation acquiring employment months post graduation positive employment outcomes generated treatment group provide evidence youth autism spectrum disorder gain maintain competitive employment additionally evidence able advance within time toward weekly hours worked also displayed increasing independence work setting
high utility sequential pattern husp mining emerged novel topic data mining although preliminary works conducted topic incur problem producing large search space high utility sequential patterns addition mainly focus mining husps static databases take streaming data account unbounded data come continuously often high speed efficiently deal problems propose novel framework mining high utility sequential patterns static streaming databases regard two efficient data structures named itemutillists item utility lists husp tree high utility sequential pattern tree proposed maintain essential information mining husps offline online fashions addition novel utility model called sequence suffix utility proposed effectively pruning search space husp mining propose algorithm named husp miner high utility sequential pattern miner find husps static databases efficiently one pass algorithm named husp stream high utility sequential pattern mining data streams proposed incrementally update itemutillists husp tree online find husps data streams best knowledge husp stream first method find husps data streams experimental results real synthetic datasets show husp miner outperforms compared algorithms substantially terms execution time memory usage number generated candidates experiments also demonstrate impressive performance husp stream update data structures discover husps data streams
study designed compare kicking motion female male soccer players determine mechanical technical characteristics kick female players motion capture system used compare ball velocity foot velocity mean peak knee joint torques angle thigh shank mean thigh shank energy ratio female male soccer players elucidate mechanical technical characteristics kick female players ball impact values ball velocity foot velocity immediately impact mean peak knee joint torques mean thigh shank energy ratio smaller female players male players authors published elsevier ltd selection peer review responsibility school aerospace mechanical manufacturing engineering rmit university
introduction social developmental processes child maltreatment increases risk marijuana use understudied study examined hypothesized parent peer pathways linking preschool abuse sexual abuse adolescent adult marijuana use methods analyses used data lehigh longitudinal study measures included child abuse physical abuse emotional abuse domestic violence neglect preschool sexual abuse age adolescent average age years parental attachment peer marijuana approval use well adolescent adult average age years marijuana use results confirming elevated risk due child maltreatment path analysis showed sexual abuse positively related adolescent marijuana use whereas preschool abuse positively related adult marijuana use support mediation found forms maltreatment negatively related parental attachment negatively related turn peers use approve marijuana use peer marijuana approval use strong positive predictor adolescent marijuana use strong positive predictor turn adult marijuana use conclusions results support social developmental theories hypothesize sequence events leading child maltreatment experiences lower levels parental attachment turn higher levels involvement pro marijuana peers ultimately adolescent adult marijuana use sequence events suggests developmentally timed intervention activities designed prevent maltreatment well initiation progression marijuana use among vulnerable individuals elsevier ltd rights reserved
association social networks improved mental physical health well documented literature mental health services rarely routinely intervene improve individual social network review summarises social participation intervention models illustrate different approaches practitioners use highlight gaps evidence base suggest future directions research systematic search electronic databases conducted social participation interventions grouped six categories using modified narrative synthesis approach nineteen interventions countries identified six evaluated using randomised controlled trial grouped together individual social skills training group skills training supported community engagement group based community activities employment interventions peer support interventions social network gains appear strongest supported community engagement interventions overall evidence limited small number heterogeneous studies included review quality appraised tentatively suggests social participation interventions may increase individuals social networks future research needs use experimental designs sufficient samples follow periods longer months enable make firm recommendations mental health policy practice
report discussed laboratory test results spad detectors ingaas inp avalanche photodiodes operating geiger mode device operating synchronous mode dead timer setting proper working conditions photodiodes report materials showing functional block diagram detector real operating signals receiver path clock circuits main results measurements input signal synchronous detector clock determines time positions expected photons arrival increasing clock speed mhz getting time positions time grid provide increased capacity time position code signals qkd information transmitted nets time maximum attainable speed photon reception limited diode dead time diode quantum noise minimized inclusion special time interval dead time usec received registered photon lowest attainable value dead time determined compromise transients electrical circuits passive avalanche quenching circuit thermal transients cooling crystal diode avalanche pass though photodiode achievable time speed parameters discussed specific examples detectors
programs essence collection implemented features feature discovery software engineering task identifying key functionalities program implements manual feature discovery time consuming expensive leading automatic feature discovery tools developed however approaches typically describe features using lists keywords difficult readers already familiar source code alternative keyword lists sentence selection one sentence chosen among sentences text document describe document sentence selection widely studied context natural language summarization beginning explored solution feature discovery paper compare four sentence selection strategies purpose feature discovery two shelf approaches two adaptations propose present findings guidelines recommendations designers feature discovery tools copyright john wiley sons ltd
severe forms acute respiratory distress syndrome patients haematological diseases expose clinicians specific medical ethical considerations prospectively followed patients haematological malignancies whose lungs mechanically ventilated period sought identify prognostic factors long term outcome particular evaluate impact severity acute respiratory distress syndrome patients secondary objective identify early first icu admission predictive factors acute respiratory distress syndrome severity evolutive haematological disease moderate severe acute respiratory distress syndrome need renal replacement therapy associated long term mortality resolution neutropaenia icu stay early microbiological documentation associated survival extent pulmonary infiltration observed first chest ray diagnosis invasive fungal infection relevant early predictive factors severity acute respiratory distress syndrome
aim study examine informational cues male female students perceive influential developing initial impressions expectancies lecturer university students rated extent informational cues influence initial perceptions lecturer following exploratory factor analysis efa five factor model appearance app accessories acc third party reports tpr communication skills nationality ethnicity extracted male students five factor model acc tpr app interpersonal skills ips engagement eng extracted female students inspection mean scores identified male students rated clarity voice tpr qualifications female students ips control class eng eye contact tpr influential factors forming initial impressions expectancies lecturer findings identify potential expectancy effects within student lecturer interactions
probabilistic relational database probability distribution set deterministic relational databases namely possible worlds efficient updating information probabilistic databases required several applications sensor networking data cleaning way update probabilistic database conditioning refines probability distribution possible worlds based general knowledge functional dependencies existing methods conditioning exponential number variables probabilistic database arbitrary constraint paper constraint based conditioning framework proposed solves conditioning problem considering variables given constraint prove correctness proposed approach provide efficient algorithms step approach afterward pruning strategy significantly improve efficiency constraint based approach proposed functional dependency constraints furthermore functional dependency constraints variable elimination strategy minimizes number generated variables benefit subsequent query processing experimental study shows constraint based approach efficient approaches described literature effectiveness two optimization strategies functional dependency constraints also demonstrated experiment elsevier rights reserved
widespread dissemination smart mobile devices offers new perspectives timely data collection large scale scenarios however realizing sophisticated mobile data collection applications raises various technical issues like support different mobile operating systems platform specific features often specifically tailored mobile applications implemented order meet particular requirements context changes data collection procedure become costly profound programming skills needed adapt respective mobile application accordingly remedy drawback developed model driven approach enabling end users create mobile data collection applications basis approach elements flexibly defining sophisticated questionnaires called instruments contain information data collected also instrument shall processed different mobile operating systems latter purpose provide advanced mobile kernel service capable processing logic sophisticated instruments various platforms paper discusses fundamental requirements kernel introduces generic architecture feasibility architecture demonstrated prototypical implementation altogether mobile service allows effective use smart mobile devices multitude different data collection application scenarios clinical psychological trials
cytoplasmic fmrp interacting protein cyfip candidate gene intellectual disability autism schizophrenia epilepsy member family proteins highly conserved evolution sharing high homology drosophila homolog dcyfip cyfip interacts fragile mental retardation protein fmrp encoded fmr gene whose absence causes fragile syndrome translation initiation factor eife member thewave regulatory complex wrc thus representing link translational regulation actin cytoskeleton present data showing correlation mrna levels cyfip members wrc suggests tight regulation levels wrc members post translational mechanisms previously hypothesized moreover studied impact loss function cyfip fmrp neuronal growth differentiation two animal models fly mouse show two proteins antagonize function neuromuscular junction growth fly also new neuronal differentiation olfactory bulb adult mice mechanistically fmrp cyfip modulate mtor signaling antagonistic manner likely via independent pathways supporting results obtained mouse well fly morphological level collectively results illustrate new model explain cellular roles fmrp cyfip molecular significance interaction
background aim learning changes communication deaf dementia dwd important order improve services support dwd families explored family members views changes communication dwd ways communication adapted due progression dementia methods qualitative content analysis thematic interviews conducted eight close family members dwd results decreasing vocabulary increasing sign finding difficulties conversations became poorer dwd tended diverge topic nonverbal communication became important verbal communication abilities dwd deteriorated adult children took active role taking initiative guiding conversations conclusion dwd seem similar changes communication hearing people dementia adult children dwd need get used interpreting assisting parent communication different phases dementia
previous research suggests voting elections influenced appearance based personality inferences whether political candidate competent looking face however since voters objectively evaluate politicians personality traits remains seen whether appearance based inferences characteristic continue influence voting clear information characteristic available authors examine impact appearance based inferences characteristic well known candidates political affiliation across two studies authors show candidates facing conservative electorates benefit looking stereotypically republican rivals controlling gender ethnicity age contrast relationship political facial stereotypes voting found liberal electorates using identical controls authors show contrast liberal conservative electorates individual level differences liberal conservative voters macro level differences liberal conservative states
norplant brand name world first registered subdermal hormonal contraceptive implant developed laboratories population council international organisation working area fertility population growth article revisits trajectory contraceptive brazil arrival clinical trials eventual ban brazilian regulatory agency responsible approving medications time circulation generated controversies related research practices side effects political uses drug birth control method article focuses analysis divergences related research practices uses controversy analysis technique reviewing versions involved investigating understandings effects object generated networks norplant provoked displacements associations civil society groups state authorities scientists physicians industry pharmaceutical products research procedures bureaucratic instruments female users contraceptives scientific styles medical thought shaken new forms thinking scientific autonomy began discussed country
reference distributed architecture consisting sensor nodes connected wireless links arbitrary network topology consider segment oriented implementation single address space paradigm memory reference approach applications consist active entities called components distributed network nodes component accesses given segment presenting handle segment handle form pointer protected cryptographically handles allow effective implementation communications components key replacement number messages generated execution communication primitives independent network size key replacement mechanism well suited reliable application rekeying unreliable network
objective clarify whether altering temporomandibular joint tmj condyle disc positions occlusal splint splint therapy relieves tmj pain determine whether splint therapy facilitates improvement ranges condyle articular disc motions study design total joints patients admitted tmj pain discomfort evaluated visual analog scale tmj pain administered visits following start splint treatment start splint treatment mri performed without splint insertion condyle disc movements evaluated disc position function disc configuration joint effusion osteoarthritis bone marrow evaluated pearson correlation coefficients linear regression multiple regression analyses used statistical analysis results splint related anterior movement condyle related tmj pain biconvex disc bone marrow abnormality splint treatment ineffective reducing tmj pain conclusion splint therapy likely successful kind tmj abnormalities bone marrow abnormalities biconvex disc appearance mri european association cranio maxillo facial surgery published elsevier ltd rights reserved
oral facial digital syndrome type ofd omim linked dominant ciliopathy caused mutations ofd gene condition characterized facial anomalies abnormalities oral tissues digits brain kidneys almost affected patients female ofd presumed lethal males mostly first second trimester pregnancy live born males ofd rare occurrence five reported patients date four patients presence congenital heart defect chd observed report affected male fetus hemizygous novo mutation ofd gln ultrasound examination demonstrated severe hydrocephalus hypoplastic cerebellum hypoplastic left ventricle heart pregnancy terminated weeks gestation poor prognosis post mortem examination fetus confirmed severe hypoplasia left ventricle heart emphasize chds included phenotypic spectrum ofd males justifies molecular analysis ofd chd encountered prenatally combination one phenotypic features previously described ofd gene alteration spectrum underlying pathogenesis chd ofd ciliopathies probably involves dysfunction primary cilia regarding coordination left right signalling early heart development whether chds wholly partly result defective left right signalling different types cilia known play critical role remains topic research
subjects chronic kidney disease ckd suffer minimal trauma fracture problem differentiate osteoporosis various forms renal bone disease associated ckd mineral bone disorder problem exacerbated fact renal osteodystrophy may coexist osteoporosis world health organization bone mineral density bmd criteria osteopenia score osteoporosis score may used patients ckd stages ckd stages bmd dual energy ray absorptiometry dxa less predictive may underestimate fracture risk development absolute fracture risk afr algorithms frax garvan absolute fracture risk calculator predict risk fracture given time usually years aims incorporate non bmd risk factors clinical assessment frax shown useful assess fracture risk ckd may underestimate fracture risk advanced ckd trabecular bone score measure grey scale homogeneity obtained spine dxa correlates trabecular microarchitecture independent risk factor fracture recent data demonstrate potential utility trabecular bone score adjustment afr frax algorithm subjects ckd parameters bone microarchitecture using peripheral quantitative computed tomography pqct high resolution pqct also able discriminate fracture status subjects ckd however present convincing data addition pqct high resolution pqct parameters dxa bmd improves fracture discrimination advanced estimates bone strength derived measurements micro architecture qct derived finite element analysis may incorporated afr algorithms future
show display map category finite simplicial complexes seen representing totality database schemas instances single mathematical structure give sound interpretation certain dependent type theory model show allows syntactic specification schemas instances manipulation usual type theoretic operations indicate allows posing queries novelty type theory non trivial context constants
background ajuga remota benth traditionally used ethiopia management diabetes mellitus since claim investigated scientifically aim study evaluate antidiabetic effect phytochemical screening aqueous ethanol extracts alloxan induced diabetic mice methods acute toxicity test swiss albino mice induced alloxan get experimental diabetes animals fasting mean blood glucose level treatment two weeks normal diabetic untreated diabetic mice treated aqueous ethanol extracts performed data statistically evaluated using statistical package social sciences software version value considered statistically significant results medium lethal doses extracts higher indicating extracts toxic observable condition aqueous extracts remota body weight reduced elevated blood glucose levels respectively ethanol extract caused reduction treatment antidiabetic drug glibenclamide body weight lowered blood glucose level phytochemical screening extracts indicated presence phenolic compounds flavonoids saponins tannins steroids might contribute antidiabetic activity extracts however contain alkaloids anthraquinones conclusion aqueous extract showed highest percentage reduction blood glucose levels ability remota extracts reducing blood glucose levels presumably due presence antioxidant constituents flavonoids effect extract supported traditional claim plant
pharmacological intervention autism spectrum disorder asd important addition treatment yet currently available agents target morbid psychiatric concerns aggression irritability propranolol beta adrenergic antagonist anxiolytic effects shown improve verbal fluency working memory adults adolescents asd single dose challenges present pilot study explores acute effects propranolol measure conversational reciprocity population also examined whether autonomic activity anxiety moderate mediate response drug given relationships variables asd well drug effects within subject crossover design individuals asd received single dose propranolol placebo two sessions double blinded counterbalanced manner drug administration participants performed conversational reciprocity task engaging short conversation researcher measurements autonomic activity anxiety obtained drug administration propranolol significantly improved performance conversational reciprocity task total nonverbal communication domain scores compared placebo condition however neither autonomic activity anxiety significantly associated drug response acute propranolol administration improved conversational reciprocity asd exploration preliminary findings well potential treatment response predictors serial doses warranted
emphasis early identification atypical development increased evidence supporting efficacy intervention grown increases also directly affected availability funding providers early intervention services majority research focused interventions specific individual primary diagnoses example interventions cerebral palsy traditionally focused physiological symptoms intervention individuals autism spectrum disorder asd focus socialization communication restricted interests repetitive behaviors however deficits areas related primary diagnoses communication adaptive behaviors social skills prevalent atypically developing populations significant predictors quality life therefore purpose current study examine impairments socialization nonverbal communication individuals syndrome comorbid asd individuals comorbid asd exhibited significantly greater impairments diagnostic group alone however individuals also exhibited significantly greater impairments implications results discussed elsevier ltd rights reserved
discuss features thermodynamics presence multiple conserved quantities prove generalisation landauer principle illustrating tradeoffs erasure costs paid different currencies show maximum entropy complete passivity approaches give different answers presence multiple observables discuss seems prevent current resource theories fully capturing thermodynamic aspects non commutativity
textures widely used modern computer graphics size however often limiting factor considering widespread adaptation mobile virtual augmented reality applications efficient storage textures become important factor present approach analyse textures given mesh compute new set textures goal improving storage efficiency reducing memory requirements process texture coordinates mesh updated required textures analysed based coordinates one meshes deconstructed per triangle textures analysed detect single coloured well identical per triangle textures approach aims remove redundancies order reduce amount memory required store texture data analysis per triangle textures compiled new set texture images user defined size algorithm aims pack texture data tightly possible order reduce memory requirements
considered healthy neurons central nervous system cns express major histocompatibility complex mhc class molecules however recent studies clearly demonstrated expression functional mhc class mammalian embryonic neonatal adult brain still unknown whether mhc molecules expressed development human brain collected nine human brain tissues fetuses aged gestational weeks one newborn postnatal days one adult expression mhc class molecules detected development visual system human brain immunohistochemistry immunofluorescence mhc class proteins located lateral geniculate nucleus lgn expression gradually increased reached high levels fine scale refinement phase mediated neural electric activity however expression mhc class molecules visual cortical cortex developmental stages examined also concluded mhc class molecules mainly expressed neurons astrocytes lgn developing visual system expression beta protein neurons found study
prevalence depression anxiety schizophrenia drug alcohol use disorders peaks adolescence adult mental health disorders emerge adolescence adolescence prefrontal cortex pfc undergoes dramatic structural reorganization dendritic spines synapses refined pruned stabilized understanding molecular mechanisms underlie processes help identify factors influence development psychiatric illness briefly discuss anatomical connections medial orbital prefrontal cortex mpfc ofc respectively present original findings suggesting dendritic spines deep layer excitatory neurons mouse mpfc ofc prune different adolescent ages later pruning ofc parallel used western blotting define levels several cytoskeletal regulatory proteins early mid late adolescence focusing tropomyosin related kinase receptor trkb integrin containing receptors select signaling partners identified regional differences levels several proteins early midadolescence converged early adulthood also observed age related differences trkb levels full length truncated isoforms rho kinase synaptophysin pfc subregions finally identified changes protein levels dorsal ventral hippocampus distinct pfc conclude general review manner trkb integrin mediated signaling influences neuronal structure postnatal brain elucidating role cytoskeletal regulatory factors throughout adolescence may identify critical mechanisms pfc development wiley periodicals inc
purpose study aimed presenting discussing device related complication management year period sacral nerve modulation snm tertiary care university unit methods retrospective chart review women received snm department may may two stage procedures performed experienced surgeon according strict protocol patients selection follow data perioperative postoperative complications management collected results test stimulation positive patients received permanent implantation mean test phase duration days mean overall follow months recorded complications patients mean follow time days comprise lead migration infection pain wound healing disorders lead fibrosis event patient ratio significantly reduced beginning experience snm second period study complications could successfully resolved surgical intervention without influence treatment effect conclusion complications snm common may require additional surgical intervention full resolution without affecting treatment effect also due learning curve lower events patient ratio time expected
closed loop heat pump drying system particular characteristics paper simultaneous control strategy proposed improve precision superheat drying temperature stability drying temperature guarantees quality drying material premise superheat accurate stable improve energy usage two fuzzy controllers employing different membership functions control rules used achieve stable drying temperature superheat controller mainly composed pid controller conversion emergency controller accelerates response electronic expansion valve experimental results show temperatures outlet indoor outdoor condensers give smaller fluctuations variations superheat investigated temperature drying chamber changes ambient temperature degrees degrees degrees respectively experimental data confirm new controller applicable decrease nonlinearities superheat drying temperature elsevier ltd rights reserved
background doctors verbal non verbal communication skills impact patients health outcomes important medical students develop skills traditional non verbal communication skills training involve tutor manually annotating student non verbal behaviour patient doctor consultations time consuming tele conference systems used verbal communication skills training methods describe eqclinic system enables verbal non verbal communication skills training tele consultations simulated patients sps evaluation exercises promoting reflection students sps tele consultations tele consultation component component sps provide feedback students thumbs thumbs tool comments box eqclinic automatically analyses communication features recorded consultations facial expressions provides graphical representations pilot study investigated whether eqclinic helped students aware non verbal behaviour improve communication skills evaluated usability platform students received automated feedback tutor evaluations completed self assessment reflection questionnaires results eight medical students three sps conducted tele consultations using eqclinic students paid attention non verbal communication students engaged two consultations felt confident second consultation students rated system positively felt comfortable using reported structure information clear pilot provides evidence eqclinic helps positively influences medical students practise communication skills sps using tele conference platform discussion easy improve non verbal communication skills short time period evaluation eqclinic larger numbers ascertain learning gains application health professional training developing standard model assessment non verbal behaviour tele consultations providing students valuable evaluation suggestions part future work
research empathic development though extensive largely overlooked two vital facets flexible empathic respondingmultideterminism elicited response various cues context dependence empathic responding regulated depending contextual factors within dual process account empathic responding bottom top processes contribute flexible empathic responding relies heavily top processes yet developmental research systematically considered role top processes bringing multidetermined context dependent empathic responding provides narrow view early empathic responding recent research begun fill gaps suggests top processes involved even early flexible empathic responding much work needed particularly developmental mechanisms development top processes understand fully origins flexible concern
three types high performance permanent magnet machines designed analyzed order determine ideal candidate high speed traction application surface machine spoke machine interior machine compared terms performances capabilities high speed operation finite element analysis used accurate performances prediction sake accuracy amount type stator structure maintained design process three machines
cities across country experience influx white middle upper class residents new opportunities integration urban schools emerge yet crucial challenges persist even equity inclusion focus new stakeholders article explores story largely white group parents committed investing reforming gentrifying neighborhood elementary school given numerous tensions ensued fostering leadership equity intercultural awareness remains vital ensuring new urban diversity also produces inclusive schools
model verification validation one important activities simulation modelling model validation especially challenging agent based simulation abs techniques help improve simulation modelling needed paper proposes technique called test driven simulation modelling tdsm applies techniques test driven development software engineering simulation modelling main principle tdsm unit test simulation model specified simulation model implemented hence tdsm explicitly embeds simulation modelling use case study maritime search operations demonstrate tdsm used practice maritime search operations search operations general one classic applications operational research hence use analytical models vast search theory literature unit tests tdsm results show tdsm useful technique verification validation simulation models especially abs models paper also shows abs offer alternative modelling approach analysis maritime search operations elsevier rights reserved
little known quality socially anxious individuals romantic relationships present study examine associations social anxiety social support relationships study collected self report data social anxiety symptoms received provided perceived social support undergraduates romantic partners one year later couples contacted determine whether still relationship results indicated men social anxiety time predicted higher rates breakup time men women perceived support well men provided support also significantly predictive breakup social anxiety interact support variables predict breakup study subset undergraduate couples partner high low social anxiety completed two minute lab based video recorded social support tasks partners rated received provided social support following interaction trained observers also coded support behaviors results showed socially anxious individuals received less support partners interaction according participant observer report high lower social anxiety couples differ terms target provision support taken together results suggest social anxiety associated difficulties even context established romantic relationships clinical implications discussed
objective determine prevalence eating disorders eds women polycystic ovary syndrome pcos effects eds health related quality life design cross sectional study setting university practice patient women pcos rotterdam criteria controls seen routine gynecologic care intervention eating disorder examination questionnaire ede night eating questionnaire neq hospital anxiety depression scale health related quality life questionnaire pcosq main outcome measure ede neq scores prevalence bulimia nervosa binge eating disorder bed night eating syndrome nes result women pcos increased risk overall abnormal ede scores compared controls odds ratio confidence interval clinically significant elevated scores noted shape weight concern unadjusted analysis body mass index elevated depression score elevated anxiety score associated abnormal ede global score multivariable model pcos associated abnormal ede global score adjusted elevated ede scores inversely correlated pcosq scores prevalence bed nes women pcos differences compared controls conclusion women pcos especially concurrent anxiety symptoms independent obesity significantly increased risk abnormal ede scores findings suggest need routine screening population american society reproductive medicine
port scans typically begin chain events lead attack exploitation host network since building effective defense relies information kind threat organization facing threat intelligence outlining actor modus operandi critical ingredient network security paper describe characteristic patterns port scan packets used identify tool chain used adversary empirical analysis scan traffic received two networks find common open source port scan tools adopted differently communities across globe groups specializing use particular tool also specialized exploit particular services
thrifty genotype phenotype hypotheses developed explain rapid increase diabetes obesity developed countries around world subsequent thrifty research focused early developmental origins metabolic syndrome cardio metabolic disease goal manuscript review emerging line research uses similar thrifty framework understand early developmental origins eating related phenotypes primary relevance many psychiatric disorders given important role environmental adversity various psychiatric disorders involve overeating early age onset likely several thrifty mechanisms relevant regard understanding early origins increased eating behaviour based thrifty model might point way highly targeted preventative interventions critical periods development provide new way addressing common difficult treat disorders
physical appearance comparison scale pacs commonly used validated measure body related social comparison habits investigate reliability construct validity pacs german sample participants men women women confirmed diagnosis anorexia nervosa completed pacs along measures eating disorder pathology body image self esteem results show adequate internal consistency pacs female subgroups medium high correlations eating disorder pathology body image self esteem pacs total score differed significantly groups men scoring lowest women anorexia nervosa scoring highest conclude pacs sufficiently reliable valid measure body related social comparison habits women men used special care pacs generally suitable promote patient studies testing role social comparisons patho mechanisms eating disorders
paper concerned sampled data leader following consensus group agents nonlinear characteristic distributed consensus protocol probabilistic sampling two sampling periods proposed first general consensus criterion derived multiagent systems directed graph number results several special cases without transmittal delays deterministic sampling obtained second dimension reduced condition obtained multiagent systems undirected graph shown leader following consensus problem stochastic sampling transferred master slave synchronization problem one master system two slave systems problem solving independent number agents greatly facilitates application large scale networked agents third network design issue addressed demonstrating positive active roles network structure reaching consensus finally two examples given verify theoretical results
sole del rare finding myeloid neoplasms clinical significance largely unknown report patients isolated del acute myeloid leukemia aml myelodysplastic syndromes mds chronic myelomonocytic leukemia cmml primary myelofibrosis pmf aml remission seven patients large small del clone patients aml acquired del either disease relapse disease progression became refractory therapy died shortly thereafter median months detection del patients mds cmml pmf appeared predict poorer prognosis patients experienced disease progression transformation aml months remaining patients aml aml remission del detected metaphases transient finding appear clinical impact conclude detection del myeloid neoplasms presents major clone often poses high risk disease progression refractoriness therapy whereas del presents small clone may carry clinical significance elsevier ltd rights reserved
work channel high voltage stimulation chip rehabilitation stroke patients surface stimulation presented chip receives control data serial peripheral interface controlled external microcontroller accordingly generate biphasic stimulation currents different amplitudes duration time frequencies polarities channel independently chip designed fabricated using fab mixed signal process circuits carefully designed ensure operations hvs measurement results showed supply voltage high achieved current driver generate biphasic stimuli current amplitudes copyright john wiley sons ltd
purpose human breath analysis proposed increasing frequency useful tool clinical application performed study find characteristic volatile organic compounds vocs exhaled breath patients idiopathic pulmonary fibrosis ipf discrimination healthy subjects methods vocs exhaled breath ipf patients healthy controls measured using multi capillary column ion mobility spectrometer patients examined pulmonary function tests blood gas analysis serum biomarkers interstitial pneumonia results detected voc peaks exhaled breath ipf patients controls ipf patients showed significant voc peaks cymene acetoin isoprene ethylbenzene unknown compound voc peak cymene significantly lower voc peaks acetoin isoprene ethylbenzene unknown compound significantly higher compared peaks controls comparing voc peaks clinical parameters negative correlations fvc fvc dlco dlco positive correlation found cymene conclusion found characteristic vocs exhaled breath ipf patients among voc peaks cymene related clinical parameters ipf vocs may useful biomarkers ipf
meet heating demand north china reduce pollution traditional chinese kang novel combined heating system consists solar kang system solar air heating system proposed solar air system built residents daily heating demand solar kang system store solar energy collected daytime provide good sleeping environment night study demonstration buildings built huzhu qinghai province one chosen test thermal performance three different operation modes solar air system works solar kang system works whole combined system works tested mathematic model room combined system built based demonstrating building output simulation results compared experiment data result shows combined system rise indoor air temperature significantly simulation result fit experiment well indoor air temperature keep degrees ambient average temperature degrees kang surface temperature keep degrees night condition study proves excellent heating performance combined system elsevier rights reserved
gendered nature agricultural sector significantly influenced political socio economic cultural structure society division labor males females within family farm seriously affected response economic pressures along impact restrictions imposed predetermined gender roles palestinian context economic pressures created mainly structural transformation palestinian agriculture following zionist settler colonization palestine along minor factors related palestinian neoliberal economic policies dictated international financial institution zionist interests article argues gendered nature palestinian agriculture sector transformed promoted women exploitation follows first restructure agricultural employment decline women men employment total palestinian labor force within serious exploitive fluctuating conditions second changes tasks division labor women property rights agricultural land resources services provided palestinian authority finally increasing women burden increasing time allocation agricultural tasks data presented article based comprehensive analysis secondary information palestinian agriculture primary data collected help households case studies life history two locations central region west bank
paper introduces integrated magnetic gear intended direct drive next magnetic equivalent circuit presented gear topology proposed approach uses principle virtual work torque calculation takes magnetic leakage saturation account thereby approach focuses reduction computation time compared finite element simulation finally suggested approach verified results finite element simulation
thermodynamic analyses focused determination theoretical equilibrium concentrations hcl lao laoco cexoy based sulfur compounds sorbents possible interferences hydrogen halides removal temperature range upstream selective deep removal hcl producer gas minimization gibbs energy system used complicated situations lowest concentration ppm attained ceo based sorbents temperatures oxidation ceo based sorbents less efficient higher oxides limit ceo thermodynamically preferred real producer gas presence gas phase leads formation lanthanum oxy carbonate laoco lower efficiency removal lao thermodynamic analyses also focused suitable ways conditions regeneration spent desulfurization sorbents ceos laos corresponding oxides oxy carbonates temperatures ceos based spent cerium sorbents advantageously regenerated reaction temperatures way ceo elemental sulfur small concentrations theoretically produced cerium halides formed decomposition full sorbent regeneration thermodynamically possible rather reaction steam based spent sulfur sorbents restored reaction vapor leading formation laoco suitable operating conditions involve temperatures higher operating pressures potential small contents oxy halides laof laocl spent sorbent converted laoco regeneration process elsevier ltd rights reserved
article provides overview historical arguments surrounding reproductive health policy current policy initiatives reproductive policy vast subject matter sometimes blurry boundaries struggle concerning advent birth control used illustrate historic complexities policy affecting wide array individuals battle introduction birth control pill pertinent arguments used today debates reproductive health policy
advancement technologies power requirement around globe tremendously increasing putting extra loads grids existing grids bear load also provide interface distributed renewable energy sources dres building new lines substations alone serve purpose overcoming energy shortfall thus major transformation electricity infrastructure need hour meet ever growing demands electricity converting current power management system smart autonomic system pertinent achieve increasing amount renewable energy generation paper presents comprehensive review advances control smart grids various robust adaptive strategies spotlighted detailed description control overloads power smart grids also power generation storage management techniques development operational schedule sources loads elaborated recently reported systems information communication technologies ict techniques smart grid highlighted renewable energy potential eliminate current electricity crisis pakistan energy sector solar wind hydro biogas biomass alternative energy resources found abundantly country tremendous potential offer environment friendly energy solutions depth study reveals lot opportunities potential smart grid technology exist developing countries like pakistan need exploited cope energy crisis
paper presents results comparative analysis among three methods attributing responsibilities voltage unbalance electrical network namely iec three phase power flow conforming nonconforming currents methods computational experimental simulations carried based employing system comprised perfectly transposed transmission line two loads always balanced cases selected study also permit identification main advantages disadvantages method evaluation work characterized topic great interest regulatory agencies responsible establishing regulations utilities consumers relevant using methods investigated paper identification sources generates unbalance division responsibilities application penalties due limit transgression possible
recent years updating inventory road infrastructures based field work labor intensive time consuming costly fortunately vehicle based mobile laser scanning mls systems provide efficient solution rapidly capture three dimensional point clouds road environments high flexibility precision however robust recognition road facilities huge volumes point clouds still challenging issue complicated incomplete structures occlusions varied point densities existing methods utilize point object based features recognize object candidates extract limited types objects relatively low recognition rate especially incomplete small objects overcome drawbacks paper proposes semantic labeling framework combing multiple aggregation levels point segment object features contextual features recognize road facilities road surfaces road boundaries buildings guardrails street lamps traffic signs roadside trees power lines cars highway infrastructure inventory proposed method first identifies ground non ground points extracts road surfaces facilities ground points non ground points segmented individual candidate objects based proposed multi rule region growing method multiple aggregation levels features contextual features relative positions relative directions spatial patterns associated candidate object calculated fed svm classifier label corresponding candidate object recognition performance combining multiple aggregation levels contextual features compared single level point segment object based features using large scale highway scene point clouds comparative studies demonstrated proposed semantic labeling framework significantly improves road facilities recognition precision recall particularly incomplete small objects international society photogrammetry remote sensing inc isprs published elsevier rights reserved
aetiology eating disorders eds unclear many hypotheses implicate alterations behavioural control specifically relevance symptomatology much interest inhibitory control ability inhibit inappropriate unwanted behaviours studied relation reactive motor inhibition withholding response reaction signal reward based inhibition temporal discounting paradigms reversal learning set shifting tasks assessing cognitive flexibility compulsivity however less explicit exploration proactive inhibitory control preparatory form inhibitory control responses pre emptively suppressed improve performance either terms dynamic strategy post error slowing general suppression context uncertainty appropriateness response less certain review considers proactive inhibition within context broader conceptual considerations inhibitory control eds discusses existing behavioural neural evidence concludes construct worthy exploration elsevier ltd rights reserved
new exciting science however nonverbal communication takes significant place english classroom teaching thesis starts definitions non verbal communication focuses usages non verbal communication english classroom teaching basis current situation english teaching use body language space language environment language though using strategies techniques teachers students ability non verbal communication greatly improved
date best authors knowledge almost studies performed around hemodynamics bileaflet mechanical heart valves heart rate beats min considered fact heart rate similar beats min represent entire normal physiological conditions aortic prosthetic valves function heart rates beats min may lead hemodynamic complications plaque formation thromboembolism patients study hemodynamic performance bileaflet mechanical heart valves wide range normal physiological heart rates beats min studied opening phase model considered study jude medical bileaflet mechanical heart valve inner diameter aortic position hemodynamics native valve jude medical valve studied variety heart rates opening phase results carefully compared results indicate peak values velocity profile downstream valve increase heart rate increases well location maximum velocity changes heart rate jude medical valve model also maximum values shear stress wall shear stresses downstream valve proportional heart rate models interestingly maximum shear stress wall shear stress values models range heart rate isbeats min similar growth compared native valve findings study may importance hemodynamic performance bileaflet mechanical heart valves may also play important role design improvement conventional prosthetic heart valves design next generation prosthetic valves percutaneous valves
porokeratosis defined disorder keratinization characterized one atrophic patches surrounded clinically histologically distinctive hyperkeratotic ridgelike border called cornoid lamella lesions commonly located sun exposed sides trunk extremities exclusive facial involvement also reported despite exact risk cutaneous malignancy developing porokeratosis unknown confirmed series case reports including squamous cell carcinoma basal cell carcinoma even melanoma although definite cure exists number treatment modalities topical medications laser light devices reported variable success although promising reports disseminated superficial actinic porokeratosis treated vitamin analogs rare satisfactory enough effect obtained also calcipotriol monotherapy report case disseminated superficial actinic porokeratosis year old female patient successfully treated combination topical calcipotriol betamethasone gel significant improvement noticed weeks almost full resolution clinical symptoms without appearance fresh lesions achieved second month best knowledge first report successful treatment full resolution short interval simultaneous application vitamin analog calcipotriol corticosteroid betamethasone combined one commercial product gel treatment keratinocyte proliferation disorder psoriasis vulgaris promising new entity seems effective simultaneous synergetic effects substations namely normalization proliferation keratinocytes calcipotriol one hand reducing inflammation corticosteroid another sun protection stays always mandatory well regular clinical observation regarding risk malignant transformation
novelty search evolutionary approach promotes phenotypic diversity population novelty search successfully applied wide range domains number variants proposed introduce multiple assessment directed novelty search madns exploits notion diverse population optimised phenotypic novelty may contain solutions multiple conflicting objectives show utilising madns algorithm evolutionary trajectory may simultaneously directed towards conflicting objectives conclude applying madns madns divergent evolutionary trajectory may directed provide simultaneous solutions multiple conflicting problems domains large potential exploration
many organizations asian countries struggling sustain information technology agenda beyond basic enterprise systems like enterprise resource planning erp implementation sustain real benefits enterprise system organizations require different paradigm information leadership contextually relevant governance structure supporting mechanisms chief information officer cio alone make erp deliver business value rather requires participation top management team present case presents dilemma faced real life indian manufacturing organization successful implementation erp reaping initial benefits organization feels creating incremental value though case pertains manufacturing industry equally relevant organizations across kinds industries banking insurance retail etc case highlights situation common many organizations developed objective appreciating need building understanding collective form leadership befitting governance structure respect management two specific tools information leadership grid governance matrix synthesized based upon literature review specific tools purpose
problem inter regional interchange scheduling presence stochastic generation load considered interchange scheduling technique based two stage stochastic minimization expected operating cost proposed directly solving stochastic optimization intractable equivalent problem maximizes expected social welfare formulated proposed technique leverages operator capability forecasting locational marginal prices obtains optimal interchange schedule without iterations among operators several extensions proposed technique also discussed
absorption loss inevitable metal based metamaterials mms due intrinsic loss metal constitutes major hurdle practical realization applications sub wavelength lens thus reduce losses becomes one major challenges field however inevitable loss also harnessed take positive role applications mms stealth technology types cloaking devices presentation brief review advances mms based absorbers present several schemes fulfill desired electromagnetic absorption properties linear nonlinear linear absorption experimentally demonstrated absorption performance ordinary microwave absorbing material evidently improved using electric resonance resulting array subwavelength metallic circuit elements nonlinear absorption show theoretically active linear magnetic permeability induces nonlinear absorption similar two photon absorption tpa electric field lossy kerr type nonlinear polarization
paper reviews important aspects microalgae potential source biodiesel production microalgae photosynthetic microorganisms grow rapidly variety environments unicellular multicellular structure depending species advantage self reproduction using solar energy converting chemical energy via photosynthesis process concludes full cycle days obtaining higher lipid yields terrestrial crops review shows several techniques methodologies used biodiesel production process microalgae well challenges must overcome large scale process bio refineries copyright john wiley sons ltd
aiming machine learning applications fast online learning required develop variant least squares svr lssvr model learn incrementally data eventually provide sparse solution vector possible incorporating lssvr model sparsification mechanism used kernel rls krls model introduced engel performance resulting model henceforth referred online sparse lssvr lssvr model comprehensively evaluated computer experiments several benchmarking datasets including large scale one covering number challenging tasks nonlinear time series prediction system identification convergence efficiency error bounds lssvr model also addressed results indicate proposed approach consistently outperforms state art kernel adaptive filtering algorithms providing sparse solutions smaller prediction errors smaller norms solution vector elsevier rights reserved
conventional power systems turn towards smart grids sgs fast pace transition may create new significant challenges existing electrical network security along many important features sgs cyber security emerged critical issue due interconnection several loads generators renewable resources communication network cyber physical attacks cpas classified major threatening sgs security may lead severe consequences large blackout destruction infrastructures cyber switching attacks csas part cpas start attract attention due severity speed destabilizing sgs present paper thyristor controlled braking resistor tcbr solution mitigate type attack tcbr enable stabilize target generator relatively short time
high rates mental health problems consistently found among immigrants refugee generating countries refugees family members may experienced similar traumas refugees likely undergone stressful asylum period study aims determine whether mental health differs using national registry data refugees non refugees countries compared primary healthcare service use mental health problems purchase psychotropic medicine refugees higher odds using primary health care services non refugees refugee women likely purchase psychotropic medicine non refugee women refugee men likely purchase anti depressants findings suggest refugees poorer mental health non refugees may due combination greater pre migration trauma post migration stressors enduring difficult asylum period
aim programmed cell death protein inhibitors common treatment strategy metastatic melanoma tumour entities clinical trials usually exclude patients preexisting autoimmune diseases thus experience inhibitor patient population limited patients methods metastatic melanoma patients preexisting autoimmune disorders previous ipilimumab triggered immune related adverse events irae undergoing treatment seven german skin cancer centres evaluated retrospectively regard flare preexisting autoimmunity development new preexisting irae well response therapy results total patients either preexisting autoimmunity group including two patients additional ipilimumab triggered autoimmune colitis ipilimumab triggered irae group therapy initiation six patients group two patients group required immunosuppressive therapy group flare preexisting autoimmune disorders seen patients new irae group patients showed flare ipilimumab triggered irae new irae flares preexisting autoimmune disorders irae managed immunosuppressive symptomatic therapy require termination therapy tumour responses group group unrelated occurrence autoimmunity conclusion preexisting autoimmunity commonly showed flare therapy flare ipilimumab triggered irae rare response rates unrelated irae therapy considered patients autoimmune disorders depending severity activity autoimmunity elsevier ltd rights reserved
paper presents microkernel architecture constraint programming organized around small number core functionalities minimal interfaces architecture contrasts monolithic nature many implementations design variables domains constraints remain external microkernel isolates propagation logic event protocols modeling constructions objective search blends control primitives host language search combinators completely transparent fully compositional way delivering natural search procedure one use native constructions tools debuggers empirical results indicate software engineering benefits incompatible runtime efficiency
study sought chart ontogenesis goat rumen histomorphometric examination scanning electron microscopy immunohistochemical analysis total goat embryos fetuses used first stage prenatal life birth appearance rumen primitive gastric tube observed days prenatal life crl gestation days crl crl gestation ruminal wall comprised three layers internal epithelial layer middle layer pluripotential blastemic tissue external layer serosa ruminal pillars visible days crl gestation days crl gestation ruminal papillae starting appear scanning electron microscopy days crl gestation small ruminal papillae observed protruding surface finally neuroendocrine cells synaptophysin syp detected days crl crl gestation glial cell markers glial fibrillary acidic proteingfap vimentin vim found days crl gestation days crl gestation respectively neuropeptide npy vasoactive intestinal polypeptide vip detected immunohistochemically days crl gestation days crl gestation respectively conclusion histomorphogenesis rumen goats similar reported deer rather slower observed sheep cattle anat rec wiley periodicals inc
address longitudinal relation adolescents habitual usage media violence aggressive behavior empathy seventh eighth grade high school students germany completed measures violent nonviolent media usage aggression empathy twice twelve months cross lagged panel analyses showed significant pathways media violence usage higher physical aggression lower empathy reverse paths aggression empathy media violence usage nonsignificant links similar boys girls links found exposure nonviolent media aggression violent media relational aggression physical aggression moderated impact media violence usage stronger effects media violence usage among low aggression group elsevier inc rights reserved
present accurate method numerical integration polynomials arbitrary polyhedra using divergence theorem method transforms domain integral integrals evaluated facets polyhedra necessity performing symbolic computation transformation eliminated using one dimensional gauss quadrature rule facet integrals computed help quadratures available triangles quadrilaterals numerical examples proposed method used integrate weak form navier stokes equations embedded interface method eim presented results show method accurate generalized widely used volume decomposition based methods moreover since method involves neither volume decomposition symbolic computations much easier computer implementation also present method efficient available integration methods based divergence theorem efficiency method also compared volume decomposition based methods moment fitting methods knowledge first article compares accuracy computational efficiency methods relying volume decomposition based divergence theorem elsevier inc rights reserved
human enterovirus hev considered essential human pathogen causes hand foot mouth disease young children several hev outbreaks observed many asia pacific countries past two decades significant fatalities however competent vaccines antivirals hev infection date thus critical priority delve search anti hev agents prior need gain knowledge distinct targets hev available exploited antiviral therapy review aims provide better understanding hev virology feature potential antivirals progressive clinical development respect elucidated mechanistic actions
combining high resolution level set surface tracking lower resolution physics inexpensive method achieving highly detailed liquid animations unfortunately inherent resolution mismatch introduces several types disturbing visual artifacts identify primary sources artifacts present simple efficient practical solutions address first propose unconditionally stable filtering method selectively removes sub grid surface artifacts seen fluid physics preserving fine detail dynamic splashing regions provides comparable results recent error correction techniques lower cost without substepping better scaling behavior second show modified narrow band scheme ensure accurate free surface boundary conditions presence large resolution mismatches scheme preserves efficiency narrow band methodology eliminating objectionable stairstep artifacts observed prior work third demonstrate use linear interpolation velocity advection high resolution level set surface responsible visible grid aligned kinks therefore advocate higher order velocity interpolation show dramatically reduces artifact three contributions orthogonal results demonstrate taken together efficiently address dominant sources visual artifacts arising high resolution embedded liquid surfaces proposed approach offers improved visual quality straightforward implementation substantially greater scalability competing methods
objectives schizophrenia accompanied impaired cortical inhibition measured several markers including cortical silent period csp thought csp measures gamma aminobutyric acid receptors gaba mediated inhibitory activity mutual roles schizophrenia disease drugs used treatment psychosis gaba mediated neurotransmission clear methods recruited drug naive patients first episode schizophrenia used transcranial magnetic stimulation assess csp prior initiating risperidone monotherapy four weeks later time rated severity psychopathology using positive negative syndrome scale panss results obtained data patients showed significant increase csp cohen treatment panss total score significantly lower individual subscores however correlation found csp panss conclusion study patients first episode schizophrenia demonstrated association risperidone monotherapy increase gaba mediated inhibitory neurotransmission
water plays central role plant biology efficiency water transport throughout plant affects photosynthetic rate growth influence scales deterministically productivity terrestrial ecosystems moreover hydraulic traits mediate ways plants interact abiotic biotic environment landscape global scale plant hydraulic traits important describing function ecological communities ecosystems plant hydraulics increasingly recognized central hub within network plant biology connected palaeobiology agronomy climatology forestry community ecosystem ecology earth system science grand challenges anticipating mitigating impacts climate change improving security sustainability food supply rely fundamental knowledge water behaves cells tissues organs bodies diverse communities plants workshop emerging frontiers plant hydraulics supported national science foundation held washington promote open discussion new ideas controversies regarding measurements analyses especially potential expansion scaled scaled inter disciplinary research strengthening connections plant hydraulic research allied fields global modelling efforts plant hydraulics increasingly recognized central hub relating fields within plant biology ecology evolution palaeobiology agriculture essential grand challenges anticipating mitigating impacts climate change improving security sustainability food supply workshop entitled emerging frontiers plant hydraulics supported national science foundation held washington summarize discussions including controversies regarding measurements analyses emerging frontiers scaled scaled inter disciplinary research strengthening connections research plant hydraulics allied fields global modelling efforts
one important processes beverage manufacturing companies bottle washing process bottles returned customers first cleaned bottle washer reused pneumatic valve bottle washing machine controls discharge clean bottles sometimes sticks fails results significant loss production plant since processes follow depend bottle washing machine main causes failure temperatures pressure outside required ranges also minor contributions moisture abrasive particles parameters controlled designing fuzzy logic controller using matlab found pressure temperature maintained bars degrees respectively moisture levels dust levels artificial intelligent technique whereby system able plan sense reason act learn human intelligent way two solutions developed control operation valve cases disturbances non linearity namely model reference adaptive fuzzy controller mrafc mrac pid controllers simulations carried mrafc design showed excellent tracking results compared mrac pid controller published elsevier
paper introduces video processing method designed specifically give researchers access players behaviors within commercially available shelf game insights players experiences videogame violence achieved automatically processing significant elements audio visual communication feedback moving image sound long periods uninhibited game play method exploits wealth significant behaviorally influential information conveyed player progress game information relate virtual progress maps mission logs player reserves acquisitions vitality health stamina levels name analyzing transmitted player play feedback based game metrics produced utilize content player perceives processes gameplay thus tying method directly individual player experiences method developed project addressed persistent concerns impact game violence translation societal violence method provided project alternative approach understanding use function violence within game systems taking research new direction approach research designs employed experimental psychological last decades
propose leadership theory moral concerns core sattvika leadership defined set purposive leader actions comprising knowledge driven cooperation initiated basis positive reasonably accurate assumptions executed morally responsible sustainably fruitful means secure flourishing followers collective enhances psychological capital psychological empowerment work engagement followers developing morally better persons enhances trust leader fellow followers develops ethical climate organization
design methodology three stage cmos otas operating subthreshold region presented procedure focused development ultra low power amplifiers requiring low silicon area able drive high capacitive loads indeed following presented methodology designed cmos ota technology occupies powered supply exhibits gain able drive capacitive load thanks proposed methodology ota able provide khz unity gain bandwidth consuming even high load considered moreover slew rate enhancer circuit addition class output stage allows average slew rate higher load comparison prior art shows improvement factor figures merit higher
background cases premature ovarian insufficiency poi known etiology aim review summarize associations mechanisms impact environment pathology main body abstract eligible studies selected electronic literature search pubmed database january february associated references published studies search terms included ovary follicle oocyte endocrine disruptor environmental exposure occupational exposure environmental contaminant pesticide polyaromatic hydrocarbon polychlorinated biphenyl pcb phenol bisphenol flame retardant phthalate dioxin phytoestrogen tobacco smoke cigarette cosmetic xenobiotic literature search conducted accordance preferred reporting items systematic reviews meta analyses prisma guidelines included human animal studies corresponding terms published english excluded articles included results concern ovarian pathology focused ovarian cancer polycystic ovary syndrome endometriosis precocious puberty also excluded genetic auto immune iatrogenic causes analysis finally excluded animal data concern mammals studies based results vitro culture data grouped according studied pollutants order synthetize impact follicular development follicular atresia molecular pathways involved ninety seven studies appeared eligible included present study even though directly address poi phthalates bisphenol pesticides tobacco reported substances negative impact ovarian function increased follicular depletion leading earlier age menopause onset effects found exposure occured different times throughout lifetime prenatal adult period possibly due different mechanisms main mechanism seemed increase atresia pre antral follicles conclusion environmental pollutants probably cause poi health officials general public must aware environmental effect order implement individual global preventive actions
sustainable manufacturing engineering becoming growing body knowledge upholded interest sustainability life cycle products processes however found unified framework research lines sustainable manufacturing driven paper reviews analyses research works focused topic showing trends emerging last fifteen years particular deeper focused sustainability machining processes study achieved sustainability point view triple bottom line defined basis three general dimensions economic ecological equity hand takes account tasks associated development improvement manufacturing technologies developed life cycle phases design modelling simulation optimisation assessment finally consequence framework provided allow integration sustainability context research professional practices machining processes elsevier ltd rights reserved
background side effects prescribed nonprescribed psychostimulant use understudied objectives study examined side effects prescribed nonprescribed psychostimulant use college sample attention possible gender differences methods undergraduates male ages years years years completed online survey included questions subjective side effects prescribed nonprescribed psychostimulant use results results suggested prescribed users frequently reported side effects compared nonprescribed users prescribed users females frequently reported appetite somatic anxiety related side effects compared males nonprescribed users females reported somatic anxiety related side effects males frequently reported loss sex drive sweating side effects conclusions importance findings suggest prescribed users psychostimulants frequently report side effects prominent gender differences line gender roles
study investigated morphology ventricular germinal zone neocortex cerebral hemispheres projection field motor area human fetuses dynamics week fetal development morphological study allowed clarify following patterns prenatal ontogeny human cns weeks intensive formation main sulci first order differentiating brain lobes observed weeks formation sulci first order completed weeks additional sulci characteristic individual formed spurt gyrification cortex weeks practically coincides completion neuronal differentiation formation motor neocortex structure latter characterized clear stratification cytoarchitectonic layers modular organization neurons vertical orientation cell columns weeks subsequent weeks prenatal development birth significant changes topography structure neocortex observed structural rearrangement ventricular germinal zone weeks prenatal development consists gradual reduction completed weeks criteria physiological reduction area zonal location glioblasts progressive decrease thickness weeks prenatal development
hydrological models always related time spatial domains model results produced models large microsoft component structured storage employed save model results lack mechanism reduce data size order tackle situation compressed structured storage method introduced based combining component structured storage zlib compression library method standard component rules complied containment common mechanism object reuse com applied simplify usage
intelligent fault diagnosis methods using machine learning techniques like support vector machines artificial neural networks widely used distinguish bearings health condition however though methods generally work well still two potential drawbacks facing massive fault data feature extraction process needs prior domain knowledge therefore lacks universal extraction method various diagnosis issues much training time generally needed traditional intelligent diagnosis methods newly presented deep learning methods research inspired feature extraction capability auto encoders high training speed extreme learning machines elms auto encoder elm based diagnosis method proposed diagnosing faults bearings overcome aforementioned deficiencies paper performs comparative analysis proposed method state art methods experimental results rolling element bearings data set show effectiveness proposed method adaptive mining discriminative fault characteristic also high diagnosis speed
simple methods fabricate photoelectrical devices using regular paper substrate sensors able detect ultraviolet visible infrared radiation using different paper additives experiment made test detection ultraviolet visible light consists irradiating light different wavelengths device made paper semiconductor crystals electrical current devices increases importantly bandgap energy semiconductor crystal reached test sensitivity infrared use paper devices impregnated salts glycerol increment electrical conductivity due augmentation ionic current carriers observe ionic conductivity paper increases paper irradiated infrared light hot objects phenomenon might due molecular structure cellulose absorbs energy infrared part spectrum
background aims standard care older patients oropharyngeal dysphagia poor stimulation transient receptor potential vanilloid might become pharmacological strategy patients study aimed compare therapeutic effect film food containing capsaicin patients methods crossover randomized trial patients provided capsaicin identical placebo least days apart patients reported symptoms repeated swallowing volume substance concentrations saliva cervical esophageal wall motion evaluated ultrasonographic tissue doppler imaging obtained capsaicin placebo administration results significantly patients took capsaicin experienced improvement symptoms took placebo salivary levels significantly increased capsaicin administration compared placebo effective group duration cervical esophageal wall opening significantly shorter capsaicin administration effective group furthermore significant negative correlation found duration cervical esophageal wall opening salivary levels conclusion elevated salivary concentrations stimulated capsaicin greatly improve safety efficacy swallowing shorten swallow response older patients karger basel
mathematical model two competitive populations migrations two patches manufacturing engineering proposed assumed migration rates two populations constants density dependent led mainly pressure interspecific competition conditions persistence system obtained shows appropriate migration rates facilitate two competitive populations cooperate well populations persistent every patch results confirmed computer simulations also found positive equilibrium globally stable changes bitable equilibrium parameters vary
four new binuclear nickel metallates synthesized reaction nicl center dot bis diphenylphosphino propane msal rtsc msal methoxysalicylaldehyde tsc thiosemicarbazone complexes characterized various spectral analytical methods distorted square planar geometry complexes evidenced crystal structures binding interaction calf thymus dna dna albumin bovine serum albumin analyzed absorption emission spectral titration studies based observations complexes act strong binders dna bsa antioxidant properties compounds evaluated test free radical scavenging ability complexes exhibited better antioxidant activity ligands found greater conventional standard vitamin cell proliferation mtt assays performed compounds human breast cancer mcf human cervical cancer cell line hela exposed significant growth inhibition complexes showed remarkably high cytotoxicity human cervical cancer cells hela human breast cancer cells mcf standard cisplatin among four complexes complex effective mcf value hela compared complexes respectively furthermore compounds resulted ros reactive oxygen species mediated apoptosis indicated dcfda dichlorodihydro fluorescein diacetate sub dna content measured fluorescent activated cell sorting facs analysis elsevier rights reserved
understanding complex problems climate change difficult nonaeuroscientists serious implications decision making policy support scientists generate complex computational models climate systems describe understand systems predict future states systems non scientists generate mental models climate systems perhaps aims perhaps aims often predictions computational models mental models correspond important implications human decision making policy support behaviour change recent research suggested non scientists poor appreciation simple foundations system dynamics root lack correspondence computational mental models report study uses simple computational model run mental models assess whether system evolve according aspirations considering policy choices provide novel evidence dual process model believe system works today function ideology worldviews believe system look future related general expectations future mismatch different aspects cognition may prevent establishing coherent link mental model assumptions consequences present future thus potentially limiting decision making policy support behaviour changes
postpartum depression ppd described common complication experienced postpartum affecting new mothers factors like history mental illness experienced recent adverse life events associated increased risk developing ppd immigrant women western countries found marked higher prevalence ppd compared general population norway prevalence ppd general population found around among pakistani immigrants rate found somali people norway second largest immigrant group norway non western background study ppd associated factors among somali women found literature aim study assess ppd associated factors among somali women greater oslo region norway cross sectional survey conducted recruiting new mothers maternity wards oslo region data collected interview administrated questionnaires ppd assessed using edinburgh postnatal depression scale epds defining scoring possible ppd eligible women identified consented participate completed study respondents assessed possible ppd important associated factors found history mental illness experienced technical assistance delivery self rated health experienced economical problems last months low prevalence ppd found prevalence associated factors interpreted caution associated factors enough power give strength associations however results used develop new hypotheses regard ppd among somali women immigrants western society
automatic data processing extraction rules large datasets gained considerable interest last years several approaches proposed mainly based statistical fuzzy sets approaches paper propose new view approaches represent large datasets find rules one makes use called information granulation computing words methods basic ideas principles granular computing studied explicitly implicitly many fields isolation recently renewed fast growing interest time extract commonality diversity fields study systematically formally domain independent principles granular computing unified model framework granular computing improved applying inherited principles space granulation computing shapes paper examine framework new perspectives granular computing based space granulation computing shapes granulated data processing problem solving authors published elsevier
numerical model piston dynamics lubrication analysis proposed coupling lubrication model piston skirt liner system dynamics model multibody system consisting crank connecting rod piston lubrication model solved finite element method multibody dynamics equations established lagrange multipliers constraint jacobian matrix validation method verified comparing well known existing work apart design parameters piston skirt investigated reveal influence slap noise lubrication performances piston elsevier ltd rights reserved
child maltreatment worsens prognosis quality life several psychiatric conditions meaning life construct relates sense purpose one perceive life key aspect recovery psychiatric patients lasting impact meaning life mediating variables studied patients chronic persistent psychiatric conditions one hundred sixty six patients bipolar disorder psychotic disorder anorexia nervosa borderline personality disorder assessed meaning life revised version life regard index lri childhood trauma questionnaire ctq internalized externalized psychopathology associated lower lri score structural equation modeling showed internalized psychopathology depression hopelessness low self esteem main mediator impact meaning life direct effect meaning life significant suffered negligence abuse childhood associated lower meaning life adults persistent pervasive psychiatric disorders treating depressive symptoms improving self esteem may improve meaning life patients severe mental disorders affected
aims aim study determine sustained therapeutic efficacy treatment intervals ptns noab offering periodic additional treatments year patients completed initial course consecutive weekly sessions methods total patients enrolled ptns treatment patients completed year ptns treatment tapering protocol months therapy respectively weeks therapy ptns applied day intervals months day intervals months day intervals months patients completed day voiding diary month patients requested complete validated questionnaires iciq oab oab carried within month intervals thereafter enrolment study results total patients enrolled study men women improvements voiding diary parameters significant months compared baseline mean values baseline month parameters suggested daytime frequency decreased voids daily urge incontinence decreased episodes daily urgency episodes decreased episodes daily nocturia decreased voids voided volume improved mean conclusion results demonstrated noab symptom improvement patients achieved weekly ptns treatments show excellent durability months wiley periodicals inc
modeling language hybrid systems hydla implementation hylagi described hydla constraint based language handle uncertainties models smoothly hylagi calculates trajectories symbolic formula manipulation exclude errors resulting floating point arithmetic hylagi features nondeterministic simulation algorithm calculate possible qualitative different trajectories models uncertainties
objectives examine trends relationship smoking history general central fatness adults mediterranean setting materials methods encat surveys used samples consisted men women men women aged years measured anthropometry self reported data smoking habits diet lifestyle ses collected general fatness defined bmi overweight obesity central fatness defined increased risk metabolic complications waist circumference substantially increased risk sir simple logistic regression used estimate multivariate adjusted associations general central fatness smoking history results associations observed strongly attenuated male current heavy smoking remained associated sir three fold female current moderate smokers times less likely sir conclusions although causality established results suggest positive association heavy smoking central fatness among men association former smoking general central fatness findings strengthen arguments promoting smoking cessation reduce smoking obesity associated morbidity mortality
light activated shape memory polymer lasmp novel smart material realizes shape memory function exposure laser lights two different wavelengths exposure process stiffness lasmps also changes noncontact actuation feature study presents new technique manipulate frequencies beams cylindrical shells fundamental lasmp mechanism stiffness manipulation presented first lasmp elastic coupled dynamic equations cylindrical shells coupled lasmps established first simplified governing equation beams case studies natural frequency cantilever beam laminated lasmp patches studied furthermore length lasmp patches varied broaden frequency variation range results show maximum frequency change ratio reaches beams simply supported cylindrical shell laminated lasmps inner outer surfaces also analyzed frequency varies lowest mode thus adopting lasmps manipulate structural frequencies new noncontact actuation technique vibration controls
experimental study conducted investigate influence frp confinement buckling behavior longitudinal steel reinforcing bars rebars columns subjected monotonic cyclic axial compression test results frp confined columns frp confined plain concrete columns control specimens presented particular attention evolution strains longitudinal steel rebars frp jacket load increases frp confined column subjected monotonic axial compression contribution longitudinal steel rebars overall axial load carried column deduced subtracting contribution frp confined plain concrete total axial load test results showed compressive stress strain response longitudinal steel rebars frp confined columns follows tensile testing axial stress reduces gradually due onset buckling deformation significant interactions found exist frp confinement buckling longitudinal steel rebars interaction carefully considered formulating constitutive laws longitudinal steel rebars frp confined concrete use theoretical modeling elsevier ltd rights reserved
increasing popularity dvfs dynamic voltage frequency scaling schemes portable low power applications demands highly efficient chip converters primary aim work enable increased efficiency chip conversion near threshold operation multi core architectures main idea supply nominal high chip voltage multi core processor cores voltage stacked generate near threshold low voltage based kirchhoff voltage law charge recycling however implicit conversion affected current imbalance cores push pull switched capacitor regulator designed keep mid voltage close near threshold value half stacked voltage domain self regulation capability combined push pull based switch capacitor regulator shown average efficiency conversion workload imbalance varying load
objective determine correlation serum total testosterone body mass index bmi waist hip ratio whr healthy adult males methods cross sectional study conducted nonsmoker healthy males aged years university employees selected convenience sampling technique detailed medical history clinical examination including bmi waist hip ratio whr calculation blood sampling carried measure serum total testosterone using facilities chemiluminescence assay clia technique dow chemical laboratory independent sample test used mean comparisons bmi whr low normal testosterone groups subjects nmol total testosterone blood placed normal testosterone group correlation testosterone bmi whr analyzed pearson correlation results mean age subjects included study years mean total testosterone nmol mean bmi whr respectively statistically significant differences observed mean values bmi whr two groups testosterone significant inverse correlation serum total testosterone bmi recorded study however testosterone significantly correlated waist hip ratio conclusion middle age men working duhs low level serum total testosterone obese individuals normal total testosterone level
purpose evaluate corneal parameters patients ankylosing spondylitis scheimpflug imaging also clarify associations disease severity clinical status corneal parameters methods fifty seven patients healthy subjects included cross sectional study participants underwent detailed ophthalmological evaluation corneal parameters measured pentacam addition schirmer test tear break time tbut corneal fluorescein staining ocular surface disease index osdi scores evaluated duration disease scores bath ankylosing spondylitis disease activity index basdai ankylosing spondylitis quality life scale asqol patients recorded laboratory evaluation consisted human leukocyte antigen hla erythrocyte sedimentation rate esr reactive protein crp results corneal parameters significantly different patients healthy controls mean central corneal thickness versus mean corneal volume versus reduced significantly patients compared healthy controls values tbut schirmer test scores significantly lower patients controls also corneal fluorescein staining osdi scores higher patients controls factors related corneal parameters dry eye tests tbut schirmer test corneal fluorescein staining osdi score crp conclusion patients thinner corneas compared control subjects may affected tear disfunction inflammatory processes
geographic differences manifestation psoriatic arthritis psa could related differences genetic environmental factors aimed compare disease activity functional status using validated outcome measures among patients psa different ethnicities living environment performed cross sectional study consecutive patients psa classified classification criteria psoriatic arthritis caspar criteria single center sociodemographic data clinical variables patient reported outcomes collected using standardized protocol disease activities assessed validated composite scores clinical disease activity index psoriatic arthritis cdapsa composite psoriatic disease activity index cpdai minimal disease activity mda physical function assessed health assessment questionnaire haq medical outcome study short form physical function subscales linear regression analyses performed identify variables associated disease activities physical function ninety eight patients men mean age duration psa years recruited indian overrepresented compared national distribution ethnicities compared chinese indian patients likely using biological therapies higher tender joint count worse enthesitis higher proportion indians higher disease activity categories measured cdapsa cpdai mda poorer physical function multivariable analysis ethnicity significantly associated haq compared chinese indians psa living environment worse disease activity physical function measured validated outcomes
ophiocoma erinaceus muller troschel ophiocomidae part extensive group echinoderm contains bioactive metabolites anti cancer potential brittle star saponin reported cervical cancer present study conducted evaluate anticancer effect extracted crude saponin saponin extraction conducted using conventional method froth test tlc ftir erythrolysis assay hela cervical carcinoma hncf normal cells treated different concentrations saponin fraction cytotoxicity examined mtt dapi annexin fitc flow cytometry addition apoptotic induced pathway studied using caspase assay evaluation ros generation bcl mrna level crude saponin showed cytotoxic properties hela cells icof without significant impact normal cells addition crude saponin increased sub peak flow cytometry histogram treated cells ros generation caspase activity dose dependent regulation bcl treated cells demonstrated saponin fraction trigger intrinsic apoptotic pathway cancer cells study provides valuable information apoptotic inducing effect saponin fraction offer new insights anticancer potential saponin promising candidate human cervical carcinoma
purpose evaluate novel approach adolescent pregnancy prevention scheduled educational clinic visits focusing retain patients within clinic system methods retrospective chart review conducted center adolescent pregnancy prevention privately funded clinic located urban setting serving adolescents young adults subjects included adolescent patients aged years seen january december primary outcomes studied month continuation rates birth control options total length follow time gaps follow incident pregnancies results stratified based age initial visit early adolescents aged years late adolescents aged years results patients met inclusion one visit seven incident pregnancies study period late adolescent group relative risk pregnancy among gap follow months compared without gap confidence interval early adolescents greater rate continuation birth control months compared late adolescents relative risk higher rates continuation months conclusions educational approach center adolescent pregnancy prevention may decrease adolescent pregnancy among high risk adolescents stay within clinic system educational model may effective early adolescents late adolescent patients published elsevier inc behalf society adolescent health medicine
work presents development two free graphical user interfaces guis called fastlognoter morisonform focused analysis behaviour offshore structures especially offshore wind turbines first one related aeroelastic analysis wind turbines second concerned seakeeping marine structures development tools carried using powerful software called lognoter tool free software knowledge management technology integrates computer programming allowing development guis guis give open platform conducting parametric study structural dynamic behaviour marine structures coupling permits user set suitable way evaluate new concepts marine structures finally application intensive analysis offshore wind turbines shown
local randomized task scheduling algorithm proposed fully connected multiprocessors combines two given task scheduling algorithms using local neighborhood search give hybrid two given algorithms objective show type hybridization give much better performance results terms parallel execution times two task scheduling algorithms selected dsc dominant sequence clustering algorithms cluster pair priority scheduling algorithm hybrid created local dsc cpps simply local task scheduling algorithm local task scheduling algorithm time complexity broken vertical bar broken vertical bar broken vertical bar broken vertical bar vertical bar broken vertical bar broken vertical bar broken vertical bar set vertices set edges task graph local task scheduling algorithm compared six algorithms dccl dynamic computation communication load dsc edge zeroing linear clustering rdcc randomized dynamic computation comm unicalion performance evaluation task scheduling algorithm shows gives improvement nsl normalized schedule length algorithms
explored computer vision techniques used detect engagement students completed structured writing activity draft feedback review similar activities encountered educational settings students provided engagement annotations concurrently writing activity retrospectively videos faces activity used computer vision techniques extract three sets features videos heart rate animation units microsoft kinect face tracker local binary patterns three orthogonal planes lbp top features used supervised learning detection concurrent retrospective self reported engagement area roc curve auc used evaluate classifier accuracy using leave several students cross validation achieved auc concurrent annotations auc retrospective annotations kinect face tracker features produced best results among individual channels overall best results found using fusion channels
along rapid advancement digital image processing technology image denoising remains fundamental task aims recover original image noisy observation explosive growth images internet one recent trend seek high quality similar patches cloud image databases harness rich redundancy therein promising denoising performance despite well understood benefits cloud based denoising paradigm would undesirably raise security privacy issues especially privacy sensitive image data sets paper initiate first endeavor toward privacy preserving image denoising external cloud databases design enables cloud hosting encrypted databases provide secure query based image denoising services considering image denoising intrinsically demands high quality similar image patches design builds upon recent advancements secure similarity search yao garbled circuits image denoising operations used different phase design best performance formally analyze security strengths extensive experiments real world data sets demonstrate design achieves denoising quality close optimal performance plaintext
interest skin increased number studies skin care also increased reduction skin density one symptoms skin aging reduces elasticity skin becomes reason wrinkle formation low level laser therapy lllt suggested one effective therapeutic methods skin aging hasten change skin density study presents effect minimally invasive laser needle system milns wavelength power skin density rabbits divided three groups group receive laser stimulation control group group test groups exposed milns energy rabbits dorsal side week respectively skin density rabbits measured every hours using ultrasound skin scanner
fluoxetine flx well known antidepressant drug class selective serotonin reuptake inhibitor exerts action inhibiting reuptake serotonin selectively studies demonstrated flx relaxes intestinal smooth muscle study aimed studying signal transduction pathway underlying muscle relaxation effect flx electrically stimulated rat ileal muscle contraction investigate possible mechanism involved various antagonists used found inhibition nitroarginine methyl ester ondansetron bicuculline enhanced relaxation effect flx however effect flx nullified presence atropine calcium channel modulator calcium ionophore potassium channel blockers tetraethylammonium chloride aminopyridine glybenclamide specific pathway inhibiting antagonists rho kinase inhibitor phospholipase inhibitor reversed antagonistic effect flx myosin light chain kinase inhibitor chelerythrine protein kinase inhibitor augmented flx induced inhibition effect taken together concluded flx exerts inhibitory effect electric field stimulation response rat ileal smooth muscle inhibition muscarinic receptors decrease intracellular calcium level inhibiting phospholipase opens potassium channels karger basel
several studies suggest relation repeated exposure extremely thin bodies media perceptual emotional disturbances body representation anorexia nervosa study utilized exposure paradigm investigate perceptual experience modulates body appreciation adolescents compared healthy adolescents twenty patients healthy controls exposed pictures thin round models required express liking judgments bodies variable weight brief exposure round models increased liking judgments round bodies thin bodies healthy adolescents furthermore exposure round models increased liking judgments thin round bodies adolescents patients show change liking judgments exposure thin models results point weak norm based reshaping body appreciation patients elsevier ltd rights reserved
background stratified personalised medicine targets treatments groups individuals disorder based individual heterogeneity shared factors influence likelihood response psychiatry traditionally defined diagnoses constellations occurring signs symptoms assigned categorical label schizophrenia trial methodology psychiatry evaluated interventions targeted categorical entities diagnoses equated disorders recent insights nosology neurobiology psychiatric disorder reveal traditional categorical diagnoses equated disorders argue current quantitative methodology inherits categorical assumptions allows discovery average treatment response relies composite outcome measures sacrifices valuable predictive information stratified personalised treatment psychiatry methods findings achieve truly stratified psychiatry propose operationalise two necessary steps first formal multi dimensional representation disorder definition clinical state second similar redefinition outcomes multidimensional constructs expose within patient differences response use categorical diagnosis schizophrenia conceptualised label heterogeneous disorders means introducing operational definitions stratified psychiatry using principles multivariate analysis demonstrate framework application clinical antipsychotic trials intervention effectiveness dataset showing heterogeneity patient clinical states trajectories treatment lost traditional categorical approach composite outcomes systematically review decade registered clinical trials cognitive deficits schizophrenia highlighting existing assumptions categorical diagnoses aggregate outcomes identifying small number trials could reanalysed using proposal conclusion describe quantitative methods development multi dimensional model clinical state disorders trajectories practically realises stratified psychiatry highlight potential recovering existing trial data implications stratified psychiatry trial design clinical treatment finally describe different kinds probabilistic reasoning tools necessary implement stratification
neurological soft signs nss studied axis disorders like schizophrenia obsessive compulsive disorder bipolar disorder alcohol substance abuse disorder aim study detection neurological soft signs antisocial personality disorder relation signs psychopathy study included antisocial men healthy control subjects sociodemographic form neurological evaluation scale hare psychopathy checklist applied antisocial subjects whereas sociodemographic form neurological evaluation scale applied controls antisocial men exhibited significiantly nss total score subgroups scales shown significant association psychopathy scores nss sequencing complex motor tasks nss tests subgroup scores similar relation also observed comparison psychopathy subgroups nss accepted endophenotypes schizophrenia also detected antisocial group significantly controls study significant relationship psychopathy nss may also hint role genetic mechanisms personality development though new extended studies larger sample size needed clarification relationship elsevier ireland ltd rights reserved
measure prosocial behavior depends social distance social discounting defined decrease generosity decision maker recipient social distance increases risk ubiquitous part modern life limited research relationship risk prosocial behavior present experiment empirically test whether risk influence social discounting use choice titration procedure examine effect data show independent risk participants less eager forego money exhibit selfishness toward specific person social distance increases findings reflected hyperbolic model interestingly risk influences shape social discounting function reflected notable different discount rates individuals make decisions risk yield smaller discount rate make decisions without risk risk subjects reduce less generosity function social distance furthermore distinct type generosity occurs typically among individuals distance recipients closest furthest social distance recipients
intimate partner violence sexual assault college students garnered increased attention publicity current studies focused primarily general campus populations little attention students disabilities studies suggest rate abuse individuals disabilities similar higher compared general population remains lack focus issue individuals disabilities particularly high risk abuse typical forms violence physical sexual emotional economic target one disability effort highlight explore issue exploratory study conducted learn rates abuse among university students identified disability cross sectional survey students students disabilities large northeastern public university experiences abuse measured use abuse assessment screen disability aas scale students asked experiences physical sexual psychological disability related abuse within last year help seeking behaviors incident abuse occurred found participants reported form abuse last nearly experienced form physical sexual abuse age abused past year reported little knowledge abuse related resources reported incident authors discuss implications results programs policies campus individuals disabilities
background applications mindfulness perinatal period recently explored appear offer decrease stress anxiety depression period however still remains unclear practical use women make mindfulness postpartum period mechanisms works subjective experience mindfulness practice mothers fully understood aim present study explore women enrolled mindfulness based childbirth parenting programme experienced mindfulness practice postpartum period methods ten pregnant women years age singleton pregnancies diagnoses mental illness participation mindfulness based childbirth parenting programme recruited take part postpartum interview audio recordings interviews transcribed analysed thematically based phenomenological approach transcripts nine interviews submitted coding process consisting identification words sentences paragraphs expressing common ideas ideas classified codes code representing specific description function action self perception personal organization formal informal meditation practice progressively framework thematic ideas extracted transcripts allowing interviews systematically organized content analysed depth results five themes emerged descriptions practices mindfulness postpartum period perception present moment breathing acceptance self compassion perception mindfulness shelter conclusion mindfulness practices postpartum period may contribute mother psychological wellbeing perception mindfulness shelter previously reported future research could address whether role specific postpartum period
magnetorheological fluid widely used smart material due outstanding properties paper presents design development modeling prototype testing self energizing self powered brake wire system whose aforementioned capabilities enabled brake energy harvesting system composed mainly typical shaped drum type brake wedge mechanism self energizing purpose system also install generator harvests regenerative energy braking thereby creating self power capability found common vehicular brake wire systems brake torque analysis conducted braking process simulated matlab simulink environment finite element analysis magnetic field temperature field mechanical strength critical components carried simulation results used optimize design parameters material selection finally prototypes corresponding test rig established experimental results show power required generate brake torque regenerative power produced generator used braking thus fulfilling self power requirement investigation different wedge angles indicates considerable self energizing occurs small wedge angle findings demonstrate brake actuator relatively small volume significantly enlarge brake torque harvesting brake energy feature enables promising application fluids automotive brake systems
paper proposes flexible control framework relational personal data enforces data originators dissemination policies inspired sticky policy paradigm mandatory access control dissemination policies linked atomic data combined different pieces data merged background setting relational provenance guarantees policy combining operations behave accordingly operations carried data show framework capture large class policies similar lattice based access control models integrated seamlessly relational database management systems particular define path oriented dissemination control model policies define authorized chains transfers databases promising ongoing research work include generalization theoretical framework expressive query languages including aggregation difference operators well experiments secure tokens
background guselkumab interleukin blocker superior adalimumab treating moderate severe psoriasis phase trial objectives sought compare efficacy safety guselkumab adalimumab placebo patients psoriasis treated year methods patients randomized guselkumab weeks every weeks placebo guselkumab weeks guselkumab weeks every weeks adalimumab week week every weeks week physician reported outcomes investigator global assessment psoriasis area severity index pasi patient reported outcomes dermatology life quality index psoriasis symptoms signs diary safety evaluated week results guselkumab superior placebo week investigator global assessment score cleared minimal greater improvement pasi score baseline pasi guselkumab also superior adalimumab investigator global assessment pasi week week week furthermore guselkumab significantly improved patient reported outcomes week adverse event rates comparable treatments limitations analyses limited weeks conclusions guselkumab demonstrated superior efficacy compared adalimumab well tolerated patients psoriasis year
physical training important strategy health people living hiv aids however short term responses yet extensively studied limits understanding effects safety training prescription population therefore aimed systematically review acute responses resulting physical exercise people hiv physiological immunological variables systematic review carried works indexed following databases medline lilacs scielo web science science direct keywords used acquired immunodeficiency syndrome hiv aids seropositive acute session short physical activity exercise training searches conducted february updated december conducted without restriction publication dates specific language included review articles evaluated acute responses derived model prescription physical training involving aerobic weight combined exercises aerobic weight exercises related physiological immunological variables hiv infected individuals found titles exclusion duplicates application eligibility criteria seven articles selected qualitative synthesis according results reported studies evidence immediately physical exercise increase number circulating cells occurs including total leukocytes neutrophils monocytes lymphocytes hiv infected people furthermore significant changes concentrations lactate triglycerides epinephrine norepinephrine also observed immediately aerobic training regardless use haart hyperlactatemia however insufficient evidence state physical training totally safe effective population
green infrastructure defined type infrastructure purpose lessening burden development environment aim providing ecosystem services runoff management air temperature reduction carbon sequestration habitat provisioning despite potential benefits recent increase popularity widespread use green infrastructure limited ascertain may case asked socio ecological factors influence adoption green infrastructure answer question carried review literature found papers addressing research topic three quarters published since based results conclusions articles reviewed identify six factors influence adoption green infrastructure education provision ecosystem services financial incentives coordination among actors laws policies planning recommendations present model direct indirect effects factor adoption green infrastructure investigate geographic variability factors results indicate education provision ecosystem services financial incentives influential factors affecting adoption green infrastructure supported greatest number articles regardless location study greatest number linkages factors adoption model conclude evidence based strategies promote use green infrastructure order create sustainable environments
paper investigates impact tolerances related permanent magnets cogging torque performance pmsms machines usually show considerable sensitivity regarding tolerances geometric dimensions material characteristics consistent approach presented order minimize computational effort evaluating sensitivity robustness reliability thereby design experiments used minimize required number finite element simulations work box behnken based approach considered subsequently surrogate modeling technique based second order equation applied consequence reduction computational cost achieved obtained results compared outcomes solely derived means finite element computations good agreement observed illustrated providing probability distribution cogging torque considered machine design addition cumulative distribution presented usually applied analyzing reliability considering analysis impact tolerances part optimization scenarios increases number designs analyzed least one degree magnitude obtained results look promising achieving feasible computational cost
background objectives depression major psychological sequelea hiv aids infection continued attract investigation studies nigeria unclear whether levels perceived stigma sexual risk behaviors anticipated discrimination differentially associated severity depression materials methods present study using multivariate design investigated role stigma anticipated discrimination self esteem hiv related factors drug use combination knowledge duration hiv diagnosis socio demographic factors multiple spouse age gender ethnicity depression among people living hiv aids plwha follow management three tertiary hospitals nigeria five hundred two males females hiv aids patients participated study results mean age mean time months since diagnosis respectively three variables ethnicity anticipated discrimination hiv related stigma related severity depression multinomial logistic regression analyses showed yoruba odds ratio confidence interval igbo extraction reduces risk reporting severity depression respectively moreover low perceived hiv related stigma low anticipated discrimination reduced risk reporting symptoms severe depression respectively conclusion intervention reduce severity depression consider cultural specificity design also evolve educational programs incorporate discrimination stigma managing depression among plwhas
curriculums must continuously tuned incorporating new advanced teaching materials order link educational institutions system society demand prepare students wide spectrum actualized knowledge valid century sense osmosis technologies proposed educational purposes especially practical trainings graduated undergraduated students different educational fields disciplines science engineering physics chemical engineering environmental materials engineering etc engineered osmosis emerging platform technology includes isothermal non isothermal membrane processes used production water energy includes isothermal processes forward osmosis pressure retarded osmosis pro reverse osmosis osmotic distillation non isothermal processes osmotic membrane distillation omd thermo osmosis membrane installation used perform processes changes membrane type necessary systems apply required driving force actual interests engineered applications osmosis spurred due recent advances progresses membrane science technology platform offers unique learning opportunity students many potential laboratory scenarios permitting explore theoretical experimental tests different membrane separation processes running different driving forces temperature concentration hydrostatic pressure partial vapour pressure general chemical potential difference sides membrane understand heat mass transport mechanisms different types membranes bring practice non equilibrium thermodynamics theory transport phenomena understand effects temperature polarization concentration polarization select hydrodynamic conditions flow regimes process etc
background objective study examine association low blood lead levels compared children dental caries risk dental caries according blood lead level estimated using zero inflated negative binomial model results geometric mean geometric standard deviation maximum blood lead level children level blood lead level significantly higher children without deciduous dental caries similarly permanent dental caries adjustment covariates deciduous teeth surfaces decayed filled increased significantly increasing blood lead levels dose dependent manner prevalence ratio confidence interval however risk dental caries permanent teeth linearly associated increase blood lead level conclusions sum decayed filled surfaces found significant increase risk dental caries deciduous teeth increase blood lead levels found statistical significance association decayed filled surfaces caries separately
paper presents model based control solution large inertia systems controlled fast digital hydraulic valve solution based model based force control shown cylinder chamber pressures first order dynamics proper parameter selection robust stability analyzed unknown load mass bulk modulus delay shown simple cascaded pid controller results good control performance robustness simulated results show smooth stable response good tracking performance despite large variations load mass bulk modulus
purpose paper aims report information security behaviors smartphone users affluent economy middle east design methodology approach model based prior research synthesized thorough literature review tested using survey data smartphone users representing three major mobile operating systems findings overall level security behaviors low regression coefficients indicate efficacy security measures cost adopting main factors influencing smartphone security behaviors present smartphone users worried malware data leakage targeted information theft research limitations implications threats counter measures evolve time findings describe state smartphone security current time need updated future practical implications measures improve security practices smartphone users needed urgently findings indicate measures broadly effective relatively costless users implement social implications personal smartphones joining enterprise networks acceptance bring device computing users laxity smartphone security thus puts organizations risk originality value paper highlights key factors influencing smartphone security compares situation three leading operating systems smartphone market
cerebral microbleeds cmbs mri markers attributed common cerebral angiopathies elderly patients dementia hypertensive cerebral amyloid angiopathy cmb detection asymptomatic persons may help identify risk dementia may influence preventive strategies design clinical trials testing treatments dementia studied association cmb risk incident dementia community dwelling individuals total dementia free framingham heart study participants mean age years women available brain mri incident dementia data mean follow period years included using cox proportional hazards models related cmb presence incident dementia multivariable models adjusted age sex apoe status education additional models adjusting vascular risk factors mri markers ischemic brain injury cmbs observed incident dementia participants study period participants cmb times higher risk dementia hazard ratio confidence interval whereas deep mixed cmb three fold increased risk associations independent vascular risk factors deep mixed cmb also independent mri markers ischemia purely lobar cmbs associated incident dementia findings support role hypertensive vasculopathy interplay hypertensive cerebral amyloid angiopathy risk dementia suggest cmb presence identify individuals risk dementia elsevier inc rights reserved
hybrid model perceived risk entrepreneurial opportunity introduced entrepreneurship recognition model paper linear regression algorithm introduced analysis correlation deviation error model based neural network algorithm design algorithm realized matlab toolbox error analysis convergence curve obtained matlab visualized analysis seen linear regression analysis precision higher hybrid recognition perceived risk entrepreneurial opportunity curve relevance entrepreneurial opportunities perceived risk obtained significance test found eventually related factors relationship entrepreneurs entrepreneurial opportunity recognition perceived risk significant
present protection ecological environment promotion green building recognized widely promoted rapid development construction industry architecture design inevitably require resentation unique form charm reflect ecological concept ecological culture unique nature art particularity environment establish ecological concept green building design vigorously develop green green building complementary role alleviate pressure resources speed eco city planning design realize sustainable development city protect urban ecological environmental
older adults mobilize social support without digital media investigate focus older adults residing toronto locality east york using interviews lasting minutes done find digital media help mobilizing social support well maintaining strengthening existing relationships geographically near distant contacts especially important individuals network members limited mobility older adults start using digital media become routinely incorporated lives used conjunction telephone maintain existing relationships develop new ones contradicting fears digital media inadequate meaningful relational contact found older adults considered social support exchanged via digital media real support dismissed token older adults especially used valued digital media companionship also used coordination maintaining ties casual conversations email used friends relatives skype used close family ties research suggests policy efforts need emphasize strengthening existing networks rather establishment interventions outside older adults existing ties findings also show learning master technology form social support provides opportunities strengthen networks older adults
objective chronic kidney disease ckd public healthcare issue reached epidemic proportions low levels public awareness early detection complicate timely treatment disease awareness rate patients ckd around worldwide turkey study aims emphasize importance public awareness pave way comprehensive studies material methods respondents chosen randomly various cities turkey replied survey survey consisted questions participants demographic information medical history daily liquid intake various habits previous instruction kidney health results findings indicate higher level education associated greater awareness health related subjects addition several factors known cause kidney damage long term identified among factors insufficient liquid intake refusal urinate outside home soft drinks unnecessary use drugs olive cheese consumption found especially prominent conclusion clear many factors quicken progression ckd present awareness levels quite poor findings reveal need conduction larger scale field research studies ckd
four decades studying human memory research concerns malleable nature memory information suggested individual event integrated memory event actually occurred discussed later may occurred become inextricably interwoven allowing distortion elaboration even total fabrication writings classes public speeches tried convey one important take home message someone tells something great detail much confidence emotion mean true describe professional life experimental psychologist eavesdropped process well many personal experiences may influenced thinking choices
increase maritime traffic particularly transport hazardous noxious substances hnss requires advanced methods identification characterization environmental chemical spills knowledge hns monitoring using radar remote sensing extensive oil spills however progress issue would likely advance monitoring chemical oil related incidents address need hns monitoring experiment conducted may mediterranean sea controlled releases hns imaged multifrequency radar system aim experiment establish procedure collecting evidence illegal maritime pollution noxious liquid substances using airborne radar sensors paper demonstrate ability radar imagery detect characterize chemicals sea normalized polarization difference parameter introduced quantify impacts released product ocean surface relative concentration substance within spill show radar imagery provide knowledge involved hns particular one distinguish product forms film top sea surface another mixes seawater information critical efficient cleanup operations
success failure operating rainwater harvesting system rwh depends technological non technological factors importance non technological factors attaining sustainable rwh operation rarely emphasized study aims assess contribution non technological factors determining decisive factors involved use rwhs agriculture irrigation beijing rwhs agriculture irrigation beijing operating well expected decisive factors identified non technological significance non technological factors highlighted firstly impact factors comprising non technological technological factors selected according literature review interviews rwh managers following artificial data mining method rough set analysis decisive factors identified results show two non technological factors doubts rainwater quality availability groundwater determine whether systems continue cease rwh operation beijing thus considered necessary improve public confidence motivation using rainwater agriculture irrigation main obstacle sustainable successful operation rwhs case study rwhs beijing study verifies importance acknowledging non technological factors achieve sustainable water management considers factors receive attention decision makers researchers
purposemagnetic susceptibility physical property matter varies depending chemical composition abundance different molecular species interest growing mapping magnetic susceptibility human brain using magnetic resonance imaging techniques influences affecting mapped values fully understood methodswe performed quantitative susceptibility mapping tesla multiple echo time gradient recalled echo data evaluated trend regions human brain temporal plots susceptibility performed caudate pallidum putamen thalamus insula red nucleus substantia nigra internal capsule corpus callosum fornix implemented existing three compartment signal model used optimization fit experimental result assess influences could responsible findings resultsthe temporal trend susceptibility different different brain regions subsegmentation specific regions suggests differences likely attributable variations tissue structure composition using signal model verified nonlinear temporal behavior experimentally computed susceptibility within imaging voxels may result heterogeneous composition tissue properties conclusionsdecomposition voxel constituents meaningful parameters may lead informative measures reflect changes tissue microstructure magn reson med international society magnetic resonance medicine
background meconium stained amniotic fluid msaf common occurrence among women spontaneous labor term associated adverse outcomes mother neonate msaf risk factor microbial invasion amniotic cavity miac preterm birth among women preterm labor intact membranes report frequency miac presence bacterial endotoxin amniotic fluid patients msaf term materials methods conducted cross sectional study including women presumed preterm labor uncertain dates underwent amniocentesis later determined term patients allocated two groups msaf clear amniotic fluid presence bacteria determined microbiologic techniques endotoxin detected using limulus amebocyte lysate lal gel clot assay statistical analyses performed test normality bivariate comparisons results bacteria frequently present patients msaf compared clear amniotic fluid versus microorganisms gram negative rods ureaplasma urealyticum gram positive rods mycoplasma hominis lal gel clot assay positive patients msaf clear amniotic fluid heat treatment frequency positive lal gel clot assay remained higher msaf group versus median amniotic fluid concentration higher versus median amniotic fluid glucose concentration lower versus msaf group clear amniotic fluid conclusion msaf term associated increased incidence miac index suspicion infection related process postpartum women neonates increased presence msaf
adult hippocampal neurogenesis strongly impaired alzheimer disease several mouse models shown adult born neurons exhibit reduced survival altered synaptic integration due severe lack dendritic spines present work using appxps mouse model reveal reduced number spines concomitant marked deficit neuronal mitochondrial content remarkably show targeting overexpression pro neural transcription factor neurodl appxps adult born neurons restores dendritic spine density also mitochondrial content proportion spines associated mitochondria using primary neurons bona fide model neuronal maturation identified increases mitochondrial respiration accompany stimulating effect neurodl overexpression dendritic growth spine formation reciprocally pharmacologically impairing mitochondria prevented neurodl dependent trophic effects thus since overexpression neurodl new neurons appxps mice rescues spatial memory present data suggest manipulating mitochondrial system adult born hippocampal neurons provides neuronal plasticity brain findings open new avenues far reaching therapeutic implications towards neurodegenerative diseases associated cognitive impairment elsevier inc rights reserved
managed patient epstein barr virus associated cell lymphoblastic lymphoma mediastinal tumor cells initial admission positive tdt interestingly lymph node necropsy compatible positive peripheral cell lymphoma without tdt expression suggesting different phenotype mediastinal tumor tumor cells pleural effusion continued proliferate vitro designated cells positive cell receptor tcr alpha beta tdt indicating similar phenotype thymocytes southern blot analyses showed pleural tumor cells shared tcr gene rearrangement contained clonal ebv genome episomal form pcr showed ebna lmp expressed fresh tumor cells southern blot analyses revealed cells susceptible ebv infection vitro using supernatant anti antibody inhibited vitro infection ebv suggesting plays role ebv infection cells vitro infection ebv affect latent gene expression cells useful tool analyzing roles ebv onocogenesis immature lymphoid malignancies elsevier ltd rights reserved
purpose article analyze persuasive preventing actions social workers carried radial stations plata city actions put pressure gender roles established duties professional performance based two wider interests first recover rethink social working history understanding social workers beyond medical prescriptions gender roles secondly article considers relevance local narrations generate points view women participation history social working first part article introduces characteristics school social workers hygiene university plata second section focused participation social workers hygiene radial conference speakers
paper simple efficient watermarking method proposed using visual cryptography singular value decomposition chaotic maps proposed scheme uses gray level image watermark instead binary logo bit sequence proposed scheme zero watermarking scheme watermark embedded directly host image host image encrypted secret watermark image constructing two shares master share ownership share two shares separately give information watermark stacked together watermark revealed singular value decomposition used select robust features host image chaotic maps used improve security experimental study conducted evaluate robustness algorithm various signal processing geometrical attacks
study evaluated concentration der der blo fur households dogs atopic dermatitis healthy dogs diagnosis clinical based favrot criteria dust samples collected domestic vacuum cleaner site vacuumed min samples collected separate filters transferred plastic containers sealed kept frozen elisa analysis fur atopic dogs average concentration der compared healthy dogs households atopic dogs highest concentrations der found carpets followed couches beds dogs bed linen floors concentrations der carpets couches beds significantly higher atopic dogs fur concentrations der der blo equivalent atopic non atopic dog households among allergens studied der commonly found predominantly carpets couches
using mixed design analysis variance paper examines effect body art job applicant hireability ratings employs literatures social psychologies stigma prejudice well aesthetic labor frame argument results indicate photos tattooed pierced job applicants result lower hireability ratings compared control faces negative effect body art employment chances however reduced job applicants seeking non customer facing roles customer facing roles tattoo associated lower hireability ratings piercing results suggest visible body art potentially real impediment employment wiley periodicals inc
homogeneous complete combustion internal combustion engines advantageous use porous foam exhaust gas engine cylinder heat recovery examined aim reducing engine emissions internal combustion engine porous core regenerator modeled using sopht software solved differential equations thermal circuit engine engine thermal efficiency observed increase porous core regenerator applied raising compression ratio causes peak pressure thermal efficiency increase increasing compression ratio causes thermal efficiency output work increase respectively regenerator also used catalytic converter fine particles emissions regenerator oxidizes unburned hydrocarbons meanwhile heat recovered exhaust gases reduce fuel consumption reducing pollutant emissions internal combustion engine
since advent nano materials unique mechanical properties chemical properties concern many experts scholars describes application research results recent years nano materials construction industry adding nano materials ordinary concrete improve performance concrete including strength toughness durability properties recent years increase number nano materials researchers nano materials use construction industry also better understanding yet fully grasp mechanism action need depth research exploration
reviewed meta analyzed studies examined association risk child maltreatment perpetration basal autonomic activity studies examined association risk child maltreatment autonomic stress reactivity hypothesized maltreating parents risk adults would show higher basal levels heart rate skin conductance lower levels variability hrv would show greater stress reactivity blunted hrv reactivity narrative review showed evidence significance testing within across studies mixed first set meta analyses revealed risk child maltreatment associated higher baseline activity possible indication allostatic load second set meta analyses yielded differences autonomic stress reactivity maltreating risk participants nonmaltreating low risk comparison groups cumulative meta analyses showed positive effects sympathetic stress reactivity risk factor child maltreatment found early studies whereas subsequently aggregated study reduced combined effect size null effect indication winner curse studies underpowered future directions research suggested
background health policy guidelines standards advocate giving patients comprehensive information facilitating involvement health related decision making routine assessment patient reports processes needed objective examine decision making processes specifically information provision consumer involvement decision making nine pregnancy labour birth procedures reported maternity care consumers queensland australia methods participants women live birth queensland specified time period found baby died since birth completed extended baby queensland survey maternity care experiences reported least one nine procedures interest procedure women answered two questions measured perceived receipt information benefits risks procedure role decision making procedure results eligible women completed survey pre labour caesarean section vaginal examination women reported informed benefits risks procedure experienced epidural episiotomy women reported unconsulted decision making one quarter women experienced episiotomy reported neither informed consulted conclusions urgent need interventions facilitate information provision consumer involvement decision making several perinatal procedures especially performed within time limited intrapartum care episode
water distribution networks vulnerable various contamination events may accidental purposeful sensors required online monitoring water quality safeguard human health since sensors costly numbers must limited makes sensor locations crucial water monitoring system paper aims location sensors intermittent water distribution system prone accidental contamination due contaminants ingress pipe lines low pressures non supply hours considering deployment limited number sensors novelty paper propose methodology selection contamination events associated risk used design sensor network integrated risk assessment model used identify risk prone areas may lead possible contamination events genetic algorithm based methodology suggested optimal location water quality sensors maximize detection likelihood contamination events within acceptable time risk prone areas improve network security comparison sensor network design made considering contamination events occurring equal probability nodes equal probability risk prone nodes iii probability occurrences based quantified risk show identification risk prone areas selection contamination events results reduction computational work sensible placement sensors
catechol methyltransferase comt enzyme plays major role catechol neurotransmitter deactivation inhibition comt increase neurotransmitter levels provides means treatment parkinson disease schizophrenia depression comt exists two isozymes soluble cytoplasmic form comt expressed liver kidneys membrane bound form comt found mostly brain report backbone chemical shift assignments comt complex adenosyl methionine dinitrocatechol assignments obtained heteronuclear multidimensional nmr spectroscopy total backbone resonances assigned complex possible residues assigned trosy spectrum prediction solution secondary structure chemical shift analysis using talos webserver good agreement published ray crystal structures
morphological attribute profiles multilevel decompositions images obtained sequence transformations performed connected operators extensively employed performing multiscale region based analysis large number applications one main still unresolved issue selection filter parameters able provide representative non redundant threshold decomposition image paper presents framework automatic selection filter thresholds based granulometric characteristic functions gcfs gcfs describe way non linear morphological filters simplify scene according given measure since attribute filters rely hierarchical representation image tree shapes implementation gcfs efficiently computed taking advantage tree representation eventually study gcfs allows identification meaningful set thresholds therefore trial error approach necessary threshold selection automating process turn decreasing computational time shown redundant information reduced within resulting profiles problem high occurrence regards manual selection proposed approach tested two real remote sensing data sets classification results compared strategies present literature
investigation paper discrete integrable ablowitz ladik equation certain applications electrical optical systems via hirota method symbolic computation bilinear forms bright soliton solutions obtained propagation interaction behaviors discrete solitons analyzed one two soliton solutions discreteness effects soliton soliton interaction discussed asymptotic analysis shows interactions two solitons elastic head overtaking interactions obtained choices directions velocities two kinds overtaking interactions investigated analytically graphically respectively elsevier ltd rights reserved
purpose aim study present study investigated link hyperlipidemia inflammation oxidative stress cardiovascular risks subclinical hypothyroidism sch materials methods enrolled subclinical hypothyroid patients healthy subjects control autonomic functions assessed spectral analysis heart rate variability hrv continuous blood pressure variability bpv measurement conventional autonomic function testing thyroid profile lipid profile immunological inflammatory markers estimated correlated baro reflex sensitivity brs marker sympathovagal imbalance svi risk results mean arterial pressure map total peripheral resistance tpr ratio low frequency high frequency power hrv ratio significantly higher brs significantly lower sch group control group brs significantly correlated heart rate map ratio lipid risk factors anti thyroperoxidase antibody thyroid stimulating hormone high sensitive reactive protein hscrp malondialdehyde mda sch conclusions concluded svi associated sch though dyslipidemia inflammation contributed decreased brs sch per contributed maximally decreased brs could physiological basis increased risks patients sch
paper present models code acquisition process rake receivers models include multipath diversity multiple transmitter base station satellite diversity multiple access interference generated users network results different probability false alarm cell code delay uncertainty region analysis based signal flow graph theory using models elaborate different strategies rake receiver synchronization derive exact closed form results average acquisition time strategies differ organize initial first rake finger postinitial search algorithms channel known initial synchronization may organize parallel search fingers simultaneously proper set local correlators mutual delays serial search different segments partitioned among different fingers organized postinitial search sequential random initializations possible set approximations also included practical applications quick assessment system performance needed
objective evidence parents play important role adolescent health well links specific daily processes biological mechanisms relevant health remain determined study examined role parental accuracythat whether parents accurate adolescents daily experiences adolescents better psychological functioning inflammatory regulation methods week daily diary study parent adolescent dyads examined whether parental accuracy adolescent daily demands positivity day together associated markers psychological functioning regulation inflammatory response terms glucocorticoid sensitivity extent cortisol able dampen production inflammatory proteins adolescents results adolescents whose daily experiences perceived accurately parents reported better psychological adjustment lower stress depression greater sensitivity immune cells anti inflammatory signals cortisol diminished production inflammatory proteins cells stimulated combination bacterial product lipopolysaccharide cortisol range values conclusions greater parental accuracy regarding adolescents daily experiences associated better adolescent psychological adjustment sensitive anti inflammatory response cortisol results provide preliminary evidence parental accuracy regarding adolescent daily experiences may one specific daily parent factor plays role adolescent health well
product lifecycle management plm systems provide useful function regard creating managing product data current plm systems based individual functions distributed information management takes lot time effort collect data well analyse engineering planning data therefore difficult achieve integrated engineering environment share information across departments enterprises environment current plm systems moreover current plm systems concentrated design engineering design production management design data manufacturing engineering layout design focal point current plm systems hence achieve integrated concurrent engineering environment authors propose new concept digital factory wizard dfw plm environment dfw provides interoperability across heterogeneous systems integrated information management well facilitates information utilisation based concept proposed research dfw composed four modules integrated standard schema iss plm integrator layout builder simulation builder iss defines common data type structure supporting interoperability supporting automatic information exchange iss plm integrator developed third module helps generate factory layout using managed information plm systems finally function automatic generation simulation model final part article suggests implementations presents case study show implementation effective reliable interoperable engineering environment possible performed concurrent integrated manner
charmin first actuated exoskeleton robot pediatric arm rehabilitation device specifically designed provide intensive rehabilitative training children affected arm motor function due cerebral palsy therewith complementing conventional therapies paper gives comprehensive overview charmin robot provides six actuated degrees freedom designed cover complete target group children adolescents aged years moreover new audiovisual game like interface presented motivates active participation child support child arm movements exoskeleton patient cooperative control strategy implemented controller enables free arm movements assistance asneeded complete guidance arm five children aged years impaired arm motor function due cerebral palsy stroke traumatic brain injury tested various training scenarios different amounts support robot settings depending therapeutic goals children movement capabilities preferences preliminary tests suggest charmin setup used advanced exercise tool arm neurorehabilitation optimally challenges children adolescents severely tomoderately affected armmotor functions
lung cancer leading cause cancer death worldwide tobacco use remains single important preventable cause cancer responsible cases lung cancer implementation tobacco control measures including preventing initiation treating dependence pivotal address lung cancer epidemic new evidence continues emerge significant positive impact incorporating tobacco dependence treatment within lung cancer treatment protocols evidence guidelines implement strategies exist present opportunity nurses make difference reducing suffering preventing deaths lung cancer
objective examine associations sexual behaviour sexual function sexual health service use individuals depression british general population inform primary care specialist services setting british general population participants men women aged years interviewed third national survey sexual attitudes lifestyles natsal undertaken using age adjusted ors aaor relative comparator group reporting treatment symptoms compared sexual health reporting treatment depression past year outcome measures sexual risk behaviour sexual function sexual satisfaction sexual health service use results participants reported treatment depression men women relative comparator group treatment depression associated reporting sexual partners without condoms men aaor women concurrent partnerships men women past year reporting depression treatment likely dissatisfied sex lives men women score lowest quintile natsal sexual function measure also likely report recent chlamydia test men women sought help regarding sex life healthcare professional men women commonly family doctor women likely report attending sexual health clinic use emergency contraception associations broadly similar individuals depressive symptoms reporting treatment conclusions depression measured reported treatment strongly associated sexual risk behaviours reduced sexual function increased use sexual health services many people reporting help family doctor sexual health depressed people needs consideration primary care mental health assessment might benefit people attending sexual health services
purpose pro antiinflammatory cytokines important modulators immune response play major role conditions intestinal inflammation irritable bowel syndrome ibs cytokine production regulated genetically imbalances cytokine secretion may affect disease susceptibility clinical outcomes various conditions rapidly growing body evidence support etiologic role gastrointestinal infection associated immune activation development postinfectious ibs factors psychological stress anxiety depression may likely involved altered profiles pro antiinflammatory cytokines lead chronic ibs methods searched literature using pubmed medline google scholar related key terms prepared review article basis findings interleukin regulatory cytokine inhibits antigen presentation release proinflammatory cytokines therefore proposed potent antiinflammatory biological therapy ibs implications recently strong interest therapeutic potential ibs developed diverse roles ibs reviewed conducted depth review ibs address question future studies may provide new insights ibs therapy elsevier journals inc rights reserved
purpose infection malignancy represent two common complications solid organ transplantation often characterized poorly specific clinical symptomatology herein evaluated role fluoro deoxy glucose fdg positron emission tomography computed tomography pet clinical setting methods fifty eight consecutive patients underwent fdg pet kidney lung heart transplantation included retrospective analysis twelve patients underwent fdg pet strengthen confirm diagnostic suspicion malignancies remaining patients presented unexplained inflammatory syndrome fever unknown origin fuo cmv ebv seroconversion post transplant follow without conclusive conventional imaging fdg pet results compared histology finding obtained clinical imaging follow period least months pet study results positive fdg pet results obtained patients remaining cases fdg pet negative showing exclusively physiological radiotracer distribution basis patient based analysis fdg pet sensitivity specificity ppv npv respectively global accuracy fdg pet true positive patients bacterial pneumonias pulmonary fungal infection histoplasmosis cutaneous abscess inflammatory disorder sacroiliitis lymphoma nsclc hand fdg pet failed detect lung bronchoalveolar adenocarcinoma septicemia endocarditis graft versus host disease gvhd respectively four patients fdg pet contributed adjusting patient therapeutic strategy cases conclusions fdg pet emerges valuable technique manage complications post transplantation period fdg pet considered patients severe unexplained inflammatory syndrome fuo inconclusive conventional imaging discriminate active silent lesions previously detected conventional imaging particularly malignancy suspected
atopic dermatitis common inflammatory condition skin usually seen childhood onset persist adulthood characteristic distribution morphology based age chronic relapsing course pruritus comprise clinical criteria used diagnosis however numerous morphologies ranging acute weeping erythematous papules chronic lichenified plaques simulated multiple conditions including inflammatory infectious neoplastic photo dermatoses recognition distinguishing features clinical mimickers atopic dermatitis vital accurate timely diagnosis initiation proper treatment regimens
low power one key driving forces modern large scale integration systems recent studies show integrated circuits ics offer significant power saving ics however studies mainly limited two tier tier designs thus paper extend target three tier tier ics paper first shows one additional tier available tier ics offer power saving compared tier counterparts careful floorplanning silicon via management block folding considerations required second find tiers bonded several different ways face back face face face back combined back back face face combined paper shows choices pose additional challenges design optimizations power saving lastly develop effective computer aided design solutions seamlessly integrated commercial tools handle tier power optimization various bonding style options low power design methods combined tier ics provide power reduction tier ics ics microprocessor cores performance full chip microprocessors tier ics provide power reduction ics
objective examine association postmenopausal hormone therapy alzheimer disease methods medicine alzheimer disease medalz nested case control study entire finnish population clinically verified matched controls per case study comprises women cases controls data use extracted national prescription register using following atc codes goc estrogen god progestogen gof estrogen progestogen combination systemic oral transdermal considered results use systemic estrogen progestogen associated increased risk ors respectively use systemic estrogen years protective long term years use progestogen combination related risk conclusion findings suggest important determinant risk elsevier rights reserved
body image disturbances prominent feature eating disorders eds aim test evaluate computerized assessment body image cabi compare body image disturbances different types assess factors affecting body image body image individuals undergoing inpatient treatment restricting anorexia nervosa binge purge bulimia nervosa healthy controls assessed using contour drawing rating scale cdrs cabi simulated participants self image different levels weight changes eating disorder inventory body dissatisfaction edi scale severity depression anxiety also assessed significant differences found among three scales assessing body image although dimensions differentiated patients eds controls findings support use cabi comparison body image disturbances patients eds controls moreover use different assessment tools allows better understanding differences body image disturbances different types
report multifunctional four finger gripper soft robotics suitable performing delicate manipulation tasks gripping device comprised separately driven gripping lifting mechanisms made separate single piece smart material ionic capacitive laminate icl also known artificial muscle compared similar devices relatively high force output icl material allows one construct device able grab lift objects exceeding multiple times weight due flexible design icl grips device able adapt complex shapes different objects allows grasping single multiple objects simultaneously without damage performance gripper evaluated two different configurations ultimate grasping strength gripping hand maximum lifting force lifting actuator icl composed three main layers porous membrane consisting non ionic polymer poly vinylidene fluoride hexafluoropropene pvdf hfp ionic liquid ethyl methylimidazolium trifluoromethane sulfonate emitfs reinforcing layer woven fiberglass cloth sides membrane coated carbonaceous electrode electrodes additionally covered thin gold layers serving current collectors device made material operates silently requires low driving voltage suitable performing tasks open air environment
composite materials composites engineered naturally occurring materials made two constituent materials significantly different properties remain separate distinct macroscopic microscopic scale even made single material constituent materials used compensate limitations resulting material would constitute advantages included materials therefore combining specific materials would achieve material could serve specific application extensively days composite materials plays wide extensive role manufacturing engineering components several types composite materials methods manufacturing paper manufacturing metal matrix composites stir casting taken focus manufacturing aluminium alloy sic particle reinforced mmc stir casting objective widely used automotive aeronautical application given prime importance methodology opted manufacturing stir casting cheapest easiest applications like automotive aeronautics involves manufacturing utilization large number components price low process easy simple lot researches going area varying different parameters paper focuses designing fabricating testing different stirrers feeders utilizing stir casting manufacturing aluminium silicon carbide composite materials significance individual stirrers feeders compared best one identified significance stirrer feeder found testing specimen elsevier ltd
cavitation distribution high intensity focused ultrasound sonoreactors hifu extensively described recent literature including quantification optical method sonochemiluminescence scl present paper provides complementary measurements study acoustic streaming generated kind hifu transducers end results mass transfer measurements electrodiffusional method compared optical method ones particle image velocimetry last one used various configurations without electrode acoustic field order perturbation wave propagation results show maximum velocity located focal shifted near transducer shift greater high powers two cavitation modes stationary moving bubbles greatly affect hydrodynamic behavior sonoreactors acoustic streaming fluid generated bubble motion results obtained electrochemical measurements show low hydrodynamic activity transducer vicinity shift active focal toward transducer absence activity post focal axial zone comparison theoretical eckart velocities acoustic streaming non cavitating media confirms high activity sonochemical focal accounted wave distortion induced greater absorption coefficients moreover equivalent liquid velocities one order magnitude larger ones measured ply confirming enhancement mass transfer bubbles oscillation collapse close surface rather pure streaming effect elsevier rights reserved
paper result development web application register annual work program goals actions assigned financial resources manage annual work program identified paper identified five types users first administrator charge monitoring goals programmed period well resource assigned reach goals second corresponds purchasing department charge contacting supplier time inform financial warehouse acquisition system third corresponds warehouse charge validating material generate entry exit official vouchers send purchase order financiers fourth user corresponds financial identify system procedure completed make payment finally fifth user make set remaining departments finally system presents flexibility case necessary adding departments
painting light user guided interactive evolutionary system daylighting design allows architects use color specify desired light levels spaces searches solutions bring building geometry materials close performance targets proposed interface addresses main limitation generative design systems based building performance metrics allowing user specify daylight spatial patterns high degree granularity development poses new challenges objective function penalty function definitions painting light automatically computes displays statistical indexes inform user deviation error performance solution found system desired targets system implemented python top popular computer aided design software rhinoceros add visual programming language grasshopper choice implementation allows access grasshopper built functions methods parametric modeling tools provide direct access radiance lighting simulation software different types genetic algorithms five experiments conducted freeform parametric model progressive system calibration encompassed four steps adjustment painted targets fit problem feasible solution space devise appropriate weights penalty factors fitness function test two different evolutionary solvers test system capability find predefined solution optimal values known calibration system able produce solutions closely approximate painted goals elsevier ltd rights reserved
pid controller widely used many different areas power systems drives control automotive mechatronics aerospace process control robotics recently fpga field programmable gate array become alternative solution realization digital control algorithm systems paper fpga based incremental pid proportional integral derivative controller designed simulated analysis pid control algorithm veriloghdl language used design software programs simulation results show effectiveness feasibility proposed method
background parkinson disease patients long term levodopa dopa treatment suffering severe circadian dysfunction however hard distinguish circadian disturbance patients due disease progression affected dopa replacement therapy study investigate role dopa circadian dysfunction rat model methods rat model constructed bilateral striatal injection hydroxydopamine ohda followed administration saline dopa consecutive days rotarod test footprint test open field test carried evaluate motor function striatum suprachiasmatic nucleus scn liver plasma collected quantitative real time polymerase chain reaction used examine expression clock genes enzyme linked immunosorbent assay used determine secretion level cortisol melatonin high performance liquid chromatography used measure neurotransmitters analysis variance used data analysis results dopa alleviated motor deficits induced ohda lesions footprint open field test respectively dopa treatment bmall decreased scn compared ohda group melatonin inhibited dopatreatment conclusions circadian system advanced rat models circadian dysfunction contributed degeneration disease also long term dopa therapy may aggravate
nmda receptors nmdars ionotropic glutamate receptors crucial neuronal development higher cognitive processes nmdar dysfunction involved variety neurological psychiatric diseases however mechanistic link human pathology nmdar dysfunction poorly understood rare missense variants within nmdar subunits identified numerous patients mental neurological disorders specifically focused glunb nmdar subunit highly expressed hippocampus cortex throughout development analyzed several variants located glunb terminus found three variants patients autism schizophrenia rodents respectively displayed impaired binding membrane associated guanylate kinase maguk proteins addition observed deficit surface expression glunb furthermore fewer dendritic spines glunb expressing neurons importantly synaptic nmdar currents neurons transfected glunb gluna deficient mouse brain slices revealed partial rescue synaptic current amplitude functional properties glunb recombinant systems revealed change receptor properties consistent synaptic defects result reduced trafficking targeting glunb synapse therefore find glunb displays deficits nmdar trafficking synaptic currents spine density raising possibility mutationmaycontribute phenotype autism patient morebroadly research demonstrates targeted study certain residues nmdars based rare variants identified patients powerful approach studying receptor function
study proposes tests new model seeks explain associations religion spirituality health outcomes among adolescents specifically test mediating effects perceived spirituality religion health relations using data study positive youth development find perceived spirituality mediates religion health relations varies based youths conceptualisation spirituality findings confirming perceived spirituality potentially promote youths psychosocial health offer future research directions implications regarding relations youths spirituality religion health behaviours
satellite good communication system disaster recovery civil protection operations however reliability communication must ensured respect operative scenario faced major parameter concerning reliability satellite link outage probability time per year link mainly depends occurrence rain attenuation along radio path commercial systems customary accept means hours per year consider communication system facing flood hours exactly system required operate reason system requirements must rethought moreover lower frequency bands virtually immune radio attenuation crowed expensive require larger antennas makes sense explore possibility reliable weather communication using higher bands namely sensitive attenuation less expensive research performed cooperation eutelsat italian civil protection department italian fire department address issues first step analyze rain measurements taken meteorological radar relevant rain events order estimate actual rain attenuation experienced real operative scenario second step set mobile satellite radio link band stress suitability band weather emergency communication research shown values attenuation experienced band guarantee less expensive alternative emergency purposes band remains unreliable least without use next generation regenerative satellites paper also shows system dimensioning reliable use band
temperature one basic biophysical quantity monitored various biomedical systems moreover variation temperature also important parameter used estimating measurands respiratory airflow paper proposes simple operational amplifier based astable multivibrator circuit linearization characteristic negative temperature coefficient thermistor constituting one timing resistors circuit combined lookup table get unknown temperature value multivibrator output moreover system topology used linearizer measurement respiratory airflow performance composite system verified experimentally linearity approximately achieved degrees degrees case temperature measurement airflow lpm better results also achieved introduction interpolation algorithms higher computational component cost compactness complete system makes good candidate embedded sensing applications biomedical systems point care monitoring sleep study
pid controller widely used industries control applications tuning pid controller much essential implementation different methods pid tuning ziegler nichols tuning method internal model control method cohen coon tuning method tyreus luyben method chein hrones reswick method etc focus work paper identify system model flow control loop implement pid controller matlab simulation study labview real time experimentation comparative study three tuning methods viz imc carried work appropriately tune pid parameters flow control loop interfaced computer via daq card pid implemented using labview simulation real time results show imc tuning method gives better result tuning methods
relative general population individuals psychotic disorders higher risk suicide suicide risk also elevated criminal offenders thus psychotic disordered individuals antisocial tendencies may form especially high risk group built upon prior risk analyses examining whether neurobehavioral correlates social cognition associated suicidal behavior criminal offenders psychotic disorders assessed empathic accuracy brain structure four groups incarcerated offenders psychotic disorders past suicide attempts incarcerated offenders psychotic disorders suicide attempts iii incarcerated offenders without psychotic disorders community non offenders without psychotic disorders established suicide risk variables examined along empathic accuracy gray matter brain regions implicated social cognition relative groups offenders psychotic disorders suicide attempts lower empathic accuracy smaller temporal pole volumes empathic accuracy temporal pole volumes significantly associated suicide attempts independent risk variables results indicate brain behavioral correlates social cognition may add incremental value models suicide risk
premature failure expansion joints concern bridge owners opening traffic jiangyin suspension bridge experienced frequent damage expansion joints problem remained unsolved even replacement new expansion joints installation viscous dampers girder end paper aims clarify failure mechanism expansion joints based field test results field tests consist three scenarios static test influence line test truck pass test tests aimed investigate behavior expansion joints global local scales static influence line tests found strain response expansion joint affected girder deformation reflects effect global behavior bridge expansion joints truck pass test result shows direct impact heavy truck axles could induce high strain expansion joints indicates expansion joints affected vehicle axle loading local scale results accordance premature failures observed expansion joints jiangyin bridge american society civil engineers
hierarchical structures also known fractal structures exhibit advantageous material properties water oil repellency well useful optical characteristics owing self similarity various methods developed producing hierarchical geometrical structures recently fractal structures manufactured using printing technique involves computer aided design data study confirmed accuracy geometrical structures koch curve like fractal structures zero three generations printed using printer fractal dimension analyzed using box counting method analysis indicated fractal dimension third generation hierarchical structure approximately ideal koch curve findings demonstrate design production fractal structures controlled using printer although interior angle deviated ideal value side length could precisely controlled
paper proposes new cryptosystem system combines dna cryptography algebraic curves defined different galois fields security proposed cryptosystem based combination dna encoding compression process using hyperelliptic curve galois field coding via algebraic geometric code built using hermitian curve galois field proposed cryptosystem resists newest attacks found literature linear relationship original data information encoded hermitian code work factor attacks increases proportionally number possible choices generator matrix hermitian code simulations terms ber signal noise ratio snr included evaluate gain transmitted data awgn channel performance dna cryptosystem scheme compared coded qpsk mceliece code terms ber proposed dna system outperforms security level mceliece algorithm
mission command command philosophy denotes decentralized leadership philosophy command requires facilitates initiative levels command encourages subordinates exploit opportunities empowering demonstrate initiative exercise personal judgement first decades existence military analysts portrayed israeli command system termed optional control primary objective article explore rise decline optional control idf first part article follows development optional control idf first decades existence second part paper describe decline analysis command recent idf military campaigns last part analysis explanation decline mission command attributed four major factors changes israel society thereof civilmilitary relations changes character military operations lack appropriate military education role impact new technologies idf combined effect factors impedes ongoing efforts idf establish mission command preferred command philosophy
background central nervous system cns proteincoupled receptors gpcrs fruitful targets neuropsychopharmacological drug development rhodopsin class studied class gpcr includes orphan receptors endogenous ligand known unclear characterization orphan gpcrs proven challenging production pace gpcr based drugs incredibly slow objective determination functions receptors may provide unexpected insight physiological neuropathological processes advances various methods techniques investigate orphan receptors including situ hybridization knockdown knockout showed extensive expression receptors mammalian brain unmasked physiological neuropathological roles due rapid progress development orphan gpcrs rising new promising class drug targets neurodegenerative diseases psychiatric disorders conclusion review presents neuropsychopharmacological perspective orphan receptors rhodopsin class family namely gpr gpr gpr gpr gpr gpr gpr gpr gpr gpr gpr gpr gpr gpr gpr gpr gpr gpr gpr gpr gpr gpr gpr gpr gpr taar discussed expression receptors mammalian brain physiological roles furthermore briefly highlighted roles neurodegenerative diseases psychiatric disorders including alzheimer disease parkinson disease neuroinflammation inflammatory pain bipolar schizophrenic disorders epilepsy anxiety depression
paper survey known including recent results properties longest edge section algorithms algorithms classical recently designed conforming form nowadays used many applications including finite element simulations computer graphics etc reliable tool controllable mesh generation addition present list open problems arising around topic elsevier rights reserved
background study aims identify met unmet needs according patient carer staff relationship socio demographic clinical characteristics elderly people mental health problems methods sample elderly patients years sexes diagnosed mental illness icd criteria recruited inpatient outpatient settings department psychiatry mental health northern portugal patients assessed camberwell assessment need elderly cane results majority diagnoses depression dementia schizophrenia patients main unmet needs found psychological distress daytime activities benefits patients reported significantly lower unmet global needs carers staff respectively larger number global needs met unmet associated diagnosis dementia followed schizophrenia bipolar depressive disorder inpatients reporting needs outpatients conclusions mental disorders associated greater number needs elderly patients makes assessment important includes patients perspective focus intervention order decrease distress make beneficial use services especially inpatient settings different perspectives crucial assessing planning psychiatric mental health services
paper acquaints created application generating rainbow tables results testing rainbow tables according length chosen chain paper presents specialized application containing algorithms reduction functions changing length chain generating rainbow tables measuring effectivity password search detail within executed tests dependence rainbow tables size password length affection hash search size chosen chain links collisions arise principle using reduction function observed results objectively describe pros cons using rainbow tables show possibilities restrictions effective usage
guadua angustifolia species bamboo exhibiting excellent mechanical properties axial direction extensively investigated studies measured anisotropic constants necessary reliable theoretical analyses simple new protocol proposed determine circumferential axial shear modulus axial young modulus bamboo species loading slats torsion bending different theoretical formulations considered correlate experimental data circumferential axial shear modulus determined using torsion formula strength materials orthotropic finite element model axial young modulus obtained using strength materials formula higher determined using finiteelement orthotropic isotropic functionally graded models shear axial moduli obtained strength materials formulae provided relatively good estimates beam deflections protocol applied assess mechanical properties species bamboo wood used structural engineering practice
transport sector one main sources greenhouse gases adding spain near quarter total national emissions majority road transport therefore road contribution climate change mitigated achieve proposed goals fight climate change policies strategies suggest several preventive mitigation options paid little attention compensatory mitigation conducted theoretical case study spanish province segovia estimating carbon dioxide emissions road network analysing different compensation possibilities conservation agriculture agroforestry afforestation hedgerow plantation calculated carbon sequestration reference period costs per tonne option estimating budget range offsetting road carbon emission funding possibilities especially fuel taxes paper demonstrates offsetting carbon emissions produced roads area technically possible highly desirable unifying carbon sequestration biodiversity improvement rural development main challenge funding depends largely political awareness citizens elsevier rights reserved
postpartum sleep fatigue bidirectional relationships depressive symptoms challenge women everyday functioning everyday process managing postpartum sleep fatigue context depressive symptoms remains unexplored conducted grounded theory study sample women screened positive postpartum depression screening scale pdss short form weeks postpartum women completed semi structured home interviews full pdss modified fatigue symptoms checklist months postpartum sample average years old children african american described basic social process finding routine together women experiences infants progressed retreating month toward finding new normal month work find routine together mothers patterns change time continuous gradual prolonged progress influenced depressive symptoms social support work daycare stability social circumstances underlying stressors study findings suggest need allocate resources tailor interventions meet needs women vulnerable health effects ongoing persistent severe fatigue disordered sleep sub clinical clinical levels depressive symptoms wiley periodicals inc
hiv stigma continues major challenge addressing hiv aids various countries sub saharan africa including mozambique paper explores multidimensional nature hiv stigma thematic analysis five qualitative studies conducted high hiv prevalence provinces mozambique studies included interviews people living hiv plhiv women men focus groups peer educators women men working community based organisations cbos providing services plhiv focus groups community members men women interviews women men people family members living hiv aids focus groups men women interviews couples findings indicate hiv stigma barrier hiv testing counselling status disclosure partner notification antiretroviral therapy art access adherence moral stigma seems common physical stigma additionally findings highlight hiv stigma dynamic social process conceptualised tied personal responsibility effectively diminish hiv stigma mozambique future interventions address moral stigma conceptualise hiv chronic disease
paper explore different minimal solutions egomotion estimation camera based homography knowing gravity vector calibrated images solutions depend prior knowledge reference plane used homography demonstrate number matched points vary two three direct closed form solution grobner basis based solution derived according plane many experimental results synthetic real sequences indoor outdoor environments show efficiency robustness approach compared standard methods
introduction recently novel calreticulin calr mutations discovered janus kinase jak non mutated myelofibrosis pmf essential thrombocythemia cases frequency examined clinical correlations calr mutation frequency myeloproliferative neoplasms mpn cases introduce effective test method use clinical practice methods examined samples previously investigated jak mutation differential diagnosis mpn jak calr mutations analyzed using melting curve analysis microchip electrophoresis respectively next constructed test simultaneous screening jak calr mutations utilizing high resolution melting hrm results among mpn cases possessed jak mutation alone mpn cases without jak mutation positive calr mutation using novel screening test jak calr mutations hrm concordance rate conventional analysis hrm jak mutation calr mutation conclusion novel simultaneous screening test jak calr gene mutations hrm useful diagnosis mpn authors published elsevier
according evidence recent decades multicomponent programs psychological intervention people chronic pain reached highest levels efficacy however still many questions left answer since efficacy mainly shown among upper middle class patients english speaking countries controlled studies expert professionals guiding intervention limited number domains painful experience evaluated study program multicomponent psychological intervention implemented based techniques empirical evidence developed spain public primary care center among patients limited financial resources lower education novice psychologist evaluating domains painful experience using instruments recommended initiative methods measurement pain assessment clinical trials immpact aim study evaluate program selected consecutive sample patients treated chronic non cancer pain primary care center utrera seville spain adults employment dispute suffering psychopathology receiving psychological treatment patients participated psychological intervention sessions one per week groups people addressed psychoeducation pain breathing relaxation attention management cognitive restructuring problem solving emotional management social skills life values goal setting time organization behavioral activation physical exercise promotion postural sleep hygiene relapse prevention addition initial assessment measures taken intervention month follow assessed program throughout process implementation results analyzed statistically significance effect size clinical perspective clinical significance according immpact standards according analysis intervention successful although improvement tended decline follow detailed design gave program assessment high degree standardization specification finally suggestions improvement presented upcoming applications program
sustainability defined green building council usgbc achieved addressing three dimensions environment economic social research utilizes case study approach explore pre fabrication strategies impact sustainability goals construction projects addressing three aforementioned dimensions common tool lean practice prefabrication often used means improve productivity reduce material labor wastage prefabrication building components offsite controlled environment positive effect occupational safety reduced onsite hours heavy lifting therefore concluded prefabrication also addresses social dimension sustainability paper presents case study recently completed project prefabrication used construction building north facade traditional method used construction south facade thus providing ability compare analyze comparative impact prefabrication versus traditional construction goal sustainability paper discusses details process involved prefabrication starting decision making way execution procurement process use building information modeling bim perceived project performance sustainability results
laboratory testing tidal turbine models essential tool investigate hydrodynamic interactions turbines flow tests used calibrate numerical models estimate rotor loading wake development inform design full scale machines array layout details design manufacturing techniques used develop highly instrumented turbine model presented model diameter three bladed horizontal axis rotor bottom mounted particular attention given instrumentation measure streamwise root bending moment blade torque thrust overall rotor model mainly designed investigate blade shaft loads due turbulence waves initial results tests deep wide flume also presented authors published elsevier ltd
article undertakes retrospective appraisal nigeria widely acclaimed yet contentious success interventionist role liberia seeming inability contain threats posed members dreaded islamist militant jamaa ahlis sunna lidda awati wal jihad wilyat islmiyya gharb afrqiyyah also known boko haram drawing references scholarly articles electronic channels commissioned reports article explains nigeria appears losing war boko haram contrast modest strides liberia argue nigeria inability contain boko haram insurgency located within context home grown systemic challenges particularly ineffectual political leadership politicisation national security goodluck jonathan presidency
present vision system design landing unmanned aerial vehicle ship flight deck autonomously edge information international landing target used perform line segment detection feature point mapping clustering cascade filtering scheme applied target recognition meanwhile dof pose vehicle respect target estimated vision system implemented asctec pelican quadrotor conjunction state estimator perform real time target recognition tracking onboard controller designed close control loop experiments show vision system accurate robust capable dealing incomplete landing target whilst overall implementation shows practicability real time onboard target tracking closed loop control
lcl type filter widely used grid connected inverter however injected grid current control current harmonics low bandwidth caused resonance peak tolerated active damping method extra feedback provides high rejection resonance dynamic improved however high precision sensing circuit extra feedback increases cost paper signal flow graph response fitting methods method based feedback injected grid current proposed novel closed loop current control requires accurately sensing injected grid current observation needed compared extra feedback methods cost complexity reduced reliability improved based study relation controller system dynamic straightforward design proposed robustness harmonic rejection digital implementation studied compared conventional control methods proposed one promises satisfactory performance analog digital implementations simulations experiments verified proposed control design strategies
paper proposes effective method variation speed recirculation pump consequently ensure optimum range flow absorption chillers uses pair libr systems operate subatmospheric pressures merely reason use non invasive flow measurement methods need low power recirculation systems devices makes impossible adopt three phase loads driven pumps implications prevented achievement advances systems limiting success important contributions literature due designed experimental apparatus reproducing flow conditions submitted absorption chillers libr developed device could changing low power load speeds implemented labview language pid controller action system allowed tested flow control initially water saline libr
discussion violent video games tends engender extreme positions deserving deep skepticism ferguson issue claim humans something repeatedly effect examined carefully especially violates established psychological learning theories commentary examine three aspects ferguson claim first typical rhetorical trick sow doubt valuable examine doubting claims second good rhetoric direct attention one direction valuable examine direction within broader outlook third good rhetoric imply bias part one position valuable examine potential biases sides good science definitely requires skeptics problem violent video game debate perhaps skeptical enough
paper provides brief introduction ceos theory comprehensive theory understanding hard maintain behaviour change name ceos acronym context executive operational systems theory behaviour theorised result moment moment interaction internal needs operational processes relation environmental conditions humans augmented goal directed executive action transcend immediate contingencies behaviour generated operational processes goal directed behaviours triumph contingency generated competing behaviours operational processes sufficiently activated support affective force generated around executive system goals things memories direct experience vicarious experience emotionally charged communications mediated stories person generates paper makes refinements elaborations theory particularly around role feelings importance stories scripts facilitating executive action also sketches reconceptualises range issues relevant behaviour change ceos provides framework understanding limitations informational environmental approaches behaviour change need self regulatory strategies taking account basic aspects human functioning
systems ambient intelligence ami need manage workflows represent users activities workflows quite complex may involve multiple participants physical computational playing different roles execution implies monitoring development activities environment taking necessary actions workflow reach certain end context aware approach supports development applications cope event processing regarding information issues modeling actors context aware workflows complex decisions interactions must considered achieved multi agent systems agents autonomous entities sophisticated flexible behaviors able adapt complex evolving environments collaborate reach common goals work presents architectural patterns integrate agents top existing context aware architecture allows additional abstraction layer top context aware systems knowledge management performed agents approach improves flexibility ami systems facilitates design case study guiding users buildings meetings illustrates approach elsevier rights reserved
analog circuit designing important aspect vlsi chip design process designing analog circuits electronic design automation tools need equipped state art efficient circuit analysis optimization techniques paper novel approach optimize analog circuits gain bandwidth slew rate proposed using adjoint circuit analysis method method adjoint network original electrical electronic circuit constructed using linearized circuit original electrical network mos transistors replaced small signal model objective function need analyzed optimization analog circuit evaluated using linearized circuit adjoint network circuit along steepest descent method find next set design parameters optimize circuit design space barzilai borwein method used find direction design parameter vector circuit optimization process paper basic cascode amplifier circuit designed technology prove correctness proposed method prove effectiveness proposed approach two stage operational amplifier circuit also designed gain optimization subject variety design conditions constraints solution circuits designed optimized parameters calculated using proposed method matches solution cascode amplifier two stage operational amplifier circuits designed using mentor graphics tool pyxis eldo
helminth infections likely provide protective influence immune mediated metabolic diseases helminth infection dramatically decreased developed countries shortly explosive rise prevalence diseases capacity helminths activate immune regulatory circuits hosts modulate composition intestinal flora appears mechanisms protective action animal models disease show various helminth species prevent block inflammation various organs diverse range diseases clinical trials demonstrated medicinal exposure trichuris suis small numbers necator americanus safe minor reported adverse effects includes exposure inflamed intestine suis asthmathic lung americanus patients atopy efficacy suggested small studies absent others factors may led inconclusive results trials discussed date registered clinical trials using helminths treat metabolic syndrome component conditions however excellent safety profile suis americanus suggests studies possible
schizophrenia associated brain glutamate dysfunction currently unclear whether antipsychotic administration reduce extent glutamatergic abnormality conducted systematic review proton magnetic resonance spectroscopy mrs studies examining effects antipsychotic treatment brain glutamate levels schizophrenia medline database searched identify relevant articles published december inclusion required studies examined longitudinal changes brain glutamate metabolites patients schizophrenia initiation first antipsychotic treatment switch antipsychotic treatment searches identified eight eligible articles baseline follow measures total patients majority articles reported numerical reduction brain glutamate metabolites antipsychotic treatment estimated overall mean reduction glx combined signal glutamate glutamine across brain regions significant reductions glutamate metabolites least one brain region reported four eight studies none studies reported significant glutamatergic increase antipsychotic administration relationships degree change glutamate degree improvement symptoms inconsistent may provide limited evidence antipsychotic response may associated lower glutamate levels treatment greater extent glutamatergic reduction treatment longitudinal prospective studies glutamate antipsychotic response required confirm findings
interest laser therapy nonhormonal option treatment genitourinary syndrome menopause gsm increased conducted systematic review use laser therapy relief gsm symptoms six electronic databases searched conference abstracts searched manually introduction laser therapy present date keywords used genitourinary syndrome vulvovaginal atrophy postmenopausal symptoms laser therapy fractional laser treatment articles identified search none randomized controlled trial result included three observational studies without control group one case control study met inclusion criteria total number women included four studies collated data suggest laser therapy may valuable nonhormonal therapeutic modality management gsm higher quality evidence randomized controlled trials required establish efficacy laser treatment management gsm
parents children aged asd completed online surveys assessing parenting quality parenting stress child feeding challenges results indicated food selectivity frequently reported type challenging feeding behavior often reported problematic also type challenging feeding behavior associated parenting stress greater parenting stress reported parenting agreement support lower child disruptive behavior mealtime feeding challenge associated quality parenting paper points importance addressing feeding challenges addition selectivity disruptive mealtime behaviors within context family home environment
objectiveimpairment visual perception frequently occurs alzheimer disease cause severe constraints daily activities nonverbal raven colored progressive matrices rcpm test consists sets easily performed short time evaluate visual perception reasoning ability purpose study evaluate neural basis visual perception reasoning ability patients using rcpm single photon emission computed tomography spect methodsfifty patients fulfilled national institute aging alzheimer association criteria probable dementia examined rcpm spect spects performed using isopropyl iodoamphetamine multiple regression model used perform multivariate analyses relationships regional cerebral blood flow rcbf rcpm scores resultsthere significant positive correlation rcpm total score rcbf inferior parietal lobes bilaterally right inferior temporal gyrus right middle frontal gyrus set positively correlated rcbf right temporal right parietal lobes set positively correlated rcbf right temporal right parietal right frontal lobes set positively correlated rcbf right parietal right frontal lobes conclusionour findings suggest deteriorations specific brain regions associated dysfunction visual perception reasoning ability rcpm another informative assessment scale cognition use patients copyright john wiley sons ltd
performance improvement capability related organization ability utilize fundamental asset knowledge resides employees together learning past projects good links external knowledge sources firms develop mechanisms encourage conversation individuals teams take place particularly today post job security economic climate witness performance improvement individual team level thence overall performance organization paper reports performance improvement work taking place case study company post lean organization order develop capacity team organizational learning improve performance global marketplace
water pollution occur variety reasons change water colour presence harmful bacteria toxic waste spills paper presents application optical tomography system based artificial neural network ann predict turbidity level water sample system made use independent component analysis algorithm calculate value indicates attenuation value water turbidity level value utilized ann estimate turbidity level optical tomography system used evaluate water turbidity level pipeline without disturbing flow process evaluation mean square error mse sum square error sse regression analysis also enabled determine network performance demonstrated neural network effective inspecting water turbidity level best neurone structure revealed two hidden layers neurones first second layer respectively used training result shows formse sse regression testing part result neurone structure mse sse regression results revealed performance ann demonstrated good prediction capability turbidity level changed thus optical tomography system ann proved efficient tool classify water quality level beneficial water industry
although splenomegaly major characteristic primary myelofibrosis pmf splenomegaly devalued due less reliable method based physical examination pex evaluated whether spleen volume would accurately predict clinical outcomes pmf total patients enrolled quantitated automatic volume software roc curve predicted prognosis accurately spleen length pex ideal cut value divided high low volume status patients low status superior leukemia free survival overall survival compared high status cox analysis old age aeyen years low hemoglobin high wbc counts aeyen peripheral blasts aeyen unfavorable cytogenetic abnormalities high status independently associated survivals measured important predicting survival patients pmf
individuals study list words related another word presented lure word sometimes produce false memory studied lure word false memories observed lists words category category list associated associative list word presented attempt elicit false recall present study investigated whether young children create types false recall following study categorical list false recall elicited young children degree adults studying associative list elicited false recall adults furthermore categorically related lure words priming effect young children results suggest categorical false recall produced via different mechanism associative false recall
study comprehensively examined effects treatment interventions internet addiction among adolescents south korea meta analysis analyzed domestic master theses journal articles reported controlled studies involved pre post test analyses design dates publications fall total effect size calculated random effect analysis revealed interventions treatment internet addiction effective meta anovas revealed differences groups based theoretical model intervention group size intervention duration integrative therapy produced larger effect sizes compared treatment models cognitive behavioral therapy reality therapy effect sizes interventions including nine people larger interventions including fewer participants finally treatment interventions lasted weeks revealed larger effect sizes compared shorter interventions study findings suggest directions development effective operation future internet addiction interventions among korean adolescents increasing effectiveness interventions requires integrative theoretical model intervention group size nine participants long term intervention
unnecessary confusion still surrounds use combined hormonal contraceptives chcs setting migraine aura mwa clearing confusion key issue headache specialists since women migraine menstrual related migraine mrm chcs prevent particularly severe migraine use however still restricted current guidelines due concerns increased stroke risk concerns originated half century ago era high dose contraceptives yet studies consistently show stroke risk increased today low dose chcs containing ethinyl estradiol continuous ultra low dose formulations may even reduce aura frequency thereby potentially decreasing stroke risk article clarifies stroke risk chcs examines impact migraine also examines stroke risk altered estrogen content chc contributing factors smoking age hypertension aura frequency finally puts risks meaningful context risk benefit assessment
background almost pregnancies united states unwanted mistimed notably one half unintended pregnancies occurred birth control used suggesting inappropriate poor use contraceptive failure two thirds women reproductive age use contraceptives oral hormonal contraceptives remain common contraceptive method often contraceptive products obtained community pharmacies purpose study determine whether pharmacy based intervention would impact sales contraceptive products pharmacies methods study conducted iowa used quasi experimental design including community pharmacies independent grocery counties intervention grocery pharmacies counties comparison group passive intervention focused towards year old women visited community pharmacies prompted childbearing age plan pregnancy consider using birth control intervention delivered via educational tri fold brochures posters shelf talkers data sources evaluation contraceptive sales intervention comparison pharmacies mixed negative binomial regression used study group time interactions examine impact intervention oral contraceptive condom sales data considered baseline sales results condom sales decreased time oral contraceptives sales showed change overall units sold significantly higher grocery pharmacies independent pharmacies contraceptive types negative binomial regression condoms overall significant interaction study group time variables indicating effect intervention significant slowing drop sales time comparison time statistically significant association pharmacy type study group independent intervention pharmacies higher proportion stores increases condom sales compared grocery pharmacies intervention comparison group conclusions passive community pharmacy based public health intervention appeared reduce decrease condom sales baseline particularly independent pharmacies impact oral contraceptive sales
sparse matrix vector multiplication spmvm time consuming kernel many numerical algorithms studied extensively modern processor accelerator architectures however optimal sparse matrix data storage format highly hardware specific could become obstacle using heterogeneous systems also yet unclear wide single instruction multiple data simd units current multi many core processors used efficiently structure sparsity pattern matrix suggest sellc sigma variant sliced ellpack simd friendly data format combines long standing ideas general purpose graphics processing units vector computer programming discuss advantages sell sigma compared established formats like compressed row storage ellpack show suitability variety hardware platforms intel sandy bridge intel xeon phi nvidia tesla wide range test matrices different application areas using appropriate performance models develop deep insight data transfer properties sell sigma spmvm kernel sell sigma comes two tuning parameters whose performance impact across range test matrices studied reasonable choices proposed leads hardware independent catch sparse matrix format achieves high efficiency test matrices across hardware platforms
shape correspondence fundamental problem computer graphics vision applications various problems including animation texture mapping robotic vision medical imaging archaeology many settings shapes allowed undergo non rigid deformations partial views available problem becomes challenging end present non rigid multi part shape matching algorithm assume given reference shape multiple parts undergoing non rigid deformation query parts additionally contaminated clutter may overlap parts might missing parts redundant ones method simultaneously solves segmentation reference model dense correspondence subsets parts experimental results synthetic well real scans demonstrate effectiveness method dealing challenging matching scenario
background although many web based mental health interventions released actual uptake end users limited marginal level engagement end users developing interventions recognized important cause uptake problems paper offer perceptive improve user engagement aim stimulate discourse user involvement within field online mental health interventions methods shortly describe three different methods expert driven method intervention mapping scrum currently used develop web based health interventions focus extent end user involved developmental phase additional challenges final paragraph lessons learned summarized recommendations provided results every method seems trade end users highly involved availability end users means become problematic end users less actively involved product may less appropriate end user challenges consider funding active role technological companies time takes process results shorter development cycles conclusion thinking user centered design carefully planning involvement end users become standard field web based mental health deciding level user involvement one balance need input users availability resources time funding
work sensor build smart material based polymer brush gold nanoparticles modified electrode functionalized polymer brush polyacrylic acid paa tethered surface covered gold nanoparticle ito paa demonstrated switchable interfacial properties discriminating different phs switchable electrochemical plasmonic process characterized differential pulse voltammetry dpv faradaic impedance spectroscopy eis cyclic voltammetry localized surface plasmon resonance lspr
across cultures humans engage cooperative activities simple preparing meal sharing food others complex playing orchestra donating charity although intraspecific cooperation exists among many animal species humans engage wide array cooperative interaction participate large scale cooperation extends beyond kin even includes strangers
timely identification treatment osteoporosis following hip fracture recommended mitigate future fracture risk yet prior work demonstrated disconnect evidence based recommendations real world implementation sought describe contemporary patterns osteoporosis screening initiation pharmacotherapy following hip fracture based medical pharmacy claims optumlabs data warehouse national sample identified women aged years enrolled private commercial medicare advantage plans prior history osteoporosis diagnosis osteoporosis pharmacotherapy hip fracture experienced hip fracture women evidence osteoporosis assessment treatment within months fractures respectively women aged years one third less likely utilize recommended services within months compared aged years versus utilization bone mass measurement increased significantly among women aged years study period declining among aged years contrast rates osteoporosis pharmacotherapy remained steady among women aged years yet declined among women aged years aged years respectively accounting differences measured characteristics receipt primary care strongest consistent predictor osteoporosis assessment treatment following fracture american society bone mineral research
parabolic synthesis methodology approximation methodology implementing unary functions trigonometric functions logarithms square root well binary functions division hardware unary functions extensively used baseband wireless wireline communication computer graphics digital signal processing robotics astrophysics fluid physics games many areas high speed applications well low power systems software solutions sufficient hardware implementation therefore needed parabolic synthesis methodology way implement functions hardware based low complexity operations simple implement hardware difference parabolic synthesis methodology compared many approximation methodologies multiplicative contrast additive methodology improve performance parabolic synthesis based designs methodology combined second degree interpolation paper shows methodology provides significant reduction chip area computation delay power consumption preserved characteristics error evaluate logarithmic function implemented example using parabolic synthesis methodology comparison parabolic synthesis methodology combined second degree interpolation demonstrate feasibility methodologies compared cordic methodology comparison made implementation fractional part logarithmic function bit resolution designs implemented using parabolic synthesis methodology without second degree interpolation perform better respectively cordic implementation terms throughput terms energy consumption cordic implementation consumes energy respectively chip area also smaller case parabolic synthesis methodology combined second degree interpolation used elsevier rights reserved
security primary requirement era informationization threats worms rising high degree penetrating system need security system analyze provide valuable information organization honeypot provides technology adds layer network security goal honeypot distract attacker real systems gain valuable information comparison intrusion detection technologies honeypot far better ability detect new attacks improve security network using existing intelligence security technologies honeypot designed get compromised new threats welcome attackers attack analyze behavior honeypot attractive alternative acts trap detect suspicious breaches network security
background coronal malalignment lower extremity closely related onset progression osteoarthritis restoring satisfactory alignment tibial osteotomy improves long term success conservative surgery purpose study determine difference two dimensional measurements hip knee ankle hka angle mechanical axes femur tibia parameter affects hka measurement percentage patients risk error hka measurement methods reviewed imaging studies consecutive patients referred hip knee pain june october patients previous pelvis lower extremity surgery excluded results lower extremities examined method showed valgus method method showed varus extremities knee varus valgus alignment completely opposite images compared images degrees flexum recurvatum alignment increased error hka measurement degrees calculated degrees per degrees increase femoral torsion degrees per degrees increase tibial torsion approximately patients might risk error hka angle measurement imaging studies conclusions orthopaedic surgeons assess lower extremity alignment standing position enough exposure extremity find severe alignment rotational deformities consider advanced images patients otherwise hka angle measured good accuracy techniques
multi server authentication enables subscribers enjoy assortment services various service providers based single registration registration centre previously subscriber register service provider individually avail respective services relying single server authentication past number multi server authentication techniques witnessed employed lightweight even computationally intensive cryptographic operations line zhu presented chaotic map based multi server authentication scheme recently vulnerable denial service attack stolen verifier attack also lacks anonymity research aims improving zhu protocol terms cost efficiency moreover comparative study presented performance improved model existing scheme security proposed model formally proved using ban logic
bovine leukemia virus blv causative agent enzootic bovine leukosis malignant cell lymphoma spread worldwide causes serious problems cattle industry blv proviral load represents blv genome integrated host genome useful index estimating disease progression transmission risk conducted genome wide association study identify single nucleotide polymorphisms snps associated blv proviral load japanese black cattle study examined cattle high proviral load low proviral load three snps showed significant association proviral load one snp detected cntn gene chromosome two linkage disequilibrium detected bovine major histocompatibility complex region chromosome results suggest polymorphisms major histocompatibility complex region affect proviral load first report detect snps associated blv proviral load japanese black cattle using whole genome association study understanding host factors may provide important clues controlling spread blv japanese black cattle
bubble pump proposed replace traditional mechanical solution pump lithium bromide absorption chillers advantageous feature driven industrial waste heat solar energy low grade energy two stage bubble pump driven lithium bromide absorption refrigeration system flow patterns lifting pipe significant effects performance bubble pump paper single bubble motion double bubbles coalescence vertical ascending pipe simulated improved free energy model lattice boltzmann method two phase liquid gas density ratio details bubbles coalescence process studied density velocity bubbles obtained computational results show initial radius bubble great influence coalescence time larger initial bubble radius shorter coalescence time pipe diameter little effect two bubbles coalescence time significant effect bubble velocity pipe diameter increases bubble velocity increases obtained results helpful studying transition mechanisms two phase flow patterns useful improving bubble pump performance controlling flow patterns lifting pipe elsevier ltd rights reserved
development fibre reinforced polymer frp piping high corrosion resistance specific properties attractive engineering proposition high potential advantageous properties make frp piping potential candidate replacing metallic piping structure oil gas industry despite advantages associated frp application limited due part unsatisfactory methods joining composite subcomponents inadequate knowledge failure mechanism different loading conditions aim present paper study effect pipe scaling strength adhesively bonded frp pipes using finite element analysis study performed investigate dimensional effects adhesive joint strength based strength materials fracture mechanics considerations results indicate shift failure adhesive composite material increasing pipe diameter tsai von mises failure criteria employed strength analysis composite pipe sections adhesive material respectively fracture mechanics approach used assess changes cohesive failure within adhesive interfacial failure adhesive frp interface increasing pipe diameters published elsevier ltd selection peer review responsibility icm
paper presents fuzzy pid fpid control scheme blood glucose control type diabetic subjects new metaheuristic cuckoo search algorithm csa utilized optimize gains fpid controller csa provides fast convergence capable handling global optimization continuous nonlinear systems proposed controller amalgamation fuzzy logic optimization may provide efficient solution complex problems like blood glucose control task maintain normal glucose levels shortest possible time minimum insulin dose glucose control achieved tuning pid proportional integral derivative fpid controller help genetic algorithm csa comparative analysis designed controllers tested bergman minimal model control blood glucose level facets parameter uncertainties meal disturbances sensor noise results reveal performance csa fpid controller superior compared designed controllers
article reports findings focus group conversations depth interviews things parents take care children health toronto canada data demonstrate within single urban setting parents differently positioned effectively find engage existing healthcare resources parents family health work shaped systemic expectations health institutional literacy inter institutional navigation skills parents possess equal measure intensive focus ontario paediatric healthcare settings patient parent education suggests increased interest cultivating autonomous health information seeking use strategies among parents degree parents health information seeking use strategies deemed effective depends whether able construct coherence know child health take care knowledge medical system requires support diagnosis treatment research suggests healthcare system interested information seeking autonomy insofar supports patients engagement systems existing practices frames validity service pathways people unable demonstrate health knowledge work support existing systemic processes effectively use know support children health wellness
genetic factor previously shown play important role sports injuries recovery gdf single nucleotide polymorphism recently reported associated fracture susceptibility furthermore effect gdf recovery processes trauma increased present study aimed evaluate whether snp associated susceptibility meniscus injury postoperative recovery chinese male soldiers gdf snp genotyped male soldiers meniscus injury healthy male controls moreover function recovery soldiers suffering meniscal repair also assessed data showed gdf genotype allele significantly represented meniscus injury group compared control group found carriers genotype exhibited significantly higher lysholm scores genotype month postoperative addition genotype also demonstrated significantly higher lysholm scores genotype months postoperative taken together results revealed gdf snp associated susceptibility meniscus injury postoperative function recovery chinese male soldiers
background poor asthma control observed several surveys may related lack systematic assessment physicians patient underestimation symptoms along line purpose study investigate level asthma control patients attending office different reasons either renewal drug prescription worsening asthma symptoms methods general practitioners italy spain selected least eight asthmatic patients attending office renewal drug prescription group worsening asthma symptoms group may december asthma control test act clinical information including questionnaire collected results data patients moderate severe asthma analysed mean age years female smokers smokers treatment ics laba combination act score uncontrolled asthma observed group patients expected also group patients uncontrolled patients reported asthma well fairly well controlled cases risk factors uncontrolled asthma older age asthma severity smoking habit uncontrolled patients gps changed increased level therapy initiated asthma treatment cases association educational intervention closer monitoring pulmonologist consultations discussion systematic use act asthmatics attending clinic may detect high rates uncontrolled patients underestimate clinical conditions particularly asking solely asthma medication renewal poor adherence daily drug therapy reported patients could important contributor uncontrolled asthma conclusions results highlight importance routine longitudinal assessment asthma patients primary care point need increased attention asthma management gps
introduction implantable cardioverter defibrillator icd electronic device emits electrical signals heart via lead wires electrodes used cardiac rhythm monitoring treatment electronic dental devices shown produce electromagnetic fields hypothesize may interfere icd function methods nine dental devices heat carrier electronic apex locator electric pulp tester unipolar electrosurgery unit electric motor curing light gutta percha guns tested study ability interfere function icds single chambered dual chambered icds icd activity monitored seconds using icd programmer medtronic minneapolis evaluated electrogram test strip printout results electromagnetic interference detected electric motor curing light electric pulp tester electrosurgery unit although electromagnetic disturbances detected devices electrornagnetic interferences observed gutta percha guns heat carrier apex locator however electrosurgery unit affected dual chambered icd consulta crt medtronic delivered therapies fibrillation ventricular fibrillation present conclusions results suggest electrosurgery unit produces electromagnetic disturbances unwanted therapy delivery shock potentially clinically significant outcomes
letter reports lead ion sensor composed tapered multimode fibre mmf coated chitosan diameter length tapered fibre region respectively tapered mmf used flexible compact compared plastic clad silica chitosan chosen sensing layer absorb heavy metal ions due unique properties polyelectrolyte chelating agent refractive index chitosan layer changes absorbs lead ion leads increase absorbance measured spectrophotometer tested immersing sensor solution contains lead ion different concentrations ppm results show absorbance measured spectrophotometer increased concentration lead ion increased sensor average sensitivity measured abs ppm sensor simpler compared surface plasmon resonance based lead ion sensor require metal coating prior sensing layer coating
hypothesized hypoxia induced testicular damage mediated activated nadph oxidase nox therefore apo apocynin inhibitor nox raisanberine calcium influx inhibitor tested could attenuate hypoxic toxicity testis male sprague dawley rats exposed hypoxia intervened apo last histological changes expression pro inflammation factors evaluated vivo biomarkers isolated leydig cells incubated also assayed vitro hypoxic rats displayed lower serum testosterone higher fsh upregulation phox nox mmp perk pshc associated downregulation star beta hsd hypoxia testis revealed western blot immunohistochemical assay respectively apo least partially normalize hypoxia caused male hypogonadism suppressing stress pshc testes elsevier inc rights reserved
licon methodology approach predicting lifetime materials creep loading conditions licon method predicts long time uniaxial creep strength using results several short duration creep crack incubation cci tests conjunction outcome mechanical analysis testpiece method first applied creep ductile notch insensitive materials reference stress solution appropriate advanced pipe steels original concept mechanical analysis part methodology therefore adopt reference stress solutions study explains challenges involved application reference stress based licon method creep brittle notch sensitive materials identifies need careful implementation advanced mechanical analyses finite element analysis fea application details presented consideration fea licon methodology demonstration successful application fea based licon method creep life assessment non reference stress material high creep strength hcs crmov steel elsevier ltd rights reserved
background aims esophageal dysmotility associated gastrointestinal dysmotility various systemic neuroregulatory disorders hypothyroidism reported associated impaired motor function esophagus due accumulation glycosaminoglycan hyaluronic acid soft tissues leading changes various contraction relaxation parameters esophagus particularly lower esophageal sphincter study evaluated esophageal transit times patients primary hypothyroidism using technique radionuclide esophageal transit scintigraphy methods thirty one patients primary hypothyroidism euthyroid healthy controls evaluated esophageal transit time using mbq technetium sulfur colloid diluted drinking water time activity curve generated study esophageal transit time calculated time taken clearance radioactive bolus region interest encompassing esophagus esophageal transit time seconds considered prolonged results patients primary hypothyroidism significantly increased mean esophageal transit time seconds comparison mean time seconds healthy controls esophageal transit time improved patients even normalized treatment thyroxine positive correlation albeit weak existed serum thyroid stimulating hormone observed esophageal transit time conclusions significant number patients primary hypothyroidism may subclinical esophageal dysmotility prolonged esophageal transit time reversible thyroxine treatment prolonged esophageal transit time primary hypothyroidism may correlate serum thyroid stimulating hormone levels
much person perception literature focused solely representation superordinate social categories race age superordinate social categories may organized smaller subcategories subtypes subgroups distinguished perceived typicality based logic atypical subcategories represent subtypes typical subcategories represent subgroups hypothesized subcategory labels would elicit greater perceived stereotypicality compared others experiment participants listed stereotypic traits rated perceived typicality subcategories black white men experiment used reverse correlation image classification procedure estimate participants visual representations faces black white superordinate category subcategory members results indicated representations black subgroups reflected traits features prototypical black men compared representations black subtypes similarly representations white subgroups reflected traits features prototypical white men compared representations white subtypes current experiments clarify nature subcategory representations subgroups subtypes within superordinate category implications stereotype maintenance change considered elsevier inc rights reserved
paper study control power frequency turbo generator couple power grid developed linear mathematical models steam turbine electrical generator used power control system design dynamic control system simulated using matlab simulink
backgroundpatients myeloproliferative neoplasms mpns experience high persistence prevalence severity fatigue currently limited information regarding factors contribute fatigue patients mpns methodsa item internet based survey regarding fatigue developed mpn investigators patients advocates hosted mayo clinic survey research center resultsfatigue found prevalent severe among international survey respondents respondents higher body mass index current use alcohol current tobacco use found significantly associated greater fatigue moderate severe fatigue present frequently individuals exercise compared reported exercising least per week medical comorbidities found significantly associated greater fatigue included restless leg syndrome diabetes mellitus fibromyalgia chronic fatigue syndrome chronic kidney disease current use antidepressants antihistamines antianxiety medications prescription pain medications patient health questionnaire indicating high probability depression higher brief fatigue inventory score myeloproliferative neoplasm total symptom score individual symptom items associated higher likelihood depressive symptoms conclusionsthe management fatigue multifactorial comprehensive assessment treatment plan address modifiable fatigue etiologies patients mpns likely higher prevalence mood disturbances compared general population suggesting need assess intervene domain cancer american cancer society
aim study analyze registering preventative actions relation child morbidity using information regarding vaccinations well iron vitamin supplements recorded children health cards transversal study used quantitative approach performed family health units city joao pessoa paraiba sampling convenience totaled children health cards data collected observing cards analysis simple statistical highest percentage children vaccination cards date aged months cards records relating iron vitamin supplements others records one supplements administered vaccination status children first year life found satisfactory however discrepancies observed recordings administration iron vitamin supplements complicates monitoring performed child health care professionals hoped study contribute discussions strategies aimed improving monitoring recording micronutrients children health cards
objectivea large body factor analytic research supports idea common mental disorders organized along correlated latent dimensions termed internalizing externalizing eating disorders eds associated internalizing mood anxiety disorders externalizing substance use antisocial personality disorder forms psychopathology previous studies found eds strongly related internalizing disorders however previous factor analytic studies eds internalizing externalizing dimensions evaluated eds align spectra similarly men women examined location anorexia nervosa bulimia nervosa binge eating disorder bed symptoms within model psychopathology among sample veterans population traditionally understudied eds methoddata two studies veterans intimate partners men women participants administered structured clinical interview dsm without skip outs lifetime symptom severity scores used confirmatory factor analytic models resultsa model bed symptoms loading onto distress subfactor internalizing domain fit data best full sample male female subsamples model statistically equivalent men women discussionall three eds loaded onto distress indicating conditions overlap psychopathology characterized negative affect investigating latent dimensions psychopathology one approach identifying common factors partially account patterns comorbidity among psychiatric disorders may aid translating research findings clinical practice wiley periodicals inc int eat disord
previous research demonstrated psychopathic personality traits significantly predictive blunted cortisol reactivity performance based stressor task trier social stress test tsst college students however relationship cortisol reactivity psychopathy explored high risk samples incarcerated populations role imprisonment relation cortisol stress reactivity previously explored could practical conceptual consequences regard rehabilitation biological sensitivity context respectively current study tested hypotheses psychopathic personality traits amount time incarcerated related cortisol blunting response stress among incarcerated young adults sample young adult male offenders recruited complete tsst salivary hormone samples taken prior min post stressor participants interviewed psychopathy checklist youth version variables quantifying amount time present facility prior date testing number commitments juvenile facilities also collected correlational analyses indicated number incarcerations related blunted cortisol hierarchical linear modeling revealed time incarcerated number commitments related blunted cortisol response among responders declining cortisol reactivity among nonresponders respectively controlling time incarcerated psychopathic traits significantly related cortisol decline response stressor among nonresponders related blunted cortisol among responders results project highlight potential biological effects prolonged repeated incarcerations extend understanding relationship psychopathic traits cortisol reactivity incarcerated sample elsevier inc rights reserved
purpose purpose paper develop content analysis framework derive process model knowledge construction context virtual product user communities organization sponsored online forums product users collaboratively construct knowledge solve technical problems design methodology approach study based deductive qualitative content analysis discussion threads solving technical problems selected series virtual product user communities data complemented thematic analysis interviews forum members findings research develops content analysis framework knowledge construction based combination existing codes derived frameworks developed computer supported collaborative learning new categories identified data analysis using framework allows authors propose knowledge construction process model showing elements organized around typical trial error knowledge construction strategy practical implications research makes suggestions organizations management knowledge activities virtual product user communities including moderators roles facilitation originality value paper outlines new framework analysing knowledge activities low level critical thinking model knowledge construction trial error new framework model applied similar contexts
various methods exist today increasing effectiveness internal combustion engines ice mainly focused improving thermodynamic processes engine fuel efficiency technological improvements however little effort put finding new schemes main mechanism ice could improve kinematic dynamic characteristics aim research optimize dynamics new kinematic scheme slider crank mechanism ice allows achieve increased engine effectiveness achieving maximum torque maximum pressure gases minimal volume combustion chamber also achieve reduction mechanical loads engine components thereby reducing dimensions mass engine optimal parameters new row two shaft ice permits achievement set goal found achieved dynamic characteristics compared classical ice study carried using vector modular models authors published elsevier ltd
acceleration grid power supply agps important part neutral beam injector nbi system increase nbi power requirement output voltage agps becoming higher higher even reaching inverter type high voltage power supply uses inverters located lower voltage side regulate cut output voltage suitable high voltage applications proposed scheme agps international thermonuclear experimental reactor iter nbi system comprises five stages stage inverter type power supply output voltage paper investigates inverter type power supply based neutral point clamped three phase three level tptl inverter three phase step transformer equivalent insulated tptl converter connected dual link order design preferable controller inverter type power supply topology principles tptl converter duty cycle modulation analyzed indicates converter operates large duty cycle output voltage ripple limited hence small signal model converter duty cycle larger established following mathematical model single loop pid controller designed prototype built simulation experimental results verify correctness theoretical analysis system achieves lower output voltage ripple fast dynamic response
rapid eye movement rem sleep behavior disorder rbd sleep disorder characterized enacting one dreams rem sleep dreams violent aggressive patients often come see doctor complaining hurting bed partners sleep prevalence rbd based population much higher patients neurodegenerative diseases especially synucleinopathies rbd may herald emergence synucleinopathies decades may used effective early marker neurodegenerative diseases pharmaceutical treatment rbd includes clonazepam melatonin pramipexole newly reported medications review summarized clinical psg features rbd pathophysiology therapy focusing correlation neurodegenerative diseases rbd order emphasize significance rbd early marker neurodegenerative diseases
ammonia key commodity chemical vital importance fertilisers made industrial scale via haber bosch process requires significant infrastructure place ammonia generally made large centralized facilities ammonia could produced less demanding conditions would potential smaller devices used generate ammonia decentralized manner local consumption electrochemistry proposed enabling technology purpose relatively simple scale electrolytic devices meet almost level demand moreover possible envisage electrosynthetic cells water could oxidised produce protons electrons anode could used reduce protonate nitrogen give ammonia cathode nitrogen sourced air required infrastructure process would supplies water air electricity latter could provided renewables hence electrosynthetic cell ammonia production could allow generated sustainably small low cost devices requiring minimal facilities review describe recent progress towards electrosynthetic ammonia production devices summarizing also seminal literature field comparison made various different approaches taken key remaining challenges electrosynthesis ammonia highlighted elsevier rights reserved
people often perceive attractive likable others examined self favoring biases manifest highly popular novel context particularly self focusedselfies specifically analyzed selfie takers non selfie takers perceptions selfies versus photos taken others compared judgments external perceivers although selfie takers non selfie takers reported equal levels narcissism found selfie takers perceived attractive likable selfies others photos non selfie takers viewed photos similarly furthermore external judges rated targets less attractive less likable narcissistic selfies photos taken others thus self enhancing misperceptions may support selfie takers positive evaluations selfies revealing notable biases self perception
given two linear projections maximal rank grassmann tensor introduced hartley schaffalitzky int comput vis doi turns generalized fundamental matrix matrices studied detail particular rank computed dimension variety parameterizes matrices also determined algorithmic application generalized fundamental matrix projective reconstruction described
drug delivery systems dds based concept providing optimal amount drug specific area requiring treatment liposomes lipid based nanoparticles capable encapsulating drug membrane aqueous phases potential targeted surfaces modified functional molecules antibodies peptides thus liposomes strong potential drug carriers designed active targeting research group recently developed new concept liposome targeting called reverse targeting dds dds dds differs conventional active targeting surface liposomes modified antigenic molecule specifically recognized antigen specific immune cells review describes detail differences two dds targeting concepts proposes application dds treatment allergies based research using ovalbumin model allergy antigen
show significant quasi periodic cycles present century long rain rate experimental statistics milan italy number rainy days year average duration daily rainy time average duration rain events min rain rate complementary probability distributions pds short obtained integrating historical time series daily rainfall pds recently published integration theory fft analysis shows significant power periods years cyclic nature rain rate clearly evident time series min rain rate exceeded annually probability fraction time impact communication design direct rain attenuation pds follow trend future work concern localities potential use results predicting min rain rate pds
response hiv many countries adopted enacted policies reduce transmission increase hiv related service use theoretically policy level interventions hiv prevention potential improve health behavior outcomes policy interventions vary scale relatively minor changes clinical policy major national legal initiatives assessing effectiveness hiv policy interventions challenging undertaking many policies exist guide hiv programmes relatively specifically evaluated effects reducing hiv risk taking increasing hiv health seeking behaviors thus questions effectiveness policy interventions prevent hiv change hiv related risk behaviors remain largely unanswered address current gap literature systematically reviewed existing evidence effect hiv policy interventions changing hiv related behaviors low middle income countries
vegetables waste generally utilized bioconversion process disposed municipal landfills dumping sites dumped open land emitting foul odor causing health hazards presents study deals alternative way utilize solid vegetable waste thermochemical route briquetting gasification energy recovery subsequent power generation briquettes diameter produced four different types vegetable waste bulk density briquettes produced increased times higher density dried vegetable waste loose form lower heating value lhv briquettes ranged depending type vegetable waste gasification briquettes carried open core downdraft gasifier resulted syngas calorific value gasification temperature degrees degrees spark ignition internal combustion engine run syngas could generate maximum load cold gas efficiency hot gas efficiency gasifier measured respectively energy recovery organic vegetable waste possible thermochemical conversion route briquetting subsequent gasification recovery fuel small scale power generation
arid conditions northern chile restrict access water energy work describes experimental behavior solar water heating system combined floating covers photovoltaic cells two similar ponds used holding water one heated unheated heated pond featured coil containing enclosed circulating fluid heated solar heat collectors minimize water evaporation exposed surfaces two ponds covered floating elements photovoltaic cells top supply energy water pumping power auxiliary devices system predicted daily average water temperature values determined heat mass transfer model using experimental meteorological data eight months continuous operation good agreement measured data pond floating covers water evaporation reduction greater respect uncovered pond also photovoltaic cells placed floating cover generated equivalent electric power global average daily water solar heating measured pond equivalent kwh elsevier ltd rights reserved
regional labour force participation across european union time space recursive modelling approach endogenous regressors spatial economic analysis although abundant regional labour market literature taking spatial perspective studies explored extending analysis labour force participation spatial effects paper revisits important issue proposing time space recursive modelling approach builds appraises fogli veldkamp methodology finding united states participation rates vary past values nearby regions major shortcomings study corrected including stationarity control endogenous regressors time space time lagged dependent variable using system generalized method moments gmm paper also highlights interaction effects among explanatory variables first time context using panel regions across european union results total male female participation rates throw new light socio economic relevance different determinants importantly characteristics neighbouring regions play significant role neglecting endogeneity found serious consequences underlining increased attention specification estimation spatial econometric models endogenous regressors
cross sectional ovalization thin walled circular steel tube large plastic bending also known brazier effect usually occurs initial stage tube continuous rotary straightening process maximal cross section flattening ovalization important technical parameter tube straightening process control tube bending deformation prevent buckling however lack special analytical model determined accordance specified charts developed experienced operators basis experimental data thus inevitable local buckling occur actual straightening operation present paper simplified normal strain component formulas derived based thin shell theory strain energy thin walled tube per unit length obtained subsequently using elastic plastic theory finally rational model predicting maximal section flattening thin walled circular steel tube straightening process presented principle minimum potential energy simplified model validated experiments numerical simulations results show model agrees well experiments numerical simulations less error new model expected find potential application thin walled steel tube straightening machine design elsevier rights reserved
unmethylated cytosine guanine dinucleotide containing oligodeoxynucleotides cpg odns synthetic agonists toll like receptor tlr activate humoral cellular immunity developed vaccine adjuvants prevent treat cancers infectious diseases allergies free cpg odns used many clinical trials implemented verify effects however recent research reported self assembled cpg odns protein peptide cpg odn conjugates nanomaterial cpg odn complexes demonstrate higher adjuvant effects free cpg odns owing improved uptake efficiency cells expressing tlr moreover protein peptide cpg odn conjugates nanomaterial cpg odn complexes able deliver cpg odns antigens allergens types cells enables higher degree prophylaxis therapeutic effect review author describes recent trends research development cpg odn nanomedicines containing self assembled cpg odns protein peptide cpg odn conjugates nanomaterial cpg odn complexes focusing mainly results preclinical clinical studies
although motion estimation approaches fluid flows widely studied computer vision domain existing algorithms accurately deal regions slight drastic brightness changes address issue paper introduces novel data structure called brightness distribution matrix bdm used accurately model regional brightness based proposed consistency constraints energy function obtain motion vectors image sequences high accuracy since bdm based approach requires large number computations dealing complex fluid scenarios reduce overall time parallelized version approach developed based graphics processing unit gpu experimental results show gpu based approach used improve quality complex fluid images also reduce overall processing time times improvement
soybean research work india intended towards yield improvement biotic abictic stress management food grade characteristics resulted varieties notified maximum yield potential increase resistant tolerant insects pests moisture stress well higher nutritional characteristics yield index yield soybean increased since itshitroduction commercial cultivation technology achievement index increased per hectare value crops output constant prices increased per cent districts higher proportion gross cropped area soybean also per hectare value output higher major soybean growing districts districts exceptions though present varieties exist seed chain however four varieties dominate seed chain account per cent total soybean seed requirement country per cent seed availability bridge continual increase demand edible oil nutritional requirements genetic improvement soybean attenuating major issues required
simultaneous wireless information power transfer swipt recently drawn significant attention however due broadcast nature wireless channels guaranteeing security swipt system important research area paper propose analyze low feedback overhead low signal processing cost scheme using transmit antenna selection tas enhance physical layer security miso swipt system formulate power splitting ratio algorithm design optimization problem maximizes secrecy rate valid receiver transmit power energy harvesting constraints solving problem secrecy rate energy function derived results show increasing transmit number larger region achieved
background buckwheat common cause life threatening allergy asia examined oral food challenges ofcs using describe ofc outcomes diagnosis confirmation tolerance acquisition clarify risk factors positive ofcs methods july march retrospectively reviewed data children underwent ofcs using protein sagamihara national hospital children suspected allergy positive results specific ige previously diagnosed allergy owing immediate reactions results patients analyzed aged years median age years forty four reacted ofc experienced anaphylaxis among patients suspected allergies reacted ofc however among patients definitive allergies underwent ofcs median years last immediate reaction reacted ofc among patients past anaphylactic reactions exhibited tolerance history immediate reaction high specific ige levels significant risk factors positive ofc conclusions allergies rare among children suspected allergies due positivity specific ige children definitive allergies tolerate even anaphylactic reactions nevertheless careful observation needed performing ofcs considering high incidence anaphylactic reactions author published karger basel
propose heralded quantum repeater based scattering photons single emitters one dimensional waveguides show details implementing nonlocal entanglement generation entanglement swapping entanglement purification modules atoms waveguides discuss feasibility repeater currently achievable technology scheme faulty events discarded detecting polarization photons protocols accomplished fidelity principle advantageous implementing realistic long distance quantum communication moreover additional atomic qubits required single photon medium scheme scalable attractive since realized solid state quantum systems great progress controlling atom waveguide systems repeater may useful quantum information processing future elsevier inc rights reserved
dyskeratosis congenita rare inherited disorder ectodermal dysplasia consists classical mucocutaneous triad abnormal skin pigmentation nail dystrophy leukoplakia pulmonary disease seen characterized idiopathic pulmonary fibrosis ipf idiopathic familial pulmonary fibrosis ifpf non specific interstitial pneumonia nsip reported rarely children isolated adult patient patient classical clinical presentation pancytopenia portal hypertension clinic radiological features nsip rare association
parallel time integration method nonlinear partial differential equations proposed based new implementation paraexp method linear partial differential equations pdes employing block krylov subspace method nonlinear pdes algorithm based paraexp implementation within waveform relaxation initial value problem solved iteratively complete time interval nonlinear terms treated source terms provided solution previous iteration iteration problem decoupled independent subproblems principle superposition decoupled subproblems solved fast exponential integration based block krylov method new time integration demonstrated one dimensional advection diffusion equation viscous burgers equation numerical experiments confirm excellent parallel scaling linear advection diffusion problem good scaling case nonlinear burgers equation simulated elsevier rights reserved
background older adults thyroid stimulating hormone tsh concentrations raised higher free thyroxine associated poorer health outcomes use nonage appropriate reference ranges could lead suboptimal management aimed define reference intervals tsh older men methods conducted study community dwelling men aged years baseline tsh levels assayed elecsys roche diagnostics conventional reference intervals tsh miu pmol respectively incident deaths ascertained using data linkage results men included analysis centiles tsh miu pmol respectively healthy men defined excellent good self rated health absence major medical comorbidities centiles tsh miu pmol respectively tsh associated mortality whereas higher associated increased mortality applying intervals based healthy older men cohort whole led reclassification men men classified hyperthyroid hypothyroid subclinical hyperthyroidism fewer subclinical hypothyroidism conclusions older men reference interval tsh older men shifted upward whereas reference interval compressed compared conventional reference ranges applying reference intervals based healthy older men identifies substantial number older men overt thyroid disease subclinical hyperthyroidism reduces number classified subclinical hypothyroidism
paper describes second part series investigation develop algorithms simultaneous retrieval aerosol parameters surface reflectance future hyperspectral geostationary satellite sensors tropospheric emissions monitoring pollution tempo information content hyperspectral measurements analyzed principal components pcs surface spectra total aerosol parameters describe columnar aerosol volume total fine mode aerosol volume fraction size distribution wavelength dependent index refraction coarse fine mode aerosols forward simulations atmospheric radiative transfer conducted surface types green vegetation bare soil rangeland concrete mixed surface case wide range aerosol mixtures shown pcs surface spectra atmospheric window channel could derived top atmosphere reflectance conditions low aerosol optical depth aod relative error degree freedom signal analysis sequential forward selection method common bands different aerosol mixture types surface types selected aerosol retrieval first selected bands accounts information content aerosols pcs needed reconstruct surface reflectance however information content common bands tempo individual observation insufficient simultaneous retrieval surface weight coefficients multiple aerosol parameters total contrast multiple observations location tempo multiple consecutive days additional aerosol parameters could retrieved consequently self adjustable aerosol retrieval algorithm account surface types aod conditions multiple consecutive observations recommended derive aerosol parameters surface reflectance simultaneously tempo elsevier ltd rights reserved
objectives analysis headache occurrence national cohort patients acute stroke methods data based triennial month period national acute stroke israeli nasis registry total patients acute stroke retrieved ischemic stroke intracerebral hemorrhage ich sinus vein thrombosis svt stroke type undetermined results two hundred six patients reported headache svt headache reported patients ich patients transient ischemic attack tia complained headache patients headache stroke type undetermined female gender younger age previous headache cerebral hemorrhage dizziness unsteadiness predisposed headache incidence headache higher patients ich patients regardless history previous headaches headache decreased stroke severity common posterior anterior circulation patients lacunar stroke suffered less frequently headache patients non lacunar stroke significantly patients carotid dissection presented headache without conclusions intracerebral hemorrhage younger age female gender posterior circulation involvement headache history predictors headache occurrence acute stroke headache incidence ich correlates stroke severity opposed headache tia unusual lacunar strokes generally accompanied headaches headache remains main complaint svt carotid dissection
objective objective study investigate association lupus nephritis organ damage mortality patients systemic lupus erythematosus sle methods total patients sle investigated lupus nephritis defined proteinuria based american college rheumatology criteria damage assessed using systemic lupus international collaborating clinics american college rheumatology damage index associations lupus nephritis overall non renal corticosteroid associated non associated damage analyzed using logistic regression age adjusted sex adjusted standardized mortality ratio evaluated patients without lupus nephritis results prevalence lupus nephritis patients sle patients lupus nephritis higher percentage overall cumulative damage patients without lupus nephritis odds ratio adjusting age sle diagnosis sex disease duration anti malarial agents immunosuppressive agents cumulative corticosteroid dose among non renal damage odds corticosteroid associated damage higher confidence interval whereas odds non associated damage lower patients lupus nephritis standardized mortality ratios patients without lupus nephritis respectively conclusion patients sle presence lupus nephritis associated increased corticosteroid associated damage less corticosteroid non associated damage also mortality significantly higher patients lupus nephritis without lupus nephritis
cortical functioning within default mode network dmn salience network altered chronic pain patients mechanisms underlying alterations unknown novel unexamined source cross network communication aberrant functional connectivity dmn whose activity normally anticorrelated reflects disease severity many brain disorders stronger posterior cingulate cortex pcc anterior insula reported chronic pain pointing abnormal dmn interactions tested hypothesis cross network dmn abnormal chronic pain related pain associated symptoms used resting state fmri examine within dmn patients chronic pain due ankylosing spondylitis healthy controls whole network analysis revealed compared healthy controls patients exhibited less anticorrelated dmn degree cross network abnormality tracked pain disease related symptoms suggests cross network metric functional brain abnormality chronic pain complementary seed based analysis pcc strongly connected weakly connected dmn chronic pain compared healthy controls suggesting pcc acts hub altered network interaction sensorimotor cortex cross network correlated measures physical function suggesting physical functioning also impacts brain network interaction chronic pain study implicates altered communication brain networks key factor underlying chronic pain
objective current descriptions psychiatry psychology suggest depressed mood clinical depression similar mild sadness experienced everyday life intense persistent evaluated concept using measures average mood mood instability method prospectively measured low high moods using separate visual analog scales twice day seven consecutive days participants four published studies participants divided non depressed group beck depression inventory score determined mean square successive difference statistic results mean low high moods correlated non depressed group strongly positively correlated depressed group difference correlations significant low high weakly positively correlated non depressed group strongly positively correlated depressed group difference correlations also significant conclusion results show low high moods low high highly correlated people depression compared depressed current psychiatric practice assess treat brief high mood episodes patients depression new models mood also focus need developed address pattern mood disturbance people depression
calculation sample size needed clinical study challenge frequently put statisticians one relevant issues study design correct size study sample optimizes number patients needed get result detect minimum treatment effect clinically relevant minimizing sample size study advantage reducing costs enhancing feasibility also ethical implications brief report explore main concepts sample size calculation based
paper presents new pole zero assignment based design method two degree freedom pid controller applicable positioning tracking drives linear servo motors method uniquely determine five pid control parameters giving five items namely mover mass maximum load mass thrust constant cutoff frequency position control system crossover frequency sensitivity complementary sensitivity functions pole angle plane simulation experimental results validate proposed method
aims overuse medications used treat migraine headache increase frequency headaches sudden abstinence migraine medication also lead period withdrawal induced headaches aim study examine effect morphine withdrawal localized rostral ventromedial medulla rvm activity dura sensitive spinal trigeminal nucleus caudalis neurons methods rats implanted either morphine placebo pellets six seven days microinjection naloxone methiodide phosphate buffered saline rvm urethane anesthetized animals dura sensitive neurons recorded production fos like immunoreactivity quantified results chronic morphine treated animals naloxone methiodide microinjections produced significant increase ongoing facial heat evoked activity increase fos positive neurons nucleus reticularis dorsalis brainstem region involved diffuse noxious inhibitory controls conclusions results indicate activation pronociceptive neurons rvm conditions morphine withdrawal increase activity neurons transmit headache pain modulation subnucleus reticularis dorsalis rvm may explain attenuation conditioned pain modulation patients chronic headache
study presents animal mobility system equipped positioning running wheel prw way quantify efficacy exercise activity reducing severity effects stroke rats system provides effective animal exercise training commercially available systems treadmills motorized running wheels mrws contrast mrw achieve speeds min rats permitted run stable speed min spacious high density rubber running track supported wide acrylic wheel diameter work using predefined adaptive acceleration curve system reduces operator error also trains rats run persistently specified intensity reached way evaluate exercise effectiveness real time position rat detected four pairs infrared sensors deployed running wheel adaptive acceleration curve initiated using microcontroller data obtained infrared sensors automatically recorded analyzed computer comparison purposes week training conducted rats using treadmill mrw prw surgically inducing middle cerebral artery occlusion mcao modified neurological severity scores mnss inclined plane test conducted assess neurological damages rats prw experimentally validated effective among animal mobility systems furthermore exercise effectiveness measure based rat position analysis showed high negative correlation effective exercise infarct volume employed quantify rat training type brain damage reduction experiments
ankle sprains common team sports sports played courts often result structural functional alterations lead greater reinjury risk speciic exercises often used promote neuromuscular improvements prevention rehabilitation ankle injuries literature review summarizes neuromuscular characteristics common ankle sprains effectiveness exercise intervention improving neuromuscular function preventing reinjury review found appropriate exercise prescription increase static dynamic balance decrease injury recurrence particular addition dynamic activities exercise program beneicial anticipatory postural adjustments identiied key factor injury mechanism
relationship shear environment physiological characteristics plant cells always crucial challenging aspect scale suspension cultivations work propose quantitative method evaluating lethal effects hydrodynamic carthamus tinctorius cell computational fluid dynamic cfd technology online capacitance viable cell detection study towards effect short term shear force tinctorius cells carried bioreactor various overall shear intensities online capacitance electrode applied count dynamic vital cell first order kinetic model achieved describe death rate time span min based capacitance product maximum shear stress shear frequency ssf parameter evolution energy dissipation circulation function established relate cell death rate shear environment good correlation cell death kinetics ssf parameter observed verification test str bioreactor ssf used determine maximum operating range hydrodynamic stress improve design optimization tinctorius cultivation scale process elsevier rights reserved
background ketogenic diet used treatment resistant epilepsy since researched variety neurological conditions animal models human trials aim review clarify potential role psychiatry methods narrative review electronic databases pubmed psychinfo scopus results search yielded studies related use mental disorders including anxiety depression bipolar disorder schizophrenia autism spectrum disorder asd attention deficit hyperactivity disorder adhd studies comprised nine animal models four case studies two open label studies humans anxiety exogenous ketone supplementation reduced anxiety related behaviors rat model depression significantly reduced depression like behaviors rat mice models two controlled studies bipolar disorder one case study reported reduction symptomatology second case study reported improvement schizophrenia open label study female patients reported reduced symptoms weeks single case study reported improvement brief report weeks mouse model normalized pathological behaviors asd open label study children reported significant improvement one case study reported pronounced sustained response asd four controlled animal studies significantly reduced asd related behaviors mice rats adhd one controlled trial dogs comorbid epilepsy conditions significantly improved conclusion despite long history neurology role mental disorders unclear half published studies based animal models mental disorders limited generalizability analog conditions humans review lists major limitations including lack measuring ketone levels four studies issue compliance rigid diet humans currently insufficient evidence use mental disorders recommended treatment option future research include long term prospective randomized placebo controlled crossover dietary trials examine effect various mental disorders
recent research suggested improving fine grained datalocality one main approaches improving energy efficiency performance however previous research investigated effect approach metrices case concurrent data structures paper investigates fine grained data locality influences energy efficiency performance concurrent search trees crucial data structure widely used several important systems conduct set experiments three lock based concurrent search trees deltatree portable fine grained localityaware concurrent search tree cbtree coarse grained localityaware tree bst locality oblivious concurrent search tree run experiments commodity platform embedded arm platform experimental results show deltatree better energy efficiency operations second arm platforms respectively results confirm portable fine grained locality improve energy efficiency performance concurrent search trees
background patient discomfort secondary indwelling urethral catheter post operative period distressing symptoms resemble overactive bladder oab syndrome muscarinic receptor blockers successful management oab however information use drugs management postoperative catheter related bladder discomfort crbd sub saharan africa still relatively sparse objective assess efficacy preoperative oral tolterodine management crbd surgical patients immediate postoperative period methods double blind placebo controlled study consisting patients arm underwent general anesthesia patient given oral tolterodine placebo hour induction anesthesia patient later assessed recovery room intervals recovery anesthesia presence crbd noted graded results overall incidence crbd tolterodine group control respectively overall tolterodine prophylaxis associated absolute risk reduction arr relative risk reduction rrr number needed treat nnt incidence moderate severe crbd tolterodine control groups respectively arr conclusion significantly reduce incidence crbd immediate postoperative period appears efficient reduction severity postoperative crbd
big data jobs usually executed large scale distributed computing platforms automatically divide job multiple computation phases contains number independent tasks run parallel data shuffling process two consecutive phases becomes bottleneck job execution improve performance approach push shuffling proposed send intermediate results next phase immediately generated avoids local disk accesses traditional pull shuffling approach tasks next phase start data processing without waiting tasks predecessive phase finish task duplication another approach accelerate task execution launching multiple task copies compete processing data block push shuffling meets task duplication big data jobs significantly accelerated leading large amount redundant data transmission two phases address challenge propose software define data shuffling approach designing controller janitor module control data shuffling process task janitor communicates controller request admission permit sending intermediate results next stage tasks propose online grouping algorithm reduce overhead frequent communication controller performance proposed algorithm evaluated extensive simulations
objective osteoporosis become critical public health problem rapidly aging population japan necessary dentists know patients status influences dental treatment purpose study predict risk osteoporosis elderly patients visiting dental clinic assessing mandibular cortical morphology panoramic radiographs method three hundred thirty patients divided three classes based morphology mandibular cortex panoramic radiographs mandibular cortical bone width mental foramen also measured bone mineral density bmd determined calcaneus using quantitative ultrasound device results mandibular cortical width decreased significantly class normal cortex class moderately eroded cortex class severely eroded cortex bmd negatively correlated age female male patients female patients class cortex low bmd among women mandibular cortical width significantly correlated bmd thirty three percent female received previous diagnosis osteoporosis contrast male class cortex men mandibular cortical width significantly correlate bmd men received previous diagnosis osteoporosis number remaining teeth correlate low bmd either sex conclusion findings reveal elderly female patients visiting dental clinic high risk osteoporosis low bmd
whereas recent reports national studies presented extremely high rates many personality disorders american indian communities persistent concerns meaning symptoms left many troubled reports american indians group known suffer disproportionately number violent experiences dynamics violence received little attention paper examines perspectives violence lives northern plains tribal members met criteria antisocial personality disorder comorbid alcohol use disorder explores study participants constructed understood violent encounters well motivations described characterized reputation leveling retaliation catharsis self defense violence gendered study men generally presenting perpetrators women victims men often described ready participants violent world women quite clear aggression often simply required tried defend male violence analysis replace clinical analyses violence antisocial personality disorder reveal underlying cultural logic may play role shaping recourse violence minority individuals appears obvious choice
prophylaxis effective strategy eradicate deficiency disorders shown affect thyroid disease pattern study assessed frequency thyroid disorders adult population living two areas southern italy implementing prophylaxis aim cross sectional population based study including subjects deficient rural sufficient urban area southern italy conducted thyroid ultrasound performed participants urine blood samples collected subject levels thyroid stimulating hormone tsh thyroglobulin tgab thyroperoxidase antibodies tpoab urinary excretion uie thyroid volume echogenicity evaluated found median uie higher urban rural area whereas prevalence subjects affected goitre higher rural compared urban area positive tgab rather tpoab frequent subjects urban area compared rural area hypoechoic pattern thyroid ultrasound similar two areas tgab significantly higher subjects urban area frequency elevated tsh differ two screened populations changes found tgab positivity subjects high tsh urban compared rural area findings support small risks supplementation far outweighed substantial benefits correcting deficiency although continued monitoring populations necessary
location transportation new category united states green building council leadership energy environmental design leed rating system location transportation category emphasizes walkability includes strategies reduce resources related transporting people leed recognizes critical opportunity reduce impacts costs pollution depletion resources influence people within built environment based building close proximity amenities alternative transportation options addition strategies aim increase health welfare building occupants promoting walkability research follows focuses building location terms surrounding density diverse uses relates health aspects increased walkability rather automobile use decreased dependencies automobiles thought correlate decrease body mass index bmi individuals specifically research utilizes cross sectional survey collect data bmi automobile use residents urban infill housing project downtown los angeles california data collected winter bmi dependent variable automobile use independent variable
introduction aerobic gymnastics since membership international gymnastics federation undergone changes regulations objective analyze injuries found spanish aerobic gymnastics athletes different editions code points methods descriptive longitudinal comparative study carried epidemiology injuries aerobic gymnastics published different editions code points results highlights number injuries decreased last year decline related restriction number difficulties exercise number elements performed floor however increased number value difficulties conclusions therefore concluded changes made regulations intended safeguard health athletes ensure competition develops best artistic technical aspect
impairments interpersonal relationships core feature borderline personality disorder bpd social cognition dysfunction like false recognition others emotions intentions may lead emotional disturbances self injury impulsive aggression behaviors patients bpd study explored extent social cognition including emotional recognition theory mind tom predict ability social awareness patients bpd emotion recognition tasks matching emotional facial expressions prosody verbal nonverbal theory mind tasks awareness social inference test assessed results stepwise multiple regression showed quality early parent child relationship anger prosody recognition tom significantly related ability aware social interactions patients bpd
glial cell line derived neurotrophic factor gdnf potent neurotrophic factor substantia nigra dopaminergic neuronal cells recent studies demonstrated neural cell adhesion molecule functions signal transduction receptor gdnf purpose study reveal whether neural cell adhesion molecule ncam mediates protective effects gdnf neuronal cells explore mechanisms involved utilized syy cell line establish model hydroxydopamine ohda injured neuronal cells lentiviral vectors constructed knockdown overexpress ncam density gradient centrifugation method employed separate membrane lipid rafts dimethythiazol diphenyl tetrazolium bromide mtt flow cytometric analysis western blotting used evaluate protective effects gdnf results showed gdnf could protect ohda injured syy cells via improving cell viability decreasing cell death rate cleaved caspase expression ncam knockdown decreased cell viability increased cell death rate cleaved caspase expression overexpression opposite effects notably amount ncam located lipid rafts increased gdnf treatment pretreatment bromopalmitate specific inhibitor protein palmitoylation suppressed ncam translocation lipid rafts reduced ncam mediated protective effects gdnf injured neuronal cells results suggest gdnf protective effects injured cells influencing ncam translocation lipid rafts
developed simple method prepare hybrid copper silver conductive tracks flash light sintering developed metal nanoparticle based ink convenient preparation process free tedious washing steps inks composed commercially available copper nanoparticles mixed formic acid silver nitrate diethylene glycol role formic acid remove native copper oxide layer surface copper nanoparticles way facilitates formation silver outer shell surface copper nanoparticles galvanic replacement presence formic acid copper nanoparticles formed copper formate present unsintered tracks however illumination xenon flash light copper formate converted copper moreover resistance copper films increased orders magnitude oxidized high temperatures similar degrees however addition silver nitrate inks suppressed oxidation hybrid copper silver films resistance changes inks high temperatures greatly reduced addition hybrid inks proved advantageous use electrical circuits demonstrated stable electrical conductivity exposure ambient air degrees
background basic task bioinformatics counting mers genome sequences existing mer counting tools often optimized small software result intensive process algorithm engineering implements two step approach first step genome reads loaded disk redistributed temporary files second step mers temporary file counted via hash table approach addition basic functionality gerbil optionally use gpus accelerate counting step set experiments real world genome data sets show gerbil able efficiently support small large conclusions gerbil performance comparable existing state art open source mer counting tools small vastly outperforms competitors large thereby enabling new applications require large values
internal quality intact persimmon rojo brillante assessed trough visible near infrared hyperspectral imaging fruits three stages commercial maturity exposed different treatments obtain fruit different ripeness level astringency soluble tannin content spectral spatial information used building classification models predict ripeness astringency trough multivariate analysis techniques like linear quadratic discriminant analysis lda qda support vector machine svm additionally flesh firmness predicted partial least square regression plsr full spectrum used determine internal properties later principal component analysis pca used select optimal wavelengths correct classification three classifiers case ripeness qda case astringency value ratio prediction deviation rpd obtained selected wavelengths prediction firmness demonstrated potential hyperspectral imaging non destructive tool assessment firmness ripeness state astringency level rojo brillante persimmon elsevier ltd rights reserved
introduction despite rollout antiretroviral therapy art challenges remain ensuring timely access care treatment people living hiv part multi country study investigate hiv mortality conducted health facility surveys within health demographic surveillance system sites across six countries eastern southern africa investigate clinic level factors influencing use hiv testing services use hiv care treatment iii patient retention art methods health facilities sampled within surveillance sites nairobi kisumu kenya karonga malawi agincourt umkhanyakude south africa ifakara kisesa tanzania kyamulibwa rakai uganda manicaland zimbabwe structured questionnaires administered charge staff members hiv testing prevention mother child transmission pmtct art units within facilities forty one indicators influencing uptake patient retention along continuum hiv care compared across sites using descriptive statistics results number facilities surveyed ranged six malawi zimbabwe eighty percent governmentrun lower level facilities district referral hospitals client load varied widely less one hiv testing clients per provider per week facilities delivered services interventions would support patient retention care delivering free services offering pmtct within antenatal care pre art monitoring adherence counselling many facilities delivered several areas however targeted testing high risk groups mobile testing also intra site inter site differences including delivery option ranging kisumu kyamulibwa nurse led art initiation ranging kisesa karonga agincourt facilities malawi require additional lab tests art initiation stock outs hiv test kits antiretroviral drugs particularly common tanzania conclusions identified high standard health facility performance delivering strategies may support progression continuum hiv care hiv testing policy practice particularly weak inter intracountry differences quality coverage represent opportunities improve delivery comprehensive services people living hiv
spectral methods efficient way solve partial differential equations domains possessing certain symmetries utility method depends strongly choice spectral basis paper describe set bases built jacobi polynomials associated operators solving scalar vector tensor partial differential equations polar coordinates unit disk construction bases satisfy regularity conditions tensorial field coordinate singularity disk prototypical case many coordinate singularities work presented extends geometries operators represent covariant derivatives multiplication azimuthally symmetric functions tensorial relationship fields arise naturally relations classical orthogonal polynomials form heisenberg algebra past work uses specific polynomial bases solving equations polar coordinates main innovation paper use larger set possible bases achieve maximum bandedness linear operations provide series applications methods illustrating ease use accuracy elsevier inc rights reserved
empathic functioning inhibitory control deficits two symptoms antisocial personality disorder aspd despite deleterious effects limited research exists interventions would ameliorate specific symptoms suggest meditative interventions may help increase empathic functioning inhibitory control aspd individuals using luria working brain framework present research showing meditative interventions influence brain regions associated empathic functioning inhibitory control implications counseling profession directions research discussed
maria montessori one well known women italian history although first woman graduated medicine italy mostly known educator teaching method montessori method still used worldwide could speak english imprisonment india big obstacle communication children however need adopt non verbal communication led sensational discovery children use innate universal language language made gestures mimic called extra verbal communication
background financial literacy managing personal finances health literacy managing personal health become increasingly important older adults potentially impacting quality life resources constructs literacy tend distinct although skills decision making involved overlap financial issues impact healthcare choices thus primary purpose commentary propose new area research focus defines intersection financial health literacy financial health literacy methods conducted limited literature review related financial health health insurance literacy demonstrate gaps literature support position online search engines utilized identify research primary areas interest results define intersection financial health literacy area need labeled financial health literacy focus four domains include ability manage healthcare expenses pay medical bills determine health needs understand treatment options make sound healthcare decisions financial resources available despite overlap health insurance literacy financial health literacy would define area need encompassing health management choices health plan selections integrated financial management issues including living arrangements financial planning retirement planning conclusions potential initiatives considered help risk older adults find resources improve financial health literacy turn enhance abilities manage medical choices environment increasingly complex healthcare system
background patients impaired renal function show high incidence bone mineral disturbances chronic kidney disease mineral bone disorders ckd mbd range high turnover osteoporosis adynamic bone disease currently histomorphometric analysis bone biopsy taken iliac crest viewed gold standard ckd mbd subtype differentiation however clinical relevance biopsy questionable since iliac crest fractures extremely rare finding therefore aimed elucidate histomorphometric parameter trabecular bone volume iliac crest representative biopsy locations chose two skeletal sites higher fracture risk testing namely tibial bone lumbar spine examine current gold standard bone biopsy indeed golden methods bone biopsies taken embalmed body donors iliac crest proximal tibia lumbar vertebral body respectively masson goldner stained sections methyl methacrylate embedded biopsies used trabecular bone volume calculation furthermore exemplary computed tomography xtremect scans subsequent analysis performed results median values trabecular bone volume comparable body donors median interquartile range iqr iliac crest proximal tibia lumbar spine however single values showed extensive intra individual variation also confirmed xtremect imaging conclusions distinct intra individual heterogeneity trabecular bone volume elucidate bone biopsy one site necessarily predict patient relevant endpoints like hip spine fractures physicians interpreting bone biopsy results know limitation current gold standard ckd mbd diagnostic especially systemic therapeutic decisions based
diabetes mellitus associated electrical remodeling heart increasing risk arrhythmias however knowledge electrical remodeling sinoatrial node san limited investigated expression hcn channel isoforms hcn hcn san streptozotocin stz induced diabetic rats age matched controls found stz induced diabetic rats lower intrinsic heart rate lengthened sinoatrial conduction time rate corrected maximal sinoatrial node recovery time vivo well longer cycle length vitro compared control optical mapping san demonstrated inferior leading pacemaker site reduced san conduction velocity diastolic depolarization slope longer action potential duration stz induced diabetic rats control transcripts proteins hcn hcn diabetic san reduced specific blockade hcn channels mol ivabradine significantly prolonged langendorff heart diabetic rats control reduced expression hcn channel isoforms san stz induced diabetic rat may important contributor reduced san function
increasing population living cities leading higher resource utilization strains cities ability focus sustainability adoption different technologies transform cities smart cities utilize energy efficiently paper presents results technology assessment tool developed together six mid sized european cities main areas focus evaluated based cities priorities transportation public private consumers perspectives use smart electricity meters use electric vehicles sweden techno economic evaluation biogas derived biomethane electricity use public transportation analyzed main conclusions show overall higher efficiency biogas derived electricity use electric buses need higher consumer engagement detailed information provision increasing market penetration electricity savings need establish detailed technology assessments successful technology adoption cities elsevier ltd rights reserved
ability distinguish peatland types landscape scale implications inventory conservation estimation carbon storage fuel loading postfire carbon emissions among others paper presents multisensor multiseason remote sensing approach delineate boreal peatland types wooded bog open fen shrubby fen treed fen using combination multiple dates band synthetic aperture radar sar alos palsar band similar ers ers landsat optical remote sensing data imagery first evaluated small test area boreal alberta canada determine feasibility using multisensor sar optical data discriminate peatland types object based machine learning classification algorithms applied million peatland rich subregions alberta canada million region michigan upper peninsula peatlands less dominant accuracy assessments based field sampled sites show high overall map accuracies alberta michigan exceed previous mapping efforts
resources large scale distributed systems distributed among several autonomous domains domains collaborate produce significantly higher processing capacity load balancing however resources domain tend cooperative whereas different domains self interested fairness key collaboration self interested environment accordingly fairness aware load balancing algorithm proposed load balancing problem defined game nash equilibrium solution problem minimizes expected response time maintaining fairness furthermore reinforcement learning used search nash equilibrium compared static approaches algorithm require prior knowledge job arrival execution adapt dynamically processes synthesized tests indicate algorithm close optimal scheme terms overall expected response time different system utilization heterogeneity system size also ensures fairness similar proportional scheme trace simulation conducted using job workload log scalable powerpalle system san diego supercomputer center algorithm increases expected response time maximum improves fairness contrast opportunistic load balancing minimum execution time minimum completion time switching algorithm percent best elsevier rights reserved
integrated circuits design research laboratory southern illinois university edwardsville siue collaborating past several years nuclear reactions group washington university development family custom multi channel integrated circuits ics date collaboration successfully produced two micro chips first analog shaped peak sensing chip known hinpc heavy ion nuclear physics channel second chip christened psdc pulse shape discrimination channel designed logically complement terms detector types hinpc chip hinpc chip use solid state detectors produces sparsified analog pulse trains linear pulse height timing relative external reference signals shaper peak detector implemented linear branch pseudo constant fraction discriminator cfd time voltage converter tvc implemented logic timing branch internal external gain options make chip suitable use wide variety applications psdc greatly simplifies pulse processing electronics needed large arrays scintillation detectors psdc employs user controlled multi region charge integration particle identification inherent design three pulse height sub channels consists gated integrator eight programmable charging rates externally programmable gate generator defines start time ranges width time ranges gate relative external discriminator signal moreover channel chip also contains tvc paper describes design capabilities features hinpc psdc ics along description chips used also discusses modifications enhancements made chips associated prototypical systems order improve ease use increase performance
background hypothyroidism frozen shoulder associated although relationship remains uncertain main objective study determine prevalence hypothyroidism patients methods case control study performed compare patients cases patients visited orthopedic service clinical conditions controls diagnosed according specific criteria based anamnesis physical examination shoulder radiographs specific questionnaire applied measurements serum thyroid stimulating hormone tsh free tetraiodothyronine performed subjects results evaluated shoulders patients controls prevalence hypothyroidism diagnosis significantly higher group also tendency higher prevalence bilateral among patients elevated tsh levels mean serum tsh levels higher patients bilateral compared unilateral compromise higher patients severe compared mild moderate together multivariate analysis showed independently related diagnosis hypothyroidism odds ratio trend toward independent association high serum tsh levels severe odds ratio bilateral odds ratio compromise conclusion prevalence hypothyroidism significantly higher patients controls results suggest higher serum tsh levels associated bilateral severe cases journal shoulder elbow surgery board trustees rights reserved
purpose management late onset hypogonadism loh homogenous aim study observe management patients low testosterone highly specialized italian centres methods siamo noi observational longitudinal disease registry evaluation clinical management patients low levels total nmol calculated free pmol already treatment italian centers members italian society andrology sexual medicine siams clinical biochemical data collected four visits months observation results patients mean age years enrolled men receiving androgen therapy whereas naive first visit men started androgen therapy whereas remained untreated entire observation younger age odds ratio total nmol complaining least one sexual symptom reporting severe lower urinary tract symptoms predicted starting androgen therapy sixty four men started therapy immediately maintained observation end compared reported increase domains international index erectile function iief sexual physical subdomains aging male scale well international prostate symptom score conversely untreated group reported significant improvement although lower treated group erectile function domain iief conclusions management loh siams centres line international guidelines newest knowledge role prostate health androgen therapy associated improvement aspects sexual life perception physical strength
streptozotocin widely used mimic aspects alzheimer disease however especially mice several characteristics involved streptozotocin stz induced pathology well known main purpose study evaluate temporally expression related proteins amyloid beta beta choline acetyltransferase chat synapsin axonal neurofilaments phosphorylated tau hippocampus following intracerebroventricular icv administration stz adult mice also analyzed impact stz short long term memory novel object recognition test male mice injected stz citrate buffer related proteins evaluated immunoblotting assays hippocampus days injection differences groups found days majority markers evaluated found altered days stz group showed increased amyloid beta protein neurofilament expression increased phosphorylation tau protein decreased synapsin expression levels compared controls except synapsin neurochemical changes transient last days stz injection moreover short term long term memory deficits demonstrated stz treatment days stz treatment
present society alzheimer disease common dementia form elderly people big social health problem worldwide paper propose novel multi view classification method based norm regularization alzheimer disease diagnosis unlike previous norm regularized methods using concatenated multi view features consider intra structure inter structure relations features different views use flexible norm regularization objective function also proposed suitable loss function measure loss labels predicted values classification task experimentally demonstrated method enhances performance disease status classification comparing state art methods
astronomical data always use cartesian coordinates sky observational data simulations rotationally symmetric systems accretion protoplanetary disks may use spherical polar coordinate systems standard displays rely cartesian coordinates converting non cartesian data cartesian format causes distortion data loss detail demonstrate method using standard techniques computer graphics avoids problems three dimensional data arbitrary coordinate systems method adds minimum computational cost display process suitable realtime interactive content producing fixed rendered images videos proof concept code provided works data spherical polar coordinates
study examined relationship different areas family need utilization home based post investigation services hbps following child protective services cps investigation sample consisted families children remained home initial cps investigation july april family need measured three areas concrete clinical educational using family assessment form faf families received one following hbps case management concrete educational clinical services pearson chi square analyses utilized identify significant areas needs included final multivariate logistic regression hbps controlling demographic characteristics numerous areas family need associated receipt services intended address needs specifically concrete need related financial conditions met concrete services educational need related child development indicator parenting need met educational services clinical need related interactions caregivers potential indicator domestic violence met clinical services contrast caregivers concrete need related living conditions less likely receive educational clinical services findings study highlight matching concrete needs related services relatively straightforward match educational clinical needs respective services complex discuss complexities matching different areas need hbps following cps investigation importance bridging services engage families risk maltreatment additional prevention services published elsevier ltd
hereditary angioedema due inhibitor deficiency hae inh characterized recurrent skin swellings abdominal pain attacks rarely potentially life threatening laryngeal attacks thus hae inh may associated significant morbidity mortality last years field research pathogenesis hae inh greatly expanded led new clinical trials new therapeutic options strategies managing hae inh aimed treating acute attacks preventing attacks use prophylactic treatment agents available treating acute attacks include plasma derived inh concentrates bradykinin receptor antagonist recombinant human inh usa plasma kallikrein inhibitor additionally approved longterm prophylactic treatments include attenuated androgens plasma derived inh concentrate antifibrinolytics plasma derived inh bradykinin receptor antagonist approved self administration home number management options hae inh increased considerably within last years thus helping alleviate burden disease
early adverse experiences precede long term negative effects physical health children experiencing armed conflict flight displacement refugee life may enhanced risk recent psychobiological models integrating knowledge perinatal childhood stress susceptibility chronic illnesses later life make clear pressing need protective provision war affected children experience multiple traumas continuing stressors increasing recognition mechanisms linking physical mental health adult diseases seen developmental disorders origins early life biological embedding models propose links early adversity increased vulnerability later disease premature death threat central children families whose lives changed war displacement may activate biological behavioural systems could increase risk long term ill health applying models understanding experiences refugees translation care provided ways monitoring protecting long term population health could potentially promote interventions reduce longer term secondary harms
individuals mild cognitive impairment mci show relative weaknesses executive functioning well poor memory inhibition related mechanisms behind impairment mci examined systematically aim present study systematically investigate inhibitory function individuals mci ascertain whether pathological aging characterized deficits inhibitory processes whether impairment confined specific inhibition related mechanisms tasks assessing inhibition related functions prepotent response inhibition measured color stroop test response distracters assessed using text distracters task resistance proactive interference assessed proactive interference task administered individuals mci healthy older controls individuals mci made intrusion errors proactive interference task controls two groups performance comparable prepotent response inhibition response distracters pattern findings suggests mci associated specific inhibition problems
substantial amount datasets stored various applications often high dimensional redundant irrelevant features processing analysing data circumstances time consuming makes difficult obtain efficient predictive models strong need carry analyses high dimensional data lower dimensions one approach achieve feature selection paper presents new relevancy redundancy approach called maximum relevance minimum multicollinearity mrmmc method feature selection ranking overcome shortcomings existing criteria proposed method relevant features measured correlation characteristics based conditional variance redundancy elimination achieved according multiple correlation assessment using orthogonal projection scheme series experiments conducted eight datasets uci machine learning repository results show proposed method performed reasonably well feature subset selection elsevier ltd rights reserved
full human body shape scans provide valuable data variety applications including anthropometric surveying clothing design human factors engineering health entertainment however high price large volume difficulty operating professional scanners preclude use home entertainment recently portable low cost red green blue depth cameras kinect become popular computer vision tasks however infrared mechanism type camera leads noisy incomplete depth images construct stereo full body scanning environment composed multiple depth cameras propose novel registration algorithm algorithm determines segment constrained correspondence two neighboring views integrating using rigid transformation furthermore aligns views based uniform error distribution generated mesh model typically sparse noisy even holes makes lose surface details address introduce geometric topological fitting prior form professionally designed high resolution template model formulate template deformation optimization problem fit high resolution model low quality scan solution overcomes obstacles posed different poses varying body details surface noise entire process free body template markers fully automatic achieves satisfactory reconstruction results
present study examined unstructured spending time friends workers structured attending social events place workshop sports teams social participation changed high school youth autism spectrum disorders asd well longitudinal concurrent relations social participation internalizing symptoms participants included families youth asd last year high school first time point data collection high school average months second time point social participation internalizing symptoms determined using parental report average change amount unstructured social participation high school exit although substantial individual variability observed participation structured social activities significantly declined high school exit youth structured social participation high school significantly likely gains unstructured social participation high school exit turning relationships internalizing social activities internalizing symptoms youth asd high school significantly predicted increasing social isolation high school exit terms structured unstructured activities results point likely need additional supports transition adulthood youth asd internalizing problems autism res international society autism research wiley periodicals inc autism res international society autism research wiley periodicals inc
alcohol drug use commonly associated experience homelessness order better understand explored prevalence drug alcohol use related successful housing within sample first time single homeless adults municipal shelters within sample compared features recurrent homelessness chronic homelessness stably housed interviewed subjects upon shelter entry followed one every six months months using standardized social mental health measures analyzed baseline assessments relative housing experiences follow using chi square multinomial logistic regression eighty one percent obtained housing months experienced homelessness recurrent homelessness common among high school education initially housed family bivariate analysis resulted observation highest rate alcohol drug use among recurrent group multinomial logistic regression supported coupling arrest history diagnosed antisocial personality disorder relatively high rates recurrent homelessness differences subjects experienced recurrent homelessness compared stably housed chronic homelessness alcohol substance use disorders associated recurrent homelessness linked risk factors highlights complexity causes homelessness resultant need organize constellations causal risk factors consistent initiatives span bureaucratic boundaries flexibly meet multiple complex service needs thus improving outcomes concerning episodes recurrent homelessness
integrating student centered learning strategies utilizing technology improve learning performance hands learning strategies reduce misconceptions engage students learning certain theories concepts reasons study aim study develop learning apparatus based arduino uno linx labview observed case transient phenomena circuit real time current voltage wave chart characteristic charging discharging capacitor semi automatic control results showed apparatus offers good opportunity used physics learning next study apparatus used specific learning strategy find effect student learning performance
using nationally representative data individual subjective views gender roles examine gender gap educational achievement turkey show cultural bias education girls fundamental factor behind low educational attainment socially conservative societies education reform turkey extended compulsory schooling years using reform natural experiment investigate impact reform effects mothers traditional views determining children educational attainment find reform helped reduce school dropout rates across country nevertheless regardless mother view gender roles reductions school dropout rates similar boys girls failing eliminate gender gap girls turkey excellent environment study effects societal gender roles since combines modernity traditionalism displays wide spectrum views gender roles also one developing countries gender gap detriment females still exists educational achievement
attributional style regarded core domain social cognition questions persist psychometric characteristics measures used assess one widely used assessment attributional style ambiguous intentions hostility questionnaire aihq two limitations aihq include possible restricted range resulting homogenous item scenarios use rater scores cumbersome time consuming score unknown incremental validity present study evaluated psychometric properties aihq concurrently testing changes aiming improve scale particular expansion number self report items removal rater scored items one hundred sixty individuals diagnosed schizophrenia healthy controls completed full aihq along measures symptoms functioning verbal intelligence aihq particularly self reported blame score demonstrated adequate internal consistency test retest reliability distinguished patients controls also significantly related clinically rated hostility suspiciousness symptoms correlated functional capacity even controlling verbal intelligence incremental validity analyses suggested higher number self report items strengthens relationships outcomes manner justifies expansion rater scored items mixed results providing additional information beyond self report aihq published elsevier ltd
amidst progressive development built environment energy electricity consumption construction building sectors contributes climatic change energy insecurity malaysia many sustainability tools schemes programs attempted address environmental issues initiatives would rather face challenges strategic planning therefore paper primary objective providing sdp descriptive strategy case building integrated project attempt would anticipate outcome could improve quality life environmentally socially economically hence indicating sustainable development published elsevier ltd
lawyers frequently use complex question forms multifaceted questions single questions contain true false proposition cross examining witnesses prior research shown use questions reduces testimonial accuracy present study extends research using forced fabrication paradigm chrobak zaragoza assess multifaceted questions might affect eyewitness suggestibility exposure misleading post event information consistent prior studies use multifaceted questions led lower accuracy simple questions novel finding multifaceted questions caused larger impairments performance among fabrication participants earlier suggestively interviewed control participants also provide preliminary evidence impairment caused multifaceted questions due consider two propositions simultaneously shift question focus fabricated event true event
predicting protein submitochondrial locations studied ten years dozen methods developed regard although mitochondrion four submitochondrial compartments existing studies considered three mitochondrial intermembrane space proteins always excluded studies however mitochondrial intermembrane space proteins recent release uniprot database think time incorporate proteins predicting protein submitochondrial locations proposed functional domain enrichment score used enhancement positional specific physicochemical properties method constructed high quality working dataset uniprot database dataset contains proteins four submitochondrial locations proteins multiple submitochondrial locations also included method achieved prediction accuracy proteins single location dataset benchmarking dataset method achieved comparable prediction performance state art methods results indicate intermembrane space proteins incorporated predicting protein submitochondrial locations evaluating method proteins multiple submitochondrial locations conclude method capable predicting multiple submitochondrial locations first report initio methods identify intermembrane space proteins also first attempt incorporate proteins multiple submitochondrial locations benchmarking dataset obtained emails corresponding author
background obesity common medical disorder dogs predispose number diseases human obesity risk factor development progression chronic kidney disease objectives investigate possible association weight loss plasma renal biomarkers kidney health animals thirty seven obese dogs lost weight included study methods prospective observational study three novel biomarkers renal functional impairment disease homocysteine cystatin clusterin addition traditional markers chronic renal failure serum urea creatinine urine specific gravity usg urine protein creatinine ratio upcr urine albumin corrected creatinine uac weight loss dogs naturally occurring obesity investigated results urea usg greater weight loss loss whilst upcr uac creatinine less weight loss respectively homocysteine cystatin clusterin decreased upon weight loss multiple linear regression analysis revealed associations percentage weight loss greater weight loss lean tissue loss loss plasma clusterin concentration greater clusterin lean tissue loss conclusion clinical importance results suggest possible subclinical alterations renal function canine obesity improve weight loss work required determine nature alterations notably reason association loss plasma clusterin subsequent lean tissue loss weight management
background female urinary microbiota associated urgency urinary incontinence response medication urinary microbiota women stress urinary incontinence described objective sought study cross sectional relationships urinary microbiota features demographic clinical characteristics women undergoing stress urinary incontinence surgery study design preoperative urine specimens collected women without urinary tract infection available women voided catheterized enrolled multicenter prospective randomized trial value urodynamic evaluation study demographic clinical variables obtained including stress urgency urinary incontinence symptoms menopausal status hormone use bacterial composition urine qualitatively assessed sequencing bacterial ribosomal rna gene phylogenetic relatedness microbial alpha diversity compared demographics symptoms using generalized estimating equation models results majority urine samples detectable bacterial dna bacterial diversity significantly associated higher body mass index increased medical epidemiologic social aspects aging urge index score hormonal status associations detected stress urinary incontinence symptoms increased diversity also associated concomitant lower frequency lactobacillus hormone negative women conclusion women undergoing stress urinary incontinence surgery detectable urinary microbiota cross sectional analysis revealed increased diversity microbiota associated urgency urinary incontinence symptoms hormonal status body mass index contrast female urinary microbiota associated stress urinary incontinence symptoms
paper propose algebraic language called time aglotos dedicated express bdi agent plans according features requirements ambient intelligence ami systems plan expressions written composed using time aglotos plans built automatically fly system concurrent processes language describes time dependent behavior agent provides theoretical foundation performing planning timing constraints taking account duration actions also allows express behavioral capabilities communication mobility cooperation context show achieve powerful mechanism contextual guidance based specific formal construction called contextual time planning system ctps
one child policy economic development annual rise anxious emotions behavioral problems among students learning difficulties order evaluate relationship anxious emotions behavioral problems study adopted quantitative approach randomly select elementary school students jiangsu province china screened anxious children learning disabilities conclusions research follows children learning difficulties anxious emotions behavioral problems average notably social phobia learning problems behavioral problems children learning difficulties varied due demographic variables significant interaction effect rearing styles family atmospheres children behavioral problems separation anxiety social phobia generalized anxiety disorder family atmosphere harmony rearing style democracy parental expectation self sufficiency somatization panic disorder children learning difficulties could predict behavioral problems based results study proposed suggestions educators future researchers
study investigates whether augmentation cognitive behavior therapy cbt fluoxetine improves outcomes anxious school refusing adolescents years sixty two participants randomly allocated cbt alone cbt fluoxetine cbt placebo treatments well tolerated one suicide attempt cbt placebo group groups improved significantly primary school attendance secondary outcome measures anxiety depression self efficacy clinician rated global functioning gains largely maintained months year participants anxiety disorder free acute treatment follow period anxiety depressive disorders continued decline whilst school attendance remained stable around significant group difference greater adolescent reported treatment satisfaction cbt fluoxetine group cbt alone group results indicate chronicity school refusal need future research best improve school attendance rates
platelets critical hemostasis thrombosis upon detecting injury platelets show range responses including release protein cargo alpha granules cargo synthesized platelet precursor megakaryocytes endocytosed megakaryocytes platelets insights alpha granule biogenesis come studies hereditary conditions granules immature deficient absent studies arthrogryposis renal dysfunction cholestasis arc syndrome identified first proteins essential alpha granule biogenesis vpsb vpsb vpsb vpsb form complex absence either platelets lack alpha granules granule specific membrane protein selectin gray platelet syndrome gps platelets also lack conventionally recognizable alpha granules although selectin containing structures present gps arises mutations affecting nbeal gps phenotype benign arc syndrome cause life threatening bleeding progressive thrombocytopenia myelofibrosis review essential roles vpsb vpsb nbeal granule development also examine existing data mechanisms action many details remain poorly understood vpsb vpsb ubiquitously expressed arc syndrome multisystem disorder causes lethality early life thus vpsb vpsb clearly involved processes besides alpha granule biogenesis studies involvement vesicular trafficking protein interactions reviewed gain insights roles alpha granule formation nbeal mutations primarily affect megakaryocytes platelets little known nbeal function insights gained studies related proteins lyst
bertossi proposed data cleaning technique based matching dependences matching functions practice intractable cases application matching dependences random orders moreover result application single matching dependence dirty database instance set clean instances depending number dirty tuples results high computational overhead well large space requirement aim paper propose improvement bertossi approach based abstract interpretation framework yields single clean abstract database instance sound approximation possible concrete clean instances convergence cleaning process also guaranteed using widening operators abstract domain proposal improves significantly efficiency performance query systems bertossi one
herpesviruses stand capacity establish lifelong infections immunocompetent hosts generally without causing overt symptoms herpesviruses equipped sophisticated immune evasion strategies allowing viruses persist life despite presence strong antiviral immune response although viral evasion tactics appear target virtually stage innate adaptive host immune response detailed knowledge available molecular mechanisms underlying herpesvirus obstruction mhc class restricted antigen presentation cells opens way clinical application review discuss recent efforts exploit human herpesvirus mhc class evasion strategies rational design novel strategies vaccine development cancer treatment transplant protection gene therapy immunology cell biology doi icb published online february
background nurse family partnership nurse home visitation program aims improve lives young mothers children program focuses women parenting first time experiencing socioeconomic disadvantage nurse visits start early pregnancy possible continue child reaches age two years program proven effective united states improving children mental health development maternal wellbeing showing long term cost effectiveness known whether benefits obtained canada public services differ british columbia healthy connections project therefore involves randomized controlled trial evaluating nurse family partnership effectiveness compared existing usual services improving children mental health early development mother life circumstances trial main aims reduce childhood injuries age two years primary outcome indicator reduce prenatal nicotine alcohol use improve child cognitive language development behaviour age two years reduce subsequent pregnancies months postpartum potential explanatory factors maternal mental health including self efficacy also assessed program impact exposure intimate partner violence inform future economic evaluation data also collected health social service access use methods design eligible consenting participants recruited prior weeks gestation individually randomized receive existing services comparison group nurse family partnership plus existing services intervention group nurse family partnership delivered following fidelity guidelines data collected person telephone interviews baseline weeks gestation two months postpartum additional data obtained via linkages provincial datasets recruitment commenced october continue approximately three years discussion trial provide important information generalizability nurse family partnership canadian context findings published peer reviewed journals shared policymakers practitioners extensive public health collaborations already underway
catering children food allergies school canteens falls entirely within ambit individualised meal project pad although national educational staff enjoy support medical personnel canteen staff prepare occasionally package meals employed local authorities thus rarely undergo training good practices catering children food allergies franche comte ecology network menu allergologie franche comte raft created proposes training staff present article sets methodology course tools developed evaluation date training sessions conducted region enabled training staff members institutions dealing small children secondary schools evaluation questionnaire comprising questions enabling collection spontaneous comments sent primary school staff underwent training sixty one questionnaires completed majority staff answering questionnaire indicated acquired new knowledge particular regarding allergen labeling greater working knowledge procedures recommended pai felt better prepared catering children food allergies better understanding various people involved training able cater successfully children food allergies without offering separate meals population success project partly due creation training course developed time complete involvement actors concerned within institutional framework training sessions scheduled given raft staff members partnership programme soon enable action extended entire bourgogne franche comte region hope experience acquired project may soon utilised regions elsevier masson sas rights reserved
sensor developed simultaneous measurements carbon monoxide carbon dioxide fluctuations internal combustion engine exhaust gases sensor utilizes low cost compact light emitting diodes leds emit wavelength range affordable fast response sensor measure gases broad application lead efficient fuel flexible engines regulation harmful emissions light emission leds spectrally broader spatially divergent compared lasers presented many design challenges optical design studies addressed non ideal characteristics led emissions measurements conducted using fundamental absorption bands centered respectively reference led used account scattering losses due soot window deposits etc common three measurement leds instrument validation calibration performed using laboratory flow cell bottled gas mixtures sensor able detect concentration changes small ppm ppm respectively many control monitor species infra red absorption features measured using strategy described work demonstrates proof concept wider range fast low cost sensors gas measurement process monitoring
paper proposes two phase identification approach mamdani fuzzy neural networks first phase system identification includes novel forward recursive input output clustering method structure initialization gradient descent algorithm parameter initialization main advantage proposed method fits perfectly special clustering requirement system identification coarser clustering regions identified system smoother finer clustering regions system variable nonlinear second phase system simplification includes accurate similarity analysis merging method similar fuzzy rules gradient descent algorithm parameter finalization accurate similarity analysis developed solves long standing open problem compute exact rather approximate similarity fuzzy sets rules gaussian membership functions numerical experiments based well known benchmark data sets used verify effectiveness accuracy proposed approach elsevier rights reserved
sao joao drainage basin important strategic waterbody located lagos region rio janeiro state one popular tourist regions brazil however fast economic subsequent population growth region created untreated wastes several anthropogenic activities include trace metals disposal surface waterbody study aims relate major ions trace metals behavior year sampling campaign provide information sources chemical constituents factors control concentrations three main fluvial compartments drainage basin including juturnaiba reservoir crucial role water supply lagos region chemical data reveal rainfall main factor responsible physicochemical parameters water dissolved constituent variations geological anthropogenic factors main sources water constituents assessed inorganic chemical index data corroborate great influence rainfall reveal importance anthropogenic sources chemical constituents parts juturnaiba reservoir geochemical modeling suggests hydrolysis reactions primarily responsible trace metals availability three fluvial compartments dry wet seasons followed carbonate sulfate complexation
objective evaluate relationship serum resistin levels metabolic syndrome mets chronic spontaneous urticaria csu patients methods study csu patients healthy volunteers included height weight waist circumference blood pressure measurements assesed groups fasting blood sugar serum lipid levels resistin tumor necrosis factor alpha tnf alpha levels evaluated venous blood samples metabolic syndrome mets diagnosis determined using national cholesterol education program adult treatment panel iii diagnostic criteria results mets found csu patients control subjects statistically significant difference two groups terms mets presence found mean serum resistin levels csu patients control group statistically significant difference groups terms serum resistin levels difference seen patients without diagnosis mets regarding urticaria activity score duration disease autologous serum skin test positivity serum immunoglobulin levels presence autoimmunity serum resistin tnf alpha levels conclusion increased incidence mets csu patient group found study however difference csu patients without mets regarding disorder associated parameters serum resistin tnf alpha levels
model uncertainty saturation actuators among practical challenges controller design autonomous vehicles incorporating adaptive control anti windup compensators provide convenient combination counteract challenge manuscript adaptive control dynamic anti windup compensator proposed autonomous underwater vehicle auv due industrial academic interests proposed method embedded proportional derivative integral pid controller modern technique employed cope saturation problem typical performance adaptive control system achieved absence actuator saturation performance shown degrade saturation occurred however quality adaptive controller improved combined anti windup compensator primarily six degrees freedom dof nonlinear motion equations vehicle derived proposed scheme applied nonlinear model performance modified system compared baseline controller effectiveness presented method presence actuator saturation considering uncertainties noise disturbance assessed verified simulation scenarios elsevier rights reserved
aberrant oxygen environment birth increases severity respiratory viral infections later life poorly understood mechanisms show alveolar epithelial cell aec cells aecs progenitors aec cells depleted adultmice exposed neonatal hypoxia hyperoxia airway cells expressing surfactant protein atp binding cassette subfamily member alveolar pod cells expressing keratin krt pulmonary fibrosis observed mice infected sublethal dose hkx influenza virus seen infected siblings birthed room air genetic lineage tracing studies mice exposed neonatal hypoxia hyperoxia revealed pre existing secretoglobin cells produced airway cells expressing atp binding cassette subfamily member pre existing progenitor cells produced squamous alveolar cells expressing receptor advanced glycation endproducts aquaporin alveoli devoid aecs source krt alveolar pod cells oxygendependent changes epithelial cell regeneration fibrosis could recapitulated conditionally depletingaecs mice using diphtheriaa toxin infecting influenza virus likewise airway cells expressing alveolar cells expressing krt observed human idiopathic pulmonary fibrosis findings suggest alternative progenitor lineages mobilized regenerate alveolar epithelium aecs severely injured depleted previous insults adverse oxygen environment birth lineages regenerate aecs spatially distinct compartments lung undergoing fibrosis may sufficient prevent disease
commercial sexual exploitation children csec associated child abuse neglect poverty homelessness societal causes sex trafficking participation commercial sex acts force fraud coercion occur article discusses scope csec sex trafficking necessary identification skills medical evaluations needed help patients
potential electric vehicles obtain income energy supplied commercial building together revenue accruing specific ancillary service markets evaluated work hybrid time series probabilistic simulation environment using real world data described applied analysis electricity trading vehicle grid vehicles buildings markets key parameters found electric vehicle electricity sale price battery degradation cost infrastructure costs three vehicle grid scenarios evaluated using pool vehicle trip data market pricing index data half hourly electricity demand commercial building results show provision energy wholesale electricity market additional income capacity market results greatest projected return investment producing individual vehicle net present value similar pound years vehicle supplying energy three times per week half hour day ahead market includes cost installing vehicle grid infrastructure analysis also shows net income generation strongly dependent upon battery degradation costs associated vehicle grid cycling elsevier ltd rights reserved
previous studies showing autism spectrum disorder asd children secondary effects child parents limited small sample sizes parent self report examined odds depression parents children asd compared parents children without asd using large national claims database mothers fathers children asd likely diagnosis depression parents children without asd odds depression also increased one child asd family child age study results reinforce benefits support education parents children asd
propose new method client side data caching relational databases central server distant clients data loaded client cache based queries executed central database server queries special form universal relational query majority search queries database expressed form besides form allows analyze query correctness checking lossless join property subsequent query may executed client local cache determine query result entirely contained cache compare truth spaces logical restrictions new user query results queries execution cache method may used define lacking data cache execute query server data problem data actualizations cache discussed paper however solved cataloging queries server serving triggers background mode
introduction stress management training programs increasingly adopted military field resilience empowerment primary stress prevention last several years advanced technologies virtual reality particular integrated order develop innovative effective stress training programs military personnel including soldiers pilots aircrew professionals systematic review describes experimental studies conducted recent years test effectiveness virtual reality based stress managementtraining programs developed military personnel promising state art technology potential successful new approach empowering soldiers increasing resilience stress methods provide overview application virtual reality stress management training programs developed military computer based search relevant publications performed several databases databases used search psycinfo web science web knowledge pubmed medline search string virtual reality military stresstraining stress management results studies met inclusion criteria included review discussion main observation drawn review virtual reality provide interactive stress management training decrease levels perceived stress negative affect military personnel technology appears promising tool assessing individuals resilience stress identifying impact stress physiological reactivity performance
real drawback concept electrical generator sets egs variable speed engine generator dynamics sudden load change low high analysis dynamic behavior presented paper proves disadvantageous dynamical properties egs concepts variable speed engine improved using energy storage element paper give results design directional converters energy buffer supercapacitors also demonstrates results dynamic behavior egs energy buffer
paper space variable order fractional schrodinger equation vofse studied numerically variable order fractional derivative described sense quantum riesz feller definition proposed numerical method weighted average non standard finite difference method wansfdm special attention given study stability analysis convergence proposed method finally two numerical examples provided show method reliable computationally efficient
linear quadratic control synthesis set coupled first order hyperbolic partial differential algebraic equations presented using infinite dimensional hilbert state space representation system well known operator riccati equation ore method solving algebraic equations substituting partial differential equations pdes results model consisting set pure hyperbolic pdes resulting pde system involves hyperbolic operator velocity matrix spatially varying non symmetric eigenvalues necessarily negative domain semigroup generation property operator proven shown generated semigroup exponentially stable consequently ore unique non negative solution conversion ore matrix riccati differential equation allows use numerical scheme solve control problem
modern nanotechnology produce metallic non metallic particles nanometer dimensions unique optical mechanical magnetic electrical thermal properties purpose review summarise important published articles enhancement convection heat transfer using nanoparticles dispersed ethylene glycol effects thermal properties applications paper reviews articles relevant nanoparticles suspended studies thermal properties including experimental measurement correlations reported effects nanofluid volume fraction temperature base fluid included stability nanofluid shown testing avoid agglomeration clusters many applications paper applications nanofluids different types heat exchangers cooling systems solar energies reviewed field economics nanotech reduces manufacturing costs result using low temperature process order focus future studies nanofluid applications articles field summarized
traditional korean asian medicine salvia plebeia plebeia leaves used treat inflammatory diseases including dermatitis cough asthma toothache recently plebeia leaves applied skin care promote skin lightening elasticity therefore present study investigated anti aging effects plebeia leaf methanolic extract fractions dichloromethane ethylacetate butanol results whole cell patch clamp analysis indicated methanolic extract mediated ultraviolet induced photoaging associated ion channels transient receptor potential vanilloid trpv calcium release activated calcium channel protein orai channel activity hekt cells overexpressing trpv orai stim electrophysiological analysis revealed butanol fraction inhibited capsaicin induced trpv orai currents furthermore dichloromethane hexane fractions inhibited tyrosinase activity respectively furthermore ethylacetate butanol fractions inhibited elastase activity respectively tyrosinase elastase induced photoaging associated enzymes regulate skin pigmentation wrinkle formation respectively results present study indicated plebeia leaves may novel treatment induced photoaging
neurodegenerative disorders including alzheimer disease parkinson disease huntington disease affect millions people world thus several new approaches treat brain disorders development aim present study synthesize potential neuroprotective heterocyclic compounds based pyrazolopyridine derivatives evaluate effects mpp induced neurodegeneration human neuroblastoma cell line syy cells effects compounds cell viability measured mtt assay changes apoptosis related proteins including bax bcl bcl caspase investigated western blot technique based cell viability results obtained mtt assay percentage neuroprotection induced compounds mpp induced neurotoxicity syy cells concentrations synthesized compounds moreover downregulation pro apoptotic proteins including bax caspase found following novel synthesized compounds treatments effects observed dose dependent manner results provide evidence heterocyclic compounds based pyrazolopyridine derivatives may role dopaminergic neuroprotection via antiapoptotic pathways elsevier masson sas rights reserved
energy efficiency pumping affected motor efficiency paper studies applicability common electric motor types industrial pumping system comparing motor efficiency characteristics analysing motor efficiency sizing affect resulting pumping system energy consumption standard load profile objective paper provide guidance motor sizing energy efficient alternative selected given pumping system
aims provide new insights socio demographic characteristics people frequently attend accident emergency departments alcohol related reasons explore findings reference stereotyping prejudice methods semi structured qualitative interviews individuals males females aged years recruited six departments across london united kingdom participants attended times within last year times last three months alcohol related condition detailed data relating participants socio demographic characteristics systematically coded analysed findings participants reported many years heavy drinking high levels mental physical ill health unemployment dependence state benefits housing problems social isolation frequency attendances varied greatly participant patterns drinking substance use diverse nature extent self reported health social problems wide ranging conclusions findings suggest people regularly attend alcohol related reasons collectively experience multiple complex needs individually diverse patterns drinking problems flexible person centred systems could help support patient population whilst avoidance terminology overstates group traits help minimise stigma
background musculoskeletal involvement extremely common patients systemic lupus erythematosus sle continuing research initiated patients inflammatory arthritis recent studies shown potential role musculoskeletal ultrasound msus evaluation clinical subclinical lupus synovitis inflammatory process sle traditionally considered localized synovial tissue areas enthesis included among possible targets disease patients methods entheses included glasgow ultrasound enthesitis scoring system scanned cohort sle patients serving disease controls msus study aimed assessing enthesitis patients psoriatic arthritis describe detail four cases unexpected unequivocal expressions msus enthesitis according omeract definition three four patients predisposing factors enthesopathy case treated variable dose prednisone regimen results four cases msus examination revealed relevant grey scale power doppler abnormalities entheseal level commonly distal insertion patellar tendon signs clinical enthesitis detected one patient conclusions case series shows first time presence clearly evident msus findings indicative enthesitis four sle patients raising hypothesis enthesis could missing target clinical evaluation sle patients case series justifies investigations better evaluation prevalence characteristics clinical relevance entheseal involvement sle
among methods knowledge discovery rough set proposed pawlak one important theories one key concept rough set reduction proved hard problem order improve effectiveness reduction quick algorithm information reduction rule acquisition based distributed computing put forward algorithm attribute value tree decision table firstly created structure parallel computing distributed reduction proposed taking advantage distributed feature cloud method makes use relative independent characteristic attribute value trees improve effectiveness reduction fit deal big data distributed cloud environment
without power political authority planning theorists advice planners politically astute little help politically astute planners could little face political pressure context logical advice planners would join politics acquire political authority need materialize plans article case studies united states brazil nepal shows planners joined politics able accomplish difficult planning tasks towns suggests planners take elected position possible
backgrounds aims effect cigarette smoking ambivalent since smoking improves ulcerative colitis worsens crohn disease although clinical relationship inflammatory bowel disease ibd tobacco well established experimental works investigated effect smoking colonic barrier homeostasis focusing xenobiotic detoxification genes methods comprehensive integrated comparative analysis global xenobiotic detoxification capacity normal colonic mucosa healthy smokers non smokers versus non affected colonic mucosa patients performed quantitative real time polymerase chain reaction qrt pcr detoxification gene expression profile analysed patients smoking patients biopsies non smoking patients cultured cigarette smoke extract results detoxification genes investigated dysregulated patients comparison healthy controls patients expression genes inversed biopsies smoking patients remission colonic explants patients exposed cigarette smoke extract devised network based data analysis approach differentially assessing changes genetic interactions allowing identification unexpected regulatory detoxification genes may play major role beneficial effect smoking conclusions non inflamed colonic mucosa characterised specifically altered detoxification gene network partially restored tobacco mucosal signatures could useful developing new therapeutic strategies biomarkers drug response
order obtain precise measurements position agents located considerable distance using sensor system based position sensitive detectors psd necessary analyze mitigate factors generate substantial errors system response sources error divided electronic geometric factors former stem nature construction psd well performance tolerances electronic response system latter related sensor optical system focus solely electrical effects since study analysis correction prerequisite subsequently addressing geometric errors simple calibration method proposed considers psd response component tolerances temperature variations signal frequency used signal noise ratio snr suboptimal operational amplifier parameters analog digital converter adc quantitation snrq etc following analysis effects calibration sensor possible correct errors thus rendering effects negligible reported results section
afferent input delta fibres innervating urinary bladder processed differently brain different roles signaling bladder sensation delta fibres signal bladder filling activate spino bulbo spinal loop relays midbrain periaqueductal grey pag pontine micturition centre pmc excitability circuitry regulated tonic gabaergic inhibitory processes humans socialised animals micturition normally volitional control influenced host psychosocial factors higher nervous decision making social context probably resides frontal cortical areas act central control switch micturition exposure psychosocial stress profoundly disruptive influence process lead maladaptive changes bladder sleeping voiding reflex threshold appears reset higher level promote urinary continence physiological conditions fibre bladder afferents normally silent activated inflammatory bladder states intense distending pressure following prolonged stimulation visceral nociceptors sensitise leading lowered threshold heightened sensitivity addition sensitization may occur within central pain processing circuitry outlasts original nociceptive insult visceral nociception may also influenced genetic environmental influences period chronic stress produce increased sensitivity visceral pain lasts months adverse early life events produce even longer lasting epigenetic changes increase individual susceptibility developing visceral pain states adulthood elsevier rights reserved
personalized prosthetic joint replacements important applications cases complex bone joint conditions shape size shelf components may adequate objective study design test fabricate personalized printed prosthesis patient requiring total joint replacement surgery temporomandibular joint tmj new melbourne prosthetic tmj design featured condylar component sized specifically patient fixation screw positions avoid potential intra operative damage mandibular nerve melbourne prosthetic tmj developed year old female recipient end stage osteoarthritis tmj load response prosthesis chewing maximum force bite quantified using personalized musculoskeletal model patient masticatory system developed using medical images simulations repeated implantation biomet microfixation prosthetic tmj established stock device maximum condylar stresses screw stress mandibular stress screw bone interface lower melbourne prosthetic tmj mpa mpa mpa respectively biomet microfixation device mpa mpa mpa respectively maximum force bite similar trends also observed chewing bite trialing surgical placement evaluating prosthetic tmj stability using cadaveric specimens prosthesis fabricated using printing sterilized implanted female recipient six months post operatively prosthesis recipient normal jaw opening distance complications identified new design features immediate load response melbourne prosthetic tmj suggests may provide improved clinical biomechanical joint function compared commonly used stock device reduce risk intra operative nerve damage placement framework presented may useful designing testing customized devices treatment debilitating bone joint conditions
bilateral adrenal hemorrhage bah rare complication typically seen critically ill patients lead acute adrenal insufficiency death unless recognized promptly treated appropriately describe case year old man polycythemia vera found unresponsive fever hypotension tachycardia hypoglycemia electrocardiogram showed elevation elevated troponin hemoglobin prothrombin time partial thromboplastin time required aggressive ventilator vasopressor support despite primary coronary intervention remained hypotensive random cortisol level low received stress dose hydrocortisone immediate hemodynamic stability bah highly suspected confirmed non contrast abdominal computed tomography prompt recognition timely initiated treatment remain crucial impact mortality associated acute adrenal insufficiency
ponatinib iclusig ariad pharmaceuticals incyte third generation structure guided tyrosine kinase inhibitor approved treatment philadelphia chromosome positive leukaemias resistant intolerant inhibitors clinical use ponatinib complicated possible development cardiovascular events primarily hypertension arterial venous thrombotic events food drug administration european medicine agency recommend cardiovascular profile patients candidate ponatinib carefully evaluated patients deemed carry high risk cardiovascular events life saving therapeutic options considered alternative options available treatment ponatinib indicated requires haematologists cardiologists collaborate identify modalities surveillance risk mitigation best interest patient article reports expert opinion provided panel italian haematologists cardiologists clinical pharmacologists summarises suggestions may help improve therapeutic index ponatinib primarily settings chronic phase chronic myeloid leukaemia
accurately monitoring global vegetation dynamics modern remote sensing critical understanding functions processes biosphere interactions planetary climate moderate resolution imaging spectroradiometer modis vegetation index product primary data source purpose date modis team released several versions products widely used global change studies practical applications study examined global vegetation activity comparing recent modis collection vis collection vis including normalized difference vegetation index ndvi enhanced vegetation index evi terra aqua satellites found substantial differences global vegetation trends betweenterra vis especially evi global vegetation showed remarkable greening trend annual evi terra year contrast decreasing evi trend terra year spatially large portions browning areas tropical regions identified terra vis evident terra vis contrast widespread greening areas terra vis consistent aqua vis gimmsg ndvi finding greening earth supports recent studies suggesting enhanced land carbon sink study suggests vegetation browning trends detected modis terra vis likely caused sensor degradation particularly period therefore previous studies temporal vegetation trends based solely terra vis may need reevaluated new analysis offers updated understanding global vegetation dynamics past years contributes accurately understanding role vegetation played earth biogeochemical climatic systems elsevier inc rights reserved
software development highly dependent human efforts collaborations immensely affected emotions paper presents quantitative empirical study emotional variations different types development activities bug fixing tasks development periods days times projects different sizes involving teams variant sizes study also includes depth investigation emotions impacts software artifacts commit messages exploration scopes exploiting emotional variations software engineering activities work based careful analyses emotions thousand commit comments across open source projects findings work add understanding role emotions software development expose scopes exploitation emotional awareness improved task assignments collaborations
maternal authoritarian style related development physical aggression childhood later future social problems however many studies detected individual family factors may buffer maternal effect work examines whether daycare center attendance may moderate relationships mother authoritarian style physical aggression study sample girls kindergarten children spain parents asked complete two questionnaires focused individual family characteristics parenting styles age children physical aggression assessed direct observation playtime aggression scores obtained peer rated questionnaire least squared multiple regression performed controlling children level physical aggression child sex siblings positive contribution maternal authoritarian style physical aggression detected daycare center attendance appears attenuate effect mother authoritarian style physical aggression boys
use simulation tools three dimensional computer aided design currently widespread process engineering machine design manufacturing tools dimensional control models common method job design workplace design essential data product process resources needed manufacture human factor key issue among resources obliges make working environment major study order ensure operators perform tasks safety way without injury damages way use digital human model first element denominated digital manufacturing excellent opportunity integrate product process design elements real concurrent engineering allows analyze important variables ergonomics time estimation ergonomics point view possible potential injuries musculoskeletal system could result consequence job tasks development generated great interest manufacturing engineering paper presents addition extension annexe ergonomic analysis methods risks prevention currently one used tools sectors aeronautics automotive first time satisfactorily implemented ocra check list method design simulation environment application evaluating simulation tool ability capacity tasks time prediction application together evaluator active participation permits make correct risks analysis musculoskeletal injuries due repetitive work well tasks time development estimation
objectivesdiagnosis ubiquitous psychiatry whilst bring benefits adverse effects labelling may also possible study aimed evaluate experimentally whether clinicians judgements patient panic disorder influenced inappropriately suggested diagnosis comorbid borderline personality disorder bpd designan experimental design used evaluate clinician judgements nature information given varied imply bpd comorbidity methodstwo hundred sixty five clinicians watched video recorded assessment woman describing experience uncomplicated panic disorder rated present problems likely prognosis prior watching video recording participants randomly allocated one three conditions written information including following personal details general background addition behavioural description consistent bpd addition label past bpd diagnosis resultsthe bpd label associated negative ratings woman problems prognosis information alone behavioural description bpd symptoms conclusionsregardless potential actuarial value diagnoses concluded clinicians overly influenced past diagnostic labels context apparent current comorbid problem although biases appear less likely description relevant behaviours used instead thus label rather behaviour denotes may stigmatizing mental health professionals practitioner points diagnostic labels inappropriately negative effect clinicians judgements treatment variables engagement response also risk issues interpersonal effectiveness diagnostic labels greater effect clinicians judgements behavioural description clinical presentation clinicians therefore cautious use diagnostic labels describe patients ensure still valid also mindful influence labels clinical judgements constantly seek challenge behavioural descriptions difficulties less likely result negative judgements predictions
observers frequently form impressions people based complex conflicting information rather objective impressions often biased observers motives instance observers often downplay negative information learn ingroup members characterize neural systems associated biased impression formation participants learned positive negative information ingroup outgroup social targets following information participants worsened impressions outgroup ingroup targets tendency associated failure engage neural structures including lateral prefrontal cortex dorsal anterior cingulate cortex temporoparietal junction insula precuneus processing negative information ingroup outgroup targets extent participants engaged regions learning negative information ingroup members exhibited less ingroup bias impressions data consistent model effortless bias perceivers fail process goal inconsistent information order maintain desired conclusions
construction stage building lifecycle dynamic stage several activities job site involve materials workers moving handling equipment construction activities sustainable time safe workers although many countries construction safety health regulations well green building rating systems including construction integrated separate procedures regulating institutions research aims review available literature related construction sustainability construction worker safety health assist exploring integration worker safety health sustainable construction practices research findings demonstrate need significance integrating worker safety health sustainable construction practices realize cost efficiencies
cryptococcosis invasive fungal infection common immuno compromised patients year old woman ewing sarcoma right proximal humerus treated resection chemotherapy computed tomography detected small nodule right upper pulmonary lobe completion chemotherapy presumptive diagnosis pulmonary metastasis underwent resection evaluation resected specimen revealed pulmonary cryptococcosis patient treated oral fluconazole weeks extensive chemotherapy high grade sarcoma possible risk factor pulmonary cryptococcosis differential diagnosis nodular pulmonary lesion develops patient undergoing treatment high grade sarcoma important
many scientific studies measure different types high dimensional signals images subject producing multivariate functional data functional measurements carry different types information scientific process joint analysis integrates information across may provide new insights underlying mechanism phenomenon study motivated fluorescence spectroscopy data cervical pre cancer study multivariate functional response regression model proposed treats multivariate functional observations responses common set covariates predictors novel modeling framework simultaneously accounts correlations functional variables potential multi level structures data induced experimental design model fitted performing two stage linear transformation basis expansion functional variable followed principal component analysis concatenated basis coefficients transformation effectively reduces intra inter function correlations facilitates fast convenient calculation fully bayesian approach adopted sample model parameters transformed space posterior inference performed inverse transforming regression coefficients back original data domain proposed approach produces functional tests flag local regions functional effects controlling overall experiment wise error rate false discovery rate also enables functional discriminant analysis posterior predictive calculation analysis fluorescence spectroscopy data reveals local regions differential expressions across pre cancer normal samples regions may serve biomarkers prognosis disease assessment elsevier rights reserved
background aims smartphones ubiquitous smartphones increased popularity researchers realized people becoming dependent smartphones purpose provide better understanding factors related problematic smartphone use pspu methods participants undergraduates males females whose ages ranged mean age years participants completed questionnaires assess gender ethnicity year college father education level mother education level family income age family history alcoholism pspu family tree questionnaire assessed family history alcoholism mobile phone problem use scale mppus adapted cell phone addiction test acpat used determine degree pspu whereas mppus measures tolerance escape problems withdrawal craving negative life consequences acpat measures preoccupation salience excessive use neglecting work anticipation lack control neglecting social life results family history alcoholism father education level together explained variance mppus scores variance acpat scores inclusion mother education level ethnicity family income age year college gender significantly increase proportion variance explained either mppus acpat scores discussion conclusions family history alcoholism father education level good predictors pspu variance pspu scale scores explained future studies aim explain variance
background multi site prescription opioid addiction treatment study poats conducted national drug abuse treatment clinical trials network largest clinical trial yet conducted patients dependent upon prescription opioids addition main trial results study yielded numerous secondary analyses included year follow study first kind population paper reviews key findings poats follow study methods paper summarizes poats design main outcomes predictors outcome subgroup analyses predictive power early treatment response long term follow study results poats examined combinations buprenorphine naloxone varying duration counseling varying intensity primary outcome analysis showed overall benefit adding drug counseling buprenorphine naloxone weekly medical management patients achieved successful outcome abstinence near abstinence opioids week taper week follow comparison patients achieved success subsequently stabilized buprenorphine naloxone long term follow results encouraging higher abstinence rates main trial patients receiving opioid agonist treatment time follow likely better outcomes though sizeable number patients succeeded without agonist treatment patients initiated risky use patterns including heroin use drug injection limitation long term follow study low follow rate conclusions poats first large scale study treatment prescription opioid dependence findings influence treatment guidelines future studies author published elsevier ireland ltd
bioactive antioxidant peptides attracting attention food manufacturers potential transform food functional food able prevent variety chronic diseases associated oxidative stress present study proteins extracted different vegetable sources kamut khorasan wheat emmer lupine pea hydrolyzed commercial enzymes lactobacillus spp strains hydrolysates separated size exclusion chromatography purified fractions analyzed antioxidant activity peptides fractions highest activity identified nanolc esi qtof thirteen peptides selected synthesis basis sequence four peptides vlppqqqy tvtsldlpvlrw vtsldlpvlrw fvpy found able scavenge superoxide anion hydroxyl radicals organic nitro radicals abts dpph inhibit lipid peroxidation impact work targeted add hydrolysed vegetable proteins reformulated functional food produce health promoting ingredients nutraceuticals elsevier ltd rights reserved
background suture button repair widely accepted surgical treatment acute isolated ankle syndesmosis injuries knowledge midterm results previously reported purpose evaluate clinical qualitative quantitative radiological midterm outcomes suture button repair acute isolated ankle syndesmosis injuries study design retrospective case series level evidence methods clinical outcomes measured using foot ankle disability index fadi american orthopaedic foot ankle society aofas score three tesla magnetic resonance imaging mri performed bilaterally ankle besides morphological sequences evaluation syndesmosis degenerative changes ankle using ankle osteoarthritis scoring system aoss protocol included coronal dimensional multislice multiecho sequence quantitative cartilage weighted mapping spearman correlations paired tests used statistical analysis results retrospective study included consecutive patients mean age years acute isolated syndesmosis injuries treated suture button system january june mean follow years postoperatively median fadi score range median aofas score range seventeen patients reported reached preinjury level sports activities mris patients obtained showed intact anterior posterior syndesmotic ligaments however patients previously injured syndesmotic ligament thickened compared uninjured ankle average width anterior posterior syndesmosis significantly different ipsilateral contralateral ankles median aoss score range ipsilateral ankle range contralateral ankle values articular cartilage significantly differ involved uninjured ankle five patients needed hardware removal due persistent skin irritation patient suffered reinstability ankle resulting revision surgery years index surgery conclusion suture button fixation excellent treatment acute isolated syndesmosis injuries resulting stable ankles without early advanced osteoarthritic changes midterm follow
manufacturing engineering optimization often one encounters scenarios multi objective objectives portray different aspects problem thus crucial engineer access multiple solution choices selecting best solution work novel approach merges meta heuristic algorithms normal boundary intersection nbi method introduced method used generate optimal solution options green sand mould system problem nbi based method provides near uniform spread pareto frontier multiple solutions gradual trade offs objectives obtained comparative studies carried algorithms developed used work previous work analysis performance well quality solutions produced algorithms presented society manufacturing engineers published elsevier ltd rights reserved
develop trust management model efficiently control manage nodes important issue scope social network security paper trust management model based cloud model proposed cloud model uses specific computation operator achieve transformation qualitative concepts quantitative computation additionally also used effectively express fuzziness randomness relationship subjective trust node trust divided reputation trust transaction trust addition evaluation methods designed respectively firstly two dimension trust cloud evaluation model designed based node comprehensive trading experience determine reputation trust expected value reflects average trust status nodes entropy hyper entropy used describe uncertainty trust secondly calculation methods proposed direct transaction trust recommendation transaction trust involve comprehensively computation transaction trust node choosing strategies designed node trade based trust cloud finally results simulation experiment network file sharing experimental platform directly reflect objectivity accuracy robustness proposed model could also effectively identify malicious unreliable service nodes system addition used promote service reliability nodes high credibility stability whole network improved
study used subjects post test design test effects video game realism doom doom control condition attention retention aggressive outcomes overall played doom perceived significantly realistic played doom thus providing validity manipulation next played doom significantly attentive experienced presence played doom furthermore playing either doom game resulted aggression playing game physically aggressive intentions higher among played doom compared played doom lastly tested possible interaction realism attention retention subfunctions production found compared players experienced greater identification among playing doom higher verbal aggression physical aggression played doom experienced attention greater identification higher aggression scores conditions elsevier ltd rights reserved
purpose purpose paper provide new approach involving guidelines supporting techniques guarantees needed space appropriate product maintenance design methodology approach approach based two major areas field survey understand maintainability parameter applied converge theory practice systematic space claim method using computer aided design cad systems assure proper maintenance procedures design stages findings case studies truck industry conducted following proposed approach contrast savings achieved using proper space claim aftermarket needs unsuitable level participation maintenance personnel design development research limitations implications approach highly dependent maintenance experts suitable skills cad systems practical implications products developed according approach envisaged result following aspects lower repair time better maintenance procedures key components easier preventive maintenance less need special tools ergonomic design better communication design service engineers simplicity less complex training social implications research maintainability provide new information apply parameter product development process pdp design teams better understand address relevant issue proposed method introduced pdp major multinational automotive company originality value new process presented considering protection needed spaces maintenance procedures throughout pdp diverging studies propose analysis addressing maintainability singular point time product development one case study presented savings achieved applying space claim approach
paper introduce software asset analyzer saa system monitors detects potentially vulnerable software asset modifications end devices used guide patch management software patching complex failure prone process enterprise networks requires triage accurate inventories software applications operating systems improve patching efficiency significant concern security analysts generating asset baselines saa identifies reports abnormal deviations individual end devices allows security analysts identify vulnerable devices enforce security patching system also suited detecting vulnerable software installs remediation process verification saa low cost efficient method yields accurate complete inventories assets end devices reducing potential loss new vulnerabilities
atopic dermatitis paradigmatic chronic inflammatory skin disease characterized complex pathophysiology wide spectrum clinical phenotype despite high degree heterogeneity adis still considered single disease usually treated according one size fits approach thus tailored prevention therapeutic strategies still lacking disciplines oncology rheumatology approach differentiated way dissect stratify complex clinical phenotype homogeneous subgroups based endophenotype panel biomarkers aim refine management condition entering era personalized medicine systems biology approach merging numerous clinical phenotypes robust relevant validated biomarkers needed best exploit potential significance future molecular taxonomy approach allow optimized prevention treatment available drugs also hopefully help assign newly developed medicinal products patients best benefit risk ratio
last decades witnessed rapid development green buildings china especially office sector life cycle assessment lca approach potential weigh benefits costs associated green building developments essentially lca method evaluates costs benefits across building life cycle system approach study green office building beijing china analyzed life cycle assessment quantify energy use evaluate environmental impacts life cycle stage environmental impacts reduced using gas fired electricity generation increasing summer indoor temperature degrees switching office equipment lighting lunchtime respectively similarly reusing selected materials building finally demolished three major adverse environmental impacts human health ecosystem quality resource depletion reduced respectively sensitivity analysis shows electricity conservation effective materials efficiency terms reduction environmental impacts findings useful inform decision makers different stages green building life cycle
objectives known whether psychosocial chronic pain treatments produce benefits unique mechanisms specified theory fundamental gaining accurate understanding issue first determine whether widely used process measures assess unique constructs predict unique variance pain outcomes study examined associations pain catastrophizing scale pcs five facet mindfulness questionnaire ffmq chronic pain acceptance questionnaire cpaq determined unique contributions prediction pain intensity pain interference depression methods cross sectional study conducted undergraduate students reporting chronic intermittent pain correlations regression models multiple mediation models performed relevant covariates included results pcs ffmq scales cpaq correlated mostly expected directions highly indicate redundancy pcs significantly predicted pain intensity interference depression ffmq observing describing scales predicted pain intensity nonreactivity nonjudging significantly predicted interference depression respectively cpaq significant predictor regression models pcs comparatively stronger mediator ffmq scales intensity interference intensity depression mediation models discussion findings indicate pain catastrophizing mindfulness pain acceptance related unique constructs pcs select ffmq scales uniquely associated criterion measures however pcs emerged robust process highlighting importance targeting cognitive domain streamlining pain treatments optimize outcome
effective emotionally nurturing parenting practices constitute salient protective factors lives children youth although social workers influenced important ways scholarship associated development dissemination culturally relevant evidence based parenting interventions underserved populations low income ethnic minorities continue lack access culturally relevant efficacious parenting interventions united states due widespread mental health disparities addressing gap service delivery necessary particularly populations exposed historical oppression intense contextual adversity increased risk engaging harsh parenting practices purpose paper reflect process change documented group underserved latino immigrant parents exposed culturally adapted evidence based parenting intervention emphasis describing process change leading improved outcomes relevant clinical social workers engaged direct delivery preventative clinical parenting interventions thus manuscript focus issues engagement retention parents important consideration importance integrating evidence based knowledge cultural relevance key principles social work practice
alternative morphotypes reported less frequently females males exception rule gradient phenotypical masculinization reported female mammals feminized masculinized females represent two opposite ends along gradient phenotypical differences originate prenatal development consequence maternal effects feminized masculinized females differ several traits including morphological physiological behavioural reproductive traits differences previously reported reproductive traits feminized masculinized females come mostly mechanistic studies performed laboratory necessarily social species result unclear extent reported differences female alternative morphotypes materialize wild natural populations quantified effect female alternative morphotype female reproductive traits natural population octodon degus highly social rodent assessed female alternative morphotype continuous gradient anogenital distance thus feminized females close short end anogenital distance masculinized females close long end gradient also tested hypothesis social environment interacts female morphotype influence female reproductive traits female degus body weight affected litter size heavier females weaned offspring masculinized females delivered male biased litters weaned heavier offspring lastly masculinized females gave birth later breeding season compared feminized females contrary previous claims findings support masculinized females less fertile feminized females moreover masculinized females produced heavier potentially higher quality offspring compared feminized females
permutation polynomials finite fields play important roles finite fields theory also wide applications many areas science engineering coding theory cryptography combinatorial design communication theory permutation binomials permutation trinomials attract people interest due simple algebraic forms additional extraordinary properties paper find new result permutation binomials construct several new classes permutation trinomials generalizations known ones published elsevier inc
aimsto determine minimizing number onabotulinumtoxina btx injection sites one three locations provides similar clinical efficacy duration effect compared established technique treating patients neurogenic ndo idiopathic detrusor overactivity ido methodsprospective data collected btx naive patients ndo ido intolerant refractory oral medications patients treated btx via one three injection sites patients completed international consultation incontinence questionnaire short form iciq prior treatment primary endpoint defined iciq score improvement points secondary endpoints included subjective success complete continence quality life score post void residual pvr duration effect adverse events resultsfourty five patients ido ndo included iciq score improvement points achieved ido ndo subjective success rate ido ndo ndo patients attained complete continence pvr increased mean ido ndo groups hematuria occurred symptomatic urinary tract infection occurred systemic btx adverse events occurred mean duration effect weeks conclusionsour technique administering btx via one three intradetrusor injection sites similar clinical efficacy rates adverse events compared established technique treating patients ido ndo neurourol urodynam wiley periodicals inc
based pebb concept multi phase bidirectional converter proposed signal flow graph sfg models ccm dcm mode positive power flow reverse power flow deduced dual closed loop controller designed improve system stability dynamic performance current voltage ripples analyzed thoroughly design coupled inductors given finally prototype kva directional converter developed converter system high output voltage high current possible low cost experimental results provided confirm analysis control concept
present study examined authoritative parenting associations parenting sense competence social support chinese mothers children intellectual disability mothers typically developing children one hundred sixty seven mothers children intellectual disability mean age years mothers typically developing children mean age years participated survey mothers children intellectual disability reported similar levels parental warmth less use reasoning autonomy support compared mothers typically developing children parenting efficacy contributed uniquely three dimensions authoritative parenting mothers children intellectual disability comparison parenting efficacy contribute use reasoning autonomy support mothers typically developing children social support made unique small contribution parental warmth parental reasoning autonomy support mothers children intellectual disability mothers typically developing children social support associated parental warmth autonomy support study suggests child disability status related maternal authoritative parenting additionally parenting efficacy plays critical role predicting authoritative parenting chinese mothers children intellectual disability mothers typically developing children
paper describes development implementation experimental investigation hybrid model predictive control hmpc strategy control solar assisted heating ventilation air conditioning hvac systems site thermal energy generation storage comprehensive approach thermal energy management residential building presented optimise scheduling available thermal energy resources meet comfort objective system hybrid nature continuous variables discrete logic driven operating modes proposed control strategy organized two hierarchical levels high level hmpc controller prediction horizon control step used select operating mode hvac system low level operating mode optimised using rolling prediction horizon min control step proposed control strategy practically implemented building management control system bmcs net zero energy solar decathlon house house features sophisticated hvac system comprising air based photovoltaic thermal pvt collector phase change material pcm thermal storage integrated air handling unit ahu ducted reverse cycle heat pump system simulation experimental results demonstrated high performance achievable using hmpc approach optimising complex multimode hvac systems residential buildings illustrating efficient selection appropriate operating modes optimally manage thermal energy house elsevier ltd rights reserved
systematic review conducted using samueli institute rapid evidence assessment literature real process determine evidence base melatonin agent optimize sleep improve sleep quality generalize results military civilian healthy active adult population multiple databases searched yielding randomized controlled trials rcts meeting review inclusion criteria assessed methodological quality well melatonin effectiveness majority included studies high quality overall according grading recommendations assessment development evaluation grade methodology weak recommendations made preventing phase shifts jet lag improving insomnia healthy volunteers individuals history insomnia initiating sleep improving sleep efficacy based literature date recommendations use shift workers improve hormonal phase shift changes healthy people made time larger longer duration rcts utilizing well characterized products needed warrant melatonin recommendations young healthy adults
electrical mechanical design process traction motor hybrid bus application studied usually design process electric machine calls close cooperation various engineering disciplines compromises may required satisfy boundary conditions electrical thermal mechanical performances mechanical point view stress values safety factors reasonable level construction lifetime predicted fatigue analysis vehicle application motor capable generating high torque accelerating normal operation losses machine low able cool machine minimization load iron losses becomes important electrical design requirement traction motor generator mechanically connected internal combustion engine operating source torque manufacturing costs motor also taken account paper
investigated effect aminopyridine experimental autoimmune neuritis ean using treated group administered diet control group per group electrophysiological pathological assessment performed sciatic nerve ean clinical scores significantly lower treated group control group motor conductance velocity two weeks post immunization significantly higher treated group finally lead pathological changes thus might potential therapeutic agent demyelinating neuropathy elsevier rights reserved
context software defect prediction sdp important task software engineering along estimating number defects remaining software systems discovering defect associations classifying defect proneness software modules plays important role software defect prediction several machine learning methods applied handle defect proneness software modules classification problem type yes decision important drawback decision making process precise may lead misclassifications best knowledge existing approaches rely fully automated module classification provide way incorporate extra knowledge classification process knowledge helpful avoiding misclassifications cases system modules classified reliable way objective seek develop sdp method incorporates reject option classifier improve reliability decision making process makes possible postpone final decision related rejected modules expert analysis even another classifier using extra domain knowledge method develop sdp method called rejoelm variant irejoelm methods built upon weighted extreme learning machine elm reject option makes possible postpone final decision non classified modules rejected ones another moment rejoelm aims maximize accuracy rejection rate irejoelm maximizes measure hence irejoelm becomes alternative classification reject option imbalanced datasets results rejoem irejoelm tested five datasets source code metrics extracted real world open source software projects results indicate rejoelm accuracy several rejection rates comparable state art classifiers reject option although irejoelm shows lower accuracies several rejection rates clearly outperforms methods measure used performance metric conclusion concluded rejoelm valid alternative classification reject option problems classes nearly equally represented hand irejoelm shown best alternative classification reject option imbalanced datasets since sdp problems usually characterized imbalanced learning problems use irejoelm recommended elsevier rights reserved
article describes principles developing risk category labels criterion referenced prediction measures demonstrates utility creating new risk categories static static sexual offender risk assessment tools currently risk assessments corrections forensic mental health typically summarized words low moderate high although risk labels strong influence decision makers interpreted differently across settings even among trained professionals current article provides framework standardizing risk communication matching information contained risk tools broadly applicable classification riskiness independent particular offender risk scale found new common static risk categories increase concordance risk classification also allow evaluators make inferences offenders category regardless instrument used assign category membership generally argue risk categories linked decisions hand risk communication improved grounding risk categories evidence based definitions
paper presents comprehensive sensitivity analysis typical prh public rental housing development hong kong based combined building energy daylight afn airflow network simulation generic building model constructed proposed mixed mode ventilation control strategy fulfill thermal comfort requirement local green building guidance numerical modeling results used conduct local global sensitivity analyses determine relative importance major passive design parameters comprehensively cover design aspects building layout envelop thermophysics building geometry infiltration air tightness calculated global local sensitivity indices cooling energy prove window solar heat gain coefficient window ground ratio external obstruction overhang projection fraction four influential passive design factors similar results also obtained lighting energy specified output sensitivity analysis optimized building model derived sensitivity analysis anticipated achieve energy saving compared baseline model stipulated local building regulation believed sensitivity analysis useful identifying crucial design parameters facilitate optimization building performance early architectural design stages elsevier ltd rights reserved
often reported premature failures expansion joints long span steel bridges call better understanding performance service conditions paper presents long term monitoring analysis displacements expansion joints emphasis influence viscous dampers installed mitigate seismic responses bridges data three long span steel bridges chinathe sutong bridge runyang suspension bridge jiangyin bridgeare compared decomposition displacement signals various frequency bands reveals temperature induced movements contribute small portion total cumulative displacements small rapid movements caused vehicle wind loads cumulative displacements long span steel bridges may far exceed caused temperature changes according monitoring data existence viscous dampers may reduce vehicle wind induced displacements significant influence temperature induced movements finite element analyses conducted validate influence viscous dampers displacements expansion joints american society civil engineers
paper examines income induced environmental policy differences damage heterogeneity interact determine comparative advantage polluting activity non cooperative framework north south regulate two types pollution local pollution air water pollution global pollution greenhouse gas emissions induces heterogeneous damages consumers find north south comparative advantage dirty sector whatever region comparative advantage worldwide level global pollution either increase decrease trade local global emissions evolve symmetrically region trade even though pollution regulations may asymmetric
questioning kamstra kramer levi finding economically statistically significant seasonal affective disorder sad effect kelly meschke make errors commission omission misrepresent empirical results claiming sad effect arises due mechanically induced effect non existent labeling sad effect turn year effect fact models separately control turn year effects ignoring coefficient estimate patterns strongly support sad effect analysis data shows even using low power statistical tests significant international evidence supporting sad effect employing modern panel time series statistical methods strengthens case dramatically additionally kelly meschke represent finance psychology medical literatures misleading ways describing findings opposite reported researchers choosing selective quotes could easily lead readers distorted understanding findings elsevier rights reserved
bone rigid yet dynamic organ dynamism mediated delicate balance osteoclastic bone resorption osteoblastic bone formation however excessive activation osteoclasts responsible many bone diseases osteoporosis paget disease tumor bone metastasis agents could inhibit osteoclast formation function regarded promising alternatives treat osteoclast related diseases recently traditional chinese medicine attracted attention multiple activities bone metabolism among gastrodin reported anti osteoporosis agent reduces reactive oxygen species however direct action gastrodin osteoclast differentiation bone resorption underlying molecular mechanism remain unknown study investigated effects gastrodin receptor activator kappa ligand rankl activated osteoclasts formation bone resorption results showed gastrodin retarded rankl induced osteoclast differentiation efficiently downregulating transcriptional translational expression nuclear factor activated cells nfatc major factor rankl mediated osteoclastogenesis meanwhile gastrodin prevented osteoclast maturation migration inhibiting gene expression dendrocyte expressed seven transmembrane protein stamp osteoclastic specific gene controls cells fusion movement gastrodin prevented rankl induced osteoclastic bone erosion vitro addition gastrodin also stimulated bone mesenchymal stem cell bmsc spreading osseointegration titanium plate summary gastrodin could prevent osteoclasts formation bone resorption via blockage nfatcl activity stimulate osseointegration vitro gastrodin could developed potent phytochemical candidate treat osteolytic diseases published elsevier inc
dispersion corrected density functional theory dft used investigate mechanism mesoporous pulp waste mpw polyaniline pani adsorptive removal methyl orange dye aqueous solutions results absolutely reliable sufficiently accurate method although big systems studied demonstrated hydrogen bond van der waals interactions play significant role adsorption mpw pani adsorption mpw hydrogen bond van der waals interactions weakened state contrast hydrogen bond van der waals interactions pani enhanced state thermodynamic parameters enthalpy free energy change reveal adsorption mpw pani spontaneous exothermic adsorption mpw less favorable state adsorption pani favorable state therefore photoexcitation controlled adsorption mpw applied adsorption pani
although determination university students attitudes towards computer programming significant issue issue rarely studied purpose study develop attitude scale assessing university students attitudes towards computer programming first phase scale administered university students explanatory factor analysis yielded three dimensions affection cognition behavior second phase final version item scale administered university students results confirmatory factor analysis provided evidence factorial structure scale cronbach alpha coefficients ranged psychometric properties computer programming attitude scale cpas suggest valid reliable instrument measuring university students attitudes towards computer programming wiley periodicals inc
introduction recent research scientists begun suspect birth control pill use could interfere key mechanisms play role women choose sexual partner many studies shown women particularly fertile days menstrual cycle look specific physical psychological behavioral characteristics indicative genetic quality short term partner aims analysis psychometric properties partner masculinity index pmi scale scale built assess degree masculinity hypothetical short term partners methods total female italian volunteers central italy years old range years completed study psychometric properties pmi evaluated main outcome measures administered following self report questionnaires pmi minnesota multiphasic personality inventory masculinity femininity scale iii demographic questionnaire results exploratory confirmatory factor analysis showed four factor structure pmi internal consistency measure evaluated cronbach alpha satisfactory factorial anova results showed group nonpill users obtained higher scores pmi scale group pill users considering fertile phase cycle conclusions evolutionary point view changes preference indicators genetic quality sexual partner considered functional adaptive pill use may implications current future generations directions future research discussed gori giannini craparo caretti nannini madathil schuldberg assessment relationship use birth control pill characteristics mate selection sex med
objectives hospital episode statistics data used healthcare planning hospital reimbursements reliability data dependent accuracy individual hospitals reporting secondary uses service sus includes hospitalisation number coding accuracy parkinson disease hospital admissions tertiary centre birmingham assessed study design retrospective routine dataebased study methods retrospective electronic database search parkinson disease patients admitted tertiary hospital year period performed sus database using international classification disease codes local inpatient electronic prescription database prescription information communications system using medication prescriptions capture recapture methods used estimate number patients admissions missed databases results two databases july june patients parkinson disease accounted admissions admissions parkinson disease coded primary secondary diagnosis ninety one percent admissions recorded sus database capture recapture methods estimated number parkinson disease patients admitted period patients confidence interval supplementary search sus prescription information communications system undertaken using hospital numbers patients identified another admissions sus database estimated parkinson disease admissions study period conclusion accuracy disease coding critical healthcare policy planning must improved reporting parkinson disease admissions sus database repeated nationally expenditure parkinson disease admissions england estimated approximately sic million per year royal society public health published elsevier ltd rights reserved
three studies examined people express negative implicit attitudes toward individuals tattoo near face study participants completed implicit association test iat expressed moderately negative implicit attitudes toward individuals tribal tattoo one side neck study replicated study tattoo symmetrical suggesting negative affect processing fluency underlies implicit negative evaluation individuals tribal tattoo near face study showed dissociation explicit implicit attitudes toward individuals tribal tattoo near face negative implicit evaluation attenuated tattoo image objectively positive symbol implications displaying tattoo near face discussed
psorsc gene located coiled coil alpha helical rod protein cchcr corneodesmosin cdsn within psoriasis susceptibility locus psors performed comparative genomics analysis yet incompletely characterized psorsc gene determined expression pattern human tissues contrast cchcr common vertebrates investigated psorsc cdsn present exclusively mammals indicating latter genes originated evolutionary divergence mammals reptiles cdsn conserved aquatic mammals whereas psorsc orthologs contain gene inactivating frame shift mutations whales dolphins epidermal differentiation programme degenerated reverse transcription pcr screening demonstrated human tissues psorsc expressed principally epidermis weakly thymus psorsc mrna strongly upregulated terminal differentiation human keratinocytes vitro immunohistochemistry revealed exclusive expression psorsc granular layer epidermis cornifying epithelial cells hassall corpuscles thymus summary results identify psorsc keratinocyte cornification associated protein originated evolutionarily basal mammals undergone gene inactivation association loss skin barrier function aquatic mammals
neuroinflammation pathophysiological process present number neurodegenerative disorders alzheimer disease huntington disease parkinson disease stroke traumatic brain injury including chronic traumatic encephalopathy age related cns disorders although still much debate initial trigger neurodegenerative disorders progression disease broad range anti inflammatory drugs including cytokine suppressive anti inflammatory drugs csaids might promising therapeutic options limit neuroinflammation improve clinical outcome one promising csaids curcumin modulates activity several transcription factors stat kappa pro inflammatory molecular signaling pathways however normal curcumin preparations demonstrate low bioavailability vivo increase bioavailability preparations high bioavailability curcumin introduced achieve therapeutically relevant concentrations target tissues literature review aims summarize pharmacokinetic toxicity profile different curcumin formulations
purposethe purpose study describe medical record retrieval study validating claims based algorithms used identify seven adverse events special interest aesi medicare population methodswe analyzed medicare claims women postmenopausal osteoporosis men years age medicare national sample final cohorts included beneficiaries covered continuously months medicare parts enrolled medicare advantage starting follow identified beneficiaries using aesi algorithm randomly selected women men aesi medical record retrieval centers medicare medicaid services provided beneficiary contact information requested medical records directly providers without patient contact resultswe selected beneficiaries women men requested medical records overall received requested medical records observed small differences characteristics total population aesis compared randomly selected retrieval however differences seen selected retrieved retrieved records requested hospitals compared records requested physician offices retrieval differ sex vital status beneficiaries conclusionsour national medical record validation study claims based algorithms produced modest retrieval rate medical record procedures outlined paper could led improved retrieval previous medical record retrieval study copyright john wiley sons ltd
headache one common neurological symptoms reported childhood adolescence leading high levels school absences learning problems poor psychiatric conditions pediatric headache associated several neurological psychiatric comorbidities particular depression anxiety disorders sleep disorders epilepsy associated pediatric migraine goal article review comorbidities associated pediatric headache thereby enabling pediatric neurologists identify shared triggers develop synergistic management strategies address headache comorbidities
objective despite need effective pain communication pain difficult verbalise speech gestures frequently add information pain contained accompanying speech explored whether recipients obtain additional information gestures pain described methods participants viewed clips pain descriptions one four conditions speech speech gesture speech gesture face speech gesture face plus instruction short presentation explaining pain information gestures depict participants provided free text descriptions pain described responses scored amount information obtained original clips findings participants instruction condition obtained information speech condition obtained least comparisons conclusions gestures produced pain descriptions provide additional information pain recipients able pick without detriment uptake spoken information practice implications healthcare professionals may benefit instruction gestures enhance uptake information patients pain experiences elsevier ireland ltd rights reserved
introduction bone mineral density bmd breast density related reproductive hormone levels suggests bmd breast density could meaningfully associated serve surrogate markers breast cancer risk however studies investigated association bmd percent mammographic density making difficult draw meaningful conclusions materials methods conducted systematic review studies published electronic databases till april using following search terms bone density bone mineral density mammographic breast density breast density mammographic density identified articles met inclusion criteria review results bmd appear associated percent mammographic density bmd spine weakly positively associated percent mammographic density among postmenopausal women hormone users bmd hip legs positively associated percent mammographic density among premenopausal women hand one study reported inverse association bmd spine hip percent mammographic density among perimenopausal women conclusion review found evidence association bmd percent mammographic density
combination petri net modeling based heuristic search algorithms pnhs successfully applied integrated approach deal scheduling problems transformed search problem reachability graph several efficient algorithms proposed albeit using timed practical application algorithms requires appropriate tool facilitate development analysis however lack tool support optimization timed colored tcpn models based pnhs approach schedule generation complex data structure tcpn based scheduling often limited simulation based performance analysis also quite difficult evaluate strength tractability algorithms different scheduling scenarios due different computing platforms programming languages data structures employed light paper presents new tool called timspat developed overcome shortcomings existing tools features distinguish tool collection several algorithms xml based model integration event driven exploration timed state space including condensed variant localized enabling transitions introduction static place easy use syntax statements tool easily extensible integrated component existing simulators software environments comparative study performed real world eyeglass production system demonstrate application tool scheduling purposes elsevier ltd rights reserved
background aims prevalence fatty liver underscores need non invasive characterization steatosis ultrasound based controlled attenuation parameter cap despite good diagnostic accuracy clinical use cap limited due uncertainty regarding optimal cut offs andthe influenceof covariates therefore conducted individual patient data meta analysis methods review literature identified studies containing histology verified cap data probe vibration controlled transient elastography fibroscan grading steatosis receiver operating characteristic analysis correcting center effects used well mixed models test impact covariates cap primary outcome establishing cap cut offs distinguishing steatosis grades results data eligible papers provided comprising patients considering data overlap exclusion criteria patients included final analysis hepatitis hepatitis nafld nash steatosis distribution cap values influenced several covariates estimated shift nafld nash patients diabetics per bmi unit areas curves respectively optimal cut offs respectively conclusions cap provides standardized non invasive measure hepatic steatosis prevalence etiology diabetes bmi deserve consideration interpreting cap longitudinal data needed demonstrate cap relates clinical outcomes lay summary increase fatty liver patients chronic liver disease linked epidemic obesity invasive liver biopsies considered best means diagnosing fatty liver ultrasound based controlled attenuation parameter cap used instead factors underlying disease bmi diabetes must taken account registration prospero crd european association study liver published elsevier rights reserved
design pattern widely used software engineering field enables designers reuse existing mature designs high level perspective inspired idea novel approach proposed extract design patterns cad field first characteristics good design pattern analyzed model representing design patterns elaborated given set feature based cad models corresponding extraction approach proposed includes three important phases extracting reusable regions high cohesion low coupling moderate complexity form relative integrated function constructing candidate design patterns clustering reusable regions using graph oriented agglomerative hierarchical clustering algorithm determining final design patterns choosing candidate design patterns high frequency sufficient information finally design pattern extraction prototype system developed experimental results presented demonstrate effectiveness approach elsevier ltd rights reserved
aggressive behaviors become major public health problem early onset aggression lead outcomes substance abuse antisocial personality disorder among issues recent years increase research molecular genetic underpinnings aggressive behavior one candidate genes codes catechol methyltransferase comt comt involved catabolizing catecholamines dopamine neurotransmitters appear involved regulating mood contribute aggression common gene variant studied comt gene valine val methionine met substitution codon reviewing current literature gene variant aggressive behavior
objectives studies longitudinally extensive spinal cord lesions lescls neuromyelitis optica nmo focused gray matter relevant antigen aquaporin aqp abundant spinal white matter pathology nmo well characterized aimed clarify spinal white matter pathology lescls nmo methods analyzed spinal cord lesions eleven autopsied nmo nmo spectrum disorder nmosd cases also evaluated lescls three fewer spinal cord attacks tesla mri aqp antibody positive nmo nmosd patients aqp antibody negative multiple sclerosis patients results pathological analysis revealed seven cases aqp loss four predominantly demyelinating cases forty four lesions aqp loss cases involved significantly frequently posterior columns lateral columns anterior columns respectively posterior horn central portion anterior horn similarly affected respectively isolated perivascular inflammatory lesions selective loss astrocyte endfoot proteins aqp connexin present white matter frequent corr corr respectively mri indicated lescls frequently affected anti aqp antibody seropositive nmo nmosd corr corr respectively aqp antibody seronegative patients corr corr respectively involved seropositive patients respectively seronegative patients respectively conclusions nmo frequently extensively affects spinal white matter addition central gray matter especially isolated perivascular lesions astrocyte endfoot protein loss may emerge spinal white matter involvement may also appear early nmo similar cerebral white matter lesions
permanent bundle pacing long term right ventricular apical pacing associated increased risk death heart failure atrial fibrillation alternative sites pacing proven superior apical pacing cardiac resynchronization therapy crt using biventricular biv lead system indicated patients low left ventricular ejection fraction qrs prolongation remains nonresponse rate crt less effective nonleft bundle branch block conduction delay normal low normal left ventricular function past decade data feasibility advantages pacing bundle region review anatomy physiology available data permanent pacing current potential future applications
investigation article generalised nonlinear schrodinger maxwell bloch system picosecond optical pulse propagation inhomogeneous erbium doped silica optical fibre lax pair conservation laws darboux transformation generalised darboux transformation system constructed one two soliton solutions first second order rogue waves given soliton propagation discussed nonlinear tunneling effect solitons rogue waves investigated find detuning atomic transition frequency optical pulse frequency affects velocity pulse detuning small nonlinear tunneling effect affect energy redistribution soliton interaction iii dispersion barrier well effect soliton velocity whereas nonlinear well barrier nonlinear well barrier could amplify compress solitons rogue waves smoother manner dispersion barrier well dispersion barrier could attract nearby rogue waves whereas dispersion well repulsive effect
victims child abuse may increased risk acting suicide ideation although empirically tested estimated risk suicide attempts associated child abuse among individuals reported suicide ideation secondary analysis data population based canadian community health survey mental health population based survey included various structured questionnaires including composite international diagnostic interview assess mental illness suicidal thoughts behaviours approximately attempted suicide history child abuse poor mental health financial difficulties poor coping skills reporting suicide plan also associated increased prevalence attempting suicide adjusted factors child abuse associated fold increased prevalence suicide attempts individuals attempt suicide experience child abuse worse health social functioning adopting life course perspective understand trajectories suicide risk factors may inform prevention treatment
paper closed form solution arbitrary oriented hollow elastic ellipsoidal shell impacting elastic flat barrier presented assumed shell thin low speed impact due arbitrary orientation shell pre impact linear speed postimpact involves rotational translational speed analytical solution problem based hertzian theory johnson impact strength materials university manchester institute science technology edward arnold publication london vella analysis vella indentation ellipsoidal cylindrical elastic shells phys rev lett conjunction newtonian method due nonlinearity complexity impact equation classical numerical solutions employed therefore linearization method proposed closed form solution problem accomplished closed form solution facilitates parametric study type problems closed form solution validated explicit finite element method fem good agreement closed form solution results observed based analytical method maximum total deformation shell maximum transmitted force duration contact rotation shell impact determined finally concluded closed form solutions trustworthy appropriate investigate impact inclined elastic ellipsoidal shells elastic barrier
wealth associated differences people self concepts propose self concepts define types appeals effective motivating generosity across three field studies randomly assigned participants view appeal charitable organization emphasized agency pursuit personal goals communion pursuit shared goals appeal emphasized agency wealthier individuals reported greater willingness give donated money charity contrast appeal emphasized communion less wealthy individuals reported greater willingness give findings could explained relevant demographic characteristics age ethnicity gender work adds growing body research suggesting wealth inherently result selfishness generosity tailoring messages fit people self concepts possible catalyze giving across socioeconomic spectrum elsevier inc rights reserved
interest higher order tensors recently surged data intensive fields wide range applications including image processing blind source separation community detection feature extraction common paradigm tensor related algorithms advocates unfolding flattening tensor matrix applying classical methods developed matrices despite popularity techniques functional properties tensor changes upon unfolding currently well understood contrast body existing work focused almost exclusively matricizations consider possible unfoldings order tensor one one correspondence set partitions derive general inequalities norms arbitrary unfoldings defined partition lattice particular demonstrate spectral norm tensor bounded unfoldings obtain improved upper bound ratio frobenius norm spectral norm arbitrary tensor specially structured tensors satisfying generalized definition orthogonal decomposability prove spectral norm remains invariant specific subsets unfolding operations elsevier inc rights reserved
polycythemia vera chronic myeloproliferative neoplasm mpn characterized overactive janus kinase signal transducer activator transcription jak stat pathway mutations jak exons jak dominant clinical characteristics include erythrocytosis without leukocytosis thrombocytosis thrombotic events symptoms increased risk mortality mainly caused thrombotic events progression post polycythemia vera myelofibrosis ppv secondary acute myeloid leukemia saml important prognostic factors include age history thrombotic events although recent evidence indicated leukocytosis additional cytogenetic aberrations may also significant prognostic value first line therapies include aspirin phlebotomies significantly reduce incidence thrombotic events prolong survival cytoreductive treatment hydroxyurea approved conventional pegylated interferon alpha effective approved many countries initiated high risk inadequately controlled disease uncontrolled hematocrit leukocytosis thrombocytosis thrombotic events splenomegaly symptoms however patients may receive initial benefit first line therapy may become resistant intolerant due course although second line treatment options limited clinical trials shown efficacy ruxolitinib toward improving blood counts enlarged spleen symptoms potentially reducing thrombotic events identification patients uncontrolled important clinical care patients high risk complications future studies jak inhibitors agents alone combination needed test potential reduce rates thrombotic events transformation ppv saml
anagrelide ana drug specific platelet lowering activity used primarily registered second line drug essential thrombocythemia europe countries first line therapy usa licensed fda thrombocythemia myeloproliferative neoplasms mpn platelet lowering efficacy similar hydroxycarbamide around complete response partial response side effects common especially headache tachycardia usually subside disappear within weeks around patients stop ana therapy due side effects insufficient response studies treatment patterns europe show ana preferentially given younger patients probably concern possible leukemogenic effect common first line drug two randomized studies compared efficacy ana preventing thrombosis haemorrhage larger showing slightly better efficacy showing non inferiority ana recent observational year study patients shows low basically similar efficacy ana cytoreductive therapies ana appear inhibit fibrosis development probably due anticoagulation properties combination asa ana produces increased rate haemorrhage combination ana interferon ifn feasible effective patients insufficient platelet response mono therapy
study examined interpersonal attraction described craigslist org missed connections postings via quantitative content analysis randomly selected posts united states results indicated predicted missed connections postings contained combination multiple verbal spoken interactions greetings praise compliments nonverbal physical attractiveness eye contact nonverbal body movements attraction expressions posts included average two attraction expressions physical attractiveness frequently expressed form interpersonal attraction biological sex sexual orientation differences relation many attraction expressions included missed connections posts implications attraction online personal advertisement research described elsevier ltd rights reserved
clogging refers reduction riverbed hydraulic conductivity due difficulties determining thickness clogging layer leakage coefficient introduced used quantify recoverable portion bank filtrate determined several riverbank filtration rbf sites field tests using analytical solution results compared data similar experiments early severe river water pollution conjunction high water abstraction led partly unsaturated conditions beneath riverbed leakage coefficient determined water quality improvement increased alternative cost time efficient method presented estimate accurate leakage coefficients analytical solution based groundwater level monitoring data observation wells next river later feed numerical models analytical approach able reflect long term changes well seasonal variations recommendations application given based experience
metacognition refers range cognitive processes allow one form complex ideas self others use information navigate psychosocial challenges several studies early phase prolonged schizophrenia demonstrated significant deficits metacognitive ability present importantly associated significant functional impairment decreased quality life spite importance metacognitive impairment schizophrenia relatively little known biological substrates may contribute dysfunction study examined relationship resting state functional connectivity medial prefrontal cortex mpfc structure shown prior voxel based morphometry studies associated metacognition metacognitive function early phase psychosis cohort analyses revealed positive association resting state functional connectivity mpfc precuneus posterior cingulate structures metacognitive ability results provide evidence disrupted resting state connectivity structures relevant metacognitive dysfunction early phase psychosis may implications pathophysiological models complex cognitive deficits illness
purpose levothyroxine drug narrow therapeutic index applied small amounts micrograms makes interactions absorption phase clinically significant main aim article review present latest information factors affect gastrointestinal absorption drug methods relevant data collected using medline pubmed embase web science science direct scopus databases key words levothyroxine absorption searches limited specific publication types study designs dates languages reports highly variable amount information provided regarding study design methods heterogeneity studies statistical analysis performed findings many gastrointestinal disorders celiac disease atrophic gastritis lactose intolerance helicobacter pylori infection may impede absorption levothyroxine treatment disorders necessary monitor serum thyroid stimulating hormone free values reduce risk developing iatrogenic hyperthyroidism soybeans coffee greatest impact reduction absorption whereas vitamin ability increase conversely effect dietary fiber absorption yet fully understood research needed topic decrease absorption established clinically significant administered concomitantly cholestyramine colesevelam lanthanum calcium carbonate calcium citrate calcium acetate iron sulfate ciprofloxacin aluminum hydroxide sevelamer proton pump inhibitors effect taken consideration prescribing drugs concomitantly effects giardia lamblia infection influence orlistat polystyrene sulfonate raloxifene simethicone absorption poorly documented bariatric surgery sucralfate antagonist interactions well founded contradictory evidence available regarding existence additional research conducted elsevier journals inc rights reserved
competing food altricial semiprecocial bird nestlings behaviour well known sensitivity maternal androgens prenatal development whether similar effect present precocial species beg less well known therefore increased yolk testosterone levels within physiological range onset incubation study effects food competition behaviour domestic chicken gallus gallus domesticus found increase competitiveness testosterone treated male domestic chicks raising level females line decrease circulating plasma levels males direction levels females overall decrease androgen receptor densities prenatal treatment found previously hormones known long lasting organizing effects behaviour affect sexual differentiation vertebrates although research hormone mediated maternal effects productive studies describe ambiguous effects adulthood therefore followed animals adulthood recorded androgen dependent social behaviour secondary sexual characteristics body mass circulating plasma testosterone levels checked whether variables treatment dependent treatment near significant effect comb colour brightness chroma treatment caused shift towards female like phenotype suggests contrast earlier suggestions maternal androgens may interact disrupt sexual differentiation brain behaviour development secondary sexual characteristics association study animal behaviour published elsevier ltd rights reserved
development human eye requires coordinated interplay cells different origins optic cup neuroectodermal origin derives neural tube gives rise neuronal retina retinal pigmented epithelium epithelial layers ciliary body iris iris musculature lens displaced optic cup development originates surface ectoderm cells neural crest provide ocular mesenchyme ocular blood vessels mesodermal origin basic morphogenetic processes eye development completed end second month embryonic life however correct functioning maturation processes required completed birth several months examples aqueous humor circulation maturation cones foveola myelination optic nerve axons completion retinal vasculature
objectiveprior twin studies provide support single common factor contributes genetic environmental risk range disordered eating symptoms however common factor may indexed less well binge eating symptoms eating disorders body dissatisfaction weight preoccupation sought explore presence common factor test whether loadings differed across three key symptoms methoddisordered eating assessed via self report female twin pairs michigan state university twin registry resultswe detected common disordered eating factor influenced primarily additive genetic nonshared environmental influences however observed different loadings common factor symptom type factor loadings stronger moreover residual environmental genetic variances independent common factor larger discussionalthough three symptoms share common set genetic environmental influences risk may involve additional genetic biological environmental factors shared symptoms eating pathology wiley periodicals inc int eat disord
theories explain governance water integrated river basin management multilevel water governance point scalar configurations power critical determinants success failure article explains scalar configurations power water governance mirror chinese state influence water governance powerful ways use case yangtze river shanghai megacity yangtze estuary examples showing local jurisdiction exercises regulatory measures different types transjurisdictional water pollution regulatory measures mirror fluidity rigidity power configurations hydropolitics china china evolving water resource management institutions yet unable address scalar configurations power water governance
non verbal expressions pride convey status pride displays interpreted either authentic hubristic given negative stereotypes blacks hypothesized displaying pride blacks would rated higher hubristic lower authentic pride compared whites contrary predictions three experiments found consistent evidence whites judged hubristic blacks displaying pride effect occurred pride displayed unspecified study academic study work related context study effects largely specific pride displays function general race based response bias speculate counterintuitive findings might reflect negative reaction high status flaunting success
one triumph human mind ability place multitudinous array people encounter group members based racial characteristics one fundamental question remains answered whether invisible race faces nevertheless influence subsequent affective judgments employed continuous flash suppression cfs render race faces unperceivable affective priming task line line awareness checks employed provide stringent control partial awareness results revealed relative race faces imperceptible race faces significantly facilitated participants identification negative words suggesting race derogation bias faces presented consciously found race faces facilitated detection negative words also race faces facilitated detection positive words findings together provide novel strong evidence suggesting invisible racial faces bias affective responses elsevier inc rights reserved
background rotator cable important structure providing stress shield rotator cuff similar mechanism suspension bridge purpose evaluate visibility appearance rotator cable various conditions rotator cuff using indirect magnetic resonance arthrography material methods indirect arthrography images patients age range years normal rotator cuffs age range years tendinosis age range years partial thickness tears age range years full thickness tears supraspinatus infraspinatus tendons sst ists included study various rotator cuff conditions visibility appearance thickness width rotator cable relationships rotator cable appearance rotator cuff tear size rotator cuff thickness patient age assessed results sagittal images rotator cables visible normal rotator cuffs tendinosis partial thickness tears sst ists order normal cuff tendinosis partial thickness tear full thickness tear sst ists rotator cable tended become thicker respectively narrower respectively thickness rotator cable significantly positively correlated rotator cuff thickness normal rotator cuffs coefficient tendinosis sst ists coefficient correlated patients age conclusion sagittal plane indirect arthrography rotator cables visible appearance rotator cable changed according rotator cuff condition
years many efforts made problem constructing quality fault tolerant virtual backbones wireless network case wireless network consists physically equivalent nodes communication range unit disk graph udg widely used abstract wireless network problem formulated minimum connected dominating set problem udg far results focused designing constant factor approximation algorithm hard problem two positive integers satisfying however found structures algorithms extremely complicated thus would difficult implement use practice motivated observation paper introduces novel approximation algorithm problem algorithm based new technique first computes connected dominating set repeatedly decomposes connected block tree use graph structure improve connectivity becomes connected provide rigorous theoretical analysis prove proposed algorithm correct approximation ratio constant compare structure algorithm existing ones show algorithm much simpler understand implement
study proton conducting solid oxide fuel cell layered sofc prepared introducing nio perovskite oxide ruddlesden popper structure catalyst layer onto conventional bazr ceo delta nio bzcy anode situ dry reforming methane roles lanio catalyst layer reforming activity coking tolerance electrocatalytic activity operational stability anodes systematically studied lanio catalyst layer exhibits greater catalytic performance nio bzcy anode dry reforming methane outstanding coking resistance capability also demonstrated layered sofc consumes produced situ anode delivers much higher power output conventional cell nio bzcy anode improved coking resistance layered sofc results steady output voltage similar constant current density summary sofc lanio perovskite oxide potential energy conversion device conversion utilization cogeneration electricity syngas elsevier rights reserved
backgroundalcoholics anonymous world wide recovery mutual help organization continues arouse controversy large part concerns persist ostensibly quasi religious spiritual orientation emphasis united states institute medicine called studies effectiveness mechanisms behavior change mobc stimulating flurry federally funded research paper reviews religious spiritual origins program contrasts theory findings latest research methodliterature review summary synthesis studies examining mobc resultswhile original main text big book purports recovery achieved quasi religious spiritual means spiritual awakening findings studies mobc suggest may true minority participants high addiction severity beneficial effects seem carried predominantly social cognitive affective mechanisms mechanisms aligned experiences reported larger diverse membership detailed later social cognitive behaviorally oriented publications living sober written membership numbered million men women conclusionsalcoholics anonymous appears effective clinical public health ally aids addiction recovery ability mobilize therapeutic mechanisms similar mobilized formal treatment able free long term communities people live
lysosomes critical organelles cellular homeostasis used potential targets kill tumor cells inside many photo therapeutic methods developed overproduce reactive oxygen species ros trigger lysosomal membrane permeabilization lmp associated cell death pathway however technologies rely extra irradiation activate photosensitizers limits applications treating deep seated tumors widespread metastatic lesions work reports multifunctional nanocapsule achieve targeted lysosomal tumor cell death without irradiation real time monitoring drug effect encapsulating artemisinin dual protease light nanoprobe folate functionalized liposome nanocapsule specifically uptaken tumor cells via folate receptor mediated endocytosis enter lysosomes artemisinin reacts ferrous generate ros lmp associated cell death virtue confocal fluorescence imaging artemisinin location lysosome ros triggered lmp ultimate cell apoptosis visualized cathepsin caspase activatable nanoprobe notably artemisinin mediated ros evolving tumor therapy real time therapeutic monitoring successfully implemented living imaging tumor bearing mice broaden nanocapsule vivo theranostics may offer new opportunities precise medicine
essence radar stealth technology reduce radar cross section rcs object far possible paper structural radar absorption materials studyed analyzing rcs object several types structural radar absorption electromagnetic parameters materials designed electromagnetic scattering characteristics also calculated analyzed
background robot assisted manipulation promising solving problems understaffing risk infection gastro intestinal endoscopy however commonly used friction rollers existing systems potential risk deforming flexible endoscopes non uniform clamping methods paper presents robotic system standard flexible endoscope focuses novel gastroscope intervention mechanism gim provides circumferentially uniform clamping airbag gim works relay mechanism way similar manual operation shear stiffness airbag critical slipping force csf analysed determine parameters airbag fuzzy pid controller employed realize fast response high accuracy pneumatic actuation experiments performed evaluate accuracy stiffness csf vitro vivo animal experiments also carried results gim realized accuracy omicron push pull rotation without delivery resistance delivery resistance error caused airbag stiffness quadratic polynomial could used describe relationship csf pneumatic pressure conclusions novel gim could effectively deliver gastroscopes pneumatic driven clamping method proposed could protect gastroscope circumferentially uniform clamping force csf could properly controlled guarantee operating safety copyright john wiley sons ltd
study present new situ real time approach perform analyze scratch tests transparent coating substrates systems method allows observation contact region scratching process example thin tio layers exhibiting stress levels ranging tensile compressive deposited ion beam assisted evaporation onto plastic substrates failure processes obtained using increasing novel decreasing load scratch sequences linked internal stress coatings allowing one draw stress management diagram evaluate yield stress tio layers work enhances understanding optical films failure mechanisms outlines new pathway increase measurement reproducibility
wireless sensor networks wsns collection several small inexpensive battery powered nodes commonly used monitor regions interests collect data environment several issues exist routing data packets wsn crucial problem energy number routing approaches wsns address issue energy use different energy efficient methods paper presents brief summary routing related issues wsns recent energy efficient data routing approaches reviewed categorized based aims methodologies traditional battery based energy sources sensor nodes conventional energy harvesting mechanisms widely used energy replenishment wsn reviewed new emerging energy harvesting technology uses piezoelectric nanogenerators supply power nanosensor type sensors charged conventional energy harvesters explained energy consumption reduction routing strategies wsn also discussed furthermore comparisons variety energy harvesting mechanisms battery power routing protocols discussed presented eliciting advantages disadvantages specific feature finally highlight challenges future works research domain presented
central nervous system mucormycosis aggressive fungal infection often ending fatality usual circumstance immunocompromised individual presenting rapidly progressive rhinocerebral involvement extremely rare variant central nervous system mucormycosis isolated basal ganglia immunocompetent intravenous drug user detailed manuscript patient aggressively treated aspiration fungal abscess long term intravenous antifungal agents
assess accuracy reduced dose low chest reconstructed model based iterative reconstruction mbir detecting usual early complications following pulmonary transplantation compared standard dose chest reconstructed adaptative statistical iterative reconstruction asir institutional review board approved prospective study patients provided written informed consent two thoracic radiologists independently evaluated examinations performed routinely patients months following lung transplantation detection evolution usual pleuropulmonary complications subjective image quality examination consisted successive acquisition unenhanced noise index asir mas slice mbir mean ctdivol mgy respectively complications found examinations sensitivity negative predictive value detection pneumonia fungal infection pleural effusion pneumothorax bronchial dehiscence stenosis compared image quality graded good examinations mbir accurate compared delineating usual pleuropulmonary complications months following pulmonary transplantation might used routinely early monitoring pulmonary allografts aeuro cent early chest complications frequent following pulmonary transplantation aeuro cent key role detection follow aeuro cent low mambir accurate monitoring lung allograft early pleuropulmonary complications aeuro cent mbir chest allows six fold dose reduction compared standard
web first used telecontrol medium recent times web based telecontrol used educational option providing students remote access laboratory hardware literature reporting initial studies telelaboratories speaks encouraging responses students little literature actually addresses quality learning outcomes alternative access mode recent comparative study department mechanical manufacturing engineering university melbourne melbourne australia randomly allocated cohort third year students one three separate access modes proximal web based remote simulation perform laboratory class range tools used measure students learning outcomes perceptions class statistically significant differences found groups learning outcomes students perceptions laboratory class ways engage learning experience
general spontaneous evaluations strangers based faces shown reflect judgments persons intention ability harm evaluations mapped onto space defined dimensions trustworthiness intention dominance ability beyond general evaluations focus specific personality judgments derived big two big five personality concepts particular investigate whether big two big five personality judgments mapped onto space defined dimensions trustworthiness dominance results indicate judgments big two personality dimensions almost perfectly map onto space contrast least big five dimensions neuroticism extraversion conscientiousness beyond space indicating additional dimensions necessary describe specific face based personality judgments accurately building evidence model big two big five personality dimensions real facial photographs results validation studies show big two big five perceived reliably across different samples faces participants moreover results reveal participants differentiate reliably different big two big five dimensions importantly high level agreement differentiation personality judgments faces likely creates subjective reality may serious consequences perceived notably consequences ensue subjective reality socially shared irrespective judgments validity methodological approach introduced might prove useful various psychological disciplines
paper treats noise control engineering using double leaf partition means analytical approach technique widely used due efficiency providing better acoustic insulation wide frequency range compared single leaf structures double leaf partition construction comprising two leaves separated air space cavity dynamically couples two leaves therefore analysis complicated introduces several scientific aspects paper deals common case double leaf partitions double glazing analytical approach used analyze influence different parameters acoustic insulation plate thickness gap width etc several simulations performed different double glazing configurations assess influence variables final acoustic insulation low frequencies better performance achieved thicker air layers higher frequencies thinner air layer preferable use wall panels different mass resulted wall performing better particularly high frequencies published elsevier ltd
paper presents research use methods computer image analysis artificial neural modeling process assessing quality greenhouse tomatoes variety cappricia subject study tomatoes sizes colours include intermediate colours process image acquisition obtaining empirical data conducted throughout entire growing season period first harvest middle may last harvest beginning november satisfactory quality characteristics obtained case rbf rbf models rbf network whose output variable colour tomato training quality validation quality test quality rmse rate network training training set validation set test set rbf network variables colour hardness network characterised training quality validation quality test quality rmse rate network training network validation network test research showed performing correct classification requires taking two digital images examined tomatoes one stem one front tomato generating training sets contain average values extracted characteristics elsevier rights reserved
hyperspectral signatures provide abundant information regarding health status crops however difficult discriminate biotic abiotic stress study case simultaneous occurrence yellow rust disease symptoms nitrogen stress investigated using hyperspectral features ground based hyperspectral imaging system hyperspectral images healthy diseased plant canopies taken rothamsted research specim spectrograph five wavebands width utilized accurate identification stress healthy plant conditions technique developed used hybrid classification scheme consisting hierarchical self organizing classifiers three different architectures considered counter propagation artificial neural networks supervised kohonen networks skns fusion total spectra collected used testing results biotic abiotic stress identification appear promising reaching three architectures proposed approach aimed sensor based detection diseased stressed plants treated site specifically contributing effective precise application fertilizers fungicides according specific plant needs
last decade serotonin transporter gene promoter polymorphism httlpr likely studied genetic variant predictor antidepressant response nevertheless results consistent across studies previous meta analysis since various factors seem modulate effect antidepressant response aim clarifying issue systematically reviewed literature selecting studies exploratory analysis without priori hypothesis analyzed separately studies performed caucasians asians tested two phenotypes remission response rates three genotype comparisons versus kiss versus versus using cochrane review manager evaluations performed separately ssris mixed drugs possible clinical modulators investigated exploratory analysis found association allele genotype remission analysis split ethnic group caucasians found association allele response remission ssri group marginal association allele remission survived pooling together mixed antidepressant treatments asians small effect httlpr remission mixed antidepressants detected gender age age onset modulated association caucasians gender age depression severity baseline modulated association asians conclusion caucasians httlpr may predictor antidepressant response remission asians appear play major role elsevier ecnp rights reserved
solution large sparse systems linear constraints base interactive solvers physically based animation soft body dynamics focus applications hard tight per frame resource budgets video games solution soft body dynamics needs computed milliseconds linear iterative methods preferred cases since provide approximate solutions within given error tolerance short amount time present parallel randomized gauss seidel method effectively employed enable animation soft objects discretized large irregular triangular tetrahedral meshes beginning frame partition set equations governing system using randomized graph coloring algorithm unknowns equations belonging partition independent equations belonging partition solved time parallel algorithm runs completely gpu support changes constraints topology tested method solver soft body dynamics within projective dynamics position based dynamics frameworks show algorithmic simplicity iterative strategy enables great numerical stability fast convergence speed essential features physically based animations fixed small hard time budgets compared state art found method faster scale better providing stabler solutions small time budgets
iberian pyrite belt ipb rich sulfide deposits intensively exploited generating huge problem contamination odiel river acid mine drainage amd source clean river along long reach receives five discharges acid mine waters concepcion san platon esperanza poderosa agrio river drains amd contaminated water rio tinto mines flows hydrogeochemical characteristics amd sources studied agrio river main contributor acidity sulfate metals odiel river due high flows pollutant concentrations san platon poderosa mines high sulfate metal concentrations although sources characterized low moderate flows concepcion lowest concentrations higher flows composition amd sources seem controlled mineralogy deposits geochemical processes strong seasonal variations observed amd sources others constant throughout year authors published elsevier
reserpine irreversible inhibitor vesicular monoamine transporter vmat used study parkinson disease screening antiparkinsonian treatments rodents recently repeated treatment low dose reserpine proposed progressive model rats treatment show progressive catalepsy behavior oral movements spontaneous motor activity decrement parallel compared wistar rats spontaneously hypertensive rats shr resistant acute reserpine induced oral dyskinesia aimed assess whether shr would present differential susceptibility repeated reserpine induced deficits progressive model male wistar shr rats administered subcutaneously injections reserpine mgkg vehicle every day motor activity assessed catalepsy oral movements open field tests reserpine treated wistar rats presented increased latency step catalepsy test impaired spontaneous activity open field hand increase oral movements reserpine treated strains although reduced magnitude latency instauration shr day withdrawn period strains recovered motor impairment shr animals expressed reduced latencies reach control levels finally performed immunohistochemistry tyrosine hydroxylase synuclein alpha syn last injection days withdrawn reserpinetreated animals presented reduction increase alpha syn immunoreactivity substantia nigra dorsal striatum dstr recovered days withdraw furthermore shr rats resistant reserpine induced decrement substantia nigra presented reduced immunoreactivity syn inthe dstr relative wistar rats irrespective treatment effect accompanied increase malondaldhyde mda striatum reserpine treated wistar rats shr presented reduced mda control reserpine conditions relative wistar strain conclusion current results show shr resilient motor neurochemical impairments induced repeated low dose reserpine protocol findings indicate neurochemical molecular genetic differences shr strain potential relevant targets study susceptibility
paper reveals logistics make least annual operational expenditure costs offshore wind farms annual operational expenditure found vary factor making share levelized cost energy offshore wind range key findings month research project targeting cost reduction initiatives offshore wind systems findings reveal cost measures difficult implement due cultural differences implementation efforts rendered personnel located offshore harsh sea environment stark contrast shore based office personnel develop studies directing cost reduction efforts paper details company motivation join industry wide cost reduction initiatives business case offshore wind operations maintenance logistics yielding savings levelized cost energy included expand working hours daytime also work night
group focused moral foundations gmfs moral values help protect group welfare sharply divide conservatives liberals religiously devout non believers however little evidence drives divide moral foundations theory model motivated social cognition associate group focused moral foundations differences conflict detection resolution capacity opposing directions individual differences conflict detection resolution implicate specific neuroanatomical differences examining neuroanatomy thus affords objective non biased opportunity contrast influential theories report increased adherence group focused moral foundations strongly associated whole brain corrected reduced gray matter volume key regions conflict detection resolution system anterior cingulate cortex lateral prefrontal cortex reduced gray matter reliably associated reduced neural cognitive capacity findings support idea outlined model motivated social cognition belief group focused moral values associated reduced conflict detection resolution capacity elsevier rights reserved
paper focuses description operation principle inherent adams electric motor generator fitted permanent magnets made rare earth ndfeb checking basic design used fem electromagnetic simulation made ansys workbench ansys maxwell adams motor generator basically assembled slight deviations original patent respect stator magnetic circuit design resultant speed torque characteristics obtained measurement input power values processed determine machine efficiency
introduction important elucidate psychologically positive aspects childbirth mothers negative aspects perinatal depression study aimed examine psychological growth childbirth related variables focussing five factors posttraumatic growth relating others new possibilities personal strength spiritual change appreciation life methods pregnant women mid pregnancy consecutively recruited women hospital japan followed month childbirth psychological growth assessed posttraumatic growth inventory results among participants completed follow assessments month childbirth multivariable regression analysis revealed primipara higher resilience less fear childbirth associated posttraumatic growth factors relating others new possibilities high resilience less fear childbirth also associated personal strength hand primiparous high depressive symptoms associated greater appreciation life variables associated spiritual change discussion findings suggest giving birth first time could highly challenging life event well opportunity leads ptg giving birth low fear might lead mothers psychological growth hand appreciation life might need attention might signify sorts coping response findings contribute understanding psychological changes experienced mothers
time series prediction become popular various kinds applications weather prediction control engineering financial analysis industrial monitoring etc deal real world problems often faced missing values data due sensor malfunctions human errors traditionally missing values simply omitted replaced means imputation methods however omitting missing values may cause temporal discontinuity imputation methods hand may alter original time series study propose novel forecasting method based least squares support vector machine lssvm employ input patterns temporal information defined local time index lti time series data well local time indexes fed lssvm forecasting without imputation compare forecasting performance method imputation methods experimental results show proposed method promising worth investigations
importance scurvy remains prevalent certain populations including addicts people low socioeconomic status severely malnourished classically presents follicular hyperkeratosis perifollicular hemorrhage lower extremities well bleeding areas gingiva joints case presentation literature review highlights common pathophysiological findings associated scurvy current methods diagnosis treatment observation patient described case presented sudden oligoarthritis purpura lower extremities following progression patient symptoms low vitamin serum concentration patient treated vitamin supplementation dramatically improved considered result underlying vitamin deficiency secondary insufficient fruit vegetable intake due allergies conclusions relevance case highlights importance maintaining high index suspicion scurvy atypical presentations purpura better explained another disease additional populations high risk vitamin deficiency early diagnosis either primary care physician dermatologist expedite treatment process improve patient prognosis
commonly adopted method dumping dredge spoil sea using split hull barges leads considerable sediment loss water column subsequent dispersion fine material pose risk sensitive downstream habitats coral reefs containing sediment loads using stitched closed geotextile bags practiced minimizing loss contaminated sediment expensive terms operational efficiency following promising observations initial laboratory trials plunging partially shielded sediment loads released open sea studied partial shielding achieved rigid open containers well flexible open bags loss sediment modes shielding measured observed even limited unstitched shielding effective debilitating entrainment water descending load particular long sleeved flexible bags practically self eliminated exposure load thus losses elsevier ltd rights reserved
osteophyte one inevitable consequences progressive osteoarthritis main characteristics cartilage degeneration endochondral ossification pathogenesis osteophyte formation fully understood date work metabolomic approaches employed explore potential mechanisms osteophyte formation detecting metabolic variations extracts osteophyte cartilage tissues uninvolved control cartilage tissues based platform ultraperformance liquid chromatography tandem quadrupole time flight mass spectrometry well use multivariate statistic analysis univariate statistic analysis osteophyte group significantly separated control group orthogonal partial least squares discriminant analysis models indicating metabolic state osteophyte cartilage changed total metabolic variations validated mass spectrum match tandom mass spectrum match standards match mainly included amino acids ramie acids glycerophospholipids fatty acyls metabolites related specific physiological pathological processes collagen dissolution boundary layers destroyed self restoration triggered etc might associated procedure osteophyte formation pathway analysis showed phenyialanine metabolism highly correlative degenerative process findings provided direction targeted metabolomic study insight reveal molecular mechanisms ostophyte formation
role veterinary forensic pathologist investigation animal abuse neglect beyond documenting condition animals presented evidence although animal cruelty moral concern crime law enforcement response crimes often enhanced recognition crimes animals indicators ongoing crimes people predictors potential interpersonal violence understanding common motives underlying animal cruelty aid pathologist asking appropriate questions authors review forms pathology evidence commonly seen various presentations animal cruelty understanding forms evidence help pathologist describe findings significant assessing potential risks alleged perpetrator may pose animals humans
internet organizational network security still threatened devastating malicious activities given continuous escalation attacks terms frequency sophistication stealthiness paramount importance generate effective cyber threat intelligence aim inferring attributing characterizing mitigating misdemeanors nevertheless imperative tasks partially impeded lack approaches produce prompt accurate actionable intelligence investigating various network traffic sources paper propose evaluate big data architecture rooted real time network traffic processing distributed messaging scalable data storage key benefit proposed architecture automates aggregation transformations heterogeneous network data allowing greater focus cyber threat intelligence analytics rather data management aggregation reconciliation formatting empirical evaluations investigating application machine learning analytics exploiting artifacts resulting prototype proposed architecture using real network traffic indeed demonstrate practicality effectiveness added value proposed architecture
background isometheptene sympathomimetic drug effective acute migraine treatment composed two enantiomers diverse pharmacological properties study investigated pithed rats cardiovascular effects isometheptene isometheptene pharmacological profile potent enantiomer methods effects bolus injections isometheptene racemate isometheptene isometheptene heart rate blood pressure analyzed control experiments enantiomer producing pronounced tachycardic vasopressor responses analyzed rats receiving injections prazosin rauwolscine propranolol intraperitoneal reserpine results compared isometheptene isometheptene produced greater vasopressor responses whilst compounds equipotently increased heart rate tachycardic responses isometheptene abolished propranolol remained unaffected antagonists contrast vasopressor responses isometheptene practically abolished prazosin interestingly reserpine tachycardic responses isometheptene abolished whereas vasopressor responses attenuated subsequently abolished prazosin conclusions different cardiovascular effects isometheptene enantiomers probably due differences mechanism action namely mixed sympathomimetic action isometheptene tyramine like action direct stimulation alpha adrenoceptors exclusively tyramine like action isometheptene thus isometheptene may represent superior therapeutic benefit antimigraine agent
tablighi jama transnational islamic missionary movement propagates greater religious devotion observance gambia opens door new experience gendered muslim piety tabligh islamic missionary work results novel roles women actively involved public spherea domain usually defined male provide wives time engage tabligh tablighi men share domestic workload although generally considered women work gambian society contrary conventional approach scholarship gender islam study inversion gender roles terms muslim women empowerment muslim men emancipation gambian branch jama reconfiguration gender norms seems motivated tablighis wish return purported origins islam following example prophet wives tablighi women actively engage tabligh taking muhammad example tablighi men taken part wives household chores paradoxically reconfiguring gender norms gambian tablighis eventually reinstate patriarchal gender order
insufficient detoxification overproduction reactive oxygen species ros induce cellular tissue damage generated reactive oxygen metabolites become exacerbating factors dermatitis keishibukuryogan yokuinin kbgy traditional japanese medicine prescribed treat dermatitis acne vulgaris aim verify antioxidant properties kbgy identify active constituents blood pharmacokinetic techniques chemical constituents quantified extracts kbgy crude components plasma rats treated single oral administration kbgy twenty three kbgy compounds detected plasma including gallic acid prunasin paeoniflorin azelaic acid reported effective inflammation kbgy decreased level diacron reactive oxygen metabolites roms plasma ros scavenging lipid hydroperoxide lpo generation assays revealed gallic acid methylgallic acid catechin lariciresinol possess strong antioxidant activities gallic acid active similar concentration maximum plasma concentration therefore findings indicate gallic acid important active constituent contributing antioxidant effects kbgy kbgy active constituents may improve redox imbalances induced oxidative stress optional treatment skin diseases
study examined whether cognitive reserve alters relationship magnetic resonance imaging mri measures cortical thickness risk progression normal cognition onset clinical symptoms associated mild cognitive impairment mci analyses included participants biocard study participants cognitively normal largely middle aged age baseline mri scan average years longitudinal follow developed clinical symptoms mci dementia time baseline clinical symptom onset years mean thickness measured eight vulnerable cortical regions cognitive reserve indexed composite score consisting years education reading vocabulary measures using cox regression models cortical thickness independently associated risk clinical symptom onset within years baseline suggesting neuronal injury occurring proximal symptom onset direct association clinical outcomes regardless contrast significant interaction mean cortical thickness risk progression years baseline suggesting individuals high better able compensate cortical thinning beginning occur earliest phase
port scan detection one important topics network security received lots attention researchers however slow port scan attack deceive existing ids besides unreasonable typical detection decide whether probe based precise threshold especially feature values around threshold without taking uncertainty consideration address problems novel approach proposed collecting traffic statistics information called access port set aps address time windows several traffic features extracted aps considered multiple evidences indicate probe evidence three probabilities concerned evaluate likelihood probe occurring include probabilities support nonsupport uncertainty comprehensive evidence obtained combination multiple evidences evaluate probe threaten several experiments performed evaluate approach darpa mit datasets generated attack datasets experimental results show feasibility approach terms detection accuracy effectiveness mechanism applied port scan detection also precise threshold based situations traffic abnormal analysis intrusion detection copyright john wiley sons ltd
functional magnetic resonance imaging fmri studies psychiatry use various tasks identify case control differences patterns task related brain activation differently activated regions often ascribed disorder specific functions attempt link disease expression brain function undertook systematic meta analysis data task fmri studies examine effect diagnosis study design spatial distribution direction case control differences brain activation mapped atlas regions coordinates case control differences derived task fmri studies schizophrenia bipolar disorder major depressive disorder anxiety disorders obsessive compulsive disorder comprising observations derived participants fmri tasks classified according research domain criteria rdoc investigated whether diagnosis rdoc domain construct use regions interest whole brain analyses influenced neuroanatomical pattern results considering primary studies found effect diagnosis amygdala caudate nucleus effect rdoc domains constructs amygdala hippocampus putamen nucleus accumbens contrast whole brain studies identify significant effect diagnosis rdoc domain construct results resonate prior reports common brain structural genetic underpinnings across disorders caution attributing undue specificity brain functional changes forming explanatory models psychiatric disorders authors human brain mapping published wiley periodicals inc
direction study outcomes job requirements postgraduate students outcome based education implemented curriculum group design application control engineering discipline wuhan university science technology based demand analysis master full time professional degree combined demand society enterprises system structure curriculum group pays emphasis practical ability student driven students final study outcome curriculum group control engineering discipline three blocks basic curriculums core curriculums expanding curriculums educational quality evaluated variety student outcomes
paper presents electrical machine novel stator geometry intended small unmanned aircraft machine part hybrid propulsion system operating conjunction internal combustion engine main study involves operations motor mode electric machine performs main propulsion well additional power source starter hybrid drive purpose investigation experimental evaluation electric parameters electric machine motor mode particular achievable torque different speeds several loads compare results initial requirements
grid connected converter control grid voltage feedforward usually introduced suppress influence grid voltage distortion converter grid side current however owing time delay control systems suppression effect grid voltage distortion seriously affected paper positive effects grid voltage feedforward control analyzed detail time delay caused low pass filter lpf voltage filtering circuits digital control summarized order reduce time delay effect performance feedforward control voltage feedforward control strategy time delay compensation proposed leading correction feedforward voltage used optimal leading step used strategy derived analyzing phase frequency characteristics lpf implementation digital control using optimal leading step delay feedforward path counteracted performance feedforward control terms suppressing influence grid voltage distortion converter output current improved validity proposed method verified simulation experiment results
mesh segmentation considered important process field computer graphics fundamental process different applications shape reconstruction reverse engineering models retrieval cad cam applications etc consists subdividing polygonal surface patches uniform properties either geometrical point view perceptual semantic point view paper unsupervised clustering techniques mesh segmentation problem introduced means fuzzy means fcm clustering techniques selected development proposed clustering based mesh segmentation techniques since mesh faces considered main element clustering technique applied dual mesh euclidean distance used distance measure compute matching mesh elements based empirical results benchmark dataset mesh models fcm based mesh segmentation technique outperforms means based one terms accuracy consistency human segmentations
use type nanoscale zeolite powder composite low density polyethylene ldpe obtained different doping concentration composite materials zeolite weight percentage using broadband dielectric spectrometer measure analyse dielectric performance relatively wide frequency range lopeizeolite composite pure polyethylene different temperature test results show increase concentration doping lope zeolite composite materials dielectric constant gradually declined zeolite weight percentage zeolite material framework silicon oxygen aluminum porous structure empty space framework make dielectric constant lopeizeolite composite reduced temperature rise dielectric constant lopeizeolite composite pure polyethylene declining curve dielectric constant goes zeolite weight percentage frequency time dielectric losses composite material also obvious changes low frequency area dielectric loss lope zeolite composite decrease similar area lower pure polyethylene similar area dielectric losses lope zeolite composite peak samples frequency dielectric losses rise kind phenomenon also concerned framework zeolite within lope zeolite composite new type composite material keeps performance polyethylene reduce dielectric constant change dielectric loss features contribute improve breakdown strength materials
paper presents smart sensory platform based field programmable analog array fpaa support wide variety mems sensors applications discrete time continuous time dual mode fpaa proposed improve analog signal conditioning flexibility gain programmable low noise multi mode sensor readout circuit roc designed versatile sensor weak signal acquisition sense capacitive voltage current signal microcontroller mcu bit sar adc used digital signal processing analog digital conversion platform implemented cmos process multi mode sensor readout circuit achieves input referred noise voltage current capacitive signal readout mode respectively analog signal processing functions pga filter adder comparator realized configuration dual mode fpaa sar adc shows bit effective number bits power consumption msps sampling rate
social anxiety disorder sad antisocial personality disorder aspd often thought comorbid however recent research suggests existence sad subtype characteristics atypical sad common aspd thus explored two competing hypotheses sad aspd represent opposite ends single dimension sad aspd exist two separate dimensions may positively correlated data obtained national epidemiological survey alcohol related conditions sad aspd related greater impairment psychiatric comorbidity either disorder alone sad aspd group also likely seek treatment sad symptoms drink antisocial acts sad group presence sad individuals aspd vice versa appear provide protective benefits sad aspd appear two separate correlated disorders elsevier ltd rights reserved
self healing oxidation spark plasma sintered taalc investigated using newly developed wedge loaded compact specimen determine strength recovery single specimen previous work predicted dominant oxidation leading dense strong reaction products result favourable healing properties however crack gap filling strength recovery taalc achieved oxidation degrees oxidation degrees synthetic atmospheric air resulted porous oxides alo formation dta degrees revealed two step reaction process final products tao taalo study shows kinetics may overrule self healing max phase design criteria based thermodynamics elsevier ltd rights reserved
pod propeller propulsion device installed externally ship hull pod system comprises short propulsion shaft propulsion electric motor mounted cases propulsion achieved means fixed pitch propellers powered synchronous motor conventional permanent magnet asynchronous electric motor fitted inside pod amongst highest failure indices main electric motor parts stator windings core rotor windings slip ring electric connectors high failure rates attributed mainly high temperature development windings leading excessive overheating stresses indicating motors properly selected according stressful conditions subject operate paper deals design procedure surface mounted permanent magnet synchronous motor application podded main propulsion motor specifically azipod system outboard marine propulsion unit engine hull rotatable around shaft directly connected propeller
objectivethe aim study explore preferred acculturation strategies adopted indian subcontinental adolescents living australia study also examined demographic ethnocultural psychological factors could influence subcontinental migrant groups attitudes towards acculturation acculturation strategies methoda cross sectional design used dependent variables four acculturation strategies multivariate data analysis conducted pearson correlation analysis variance step wise multiple regression analyses performed establish relationships among study variables resultsintegration preferred strategy marginalisation least preferred strategy ethnic groups acculturation preferences predicted partly adolescents ethnicity ethnic identity friendship choices acculturative stress sense mastery self concept gender findings provide significant information acculturation practices indian subcontinental adolescents including ethnic identity search commitment psychological well integration strategies conclusionseducational institutions could benefit increased awareness needs culturally diverse groups especially information incorporated teacher training materials inclusion intercultural relations courses academic curriculum would promote harmonious relations culturally diverse ethnic groups
accepted paradigms mainstream neuropsychiatry appear incompletely adequate various cases offer equivocal analyses however growing number new approaches proposed suggest emergence paradigm shifts area particular quantum theories mind brain consciousness seem offer profound change current approaches unfortunately quantum paradigms harbor least two serious problems first simply models theories assumptions convincing experiments supporting claims second deviate contemporary mainstream views psychiatric illness revolutionary ways suggest possible way integrate experimental neuroscience quantum models order address outstanding issues psychopathology key role played phenomenon called stream consciousness linked called gamma synchrony clearly demonstrated eeg data novel proposal unipolar depressed patient could seen subject altered stream consciousness particular clues suggest depression linked increased power stream consciousness additionally suggested approach depression might extended psychopathology general potential benefits diagnostics therapeutics neuropsychiatry elsevier ltd rights reserved
examined effects light intensity metabolism antioxidant enzymes expression related genes haliotis discus hannai ino determine optimal lighting conditions aquaculture animals succinate dehydrogenase activity significantly lower animals exposed light intensities mol lactate dehydrogenase activity lactic acid content significantly higher compared animals dark exposed mol throughout experiment however ros contents light intensities mol peaked expression levels genes encoding catalase cat thioredoxin peroxidase tpx sigma glutathione transferase gst glutathione transferase gst also began increase cat glutathione peroxidase activities significantly higher animals dark exposed mol ros content mol began decrease gpx activity malondialdehyde mda content also gradually decreased followed increases ros mda later reach respective peaks gene expression levels tpx gst gst heat shock protein hsp cat began decrease later suggesting excessive accumulation ros may caused oxidative damage tissues light intensity mol expression levels tpx gst gst hsp genes total antioxidant capacity activity peaked ros content significantly higher group later however gene expression levels tpx gst gst hsp hsp cat reduced glutathione content began decrease indicating antioxidant system unable perform normal physiological functions withstand long term stress adverse environmental factors results suggest light intensity controlled mol discus hannai aquaculture maintain organism normal physiological metabolism statement relevance disc abalone haliotis discus hannai economically important shellfish china demand growing high protein low fat seafood tons discus hannai harvested aquacultural sources supply currently meet consumer demand recent years natural habitat discus hannai declined result overfishing marine reclamation water pollution among others leading sharp decrease numbers discus hannai wild thus development aquacultural system farming discus hannai well protection wild focus current research light including photoperiod quality intensity one key environmental factors influencing growth culture survival aquatic organisms evolutionary time organisms evolved physiological behavioral mechanisms enable adapt diurnal fluctuations light chinese traditional abalone aquaculture sunshade net usually used photophobic nature abalone particular aquaculturist usually provides darkened setting adult abalones increase food intake rate facilitate growth promote gonadal development abalones natural environment light intensity water area relatively stable suggesting key regulative effect light intensity growth development gao found dark environment adversely affected daily aquaculture production also associated lower growth rate compared animals reared higher light intensities lower food conversion efficiency greater energy losses excretion feces physiological metabolism antioxidant defense systems may therefore key indicators measuring suitability light intensity aquaculture production therefore examined effects light intensity metabolism antioxidant defense system expression related genes discus hannai using light emitting diode led replace conventional fluorescent light source results study improve understanding physiological tolerance antioxidant defense characteristics abalone different light intensities enable optimization environmental light conditions abalone aquaculture published elsevier
results computer simulations certain electronic properties austenite phase alloy presents cluster approach used self consistent density functional methods exploited
numerical morphological modeling braided rivers using physics based approach increasingly used technique explore controls river pattern applied perspective simulate impact channel modifications paper assesses depth averaged nonuniform sediment model delftd predict morphodynamics long reach braided rees river new zealand single high flow event evaluation model performance primarily focused upon using high resolution digital elevation models dems difference derived fusion terrestrial laser scanning optical empirical bathymetric mapping compare observed predicted patterns erosion deposition reach scale sediment budgets calibrated model supplemented planform metrics braiding intensity extensive sensitivity analysis model functions parameters executed including consideration numerical scheme bed load component calculations hydraulics bed composition bed load transport bed slope effects bank erosion frequency calculations total predicted volumes erosion deposition corresponded well observed difference predicted observed volumes erosion less factor two characterizes accuracy gaeuman bed load transport formula grain size distributions best represented using two intervals unsteady flows results sensitive morphological time scale factor approach comparing observed predicted morphological sediment budgets shows value using natural experiment data sets model testing sensitivity results transferable guide delftd applications rivers
numerical investigation carried study laminar liquid flow coupled heat transfer performance rectangular microchannel heat sink mchs equipped wire coil inserts distilled water temperature dependent thermophysical properties employed perform simulation effects length arrangement wire coil inserts flow heat transfer characteristics mechanism heat transfer enhancement wire coil inserted mchss analyzed using first second law thermodynamics study also propose frication factor heat transfer correlations mchss wire coils results show heat transfer performance mchs enhanced effectively due longitudinal vortexes caused wire coils flow resistance increased simultaneously mchs long wire coil placed center line microchannel shows best heat transfer performance enhancement factor heat flux overall performance best among five configurations using principle entropy generation minimization using performance evaluation criteria pec best performance limited low reynolds number best overall performance using pec high reynolds mchs three segments short wire coil placed center line microchannel elsevier ltd rights reserved
paper propose communication support tool understanding emotion unstable narrowband network tool reflect emotion selected voice character based real time communication chat voice data transmitted asynchronously stored local storage order evaluate effectiveness communication play voice data according emotion implemented web based voice contents classified according massage types primitive emotion
power spectral analysis heat beat variations heart rate interval obtained using invasive contact sensor become widely used quantify cardiac autonomic regulation also leads estimation stress state aim study estimate stress state respiratory waves obtained monitoring thorax abdomen activity using ghz wideband radar without making contact human body avoids additional preparations physical sensor attachment special clothing useful certain healthcare applications possible estimate stress state heart respiratory rate variability may able help stress management sleeping driving working nonrestrictive noninvasive paper found estimate stress state even respiratory rate variability relationship heart rate respiration propose estimating technique stress state using constant false alarm rate respiratory rate variability effectiveness also quantitatively evaluated experiment
paper provided validated modeling simulation degree freedom vehicle longitudinal model drive train component series hybrid electric vehicle dof vehicle dynamics model consisted tire subsystems permanent magnet synchronous motor acted prime mover coupled automatic transmission hydraulic brake subsystem battery subsystem alternator subsystem internal combustion engine supply rotational input alternator speed torque tracking control systems electric power train developed make sure power train able produce desired throttle torque accelerating vehicle human loop simulation utilized mechanism evaluate effectiveness proposed hybrid electric vehicle proposed simulation used preliminary result identifying capability vehicle terms maximum speed produced vehicle capability alternator recharge battery several tests done simulation namely sudden acceleration acceleration braking test unbounded motion results simulation showed proposed hybrid electric vehicle produce speed reasonable charging rate battery findings study considered terms design optimization implementation real vehicle
extensive research conducted investigate utility agricultural products coir jute bamboo sisal limited life geotextiles llg agricultural products extensive use automotive industry paper industry fishing nets shipping rigs alternative study demonstrates usefulness abundant harmful environment ecotourism bio diversity weed species eichhornia crassipes water hyacinth manufacturing llg biochemical composition cellulose hemicellulose lignin ash content fiber well tensile strength filaments woven geotextiles determined found tensile strength woven geotextiles made higher comparable fibers agricultural products efficacy geotextile short term strength improvement demonstrated comparing cbr value geotextile reinforced soil unreinforced soil cbr values soil reinforced geotextile found higher compared unreinforced soil result obtained study encouraging promoting utility llg road infrastructure projects
aluminum doped zinc oxide azo attained intensive attention good transparent conducting oxide photovoltaic applications work azo films deposited glass substrate radio frequency magnetron sputtering influences substrate temperatures morphological structural optical electrical properties azo films systematically investigated results indicate azo films hexagonal structure axis preferred orientation morphological electrical measurements revealed substrate temperatures strong influence microstructure optical electrical properties azo films azo film highly transparent ultraviolet near infrared range highest average transparency exceeding minimum resistivity low omega carrier concentration mobility high respectively finally performances azo film evaluated practical application cigs photovoltaic device transparent electrode benefited highly transparent conductive feature efficient device reveals efficiency short circuit current density open circuit voltage fill factor standard conditions elsevier rights reserved
behavior soil geosynthetics interfaces depends different properties soil including particle size particle shape density gravimetric water content degree saturation properties geosynthetics include structure texture elements paper pertains study influence particle shape sand behavior sand geotextile interface experiments conducted using conventional sized direct shear box modified interface testing present study two different natural sands one angular particles rounded particles two different geotextiles used results showed particle shape significantly influences interface behavior especially postpeak behavior american society civil engineers
dynamic simulation model micro cogeneration unit based ice internal combustion engine built new component trnsys model considers dynamic processes including start cool overheat protection controls experiment study steady dynamic performances unit presented analyzed calibrating parameters dynamic model model validated experiment data steady dynamic processes improvement prediction accuracy model considering dynamic processes analyzed validation results show dynamic model well predict characteristics unit start cool overheat protection control processes cumulative prediction errors dynamic model decrease increase start stop interval considering dynamic processes qth eta total cumulative prediction errors decreased respectively start stop interval primary energy saving ratio emission reduction ratio increases increase start stop interval start stop interval unit paper longer energy consumption micro cogeneration unit would larger conventional system elsevier ltd rights reserved
importance treatment augmentation important clinical decision pharmacotherapy depression yet studies examined rates treatment augmentation medication class objective aim study examine initial pharmacotherapies depression likely others result subsequent treatment augmentation methods study retrospective cohort analysis administrative data privately insured adults age years diagnosed new episode depression propensity score adjusted logistic regression cox regression used model effect class initial monotherapy treatment augmentation risk adjustors included depression severity comorbidities provider type insurance demographic characteristics exposure class initial monotherapy health care provider type main independent variables interest main outcome outcome augmentation monotherapy results thirty four percent individuals received treatment augmentation compared selective serotonin reuptake inhibitor monotherapy second generation antipsychotics initial treatment associated significant increase likelihood augmentation compared classes hazards ratio confidence interval result corroborated propensity score adjustment odds ratio comparing second generation antipsychotics classes pharmacotherapy significant predictor treatment augmentation provider type mental health specialists likely augment treatment compared generalists hazards ratio conclusions type initial antidepressant therapy associated chances treatment augmentation second generation antipsychotics progressed augmentation rapidly classes
purpose study evaluate locus control loc predicts various quality life qol mental well measures among terminally ill cancer patients time palliative care consult multi site analysis patients advanced cancer seen new patients palliative supportive care outpatient clinic patients completed following surveys locus control loc scale functional assessment chronic illness therapy general fact functional assessment chronic illness therapy spiritual facit hospital anxiety depression scale hads herth hope index hhi regression models created examine effect loc upon qol symptoms measures mental well models adjusted effect age gender race partnership status education months since diagnosis potential confounders study enrolled patients adjusting site race partnership status higher levels loc chance predicted decreased qol fact higher levels loc chance also correlated increased depression anxiety decreased meaning peace faith additionally higher levels loc chance predicted decreased hope hhi terminally ill cancer patients high loc chance may risk decreased physical mental well end life efforts made identify patients design interventions increase feeling control situation order improve physical mental well end life
paper compare numerical simulations experiments droplets impinging onto hot surface temperature well leidenfrost point different impacting weber numbers ranging use novel numerical method simulation two phase flows phase change evaporation boiling accounts heterogeneous thermodynamic conditions liquid gas interface present results experimental numerical values droplet shape spreading diameter loss momentum numerical simulations determine time evolution average vapor layer thickness typically one two orders magnitude smaller initial droplet diameter thermal transfer liquid gas phases also investigated numerically experimentally numerical results like experiments droplet heating increases impacting weber numbers fully resolved direct numerical simulations allow accurate description multi scale complex problem involving fluid mechanics coupled heat mass transfer elsevier ltd rights reserved
introduction alternative lengthening telomeres alt mechanism first observed model organism cerevisiae interestingly mechanism necessary viability tumor cells unfortunately molecular underpinnings yet completely understood objective combine carefully designed non targeted mass spectrometry based metabolomics experiments bioinformatics approach characterize alt positive phenotype observed yeast metabolomics level methods profiled metabolome using mass spectrometry yeast strains lost telomerase expression well pre senescence rescued states dissect unwanted technical variation biologically relevant variation states used two step normalization strategy first empirical bayesian framework next corrected secondorder technical effects results results show alt positive yeast strains present two different types metabolic responses genetically induced telomerase dysfunction systemic specific key difference responses systemic response lasts even yeast strains genetically rescued specific response interestingly metabolic changes associated generic stress responses dna damage well specific responses like accelerated aging early telomerase inactivation conclusions mass spectrometry based metabolomics approach reveals two distinct types metabolomics response telomerase dysfunction yeast identifying changes protein arg arg metabolite datp ddtp amounts complement available information alt genome wide level
presence higher order harmonics causes problems quality efficiency energy supply voltages sinusoidal inverters vsi pulse width modulated pwm asynchronous motors drives widely used industry paper proposes artificial neural network identifies quality sine wave calculates efficiency electric drive system according index modulation sine wave voltage delivered electric motor along inverters modulated devices semiconductors igbts also shown effect efficiency operation harmonic losses
high concentrations cryoprotective agents required cryopreservation techniques vitrification glycerol common cryoprotective agent used cryopreservation protocols agent toxic high concentrations work attempt mitigate toxic effects high concentrations glycerol intact chondrocytes human knee articular cartilage total knee arthroplasty patients simultaneous exposure glycerol variety additive compounds resulting cell viability cartilage samples measured membrane integrity staining showed least one concentration combination tested additive compounds tetramethylpyrazine ascorbic acid chondroitin sulphate glucosamine sulphate able reduce deleterious effects glycerol exposure examination membrane integrity took place delayed time frame use additive compounds reduce cryoprotectant toxicity articular cartilage may help improve cell recovery cryopreservation elsevier inc rights reserved
collagenous sprue rare enteropathy characterized villous atrophy thickened subepithelial collagen band aim study describe cross sectional imaging findings case control retrospective study cases patients january performed inclusion criteria histopathologic diagnosis imaging computed tomography abdomen pelvis enterography cte magnetic resonance enterography within months small bowel biopsy control subjects irritable bowel syndrome ibs patients underwent cte imaging studies examined two radiologists blinded patient data patients ibs included mean age years female group ibs group patients significantly older year likely angiotensin receptor blockers compared ibs group compared ibs patients likely mesenteric lymph node prominence jejunoileal fold pattern reversal dilation conformational change wall thickening ulcerative jejunoileitis radiologists suspected malabsorption group ibs group imaging findings suggestive mucosal malabsorption commonly demonstrated
paper unified solution method presented classical beam theory strength materials approach geometry material properties load system known related unknowns forces moments slopes deformations applying classical differential analysis addition equilibrium constitutive kinematic laws relations expressed unified formulation classical beam theory special case simple beams system four linear ordinary differential equations first order represents general mechanical behaviour straight beam equations solved using numerical differential quadrature method dqm application dqm advantages mathematical consistency conceptual simplicity numerical procedure simple gives clear understanding systematic way obtaining influence line bending moment shear force diagrams deformed shape beams geometric load discontinuities discussed paper buckling loads natural frequencies beam prismatic non prismatic type support conditions evaluated ease
background randomized double blind placebo controlled phase comfort trial evaluated jak jak inhibitor ruxolitinib patients intermediate high risk myelofibrosis primary planned year analyses comfort data demonstrated ruxolitinib first myelofibrosis approved therapy reduced splenomegaly prolonged overall survival versus placebo present final year results methods patients managed australia canada usa randomized centrally interactive voice response system oral ruxolitinib twice daily per baseline platelet counts placebo investigators patients blinded treatment secondary endpoints evaluated analysis durability reduction baseline spleen volume spleen response overall survival evaluated intent treat population safety evaluated patients received study treatment results patients randomized september april ruxolitinib placebo termination ruxolitinib randomized patients crossed placebo treatment patients remained placebo patients randomized ruxolitinib median spleen response duration weeks prolonged median overall survival versus placebo ruxolitinib group reached placebo group weeks despite crossover ruxolitinib ruxolitinib safety profile remained consistent previous analyses common new onset grade nonhematologic adverse events starting months ruxolitinib initiation fatigue diarrhea new onset grade anemia thrombocytopenia primarily occurred within first months cases months common treatment emergent adverse event related deaths ruxolitinib randomized group sepsis disease progression pneumonia conclusion final comfort results continue support ruxolitinib effective treatment patients intermediate high risk
objective aims study reveal nutritional status patients head neck tumour treatment using mini nutritional assessment short form mna analyse factors affecting nutritional status patients head neck tumour background elderly patients loss teeth maxillary mandibular bone due head neck tumour treatment could high risk malnutrition however reports nutritional status patients materials methods forty six participants average age years selected patients visited maxillofacial prosthetics clinic tokyo medical dental university hospital faculty dentistry japan nutritional status evaluated using mna multiple regression analysis used identify predictors affecting mna score candidate explanatory variables age sex maxillofacial prosthesis use number residual teeth resection side neck dissection treatment option results results showed approximately half patients risk malnutrition regression equation mna score developed using two predictors maxillofacial prosthesis use neck dissection conclusion use maxillofacial prosthesis improve nutritional status hand medical history neck dissection decrease nutritional status
purpose paper aim focus design manufacture test stiffened panel composite material integrated longitudinal foam filled stiffeners spar rib caps using one shot liquid infusion process reducing weight number subparts respect metallic reference baseline avanti vertical fin design methodology approach extensive activities computational applications order improve efficiency design process finite element analysis structural sizing codes led optimised engineering design process resulted successful stiffened carbon fibre reinforced polymer panel design terms weight number parts respect metallic baseline findings composite panel fulfilled design requirements reduction mass number parts respect metallic reference baseline overcoming certification static test confirming reliability theoretical analyses research limitations implications composite aircraft components conceived unitized structure one shot process guarantee mass reduction compared aluminium components assure also reduction number subparts assembly process cycle time hand technology implies development specific advanced techniques control manufacturing weight practical implications stiffened panel used component aircraft structures solution shown work find applications many parts aircraft originality value results obtained work useful work aeronautical structural departments aim reduce weight subparts airframe
bipolar disorder unique disorder transcends domains function since patient exhibit depression mania states polar opposite mood symptoms depression people feel helplessness reduced energy risk aversion mania behaviors include grandiosity increased energy less sleep risk preference neural mechanism underlying state gaining clarity catecholaminergic disruption seen mania cholinergic dysfunction depression fact patient cycles switches states defining characteristic however greater importance therefore mechanism underlying cycling one state associated neural changes another considered holy grail research herein review studies investigating triggers induce switching states identifying triggers researchers study neural mechanisms underlying state importantly mechanistic changes occur subject current animal models switch also discussed submissive dominant behaviors kindling effects focus however placed seasonal changes induce manic depressive states sufferers importantly changing photoperiod lengths induce local switches neurotransmitter expression normal animals increased catecholaminergic expression periods high activity increased somatostatin corticotrophin releasing factor periods low activity identifying susceptibilities switch would enable development targeted animal models animal models targeted treatments could developed tested would minimize likelihood switching elsevier rights reserved
sensor networks widely used various domains like intelligent transportation systems users issue queries sensors collect sensing data due low quality sensing devices random link failures sensor data often noisy order increase reliability query results continuous queries often employed work focus continuous holistic queries like median existing approaches mainly designed non holistic queries like average however trivial answer holistic ones due non decomposable property first propose two schemes based data correlation different rounds one getting exact answers one deriving approximate results combine two proposed schemes hybrid approach adaptive data changing speed evaluate design extensive simulations results show approach significantly reduces traffic cost compared previous works maintaining accuracy
background metabolic syndrome mets significantly correlates exercise mets also independent inverse correlation quality life qol however studies examined association exercise qol people mets aim study ascertain relationship exercise qol mets population methods cross sectional study using public data sixth korean national health nutrition examination survey mets defined basis revised national cholesterol education program criteria demographic factors three types exercise resistance flexibility walking five subsets euroqol mobility self care usual activities pain discomfort anxiety depression qol scores vas investigated independent associations exercise five subsets qol determined using odds ratios adjusted four demographic factors age group sex weight change area residence using multivariate logistic regression analysis results prevalence mets ratio subjects performing resistance flexibility walking exercise among population respectively vas exercisers significantly higher non exercisers resistance flexibility walking exercise although resistance flexibility exercise correlate subsets qol mobility self care significantly associated walking exercise respectively conclusions exercisers showed higher qol scores non exercisers among qol subsets mobility self care independently associated walking exercise mets population regular walking exercise important higher qol mets first clinical report indicate qol could independently influenced walking exercise
paper presents practical tool articulating best value criteria procurement public sector building projects korea data obtained sampling stakeholders drawn mainly pool government construction project management experts republic korea analytical hierarchy process ahp employed rank emergent value criteria study finds best value judgments multi faceted assessments stakeholder needs mitigated project characteristics span functional aesthetic considerations american society civil engineers
image splicing common widespread type manipulation defined pasting portion image onto second image several forensic methods developed detect splicing using various image properties methods exploit noise statistics image try find discrepancies paper propose new counter forensic approach eliminate noise differences appear spliced image approach also used creating computer graphics images order endow realistic noise performed changing noise statistics spliced elements closer original image proposed method makes use novel way transfer density functions apply image noise order impose identical noise density functions source destination image method used arbitrary noise distributions method tested several noise based splicing detection methods order prove efficacy
recent years international trend towards installing rainwater tanks attempt save water study investigates possibility simplifying process sizing rainwater tank optimal results constant water demand required size rainwater tank influenced mean annual precipitation size roof used harvesting water demand desired certainty supply rainfall patterns study investigates use generalised equation form runoff parameter storage parameter constants differ location depending rainfall characteristics results obtained using generalised equation compared results obtained simulating tank behaviour year period three rainfall stations results suggest equation used estimate storage capacity rainwater tank
arrays sharp conical spike microstructures created repeatedly irradiating silicon surfaces focused femtosecond laser pulses absorbance light increased approximately wavelength range near ultraviolet near infrared microstructured silicon surface microstructured surface presents pitch black enhanced absorption broad wavelength range called black silicon unique microstructure morphology black silicon surface formed femtosecond laser also bring lot surface functions example self cleaning field emission functions make black silicon highly desirable solar energy detectors fields therefore forming mechanism conditions fabrication optimization black silicon microstructure always focus research work sample moved motor controlled stage laser beam fixed case laser beam scanning arrays sharp conical spikes silicon manufactured kpa aim experiment find optimize distribution laser energy number laser accumulation pulses combination single pulse energy pulse number control surface morphology black silicon experimental results show appears bottleneck effect morphology size growth increase laser irradiation improving single pulse energy increasing pulse accumulation number excessive energy accumulation brings extra effect optimizing controlling microstructure morphology surface based theoretical results obtained physical model proposed find reason phenomenon microstructure morphology induced former sequence pulse modulates laser energy absorption current laser pulse changes laser ablation efficiency current pulse according physical mechanism propose new way optimizing surface morphology fixing total laser irradiation energy size distribution surface morphology achieved optimizing distribution laser energy number laser accumulation pulses approach improve efficiency silicon surface preparation microstructures also reduce surface defects damage furthermore proposed method reduce energy consumption process femtosecond machining great significance engineering application black silicon
myeloproliferative neoplasms mpns clonal disorders characterized increased production mature blood cells philadelphia chromosome negative mpns mpns consist polycythemia vera essential thrombocythemia primary myelofibrosis pmf number stem cell derived mutations identified past years findings showed jakvf diagnostic marker involving jak exon high frequency best molecular characterization mpns somatic mutations endoplasmic reticulum chaperone named calreticulin calr second common mutation patients pmf jak mutation discovery calr mutations led increased molecular diagnostic pmf shown jakvf unique event disease pathogenesis genes location tet oncogene family member tet additional sex combs like asxl casitas lineage lymphoma proto oncogene cbl isocitrate dehydrogenase idh idh ikaros family zinc finger ikzf dna methyltransferase dnmta suppressor cytokine signaling socs enhancer zeste homolog ezh tumor protein runt related transcription factor runx high mobility group hook hmga also identified involved mpns phenotypes current molecular biology genetic mechanisms involved mnps focus aforementioned factors presented elsevier ireland ltd rights reserved
micro small scale thermoelectric generation modules able produce continuous noise free reliable electricity power using low temperature differences widely exist nature industry advantages bring great application prospects fields remote monitoring microelectronics micro electromechanical systems mems medical apparatus smart management system often require power source free maintenance vibration work prototypical thermoelectric module pairs micro scale thermoelectric legs width height leg fabricated using low cost mechanical machining process process cutting polishing main methods preparation thermoelectric pairs commercial polycrystalline materials fabrication electrode patterns fabricated module tested power generation properties hot side heated electrical heater cold side cold air heater temperature thermoelectric potential short circuit current maximum output power finite element method applied analyze heat transfer module test temperature difference heat flux simulated according output powers different temperatures calculated result relatively consistent compared test results
rainwater harvesting rwh potential reduce water related costs providing alternate source water addition relieving pressure public water sources reducing stormwater runoff existing methods determining optimal size cistern component rwh system various drawbacks specificity particular region dependence numerical optimization failure consider costs system paper formulation developed optimal cistern volume incorporates fixed distributed costs rwh system also taking account random nature depth timing rainfall focus rwh supply domestic nonpotable uses rainfall inputs modeled marked poisson process comparing costs associated building cistern costs externally supplied water expression optimal cistern volume found minimizes water related costs volume function roof area water use rate climate parameters costs cistern external water source analytically tractable expression makes clear dependence optimal volume input parameters analysis rainfall partitioning also characterizes efficiency particular rwh system configuration potential runoff reduction results compared rwh system duke smart home durham usa show method could used practice elsevier rights reserved
research development ideal dental composite still ongoing focused filler content polymerization silica important filler used several commercial dental composites present silica used fabrication dental composites synthesized classic sol gel method using toxic expensive precursors chemicals rice husk abundant source silica malaysia major rice producing country study aimed extracting spherical nanosilica rice husk using environment friendly inexpensive method inclusion fillers dental nanocomposites spherical nanosilica extracted rice husk using simple precipitation method employing non toxic chemicals dental nanocomposite thus prepared subjected flexural strength modulus tests important tests predicting strength materials flexural strength dental composite mpa modulus gpa results indicate rice husk agricultural waste good inexpensive source silica used fillers fabrication dental nanocomposites good mechanical properties
children exposed animated cartoons early age gender class race related messages likely influential development children beliefs attitudes gender roles class racial groups although representations females minority children animated cartoons improved years stereotypical racially biased portrayals females racial minority groups remain using intersectionality theoretical lens textual analysis conducted examine representation two current leading minority female characters children animated cartoons doc mcstuffins dora explorer character portrayals stereotypes challenges traditional stereotypes intersecting role race gender class representations characters explored analysis
paper analyzes first stability single loop digital voltage control scheme filtered voltage source inverters turns phase lag caused time delay digital control system use integral controller stabilize voltage loop without damping filter resonance stability regions identified alternative voltage controller synthesized widening stability region active damping approach proposed designed voltage controller discrete domain simulations experimental results systems validate theoretical analyses performance approach
vehicular emissions significantly increase atmospheric air pollution greenhouse effect fact associated fast growth global motor vehicle fleet demands technological solutions scientific community order achieve decrease fuel consumption emission especially fossil fuels comply future legislation meet goal prototype stratified torch ignition engine designed commercial baseline engine system combustion starts pre combustion chamber pressure increase pushes combustion jet flames calibrated nozzle precisely targeted main chamber combustion jet flames endowed high thermal kinetic energy able promote stable lean combustion process high kinetic thermal energy combustion jet flame results load stratification carried direct fuel injection pre combustion chamber means prototype gasoline direct injector gdi developed low fuel flow rate compression stroke lean mixture coming main chamber forced pre combustion chamber degrees spark timing fuel injected pre combustion chamber aiming forming slightly rich mixture cloud around spark plug suitable ignition kernel development performance torch ignition engine running presented different mixture stratification levels engine speed load performance data combustion phasing specific fuel consumption thermal efficiency specific emissions carefully analyzed discussed paper results obtained work show significant increase torch ignition engine performance comparison baseline engine used workhorse prototype engine construction elsevier ltd rights reserved
amygdala known key brain region involved explicit implicit processing emotional faces plays crucial role salience detection recently mismatch negativity mmn component event related potentials odd stimulus sequence stimuli utilized index preattentive salience detection emotional voice processing however relationship remains delineated study combined fmri scanning event related potential recording examining amygdala reactivity response explicit implicit backward masked perception fearful angry faces along recording mmn response fearfully angrily spoken syllables dada healthy subjects varied trait anxiety stai results indicated amplitudes fearful mmn positively correlated left amygdala reactivity explicit perception fear negatively correlated right amygdala reactivity implicit perception fear fearful mmn predicted stai along left amygdala reactivity explicit fear whereas association fearful mmn stai mediated right amygdala reactivity implicit fear findings suggest amygdala reactivity response explicit implicit threatening faces exhibits opposite associations emotional mmn terms emotional processing mmn reflects preattentive saliency detection also stands crossroads explicit implicit perception hum brain mapp wiley periodicals inc
introduction overactive bladder oab accounts cases incontinence etiology unknown though detrusor instability found urodynamic evaluation almost cases detrusor instability hyperreflexia inhibited direct inhibition impulses pre ganglionic afferent neuron inhibition bladder pre ganglionic neurons efferent limb micturition reflex transcutaneous electrical nerve stimulation tens based gate control theory abolishing local micturition reflex arc aim assess effectiveness safety tens idiopathic oab materials methods prospective experimental study evaluate effectiveness tens placebo reducing oab symptoms ten treatment sessions sessions week minutes conducted results significant improvement overactive bladder symptom scores oabss tens group patients completely dry following tens therapy conclusion elderly women patients oab medications anticholinergic side effects impairment cognition concern tens useful intervention tens units safe economical easily commercially available
rapid vehicle powertrain development become essential design implementation vehicles meet exceed fuel efficiency cost performance targets expected today consumer keeping pace reduced development cycle frequent product releases recently advances large scale additive manufacturing provided means bridge hardware loop hil experimentation preproduction mule chassis evaluation paper details accelerated development printed range extended electric vehicle reev oak ridge national laboratory paralleling hardware loop development powertrain rapid chassis prototyping using big area additive manufacturing baam baam ability accelerate mule vehicle development computer aided design vehicle build explored use hardware loop laboratory described applied design range extended electric powertrain installed printed prototype vehicle integration powertrain opportunities challenges presents described work comparison offline simulation hil chassis rolls results presented validate development process chassis dynamometer results battery electric range extender operation analyzed show benefits architecture authors published elsevier ltd open access article license http creativecommons orgflicenses
widespread adoption combined heat power generation widely recognized strategic goal achieve significant primary energy savings lower carbon dioxide emissions context purpose research evaluate potential cogeneration based reciprocating gas engines italian hospital buildings comparative analyses conducted based load profiles two specific hospital facilities study cogeneration system user interaction end specific methodology set coupling specifically developed calculation algorithm genetic optimization algorithm multi objective approach adopted results optimization problem highlight clear trade total primary energy savings tpes simple payback period spb optimized plant configurations management strategies show tpes exceeding reference hospital facilities multi gas engine solutions along minimum spb approximately three years thereby justifying european regulation promoting cogeneration however designing chp plant specific energetic legislative market scenario guarantee good performance scenarios change reason proposed methodology enhanced order focus innovative aspects particular study proposes uncommon effective approach identify stable plant solutions multi objective robust design optimization particular sensitivity expected results possible difficulties finding commercially available chp gas engines sizes reasonably close optimal numerical solutions estimated results indicate economic sensitivity often higher energetic sensitivity optimal solutions standard deviation accounting mean value spb whereas percentage always tpes furthermore research highlights expected results obtained deterministic definition input decision variables could overestimated compared robust design approach proposed research also highlights optimized chp plants characterized reasonable levels energetic economic sensitivity changes following variable quantities selling price electricity reference efficiency italian thermoelectric generation selling price energy efficiency certificates recognized italian legislation indeed pareto optimal solutions indicate standard deviation spb always less mean value percentage always tpes elsevier ltd rights reserved
study linked research narrative persuasion techniques used reduce rejection stigmatized groups upper secondary school students assigned one two conditions viewing film arouses empathy toward immigrants seeing film underscores positive intergroup contact one month viewing films participants completed modern racism scale viewed films researchers measured identification ingroup outgroup characters attitudes toward immigration results showed viewing empathyarousing film caused greater identification outgroup characters turn induced positive attitudes toward immigration previous prejudice low moderate discuss findings context narrative persuasion research
although prevalence food causes asthma well known food allergy implicated variety respiratory symptoms eighty two asthmatic children aged years doctor diagnosed sensitization inhalants presenting asthma exacerbation participated study food allergies linked asthma exacerbations diagnosis food allergy established using questionnaire clinical criteria serum specific ige antibody measurements atopy patch test asthma exacerbation determined using fractional exhaled nitric oxide management children admitted hospital basis questionnaire data suspected food allergy identified children positive negative rates serum food specific ige tests respectively results atopy patch tests radioallergosorbent positive participants positive negative food allergy risk factor asthma exacerbation evaluation food allergy selected patients asthma indicated
aim study improve thermal stability mechanical surface properties bisphenol dicyanate ester badcy addition bisphenol dicyanate ester bpdcy colemanite cyanate esters badcy bpdcy prepared diphenol compound bisphenol bisphenol cyanogen bromide presence triethylamine chemical structure synthesized cyanate esters investigated fourier transform infrared spectroscopy nuclear magnetic resonance spectroscopy nmr nmr techniques cyanate esters colemanite composites various ratios badcy bpdcy colemanite prepared thermal stability samples evaluated thermogravimetric analysis differential scanning calorimetry samples characterized following analyses gel content water absorption capacity stress strain test hydrophobicity samples determined contact angle measurements moreover surface morphology samples investigated scanning electron microscopy energy dispersive spectrometer mapping finally obtained results prove prepared composites good thermal mechanical surface properties used many applications electronic devices materials engineering emergent
glutamate principal excitatory neurotransmitter central nervous system actions related behavioral effects psychostimulant drugs last two decades basic neuroscience research preclinical studies animal models suggesting critical role glutamate transmission drug reward reinforcement relapse although interest centered post synaptic glutamate receptors presynaptic synthesis glutamate brain glutaminases may also contribute imbalances glutamate homeostasis key feature glutamatergic hypothesis addiction glutaminases main glutamate producing enzymes brain dysregulation function associated neurodegenerative diseases neurological disorders however possible implication enzymes drug addiction remains largely unknown mini review focuses brain glutaminase isozymes alterations vivo exposure drugs abuse discussed context glutamate homeostasis theory addiction recent findings mouse models shown drugs induce changes expression profiles key glutamatergic transmission genes although molecular mechanisms regulate drug induced neuronal sensitization behavioral plasticity clear
paper proposes torque control strategy charge battery parallel hybrid electric vehicles hevs charge torque internal combustion engine ice newly introduced previous paper regenerative braking used charge battery however sufficient nox emissions reduction thus effective energy management system ems developed maintain battery state charge soc target soc also introduced charge torque addition charge driving condition charge torque ice generated newly proposed introducing charge driving ice driving region torque engine speed plane reduced result greater reduction nox emissions expected based ems proposed previous papers ems incorporating charge driving developed typical driving cycles validity proposed ems algorithm incorporating charge driving examined
family increasingly recognised pivotal migration remain studies examining migration impacts intergenerational relationships although traditional intergenerational gaps intensified migration arguably emphasis divisions traditional parents modern children expense examining ways generations adapt foner dreby relations generations immigrant families annual review sociology stress reality post migration intergenerational relations inevitably complex requiring examination conflict cooperation article contributes growing literature discussing british data comparative projects intergenerational relations african families britain france south africa argues particular understandings gained examining adaptation parents parenting strategies post migration reconfiguration family relations contribute settlement focusing parent child generations engage conflict negotiation redefine relationships expectations offers insight families navigate integrate values two cultures argues reconfiguration gender roles result migration offers families space renegotiate relationships make choices transmit next generation
previous studies shown asymmetries upper limb sensorimotor function dependent source sensory motor information hand preference differences hand strength utilization sensory motor information mode control force may differ right hand left hemisphere left hand right hemisphere systems clearly understand unique contribution hand strength intrinsic differences control grasp force investigated hand hemisphere differences source force information encoded two different force levels corresponding maximum voluntary contraction right left hand participant eleven adult males demonstrated stronger right left maximum grasp force requested match right left hand maximal voluntary contraction reference force opposite hand matching task visual feedback corresponding production reference force available removed contralateral hand performed match matching relative force error significantly different hands mvc reference force mvc reference force directional asymmetries quantified matching force constant error showed right hand overshoots left undershoots force dependent primarily due greater undershoots matching left hand right hand reference force findings suggest interaction internal sources information efferent copy proprioception well hand strength differences appear hand hemisphere system dependent investigations force matching tasks conditions whereby force level varied visual feedback reference force available provides critical baseline information building effective interventions asymmetric stroke related parkinson disease symmetric amyotrophic lateral sclerosis upper limb recovery neurological conditions various sources sensory motor information significantly altered disease process
video oculography vog tool providing diagnostic information progress diseases cause regression vergence eye movements parkinson disease majority existing systems based sophisticated infra red devices study authors show webcam based vog system provide similar accuracy head mounted based vog system also prove authors iris localisation algorithm outperforms current state art methods popular bioid dataset terms accuracy proposed system consists set image processing algorithms face detection facial features localisation iris localisation performed examinations patients suffering using system jazz novo head mounted device sensor reference experiments obtained mean correlation results method jazz novo shown accuracy visual system similar accuracy head mounted devices future plan extend experiments inexpensive high frame rate cameras potentially provide diagnostic parameters
background common problem information technology courses difficulty providing practical exercises although different approaches followed solve problem still open issue specially security computer network courses results paper proposes netinvm tool based nested virtualization includes fully functional lab comprising several computers networks single virtual machine also analyzes evaluates used different teaching environments conclusions results show tool makes possible perform demos labs practical exercises greatly appreciated students would otherwise unfeasible also portability allows reproduce classroom activities well students autonomous work
purpose transcranial magnetic stimulation tms neurophysiological technique long established pedigree safety tolerability efficacy initially tms used study function cerebral cortex become treatment migraine one common debilitating neurological conditions review discuss scientific background development technique explore application treatment migraine ponder possible mechanisms action common neurological condition overview generation brief magnetic pulses suitable coil induce electrical fields body applied cerebral cortex currents painlessly induced cortical neurons currents lead neuronal depolarization may influence cortical excitability means yet fully understood ability modulate cortical excitability exploited treatment migraine aura aura implicated pathophysiology migraine experimental studies shown transcranial magnetic pulses block waves cortical spreading depression experimental equivalent migrainous aura discussion migraine debilitating condition characterized headache nausea sensory hypersensitivity may affect population yet current drug treatments often poorly tolerated clinical studies shown tms effective treatment migraine addition added advantages safe well tolerated patients
background rates smoking among pregnant women west virginia higher national prenatal smoking rates recent research pointed benefit smoking reduction among sample pregnant women participated clinical study west virginia purpose current study examine trends associated reduced smoking exposure among representative sample pregnant women state method secondary data analysis conducted using identified weighted prams data west virginia examining factors associated favorable change prenatal smoking behavior either quitting reducing smoking pregnancy results multivariable analyses results demonstrate pregnant women likely engage favorable smoking behavior change younger years age primiparous higher level education discussion findings study identified factors contribute women likelihood quitting reducing smoking pregnancy west virginia health care providers policy makers consider factors implementing approaches effective promoting smoking cessation reduction among pregnant women state thereby reducing prenatal smoking exposure conclusion population based research used identify factors associated smoking cessation reduction used develop appropriate effective approaches modifying health behaviors specific populations
main purpose paper study common sports injury tennis teaching training conducted survey analysis research object using method literature questionnaire survey interview mathematical statistics research methods results show damage reason common areas characteristics tennis experimental data gathered compared end paper study tennis sports injury prevention measures summarize study
ary cube one attractive interconnection networks parallel distributed computing systems paper investigate hamiltonian cycle path embeddings ary cubes based structure faults means faulty element isomorphic connected subgraph connected graph let connected graph show two arbitrary distinct healthy nodes faulty exists fault free hamiltonian path connecting two nodes number faulty element certain number faulty element isomorphic connected subgraph also show exists fault free hamiltonian cycle number faulty element certain number faulty element isomorphic connected subgraph results mean ary cube tolerate faulty nodes still hamiltonian hamiltonian connected denotes faulty set
lower urinary tract lut health regulated coordinated multi level neurological inputs require intact central peripheral nervous system lower urinary tract dysfunction therefore common sequelae neurological disease patterns bladder storage voiding dysfunction depend upon level neurological lesion evaluation includes history taking bladder diary urological examination relevant ultrasonography urodynamic testing indicated antimuscarinic agents first line treatment patients storage dysfunction alternative treatments include intradetrusor injection onabotulinumtoxina shown benefit patients neurogenic detrusor overactivity ndo neuromodulation intermittent catheterization remains option choice patients significant voiding dysfunction resulting high post void residual volumes
background atypical hyperplasia mammographic breast density mbd established risk factors breast cancer joint contributions well understood examine associations mbd histologic impression including subcohort women mayo clinic benign breast disease cohort methods women diagnosis bbd mammogram eligible histologic impression assessed via pathology review coded non proliferative disease proliferative disease without atypia pdwa mbd assessed clinically using parenchymal pattern rads criteria categorized low moderate high percent density also available subset women clinical information obtained questionnaires medical records mayo clinic tumor registry women followed date benign biopsy death last contact standardized incidence ratios sirs compared observed number bcs expected counts cox regression estimated multivariate adjusted mbd hazard ratios results women included study low mbd moderate mbd high mbd total women pdwa median follow years bcs observed association mbd risk differed histologic impression interaction strong mbd association among demonstrated marginal evidence increased risk sir results statistically significant conclusion found evidence association mbd subsequent risk women
paper studies use fuzzy proportional integral derivative pid controller based genetic algorithm docking maneuver two spacecraft space environment docking maneuver consists two parts translation orientation derive governing equations translational phase hill linear equations local vertical local horizontal lvlh frame used fuzzy pid fpid controller design two fuzzy inference motors utilized single input fuzzy inference motor sifim first one input state variable separate sifim defined another fuzzy inference motor preferrer fuzzy inference motor pfim represents control priority order state variable supervisory role large deviations fpid controller covers servicer translation docking maneuver tries dock stable nonrotating target various conflicting objective functions distance errors set point control efforts enter control limit optimization problem maximal value thrust force constrained considering objective functions statistical analysis parameters performed test best minimum fuel consumption minimum deviations servicer equilibrium point chosen best test three dimensional pareto frontiers corresponding best test plotted optimal points related objective functions demonstrated time response figures corresponding points generated results prove controller shows efficient performance docking maneuver servicer spacecraft comparison similar work number system performance parameters settling time improved overshoot critical parameter docking maneuver truncated american society civil engineers
optically based sensing system measure displacement strain essentially entire area utility scale blade leads measurement system significantly reduce time cost associated traditional instrumentation paper evaluates performance conventional three dimensional digital image correlation dic three dimensional point tracking dpt approaches surface wind turbine blades proposes multi camera measurement system using dynamic spatial data stitching potential advantages proposed approach include full field measurement distributed large area elimination time consuming wiring expensive sensors need large channel data acquisition systems several challenges associated extending capability standard dic system measure entire surface utility scale blades extract distributed strain deflection modal parameters paper tries address difficulties including assessing accuracy dic system measure full field distributed strain displacement large area understanding geometrical constraints associated wind turbine testing facility lighting working distance speckle pattern size evaluating performance dynamic stitching method combine two different fields view extracting modal parameters aligned point clouds determining feasibility employing output system identification estimate modal parameters utility scale wind turbine blade optically measured data within current work results optical measurement one stereo vision system performed large area utility scale blade subjected quasi static cyclic loading presented blade certification testing typically performed using international electro technical commission standard iec static tests blade pulled either flap wise edge wise directions measure deflection distributed strain limited locations large sized blade additionally paper explores error associated using multi camera system two stereo vision systems measuring displacement extracting structural dynamic parameters mock set emulating utility scale wind turbine blade results obtained paper reveal multi camera measurement system potential identify dynamic characteristics large structure elsevier ltd rights reserved
psychiatric disorders particular depression increased great recession aim study investigate consumption psychotropic drugs people lost permanent employment using administrative data study considered subjects domiciled lombardy northern italy lost permanent employment assuming psychotropic drugs find new job within following months control group included people lose permanent job study period matched cases gender age nationality skill level education economic sector using propensity score matching subjects lost permanent employment likely receive one drug prescriptions controls difference significant males females subjects aged years low skill level workers italians likely received prescription psychotropic drugs respectively males subjects aged years aged years low skill level workers non italians average number drugs prescribed lost job continued working respectively conclusion losing permanent job increases significantly psychotropic drugs consumption males females
study examined preferences masculinity across faces bodies personality traits homosexual bisexual men china impact sexual self labels tops bottoms versatiles attitude toward male masculinity preferences masculinity also examined participants asked select seven desirable personality traits romantic partner list traits gender roles series masculinized feminized dimorphic images male faces bodies presented participants required identify preferred image results indicated participants preferred masculine faces bodies personality traits significant differences preferences masculinity found tops bottoms versatiles bottoms versatiles preferring masculine faces bodies personality traits tops addition preferences masculinity across faces bodies traits showed significant positive correlation sexual self labels indicating consistent preference masculinity attitude toward male masculinity significantly correlated facial body trait preferences individuals rigid attitudes toward male masculinity low acceptance femininity males preferred masculine characters results indicate consistent preference masculinity physical features faces bodies personality traits instrumentality may affected observer perception
generation migration differentiation neurons requires functional integrity micro tubule cytoskeleton mutations tubulin gene family known cause various neurological diseases including lissencephaly ocular motor disorders polymicrogyria amyotrophic lateral sclerosis previously reported mutations tubb cause microcephaly accompanied severe intellectual impairment motor delay present characterization tubb mouse model allows conditional expression pathogenic mutation homozygous knockin animals exhibit severe reduction brain size body weight animals show significant impairment general activity anxiety acoustic startle response however present notable defects motor coordination assessed static rod apparatus mice took longer orient often lost balance completely interestingly mutant animals also showed defects pre pulse inhibition phenotype associated sensorimotor gating considered endophenotype schizophrenia study provides insight behavioral consequences tubulin gene mutations authors published elsevier
colour detection plays important role many computer vision based applications however existing colour detection methods tend environment dependent since slight changes environmental factors illumination shadowing effects could greatly reduce performances paper new colour model introduced allow enhanced colour detection images even significantly different lighting conditions image qualities proposed colour model called hpbr colour model converted rgb colour model consists three colour components namely hue purity brightness colour model represented three different geometric shapes diamond sphere cylinder assess effectiveness model two different colour detection methods applied onto benchmark images experimental results methods confirmed proposed colour model produced best colour detection results among existing models
subject analysis real process continuous extrusion copper section conform machine prechamber machine operated kamensk uralsky non ferrous metal working plant perlin method used involves determining total pressing force calculate following stability critical parameters conform process length split container frictional force movable surface sufficient extruding metal prechamber die hole wheel torque power electric motor comparing calculated measured data shows discrepancy less derived equations simple easy use technical technological design conform process prechamber exactly purpose study
aging associated alterations composition diversity functional features intestinal microbiota well described modern literature suggested caused age related decline immune system functioning immunosenescence low grade chronic inflammation inflammaging accompany many aging associated pathologies microbiota targeted dietary probiotic interventions shown favorably affect host health aging enhancement antioxidant activity improving immune homeostasis suppression chronic inflammation regulation fat deposition metabolism prevention insulin resistance recently high effectiveness safety novel therapeutic application fecal microbiota transplantation prevention treatment age related pathological conditions including atherosclerosis type diabetes parkinson disease demonstrated review recent research findings summarized role gut micribiota aging processes emphasis therapeutic potential microbiome targeted interventions anti aging medicine elsevier rights reserved
background study carried order explore effect growing appearance ipv television news items deaths cause methods ecological study based deaths intimate partner violence ipv television news items covering topic spanish television channels logistic regression analysis carried dependent variable difference number ipv deaths days following news item broadcast number ipv deaths days media item outcome variable conceptualised binary variable increase increase independent variables days ipv news items general concerning deaths measures ipv crimes adjusted variables day week month year public holidays results small copycat effect observed ipv murder rate ipv related news item days compared days without news effect continued information deaths broadcast news items concerning measures ipv crimes related lower possibility increase deaths compared days death related news conclusion given results observed case ipv related news evident need develop journalistic style guide order determine type information recommended due potential positive negative effects
paper presents initiative seeks develop skills visualization using capabilities programming graphical representation computer algebra system case mathematica specific procedure developed allow engineering students represent families curves obtained cutting graph two variable function families planes different orientations initiative achieves improvement use contour plots shows new point view functions depend angle extended used nonplanar surfaces
paper describes controller design dfig based wind energy generation system using static output feedback technique lmi toolbox features dfig converters controllers discussed lower order nominal representation dfig obtained using numerical differentiation simulink model subsequently used pid controller design obtained results compared existing methods performance enhancement dfig wind energy conversion systems
aiming reduce losses shipwreck paper employs methods mathematics simulation fields build progressive search model give targeted solutions stage simplifying actual process search rescue based air france flight case data put forward two kinds search algorithms conduct optimize maritime search scheme order compare different sea search arrangements using monte carlo simulation analyzing different types search planes best choice set get target way assign different search area resorts sigma principle identifying arrangement find wreckage site quickly meanwhile hour golden window also considered taking factors consideration eventually best algorithm attained maritime search scheme
background adults years older common age group diagnosed cancer however little known beliefs representations regarding treatment related symptoms make decisions manage symptoms home objective aim study explore symptom representation treatment related symptoms older adults cancer methods total older adults treatment cancer completed standardized measure symptom representation demographic patient variables also collected analysis variance tests pearson correlations used analysis results fatigue common noted symptom however several noted symptoms common overall older adults believed symptoms caused either cancer treatment unsure symptoms would last long time able recognize symptom consequences unsure ability control symptoms adults reported comorbid illnesses higher number symptoms believed treatment related symptoms higher consequences conclusions findings suggest older adults experience symptom related consequences question impact actions symptom severity may contribute older adult lack active symptom self management implications practice patient education strategies need address representations new interventions may need developed reinforce symptom consequences empower older adults self manage symptoms
detention ponds one type stormwater best management practices bmps used quantity control stormwater pond works reducing peak discharge downstream temporary storage gradual release paper new experimental procedure using particle image velocimetry piv introduced two dimensional study hydrodynamic behavior fine particles specially designed sediment basin hydrodynamic behavior fine particles different hydraulics parameters achieved shifting outlet placement using different particle size diameters varying distance inlet water surface varying flow rate inlet outlet level reduced fine particle dispersion lower flow rate assisted controlling high siltation furthermore smaller spherical particles influence fine particle suspension therefore controlling hydraulic parameters decrease siltation problem level
report case migrated essure permanent birth control device correct diagnosis made conventional two dimensional three dimensional pelvic sonography years placement device patient presented persistent right sided pain month post placement hysterosalpingogram shown appropriately occluded right fallopian tube overlooked abnormal position right essure device proximal extending slightly uterine cavity wiley periodicals inc clin ultrasound
article analyzed produced discourses violence public schools local newspaper liberal speech used theoretical methodological reference interdisciplinary character passing studies media violence schools elementary base speech ideas michel foucault statements used theoretical methodological referential speech analysis since makes possible observe historical constructions ideological presents speech considering linguistic materiality well exteriority conditions historical social ideological basing approach imaginary understand concrete character symbolic representations heroes villains determined certain occurrences become reference group routine school suffers changes according thought participates imaginary one
climate models predict drying mediterranean summer one way plant species persist climate changes acclimation determine extent trait plasticity response drought differs species sites address question whether trade drought survival phenotypic plasticity throughout summer measured physiological traits photosynthesis max stomatal conductance transpiration leaf water potential structural traits specific leaf area sla leaf density leaf dry matter content ldmc leaf relative water content lrwc leaves eight woody species two sites slightly different microclimate north versus south facing slopes southern spain plant recovery survival estimated summer drought period found high trait variability species variables phenotypic plasticity lower drier site phenotypic plasticity sla ldmc correlated negatively drought survival suggests trade hand high phenotypic plasticity sla ldmc positively related traits associated rapid recovery growth drought period although phenotypic plasticity generally seen favourable stress conditions seemed beneficial favourable conditions propose environments fluctuating drought periods trade drought survival growth favourable conditions climate become drier species high drought survival low phenotypic plasticity might selected
aims study explored sex specific associations friendship trust psychological well young swedes late adolescence early adulthood methods random sample native swedes born surveyed age years age years regarding well relationships maximum five self named peers response rate resulting cases analysed used sex stratified structural equation models explore associations trust well psychological well constructed latent variable measurement part structural part accounted autocorrelation trust respect well time incorporated cross lagged effects late adolescence early adulthood results found trust increased well decreased young men remained stable young women years age young women reported lower well time points whereas sex difference found trust based model fit comparisons simple model without forward reward causation accepted young men whereas reversed causation well trust suggested young women subsequent analysis based assumptions confirmed reversed effect young women conclusions findings suggest young people benefit trustful social relations extent adult populations young women express impaired well run greater risk members networks characterized low friendship trust time
objective several registries already evaluated retention anti tnf therapy psoriatic arthritis psa sometimes reach divergent conclusions study therefore sought assess therapeutic retention rates predictive factors response patient cohort auvergne france followed routine clinical practice methods medical records psa patients treated may analysed psa diagnosis established based caspar criteria results total patients analysed comprising men years women mean psa evolution years common forms peripheral mixed psa anti tnf treatment initiated etanercept cases adalimumab infliximab golimumab six cases anti tnf associated methotrexate mtx overall median duration anti tnf retention months hazard ratios treatment cessation significantly differ etanercept monoclonal antibody groups years approximately etanercept patients monoclonal antibody patients adalimumab infliximab still treated combining mtx prolong overall retention rate tobacco use predictive discontinuation conclusion study demonstrates good anti tnf treatment retention psa patients well confirming deleterious effect smoking providing argument favour combined treatment mtx improve maintenance
background atopic dermatitis inflammatory chronically relapsing intensively pruritic skin disease affect global population angelicae dahuricae radix adr reported anti inflammatory korean medicine present study investigated whether adr suppresses progression animal model methods induced dinitrochlorobenzene dncb adr orally administered mice study effect adr histological analysis immunohistochemistry blood analysis pcr elisa assay performed results adr significantly suppressed like symptoms balb mice adr decreased skin thickness spleen weight mice adr reduced infiltration mast cells inflammatory cells cells mouse skin adr lowered number wbcs blood mice adr reduced levels ige mice serum adr regulated mrna expression tnf alpha mouse skin tissue conclusion present study clearly indicates adr suppresses progression induced dncb balb mice suggests adr might useful drug treatment
background taxanes increasingly used oncology myalgia arthralgia syndrome represents adverse effect drugs becoming common nevertheless information regarding predisposing factors prevention therapy syndrome still lacking patients methods women received docetaxel part fec regimen adjuvant treatment breast cancer retrospectively identified records oncology department data demographics disease specifics adverse effects treatment reviewed patients divided two groups developed docetaxel treatment develop syndrome two groups compared identify risk factors effectiveness drugs used evaluated results sixty seven patients identified fulfilling inclusion criteria nineteen patients developed first docetaxel administration forty eight patients develop syndrome three patients group excluded taking gabapentin pregabalin time docetaxel administration another indication remaining patients constituted control group two groups similar age menopause status stage cancer histology group higher median body surface area likely receive less three intended cycles docetaxel nonsteroidal anti inflammatory drugs atypical antiepileptics extended corticosteroids opioids drugs used treatments conclusion docetaxel associated adverse effect causing incomplete drug treatment possible risk factors effectiveness treatments syndrome presented
sleep ubiquitous phenomenon developmental product subjected vicissitudes human behavior culture author attempt elaborate sleep sleep disorders sleep medicine korea various developmental perspectives personal national scientific korea rapidly developing industrialized nation experiencing immense cultural changes force individuals change behavior value systems example shift working becoming increasingly popular early working hours adopted companies measure win competitions international market clinical setting observed easily patients develop maintain disturbed sleep wake rhythm consequences obstructive sleep apnea presumably due obesity observed studied sleep clinics nuclear family system inevitable outcome industrialization produces profound difference sleeping arrangement children earlier separation parental grandparental sleeping environment question industrialization related changes may affect incidence manifestation sleep sleep disorders background emerging interest healthy sleep sleep disorders exemplified increasing coverage topics mass media publication business development sleep medicine research per also involves developmental perspective interests sleep sleep disorders began sporadically decades ago korea actively organized mainly korean association sleep medicine psychophysiology unified developing force understanding sleep sleep disorders complete without depth understanding culture philosophy tradition developmental perspectives traditional ideas wisdom past unavoidable resources understanding sleep developing sleep researches medicine korea well asia
article provides conceptual framework studying effects religion consumer behavior goal stimulating future research intersection two topics delineate religion multidimensional construct propose religion affects consumer psychology behavior four dimensions beliefs rituals values community dimension religion offer definitions measures integrate previous findings research psychology consumer behavior marketing religion literatures propose testable future research directions conceptual framework research agenda challenge consumer researchers ask deeper questions religious affiliation level religiosity may driving previously established differences consumer behavior uncover psychological mechanisms underlying effects framework complements extends previous literature provides new delineated framework considering research effects religion consumer behavior society consumer psychology published elsevier inc rights reserved
particulate matter pollution china transported eastward korea japan suggested influence surface air quality west coast united states however remote sensing studies inconclusive recent trends chinese emissions transport reconciled different passive remote sensing points view found aerosol optical thickness aot indicator particulate pollution increased start observation period main chinese coastal outflow regions since decrease aot respect reductions observed spring summer fall seasons improvement exported pollution found winter season plain language summary particulate matter pollution china transported eastward korea japan suggested influence surface air quality west coast united states however remote sensing studies inconclusive recent trends chinese emissions transport reconciled different passive remote sensing points view found aerosol optcial thickness aot indicator particulate pollution increased main exit regions china coast since decrease aot respect reductions observed spring summer fall seasons improvement exported particulate matter pollution found winter season
extracting data information manual data repository difficult costly time consuming prospects making decision construction process decision making performed collecting data timely cost effectively data warehouse providing model decision making process programming pertinent knowledge data mining automates process finding predictive information large databases improve decision making construction management artificial neural network ann commonly known neural network one method used data mining clustering one basic data analysis method used data mining construction management problem analyze data obtain quick analysis extraction useful clusters research applied modified learning vector quantization lvq neural network classify construction projects flexible clusters dynamic analysis examples based upon past experiences similar data identify problem suggest suitable alternatives proposed modified lvq technique efficient respect number clusters time system fast accuracy system verified domain experts numerous case examples
three rare earth containing docosatungstates nah woh center dot dyiii iii lli synthesized reaction nawo center dot dimethylamine hydrochloride dmahc center dot aqueous solution characterized elemental analyses spectra thermogravimetric analysis powder ray diffraction pxrd single crystal ray diffraction isomorphous molecular unit consists shaped docosatungstate woh polyoxoanion two supporting cations one disordered ire cation woh polyoxoanion viewed combination two hendecatungstate woh subunits staggered fashion sharing two atoms curves reveal one step weight loss degrees degrees moreover demonstrate characteristic luminescence emission behaviors corresponding ions lifetime decay curves well fitted double exponential function addition cie chromaticity coordinates obtained based corresponding emission spectra dominant wavelengths color purities also calculated elsevier rights reserved
objective identify reinvestment strategies senior health education faculty degree programs methods data individual depth interviews inductively analyzed content results identified strategies grouped around themes growth success work realization optimal fit profession investment interpersonal relationships focus stimulating uplifting experiences pursuit professional personal balance problems coping conclusions reinvestment complex process may mediated frequent experience positive emotions research needs employ positive perspective investigate variables different levels analysis
work surveys students materials engineering carried evaluate different aspects use information communication technologies ict studying habits willingness incorporate new tools based data collection different trends detected concerning use resources interest incorporation new instruments would facilitate studying students basic courses first two years career show interest incorporate new technological resources studying however students upper courses last three years favor proposal way students upper courses use technological resources advanced many times related professional activity also possess information regarding existence resources work online based field study propose incorporate new technological resources teaching methodology systematically progressively throughout course studies proposal considers use free access free charge tool google four progressive levels global evaluation proposal immediate since need follow evolution cohort progressive utilization implemented process takes least five years nevertheless proposal would help teachers professors students carry specific tasks inside outside university
today increasing need researchers demonstrate practical value research generate society past decade experts transdisciplinary research developed numerous principles methods tools making research societally relevant researchers unfamiliar transdisciplinary research may miss opportunities adapt principles tools research projects developing step approach joint use transdisciplinarity experts researchers best align research projects requirements transdisciplinarity successfully applied approach numerous workshops summer schools seminars eth zurich beyond ten questions guide discussions transdisciplinarity experts researchers around research issues identify review societal problems addressed identify relevant actors disciplines clarify purpose form inter action feedback obtained clearly indicates step approach useful tool provides systematic procedure thinking ways better link research societal problem solving
introduction according ihcd beta classification chronic migraine headache occurring days month episodic migraine divided low frequency lfem high frequency hfem depending headache days suffered per month methods performed clinical comparison migraine characteristics according monthly headache days suffered patients divided three groups lfem headache days month hfem headache days month headache days month results analysis included patients previously reported differences replicated however three times clinical differences lfem hfem hfem new model takes headache days cut value would minimally higher predictive capacity statistical differences comparing current classification conclusions hfem patients clinical differences compared patients includes poor outcomes regarding headache related disability impact daily life according findings neurologists headache specialists consider emotional functional impact hfem patients could disabling
major depression major health problem partly due incomplete understanding pathogenic mechanisms disease research efforts mainly focused alterations monoaminergic neurotransmission especially relation serotonergic system due key role regulation mood related biological functions given high heritability estimated unipolar depression genes coding key regulators serotonergic neurotransmission considered optimal candidates present review focused role genes coding serotonin receptors pathogenesis since serotonin transporter enzymes involved serotonin metabolism reviewed elsewhere despite large number candidate gene studies focusing genes coding serotonin receptors results inconsistent replicated findings associations htra gene allele genotype htra gene allele genotype depressive symptoms preclinical imaging post mortem studies humans provide strong support involvement htra htra genes nevertheless inconsistency across previous studies clearly suggests innovative approaches designed order overcome limitations candidate gene studies date appealing methodologies seem full exome genome sequencing genome wide pathway analyses endophenotypes epigenetic biomarkers reported tools may assist detection multiple loci models could potentially explain high percentage susceptibility ascribed genetic factors
wellness critical physicians training general physician workforce present physicians general especially intensive care unit physicians experiencing high rates depression burnout prevalence burnout greatest resident fellow trainees accreditation council graduate medical education recognized importance physician wellness proposing common program requirements pertain trainee faculty well several individual focused organizational structural strategies described literature helpful decreasing burnout successful implementation trainee wellness program requires institutional resources collaborative efforts institution leadership faculty trainees ensure greatest effect reducing burnout training programs institutions create programs intervene organizational individual levels additional steps implement trainee wellness program include following establish support institutional divisional leadership create wellness committee perform needs assessment assess trainee wellness burnout perform targeted interventions routinely reassess trainee wellness burnout research needed identify refine strategies improve wellness decrease burnout among physicians trainees community must take challenge improving wellness among physicians benefit trainees patients
according called self licensing effect committing virtuous act preceding choice may lead behave less virtuously succeeding decision consequently well intentioned policies lead overall counter productive effects licensing people behave badly related behaviors side motivational crowding theory argues constraining people adopt desirable behavior backfire use classroom experiment test whether regulatory framework incentivize individuals adopt pro environmental behavior generate similar spillovers terms licensing effect non regulatory framework show way good deed caused seem influence licensing effect nevertheless found business environmental orientated majors react adversely regulatory framework show environmental orientated students exhibit higher intrinsically motivations business orientated ones accordingly suggest licensing effect likely arise preceding virtuous act freely chosen respectively regulatory caused non intrinsically respectively intrinsically motivated individuals
previous bioinformatics analysis identified mycobacterium tuberculosis proteins orthologs eukaryotic proteasome assembly chaperone pac set investigate whether function proteasome assembly solved crystal structure resolution angstrom showed overall fold similar pac family proteins include archaeal pbab yeast pba however formed trimers whereas pbab forms tetramers pba dimerizes pba also found purified could bind tuberculosis core particles finally proteomic analysis showed levels known proteasome components substrate proteins affected disruption tuberculosis work suggests participate bacterial proteasome assembly function importance although many bacteria encode proteasomes tuberculosis uses proteasomes also evolved posttranslational modification system called pupylation deliver proteins proteasome proteasomes essential tuberculosis cause lethal infections animals thus determining proteasomes assembled may help identify new ways combat tuberculosis solved structure predicted proteasome assembly factor isolated genetic mutant tuberculosis structural biochemical genetic studies indicate function proteasome assembly chaperones unlikely roles proteasome biology mycobacteria
work presents new control method track maximum power point grid connected photovoltaic system backstepping controller designed applied buck boost converter order achieve optimal array output voltage nonlinear control based lyapunov functions assuring local stability system control reference voltages initially estimated regression plane avoiding local maximum adjusted modified perturb observe method thus maximum power extraction generating system guaranteed finally converter controlled supply current point common coupling pcc electrical network performance developed system analyzed means simulation platform matlab simulink helped sympowersystem blockset results testify validity designed control method
feo hybrid nanoparticles hnps shown increasing potential biomedical applications image guided stimuli responsive drug delivery incorporation unique properties hnps thermally responsive scaffolds holds great potential future biomedical applications successfully fabricated smart scaffolds based thermo responsive poly isopropylacrylamide pnipam nanoparticles providing localized trigger heating irradiated short laser burst found give rise remote control bulk polymer shrinkage gold coated iron oxide nanoparticles synthesized using wet chemical precipitation methods followed electrochemical coating subsequent functionalization particles allyl methyl sulfide mercaptodecane cysteamine poly ethylene glycol thiol enhance stability detailed biological safety determined using live dead staining cell membrane integrity studies lactate dehydrogenase ldh quantification peg coated hnps show significant cytotoxic effect adverse cellular response exposure cells carried forward scaffold incorporation pnipam hnp composite scaffolds investigated potential thermally triggered systems using switched yag laser studies show incorporation hnps resulted scaffold deformation short irradiation times seconds due internal structural heating data highlights potential hybrid scaffold constructs exploitation drug delivery using methylene blue model drug released remote structural change scaffold
gamma receptors family cell surface receptors expressed host different innate adaptive immune cells mediate inflammatory responses binding portion immunoglobulin humans five low affinity receptors encoded genes fcgra fcgrb fcgrc fcgra fcgrb located segmental tandem duplication chromosome shows extensive copy number variation cnv deletions fcgrb suggested increase risk inflammatory diseases systemic lupus erythematosus rheumatoid arthritis study identify deletion breakpoints fcgrb deletion alleles population endogamous native american population show alleles likely identical descent also localize duplication breakpoint confirming mechanism cnv generation nonallelic homologous recombination identify several alleles gene conversion events using fosmid sequencing data use information structure deletion alleles distinguish fcgrb deletions fcgra deletions whole genome array comparative genomic hybridization acgh data reanalysis published acgh data using approach supports association fcgrb deletion increased risk large cohort cases controls odds ratio published wiley periodicals inc
texture characterisation freeform non euclidean surfaces becoming increasingly important due widespread use surfaces different applications additive manufacturing four main steps required analyse characterise surfaces include new surface representation surface filtration decomposition texture representation methods finally calculation surface parameters recently representation well filtration decomposition freeform surfaces investigated algorithms proposed paper however shed light represent texture freeform non euclidean surfaces calculating parameters novel model freeform surface parameterisation introduced new model proposes use projection algorithm actual calculation parameters different projection algorithms adopted mesh projection techniques found field computer graphics results applying algorithms represent texture simulated bioengineering surfaces shown also comparison algorithms carried furthermore examples calculating surface parameters freeform surfaces given elsevier ltd rights reserved
background dorsolateral nigral hyperintensity ironsensitive magnetic resonance imaging mri sequences seems typical finding parkinson disease studies involved small samples heterogeneous controlpopulations objectives objective study perform meta analysis dorsolateral nigral hyperintensity imaging marker methods methods included systematic literature search hierarchical summary receiver operating characteristics curve approach results identified studies suitable analysis including control cases meta analysis showed overall sensitivity specificity absence dorsolateral nigral hyperintensity versus controls tesla tesla descriptive analysis among studies including patients non parkinsonism showed dorsolateral nigral hyperintensity absent cases atypical parkinsonian disorders cases non neurodegenerative parkinsonism moreover studies absence dorsolateral nigral hyperintensity predicted ipsilateral dopamine transporter deficiency sensitivity specificity conclusions visual assessment dorsolateral nigral hyperintensity iron sensitive mri sequences provides excellent diagnostic accuracy versus controls moreover loss appears marker nigral pathology holds potential differentiation neurodegenerative non neurodegenerative parkinsonian disorders international parkinson movement disorder society
aim anorexia nervosa long considered culture bound syndrome western countries however studies found anorexics cultures instance china prevalence incidence anorexia china seem lower west increase suggests influence cultural factors anorexia could thus culture change syndrome arising fast sociocultural changes individual scale occasion migration societal scale transcultural psychiatrists consider acculturation culture clash conflict different cultural models risk factors developing eating disorders knowledge male anorexia nervosa limited studies pathology transcultural setting method clinical illustration male anorexia china purpose show impact cultural transcultural factors emergence psychopathology symptomatology care male anorexia society experiencing rapid change results zang presented atypical symptoms absence denial weight loss transitory fat phobia atypical food restrictions also presented symptoms found descriptions cases western countries perfectionism obsessional disorders autonomy difficulties development zang anorexia seemed linked culture clash acculturation process discussion absence denial weight loss zang transitory fat phobia could explained traditional non valuation thinness china abdominal pains could accepted idiom distress china patients suffering anorexia nervosa might reflect social disharmony zang culture clash shows desire one hand decide future hand filial duty acculturation could explain development pathological eating behaviours via valuation dieting attitudes adoption ideal thinness concerning therapeutic approach family therapy adapted chinese setting seemed appropriate patient mainly redefine way good son conclusion clinical case questions use western diagnostic criteria meaning symptoms relevant therapeutic approaches patients suffering anorexia outside western countries transcultural approach enables reconceptualization enrichment diagnostic therapeutic approach male anorexia elsevier masson sas rights reserved
individual differences personality traits impulsivity trait anger well environmental variables impact aggressiveness tested model incorporating related variables impulsiveness trait anger aggression incorporated possible mediating influences leisure time activities regression analyses data pre adolescents adolescents females study evaluating spanish version buss perry aggression questionnaire santisteban alvarado recio showed relation impulsiveness barratt impulsiveness scale aggression trait anger spielberger state trait anger expression inventory time spent watching playing video games time spent homework related impulsiveness also related physical well verbal aggression low moderate coefficients multiple mediation analyses confirm media violence exposure homework respectively aggravating attenuating effects self reported aggression results provide key variables longitudinal studies could reveal causal nature results found cross sectional design elsevier ltd rights reserved
purpose investigate effect daily exposure utero static magnetic fields prenatal development germ cell development fertility exposed offspring adulthood materials methods mice exposed daily utero different static magnetic field strengths bore entrance isocenter mri systems entire course prenatal development results utero exposed male mice revealed effect magnetic field strength weight testes epididymis sperm count sperm morphology fertility exposed pregnant female mice showed reduced fertility terms pregnancy rates litter size pointing normal ovarian function however reduced placental weight offspring intrauterine exposed female mice observed correlated decrease embryonic weight animals exposed strongest magnetic field effect seemed parent dependent since observed embryos fathered utero exposed male mice conclusion repetitive utero exposure strong static magnetic fields impair fertility may parental dependent effect fetal programming regard placental development fetal growth magn reson imaging wiley periodicals inc
learning research teachers record lecture videos class upload lecture videos learning system lecture videos handouts generated automatically traditional classroom help students self learning teacher lecture content development learning services paper proposed teaching assistant system based computer vision help content development learning services lecture videos taken using two cameras merged sides students see clear complete teaching content means segmentation used extract board area connected component technique helps refill board area covered lecturer body use adaptive threshold extract handwritings various light conditions time series denoising technique designed reduce noise according extracted handwritings lecture videos automatically structured high level semantics lecture videos segmented video clips key frames integrated handouts education videos
internal validation techniques used check predictive ability developed models common internal validation techniques split sample methods cross validation methods bootstrapping methods split sample methods inefficient small size data sets bootstrapping methods efficient knowledge computer programming languages cross validation methods popular practice therefore study fold cross validation method cross validation techniques applied validate predictive ability binary logistic regression model binary logistic regression model fitted data set uci machine learning repository results cross validation reveal low value optimism high value statistic fitted regression model indicate acceptable discrimination power developed model
fractional order proportional integral derivative pid controller composed number integer order pid controllers accurate control complex system traditional integer order pid controller values parameters fractional order pid controller play decisive role control effect fractional order pid controller added two adjustable parameters traditional pid controller difficult tune parameters back propagation neural network selected optimize parameters fractional order pid controller order obtain high performance optimized fractional order pid controller traditional pid controller used control motor speed governing system vibration spectrum stator current spectrum different rotating speeds compared analyzed detail results show optimized fractional order pid controller better vibration suppression performance traditional pid controller reason optimized fractional order pid controller changed stator current component changed frequency components amplitude vibration signal motor
address large house building demand developing countries soil used alternative building material high availability source material ease processing low environmental impact work soil cement blocks scbs three different contents mineral wool waste soil cement blocks three different contents sisal fiber fabricated microstructurally characterized tested curing moisture absorption abrasion resistance compression bending accelerated erosion increase compression resistance found mineral wool loaded scbs whereas increase sisal fiber lead fold increase rupture modulus results observed bending strength compression resistance increased addition mineral wool waste sisal fiber american society civil engineers
identification fungal pathogens clinical samples hybridization short oligonucleotide probes increasingly used diagnosis invasive fungal infections rapid specific fungal identification documented different diagnostic settings allowing specific patient management identification fungal pathogens formalin fixed paraffin embedded tissue samples appears rewarding materials stored pathology archives offering insight etiology deep fungal infections often achieved non molecular tests contrast pcr based methods amplification target sequences unnecessary limiting potential contamination localization within infected tissue possible helping distinguish colonization infection
birth children characterized different values body weight body length caused genetic factors conditions characteristics prenatal development important investigate whether differences expressed birth particularly values average improved implementing six month period kinesiological activity childhood purpose research conducted using sample children aged decimal years experimental group boys girls control group boys girls divided two subsamples using mean cluster analysis based body weight length children birth formed subsamples defined average values applied variables groups children average average according development birth motor status children assessed using battery standard motor tests intellectual status applying raven colored progressive matrices quantitative effects applied kinesiological treatment analyzed based initial final status young participants examined variables using multivariate analysis variance covariance qualitative differences defined results factor analyses established statistically significant differences variable space boys girls initial measurement relation experimental control group sample treated overall sample children effects experimental treatment shown significant improvement motor intellectual functioning children experimental group children average average development birth
advent cloud computing internet things iot changing way conceiving information communication systems generally talk iot cloud indicate new type distributed system consisting set smart objects single board computers running linux based operating systems interconnected remote cloud infrastructure platform software internet able provide iot service iotaas context container based virtualization lightweight alternative hypervisor based approach adopted smart objects enhancing iot cloud service provisioning particular considering different iot application scenarios container based virtualization allows iot cloud providers deploy customize flexible fashion pieces software smart objects paper explore container based virtualization smart objects perspective iot cloud scenarios analyzing advantages performances
autoimmune myelofibrosis rare distinct clinicopathological entity occur isolation primary association systemic autoimmune disorders secondary systemic lupus erythematosus sjogren syndrome disease characterized isolated combined chronic cytopenias associated autoimmune phenomena bone marrow fibrosis due rarity disease patients frequently misdiagnosed primary myelofibrosis common form bone marrow fibrosis distinguishing disease entities essential given drastic therapeutic prognostic differences disorders report case primary autoimmune myelofibrosis presenting severe isolated anemia refractory multiple lines therapy patient initially misdiagnosed primary myelofibrosis absence characteristic features primary myelofibrosis lack clonal abnormality cytogenetic molecular studies particularly jak calr mpl mutation analyses confirmed absence aberrant neoplastic process furthermore presence monoclonal cell receptor gamma gene rearrangements delineated presence autoimmune disorder supporting diagnosis primary autoimmune myelofibrosis
physiologic stress chronic heart disease associated increased systemic levels chromogranin cga probnp marathon running causes physiological stress imposes significant cardiac burden polyphenol rich mediterranean asian diets demonstrated exert beneficial effects cardiovascular system study investigated whether pretreatment polyphenol beverage could attenuate physiological cardiac stress associated marathon bemagic trial athletes randomized groups double blinded fashion receiving day beverages either study beverage without placebo polyphenol enrichment approximately gallic acid equivalents per day complex mixture polyphenols blood samples taken weeks day immediately running marathon current substudy cga probnp levels analyzed elisa fastest slowest runners cga probnp levels increased significantly immediately marathon returned baseline marathon neither cga probnp differed significantly athletes receiving study beverage versus placebo separating cohort fast slow runners reveal significant difference regarding cga probnp levels groups study provides evidence polyphenol supplementation attenuates marathon running induced physiological stress cardiac burden fast slow runners
present method simulate flow past bioinspired swimmers starting pictures actual fish overall approach requires skeleton graph generation get level set function pictures optimal transportation obtain velocity body surface iii flow simulations realized cartesian method based penalization technique used automate modeling swimming motion data collected biologists illustrate paradigm simulating swimming mackerel fish elsevier inc rights reserved
transportation engineers face many problems using sand dunes available huge quantities desert areas iraq construction materials roads study consists using sand dunes local material road construction two approaches adopted achieve goal first carrying laboratory tests simulation three layers paved road using steel box model subgrade layer represented sand dunes relative density situe value study oriented well improvement sand dunes using reinforcement two types geosynthetic material two models studied one reinforced single layer geotextile subbase subgrade interface using single layer geogrid depth improve subgrade grouting technique used injection subgrade mixture cement bentonite water using geotextile geogrid leads increase number passes respectively using injection technique increase number passes approach using abaqus program applied find displacement distribution build pavement structure model results obtained laboratory finite elements much encouraging using sand dune construction materials roads however using reinforcement subbase subgrade interface also satisfied minimum stability requirements roads foundation structure sand dunes subgrade layer
assignment rrna gene sequences operational taxonomic units otus computational bottleneck process analyzing microbial communities although active area research difficult overcome time memory demands improving quality otu assignments developed new otu assignment algorithm iteratively reassigns sequences new otus optimize matthews correlation coefficient mcc measure quality otu assignments assess new algorithm opticlust compared algorithms using rrna gene sequences two simulated four natural communities using opticlust algorithm mcc values averaged higher otus generated used average neighbor distance based greedy clustering vsearch respectively furthermore average opticlust times faster average neighbor algorithm fast distance based greedy clustering vsearch empirical analysis efficiency algorithms showed time memory required perform algorithm scaled quadratically number unique sequences data set significant improvement quality otu assignments previously existing methods significantly enhance downstream analysis limiting splitting similar sequences separate otus merging dissimilar sequences otu development opticlust algorithm represents significant advance likely numerous applications importance analysis microbial communities diverse environments using rrna gene sequencing expanded knowledge biogeography microorganisms important step analysis assignment sequences taxonomic groups based similarity sequences database based similarity irrespective database study present new algorithm latter approach algorithm opticlust seeks optimize metric assignment quality shuffling sequences taxonomic groups found opticlust produces robust assignments rapid memory efficient manner advance allow robust analysis microbial communities factors shape
study investigate prevalence subclinical enthesitis synovitis pdus patients psoriasis identify risk factors patients plaque psoriasis age matched controls skin disease study patients without arthritis underwent dermatological assessment pdus examination frequency synovitis higher psoriasis compared control enthesitis found two groups among demographic clinical data predictors synovitis included first degree family history psoriasis odds ratio nail involvement prevalence subclinical synovitis enthesitis chinese patients psoriasis low first degree family history psoriasis nail involvement may risk factors subclinical synovitis enthesitis
games adolescents young people used play play grounds streets replaced recent years cyber games played front computer internet game arcades changing culture particularly brought concept digital game addiction condition stems steadily growing passion digital games excessived uncontrolled usage among adolescents young people game addiction psychiatry literature described impulse control disorder characterized symptoms inability control time spent game playing loss interest activities continuing play despite adverse effects feeling psychologically deprived able play although digital game addiction accepted psychiatric authorities psychiatric disorder yet increasing psychiatry referrals due problems accompanying disorder efforts families seek support solutions evidence similarities types addiction revealed researchers well current prevalence rates factors suggest existence important examination issue despite discussions digital game addiction literature subject increasing article offers overview digital game playing behavior light current literature seeking share findings health care professionals
reuse industrial products construction industry saves natural resources energy time reduces environmental problems related surface disposal mine tailings currently among largest industrial products world yet limited studies conducted evaluate reuse potential moreover abandoned base metal tailings increasingly used developing countries manufacture mortars without control engineering basis environmental concern study experimental program using mechanical tests mineralogical investigations leaching tests presented assess use low sulfide base metal tailings varying properties fine aggregates rendering masonry mortars authentic case study illustrating use moroccan construction additionally presented overall observed main properties affecting performances tailings based mortars residual concentrations fine content tailing fraction using appropriate substitution level may serve active set retardant improving mortars setting time leaching metals also successfully stabilized mortars elsevier ltd rights reserved
following mortality salience control prime black hispanic white college students read murder carjacking auto theft trial transcript defendant belonged racial ethnic group one others black hispanic white mock jurors discriminated frequently judging outgroup defendants guilty mortality salience affected judgments outgroup ingroup defendants heightening perceptions guilt murder case decreasing guilty verdict preferences theft case mortality salience may compel derogation outgroup defendants threaten cultural worldview less threatening ingroup defendants effect however seems restricted crimes like murder sustain death related anxiety
pachydermodactyly pdd greek thick skin finger infrequently recognized benign disorder characterized painless fusiform swelling soft tissues around proximal interphalangeal joints hands histopathologic features include increased dermal accumulation collagen fibers young males predominantly affected pdd quite rare approximately cumulative cases reported worldwide report three new cases pdd taiwan including two female patients except patient habit cracking knuckles patient history patent ductus ateriosus post catheterization histories three patients unremarkable ray bilateral hands revealed abnormal finding except soft tissue swelling around proximal interphalangeal joints laboratory examinations showed negative results local systemic treatment given patients treat pdd exception non steroidal anti inflammatory drugs prescribed one patient short period skin care local irritation avoidance explained three patients long term outcome pdd benign copyright taiwan society microbiology published elsevier taiwan llc rights reserved
despite established practice disabilities service systems person centered planning relatively new practice behavioral health system result little known barriers mental health organizations face implementing person centered recovery planning pcrp fill gap results presented qualitative analysis nine focus groups three public mental health organizations texas implementing pcrp least years findings suggest organizations experienced distinct barriers pcrp implementation categorized consolidated framework implementation research domains intervention characteristics outer setting inner setting characteristics individuals implementation process half barriers fell within inner setting domain suggesting implementation efforts flexible adaptable organizational culture context one quarter barriers fell domain characteristics individuals involved intervention suggests implementation efforts assess impact staff consumers implementation success
background hepatitis virus hcv infection causes hepatocellular carcinoma hcc subtypes non hodgkin lymphoma nhl associations cancers established authors systematically assessed associations hcv infection cancers elderly population methods registry based case control study using surveillance epidemiology end results seer medicare data adults aged years cases patients first cancers identified seer registries controls randomly selected cancer free individuals frequency matched cases age sex race calendar year associations hcv documented medicare claims determined using logistic regression results hcv prevalence higher cases controls hcv positively associated cancers liver adjusted odds ratio aor confidence interval intrahepatic bile duct aor extrahepatic bile duct aor pancreas aor anus aor nonmelanoma nonepithelial skin cancer aor myelodysplastic syndrome aor diffuse large cell lymphoma aor specific skin cancers associated hcv merkel cell carcinoma aor appendageal skin cancers aor inverse associations observed uterine cancer aor prostate cancer aor associations maintained sensitivity analyses conducted among individuals without documented alcohol abuse cirrhosis hepatitis human immunodeficiency virus infections adjustment socioeconomic status associations hcv cancers observed conclusions hcv associated increased risk cancers hcc elderly population notably bile duct cancers diffuse large cell lymphoma results support possible etiologic role hcv expanded group cancers american cancer society
self evaluative emotions depend internalized social standards motivate social action however lack empirical research documenting impact self evaluative emotion year olds prosociality extant research relates children experiences guilt empathetic concern making amends however relationship guilt concern making amends potentially reductive empathetic concern involves similar bodily expressions guilt amend making used distinguish guilt shame children first study relate development positive negative self evaluative emotions empathetic concern prosocial choice making amends spontaneous help results confirm broad capacity self evaluative emotion established preschool years relates empathetic concern moreover social emotions used predict prosocial choice making amends best predicted empathetic concern children responses achievement pride following success lack shame following failure alongside moral pride pride response achievement resilience shame also best predictor spontaneous help data support idea young children prosocial choices may partially driven affective drive maintain ideal self psychologists emphasized order adaptive self evaluative emotion guilt oriented rather shame oriented however adaptive role pride neglected call future research redress focus negative self evaluation moral development explore prosocial potential pride elsevier inc rights reserved
study pseudo comprehensive carbon footprint model fossil fuel power plants presented parameters effects considered study include plant type fuel type fuel transmission type internal consumption plant degradation site ambient condition transmission distribution losses investigating internal consumption degradation site ambient condition effect carbon footprint assessment fossil fuel power plant specific feature proposed model evaluate model sensitivity analysis performed different scenarios covering possible choices investigated parameters results show carbon footprint fossil fuel electrical energy produced transmitted distributed varies kwh equivalent kwh carbon footprint combined cycle natural gas main fuel minimum carbon footprint factors also cause indicative variation fuel type causes variation ambient condition may change result transmission makes carbon footprint larger internal consumption degradation influence result respectively therefore minimize carbon footprint fossil fuel electricity recommended construct natural gas ignited combined cycles low lands temperature low relative humidity high internal consumption least possible maintenance overhaul regular possible
introduction four members pax family pax pax pax pax known expressed pancreas accumulated evidences indicate several pancreatic expressed pax genes play significant role pancreatic development functionality alterations genes involved pathogenesis pancreatic diseases areas covered review summarize ongoing research related pancreatic pax genes diabetes mellitus pancreatic neuroendocrine tumors dissect current knowledge different levels mechanistic studies cell lines performed understand molecular processes controlled pancreatic pax genes vivo studies using rodent models express lack specific pax genes finally describe human studies associating variants pancreatic expressed pax genes pancreatic diseases expert opinion based current literature propose future interventions treat pancreatic neuroendocrine tumors diabetes mellitus could developed via modulation pax pax regulated pathways
trauma memories feel disorganised mundane memories may problematic legal contexts examined whether disorganised feeling makes people susceptible suggestive questioning direct examination whether cross examination safeguard purported examined whether cross examination uncover correct distorted trauma memories showed participants film depicting graphic car accident participants film unfolded temporally disorganised way interviewed participants immediately film regarding seen direct examination included free recall cued recall yes questions misleading hours later second interviewer cross examined participants contrary predictions neither manipulation film temporal organisation participants self reported feelings event disorganisation significantly affected accuracy film direct cross examination recognition memory film instead found regardless whether participants memories distorted direct examination suggestive nature cross examination introduced sufficient doubt participants willing change answers conclude traumatic memories vulnerable suggestive questioning unfortunately cross examination legal system fail safe corrective influence
background machine machine communications represent one main pillars new paradigm internet things iot making possible new opportunities ehealth business nevertheless large number protocols currently available hinders election suitable solution satisfies requirements demand ehealth applications objectives first place develop tool provides benchmarking analysis order objectively select among relevant protocols ehealth solutions second place validate tool particular use case respiratory rehabilitation methods software tool called distributed computing framework dfc designed developed execute benchmarking tests facilitate deployment environments large number machines independence protocol performance metrics selected results dds mqtt coap jms amqp xmpp protocols evaluated considering different specific performance metrics including cpu usage memory usage bandwidth consumption latency jitter results obtained allowed validate case use respiratory rehabilitation chronic obstructive pulmonary disease copd patients two scenarios different types requirement home based ambulatory conclusions results benchmark comparison guide ehealth developers choice technologies regard framework presented simple powerful tool deployment benchmark tests specific environments conditions elsevier ireland ltd rights reserved
present frame invariant method detecting coherent structures lagrangian flow trajectories sparse number case many fluid mechanics applications practical interest method based principles used graph colouring spectral graph drawing algorithms examines measure kinematic dissimilarity pairs fluid trajectories measured either experimentally using particle tracking velocimetry numerically advecting fluid particles eulerian velocity field coherence assigned groups particles whose kinematics remain similar throughout time interval trajectory data available regardless physical proximity one another use several analytical experimental validation cases algorithm shown robustly detect coherent structures using significantly less flow data required existing spectral graph theory methods
backgroundguidelines position papers indicate allergen immunotherapy ait disease modifying treatment including prevention onset new allergen sensitizations however preventive effect shown observational studies aim systematically review efficacy ait preventing onset new allergen sensitizations methodscomputerized bibliographic searches medline embase cochrane library june supplemented manual searches reference lists observational studies randomized controlled trials long term observation period included paired reviewers extracted data study characteristics assessed biases end point risk difference onset new allergen sensitizations patients treated ait pharmacotherapy strength evidence graded based risk bias consistency magnitude effect according grade working group guide resultseighteen studies children adults met inclusion criteria risk bias high one study low evidence supports position ait prevents onset new allergen sensitizations studies reporting reduction onset new sensitizations patients treated ait placebo small studies studies shorter follow showed highest benefit ait conclusionsthe overall evidence provides low grade level evidence supporting efficacy ait preventing onset new allergen sensitizations high quality studies could change estimate
paper generalized variable coefficient calogero bogoyavlenskii schiff equation investigated based bell polynomials auxiliary variable bilinear forms equation obtained one two three soliton solutions given hirota method symbolic computation soliton solutions also constructed multi soliton interaction propagation investigated illustrated properties multi soliton interaction different planes space depend forms variable coefficient positions solitons change wave numbers reverse signs
objectives purpose study analyze parenting experiences mothers children stutter based grounded theory methods participants six mothers children stutter depth interview conducted transcribed analyzed according grounded theory method results data analyzed concepts subcategories categories core phenomenon parenting experiences mothers children stutter sense ultimate repression normality causal conditions core phenomenon found apparent stuttering manifestation phenomenon found reinforced contextual conditions vague expectation child response support others personality tendency personal values putting front found remedial factors respect core phenomenon sense ultimate repression normality among remedial strategies reported ultimate repression normality exploring methods compromise avoidance badgering remedial strategies created confidence low self esteem remorse parenting experiences mothers children stutter classified four types conclusion results study indicated program intended remedy mother sense ultimate repression normality managed clinicians also academy professional association study concluded societal prejudice stuttering needs dealt societal governmental levels
background vast majority people living hiv aids reside low middle income countries particularly sub saharan africa including ethiopia despite huge number service users local area cognitive disorder among hiv patients extensively studied dearth knowledge subject objective study assess prevalence associated factors hiv associated neurocognitive disorder among people living hiv aids antiretroviral therapy art clinics methods institution based cross sectional study conducted april may dessie referral hospital kombolcha health center international hiv dementia scale used screen hiv associated neurocognitive deficits logistic regression analysis used assess predictors neurocognitive disorders result risk hiv associated neurocognitive disorder count cells less aor formal education aor poor medication adherence aor older age aor found significantly associated hiv associated neurocognitive disorders conclusion risk hiv associated neurocognitive disorder found high among people living hiv aids emphasizes need regular cognitive screening early identification appropriate intervention elsevier ltd rights reserved
introduction brain structural changes preclinical alzheimer disease poorly understood methods compared changes cortical thickness adni cohort year follow nia preclinical stages defined cerebrospinal fluid csf biomarker levels also analyzed correlation baseline csf biomarkers cortical atrophy rates results follow stage subjects showed reduced atrophy rates medial frontal areas precuneus compared stage subjects whereas stage subjects presented accelerated atrophy medial temporal structures low csf beta levels associated reduced atrophy rates subjects normal tau levels high csf tau levels accelerated atrophy subjects low beta levels discussion longitudinal data confirm biphasic trajectory changes brain structure preclinical implications trials patient selection use mri surrogate marker efficacy alzheimer association published elsevier inc rights reserved
real time information vital enhance dynamic control management via information sharing analysis order reduce construction conflicts project delays however construction project management programs ineffective project prompt responses especially respect change management work presents novel construction project management system called web project based change management wpcm system wpcm system responds changes information efficiently order facilitate change management among project participants general contractor suppliers subcontractors construction project environment capable increasing information sharing construction change management web based technology also provide cost savings via internet case study involving commercial building project taiwan demonstrates effectiveness proposed wpcm system information sharing change control construction phase addition increasing efficiency change control management general contractor well dynamic project tracking management proposed system enables subcontractors suppliers access manage change information timely future work implement system functions comprehensively apply system additional projects strictly verification reliability
security privacy data one prime concerns today internet things iot conventional security techniques like signature based detection malware regular updates signature database feasible solutions secure systems effectively limited resources programming languages permitting immediate memory accesses pointers often result applications memory related errors may lead unpredictable failures security vulnerabilities furthermore energy efficient iot devices running batteries afford implementation cryptography algorithms techniques significant impact system power consumption therefore order operate iot secure manner system must able detect prevent kind intrusions network sensor nodes base station destabilised attackers article presented intrusion detection prevention mechanism implementing intelligent security architecture using random neural networks rnns application source code also instrumented compile time order detect bound memory accesses based creating tags coupled memory allocation placing additional tag checking instructions access made memory validate feasibility proposed security solution implemented existing iot system functionality practically demonstrated successfully detecting presence suspicious sensor node within system operating range anomalous activity base station accuracy overall proposed security solution presented minimal performance overhead
let connected molecular graph resistance distance two vertices defined effective resistance two corresponding nodes electrical network constructed replacing edge unit resistor kirchhoff index defined sum resistance distances pairs vertices gao gave formulae kirchhoff index two types xyz transformations namely subdivision graph total graph regular graphs paper compute kirchhoff index xyz transformations regular molecular graphs explicit formulae kirchhoff index transformation graphs given terms parameters original graph
paper focused analyzing details one widely used technical discussion forums internet stackoverflow stackoverflow huge source information academics industry practitioners analysis provide useful insights evident growing body work dedicated study platform several papers taken platform analyzing point gain useful insights practices adopted software developers however different current literature objective paper explore habit users specifically want find technical users behave online attempt present new picture focuses human aspect online community neither focus technical aspects platform focus technical capabilities developers rather focus paper explore humanistic point view technical users mine stackoverflow repositories find patterns raise several questions observations presented paper highlight real world implications open call based software engineering platforms conduct survey stackoverflow users find answer one highly talked topics meta discussion forum stackoverflow subject survey concerns changing participation habit users paper progresses forward discuss factors raise issue professionalism ethics online venue findings show several malpractices happening stackoverflow present detailed analysis discuss issues paper
aimsleep duration pattern important implications children health study aims investigate nocturnal sleep duration sleep pattern relationships outdoor play screen time among children aged five years methodsthe study used data healthy beginnings trial undertaken sydney australia data children sleep outdoor playtime screen time reported mothers via face face interviews children five years old cross sectional longitudinal analyses conducted resultsat age five years mother child dyads participated significantly overall increase children nocturnal sleep duration sleep latency earlier bedtime decrease proportion children woke night time additional hour screen time associated three minute shorter sleep minute longer sleep latency four minute later bedtime less likely sleeping hours per night adjusted odds ratio controlling mothers demographics conclusionamong young children screen time outdoor playtime associated sleep duration pattern reducing screen time increasing outdoor playtime might help improving children sleep
magnetorheological fluids new type smart material whose performance evaluated considering three important factors stability viscosity shear yield stress fluids study produce fine antisettling well dispersed fluids appropriate components preparation techniques adopted surface treatment method developed involving different surfactants property tests fluids conducted results demonstrated proposed preparation method decelerated sedimentation fluids viscosity fluids varied temperature shear rate liquid paraffin reduce viscosity fluids gradually oleic acid addition variations shear yield stress magnetic induction intensity volume fraction determined accurately describe shear yield stress fluids limited chain model considers spatial distribution carbonyl iron particles model size magnetic saturation phenomenon proposed comparison theoretical experimental values obtained study indicates seventh order limited chain model effectively calculate shear stress fluids american society civil engineers
study new algorithm discrimination internal faults inrush current conditions power transformers presented first proposed algorithm removes pre fault conditions fault currents currents processed using discrete wavelet transform obtain wavelet matrix correlation matrix computed wavelet matrix know eigenvalues associated frequency scale reduce analysed information algorithm authors going call wavelet correlation modes used identify inrush internal fault currents power transformer validate proposed algorithm simulations carried power systems computer aided design software obtained signals analysed order evaluate performance sensitivity
novel microbial fuel cell mfc developed enhance simultaneous nitrification denitrification snd employing electrons anode cathode chamber reactor consisted membrane aerated biofilm reactor mabr made electroconductivity aerated membrane maximum power density obtained current density external resistance omega compared open circuit system removal rates improved respectively could ascribed electrochemical denitrification anode chemical oxygen demand cod cathode chambers reached maximum coulombic efficiencies ces respectively suggested electroconductivity mabr advantages controlling aeration intensity thus improving snd ces overall eam mfc could successfully generate electricity wastewater whilst showing high capacity removing nitrogen low cod ratio cod elsevier rights reserved
background order provide skills enable people realize potential education develop knowledge aptitudes also contribute formation attitudes positive values education systems judged terms multidimensional character education available information indicates countries differ degree students able acquire cognitive non cognitive competences therefore interest improve comprehension development types outcomes complex process depends personal family school contextual factors empirical studies try explain educational quality considered cognitive results study focuses non cognitive ones methods estimate multivariate multilevel regression model simultaneously analyzes determinants two outcomes attained argentine students program international student assessment pisa study cognitive result achievement level mathematics non cognitive one openness problem solving results types outcomes seem differ explanatory factors schools appear play greater role determination cognitive achievements non cognitive competencies however attributes gender home socioeconomic status significant influence cases furthermore although school characteristics seem less relevant individual ones determination types results also room improve development school conclusions heterogeneity regarding variables explain types school outcomes suggests policies designed improve one different nonetheless development competencies mainly requires improvement socioeconomic educational conditions home
subclinical cushing syndrome condition hypercortisolism absence signs specific overt cortisol excess associated increased risk diabetes hypertension fragility fractures cardiovascular events mortality subclinical cushing syndrome rare estimated adult population despite huge number studies published recent years several issues remain controversial subclinical cushing syndrome screening diagnosis treatment altogether beat cushing syndrome group founded bringing together leading italian experts hypercortisolism related diseases document represents altogether beat cushing syndrome viewpoint regarding following controversial issues subclinical cushing syndrome scs screened subclinical cushing syndrome screen populations risk diagnose subclinical cushing syndrome patients adrenal incidentaloma consequence subclinical cushing syndrome searched address therapy choice patients subclinical cushing syndrome follow adrenal incidentaloma patients subclinical cushing syndrome surgically conservatively treated notwithstanding fact studies faced points may several biases retrospective design small sample size different criteria subclinical cushing syndrome diagnosis believe literature evidence sufficient affirm subclinical cushing syndrome condition harmless currently available diagnostic tools reliable identifying majority individuals subclinical cushing syndrome
foundation wenzhou shoal project soft deep stability control issue building seawalls deep soft foundation solved using composite foundation treatment plastic drainage plates geotextile combining situ monitoring situ monitoring data wenzhou shoal project analyzed settlement prediction analysis conducted basing conventional exponential curve fitting method settlement prediction model presented classified construction soft foundation considering non linear deformation soil consolidation load changes model used settlement deformation characteristics last load predict settlement development next load
current research tested model satisfaction relationship status fear single mediators serial linkage relationship status well measured terms life satisfaction emotional psychological well depression results sample polish participants aged demonstrated link relationship status well fully mediated satisfaction relationship status fear single operating separate mediators well satisfaction relationship status fear single mediators serial addition indirect effect relationship status well satisfaction relationship status larger indirect effect relationship status well satisfaction relationship status fear single operating serial elsevier ltd rights reserved
although great amount research carried effects media audience studies deal process determines viewers identify specific symbolic model instead choosing descriptive study try highlight similarity identification focusing aggressive model identification sample participants male female aged high socioeconomic level viewed different films sequences asked answer questionnaire watching clip questionnaire included adjective list traits best defined favorite characters characters like results show clear correspondence participants self perceived traits perceived main characters film self perceived traits opposed perceived main characters opponents
background objectives majority patients irritable bowel syndrome ibs diagnosed treated primary care aim study investigate implementation rome criteria daily primary care clinical practice adherence general practitioners gps recommended diagnostic approaches ibs patients methods survey consisting questions distributed across european countries used assess gps diagnostic approach ibs use rome criteria daily practice gps perspective aetiology disorder results overall gps completed survey daily clinical practice gps reported usually make positive diagnosis basis symptoms whereas gps reported regular use rome criteria diagnose ibs furthermore responders reported applied additional diagnostics blood tests found necessary perform endoscopy make positive diagnosis ibs referred patients ibs specialist psychological factors frequently selected potential aetiological factor ibs gps overall gps reported systematically including questions psychological symptoms assessment history ibs conclusion one third gps regularly used rome criteria diagnose ibs daily primary care practice ibs largely remains diagnosis exclusion implications terms gps specialty training questions applicability ibs guidelines daily care advocate early positive symptom based diagnosis copyright wolters kluwer health inc rights reserved
background avian pathogenic coli apec lead loss millions dollars poultry annually mortality produce contamination studies verified many immune related genes undergo changes alternative splicing along nonsense mediated decay nmd regulate immune system different conditions therefore splicing profiles primary lymphoid tissues systemic apec infection need comprehensively examined results gene expression rnaseq data obtained three different immune tissues bone marrow thymus bursa three phenotype birds non challenged resistant susceptible birds two time points alternative splice sites exon skipping inclusion identified major alternative splicing events avian primary immune organs systemic apec infection study detected hundreds differentiallyexpressed transcript containing genes dets different phenotype birds days post infection dpi dets psap stta nmd important functions systemic apec infection dets cdc cdk rag polrb psap dnasel transcription start sites tss indicate cell death cell cycle cellular function maintenance predominant host systemic apec conclusions use rnaseq technology bioinformatics tools study provides portrait event nmd primary lymphoid tissues play critical roles host homeostasis systemic apec infection according study plays pivotal regulatory role immune response chicken systemic apec infection via either nmd alternative tsss study elucidates regulatory role immune complex systemic apec infection
background healthcare workers may affect utilization sexual reproductive healthcare srh services quality care thereof example behaviours attitudes hold become hindrance accessing utilizing srh services particularly young people thus better understanding behaviours associated factors needed improve access utilization srh services methods systematic review literature conducted identify studies focusing healthcare workers behaviors personal determinants associated providing adequate srh services sub saharan africa january october five databases searched october using search strategy adapted based technical requirements specific database articles independently screened eligibility two researchers screened full text articles studies met inclusion criteria results negative behaviours attitudes healthcare workers well personal determinants poor knowledge skills srh services related factors like availability essential drugs equipment associated provision inadequate srh services healthcare workers still negative attitudes towards young people using contraceptives likely limit access utilization srh adolescents especially knowledge implementation specific srh components optimum levels according recommended guidelines conclusions healthcare workers negative behaviours attitudes unlikely encourage women general access utilize srh services specifically young women knowledge srh services including basic emergency obstetric care emoc insufficient among healthcare workers ssa
objectives study investigated relationship cognitive emotion regulation emotional problems attachment style among students causal model materials methods sample group included bachelor students tabriz university selected randomly multi stage cluster sampling study instruments revised adult attachment scale raas cognitive emotion regulation questionnaire depression anxiety stress scale dass results findings indicated attachment dimensions predict negative positive emotion regulation strategies cognitive emotion regulation mediated attachment dimensions emotional problems furthermore attachment dimensions direct indirect effect emotional problems conclusions findings current study consistent previous findings theoretical stance indicating predictability mental health indices quality attachment student
ailanthus altissima pollen aap considered emerging cause respiratory allergy united states italy iran however allergenic composition aap still unknown yet characterized present study aimed identify aap allergens using proteomics based approach purpose optimized aap protein extracts analyzed using gel electrophoresis confronted twenty sera individuals respiratory allergy aap season candidate allergens detected using serum allergic patient clinical history aap pollinosis ige binding spots identified using maldi tof mass spectrometry database searching according results aap extracts rich proteins molecular weight distribution ranging kda two electrophoresis aap extracts revealed protein spots ige reactive ige binding proteins identified enolase calreticulin probable pectate lyase conserved hypothetical protein ras related protein rhn like knowledge study first report identifying aap allergens findings open avenues diagnosis immunotherapy aap allergy well cloning molecular characterization relevant allergens biological significance ailanthus altissima colonizes new areas every year iran spreading aggressively worldwide according usda tree heaven present invasive plant states www invasivespeciesinfo gov plants treeheaven shtml come dominate large areas many regions several cases allergy altissima pollen reported united states italy iran however still information sensitizing allergens molecular origin clinical symptoms constitutes serious threat patients suffering respiratory allergies regions knowledge current study describes therefore first panel proteins responsible ige mediated altissima pollinosis using gel based proteomic approach work represents pioneer proteomic investigation simaroubaceae spp provides useful insights studies allergens widely distributed plant family elsevier rights reserved
management melanoma pregnancy challenging maternal benefits fetal risks need balanced present overview incidence demographic clinical characteristics treatment modalities used analysis obstetric fetal maternal outcome recommendations clinical practice provided international network cancer infertility pregnancy database pregnant patients melanoma identified analysed sixty pregnancies eligible analysis fifty percent patients presented advanced melanoma pregnancy stage iii stage diagnosed recurrent melanoma surgery main therapeutic strategy pregnancy four patients advanced melanoma treated pregnancy systemic therapy radiotherapy premature delivery observed ongoing pregnancies induced involved patients advanced melanoma thirty nine percent patients died within years diagnosed stage iii disease pregnancy melanoma present advanced stage pregnancy new systemic therapies may beneficial patients metastatic melanoma may pregnancy compatible patients preterm induction labour need discussed despite short term long term negative effects child copyright wolters kluwer health inc rights reserved
advent multilevel inverter topologies paves path realization renewable energy based microgrids various classes consumers topologies offering concerns design complexity power quality stresses capacitor voltage balancing etc view challenges paper proposes simple modular cascaded multilevel inverter modified uni polar shifted carrier pulse width modulation mcmi mupsc pwm topology microgrids proposed mcmi topology eliminates use clamping diodes capacitors requires input voltage used conventional topology produce amount output voltage leads reduction switching devices rating stresses proposed mupsc pwm reduces magnitude hazardous lower order harmonics shifting higher order components around region integral multiples switching frequency thus proposed mcmi mupsc pwm topology simplifies design multilevel inverters along aforesaid advantages analysis microgrid modelling simulations carried matlab simulink effectiveness proposed topology evaluated calculating various power quality indices dynamic nonlinear loading conditions indices compared conventional topology respect standard tolerances results observed proposed topology improved power quality along elimination inherent problems multilevel inverters enhances plausibility microgrid installations towards smart net zero energy buildings elsevier rights reserved
interface shear strength critical property used engineers evaluate appropriateness products specific applications internal shear strength another critical property composite products geosynthetic clay liners gcls product shear internally interface shear strength mobilized multi component gcls newer type gcl consisting either polymeric membrane liner laminated membrane coating applied one geotextile carriers direct shear testing performed multi component gcls assess internal shear strengths coatings laminates geotextile surface gcl direct shear testing performed multiple coated laminated gcls fine grained sand used interface gcl simulate typical field conditions products testing performed accordance typical parameters astm using two different loading conditions direct shear testing protocol test results observations tests performed discussed
broadband graphene absorber simple structure proposed paper substrate used paper thickness constructed depth grooves periodically treated substrates thickness arranging periodically combination quartz substrate different heights realize superposition two adjacent frequency bands leads broad band characteristic absorber absorption rate absorber obtained software high frequency structure simulator hfss relative bandwidth absorption rate ghz ghz graphene absorber proposed potential development stealth technology
study aimed provide reliable instrument evaluating physicians communication behaviors find communication behaviors could elicit patient trust questionnaires distributed patients asked evaluate physician communication behaviors visited level trust physician factor analysis three factor physician communication behavior scale good internal consistency provided three factors respect caring competence thoroughness patience honesty correlation analysis behaviors identified scale significantly associated patient trust physicians behaviors related competence thoroughness regarded important patient trust privacy eye contact necessary tests procedures considered important moreover within different gender groups age groups patients opinions behaviors strongest least association patient trust little bit different
syndesmophyte occurrence axial bone loss investigated heterozygous tumor necrosis factor tnf transgenic mouse model hutnf arthritis female male hutnf mice compared wild type mice weeks syndesmophytes intervertebral disc space osteoclasts osteoid surface vertebra microarchitecture assessed histomorphometry microcomputed tomography spontaneous syndesmophyte formation detected hutnf compared mice however increased porosity observed mainly peridiscal lumbar vertebra accordingly bone microarchitecture parameters altered hutnf mice decrease bone volume fraction trabecular number thickness weeks compared osteoclast count surface increased moreover non mineralized osteoid surface also increased hutnf weeks despite increased osteoclast osteoid surfaces imbalance observed favour osteoid surface early phase osteoclast surface results demonstrated axial bone loss hutnf model additional common limb arthritis related overexpression tnf however absence syndesmophyte increase osteoid surface suggested chronic inflammation might block bone mineralisation finally relative increased osteoid surface enough compensate high osteoclast activity
background smoking shown reduce health related quality life hrqol patients coronary artery disease cad undergoing percutanous coronary intervention pci either means balloon angioplasty use bare metal stents bms drug eluting stents des widely used related substantial reduction restenosis significantly improved hrqol compared bms study aimed evaluate effects smoking hrqol patients pci des era methods cohort patients admitted cad treated drug eluting stents included prospective observational study patients classified non smokers quitters persistent smokers according smoking status time first admitted hospital first year follow patient prospectively interviewed baseline months year following pci hrqol assessed use medical outcomes study item short form health survey results overall population hrqol scores year follow significantly higher baseline domains year follow hrqol scores persistent smokers still lower non smokers domains except bodily pain mental health quitters domains except bodily pain role emotional mental health significant differences regard scores non smokers quitters except role emotional non smokers higher scores adjustment persistent smokers demonstrated significantly less improvements hrqol non smokers domains except bodily pain social functioning significantly less improvement quitters general health improvements quitters comparable non smokers domains multivariate linear regression analyses showed persistent smoking independent risk factor pcs mcs improvements conclusions persistent smoking substantially diminishes potential quality life benefits des efforts made promote smoking cessation des implantation could greatly improve health quality outcomes
objective parents children autism spectrum disorders asd often focus concerns discussions health care providers however studying child strengths positive parental attributions emerging area focus often highlighted many studies children asd objective study identify parent reported strengths sample children asd methods qualitative study parent report strengths clinical notes children ages presenting team diagnostic evaluation meeting diagnostic statistical manual mental disorders dsm text revision dsm diagnostic criteria asd reported child strengths qualitatively analyzed coded clustered themes results ninety eight charts reviewed five meta themes strengths identified personality characteristics social personality cognitive functioning behavioral characteristics coping mechanisms skills average parents reported strengths cognitive functioning personality characteristics meta themes conclusion pediatricians unique opportunity discuss parental positive perceptions children asd learn strengths
equilibrium reconstruction consists identifying experimental measurements distribution plasma current density satisfies pressure balance constraint numerous methods exist solve grad shafranov equation describing equilibrium plasma confined axisymmetric magnetic field research reviewed six techniques determination plasma position tokamak effects superconducting coils chamber optical flux loops magnetic probes multipole moments techniques two methods based vertical field coil characteristics analytical solution grad shafranov equation first method image processing technique used output signal ccd camera plasma emission intensity profile plasma position obtained compare plasma position obtained using method flux loop method magnetic probe method multipole moments method analytical solution grad shafranov equation sensor less method based vertical field coil characteristics also experimented tokamak results compared discussed hydrogen energy publications llc published elsevier ltd rights reserved
control plays important role wide range industrial applications waste management high non linearity neutralization processes uncertainty plant dynamics key challenges effectively addressed using pid controllers tuned conventional methods available quite often tuning methods used designing pid controllers cohen coon ziegler nichols tyreus luyben address problems particle swarm optimization pso employed tune pid controller neutralization plant pso algorithm one powerful methods resolving non smooth global optimization problems paper mathematical model process developed taking consideration overall plant dynamics pso based pid controller implemented evaluated comparing performance pid
purpose retrograde intrarenal surgery rirs procedure sees increase use every day supported excellent results terms safety feasibility report first case fatal mycotic septic complication neurological patient renal stone disease case presentation case woman year old left solitary kidney history advanced multiple sclerosis epilepsy bedridden percutaneous endoscopic gastrostomy described hospitalized presence recurrent lower urinary tract infections computed tomography scan control revealed obstructive renal pelvic stone multiple stones bladder refusal percutaneous approach rirs planned done intraoperative complications observed postoperative period developed urinary sepsis progressive deterioration general conditions died days rirs septic shock blood culture positive candida glabrata discussion pubmed search fatal complications rirs shows two cases fully elucidated conclusions use flexible ureteroscopes holmium lasers high succes rate nevertheless possibility major complication kept mind order evaluate risk factors adopt preventive measures safety patients
background objective tobacco smoking major risk factor wide range respiratory circulatory diseases active passive smokers well designed campaigns raising awareness problem increasing number smokers seeks medical assistance quit habit context need develop mhealth apps assist manage large smoke quitting programs efficient economic ways objectives main objective develop efficient free mhealth app facilitates management assistance people want quit smoking secondary objectives research also aims estimating economic effect deploying app public health system methods using java xml develop deploy new free mhealth app android called tcontrol tobacco quitting control deploy app tobacco unit santa maria hospital lleida determine stability following crashes app also use survey test usability app differences aptitude using app sample patients finally use mathematical models estimate economic effect deploying tcontrol catalan public health system results tcontrol keeps track smoke quitting users tracking status interpreting offering advice psychological support messages app also provides bidirectional communication channel patients clinicians via mobile text messages additionally registered patients option interchange experiences chat app found stable high performances startup message sending results suggest age gender statistically significant effect patient aptitude using tcontrol finally estimate tcontrol could reduce costs catalan public health system cphs element years conclusions tcontrol stable well behaved app typically operating near optimal performance used independent age gender wide implementation could decrease costs public health system elsevier rights reserved
work computational fluid dynamics simulations performed predict temperature distribution part autoclave run data experimental study used input simulations also comparison numerical results conjugate heat transfer approach used simulations best agreement experiments obtained simulation included thermal radiation utilized experimentally obtained velocity profile inlet velocity yet detailed inlet velocity profile advanced turbulent model could result even better agreement
background aim liver stiffness value determined using transient elastography used assess degree liver fibrosis study investigated whether predict recurrence hepatocellular carcinoma hcc radiofrequency ablation rfa methods study retrospectively enrolled patients hcc received rfa first line treatment hcc cox regression analysis used identify independent predictors hcc recurrence results median age study population men women years study period hcc recurrence mortality developed patients rfa respectively liver cirrhosis platelet count multiple tumors value independent predictors hcc recurrence study population stratified early months recurrence groups value independent predictor late recurrence along liver cirrhosis spleen diameter risk late recurrence higher patients values kpa values kpa adjusted hazard ratio confidence interval recurrence predictor overall survival conclusions findings study suggest measurement using useful predictor hcc recurrence rfa
traction control system tcs used avoid excessive wheel slip via adjusting active brake pressure engine torque vehicle starts fiercely split friction slope road complicated conditions tcs operated conditions traction control performance vehicle might deteriorated vehicle might lack drive capability lose lateral stability regulated active brake pressure engine torque match promptly effectively order solve problem novel coordinated algorithm tcs brought forward firstly two brake controllers including basic controller based friction difference two drive wheels compensating difference fuzzy logic controller assisting engine torque controller adjust wheel slip presented brake control together two engine torque controllers containing basic pid controller wheel slip control fuzzy logic controller compensating torque needed road slope built engine torque control together due simultaneous accurate coordination two regulated variables controlled vehicle start smoothly vehicle test simulation results various road conditions testified proposed method effective robust
background ribonuclease rnase known ubiquitous enzyme involved several cellular functions especially innate immunity recently shown participate adipogenesis rodents developed method measure serum levels rnase analyzed relationship rnase metabolic syndrome mets methods total subjects recruited health check program house rnase immunoassay developed serum rnase levels subjects measured association mets related factors rnase levels assessed results mean serum level rnase subjects mets lower without subjects central obesity elevated blood pressure impaired fasting glucose also lower serum rnase levels comparison without multivariate linear regression analysis diastolic blood pressure beta high density lipoprotein cholesterol hdl beta related serum rnase every increase serum rnase levels associated reduced risk mets central obesity low hdl moreover age inversely related serum rnase levels various analyses conclusions serum rnase levels inversely associated mets unfavorable metabolic profiles age
backgroundpaper food gastrointestinal symptom journals used help irritable bowel syndrome ibs patients determine potential trigger foods primary aim study evaluate feasibility usability clinical utility journals data collection tool secondary aim explore method analyzing journal data describe patterns diet symptoms methodsparticipants asked log three sets day food symptom journals day period feasibility evaluated journal completion rates symptom logging compliance logging fatigability feasibility usability clinical utility journaling also assessed customized evaluation exit interview journal regression analyses conducted examine relationships key meal nutrients subsequent symptoms key resultsmost participants young mean age caucasian women journal completion rates participants logging fatigability half perceived paper journaling food symptoms feasible usable clinically useful thirteen participants demonstrated strong association least one symptom meal nutrient patterns associations differed among participants conclusions inferencespaper journaling food symptoms days day period appeared feasible usable data collection tool ibs patients half perceived journaling least somewhat clinically useful findings study support anecdote food trigger associated symptom vary individual
islamic state iraq syria isis recently carried atrocities middle east localized terror attacks several western countries killing hundreds wounding thousands many executions attacks broadcast within clever media campaigns containing warnings future attacks examined anxiety future isis threat along association self reported sleep difficulties sample adult israelis demonstrated association different models beyond effects additional potential variables noted affect sleep reported health exposure terror exposure isis media psychological variables general anxiety depression post traumatic stress disorder symptoms cases strong positive relationship isis anxiety sleep symptoms obtained issues concerning relationship anxiety future threat sleep symptoms well notion sleep difficulties marker anxiety discussed elsevier ltd rights reserved
article reports observational study exploring effects naturally occurring hearing impairments musicians behaviour communication rehearsing performing two groups three pianists three flautists one group normal hearing others moderately profoundly deaf formed duos working two pieces music movement bach flute sonata new composition profoundly deaf musicians spent significantly time looking talking performers moderately deaf hearing players response hearing players looked talked profoundly deaf partners profoundly deaf players also spent significantly less time complete runs pieces start finish without stops findings implications teaching practice musicians without hearing impairments suggest social factors important success collaborative musical performance
article discussed cost efficiency green building energy technology perspective cost control investment promotion article also establishes model based whole life period cost analysis first give present value calculation formula whole life cycle according survey give value coefficient appropriate evaluation green building cost benefit specific algorithm value coefficient function coefficient cost coefficient determined common technique used comparison given advice combined actual operation three star green building cases
perturbation iteration method generalized systems first order differential equations approximate solutions lotka volterra systems obtained using method comparisons results numerical solutions given method implemented mathematica major computer algebra system package perturbationiteration automatically carries tedious calculations method faculty engineering alexandria university production hosting elsevier open access article license http creativecommons org licenses
given pivotal role social interactions play adolescents well understanding factors influence communication key present study examined relations adolescents communicative perspective taking executive function skills adhd traits explored role communicative perspective taking plays peer relations data collected community sample years olds waterloo canada two communicative perspective taking tasks required participants infer speakers communicative intentions battery tasks assessed adolescents working memory inhibitory control elevated adhd traits associated weaker working memory inhibitory control communicative perspective taking working memory strongest predictor communicative perspective taking highlighting importance communicative perspective taking social interactions adolescents weaker skills area reported worse peer relations findings underscore importance communicative perspective taking adolescents social relations relevance understanding social difficulties faced adolescents elevated adhd traits foundation professionals services adolescents published elsevier ltd rights reserved
inspiring advantages digital peak voltage dpv control digital average current dac control digital average voltage dav control switching converter proposed investigated taking buck converter example dav control algorithm analyzed detail order explore stability system domain transfer function deduced critical equivalent series resistance esr output capacitor obtained finally dav controlled dpv controlled dac controlled buck converter compared time domain simulation results indicate dav control possesses better steady accuracy well dac control addition dav controlled buck converter stable state whole duty ratio moreover dav control dpv control similar load transient performance dav control behaves lower overshoot voltage load variation
processes flat bones growth sutures formation interdigitation human calvaria controlled complex interaction genetic biochemical environmental factors regulate bone formation resorption prenatal development infancy despite previous experimental evidence accounting role main biochemical factors acting processes underlying mechanisms controlling still unknown therefore propose mathematical model processes flat bone suture formation taking account several biological events first model growth flat bones formation sutures fontanels reaction diffusion system two proteins tgf beta tgf beta former expressed osteoblasts allows adjacent mesenchymal cells differentiation bone fronts flat bone latter expressed mesenchymal cells sutures inhibits differentiation osteoblasts bone fronts suture interdigitation modelled using system reaction diffusion equations develops spatio temporal patterns bone formation resorption means two molecules wnt sclerostin control mesenchymal cells differentiation osteoblasts sites results computer simulations predict flat bone growth ossification centers sutures fontanels formation well bone formation resorption events along sutures giving rise interdigitated patterns stages modelled solved finite elements method simulation results agree morphological characteristics calvarial bones sutures throughout human prenatal development infancy elsevier ltd rights reserved
main aim paper identify main causes delays portuguese construction industry impact purpose increasing knowledge causes impacts delays construction projects relative importance index adopted classify importance causes six impacts identified causes delays results show main causes delay slow decision making changes orders unrealistic timescales poor contract specifications financial constraints contractor type bidding contract award process main impacts time cost overruns disputes factor analysis revealed eight high level causes result original causes finally pearson correlation coefficients calculated find relationship extracted factors latent causes impacts revealing lack commitment substandard contracts positively correlated impacts poor consultant performance negatively correlated time overrun findings expected improve scientific community knowledge construction management
drug addiction complex neurological dysfunction induced recurring drug intoxication strategies prevent treat drug addiction constitute topic research interest early stage romantic love characterized characteristics addiction gradually disappear love relationship progresses therefore comparison concordance discordance romantic love drug addiction may elucidate potential treatments addiction focused review uses evidences recent studies compare neural alterations romantic love drug addiction moreover also compare behavioral neurochemical alterations romantic love drug addiction behavioral comparisons find many similarities early stage romantic love drug addiction stage romantic love considered behavioral addiction significant differences exist later stage romantic love drug addiction stage romantic love eventually developed prosocial behavior neuroimaging comparisons suggest romantic love drug addiction display functional enhancement reward emotion regulation network except similar neural changes romantic love display special function enhancement social cognition network drug addiction display special dysfunction cognitive control network neurochemical comparisons show many similarities dopamine system significant differences oxytocin system romantic love drug addiction findings indicate functional alterations reward emotion regulation network system may neurophysiological basis romantic love behavioral addiction functional alterations social cognition network system may neurophysiological basis romantic love prosocial behavior seems system critical factor development addiction discuss strategies treat drug addiction suggest future research investigate system interventions aiming improve cognitive control social cognition functions order develop strategies designed effectively treat drug addiction
developing fully depleted silicon insulator soi cmos readout integrated circuit roic operated temperatures application planned readout circuit high impedance far infrared detectors astronomical observations designed trans impedance amplifier tia using cmos operational amplifier opamp soi technique tia optimized readout signals germanium blocked impurity band bib detector highly sensitive wavelengths first time demonstrated soi cmos opamp combined bib detector result promises solve issues faced conventional cryogenic roics
paper deals new product design framework optimal structural design applications proposed approach called hybrid charged system search css nelder mead algorithm hcssnm offers significant improvements performance existing methods field computer aided design optimisation hcssnm based css nelder mead algorithm used optimisation vehicle suspension arm critically important vehicle safety observed results hcssnm used effectively reduce mass vehicle components maintaining fatigue durability
integrators key building blocks many analog signal processing circuits systems gain conventional opamp integrators severely limited gain operational transconductance amplifier ota used implement process scaling reduces transistor output resistance exacerbates issue propose applying ring oscillator integrators rois design high order analog filters rois implemented simple cmos inverters achieve infinite gain low supply voltages independent transistor non idealities imperfections finite output impedance consequently rois scale effectively newer processes prototype fourth order filter designed using rois fabricated cmos occupies area operating supply filter consumes power achieves bandwidth mhz snr sfdr thd measured obtained feeding two tones mhz mhz
introduction drug development repurposing urgently needed individuals autism spectrum disorders asd psychiatric comorbidity often presents aggression self injury areas covered review dopamine antagonists including classical atypical well unconventional antipsychotics asd older antipsychotic loxapine discussed terms preliminary albeit limited evidence asd emerging promise amitriptyline asd discussed together promising bdnf effects loxapine amitriptyline expert opinion asd pharmacotherapy specifically dopamine antagonist drugs often prescribed challenging behaviors including aggression novel antipsychotics risperidone aripiprazole received study asd fda approved irritability children asd age years individuals asd prone weight gain type diabetes associated side effects low dose loxapine properties classical novel antipsychotics importantly appears weight neutral promising use adolescents adults asd amitriptyline appears effective asd irritability aggression gastrointestinal problems insomnia children adolescents adults however adult data amitriptyline asd still preparation publication loxapine amitriptyline may stimulate bdnf studies warranted
millennial generation grew period changing gender roles labor force participation mothers young children rapidly increasing past research found daughters employed mothers likely defy traditional gender scripts seeking employment authority positions building literature assess whether exposure full time employed mother impact millennial women participation political organizations use prospective data childhood context panel study income dynamics apply propensity score weighting matching technique based covariates evidence suggests exposure full time employed mother increases participation political organizations low ses daughters according sensitivity tests findings reasonably robust unobserved confounders contrast exposure full time employed mother significant effect participation sons high ses daughters elsevier inc rights reserved
amplitude reduction one common correlates externalizing however studies used experimental manipulations designed challenge different cognitive functions order clarify processes impact reduction examine factors moderating amplitude trait externalizing administered back task manipulated cognitive control demands working memory load incentives sample male offenders offenders high trait externalizing scores display global reduction amplitude rather negative association trait externalizing amplitude specific trials involving inhibition dominant response infrequent stimuli context low working memory load incentives performance addition discuss potential implications findings externalizing related psychopathologies results complement expand previous work process level dysfunction contributing externalizing related deficits elsevier rights reserved
developed new model simulate supplemental irrigation hydro economic potential rainwater harvesting system rainfed agricultural areas using model soil moisture rainfed crop land supplemental irrigation requirements rainwater storage farm reservoir ofr system surface ground water availability predicted irrigated system ofr used harvest rainwater rainy season stored water applied cropland supplemental irrigation economic analysis performed calculate benefits due ofr irrigation system gains increased crop yield downstream water availability irrigated ofr system compared rainfed system ofr addition calculated impacts dry wet seasons total value gains grain water gains irrigated rainfed conditions performed sensitivity analysis quantify impacts model input parameters total value gains analyses showed ofr system produce crop yields three times greater rainfed agriculture water stress season total water use irrigated system greater rainfed system water use efficiency irrigated system higher rainfed system dry season total value gains due increased crop yield supplemental irrigation downstream water availability irrigated system greater rainfed system wet season total value gain irrigated system greater rainfed system precipitation scenario analysis wet dry seasons indicated benefits rainwater harvesting system considerably greater dry seasons wet seasons
enhanced vasoconstrictor activity cutaneous arteries participates reduction skin blood flow induced cooling stimulation raynaud phenomenon characterized intense cooling induced constriction cutaneous arteries common women period menarche menopause thus investigated effect beta estradiol cooling induced reduction plantar skin blood flow psbf mouse vivo ovariectomized female ddy mice anaesthetized pentobarbital treated tetrodotoxin eliminating sympathetic nerve tone artificially ventilated psbf measured laser doppler flowmetry cooling air temperature around foot degrees decreased psbf temperature dependent manner suppressed specific adrenoceptor antagonist intravenously administered bolus followed constant infusion min cooling stimulation cooling induced reduction psbf facilitated dose dependent manner facilitatory effect induced treatment similar facilitatory effect induced intravenous application agonist protein coupled estrogen receptor gper also termed gpr moreover facilitatory effect abolished gper antagonist results suggest acute administration leads facilitation cooling induced alpha adrenoceptor mediated reduction skin blood flow via activation non genomic estrogen receptor gper
background pediatric patients non hodgkin lymphoma nhl developing countries dcs present greater tumor load even lower stages comorbidities impact therapy delivery causes toxic mortality standard intensive protocols recurrences gentler treatment objectives developed evaluated risk stratification schema guides intensity therapy design methods sixty nine patients prospectively assigned five risk groups following staging treated protocols risk stratified intensity risk stratification utilized jude stage disease bulk sites involved results patients cell nhl enrolled among boys mean age years range years eighty seven percent burkitt lymphoma advanced stage stage iii stage central nervous system positive mean lactate dehydrogenase increased progressively across risk strata among patients relapsed progressed within risk stratum fifteen patients died three treatment related toxicity median follow years overall event free survival efs patients respectively efs related risk assignment frequency documented infectious noninfectious toxicities increased higher risk group assignment causing prolongation admissions potential treatment delays conclusions reduction treatment intensity identified subset patients nhl feasible high intensity therapy required high risk groups risk stratification system may first step toward improving outcomes dcs
effects portrayals ethnic endorsers advertising ambiguous portrayals strengthen ethnic identity ethnic minority groups thus leading positive responses toward lead negative responses portrayals perceived stereotyped humor tool increase positive effects identity building reduce negative effects stereotyping study investigate humor moderates effects ethnic advertising consumers ethnic minority majority groups find humor supports effects traditional portrayals groups moreover effect traditional portrayals combined humor strongest minority group findings provide evidence positive effects humor ethnic advertising thus provide new insights stereotyping ethnic advertising humor literature findings practical implications advertising using ethnic endorsers humor targeted ethnic minority groups
objectives describe effectively provided adequate prenatal care postpartum contraception prevent repeat unintended pregnancies women using opiates medication maintenance therapy mmt pregnancy methods conducted retrospective chart review women using opiates mmt pregnancies receiving prenatal care regional high risk maternity care clinic july june examined prenatal care usage birth outcomes postpartum contraception using chi kruskal wallis binary logistic regression modeling results patients predominately white multiparous used mmt used prescribed illicit opiates fewer half received documented prenatal counseling postpartum contraception sixteen babies premature sixty four infants diagnosed neonatal abstinence syndrome nas women attended postpartum visits overall women received postpartum contraception significant predictors postpartum contraception use preterm birth postpartum appointment attendance conclusions alternative strategies providing postpartum care explored women using opiates mmt pregnancy significantly likely use postpartum contraception attend postpartum appointments
background dysfunctions brain dopamine serotonin neurotransmission believed involved etiology psychiatric disorders electroretinogram erg anomalies reported psychiatric patients goal study evaluate whether erg anomalies could result central dopamine serotonin dysfunctions changes retinal bioavailability neurotransmitters method photopic scotopic ergs recorded tryptophan hydroxylase knockin tph mice approximately decrease brain serotonin dopamine transporter knockout dat mice showing fivefold increase brain extracellular dopamine dopamine serotonin retinal striatal tissue content also measured role dopamine receptors receptors erg responses evaluated mice results increase photopic wave implicit time observed tph mice wildtype msec msec dat mice showed decrease rod sensitivity wildtype log units log units contrast remarkable alterations brain levels changes dopamine serotonin retinal content found dat tph mice respectively mice showed anomalies photopic scotopic maximal amplitude whereas mice showed higher oscillatory potentials relative contribution wave amplitude conclusion alterations central dopamine serotonin neurotransmission affect erg responses erg anomalies reported psychiatric disorders might serve biomarkers central monoaminergic dysfunction thus promoting erg measurements useful tool psychiatric research
flexure box morphing aileron concept utilizes macro fiber composites mfcs compliant box create conformal morphing aileron work evaluates impact number mfcs performance power mass aileron experimentally investigating two different actuator configurations unimorph bimorph implemented naca airfoil chord unimorph bimorph configurations experimentally tested range flow speeds angles attack degrees aerodynamic loads wind tunnel embedded flexible sensor installed aileron evaluate effect aerodynamic loading tip position design choices effect actuation lift drag pitching moment coefficients measured finally impact aileron mass average power consumption due added mfcs considered results showed unimorph exhibiting superior ability influence flow equivalent power consumption lower overall mass bimorph exhibited superior control aerodynamic forces unimorph experienced significant deformation due aerodynamic loading
study assessed extent high fat diet hfd induced beta amyloid accumulation cognitive decline app psen mice reversible control fat intake ten months hfd calories fat led significant deficits trial maze task nest building assay decreased voluntary locomotor activity hfd induced inflammatory response indicated increased expression several inflammatory markers substituting low fat diet led pronounced weight loss correction glucose intolerance decreases inflammatory response improved performance behavioral tasks wild type app psen transgenic mice insoluble beta amyloid levels extent tau phosphorylation also lower following dietary reversal app psen mice compared high fat fed animals indicating inflammatory response may contributed key pathogenic pathways alzheimer disease model data suggest weight loss vital strategy cognitive protection also highlight potential mechanisms intervention sustained weight loss possible elsevier inc rights reserved
increasing number research studies suggested metacognition associated individuals mental health specifically metacognitive beliefs rumination proposed link onset maintenance depression according metacognitive model depression current study aimed serve pilot study exploring parents metacognitive beliefs parenting characteristics associated rumination related metacognitive beliefs adolescents eighty five parent youth dyads invited complete set questionnaires examining metacognitive beliefs rumination followed difficult puzzle task parent adolescent interaction patterns recorded examine parenting style results found parents adolescents positive metacognitive beliefs rumination significantly associated addition parental negativity significantly associated adolescents positive metacognitive beliefs rumination parental involvement marginally associated adolescents negative metacognitive beliefs rumination findings highlighted association parental factors adolescents metacognitive beliefs rumination implications prevention adolescent depression discussed
sixties seventies limited presence women public sphere reflected restricted repertoire roles played female characters television fiction mainly mothers wives strengthening feminist movement following decades increased diversified portrayals women workplace encouraged academic research social construction working women despite relevance female professionals current shows importance romantic relationships sexuality led decreasing number studies subject article summarizes results study working women spanish fiction part larger project construction female identities research uses original methodology combines quantitative techniques qualitative methods socio semiotics analyse sample female characters results show coexistence traditional stereotypes working women customer service care giving positions highly skilled female professionals however empowerment women positions responsibility often associated negative portrayal character problems reconciling family work systematically avoided
critical heat flux chf important thermal hydraulics design safety analysis purpose validate chf data acquired thtf npic experimental investigation repeatability chf data carried full length non uniform axial heat flux distribution rod bundle repeatability chf data thtf examined comparing data run different time data different runs rod bundle powers chf data acquired well controlled parameters directly compared reference measured data htrf columbia university rod bundle power ratio chf data employed describe repeatability chf data thtf htrf variations power ratio inlet outlet parameters show reasonable trend point point differences chf power two facilities every single point found within result demonstrates good repeatability data thtf data htrf thtf capable acquiring reliable repeatable chf data verifying thermal hydraulics performance pwr fuel assemblies elsevier ltd rights reserved
programming beginners becoming increasingly difficult understand since innovative tools immediately throw students environment must build everything program nothing inconsequential programming skills little knowledge programming concepts programming based careers rising demand important help beginner programmers bridge gap understanding program developing one robot chronicle offers solution dilemma different approach common state machines scratch alice playmaker code spells introduces basic concepts programming puzzle based video game
thermoelectric energy harvesting system designed harvest tens microwatts several milliwatts low voltage thermoelectric generators presented paper proposed system based two stage boost scheme self startup ability maximum power point tracking technique based open circuit voltage adopted boost converter high efficiency experimental results indicate proposed system harvest thermoelectric energy run microcontroller unit wireless sensor node low input voltage power high efficiency harvest system wireless sensor node self powered minimum thermoelectric open circuit voltage input power self startup scheme proposed system self start input voltage low power designs applied system reduce quiescent dissipation power results better performance considering conversion efficiency self startup ability compared commercial boost systems used thermal energy harvesting elsevier ltd rights reserved
cardinal trees tries degree fundamental data structure particular many text processing algorithms node cardinal tree children labeled symbol alphabet paper introduce succinct representations dynamic cardinal trees nodes requiring bits space first dynamic cardinal tree representations support fairly complete set operations using almost optimal space show navigational query operations tree supported time supporting insertions deletions leaves amortized time show set operations supported time amortized case insertions deletions also show associate bit satellite data tree nodes using extra bits finally show machinery introduced dynamic cardinal trees adapted represent dynamic binary trees using bits space tree operations supported time amortized case insert delete operations support adding satellite data tree nodes using extra bits extra bits fastest previous dynamic representation literature providing several trade offs accessing modifying data
expertise construction typically associated esoteric experts occupy privileged positions possession specialist skills knowledge conceptual piece attempt made broaden view expertise found construction management literature drawing reading process philosophical writings henri bergson others reading expertise processual standpoint argued conceptualization expertise construction management move beyond treatment thing bring fore expertise open ended ongoing ever evolving process becoming heart ontological shift expertise construction lies emphasis tacit recognition expertise time interactional intuitive incidental ideas illustrated vignette environmental expertise airport context
paper proposes modified evolving participatory learning mepl method identify fuzzy systems nonstationary streaming data proposed algorithm includes new rule adding merging strategies well improved initialization method consequent parameters firstly noticing missing existing approaches useful output signals used rule adding new rule adding strategy utilizing input output data proposed secondly new rule merging strategy proposed rule similarity merging decided combining similarities centers shapes different existing approaches use similarity centers membership functions determine merging fuzzy rules finally special method proposed determine initial values parameters consequent parts new added fuzzy rules numerical results indicate mepl give accurate prediction results often performs better state art algorithms accordance accuracy
individuals antisocial behavior place great physical economic burden society deficits emotional processing recognized fundamental cause antisocial behavior emerging evidence also highlights significant contribution attention allocation deficits behavior comprehensive literature search identified studies eligible inclusion meta analysis compared individuals antisocial problems controls signed differential mapping revealed compared controls gray matter volume gmv subjects antisocial behavior reduced right lentiform nucleus left insula left frontopolar cortex fpc increased right fusiform gyrus right inferior parietal lobule right superior parietal lobule right cingulate gyrus right postcentral gyrus given well known contributions limbic paralimbic areas emotional processing observed reductions gmv regions might represent neural correlates disturbance emotional processing underlying antisocial behavior previous studies suggested fpc role attention allocation emotional processing therefore gmv deviations area may constitute neural basis deficits attention allocation linked antisocial behavior
studied production biodiesel microalga chlorella protothecoides sag direct saponification wet biomass moisture microwave reactor using ethanolic potassium hydroxide resulting soap precipitated common ion effect using saturated solution potassium chloride subjected simultaneous acidulation esterification form biodiesel optimum parameters saponification temperaure degrees ethanol dry biomass ratio concentration koh microwave power esterification temperature degrees sulfuric acid molar ratio methanol fatty acids microwave power kinetics thermodynamics saponification esterification investigated reactions found follow pseudo first order kinetics activation energies determined mol mol saponification esterification respectively final biodiesel yield purity respectively
background design skin care includes use cleaning cosmetic products nourishing moisturizing sunscreen etc specially prepared different skin types study aimed determine knowledge behaviors skin care moisturizers patients attending dermatology outpatient clinics materials methods patients attended dermatology outpatient clinic reason march may requested fill questionnaire containing questions knowledge skin care products moisturizers use using behaviors get knowledge things consider choosing ask advice products buy products things consider buying results study involved patients female male patients defined skin care cleaning patients lack skin disease patients knew one skin care product two skin care products products patients idea patients using skin products using regularly using sometimes patients using skin care product subjects stated get information dermatologists via internet via advertisements neighbors subjects stated get information pharmacy choosing skin care products patients regularly using moisturizers patients using sometimes using moisturizers conclusion patients behavior using skin care products regularly society needs informed regular skin care choosing right moisturizers buying products appropriate places well using products correctly
background malaria disease caused protozoan parasites genus plasmodium transmitted female anopheline mosquitoes major cause morbidity mortality loss productivity humans baringo county prone seasonal transmissions malaria mostly rainy seasons methods cross sectional study used mixed methods approach collect data knowledge lay management malaria questionnaire survey administered respondents qualitative data collected focus group discussions four ecological zones covering baringo north baringo south marigat sub counties baringo county analyses done summary inferential statistics quantitative data content analysis qualitative data results study communities knowledgeable malaria signs symptoms cause seasonality biomedical knowledge existed local perceptions knowledge however influence first second choice treatments compliance medication respondents reported suffered malaria onset suspected malaria case community members reported following visited health facility used analgesics herbal treatments remnant malaria medicines counter malaria medicines traditional healers treatments nearly respondents reported visiting health facility subsequent treatments herbal treatments comprised infusions decoctions derived roots barks leaves plants believed medicinal value compliance conventional malaria treatment regime however identified challenge malaria management quick relief symptoms undesirable qualities like drug bitterness bad smell undesirable side effects nausea long regimen treatment contributors non compliance men women exhibited different health seeking behaviours based cultural expectations masculinity femininity gender roles acceptability health services conclusions knowledge malaria important identifying disease necessarily lead good management practice treatment seeking behaviour also influenced perceived cause severity disease timing anticipated cost seeking treatment gender besides availability traditional conventional medicines
super majorities occurred frequently congress escaped scholarly attention paper employs new measures positive agenda control unique data set nontrivial bills answer two questions legislative leaders construct veto proof coalitions presidents legislative leaders argue deployed procedures expand sustain veto proof coalitions despite increasing polarization resulting history signaled members commitment bill provided information president reduced uncertainty possibilities interbranch bargaining likely success veto find positive agenda control increased probability vote tallies two thirds especially election addition demonstrate presidents concentrated veto activity bills outcomes less two thirds rejected veto proof bills reputational gains deployed signing statements strategically analysis suggests congressional leaders paradoxically gained capacity nurturing large bipartisan alliances institution became polarized moreover demonstrates strategic activity legislative leaders critical explaining variation presidential options veto bargaining signing statements
measurement deflections certain bridges usually hampered corruption gps signal multipath associated passing vehicles resulting unrealistically large apparent displacements field data gorgopotamos train bridge greece systematic experiments revealed bias due superimposition two major effects changes geometry satellites partial masking certain satellites passing vehicles effect faced solutions excluding satellites get temporarily blocked passing vehicles dynamic multipath caused reflection satellite signals passing trains high frequency multipath effect different static multipath dynamic multipath seems rather irregular amplitude depending geometry measured satellites typical pattern mainly consisting baseline offset wide base peaks correlating sequence main reflective surfaces vehicles passing next antenna cases limited corruption gps signal dynamic multipath corresponding scale distortion short period component gps waveforms propose algorithm permits reconstruct waveform bridge deflections using weak fusion gps rts data based complementary characteristics two instruments application proposed algorithm managed extract semi static dynamic displacements oscillation frequencies historical railway bridge train loading using noisy gps rts recordings combination gps rts possible two sensors fully collocated complementary characteristics rts gps focusing long short period characteristics displacement respectively
background last years growing interest self compassion empirical evidences show self compassion associated psychological benefits among young adults might considered buffer factor several mental disorders aims aim study validate psychometric properties self compassion scale scs neff initial lack replicating original six factor structure method data collected overall database research centre men women mean age comprised four groups borderline personality disorder anxiety disorder eating disorder general population results confirmatory factor analysis supported two factor model self compassionate attitude versus self critical attitude good internal consistencies construct related validity external validity configural weak measurement structural invariance two factor model scs also shown conclusions findings support generalizability two factor model show properties interpretations scores self compassion equivalent across population groups copyright john wiley sons ltd
paper presents implementation taguchi method retrofit design line start permanent magnet motor evaluate viability method optimum designs obtained taguchi traditional optimization methods compared outlines respective advantages disadvantages methods shows taguchi method efficient robust design approach possesses unique advantages compared conventional design methods design sensitivity investigation regarding variances certain parameters due manufacturing tolerances material properties discrepancies also presented using taguchi method investigation insight contribution parameter towards machine performance gained steady state performance embedded radial flux line start permanent magnet motor
varenicline widely used effective drug smoking cessation partial agonist alpha beta nicotinic acetylcholine receptor nachr full agonist alpha nachr reported varenicline aggravates formation atherosclerotic plaques alpha nachr apolipoprotein knockout mice however little known effects macrophages atherosclerotic plaques ascertained whether varenicline promotes oxidized low density lipoprotein oxldl uptake mouse peritoneal macrophages vitro clarified mechanism investigated effects varenicline expression scavenger receptors lectin like oxidized ldl receptor lox cluster differentiation scavenger receptor class raw cells expression protein mrna determined western blotting real time quantitative reverse transcriptionpolymerase chain reaction respectively effects varenicline oxldl uptake examined counting number macrophages stained oil red hematoxylin varenicline significantly increased expression protein mrna lox raw cells increased oxldl uptake macrophages effects varenicline blocked significantly alpha nachr antagonist methyllycaconitine mla alpha beta nachr antagonist dihydro beta erythroidine hydrobromide beta data suggest varenicline promotes oxldl uptake upregulating expression lox alpha nachr macrophages found varenicline significantly activated extracellular signal regulated kinase erk nuclear factor kappa kappa signaling pathways raw cells activation blocked mla beta therefore erk kappa signaling pathway highly likely responsible varenicline induced upregulation lox expression nachr macrophages processes probably contribute varenicline aggravated atherosclerotic plaque formation hence increased risk cardiovascular events upon varenicline treatment could occur must considered patients especially suffering cardiovascular diseases elsevier rights reserved
promising results seen studies secondary bile acids experimental colitis suggest may represent attractive safe class drugs treatment inflammatory bowel diseases ibd however exact mechanism bile acid therapy confers protection colitogenesis currently unknown since gut microbiota plays crucial role pathogenesis ibd exogenous bile acid administration may affect community structure microbiota examined impact secondary bile acid ursodeoxycholic acid udca taurine glycine conjugates fecal microbial community structure experimental colitis daily oral administration udca tauroursodeoxycholic acid tudca glycoursodeoxycholic acid gudca equally lowered severity dextran sodium sulfate induced colitis mice evidenced reduced body weight loss colonic shortening expression inflammatory cytokines illumina sequencing demonstrated bile acid therapy colitis restore fecal bacterial richness diversity however bile acid therapy normalized colitis associated increased ratio firmicutes bacteroidetes interestingly administration bile acids prevented loss clostridium cluster xiva increased abundance akkermansia muciniphila bacterial species known particularly decreased ibd patients conclude udca fda approved drug cholestatic liver disorders could attractive treatment option reduce dysbiosis ameliorate inflammation human ibd importance secondary bile acids emerging attractive candidates treatment inflammatory bowel disease although bile acids may affect intestinal microbial community structure significantly contributes course inflammatory disorders impact bile acid therapy fecal microbiota colitis yet considered studied alterations fecal microbial abundance colitic mice following administration secondary bile acids results show secondary bile acids reduce severity colitis ameliorate colitis associated fecal dysbiosis phylum level study indicates secondary bile acids might act safe effective drug inflammatory bowel disease
purpose purpose study describe prevalence rate hospital acquired pressure injuries hapis pediatric patients design descriptive secondary analysis data pressure injuries among pediatric patients national database nursing quality indicators ndnqi subjects setting sample included patients day years old pediatric acute care units general pediatrics pediatric critical care neonatal intensive care pediatric step pediatric rehabilitation units hospitals submitted pressure injury data ndnqi least quarters results pressure injury prevalence prevalence hapi rate hapi among males rate among females hapi rates highest among children ages years years lowest among patients days age unit type hapis highest among patients pediatric critical care units pediatric rehabilitation units lowest general pediatrics units hapis stage stage deep tissue pressure injuries unstageable pressure injuries conclusion acutely ill children develop pressure injuries including hapi study findings provide data hapi large sample hospitalized children pediatric unit type comparison purposes
patients primary sclerosing cholangitis psc frequent episodes cholangitis potential high mortality waiting liver transplantation however data wait list mortality specific liver disease etiology limited using united network organ sharing unos database listed patients died waiting transplant primary biliary cirrhosis pbc patients compared psc differed age years female gender black race bmi total patients died waiting transplant list using competing risk analysis controlling baseline recipient factors accounting receipt liver transplantation pbc compared patients psc higher overall month wait list mortality respectively gray test repeat analysis including etiologies showed higher wait list mortality pbc compared etiologies except patients listed diagnosis alcoholic liver disease ald hepatitis virus hcv patients pbc high mortality waiting liver transplantation novel findings suggest patients pbc listed may considered model end stage disease meld exception points
underwater wireless sensor networks networks composed various underwater sensor nodes usns able communicate vast majority earth surface composed water makes networks interesting research topic enables variety applications oil monitoring real time water pollution control design usns paramount network operation comparison terrestrial wireless sensor nodes usns expensive larger present greater energy consumption due harsh conditions aquatic environment leads different challenges need addressed design node including processing communications energy management data sensing storage survey aids development underwater sensor nodes underwater applications present general architecture usns discuss basic functions must accomplished unit also present comprehensive study elements compose sensor node including microcontrollers memories sensors batteries highlight aspects pivotal importance design usn affect communication protocols applications believe survey facilitate guide development future uwsn applications protocols
important part nanchang hangkong university professionals training aviation feature constructing characteristic major aircraft manufacturing engineering meeting need development aviation manufacturing industry regional economy paper introduces construction provincial characteristic major aircraft manufacturing engineering firstly constructing goal characteristic major proposed professional curriculum practice teaching teacher team subsequently detail measures constructing characteristic major described establishing special opening professional curriculum setting aviation feature practice teaching platform cultivating interactive teaching research teacher team finally brief account quality evaluation personnel training given
wave digital filters class digital filters equivalent commensurate transmission line circuits synthesized uniform lossless commensurated transmission lines order extend applications physical wave phenomena including quantum electronics necessary consider generalized distributed line whose velocity energy flow frequency characteristics paper discusses generalized distributed circuit obtain two types lines lossless cut order analyze lines discuss signal flow graphs steady state voltage current reflection factors obtain active power diagonal element scattering matrix zero conjugate matching using reflection factor obtain band pass filters synthesized cut lines also describe analysis method nonuniform line related riccati differential equation
senior author introduced transpalpebral approach first time asps meeting made refinements technique developed newer indications procedure refinements indications related new video subject report modifications technique follows elevation skin orbicularis muscle dissection muscle thin layer depressor supercilii muscle overlying darker friable corrugator supercilii muscle removed fairly constant branch supraorbital nerve piercing muscle medially first identified surface followed deep muscle using mosquito hemostat muscle lifted nerve branch identified periosteum segment muscle lateral nerve isolated removed first transecting medially lateral nerve cephalic segment isolated removed using coagulation power cautery minimize postoperative bleeding rest muscle removed piecemeal fashion thoroughly possible including lateral segment procerus muscle end point visualization subcutaneous fat intention surgery treat frontal migraine headaches supratrochlear supraorbital arteries also removed nerve vessel pass foramen foraminotomy carried patients migraine headaches two three fat injected glabellar corrugator sites patients avoid depression restore lost glabellar volume beyond patients male pattern baldness long forehead overactive frown muscles optimal eyebrow positions technique used proptosis exophthalmos eyelid ptosis would undergo ptosis correction prevent elevation eyebrows exaggerates proptosis makes eyelid ptosis discernible additionally common indication surgery patients frontal migraine headaches report highlights refinements transpalpebral corrugator resection implemented last years offers additional indications utilization
background irinotecan cpt causes intestinal mucositis diarrhea may related changes enteric nervous system ens inflammatory condition mast cells release variety pro inflammatory mediators interact ens cells explored whether cpt able alter enteric glial neuronal cell role mast cells effect therefore study conducted investigate effect cpt enteric glial neuronal cells well study role mast cells cpt induced intestinal mucositis methods intestinal mucositis induced swiss mice injection cpt day days following euthanasia fifth day investigate role mast cells mice pretreated compound days first day second day third day fourth day induce mast cell degranulation cpt treatment results show cpt increased glial fibrillary acidic protein gfap beta gene beta protein expressions decreased huc protein expression small intestine segments concomitantly cpt enhanced tumor necrosis factor tnf alpha interleukin levels inducible nitric oxide synthase inos gene expression associated increase total number macrophages positive cells ionized calcium binding adapter molecule iba degranulated mast cells small intestine segments caused significant weight loss pretreatment compound inductor mast cells degranulation significantly prevented cpt induced effects conclusions data suggests participation mast cells cpt induced intestinal mucositis macrophages activation enteric reactive gliosis neuron loss
elevated risk suicide among veterinarians stimulated research mental health veterinary profession recently attention turned veterinary student population qualitative study sought explore veterinary students perceptions experiences university life consider may affect well semi structured interviews conducted students single school purposively selected include perspectives male female graduate entry standard entry straight high school widening participation students across years program three main themes identified deep rooted vocation navigating belongingness finding balance participants described long standing goal becoming veterinarian determination reflected often circuitous routes veterinary school little consideration alternatives although motivated love animals others intrinsically interested scientific problem solving challenges veterinary medicine expressed strong feelings empathy animal owners issue belongingness central participants experiences accounts reflecting efforts negotiate sense belongingness student professional communities participants also frequently expressed degree acceptance poor balance work relaxation indications belief imbalance could rectified later study helps highlight future avenues research supports initiatives aiming nurture sense collegiality among veterinary students progress training profession
one important design problems systolic array processing development systematic methodology transforming algorithm represented high level constructs systolic architecture specified timing data movement interconnection processing elements design requirements satisfied paper method using sfg signal flow graph given algorithm design systolic arrays graphic mapping retiming presented algorithm first represented dependence graph mapped sfg graph projection cut set retiming procedures applied derive regular localised sfg systolic array design obtained given matrix examples decompositions
increasingly frequent intercultural communication influence intercultural pragmatic failures clearly revealed currently many researchers language teachers home abroad conducted researches verbal conduct pragmatic failure often overlooked nonverbal communication pragmatic failure paper focuses types causes nonverbal pragmatic failure intercultural communication puts forward strategy avoid reduce pragmatic failures order provide useful reference people engaging intercultural communication
endocrine disrupting chemicals edcs municipal effluents directly affect sexual development reproductive success fishes indirect effects invertebrate prey fish predators reduced predation prey availability respectively unknown experimental lakes area northwestern ontario canada long term whole lake experiment conducted using control impact design determine direct indirect effects synthetic oestrogen used birth control pill alpha ethynyloestradiol algal microbial zooplankton benthic invertebrate communities showed declines abundance three summers additions indicating direct toxic effects recruitment fathead minnow pimephales promelas failed leading near extirpation species years young year yoy years following adults yoy additions body condition male lake trout salvelinus namaycush male female white sucker catostomus commersonii declined changes prey abundance suggesting direct effects endpoint evidence indirect effects also observed increases zooplankton chaoborus emerging insects observed years additions strongly suggesting indirect effects mediated reduced abundance several small bodied fishes biomass top predator lake trout declined additions probably indirect effect loss prey species fathead minnow slimy sculpin cottus cognatus results demonstrate small scale studies focusing solely direct effects likely underestimate true environmental impacts oestrogens municipal wastewaters provide evidence value whole ecosystem experiments understanding indirect effects edcs aquatic stressors
general strength materials rises increase strain rate ductility decreases however ductility superaustenitic stainless steel increases significantly increase strain rate associated strain induced martensite transformation higher strain rates applied strain induced intersected martensite formed acta materialia inc published elsevier ltd rights reserved
background objective children potentially vulnerable hot ambient temperature however evidence heat related children morbidity still scarce aim examine association temperatures summer may september children hospitalizations two mediterranean cities rome valencia period methods quasi poisson generalised additive models distributed lag non linear models combined study relationship daily mean temperature hospital admissions natural respiratory gastrointestinal diseases children years age associations summarised percentage change admissions percentiles temperature summer compared percentile whole year preceding percentile previous series cumulated risks obtained groups lags showing similar pattern days results almost whatever increase temperature significantly associated increase paediatric hospitalizations natural diseases short term lag small increases high temperatures delayed effect outcome pattern observed rome respiratory admissions valencia delayed association days observed increase temperature percentiles associated short time increase gastrointestinal admissions cities conclusion children hospitalizations rose heat rome valencia patterns delays critical windows exposure mainly varied according outcome considered elsevier inc rights reserved
objective number studies demonstrated anti aggressive properties clozapine schizophrenia positive effect borderline personality disorder published literature treatment antisocial personality disorder aspd clozapine present case series patients primary aspd high psychopathic traits treated clozapine significant history serious violence currently detained based high security hospital methods retrospective review case notes carried formulate clinical global impression cgi scores record incidents violence aggression effect specific symptom domains cognitive perceptual impulsive behavioural dyscontrol affective dysregulation also noted metabolic parameters serum clozapine levels also sampled results patients showed significant improvement clozapine shown benefit symptom domains especially impulsive behavioral dyscontrol anger number violent incidents committed patients reduced significantly patients risk violence reduced clozapine serum levels patients range conclusion clozapine benefit reducing clinical severity aspd improved symptom domains especially impulsive behavioral dyscontrol anger reduced levels aggression violence especially lower doses serum levels knowledge first account clozapine treatment patients aspd high psychopathy
preclinical testing model cancer therapeutics replicates vivo physiology needed accurately describe drug delivery efficacy prior clinical trials develop vitro model breast cancer mimics vivo drug nutrient delivery well physiological size bio composition essential describe mass transport quantitatively objective present study develop vitro computational models measure mass transport perfusion system extracellular matrix ecm perfusion flow bioreactor system used control quantify mass transport macromolecule within ecm hydrogel embedded channels material properties fluid mechanics structure construct quantified vitro model input served validation computational fluid dynamics cfd simulation results showed advection diffusion played complementary role mass transport cfd simulation becomes complex embedded blood vessels cancer cells become recapitulative vivo breast cancers study step toward development preclinical testing platform predictive patient response therapeutics two dimensional cell culture
combine two lines research inventive creative performance separated use empirical models performance inventors careers based established theoretical framework drivers creativity knowledge skills abilities ksao model link survey information spanning inventors entire careers psychometric test evidence patent history data inventors also control variables traditionally used studies inventive performance including inventor age applicant type technology patent time information show educational level skills acquired career personality traits career motivation cognitive ability cognitive problem solving style significantly related inventive performance published elsevier
one major challenges developing growing parabolic trough solar thermal power plants ptstpps enhancing techno economic performance goal study develop unique artificial neural network ann model gives best approach predict levelized cost electricity lcoe two different ptstpps integrated thermal energy storage fuel backup system first one using thermic oil primary heat transfer fluid solar field one based molten salt way optimum designs two plants determined lcoe analysis using obtained weights biases best ann topology techno economic potentials using molten salt comparison thermic oil two optimized plants investigated considering hourly annual performances results show possible get minimum values lcoe cent kwh oil salt configurations respectively moreover difference dispatch thermal energy system solar field aperture area plants annual power generation capacity factor salt plant much higher oil plant difference around elsevier ltd rights reserved
much research focuses causes consequences direct democracy regime legitimacy little attention paid potential relationship attempt fill void paper focuses legal provisions direct democracy use key argument possibilities public direct involvement reflect high importance given citizens openness regime towards different modes decision making ways avoid unpopular institutions consequently citizens likely accept support regime improving maintaining legitimacy cross national analysis includes european countries ranging transition countries established democracies uses bivariate statistical analysis country level data collected legislation secondary sources aggregate surveys
chitosan based magnetite nanocomposites synthesized using versatile ultrasound assisted situ method involving one quick step synthetic route approach results formation spheroidal nanoparticles feo average diameter found superparamagnetic saturation magnetization ranges emu depending concentration incorporation feo chitosan matrix also confirmed ftir techniques hybrid nanocomposite potential application electrochemical sensors since electrochemical signal excepitionally stable addition situ strategy proposed work allowed synthesize nanocomposite system short time around min time consuming showing great potential replace conventional methods herein procedure permit diversity applications nanocomposite materials engineering elsevier ltd rights reserved
purpose purpose paper present swiss cooperative storage facility high bay high density automated oxygen reduced site storage facility serves five research libraries german speaking part switzerland opened february design methodology approach describes complete process evaluating planning innovative facility findings explains way cooperation five libraries highly federalist switzerland achieved principles guided organization libraries prepared holdings site storage shows construction ecologically driven green building economical advantages originality value project seems second automated oxygen reduced library storage facility worldwide british library additional storage buildings depth detail evaluation phase new
objectivethe focus communication study phospholipid structured emulsions whose phase behaviour modified monoalkyl fatty amphiphiles ideally systems would mimic key physical structural attributes observed human stratum corneum better alleviate xerotic skin conditions methodsphosphatidylcholine structured emulsions prepared phase behaviour modified monoalkyl fatty amphiphiles effect molecular volume acyl chain length head group interactions studied using combination physical methods water vapour transmission rate wvtr used primary test assess occlusive character changes vibrational modes observed fourier transform infrared ftir spectroscopy bilayer spacing measured ray diffraction xrd applied elucidate lateral lamellar microstructural characteristics systems resultswater vapour transmission rate demonstrated phosphatidylcholine acyl chain length increased corresponding increase occlusive character addition monoalkyl fatty amphiphiles behenic acid behenyl alcohol cetostearyl alcohol base formulation incorporating dipalmitoyl distearoylphosphatidylcholine seen increase barrier characteristics emulsions ftir methods used probe lipid chain conformational ordering demonstrated phosphatidylcholine acyl chain lengths increased corresponding improvement acyl chain ordering increase thermal transition temperatures addition monoalkyl fatty amphiphile resulted conformational order thermal transition temperature improvements trending towards observed stratum corneum ftir also demonstrated systems containing behenic acid behenyl alcohol exhibited features associated orthorhombic character ray diffraction data showed addition monoalkyl fatty amphiphile also resulted thicker lamellar structures agents present conclusionthe generalized approach described herein shown mechanistically describe occlusive character phospholipid structured formulations presence long chain fatty acids alcohols exhibit characteristics mimicking found human lipids resume objectifl objectif cette communication est etude des emulsions structurees aux phospholipides dont comportement phase est modifie par des amphiphiles gras monoalkyles idealement ces systemes pourraient imiter les attributs physiques structurels cles observes dans stratum corneum humain afin ils puissent mieux alleger les conditions xerotiques peau methodesdes emulsions structurees phosphatidylcholine ont ete preparees leur comportement phase modifies avec des amphiphiles gras monoalkyle les effets volume moleculaire longueur chaine acyle des interactions des tetes ont ete etudies utilisant une combinaison methodes physiques taux transmission vapeur eau wvtr ete utilise comme critere principal pour evaluer caractere occlusif les changements dans les modes vibratoires observes dans transformee fourier infra rouge ftir espacement des bicouches mesure par diffraction des rayons xrd ont ensuite ete utilises pour elucider les micro structures caracteristiques laterales lamellaires dans systems resultatsla wvtr demontre que lorsque longueur chaine acyle phosphatidylcholine est passee puis avait une augmentation correspondante caractere occlusif addition amphiphiles gras monoalkyle tels que acide behenique alcool behenique alcool cetostearylique une formulation base incorporant distearylphosphatidylcholine augmente encore les caracteristiques barriere des emulsions les etudes ftir utilisees pour sonder conformation agencement des chaines lipidiques ont montre que des lors que les longueurs chaine acyle phosphatidylcholine augmentent avait une amelioration correspondante arrangement des chaines acyle conjointement avec une augmentation des temperatures transition thermique addition agent amphiphile gras monoalkyle donne lieu amelioration ordre conformationnel des temperatures transition thermique qui tendent vers ceux observes dans couche cornee ftir egalement demontre que les systemes contenant alcool acide behenique montraient des motifs associes caractere orthorhombique les donnees diffraction rayons ont montre que addition amphiphile gras monoalkyl egalement abouti des structures lamellaires plus epaisses que lorsque ces agents sont pas presents conclusionl approche generale decrite ici illustre caractere occlusif mecanistique des preparations phospholipides structurees presence acides gras des alcools longue chaine ils presentent des caracteristiques qui imitent ceux trouvees dans les lipides couche cornee humaine
abnormal corticostriatal resting state functional connectivity rsfc implicated neuropathology multiple sclerosis striatum component basal ganglia involved diverse functions including movement cognition emotion limbic information processing however brain circuits striatal subregions contributing changes rsfc relapsing remitting multiple sclerosis rrms patients remain unknown used six subdivisions striatum hemisphere seeds investigate rsfc striatal subregions rrms patients matched healthy controls hcs addition also scanned subcohort rrms patients average months test reliability findings compared hcs found significantly increased dorsal caudal putamen dcp connectivity premotor area dorsal lateral prefrontal cortex dlpfc insula precuneus superior parietal lobule significantly increased connectivity superior ventral striatum posterior cingulate cortex pcc rrms patients following scans furthermore found significant associations expanded disability status scale rsfc left dcp dlpfc parietal areas rrms patients results suggest dcp may critical striatal subregion pathophysiology rrms
paper presents first multi vector energy analysis interconnected energy systems great britain ireland systems share common high penetratioh wind power significantly different security supply outlooks ireland heavily dependent gas imports giving significance interconnected aspect methodology addition gas power interactions analysed fully realistic unit commitment economic dispatch model coupled energy flow model gas supply network developed extreme weather events driving increased domestic gas demand low wind power output utilised increase gas supply network stress decreased wind profiles larger impact system security high domestic gas demand however energy system resilient high demand periods gas network stress limited ramping capability localised generating units additionally gas system entry node congestion irish system shown deliver increase short run costs generators gds storage shown reduce impact high demand driven congestion delivering reduction total generation costs period studied reducing electricity imports significantly contributing security supply authors published elsevier ltd
introduction normal circadian rhythm hormones critical patients becomes chaotic causing hormones increase others decrease abnormally goal study evaluate hormonal changes severely ill patients investigate relationship hormonal changes mortality morbidity material methods enrolled patients blood samples collected day day day patient discharged defined days sample drawn day twenty healthy controls included results female patients lower fsh higher prl cortisol levels controls admission intensive care unit icu fsh prl cortisol respectively men significantly low testosterone high prl cortisol levels icu admission prl cortisol respectively lowest levels gonadotropins genders testosterone men measured day cortisol levels decreased patients discharged icu fsh levels increased recovered women fsh mortality rate correlations admission tsh nimv duration apache prl mortality positive correlations apache females prl apache males also displayed conclusions critically ill patients develop significant changes neuroendocrine axes alterations hormones correlate disease severity mortality
aim experiment study sugar weight losses non sugar impurities sugar beet storage coverage containing phase change material pcm combination six coverage types two storage intervals days arranged greenhouse temperature ranging degrees relative humidity paraffin used pcm polyethylene coverages containing paraffin without lamination utilized results showed course days weight sugar losses sugar beet samples without coverage times higher sample coverage containing paraffin days storage amount non protein nitrogen increased respectively sugar beets without coverage compared sugar beets covered paraffin containing film laminated film containing paraffin paraffin containing film respectively lowest degree days covered samples found sugar beets placed inside coverage containing paraffin significant shows technical quality sugar beet depends rate dehydration sugar loss non sugar impurities minimized based covering sugar beet polymeric film containing paraffin recommended
real halfband lowpass complex halfband bandpass filters versatile building blocks multitude dsp applications revisited focus efficient implementation linear phase fir minimum phase iir halfband filters recalled predominatly sample rate alteration computational loads compared optimum signal flow graphs presented comparisons carried corresponding complex halfband filters hilbert transformers passbands centred normalised frequencies omega without additional frequency offset delta omega expected smaller transition width passband stopband higher relative advantage iir approach terms computation yet exist ranges specifications linear phase fir halfband filters outperform minimum phase iir counterparts even without taking account linear phase stability advantages fir filters
paper reports effects teaching tool controls actual robots introductory education computer programming among high school students effects tool investigated means questionnaire following two types experience based programming classes namely one class used actual robots one questionnaire surveys completed classes order determine whether participants level interest information communication technology changed statistical analysis questionnaire results showed use actual robots effective way raise students level interest information communication technology found particularly effective among participants liked subjects science lower level understanding information sciences taught high school
accuracy system simulation hybrid vehicle development key estimating real energy saving expected new technology case claw pole machine becomes challenge integrate simulation platform actual control laws electrical machine self heating impact electrical network combined mapping analytical approach proposed paper accurately estimate claw pole machine behavior alternator motor mode electrical model combines fea method phasor diagram eases integration control laws thermal model real time simulation
face recognition widely used many application areas photo album management information security rapid growth handheld devices social networks bring new challenges face recognition algorithm design system engineering effective handheld device face recognition model must simple lightweight also needs handle large variations background image size etc paper tries address two problems system perspective employ simple linear model face recognition generated svm classifier tell whether pair face subject make classifier generalized well potential inter face intra face variations train billions face pairs many potential problems arise large scale training procedure examples training set large fit single machine computation requirement huge takes many days complete training makes difficult algorithm developers experiment tune model effectively overcome obstacles paper proposes large scale face recognition training system called lfrtrainer system takes advantage massive data parallelism available problem utilizes distributed compute cluster perform model training run system intel endeavor cluster model development tuning year using lfrtrainer train face recognition model embedded devices achieves state art accuracy high scalability face verification rate fvr false accept rate far frgc benchmark nearly linear scalability tens hundreds nodes
paper passive fault tolerant control strategy dedicated air feeding system fault based auto tuning pid regulator designed implemented real fuel cell test bench present work compares auto tuning pid strategy performance classical pid controller highlights benefits faulty operation experimental results demonstrate effectiveness proposed approach regulate oxygen stoichiometry real time operation maintaining proper system performance faulty situations unlike classical pid controller proposed passive fault tolerant control system shows highly satisfactory performance terms setpoint tracking accuracy disturbances rejection capability faulty operations hydrogen energy publications llc published elsevier ltd rights reserved
article argues status women continues major issue ongoing culture wars morality politics scholarly media attention focused abortion gay marriage since democratic republican parties also taken divergent positions status women data american national election studies show general public become supportive equal roles women presidential candidates perceived differ considerably gender roles positions abortion since perceptions candidate differences gender equity strong predictors presidential vote even controlling party identification abortion attitudes religiosity retrospective assessments economy perceived candidate differences issues including abortion
objectives nonsteroidal anti inflammatory drugs nsaid cornerstone treatment axial spondyloarthritis axspa aimed describe real life nsaid use early axspa according disease characteristics methods desir cohort observational study patients presenting inflammatory back pain suggestive axspa less years patients attended visits every months first years yearly years analysed data collected every visit years nsaid intake asas nsaid score months preceding visit reflects full daily intake nsaid results patients assessed males mean age standard deviation years mean symptom duration year mean basdai months preceding inclusion received nsaids proportion significantly decreased time patients years decrease different regard fulfillment asas criteria baseline regard arm asas criteria fulfilled imaging clinical median asas nsaid score interquartile range inclusion substantially decreased reach years although basdai years conclusion nsaid prescription frequent early axspa cohort intake low decreased significantly time even though symptoms remained present early axspa patients may sufficiently treated nsaids societe francaise rhumatologie published elsevier masson sas rights reserved
research regarding stroke indicates short elapsed time accident treatment fundamental allow saving patient life avoid future sequels paper describes model monitoring rescue victims situations possible stroke occurrence uses stroke symptoms monitored mobile equipment ambient intelligence artificial neural networks model independent human operation applications third parties devices therefore adding facilities increase quality life people stroke sequel due constant monitoring follow provided allowing stroke patient consider recovery period greater autonomy prototype based free software platforms developed order assess accuracy time elapsed prototype detect send alert results indicate positive outlook work continuity
study aims characterize psychological wellbeing chronic headache patients identify cortical structural abnormalities associations abnormalities resting state functional connectivity rsfc determine whether rsfc abnormality specific patients compared healthy controls conch patients suffered mild depression sleep disturbances relatively poor quality life patients also exhibited widespread cortical thickness abnormalities left premotor right primary somatosensory right prefrontal cortices well regions default mode executive control networks using cortical regions thickness abnormality seeds found cortical region pairs showed strengthened rsfc patients using seeds rsfc analysis chronic low back pain clbp patients controls conclbp identified abnormalities non overlapping cortical region pairs direct comparison rsfc clbp patients revealed significantly differences thirteen cortical region pairs including four identified conch comparison across three groups clbp con rsfc left multisensory association area left posterior cingulate cortex differed significantly eight regions showed abnormality clbp patients two overlapped patients observations support notion clbp pain pathological conditions brain develops distinct widespread structural functional abnormalities clbp groups share similar structural abnormalities rsfc abnormalities several cortical region pairs appear pathology specific wiley periodicals inc
aimour previous work showed non pharmacological interventions could effectively reduce severity behavioral psychological symptoms dementia bpsd factors influencing effect intervention less explored therefore main purpose present study investigate predictors non pharmacological intervention effect old veterans dementia bpsd methodsa total old veterans dementia living two veterans homes northern taiwan recruited participants received organized non pharmacological intervention program physical activity exercise music therapy reality orientation art therapy reminiscence therapy horticultural therapy every week months participants evaluated barthel index lawton brody instrumental activities daily living scale mini mental state examination neuropsychiatric inventory npi cornell scale depression dementia intervention logistic regression used investigate factors associated improvement maintenance cognition measured mini mental state examination improvement bpsd measured npi subdomains intervention period resultsmultivariate logistic regression analysis showed improvement maintenance cognitive function independently associated lower mini mental state examination score baseline odds ratio whereas participants antipsychotic use less likely gain effect addition improvement bpsd associated higher baseline total npi score result consistent different npi subdomains psychotic domain affective domain behavior domain caregiver burden addition higher cornell scale depression dementia score correlated improvement npi behavior domain whereas participants hearing impairment lower chance improvement npi behavior domain care burden conclusionsour findings show non pharmacological intervention programs significant effect reducing overall npi score npi caregiver burden score npi subdomains psychotic affective behavior syndrome old veterans dementia addition participants lower cognitive performance severe bpsd depressive symptoms baseline likely gain benefit intervention whereas antipsychotic use hearing impairment negative predictors improvement cognition bpsd respectively geriatr gerontol int suppl
nowadays increasing amount waste generated limited landfill space waste disposal recycling one important approaches manage waste effectively current manual recycling practice user need bring waste bulk recycling center might hassle hence become discouraging factor recycle overcome issue project automated recycle bin reward feature proposed derived reverse vending machine rvm concept basically system implemented standard recycle bin provided local municipal equipped microcontroller collection sensors throughout process sensors responsible identifying user information weight scale eventually convert weight corresponding points automatically process completed user claim points using rfid point card mentioned process controlled microcontroller system implemented small scale user testing framework shows effectiveness handling whole process prototype expected aid accelerating motivation among malaysian recycle waste one frameworks overcome urban poverty issue using waste wealth concept authors published elsevier
background hcv genotyping remains critical tool guiding initiation therapy selecting appropriate treatment regimen current commercial genotyping assays may difficulty identifying genotype objective evaluate concordance identifying genotype two methods plus assay core nsb sequencing study design study included plasma serum samples previously genotyped core nsb sequencing samples also previously tested abbott realtime hcv research use ruo assay yielded ambiguous results remaining samples routine genotype genotype genotypes obtained sequence data determined using laboratory developed hcv sequence analysis tool ncbi non redundant database results agreement plus assay core nsb sequencing genotype samples agreement samples respectively plus results agreed core nsb sequencing unselected genotype samples remaining seven detected plus assay among samples ambiguous results concordant plus core nsb sequencing nine detected plus one sample internal control failure conclusions plus assay automated method identifies genotype good agreement gold standard core nsb sequencing aid resolution certain genotype samples ambiguous results elsevier rights reserved
background purpose study characterize risk cancer large cohort patients primary sjogren syndrome sjs methods analyzed development cancer consecutive patients fulfilling sjs classification criteria baseline clinical immunological characteristics systemic activity essdai scores assessed diagnosis predictors cancer using cox proportional hazards regression analysis adjusted age diagnosis gender sex age specific standardized incidence ratios sir cancer estimated spanish mortality data results mean follow months patients developed cancers frequent type cancer cell lymphoma including malt non malt cell lymphomas systemic activity diagnosis primary sjs correlated risk hematological neoplasia cryoglobulins high risk either cell non cell lymphoma subtypes patients cytopenias high risk non malt cell non cell cancer low levels high risk malt lymphomas monoclonal gammopathy low levels high risk non malt lymphomas estimated sir solid cancer hematological cancer sirs specific cancers multiple myeloma immunoproliferative diseases hodgkin lymphoma non hodgkin lymphomas thyroid cancer cancers lip oral cavity stomach cancer conclusions one third cancers developed patients primary sjs cell lymphomas prognostic factors identified sjs diagnosis differed according subtype cell lymphoma developed primary sjs also associated development non hematological cancers thyroid oral cavity stomach
objectivethe receptor pxr key regulatory element neuroinflammatory cascade provides promising target imaging neuroinflammation gsk pxr modulator nanomolar binding affinity high selectivity successfully radiolabeled utilized imaging levels mouse model lipopolysaccharide induced systemic inflammation current study characterized binding profile determined whether gsk detect changes pxr expression rodent model multiple sclerosis methods gsk synthesized high specific activity high radiochemical purity radioligand saturation competition binding assays performed gsk using hek hpxr living cells micro pet studies carried nonhuman primates vitro autoradiography immunohistochemistry studies carried evaluate tracer uptake expression experimental autoimmune encephalomyelitis eae rat lumbar spinal cord eae peak eae remitting stages compared sham rats results gsk binds hek hpxr living cells high binding affinity nmol nmol micro pet studies showed high tracer retention homogeneous distribution brain nonhuman primates eae rat model tracer uptake gsk rat lumbar spinal cord highest eae peak stage psl followed eae remitting stage psl sham psl tracer uptake correlated strongly positive cell counts activated microglia numbers disease severity conclusionwe conclude gsk potential application monitoring neuroinflammation
paper presents system compensate workpiece deformations flexible peripheral milling based piezoelectric actuators dynamic model compensation system formed flexure hinge based worktable moved piezoelectric actuator compensate workpiece deformation induced cutting forces command signal actuator calculated measured cutting forces compensation system acting cutting force values flexible system reach corresponding values rigid model ensuring tool cutting nominal width cut model considers performance three subsystems interact machining process positioning system structural assembly flexible machining process parameter identification dynamic model experimentally obtained modal analysis system identification procedure cutting forces model take account workpiece deformation compensation instantaneous chip thickness width cut proposed compensation system main application machining small parts thin walls although methodology applicable larger parts elsevier ltd rights reserved
space applications data logging sub system often requires compression cope large amounts data well limited storage communication capabilities usage commercial shelf cots hardware components becoming common since particularly suitable meet high performance requirements also cut cost respect space qualified ones side given characteristics space environment usage cots components makes radiation induced soft errors highly probable purpose work analyze set lossless compression algorithms order compare robustness soft errors proposed approach works unhardened version programs aiming estimate intrinsic robustness main contribution work lies investigation possibility performing early comparison different compression algorithms high level considering data structures corresponding program variables approach virtually agnostic downstream implementation details means proposed approach aims perform comparison terms robustness soft errors considered programs final computing platform defined results high level analysis also used collect useful information optimize hardening phase experimental results based openrisc processor reported suggest properly adopted proposed approach makes possible perform comparison set compression algorithms even limited knowledge target computing system
shallow water equations widely used inundation analysis known successful computation floods wide terrains flood propagation buildings urban areas flows around hydraulic structures bridges may satisfy assumptions shallow flow may display markedly dimensional flow characteristics however convenience fast numerical solutions shallow current equations also used flows useful output may obtained study shallow water equations applied flows prominent characteristics results evaluated water depths velocity field horizontal plane calculated satisfactorily surface waves supercritical flow involving shocks described detail however determined flow around several obstacles increases adding faults calculate water depth case uniform flows boundary layer characteristics velocity bed shear stresses predicted successfully using suitable turbulence model
female university students age active sexual life desire delay becoming mothers thus making provision correct timely information contraception crucial study aims investigate level awareness information behaviour contraception among nigerian female university students using simple random sampling select participants university nine colleges federal university agriculture abeokuta nigeria total questionnaires administered duly completed findings showed awareness contraception among respondents known contraceptive methods male condom oral pills injectables respondents first learnt contraception secondary school respondents frequent sources contraception information friends television magazines newspapers preferred sources physicians health workers parents university lectures lecturers major barriers faced seeking information contraception inability get reliable accurate information lack time fear embarrassment measures increase adoption contraception among female students must take cognizance preferred sources information deliver correct adequate information contraceptive methods
inflammatory lung disease one common clinical scenarios yet often poorly understood inflammatory lung disorders chronic obstructive pulmonary diseases causing significant mortality morbidity limited therapeutic options recently new treatments become available pulmonary fibrosis review article describe new insights starting gained positron emission tomography pet methods targeting molecular processes using dedicated radiotracers ultimately aid deriving better pathophysiological classification disorders ultimately result better evaluation novel therapies elsevier ireland ltd rights reserved
darknet monitoring system developed grasp malicious activities internet early stage cope darknet monitoring system consists network sensors deployed widely internet sensors capture incoming unsolicited packets goal system analyzes captured malicious packets provides effective information protecting good internet users malicious activities provide effective reliable information sensors must deployed secret hidden outside hand attackers intend detect sensors evading attempt known localization attacks darknet monitoring systems actual location sensors revealed attackers almost impossible grasp latest tactics used attackers thus previous work proposed packet sampling method samples incoming packets based attribute packets sender increase tolerance localization attack keep high quality information publicized system result almost succeeded counter localization attack generates spike publicized graph detect sensor however cases proposed sampling method works attacker advantage spikes appear clearly graph therefore propose advanced sampling methods sample incoming packets based multiple attributes packets sender paper present improved methods show promising evaluation result obtained simulation
article optimized pid controller fuel cell introduced noted compute pid controller coefficients based trial error method instead imperialist competitive algorithms considered first problem formulated optimization problem solved mentioned algorithm optimized results obtained pid coefficients one important kinds fuel cells called proton exchange membrane fuel cell introduced order control voltage fuel cell changes charges optimal controller introduced based imperialist competitive algorithm order apply algorithm problem written optimization problem includes objectives constraints achieve desirable controller algorithm used problem solving simulations confirm better performance proposed pid controller
holoscopic imaging also known integral imaging true light field imaging system mimics fly eye technique capturing fitll colour spatial images using single aperture holoscopic camera fly eye microlens array view scene slightly different angle adjacent lens records three dimensional information onto two dimensional surface result display must exact optical component reconstruction scene recorded holoscopic image paper proposes innovative holoscopic image resampling method enable replay holoscopic content captured different pixels per lens two different innovative holoscopic image resampling techniques proposed facilitate effective holoscopic content creation manipulating elemental image pixels
call work becoming increasingly common work pattern yet human impacts type work well established given likelihood calls occur outside regular work hours important consider potential impact working call stress physiology sleep aims review collate evaluate evidence effects working call home stress physiology sleep systematic search ebsco host embase web science scopus science direct conducted search terms included call call standby sleep cortisol heart rate adrenaline noradrenaline adrenaline epinephrine norepinephrine epinephrine salivary alpha amylase alpha amylase eight studies met inclusion criteria one study investigating effect working call home stress physiology eight studies investigated effect working call home sleep working call home appears adversely affect sleep quantity cases sleep quality however studies differentiate night call home without calls data examining effect working call home stress physiology sufficient draw meaningful conclusions elsevier ltd rights reserved
ids internet worms great threat network security spread quickly via networks many worms also easily propagate via removable devices become key method worms stealthily invade computers connected internet therefore necessary analyze dynamic behavior containment strategy worms theoretical analysis experiments found traditional constant quarantine strategy quite high demand initial immunization rate difficult achieve real network environments thus pulse quarantine strategy proposed make deficiency constant quarantine pulse quarantine adopts hybrid intrusion detection system ids integrating misuse anomaly ids analyzing systems stability infection free equilibrium basic reproduction number determined basic reproduction number less one system stable beneficial predict worm propagation implement containment strategy otherwise system lose stability worm propagation control numerical analysis given illustrate theory finally simulation experiments presented simulate worm propagation results fully demonstrate correctness theoretical analysis
purpose purpose paper evaluate waste occurrence level construction industry includes first identifying mean value frequency waste occurrence according respondents characteristics second identifying main predictive factors waste occurrence based latent relationships initial waste factors third identifying waste occurrence level indicator woli construction industry based main waste measurement factors design methodology approach total waste factors sorted literature review structured questionnaire adopted carry survey respondents professionals much experience construction management project shapiro wilk test normality levene test anova test factor analysis technique used analyze collected data findings frequency waste occurrence construction projects quite high statistically practically significant difference means waste occurrence selected population categories based factor analysis technique five principal components extracted percent total variance woli construction industry found per scale research limitations implications non probability sampling applied collect data several certain limitations difficulties number data sets relatively small study examined frequency waste occurrence without quantitative information practical implications another study waste factors construction industry different traditional waste studies originality value contribution study practical project management proposed evaluation sheet woli could applied construction firm
purpose investigate therapeutic effects saikosapoin ssd bleomycin blm induced pulmonary fibrosis mice probable mechanisms methods mice prepared intraperitoneal injection blm twenty four hours later mice ssd group administered ssd days injection mice sacrificed blood samples lung tissues collected mice group lung tissues subjected histological examination addition expressions myd traf lung tissue determined western blotting assay serum levels hydroxyproline hyp interleukin interferon ifn measured enzyme linked immunosorbent assay elisa results pathological results showed ssd treatment alleviated alveolitis lung fibrosis lung tissues mice days post blm injection hyp levels mice ssd group significantly lower blm group days post blm injection levels ifn significantly lower compared values blm group day western blotting results revealed expressions myd traf proteins significantly decreased ssd treatment conclusion ssd exerts therapeutic effects blm induced experimental mice via regulation pathway
paper proposes novel surrogate assisted multiobjective evolutionary algorithm based decomposition smoea design electric motors idea improve surrogate gradually optimization simulation results show proposed method outperform regular multi objective optimization algorithm small portion computational cost
invasive fungal infections important cause mortality primarily treated using amphotericin available different formulations conventional lipid based liposomal lipid complex colloidal dispersion intralipid infusion aim study determine efficacy safety conventional amphotericin lipid based formulations systematic review followed pairwise meta analysis performed including randomised controlled trials rcts evaluated use lipid based amphotericin patients degree immunosuppression susceptibility invasive fungal infection electronic search conducted using pubmed scopus web science scielo databases extracted outcomes related efficacy cure safety incidence adverse events results evaluated meta analyses performed twenty three rcts identified participants meta analysis significant differences conventional amphotericin five formulations evaluated observed regard efficacy analysis respect adverse events nephrotoxicity fever chills vomiting lipid formulations presented better profiles conventional formulation present systematic review meta analysis showed conventional amphotericin presents efficacy profile
background surgical lung biopsy slb invasive possible patients undiagnosed interstitial lung disease ild hypothesized transbronchial biopsy tbb findings combined clinical high resolution hrct data leads confident diagnosis congruent slb therefore avoids need slb patients methods evaluated patients investigated suspected ild underwent hrct tbb slb first clinicians radiologists pathologist reviewed clinical information hrct tbb findings clinicians asked provide diagnosis also asked slb needed confident diagnosis subsequently clinical hrct slb data reviewed participants asked provide final diagnosis clinician consensus overall agreement tbb slb based diagnoses calculated results four patients definite usual interstitial pneumonia uip hrct would considered biopsy using current guidelines patients without definitive hrct diagnosis clinicians felt confident diagnosis would recommend slb six cases cases agreement tbb slb diagnoses uip common diagnosis associated hrct diagnosis possible uip nonspecific interstitial pneumonia like agreement poor tbb slb diagnoses confidence tbb diagnosis low conclusions information tbb combined clinical hrct data may provide enough information make confident accurate diagnosis approximately patients ild
objectives wanted explore effects two different low doses mifepristone exposed receptive period human embryo implantation process using well established three dimensional vitro cell culture model specifically developed study process methods vitro three dimensional cell culture model constructed using human endometrial cells isolated endometrium proven fertile women collected cycle day days culture supernumerary human embryos added cultured another days mifepristone vehicle control cultures checked embryo attachment terminated studied expression reported endometrial receptivity markers endometrial constructs using real time polymerase chain reaction results none embryos mifepristone attached endometrial constructs whereas embryos control group attached cultures found studied receptivity markers significantly altered mifepristone exposure similar direction treatment groups significantly differentially expressed treatment groups conclusion report first time exposure low concentration mifepristone receptive period successfully inhibits human embryo implantation process vitro observed dose dependent effect mifepristone endometrial receptivity functional level implication study contributes new knowledge low dose mifepristone short period receptive phase inhibit endometrial receptivity promotes mifepristone contraceptive agent could give women treatment choice avoid unwanted pregnancy high efficacy minimal side effects elsevier inc rights reserved
effective method based measuring fiber orientation yarn floats two dimensional fourier transform fft proposed recognize weave pattern yarn dyed fabric high resolution image recognition process consists four main steps high resolution image reduction fabric image skew correction yarn floats localization yarn floats classification firstly high resolution image reduced nearest interpolation algorithm secondly skew fabric image corrected based hough transform thirdly yarn floats fabric image localized yarns segmentation method based mathematical statistics sub images fourthly high resolution image corrected yarns segmented successively according inspection information reduced image fiber orientations detected fft yarn floats classified means clustering algorithm experimental results discussions demonstrate measuring fiber orientation yarn floats proposed method effective recognize yarn floats weave pattern yarn dyed solid color gray fabrics
majority patients acute febrile jaundice identified yellow fever surveillance program democratic republic congo drc test negative antibodies yellow fever virus however etiological investigation ever carried patients tested hepatitis hav hepatitis hbv hepatitis hcv hepatitis hdv hepatitis hev viruses cause acute febrile jaundice patients included yellow fever surveillance program drc total serum samples collected suspected cases yellow fever january january enzyme linked immunosorbent assay elisa techniques used screen antibodies hav igm hev igm antigens antibodies hbv hbsag anti hepatitis core protein hbc igm respectively hcv hdv viral loads genotypes determined hbv hvd viral hepatitis serological markers diagnosed patients seroprevalences hav hbv hcv hev hbv positive patients also infected hdv median viral loads hbv range hdv range genotypes hbv genotype hdv detected high hepatitis prevalence rates highlight necessity include screening hepatitis viruses yellow fever surveillance program drc
background parenting people intellectual disability attracting increasing attention policymakers service providers require empirical evidence develop sound policy service responses purpose study identify prevalence demographic data parents australia compared parents disabilities population parents without disability method survey disability ageing carers identified suitable survey design weighted analysis performed results estimated australian parents intellectual disability equating parents parents likely child reside outside capital city compared parents without disability conclusions findings provide benchmark data monitoring time prevalence parents point policy service responses parents child outer urban regional rural areas australia
courts united kingdom understanding memory phenomena often assumed matter common sense test assumption respondents consisting chartered clinical psychologists individuals advertised services hypnotherapists hts classified directory yellow pages first year undergraduate psychology students completed questionnaire assessed knowledge memory phenomena broad scientific consensus hts responses inconsistent scientific consensus scoring lowest six ten items principal components analysis indicated two latent variables reflecting beliefs memory quality malleability underlying respondents responses addition respondents asked rate knowledge academic memory literature general significant relationship participants self reported knowledge actual knowledge measured responses item questionnaire evidence beliefs among hts could give rise concern early memories first year life accurately stored retrievable
target detection hard real time task video image processing task recently accomplished feedforward process convolutional neural networks cnn usually accelerated general purpose graphic units gpus however two challenges task one running speed remains improved probably use deeper larger cnn model sophisticated model may trained well due shortage gpu memory paper present two scheduling algorithms solve aforementioned challenges improving system performance holistically first one efficient image combination algorithm used accelerate feedforward process cnn light memory cost algorithm used train arbitrarily large cnn model gpu device limited memory run experiments gtx card use cnn model model parameters larger size global memory gpu compared cudnnv high speedup obtained detection task
three series even odd aliphatic copolyesters poly hexamethylene gluarate hexamethylene pimelate phgp poly hexamethylene pimelate hexamethylene azelate phpa poly hexamethylene gluarate hexamethylene azelate phga firstly synthesized derived even diol hexanediol odd diacids glutaric acid pimelic acid azelaic acid respectively cocrystallization behaviors systematically investigated dsc waxd pom techniques found phgp phpa showed isodimorphism characteristic eutectic behavior observed plot melting point versus composition however phga exhibited strict isomorphism whole composition range without eutectic point waxd studies also confirmed unique isodimorphism isomorphism behaviors even odd copolyesters slight change methylene number alkyl unit comonomers could generate large difference crystallization behavior exhibits unique physicochemical properties structure properties correlations even odd copolyesters furthermore difference cocrystallization miscibility effect comonomers analyzed thermodynamics based defect gibbs energy calculated wendling suter model phgp phpa comonomer units better miscibility case incorporation shorter unit longer unit crystal opposite case contrast case phga units perfectly miscible crystal lattice little difference crystal cell dimensions due identity chain conformation units packing crystal lattice finally model crystal lattice structure copolyesters proposed better understand difference cocrystallization miscibility effect comonomers isodimorphism isomorphism elsevier ltd rights reserved
traditional power control schemes induction heating device mainly focus pulse frequency modulation pfm pulse density modulation solve problems power control efficiency load adaption well paper presents analyzes asymmetrical frequency modulation afm control scheme used full bridge series resonant inverter proposed afm control technique output power controlled two variables operation frequency division factor better efficiency performance achieved medium low output power range compared pfm principles well zero voltage switching condition afm explained power losses switches analyzed control algorithm schedules three control modes afm experimentally verified digital signal processor based induction heating prototype load adaption noise thermal distribution problem switches also analyzed
background suggested asbestos exposure affects lung function even absence asbestos related pulmonary interstitial pleural changes emphysema methods analyzed associations well known asbestos related risk factors individual cumulative asbestos exposure key lung function parameters formerly asbestos exposed power industry workers normal scans excluded participants emphysema fibrosis pleural changes combination results lung function parameters fvc fev dlco airway resistance significantly associated burden smoking bmi years since end exposure dlco however affected factors directly related amount cumulative exposure duration asbestos exposure conclusions results confirm well known correlation lung function smoking habits bmi however found significant association lung function asbestos exposure
video surveillance ambient intelligence applications head pose estimation important challenging task basically problem lies assessing pose head according three reference angles indicate head rotation respect three orthogonal axes named roll yaw pitch angles problem becomes particularly difficult video sequences still images available thus information depth scene missing makes computation pitch angle difficult state art methods usually add information pitch angle separately makes strongly dependent hardware used scene surveillance moreover require large training sets head poses data finally extraction several features detected face often necessary since head pose estimation small part video surveillance system whole necessary find novel approaches make head pose estimation simple possible order allow use real time paper novel method automatic head pose estimation presented based geometrical model relying exploitation vitruvian man proportions related golden ratio approach reduces number features extracted avoiding need training set well information hardware used scene control simple ratios among eyes nose positions according assumed golden ratio used compute particular pitch angle proposed method performs competitively respect state art approaches without requiring working constraints assumptions
paper presents electromagnetic design force calculation compact multiaxis precision positioner six coil single moving part platen moves superimposed concentrated field permanent magnet matrix rectangular coil placed magnetic field generated superimposed concentrated field magnet matrix force acting coil calculated volume integration based lorentz force law distance long sides short sides rectangular coil designed half pitch one pitch magnet matrix respectively allows simplification force generation calculation compact size light mass moving platen six coils divided three two phase linear motor armatures degrees degrees phase differences complete force current relation entire platen six coils derived experimental results presented verify working principle positioner designed paper positioner employed stepping scanning applications require dof planar motions long travel ranges two horizontal directions small rotational motions vertical axis
paper new realization first order voltage mode pass filter apf using grounded capacitor three resistors single current follower non unity gain presented number external resistors proposed apf reduced two considering input intrinsic resistance useful active parameter comparison second generation current conveyor based current follower implementations employing large number metal oxide semiconductor field effect transistors mosfets used composed four mosfets hence favorable low voltage low power circuit design apf designed pole frequency mhz power consumption using ptm level cmos process bsimv parameters voltages spice simulation results included support theory
practice parent child sharing sleeping surface bed sharing one controversial topics parenting research lay literature popularized polarized debate offering one hand claims dangers benefits physical psychological associated bed sharing address scientific evidence behind claims systematically reviewed published papers peer reviewed editorial pieces commentaries topic parent child bed sharing review offers narrative wallcthrough many subdomains bed sharing research including many correlates socioeconomic cultural factors purported risks outcomes sudden infant death syndrome sleep problems found general design limitations lack convincing evidence literature preclude making strong generalizations heat map based eligible studies aids reader visualize world wide prevalence bedasharing highlights need research societies bed sharing norm urge multiple subfields anthropology psychology psychiatry pediatrics come together aim understanding infant sleep nightly proximity parents influences children social emotional physical development elsevier ltd rights reserved
adult maladaptive behaviors including antisocial personality disorder aspd marijuana use major public health concerns present time dearth research showing interrelationships among possible predictors adult maladaptive behaviors aspd marijuana use therefore current study examines pathways adverse family environments late adolescence maladaptive behaviors adulthood participants african americans puerto ricans sixty percent sample female structural equation modeling current study included waves data collection mean ages adverse family environment late adolescence related greater externalizing personality late adolescence turn related greater marijuana use emerging adulthood turn positively associated partner marijuana use young adulthood turn ultimately related maladaptive behaviors adulthood adverse family environment late adolescence also related greater marijuana use emerging adulthood turn associated adverse relationship one partner young adulthood negative partner relationship related maladaptive behaviors adulthood findings suggest family focused interventions kumpfer alvarado psychol dysfunctional families may helpful include entire family
mental health problems implicitly particularly pose questions tensions social world anorexia nervosa bulimia two eating behaviour disorders conceptualised article exposing social tensions particularly affecting young girls frequently middle affluent social classes three structuring characteristics social position female sex comfortable social milieu youth interpretable terms social relations thus closely intertwined syndromes configuration eating disorders atypical among health inequalities usually affect men poorer older groups population sociological examination behavioural disorders shows foundations based excessive conformity norms values would expected girls affluent classes pathological use norms excellence response tensions encountered age
objective study explored compared attitudes student groups trained university portsmouth dental academy upda towards dental interprofessional education ipe methods study population consisted fifth year student dentists king college london dental institute second third year dental hygiene therapy first year dental nursing students upda item validated dentally modified questionnaire readiness inter professional learning scale ripls administered ripls contains three subscales teamwork collaboration professional identity roles responsibilities mean bar standard deviation scores calculated following reversal negative items analyses carried using spss version stata version results overall response rate achieved reference teamwork collaboration groups strongly indicated ipe contribute learning teamwork skills bar improving relationships team members bar however scores differ groups respectively concerning professional identity student dentists significantly higher preference discipline based approach likely agree necessary undergraduate dental dental care professional students learn together perceived clinical problem solving skills learnt effectively students discipline dental hygiene therapy students relation roles responsibilities participants demonstrated strong sense professional role student dentists reported gain knowledge skills dental hygiene therapy dental nursing students dental hygiene therapy students less likely student dentists agree role dental nurses hygienists mainly provide support dentists conclusion findings suggest ipe perceived beneficial relation teamwork however study raises issues regarding professional identity roles educators consider differing perceptions professional roles identities planning delivering interprofessional programmes
use geotextiles geomembranes lining feeder trenches becoming common practice wind solar farms presence rocky soils liner prevents migration bedding trench would create air pockets around cables air pockets act thermal insulators reducing ampacity feeders commercially available software tools suitable modelling thin liner layer around trench bedding important however estimate reduction feeder ampacity presence liners paper presents simplified analytical method estimate reduction feeder ampacity lining used underground cable trenches analytical approach derived calculations presented neher mcgrath validation method carried modeling cable trench using finite elements analysis
remember considerable number personal experiences frequently reminded process known memory reactivation although memory reactivation helps stabilize update memories reactivation may also introduce distortions novel information becomes incorporated memory used functional magnetic resonance imaging fmri investigate neural mechanisms mediating reactivation induced updating memory events experienced museum tour scanning participants shown target photographs reactivate memories museum tour followed novel lure photograph alternate tour later participants presented target lure photographs asked determine whether photographs showed stop visited tour used subsequent memory analysis examine neural recruitment reactivation associated later true false memories predicted quality reactivation determined online ratings subjective recollection would increase subsequent true memories also facilitate incorporation lure photograph thereby increasing subsequent false memories fmri results revealed quality reactivation modulated subsequent true false memories via recruitment left posterior parahippocampal bilateral retrosplenial bilateral posterior inferior parietal cortices however timing neural recruitment way memories reactivated contributed differences whether memory reactivation led distortions data reveal neural mechanisms recruited memory reactivation modify memories subsequently retrieved supporting flexible dynamic aspects memory
consensus single electrodynamic theory yet reached discord seeded century ago abraham minkowski proposed different forms electromagnetic momentum density since expanded scope gradual introduction forms momentum force densities although degenerate sets electrodynamic postulates fashioned comply global energy momentum conservation hope remains isolate single theory based detailed comparison force density predictions radiation pressure experiments comparison two fold challenging handful quantitative radiation pressure measurements past century solutions developed different postulates consist approximate expressions inferential deductions scattered throughout literature reasons appropriate conduct consolidated comprehensive analysis past experiments assumption momentum energy light matter degenerate create combined electrodynamic fluid dynamic simulation testbed uses five historically significant sets electrodynamic postulates including abraham minkowski model radiation pressure diverse configurations minimal assumptions leads new interpretations landmark investigations light momentum including balazs thought experiment jones richards jones leslie measurements radiation pressure submerged mirrors observations laser deformed fluid surfaces experiments optical trapping tractor beaming dielectric particles discuss merits demerits set postulates compared available experimental evidence fundamental conservation laws five sets postulates abraham einstein laub postulates provide greatest consistency observations physically plausible descriptions electrodynamic interactions force density predictions made two postulates unique many conditions experimental isolation potentially within reach
background autism spectrum disorders asd syndromes predominantly defined behavioral features impaired social interactions restricted verbal nonverbal communication repetitive stereotyped behavior past decades reported prevalence asd increased dramatically growth partially explained increased level awareness problem among professionals better diagnostic methods nevertheless underpinning causes asd yet detailed explained suggested rather single causative factor asd pathogenesis influenced environmental genetic factors combination aims review describe environmental risk factors associated asd provide reference basis current future clinical experimental work materials methods basis pubmed search review existing knowledge environmental factors associated asd results series environmental factors repeatedly reported risk factors asd existing studies conclusion air pollution organic toxicants seasonal factors psychological stress migration birth order nutrition may close relationship incidence asd
sonic evidence demonstrates video game experience beneficial effect oil visuospatial cognition contrast evidence indicates video game experience may negatively related cognitive control study examined specificity influence video game experience oil cognitive control participants high low video game experience performed stroop task event related brain potentials recorded behavioral data revealed difference high low gamers stroop interference effect reduction conflict adaptation effect high gamers amplitude medial frontal negativity frontal slow wave attenuated high gamers effect gaining status conflict slow potential data lead suggestion video game experience negative influence proactive reactive cognitive control
synchronization utility voltage naturally carried diode bridge stage single phase active rectifiers active synchronization included control algorithms applied modern bridgeless topologies sensorless line current rebuilding algorithms also need synchronization line voltage compensate least part current estimation error phase locked loop pll circuits employed single phase converters reviewed new digital pll algorithm based synchronous reference frame proposed implemented field programmable gate array utilize parallelism superior time resolution considering restricted frequency variation line voltage around central frequency orthogonal signal obtained discrete differential operator designed ensure unity gain central frequency performance including memory computational cost versus previously consolidated algorithms implemented device analyzed simulations experimental results prove suitable behavior steady state different line frequencies line voltage frequency transients
background information concerning health related quality life hrqol comorbidities adult dermatitis patients stratified loss function mutations filaggrin gene flg limited objective investigate hrqol skin symptoms comorbidities adult flg mutation carriers methods cross sectional study included patients diagnosed atopic dermatitis hand eczema patients completed questionnaires dermatitis skin symptoms hrqol comorbidities including actinic keratosis atopic mental disorders results flg mutations del identified patients significantly associated atopic dermatitis also independently skin fissures fingers heels self reported actinic keratosis although flg mutations significantly associated reducedhrqol measured use dermatology life quality index dlqi association self reported anxiety depression identified notably highest median dlqi score reflecting greater impairment reported patients flg mutations atopic dermatitis overall patients atopic dermatitis flg mutations reported large extremely large impact lives represents twice prevalence seen patients atopic dermatitis wild type flg conclusion patients atopic dermatitis common flg mutations frequently affected reduced hrqol
background amyotrophic lateral sclerosis als rapidly progressive disease nervous system involving upper lower motor neurons patterns structural metabolic brain alterations still unclear several studies using anatomical mri yielded number discrepancies results pet studies investigated effect als cerebral glucose metabolism aim study threefold highlight patterns grey matter atrophy hypometabolism hypermetabolism patients als understand neurobehavioral significance hypermetabolism finally investigate regional differences morphologic functional changes als patients using specially designed voxel based method thirty seven patients als age sex matched healthy individuals underwent structural mri fluorodeoxyglucose fdg pet examinations pet data corrected partial volume effects structural metabolic abnormalities examined als patients compared control subjects using two sample tests statistical parametric mapping spm extracted metabolic values clusters presenting hypermetabolism correlate selected cognitive scores finally atrophy hypometabolism patterns directly compared one paired test spm results found atrophy well hypometabolism motor extra motor regions hypermetabolism medial temporal lobe cerebellum observed negative correlations metabolism right left parahippocampal gyri episodic memory metabolism right temporal pole cognitive theory mind atrophy predominated temporal pole left hippocampus right thalamus hypometabolism predominated single cluster left frontal superior medial cortex conclusions findings provide direct evidence regional variations hierarchy relationships atrophy hypometabolism als moreover fdg pet investigation suggests cerebral hypermetabolism deleterious cognitive function als
online communities become important source knowledge new ideas however little known create compelling virtual experience inspire individuals make novel contributions examination crucial participants time attention become increasingly scarce resources ever crowded online space drawing motivation job design theory develop test research framework examine motivation influenced triggered competition design characteristics drive creativity crowdsourcing communities specifically investigate importance task knowledge design dimensions eliciting levels motivation leading creative efforts additionally consider mediating influence trust driving knowledge contribution behaviour hypothesising suggests trust hosting platform reduces uncertainty fosters knowledge exchange based empirical study kaggle data scientists community reveals intrinsic motivation exerts strong effect participation intention turn positively impacts participant creative efforts highly autonomous competitions special emphasis problem solving require solvers perform variety tasks challenge contestants apply abilities skills leading greater enjoyment sense competence findings provide important implications web platform managers successful management crowdsourcing communities elsevier inc rights reserved
background study evaluated whether vitamin deficiency affects neonatal screening congenital hypothyroidism methods cross sectional study conducted total infants born hospital period thyroid stimulating hormone tsh tested neonates abnormal screening results tsh miu examined two hundred twenty nine called subjects call rate compared randomly selected newborns normal tsh screening among term newborns terms serum tsh free vitamin homocysteine status results called subjects infants infants transient tsh elevation detected normal tsh screening group two infants diagnosed transient tsh elevation mean serum levels positive tsh screening group control group respectively significant difference positive normal tsh screening groups regard serum tsh free serum homocysteine levels conclusions found significant vitamin deficiency positive tsh screening infants beside crucial role vitamin newborns deficiency seems increase recall rates infants program
power production four hydraulically connected microbial fuel cells mfcs compared reactors operated using individual electrical circuits individual four anodes wired together connected four cathodes wired together combined fed batch continuous flow conditions power production different conditions could made based single resistance instead required polarization tests assess individual performance relative combined mfcs based power curves power produced combined mfcs omega summed power omega produced four individual reactors fed batch mode continuous flow four mfcs maximum power produced combined mfcs slightly lower summed maximum power four individual reactors small parasitic current flow adjacent anodes cathodes overall performance relatively unaffected findings demonstrate optimal power production reactors hydraulically electrically connected predicted performance individual reactors elsevier rights reserved
regional temperature quantitative regional cerebral blood flow responses cortical spreading depolarization rat continuously monitored tissue using microfabricated thermal diffusion sensor recalibrates measures cycles regional cerebral blood flow response four phases including early hyperemia peak baseline duration late oligemia minimum duration min temperature rose start regional cerebral blood flow response peak increase degrees returned baseline near start oligemia technology may useful multimodal monitoring laboratory clinic
paper discusses effective contribution learning object teach circuit theory based research conducted students higher education interaction teacher electronics results research pointed features one wants successfully promotes learning perspective work conceived goal development admitting may possible alternative represent models interactions occur within area thereby improving understanding physical concepts particular involved subject electrical circuits also objective characterize learning process series situations replicated leading set behaviors students assumed use tool lead acquiring specific set skills better practice meaningful learning
following review presents synthesis journal articles published represent progress toward better characterizing controlling treating urban stormwater runoff review structured general topical areas related stormwater quality quantity characterization engineered stormwater control treatment practices including erosion sediment control stormwater ponds constructed stormwater wetlands bioretention permeable pavement greenroofs rainwater harvesting systems watershed scale modeling optimization stormwater control treatment practices common research themes emerging collection studies include potential enhance hydrologic pollutant treatment performance stormwater practices via media amendments use innovative outlet control structures well development mechanistic understanding hydrologic water quality functions inform modeling performance predictions studies serve expand field knowledge base inform future efforts improve stormwater control treatment various spatial temporal scales
recent years parallel computing widely employed science research commercial applications parallel systems many core computer clusters inevitable one computing node failures due random errors injected attacks usually diagnosis mechanism able locate several defective nodes number tests analysis test signatures syndromes although covers cases caused random errors sophisticated attacks still able manipulate outputs node masked pass diagnosis therefore paper propose hybrid self diagnosis mechanism adopt new type analysis linear syndromes able locate certain number defective nodes caused random errors addition introduce new type robust analysis non linear syndromes capable detecting attacks undetectable linear syndromes probability close one moreover since hybrid self diagnosis mechanism data level makes little distinction among different operating systems programming languages migrated onto platforms conveniently
enzyme aromatase arom converts testosterone beta estradiol crucial control development central nervous system ontogenesis effects various brain areas mediated estrogen receptor alpha alpha estrogen receptor beta beta fetal development steroids responsible sexual differentiation hypothalamus estrogens also able exert effects brain areas fetus including frontal cortex act estrogen receptors ers modulating cognitive function affective behaviors study determined expression profiles arom ers fetal bovine frontal cortex quantitative real time pcr qrt pcr throughout prenatal development data show patterns expression ers strongly correlated pregnancy increase last stage gestation contrary expression arom correlation ers expression developmentally regulated moreover performed immunochemical studies showing fetal neurons express arom ers arom localized cytoplasm seldom present fine extensions cells alpha detected predominantly soma whereas beta present nucleus cells study provides new data development frontal cortex long gestation mammal large convoluted brain elsevier inc rights reserved
aging associated metabolic diseases type diabetes mellitus cardiovascular disease cancer neurodegeneration aging contributes common processes including metabolic dysfunction dna damage reactive oxygen species generation although glycolysis linked cell growth proliferation mechanisms activation glycolysis aging regulates fibrogenesis lung remain unclear objective study determine glucose transporter glut induced glycolysis regulates age dependent fibrogenesis lung mouse human lung tissues analyzed glut glycolytic markers using immunoblotting glycolytic function measured using seahorse apparatus study effect glut genetic inhibition glut performed short hairpin rna transduction phloretin used pharmacologic inhibition glut glut dependent glycolysis activated aged lung genetic pharmacologic inhibition glut suppressed protein expression smooth muscle actin key cytoskeletal component activated fibroblasts mouse primary lung fibroblast cells moreover demonstrated activation amp activated protein kinase regulated glut dependent glycolysis represents critical metabolic pathway fibroblast activation furthermore demonstrated phloretin potent inhibitor glut significantly inhibited bleomycin induced lung fibrosis vivo results suggest glut dependent glycolysis regulates fibrogenesis aged lung inhibition glut provides potential target therapy age related lung fibrosis
background rate periodontitis population estimated close patients periodontitis especially smoke suffer high rate tooth loss purpose analysis evaluate predictors poor oral health oral health habits among smokers determine trying quit smoking associated better oral health oral health habits smokers united states methods data behavioral risk factor surveillance system brfss used analysis limiting dataset smokers designated exposure respondent report trying quit smoking yes two logistic regression models developed one model identified factors associated recent dental visit longer year survey second model identified factors associated loss six teeth models controlled confounding factors results controlling confounding among smokers brfss trying quit associated significantly lower odds respondents recent dental visit longer year survey odds ratio confidence interval significant risk factor lost six teeth conclusions among smokers united states trying quit associated compliance yearly dental visits higher odds lost teeth future research investigate optimal approaches providing smoking cessation services dental setting
decades person perception research grappled distinction targets actual characteristics substance positively negatively characteristics viewed perceivers evaluation however lack overarching theoretical framework makes difficult establish connections related lines research review relevant literature present test algebraic model incorporates major insights literature model posits person judgments reflect substance evaluation different extents evaluation component reflects interaction item evaluative tone perceiver evaluative attitude regarding target person model may function integrative framework helps improve conceptual clarity cumulative progress person perception research authors published elsevier inc open access article license http creativecommons org licenses
travelling salesman problem tsp well known hard problem difficult efficiently find solution tsp even large number gene instances evolutionary approaches genetic algorithm widely applied explore huge search space tsp however feasibility constraints tsp make difficult devise effective crossover method paper propose improved constructive crossover tsp performance graphics processing units gpus rapidly improves gpu based acceleration increasingly required complex computation problems unfortunately constructive crossover methods easily implemented parallel fashion gene element offspring dependent previous element gene string paper propose effective method large number genes evolve effectively exploiting parallel computing power gpus effective parallel approach genetic tsp crossover methods easily implemented parallel fashion
variants ric gene recently suggested novel cause parkinson disease herein entire ric gene sequenced french canadian french sample series patients unaffected controls effect single variants combined effect variants calculated sequence kernel association tests skat skat done entire gene level different domains exons ric total common rare variants identified patients controls significant association found variant haplotype ric representation ric variants entire gene domain exon levels patients versus controls results support role ric mutations common cause french canadian french populations elsevier inc rights reserved
violence children human rights problem cuts across gender race geographical religious socio economic status cultural boundaries risk violence towards disabled children lifetime three four times greater towards non disabled children starts early childhood severe linked disablist structures society violence perpetrated individuals institutional practices part disabled children everyday life violence often misdiagnosed related individual impairment recognised professionals victims presenting disabled women reflections childhood violence help seeking responses disclosure article seeks raise awareness violence towards disabled girls need recognised serious child protection issue included official definitions child abuse
objective increase level awareness ehlers danlos hypermobility syndrome eds vitamin deficiency associated infantile fragility fractures radiologic features may mistakenly reported caused non accidental trauma due child abuse neglect patients methods constructed case series largest date infants eds vitamin sufficient insufficient deficient infants without eds documented vitamin deficiency radiologic evidence rickets presented multiple fractures originally diagnosed non accidental caused child abuse infants referred outpatient bone health care clinic boston university medical campus year period also present index cases court concluded convincing evidence child abuse infants returned parents institutional review board irb approval obtained results present cases infants multiple fractures diagnosed caused non accidental trauma infants younger one year age among clinical evidence eds family history confirmed clinical diagnosis least one parent eds without evidence eds vitamin deficiency infantile rickets three eds infants diagnosed osteogenesis imperfecta eds overlap syndrome common fractures noted diagnosis ribs extremity fractures including classic metaphyseal lesions serum levels hydroxyvitamin reported infants mothers sixty three percent eds infants serum measured vitamin deficient mean serum level infants vitamin deficiency rickets conclusion eds eds vitamin deficiency infantile rickets associated fragility fractures infants misinterpreted caused non accidental trauma due child abuse
data storage information retrieval important aspects comes development language corpus currently corpora use either relational databases indexed file systems selecting data storage system important facts consider speeds data insertion information retrieval aforementioned two approaches currently various database systems different strengths useful paper compares performance data storage retrieval mechanisms use relational databases graph databases column store databases indexed file systems various steps inserting data corpus retrieving information tries suggest optimal storage architecture language corpus
objective paper perform sensitivity analysis design variables uncertainty analysis daily potable water demand evaluate performance rainwater harvesting systems residential buildings eight cities brazil different rainfall patterns analysed numeric experiment performed means computer simulation rainwater harvesting sensitivity analysis performed using variance based indices identifying important design parameters rainwater harvesting systems assessing potential potable water savings underground tank capacity sizing uncertainty analysis performed different scenarios potable water demand stochastic variations normal distribution different coefficients variation throughout simulated period results shown different design variables potable water demand number occupants rainwater demand roof area important obtaining ideal underground tank capacity estimating potential potable water savings stochastic variations potable water demand caused amplitudes potential potable water savings ideal underground tank capacity average amplitudes quite low cities however combinations parameters resulted large amplitude uncertainty difference uniform distribution tank capacities potential potable water savings stochastic potable water demand generated low uncertainties performance evaluation rainwater harvesting systems therefore uniform distribution could used computer simulation elsevier ltd rights reserved
digital active emi filtering daef technique new direction conductive emi suppression technologies switched mode power converters however conventional daef topology suppresses emi ground ports definitely aim common mode differential mode emi paper novel daef topology proposed flexibly suppress emi also effectively adjust emi suppression ability well prevent interconversion emi hand parasitic parameters circuit time delay controlling system traditional model daef describe system behavior accurately paper proposes precise model daef system model considers passive device parasitic parameters sense circuit injection circuit decoupling circuit also considers time delay digital control system model accurately describe filter performance daef finally simulation experimental results show proposed daef effectively suppress emi moreover precise model predict system filter performance accurately
stimulants caffeine proposed cognitive enhancement healthy subjects study investigated whether performance chess competitive mind game requiring highly complex cognitive skills enhanced methylphenidate modafinil caffeine phase randomized double blind placebo controlled trial male chess players received modafinil methylphenidate caffeine placebo crossover design played twenty minute games two sessions chess program fritz adapted players strength completed several neuropsychological tests marked substance effects observed since three substances significantly increased average reflection time per game compared placebo resulting significantly increased number games lost time three treatments treatment effects chess performance seen games analysed controlling game duration well excluding games lost time modafinil methylphenidate enhanced chess performance demonstrated significantly higher scores remaining games compared placebo conjunction results neuropsychological testing conclude modifying effects stimulants complex cognitive tasks may particular result reflective decision making processes time pressure effects may result enhanced performance yet time constraints reflective decision making may improve even detrimental effects complex task performance elsevier ecnp rights reserved
aftermath natural disaster characterized lack reliable medium dissemination information survivors state art emergency response systems rely satellite radio enabled devices survivors unlike first responders access devices mitigate problem present perpetuu solar powered portable gis microserver microserver node deployed disaster scene serve maps survivors viewable browsers shelf mobile systems perpetuu nodes form wireless mesh cover large geographic region key innovation design perpetuu node tiered software hardware architecture system combines low power micro controller high power micro processor provide large spectrum power states perpetuu stays lowest power state time vitro detect survivors using sensing consequently wake higher power tier disseminate high resolution maps standard web browsers provide directions safe locations tiered design leverages hardware assisted energy measurements wakeup controller balance energy harvested solar panels energy consumed system evaluate perpetuu using measurements prototype trace based simulations show function near perpetually serving maps large number survivors
background non steroid anti inflammatory drug nsaid usage associated kidney injury rise serum creatinine scr often represents irreversible process thus assess early effects regular nsaid use studied sensitive serum urine biomarkers kidney injury methods protocol based intervention study subjects enrolled mutually exclusive groups group included healthy controls minimal baseline nsaid exposure per definition group spondyloarthritis spa patients regular nsaid therapy months group included spa patients minimal nsaid exposure baseline blood urine samples collected groups baseline furthermore group started week regular nsaid therapy blood urine samples collected weeks baseline normal kidney function per definition ensured subjects creatinine neutrophil gelatinase associated lipocalin ngal kidney injury molecule kim cystatin microalbumin measured urine serum samples assess kidney injury results kidney injury biomarkers fold higher spa patients using regular nsaid therapy compared healthy controls spa patients minimal nsaid exposure ukim ungal skim sngal difference scr estimated glomerular filtration rate using cockcroft gault equation groups spa patients started weeks regular nsaid group biomarker levels started rising week showed significant rise week levels patients stopped nsaid use weeks showed reversibility weeks conclusions regular nsaid use spa patients induces subclinical kidney injury represented rise biomarkers levels start rising early days regular nsaid use reversible stopping drug karger basel
categorization plays fundamental role organizing daily interactions social world however increasing recognition social categorization often complex category membership ambiguous multiracial transgender identities different categorical identities race gender may interact determine meaning category membership complex identities simultaneously impact social perceivers impressions social targets experiences identity thereby shaping perceptions experiences interactions fundamental ways review examines recent research perception experience complex multifaceted identities complicate enrich lives although research historically tended focus difficulties challenges associated multiple identities increasing attention paid opportunities emerge possession identities include multiple distinct overlapping groups consider opportunities might benefit perceivers targets
soil evaporation important component water balance irrigated agriculture mulching effective technique reduce soil evaporation efficiency depends meteorological conditions characteristics different mulching materials objective work assess effectiveness inorganic plastic organic pine bark vine pruning residues geotextile wheat straw mulching materials soil evaporation control energy limited falling rate evaporation stages soil evaporation rates quantified consecutive weighings initially wet soils placed trays laboratory microlysimeters field depended meteorological experimental conditions stage evaporation type mulching material falling rate stage ers decreased linearly decreases gwc long drying periods ers low similar among treatments implying soil mulching ineffective soil evaporation control low frequency irrigation systems energy limited stage mulching materials decreased ers relation bare soil plastic vine residues pine bark materials lower ers rest mulching materials materials therefore recommended soil evaporation control high frequency irrigation systems soil surface remains wet time elsevier rights reserved
anatase tio crystal facets garnering increasing attention due unique surface property however specific linear relationship derived facet exposed tio surface adsorption capacity well photocatalytic performance study systematically explored facet effects antimony adsorption photocatalytic oxidation using high index low index tio results suggest high index tio exhibits best iii adsorption photocatalytic activity compared low index tio iii adsorption density amount generated solution correlated magnitude surface energy tio facets photocatalytically generated responsible iii photooxidation evidenced radical trapping experiments great contribution observed low index tio phenomenon found attributable high surface energy enables generation large amount photogeneration compensate fast rate dissipation therefore predominant participation iii photooxidation possible high index tio resulted enhanced photocatalytic rate hand dominated iii photocatalytic oxidation low index tio intrinsic facet dependent adsorption photocatalytic mechanism obtained study would useful developing tio based environmental technologies elsevier inc rights reserved
objective purpose study better understand experience calores hot flashes state campeche mexico characteristics women lives study carried understand sociocultural context women lives conducting larger semistructured survey communities methods eighty five women rural urban settings participated open ended interviews menopausal transition particular attention hot flashes univariate logistic regression analyses identified potential determinants hot flashes qualitative responses analyzed central themes women experienced calores associated menopause time interview results word calores used describe variety sensations experiences related hot climate infections going air conditioning emotional stress physical exertion well symptom associated menopause quantitative analyses likelihood experiencing hot flashes varied menopause status rural urban residence qualitative analyses themes characterized lives women hot flashes follows search availability biomedical care presence absence networks social support marital status quality relationship occupational stress conclusions hot flash questionnaires elicit different symptom frequencies depending language used sociocultural context women lives qualitative findings suggest themes likely influence perception experience hot flashes campeche biomedicine social support marriage stress
describe gravid year old chinese lady known triple positive primary antiphospholipid syndrome previous recurrent deep vein thrombosis early spontaneous miscarriages managed low molecular weight heparin aspirin hydroxychloroquine prednisolone monthly intravenous immunoglobulin presented recurrent per vaginal bleeding weeks gestation found abruptio placentae anti coagulation held subsequently delivered stillborn weeks anti coagulation restarted day post delivery developed hellp hemolytic anaemia haptoglobin ldh elevated transaminases ast alt thrombocytopenia platelet boolean also episodes acute severe headache abdominal pain assessed secondary microvascular ischemia reveal thrombosis blood pressure hovered persistently systolic mmhg required least three anti hypertensives coupled new onset proteinuria day evidence disseminated intravascular coagulation assessed microangiopathic antiphospholipid syndrome started plasmapheresis day post partum patient complained foul smelling vaginal discharge found retained products conception immediately evacuated course followed poly microbial sepsis secondary enterococcus fecalis klebsiella pneumoniae escherichia coli patient treated imipenem completed eight exchanges plasmapheresis followed five days intravenous immunoglobulins good clinical biochemical improvement
osteoporotic fractures major concern health care elderly female populations early diagnosis patients high risk osteoporotic fractures enhanced introducing second order statistical analysis bone image data using techniques variogram analysis analysis computationally intensive thereby creating impediment introduction imaging machines found common clinical settings paper investigates fast implementation semivariogram algorithm proven effective modeling bone strength interest readers areas computer aided diagnosis quantitative image analysis semivariogram statistical measure spatial distribution data based markov random fields semivariogram analysis computationally intensive algorithm typically seen applications geosciences remote sensing areas recently applications area medical imaging investigated resulting need efficient real time implementation algorithm semivariance gamma defined half expected squared differences pixel values two data locations lag distance due need examine pair pixels image sub image processed base algorithm complexity image window pixels field programmable gate arrays fpgas attractive solution demanding applications due parallel processing capability fpgas also tend operate relatively modest clock rates measured hundreds megahertz paper presents technique fast computation semivariogram using two custom fpga architectures modular architecture approach chosen allow replication processing units allows high throughput due concurrent processing pixel pairs current implementation focused isotropic semivariogram computations algorithm benchmarked using vhdl xilinx xupv lxt development kit utilizes virtex fpga medical image data dxa scans utilized experiments implementation results show significant advantage computational speed attained architectures respect implementation personal computer intel multi core processor
background american thoracic society european respiratory society guidelines single breath diffusing capacity lung carbon monoxide lco recommend weekly biological control test lco simulator detect instrument error drift little published regarding results quality assurance program aim analyze long term stability portable lco instrument methods used new easyone pro system checked accuracy using lco simulator reference gases concentration carbon monoxide helium concentration helium first use large clinical laboratory detect instrument drift healthy woman msc age old baseline tested every week period time results spirometry lco maneuvers done using instrument patients failures daily volume flow checks helium calibration checks performed automatically instrument differences simulator lco measured lco min min concentration concentration respectively results biological control tests mean min coefficient variation lco repeatability min measurements outside min mean alveolar volume coefficient variation inspired volume coefficient variation conclusions measurements lco stable period without need manual recalibration instrument biological control good lco simulator evaluate kind device long term laboratory quality control program
attempts idea generation often produce outputs marked restricted creativity lack originality often due responses tethered recently activated knowledge salient examples current research tested hypothesis implicitly priming creativity results creativity flexibility experiment addressed potential underlying mechanisms might lead effect demonstrated creativity priming leads activation remote opposed close associations target item experiments showed priming creativity using two different procedures leads original ideas generative task well better performance remote association task rat effects occurred independently conscious intention creative well motivational mood states across studies activation creative mindset undermined sources inflexible uncreative responding elsevier inc rights reserved
background contact allergies preservatives formaldehyde methylchloroisothiazolinone mci methylisothiazolinone reported appear together statistically significant level recently revisions concerning patch test preparations mci formaldehyde recommended european baseline series aim investigate number concomitant contact allergies preservatives number concomitant contact allergies preservatives fragrance mixes iii gender differences methods patients testedwith theswedish baseline series period department occupational environmental dermatology malm sweden investigated results patients patch tested baseline series males females contact allergies formaldehyde mci significantly associated associations contact allergy mci fmi formaldehyde fmi well statistically significant conclusion contact allergies formaldehyde mci significantly associated well contact allergies preservatives fragrance allergy males females differ significantly concerning contact allergy fragrances
exploring relationship genetic factors outcome following brain injury received increased attention recent years however studies evaluated influence genes specific sequelae concussion purpose study determine allele apolipoprotein apoe gene influences symptom expression following sports related concussion participants included collegiate athletes underwent neuropsychological testing including completion post concussion symptom scale pcss within months sustaining concussion evaluated within week athletes provided buccal samples analyzed determine make apoe genotype dependent variables included total symptom score four symptom clusters derived pcss mann whitney tests showed higher scores reported athletes allele compared without total symptom score physical cognitive symptom clusters furthermore logistic regression showed allele independently predicted athletes reported physical cognitive symptoms following concussion findings illustrate athletes report greater symptomatology post concussion athletes suggesting genotype may confer risk poorer post concussion outcome jins
morphological histological changes choroid plexus carnegie stage presented based magnetic resonance imaging data histological serial section human embryos kyoto collection human embryos primordium initially detected small lump grew caudally became crescent shaped developed directions dorsal frontal growth also became prominent formed number undulating surfaces irregular bulges three large clusters two deep fissures caudal surface mean volume reached additionally histology different depending regions stages epithelium angioblasts center stroma proliferated proximal region whereas epithelium differentiated lobulated distal region blood vascular system organized histological differentiation mapped reconstructed histological serial sections data suggested correlation morphological information obtained magnetic resonance data sets distribution differentiation help morphological analysis histological findings able categorize specific stages findings useful clinical evaluation development embryonic period anat rec wiley periodicals inc
paper deals solution rectify problem corrosion steel girder bridges problem arises due electrochemical reactions occurring inside structure surface steel reactions result oxidizing steel eventually corroding controlling problem mechanism developed using current parallel wire system mechanism based parallel connection circuit principle current always uses path low resistivity also emphasized use smart material produce current supplied parallel wire system install design parallel wire system control corrosion illustrated paper mechanism used various types steel structures like bridges results increased reliability durability structures
purpose asian immigrant asian american women less likely use oral contraceptives ocs tend rely low efficacy methods contraception contraceptive pattern remains poorly understood part theory driven measurement exists assess psychosocial determinants essential explaining behaviors related use population current study aimed evaluate psychometric properties measure attitudes subjective norms toward use among korean american women first step determine whether measure used population potentially asian ethnic groups methods sample consisted korean immigrant women living new york city theory reasoned action guided development measure assessing attitudes norms psychometric evaluation included item analysis internal consistency estimates reliability construct validity factorial discriminant predictive results item total correlations recommendation cronbach alpha attitudes subjective norms measure respectively exploratory factor analyses revealed four interpretable factors confirmatory factor analyses confirmed factor structures derived exploratory factor analyses fit data well discriminant predictive validity measure also established conclusions study provides support validity reliability measure use determining degree korean immigrant women intend use ocs copyright korean society nursing science published elsevier rights reserved
endmember extraction one important issues hyperspectral image analysis linear mixing model pure pixel assumption number convex geometry based methods developed past decades however traditional methods generally produce unsatisfactory results since require hyperspectral image convex structure exactly case real image scene particle swarm optimization pso algorithm recently employed address endmember extraction problem performance limited premature convergence lower precision standard pso much effort required enhance optimization result address problems study novel quantum behaved particle swarm optimization qpso algorithm proposed hyperspectral endmember extraction notable advantages proposed method include row column coding approach particles designed accelerate optimization process cooperative approach employed update particles individual global best positions order help particles optimization behavior multidimensional search space two kinds objective functions namely maximizing simplex volume formed endmember combination minimizing root mean square error original image remixed image incorporated sequential optimization approach endmember extraction problem makes algorithm robust outliers acceptable time cost extensive experimental results prove qpso able find optimal endmember combination
contrast high resource countries maternal mortality seen increase united states caring pregnant women cardiac arrest may prove uniquely challenging given rarity event coupled physiological changes pregnancy optimization resuscitative efforts warrants special attention described american heart association scientific statement maternal cardiac arrest current recommendations address variety topics ranging basic components chest compressions airway management logistical complexities operational challenges involved maternal cardiac arrest
transportation played significant role energy consumption pollution subsequently caused intense growth greenhouse gas emission efficient sustainable improvement transportation sector elevated concern many nations including malaysia bioethanol alternative renewable energy great potential substitute fossil gasoline internal combustion engine ice although bioethanol widely utilized road transport worldwide production application bioethanol malaysia yet considered presently comprehensive diversity bioethanol research distillation performance emission analysis available worldwide yet study techno economic feasibility bioethanol fuel malaysia condition unavailable thus study concentrated bioethanol production techno economic analysis cassava bioethanol alternative fuel malaysia furthermore current study attempts determine effect bioethanol employment towards energy scenario environmental economy economic analysis determined life cycle cost ktons cassava bioethanol production plant project life time years million usd equivalent usd per litre bioethanol furthermore substituting gasoline fuel bioethanol fuel road transport reduce emissions ktons year case repay carbon debt converting natural forest cassava cropland cassava bioethanol required years cassava bioethanol much cheaper gasoline fuel even taxation subjected bioethanol current production cost thus study serves guideline investigation research bioethanol production subsidy cost limitation factors extensive application bioethanol implemented malaysia authors published elsevier ltd
aim present study describe method setting polylactic acid pla printed surgical guide minimally invasive insertion dental implants using cbct cone beam computed tomography acquisition without occlusal contact cad cam computer aided design computer assisted manufacture software design production testing
wireless sensor networks commonly used critical security tasks intrusion tamper detection must protected based previous research paper present kind routing protocol based node convergence degree trust value named bcdtv focus security routing algorithm design work process including election cluster head establishment cluster collection transmission sensing information wireless sensor networks simulation results show protocol prevent malicious behaviour malicious nodes effectively
background purpose national diabetes education program created steps manage diabetes life steps booklet help patients diabetes learn basics self management care recommendations purpose study explore impact steps participants diabetes management knowledge self efficacy glycemia reduction approaches diabetes comparative effectiveness study grade methods sample adults type diabetes enrolled grade included analysis participants took pretest sent home steps took posttest next visit wilcoxon signed rank test used detect differences knowledge self efficacy scale scores pre posttest conclusions analyses revealed increases participants diabetes management knowledge self efficacy pre posttest participants reported formal previous diabetes education showed statistically significant increase knowledge scores compared previous diabetes education implications practice appropriate relevant diabetes education materials may improve self management knowledge self efficacy among adults type diabetes providers feel confident using steps resource clinical practice
background pelvic organ prolapse downward descent pelvic organs results protrusion vagina uterus often provides additional symptoms patient life already complicated menopause considerable variation presentation depending numerous variables like age ethnicity education symptoms aim present study aims studying various factors governing symptomatology treatment choice women perimenopausal age group uterovaginal prolapse central indian population materials methods prospective study women attending gynaecology outpatient department indira gandhi government medical college nagpur presenting pelvic organ prolapse period years january december studied studied differences sociodemographic factors treatment choices followed period months surgical conservative treatment results total women studied according study risk prolapse increased age increasing parity increasing body mass index bmi duration symptoms ranged months years suffering years younger women likely present earlier opting commonly surgical treatment conclusion need increasing awareness well primary prevention regarding uterovaginal prolapse general population especially perimenopausal age group instrumental early access health care system
research impact ceo personality firm level outcomes ambiguous partly underlying mechanisms remain largely unexplored given individuals strongly influenced firm ceo top management team tmt members study focuses ceo tmt interface salient intervening relationship hypothesize ceo personality traits extraversion openness experience would influence firm performance indirectly tmt behavioral integration tmt teamness using multisource survey data small medium sized firms test find general support mediation model ceo personality traits positively related tmt behavioral integration turn enhances firm performance limitations implications future research also discussed
paper analyze hierarchical cellular system finite queues new handoff calls effect reneging waiting new calls callers impatience effect dropping queued handoff calls callers move handoff area considered besides effect guard channel scheme successfully solve system adopting multidimensional markovian chain using transition probability matrix signal flow graph obtain average new call blocking probability forced termination probability average waiting time queued new handoff caps investigate design parameters buffer sizes guard channel numbers macrocell microcells affect performance hierarchical cellular system results show provision buffering scheme guard channel scheme effectively reduce new call blocking probability forced termination probability hierarchical cellular system effectiveness significant macrocell microcells
introduction life expectancy constantly increasing consequence older men frequently multiple comorbidities seeking treatment benign prostatic hyperplasia given frail health men need extreme attention management efficacious safe treatment strategies general population may adequate evidence acquisition national library medicine database searched relevant articles published article title abstract text reviewed appropriateness relevance articles eligible review evidence synthesis elderly frail antagonists used caution given risk orthosralic hypotension consequent falls cause significant morbidity elderly aris present good safety profile anticholinergics must also prescribed caution given risk aggravating symptoms dementia due central blockage cholinergic neuronal pathways prostatic urethral lift medical device low morbidity valid functional results appear endure time prostatic artery embolization demonstrating good results minimal complication rates laser prostate vaporization enucleation also safe elderly men receiving anticoagulation therapy due excellent hemostatic effect prostatic tissue conclusions urologists familiar safety efficacy profile medical surgical therapy elderly population given inevitable increase older patients observe near future
laparoscopic sleeve gastrectomy lsg gained popularity leading bariatric procedure treatment morbid obesity due rising numbers bariatric surgeries neurologic complications become increasingly recognized aim examine biochemical hormonal factors associated neuropathy post lsg thirty two patients included patients neuropathy neuropathic group patients without neuropathy control group diagnosis made consultant neurologist blood samples taken examine vitamin deficiencies hormones involved neuropathy significant difference bmi groups well excess weight loss percentages post lsg months levels within normal range higher vitamin levels significantly lower values respectively vitamin levels significantly higher copper levels lower significant difference glp response groups data showed post lsg neuropathy associated lower levels vitamin copper plus patients older age vitamin significantly higher toxic levels associated neuropathy difference preoperative bmi excess weight loss percent year glp levels found larger data required validate results
rapid prototyping manufacture technology computer tomography image processing mechanical analyses adopted repair skull defect injury patient inspected spiral data exported digital imaging communications medicine dicom format data processed mimics software eliminate noise gray level registration processing filtered parenchyma data preserved bone data stl files analyzed processed magics put equipment equipment one type stereo lithography apparatus sla laser light spot diameter models analyzed comply patients requirements stereo lithography model emulated mechanical properties shape patient bone titanium alloy plate matched anatomy well reconstructed freeform model accurate within
modern movement architecture employed new materials deal social challenges industrial production today environmental problems challenge resilience natural hazards including climate change one geotextiles employed large landscape ash garbage deposits river sides planting building surfaces possible focus green walls roofs emergency housing including reshaping temporary propping systems green walls allow integrating parcels remaining empty collapse buildings pocket parks earthquake impact becomes urban restructuration occasion special support skeleton earth seeds geotextile green wall installations designed later pattented
background childhood disintegrative disorder cdd rare form autism spectrum disorder asd unknown etiology characterized late onset regression leading significant intellectual disability severe autism although phenotypic differences cdd forms asd unclear neurobiological differences methods pursued multidisciplinary study cdd three comparison groups low functioning asd high functioning asd typically developing individuals performed whole exome sequencing wes copy number variant cnv gene expression analyses cdd subsets cohort non sedated functional magnetic resonance imaging fmri viewing socioemotional faces non socioemotional houses stimuli eye tracking viewing emotional faces results observed potential differences cdd forms asd wes cnv analyses identified one rare novo homozygous hemizygous mother son transmission chrx variants probands shared unaffected sibling controls clearly deleterious variants highly recurrent candidate genes candidate genes found conserved variant position intolerant variation trrap znf kiaa play role may involved transcription using human brainspan transcriptome dataset cdd candidate genes found highly expressed non neocortical regions neocortical regions expression profile similar independent cohort asd probands regression non neocortical regions overlapped identified fmri abnormally hyperactive response viewing faces thalamus cerebellum caudate hippocampus eye tracking analysis showed among individuals asd subjects cdd focused eyes shown pictures faces conclusions given cohort sizes limited rarity cdd challenges conducting non sedated fmri eye tracking subjects asd significant exploratory study designed investigate neurobiological features cdd addition reporting first multimodal analysis cdd combination fmri eye tracking analyses presented first time low functioning individuals asd results suggest differences cdd forms asd neurobiological well clinical level
paper investigate dimensional bogoyavlenskii kadontsev petviashili equation fluid plasma ferromagnetic thin film bell polynomials hirota method symbolic computation one two kink soliton solutions derived backlund transformation lax pair conservation laws presented elastic collisions including oblique parallel unidirectional bidirectional collisions two kink solitons discussed addition relation velocities wave numbers two kink solitons analysed wave numbers upsilon velocities axis increase wave numbers increasing increasing upsilon increase decrease upsilon velocities axis increase increasing decreasing
paper presents design active building block analog signal processing named current controlled differential difference current conveyor ccddcc parasitic resistances terminal controlled input bias current proposed element realized cmos technology displays usability new active element maximum bandwidth voltage current followers around ghz mhz respectively thd obtained around within input range power dissipation ccddcc biased current obtained around power supplies addition grounded capacitor based floating capacitance multiplier current mode multiple input single output miso second order universal analog filters included applications realization grounded capacitor based floating capacitance multiplier employs three ccddccs one grounded capacitor without resistor connections capacitance tuned electronically bias current filter offers simultaneous realization five type standard filter responses quality factor frequency response parameters independently tuned non ideal effects developed structures examined spice simulation results proposed ccddcc applications also presented elsevier gmbh rights reserved
process social development computer information management technology widely applied many fields however aspect network security computer information management technology still facing threat network environment seriously influence healthy development computer information management technology paper significance computer information network security management technology briefly analyzed concrete application computer information management technology network security status analyzed aiming corresponding solution measures shortcomings
automated analysis assessment students programs typically implemented automated program assessment systems apass helpful students instructors modern day computer programming classes mainstream apass employs black box testing approach compares students program outputs instructor prepared outputs common weakness existing apass inflexibility limited capability deal admissible output variants outputs produced acceptable correct programs differ instructor paper proposes robust framework automatically modelling analysing student program output variations based novel hierarchical program output structure called hipos framework assesses student programs means set matching rules tagged hipos produces better verdict correctness also demonstrate capability framework means pilot case study using real student programs
esthesioneuroblastoma rare malignant neoplasm oflactory neuroepithelium usually located olfactory cleft superior nasal cavity ectopic localization esthesioneuroblastoma even rarer usually posed diagnostic dilemma delay diagnosis management report rare case ectopic esthesioneuroblastoma sphenoclivus presentation intermittent unilateral epistaxis intermittent intractable headache without anosmia nasal endoscopy findings showed pulsatile mass anterior face sphenoid sinus extension posteriorly towards clivus region occupying floor sphenoid sinus endonasal transclival endoscopic excision tumour performed involved otorhinolaryngology surgeon neurosurgeon intraoperative navigation imaging frozen section histopathological findings esthesioneuroblastoma due rarity unusual presentation diagnosis ectopic esthesioneuroblastoma difficult misdiagnosed type malignancy therefore histopathological result important confirming type tumour lead next step management
effect triple metal gate tmg performance ambipolar current tmg vertical tunnel field effect transistor triple metal gate tmg tfet investigated using technology computer aided design simulation tmg tfet designed tackle performance well ambipolar current simultaneously modulating tmg parameters work function tmg length critical impacts energy band diagrams channel region tempered current ratio steep average subthreshold slope decade power supply voltage ascribed formation energy barrier channel optimal device parameters found two main flaws conventional single material gate tfet degraded state current ambipolar current successfully controlled adjusting tmg structure
paper presents surrogate model based optimization doubly fed induction generator dfig machine winding design maximizing power yield based site specific wind profile data machine previous operational performance dfig stator rotor windings optimized match maximum efficiency operating conditions rewinding purposes particle swarm optimization based surrogate optimization techniques used conjunction finite element method optimize machine design utilizing limited available information site specific wind profile generator operating conditions response surface method surrogate model developed formulate design objectives constraints besides machine tests efficiency calculations follow ieee standard numerical experimental results validate effectiveness proposed technologies
high speed self excited oscillation pulsed waterjet seopw offers many advantages continuous jets external excited pulsed jets large number practical industrial applications order take better advantage seopws effects area discontinuity nozzle inlet analyzed based previous related research experimentally investigated respect axial pressure oscillations jet driven helmholtz oscillator capable producing effective seopws employed experiment found area discontinuity capacity enhancing peak largely depends inlet pressure standoff distance enhancement decreases increasing inlet pressure happens within small standoff distances compared continuous case area enlargement enhances peak corresponding inlet pressures mpa respectively area contraction turns better one improving peak inlet pressure mpa however inlet pressure mpa enlargement contraction decrease peak moreover area discontinuity influence optimum standoff distance maximum peak appears pressure oscillation amplitude even area discontinuities ability increasing amplitude regardless inlet pressure standoff distance contraction enhances amplitude much enlargement testing inlet pressures addition area discontinuity nearly influence oscillating frequency causes perturbations may affect intensity self excitation amplitude elsevier inc rights reserved
paper seeks present model analysis suspicious claims data healthcare providers use different clustering algorithms application ahp multicriteria method prioritizing identified suspect entities subsequent auditing begin brief overview related works covered application aforementioned techniques investigating suspicious entities context internal auditing healthcare presenting steps construction model discuss results determine application clustering algorithms initial variables resulted automatic detection almost entities initially classified suspect ahp model provided rational criteria effectively objectively ranking entities investigation elsevier rights reserved
present language independent verification framework instantiated operational semantics automatically generate program verifier framework treats operational semantics program correctness specifications reachability rules matching logic patterns uses sound relatively complete reachability logic proof system prove specifications using semantics instantiate framework semantics one academic language kernelc well three recent semantics real world languages java javascript developed independently verification infrastructure evaluate approach empirically show generated program verifiers check automatically full functional correctness challenging heap manipulating programs implementing operations list tree data structures like avl trees first approach turn operational semantics real world languages correct construction automatic verifiers
electrospinning efficient flexible method nanofiber production influenced many systemic process environmental parameters govern electrospun product morphology study systematically investigates influence relative humidity electrospinning process results showed morphology electrospun product shape diameter manipulated precise regulation electrospinning diameter nanofibers correlates rigidity shown control lead manipulation material mechanical properties finally based solution rheological parameter namely phase shift angle able predict loss homogenous nanofiber structure correlation conditions electrospinning research addresses mechanism impact electrospinning process offers background exploit order better control nanomaterial properties alter applicability elsevier rights reserved
automatic test systems continue adopt architectures based synthetic instrumentation modular platforms software eclipsing hardware primary input determining technology insertion cadence scope abstracting test programs sets specific hardware commonly referenced valuable tactic reduce risks obsolescence also requires significant front investment return later determined frequency change systems become increasingly software centric cost optimized development strategy requires bounding technology insertion options evaluating costs associated developing driver measurement layers across options managing costs migrating across application software operating systems function time paper discuss evolving solution space software dominated technology insertion strategies examination underlying compatibility cots components play
polycythaemia vera condition characterized blood hyperviscosity due expansion erythrocyte mass common entity among philadelphia chromosome negative myeloproliferative neoplasms arterial venous thrombotic events leading determinants morbidity mortality impairment quality life due vasomotor symptoms erythromelalgia pruritus disease associated symptoms tiredness fatigue pruritus night sweats vision problems headache concentration loss abdominal discomfort early satiety fever weight loss also present review polycythaemia vera actual updated classification myeloid neoplasms changed diagnostic criteria new second line treatment option jak jak inhibitor ruxolitinib approved patients inadequate response intolerant hydroxyurea represents breakthrough treatment patient population
objective assess personality traits using temperament character inventory tci group previously diagnosed adhd patients population controls investigate impact common comorbid psychiatric disorders personality measures method psychiatric comorbidity assessed mini international neuropsychiatric interview plus personality traits tci results patient group significantly higher scores tci dimensions harm avoidance novelty seeking compared control group however adjusting comorbid anxiety depressive disorder adhd group longer showed higher harm avoidance control group difference novelty seeking patient control groups correlated lifetime diagnosis antisocial personality disorder aspd conclusion important take comorbid psychiatric disorders account investigating personality traits adhd
paper proposes method analog multiplier current feedback operational amplifier used form second order voltage controlled multifunctional filter designed circuit achieved theoretical analysis pspice simulation actual measurement simultaneously realize low pass high pass band pass filter function results show pass band adjusted frequency range input signal used field frequency characteristic analysis harmonic analysis frequency measurement signal detection furthermore shows importance theoretical significance application prospects
background oral contraceptives ocs widely used contraceptive method among women reproductive age united states routine download use health related smartphone applications apps continues increase objective purpose study evaluate utility english language smartphone platform reminder apps currently available download methods june july official internet based mobile app platforms two major smartphone operating systems usdandroid google play store iphone itunes dwere searched birth control pill contraception entered search bar smartphone store apps assessed following cost health care professionals involvement app development reminder mechanisms functionality results unique reminder apps meeting inclusion criteria operate intended downloaded apps functioned without internet connection included pop notifications conclusions certain app features overcome common causes missing alarm hypothetically may minimize likelihood user missing daily pill health care providers inform users potential pitfalls advise reminder app used sole reminder method elsevier inc rights reserved
acoustic device used evaluate internal features defects within tubes determination acoustic impulse response paper concerns methods separating total pressure wave measured device forward backward travelling components facilitates computation acoustic impulse response device comprises tube speaker one end axially instrumented microphones unlike similar works methods presented paper designed applied industrial context allow simple calibration implementation using readily transportable equipment two wave separation algorithms presented first known method improved provide simplified calibration second computationally inexpensive technique adapted improve operational bandwidth techniques critically evaluated using custom built test rig designed simulate realistic tube features defects constrictions holes corrosion demonstrated although inter microphone attenuation accounted second algorithm algorithms function well give similar results concluded added sophistication first method means less affected low frequency interference capable yielding accurate results however practical use evaluation tool benefits including inter microphone attenuation outweighed additional calibration computational requirements finally output wave separation techniques validated showing agreement experimental impulse response measurements obtained theoretically derived acoustic tube simulator published elsevier ltd
effective sequence small interfering rna sirna silencing stat psoriatic keratinocytes kcs screened effects effective sirna combined ultrasonic irradiation sonovue microbubbles expression stat kcs dose time response investigated three chemically synthetic sirnas targeting stat carried lipofectamine transfected kcs effects stat expression detected effective sirna selected subsequent experiments negative controls sirna sirna labeled carried lipofectamine combined ultrasonic irradiation sonovue microbubbles transfected kcs optimal parameters ultrasonic irradiation determined effective sirna carried pofectamine combined ultrasonic irradiation optimal parameters sonovue microbubbles transfected kcs dose time response rna interference determined effect rna interference effective sirna optimal time dose carried lipofectamine combined ultrasonic irradiation sonovue microbubbles lus group compared carried pofectamine group results showed sirna achieved highest silencing efficacy selected parameters ultrasonic irradiation sirna carried lipofectamine combined ultrasonic irradiation sonovue microbubbles could effectively knock stat expression mrna protein levels dose time dependent manners determined nmol maximum downregulation mrna protein transfection lus group achieved highest silencing efficacy concluded sirna carried lipofectamine combined ultrasonic irradiation sonovue microbubbles could effectively knock stat expression psoriatic kcs optimized transfection condition sequence sirna could serve research gene therapy psoriasis
little research examined ways mindfulness associated affect dynamics referring patterns affect fluctuations daily life using ecological momentary assessment ema present study examined associations trait mindfulness several types affect dynamics namely affect variability affect inertia affect switch affect instability three hundred ninety undergraduate students singapore reported current emotions coping styles times per day across days results showed trait mindfulness correlated negatively variability instability inertia negative affect positively negative positive affect switch relationships independent openness habitual reappraisal habitual suppression depression self esteem importantly lower maladaptive coping found mediate relationships study suggests trait mindfulness independently promotes adaptive patterns affective experiences daily life inhibiting maladaptive coping styles
objective evaluate efficacy safety short wave therapy sham intervention management patients knee osteoarthritis methods searched following databases inception october medline central embase physiotherapy evidence database cinahl opengrey studies included randomized controlled trials compared sham intervention patients knee osteoarthritis results calculated via standardized mean difference smd risk ratio continuous variables outcomes well dichotomous variables respectively heterogeneity explored test inverse variance random effects analysis applied studies results eight trials patients met inclusion criteria effect short wave therapy pain found positive smd pain subgroup showed patients received pulse modality achieved clinical improvement smd pain scale female patients decreased smd terms extensor strength short wave therapy superior control group significant difference physical function smd adverse effects significant difference treatment control group conclusion short wave therapy beneficial relieving pain caused knee osteoarthritis pulse modality seems superior continuous modality knee extensor muscle combining isokinetic strength function improved
notwithstanding tremendous research efforts cause alzheimer disease remains elusive curative treatment cholinergic hypothesis presented years ago first major evidence based hypothesis etiology proposed depletion brain acetylcholine primary cause cognitive decline advanced age relied series observations obtained aged animals elderly patients pointed dysfunctions cholinergic basal forebrain similarities cognitive impairments induced anticholinergic drugs found advanced age beneficial effects drugs stimulating cholinergic activity review revisits major results show hypothesis provided drive development anticholinesterase inhibitor based therapies almost exclusively approved treatment use despite transient modest efficacy new ideas improving cholinergic therapies also compared discussed light current revival cholinergic hypothesis basis two sets evidence new animal models refined imagery techniques humans first human animal studies agree detecting signs cholinergic dysfunctions much earlier initially believed second alterations cholinergic system deeply intertwined reactive responses providing brain efficient compensatory mechanisms delay conversion active research field provide new insight development multitherapies incorporating cholinergic manipulation well early biomarkers enabling earlier diagnostics prime importance counteract disease recognized start early adult life wolters kluwer health inc rights reserved
objective caving demanding sport practiced throughout world currently collective data analyzing injury mechanism type austere environments study retrospective analysis caving incidents documented national speleological society nss american caving accidents aca annual publication methods study retrospectively analyzes incident reports collected nss aca victim month year location age gender incident type injury zone body injury type result incident time intervals rescue extracted results total victims identified victims male female ages ranged years old average years greatest number events occurred summer months peaking july common incident leading traumatic injury caver fall also contributing caver fatalities lower extremities commonly injured followed upper extremities head respectively fractures comprised injuries followed lacerations bruise hematoma abrasions sprains strains conclusions majority injuries life threatening however course years documented fatalities similar studies wilderness injuries fractures soft tissue injuries lacerations prominent study general overall precipitating event leading injuries falling leading orthopedic trauma better prepare cave rescue teams attempted describe characteristics caving injuries united states
conserving water resources protecting pollution high importance natural cycle life nitrate one important sources water pollution serious threat aquatic ecosystems due high solubility extraction water costly process providing reliable low cost fast method necessary eliminating pollution study tried determine refining potential capacity eichhornia crassipes removing nitrate water factors initial concentration nitrate contact time absorbent mass presence competing ions sulfate nitrate absorption studied results showed best efficiency nitrate removal optimum condition retention time hours absorbent dose three plants stems occurred addition efficiency nitrate removal presence sulfate ions reduce increasing initial nitrate concentration significant change removal efficiency actually increasing absorbent mass removal time increased process nitrate absorption followed langmuir isotherm however results showed eichhornia crassipes promising plant great functionality used refiner removing nitrate simple efficient low cost method
novel microcontroller based maximum power point tracker mppt circuit small scale stand alone photovoltaic generators pvgs built simulated tested characteristic pvg characterized using five solar radiation dependent parameters two short circuit current open circuit voltage pvgs converter used matching circuit load pvg selecting suitable fixed frequency duty cycle delta converter determined adaptively microcontroller getting feedback instantaneous value output voltage system suitable dynamic static loads therefore system needs two measurements solar radiation intensity feedback output voltage across load fed microcontroller measured solar radiation intensity converted microcontroller percent solar radiation highest ever value solar radiation intensity location fed microcontroller base value system parameters pvc dependent need obtained separately every pvc prototype built reasonable correlation obtained measured simulated results elsevier ltd rights reserved
advances materials engineering electronic circuits sensors signal processing classification techniques allowed computational systems interpret biological quantities recognizing physiological conditions next scientific challenge turn technologies portable wearable even implantable energy efficient prospective application next generation portable electroencephalogram eeg signal processing systems hazard prevention attention demanding activities eeg keeps closest connection preoptic area sleep originated paper methodology assessing alertness level based single eeg channel proposed allowing reduction required hardware computational time algorithms besides portable multi channel based ones two new spectral power based indices gamma delta gamma beta gamma alpha computed eeg rhythms normalized haar discrete wavelet packet transform wpt haar wpt allows precisely resolving brain rhythms packets whilst demanding relatively low computational cost effectiveness proposed indices drowsiness detection evaluated comparison five indices originally proposed multi channel processing statistical wilcoxon signed rank test applied evaluate performance entire set indices evidencing significant changes alert drowsy transitions subjects public database proposed indices presented second significant values respectively elsevier ltd rights reserved
recently graphene foam three dimensional interconnected network produced template directed chemical vapor deposition cvd used prepare composite phase change materials pcms enhanced thermal conductivity however pore size large hundreds micrometers resulting remarkable thermal resistance heat transfer pcm inside large pores strut walls study novel hierarchical hgf obtained filling pores hollow graphene networks hgf used prepare paraffin wax based composite pcm thermal conductivity hgf composite pcm higher composite pcm pure respectively hgf composite pcm also exhibits better shape stability composite pcm negligible change phase change temperature high thermal energy storage density pure good thermal reliability chemical stability cycling times importantly hgf composite pcm allows light driven thermal energy storage high light thermal energy conversion storage efficiency indicating great potential applications solar energy utilization storage
purpose review many phenotypes asthma exist ranging mild asthma onset childhood severe asthma later onset making asthma broad disease different pathologies gender disparity exists asthma prevalence adults women increased asthma prevalence compared men women likely severe asthma later onset asthma compared men review clinical animal studies defined role sex hormones airway inflammation smooth muscle contraction mucus production airway mechanics associated asthma pathogenesis recent findings clinical evidence shows increased asthma symptoms occur females starting puberty compared boys however puberty role sex hormones regulating asthma symptoms menstruation pregnancy menopause clear animal studies shown estrogen increases testosterone decreases mediated airway inflammation females increased mediated airway inflammation compared males females increased phi function compared males however mechanisms driving types allergic inflammation fully elucidated summary overall ovarian hormones increased testosterone decreased airway inflammation asthma mechanisms remain unclear delineating pathways using animal models well women men various phenotypes asthma help determine women asthma take avoid hormonal contraceptives well predict changes asthma symptoms life phases including pregnancy menopause sex hormones dramatically changing
use geotextiles postpone reflective cracks asphalt overlay popular practice researchers eager calculate structural value research study focused issue geotextiles used roads iran twelve sections tehran qom road tested examined construction overlay tests falling weight deflectometer type least twelve tests conducted time data five sections four developing model one evaluating output allowed new mathematical model developed seven remaining sections foreign iranian geotextiles used interlayers mean structural value geotextiles equivalent thick hot mix asphalt overlay iranian sections equivalent economic evaluations based construction costs showed use geotextiles economical iran fuel bitumen subsidies eliminated different geotextile brands brought market country
global climate environment deterioration desertification getting worse phenomenon wind sand flow frequently occurs many areas hangers suspension bridges may suffer impact wind sand flow damaged study riding type hangers four strands commonly used hanger long span suspension bridges taken example investigate influence wind sand flow hangers aerodynamic interference effect occur among four strands action wind sand flow order explore influence wind sand flow hangers wind sand flow field around riding type hangers long span suspension bridge simulated within fluent software basis numerical simulation computational fluid dynamics pressure velocity contour aerostatic coefficients forces produced wind sand flow different wind attack angle volume fractions sand phase analyzed simulation results indicate forces exerted wind sand flow riding type hangers greater forces exerted wind wind wind sand flow field drag lift coefficients front two strands hangers exhibit minor changes increasing wind attack angle whereas back two strands increase first decrease small value volume fraction sand phase insignificant effect drag lift coefficients significant effect force exerted hanger force exerted hangers multiplies volume fraction sand phase multiplies results lay theoretical foundation corrosion fatigue analysis riding type hangers large span suspension bridges action wind sand flow
introduction development monoclonal antibody based biologics targeted inhibition cytokines represent potentially effective treatments patients glucocorticoid refractory eosinophilic asthma phenotype areas covered asthma exhibits marked heterogeneity clinically molecular phenotypic level requiring specifically targeted treatments block key pathways disease becoming apparent significant clinical effects anti cytokine based biologic therapies likely carefully selected patient populations take asthma phenotypes account development reproducible straightforward discriminatory biomarkers may aid identification patients likely benefit treatment expensive interventions narrative review based english language original articles pubmed med line reported significant clinical findings published last two years evidence demonstrating effectiveness otherwise targeting carefully selected patients severe refractory asthma expert commentary use baseline peripheral blood eosinophilia simple reproducible biomarker identify patients particular sub phenotypes asthma guide effective use biologic therapy represents significant step forward
memory unreliable example reading new baby stayed awake night people often misremember new baby cried night brewer similarly hearing bed rest tired people often falsely remember sleep list roediger mcdermott general false memories difficult correct persisting despite warnings additional study opportunities argue errors must first detected corrected consistent argument two experiments showed false memories nearly eliminated conditions facilitated comparisons participants errors corrective feedback immediate trial trial feedback allowed direct comparisons responses correct information however knowledge made error insufficient unless feedback message also contained correct answer rate false memories remained relatively constant one hand nothing special correcting false memories simply labeling error wrong also insufficient correcting memory errors including misremembered facts mistranslations however unlike types errors often benefit spacing afforded delayed feedback false memories require special consideration learners may fail notice errors unless correction conditions specifically highlight
numerical modeling well established tool rock mechanics studies investigating wide range problems implicit methods solving linear equations advantage unconditionally stable explicit methods although limited time step often used limited memory demand scalability parallel computing simple implementation complex boundary conditions numerical modeling explicit elastoplastic dynamics time step limited material density mass scaling techniques used overcome limit significantly reduce computation time often used effect mass time scaling may influence numerical results rarely mentioned publications choosing right scaling technique typically performed trial error knowledge systematic studies addressed mass scaling might affect numerical results paper present results extensive systematic study influence mass time scaling behavior variety rock mechanical models employ finite difference scheme model uniaxial biaxial compression experiments using different mass time scaling factors physical models increasing complexity cohesion weakening frictional strengthening model cwfs also introduce normalized energy ratio assist analyzing mass scaling effects find tested models less sensitive time scaling mass scaling mass scaling higher potential decreasing computational costs however also demonstrate mass scaling may lead quantitatively wrong results care must taken interpreting stress values mass scaling used complicated rock mechanics simulations mass scaling significantly influences stress strain response numerical rocks mass scaling acts artificial hardening agent rock deformation elsevier rights reserved
building simulated amnesia work christianson bylin applied cognitive psychology present research introduces new paradigm scientific study memory childhood sexual abuse information session participants mentally took part abuse victim read account sexual assault year old reading narrative participants randomly assigned one four experimental conditions rehearsed story truthfully truth group left abuse details story omission group lied abuse details indicate abuse occurred commission group recall story session rehearsal group one week later participants returned session asked truthfully recall narrative results indicated relative truthful recall untruthful recall rehearsal session adversely affected memory performance session however untruthful recall resulted better memory rehearsal moreover gender ptsd symptoms depression adult attachment sexual abuse history significantly predicted memory childhood sexual abuse scenario implications theory application discussed
objectives multi atlas fusion promising approach computer assisted segmentation anatomic structures purpose study evaluate accuracy time efficiency multi atlas segmentation estimating spleen volumes clinically acquired computed tomography scans materials methods institutional review board approval obtained identified health insurance portability accountability act compliant abdominal scans subjects recent clinical trial compared five pipelines obtaining splenic volumes pipeline manual segmentation scans pipeline automated segmentation scans pipeline automated segmentation scans manual segmentation outliers rudimentary visual quality check pipelines volumes derived unidimensional measurement craniocaudal spleen length three dimensional splenic index measurements respectively using pipeline results ground truth accuracies pipelines dice similarity coefficient pearson correlation squared percent absolute deviation volume ground truth compared point estimates splenic volume change splenic volume time time cost also compared pipelines results pipeline dominant terms accuracy time cost pearson correlation coefficient average absolute volume deviation time cost minute per scan pipeline yielded best results second best approach pipeline pearson correlation coefficient absolute deviation time cost minute seconds per scan manual segmentation pipeline required minutes per scan conclusion computer automated segmentation approach manual correction outliers generated accurate splenic volumes reasonable time efficiency
osteoporosis related various factors including menopause aging common chronic metabolic bone disease characterized increased bone fragility although seen age groups gender races common caucasians white race older people women aging population longer life span osteoporosis increasingly becoming global epidemic currently estimated million people suffering osteoporosis according recent statistics international osteoporosis foundation worldwide women age years men experience osteoporotic fractures lifetime every fracture sign another impending one osteoporosis clinical manifestations fracture fractures cause important morbidity men particular cause mortality moreover osteoporosis results decreased quality life increased disability adjusted life span big financial burden health insurance systems countries responsible care patients early diagnosis disease fractures occur assessing bone mineral density early treatment osteoporosis prevented therefore increasing awareness among doctors turn facilitates increase awareness normal populace effective preventing epidemic
due intermittent adulatory properties wind energy large scale wind farm connected grid much impact power system different traditional power plants therefore necessary establish effective wind farm model simulate analyze influence wind farms grid well transient characteristics wind turbines grid fault however must first establish effective wtgs model doubly fed vscf wind turbine become mainstream wind turbine model currently article first investigates research progress doubly fed vscf wind turbine describes detailed building process model investigating common wind farm modeling methods pointing problems encountered wams widely used power system makes online parameter identification wind farm model based output characteristics wind farm possible focus interpretation new idea identification based modeling large wind farms realized two concrete methods
consider incompressible homogeneous navier stokes equations torus typically dimension improve previous results morosi pizzocchero approximation solution via expansion powers reynolds number precisely propose approximation technique infinity setting morosi pizzocchero present new applications based python program symbolic computation expansion posteriori analysis approximants constructed way indicates amongst else global existence exact solution reynolds number explicitly computable critical value depending initial datum examples given elsevier ltd rights reserved
literature provides evidence use violent video games increases risk young people develop aggressive cognitions even behaviors aimed verify whether exposure violent video games linked problems aggression sample italian children four questionnaires administered children years age attending primary secondary schools northern italy variables measured externalization quality interpersonal relationships aggression quality coping strategies parental stress participants preferred violent games showed higher scores externalization aggression use violent video games age linked higher levels aggression coping strategies habitual video game weekly consumption participants data confirm role violent video games risk factors problems aggressive behavior externalization childhood early adolescence
honey bees business beekeeping profound economic importance global agricultural production bee populations beekeeping industry experiencing threats sustainability beekeeping industry brings health risks beekeepers living proximity hives wide range potential adverse health outcomes systematic review address gap examining symptomatic adverse health outcomes among beekeepers living proximity hives demonstrate dearth published studies nine unique studies health impacts adverse outcomes included bee venom propolis allergies including anaphylaxis lyme borreliosis associated tick bites beekeeping systemic reactions bee venom allergies associated range risk factors however probability allergic reactions decreased years beekeeping increased clear need greater research adverse health outcomes population nevertheless systematic review demonstrates important health consequences suggests appreciation range consequences relevant appropriate reducing disease burden beekeeping order facilitate greater participation aid maintaining global pollination services food security
microstructural changes thermodynamic cyclic properties total material cost cumulative energy demand ticr fev using commercial ferrovanadium fev investigated substitution fev raises equilibrium hydrogen pressure mpa mpa absorption mpa mpa desorption reversible hydrogen storage capacity determined pressure swing cycles reduced mass mass unsubstituted alloy compared mass mass fev substituted alloy corresponds loss capacity approx samples taking account capacity loss caused fev substitution raw material cost per stored reduced original price unsubstituted alloy cumulative energy demand pure depends number purification steps ferrovanadium shows cumulative energy demand reduced least factor compared high purity vanadium elsevier rights reserved
introduction pei programme african region invested recruitment qualified staff data management developing data management system standards operating systems since revamp polio eradication initiative cater data management support needs region support went beyond polio expanded routine immunization integrated surveillance priority diseases impact polio data management support programmes routine immunization disease surveillance yet fully documented article seeks demonstrate methods reviewed polio data management area work evolved progressively along expansion data management team capacity evolution data management systems initiation afp case based routine immunization case based disease surveillance supplementary immunization activities results idsr improved data availability support ist polio funded data managers collecting countries data management system developed polio team used countries record information related polio sias also interventions time routine immunization data started part polio data management team responsibility number reports received went around first year second year conclusion polio data management helped improve overall vpd idsr routine data management well emergency response region approach polio end game african region would benefit using already set infrastructure public health initiative region authors published elsevier ltd
mobile hotspots made dream ubiquitous internet access come true widespread applications still hindered limited power smart phones address issue propose novel distributed cooperative data transmission scheme energy rechargeable mobile devices particular let mobile phone help nearby client devices connect internet via cellular accessing also let clients replenish mobile hotspot energy via wireless power transfer mathematically formulate mutually beneficial relationship mobile hotspots clients optimization problem objective conducting cooperative wireless data energy transmission maximize system utility resorting methods combinatorics matching theory develop near optimal solution many one matching single mobile hotspot distributed matching strategy general case considering nature data communication characteristic wireless power transfer extensive simulation show proposed distributed solution achieves performance close centralized method outperforms greedy matching strategy classic gale shapley matching strategy different scenarios
finite element method employed machine design well study dynamic behavior coffee plant parts objective study determine geometric physical mechanical properties coffee fruit stem branch system dimensions determined image processing masses volumes measured using weighing machine graduated cylinder respectively modulus elasticity determined compression tension bending mechanical tests fruits stems branches respectively poisson ratio determined using longitudinal transversal deformation fruits stems damping ratio determined decay curves using logarithmic decrement method concluded fruit dimensions mass showed tendency increase mature stage evolution modulus elasticity fruit stems green cherry stage higher values mature stage
parenting behaviors influenced numerous factors including individual family community contexts ecological systems theory suggests systems well interactions among systems coalesce influence parent child relationship multiple ways challenges exist within across systems child abuse neglect occur significant body research delved parsing relative importance neighborhood level versus individual level predictors little known complex ways interactions across ecological systems might enhance hinder parenting behaviors current study seeks fill gap answering following research question interactive effects individual neighborhood poverty risk child maltreatment structural equation modeling used analyze data parents special supplemental nutrition program women infants children wic clinics franklin county ohio living higher poverty neighborhoods associated higher levels maltreatment irrespective individual poverty status corresponding decrease living lower poverty neighborhoods findings suggest individual poverty status neighborhood poverty matter child maltreatment appear compounding effect poor poor neighborhood protective effect poor living nonpoor neighborhood elsevier ltd rights reserved
next generation bistatic microwave intrusion sensor driven recent advances technology taking advantage progress technology sensor infrastructure cost reduced power consumption reduced user experience improved previous generations bistatic microwave sensors utilized analog signal processing filtering next generation bistatic microwave sensor progress semiconductor technology microprocessors taken advantage implementing sophisticated digital signal processing techniques cost effective manner use digital filters gain settings allow remote adjustment detection parameters including detection speed sensitivity advances synthesizers allow narrow channelization units frequency diversity replaces conventional method modulation allowing increased channel options leaves modulation transmitted signal method communicating transmitter receiver
introduction colorectal cancer remains second leading cause cancer death united states new strategies prevent detect treat disease needed receptor guanylate cyclase gucyc tumor suppressor expressed intestinal epithelium emerged promising target areas covered review outlines role gucyc tumorigenesis steps translate gucyc targeting schemes clinic endogenous gucyc activating ligands disappear early tumorigenesis silencing signaling axis enabling transformation pre clinical models support gucyc ligand supplementation novel disease prevention paradigm recent fda approval gucyc ligand linaclotide two synthetic ligands pipeline strategy tested human trials addition primary tumor prevention also review immunotherapies targeting gucyc expressed metastatic lesions platforms using gucyc biomarker detection patient staging expert commentary results first gucyc targeting schemes patients become available coming years identification gucyc ligand loss requirement colorectal tumorigenesis potential change treatment paradigm irreversible disease genetic mutation treatable disease ligand insufficiency
background children always outgrow hen egg allergies early childhood egg yolks less allergenic egg whites performed oral food challenge heated egg yolk slightly contaminated egg white eysew ofc infants allergic hen egg hypothesized eysew ofc results would predict egg allergy natural course methods retrospectively reviewed participants hen egg allergy underwent first eysew ofc months age participants passed first eysew ofc defined eysew tolerant participants failed ofc defined eysew reactive participants passed eysew ofc underwent ofc half heated whole egg ofc participants passed ofc defined heated hen egg tolerant participants failed eysew ofc ofc underwent another ofc least months later compared tolerance heated hen egg months first eysew ofc eysew tolerant eysew reactive participants univariate multivariate logistic regression analyses conducted results included participants median age months range months eysew tolerant eysew reactive months first eysew ofc eysew tolerant eysew reactive participants achieved heated hen egg tolerance univariate logistic regression analyses eysew reactive participants crude odds ratio confidence intervals baseline egg white sige levels crude per ten fold increase greater odds persistent allergy hen egg months first eysew ofc multivariate logistic regression analysis adjustment baseline egg white sige eysew reactive participants greater odds persistent allergy hen egg eysew tolerant participants adjusted conclusions classifying infants allergic hen egg eysew tolerant eysew reactive groups useful determining prognosis
study investigated moderators intervention response fully automated internet based monitoring feedback intervention teatbacle different levels therapist support individuals eating disorder symptoms study part randomized controlled trial comparing four conditions featback featback low intensity weekly therapist support featback high intensity three times week therapist support waiting list total participants completed baseline post intervention assessments outcome measure psychopathology model based recursive partitioning applied baseline levels psychopathology found moderate intervention response specifically terms improvement symptoms anorexia nervosa participants higher baseline levels anorectic psychopathology showed better outcomes waiting list condition featback conditions low high intensity therapist support comparison featback without therapist support terms improvement symptoms bulimia nervosa participants mild moderate bulimic symptoms better outcomes featback conditions compared waiting list thus fully automated internet based intervention without therapist support may particularly suitable improving mild moderate bulimic psychopathology whereas intervention without therapist support may less effective improving severe anorectic psychopathology investigating differential intervention responses important could help optimize delivery dissemination health interventions therapist support turn could help moving toward personalized care elsevier ltd rights reserved
background schizophrenia remains major health problem despite antipsychotic medications patients decrease acute symptoms decrease relapses contribute partial sometimes strong positive response patients chronic symptoms clearbecause double blind randomized placebo controlled trial feasible ethicalis many years initial episode onset antipsychotic treatment medication continued achieve best global outcome designed small clinical study retrospectively perform detailed follow examine antipsychotic medication relates global outcome life satisfaction methods naturalistic study patients chronic schizophrenia examining antipsychotic medication adherence years average onset antipsychotic treatment sample derived patients treated many years physician academic clinic treated community physicians referral academic clinic information gathered medication adherence long term global outcomes based patient ratings blind clinician assessment blind medication data global outcome scale global assessment functioning scale patient rated satisfaction life scale spearman rank order correlations used relate medication adherence global outcomes life satisfaction linear regression models adjusted demographic clinical characteristics results total patients mean age mean years possible medication since onset treatment assessed medication adherence statistically significant predictor better long term global outcomes life satisfaction spearman rank order correlations covariate adjusted linear regressions values poor medication adherence associated poor outcomes often disastrous low life satisfaction variables presence substance use disorders family support explain difference adhered conclusions naturalistic study patients adhered antipsychotic medication better long term global outcomes poor adherence study limitations include potential residual confounding sample provides data consistent recommendation absence clinically important unwanted drug effects like tardive dyskinesia large weight gain continuous long term antipsychotic treatment chronic schizophrenia
design high performance differential difference operational mirrored amplifier presented proposed circuit useful continuous time analog signal processing circuit developed using folded cascode amplifier floating current source several applications including grounded resistor voltage amplifier grounded inductor oscillator circuit presented simulation results ddoma circuit applications given elsevier gmbh rights reserved
nonlinearity used enhance broadband rotating piezoelectric vibration energy harvesting construct proper nonlinear rotating harvester challenging problem engineering applications article presents melnikov theory based method explore broadband mechanism necessary conditions nonlinear rotating piezoelectric vibration energy harvesting system first perturbed state space representation nonlinear rotating energy harvesting system built based dynamic model seen stability unperturbed nonlinear system physical basis achieving broadband low frequency rotating energy harvesting second melnikov function defined derive two necessary conditions homoclinic bifurcation chaotic motions simulations performed identify key parameters effects melnikov conditions including distance rotating frequency excitations seen homoclinic bifurcation chaotic motions occur nonlinear rotating energy harvesting systems single frequency broadband excitations finally experiments carried validate two necessary conditions results demonstrate proposed method provide important guidelines optimally designing nonlinear rotating piezoelectric energy harvesters practice
paper describes main characteristics performance saturated core type fault current limiter fcl rated mva provided asg power systems fcl submitted preliminary laboratory testing installed substation reduce fault current device based open geometry magnetic cores allows reduced size weight magnetic saturation cores obtained means two magnesium diboride mgb magnets numerical model fcl developed validated interaction device power grid investigated details results model also discussed paper
herpes zoster infection common condition elderly immunosuppression involving cellular immunity favors occurrence pain frequent complications occurs people aged years virological diagnosis typical useful diagnosis mainly based clinical data skin care essential limit cutaneous damage antiviral drugs reduce risk postherpetic neuralgia early prescribed within hours rash onset analgesia essential conducted relation evolution vaccination effective way prevent occurrence complications elderly particular post herpetic neuralgia
women born millions primordial follicles gradually decrease increasing age irreversible supply follicles completely exhausts menopause fertility capacity women diminishes parallel aging mechanisms reproductive aging fully understood observed decline brca mediated dna repair aging rat primordial follicles understand age related molecular changes performed microarray gene expression analysis using total rna extracted immature day old aged day old rat primordial follicles results current microarray study revealed fold genes differentially expressed two groups genes regulated genes regulated aged rat primordial follicles compared immature primordial follicle gene ontology pathway analysis differentially expressed genes revealed critical biological function cell cycle oocyte meiosis chromosomal stability transcriptional activity dna replication dna repair affected age considerable difference gene expression profiles may adverse influence oocyte quality data provide information processes may contribute aging age related decline fertility
complement immunodeficiencies excluding hereditary angioedema mannose binding lectin deficiency rare published literature consists largely case reports small series collated data cities across europe provide overview primarily homozygous rather partial genotypes impact management patients recruited esid registry clinical laboratory information collected onto standardized forms analyzed using spss software seventy seven patients aged years identified presented first decade life deficiency defects complement factors found serious invasive infections neisseria meningitidis infections occurred patients terminal pathway defects streptococcus pneumoniae infections occurred patients classical pathway defects physicians likely prescribe antibiotic prophylaxis colleagues continent patients classical pathway defects diagnosis patients suffered serious bacterial infections age patient use prophylactic antibiotics associated subsequent infection risk inflammatory autoimmune diseases seen patients terminal pathway one third patients classical alternative pathway defects clinical phenotypes specific complement immunodeficiencies vary considerably terms predominant bacterial pathogen risk type auto inflammatory disease appreciation phenotypic differences help immunologists specialists diagnosis management rare complex patients
recent years growing interest examining role competence factors contribute sense role competence among social workers present study used occupational competence model ocm basis examining contribution personal dimension mastery self esteem secondary traumatization environmental dimension support systems occupational dimension exposure field family violence social worker subjective sense role competence participants study social workers employed centers prevention family violence shelters victims violence women social service bureaus findings indicate occupational dimension contribution exposure work field family violence contributed significantly two components participants subjective sense role competence general sense role competence task knowledge problem solving personal dimension contribution secondary traumatization mastery sense role competence significant environmental dimension support systems specific contribution managerial support participants sense role competence significant light findings practical recommendations developing sense role competence among social workers provided
background patellofemoral joint osteoarthritis common condition yet information regarding conservative management lacking foot orthoses effective intervention improving pain function younger individuals patellofemoral pain may effective patellofemoral osteoarthritis pilot study seek establish feasibility phase iii randomised controlled trial investigate whether foot orthoses worn prescribed motion controlled footwear superior prescribed motion control footwear alone management patellofemoral osteoarthritis methods design phase pilot clinical trial designed randomized single blind parallel group two arm superiority trial trial recruit participants queensland tasmania australia volunteers aged years must clinical symptoms radiographic evidence patellofemoral osteoarthritis eligible inclusion eligible randomized receive either foot orthoses prescribed motion control shoes prescribed motion control shoes alone worn period months feasibility phase iii clinical trial evaluated assessing factors recruitment rate number eligible participants participant compliance study protocol adverse events drop rate secondary aim study determine completion rates calculate effect sizes patient reported outcome measures knee related symptoms function quality life kinesiophobia self efficacy general mental health physical activity months primary outcomes reported descriptively effect sizes confidence intervals calculated secondary outcome measures data analysed using intention treat principle discussion results pilot trial help determine feasibility phase iii clinical trial investigating whether foot orthoses plus motion control footwear superior motion control footwear alone individuals patellofemoral osteoarthritis phase iii clinical trial help guide footwear foot orthoses recommendations clinical management disorder
type diabetes mellitus common endocrinologic disorder affecting pediatric patients diet regimen adaptations patients diabetes may result focusing diet weight control causes eating disorders often patients diabulimia eating disorder specific patients diabetes characterized limiting skipping insulin dosing well observed diet management insulin treatment withheld body appearence social acceptance issues especially patients whose disease diagnosed adolescence hereby present patient diagnosed diabetes age years skipped insulin doses order control weight subsequently diagnosed diabulimia
fast algorithms computing forward inverse sequency ordered complex hadamard transforms scht sliding window presented first algorithm consists decomposing length inverse scht ischt two length ischts second algorithm calculating values window window one length ischt one length modified ischt mischt implemented two schemes achieve good compromise computation complexity implementation complexity forward scht algorithm obtained transposing signal flow graph ischt proposed algorithms require arithmetic operations thus efficient block based algorithms well based sliding fft sliding dft application sliding ischt transform domain adaptive filtering tdaf also discussed supporting simulation results
honor values articulate gender roles importance reputation maintaining one place society maintaining respect groups one belongs sense honor provides template organizing social interactions hence may functional even among people societies report valuing endorsing honor test prediction honor influences judgment attention activated two experiments using culture situated cognition perspective predicted activating one aspect honor would activate aspects even among individuals much endorse honor values tested predictions among european americans group typically associated honor values study participants randomly assigned experimental control groups differed one way experimental group read statements honor values first step control group participants judged stick figure pairs judging male study made lexical decisions judging whether letter string formed correctly spelled word study study experimental group participants likely choose visually agentic figure male study experimental group participants accurate noticing letter string formed word word honor relevant word noble differ control group word irrelevant honor happy participants studies neutral point endorsement honor values individual differences honor values endorsement moderate effects activating honor mindset though honor often described located space find clear effects letter strings located computer screen findings suggest new way consider honor functions even societies honor highly endorsed value
sexual size dimorphism ssd describing intersexual size differences given taxon widespread phenomenon animal kingdom ssd plays significant role understanding life history mating system evolution snakelike morphology limbless caecilian amphibians lacking obvious secondary sexual characters contrast frogs salamanders impedes accurate comparison sexes phylogenetically derived teresomatan viviparous caecilian geotrypetes seraphini seraphini analysed patterns sexual dimorphism terms body size females larger sex body length adjusted malebiased intersexual differences cloacal shape appeared larger female size likely explained fecundity selection clutch size positively correlated female body length unexpectedly cryptic ontogeny related variation nuchal collars found overview ssd caecilians including data species nine ten existing families revealed quite high number taxa showing sexually dimorphic head size dimensions exclusively present among phylogenetically derived teresomatan caecilians still research including insights behavioural ecology molecular ecology mating systems warranted better understand evolution sexual size dimorphism caecilian amphibians
high concentration photovoltaics equipped high efficiency multijunction solar cells great potential achieving cost effective clean electricity generation utility scale systems complex compared conventional photovoltaics multiphysics effect present modelling power output systems therefore crucial market penetration following line multiphysics modelling procedure high concentration photovoltaics presented work combines open source spectral model single diode electrical model threedimensional finite element thermal model order validate models multiphysics modelling procedure actual data outdoor experimental campaign conducted albuquerque new mexico using high concentration photovoltaic monomodule thoroughly described terms geometry materials experimental results good agreement within predicted maximum power point multiphysics approach relatively complex compared empirical models besides overall performance prediction also provide better understanding physics involved conversion solar irradiance electricity therefore used design optimisation high concentration photovoltaic modules elsevier ltd rights reserved
alfalfa medicago sativa traditionally sown field without ridge furrow rain fed semi arid areas northwest china forage yields normally low drought water loss soil erosion field study conducted determine monthly runoff efficiency threshold rainfall different ridge widths mulched different materials common plastic film bio degradable mulching film manually compacted soil effects different ridge furrow ratios ridge mulching materials soil water storage topsoil temperature forage yields water use efficiency wue alfalfa ridge furrow rainwater harvesting rfrwh system consecutive years average monthly runoff efficiency years bmr bmr bmr cmr cmr cmr bmr cmr ridges manually compacted soil mulched bio degradable mulch film common plastic film respectively subscripts refer ridge widths furrow width respectively treatments threshold rainfall field experiment showed ridge mulching materials ridge widths distinct effects topsoil temperature ridge tops furrow bottoms soil water storage soil depth furrow bottoms increased increasing ridge width order cmr approximate bmr average annual total forage yields bmr cmr respectively years total precipitation years higher average rainfall leading significant decreases forage yields significant increases forage yields bmr cmr compared average forage yields decreased increased bmr bmr bmr cmr cmr cmr respectively years wue bmr cmr times greater years increased decreasing ridge width optimum furrow width cmr bmr rfrwh system width furrows alfalfa production region future study needed investigate optimum ridge furrow ratio suitable ridge mulching material achieving best environmental economic benefit different climatic conditions soil types plant species using bio degradable mulching materials elsevier rights reserved
metabolic dysfunction microvascular abnormality may contribute pathogenesis schizophrenia previous studies cerebral perfusion schizophrenia measured total cerebral blood volume cbv cerebral blood flow cbf brain reflect ensemble signal arteriolar capillary venular compartments microvasculature arterioles actively regulated blood vessels among compartments may sensitive component microvasculature metabolic disturbances study adopted inflow based vascular space occupancy ivaso mri approach investigate alterations volume small arterial pial arteriolar vessels arteriolar cerebral blood volume cbva brain schizophrenia patients ivaso approach extended dimensional whole brain coverage cbva measured brains schizophrenia patients matched controls ultra high magnetic field significant reduction grey matter cbva found multiple areas across whole brain patients relative changes effect sizes cbva values several regions temporal cortex showed significant negative correlations disease duration patients cbva increase also found brain regions results imply microvascular abnormality may play role schizophrenia suggest cbva potential marker disease investigation needed elucidate whether effects due primary vascular impairment secondary causes metabolic dysfunction
paper one new parallel version gpbi method pgpbi method brief proposed solving large sparse linear systems unsymmetrical coefficient matrices distributed parallel environments method reduces three global synchronization points one reconstructing gpbi method communication time required inner product efficiently overlapped computation time vector updates combines elements numerical stability characteristics design parallel algorithms cost slightly increased computation time ignored compared reduction communication time performance isoefficiency analysis shows pgpbi method better parallelism scalability gpbi method numerical experiments show scalability improved factor improvement parallel communication performance approaches
paper efficient recursive formulation suggested systolic implementation canonical basis finite field multiplication based irreducible aop derived recursive algorithm multiplication used design regular localized bit level dependence graph systolic computation bit level regular converted fine grained node splitting mapped parallel systolic architecture unlike existing structures involve global communications modular reduction proposed bit parallel systolic structure cycle time best existing bit parallel systolic structure involves significantly less number registers proposed bit parallel design scalable latency log cycles considerably low compared existing systolic designs moreover proposed time multiplexed structure designed specifically scalability throughput hardware complexity meet area time trade resource constrained applications maintaining reducing overall latency asic synthesis report shows proposed bit parallel structures offers nearly saving area nearly saving power consumption best existing aop based systolic finite field multiplier
alarm management fast growing important aspect petroleum operation domain alarm devices become cheap leading petroleum equipment manufacturers overuse transferring safety responsibility operators rarely accident reports cite poor operators understanding actual plant status due many active alarms typical alarms process plant could average fourteen thousand per day mandatory filtering process distinguish expected non expected behavior emergency scenarios ambient intelligence contributes enriching petroleum plant environment technology mainly sensors devices interconnected network built system help plant operators make decisions based real time information gathered historical data accumulated ambient intelligence puts together resources provide flexible intelligent services users acting environment inspired distributed encapsulated aspect process plant artifact physical model proposed multi agent based alarm management system synthesize process plant situation emergency situations assisting operators make sense alarm avalanche scenarios
paper try present comparative study non relational databases relational databases mainly focus presentation one implementation nosql database technology namely mongodb make comparison another implementation relational databases namely mysql thus justifying mongodb efficient mysql also present advantages using non relational database compared relational database integrated forum field personal professional development nosql database used develop forum mongodb chosen variety non relational databases thanks aspects highlight article database integration framework also presented
objectivesunfulfilled basic psychological needs associated disordered eating behaviours mechanisms underlying associations well understood study examined two stage path model linking basic psychological need satisfaction disordered eating behaviours via issues control methodsfemale university students age community participants age women self reported diagnosed eating disorder age completed measures psychological need satisfaction autonomy competence issues control feelings ineffectiveness fear losing self control flc pathology resultspath analysis revealed unsatisfied needs autonomy competence indirectly related disordered eating behaviours feelings ineffectiveness flc conclusionsthe results indicate issues control might one mechanisms lack psychological need satisfaction associated disordered eating although model constructed using cross sectional data findings suggest potential targets prevention treatment efforts aimed reducing disordered eating young females practitioner points results indicate young women chronically unfulfilled basic psychological needs might vulnerable developing disordered eating behaviours observed patterns suggest persistent experience need frustration may engender internal sense ineffectiveness lack control compels individuals engage disordered eating behaviours attempt regain autonomy competence interventions eating disorders may effective emphasizing promotion people needs autonomy competence limitations model constructed using cross sectional data future experimental longitudinal studies needed confirm temporal sequence basic psychological needs issues control sample consisted young women research explore thwarting psychological need satisfaction functions men clinical sample small diagnosis confirmed clinical interview therefore data interpreted caution
group dynamics play important role social interactions children adults large amount research shown merely allocated arbitrarily defined groups evoke disproportionately positive attitudes toward one group negative attitudes toward groups biases emerge early childhood prompts important empirical questions far reaching theoretical applied significance robust inter group biases biases mitigated behaviors known bond individuals groups together bonds forged across existing group divides explore questions examined bonding effects interpersonal synchrony minimally constructed groups controlled experiment group group bonding assessed using questionnaires administered task groups performed movements either synchronously non synchronously participants design also developed implicit behavioral measure island game physical proximity used indirect measure interpersonal closeness self report behavioral measures showed increased bonding groups synchronous movement bonding group significantly higher condition movements performed synchronously movements performed non synchronously groups findings discussed terms importance developmental social psychology group dynamics well implications applied intervention programs
insulin pump users worldwide depend insulin infusion sets iiss predictable delivery insulin subcutaneous tissue yet emerging data indicates iiss associated many pump related adverse events may contribute potentially life threatening problem unexplained hyperglycemia relative scarcity published research iiss date heterogeneity regional iis practices increasing demand international standards guiding use prompted convening panel diabetologists diabetes nurse educators last february milan italy discuss framework optimizing iis practice europe multinational panel tasked first identifying often overlooked iis issues affect patients experience pump therapy partial complete blockage cannula skin pathologies unpredictable variations insulin absorption dislodgment demands site rotation set changes second establishing direction developing cohesive protocols assure long term success reported article panel examined iis related complications pump therapy encountered clinical practice considered country wide policies prevent mitigate complications updated priorities improving iis education issues device selection skin care troubleshooting unexplained hyperglycemia recommendations may relevant possibility closed loop systems available near future
traction application electric motor design methodology trivial paper presents design approach using rated point based finite element model design optimization double sided linear induction motor achieved using efficient global optimization algorithm
nickel alloys containing optimum amounts chromium molybdenum tungsten widely used chemical processing industries due tolerance oxidizing reducing conditions unlike stainless steel alloys exhibit remarkably high uniform corrosion resistance major concentrated acids like hydrochloric acid hcl sulfuric acid hso higher uniform corrosion resistance alloys compared alloys concentrated acids attributed formation protective oxide film reducing acids oxide film oxidizing solutions localized corrosion resistance alloys containing high amount well also significantly higher commercially available alloys present study investigates role alloying elements nickel alloys uniform corrosion resistance concentrated acids hcl hcl oxidizing impurities hso localized corrosion performance chloride rich environments using astm test methodology corrosion tests conducted various alloys results analyzed using weight loss technique electrochemical techniques conjunction surface characterization tools
dopamine neurotransmitter chemical messenger plays vivacious role number significant medical conditions like parkinson disease attention deficit hyperactivity disorder schizophrenia drug addiction turn sensors superior level selectivity fluorescence quenching based sensors developed fluorescence retrieval strategy dopamine sensing highly fluorescent amino phenyl boronic acid apba aeuro conjugated gold nanocluster auaeuro bsaaeuro apba probe synthesised bovine serum albuminaeuro protected gold nanocluster auaeuro bsa ncs boronic acid forms boronate ester disaccharides lactose due affinity polyols hence fluorescence auaeuro bsaaeuro apba probe quenched binds lactose molecules boronate ester formation fluorescence auaeuro bsaaeuro apbaaeuro lactose system retrieved turn dopamine competitive displacement lactose probe surface suggests higher affinity boronic acid catechol group dopamine furthermore real samples spiked dopamine including human serum urine analysed using turn sensor showed excellent recovery percentage developed fluorescent sensor offered high selectivity dopamine catecholamines aminoacids detection limit low
adipose tissue possesses crucial immunological features development comorbidities obesity complex interactions metabolic system cells immune system cause fully understood autoimmune diseases might therefore influenced obesity epidemiological studies provide evidence modest association obesity development rheumatoid arthritis psoriatic arthritis obesity course inflammatory rheumatic diseases aggravated subjectively measured activity parameters however laboratory parameters show differences radiographic examinations reveal less bone destruction obesity furthermore indications poorer response treatment especially infliximab patients increased body mass index bmi weight loss positive effect course joint diseases due deficits currently available studies insufficient evidence recommend individualization treatment decisions based bmi
purpose review review pathways cytokines concepts important pathogenesis bone resorption formation rheumatoid arthritis spondyloarthritis spa recent findings research bone biology shed light pathogenesis joint destruction occurs peripheral spa however understanding mechanisms behind bone formation seen peripheral axial spa challenging mouse models used gain understanding key signaling pathways cytokines cells regulating inflammation diseases biologic therapies directed targets developed control inflammation effects bone summary although biologic therapies improve joint inflammation spa leading decrease pain improving quality life patients long term effects therapies must also evaluated assessing impact structural progression inhibition radiographic progression peripheral spa easier demonstrate axial spa discuss similarities differences among biologic therapies pertain radiographic progression
pulmonary hypertension serious disorder high morbidity mortality rate known occur number unrelated systemic diseases several hematological disorders sickle cell disease thalassemia myeloproliferative diseases develop worsens prognosis associated oxidant injury vascular inflammation cause endothelial damage dysfunction pulmonary vascular endothelial damage dysfunction early event resulting loss vascular reactivity activation proliferative antiapoptotic pathways leading vascular remodeling elevated pulmonary artery pressure right ventricular hypertrophy premature death hemolysis observed hematological disorders leads free hemoglobin rapidly scavenges nitric oxide limiting bioavailability leading endothelial dysfunction addition hemolysis releases arginase circulation converts arginine ornithine thus bypassing production furthermore treatments hematological disorders immunosuppressive therapy splenectomy bone marrow transplantation radiation shown contribute development recent studies shown deregulated iron homeostasis patients cardiopulmonary diseases including pulmonary arterial hypertension pah several studies reported low iron levels patients idiopathic pah iron deficiency important risk factor article reviews associated hematological disorders mechanism iron homeostasis relevance
background spite availability effective treatments obsessive compulsive disorder ocd many patients respond sufficiently relapse treatments using potentially effective methods experiential techniques need investigated developed week inpatient treatment augmenting exposure response prevention erp schema therapy called sterp feasibility effectiveness sterp tested methods pilot study inpatients ocd failed respond cognitive behavioral therapy cbt erp received sterp yale brown obsessive compulsive scale bocs served primary outcome secondary outcome measures obsessive compulsive inventory revised oci beck depression inventory bdi treatment effects assessed tests paired samples results significant reductions bocs oci bdi found large effect sizes cohen results remained stable months follow five prior non responders responded according bocs symptom reduction criterion limitations lack control group small sample size lack repeated outcome measures baseline conclusions sterp may feasible potentially effective treatment prior non responders among ocd patients thus worth investigation randomized controlled trials elsevier ltd rights reserved
recent studies suggest second year life infants attribute false beliefs agents however prior studies largely focused infants ability predict mistaken agent physical actions objects present research investigated whether month old infants could also reason belief based emotional displays experiments infants viewed agent shook two objects one rattled silent infants expected agent express surprise silent object false belief objects rattled merely ignorant objects properties experiment replicated extended findings agent falsely believed two containers held toy bears one infants expected agent express surprise empty full container together results provide first evidence infants second year life understand causal relationship beliefs emotional displays findings thus provide new evidence false belief understanding infancy suggest infants like older children possess robust understanding belief applies broad range belief based responses elsevier rights reserved
background primary headaches include migraines tension type headaches primary headache syndromes migraines tension type headaches associated patient discomfort diseases study aimed investigate association primary headaches risk developing dementia clarify association different types headaches dementia materials methods conducted nationwide matched cohort population based study total patients newly diagnosed primary headaches including migraines tension type headaches january december selected national health insurance research database taiwan along controls matched sex age adjusting confounding factors fine gray competing risk analysis used compare risk developing dementia years follow resuls study subjects developed dementia compared controls fine gray competing risk analysis revealed study subjects likely develop dementia hazard ratio adjusting sex age monthly income urbanization level geographic region residence comorbidities hazard ratio dementia migraines tension type headaches associated nonvascular dementia vascular dementia conclusions patients headaches increased risk dementia studies needed elucidate underlying mechanisms
programmable servo actuated mechanisms enhance flexibility reconfigurability modern manufacturing systems differently fully mechanical design solutions mechanical cams especially case high dynamic motions servomechanism performance depends several interacting factors namely electric motor linkage dynamics controller efficacy requested motion law particular point point ptp trajectories usually designed order comply technological constraints imposed required interaction handled product maximize optimality criterion instance energy efficiency limited actuation torques context present paper proposes novel method designing energy peak power optimal ptp motions standard optimization problem solved means either cubic quintic splines nonetheless differently previous approaches optimization cost functions based virtual prototype system comprises behavioral models power converter controller electric motor coupled mechanical system results compared experimental data obtained physical prototype comparison quantitatively shows better behaved ptp trajectories designed including dynamic contribution subsystem component
fluid dynamics important processes grow large crystals liquid phase paper presents primer fluid mechanics convection followed discussion physics scaling flows processes specific examples fluid flows crystal growth systems presented classified according impact outcomes good bad turbulence crystal growth discussed within limited extent understanding incomplete ugly elsevier ltd rights reserved
background frequent emergency department users account disproportionately high number visits studies case management interventions reduce frequent use shown mixed results studies conducted within universal health coverage system determine whether intervention compared standard emergency care reduces attendance randomized controlled trial two hundred fifty frequent users visits prior months visited public urban lausanne university hospital may july allocated either intervention control group monitored months individualized intervention consisting concrete assistance obtaining income entitlements referral primary specialty medical care access mental health care substance abuse treatment counseling risk behaviors health care utilization addition standard care baseline months used generalized linear model count data negative binomial distribution compare number visits month follow usual care intention treat perspective months visits intervention group versus visits among controls ratio multivariate model effect intervention number visits approached statistical significance presence poor social determinants health significant predictor use multivariate model may reduce use frequent users improved orientation health care system poor social determinants health significantly increase use frequent users
objectives measure early retirement due self reported rheumatic diseases rds estimate respective indirect costs years working life lost ywll methods used individual level data national cross sectional population based epireumapt study september december inhabitants randomly surveyed order capture characterize cases within representative sample portuguese population analysis used participants aged years near official retirement age national database used calculate productivity values gender age region using human capital approach ywll estimated difference participant current age respective retirement age potential years working life lost pywll given difference official actual retirement ages also calculated percentage time inactivity inactivity ratio ywll active age range years old results portuguese population ages years retired self reporting retirement due estimated annual indirect cost following premature retirement attributed sic million sic per capita sic per self reported patient sic per early retiree due females contributed costs sic million sic per capita sic males observed total number accumulated ywll per inhabitants pywll per inhabitants mean ywll pywll inactivity ratios respectively patients higher values disability highest risk early retirement conclusions early retirement attributed self reported amounts approximately national gross domestic product gdp due large ywll public health concern economic impact highlight need prioritize investments health social protection policies targeting patients rheumatic conditions royal society public health published elsevier ltd rights reserved
gender equality progressed great deal recent decades response modernisation industrialisation generally rising level education transformation gender beliefs accompanied progress gender equality beliefs gender roles mainly changed countries north america europe muslim asian countries remained analysis article focuses civic participation investigates relation equalitarian gender beliefs multi level regression models data world values survey wvs collected countries allow depicting relationships findings show membership civic associations covariates equalitarian gender beliefs sign relation depends gender type association
low emissive pigment sio feo feo cro mas prepared chemical deposition method camouflage characteristics coated fabric paint mixed mas binder auxiliary thermal infrared similar optical similar region studied emissivity tester visible light camera thermal infrared imager results show mas pigment low emissivity optical camouflage effectiveness compared sio pigment particularly mas pigment green depositing metal oxide ferrocyanide pure metal surface sio optical reflectance spectrum coated fabric similar natural grass furthermore surface emissivity coated fabric reached region thermography coated fabric mas similar natural grass conclude coated fabric perfectly imitate grass background
wealth observational studies show low testosterone associated insulin resistance increased risk diabetes metabolic syndrome experimental studies identified potential mechanisms low testosterone may lead insulin resistance visceral adipose tissue important intermediate relationship actions testosterone metabolite oestradiol tissues muscle liver bone brain body composition independent effects may also play role however definitive evidence randomised controlled trials rcts clarify whether association low testosterone disordered glucose metabolism causative currently lacking therefore remains possible association due reverse causation simply originates association common health lifestyle factors rcts testosterone therapy men without diabetes consistently show modest metabolically favourable changes body composition despite testosterone effects glucose metabolism inconsistent recent evidence suggests hypothalamic pituitary testicular axis suppression majority obese men metabolic disorders functional may least part reversible weight loss evidence available lifestyle measures emphasis weight reduction treatment comorbidities optimisation diabetic control remain first line treatment men measures successful may sufficient normalise testosterone levels men metabolic disorders typically modest reductions circulating testosterone levels
cognitive dysfunction disabling core feature schizophrenia cognitive impairments linked disturbances inhibitory gamma aminobutyric acid gaba neurons prefrontal cortex cognitive deficits present well onset psychotic symptoms detected early childhood developmental delays reported first year life data suggest pathogenetic process produces dysfunction prefrontal gaba neurons schizophrenia may related altered prenatal development interestingly adult postmortem schizophrenia brain tissue studies provided evidence consistent disease process affects different stages prenatal development specific subpopulations prefrontal gaba neurons prenatal ontogeny birth proliferation migration phenotypic specification distinct subpopulations cortical gaba neurons differentially regulated host transcription factors chemokine receptors molecular markers review article propose strategy investigate alterations expression developmental regulators subpopulations cortical gaba neurons may contribute pathogenesis cortical gaba neuron dysfunction consequently cognitive impairments schizophrenia
qualitative study examined foster parents perceptions initial transition period order better understand family formation process occurs new placement transitioned home snowball sampling method used recruit ten foster parents participate constant comparative analysis interview transcripts guided grounded theory approaches yielded model foster family transition process identified three main tasks establishing trust sense belonging establishing family homeostasis working external stakeholders responsive trauma sensitive care realistic expectations parenting skills access resources facilitated foster family movement transition process foster families shared many tasks family forms adding new member unique aspects foster family context identified foster families often form incomplete knowledge new family member medical trauma history oversight social service system unlike family types permanence primary objective foster family formation study findings implications foster parent training support transition new placement affirm value including foster parents perspectives research
behavior analysis produced robust theoretical analysis contingencies involved cultural evolution yet thus far empirical yield work remains quite limited paper attempt provide specific examples ways advance experimental analysis contingencies involved cultural evolution begin review theoretical analyses developed behavior analysts contextually oriented scientists next submit goal science predicting influencing cultural phenomena must produce experimental analyses impact meta contingencies organizations practices pressing reason threat climate change posed continuing growth human use fossil fuels therefore paper provides analysis contingencies influencing organizational practices affecting continued use fossil fuels contingencies organizations seeking prevent use one concrete step advance science cultural change relevant climate change would create database organizations promoting working prevent fossil fuel consumption consequences seem maintain practices call experimental analysis impact altering consequences practices experimental analyses interventions intended change norms values behavior organizational leaders influence fossil fuel consumption discuss role prosocial behavior values affecting behavior relevant reducing fossil fuel consumption empirical evidence shows prosociality favors green behavior recent advances prevention research identified interventions promote prosociality need experimental analyses advocacy organizations effective getting interventions widely adopted
glutamine plus glutamate glx well acetylaspartate compounds naac acetylaspartate plus acetyl aspartyl glutamate marker neuronal viability quantified proton magnetic resonance spectroscopy mrs used mrs imaging assess glx naac well totalcholine glycerophospho choline plus phospho choline myo inositol total creatine creatine plus phosphocreatine axial supraventricular slab gray matter medial frontal medial parietal white matter bilateral frontal bilateralparietal voxels schizophrenia subjects healthy controls broad age range studied schizophrenia glx increased regardless age however greater age naac increased decreased schizophrenia patients total creatine decreased age finally overall cognitive score correlated positively neurometabolites controls negatively schizophrenia group naac creatine younger speculate results support ongoing process increased glutamate metabolism schizophrenia later illness disease progression suggested increased cortical compaction without neuronal loss elevated naac reduced axonal integrity lower naac furthermore process associated fundamentally altered relationships neurometabolite concentrations cognitive function schizophrenia
recently electric vehicles got significant attention eco friendly efficient internal combustion engine vehicles instead internal combustion engine electric vehicle motor propulsion permanent magnet synchronous motor permanent magnet instead field winding rotor especially higher efficiency power density types motor irreversible demagnetization occurred drivers exposed high risk accident fault operation motor therefore irreversible demagnetization permanent magnet detected reduce risk accident study demagnetization diagnosis method based result locked rotor test proposed based short measurement time proposed diagnosis method aims detect demagnetization fault electric vehicle complete standstill proposed method verified finite element analysis
race achieve global targets longer gear ratios helps reduce fuel consumption significant extent operating point internal combustion engine shifts lower speeds specific torque increased measures lead pronounced rotational irregularity however resulting higher design requirements vibration isolation nevertheless reliably met current technology incorporated today engines targeted next evolution stage problem revolves around next generation engines require even capable systems although technology offered dual mass flywheel conjunction centrifugal pendulum absorber prime candidate summation damper also worth considering way found extend high potential low operating speeds mid range higher speeds schaeffler continues investigate concepts great deal interest key developing responsive summation damper lies ability vary one relevant parameter respect engine speed solution robust affordable deployed large scale yet crystallized however
cloud enterprise resource planning erp buzz information technology domain small medium enterprises smes financial budget invest premise erp solution use cloud based services smes led widespread diffusion technology two big stakeholders cloud erp cloud user cloud vendor paper brings factors influence two stakeholders critical success factors influenced people organization considered study compliance network security concerns control cloud vendor study shows factors impact successful implementation cloud erp online questionnaire designed data respondents belonging smes collected structural equation modeling used data analysis found people related factors compliance impact toward successful implementation cloud based services network security factors show significant impact implementation cloud erp copyright john wiley sons ltd
future low end embedded systems make increased use heterogeneous mpsocs utilize systems efficiently methods tools required support extraction implementation parallelism typically found embedded applications ideally large amounts existing legacy code reused ported new systems existing parallelization infrastructures however mostly support parallelization according requirements hpec systems resource restricted embedded systems different parallelization strategies necessary achieve additional non functional objectives reduction energy consumption hpc focused parallelization also assumes processor memory communication structures different low end embedded systems therefore wastes optimization opportunities essential improving performance resource constrained embedded systems paper describes new approach infrastructure inspired openmp api support extraction implementation pipeline parallelism commonly found complex embedded applications addition advanced techniques extract parallelism legacy applications requiring minimal code modifications presented resulting toolflow combines advanced parallelization mapping communication optimization tools leading efficient approach exploit parallelism typical embedded applications heterogeneous mpsocs running distributed real time operating systems elsevier inc rights reserved
social projection self stereotyping rival explanations self correspondence people tend perceive high degree similarity others present research shows accounts correct knowledge self knowledge others mutually constraining study participants whose self views experimentally manipulated revised judgments immediate ingroup study analogous manipulation ingroup traits altered participants self views study participants ascribed trait readily projected stereotyped relevant ingroup outgroup finally study provides reaction latency evidence social projection self stereotyping judgmental processes leading self correspondence task participants referenced self knowledge reaching ingroup descriptiveness judgments evidence social projection ingroup knowledge judging self evidence self stereotyping implications debate protocentric egocentric accounts person perception discussed
increases woody plant cover savanna grassland environments reported globally years generally perceived threat rangeland productivity biodiversity despite attempts made estimate extent woodland increase national scale principally due technical constraints availability appropriate remote sensing products study aimed measure extent woodlands replaced grasslands south africa grassy biomes use multiseason landsat data conjunction satellite band radar backscatter data estimate extent woodlands grasslands method employed allows unique nationwide measurement transitions grassland woodland classes recent decades estimate year study period woodlands replaced grasslands similar conversely grasslands replaced woodlands similar net increase extent woodland similar annual increase changes varied markedly across country areas receiving mean annual precipitation showed higher rates woodland expansion regions receiving woodland change map presented provides unique opportunity test numerous models woody plant encroachment national regional scale
various designated precipitation hardening cold working employed improve mechanical properties aluminum magnesium silicon alloys aim study study high strength excellent ductility could achieved two main processes competing cold working combined precipitation hardening dislocation annihilation age treatment improves ductility dislocation pinning precipitates increases strength materials paper mechanical properties cold rolled sheets pre aging single double aging conditions compared different sequences precipitation hardening cold working employed achieve high strength excellent ductility results show amount initial cold rolling pre aging may negligible effect strength hardness significant effect ductility alloy
development molecular scale electronics stimulates search new functional materials compounds one promising directions growth within field bioelectronics assumes use electron transfer mediating properties bio related compounds structural functional versatility peptides proteins particularly well suited perform single molecule based elements circuits sensing devices review demonstrated purposely designed systems molecular junctions excellent platforms studies properties peptides proteins nanoscale level using experimental approach based scanning probe microscopy individual molecules directly wired two metallic contacts conductance determined behavior peptides proteins analyzed terms applicability molecular wires switches diodes elements sensing devices wiley periodicals inc
background multiple factors determine children nutritional status including energy nutrient intake recurrent infectious diseases access lack thereof clean water improved sanitation hygiene practices among others vegetables school improving nutrition agricultural diversification vgts project implements integrated school garden programme five countries including burkina faso aim study determine prevalence undernutrition risk factors among schoolchildren burkina faso start project methods february cross sectional survey carried among randomly selected children aged years eight schools plateau central centre ouest regions burkina faso nutritional status determined anthropometric assessment helminth intestinal protozoa infections assessed using kato katz formalin ether concentration method urine filtration technique used identify schistosoma haematobium eggs prevalence anaemia determined measuring haemoglobin levels finger prick blood samples questionnaires administered children determine knowledge nutrition health related attitudes practices kap questionnaires also administered children caregivers identify basic household socio demographic economic characteristics water sanitation hygiene wash conditions determine factors associated schoolchildren nutritional status mixed logistic regression models used differences associations considered statistically significant values results complete datasets available children prevalence undernutrition stunting thinness respectively multivariable analysis revealed undernutrition associated older age years compared years adjusted odds ratio aor confidence interval multiple pathogenic parasitic infections aor moderate severe anaemia children aor conclusions found high prevalence undernutrition among children surveyed two study regions burkina faso observed undernutrition anaemia parasitic infections strongly associated view findings concerted efforts needed address undernutrition associated risk factors among school aged children part vgts project wash health education nutritional interventions implemented goal improve children health
reduction emissions harbours particular importance due proximity human habitation vessels normally run onboard generators typically using diesel fuel provide service loads berthed new upcoming regulations aim decrease emissions shipping coupled increased environmental consciousness ship owners harbour operators shore supply becoming popular feasible option cold ironing provides alternative locally emission free solution berthed ships plug shore electrical network onboard electrical energy demand supplied land electrically number different shore network topologies possible providing different infrastructural options supplying power multiple berths paper examines electrical characteristics one installation impact shoreside electrical network existing port using actual visiting ship power profiles paper examines cold ironing system influences important electrical network characteristics bus voltages power quality well potential impact rest utility distribution system elsevier ltd rights reserved
based success animal models type diabetes clinical trials adoptive regulatory cell treg therapy underway using vivo expanded polyclonal tregs however pre clinical data also demonstrate islet specific tregs potent polyclonal tregs reversing translation approach man require methods generate large populations islet specific tregs date proved major hurdle demonstrate feasibility lentiviral mediated cell receptor tcr gene transfer confer antigen specificity polyclonal human tregs targeting achieved using tcrs isolated human islet specific viral specific cell clones engineered cells demonstrated expression ectopically delivered tcrs resulting endowment cognate antigen specific responses enabled antigen specific suppression increased potency compared polyclonal tregs however cells transduced islet specific tcrs less responsive cognate antigen viral specific tcrs cases required additional methods isolate functional antigen specific tregs study demonstrates potential tcr gene transfer develop islet specific treg therapies effective treatment also highlights additional optimisation may required achieve full potential published elsevier ltd rights reserved
thermal conductivities powdered granular bentonite based needle punched geosynthetic clay liners gcls investigated different gravimetric water contents kpa vertical stresses types gcls exhibited increase thermal conductivity increasing vertical stress water contents effect vertical stresses pronounced specimens hydrated lower gravimetric water contents attributed high initial volumetric air content variability water distribution partially hydrated gcls identified factor may affect thermal conductivity forms bentonites powder granular affected thermal conductivities however effect less apparent higher gravimetric water contents due reduced air content gel formation bentonites finally gcl thermal conductivity calculated measured thermal conductivities various constituents geotextile bentonite components differed measured values attributed nonuniform water distribution across gcl specimen change material properties components gcl disassembled
representation minority ethnic communities acute issue many countries east southeast asia muslim majority indonesia rise jakarta governor basuki tjahaja purnama nicknamed ahok surprising phenomenon given ethnic religious minority status christian chinese descent even surprising initial success politician despite controversial style communication appears contrast prevailing cultural norms argue reason ahok unlikely rise prominence lay ability reshape political narrative shifting focus indonesian ness away ethnic religious identity moral values based transparency integrity ethnicity identity remain powerful forces indonesian politics argue ahok established charismatic relationship followers positioning opposition pressing concerns contemporary indonesia
stream restoration practice typically relies geomorphological design approach integration ecological criteria limited generally qualitative although commonly stated project objective restore biological integrity enhancing habitat water quality restoration achieved mixed results terms ecological successes evident improved methodologies assessment design needed design approach suggested mesohabitat restoration based review integration fundamental processes associated lotic ecological concepts applied geomorphic processes mesohabitat self maintenance multidimensional hydraulics habitat suitability modeling species functional traits correlated fish mesohabitat use multi stage ecohydraulics based mesohabitat classification classification mesohabitat units demonstrated article based fish preferences specifically linked functional trait strategies feeding resting evasion spawning flow refugia recognizing habitat preferences shift season flow stage multi stage classification scheme developed premise provides basic building blocks ecological design criteria stream restoration scheme developed midwest prairie streams conceptual framework mesohabitat classification functional traits analysis applied ecoregions
according culturing full time master degree field control engineering practical experience summary discussion made targeting training goals setting course improving ability engineering practice researching cooperation monitoring system establishing practical assessment evaluation mechanisms building faculty effective way explored training control engineering full time masters
model predictive control mpc technique solar based series resonant inverter conventionally used domestic heating explored photovoltaic energy system pves converts solar energy electrical energy voltages different cells linked common bus cuk converter used interface pves load bus heating inverter heating inverters replacing gas cookers restaurants guest rooms domestic commercial kitchens cooking various foods number control algorithms employed control power heating inverter certain limitations especially predict future response circuit mpc advanced control approach potential estimate future behaviour model predictive manner hence control power resonant inverter connected heating load mpc applied simulation results verify validity power control solar based series resonant inverter using mpc algorithm
although relation tonality musical memory fairly well studied less known regarding contribution tonal schematic expectancies relation three experiments investigated influence tonal expectancies memory single tones tonal melodic context first experiment listener responses indicated superior recognition expected unexpected targets major tonal context moderately expected targets importantly support previous work false memories listener responses also revealed higher false alarm rate expected unexpected targets results indicate roles tonal schematic congruency well distinctiveness memory melodic tones second experiment utilized minor melodies weakened tonal expectancies since minor tonality represented three forms simultaneously finally tonal expectancies abolished entirely third experiment use atonal melodies accordingly expectancy based results observed first experiment disrupted second experiment disappeared third experiment results discussed light schema theory musical expectancy classic memory work availability distinctiveness heuristics
literature reported several factors could impact quality life caregivers patients psychiatric illnesses study aimed determine level quality life among sample caregivers patients psychiatric illness two patient mental health clinics northern jordan examine relationships sociodemographic characteristics stigma caregiver perceptions burden quality life correlational descriptive design utilized three self administered questionnaires used results indicated patients low moderate qol suffered moderate high stigma also family caregivers perceived low moderate qol patients family caregivers stigma perception correlated negatively significantly whoqol bref family caregivers burden correlated negatively significantly domains whoqol bref total qol self reported general health health care providers assure importance focusing toward minimizing stigma promoting physical general health maintain good quality life caregivers patients mental illnesses
pervious pavements offer solution rainwater runoff treatment urban areas combining storm water management water reuse purposes sub bases become rainwater reservoirs furthermore thermal behaviour research systems demonstrated contribution palliating urban heat island effect hottest season delaying freezing coldest season recent investigations related pervious pavements sub bases enabled use structures combined ground source heat pumps gshp addition well known applications aim field study investigate temperature response observations water stored sub bases different pervious pavements specific conditions order evaluate possibility introducing gshp technology base sub base temperatures different types pervious pavements monitored one year results obtained show differences pervious pavements temperature compared air temperature period study demonstrate sub base less affected air temperature base due insulating capacity pervious pavements hand water samples taken different pervious pavement sub bases order assess water quality deterioration due temperatures reached sub base focused investigating presence legionella particular aquatic environment
paper represents design procedure basic two stage cmos operational amplifier using miller compensation technique ltspice simulation tool used present system result low capacitive load different characteristics miller capacitor creates undesirable right half plane rhp zero due non inverting feedforward signal path induced input second stage towards output eliminated using voltage buffer work shows two stage amplifier miller compensation techniques simulated using ltspice simulation tool cmos technology process capacitive load drive amplifier achieves voltage gain approximate exactly double gain bandwidth gbw shows phase margin degrees degrees degrees slew rate dissipating power value supply voltage cmos technology respectively
fast adaptive parallel factor parafac decomposition algorithm proposed class third order tensors one dimension growing linearly time based alternating least squares approach conjunction newton type optimization technique preserving khatri rao product exploiting reduced rank update structure estimated subspace time instant algorithm achieves linear complexity superior convergence performance modified version algorithm also proposed deal non negative constraint addition parallel implementation issues investigated finally performance algorithm numerically studied compared several state art algorithms elsevier inc rights reserved
realistic finite element simulation piezoceramics material parameters must accurately known inverse methods used determination frequently depend influence material parameters complex impedance curve used measured quantity influence increased modification electrodes combination adapted electrical network thereby sensitivity increased material parameters identified single specimen
information sharing integral part human interaction serves build social relationships affects attitudes behaviors individuals large groups present unifying neurocognitive framework mechanisms underlying information sharing scale virality argue expectations regarding self related social consequences sharing form potential self enhancement social approval integrated domain general value signal encodes value sharing piece information value signal translates population level virality two studies participants tested hypotheses using functional neuroimaging neural activity response new york times articles observed theory driven regions interest associated value self social cognitions activity linked objectively logged population level data encompassing internet shares articles studies activity neural regions associated self related social cognition indirectly related population level sharing increased neural activation brain value system neural activity predicted population level outcomes variance explained article characteristics commonly used self report measures sharing intentions parsimonious framework may help advance theory improve predictive models inform new approaches effective intervention broadly data shed light core functions sharing express positive ways strengthen social bonds
always difficult problem demonstrate users perceptual demand form design home service robots paper relationship design elements head form home service robots perceptual evaluation users analyzed quantitatively kansei engineering neural network finally aided design system home service robots head form constructed using language trained network modeling software furthermore considered results applied overall form design home service robots impacts different design constraints also incorporated input layer network thus comprehensive aided design system home service robots could established
paper deals design controller possessing tracking capability realisable reference trajectory rejecting measurement noise consider discrete time varying multi input multi output stable linear systems proportional integral derivative pid controller novel recursive algorithm estimating time varying pid gains proposed development proposed algorithm based minimising stochastic performance index implementation proposed algorithm described boundedness trajectories convergence characteristics presented discretised continuous time model simulation results included illustrate performance capabilities proposed algorithm
background prehospital care providers unique position provide initial unadulterated information scene child abusively injured neglected however receive minimal training respect detection child abuse neglect make reports suspected child protective services aims explore barriers facilitators recognition reporting prehospital care providers design methods twenty eight prehospital care providers participated simulated case infant abusive head trauma prior participating one one semi structured qualitative debriefs researchers independently coded transcripts debriefing collectively refined codes created themes data collection analysis continued past point thematic saturation results providers described key tasks caring patient thought maltreated medically managing patient included assessment patient airway breathing circulation management chief complaint followed evaluation evaluating scene family interactions signs suggestive included gathering information presence elicit substances observing child behaves presence caregivers creating safety plan included calling police support avoiding confrontation caregivers sharing suspicion hospital providers child protective services reported barriers recognizing included discomfort pediatric patients uncertainty related accepting parental story alternative diagnosis difficulty distinguishing accidental intentional injuries focus chief complaint limited opportunity evaluation barriers reporting included fear wrong fear caregiver reactions working fast paced setting contrast facilitators reporting included understanding mandated reporter role sharing thought processes peers supervisor support conclusions prehospital care providers unique vantage point detecting limited resources knowledge related topic focused education recognition signs physical abuse increased training scene safety real time decision support increased follow related cases may improve detection
study aimed screen lymphatic metastasis related micrornas mirnas lung adenocarcinoma explore underlying mechanisms using bioinformatics mirna expression primary lung adenocarcinoma matched adjacent non tumorigenic lymph node metastasis tissues patients profiled via microarray screened metastasis related mirnas validated using quantitative real time pcr second cohort lung adenocarcinoma patients lymphatic metastasis significance determined using paired test target genes metastasis related mirnas predicted using targetscan transcription factors tfs predicted based transfac encode databases furthermore related long non coding rnas incrnas screened starbase mirna mrna incrna mirna mrna networks constructed determine key interactions associated lung adenocarcinoma metastasis according mirna microarray results mirnas differentially expressed metastatic tissues compared primary tumor adjacent non tumorigenic tissues among increased levels mir mir mir validated second cohort based mirna mrna network vascular endothelial growth factor transcription factors tfs including smad recognized critical targets three mirnas interactions involving snhg mir smad mir mir highlighted according incrna mirna mrna network mir mir mir lymphatic metastasis related mirnas lung adenocarcinoma bioinformatics analyses demonstrated snhg might inhibit interaction mir smad might weaken mir mir interactions metastasis
first decades nineteenth century characterized publication numerous french engineering architecture treatises treatises important formalization solution structural mechanics problems particular tests resistance bending difficult path bounded galileo theories mathematical theoretical apparatus experimental tests well proper solution problem marked also intuitions errors false ideas huge experimental research order find rules related strength materials design based attention focused works pierre simon girard jean baptiste rondelet jean henri hassenfratz emiland marie gauthey joseph mathieu sganzin claude louis navier preceded brief introduction works antoine parent george louis leclerc comte buffon constant reference made study reference made wood whose mechanical characteristics let observation mechanical behavior bending possible
purpose ambient light stimulus visual function regulator photoreceptor physiology however known light regulate aspect photoreceptor development purpose study investigate whether ambient light required development mouse rod photoreceptors methods newborn mouse pups cbl reared either cyclic light constant dark pups collected postnatal day performed retinal morphometric cell death analysis rhodopsin expression assessed using immunofluorescence western blot quantitative pcr analysis electroretinograms performed radioimmunoassay elisa used follow changes thyroid hormone levels serum vitreous results pups outer nuclear layer significantly thinner higher numbers apoptotic cells compared pups rhodopsin expression lower pups electroretinogram waves reduced amplitude pups animals lower levels circulating thyroid hormones light mediated changes thyroid hormones occur early detected lower levels total triiodothyronine vitreous animals drug induced developmental hypothyroidism resulted lower rhodopsin expression conclusions data demonstrate light exposure postnatal development required rod photoreceptor development effect could mediated thyroid hormone signaling
increasing demand water energy sources accompanied continued increases prices sources observed worldwide resulted need seek alternative sources response statement cost effective analysis carried enable use selected systems reduce demands potable water natural gas used heating single family homes study includes drain water heat recovery system gray water harvesting system rainwater harvesting system life cycle cost methodology applied tool analysis depending number users rate piped water consumption determined life cycle cost indicator ranged sic sic study shown highest life cycle cost characteristic graywater recycling variant circumstances water consumption homes purposes showering toilet flushing exceeded per day cost effective option combines systems analyzed preferred cases use rainwater harvesting system sensitivity analysis carried also shown costs changes associated building water supply sewerage facilities greatest impact life cycle costs solution analysis shown systems consideration could serve alternatives traditional installations use resulted reductions consumption fossil fuels natural water resources thus contributing environmental improvements elsevier ltd rights reserved
context soluble ligand scdl predict cardiovascular events cve mortality haemodialysis patients short medium term follow studies objective evaluate relationship scdl survival cve mortality patients long term follow methods registered patients baseline characteristics mortality cve months results scdl correlated positively reactive protein higher survivors impact survival predictive cve mortality conclusion levels scdl influence survival cve mortality patients long term follow
introduction determine whether addition aspirin statin regimen beneficial reducing cardiovascular mortality analyzed data uncomplicated hypertensive patients included korea national health insurance sample cohort method among eligible participants aged years older participants selected divided four groups treatment group aspirin alone group statins alone group combined treatment group mean follow duration months primary outcome study cause cardiovascular mortality results treatment aspirin alone hazard ratio confidence interval treatment statins alone combined treatment independently associated reductions cause mortality treatment aspirin alone treatment statins alone combined treatment also independently associated reductions cardiovascular mortality addition aspirin statins associated additive benefit reducing total mortality cardiovascular mortality conclusion primary prevention aspirin statins beneficial reducing cause cardiovascular mortality uncomplicated hypertensive participants nevertheless aspirin administration associated increased risk major bleeding care must taken assess risk benefit using aspirin primary prevention
expansion big data evolution internet things iot technologies played important role feasibility smart city initiatives big data offer potential cities obtain valuable insights large amount data collected various sources iot allows integration sensors radio frequency identification bluetooth real world environment using highly networked services combination iot big data unexplored research area brought new interesting challenges achieving goal future smart cities new challenges focus primarily problems related business technology enable cities actualize vision principles requirements applications smart cities realizing main smart environment characteristics paper describe state art communication technologies smart based applications used within context smart cities visions big data analytics support smart cities discussed focusing big data fundamentally change urban populations different levels moreover future business model big data smart cities proposed business technological research challenges identified study serve benchmark researchers industries future progress development smart cities context big data elsevier ltd rights reserved
expectations resource efficiency climate change adaptation construction industry increasing need contractors implement sustainable practices action burden contractors additional costs lower economic performance research studies sustainability relates firm competitiveness paper represents empirical study relationship sustainability performance business competitiveness international construction contractors inverse shape relationship contractors sustainability performance international revenue shape relationship contractors sustainability performance international revenue growth discovered findings help international contractors better understanding relationship sustainability performance business competitiveness evaluate current position relationship optimize resource allocation sustainable development integrate sustainability strategic planning therefore contractors high sustainability performance expect higher international revenue growth sustainability performance likely become opportunity competitive advantage international construction market elsevier ltd rights reserved
cells participate regulating immune response inflammation mirna type small noncoding rna regulate gene expression posttranscriptional level study investigated mir expression role cells arthritis cells isolated synovia arthritis patients healthy control using immunomagnetic beads test mir expression mir target gene predicted bioinformatics confirmed luciferase reporter gene assay pdpn level cells detected western blot mir inhibitor transfected change mir expression jurkat cells cell cycle evaluated flow cytometry pdpn inflammatory cytokines expressions tested western blot mir expression downregulated cells arthritis patients compared healthy control pdpn jianhgleconfirmed target gene mir bioinformatics luciferase reporter gene assay mir downregulation cells obviously shortened cell cycle enhanced cell proliferation promoted pdpn expression facilitated inflammatory cytokines release including tnf alpha mmp mir expression reduced cells synovia arthritis patients thus enhance cells proliferation elevate pdpn expression promote inflammatory cytokines release
current european policies define targets future direct emissions new car sales foster fast transition electric drivetrain technologies however targets consider emissions produced electricity generation material production therefore fail incentivise car manufacturers consider benefits vehicle weight reduction paper examine potential benefits limiting average weight altering material composition new cars terms global greenhouse gas emissions produced use phase electricity generation material production anticipate emissions savings future car fleet great britain various alternative futures using dynamic material flow analysis ferrous metals aluminium considering evolving demand car use results suggest fostering vehicle weight reduction could produce greater cumulative emissions savings obtained incentivising fast transition electric drivetrains unless extreme decarbonization electricity grid savings promoted weight reduction immediate depend pace decarbonization electricity grid weight reduction may produce greatest savings mild steel car body replaced high strength steel article part themed issue material demand reduction
wide variation reported impact caring caregiver wellbeing often negative appraisal caregiving researchers beginning question robustness evidence base negative appraisals based present study aimed draw data population representative sample describe health quality life impact caring informal caregivers people intellectual disability informal carers people intellectual disability identified among carers english survey carers households generalised estimating equations explored association socio demographic caring profile quality life physical health status impact psychological health personal life compared caregivers providing care person intellectual disability associated reduced quality life increased risk reporting poorer health status even though poorer health likely attributed caregiving higher risk negative impact personal life seen comparison wider group caregivers comparison similar sized caregiver groups mental health dementia carers people intellectual disability likely struggling financially high caring load factors systematically related lower well uniformly negative appraisal caring people intellectual disability supported english population representative data poverty long caregiving hours may make caregivers susceptible negative wellbeing support caregivers people intellectual disability focus alleviating two factors
background laparoscopic adjustable gastric banding lagb safe proven surgical option morbid obesity however need revisional surgery increasingly reported study reports outcomes incidence large cohort patients requiring revisional lagb surgery various indications methods retrospective review prospectively collected data primary lagb placed single surgeon single institution performed analysing data patients cohort requiring revisional lagb surgery results total revisions performed patients total patients single revision patients two revisions revisions amounting band repositions band removal band removal conversion another bariatric procedure mostly roux gastric bypass total band band revision patients lost follow patients undergoing band band revision slipped band patient intolerance mechanical band failure mean excess weight loss ewl years respectively port tubing revisions included mean follow band band revision patients months standard deviation months patients required one band revision procedures increased conclusion continued ewl achieved repositioning replacement lagb however significant increasing rate operation time exists
ability design metal forming processes requires knowledge continuum mechanics materials engineering papers presents results research complete analysis forging process microalloyed steel forging process assessment performed based thermomechanical calculations using microstructural modeling hardness tests employed verification computed results method predicting relation quality final product history metal forming well microstructural development using fem simulation also presented results fem simulation forging process material compared experimental data show feasibility proposed method finally stated using properly built software possible eliminate brittle cracking forged products especially low temperatures
recent studies investigated potential type diabetes mellitus related autoantigens heat shock protein induce immunological tolerance suppress immune response functional residue peptide derived heat shock protein shown anti type diabetes mellitus potential experimental animals clinical studies also carries potential atherogenic effect study modified retain anti type diabetes mellitus effect minimize atherogenic potential replacing epitope another diabetes associated autoantigen insulinoma antigen create fusion peptide streptozotocin induced diabetic cbl mice peptide displayed similar anti diabetic effects control peptide also peptide show atherogenic activity rabbit model findings indicate potential promising vaccine type diabetes mellitus
smart home service market growing sensor network technologies developed makes life pattern simpler safer richer user identification technologies investigated provide personalized service floor sensing reasonable way arises little privacy issues however installation cost problem installed whole floor paper propose novel smart home sensor system foot mat shaped user identification sensor
methodology design thermal distortion compensation system presented assist manufacturing processes reach higher levels accuracy working large machines common shop floor environments parametric state space representation selected model architecture providing multiple inputs outputs capability compact formulation takes account previous thermal states machine inputs model spindle speed temperatures main motor gearbox room air outputs estimations thermal drift machine tool centre point along three axes different positions within working volume model parameters numerically identified initial experimental tests performed large gantry type milling machine measuring mentioned variables also thermal distortion values using reference artifact along non contact proximity sensors proposed model finally verified new validation measurement machine obtained results revealed error reduction vertical axis comprised total thermal effects longitudinal axis comprised total thermal effects also concluded model benefits using valuable information machine state previous spindle speed register instead using temperature values proposed methodology benefits providing feasible implementation real shop floor conditions without necessity including additional temperature sensors probing systems machine elsevier ltd rights reserved
pixel level image fusion applied variety applications including multi modal medical imaging remote sensing industrial inspection video surveillance night vision etc various algorithms proposed numerous applications requires comprehensive method assessment discern methods provide decision support currently validation assessment newly proposed algorithms done either subjectively objectively subjective assessment costly affected number factors difficult control hand objective assessment carried fusion performance metric defined evaluate effectiveness efficiency fusion operation number fusion metrics proposed fusion processes taking different perspectives image fusion research presents comparison proposed existing fusion algorithms selected fusion metric multiple image data sets proposed algorithm advantage justified relative difference best better metric values however statistical significance difference unknown leading misperception quantitative differences methods paper proposes use non parametric statistical analysis comparisons fusion algorithms along image fusion toolbox employing significance testing imtest strategies use different tests varied scenarios presented recommended experiments recently published algorithms demonstrate necessity adopt statistical comparison establish baseline image fusion research elsevier rights reserved
elaborating misleading information concerning emotional events lead people form false memories present experiment compared participants susceptibility false memories elaborated information associated positive versus negative emotion pregoal versus postgoal emotion pregoal emotion reflects appraisals goal attainment failure anticipated yet occurred hope fear postgoal emotion reflects appraisals goal attainment failure already occurred happiness devastation participants watched slideshow depicting interaction couple asked empathise protagonist feelings hope positive pregoal happiness positive postgoal fear negative pregoal devastation negative postgoal control conditions emotion mentioned participants asked reflect details interaction occurred true occurred false relevant irrelevant protagonist goal irrespective emotional valence participants pregoal conditions susceptible false memories concerning goal irrelevant details participants conditions findings support view pregoal emotions narrow attention information relevant goal pursuit increasing susceptibility false memories irrelevant information
study uses large longitudinal multisector administrative datasets families investigated child welfare services maltreatment explore children likely later enter psychiatric residential treatment facilities question grounded pressing interest understand costly highly restrictive mental health treatment settings use statewide data one southeastern state linked multiple systems child welfare services income maintenance medicaid use cox regression analyses develop models predicting psychiatric residential treatment facilities entry among children years whose families investigated maltreatment findings show children families enter foster care heightened risk psychiatric residential treatment facilities entry hazard ratio controlling factors study findings build body research underscoring importance overlap child welfare mental health systems child well
targeting receptor results neuroprotection sod mutant mouse model amyotrophic lateral sclerosis als neuroprotective effects receptors facilitated upregulation spinal cord mutant mice investigated whether similar receptor upregulation well parallel changes endocannabinoid elements evident spinal cord dogs degenerative myelopathy caused mutations superoxide dismutase gene sod used well characterized post mortem spinal cords unaffected affected dogs tissues used first confirm loss motor neurons using nissl staining accompanied glial reactivity elevated gfap iba immunoreactivity next investigated possible differences expression endocannabinoid genes measured qpcr affected control dogs found changes expression receptor confirmed receptor immunostaining nape pld dagl faah magl enzymes contrast receptor levels significantly elevated affected dogs determined qpcr western blotting confirmed grey matter using receptor immunostaining using double labelling immunofluorescence receptor immunolabelling colocalized gfap iba indicating upregulation receptors astrocytes affected dogs results demonstrate marked upregulation receptors spinal cord canine concentrated activated astrocytes receptors could used potential target enhance neuroprotective effects exerted glial cells
presented research aimed creating testing control system spooler winding miniature induction coils discussed analysis realized order verify possibility synchronizing speed spindle drive stepping motor speed wire feed unit miniature linear actuator based micromotor method sensorless measurement rotor displacement micromotor applied control position actuator method based analysis current signal pulsation corresponding shaft rotation atmega microcontroller communicating used implement various control algorithms using prototype controller performed tests drive system proving synchronization drives different type means proposed method analyzing current signal micromotor possible authors published elsevier ltd
green city innovation uses industrial entrepreneurial ecosystems reduce environmental ecological risks achieve sustainable urban development without degrading urban environments city entrepreneurship ecosystems include start ups supporting networks coordinating entities contribute economies scale however systems may make city green environment worse contributing air water pollution even though widely held perception adverse relationship urban economic performance urban environmental conditions green city development involving clean industries way attract employees without affecting urban environments negatively however dearth empirical studies examine green related innovative entrepreneurial system could become growth engine cities paper examines whether greener city contribute economic prosperity city two stage econometrics approach method applied using data paper contributes field distinguishing concerns urban environments green cities concerns economic performances related innovative entrepreneurial ecosystems
exposure war associated poor psychosocial outcomes yet effects different types war events various psychosocial outcomes conduct problems remain unknown study aims assess whether various war events differ predicting conduct problems using data going longitudinal research project ways study current article examined relationship specific war events conduct problems war affected youth northern uganda baseline age range regression analyses conducted relate type war experience conduct problems war categories witnessing violence deaths threat loved ones sexual abuse associated reporting conduct problems multivariable models yielded independent effects witnessing violence beta sexual abuse beta conduct problems duration captivity independently negatively predicted conduct problems beta types war events vary predicting conduct problems considered designing interventions alleviate negative consequences exposure war moreover longer duration captivity appear protect war affected youth conduct problems
finding leakage valves important troubleshoot performance internal combustion engines leakage lead reduction engine power increase emissions main objective present study investigate relationship valve leakage acoustic emission generated steady flow cylinder head internal combustion engine test rig cylinder head spark ignited engine test rig simulates valve leakage due valve clearance valve clearance fault artificially simulated small lift valve acoustic emission method used measure acoustic emission signals generated valve flow characteristics acoustic emission signals time frequency domains presented explained effects air pressure level valve lift valve type acoustic emission signals investigated shown acoustic emission energy valve leakage parameters linear correlation results demonstrate potential acoustic emission source identification practical situation detecting valve leakage using investigated relationship
paper presents personalized satellite radio novel satellite based radio concept capable providing radio services vehicular terminals paper describes technical solution proposed overcomes classical streaming approach used traditional radio main concept behind individual audio multimedia files broadcast mobile users instead transmitting number continuous streams received files stored large cache located receiver mobile terminal sequentially played generate service similar traditional radio entertainment programmes resulting file based radio approach makes particular use higher layer coding transport layer smart techniques build audible programme interruptions full audio quality based oil available files paper also presents results extensive trials conducted system prototype developed framework european space agency funded project copyright john wiley sons ltd
mental illness prevalent extraordinarily complex phenomenon psychologists developed distinct approaches toward understanding treatingmental illness rooted divergent epistemology introduction special issue clinical psychological science practice provides brief overview scientist practitioner gap explores one step many toward bridging divide seven compelling case illustrations featured special issue apply empirical findings case formulation treatment selection assessment across complex varied clinical presentations issue thereby demonstrates feasibility integrating research clinical expertise mental healthcare wiley periodicals inc
backgroundthe role local therapy form radiation therapy radical prostatectomy association outcomes well established patients metastatic prostate cancer methodsusing national cancer database ncdb evaluated patterns care outcomes among patients diagnosed metastatic prostate cancer treated local therapy intensity modulated radiation therapy imrt conformal radiation therapy crt association local therapy variates outcomes assessed multivariable cox proportional hazards model propensity score matching performed balance confounding factors survival estimated using kaplan meier method resultsamong patients ncdb prostate cancer patients met inclusion criteria local therapy used patients patients received imrt crt respectively use local therapy associated younger age lower morbidity score lower stage gleason score node negative status private medicare insurance higher income quartile treatment comprehensive academic research programs five year overall survival patients receiving local therapy versus receiving local therapy multivariate analysis imrt independently associated superior overall survival matching use local therapy imrt remained significantly associated overall survival conclusionsthe use imrt treat primary disease associated improvements overall survival patients metastatic prostate cancer identified patient specific variations use local therapy may tested subsequent prospective clinical trials improve patient outcomes setting prostate wiley periodicals inc
development green building received attention various levels government around globe including local authorities two main categories incentives provided local authorities means encouraging development green building include financial structural incentives found financial incentives particular property tax assessment incentives widely adopted several commonwealth countries around globe including spain romania italy bulgaria united states canada malaysia india practice providing property tax assessment incentives within green building field empirically documented several researchers order encourage growth numbers green building instances local level however comprehensive academic study conducted review effect incentive development green building therefore purpose study review discuss available models bases adopted order develop incentive three types property tax assessment incentive models identified available encouraging development green building include reductions exemptions rebates incentives developed based four identified bases specifically include increased amounts property tax assessments completed green buildings costs green components rate imposed property tax assessments level green certification findings identified property tax assessment incentive models regarding green buildings developed basis value green components specifically increased amount property tax assessments green buildings costs green components elsevier ltd rights reserved
tutorial paper describes various efficient implementations published new unpublished forward backward modified discrete cosine transform mdct mpeg layer iii audio coding standard developed time period including efficient implementation polyphase filter banks completeness efficient mdct implementations discussed context fast complete analysis synthesis mdct filter banks encoder decoder general efficient forward backward mdct block transforms implementation presented complete formulas sparse matrix factorizations algorithm corresponding signal flow graph short audio block total arithmetic complexity well useful comments related improving arithmetic complexity possible structural simplification algorithm finally efficient forward backward mdct implementations compared terms arithmetic complexity structural simplicity important note almost presented algorithms also used length data blocks others mpeg audio coding standards proprietary audio compression algorithms elsevier rights reserved
high dynamic range hdr content dynamic range image important characteristic algorithm design validation analysis aesthetic attributes content selection traditionally computed ratio maximum minimum pixel luminance purely objective measure however human visual system perception dynamic range complex largely neglected literature paper new methodology measuring perceived dynamic range pdr chromatic achromatic hdr images proposed pdr benefit hdr number ways evaluating inverse tone mapping operators hdr compression methods aesthetically parameter content selection perceptual studies subjective study conducted data set chromatic achromatic hdr images results showed strong agreement across participants allocated scores addition high correlation ratings chromatic achromatic stimuli found based results pilot study five objective measures pixel based dynamic range image key area bright regions contrast colorfulness selected candidates pdr predictor model two found significant contributors model analyses show model performs better individual metrics achromatic chromatic stimuli
breast cancer epidemic recognised characteristic early twenty first century multifactorial disease spectrum modifiable preventable factors significantly increasing risks described article highlights series underestimated symptoms consequent risk assessment patient stratification phenomena deficient thermoregulation altered sensitivity different stimuli pain thirst smell light stress provocation dehydration altered circadian sleep patterns tendency towards headache migraine attacks dizziness well local systemic hypoxic effects discussed patients providing functional links proposing new approaches overall management
like asthma atopic dermatitis allergic rhinitis allergic disease three type allergic disease allergic rhinitis includes pollinosis intractable reduces quality life qol becomes severe guideline needed understand allergic rhinitis use knowledge develop treatment plan japan first guideline prepared symposium held japanese society allergology current edition published widely used today incorporate evidence based medicine ebm introduced abroad recent collection evidence literature supplemented practical guideline management allergic rhinitis japan revised guideline includes assessment diagnosis treatment prescriptions children pregnant women broad clinical applications evidence based step step strategy treatment also described addition qol concept cost benefit analyses also addressed along allergic rhinitis impact asthma aria guideline widely used various clinical purposes measures patients sinusitis childhood allergic rhinitis oral allergy syndrome anaphylaxis pregnant women section regarding allergic rhinitis japan added end guideline copyright japanese society allergology production hosting elsevier
backgroundmothers intellectual disability face socioeconomic disadvantage social isolation associated poorer child outcomes social services feature prominently lives mothers intellectual disability especially without informal support however role formal support lives children explored methodsseven children aged years took part semi structured interviews explore social experiences stories interactions home school peers analysed illuminate influences including social support lives resultsformal support provide enduring relationship children socially restricted homes focuses child abilities interests needs distinct mother child focused support paid worker volunteer conclusionsfamily support services need apply child focus improve well children vulnerable families
computing deterministic performance guarantees defining issue systems hard real time constraints like reactive embedded systems paper use burst rate constrained arrivals rate latency servers deduce tight worst case delay bounds tandem networks arbitrary multiplexing present constructive method computing exact worst case delay prove linear function burstiness latencies bounds hence symbolic parameters algorithm runs quadratic time number servers also present application algorithm case stochastic arrivals server capacities generalization exponentially bounded burstiness ebb model deduce polynomial time algorithm stochastic delay bounds strictly improve state art separated flow analysis spa type bounds elsevier rights reserved
essure permanent birth control system conceptus inc san carlos currently food drug administration approved hysteroscopic sterilization method widely accepted safe effective procedure present rare case tubal perforation coil fragmentation distal migration small large bowel mesentery days insertion essure device describe successful management complication using laparoscopy intraoperative fluoroscopy providers using essure must aware possibility fragmentation essure coils intraoperative imaging ideally fluoroscopy strongly considered management essure migration ensure localization full retrieval essure material aagl rights reserved
objectives conventional material decomposition techniques dual energy computed tomography assume mass volume conservation number voxel fully assigned predefined materials present image domain contrast material extraction process cmep method preferentially extracts contrast producing materials leaving remaining image intact materials methods image processing freeware fiji used perform consecutive arithmetic operations dual energy ratio map generate masks applied original images generate material specific images first low energy image divided high energy image generate ratio map ratio map split material specific masks ratio intervals known correspond particular materials iodine calcium assigned multiplier whereas ratio values intervals assigned linear gradients masks multiplied original image produce material specific images method tested quantitatively dual source rapid kvp switching rsct phantoms using pure mixed formulations tungsten calcium iodine errors evaluated comparing known material concentrations derived cmep material specific images qualitative evaluation performed vivo rsct rabbit model using identical cmep parameters phantom orally administered tungsten vascularly administered iodine skeletal calcium used contrast materials results material combinations tungsten iodine calcium mixtures tungsten calcium iodine calcium showed distinct dual energy ratios largely independent material concentration dual source rsct cmep successful phantoms vivo pure contrast materials phantom maximum error known cmep derived material concentrations iodine calcium tungsten respectively mixtures iodine calcium showed highest discrepancies reflected sensitivity iodine image type chosen extraction final material specific image rabbit model able clearly show extracted material phases vascular iodine oral tungsten skeletal calcium skeletal calcium misassigned extracted iodine image however impede depiction vasculature conclusions cmep straightforward image domain approach extract material signal dual energy particular value separation experimental high contrast elements conventional iodine contrast calcium even exact attenuation coefficient profiles desired contrast materials may unknown cmep readily implemented image domain within freeware adapted use images multiple vendors
increasing variable generation penetration consequent increase short term variability makes energy storage technologies look attractive especially ancillary market providing frequency regulation services paper presents slow dynamics model compressed air energy storage battery storage technologies used automatic generation control studies assess system frequency response quantify benefits storage technologies providing regulation service paper also represents slow dynamics model power system integrated storage technologies complete state space form storage technologies integrated ieee bus system single area comparative study various solution strategies including transmission enhancement combustion turbine performed terms generation cycling frequency response performance metrics
performance review discussions real manager subordinate pairs examined two studies investigate effects trait emotional intelligence dyad member felt expressed emotions altogether managers subordinates two studies using measured self reported trait facial electromyography frontal electroencephalography eeg asymmetry collected continuously manager high trait related increased positive valence emotional facial expressions dyad discussions managers also eeg frontal asymmetry indicating approach motivation subordinates addition actor partner effects actor partner interactions interactions role actor partner effect trait observed actor partner trait related positive self reported emotional valence results imply trait role organizational social interaction
present efficient cloud computing implementation parallel small baseline subset sbas algorithm advanced differential interferometric synthetic aperture radar dinsar technique generation earth surface displacement time series distributed computing infrastructures rationale approach consists properly distributing large data volumes processing tasks involved sbas chain among available virtual physical computing nodes infrastructure one elements concurrentlywork data physically stored local volume hocmanagement data flow appropriate scheduling parallel jobs also implemented properly handle high complexity sbas workflow proposed solution allows minimizing overall data transfer network load thus improving sbas efficiency scalability within exploited ccenvironments presented sbas implementation extensively validated two experimental analyses carried exploiting amazon web services aws elastic cloud compute resources former analysis involves processing large sar images cosmo skymed dataset performed exploiting computing nodes aimed demonstrating sbas scalable performances latter allows show sbas capability generate dinsar results regional scale southern california short time simultaneously processing envisat frames correspond total sar images exploiting parallel aws computing nodes presented results confirm effectiveness proposed sbasccsolution whichmay contribute extend frontiers dinsar investigation large scale
case horizontally curved highway bridges girders subjected combined action vertical bending torsion due offset although steel concrete composite sections proportioned avoid abrupt brittle failure ultimate strengths composite box girders subjected bending torsion may limited diagonal tensile stress deck concrete induced venant torsion concurrent compressive stresses concrete deck improve shear resisting capacity concrete thereby resulting increased torsional resistance composite box girder positive bending three dimensional finite element analyses classical strength materials investigations conducted study determine ultimate strengths composite box girders bending torsion interaction advanced material model including concrete tension mechanism incorporated incremental nonlinear analyses ultimate strengths numerical data compared theoretically derived values proposed interaction equation simple yet provides rational lower bound determination ultimate strengths concrete steel composite box girders
events consist diverse elements processed specialized neocortical networks temporal lobe memory systems binding elements form coherent event memories provide novel theoretical analysis unexplored consequence independence memory systems elements bindings raises paradoxical prediction schema driven false memories act solely binding event elements despite superior retrieval individual elements schema relevant elements bound together unexpected conjunctions unexpected conjunction increase attention encoding elements bindings bindings receive competition evoked schema expected bindings test model examining memory object location bindings recognition study recall studies tasks studying schema relevant objects unexpected locations pan stool kitchen scene participants viewed objects expected locations pan stove test likely falsely remember object location pairing correct compared participants viewed different unexpected object location pairing pan floor recall participants likely correctly remember individual schema relevant objects originally viewed unexpected opposed expected locations likely misplace items original room scene expected places relative control schema irrelevant objects theoretical analysis novel paradigm provide tool investigating memory distortions acting binding processes
article provides overview witch hunt narrative focusing challenges gathering information young children involved sexual abuse allegations day care article summarizes research methodology witch hunt narrative involves series case studies article articulates cheit hypothesis witch hunt narrative originated two key publications series articles two journalists tom charlier shirley dowling book satan silence ritual abuse making modern day witch hunt debbie nathan michael snedeker notes disputes evidence two publications cheit deals depth three hotly contested day care center cases mcmartin pre school case manhattan beach california wee care day nursery case maplewood new jersey country walk babysitting service case dade county florida article summarizes cheit research conclusions related three cases also notes forensic interview practices used cases would supported today article concludes noting despite impressive progress forensic interviewing children sexual abuse alleged methods gathering information young children remain inadequate moreover easy answers reasons rise fall allegations sexual abuse day care allegations ritual abuse
lack efficient agent disadvantage low activity kojic acid high cytotoxicity mutagenicity hydroquinone poor skin penetration arbutin low stability formulation glabridin led continue research new antipigmentation skinlightening agents therefore research natural products modulate metabolism pigmentation great interest otherwise malignant melanoma one aggressive forms skin cancer high metastatic potential currently effective chemotherapy invasive melanoma therefore necessary develop new drugs potent activity weak side effects melanoma vitro anticancer effect hawthorn analyzed melanoma cells using dimethylthiazol diphenyltetrazolium bromide assay effect isolated compounds hawthorn melanogenesis melanoma cells investigated measuring amounts melanin tyrosinase spectrophotometrically balb mice models inoculated mouse tumor cells used evaluate vivo antitumoral potential hawthorn assessing effect growth transplanted tumors antioxidant potential tested samples evaluated primary human keratinocyte cells using cellular antioxidant activity assay hawthorn tested samples inhibited effectively growth melanoma cells vitro furthermore appears tested samples hawthorn reduced melanogenesis inhibiting tyrosinase activity cells dosedependent manner vivo studies showed hawthorn total oligomer flavonoids extract treatment dose body weight days implanted tumor mice resulted significant inhibition tumor growth volume weight addition tested samples showed significant cellular antioxidant capacity reactive oxygen species primary human keratinocyte cells results indicate hawthorn could considered promising agent treatment melanoma shows antitumor activity vitro vivo moreover hawthorn constituents shown highly effective inhibiting tyrosinase mediated melanogenesis vitro melanoma cells preventing oxidation cells without affecting viability normal human keratinocyte cells hawthorn might also used new candidate natural skin depigmenting agents skin care products wolters kluwer health inc rights reserved
sclerostin product sostgene secreted inhibitor wnt signaling produced osteocytes regulate bone formation often considered osteocyte specific protein sost expression reported numerous cell types including hypertrophic chondrocytes cementocytes interest sost sclerostin expression altered certain pathogenic conditions including osteoarthritis rheumatic joint disease unclear whether sclerostin plays protective role whether sclerostin may mediate disease pathogenesis therefore anti sclerostin antibodies developed treatment osteoporosis important understand functions sclerostin beyond regulation bone formation elsevier inc rights reserved
smart grid control systems need protected internal attacks within perimeter smart grid intelligent electronic devices ieds resource constrained devices ability provide security analysis protection commonly used industrial control system protocols offer little security guarantee guarantee security inside system analysis inspection internal network traffic device status need placed close ieds provide timely information power grid operators designed unique extensible efficient operation level traffic analyzer framework timing evaluation analyzer overhead confirms efficiency smart grid operational traffic
present study investigated much debated happiness gap conservatives liberals approaching issue multilevel person context perspective specifically investigated whether relationship depends country level threat used individual level data right wing attitudes psychological well large representative samples collected worldwide total objective indicators country level threat contextual variable results suggest especially countries characterized high levels threat individuals right wing attitudes experienced greater well individuals left wing attitudes countries low level threat relationship considerably weaker even absent findings corroborate view right wing attitudes may serve self protective function helping individuals manage cope threat
paper influence encapsulating carbonyl iron particles various silica coatings properties magnetorheological elastomers mres investigated soft styrene ethylene butylene styrene thermoplastic elastomer used composite polymer matrix spherical carbonyl iron powder cip acted ferromagnetic filler order improve metal polymer interaction carbonyl iron particles coated two types single six types double silica layers first layer created tmos teos hydrolysis whereas second one composed organosilanes mechanical properties mres containing vol cip analysed dynamic loading conditions investigate magnetorheological effect composites magnetic field generated array permanent magnets applied testing results revealed magnetomechanical response mres differs substantially depending kind particle coating
polycarbonate engineering thermoplastic excellent insulation mechanical properties however low thermal conductivity restricted application electronic devices hexagonal boron nitride microparticle promising material high thermal conductivity functionalized cationic polyacrylamide cpam introduced matrix improve thermal conductivity sem xrd analysis showed modified cbn particles oriented formed thermal conductive pathways within matrix formation large area oriented cbn significantly improved thermal conductivity thermal stability composites cbn loading thermal conductivity temperature weight loss degrees obtained times degrees higher pure respectively furthermore outstanding electrical insulation property matrix retained composites results revealed cbn composite promising material thermal management electrical enclosure wiley periodicals inc
paper presents new environment characterizing foundry cmos device models analog basic blocks environment also used design analog basic building blocks designs analog circuits dividing set basic building blocks connected together block optimized separately considering blocks loading boundary conditions run different technologies using foundry models simulation measurements without approximations hand calculations simplified equations efficiency complete flow evaluated designing single ended two stage operational amplifier technologies
paper presents hamster healthy mobility security based data communication architecture hamster designed unmanned vehicles addresses mainly three types communications machine machine machine infrastructure internal machine communications divided three main versions flying hamster aerial systems running hamster terrestrial systems swimming hamster aquatic systems every version architecture also equipped sphere nimble sphere deals safety security aspects regarding communication components health modules authentication nimble aimed increasing overall mobility scenarios strongly actuating inherent communications application field paper details every aspect hamster presents plus end two case studies first one consists evaluation five communications schemes internal communications airplanes second one cryptographic evaluation two elliptic curve cryptography algorithms
development mobile computing cloud computing distributed computing meets growing individual service needs facing complex application system urgent problem ensure real time dynamic fine grained data access control analyzing common data access control models basis mandatory access control model paper proposes service oriented access control model regarding system services subject data databases object model defines access levels access identification subject object ensures system services securely access databases
many patients undergoing chemotherapy radiotherapy cancer increased risk developing cardiovascular diseases recent evidence suggests cardiac dysfunction subsequent heart failure mainly due vascular toxicity rather due myocyte toxicity however vascular toxicity cancer therapies explained epicardial coronary artery disease fact last decades found myocardial ischemia may occur consequence structural functional dysfunction complex network vessels seen coronary angiography coronary microcirculation nowadays many diagnostic therapeutic options available coronary microvascular dysfunction cardio oncology aim review suggest future theranostic implications relationship cardiotoxicity oncology coronary microvascular dysfunction showing common pathophysiologic mechanisms proposing new diagnostic approaches therapeutic options cardioprotection
ideas commonly described using metaphors bright idea appears like light bulb seed idea takes root however little known metaphors may shape beliefs ideas role effort versus genius creation important omission given known motivational consequences beliefs explore whether light bulb metaphor although widespread intuitively appealing may foster belief innovative ideas exceptional occurrences appear suddenly effortlessly inferences may particularly compatible gendered stereotypes genius male across three experiments find evidence metaphors influence judgments idea quality perceptions inventor genius moreover effects varied inventor gender reflected prevailing gender stereotypes whereas seed light bulb metaphor increased perceived genius female inventors opposite pattern emerged male inventors
paper establishes capacity region class source coding function computation setups sources information available nodes tree function sources must computed root capacity region holds function long sources joint distribution satisfies certain markov criterion criterion met particular sources independent result recovers capacity regions several function computation setups include point point communication setting arbitrary sources noiseless multiple access network conditionally independent sources cascade network markovian sources
amyloid precursor protein app metabolism engages neuronal endolysosomal pathways processing secretion alzheimer disease dysregulation app leads excess neuronal dysfunction suggesting neuronal app trafficking targeted therapeutic gain cathepsin catb lysosomal cysteine protease lower levels however whether catb modulation improves learning memory function deficits known end progenitor neurons infected recombinant adenovirus expressing catb recovered cell lysates subjected proteomic analyses results demonstrated lamp deregulation linkages catb neuronal phagosome network hippocampal injections adeno associated virus expressing catb reduced levels increased lamp improved learning memory findings associated emergence fos cells results support idea catb speed metabolism lysosomal pathways reduce associated memory deficits
objectives chronic pain total knee replacement tkr uncommon preoperative impaired conditioning pain modulation cpm used predict chronic postoperative pain interestingly exercises reduce pain sensitivity patients knee osteoarthritis koa pilot study investigated association exercise induced hypoalgesia eih cpm post tkr pain relief methods months post tkr patients chronic koa performed cold pressor test nonaffected leg exercise conditions bicycling isometric knee extension randomized counterbalanced cold pressor test exercises test stimuli applied extract pain sensitivity difference computer controlled cuff inflation affected lower leg participants detected cuff pain threshold cppt subsequently cuff pain tolerance cptt manual pressure pain thresholds ppts legs arm shoulder clinical pain intensity numerical rating scale nrs psychological distress questionnaires assessed results clinical pain intensity psychological distress cppt ppt affected leg improved post tkr compared pre tkr preoperatively cpm bicycling eih assessed increase cptt correlated reduction nrs pain scores post tkr improved cpm eih responses tkr significantly correlated reduction nrs pain scores post tkr discussion koa patients hypoalgesia cold pressor stimulation aerobic exercise assessed preoperatively cuff algometry associated pain relief months tkr eih novel preoperative screening tool investigated larger studies
renovation building instead raising new structure scrutinized closely present sustainable alternative reaping benefits improving building energy performance mitigating physical deterioration extent benefits would dependent optimal renovation time determined building owner decision making process unfortunately studies explored improvement decision making process determining appropriate renovation time making difficult building owners conduct reliable cost effective renovation planning model estimates optimal cost effective renovation time building therefore would valuable tool model introduced paper addresses need applying model actual renovation project case study model yielded renovation alternatives achieving cost effective renovation time optimal alternative identified based economic analysis building owner perspective
rationale lowest threshold content dose nicotine discriminated cigarettes may differ due menthol preference objectives menthol non menthol spectrum research cigarettes differing nicotine content used determine discrimination thresholds methods dependent smokers preferring menthol non menthol brands tested ability discriminate cigarettes matched menthol preference nicotine contents one per session ultra low cigarette controlled exposure cigarette four puffs trial number sessions determined lowest nicotine content could discriminate trials also assessed subjective perceptions behavioral choice cigarettes relate discrimination responses results controlling fagerstrom test nicotine dependence score discrimination thresholds likely higher nicotine content cigarettes menthol nonmenthol smokers medians respectively compared ultra low threshold subthreshold next lowest cigarettes differed perceptions puff choice menthol preference alter associations notably threshold cigarettes subthreshold increase choice ultra low conclusions threshold discriminating nicotine via smoking may generally higher menthol nonmenthol smokers research needed identify menthol smoking related higher nicotine thresholds verify cigarettes unable discriminated support reinforcement
background early childhood crucial period language development building social skills distinct two processes may impact upon aims current study aimed identify directional associations expressive language ability prosocial behaviour three five years age methods participants included children families enrolled millennium cohort study children expressive language prosocial behaviour assessed three five years age utilizing standardized assessments parent reports cross lagged models used data analysis results better expressive language three years associated increased prosocial behaviour five years support inverse direction association found conclusions children early ability effectively express others may help building better social relationships entry formal schooling programming efforts tailored towards enhancing positive behavioural growth social skills toddler years likely effective expressive language also targeted component toddler skill development
pineal cyst benign affection human pineal gland borderline pathology normality small percentage patients present symptoms surgical treatment indicated highly selected cases melatonin secretion patients pineal cyst pineal cyst resection studied yet effect surgery human metabolism unknown present study examined melatonin cortisol blood glucose secretion profiles peri operatively surgical group patients control group represented asymptomatic patients pineal cyst patient circadian secretion curves melatonin cortisol glycemia acquired analysis melatonin profiles showed expected diurnal pattern night peak patients surgery control group contrast melatonin levels patients surgery minimum throughout whole period cortisol secretion substantially increased patients surgery blood glucose sampling showed statistically significant differences clinical results demonstrated statistically significant headache relief measured visual analogue scale patients surgery despite small number examined patients conclude patients pineal cyst preserved physiological secretion hormone melatonin patients underwent pineal cyst resection experienced loss endogenous pineal melatonin production equated pinealectomy surprisingly cortisol secretion substantially increased patients surgery elsevier ltd rights reserved
method used easily perform human body communication hbc developed proposed method arduino technology used wearable device baseband communication used study baseband communication uses operational amplifier amplify signal generated arduino device uses comparator remove noise study experimented biological tissue equivalent phantom application developed measure temperature confirm transmission reception string successfully transmitted string using hbc simple circuit addition changes impedance voltage electrode measured experimental results confirm effective hbc band
introduction antisynthetase syndrome ass characterised series clinical manifestations myositis fever mechanic hands diffuse interstitial lung disease ild associated positivity antisynthetase antibodies presence ild great extent mark response treatment prognosis patients methods eleven cases patients ass pulmonary involvement monitoring pulmonary monographic consult third level hospital consult described results nine patients presented positivity anti antibody anti four patients hrct pattern showed nsip four uip one cop ground glass opacity percentage accompanied bronchiectasis bronchiolectasis honeycombing functional exploration mainly affected dlco positive walking test corticodependence highlighted often requiring immunosuppressive treatment chronically exacerbations patients maintain good prognosis far conclusions patients interstitial lung disease least determination antisynthetase antibodies order identify disease better prognosis interstitial diseases idiopathic pulmonary fibrosis elsevier espana rights reserved
transition precision engineering instrumentation widespread use nanoscale structures thin layers requires improved localization methods measuring depth material unified standards generally accepted methods measuring wear resistance friction coefficient currently available aim work development universal friction machine simplified requirements preparation geometric shape sample opposing disc important requirement equipment method measurement ability measure friction coefficient determination wear resistance coatings hardened layers micron submicron thicknesses another important requirement modeling experiment acyclic friction process close possible real operating conditions components parts conditions successfully realized using method disc plate implementation disk plate method used simplify improve rapid measurement minimize load friction assembly reduce friction pair temperature increase sensitivity improve resistive bridge thermal stabilization complex study friction wear processes various materials pairs conditions close operational manufactured tested measuring console low value parasitic load measuring cell designed computerized hardware software system registration friction parameters process developed software processing storage experiment results developed software compatible modern windows operating systems file format measurement results storage compatible conventional graphic editors could processed means excel main principles analysis processing results consequentially described typical results usage developed machine friction coefficient measurements determination wear resistance massive homogeneous surface hardened materials alloys coatings shown high efficiency created equipment complex investigation coatings optimization coating depositing processes modification surface layers shown study efficiency complex confirmed study modified layers micron thickness coatings found friction coefficient wear resistance construction materials modified thin microcrystalline layers nanostructured coatings effectively controlled using created complex
floating growth process large scale freestanding tio nanorod films gas liquid interface investigated basis experiments self templated growth scenario developed account self assembly process scenario titanium complexes function source growth tio also soft template provider floating growth according scenario several new recipes preparing freestanding tio nanorod films gas liquid interface developed freestanding film applied lithium ion battery binder free conducting agent free anode good cyclability obtained work may pave new way floating freestanding tio semiconductor materials great potential basic science also applications materials engineering ion battery photocatalyst dye sensitized solar cell flexible electronics
proton therapy type radiation therapy used treat cancer provides localized particle exposure types radiotherapy ray electron thus reducing damage tissue surrounding tumor reducing unwanted side effects developed novel discrete difference equation model spatial temporal dynamics cancer healthy cells application proton therapy treatment course specifically model simulates growth diffusion cancer healthy cells surrounding tumor one spatial dimension tissue depth treatment tumor discrete bursts proton radiation demonstrate use data vitro clinical studies parameterize model specifically use data studies hepatocellular carcinoma common form liver cancer using parameterized model compare ability different clinically used treatment courses control tumor results show treatment courses use conformal proton therapy targeting tumor multiple angles provides better control tumor using lower treatment doses non conformal treatment course thus recommend use feasible
otilonium bromide spasmolytic drug successfully used treatment irritable bowel syndrome ibs efficacy attributed block type channels muscarinic tachykinin receptors smooth muscle furthermore healthy rats repeated administration modified neurotransmitter expression function suggesting mechanisms action basis investigated whether repeated treatment prevented functional neurochemical changes observed colon rats underwent wrap restrain stress wrs psychosocial stressor considered suitable reproduce main ibs signs symptoms control wrs wrs rats functional parameters measured vivo morphological investigations done vivo colon results showed counteracts neurotransmitters changes caused wrs particular drug prevents decrease nkr nnos vip immunoreactivity increase cgrp crfr contrary affect increase crfr neurons observed wrs rats interfere mild mucosal inflammation due wrs finally per increases expression muscle wall decreases number myenteric chat neurons functional findings show significantly reduction number spontaneous abdominal contraction treated rats ability block type channels also expressed enteric neurons might represent possible mechanism exerts actions
study presents evidence public innovation perspectives politicians public managers environmental antecedents analysed regard impact innovation adoption data drawn survey mayors managers austrian local government results show identify innovation types indicate different antecedents innovation adoption findings managers broadly line results larger jurisdictions since crucial dissimilarities factors explaining adoption innovation suggest politicians managers included future studies local government innovation
across two studies found evidence supporting positive feedback loop positive activities kindness well study participants randomly assigned one four distinct positive activities versus neutral writing activity spending three weeks engaging kind acts found positive activities served triggers predicted greater prosocial effort turn predicted greater well immediately following intervention two week follow study explored specific effects gratitude trigger extended intervention period six weeks although replicate direct effect gratitude trigger prosocial effort people wrote gratitude letters versus writing week reported relatively greater elevation predicted greater prosocial effort six weeks turn replicating study greater effort predicted higher well immediately following study
background transition whole exome whole genome sequencing wes wgs research setting routine clinical practice remains challenging objectives almost previous research specifically assessing interface designs functionalities wes wgs software tools authors set ascertain perspectives healthcare professionals distinct domains optimal clinical genomics user interfaces methods series semi scripted focus groups structured around professional challenges encountered clinical wes wgs conducted bioinformaticians clinical geneticists genetic counselors general physicians results contrary popular existing system designs bioinformaticians preferred command line graphical user interfaces better software compatibility customization flexibility clinical geneticists genetic counselors desired overarching interactive graphical layout prioritize candidate variants tiered system functionalities relevant user domain made accessible favored system capable retrieving consistent representations external genetic information third party sources streamline collaboration patient exchanges authors identified user requirements toward automated reporting system capable summarizing key evidence based clinical findings among vast array technical details conclusions successful adoption clinical wes wgs system heavily dependent ability address diverse necessities predilections among specialists distinct healthcare domains tailored software interfaces suitable group likely appropriate current popular one size fits generic framework study provides interfaces future intervention studies software engineering opportunities
paper aim analyze geographical temporal variability disease incidence spatio temporal count data excess zeros end consider random effects zero inflated poisson models investigate geographical temporal patterns disease incidence spatio temporal models employ conditionally autoregressive smoothing across spatial dimension spline smoothing temporal dimension proposed analysis complex models computationally difficult frequentist perspective hand advent markov chain monte carlo algorithm made bayesian analysis complex models computationally convenient recently developed data cloning method provides frequentist approach mixed models also computationally convenient propose use data cloning yields maximum likelihood estimation conduct frequentist analysis zero inflated spatio temporal modeling disease incidence one advantages data cloning approach prediction corresponding standard errors prediction intervals smoothing disease incidence space time easily obtained illustrate approach using real dataset monthly children asthma visits hospital province manitoba canada period april march performance approach also evaluated simulation study
rosa rubiginosa seed oil studied application skin care products chemical nature seeds pulp even leaves apart oil also relevant view application weed biodiesel production vegetal materials studied infrared spectroscopy ftir differential scanning calorimetry dsc characterisation purposes ftir bands used estimate iodine index suitable biofuels oxidation stability degree viewpoint thermal stability seed oil pyrolysis occurs degrees raw seeds rosehip pulp decomposition temperatures degrees degrees respectively showed potential biomass feedstock conversion biofuels
working day weather passive millimeter wave radiometer widely used remote sensing guidance fields order solve increasingly serious problem water pollution especially pollution caused rapidly breed aquatic plants simple effective method monitor water environment proposed aquatic plants distinguished millimeter wave system high bright temperature compared water radiometer used measure radiation characteristics aquatic plants image simulation results radiation imaging experiments prove feasibility effectively monitoring aquatic plants millimeter wave radiometer study contribute monitoring aquatic plants growth decreasing pollution
past decade engineers studying discussing system identification dramatically improve computational efficiency system identification technique construct mathematical model observed input output data main objective find transfer function solid state relay ssr therefore experimental setup needed find transfer function pulse width modulation pwm control generated using tiva launch pad code composer studio software varied duty cycle step size however switching frequency remained constant since best performance among switching frequencies terms output power total harmonic distortion thd power quality data collected using type thermocouple data acquisition daq labview matlab system identification toolbox used generate transfer function temperature measurement data overall plant duty cycle furthermore transfer function ssr found thus unfound ssr transfer function duty cycles recommended evaluated using different methods transfer functions overall plant successfully validated duty cycle comparing modelling results experimental results using different load rather heater recommended used validate mathematical modelling ssr
predictions different magnetic core losses acceptable accuracy key parameters temperature rise calculations considered rate large hydro electrical machines paper overview existing magnetic core loss models reported new approach computation magnetic stator rotor core loss proposed finite element electromagnetic simulations carried existing hydro electrical generator rating mva poles slots magnetic core losses computed new proposed approach post processing stator rotor finally obtained results compared models available test data
backgroundin new national paediatric asthma management guideline based international global initiative asthma gina guideline launched netherlands studied whether asthma control treatment regimens improved introduction guideline comparing survey data guideline introduction methodstwo comparable groups children years asthma included introduction guideline children parents paediatricians completed questionnaires asthma symptoms medication healthcare use spirometry performed resultsdata patients analysed level asthma control improve proportion partly controlled asthmatics paediatricians characterized children partly controlled children partly controlled according gina criteria step treatment controlled patients applied paediatricians compared step treatment uncontrolled patients improve conclusionsasthma control improve introduction new guideline compared improvement observed step treatment patients controlled disease
semantic web applications reasoning engines data intensive commonly materialise inferences speed processing query time however evolving systems smart environments semantic based context aware systems scas social software user generated data knowledge grow monotonically newer facts may contradict older ones knowledge may deprecated discarded updated knowledge must sometimes retracted describing technique retract explicit inferred statements information becomes obsolete well retracting statement would lead get back removed explicit statements technique based owl justifications triggered whenever knowledge base becomes inconsistent system stays consistent state time spite uncontrolled evolution prove termination correctness algorithm describe implementation evaluation proposal
objectivethe epidemiological data diagnostic course patients borderline personality disorder bpd limited used nationwide register investigate diagnostic stability changes time methodthe danish nationwide registers used follow patients diagnosis bpd investigate first ever psychiatric diagnosis latest diagnosis time period found diagnostic stability described diagnostic changes resultsa total patients diagnosed bpd identified prospective diagnostic stabilities females males retrospective stabilities females males patients received diagnoses bpd first ever diagnosis stress related depressive disorders frequent first ever diagnosis latest diagnosis remained bpd nearly half females one third males followed schizophrenia notably longer follow males conclusionthis study gives detailed display complicated clinical trajectories low diagnostic stabilities demonstrate heterogenous patient group diagnosed many psychiatric diagnoses time copyright john wiley sons ltd
work obtains disguise version exact solitary wave solutions generalized dimensional zakharov kuznetsov benjamin bona mahony regularized long wave equation free parameters via modified simple equation method mse usually method give solution balance number one apply mse method successfully different way carry solutions nonlinear evolution equation balance number two finally graphical results velocity profiles presented different values material constants shown method without help symbolic computation provide straightforward powerful mathematical tool solving nonlinear evolution equation national laboratory aeronautics astronautics production hosting elsevier
meet greenhouse gas emission targets global national sector level reduction opportunities explored embodied operational carbon built environment one underexploited option reduce embodied carbon reuse structural steel however work sansom avery suggests picture declining levels reuse paper explores case identifying practical barriers structural steel reuse series semi structured interviews construction industry members whilst many identified barriers five practical barriers prioritised significant cost availability storage client demand traceability supply chain gaps lack integration contrast commonly identified global literature cost supply chain gaps integration risk jointing technique composite construction time deconstruction two overlaps cost supply chain gaps integration many barriers literature technical focus reducing salvage yield rather completely preventing reuse differing largely systemic barriers interviews prioritised systemic barriers need dealt first increase reuse rates require coordinated approach across construction supply chain building interview insights paper proposes four mechanisms overcome systemic barriers creation database suppliers reused section availability demonstration client demand technical guidance education construction industry government leadership together mechanisms would improve reuse rates reduce embodied emissions built environment play crucial role meeting greenhouse gas emissions reduction targets elsevier ltd rights reserved
crohn disease chronic inflammatory disease digestive tract approximately patients require surgical intervention within years initial diagnosis despite advanced medical treatment alternatives including biologics immune suppressive drugs steroids refractory medical treatment patients common indication surgery unfortunately surgery cure disease minimally invasive treatment modalities suitable patients due benign nature disease especially time index surgery however laparoscopic management fistulizing recurrent disease controversial intractable fibrotic strictures obstruction fistulas abscess formation hemorrhage surgical indications recurrent also complicating laparoscopic treatments nevertheless laparoscopy performed selected patients safety may provide better outcomes compared open surgery common complication laparoscopic intervention postoperative ileus seems may strongly relate excessive manipulation bowel dissection additionally unsuccessful laparoscopic attempts requiring conversion open surgery major concern due presumed risk worse outcomes however recent data show conversions worsen outcomes colorectal surgery experienced hands conclusion laparoscopic treatment modalities recurrent patients promising outcomes used selectively
unsteady friction modeling widely studied transient pipe flows influences modification effect pressure waves feature great importance particularly pipe systems extreme pressure values due overlapping pressure waves generated different sections paper investigates relevance unsteady friction term considering different models available literature particular attention focused following two commonly used one dimensional models weighting function based wfb model instantaneous acceleration based iab model investigation executed using laboratory experiments field tests well numerical simulations simple pipeline systems realistic ranges initial pretransient conditions geometrical characteristics considered data collected experimental tests first used calibrate unsteady friction models investigation validated models applied identify respective domains applicability limitations differences models data measured using local transient analysis lta norm integral total energy ite norm along pipeline reasons discrepancies explored paper practical implications use improvements different unsteady friction models transient pipe flow simulations discussed paper american society civil engineers
background sleep reported important factor bone metabolism sympathetic nervous system activity reported regulate bone metabolism study evaluated association sleep sympathetic nervous system activity bone mass methods study subjects individuals males females mean age years divided two groups slept less day short sleep group slept longer normal sleep group groups compared regard lifestyle cortical bone thickness cancellous bone density bone metabolism markers blood leptin levels sympathetic nervous system activity evaluated heart rate variability analysis results significant differences observed two groups cortical bone thickness blood tracp leptin levels ratio index sympathetic nervous system activity higher group group significant negative correlations observed cortical bone thickness ratio leptin levels significant positive correlation observed ratio leptin levels conclusions short sleep associated decline cortical bone thickness due promotion bone resorption sympathetic nervous system hyperactivity middle aged group leptin levels cortical bone thickness found closely related suggesting cortical bone mass may regulated via interaction leptin sympathetic nervous system elsevier rights reserved
nonlinear load displacement normal stress distribution composite sandwich beams made unidirectional carbon epoxy facings pvc foam cores bending studied carbon epoxy initial linear response exhibits stiffening nonlinearity tension softening nonlinearity compression longitudinal strength tension higher compression foam core also presents nonlinear stress strain response obtained load displacement behaviour beam initial linear part linear behavior modeled incremental strength materials nonlinear analysis theoretical predictions good agreement experimental results furthermore obtained neutral axis sandwich beams bending pass centroid cross section displaced toward tensile side beam experimental results moire measurements plane horizontal displacements core material corroborated analytical predictions findings imply higher compressive smaller tensile stresses core predicted facings identical stress strain behaviour tension compression taking consideration failure analysis sandwich beams
aimswhen skin dysbiosis occurs result skin disorders probiotics act modulators restoring microbial balance several properties selected probiotics evaluated topical application could considered methods resultsadhesion antimicrobial quorum sensing antibiofilm assays carried several probiotic strains tested selected skin pathogens tested strains displayed significant adhesion keratin lactobacilli exception lactobacillus delbrueckii showed antimicrobial activity skin pathogens mainly due organic acid production also prevented biofilm formation propioniferax innocua able break mature biofilms conclusionsthis study demonstrates although tested probiotics adhered human keratin showed limited ability prevent adhesion potential skin pathogens tested probiotics successfully prevented biofilm formation suggesting may successfully used future complement conventional therapies treatment range skin disorders significance impact studythe topically used probiotics may natural targeted treatment approach several skin disorders complement conventional therapies present many undesirable side effects
background implementing quality improvement hospitals requires multifaceted commitment leaders including financial material personnel resources however little known interactional resources needed project implementation aim analysis identify types interactional support hospital teams sought surgical quality improvement project methods hospital site visits conducted using combination observations interviews focus groups explore implementation surgical quality improvement project twenty six site visits conducted october august total hospitals agreed participate interviews recorded transcribed coded themes using inductive analysis results interviewed respondents conducted additional focus groups respondents reported needing following types interactional support implementation quality improvement interventions critical outside perspective implementation progress opportunities learn peers especially around clinical innovations external validation help establish visibility commitment project conclusions quality improvement hospitals clinical endeavor social endeavor findings show teams often desire interactional resources implement quality improvement initiatives person site visits provide resources also activating emotional energy teams builds momentum sustainability quality improvement work implications policymakers quality improvement leaders benefit developing strategies maximize interactional learning feedback quality improvement teams research investigate effective methods meeting needs
silicon glass devices widely used industry mems solar energy system reliability simplicity manufacturing process trend toward wafer level chip scale package wlcsp technology suitable dicing method silicon glass bonded structure wafer become necessary paper combined experimental computational approach undertaken investigate feasibility cutting sandwich structure glass silicon glass sgs wafer laser induced thermal crack propagation litp method semiconductor laser cutting system double laser beams could simultaneously irradiate top bottom sandwich structure wafer designed mathematical model describing physical process interaction laser sgs wafer consists two surface heating sources two volumetric heating sources established temperature stress distribution simulated using finite element method fem analysis software abaqus crack propagation process analyzed using integral method fem model stationary planar crack embedded wafer integral values around crack front edge determined using fem verification experiment typical parameters conducted crack propagation profile fracture surface examined optical microscope explained stress distribution integral value elsevier ltd rights reserved
complete visualization method virtual liver lesion model proposed taking patients abdomen slices data source firstly gradient vector flow snake algorithm combines region force adopted fast accurately extract contour points patients slices cloud data contour points simplified uniformly distance field based method distribution field fitting spline surface presented fast establish lesion model roughly interactive node fine tuning method interactive marching nodes proposed model optimized according requirements users finally realistic lesion model generated texture mapping experiments suggest approach suitable various kinds lesions whole process taking minutes generated model high precision significance study virtual surgeries
paper construction low cost data acquisition system based code generator tools built shown microcontroller key component used read analog digital converter receives instructions client applications microcontroller runs platform independent code accessed clients common corba web services servers bind servers bind server translates high level requests coming clients simple ones dedicated microcontrollers bind embedded servers generated code generators built generated embedded server code size compilation small making possible written limited devices microcontrollers data acquisition system organized service oriented soa fashion consists several modules modules read periodically battery output voltage system built store database modules fire alarms data predefined limits end graph data obtained function time shown
reversible data hiding rdh extract secret messages restore original image without distortion reversibility benefits many practical applications medical image processing multimedia archive management high image quality histogram modification applied rdh many literatures paper two dimensional histogram prediction error expansion integrated well designed difference pair mapping dpm improve embedding capacity according simulation results proposed rdh scheme outperforms existing approaches also based two dimensional histogram average image quality improved embedding capacity maintaining image quality embedding capacity improved approximately bits
evaluate aquatic macrophyte species indicator organism heavy metal pollution bio monitoring studies aquatic ecosystem studied aim study determining heavy metal accumulation aquatic plants lower sakarya river basin located northwestern turkey study performed collecting aquatic plants research area poyrazlar lake taskisigi lake sapanca lake acarlar longoz december solution process plants performed amounts determined icp oes device determination seven elements samples performed icp oes experimental results comply reported values literature according analysis heavy metal concentration plants sakarya river basin range amounts could detected regional accumulations interpreted identifying pollution maps metal
rice oryza sativa one important staple foods half global population many rice traits quantitative complex controlled multiple interacting genes thus full understanding genetic relationships critical systematically identify genes controlling agronomic traits developed genome wide rice protein protein interaction network riceppinet using machine learning structural relationship functional information riceppinet contained predicted interactions non transposable element related proteins power network discovering novel protein interactions demonstrated comparison publicly available protein protein interaction ppi prediction methods experimentally determined ppi data sets furthermore global analysis domain mediated interactions revealed riceppinet accurately reflects ppis domain level studies showed efficiency riceppinet based method prioritizing candidate genes involved complex agronomic traits disease resistance drought tolerance approximately times better random prediction riceppinet provides expanded landscape computational interactome genetic dissection agronomically important traits rice significance statement genome wide rice protein protein interaction network developed using machine learning structural evidence functional information provides expanded landscape protein interactome help plant biologists better understand complex agronomic traits rice
backgroundclinical presentation nonsteroidal anti inflammatory drugs exacerbated respiratory disease nerd found heterogeneous study classified phenotypic clusters determine nerd subtypes methodswe performed two step cluster analysis using urticaria chronic rhinosinusitis crs atopy nerd cohort comprising patients asthma exacerbation defined receiving least one burst intravenous steroid treatment least two bursts oral steroid use days per year possession rate anti asthmatic medications estimated follow period resultsthere four subtypes subtype nerd crs atopy urticaria subtype nerd crs urticaria atopy subtype nerd without crs urticaria subtype nerd urticaria significant differences found four subtypes female proportion baseline fev serum total ige level sputum peripheral eosinophil count higher frequency asthma exacerbations noted subtype compared subtype possession rates medium high dose inhaled corticosteroids long acting beta agonists showed significant differences among four subtypes metabolomic analysis showed four subtypes nerd higher serum leukotriene lte level aspirin tolerant asthma patients subtypes higher urine lte level subtype conclusionwe found four distinct subtypes different clinical biochemical findings asthma exacerbations nerd cohort findings suggest stratified strategies applying subtype classification may help achieve better outcomes management nerd
aimto examine predictive ability memory deterioration grip strength disability progression among utilized home help service methodswe prospectively followed cohort community dwelling older people aged years older certified support level care level home help service users provided consumers cooperatives aichi kanagawa prefecture memory capability grip strength chronic conditions indices surveyed baseline disability progression defined certified care level higher institutionalization year follow resultswe assessed older adults included excluded multivariate cox regression analyses higher eligibility level memory deterioration independently associated higher hazard ratio chronic conditions entered model cancer low grip strength additionally associated conclusionsthe findings present study show memory deterioration risk factor disability progression also grip strength might risk factor consideration chronic conditions cause effect relationship factors disability progression would future challenging issue geriatr gerontol int
green building certifications aim achieve sustainable buildings healthy energy saving environmentally friendly construct healthy built environments occupants high indoor environment quality ieq maintained goal paper analyze extent indoor air quality iaq subset ieq taken account green building certifications worldwide thus iaq requirements reviewed green building certifications countries worldwide certification programs include countries asia europe americas oceania africa fifty five green building schemes selected among certifications rating systems commonly used green building schemes evaluate capability level building achieve life cycle sustainability average contribution iaq green building schemes worldwide volatile organic compounds vocs formaldehyde carbon dioxide indoor air pollutants frequently considered ozone semi volatile organic compounds svocs mentioned less certifications worldwide emission source control ventilation indoor air measurement three main pathways used green building schemes iaq management certifications include ventilation way manage iaq emission source control included certifications mainly targeted building material emissions indoor air measurement included certifications may optional elsevier ltd rights reserved
distributed denial service attacks produce large volumes spoofed network data manual analysis gigabytes network logs determine source attacks victim ips vulnerability exploitation time consuming error prone cloud computing recently emerged promising technology allows everyday users harness massively parallel processing capabilities commodity machines payas utility service contribution work conceptualization design implementation distributed ddos analysis framework uses power cloud via mapreduce paradigm perform entropy based clustering security analysis key features attack traffic evaluated framework two large publicly available ddos attack datasets moreover achieve speedup analysis modestly sized cluster ten nodes
integrin shown novel candidate target imaging specific therapy non small cell lung cancer previously reported peptide containing novel motif ngxg specifically binds integrin receptor lung cancer cells using one bead one peptide combinatorial library study developed peptide cngegqqc based therapeutic agent labeling radionuclide iodine evaluated characteristics including stability biodistribution antitumor activity safety results showed cngegqqc stable serum furthermore biodistribution cngegqqc determined normal mice rabbits vivo biodistribution studies showed radiolabeled peptide kidney significantly higher organs nude mice bearing lung cancer cell xenografts used vivo model tumor inhibition efficacy studies cngegqqc tumor growth decreased significantly mice receiving labeled peptide compared controls effect labeled peptide blocked unlabeled cngegqqc safety studies showed cngegqqc relatively safe animals without significant toxicity data suggest cngegqqc potential targeted radiotherapeutic agent non small cell lung cancer
background aims oestrogen oestrogen mediated signalling protect hepatitis virus incompletely understood mechanisms aimed ascertain phase hepatitis virus life cycle affected oestrogens methods huh cells infected jfh virus genotype exposed dehydroepiandrosterone testosterone progesterone beta estradiol tested without receptor antagonist fulvestrant dose response curves established calculate half maximal inhibitory concentration values dissect beta estradiol interferes phases hepatitis virus life cycle effects measured hepatitis virus pseudo particle system viral entry subgenomic replicon jfh replicon cell line huh viral replication finally dual step infection model infectious supernatants collected infected cells exposed hormones used infect naive cells results progesterone testosterone showed inhibitory effect hepatitis virus dehydroepiandrosterone mildly inhibitory contrast beta estradiol inhibited infection values nmol fulvestrant reverted inhibition beta estradiol dose dependent manner beta estradiol exerted slight inhibition hepatitis virus pseudo particles effect cells either transiently stably huh cells expressing jfh replicon dual step infection model significant half maximal inhibitory concentration decline occurred primary nmol secondary nmol infections extracellular hepatitis virus rna infectivity reduced higher degree comparison intracellular counterpart conclusions beta estradiol inhibits hepatitis virus acting intracellular receptors mainly interfering late phases assembly release hepatitis virus life cycle
solar battery storage technologies known provide savings customers form reduced electricity charges currently savings determined volume component kwh demand component kva interest grows commercial solar battery storage installations need predict demand charge reductions great aim research determine accuracy reliability ability solar battery storage technologies reducing demand charges results shown simulated commercial scale electricity consumption profile solar able reduce maximum demand across five electricity networks australia coupled kwh battery storage additional reduction experienced battery utilisation strategy shown critical yielding greater demand reduction battery storage notably shown ergon energy electricity network battery storage able supply demand lower cost network able results detail first instance demand reduction evaluation solar coupled battery storage focusing physical financial outcomes australian context elsevier ltd rights reserved
benefits collaborative learning established gamification methods used motivate students towards achieving course goals educational settings however different users prefer different game elements rewarding approaches static gamification approaches inefficient authors present evidence based method case study interaction analysis means clustering used create gamification preference profiles profiles used create adaptive gamification approaches online learning collaborative learning environments improving static gamification designs furthermore authors discuss possibilities using approach collaborative online learning environments
spontaneously diabetic toni sdt rat rat model nonobese type diabetes mellitus hepatocellular adenomas reported model report hepatocellular adenoma severe fatty change male week old sdt rat fed high fat diet necropsy animal whitish nodular mass approximately diameter right medial lobe histologically mass well demarcated surrounding tissues slightly compressing adjacent hepatic parenchyma widely compartmented fibrous connective tissues mass consisted vacuolated tumor cells resembling hepatocytes solid occasionally trabecular growth pattern abundant neutral lipids positive fat oil red stain ultra structurally moderately dense material contained within vacuoles tumor cells immunohistochemically tumor cells showed increase immunoreactivity number cytokeratin proliferating cell nuclear antigen negative mesenchymal markers findings mass could distinguished hepatocellular hyperplasia diagnosed hepatocellular adenoma rats hepatocellular adenoma accompanied severe fatty change rare first report hepatocellular tumor severe fatty change sdt rat
render future sfr robust safe certain bdbe considered recent years core disruptive accident leading whole core meltdown scenario gained interest researchers various design concepts safety measures suggested incorporated design address low probability scenario core catcher concept particular proved inevitable vessel core retention device sfr safe retention core debris arising severe accident study aims analyse cooling capability innovative design concept core catcher remove decay heat degraded core accident first capability single collection tray established study extended two three collection trays different design concepts transient forms governing equations mass momentum energy conservations along epsilon turbulence model solved finite volume based cfd solver boussinesq approximation invoked model buoyancy sodium study shows single collection tray capable removing decay heat load typical mwe pool type sfr studies carried improve natural circulation sodium around source lower plenum distribute core debris whole core multiple collection trays found double triple collection trays accommodate decay loads provision openings collection trays proved effective improving heat transfer sodium flow well distributing core debris successive plates detailed analysis isotherms velocity field multiple collection trays openings reveals improved natural circulation around collection trays lower plenum three tray core catcher device multiple openings accommodate decay heat whole core meltdown without exceeding safe temperature limits structural material special attention paid space constraint lower plenum incorporating three tray core catcher device elsevier ltd rights reserved
virtual reality augmented reality applications allow users view artificial content surrounding space simulating presence effect help special applications devices synthetic contents production well known process form computer graphics domain pipeline already fixed industry however emerging multimedia formats immersive entertainment applications free viewpoint television ftv spherical panoramic video require different approaches content management quality assessment international standardization ftv promoted mpeg paper dedicated discussion immersive media distribution format quality estimation process accuracy reliability proposed objective quality estimation method verified spherical panoramic images demonstrating good correlation results subjective quality estimation held group experts
pre exposure prophylaxis prep effective preventing hiv among hiv serodiscordant heterosexual couples gender roles may influence perceived personal social risks related hiv prevention behaviors may affect use prep study interviews focus groups conducted individuals mutually disclosed serodiscordant heterosexual partnerships thika kenya sociocultural factors affect adherence prep explored using grounded analysis three factors identified shape perceptions prep gendered power dynamics control decision making household conflicts risk reduction strategies male sexual desire culture bound definitions women work adherence prep partners prep study high however participants articulated conflicting interests related prep connection traditional gender roles successful delivery prep require understanding key social factors particularly related gender dyadic dynamics around hiv serostatus
paper presents industrial application topology optimization combined conductive convective heat transfer problems solution based synergy computer aided design engineering software tools dassault systsmes considered physical problem steady state heat transfer convection simulated using simulia abaqus corresponding topology optimization feature provided simulia tosca following standard workflow design optimization proposed solution able accommodate practical design scenarios results efficient conceptual design proposals several design examples verification results presented demonstrate applicability
objective deep brain stimulation dbs established adjunctive surgical intervention treating parkinson disease motor symptoms surgical targets globus pallidus interna gpi subthalamic nucleus stn appear equally beneficial treating motor symptoms effects nonmotor symptoms clear lower urinary tract symptoms luts common complaint given prior data stn dbs aimed explore potential benefits luts targets methods performed prospective nonblinded clinical trial evaluating luts patients targets pre post dbs using validated urologic surveys participants already slated dbs target selection predetermined study entry luts evaluated using american urological association aua quality life score qol overactive bladder questionnaire oab sexual health inventory men shim results participants underwent stn dbs gpi dbs patients demonstrated moderate baseline luts urologic qol score significantly improved post dbs analyzed target stn showed significant change qol significant differences urologic scores post dbs noted either target conclusion patients moderate luts notable improvements qol luts post dbs total sample stn target may differences dbs effects luts targets require larger blinded studies
frames cmos image sensor column parallel inverter based sigma delta sigma delta adcs proposed paper order improve robustness inverter instead constant power supply two buffers designed provide power supply inverters instead using operational amplifier inverter based switch capacitor circuit adopted low voltage low power sigma delta modulator detailed analysis design optimization provided due use inverter based sigma delta adcs conversion speed improved reducing area power consumption proposed cmos image sensor fabricated cmos process measurement results show random noise rms pixel conversion gain since measured full well capacity pixel cmos image sensor achieves dynamic range total power consumption frame elsevier ltd rights reserved
little known relationship family income children non cognitive socio emotional skill formation important gap skills hypothesized critical link early outcomes adult socioeconomic status paper presents new evidence importance family income formation evolution children non cognitive skills using recent panel dataset tracks children grades findings suggest important divergence non cognitive skills based family income accumulates time seem explained children health status differences elsevier ltd rights reserved
traditionally data warehousing workloads processed using cpu focused clusters make bulk available machines amazon focus improving analytics performance utilize homogenous multi threaded cpu environment optimized algorithms infrastructure increasing availability highly parallel accelerators like gpu xeon phi discrete accelerators types clusters provided opportunity accelerate analytics operations high programming cost due optimizations required fully utilize new pieces hardware work describes analyzes highly parallel relational algebra primitives developed focus data warehousing queries use common opencl framework executed standard multi threaded processors emerging accelerator architectures part work propose set data intensive benchmarks help compare differentiate performance accelerator hardware determine key characteristics efficiently running data warehousing queries accelerators
increasingly aged population worldwide means people living chronic diseases reduced autonomy taking various medications health professionals take consideration managing dermatological problems elderly patients accordingly current research investigating dermatological problems associated loss cutaneous function age cell renewal slows physical chemical barrier function declines cutaneous permeability increases skin becomes increasingly vulnerable external factors geriatric dermatology consequences cutaneous aging lead xerosis skin folding moisture associated skin damage impaired wound healing problems pose significant challenges elderly carers often nurses manage skin care elderly however recently little attention paid developing appropriate evidence based skincare protocols objective paper highlight common clinical problems aging skin provide appropriate advice cosmetic protocols managing review literature using pubmed performed working group six european dermatologists clinical research experience dermatology basic topical therapy restore protect skin barrier function relieves problems associated xerosis prevents aggravating moisture associated skin damage enhances quality life conclusion authors provide physicians practical recommendations assist implementing basic skin care elderly integrated care approach
development advanced semiconductor devices relies heavily technology computer aided design front end process simulators model fabrication devices including different process steps effects ion implantation dopant defect diffusion interaction epitaxial growth stress effects continuum process simulators continue main tool however kinetic monte carlo simulators without lattice become important well need explore new materials silicon sige germanium iii fundamental modeling required compensate missing experimental information initio methods based density functional theory molecular dynamics help address open questions material characteristics extracted explicitly experiments paper give overview multiscale approach advanced process modeling discuss latest progress
field induced soft smart material kind soft matter whose macroscopic properties mechanical optical significantly actively controlled manipulated external field magnetic field electric field temperature light paper briefly review research application progress filed induced soft smart materials recent years discuss development problems trend research area particular focus three typical field induced soft materials smart materials magnetorheological fluid electrorheological fluid temperature light sensitive polymer gel
backgroundboth alcohol specific genetic factors genetic factors related externalizing behavior influence problematic alcohol use little known however etiologic role components genetic risk alcohol related behaviors across development prior studies conducted male cohort twins suggest externalizing genetic factors important predicting heavy alcohol use adolescence whereas alcohol specific genetic factors increase importance transition adulthood report studied twin brothers sisters brother sister twin pairs examine developmental trajectories investigate whether sex cotwin sex effects modify genetic influences methodswe used prospective longitudinal twin data collected ages within population based finntwin cohort study analytic dependent measures alcohol use behaviors included alcohol initiation age intoxication frequency ages alcohol dependence criteria age individual genetic risk alcohol use disorders aud indexed parents cotwin dsm alcohol dependence criterion counts likewise individual genetic risk externalizing disorders ext indexed composite measure parents cotwin dsm conduct disorder antisocial personality disorder criterion counts resultsext strongly related alcohol use behaviors adolescence aud strongly related alcohol problems young adulthood sex twin sex cotwin significantly moderated associations genetic risk alcohol use behaviors across development aud influenced early adolescent alcohol use behaviors females males ext influenced age males females addition associations aud ext intoxication frequency greater among year old females twin brothers conclusionswe found divergent developmental trajectories alcohol specific externalizing behavior related genetic influences alcohol use behaviors early adolescence genetic influences alcohol use behaviors largely nonspecific later adolescence young adulthood alcohol specific genetic influences alcohol use influential importantly within overall trajectories several interesting sex differences emerged found relationship genetic risk problematic drinking across development moderated individual sex cotwin sex aud influenced adolescent alcohol outcomes females males age ext influenced criteria males females addition association genetic risk intoxication frequency greater among year old females male cotwins
geochemical compositions sediments dongshan bay semi enclosed bay southeast coast china obtained identify pollutant sources evaluate anthropogenic impacts last years results indicated metal flux increasing since enrichment factor values suggested slight enrichment proportion anthropogenic changed coal combustion might important contamination source dongshan bay historical variation metal flux reflected economic development urbanization zhangjiang drainage area past years according landsat satellite remote sensing data urbanization area expanded approximately three times delta values organic matter sediments indicated primarily sourced aquatic terrigenous marsh plants nitrogen mainly derived aquatic plants terrigenous erosion however total organic carbon toc contents total nitrogen contents delta increasing since suggested sources nitrogen soil erosion fertilizer sewage addition toc fluxes dongshan bay significantly increased since reflected use fertilizer however toc fluxes significantly decreased past decade environmental awareness increased environmental protection policies implemented elsevier ltd rights reserved
true primary goal diabetes early diagnosis treatment quality life qol term qol still confusing agreed composes four components physical component mental cogitative component psychological social component many articles written addressing four components last five years articles reviews written addressing diabetes coronary arterial disease addressing diabetes renal function addressing diabetes retinopathy addressing diabetic foot ulcers addressing diabetic neuropathy moreover articles dealing diabetic sexual dysfunction correlation diabetes depression diabetes dementia diabetes family functioning diabetes qol indicating worldwide interest order confront metabolic anomaly consequences researchers developed numerous generic disease specific psychometric tools aid psychometric tools scientific community started realize gruesome effect diabetes patients lives diabetic qol becomes worse complications start develop comorbidities coexist dominant amongst complications health related quality life hrqol lowering related risk factors genetic weight birth others coronary arterial disease followed renal failure blindness combination micro macro vascular complications studies sexual dysfunction moreover many comorbidities deteriorate effect diabetes patient life among obesity hypertension dyslipidemia depression arthritis common intriguing field research interaction diabetes depression cases progression dementia many aspects combinations actions researchers microscope regarding improvement hrqol scores studies performed demonstrated little moderate benefit needed draw safe conclusions topic best combination actions optimize hrqol scores
hydroinformatics emerged numerical modelling water expanded range one restricted modelling flows much wider ranging sociotechnical discipline supports stakeholders addressing water related problems however despite numerous advances hydroinformatics current practical research effort still much technocratic techno centric turn may restrict potential hydroinformatics scope reach special issue compilation thirteen papers illustrates developments applications field hydroinformatics marks twenty five years existence hope help raise awareness subject developments applications editorial special issue briefly discuss origin hydroinformatics introduce papers featuring special issue also give way forward future research application
self hosted environments feared business intelligence eventually face resource crunch situation due never ending expansion data warehouses online analytical processing olap demands underlying networking cloud computing instigated new hope future prospects however implemented cloud traffic demand profile look like research attempts answer key questions regards taking cloud cloud hosting demonstrated help simulation opnet comprising cloud model multiple olap application servers applying parallel query loads array servers hosting relational databases simulation results reflected extensible parallel processing database servers cloud efficiently process olap application demands cloud computing elsevier inc rights reserved
efficient airport detection aircraft recognition essential due strategic importance regions targets economic military construction paper novel airport detection aircraft recognition method based two layer visual saliency analysis model support vector machines svms proposed high resolution broad area remote sensing images first layer saliency fls model introduce spatial frequency visual saliency analysis algorithm based cie lab color space reduce interference backgrounds efficiently detect well defined airport regions broad area remote sensing images second layer saliency model propose saliency analysis strategy based edge feature preserving wavelet transform high frequency wavelet coefficient reconstruction complete pre extraction aircraft candidates airport regions detected fls crudely extract many aircraft candidates possible additional classification detected airport regions utilize feature descriptors based dense sift moment accurately describe features aircraft candidates finally object features inputted svm aircraft recognized experimental results indicate proposed method reliably effectively detects targets high resolution broad area remote sensing images also produces robust results complex scenes
background sequence variation gene promoters often associated disease risk study tested hypothesis common promoter variation apom gene associated systemic lupus erythematosus sle risk sle related clinical phenotypes chinese cohort meanwhile investigated expression apolipoprotein apom serum patients systemic lupus erythematosus sle relationship disease activity methods used case control design genotyped sle patients healthy controls apom promoter single nucleotide polymorphism snp genotyping done matrix assisted laser desorption ionization time flight mass spectrometry maldi tof blood serum concentration apom measured enzyme linked immunosorbent assay sle patients controls results average concentration apom serum significantly lower sle patients compared controls apom levels sle patients positive anti dsdna antibodies dramatically lower patients negative anti dsdna antibodies interesting apom levels correlated systemic lupus erythematosus disease activity index sledai scores association apom sle susceptibility detected han chinese cohort conclusions results demonstrated lower apom levels sle patients correlated disease activity
review describe history basic science behind intermittent neuromodulation specifically tibial nerve neuroanatomic suitability approach well logistics efficacy advantages peripheral tibial nerve stimulation ptns idiopathic neurogenic overactive bladder oab populations also discuss less commonly used sacral pudendal genital nerves means intermittent neuromodulation management oab intermittent neuromodulation form ptns approved third line treatment oab affects upwards population usa several studies clinical trials demonstrated effectiveness ptns treating oab benefit decreased cost invasiveness compared chronic implantable neurostimulators explored various patient populations including patients idiopathic neurogenic detrusor overactivity
reaction mechanism generator rmg constructs kinetic models composed elementary chemical reaction steps using general understanding molecules react species thermochemistry estimated benson group additivity reaction rate coefficients estimated using database known rate rules reaction templates core rmg relies two fundamental data structures graphs trees graphs used represent chemical structures trees used represent thermodynamic kinetic data models generated using rate based algorithm excludes species model based reaction fluxes rmg generate reaction mechanisms species involving carbon hydrogen oxygen sulfur nitrogen also capabilities estimating transport solvation properties automatically computes pressure dependent rate coefficients identifies chemically activated reaction paths rmg object oriented program written python provides stable robust programming architecture developing extensible modular code base large suite unit tests computationally intensive functions cythonized speed improvements program summary program title rmg catalogue identifier aezw program summary url http cpc qub summaries aezw html program obtainable cpc program library queen university belfast ireland licensing provisions mit license lines distributed program including test data etc bytes distributed program including test data etc distribution format tar programming language python computer windows ubuntu mac computers relevant compilers operating system unix linux windows ram minimum larger simulations classification external routines rdkit open babel dassl daspk dqed numpy scipy nature problem automatic generation chemical kinetic mechanisms molecules containing solution method rate based algorithm adds important species reactions model rate constants derived rate rules parameters estimated via group additivity methods additional comments rmg software package also includes cantherm tool computing thermodynamic properties chemical species high pressure limit pressure dependent rate coefficients chemical reactions using results quantum chemical calculations cantherm compatible variety initio quantum chemistry software programs including limited gaussian mopac qchem molpro running time simplest molecules several weeks depending size molecule conditions reaction system chosen authors published elsevier
backgroundwhile research investigated negative stereotyping fat body shapes little focused young children understanding mechanisms motivations consequences weight change objectivesto investigate children understanding weight change achieved people motivation weight change consequences weight loss weight gain methodsone hundred children mean age girls read book one main characters male female according child sex either healthy weight overweight afterwards character described gaining losing weight drawings depicted child story either healthy weight overweight presented child discussed audio recorded semi structured interview followed transcripts analysed using thematic analysis resultsnearly children described weight shape change attributed food frequently exercise weight loss viewed positively motivations consequences grouped two master themes physical social reasons clear gender differences observed responses conclusionstalking year olds showed observant knowledgeable especially motivations consequences weight change working improve children health literacy suggests receptiveness early fact based education
recently commercial websites collect browsing history device information use services provide paper focused font information obtained via web browser determine kind software identified given device according existing research possible identify installed applications adobe flash player microsoft office using font information thus examined fonts installed operating systems applications results show font information device used identify installed applications type version
rationale absence surgical lung biopsy patients diagnosed idiopathic pulmonary fibrosis ipf clinical practice could participate inpulsis trials nintedanib honeycombing traction bronchiectasis plus reticulation without atypical features usual interstitial pneumonia uip high resolution computed tomography hrct thus patients trials represented patients definite uip large subgroup patients possible uip objectives investigate potential impact diagnostic subgroups progression ipf effect nintedanib method conducted post hoc subgroup analysis patients honeycombing hrct confirmation uip biopsy versus patients without either using pooled data inpulsis trials measurements main results seven hundred twenty three patients honeycombing biopsy patients honeycombing biopsy subgroups respectively adjusted annual rate decline fvc patients treated placebo nintedanib versus placebo difference adjusted annual rate decline fvc confidence interval confidence interval significant treatment subgroup interaction adverse events similar subgroups conclusions patients ipf diagnosed clinical practice possible uip traction bronchiectasis hrct undergone surgical lung biopsy disease progressed similar way responded similarly nintedanib patients honeycombing hrct confirmation uip biopsy
background evidence benefits online cognitive behaviour therapy cbt based programmes delivered clinical context clear evidence translate online cbt based stress management programmes delivered within workplace context one challenges delivery online interventions programme engagement challenge even acute interventions delivered real world settings workplace purpose pilot study explore effect online facilitated discussion group engagement estimate potential effectiveness online cbt based stress management programme methods study three arm randomised controlled trial rct comparing minimally guided online cbt based stress management intervention delivered without online facilitated bulletin board wait list control group employees six based organisations recruited study inclusion criteria include age years elevated levels stress measured pss scale access computer tablet internet primary outcome measure engagement defined number logins site secondary outcome measures include measures engagement number pages visited number modules completed self report engagement measures effectiveness psychological distress subjective wellbeing possible moderators include measures intervention quality satisfaction acceptability credibility system usability time pressure goal conflict levels distress baseline job autonomy measures taken baseline weeks credibility expectancy measures weeks completion intervention weeks follow primary analysis conducted intention treat principles discussion knowledge first study explore effect online discussion group engagement effectiveness online cbt based stress management intervention study could provide solution growing problem poor employee psychological health begin address challenge increasing engagement internet delivered health interventions
clearance oxidative stress compounds critical protection organism malignancy key physiological process regulated fully understood found expression gprca well characterized tumor suppressor lung cancer elevated colorectal cancer tissues patients cancer cell lines colitis associated cancer model mice found gprca deficiency reduced cell proliferation increased cell apoptosis well inhibited tumorigenesis vivo rna seq transcriptome analysis identified oxidative stress associated pathways dysregulated moreover gprca deficient cells mouse tissues oxidative agents reduced partially due increased glutathione gsh level mechanistically gprca regulates mediated vanin expression predominant enzyme cysteamine generation administration cystamine disulfide form cysteamine gprca deficient cell lines inhibited gcs activity leading reduction gsh level increase cell growth taken together studies suggest gprca potential biomarker colon cancer promotes tumorigenesis stimulation vanin expression oxidative stress colitis associated cancer study revealed unexpected oncogenic role gprca colorectal cancer suggesting complicated functional molecular mechanism differences gene distinct tissues new colorectal cancer crc positively associated chronic inflammation major feature increased production reactive oxygen species ros capable inducing potentially malignant changes cells molecular pathways associated changes however fully elucidated retinoic acid induced protein coupled receptor gprca identified potentially oncogenic player crc whereby elevated gprca expression leads dysregulation pathways responsible clearance oxidative agents gprca deficiency associated reduced cell proliferation human cancer cell lines diminished tumor progression mice
objective evaluate incidence new cases psoriatic arthritis psa patients plaque psoriasis receiving biologic drugs methods retrospective study performed psoriatic patients biologic treatment attending psoriasis care centre dermatology university federico naples january november part routine clinical practice assessment disease activity made baseline every months psa diagnosis performed rheumatologist clinical examination evaluation caspar criteria laboratory radiological assessment results basis inclusion exclusion criteria reviewed analysed clinical data patients plaque psoriasis biologic drugs adalimumab etanercept infliximab ustekinumab prescribed respectively found patients plaque psoriasis developed psa treatment biologic drugs particular psa patients etanercept therapy adalimuniab ustekinumab infliximab conclusion results study show several psoriasis patients biologic therapy may sufficient prevent onset articular involvement verified psa cases arthritis occurred concomitance severe cutaneous involvement
due continuous decrease channel length transistor reduction supply voltages design operational amplifier opamp poses new challenges short channel effects limitations planar mos technologies alternative device structures developed among finfet prominent one hence study wanted explore advantages finfet mosfet analog design hence designed miller compensated opamp using mos finfet devices evaluated parameters like power voltage gain phase margin gain bandwidth product gbw slew rate results show finfet based opamp better mos based opamp many aspects briefed comparison conclusion section paper section paper
richard scheffer wilson features broader autism phenotype people epilepsy support shared mechanisms epilepsy autism spectrum disorder neurosci biobehav rev xxx xxx inform mechanisms underlying comorbidity epilepsy autism spectrum disorder asd conducted meta analyses test whether impaired facial emotion recognition fer theory mind tom key phenotypic traits asd common people epilepsy pwe controls contrasted findings relatives individuals asd asd relatives compared controls furthermore examined relationship demographic age sex epilepsy related factors epilepsy onset age duration seizure laterality origin fer tom thirty one eligible studies pwe including individuals temporal lobe epilepsy asd relatives identified systematic database search analyses revealed reduced fer tom pwe compared controls reduced tom asd relatives tom poorer pwe asd relatives weak associations found fer tom epilepsy related factors findings suggest shared mechanisms epilepsy asd independent intellectual disability elsevier ltd rights reserved
physical activity routine component lifestyle modification program implemented prior bariatric surgery one goals improve patients physical capacity however physical activity intensity recommended meet goal unknown study aimed assess association time spent different physical activity intensities physical capacity patients awaiting bariatric surgery total women men recruited primary outcome physical capacity measured using six objective tests min walk chair stand sit reach unipodal balance eyes open eyes closed hand grip strength tests primary exposure variable physical activity intensity sedentary light moderate vigorous measured accelerometers average body mass index total time spent moderate vigorous intensity time spent sedentary adjusted body mass index age sex four six physical capacity tests significantly associated moderate intensity physical activity beta min walk chair stand balance eyes open hand grip strength min walk associated sedentary activity results suggest physical capacity associated time spent moderate intensity individuals awaiting bariatric surgery next step study increase time spent moderate intensity translate improvements physical capacity
major depressive disorder mdd occurs high prevalence among mental illnesses mdd patients experience sadness hopelessness blunted affective reactivity however depressive episodes also key symptoms depressive disorders like bipolar disorder bpd seasonal affective disorder sad moreover depressive symptoms also found healthy individuals experienced less severe shorter duration patients aimed summarize studies investigating odor perception depression including depressive states healthy individuals patient populations odor perception depression assessed psychophysical methods olfactory sensitivity odor identification discrimination odor ratings intensity emotional valence familiarity addition studies investigated affective reactions odors physiological anatomical correlates odor perception depression summary reveals mdd associated reduced olfactory sensitivity however odor identification discrimination scores seem unaffected depression reduced olfactory sensitivity might associated reduced ability encode olfactory information reduced volume olfactory bulb similar processes seem occur healthy individuals experiencing depressive states observed bpd sad patients however order conclude reduced olfactory sensitivity directly linked depression suggested studies implement control measures cognitive performances perceptual abilities stimulus modalities concluded reduced olfactory performance mdd patients seems disorder modality test specific application appropriate olfactory cognitive test battery might highly useful differential diagnosis mdd
improved fuel efficiency hybrid electric vehicles requires delicate balance internal combustion engine usage battery energy using carefully designed energy management control algorithm numerous energy management strategies hybrid electric vehicles proposed literature many centered equivalent consumption minimisation strategy ecms owing potential online implementation key challenge equivalent consumption minimisation strategy lies estimating adapting equivalence factor real time reasonable fuel savings achieved without depleting battery state charge end defined driving cycle address challenge paper proposes novel state charge feedback ecms controller simultaneously optimises selects adaption factors proportional controller gain initial equivalence factor single parameters applied real time driving cycle unlike existing state charge feedback methods approach solves conflicting multiple objective optimisation control problem thus ensuring obtained adaptation factors optimised robustness charge sustenance fuel reduction potential proposed approach thoroughly explored number legislative real world driving cycles varying vehicle power requirements results showed whilst achieving fuel savings range depending cycle final battery state charge optimally controlled within target battery state charge
work presents novel strategy decipher fragments egyptian cartouches identifying hieroglyphs composed cartouche drawing usually inside oval encloses group hieroglyphs representing name monarch aiming identify drawings proposed method based several techniques frequently used computer vision consists three main stages first picture cartouche taken input contour localized second stage hieroglyph individually extracted identified finally cartouche interpreted sequence hieroglyphs established according previously generated benchmark sequence corresponds name king although method initially conceived deal high low relief writing stone also applied painted hieroglyphs approach affected variable lighting conditions intensity completeness objects proposal tested images obtained abydos king list egyptian monuments archaeological excavations promising results give new possibilities recognize hieroglyphs opening new way decipher longer texts inscriptions particularly useful museums egyptian environments additionally devices used acquiring visual information cartouches smartphones part navigation system museums users located indoor environments means combination wifi positioning systems wps depth cameras unveiled end document
numerous studies suggested substantial genetic contribution etiology primary form restless legs syndrome rls periodic leg movements plm describe symptoms sleep profiles physiological parameters two families several members present rls plm proband family year old woman proband family year old woman exhibited symptoms since age years patients families diagnosed rls according criteria international rls study group polysomnographic recordings performed quantify describe plm sleep sleep parameters showed decreased sleep efficiency increased sleep latency arousal index presence plm subjects one families showed exact profile dominant inheritance anticipation age onset family founders blood relatives affected member third generation suggesting recessive mode inheritance rls plm prevalent sleep disorder affecting population one substantially impairs healthy sleep patterns efforts understand underlying pathophysiology contribute improve sleep life quality patients
background needle exchange programs safe highly effective programs promoting health among people inject drugs however remain poorly funded often illegal many places worldwide due fear stigma surrounding drug use continued advocacy education implementation new needle exchanges thus essential improve public health reduce structural inequality commentary argue students especially professional graduate students potential play important role advancing harm reduction students benefit respect given professions training enter gives leverage navigate political hurdles often faced needle exchange organizers especially areas presently lack services addition due relative simplicity needle exchanges require much licensing clinical knowledge infrastructure associated traditional student programs student run free medical clinics students capable learning harm reduction cultural approaches techniques remain humble open minded seek help harm reduction community consequently students generate tremendous benefits community without performing beyond appropriate clinical limitations students benefit organizing needle exchanges gaining applied experience advocacy organization building political finesse working needle exchange significantly helps erode stigma multiple marginalized populations students health related professions additionally learn clinically relevant knowledge often lacking formal training understanding structural violence inequality root causes substance use client centered approaches health services interacting clients peers rather standard hierarchical medical interaction conclusion therefore encourage students learn consider organizing needle exchanges training experience students successful developing sustainable programs benefit clients broader harm reduction movement alike
context doubly fed induction generator dfig connected utility grid unbalanced voltage conditions controller design needs ensure additional challenges restricting total harmonic distortion thd grid current minimizing pulsations generated power torque link voltage etc apart facilitating generator power control study negative sequence compensation scheme magnetizing current dfig investigated reference currents modified include negative sequence compensating component magnetizing current rotor side converter employed compensate pulsations magnetizing current thereby minimizing ripple power torque grid side converter used maintain unity power factor constant link voltage revealed controlling magnetizing current single control target enables simultaneous reduction pulsations torque power link voltage also minimizes unbalance currents effectiveness scheme validated detailed analysis numerical simulations pscad emtdc practical dfig wind generation system experimental results dfig test setup typical experimental results laboratory test setup show improved performance
dynamic weighing weighing objects motion without stopping weighing platform allows one increase rate operation automatic weighing systems used industrial production processes without compromising accuracy since classical identification based approach dynamic weighing based second order mass spring damper model weighing system yield satisfactory results applied conveyor belt type checkweighers several extensions technique examined experiments confirm appropriately modified identification based approach becomes reliable tool dynamic mass measurement checkweighers elsevier ltd rights reserved
paper introduces error terms calibration model algorithm vector network analyzer vna based signal flow graph theory mason formula proposes full port calibration method influence error caused measuring non insertable duts vna measuring results analyzed corresponding compensation algorithm given meanwhile paper discusses transmission measurement error affected respectively hardware performance vna reflection coefficient transmission coefficient calibration kit parameters dut finally algorithm eliminate unknown presented
unintended pregnancy continues substantial public health problem emergency contraception provides last chance pregnancy prevention several safe effective options emergency contraception currently available yuzpe method combined hormonal regimen essentially replaced oral medications including levonorgestrel antiprogestin ulipristal antiprogestin mifepristone studied use emergency contraception effective postcoital method contraception copper intrauterine device iud obesity simultaneous initiation progestin containing contraception may decrease effectiveness emergency contraception
background measuring food intake rodents conceptually simple yet labor intensive temporally imprecise task commonly food weighed manually interval hours days measurements commercial feeding monitors excellent costly require specialized caging equipment new method developed feeding experimentation device fed low cost open source home cage compatible feeding system fed utilizes arduino microcontroller open source software hardware fed dispenses single food pellet food well monitored infrared beam mouse removes pellet fed logs timestamp secure digital card dispenses new pellet well post hoc analyses pellet retrieval timestamps reveal high resolution details feeding behavior results fed capable accurately measuring food intake identifying discrete trends light dark cycle feeding additionally show utility fed measuring increases feeding resulting optogenetic stimulation agouti related peptide neurons arcuate nucleus hypothalamus comparison existing methods cost similar per device fed cheaper commercially available feeding systems fed also self contained battery powered designed placed standard colony rack cages allowing monitoring true home cage feeding behavior moreover fed highly adaptable synchronized emerging techniques neuroscience optogenetics demonstrate conclusions fed allows accurate precise monitoring feeding behavior home cage setting published elsevier
bipolar disorder associated increased risk tobacco dependence leading addictive substance worldwide toll like receptor sensor pathogens products cellular stress damage major innate immune molecule logical candidate gene tobacco dependence involvement tlr molecules several substance use disorders suggested association tlr gene analysed herein potential association six tlr polymorphisms lifetime tobacco smoking patients significant association tobacco smoking found genotype cochrane armitage trend test corrected alleles corrected minor allele associated protective effect even adjusting confounding factors results suggest tlr gene polymorphism may act intermediate factor association tobacco smoking addiction elsevier rights reserved
article analyzes parameters stability secondary electrical circuits variable speed pump storage unit differential equations laplace transformation describing operation equations transfer functions dynamic mathematical model exciter control system additional factors transferring units installing structure circuit dynamic model dynamic mathematical model variable speed pump storage unit comparing standard mathematical models ieee investigation stability instability secondary electrical circuits variable speed pump storage unit created methodology testing
accessible summary known subject learning disability nursing area people learning disability offending background developed considerably recent years particularly since publication bradley limited work competencies nurses require work area even less personal attributes learning disability nurses learning disability nursing specific contribution care population lies knowledge interaction learning disability individual sometimes abusive personal history understanding subsequent offending behaviour knowledge base nurses working people learning disabilities offending background needs reflect changing service user group particularly relation substance misuse borderline personality disorder mental health way factors inter relate learning disability implications practice research required relationship among decision making risk taking reluctance personal attributes required nurses work secure learning disability care learning disability secure services likely continue undergo change circumstances alter offending population demonstrate greater complexity nursing competencies personal attributes need similarly adapt changes mental health nursing great deal contribute effective working population specifically regard developing strong relationships concerns around borderline personality disorder substance misuse particularly evidence abstract aim identify discuss personal attributes required learning disability nurses work effectively people offending background secure community settings background study part larger research investigation nursing competencies required work people offending background existing studies examining personal attributes necessary working group design qualitative study addressing perceptions nurses around personal attributes required work people learning disabilities offending background methods semi structured interview schedule devised constructed individual interviews subsequently undertaken learning disability nurses working high medium low secure community settings data collected year analysed using structured thematic analysis supported software package maxqda findings thematic analysis produced three categories personal attributes named looking deeper achieving balance connecting contained three sub categories conclusion nursing learning disability offending background continues develop interplay among personal history additional background factors nurses personal attributes learning disability critical effective relationship building
mouldboard plough complex geometry surface determines tillage quality power consumption paper illustrates advanced analytical method combined computer aided design software order study effect geometric parameters alpha beta surface design cylindroidal mouldboard plough comparison cylindroidal cylindrical mouldboard plough investigated effect geometric parameters beta study shows increase cutting angle alpha lifting angle beta generates different mouldboard ploughs larger cutting edge produce uprising mouldboard plough body relative direction tillage respectively increases consumed energy however increase geometric parameters reduces radius curve mouldboard plough directly affects inversion process soil consumed energy comparison cylindroidal cylindrical mouldboard plough shows reversion process soil done delay case cylindrical mouldboard plough
landslide barrier lakes usually form quickly disasters require timely remote sensing images monitor land cover change however cloud free images always available emergency situations paper provides method fuse multitemporal cloud covered images change detection based evidential fusion framework first frame discernment defined postclassification comparison results second way measuring basic belief assignment bba introduced based confusion matrixes next simple bba redistribution process proposed deal cloud coverage problems complementary redundant information input images fused following evidence combination decision making rules evidential fusion framework finally land cover change map derived thanks dempster shafer evidence theory proposed method complete change detection process including data fusion cloud removal integrated manner proposed method applied detect landslide barrier lake real case study using series cloud covered images satellite result comparisons show proposed method effective basic fusion strategies perform change detection cloud removal separate steps approaches improve proposed method discussed introducing new evidence combination rule improving classification accuracy adding new evidences results indicate potential evidential fusion change detection cloud covered images
paper study skyline group problem data stream object dominate another object worse object attributes better object least one attribute object dominated object skyline object skyline group problem involves finding item groups dominated item group existing algorithms designed find skyline groups process static data however data changes stream time many applications algorithms designed support skyline group queries dynamic data paper propose new algorithms find skyline groups data stream use data structures namely hash table dominance graph matrix store dominance information update results incrementally conduct experiments synthetic datasets evaluate performance proposed algorithms experimental results show algorithms efficiently find skyline groups data stream
host mining practices produce fine grained mineral sludge mature fine tailing oil sand extraction sludges hard dewater high clay content low hydraulic conductivity paper describes pressure filtration tests eight different nonwoven geotextiles gtxs used filter high clay content sludges sludges formulated mixing kaolinite silt obtain eight different grain size distributions gsds ranging clay content ranging sludges created research gsd variability real fine tailings results indicate sludges filtered nonwoven gtxs selected basis pore opening size furthermore calendered gtxs efficient retaining particles needle punched gtxs addition early stage filtration gtxs really influence filtering stage retaining coarser particles allow progressive formation filter cake upon forming filter cake becomes major contributor particle retention finally sludge composition found significant factor affecting final state dewatering elsevier ltd rights reserved
advances optical microscopy biosensors cell culturing technologies transformed live cell imaging thanks advances live cell imaging plays increasingly important role basic biology research well stages drug development image analysis methods needed extract quantitative information vast complex data sets aim review provide overview available image analysis methods live cell imaging particular required preprocessing image segmentation cell tracking data visualisation methods potential opportunities recent advances machine learning especially deep learning computer vision provide discussed review includes overview different available software packages toolkits published elsevier inc
feasibility using thermomagnetically pumped ferrofluid enhance performance natural convection cooling loop investigated first simplified analytical estimate thermomagnetic pumping action derived design rules optimal solenoid ferrofluid presented design rules used set medium scale case study modeled using previously published validated model aursand results show thermomagnetic driving force significant compared natural convection driving force may cases greatly surpass results also indicate cooling performance increased factors single phase two phase regimes respectively even taking account added heat solenoid performance increases alternatively used obtain reduction heat sink size elsevier rights reserved
paper describes theoretical background electromagnetic induction metal objects modelling response function specific case object shape homogenous sphere ferromagnetic non ferromagnetic material introduced experimental data measured metal detector excited linearly frequency swept signal presented testing target various spheres different materials sizes used results lead better identification buried object
ankle rehabilitation robots recently attracted great attention since provide various advantages terms rehabilitation process viewpoints patients therapists paper presents development evaluation fuzzy logic based adaptive admittance control scheme developed dof redundantly actuated parallel ankle rehabilitation robot proposed adaptive admittance control scheme provides robot adapt resistance assistance level according patients disability level addition fuzzy logic controller flc developed improve trajectory tracking ability rehabilitation robot subject external disturbances possibly occur due human robot interaction boundary scales membership functions flc tuned using cuckoo search algorithm csa classical proportional integral derivative pid controller also tuned using csa examine performance flc effectiveness adaptive admittance control scheme observed experimental results furthermore experimental results demonstrate optimized flc significantly improves tracking performance ankle rehabilitation robot decreases steady state tracking errors compared optimized pid controller performances developed controllers evaluated using common error based performance indices indicating flc roughly better performance pid controller
key escrow problem high computational cost two major problems hinder wider adoption hierarchical identity based signature hibs scheme hibs schemes either escrow free online offline model proved secure previous work however much scheme evaluated experimentally letter several hibs schemes considered study algorithmic complexity schemes theoretically experimentally scheme performance practicability models discussed
aim paper propose decision support tool contractors bidding stage quantify probability delay construction projects turkey using relative importance index rii method incorporated fuzzy logic purpose delay factors identified categorized major groups detailed literature review process well interviews experts construction industry relative importance delay factors groups quantified using relative importance index method ranking factors groups demonstrated according level effect delay delay assessment model proposed using fuzzy set theory taking account delay factors characterized construction projects assessment model developed using commercial software product proposed methodology tested real case study probability delay project evaluated means assessment model required inputs entered software factors groups contribute probability delays discussed depending case study results assessment model results found satisfactory finally recommendations made order minimize control delays construction projects
vision surrounding people within eyeshot influences human well safety rationale system development allows recognizing faces difficult perspectives online informing timely approaching people undisputed manuscript describes methods automatic detection equilibrium face points bitmap image methods forming face model optimal search algorithm equilibrium points chosen method forming face model basing single bitmap image building face image rotated preset angle proposed algorithm estimating angle algorithm face image rotation implemented manuscript also reviews existing methods forming face model algorithm formation face model single bitmap image set individual models proposed well algorithm forming different face angles calculated face model aimed create biometric vectors cluster operation results algorithm face images formation different angles presented published future academy www futureacademy org
work presents techno financial evaluation two chilean locations promising wind potential laguna verde placed central region country porvenir southern region small scale wind farm studied considering nominal electrical production capacity facility comprised three wind turbine models available national market currently tariff method used chile net billing scheme energy bought sold grid different prices study based hypothetical residential households software tool used perform assessment hybrid optimization multiple energy resources homer scenarios results showed net present cost npc instead financial profit proposed projects sensitivity analysis also carried group variables studied npc exhibited sensitive price buying energy grid annual average wind speed finally government policies applications discussed elsevier ltd rights reserved
current study focused dihydrotestosterone dht regulates synaptic plasticity hippocampus mild cognitive impairment male senescence accelerated mouse prone samp mice five month old samp mice divided control castrated castrated dht groups mice castrated treated physiological doses dht period months determine regulatory mechanisms dht cognitive capacity effects dht morphology synapse expression synaptic marker proteins hippocampus investigated using immunohistochemistry qpcr western blot analysis results showed expression camp response element binding protein creb postsynaptic density protein psd synaptophysin syn developmentally regulated brain protein drebrin reduced castrated group compared control group however dht promoted expression creb psd syn drebrin hippocampus castrated dht group thus androgen depletion impaired synaptic plasticity hippocampus samp accelerated development alzheimer disease like neuropathology suggesting similar mechanism may underlie increased risk men low testosterone addition dht regulated synaptic plasticity hippocampus mild cognitive impairment mci samp mice delayed progression disease alzheimer dementia conclusion androgen based hormone therapy potentially useful strategy preventing progression mci aging men androgens enhance synaptic markers syn psd drebrin activate creb modulate fundamental biology synaptic structure lead structural changes plasticity hippocampus result improved cognitive function
report five component autonomous chaotic oscillator jerky type hitherto simplest kind using one operational amplifier key component circuit junction field effect transistor operating triode region provides nonlinear resistor antisymmetrical current voltage characteristic emulating colpitts like chaotic circuit describe experimental results illustrating dynamical behavior circuit addition report numerical simulations model circuit display good agreement measurements
designing fast scalable algorithm mining frequent itemsets always eminent promising problem data mining apriori one broadly used popular algorithm frequent itemset mining designing efficient algorithms mapreduce framework process analyze big datasets contemporary research nowadays paper focused performance mapreduce based apriori homogeneous well heterogeneous hadoop cluster investigated number factors significantly affects execution time mapreduce based apriori running homogeneous heterogeneous hadoop cluster factors specific algorithmic nonalgorithmic improvements considered factors specific algorithmic improvements filtered transactions data structures experimental results show appropriate data structure filtered transactions technique drastically reduce execution time non algorithmic factors include speculative execution nodes poor performance data locality distribution data blocks parallelism control input split size applied strategies factors fine tuned relevant parameters particular application experimental results show cluster specific parameters taken care significant reduction execution time also discussed issues regarding mapreduce implementation apriori may significantly influence performance
introduction many pharmacologic therapies treatment idiopathic pulmonary fibrosis ipf evaluated via randomized placebo controlled clinical trials rcts conducted past two decades therapies shown ineffective even potentially harmful however number recently completed rcts shown significant efficacy pirfenidone nintedanib treatment ipf areas covered manuscript reviews recent advances management ipf forms fibrosing interstitial lung disease ild emphasis ipf material upon discussion based obtained various published texts manuscripts identified via literature searching pubmed expert commentary anti fibrotic drugs available clinical use perceived standard care therapies potential blunt disease progression many patients ipf however agents necessarily stop disease progression significant impact mortality effective pharmacologic therapies needed patients ipf additionally whether anti fibrotic agents effective therapies forms pulmonary fibrosis often radiologic histopathologic manifestations mimic ipf evaluated number rcts
study healing conventional non shape memory syntactic foam embedded shape memory polyurethane fibers investigated per biomimetic close heal strategy syntactic foam made epoxy matrix dispersed volume glass microballoons volume shape memory polyurethane fibers three levels thermoplastic healing agent volume notched beam specimens prepared fractured tension create macroscopic cracks three levels tensile stresses kpa applied fractured beam specimens healing order evaluate healing capability composite service conditions found tensile stress level healing agent content significant effect healing efficiency subjected kpa tensile stress healing efficiency determined peak tensile load high
health benefits playing football importance exercise social contact healthy ageing well established older adults take enough exercise football popular flexible format draws players engrossing effortful social exercise physical demands play full speed may make unsustainable older adults restricted walking pace play still engaging health benefits retained physical demands remain manageable pilot study aims investigate experience older adults playing walking football every week sustainable rewarding intensity locomotor pattern walking football scale nature walking football health benefits possible cognitive benefits playing walking football measures processing speed selective divided attention updating inhibition components executive function walking football waiting list groups compared weeks one hour per week football walking football found engaging sustainable older adults moderately intensive however selective health cognitive benefits found brief intervention
study elucidated potential antidepressant like effect prolonged roprena administration orally daily days using beta amyloid rat model alzheimer disease following gonadectomy experimental model created intracerebroventricular injection beta amyloid gonadectomized gdx rats gdx rats testosterone propionate subcutaneous daily days supplementation roprena administered gdx rats gdx rats treated depression like behavior assessed forced swimming test spontaneous locomotor activity assessed using open field test corticosterone testosterone levels blood serum fst measured experimental groups treatment roprena significantly decreased immobility time gdx rats beta amyloid forced swimming test coadministration roprena exerted markedly synergistic antidepressant like effect gdx rats beta amyloid model depression like behavior testing roprena administered alone together significantly enhanced crossing frequency rearing grooming gdx rats beta amyloid open field test moreover roprena administered alone together significantly decreased elevated corticosterone levels blood serum gdx rats beta amyloid following forced swimming test results indicate roprena marked antidepressant like effect experimental model alzheimer disease male rats altered levels androgens
gli similar glis member kruppel like zinc finger protein subfamily predominantly expressed pancreas thyroid kidney glis mrna initially detected mouse pancreas embryonic day largely restricted beta cells pancreatic polypeptide expressing cells well ductal cells later stage pancreas development mutations glis cause neonatal diabetes syndrome characterized neonatal diabetes congenital hypothyroidism polycystic kidney importantly genome wide association studies showed variations glis strongly associated type diabetes type diabetes multiple populations glis cooperates pancreatic duodenal homeobox pdx maf musculoaponeurotic fibrosarcoma oncogene family protein mafa well neurogenic differentiation neurod potently controls insulin gene transcription glis also plays role beta cell survival likely insulin secretion perturbation functions may underlie three forms diabetes glis synergistically hepatocyte nuclear factor hnf forkhead box foxa controls fetal islet differentiation via transactivating neurogenin ngn impairment function leads neonatal diabetes addition glis also required compensatory beta cell proliferation mass expansion response insulin resistance disrupted may predispose increasing understanding mechanisms glis beta cell development survival function maintenance provide new insights disease pathogenesis potential therapeutic target identification combat diabetes
cortical spreading depression associated activation nmda receptors interact postsynaptic density protein psd binds nitric oxide synthase nnos tested whether inhibition nnos psd nmda receptor complex formation anti ischemic compound uccb tat dimer ameliorates persistent effects cortical spreading depression cortical function using invivo two photon microscopy somatosensory cortex mice show fluorescently labelled tat dimer readily crosses blood brain barrier accumulates nerve cells first hour injection tat dimer suppressed stimulation evoked synaptic activity cortical blood flow cerebral oxygen metabolic cmro responses preserved cortical spreading depression tat dimer reduced average amplitude negative shift direct current potential furthermore compound diminished average depression spontaneous electrocorticographic activity first min post cortical spreading depression recovery mitigate suppressing effect cortical spreading depression cortical blood flow cmro suggest uncoupling psd nmda receptors reduces overall neuronal excitability amplitude spreading depolarization wave findings may interest understanding neuroprotective effects nnos psd uncoupling stroke
association hereditary hemorrhagic telangiectasia hht type hereditary angioedema rare condition medicine case reported muller describes coexistence two diseases emphasizes need listing hht patients liver transplantation case indications occurs presence hcc abnormally increased cardiac output gastrointestinal bleeding reported case case described mueller anecdotal usefulness liver transplantation hht patients shows liver transplantation may best supportive care sometimes unique final therapeutic option patients
aimto synthesize evidence systematic reviews management urinary incontinence promotion continence using conservative behavioural approaches older people care homes inform clinical practice guidelines research backgroundincontinence highly prevalent older people care home populations designsystematic review systematic reviews narrative synthesis data sourceselectronic searches published systematic reviews english using medline cinahl date restrictions september searches supplemented hand searching electronic searching cochrane library prospero review methodsprisma statement followed established methods systematic review systematic reviews resultsfive systematic reviews high quality included three specific intervention studies two reviewed descriptive studies urinary incontinence primary outcome three reviews factors associated management urinary incontinence primary outcome reviews conclusiontoileting programmes particular prompted voiding use incontinence pads main conservative behavioural approach management incontinence promotion continence population evidence effectiveness short term evidence associated factors exercise mobility comorbidities hydration skin care staff perspectives policies older people experiences preference limited majority evidence effectiveness studies one country may may transferable care home populations future international studies warranted complex combined interventions using mixed methods provide evidence effectiveness context implementation economic evaluation
prospective week open label trial evaluates tolerability efficacy memantine hydrochloride treatment core social cognitive deficits adults high functioning autism spectrum disorder asd measures assessment therapeutic response included social responsiveness scale adult research version srs disorder specific clinical global impression scales behavior rating inventory executive functioning adult self report diagnostic analysis nonverbal accuracy scale cambridge neuropsychological test automated battery eighteen adults mean age years high functioning asd srs raw score treated memantine mean dose range completed trial treatment memantine associated significant reduction informant rated srs clinician rated clinical global impression improvement subscale measures autism severity addition memantine treatment associated significant improvement adhd anxiety symptom severity significant improvement noted nonverbal communication diagnostic analysis nonverbal accuracy scale test executive function per self report behavior rating inventory executive functioning adult self report global executive composite neuropsychological assessments cambridge neuropsychological test automated battery memantine treatment generally well tolerated associated serious adverse events treatment memantine appears beneficial treatment asd associated psychopathology cognitive dysfunction intellectually capable adults future placebo controlled trials warranted
creation high bond strength machined computer manufactured pure titanium porcelain remains problematic effects silica coating bond strength milled pure titanium bonded dental porcelain require investigation objective study evaluate bond strength machined pure titanium intermediate coating silica dental porcelain work specimens milled pure titanium prepared randomly divided test control groups test group coated silica using sol gel dipping technique metal ceramic bond strength evaluated according iso standards using three point bending test scanning electron microscopy energy dispersive spectroscopy used study microstructure elemental composition specimens bonding strength silica coated group significantly higher control group residual porcelain metal surface could observed silica coated group therefore application silica intermediate coating produced using sol gel method could significantly improve bond strength machined pure titanium porcelain
ovary contains oocytes within immature primordial follicles fixed number birth activation follicles within fixed pool causes irreversible decline reproductive capacity known ovarian reserve menopause premenopausal women undergoing commonly used genotoxic dna damaging chemotherapy experience accelerated loss ovarian reserve leading subfertility infertility therefore considerable interest little effective progress preserving ovarian function chemotherapy show blocking kinase mammalian mechanistic target rapamycin mtor clinically available small molecule inhibitors preserves ovarian function fertility chemotherapy using clinically relevant mouse model chemotherapy induced gonadotoxicity cyclophosphamide inhibition mtor complex mtorc clinically approved drug everolimus rad inhibition mtorc experimental drug ink show mtor inhibition preserves ovarian reserve primordial follicle counts serum anti mullerian hormone levels rigorous measure ovarian reserve fertility chemotherapy treated animals significantly fewer offspring compared treatment groups whereas cotreatment mtor inhibitors preserved normal fertility inhibition mtorc mtorc within ovaries achieved chemotherapy cotreatment concomitant preservation primordial follicle counts importantly findings indicate little two fourfold reduction mtor activity preserves ovarian function normal birth numbers everolimus approved tamoxifen resistant relapsing estrogen receptor positive breast cancer findings represent potentially effective readily accessible pharmacologic approach fertility preservation conventional chemotherapy
paper presents simple state space based method design realization variable band pass band stop iir digital filters proposed variable filters allow tune frequency characteristics also ensure high performance respect finite wordlength effects norm dynamic range scaling limit cycles roundoff noise coefficient sensitivity achieve property using gramian preserving frequency transformation implemented replacing delay element given prototype filter second order pass function four multiplier lattice structure shown proposed variable filters described rather simple form without need inverse matrix appeared conventional gramian preserving frequency transformation moreover show high performance proposed method comparison possible types frequency transformations implemented typical one multiplier two multiplier lattice forms direct form elsevier inc rights reserved
purpose review electronic cigarette cigarette use rapidly increasing many users reporting trying cigarettes method quit combustible cigarettes review highlights recently published studies assessing use cigarettes tool cessation combustible cigarettes recent findings evaluating data four randomized controlled trials multiple cohort studies differential association cigarette use cessation rates seen cessation rates highest cohort studies studies using multifaceted approach addition varenicline largest evidence base derived observational cohort studies overall current evidence remains small conclusive results regarding efficacy cigarettes combustible cessation appear consistent reduction daily combustible cigarette use regular cigarette users summary currently conflicting data used support dismiss cigarettes tool smoking cessation larger population based studies become available potential harms benefits cigarettes become clearer short term shared decision making combustible cigarette users imperative considering cigarettes smoking cessation tool
paper comprehensive review methods voltage sag source location presented also nine generalized methods using positive sequence phasors instantaneous positive sequence components clarke components integration introduced discussed methods use single criteria results show accuracy limited therefore paper proposes another novel method using robust support vector machine svm many features extracted based previously described methods source location machine learning technique discussed two steps detail svm linear polynomial radial basis function rbf kernels applied along optimal genetic search also fold cross validation used prevent fitting effect principal component analysis pca investigated comparative analysis performed existing methods nine generalized methods novel method applying extensive numerical simulations brazilian regional utility using pscad emtdc matlab finally effectiveness methods obtained reactive power based generalized methods using instantaneous positive sequence components clarke components gave right location total simulated cases whereas robust svm based method rbf kernel without pca highest accuracy elsevier rights reserved
spa speaking plant approach comparatively modern cultivation method grows plant according biological information spa plant factory system suitable elements use engineering education paper new education trial ktc kanazawa technical college private technical college japan graduate study spa plant factory system construction introduced system includes five significant educational elements engineers measurement analysis control circuits algorithms importance interdisciplinary education also present since system combines engineering agriculture study program consists five steps researching literature previous studies system algorithm design hardware software design system construction system operation program evaluated view point cdio student feedback study contents satisfy conceive design implement operate elements cdio students identified advantages type interdisciplinary program interest investigating study fields novelty combining life sciences engineering awareness trial error survey concluded trial effective engineering education
central topic discussion exploration semantic disturbance alzheimer disease concerns relative contribution semantic content semantic features semantic process studies suggested semantic dysfunction result deficits either semantic process semantic content studies supported loss semantic content criticised use verbal stimuli cognitively challenging experimental tasks current study used novel version yes recognition memory task compare processing distinctive non distinctive features participants whilst controlling cognitive demands task task involved five conditions denoted relationship items test study phase non distinctive distinctive condition included non distinctive distinctive semantic features manipulated study test respectively task accuracy participants decreased relative control participants distinctive features manipulated study test phase experiment significant difference groups non distinctive features manipulated findings provide evidence support loss semantic content elsevier ltd rights reserved
article introduces innovative pwm current mode technique control switched mode power supplies regulating output power supply proposed technique used control common offline power supply topologies control converter using new methodology possible greatly simplify internal architecture integrated controller reducing complexity costs greatly simplifying overall system design process
mature moral judgments include analysis outcomes others actions well mental states drive adults easily incorporate intention outcome moral evaluations scores developmental studies suggest may uniquely difficult young children privilege intention judgments right wrong piaget leading conclusion moral mind young child fundamentally different older children adults current studies utilize puppet choice methodology shown provoke reliable social preferences throughout first year birth hamlin wynn bloom provide evidence month old infants incorporate even privilege intentions social evaluations contrast month olds appear able distinguish characters intend outcomes cause results suggest one requirement mature moral judgments ability distinguish intentions outcomes morally relevant events present months age elsevier rights reserved
slope supported gabion geotextile bag high supporting strength local materials convenient construction adaptability environmental protection low noise low engineering cost advantages rapid development wide application achieve supporting retaining structure red beds slope effectively play role protection convenient construction reduce project cost conditions indoor model comparative analysis natural slope model without shoring model supported geotextile gabion carried obtain conclusion protective effect gabion better specific suggestions suitability construction supporting structure gabion put forward
background high dose biotin therapy beneficial progressive multiple sclerosis expected adopted large number patients biotin therapy leads analytical interference many immunoassays utilize streptavidin biotin capture techniques yielding skewed results mimic various endocrine disorders aimed exploring interference able remove biotin avoid misleading results methods measured free triiodothyronine free thyroxine thyroid stimulating hormone tsh parathyroid homrone pth hydroxyvitamin ohd follicle stimulating hormone fsh luteinizing hormone prolactin peptide cortisol roche diagnostics assays biotin main metabolites liquid chromatography tandem mass spectrometry plasmas patients healthy volunteers receiving high dose biotin biotin unsupplemented patients simple procedure designated designed remove biotin means streptavidincoated microparticles also assayed tsh pth high biotin plasmas using assays employing streptavidin biotin binding results biotin concentration ranged high biotin plasmas samples protocol biotin concentration detection limit two samples hormones results abnormal normalized results alternative methods normal except two slight pth elevations biotinunsupplemented patients protocol affect results hormones apart decrease pth conclusions confirm streptavidin biotin hormone immunoassays affected high biotin concentrations leading risk misdiagnosis simple neutralization method efficiently suppresses biotin interference
background corticotropin releasing factor crf signaling crf receptor crfr ventral tegmental area vta modulate ethanol consumption rodents however effects binge like ethanol drinking system thoroughly characterized little known role crfr crf neurocircuitry involved methods effects binge like ethanol consumption vta crf system assessed following drinking dark procedures intra vta infusions selective crfr crfr compounds employed assess contributions receptors modulating binge like ethanol consumption determine potential role crf projections bed nucleus stria terminalis bnst vta crf neurons circuit chemogenetically inhibited binge induced changes vta crf system protein messenger rna also assessed results intra vta antagonism crfr activation crfr resulted decreased ethanol intake eliminated simultaneous blockade receptors chemogenetic inhibition local crf neurons vta alter binge like ethanol drinking inhibition vta projecting crf neurons bnst significantly reduced intake conclusions provide novel evidence blunted binge like ethanol consumption stemming crfr blockade requires intact crfr signaling crfr activation reduces binge like drinking inhibiting vta projecting bnst crf neurons attenuates binge like drinking binge like ethanol drinking alters protein messenger rna associated vta crf system data suggest ethanol induced activation bnst vta crf projections critical driving binge like ethanol intake
plethora multi agent systems mas development methodologies exists compete prominence paper advocates unification best breed activities methodologies examines two existing approaches unifying access proposes alternative approach focusses use domain knowledge ontologies offering best potential unifying access reliance ontologies provide flexibility process workproducts use within methodology focus domain knowledge reduce number mandatory methodological tasks time create scope reuse respect system designs components paper sketch argue full software development lifecycle mas ontologies expressing domain knowledge central artifacts
article review intelligent robotic algorithm approaches propose novel neural network based approach nonlinear systems nonlinear systems represented nonlinear tagaki sugeno models linear differential inclusion state space representation utilized deal controlled systems stability conditions controller design representation derived based fuzzy parallel distributed compensation scheme employed construct global fuzzy logic controller blending local state feedback controllers time delay states exist nonlinear simulated example including chaotic disturbances given show feasibility proposed fuzzy controller design approach
parametric convex programming received lot attention since many applications chemical engineering control engineering signal processing etc inverse optimality plays important role many contexts image processing motion planning paper introduces constructive solution inverse optimality problem class continuous piecewise affine functions main idea based convex lifting concept accordingly algorithm construct convex liftings given convexly liftable partition put forward following idea important result presented article continuous piecewise affine function defined polytopic partition solution parametric linear quadratic programming problem regarding linear optimal control shown continuous piecewise affine control law obtained via linear optimal control problem control horizon equal prediction steps
objectives october evidence needed make recommendation use electronic nicotine delivery systems ends smoking cessation limited used arkansas behavioral risk factor surveillance system additional state specific questions determine prevalence ends use impact ends use smoking cessation beliefs ends use arkansas objectives determine ends use associated lower odds quitting smoking ends users believed ends use harmful health ends users believed switching ends reduced tobacco related health risks methods conducted cross sectional study respondents arkansas behavioral risk factor surveillance system used weighted analyses account complex survey design used subset records formed formers smokers quitted smoking last years current smokers assess odds quitting results confidence interval arkansas adults currently using ends participants current smokers quit smoking within past years used ends ends users continued smoking ends use significantly associated reduced odds quitting smoking weighted odds ratio although participants believed harmful nonsmokers start using ends participants believed switching ends reduce tobacco related health risks ends users shared respective beliefs conclusions smokers indicated smoking past years tried ends stop smoking ends use inversely associated smoking cessation tobacco cessation programs tell cigarette smokers ends use may help quit smoking
antiphospholipid syndrome aps autoimmune disease characterized venous thromboembolism arterial thrombosis obstetric morbidities setting persistently positive levels antiphospholipid antibodies measured different occasions weeks apart patients aps increased risk accelerated atherosclerosis myocardial infarction stroke valvular heart disease vascular endothelial cell dysfunction mediated antiphospholipid antibodies subsequent complement system activation play cardinal role aps pathogenesis improved understanding pathogenic function could help risk stratification patients aps provide new molecular therapeutic targets american college cardiology foundation
purposes study develop simulator generating ski board vibration actual skiing perform basic construction clarifying ski sliding mechanism still clarified completely simulator developed study surface bottom ski assumed snowy slope mass snow snow pack assuming skier slid ski bottom surface ball vibrator connected large sized compressor installed onto ski panel order vibrate ski board compressed air compressor rotated steel ball vibrator high speed causing vibration ski dynamic friction force detected digital force gauge snow pack sliding top ski tail surface formed bottom ski coefficient kinetic friction calculated using dynamic friction force furthermore velocity acceleration snow pack measured two high speeded cameras experiment confirming validity simulator carried temperature conditions degrees velocity acceleration snow pack vibration higher without vibration hand coefficient kinetic friction vibration lower without vibration results simulator suitable studying role vibration ski sliding clarifying ski sliding mechanism authors published elsevier ltd selection peer review responsibility school aerospace mechanical manufacturing engineering rmit university
patients borderline personality disorder bpd often engage non suicidal self injury nssi reduce arousal levels stress however importance seeing blood effect nssi yet unknown present pilot study examined female bpd patients healthy controls assess role seeing blood arousal pain urge nssi ratings heart rate continuously measured participants completed two sessions consisting stress induction forced mental arithmetics white noise followed seven second non invasive pain stimulus blade volar forearm one session painful blade stimulus applied artificial blood added arousal significantly stronger decrease revealed bpd group however significant effects blood non blood conditions concerning urge nssi bpd showed significantly greater decrease blood condition time group interestingly heart rate decreased stronger time group blood condition bpd tension relief non damaging mechanical painful stimulus addition visible blood showed neither subjective arousal urge nssi objective heart rate advantages
connexins cxs integral membrane proteins form high conductance plasma membrane channels allowing communication cell cell via gap junctions cells extracellular environment via hemichannels initially described role joining excitable cells nerve muscle gap junctions gjs found virtually cells solid tissues essential functional coordination enabling direct transfer small signalling molecules metabolites ions electrical signals cell cell several studies revealed diverse channel independent functions cxs include control cell growth tumourigenicity connexin widespread human body myriad roles implication development disorders cancer inflammation osteoarthritis alzheimer disease given rise many novel questions several rna dna binding motifs predicted sequences using different computational methods review provides insights new groundbreaking functions cxs highlighting important areas future work transfer genetic information extracellular vesicles discuss implication potential rna dna binding domains sequences cellular communication control signalling pathways author
gray water recycling economical use rainwater valuable alternative source water especially non potable uses sources seen basis change waters management gives possibility protection still shrinking water resources taking account continuing urbanization population growth world management water resources requires change attitudes also management conservation conventional fuels energy generated required development functioning urban areas bearing mind studies performed order establish cost effectiveness application systems capable reducing demand tap water electricity used heat financial analysis application life cycle cost methodology conducted multi family residential building seven different variants installation water sewage assumed use following solutions gray water harvesting system rainwater harvesting system drain water heat recovery units analysis showed use systems tested building financially viable despite fact implementation associated incurring higher investment cost base case variant study expanded sensitivity analysis basis possible conclude project involving use alternative sources pending water energy building slightly susceptible changes calculation parameters elsevier rights reserved
children often need help parents ready stop fighting children center high conflict disputes particularly resist contact parent face extraordinary risks maladjustment years investigation litigation may precede meaningful attempt intervention based questionable belief elements causality blame must established effective treatment occur children functioning may continue deteriorate time undermining future adjustment reducing chance successful intervention later illustrate application coping focused multisystemic child centered conjoint therapy model assisting families methods assist children without compromising external investigations discussed
podocytes crucial preventing passage albumin urine lost associated development albuminuria renal failure cardiovascular disease podocytes limited capacity regenerate therefore pro survival mechanisms critically important insulin like growth factor igf potent survival growth factor however major function thought prenatal development circulating levels high igf previously reported continue expressed discrete regions brain adulthood rodents systemic levels undetectable using conditionally immortalized human vivo adult mouse cells glomerulus demonstrated podocyte major glomerular source target igf signals cell via igf receptor via kinase mapk pathways functionally reduction igf signalling causes podocyte cell death vitro glomerular disease vivo aged igf transgenic mouse produces approximately igf due lack promoter gene collectively work reveals fundamental importance igf mature podocyte glomerular health across mammalian species copyright pathological society great britain ireland published john wiley sons ltd
novel material electrochemical determination endocrine disruptors using composite based graphene oxide modified cadmium telluride quantum dots evaluated morphology structure electrochemical performance composite electrodes characterised transmission electron microscopy dynamic light scattering visible absorption spectra fluorescence spectra raman spectra cyclic voltammetry dynamic light scattering transmission electronic microscopy spectrophotometric measurements showed good distribution quantum dots small particle size electrochemical measurements demonstrated high performance composite response presence light source differential pulse voltammetry allowed development method determine estradiol levels range moll detection limit nmoll
laser induced change refractive index fullerene nanotubes doped conjugated structures investigated dynamic holographic technique nonlinear refractive index nonlinear optical susceptibility chi compounds calculated role high frequency kerr photorefractive effect holographic grating recording nanosecond laser irradiation discussed niche organic materials doped nano objects found among nonlinear optical systems nano object stimulated improvement laser strength materials shown
article reviews evaluation studies programs designed treat sex offenders intellectual developmental disabilities idd published peer reviewed journals design study mirrored prisma preferred reporting items systematic reviews meta analyses recommendations conducting systematic literature review study design study setting characteristics participants type treatment intervention procedures comprise areas focus evaluating implementation treatment programs therapeutic outcomes include changes attitudes consistent sex offending victim empathy sexual knowledge cognitive distortions problem sexual behaviors eighteen treatment evaluation studies identified united states united kingdom australia new zealand cognitive behavioral treatments commonly delivered treatment modality sex offenders idd less common treatments dialectical behavioral therapy problem solving therapy mindfulness relapse prevention randomized controlled trials identified common designs multiple case studies pre post treatment assessments control repeated measures follow small sample sizes control groups wide variation treatment length follow time complicate qualitative synthesis study findings short follow times introduce potential bias conclusions surrounding treatment efficacy many studies reviewed analysis overall quality studies examining treatments sex offenders idd poor requires development rendering firm conclusions effectiveness interventions population
two vignette studies conducted preadolescent children study study aged years evaluated exclusion unknown reasons immigrant minority child native majority peer majority interethnic exclusion study compared children evaluations majority interethnic exclusion evaluations majority minority intraethnic exclusion minority interethnic exclusion study examined children underlying explanations study compared ethnic majority ethnic minority respondents examined role group bias former overall ethnic majority ethnic minority respondents regarded majority interethnic exclusion negatively exclusion types majority intraethnic minority interethnic minority intraethnic children especially older minority respondents likely reject majority interethnic exclusion perceived discriminatory ethnicity based among majority children strong group bias associated weaker condemnation majority interethnic exclusion due larger tolerance ethnicity based discrimination biased majority children also less likely reject minority intraethnic exclusion indicating overall weaker concern group victims taken together studies show children relatively negative majority prototypical interethnic exclusion implies possibility ethnic discrimination concur previous evidence developmental increase awareness discrimination ethnic minority youths elsevier inc rights reserved
objectives estimate relationship hiv natural history fertility duration infection east southern africa availability antiretroviral therapy assess potential biases estimates age specific subfertility using retrospective birth histories cross sectional studies design pooled analysis prospective population based hiv cohort studies masaka uganda kisesa tanzania manicaland zimbabwe methods women aged years ever tested hiv included analyses censored antiretroviral treatment roll fertility rate ratios calculated see relationship duration hiv infection fertility adjusting background characteristics survivorship misclassification biases age specific subfertility estimates cross sectional surveys estimated reclassifying person time cohort data simulate cross sectional surveys comparing fertility rate ratios true cohort results results hiv negative hiv positive women contributed births person years births person years respectively final dataset adjusting age study site calendar year additional year since hiv seroconversion associated confidence interval relative decrease fertility hiv positive women survivorship misclassification biases simulated retrospective birth histories resulted modest underestimates subfertility age groups years conclusion longer duration infection associated greater relative fertility reduction hiv positive women considered creating estimates hiv prevalence among pregnant women prevention mother child transmission need course hiv epidemic antiretroviral treatment scale copyright wolters kluwer health inc rights reserved
following introduction general medical council regulations handling poor medical performance interview survey study carried among senior health professionals national health service nhs aims study explore respondents perceptions poor medical performance seek experience handling poorly performing doctors sixteen interviews held face face followed telephone interviews subsequently using similar questions interview schedule survey carried among senior health professionals across nhs interview results identified number barriers resolving poor performance unwillingness doctors seek advice protective culture prevented complaints made doctors survey respondents high standards judged poor performance hesitant considering poor consultation skills significance poor technical skills however problems communication skills frequently reported type poor performance new arrangements handling nhs doctors whose performance perceived poor much overcome barriers effective action expressed respondents study
parkinson disease patients show marked impairments processing action verbs lesser extent concrete specially manipulable nouns however still unclear extent deficits categories influenced general cognitive dysfunctions whether modulated words implied motility examine issues evaluated non demented patients healthy volunteers oral production task patients divided two groups depending presence absence mild cognitive impairment mci nmci respectively participants named pictures actions varying motion content low high objects varying manipulability low high mci group showed deficits across four categories however nmci patients exhibited selective difficulty high motion action verbs finding corroborates refines previous results suggesting disturbances action related lexico semantic information constitute sui generis alteration manifested early course disease physiopathology moreover suggests grounding action verbs motor circuits could depend finegrained intracategorical semantic distinctions elsevier inc rights reserved
remote sensing algorithms often invert multiple measurements simultaneously retrieve group geophysical parameters order create robust retrieval algorithm necessary ensure unique measurements parameters retrieved case inversion might multiple solutions sensitive noise letter introduce methodology calculate number possibly fractional degrees information set measurements representing number parameters retrieved robustly set since different measurements may mutually independent amount duplicate information calculated using information theoretic concept total correlation generalization mutual information total correlation sensitive full distribution measurement therefore accounts duplicate information even multiple measurements related partially nonlinearly method illustrated using several examples applications variety sensor types discussed
cvd remain leading cause death globally effective dietary strategies reduction high priority increasing evidence suggests phytochemicals particularly dietary flavonoids nitrates key modulators cvd risk reduction impact multiple risk factors aim review explore evidence impact flavonoid nitrate rich foods supplements cvd risk specific reference importance mediators vascular health platelet function accumulating evidence support benefits dietary flavonoids cardiovascular health dose dependent recovery endothelial function lowering blood pressure reported flavanol epicatechin found cocoa apples tea production availability endothelial nitric oxide furthermore flavonoids including quercetin metabolites reduce vitro vivo platelet function via inhibition phosphorylation dependent cellular signalling pathways although vivo studies required substantiate mechanistic effects hypotensive effects dietary nitrates consistently reported healthy subjects acute chronic settings although less evidence effects patient groups proposed mechanisms actions include endothelial independent availability dependent entro salivary circulation microbial conversion dietary nitrate nitrite mouth conclusion flavonoid nitrate rich foods show promising effects vascular function yet randomly controlled studies required confirm findings determine effective doses
study aims investigating structural behavior fatih sultan mehmet suspension bridge second bosphorus bridge turkey multi point earthquake excitations determining earthquake performance bridge based results obtained analysis objective spatially varying ground motions triple direction produced support bridge considering scenario earthquakes main marmara fault order simulate ground motions modified stochastic finite fault technique utilized taking ground motions account non linear time history analysis carried results obtained analysis compared uniform support earthquake excitation identify effects multi point earthquake excitations seismic performance bridge analysis determined modal response towers deck mostly effective dynamic response entire bridge rather structural elements cable approach viaduct compared results obtained simple point earthquake excitation noticeable axial force increase cable elements obtained multi point earthquake excitation changes main cable side span cable determined respectively much increase cable elements led increase axial force towers shear force base section tower column changes structural elements closely related response deck towers since considerable contribution response entire bridge based findings study spatially varying ground motions considered long span suspension bridges multi support earthquake analysis carried better understanding obtaining reliable results necessary retrofitting performance evaluation elsevier ltd rights reserved
background shortage nurses working mental health field globally aim present study examine singapore nursing students attitudes towards specializing psychiatric nursing examining pre nursing nursing school factors well attitudes towards psychiatry personality traits methods cross sectional online survey conducted nursing students four nursing institutions singapore students attitudes towards psychiatry atp perception psychiatric nursing career aspects relative fields personality traits mini ipip assessed main outcome measure likelihood specializing psychiatric nursing logistic regression used examine combined effect factors upon outcome results twenty six students rated definitely decided psychiatric nursing pre nursing school factors associated choosing psychiatry included ethnicity current education parents wishes personal family experience mental illness prior work experience interest psychiatric nursing psychology module taken prior current school admission nursing school factors teaching methods clinical exposure associated choosing psychiatric nursing positive attitudes towards psychiatry perception better career aspects psychiatric nursing relative fields personality traits extraversion intellect imagination associated likelihood choosing psychiatric nursing logistic regression revealed malay indian ethnicity interest psychiatry psychology module prior current school admission better perceived job prospects psychiatric nursing fields extraversion positive attitude towards psychiatry factors associated students choosing psychiatric nursing conclusions selection psychiatry specialty nursing students affected pre nursing school factors taking factors consideration may improve recruitment alleviate shortages psychiatric nursing field authors published elsevier ltd
propose explore applicability file timestamps steganographic channel identify information gap storage usage timestamps modern operating systems use high precision timers building describe layered design steganographic system offers stealthiness robustness wide applicability proposed design evaluated theoretical evidence based experimental analysis case ntfs using datasets comprising millions files report proof concept implementation confirm embedded information indistinguishable normal filesystem use finally discuss digital forensics analysis implications new information hiding technique author published elsevier ltd
bariatric surgery increased popularity roux gastric bypass rygb one frequently performed leads many cases stomach removed routine gastroscopy access sometimes major source concern performing enteroscopy patients technically difficult present experience cases aim access detached stomach retrospective analysis rygb enteroscopy procedures aimed access detached stomach data recorded demographic parameters indication gas insufflation time bypass stomach total procedure recovery times endoscopic pathological findings study included patients underwent rygb previous months indications chronic abdominal pain refractory anemia unexplainable weight loss detached stomach accessed patients access time ranged min recovery time procedures min average shorter insufflation min detached stomachs showed macroscopic gastritis four helicobacter pylori positive significant findings included three patients jejunojejunostomy stenosis one patient marginal gastrojejunal ulcer later diagnosed signet ring cell carcinoma proximal anastomosis present feasibility importance enteroscopy detached stomach believe procedure performed frequently high index suspicion needed postoperative symptoms order exclude significant pathologies reassure symptomatic patients abnormality bypassed stomach
human interferon gamma cytokine belonging diverse group interferons crucial immunological function mycobacteria wide variety viral infections date approved treatment chronic granulomatous disease malignant osteopetrosis application immunotherapeutic agent cancer increasing prospect recombinant human interferon gamma lucrative biopharmaceutical engineered different expression systems including prokaryotic protozoan fungal yeasts plant insect mammalian cells human interferon gamma commonly expressed escherichia coli marketed actimmune however resulting product prokaryotic expression system unglycosylated short half life bloodstream purification process tedious makes product costlier expression systems also show satisfactory results terms yields biological activity protein economic viability thus review aims synthesise available information previous studies production human interferon gamma glycosylation patterns different expression systems provide direction future research field elsevier rights reserved
article presents description cloud based elearning platform capable support implementation called body syntonic reasoning summarizes research proposal put together number players field learning architecture result research initiative started recently bucharest university economic studies aim initiative create state art elearning platform used teaching computer programming children students using elements body syntonic reasoning elearning platform article also invitation addressed interested researchers join research initiative
smokeless tobacco use among high school males living rural areas exceeds national levels subgroups heightened risk use identified less known regarding decision making within high risk groups study objective describe rural adolescent males perceived acceptability health risks social implications perceptions differ users never users semi structured individual interviews conducted purposeful sample male students ever users three rural california high schools interviews audio recorded professionally transcribed investigators collaboratively developed codebook based thematic content independently coded transcripts reconvening frequently achieve consensus coded text systematically organized themes following general inductive approach users non users shared multiple related perceptions including common normative way life rural country culture among certain groups use conveys oral health risks decision use use rooted personal choice users never users perceptions differed regarding immediacy severity inevitability health risks particularly relative cigarette smoking differences included perceived parental permissiveness expected social benefits use peer acceptance conveying maturity within population rural male adolescents users emphasized social benefits use acknowledging discounting health risks differences similarities tobacco perceptions among adolescents living similar environments may inform effective health communication
order improve performance hydraulic support electro hydraulic control system test platform self tuning proportion integration differentiation pid controller proposed imitate actual pressure hydraulic support avoid premature convergence improve convergence velocity tuning pid parameters pid controller optimized hybrid optimization algorithm integrated particle swarm algorithm pso genetic algorithm selection probability adaptive cross probability introduced pso enhance diversity particles proportional overflow valve installed control pressure pillar cylinder data control voltage proportional relief valve amplifier pillar pressure collected acquire system transfer function several simulations different methods performed hydraulic cylinder pressure system results demonstrate hybrid algorithm pid controller comparatively better global search ability faster convergence velocity pressure control hydraulic cylinder finally experiment conducted verify validity proposed method
objectivesto examine factors associated isolation precaution use nursing home residents multidrug resistant organism mdro infection designretrospective cross sectional analysis settingnursing homes centers medicare medicaid services certification october december participantselderly long stay residents positive mdro infection assessments measurementsdata obtained minimum data set mds certification survey provider enhanced reporting area health resource file multivariable regression facility fixed effects conducted resultsthe sample included assessments residents mdro infection isolation use recorded nhs reporting mdro infection past year used isolation least among residents mdro infection resident characteristics positively associated isolation use included locomotion eating support isolation use lower mdro history residents nhs received infection control related citation past year greater probability isolation use nhs received quality care citation lower probability isolation use conclusionthis first study examine new mds isolation mdro items isolation infrequently used proportion isolated mdro infections varied facilities inspection citations related isolation use following year research needed determine whether isolation used best decrease risk mdro transmission improve quality care
recent years multimorbidity rheumatic conditions gained increasing attention rheumatologist care aging patient population multiple diseases therefore multimorbidity rule exception owing high prevalence potential interaction coexisting diseases multimorbidity needs taken account treating patients chronic inflammatory conditions review address prevalent comorbidities patients rheumatic conditions impact important outcomes physical function quality life mortality
paper propose new stochastic approach automatic detection network structures raster data represent network set trees acyclic planar graphs embed model probabilistic framework spatial point processes determine probable configuration trees stochastic sampling different configurations constructed randomly modifying graph parameters adding removing nodes edges tot current trees configuration evaluated based probabilities changes energy function describing conformity predefined model using reversible jump markov chain monte carlo sampler approximation global optimum energy function iteratively reached although main target application extraction rivers tidal channels digital terrain models experiments types networks images show transferability applications qualitative quantitative evaluations demonstrate competitiveness approach respect existing algorithms international society photogrammetry remote sensing inc isprs published elsevier rights reserved
purpose review cardiovascular disease cvd responsible morbidity mortality worldwide ailment strategies reducing cvd prevalence must involve identification individuals high risk diseases prevention initial development preventive efforts currently limited incomplete understanding genetic determinants cvd risk review evidence involvement inherited mitochondrial mutations development cvd examined recent findings several forms cvd documented presence pathogenic mitochondrial dna mtdna mutations isolation part larger syndromes natural mtdna polymorphisms overtly tied pathology also associated alterations mitochondrial function individual risk cvd recently studies merely correlative fortunately novel animal models allowing investigators define causal relationship inherited natural mtdna polymorphisms cardiovascular function pathology summary cardiovascular involvement highly prevalent among patients pathogenic mtdna mutations relationship cvd susceptibility natural mtdna polymorphisms requires investigation aided near future several novel experimental models
due requirement two operational modes washing spinning modes washing machine design motor meet required torque efficiency mode easy task achieve requirements pole outer rotor type switched reluctance motors orsrm proposed choose suitable design parameters washing machine static toque srm compared based fem analysis selected motor obtained high wide toque types motor pole shape arc optimized get higher torque lower torque ripple verify proposed structure prototype manufactured finally simulation experiment results verify validity proposed structure
stresses deflections developed due piping loads produce significant deformation nozzles pressure vessels paper spherical pressure vessel two cylindrical nozzles analyzed stresses nozzles evaluated using two comparative methods one represents classical way using superposition axial bending torsional loads one based requirements asme boiler pressure vessel cod section viii division developed analysis order obtain loads forces moments end nozzle specialized finite element program used program coade caesar allows studying strength flexibility behavior pipes connect analyzed nozzle rest plant results obtained compared order find using classical methods strength materials used conservative approaches finite element method applied order check important load cases appear interaction pipes shell respect sustained proper gravity loads expansion thermal loads occasional wind seismic loads combined order check requirements asme study contains also effect pressure trust influence real geometry junction nozzle shell peaks stresses
asthma rhinitis eczema complex diseases multiple genetic environmental factors interlinked igeassociated non ige associated mechanisms mechanisms development allergy medall project studied complex links allergic diseases clinical mechanistic levels linking epidemiologic clinical mechanistic research including vivo vitro models medall integrated european birth cohorts including participants cohort follow ups pregnancy age years thirteen thousand children prospectively followed puberty using newly standardized medall core questionnaire microarray developed allergen molecules increased ige sensitivity obtained children estimates air pollution exposure previous studies available children omics data included historical genome wide association studies children dna methylation targeted multiplex biomarker transcriptomic studies using classical epidemiology machine learning methods children aged years children aged years medall showed multimorbidity eczema rhinitis asthma estimated multimorbidity attributable ige sensitization medall proposed new vision multimorbidity independent ige sensitization shown monosensitization polysensitization represent distinct phenotypes translational component medall shown identification novel allergic phenotype characterized polysensitization multimorbidity associated frequency persistence severity allergic symptoms results medall help integrate personalized predictive preventative participatory approaches allergic diseases
describe complete fast implementation compute discrete cosine transform briefly discuss hardware model developing toolkit employ array common processors handling data level words automatic data flow synchronization present general software solution opposed custom built hardware description solution unique composition two algorithms yielding systolic highly parallel regular data flow implementation efficient utilization resources high although solution computationally intensive suitable real time applications input data infinite sequence matrices input one row time continuously finally discuss programming tools needed ease programming effort hope work demonstrates importance tools
research shows need develop psychosocial interventions specifically young people intellectual developmental disabilities idd families optimize mental health present pilot study week mindfulness based group conducted eight adolescents idd parents qualitative evidence suggests may benefits joint groups youth parents parents youth enjoyed group gained insight trend observed youth participants self reported mood improved following session social behaviours reported parents improve well challenges encountered however despite parents involvement group participants reported resistant practicing mindfulness skills outside sessions study expands therapeutic modalities available youth idd families showing min mindfulness based intervention may help youth idd learn manage emotions within
background several studies show association eczema attention deficit hyperactivity disorder adhd childhood mechanisms time sequence remain unclear information association eczema disorders involving central nervous system cns limited aim explore whether preschool eczema associated adhd cns associated disorders requiring pharmacotherapy school age analyze whether eczema ages childhood associated medication adhd methods swedish birth cohort children included analyses years age parents answered questionnaires regarding eczema last year information prescribed medications school age years age derived record linkage swedish prescribed drug register results total children preschool eczema eczema years children dispensed adhd medication school age preschool eczema associated adhd medication school age crude odds ratio confidence intervals significant association preschool eczema use antidepressants migraine drugs anti epileptics school age infantile eczema school age eczema eczema ever years age associated adhd medication school age conclusions large birth cohort significant associations preschool eczema medications adhd depression anxiety phobia migraine epilepsy school age
sudden changes loading configuration electrical network causes power swing may result unwanted tripping distance relay hence becomes utmost necessary rapidly reliably discriminate actual fault power swing conditions order prevent instability power network due mal operation distance relay paper proposes novel method discrimination fault power swing based rate change voltage reactive power measured relay location effectiveness proposed algorithm evaluated simulating series power swing conditions pscad emtdc software different disturbances change mechanical power input synchronous generator tripping parallel line due fault sudden application heavy load revealed distance relay gives successful tripping case different fault conditions remains inoperative power swing implementation proposed algorithm moreover proposed scheme ability distinguish symmetrical asymmetrical fault occurrence power swing condition
purpose sought understand variations expression temporal relation bladder control episodes among women mixed urinary incontinence materials methods random sample women years old older mixed urinary incontinence globe general longitudinal overactive bladder evaluation urinary incontinence recruited digital daily diary study using smartphone application bladder control event occurred women instructed answer episode specific questions episodes defined urgency urinary incontinence urinary incontinence without urgency women episodes compared type activity preceding episode urinary incontinence episodes defined stress urinary incontinence urgency urinary incontinence stress induced urgency urinary incontinence chi square wilcoxon tests used categorical continuous variables respectively results women mean age years provided complete day diary data bladder control episodes reported urgency urinary incontinence urgency urinary incontinence without urgency urinary incontinence episodes without urgency occurred stress activity coughing sneezing notably stress activity also occurred urgency urinary incontinence episodes total women reported least episode stress induced urgency urinary incontinence prevalent urinary incontinence subtype episode followed urgency urinary incontinence stress urinary incontinence respectively mean number daily episodes across groups conclusions women mixed urinary incontinence express heterogeneous set bladder control episodes stress induced urgency urinary incontinence dominant type
decomposing divisor suitable factor basis jacobian hyperelliptic curve crucial step index calculus algorithm discrete log problem jacobian small genus curves year gaudry proposed suitable factor basis decomposition method work provide new method decomposition factor basis advantage new method admits sieving technique removes smoothness checking polynomials required gaudry method also total number additions jacobian required new method less required gaudry method new method quite simple present example decompositions timing results implementation method using magma
evidence research humans animals suggest ingesting alcohol pregnancy disrupt fetal immune system result increased risk infections disease newborns may persist throughout life alcohol may indirect effects immune system increasing risk premature birth risk factor immune related problems animal studies suggest alcohol exposure directly disrupts developing immune system comprehensive knowledge mechanisms underlying alcohol effects developing immune system become clear researchers establish improved methods identifying newborns exposed alcohol utero
parent interviews regard children accidents accident protective measures health interview examination survey children adolescents kiggs aimed extending knowledge age gender specific injuries identify risk groups risk factors injury prevention parents children aged years asked children injuries within last months medically treated accident mechanisms consequences injuries ambulatory hospital treatment addition parents children aged years asked give information protective measures according parents children least one injury within last months accident assault age group boys injured significantly often girls overall injured children adolescents hospitalized two thirds accidents among toddlers domestic accidents whereas leisure sport accidents prevalent children adolescents aged years years proportion accidents child care facilities educational institutions tripled infancy school age age years traffic accidents three frequent injury mechanisms age range years falls level ground falls heights collisions objects persons falls heights showed highest risk toddlers contusions sprains strains increased highest level adolescents likewise bone fractures increased toddlers adolescents aged years influence socioeconomic status injuries overall consequences injuries seen traffic accidents children aged years boys girls families lower socioeconomic status showed higher rates accidents children families higher socioeconomic status application protective measures lowest age group years according parents children aged years wear helmet riding bicycle skating quote lower age group dropped age group also rate using protective clothes lowest age group boys girls children adolescents rate self reported helmet use lower estimated parents age groups migration background low socioeconomic status associated lower use protective measures helmets protective clothes age related data analysis starting point prevention measures specific risk groups considering migration socioeconomic status prevention activities traffic focus families low social status adolescents specifically adequately addressed regarding benefits certain safety measures riding bicycle skating
article presents current review risk physical psychological injury associated participation elite youth sport suggests strategies ensure physical emotional health young athletes although lack epidemiological data especially regard psychological injury preliminary data suggest risk injury high population lack incident follow data also concern regarding burnout disordered eating long term consequences injury modifiable injury risk factors identified include postural control competition anxiety life events previous injury volume training presently studies designed determine effectiveness injury prevention measures elite youth sports however adequate evidence arising injury prevention studies youth sports participants including neuromuscular training protective equipment mental training enhance self esteem sport rules modification prevent injuries elite youth sports settings although tested psychosocial prevention strategies adoption task oriented coping mechanisms autonomous support parents proactive organizational approach also show promise injury prevention
study solutions one dimensional problem green lindsay lord shulman theories two temperatures first existence uniqueness weakly regular solutions obtained second prove exponential stability green lindsay model non exponential stability lord shulman model elsevier ltd rights reserved
context increasing human populations urban areas pose threat species persistence habitat loss fragmentation therefore essential develop methods investigate critical habitat loss thresholds least detrimental landscape configurations objectives develop framework assess pattern habitat loss impacts ecological social characteristics landscape varies depending species criteria judged methods use scenario based approach test six propositions habitat lost preferentially based patch characteristics use eight bird two amphibian species indicator species compare scenarios present method combining output metapopulation model measures social impacts land cover change multiple criteria decision analysis also determine whether habitat loss threshold exists small loss habitat lead large loss species occupancy results found scenarios presented preferentially losing common habitats smaller patches least detrimental ecological social factors threshold effects found generalist bird species conclusions outlined workflow allows transparent repeatable comparison landscapes workflow used compare urban landscape plans develop general understanding impacts different forms habitat loss reassuringly recommendations based scenarios presented keeping received conservation wisdom prioritise larger rarer patches
four dimensional building information modelling widely viewed next evolutionary step construction scheduling linking scheduling information parametric object models believed assist intuitive understanding built explore bim new method visualization compares pre existing forms visualization like bar flowline charts based series individual focus group interviews paper reports construction professionals perceptions utility different visualization methods simultaneously exposed three types scheduling building construction professionals evaluated ease use usefulness done based technology acceptance model explains individuals develop intention use technology based work found three scheduling methods strengths weaknesses gantt provides simplicity responsiveness required day day communication projects perceived easiest use flowline perceived less intuitive however argued provides better overview many different work activities need run concurrently bim clarity required conveying bigger picture yet perceived useful early project stages contribution body literature compare technology acceptance new existing scheduling methods order unearth complementary roles work important managers deciding combination planning tools enabling better run projects authors published elsevier ltd
original low power low voltage multifunctional structure improved precision presented performing many important circuit functions signal amplifying voltage multiplying squaring square rooting operations great advantages increased modularity controllability represent immediate consequence circuit multifunctionality accuracy circuit strongly increased implementing original techniques silicon occupied area per function reduced core used realizing proposed functions
perinatal smoking associated wide range negative reproductive pregnancy outcomes aim current study examine prevalence characteristics women report smoking prenatally quit pregnancy large sample romanian women understanding women likely quit contribute public health knowledge help women stop smoking prior pregnancy prevent relapse postpartum cross sectional analysis conducted based cross sectional data collected may april part cohort study pregnancy implemented six clinical settings central romania approximately sample reported smoking months prior learning pregnant half women reported smoking months learning pregnancy also reported stopped smoking time interview overall tobacco consumption decreased sample mode cigarettes day range pregnancy sample mode cigarettes day range time interview women quit higher socioeconomic position likely live urban areas partnered primigravid nulliparous reported lower anxiety social support combination socioeconomic gradient less anxiety social support suggests efforts increased target lower income less educated multigravid multiparous women develop programs heighten social support alleviate anxiety
reduce energy consumption pollution caused construction urgent renew building concept firstly connotation green building concept systematically analyzed secondly pointed establishing green building concept meets needs reducing costs improving quality users satisfaction lean flexible construction put forward scientific way establish carry green building concept considered lean flexible construction promote effectively application green building concept four aspects
visual cryptography variant form secret sharing general threshold setting allows set participants recover reconstruct secret stacking shares recently notion multiple secret introduced embed multiple secrets region incrementing visual cryptography rivc referred new type multi secret rivc defines layers takes secrets embeds secret layer layers defined number participants example let two secrets two layers two three rivc two participants recover three recover however another multi secret called fully incrementing visual cryptography fivc also layers one secret reveal one layer paper stating point propose new notion non monotonic visual cryptography nvc human vision system primitive construct fivc first present ideal construction simple nvc relies slightly unreasonable assumption based simple nvc show methods extend functionality complicated cases nvc generic construction presented systematic manner eliminate mentioned assumption finally formally introduce transformation nvc fivc algorithm takes nvc input produce construction fivc also show demonstration nvc rivc algorithm analyze properties regarding nvc believe notion nvc potentially find applications independent interest
cluster analysis aims classifying objects categories basis similarity widely used many areas pattern recognition image processing paper propose novel clustering algorithm called qcc mainly based following ideas density cluster center highest nearest neighborhood reverse nearest neighborhood clusters divided sparse regions besides define novel concept similarity clusters solve complex manifold problem experiments compare proposed algorithm qcc dbscan daap algorithms synthetic real world datasets results show qcc performs best superiority clustering non spherical data complex manifold data especially large
forisomes atp independent mechanically active proteins fabaceae family also called leguminosae proteins located sieve tubes phloem function prevent loss nutrient rich photoassimilates upon mechanical injury wounding forisomes seo sieve element occlusion gene family proteins recently shown involved wound sealing mechanism recent findings suggest forisomes could act ideal model study self assembly mechanism development nanotechnological devices like microinstruments microfluidic system frequently used space exploration missions technology enabling improvement micro instruments identified key technology nasa future space exploration missions forisomes designated biomimetic smart materials calcium energized motor proteins since forisomes biomolecules plant systems doctored genetic engineering contrast smart materials derived plants difficult modify properties current levels understanding forisomes conformational shifts respect calcium ions changes requires supplement future advances relation structure understand self assembly processes plant systems forms blood clots form occlusions prevent nutrient fluid leakage thus proves unique damage control system phloem tissue
establishing correspondences fundamental task many image processing computer vision applications particular finding correspondences non linearly deformed image pair induced different modality conditions challenging problem paper describes simple powerful image transform called local area transform lat modality robust correspondence estimation specifically tat transforms image intensity domain local area domain invariant nonlinear intensity deformations especially radiometric photometric spectral deformations experimental results show latransformed images provide consistency nonlinearly deformed images even random intensity deformations lat reduces mean absolute difference approximately different pixel ratio approximately average compared conventional methods furthermore reformulation descriptors lat shows superiority conventional methods promising result tasks cross spectral modality correspondence matching lat gains approximately improvement correct detection ratio improvement recognition rate tasks rgb nir cross spectral template matching cross spectral feature matching respectively lat reduces bad pixel percentage approximately root mean squared errors task cross radiation stereo matching lat also improves cross modal dense flow estimation task terms warping error providing error reduction
aim irisin adipomyokine released mainly exercised muscles participate browning adipose tissue contribute restriction insulin resistance diabetes mellitus development limited reports describing effect irisin inflammation immunocompetent cells activation present study attempted assess influence various irisin concentrations basic macrophage activity main methods studies carried murine raw macrophages cultured medium enriched irisin general cell activity viability proliferation assessed along phagocytosis process respiratory burst generation key finding irisin level positively correlates general cell activity cell cycle progression well phagocytosis intensity negatively correlates intensity respiratory burst generation influence irisin quiescent cell viability including apoptosis necrosis observed significance research first show irisin modulates macrophage activity reducing reactive oxygen species ros overproduction could suggest potential anti inflammatory properties therefore studies needed evaluation influence irisin immunocompetent cell function elsevier inc rights reserved
dyke construction dealed geotextile encased sand columns dyke used enclose polder hamburg finkenwerder germany help geotextile columns used soft soils even undrained shear strength without excessive bulging system installed dike filled immediately analysis observed data long term settlements dyke three stages gotten primary settlements secondary settlements creep settlements settlements occurred primary filling little settlements appeared construction accomplished settlement rate decreases first settlement stage last one jump takes place unloading soft soil furthermore method shorten time saved lot money
background high performance anti hepatitis virus hev igg assays crucial epidemiology objective evaluate performance prototypes developed vidas automatic system detecting anti hev igg one based orf antigen orf prototype orf orf antigens orf prototype reference wantai anti hev igg assay study design sensitivity assay determined testing blood samples immunocompetent immunocompromised patients proven hev infection defined detecting hev rna specificity assessed blood samples wantai assay indicated negative anti hev igm igg negative hev rna cross reactivity assessed using samples positive hepatitis virus igg hepatitis virus antibodies hepatitis virus antigen anti hbc antibodies rheumatoid factor negative anti hev igg wantai assay results sensitivities immunocompetent patients orf orf wantai immunocompromised patients orf orf wantai vidas prototypes detected low concentrations anti hev igg overall specificity orf prototype orf prototype vidas prototypes cross reacted five samples mainly containing hcv antibodies rheumatoid factor conclusion vidas prototypes performed well appear suitable routine detection anti hev igg elsevier rights reserved
group identification predicts adherence group norms values beliefs behaviors ability accurately perceive another degree group identification may important predicting beliefs actions two studies examine friends accuracy bias rating identification social categories friends asked rate one another identification state studies national global citizen study social identities across studies friends shown accurate biased rating one another identification thus although friends may project identification onto friend bias friends also able accurately predict one another degree connection social groups furthermore friends greater frequency contact found increase accuracy prediction together results provide initial evidence future research examining person perception intergroup interactions
mutations calr recently detected jak negative myeloproliferative neoplasms mpns key pathological drivers diseases calr mutated mpns shown numerous clinicopathological differences jak mutated mpns basis differences poorly understood unknown whether differences result directly differences intracellular signalling abnormalities induced jak calr mutations whether relate phenomena differing spectrum genetic lesions two groups aimed review clinicopathological molecular features calr jak mutated mpns samples referred diagnostic testing using custom designed targeted next generation sequencing ngs panel eighty nine calr mutated cases compared jak mutated cases calr mutated mpns showed higher platelet counts female predominance compared jak mutated mpns cohort also observed differences calr mutation subtypes terms disease phenotype mutational frequency allelic burden type calr mutations found common myelofibrosis associated higher frequency number additional mutations higher mutant allelic burden compared type calr mutations despite biological differences molecular characterisation suggests calr jak mutated mpns broadly similar terms quantity frequency spectrum occurring mutations therefore observed biological differences likely heavily influenced nature quantity mutated genes
introduction selected proportion chronic obstructive pulmonary disease copd patients managed secondary care aim study characterize disease severity treatment structure secondary care copd sweden methods information collected existing secondary care units respiratory medicine sweden using individual data consecutively enrolled copd patients global initiative obstructive lung disease gold stage iii structural questionnaire available resources units patient data included exacerbations health status assessed copd assessment test cat lung function comorbid conditions pharmacological treatment vaccinations structural data included available smoking cessation support multi disciplinary rehabilitation physical training patient education routine follow exacerbations respective unit patients reclassified according gold group classification multiple linear regression investigated associations available resources number exacerbations cat score results according gold population gold gold triple inhaled therapy prescribed patients units resources smoking cessation multidisciplinary rehabilitation physical training patient education routine follow exacerbations available units managed units access structured patient education associated statistically significantly fewer exacerbations adjusted regression coefficient confidence interval conclusion stage iii copd patients managed secondary care respiratory units sweden maximized inhaled therapy high risk disease even reclassified according gold units access smoking cessation rehabilitation patient education patients managed units structured patient education lower exacerbation risk
little known link child abuse health risk behaviors among chinese college students cross sectional study examined prevalence child abuse relations individual clusters health risk behaviors among chinese college students total students participated survey prevalence child abuse highest lowest emotional neglect physical neglect emotional abuse physical abuse sexual abuse respectively males likely report child abuse females males emotional abuse associated internet addiction suicidal behavior sexual abuse associated internet addiction females emotional abuse significantly associated increased risks self harm behavior suicidal behavior physical abuse related risks internet addiction significantly two step cluster analysis showed participants clusters health risk behaviors reported higher scores child abuse findings suggest child abuse associated individual clustering health risk behaviors among chinese college students
paper discusses diffusion pulsed magnetic field resistive element fabricated low carbon steel developed numerical model shows process magnetic field diffusion steel leading edge pulse conventionally described three stages initial stage extending saturation steel surface layers stage saturation discharge current diffuses bulk steel stage conduction discharge current distributed practically uniformly steel approximate analytical relations describing voltage drop across resistive element derived three stages relations used estimation effect ferromagnetic properties steel transients electrical circuits resistive element experiments prove validity obtained analytical results
present study aims investigate feasibility using time reversed lamb wave new method noninvasive characterization long cortical bones group velocity time reversed lamb wave launched using modified time reversal method measured bovine tibiae correlations bone properties tibia examined group velocity time reversed lamb wave showed significant positive correlations bone properties best univariate predictor group velocity time reversed lamb wave cortical thickness yielding adjusted squared correlation coefficient results imply group velocity time reversed lamb wave addition velocities first arriving signal slow guided wave could potentially used discriminator osteoporosis elsevierltd rights reserved
develop linear representation theory bicircular matroids chief example matroid associated forests graph bicircular lift matroids chief example matroid associated spanning forests bias lift matroids contrabalanced biased graphs theory expressed largely terms antivoltages edge labellings defy kirchhoff voltage law values multiplicative additive group scalar field emphasize antivoltages values cyclic groups finite vector spaces since crucial representing matroids finite fields integer valued antivoltages bounded breadth since crucial constructions find bounds existence antivoltages solve examples results number antivoltages abelian group polynomial function group order number integral antivoltages bounded breadth polynomial breadth bound conclude application complex representation many open questions elsevier inc rights reserved
paper proposes novel high speed visual target tracking system based mixed rotation invariant description mrid skipping searching method mrid novel rotation invariant description texture edge information annular histograms dominant direction overcomes rotation variant large computation issues conventional lbp hog feature description skipping searching method used tracking remarkably decrease computation time avoiding repeated searching operations proposed tracking system contains image sensor hierarchical vision processor actuator dimensions freedom dof vision processor integrates processors pixel row level parallelism speed tracking algorithm experiment results show proposed system achieve fps processing speed tracking algorithm resolution image
purpose review review catalog many recent longitudinal studies investigated relationship asthma lung function persistence trajectories lung function deficits recent findings recent work reported year follow ups prominent population cohorts history asthma confers fold risk chronic obstructive pulmonary disease individuals reaching reduced maximum growth forced expiratory volume early adulthood risk early severe chronic obstructive pulmonary disease copd summary taken together wealth overlapping cohort studies lung function asthma copd show asthma associated reduced lung function may start infancy prenatally persists childhood adulthood predisposes early severe copd
area deer antler evaluation trophy homologation well obtaining biometric databases later analysis field geometric morphometrics different linear biometric tools traditionally used study used two sets antlers iberian red deer cervus elaphus hispanicus develop establish new photogrammetric technique creates model antler using parametric computer aided design cad simple reliable method deer hunting trophy homologation compared two extensively used methods antler measurement traditional measuring tape articulated arm coordinate measuring machine aacmm cma advantage innovative photogrammetric method use two photographs obtain model dimensions required antler evaluation procedure performed compare lengths antler evaluation hunting trophy three methods showed similar reliability although photogrammetric process using cad system much faster functional traditional measuring tape articulated arm methods since method requires two photographs per individual makes possible study high percentage antlers field new photogrammetric method successfully used biometrics area could become extensively used method fields ease operation speed accuracy data collection iagre published elsevier ltd rights reserved
individuals seek social engagement others shy away profound implications normal pathological human behavior evidence suggests oxytocin paramount human social hormone governs release contribute individual differences social skills intense social involvement extreme avoidance characterize autism explore neurochemical underpinnings sociality expression peripheral blood leukocytes pbl measured han chinese undergraduates first mrna levels correlated lower autism quotient indicating enhanced social skills assesses extent autistic like traits including propensity dexterity needed successful social engagement general population second three eqtl snps gene region associated expression paralogue contiguous chromosome third association also observed eqtl snps expression full model expression eqtl snps altogether account substantial variance sociality fourth functionality eqtl snps suggested significant association plasma oxytocin immunoreactivity products fifth ecological validity findings demonstrated subjects higher pbl expression friends especially males furthermore sequence variation predicts scores friendship questionnaire summarize study uniquely leveraging various measures reveals salient elements contributing nonkin sociality friendship revealing likely pathway underpinning transition normality psychopathology elsevier ltd rights reserved
hereditary angioedema hae rare autosomal dominant disorder caused mutations serping factor genes potentially fatal particularly identified early stage apart androgens contraindicated children pregnant women range effective albeit expensive treatments recently become available hae patients cost new treatments beyond reach developing countries time cure disorder spite mutations serping gene autoimmunity infections prominent features condition present argument hae viewed primarily metabolic liver disorder conceptual paradigm shift stimulate basic research may facilitate new therapeutic approaches hae outlined paper suggest several novel potential treatment options hae perspectives clinical immunology molecular biology liver transplantation many offer prospect curing disorder effectiveness options rapidly improving many cases risks decreasing given high costs treating hae curative options may become feasible next decade
computer science education teaching computer programming beginners remains one greatest challenges due nature first year students characterized preparedness poor academic background moreover traditional lecture based approach used computer laboratories rarely used consequently students motivated engaged active participation teaching approach failed achieve learning outcome incorporating cutting edge practices like agile methods teaching could valuable stems widespread practice acceptance agile methods software industries today though agile practices like pair programming impacted students programming projects none reported teaching therefore paper proposes new approach teaching using agile methods goal assist beginners acquire needed programming skills proffer teaching technique maximizes chances engagement active participation improving teaching reflecting taught students learning additionally beginners able operate computer write correct code gain better programming skills assist teachers manage large classes effectively achieve study adopted framework decoding discipline
mapreduce promising distributed computing platform large scale data processing applications hadoop mapreduce considered one extensively used open source implementations mapreduce frameworks flexible customization convenient usage despite advantages relatively slow running task called straggler task impedes job progress study two novel speculative strategies namely estimate remaining time using linear relationship model erul extensional maximum cost performance exmcp developed improve estimation remaining time task erul dynamic system load aware strategy using strategy overcome drawbacks longest approximate time end late misleads speculative execution cases exmcp different slot values considered extensive experiments show erul exmcp applied accurately estimate remaining execution times running tasks reduce running time job elsevier ltd rights reserved
femoroacetabular impingement fai condition subtle deformities femoral head acetabulum hip socket result pathological abutment hip motion fai common cause hip pain lead acetabular cartilage damage osteoarthritis patients fai surgical intervention indicated improve quality life potentially delay onset osteoarthritis patients however surgery contraindicated significant cartilage damage already occurred unfortunately current imaging modalities rays conventional mri subjective lack sensitivity distinguish two groups reliably paper describe pairing mapping data investigational objective mri sequence spatial proportional odds model surgically obtained ordinal outcomes beck scale cartilage damage hip study assigned spatial dependence parameter dirichlet process prior distribution permits clustering said parameters using fitted model produce six color patient specific predictive map entire acetabular cartilage maps facilitate patient education clinical decision making copyright john wiley sons ltd
work influence hydrogen blending gasoline spark ignition engine surveyed means quasi dimensional simulations cycle cycle variations greatly affect performance type engines specially lean conditions reduction cyclic variations eventually would lead better performance records reduced consumption emissions one option reduce fluctuations amplitude blending gasoline component high flame laminar speed hydrogen hand quasi dimensional simulations probed powerful technique investigate cycle cycle variations parallel bench engine experiments work propose quasi dimensional scheme incorporates flame wrinkling effects associated hydrogen blending gasoline model validated direct comparison experimental results indicated mean effective pressure long time series power output calculated found lean mixtures amplitude oscillations decreases increasing percentage hydrogen volume blend minimum value optimum hydrogen concentration characteristic fuel air equivalence ratio instance fuel air ratio minimum variability amplitude located around hydrogen mixture volume optimum hydrogen concentration hydrogen energy publications llc published elsevier ltd rights reserved
limited data air quality parameters including airborne particulate matter residential green buildings increasing prevalence exposure associated cardiovascular pulmonary diseases since americans spend almost time indoors residential exposures may substantially contribute overall airborne exposure objectives measure various fractions longitudinally apartments multi family green buildings natural building mechanical building ventilation compare indoor outdoor mass concentrations ratios buildings taking account effects occupant behavior evaluate effect green building designs operations indoor evaluated effects ventilation occupant behaviors overall building design mass concentrations median pmtotal higher building building higher building building particle size fractions data show building design occupant behaviors either produce dilute indoor ventilation systems combustion sources window operation important factors affecting residents exposure residential green buildings
paper feedforward proportional integral controller developed effectively control tune laser cladding melt pool geometry real time width setpoint included computer numerically controlled cnc programming making possible instantaneous change relation position time opposed conventional controllers real time information variables new concept variable setpoint different positions applied laser cladding represents great improvement use changeable geometry applications blade fabrication several experiments performed characterize behaviour system revealing key factors monitoring system image processing crucial controller laser power selected input control variable clad width chosen output width melt pool obtained based measurements cmos camera images house image processing software algorithm closed loop parameters identified experimental data matlab simulations architecture controller consists conventional feedback loop feedforward module shows low overshoot fast response times instantaneous connections laser cnc systems allow knowing relationship among exact position real setpoint melt pool values performance controller verified fabrication cladded parts variable widths real time
increased fragility described humans polycythemia vera herein describe osteoporotic phenotype associated decreased osteoblast activity mouse model another mouse polycythemia elevated circulating erythropoietin epo results important patients treated recombinant epo repo myeloproliferative syndromes recently associated increased risk fractures however presence osteoporosis patients well documented epo hormone primarily known stimulate erythropoiesis shown recently regulate bone homeostasis mice aim study examine bone phenotype mouse model compare animals polycythemia caused elevated circulating epo bone mass remodeling evaluated micro computed tomography histomorphometry jak knock mouse model human manifests polycythemia low circulating epo levels results mouse compared wild type controls transgenic mouse shows polycythemia caused increased constitutive expression epo compared jak mice decrease trabecular bone mass mice showed additional modest decrease cortical thickness cortical bone volume per tissue volume suggesting severe bone phenotype jak decreased osteoblast numbers bone formation along normal osteoclast numbers activity found mice study indicates associated low bone mass decreased osteoblast activity mice results support future studies osteoporosis affected humans polycythemia caused chronically elevated circulating epo also results bone loss implications patients treated repo evaluated
antibody drug conjugates adcs comprise antibody linker drug payload selection tumor specific antibody development linker efficient controlled drug release cdr critical steps developing fully functional effective adc research strategy molecular imaging technologies employed evaluate efficiency antibody delivery cdr linker preclinical setting antibody delivery tumor area antibody penetration tumor stroma malignant lymphoma pancreatic tumor evaluated vivo fluorescence imaging technique positron emission tomography pet imaging studies conducted using labeled antibody evaluate tumor targeting spontaneous carcinogenesis model model dense stroma pathophysiologically similar human cancer drug imaging system using microscopic mass spectroscopy mms enhanced resolution sensitivity used evaluation cdr paclitaxel ptx incorporated micelle high molecular weight hmw carrier cdr showing similar properties adc analyzed contrast free ptx micelle selectively increased drug accumulation tumor reduced toxicity normal tissues enhanced permeability retention epr effect drug imaging system used recently evaluate cdr adc linker present work development adc using molecular imaging technique
objectives psychopathy distinct personality organization differs antisocial personality disorders many aspects diagnosis challenging also critical predict criminality context psychopathy checklist revised pcl useful tool diagnosis psychopathy reliability validity shown various populations studied turkish population aim demonstrate reliability validity pcl sample turkey methods male subjects antisocial personality disorder controls without psychiatric diagnoses included study dsm diagnostic criteria used pcl administered participants reliability turkish version pcl determined test retest internal consistency methods roc analysis performed pcl dsm criteria taken gold standard sensitivity specificity cut values pcl estimated evaluate adequacy scale construct validity exploratory factor analysis kaiser meyer olkin kmo barlett tests applied reproducibility test evaluated pearson correlation coefficient testing performed subjects two weeks first test results reliability analysis cronbach alpha internal consistency coefficient calculated alpha pearson correlation coefficient test retest item total correlations ranged sensitivity specificity respectively cut point principal component analysis two factors eigen values greater two factors accounted variance pcl scores conclusions turkish pcl valid reliable measure psychopathy detect psychopathic traits however studies psychopathy need conducted different turkish sample groups
constant tension towing winch maintains constant towing rope tension cable ship cable laying machine paper active constant tension controller based upon hybrid fuzzy strategy proposed improve performance yield conventional pid controller implemented towing winch fuzzy controller replaces item conventional pid fuzzy item items remain unchanged comparative studies fuzzy traditional pid controllers conducted numerical simulation results show performance proposed fuzzy controller superior pid controller proposed fuzzy controller implemented constant tension towing winch substitute existing pid controller real applications driving submarine cable laying ship harsh undersea conditions demonstrated robustness fuzzy number unmeasurable disturbances buoyancy drag force wave effects
conditions chronic rhinitis urticaria angioedema asthma frequently seen clinics hospitals core group medications often used treat conditions knowing indications optimal dosing side effect profile medications improve outcomes chronic rhinitis due various causes one common reasons primary care physician visits knowing indications use forms administration side effect profiles medications help improve patient outcomes common conditions article focuses medications used treat conditions
router discovery ipv vulnerable rogue router advertisements ras wherein unintended possibly incorrect ras make way network ipv host obtains several important information like default router address prefix autoconfiguring ipv address incorrect data fields result operational problems network occur result misconfigurations malicious intentions variation security threat occurs form node sending rogue spoofed address legit router router lifetime field set zero causes legit router removed default router hosts subnet malicious node could advertise default router essentially perform man middle mitm attack paper demonstrates possibility ipv testbed presents possible solution prevent implementation solution done linux kernel results testifying solution presented
objective paper upgrade wireless sensing unit meet following requirements improvement system powering analog signal processing enhancement signal resolution provide reliable wireless communication data enhance capability continuous long term monitoring based prototype wireless sensing unit developed prof lynch stanford university following upgrading steps summarized reduce system noise using smd passive elements preventing coupling digital analog circuits increasing capacity power improve adc sampling resolution accuracy higher resolution analog digital converter adc bits adc programmable gain amplifier improve wireless communication using wireless radio xtend supported router digi mesh communication function using mhz frequency band based upgrade wireless sensing unit verification new wireless sensing unit conducted ambient vibration survey base isolated building new upgrade wireless sensing unit provide reliable data continuous structural health monitoring incorporated identification software modified stochastic subspace identification method smart sensing system shm developed
series based macroinitiators bromo initiation sites equator developed synthesis star poly isopropylacrylamide star pnipam atom transfer radical polymerization taking advantage exceptional binding affinity core star pnipam used host macromolecule construct large compound vesicles presence protonated butylamine deprotonated butylamine detached core destructs vesicular structures star pnipam thermoresponsive properties adjusted simply changing formation destruction inclusion complexes core butylamine results suggest prepared star pnipam shows temperature responsiveness great potential design dual response smart material
present straightforward yet effective method modulate termination impedance resonating arrays wireless power applications modulation method based activating deactivating last two cells array allowing remove power nulls caused standing waves inside type arrays modulation terminating impedances done distinct frequency resonance frequency cells explain distinct frequency chosen demonstrate modulation applicable wide range load resistances receiver device modulation achieved wirelessly sensing voltage delivered power supply according array receiver device located microcontroller records voltages determines terminating impedance provide highest possible efficiency receiver device changes terminating impedances set digitally controlled solid state relays proposed modulation method permitted power receiver device system efficiency anywhere length resonating array
computer programming education practice oriented well theory oriented learning goals lab work plays important role students learning however widely reported many students face great difficulties learning theory well practice paper investigates important problematic relation learning theory learning practice novice programming students phenomenographic variation theoretical analysis novice students understanding concepts combined variation theoretical analysis students programming activities shown different levels practical proficiency well different levels conceptual understandings related dimensions variation paper proposes way describe students learning practice concepts related way extends traditional use phenomenography variation theory discussing students learning practice well concepts specifically relate
triarchic model characterizes psychopathy terms three distinct dispositional constructs boldness meanness disinhibition model operationalized scales designed specifically index domains using items inventories provide coverage related constructs present study sought develop validate scales assessing triarchic model domains using items minnesota multiphasic personality inventory restructured form mmpi consensus rating approach used identify items relevant triarchic domain following psychometric refinement resulting mmpi based triarchic scales evaluated convergent discriminant validity relation multiple psychopathy relevant criterion variables offender nonoffender samples expected convergent discriminant associations evident clearly boldness disinhibition scales somewhat less clearly meanness scale moreover hierarchical regression analyses indicated mmpi triarchic scales incremented standard mmpi scale scores predicting extant triarchic model scale scores widespread use mmpi clinical forensic settings provides avenues clinical research applications contexts traditional psychopathy measures less likely administered
paper presents intelligent multi agent system aimed improving healthcare assistance elderly dependent people geriatric residences homes system based pangea multi agent architecture provides high level framework intelligent information fusion management system makes use wireless sensor networks real time locating system obtain heterogeneous data able provide autonomous responses according environment status high level development system extracts stores information plays essential role deal avalanche context data case multi agent system approach results satisfactorily agent represents autonomous entity different capabilities offers different services works collaboratively several tests performed platform evaluate demonstrate validity
korteweg vries kdv type equation used characterise dynamic behaviours shallow water waves interfacial waves two layer fluid gradually varying depth article virtue bilinear forms rational solutions three kind shapes soliton like kink bell anti bell bell shapes nth order soliton like solutions coupled kdv system derived propagation interaction solitons analyzed potential shows three kind shapes soliton like kink anti bell shapes potential exhibits two type shapes soliton like bell shapes interaction potentials display fusion phenomena
background olfaction relation mental health area growing interest brain areas linked olfaction partially overlap brain areas involved psychiatric disorders consequently study olfactory function allows explore integrity brain areas non invasive effective method accordingly aim paper review olfactory function affective anxiety disorders methods purpose extensive literature review english language studies olfactory function patients aforementioned pathologies performed using several online databases manual search relevant journals books well reference lists selected papers also performed results available data show depressed patients usually characterised preserved olfactory function except detection threshold contrasting reports found bipolar disorder studied lesser extent findings shown lack impairment cases research seasonal affective disorders scant future studies needed make conclusions anxiety disorders scarcely approached results note identification deficits obsessive compulsive posttraumatic stress disorders conclusions olfactory assessment appears complementary valuable research tool study psychiatric disorders however investigation needed improve understanding olfactory function disorders copyright karger basel
aim study determine polyphenols glucosinolates ascorbic acid content well antioxidant activity beverages base apple juice addition frozen freeze dried curly kale leaves upon enrichment frozen freeze dried curly kale naturally cloudy apple juice characterized increase phenolic compounds times accordingly antioxidant activity beverages addition curly kale ranged mol trolox obtained beverages characterized glucosinolates content ascorbic acid content results sensory evaluation colour taste consistency apple juice beverages addition kale differ significantly prior pasteurization whereas pasteurization evaluated factors decreased significantly elsevier ltd rights reserved
higher rate depletion non renewable fuels quest appropriate alternative fuel gathered great momentum though diesel engines trusted power sources transportation industry due stringent emission norms rapid depletion petroleum resources continuous effort use alternative fuels hydrogen one best alternatives conventional fuels hydrogen benefits limitations use conventional fuel automotive engine system present investigation hydrogen enriched air used intake charge diesel engine adopting exhaust gas recirculation egr technique hydrogen flow rate min experiments conducted single cylinder four stroke water cooled direct injection diesel engine coupled electrical generator performance parameters specific energy consumption brake thermal efficiency determined emissions oxides nitrogen hydrocarbon carbon monoxide particulate matter smoke exhaust gas temperature measured usage hydrogen dual fuel mode egr technique results lowered smoke level particulate emissions elsevier ltd rights reserved
important understand factors contributing directly causing sports injuries improve effectiveness safety sports skills characteristics injury events must evaluated described meaningfully reliably however many complex skills effectively investigated quantitatively ethical technological validity considerations increasingly qualitative methods used investigate human movement research purposes concerns reliability measurement bias methods using tackle rugby union example outline systematic approach developing skill analysis protocol focus improving objectivity validity reliability characteristics analysis selected using qualitative analysis biomechanical theoretical models epidemiological coaching literature expert panel comprising subject matter experts provided feedback inter rater reliability protocol assessed using ten trained raters inter rater reliability results reviewed expert panel protocol revised assessed second inter rater reliability study mean agreement second study improved comparable agreement icc studies reported inter rater reliability qualitative analysis human movement
advanced system analysis tool developed advanced reactor safety analysis paper describes underlying physics numerical models used code including governing equations stabilization schemes high order spatial temporal discretization schemes jacobian free newton krylov solution method effects spatial temporal discretization schemes investigated additionally series verification test problems presented confirm high order schemes demonstrated developed system thermal hydraulics model strictly verified theoretical convergence rates performs well wide range flow problems high accuracy efficiency minimal numerical diffusions elsevier ltd rights reserved
present bit string quantum oblivious transfer protocol based single qubit rotations protocol built upon previously proposed quantum public key protocol practical security relies laws quantum mechanics practical security reflected fact due technological limitations receiver bob transferred bit string restricted performing qubit coherent measurements also present single bit oblivious transfer based proposed bit string protocol protocol implemented current technology based optics
discrepancies among independent sources information presumably identical constructs argue reliance single perspective fill need temperament questionnaires teacher parent informants adapted popular parent caregiver child behavior questionnaire short form preschool kindergarten teachers informant correspondences low expected patterns consistent hypotheses drawn person perception models internal consistencies teacher scales adequate comparing favorably parent rated scales anticipated relations temperament scales emerged social competence tasks executive attention parent teacher informants confirmatory factor analyses conducted separately parent teacher scales supported familiar three factor model allowances made cross loadings correlated errors multigroup confirmatory factor analyses parent teacher data indicated factor structures two questionnaires similar equivalent
paper spectrally coded optical code division multiple access ocdma system using hybrid modulation scheme investigated idea propose effective approach simultaneous improvement system capacity security data formats nrz non return zero dqpsk differential quadrature phase shift keying poisk polarisation shift keying used get orthogonal modulated signal observed proposed hybrid modulation provides efficient utilisation bandwidth increases data capacity enhances data confidentiality existing ocdma systems proposed system performance compared current state art ocdma schemes elsevier inc rights reserved
background cell response outcome determined stimulatory inhibitory signals programmed cell death ligand member signaling molecules known soluble form human serum soluble spd also recognized patients types malignancy autoimmune disorders though studies spd roles allergic diseases purpose survey evaluate association spd levels eosinophil count well disease severity allergic rhinitis patients methods patients selected disease severity determined modified allergic rhinitis impact asthma aria classification mild moderate severe whole blood samples collected eosinophil count serum spd detected hematologic analyzer commercial elisa kit results patients mild moderate severe disease respectively mean levels spd eosinophil count ascertained cell significant inverse correlation determined spd levels eosinophil count moreover detected significant negative association spd levels disease severity conclusions deduced spd used helpful marker determine severity furthermore study indicated spd may inhibitory role development modulation may considered useful accessory therapeutic approach reduction progression copyright japanese society allergology production hosting elsevier
paper presents dynamic modeling performance control web server hosted private cloud cloud hosting web server variable capacity system two control inputs number virtual machines vms indicative capacity cloud admission control used regulating workload workload hosting conditions change frequently linear parameter varying lpv framework well suited derive model hosted web server obtain multiple input multiple output mimo lpv model performance metrics response time throughput converted polytopic lpv form using tensor product transformation finally design gain scheduled linear quadratic regulator controller performance guarantees optimal cost vms identification validation control experiments demonstrated open source eucalyptus cloud platform http requests generated using customized synthetic workload generator tool
asian american children exhibit stronger math reading skills white children school entry pattern motivated scholars examine early childhood determine gaps form yet date unclear parenting practices might explain asian advantage analyzing children early childhood longitudinal study birth cohort find role parenting complex asian american parents high educational expectations compared whites less engaged traditional measures parenting reading child maternal warmth parent child relationship differences matter understanding asian american white math advantage early childhood thus even age four asian american parents across ethnic subgroups play important complex role development child cognitive skills first years life
background hyperthyroidism risk factor stroke conclusive definite data relationship ischemic cerebrovascular injury hyperthyroidism study designed define whether outcomes post ischemic stroke injury influenced chronic hyperthyroidism methods two groups hyperthyroid control euthyroid rats equal numbers included study hyperthyroidism induced weeks adding thyroxine drinking water middle cerebral artery occlusion technique used induce focal cerebral ischemia neurological disability neurological deficit score nds evaluated hours rats sacrificed obtain brain triphenyl tetrazolium chloride ttc staining evans blue extravasation used quantify cerebral infarct volume cerebrovascular integrity disruption data analysis done using spss version results thyroid hormones levels significantly higher group controls furthermore clinical signs seen hyperthyroid patients also present group comparison data cerebral ischemia control groups showed significant increases nds cerebral infarct volume extravasation former group conclusion intensified cerebral infarct size cerebrovascular integrity disruption suggested chronic hyperthyroidism aggravated post stroke injury rats investigation required analyze pathological mechanisms underlying association cerebrovascular disease hyperthyroidism
systematic review intended identify effectiveness inclusion essential components self management education interventions support patients cancer developing skills needed effective self management disease acute immediate long term late harmful effects treatments self management education interventions included randomized controlled trials rcts containing least one eight core elements outlined research team systematic search conducted ovid medline april embase week cochrane database systematic reviews issue april cinahl psychinfo keywords searched include self management patient education patient education forty two rcts examining self management education interventions patients cancer identified heterogeneity interventions precluded meta analysis narrative qualitative synthesis suggested self management education interventions improve symptoms fatigue pain depression anxiety emotional distress quality life results specific combinations core elements inconclusive studies used combinations core elements among results conflicting thus conclusions components elements self management education interventions associated strength effects could assessed review defining core components cancer self management education fundamental elements inclusion supporting effective self management critical ensure consistent effective provision self management support cancer system
introduction due recent advancements understanding molecular pathogenesis cell malignancies explosion innovative agents development purpose review efficiently summarize novel therapies activity indolent non hodgkin lymphoma inhl targeting surface antigens signaling pathways tumor microenvironment areas covered literature search performed identify preclinical data clinical trials focused use targeted therapies inhl subtypes including follicular lymphoma marginal zone lymphoma small lymphocytic lymphoma lymphoplasmacytic lymphoma waldenstrom macroglobulinemia classes reviewed include monoclonal antibodies antibody drug conjugates immunomodulatory agents cell receptor pathway inhibitors bcl inhibitors checkpoint inhibitors chromatin epigenetic modulating agents car cells expert commentary opinions regarding strategies address prioritization novel agents entering clinical development determination rational combination therapy development novel endpoints expedite clinical development movement towards novel consolidative approaches immuno cellular therapy attempt provide curative treatment options provided also economic impact indefinite therapy discussed
recent years ambient intelligence ami attracted increased attention within advanced technology industry effort modernize develop intelligent reliable information system technologies detect specific object images expected expand wide range applications car detection functions intelligent transport system systems computer vision pattern recognition emerging fast continue grow together local feature detection methods paper used deep neural network dnn object category recognition extracting learning object applied deep learning vegetable object recognition explored convolutional neural network cnn evaluation results found vegetable recognition learning process cnn million iterations suitable results learning rate recognition rate respectively
background aims food important synchronizer gastrointestinal motility secretion many patients functional bowel anorectal disorders complain fecal urge stool output eating patients methods prospective observational study consecutive outpatients functional bowel anorectal disorders female years filled rome iii questionnaires depression anxiety scores physiological evaluation total segmental colonic transit time colonic transit response eating using standard kcal test meal anorectal manometry measured univariate analysis multivariate logistic regression carried according presence stool output eating results defecation eating found patients patients different according demographic characteristics sex ratio age bmi contrast lower state anxiety similar scores depression trait anxiety similar manometric characteristics anal pressure rectal sensitivity greater response eating segments colon increase frequency functional diarrhea odds ratio confidence interval levator ani syndrome odds ratio confidence interval functional bowel disorder including irritable bowel syndrome subtypes found conclusion stool output eating associated clinical disorders physiological parameters symptom associated irritable bowel syndrome higher frequency functional diarrhea copyright wolters kluwer health inc rights reserved
psychotherapy drug therapy considered useful quality life qol symptoms patients irritable bowel syndrome ibs aim study examine effects cognitive behavioral therapy cbt associated drug therapy comparison drug therapy alone qol symptoms ibs patients diarrhea predominance study randomized clinical trial ibs patients patients selected according rome iii criteria assigned two groups bowel symptom severity frequency scale qol ibs used investigate patients symptoms first group underwent cbt medication therapy second group received medication data analyzed using analysis multiple covariance two groups showed significant difference qol ibs posttreatment follow stages significant differences severity frequency ibs symptoms two groups intervention cbt accompanied drug therapy useful ibs patients diarrhea predominance however discontinuing treatment may lead recurrence symptoms
background purpose studies examined patients dementia stop attending medical consultations conducted retrospective study investigate factors associated discontinuous clinic attendance methods participants patients dementia university hospital clinics affiliated local hospital clinics compared continuous discontinuous attenders cognitive affective functions activities daily living adl also compared patients continuous discontinuous continuous discontinuous results total annual rate discontinuation mean period attendance discontinuation years scores mini mental state examination hasegawa dementia scale revised geriatric depression scale apathy scale abe behavioral psychological symptoms dementia bpsd score adl significantly worse discontinuous group continuous group patients best predictor discontinuation adl decline abe bpsd score common reason discontinuation returning family doctor cessation hospital attendance discretion conclusions identified main reasons discontinuation attendance returning family doctor cessation hospital attendance discretion best predictors discontinuation adl decline worsening bpsd significant differences discontinuation patients dementia
present approach diminish temperature induced color shifts phosphor converted leds particular discuss impact thermo optic coefficients materials constituting color conversion elements cces constancy cie chromaticity coordinates silicones comparably large thermo optic coefficient phosphors yag much smaller one hence increasing temperature lead increase differences refractive indexes phosphor matrix enhance light scattering would give reason yellowish emission thus one hand thermo optic coefficient silicone matrix considered potential source failure color temperature deviation upon device operation however hand adjusting thermo optic coefficient silicone matrix appropriate materials engineering temperature induced luminescence loss phosphor applied counterbalance shift chromaticity coordinates white light regard
investigation examined whether life satisfaction advantage married unmarried people decreased past decades whether changes contextual gender specialization explained trend contextual gender specialization defined country year specific share married women fully specialize household work author used representative data world values survey european values study integrated data set countries covering period years results showed life satisfaction advantage married decreased time among men among women furthermore decline contextual gender specialization correlated trend developed developing countries developed countries life satisfaction unmarried people increased contextual gender specialization declined whereas life satisfaction married people affected
paper presents non verbal non facial method effective communication mechanoid robot conveying emotions gestures research focuses human robot interaction using mechanoid robot possess anthropomorphic facial features conveying gestures another feature research use human like smooth motion mechanoid robot contrast traditional trapezoidal velocity profile communication conveying gestures connection motion robot perceived emotions established varying velocity acceleration mechanoid structure selected motion parameters changed systematically observe variation perceived emotions perceived emotions investigated using three different emotional behavior models russell circumplex model affect tellegen watson clark model pad model results obtained show designated motion parameters linked change emotions moreover emotions perceived user three models validating reliability three emotional scale models also emotions perceived user
paper describes implementation real time speaker independent isolated speech recognition system using hidden markov models bit arm cortex microcontroller introduce theory requirements details embedded implementation evaluation made using multi speaker isolated digit corpus argentinian spanish performance terms accuracy speed required memory compared baseline dynamic time warping recognizer implemented previously architecture test results show proposed hmm system outperforms baseline system exhibits recognition accuracy clean acoustic environment
meta analysis attempts offer overall cumulative effect estimate parental style consumer socialization relationship across studies examining child outcomes including unique consumer socialization dependent variables ranging understanding advertising practices weight status theft among approximately child respondents meta analysis offers two contributions consumer socialization literature systematically confirms influence parental restrictiveness relative permissiveness raising children adept positively interacting avoiding negative interactions marketplace related environments also meta analysis supports prior literature depiction authoritative parenting style especially important positive interactions marketplace particular among older children psychosocial type outcomes finally research first provide comprehensive confirmation differences child thinking believing choosing feeling etc attributable different parental styles published elsevier inc behalf society consumer psychology
introduction corticobasal syndrome cbs resulting genetic alzheimer disease described whether familial cbs distinct clinical entity imaging signature remains unknown methods four individuals cbs two families underwent detailed assessment two individuals regional atrophy hypoperfusion compared autopsy confirmed typical late onset corticobasal degeneration well genetically proven psen cases amnestic presentation results one family harbored novel mutation psen pheleu mri demonstrated severe parietal perirolandic temporal atrophy relative sparing frontal ipsilateral hippocampal regions autopsy confirmed pure pathology family harbored known psen mutation glyval discussion report confirms familial cbs distinct clinical entity parietal perirolandic temporal atrophy signature illustrates clinical heterogeneity occur despite shared genetic cause underscores need biomarkers amyloid imaging life published elsevier inc behalf alzheimer association
agnes hill unmarried daughter british landowner farmer mixed race wife living white farmer life colony german south west africa suddenly classified native due enforcement radical racial legislation german colony degrading offspring mixed race people bastards new classification would dire consequences whole family especially respect landownership however agnes fought family support solicitors daughter british father coming cape colony help british consul residing german colony finally succeeded securing estate family even unmarried woman predominantly patriarchal settler society using mainly material court cases article traces agnes hill fight hill inheritance thereby investigating various crucial issues colonial societies points changing boundaries white non white ambiguity racial classifications article argues women agnes hill could play significant role colonial settler societies able transcend gender role boundaries
inductance simulator useful component circuit synthesis theory especially analog signal processing applications filter chaotic oscillator design analog phase shifters cancellation parasitic element study new four inductance simulator topologies employing single current feedback operational amplifier presented presented topologies require passive components first topology intended negative inductance simulation second topology lossy series inductance third one negative lossy parallel inductance fourth topology negative parallel simulation performance proposed cfoa based inductance simulators demonstrated second order low pass filter inductance cancellation circuit pspice simulations given verify theoretical analysis
study question ulipristal acetate upa selective progesterone receptor modulator used emergency contraception interfere fertilization early embryo development vitro vivo summary answer doses similar used upa affect mouse gamete transport fertilization embryo development known already upa acts emergency contraceptive mainly inhibiting delaying ovulation however little information regarding effects post ovulatory events preceding implantation study design size duration vitro vivo experimental study involving use mouse gametes embryos least three animals set experiments participants materials setting methods vitro fertilization experiments mouse epididymal spermatozoa capacitated presence different concentrations upa used inseminate cumulus intact cumulus free eggs presence absence upa gamete incubation percentage fertilized eggs determined vivo fertilization experiments superovulated females caged proven fertile males injected upa vehicle mating percentage fertilized eggs recovered ampulla determined investigate effect upa embryo development zygotes recovered mated females cultured presence upa days progression embryo development monitored daily main results role chance vitro studies revealed presence upa capacitation gamete incubation affect fertilization whereas vivo administration upa time hcg injection produced decrease number eggs ovulated compared controls vehicle injected animals effects fertilization observed upa administered shortly mating differences observed either percentage cleaved embryos cleavage speed upa present vitro embryo culture limitations reasons caution considering ethical technical limitations inherent use human gametes fertilization studies mouse model used approach exploring potential effects upa vivo sperm transport fertilization nevertheless extrapolation results humans requires investigation wider implications findings study presents new evidence lack effect upa gamete interaction embryo development providing new insights mechanism action upa emergency contraceptive method potential clinical implications new findings could contribute increase acceptability proper use upa emergency contraceptive method
genii river basin southern spain agriculture greatest pressure freshwater demand furthermore water degradation caused soil erosion becoming key environmental concern study aims assess water related impacts agriculture combining use ecohydrological model swat spatiotemporal water footprint assessment evaluate current status streamflow blue water soil water green water assimilability sediments streamflow grey water footprint common agricultural policy cap requires farmers adopt certain agricultural practices beneficial environment practices could affect conditions available land water resources importance applying best land management practices maintenance sustainable water resources study also infers probable water availability water pollution level changes different post cap scenarios genii streamflow highly regulated result hard discern significant changes proposed scenarios however shift afforestation measures unproductive direct soil evaporation productive water evapotranspired water agricultural natural areas excluding non growing periods consumption probability annual evapotranspiration natural areas greater afforestation scenarios baseline scenario whereas likelihood soil water evaporation lower evapotranspiration natural areas increases september may afforestation measures compared baseline scenario whereas soil water evaporation decreases winter grey water footprint water pollution level decrease respectively highest streamflow conditions afforestation opposed current conditions however water pollution levels suspended solids greater indicate river flow capable assimilating existing sediment loads since land use changes agricultural practices major impact water resources post cap reform provide environmental benefits water allocation mitigation water pollution however efforts required better align policy goals cap water framework directive elsevier ltd rights reserved
aim study analyze effects mid cycle administration ulipristal acetate upa gene expression endometrial biopsies taken receptive phase cycle fourteen healthy menstruating women studied control non treated treated cycles single dose upa follicle diameter reached ovulation treated control cycles confirmed serial determinations serum progesterone vaginal ultrasound endo metrial biopsy day cycle taken rna microarray qpcr analysis prepared histological immunohistochemistry studies functional analysis differentially expressed genes showed presence changes compatible non receptive endometrial phenotype confirmed qpcr immunohistochemistry study suggests effects upa endometrial receptivity offering plausible explanation higher contraceptive efficacy method compared levonorgestrel elsevier rights reserved
march following robust activist campaign arysta lifescience withdrew soil fumigant methyl iodide market little year finally registered use california major part campaign registration chemical people ostensibly acting citizens rather consumers wrote public comments contesting use chemical high toxicity although comments marginal impact outcome case comments interest say public action time efforts address food agricultural issues dominated voting fork based qualitative textual analysis approximately representative comments made available show many taking action abandon consumer subjectivities associated neoliberal governmentality threatening personal boycotts acting capacity individual consumers invoking children health many also acting behalf consumers despite chemical question applied strawberries planted thus leaves residues emphasis letter writers gave bodies reinforces idea bodies count others thus reveals biopolitical sorting consumer lives matter consequential light evidence consumer concern pesticides historically led formulations regulations protective consumers workers neighbors
cases flow head loss main concern design engineers instead prefer exclude hydraulic jump super subcritical flow due unfavourable flow conditions present study investigates flow field hydrodynamic aspects transitional region super subcritical flow without hydraulic jump found inside transitional region velocity pressure profiles deviate slightly uniform flow velocity hydrostatic pressure according evaluation velocity measurements conjunction continuity equation characteristics transitional region determined furthermore reynolds stresses analysed mechanisms transition super subcritical flow without jump demonstrated qualitatively results relating profiles shear stresses vorticity total angular momentum along transition developed results indicate first short part flow field downstream transition structure floats incoming high speed fluid shear stress maximal observed downstream structure shear stresses vorticity maximal along streamlines inside shear layer vorticity spreads upward diffusive mechanisms
purpose purpose paper examine need develop building service standard method measurement bssmm would provide home ground advantage framework managing cost building services quantity surveyors design methodology approach review previous research rules measurement carried exercise provides basis questionnaire design administered quantity surveyors malaysia construction industry findings results indicated need develop bssmm total variables identified essential features standard method measurement variables grouped three categories priority ranking carried analysis revealed strong agreement among quantity surveyors priority ranking essential features bssmm research limitations implications although research would assist industry stakeholders developing bssmm reflects local international best practices need investigate rules bssmm could aligned construction industry classification systems practical implications availability information computer technology ict tools transformed traditional practices industry offered values quantity surveyors quantity surveyors tools consolidated incorporated emerging ict applications collaboration difficult requirements electronic data exchange impractical therefore type standard method measurement facilitate cross referencing coordination boq documents drawings specifications tender produced project participants thereby lay efficient foundation effective collaboration quantity surveyors bim model addition bssmm comply local industry practices also internationally compatible originality value adoption structured format based bssmm present building services cost information essential view increase value complexity building services modern buildings however need enhance quantity surveyors knowledge technology cost management building services ensure reliability cost advice provided clients goal would partly achieved education training quantity surveyors cost consultants interpretation use rules smm
important factor underlying entire eud enterprise incorporate basic computer programming school curricula rapidly increasing initiatives towards goal typically explored two kinds abilities associated learning program logical problem solving digital multimedia storytelling paper report exploratory qualitative study group middle school children one semester computational thinking acquisition class combined three technologies participants created game explored representation implicit explicit meanings game iii created scripted asynchronous web based conversation teacher game concluded combination introduce new forms person expression software basic education also importantly give teachers learners lead program reflection one powerful concepts programming computing
nearly breast tumors express estrogen receptor treated endocrine therapy selective estrogen receptor modulator serm tamoxifen aromatase inhibitors despite proven success many tumors fail respond endocrine therapy eventually recur aggressive metastatic cancers therefore preventing overcoming endocrine resistance tumors remains major clinical challenge deregulation activation nuclear factor kappa kappa pathway implicated endocrine resistance poor patient outcome tumors consequence one option improve existing anti cancer treatment regimens may introduce additional anti kappa activity endocrine therapy drugs approach design test serm fumarate targeting hybrid drugs capable simultaneously inhibiting via serm raloxifene kappa pathway via fumarate breast cancer cells find hybrid drugs display improved anti kappa pathway inhibition compared either raloxifene fumarate despite loss potency pathway hybrid drugs maintain anti proliferative activity breast cancer cells furthermore drugs prevent clonogenic growth mammosphere formation breast cancer cells proof principle simultaneous inhibition kappa via single bifunctional hybrid drug may represent viable approach improve anti inflammatory activity prevent therapy resistance targeted anti cancer drugs
purpose study explored experiences people living non specific chronic low back pain clbp rural nigerian community method qualitative depth semi structured face face interviews conducted purposively sampled participants data saturation questions explored back pain beliefs coping management strategies daily activities thematic analysis transcripts performed using framework approach results themes showed back pain beliefs related manual labour deprivation infection degeneration spiritual cultural beliefs rural urban divide beliefs impacted gender roles resulting adaptive maladaptive coping adaptive coping facilitated positive beliefs regarding clbp illness whereas viewing clbp illness stimulated maladaptive coping strategies spirituality associated adaptive maladaptive coping maladaptive coping strategies led dissatisfaction health care community conclusions clbp related disability rural nigeria strongly influenced beliefs facilitate coping strategies either enhance inhibit recovery interventions therefore target maladaptive beliefs emphasizing behavioural modification implications rehabilitation non specific chronic low back pain clbp highly prevalent responsible much pain disability rural nigeria qualitative study investigated experiences people living clbp rural nigeria rural african context qualitative study peoples experiences living clbp rural nigeria potential exposing complex socio cultural psychological factors associated clbp potential implications designing effective interventions results study may inform development complex interventions reducing disability associated clbp rural nigeria rural african contexts
background effects therapeutic relationship elder mental health understudied greater understanding geriatric psychotherapy particularly needed treating late life depression executive dysfunction predicts poor response antidepressant medication presents unique clinical challenges methods participants older patients major depression executive dysfunction received weeks problem solving therapy supportive therapy randomized control trial multilevel growth curve modeling latent change scores used analyze dimensions understanding accepting patient level individual patient ratings therapist level ratings therapist averaged across participants results predicted reduction depression treatment groups treatment interactions significant patients treated therapists higher average understanding patient therapist level accepting therapist level ratings greater decreases depression patient level therapist level interaction understanding approached statistical significance suggesting synergistic effect treatment outcome together understanding accepting predicted variance depression level changes limitations assessed throughout course treatment first therapy session post treatment include ratings objective evaluator conclusions assessment patient experience therapist ability foster understanding accepting play significant role delivery geriatric psychosocial interventions
traditional approach map accuracy assessment based error matrix capture spatial variation classification accuracy per pixel accuracy prediction methods proposed based interpolating accuracy values test sample reference class sampled pixel determined different accuracy prediction methods developed based four factors predictive domain spatial versus spectral interpolation function constant linear gaussian logistic incorporation class information interpolating class separately versus grouping together sample size developing accuracy maps using spectral domain new approach contrast previous efforts based spatial domain performance prediction methods evaluated using test blocks dimensions dispersed throughout united states block complete coverage reference data manually extracted interpreters land cover map produced landsat imagery using decision tree classification full scene maps compared corresponding reference maps produce complete coverage accuracy information block predicted accuracy maps produced sample reference data test dataset performance sample based accuracy predictions evaluated using area curve auc receiver operating characteristic relative existing accuracy prediction methods proposed methods resulted improvements auc greater evaluation four factors comprising accuracy prediction methods demonstrated interpolations done separately class instead grouping classes together classes approach used spectral domain result substantially greater auc spatial domain iii smaller sample size per class predictions spectral spatial domain yielded similar auc larger sample size dense spatial sample per class predictions spatial domain yielded larger auc increasing sample size improved accuracy predictions greater benefit accruing spatial domain function used interpolation smallest effect auc conclude ability produce per pixel accuracy predictions yielding simple understand accuracy maps opens new possibilities error propagation remotely sensed products variety disciplines elsevier inc rights reserved
conjunction conjugated twins malformation monozygotic twins described human many animal species essence lack complete separation twin organisms period prenatal development well conjunction various body parts etiology phenomenon fully examined yet main causes environment pollution problem medicine veterinary aim manuscript review research results account growing number conjunction cases well drawing attention correlation abnormality growing number twin births also crucial present connections alarming increase conjunction cases society development ecology environment cleanliness connected wellbeing safety protection animals specifically ones living wild account present investigation attention drawn necessary participation veterinary sciences research causes recommendations decreasing percentage iatrogenic multiple pregnancies problems individual selective issues sufficiently examined need investigations
paper new framework address stability preservation problem projection based model order reduction presented sufficient conditions obtaining stable reduced models established proven using notions contractivity matrix measure based results present two model reduction algorithms preserve stability using orthogonal projection addition show system classes stability preservation guaranteed choosing suitable state space representation applicable large class models obtained finite element method fem
software engineering activities information intensive research proposes information retrieval techniques support engineers daily tasks establishing maintaining traceability links fault identification software maintenance describe engineering task test case selection illustrate problem analysis solution discovery process objective study gain understanding extent techniques one potential solution applied test case selection provide decision support large scale industrial setting analyze context studied company test case selection performed design series experiments evaluating performance different techniques experiment provides lessons learned implementation execution results feeding successor three experiments led following observations lack research scalable parameter optimization techniques software engineering problems scaling techniques industry data challenging particular latent semantic analysis context poses constraints empirical evaluation techniques requiring research developing valid statistical approaches believe experiences conducting series experiments industry grade data valuable peer researchers avoid pitfalls encountered furthermore identified challenges need addressed order bridge gap laboratory experiments real applications industry
study concerns development numerical methodology initializing immersed interface based cfd solvers using complex computer aided design cad geometry cfd solvers higher order discretization stencils require larger stencil widths become problematic regions space insufficient mesh resolution available problem becomes especially challenging convoluted triangulated surface meshes generated complex solid models used initialize cut cells pragmatic balance desired local geometry resolution numerical accuracy often required find practical solution robust iterative fill algorithm presented balances geometry resolution numerical accuracy via stencil size several examples presented illustrate use initialization procedure employs original cad generated triangulated surface mesh along level set representation surface initialize cut cells boundary proximity measures creation cfd stencils convergence error analysis surface area enclosed volumes first presented show effects fill geometry function desired stencil size grid resolution algorithm applied geometrically complex problems using large eddy simulation two problems considered first flow around eiffel tower second combustion swirler context design problem copyright john wiley sons ltd
simple voltage frequency converter vfc modulated duty cycles proposed proposed vfc composed operational amplifier voltage current circuit charge discharge circuit comparator schmitt trigger duty cycle signal always obtained output schmitt trigger multiple duty cycles obtained output comparator simply adjusting external voltage level due simplicity proposed vfc circuit easily combined circuitry extend practical application errors caused circuit non idealities investigated quantify trade offs performance cost proposed vfc features modulated duty cycles realized standard complementary metal oxide semiconductor cmos technology active area mxm occupied experimental results show proposed converter useful output frequency ranges khz mhz input voltage range power consumption
purpose aim present study examine relationship peripheral bone marrow levels clinicopathologic characteristics laboratory parameters myeloproliferative disease mpd patients patients methods total mpd patients enrolled study examined relationship bone marrow peripheral levels patients clinicopathologic laboratory parameters results significant correlations peripheral levels jak mutation thrombosis white blood cells wbc lactate dehydrogenase ldh transferrin saturation ferritin bone marrow cellularity addition significant correlations bone marrow levels jak mutation thrombosis wbc ldh ferritin bone marrow cellularity identify significant relationship peripheral bone marrow levels however significant correlations peripheral levels bone marrow fibrosis bone marrow levels constitutional symptoms bone marrow levels bone marrow fibrosis conclusion find significant relationship clinicopathologic laboratory characteristics peripheral bone marrow cells bone marrow fibrosis patients also significant relationship bone marrow cells peripheral cells peripheral cells may originate spleen rather bone marrow may given different result parameters
increasing concerns regarding oil spills air pollution climate change associated fossil fuel use increased urgency search renewable clean sources energy assessment describes potential ocean thermal energy conversion otec produce clean energy also potable water refrigeration aquaculture products higher oil prices recent technical advances improved economic technical viability otec perhaps making technology attractive feasible past relatively high capital costs associated otec may require integration energy food water production security small island developing states sidss improve cost effectiveness successful implementation otec scale require application insights analytical methods economics technology materials engineering marine ecology disciplines well subsidized demonstration plant provide operational data near commercial scales elsevier ltd rights reserved
osteoarthritis multifactorial disease recent data suggested cell cycle related proteins play role pathology cyclin dependent kinase cdk inhibitor regulates activation cdks recently reported deficiency induced susceptibility induced destabilization medial meniscus dmm surgery stat signaling activation however mechanisms associated deficiency led susceptibility stat pathway remain unknown therefore focused joint inflammation determine mechanisms associated function vitro vivo progression knockout mice used develop vivo model cbl mice background mice used controls morphogenic changes measured using micro serum levels detected elisa histological immunohistological analyses performed results indicated deficient dmm model mice exhibited significant subchondral bone destruction cartilage degradation compared wild type mice immunohistochemistry results revealed mice susceptibility changes accompanied macrophage infiltration enhanced mmp mmp expression induced signaling mice also showed subchondral bone destruction according micro analysis cathepsin staining revealed increased numbers osteoclasts furthermore mice displayed increased serum levels isolated chondrocytes mice indicated elevated mmp mmp expression phosphorylation kinase complex response stimulation whereas treatment specific kinase inhibitor attenuated mmp mmp expression results indicated deficient dmm mice susceptible alterations phenotype including enhanced osteoclast expression macrophage infiltration mmp expression induced signaling suggesting regulation may constitute possible therapeutic strategy treatment american society bone mineral research
background evacetrapib potent selective inhibitor cholesteryl ester transfer protein cetp development treatment cardiovascular disease purpose pre postnatal study rabbits evaluate effects evacetrapib pregnancy parturition lactation maternal animals growth viability development reproductive performance first filial offspring rabbit considered relevant species toxicity testing evacetrapib demonstrates significant cetp expression whereas mice rats express significant levels cetp methods evacetrapib administered daily oral gavage gestation day lactation day dose levels day results adverse effects maternal survival clinical signs gestation length parturition litter size effects clinical observations body weight sexual maturation conditioned eye blink functional observational battery pathology findings treatment related decreases postnatal survival equivocal reductions mating fertility copulation conception indices without changes sperm parameters pathology reproductive organs noted animals conclusions maternal observed adverse effect level noael evacetrapib administration female rabbits day based decreased postnatal survival equivocal changes fertility noael neonatal developmental day wiley periodicals inc
objectives hypothesis predicting prognosis idiopathic sudden sensorineural hearing loss isshl remains challenging investigation aimed apply framingham risk scores frs assess combination prognostic factors following isshl investigate predictive role frs patients multiple comorbidities including hypertension diabetes hyperlipidemia study design retrospective study methods twenty one patients presenting unilateral idiopathic sudden sensorineural hearing loss multiple comorbidities surveyed framingham risk score calculated patients assigned high risk frs low risk frs groups mean pure tone audiometry pta threshold groups hearing outcomes following established criteria investigated patients treated protocol oral methylprednisolone results overall successful recovery rate complete marked recovery mean pta threshold low risk group showed significant improvement mean pta standard error pretreatment posttreatment high risk group show significant improvement mean pta threshold mean pta pretreatment posttreatment conclusion framingham risk scores may useful predicting outcomes isshl patients multiple comorbidities
compressed air energy storage technologies improve supply capacity stability electricity grid particularly fluctuating renewable energies massively connected incorporating combined cooling heating power systems compressed air energy storage could achieve stable operation well efficient energy utilization paper novel combined cooling heating power based compressed air energy storage system proposed system combines gas engine supplemental heat exchangers ammonia water absorption refrigeration system design tradeoff thermodynamic economic objectives overall exergy efficiency total specific cost product investigated evolutionary multi objective algorithm proposed combined system found increase exergy efficiency total product unit cost less affected beginning rises substantially afterwards best trade solution selected overall exergy efficiency total product unit cost cent kwh respectively variation decision variables exergy efficiency indicates compressor turbine heat exchanger preheating inlet air turbine key equipment cost effectively pursuit higher exergy efficiency also revealed exergoeconomic analysis best trade solution investment costs compressor two heat exchangers recovering compression heat heating compressed air expansion reduced particularly latter thermodynamic performance gas engine need improved significantly elsevier ltd rights reserved
background preclinical studies identified certain probiotics psychobiotics live microorganisms potential mental health benefit lactobacillus rhamnosus shown reduce stress related behaviour corticosterone release alter central expression gaba receptors anxious mouse strain however unclear single putative psychobiotic strain psychotropic activity humans consequently aimed examine promising preclinical findings could translated healthy human volunteers objectives determine impact rhamnosus stress related behaviours physiology inflammatory response cognitive performance brain activity patterns healthy male participants methods week randomized placebo controlled cross design employed twenty nine healthy male volunteers participated participants completed self report stress measures cognitive assessments resting electroencephalography eeg plasma beta tnf alpha levels whole blood toll like tlr agonist induced cytokine release determined multiplex elisa salivary cortisol determined elisa subjective stress measures assessed socially evaluated cold pressor test secpt results overall effect probiotic treatment measures mood anxiety stress sleep quality significant effect probiotic placebo subjective stress measures hpa response secpt visuospatial memory performance attention switching rapid visual information processing emotion recognition associated eeg measures show improvement placebo significant anti inflammatory effects seen assessed basal stimulated cytokine levels conclusions rhamnosus superior placebo modifying stress related measures hpa response inflammation cognitive performance healthy male participants findings highlight challenges associated moving promising preclinical studies conducted anxious mouse strain healthy human participants future interventional studies investigating effect psychobiotic populations stress related disorders required elsevier inc rights reserved
purpose investigated efficacy alpha blockers different affinities alpha adrenoceptor subtypes silodosin naftopidil treatment benign prostatic enlargement complicated overactive bladder materials methods prospective open label randomized multicenter study outpatients untreated benign prostatic enlargement associated urinary urgency least per week oabss overactive bladder symptom score greater patients randomly assigned receive silodosin per day naftopidil per day changes parameters baseline weeks assessed based pss international prostate symptom score pss quality life oabss voiding functions measured uroflowmetry results efficacy analysis total patients included groups significant difference adverse effects observed groups mean pss pss quality life scores oabss significantly improved groups statistically significantly greater improvement silodosin group naftopidil group observed total oabss pss quality life score oabss urgency score adrenoceptor blocker
proteins one versatile modular assembling systems nature experimentally protein structures identified deposited every day protein data bank enormous structural variety first approximation controlled sequence amino acids along peptide chain protein understanding structural functional properties target encoded sequence main objective protein design unfortunately rational protein design remains one major challenges across disciplines biology physics chemistry implications solving problem enormous branch materials science drug design evolution even cryptography instance field drug design effective computational method design protein based ligands biological targets viruses bacteria tumour cells could give significant boost development new therapies reduced side effects materials science self assembly highly desired property soon artificial proteins could represent new class designable self assembling materials scope review describe state art computational protein design methods give reader outline developments could expected near future
proposed conceptual model arguing stereotype violation stereotype activation combine create narrow band acceptable career strategies women management utilizing sample chinese managers pairs women men matched education years work experience employing organization examined effects gender three career development outcomes number subordinates supervised life satisfaction career satisfaction results indicated female significant negative main effect three outcomes ten significant interactions supported theoretical effects stereotype violation activation women managerial career development consistent conceptual model findings suggest chinese women management face narrow band acceptable career strategies especially area creating social capital results highlight importance testing stereotype violation stereotype activation effects creating social capital appropriate networking
magneto rheological gel mrg kind smart material fabricated dispersing ferromagnetic particles high viscosity polymer gel internal particles mrg uniformly dispersed state precondition external applied magnetic field particles form reversible chain like structure process electrical resistivity mrg immense change order deeply understand changing mechanism magneto resistance mrg theoretical model based magnetic dipole behavior percolation theory proposed work model incorporates parameters magnetic field intensity carbonyl iron powder cip volume fraction effort explore magneto resistance properties mrg series experimental testing conducted magneto resistance properties mrg different cip volume fractions different magnetic fields investigated experimental results indicated conductivity mrg significantly increased increasing magnetic field cip volume fraction addition order verify effectiveness proposed theoretical model experimental measured results theoretically obtained results compared validation results demonstrated theoretical model proposed work capable reproducing field dependent magneto resistance properties mrg elsevier rights reserved
prenatal development epididymis studied bovine fetuses ranging crown rump length crl pcd studies aimed apply glycohistochemistry immunohistochemistry detection differentiation developing prenatal epididymis conventional histological histochemical techniques applied paraffin sections epididymis different fetal stages establishment urogenital junction extra testicular rete testis mesonephric duct via growing efferent ductules ductuli efferentes first evident fetuses crl fetal age pcd crl mesonephric duct began lengthen coil forming three distinct regions caput corpus cauda addition macroscopical modifications extra testicular excurrent duct system histological differentiation involved tubular epithelial peritubular mesenchymal cells epithelium lining efferent ductules differentiated ciliated non ciliated columnar cells simple epithelium epididymal duct increased height developed stereocilia apical surface additionally basal cells first appeared pcd crl within epithelium lining cauda lectin histochemistry wga pna gsa showed early immunostaining epithelium efferent ductules peritubular mesenchymal structures immunoreactivity different proteins fibroblast growth factor factor angiotensin converting enzyme laminin alpha smooth muscle actin evident epithelial peritubular mesenchymal cells early pcd basis histochemical observations conclude glycohistochemistry immunohistochemistry useful tools demonstrate differentiation peritubular structures efferent ductular epithelium begins earlier components elsevier gmbh rights reserved
designing developing web enabled remote laboratories pedagogical purposes easy task often developers generally educators know subjects teach lack technical programming skills required build internet based educational applications end discarding idea exploring new teaching learning experiences mainly due technical issues must mastered tackle problem authors present novel technique allows developers create remote labs quick didactical straightforward way framework based use two well known software tools scope engineering education easy java simulations labview development exploits new feature easy java simulations known ejs elements enables java developers create integrate authoring libraries elements ejs thus increasing application possibilities particularly ejs element presented allows labview programs controlled ejs applications communication network paper presents element creation details used create web enabled experimentation environments educational purposes step step example development remote lab automatic control education described
past studies identify five factor model ffm domains characteristic borderline personality disorder bpd including associated specific bpd symptoms person level present study replicated person associations extended past research assessing whether ffm explains within person variance manifestation momentary bpd symptoms presence absence close social contact csc measured csc bpd core symptoms negative affectivity impulsivity interpersonal problems bpd patients clinical control group depressed patients course days times day ffm domains showed specificity predicting momentary bpd symptoms interacted csc particular bpd individuals momentary impulsivity interpersonal problems associated higher neuroticism extraversion lower agreeableness associations especially strong situations involving csc negative affectivity predicted neuroticism groups individuals association generally unaffected csc overall experiencing csc positively associated momentary bpd symptoms thus ffm csc associated bpd patients experience symptoms everyday life furthermore specific ffm trait domains particularly impactful contexts bpd symptoms likely manifested providing evidence person situation interactions important understanding bpd symptoms moment
universal biquadratic filters employing operational transresistance amplifiers presented different second order filtering functions namely low pass high pass band pass notch pass realized quality factor filters adjusted electronically without affecting resonant frequency configuration made fully integrated based mos realization making use current differencing internally grounded inputs otra pspice simulation results given verify theoretical analysis
present mini review cognition prader willi syndrome studies cited include findings general ability correlates family members strengths weaknesses cognitive profiles genetic subtypes attainment literacy numeracy language comprehension modality preferences executive functions social cognition latter includes investigations theory mind emotion recognition face processing knowledge social norms results research mouse models brain imaging studies relevant cognition briefly discussed importance studies understanding managing education behaviour pws limitations studies terms small numbers non representativeness lack replication also touched upon elsevier ltd rights reserved
according switching rules iso using method signal flow graph combined probability generating function paper derives formulas scheme operating characteristic curves average scheme sample number iso based formulas calculate performance measures using sas code
present work organic inorganic hybrid nanostructures comprised polyaniline vanadium oxide synthesized via simple hydrothermal technique polyaniline vanadium oxide hybrid morphology tailored rods spheres controlling relative concentration reactants synthesized composites characterized ray diffraction xrd fourier transform infrared spectroscopy ftir field emission scanning electron microscopy fesem structural morphological analyses electrorheological properties prepared nanocomposites suspended silicone oil investigated rotational viscometer steady dynamic shear activity composite material suspensions showed higher effects product rod like structures product sphere like structures typical behaviour showed polyaniline vanadium oxide nanocomposites demonstrated potential application smart material
managing acute intracerebral haemorrhage challenging task physicians evidence shows outcome improved admission acute stroke unit active care including urgent reversal anticoagulant effects potentially intensive blood pressure reduction nevertheless many management issues remain controversial including use haemostatic therapy selection patients neurosurgery neurocritical care extent investigations underlying causes benefit versus risk restarting antithrombotic therapy episode intracerebral haemorrhage
purpose study explored turkish university students views women related issuesgender roles sexuality violence women method cross sectional study conducted students females malesat ankara university turkey survey exploring students views female sexuality violence used comparisons responses made among groups based sex year study university field study university results three relevant findings found male students traditional nonegalitarian approaches toward women issues female students educational levels fields study significantly influence students views women small percentage students approve violence women discussion results show patriarchal values turkish society influence formation students opinions university education alone affect everyone views gender roles women sexuality violence women
background cognitive impairment still occurs substantial subset hiv infected patients despite effective viral suppression highly active antiretroviral therapy haart structural brain changes may provide clues underlying pathophysiology study provides detailed spatial characterization pattern extent brain volume changes associated hiv relates brain measures cognitive ability clinical variables methods multiple novel neuroimaging techniques deformation based morphometry voxel based morphometry cortical modeling used assess regional brain volumes hiv infected patients hiv uninfected individuals ninety percent hiv infected patients stable haart plasma viral suppression brain volumetrics cortical thickness estimates compared hiv infected uninfected groups relationships measures brain volume indices current past infection severity central nervous system penetration haart cognitive performance assessed results regionally specific patterns reduced thalamic brainstem volumes reduced cortical thickness orbitofrontal cortex cingulate gyrus primary motor sensory cortex temporal frontal lobes seen hiv infected patients compared hiv uninfected participants observed white matter loss subcortical atrophy associated lower nadir cell counts reduction cortical thickness related worse cognitive performance conclusions findings suggest distinct mechanisms may underlie cortical subcortical injury people hiv argues potential importance early initiation haart protect long term brain health
article examines different forms eliteness reflected produced discursive practices texts participant testimonials published two websites describing american university leadership development programs emphasizes way practices operate thematize differentiate forms eliteness academic administrative long tradition represented antithetical forms knowledge expertise ways life socialize participants claims one kind eliteness another examination use titles characterizations program participants pedagogical subjects narratives personal transformation skills discourses urciuoli skills selves new workplace american ethnologist analysis shows discourse implicated production reproduction neoliberal subjects perspectives institutional functions roles
water footprinting assessment water use life cycle assessment become major interest sustainability assessments various initiatives combining water resource issues consumption products services initiated last decade however comprehensive databases fulfilling requirements addressing issues lacking necessary facilitate efficient consistent assessments products services purpose ecoinvent focused integrating appropriate water use data version since previously water use data inconsistently reported essential flows missing paper describes structure water use data ecoinvent data compiled way used water footprinting main changes required proper assessment water use addition environmental product flows order allow water balance process accordance strict paradigm ecoinvent focus mass balances requires inclusion water contents products also waste water flows well emissions water soil air various water bodies water inputs air rainwater harvesting introduced yet used activity ecoinvent version consistently includes relevant flows address water use life cycle assessment lca calculate water footprints product level processes including uncertainty information although problems regarding data quality spatial resolution remain important step forward limit efforts detailed data collection sensitive processes product system combination data water use emissions water process concentration corresponding water classes also calculated assessed existing impact assessment methods comprehensive collection water use data process level facilitates proper assessment water use within lca water footprints beyond agricultural production especially lca also tools eco design specific water footprint data essential leads cost efficient way assessing consumption choices product design decisions full transparency enhances effectiveness investing data collection performing sensitivity analyses using ecoinvent data identify relevant flows processes
paper collected china green building projects completed intelligent application information technology intelligent technology application situation comparison analysis intelligent technology use green building country present compared papers article single building application smart technology analyzed regional angle regional green architecture application intelligent technology china classified contrast better show use intelligent technology green building time also different areas green building project participants comparison screening green building projects smart technology provides meaningful reference
study examines main moderating effects childhood abuse neglect severity income family social support presence postpartum depressive symptoms pds participants included postpartum mothers endorsed history childhood maltreatment enrolled longitudinal study mother child outcomes participants completed questionnaires assess severity associated societal maternal characteristics depressive symptom severity results confirm previously identified links severity pds hierarchical linear regression analyses indicate interaction household income interpersonal support family attenuates relationship severity pds final model accounted variance pds scores large effect size study first demonstrate interrelationships income social support resilience postpartum psychopathology childhood trauma surviving women social support appeared protect pds mothers study income conferred protective effect accompanied family support clinicians implies need focus improving family relationships especially risk mothers
background genome wide association studies identified several common risk loci schizophrenia scz parallel neuroimaging studies shown consistent findings widespread white matter disconnectivity patients scz methods examined role genes brain connectivity patients scz combining transcriptional profiles scz risk genes identified recent genome wide association study schizophrenia working group psychiatric genomics consortium data macroscale connectivity reductions patients scz expression profiles psychiatric genomics consortium scz risk genes extracted allen human brain atlas average profile across cortex correlated pattern cortical disconnectivity derived diffusion weighted magnetic resonance imaging data patients scz matched healthy controls results expression profile scz risk genes across cortical regions significantly correlated regional macroscale disconnectivity addition effects found potentially specific scz transcriptional profiles related cortical disconnectivity patients bipolar disorder diffusion weighted magnetic resonance imaging data patients controls examination correlations across genes present allen human brain atlas showed set top strongest correlating genes display significant enrichment disorder potentially identifying new genes involved pathophysiology scz conclusions results suggest disease conditions cortical areas pronounced expression risk genes implicated scz form central areas white matter disconnectivity
background recent introduction computer aided design computer aided manufacturing cad cam monolithic zirconia dental prostheses raises issue material low thermal degradation ltd wellknown problem zirconia hip prostheses phenomenon could accentuated masticatory mechanical stress zirconia ltd process studied vitro work introduces original protocol evaluate ltd process monolithic zirconia prostheses oral environment study general clinical behavior notably terms wear methods design posterior monolithic zirconia tooth elements molars premolars included year prospective clinical trial element several areas molars premolars determined restoration surface areas submitted non submitted mastication mechanical stress glazed non glazed prosthesis placement vivo analyses regarding ltd wear performed using raman spectroscopy sem imagery laser profilometry placement restorations clinically evaluated following criteria world dental federation fdi complemented analysis fracture clinical risk factors two independent examiners perform evaluations clinical evaluation vivo analyses carried months year years discussion clinicians patients results trial justify use monolithic zirconia restorations dental practice researchers originality clinical study including vivo analyses material aging provide important data regarding zirconia properties authors published elsevier inc open access article license
mixed method study examined factors associated parents attending child mental health treatment initially seeking help year old child part larger study comparing two evidence based treatments among low income racial ethnic minority families seeking child mental health services parents initiated mental health treatment african american multi racial low income never attended child first treatment session socio demographic characteristics parenting stress depression severity child behavior problems length treatment delay intake first scheduled treatment session compared families attend first treatment session parents never attended child first treatment session likely live four adults children depressive symptoms median length treatment delay days iqr attended days iqr attend child first treatment session three themes emerged caregiver interviews expectations treatment delays getting help ambivalence research participation findings suggest need develop better strategies addressing risk factors early treatment process reducing length time families adverse psychosocial circumstances must wait child mental health treatment
widely accepted evolution building information modeling bim increasingly affecting roles construction management professionals architecture engineering construction aec industry teaching bim construction engineering project management cepm curricula requires emphasis learning bim process improvement methodology rather technology paper describes experiences university course building information modeling developed educate next generation construction managers understand bim effectively use existing bim plan execution construction projects project based course students gain knowledge implementation bim concepts throughout lifecycle project findings lessons learned teaching experience seven offerings course documented
introduction malignancies reported patients rheumatoid arthritis psoriatic arthritis ankylosing spondylitis treated anti tumour necrosis factor anti tnf agents areas covered conducted systematic review randomized controlled trials rcts determine effect anti tnf agents occurrence cancer type literature databases searched may identify relevant studies evaluated adalimumab certolizumab etanercept golimumab infliximab compared placebo treatment data cancer occurrence extracted maximum follow time reported expert opinion fifty five rcts patients met eligibility criteria trials patients reported least one case cancer total malignancies degree variability studies consistent would expected occur chance alone evidence association anti tnf agents cancer risk fixed effects model random effects model found evidence selective outcome reporting publication bias suggesting pooled effect estimate cancer may overestimated evidence imprecise risk bias high unclear across primary studies
context software engineering ubiquitous systems experienced important rapid growth however vast research corpus makes difficult obtain valuable information objective identify evaluate synthesize research relevant approaches addressing different phases software development life cycle ubiquitous systems method conducted systematic literature review papers presenting evaluating approaches different phases software development life cycle ubiquitous systems approaches classified according phase development cycle addressed identifying main concerns limitations results identified papers reporting approaches addressing issues related different phases software development cycle ubiquitous systems approaches aimed addressing implementation evolution maintenance feedback phases others phases testing need attention researchers conclusion recommend follow existing guidelines conducting case studies make studies reproducible closer real life cases phases development cycle extensively explored still room research phases toward agile integrated cycle requirements testing feedback elsevier inc rights reserved
mhealth programs offer potential practical cost effective delivery interventions capable reaching many individuals compare effectiveness mhealth interventions promote physical activity reduce sedentary behavior free living young people adults comparator exposed usual care minimal intervention determine whether extent interventions affect levels use taxonomy behavior change techniques bcts describe intervention characteristics systematic review meta analysis following prisma guidelines undertaken identify randomized controlled trials rcts comparing mhealth interventions usual minimal care among individuals free conditions could limit total moderate vigorous intensity physical activity mvpa walking outcomes extracted intervention content independently coded following item taxonomy bcts twenty one rcts participants objectively measured met eligibility criteria decreased following mhealth interventions usual care standardised mean difference smd confidence interval summary effects across studies small moderate non significant total smd mvpa smd walking smd bcts employed frequently intervention mean range comparator conditions mean range bcts employed intervention conditions current mhealth interventions small effects technological advancements enable comprehensive interactive responsive intervention delivery future mhealth studies ensure active ingredients intervention reported sufficient detail
objective recent literature underlines relationship alexithymia dysfunctional patterns affective involvement family demonstrating early caregiver sensitivity responsiveness child emotions important determinants regulation distressing emotions relationships others purposes study following investigate relation parenting alexithymia adult attachment styles measure predictive variables adult attachment related anxiety avoidance method participants students group high school students group university students participants completed parental bonding instrument toronto alexithymia scale experience close relationships results conclusions male group parental control seems influence almost alexithymia subscales although maternal care paternal control affect tendency externally oriented thinking female group alexithymia dimensions seem influenced parenting except father control results consistent hypothesis alexithymia could develop response interactions primary caregivers could also influence infant adult attachment
optimal control fractional order active isolation system researched based optimal control theory effect fractional order derivative passive isolation system also analyzed mechanical model established viscoelastic features isolation materials described fractional order derivative viscoelastic property fractional order derivative dynamical system studied fractional order derivative could divided linear stiffness linear damping found fractional coefficient fractional order could affect resonance amplitude equivalent linear damping coefficient also resonance frequency equivalent linear stiffness based optimal control theory feedback gain fractional order active isolation system harmonic excitation obtained changed excitation frequency statistical responses displacement velocity passive active vibration isolation systems subjected random excitation also presented verifies excellent performance fractional order derivative vibration control engineering
purpose review prevalence severity ige mediated food allergy increased dramatically last years becoming global health problem multiple lines evidence suggest epigenetic modifications genome resulting gene environment interactions key role increased prevalence atopic disease review describe recent evidence suggesting epigenetic changes mediate susceptibility food allergies discuss immunotherapy may reverse effects discuss areas epigenome yet unexplored terms food allergy histone modification chromatin accessibility new techniques may utilized future studies recent findings recent findings provide strong evidence dna methylation certain promoter regions forkhead box protein associated clinical reactivity changed treatment reports epigenetic changes limited also show evidence significant change based disease status treatment summary comparison epigenetic studies focusing asthma allergic rhinitis food allergy remains understudied however within next decade likely epigenetic modifications may used biomarkers aid diagnosis treatment food allergic patients dna methylation specific loci shown associations food challenge outcomes successful desensitization treatment overall phenotype compared healthy controls
paper new system presented manage elevator operations socket established connect adam module calling elevator requesting destination floor technique provide feedback elevator door status current floor situations make robot losing way destination computer vision utilized identify current floor special situation human obstacle robot camera floor number indicator difficult light conditions etc robot fails detect current floor number height measurements used addition lpshb pressure sensor stml microcontroller height measurements system hardware platform configured programmed sense environment detect current floor number ultrasonic sensor used recognize elevator door status two methods applied handle pressure variations smoothing filter used handle small variation pressure sensor output practical analysis performed choose filter parameter balancing required time pressure reading stability adaptive calibration method used calibrate sensor readings robot current floor entering elevator overcome wide range variation daily pressure earlier developed localization method multi floor environment utilized identify robot current floor number outside elevator developed method integrated real laboratory mobile robot transportation system numerous experiments implemented different floors typical life sciences building find average tolerance pressure different floors obtaining daily variation pressure sensor finally validating proposed elevator operation management system based mobile robot validation experiments prove efficient performance presented system
owing limitation fossil fuels high consumption pollution transportation vehicle industry looking sources energy fuel cell hybrid electric vehicle fchev could suitable solution considering state art main components paper presents simulation powertrains fchevs order dimension fuel cell primary source energy investigate power flows motoring recuperative braking purpose matlab simulink model built used wide range applications results simulation show best powertrain configuration two wheeled vehicles three different cases bike traction force provided electric motor pedaling cyclist bike traction force provided electric motor without pedaling motorcycle passengers specifically consumption state charge soc battery amount energy generated source energy monitored model validation done comparison obtained results scientific articles literature
given set coloured points real line study problem answering range alpha majority heavy hitter queries specifically query range want return colour assigned alpha fraction points contained present new data structure answering range alpha majority queries dynamic set points alpha element data structure uses space supports queries lgn alpha time updates lgn alpha amortized time coordinates points integers query time improved lgn alpha constant values alpha improved query time matches existing lower bound data structure polylogarithmic update time also generalize data structure handle sets points dimensions well dynamic arrays entry colour elsevier rights reserved
objective comparative effectiveness treatment options surgical clipping endovascular coiling unruptured cerebral aneurysms remains issue debate studied clinical trials authors investigated association treatment method unruptured cerebral aneurysms outcomes elderly patients methods authors performed cohort study medicare fee service claims data elderly patients treatment unruptured cerebral aneurysms control measured confounding authors used propensity score conditioning inverse probability weighting mixed effects account clustering level hospital referral region hrr instrumental variable regional rates coiling analysis used control unmeasured confounding create pseudo randomization treatment method results study period patients underwent treatment unruptured cerebral aneurysms met study inclusion criteria patients surgical clipping endovascular coiling instrumental variable analysis demonstrated difference coiling clipping year postoperative mortality day readmission rate however clipping associated greater likelihood discharge rehabilitation days longer length stay los associations present propensity score adjusted inverse probability weighted models conclusions cohort medicare patients difference mortality readmission rate clipping coiling unruptured cerebral aneurysms clipping associated higher rate discharge rehabilitation facility longer los
proactive computing systems act eliminate mitigate take advantage previous knowledge manipulate situations interest advance behavior critical ambient assisted living systems paper present semantic models design implement proactive systems home care environments implemented devices sensors models support semantic interoperability physical environments different software levels allowing identification user context proactivity obtained construction suitable action plan results consumption services provided devices services one challenge model high level situation select particular device best meets users needs considering context location disabilities paper describes steps required create generic flexible modularized model extended incorporate new domain knowledge regarding specific requirements different ambient assisted living systems
principle equivalence shown extend situations involving radiation reaction example lorentz force law governs motion isolated charge undergoing radiation reaction case isolated uncharged particle small mass geodesic equation governs motion even radiation reaction included local observer understand motion must subtract singular field particle actual electromagnetic gravitational fields measures remaining source free fields used computing motion particle local measurements observer knowledge existence radiation sees effect would compelled describe radiation reaction
ultrafine phase change fibers pcfs core sheath structure based polyethylene glycol cellulose acetate peg blends fabricated successfully via coaxial electrospinning thermal energy storage sem tem images show cylindrical smooth phase change fibers obtained peg phase change ingredient encapsulated completely sheath morphology composite fibers thermal treatment indicates prepared fibers form stable phase change materials pcms results dsc demonstrate composite fibers impart balanced reversible phase change behaviors phase transition enthalpies composite fibers increase increasing peg content fibers phase transition temperatures fibers similar pure peg stress strain curves show ultimate strength ultimate strain composite fibers lower fibers decrease increase peg content peg composite fibers extensive applications smart material thermal energy storage temperature regulation elsevier ltd rights reserved
new class soft matter actuator liquid crystal elastomer lce shows promise application wide variety mechanical microsystems frequently referred artificial muscle family materials exhibits large actuation stroke generates considerable force compact form may easily combined structures devices commonly used microsystems mems show standard microfabrication techniques may used integrate lces mechanical microsystems present depth analysis mechanical actuation properties using example micro optics optical mems demonstrate performance flexibility allows realization entirely new types tunable optical functionality
ongoing trend towards multi site software development brings benefits also creates additional challenges regarding remote communication coordination software engineering ontology ontology first developed clarify software engineering concepts project information enable knowledge sharing among dispersed teams however current ontology passive structure ontologies exist web passive structure refers need know exactly concepts relationships users referring ontology otherwise may able obtain knowledge required needed active support help users find information need provide meaningful output paper propose active software engineering ontology multi agent system seomas framework intended provide active support access software engineering domain knowledge recommend software project information captured ontology uml agent uml used formalise seomas framework model interactions various agents prototype developed evaluated using several scenarios online shopping system development case study
vascular dementia vad second common cause dementia occurs cerebral blood supply reduced disarrangement circulatory system environmental enrichment associated cognitive improvement motor function recovery anxiety relief respect various neurodegenerative diseases emotional stress models purpose study determine whether long term influenced cognitive impairment rat model chronic hypoperfusion induced permanent occlusion bilateral common carotid arteries bccao maze morris water maze tests performed evaluate rats cognitive functions also protein expression brain derived neurotrophic factor bdnf phosphorylated camp calcium response element binding protein pcreb vascular endothelial growth factor vegf confirmed western blot microvessels angiogenesis associated proteins hippocampal region investigated using immunohistochemistry vad group showed significantly better cognitive functions vad group maze mwm tests addition vad group showed significantly increased expression bdnf pcreb vegf hippocampus compared vad group rats vad group also increased length microvessels vegf expression hippocampus results suggest long term exerts neuroprotective effects cognitive impairment induced chronic cerebral hypoperfusion enhancement bdnf pcreb vegf expression indicate may good nursing intervention vascular dementia patients
present paper details development cost effective fall detection intervention system fadis based wireless sensor network technologies system designed integrate existing low tech homes enable ambient assisted living environments software hardware devices attempt facilitate safe proactive independent living fadis designed operate add component existing centralized solutions complete otherwise integral yet independent component decentralized scalable expandable solutions accordingly fadis implemented two parts part developed scaled proof concept served foundation part principal focus paper part fadis developed fully operational real scale system uses self healing mesh network protocol beaglebone black development platform serves sink node two class degrees line lasers used conjunction light dependent resistors gauge probabilities emergency event based estimated dimensions collapsed object parts fadis construes probabilities emergency event high series corresponding robotic response actions intervene locally automated notifications sent emergency personnel care takers family members via wireless cellular technologies series sample runs detailed described present work order demonstrate argue feasibility functionality fadis fall detection intervention system particular wsn based system general elsevier rights reserved
paper describes analysis project irma inter countries research manufacturing advancement results lithuania research focused specific field manufacturing engineering swot analysis lithuania manufacturing sector provided connection manufacturing engineering higher technical education lithuania considered
paper presents three phase transformerless uninterruptible power supply ups sinusoidal pulse width modulation spwm based division summation sigma digital control transformerless ups controls power flow link utility grid well tracks reference voltage proposed control law derived sigma digital approach takes account effects link voltage fluctuation grid voltage distortion inductance variation due different current levels thus distortion input current filter inductor core size reduced significantly however circulating current may flow common ground input power factor corrector pfc output three phase four wire inverter derived control law based spwm suppress circulating current regulate output voltages tightly experimental results measured three phase transformerless ups confirmed analysis discussion proposed control approach
dealing component interactions dependencies remains core fundamental aspect engineering conflicts constraints solved almost daily basis failure consider interactions dependencies lead costly overruns failure meet requirements lengthy redesigns thus management monitoring dependencies remains crucial activity engineering projects becoming ever challenging increase number components component interactions component dependencies structural functional sense reasons tools methods support identification monitoring component interactions dependencies continues active area research particular design structure matrices dsms extensively applied identify visualize product organizational architectures across number engineering disciplines however process generating dsms primarily used surveys structured interviews meetings engineers consequence high cost associated engineers time alongside requirement continually update dsm structure product develops follows proposition paper investigate whether automated continuously evolving dsm generated monitoring changes digital models represent product includes models generated computer aided design finite element analysis computational fluid dynamics systems paper shows dsm generated changes product models corroborates product architecture defined engineers results previous dsm studies addition levels product architecture dependency also identified particular affordance automatically generating dsms ability continually generate dsms throughout project paper demonstrates opportunity project managers monitor emerging product dependencies alongside changes modes working engineers application technique could used support existing product life cycle change management solutions cross company product development small medium enterprises product life cycle management solution
aim identify clinical features latent polycythemia vera independent nosological entity subjects methods investigation enrolled patients extensive manifest latent visited outpatient department hematology research center ministry health russia october results gender distribution patients statistically comparable analyzed groups patients manifest slightly older latent median age compared groups years respectively red blood cell counts hemoglobin concentrations packed cell volume higher patients manifest blood platelet counts higher latent group differences number white blood cells compared groups patients jak mutation carriers jak allele load significantly higher manifest group latent group compared patient groups differed rate thromboses history diagnosis patients latent thromboses detected cases versus manifest latent mainly venous thromboses abdominal vascular thromboses diagnosed high frequency arterial thromboses revealed cases conclusion chronic myeloproliferative disease characterized jak mutation borderline hemoglobin counts morphological features bone marrow trephine biopsy specimen specific independent variant namely latent
circadian rhythms near cycles number physiological behavioural parameters underpinning circadian timing systems one key homeostatic regulatory systems mammalian physiology many common psychiatric conditions associated disrupted sleep including common occurrence delayed advanced phase sleep syndromes may indicative dysregulated circadian timing disorders article discuss evidence abnormal circadian rhythms seasonal affective disorder bipolar disorder attention deficit hyperactivity disorder much evidence suggest conditions associated either phase delays phase advances core phase markers circadian clock melatonin core body temperature suggesting presence circadian desynchrony conditions also highlight findings pharmacological behavioural interventions ameliorate circadian misalignments efficacious producing symptomatic relief suggesting intrinsic link circadian affective systems manipulated clinical benefit
abnormal accumulation tdp cytoplasmic nuclear inclusions accompanying nuclear clearance common pathology initially identified amyotrophic lateral sclerosis als frontotemporal dementia ftd also found alzheimer disease tdp serves splicing repressor non conserved cryptic exons function compromised brains als ftd patients suggesting nuclear clearance tdp underlies inability repress cryptic exons however whether tdp cytoplasmic aggregates prerequisite incorporation cryptic exons known assessed hippocampal tissues human postmortem brains including cases confirmed diagnosis neuropathologic changes along age matched controls found cryptic exon incorporation occurred cases exhibiting tdp pathology furthermore incorporation cryptic exons observed hippocampus tdp inclusions restricted amygdala earliest stage tdp progression importantly cryptic exon incorporation could detected brains lacking tdp inclusion exhibiting nuclear clearance tdp data supports notion functional consequence nuclear depletion tdp determined cryptic exon incorporation likely occurs early event tdp proteinopathy may greater contribution pathogenesis currently appreciated early detection effective repression cryptic exons patients may offer important diagnostic therapeutic implications devastating illness elderly
objective osteopenia chronic bone condition characterized decreased calcification density bone mass untreated lead osteoporosis bone fractures although increasing prevalence nowadays osteopenia adequately prevented managed study evaluated efficacy term changes bone density safety oral formulation based turmeric phytosome meriva subjects suffering low bone density patients methods otherwise healthy subjects low bone density enrolled pilot supplement study informed participants freely decided follow either standard management control low bone density control group associated curcumin based oral supplementation supplement group bone densities heel small finger upper jaw evaluated inclusion different time points observational period weeks subjects results bone density heel measured sahara densitometer remarkably improved meriva supplemented group significant decrease ultrasounds transmission values week week compared baseline values bone densities small finger upper jaw also significantly increased study supplemented subjects reaching respectively week respect values inclusion noteworthy significant changes heel small finger upper jaw densities observed control group last safety tolerability issues reported observational period conclusions preliminary study suggests curcumin based supplementation combination appropriate lifestyle could beneficial prevention management osteopenia
paper presents statistical method analysis wind farm lightning surge transients employs sophisticate wind farm high frequency transients model developed within emtp software package method features monte carlo simulation applied numerical analysis wind farm lightning transients produces statistical depiction overvoltages distribution within wind farm electrical network could used statistical semi statistical methods wind farm equipment insulation coordination could assist wind farm lightning risk management surge protection optimisation wind farm lightning incidence computed aid linet lightning detection network data time accounting actual wind turbine geometry exposure terrain topography orography wind turbine effective height exposed locations determined physical postulates governing initiation lightning subsequently obtained wind farm equipment overvoltages statistically described means kernel density estimation procedure application proposed method actual onshore wind farm provided paper well elsevier ltd rights reserved
paper described hybrid automaton based approach towards development simplified medium voltage direct current mvdc shipboard power system sps model sps considered good subject hybrid modeling hybrid control system design combines variety continuous component dynamics discrete control actions well variety switching components therefore hybrid system model provide accurate effective way simulate system represent combined behaviors sps within hybrid automata model represented paper continuous power system dynamics modeled form differential algebraic equations daes discrete events dynamics represented discrete finite automations dfas simulation results indicate proposed modeling scheme effective suitable particularly system level studies control algorithm design mvdc sps
background open surgical excision trigonum traditional treatment posterior ankle impingement syndrome pais however endoscopic excision recently become quite popular purpose hypothesis purpose study compare results endoscopic versus open excision symptomatic trigonum treatment pais athletic population hypothesized endoscopic technique would superior open technique regarding functional outcomes pain time return training previous sports level study design randomized controlled trial level evidence methods athletes underwent symptomatic trigonum excision athletes open procedure group endoscopic procedure group american orthopaedic foot ankle society aofas hindfoot score visual analog score foot ankle vas obtained time return training previous sports level recorded results patients group appeared significant improvement aofas hindfoot score compared group whereas statistical significance found postoperative vas scores groups mean time return training weeks group weeks group time return previous sports level weeks group weeks group overall complication rate group cases group case conclusion open procedure endoscopic approach yielded acceptable outcomes terms function pain however complication rates remarkably lower endoscopic treatment time return full activities much shorter endoscopic excision trigonum safe effective treatment option athletes require early return previous sports level
paper investigate resource allocation algorithm design multicarrier non orthogonal multiple access noma systems employing full duplex base station serving multiple half duplex downlink uplink users simultaneously proposed algorithm obtained solution non convex optimization problem maximization weighted sum system throughput apply monotonic optimization develop optimal joint power subcarrier allocation policy optimal resource allocation policy serves system performance benchmark due high computational complexity furthermore suboptimal iterative scheme based successive convex approximation proposed strike balance computational complexity optimality simulation results reveal proposed suboptimal algorithm achieves close optimal performance addition noma systems employing proposed resource allocation algorithms provide substantial system throughput improvement compared conventional multicarrier orthogonal multiple access oma systems baseline schemes addition results unveil noma systems enable fairer resource allocation compared traditional oma systems
prototype line rotor temperature monitor based phosphor decay time measurements using optical fibers tested two large electrical generators
paper presents hybrid cascode compensation current amplifiers hccca nano scale area efficient three stage amplifiers driving ultra large capacitive loads total compensation capacitor split placed among two high speed feedback loops unique current amplifier using hccca load dependent non dominant poles pushed much higher frequencies thereby achieving improved performance especially heavy capacitive loads employed current amplifiers make possible significantly reduce physical size compensation capacitors save silicon area effectiveness proposed technique verified cmos process hccca amplifier prototype designed drive load capacitor using compensation capacitor achieves mhz gain bandwidth product slew rate consuming power supply achieved large signal small signal performance metrics superior topologies reported literature
present study microbial cellulose carbohydrate polymer made conductive oxidative polymerization aniline sulfate reducing bacteria srb immobilized surface conductive biopolymer used biocathode bioreduction process reduce model heavy metals results fourier transform infrared analysis confirmed polyaniline distributed cellulose surface maximum tensile stress conductive biopolymer obtained mpa using calculating young modulus current density determined optimal increase significantly reduced required time reduction system reached removal within kinetic experiment studies showed high constant rate mean obs results showed conductive used appropriate bioelectrode reduce bioelectrochemical processes expected experimental results could used reference utilization bioelectrochemical systems published elsevier ltd
aim study presented paper development labor consumption measurement system based real time tracking technology use dam construction site technology includes global positioning system gps geographic information system gis system three layered aims solve several labor computational usability challenges software processing collected data presenting real time site state visualization accurate analysis site labor consumption run smart phones gps devices site private wireless base stations servers benefits quantitative labor consumption measurement approach hydropower projects include provision dam monolith precise information regarding number category laborers together respective working hours knowledge provides adequate quality management information owner supervisor importantly aids payment negotiations contractors proposed system firstly applied world third largest hydropower project site tests successfully demonstrated feasibility effectiveness whole system results achieved show system able log entire site trajectories laborers calculate accurate labor consumption dam monolith elsevier rights reserved
paper new inverting non inverting type current mode first order pass phase shifter presented proposed configuration composed two current controlled current follower transconductance amplifiers cccftas three passive elements considering electronically tunability properties cccftas phase responses proposed circuit controlled external bias current circuit cascadable current mode suitable wideband applications active passive sensitivities low theoretical results verified pspice simulations using bjt realization cccfta
past decades traditional rdbms reiational database management systems predominant technology used storing retrieving structured data web business applications since however relational databases started squandering importance due strict schema reliance costly infrastructure collectively led problem upgrade hardware software challenges relationships objects another major issue failure brobdingnagian hike bigdata new database model called nosql plays vital role bigdata analytics main focus paper four different types nosql databases owned social networking sites like facebook linkedin twitter myspace foursquare flickr friendfeed main features four types nosql databases like scalability data model concurrency control consistency storage availability partitioning durability transactions implementation language query support possibilities programming characteristics compared analyzed features compared sub categories four nosql databases swift querying social networking sites detailed analysis presented features like data storage fast retrieval phase query processing given primary importance also present comparison time taken insert read operations social network data facebook associating friends intimate friends family groups like hometown workplace results compared suitable database nosql graph database subcategories insert read operations facebook identified
emerging evidence suggested genetic factor attributed major determinant complex pathogenic mechanism gestational diabetes mellitus gdm related genetic study limited aimed investigate impact polymorphisms mirna binding sites mir binding snps risk gdm chinese han pregnant women screened gdm susceptibility genes extensively selected mir binding snps using four bioinformatics software taqman allelic discrimination assays applied mir binding snps genotyping gdm patients controls total five potential mir binding snps slca insr insr kcnj kcnq selected results showed slca insr increased risk gdm adjusting age additive model furthermore found significantly associate higher levels fasting plasma glucose dom dom ogtt plasma glucose dom dom lower fasting insulin concentrations rec rec decreased homa rec rec additionally correlation ogtt plasma glucose dom dom observed two mir binding snps slca insr increased gdm susceptibility functional studies required confirm underlying mechanism study provided additional insights genetic pathogenesis gdm
duty cycled medium access control mac protocols certainly improve energy efficiency wireless networks however protocols still suffer severe degrees overhearing idle listening two issues prevent optimum energy usage crucial aspect energy constrained wireless networks wireless sensor networks wsns wake radio wur systems drastically reduce problems completely switching nodes microcontroller unit mcu main radio transceiver secondary extremely low power receiver triggered particular wireless transmission called wake call unfortunately wur studies focus theoretical platforms custom built simulators factors reduce associated usefulness obtained results paper model simulate real recent promising wur hardware platform developed authors simulation model uses time energy consumption values obtained laboratory rely custom built simulation engines rather omnet simulator performance wur platform compared four well known widely employed mac protocols wsn three real world network deployments paper demonstrates use wur platform presents numerous benefits several areas energy efficiency latency packet delivery ratio applicability provides essential information serious consideration switching duty cycled mac based networks wur
intrusion detection systems ids one primary components keeping network secure classified different forms based nature functionality host based ids network based ids anomaly based ids however literature survey portrays different evasion techniques ids thus always important study responsive behavior ids failures state art shows much work done ids contrary little intrusion response system irs paper propose model irs based inspiration derived functioning defense response mechanism plants proposed model first attempt kind objective develop efficient response mechanism network subsequent failure ids adopting plants source inspiration
wind power generation electricity gained popular support low environmental impact low costs relative renewable energy sources however concerns raised power sector wind power generation come price increased damage power generators wind power generation naturally volatile requires power sources start shut accordance weather conditions instance coal gas generators general built previous literature used simulations show damage done associated costs substantial use dataset containing reported failures nordic electricity market nord pool data danish wind power generation analysis shows denmark rest nord pool short term costs associated volatility wind power generation non significant elsevier ltd rights reserved
relationship adolescents communication significant others mother father best friend quality life kidscreen investigated scottish adolescent pet owners variable attachment pets also tested assessed mediator relationship positive relationship adolescents communication significant mother father best friend quality life decreased controlling attachment dogs cat owners positive relationship communication best friend quality life decreased controlling attachment cats cat dog owners attachment pets predicted higher levels quality life higher attachment dogs cats explained good best friend attachment pets best friends mediation effects attachment dogs cats might explained terms caring activities associated types pets
amount physical pressure plays important role complex decongestive therapy cdt function pressure microcirculation takes place blood vessels tissue part total lymphatic system lymphatic vessels transport lymphatic load interstitial space blood stream lymphatic vessel system characterized specific anatomical conditions like initial lymphatic vessels precollectors collectors lymphatic strains therapeutic target complex decongestive therapy components cdt include manual lymphatic drainage compression therapy decongestive kinesitherapy good skin care increase transport capacity lymphatic vessel system currently cdt acknowledged main conservative treatment lymphedema primary secondary genesis lipolymphedema phlebolymphedema clinical practice increasingly confronted edema multifactorial genesis requiring critical discussion stocktaking comprehensive clinical findings terms indication cdt therapeutic success depends joint application cdt components patient compliance increasing extent medical research tries combine successfully cdt adjunct treatment options
flexible mnemonic mechanisms adjust different internal mental states provide major adaptive advantage however little known regarding flexibility achieved human brain examined brain activity retrieval false memories movie generated exposing participants misleading information half participants suspected memory manipulation distrustful whereas half naive distrustful displayed accurate memory performance brain signature different naive distrustful ability differentiate true false information driven qualitatively distinct hippocampal activity endorsed items consistent view hippocampal encoding allows recollection specific source conversely naive bold differences true false memories linearly correlated accuracy across participants suggesting naive subjects needed reinstate evaluate stored information discern true false propose results lend support models suggesting hippocampal activity exhibit different computational schemes depending memorandum attributes furthermore show trust considered subjective state mind may alter basic hippocampal strategies influencing ability separate real false memory wiley periodicals inc
physical activity practice positive effect children health development however studies investigated relationship extracurricular sports psychomotor development spanish preschoolers study aims compare psychomotor development among preschoolers years participating regular sports practice participating nde study carried using quantitative methodology cross sectional design participants preschoolers mean age years girls participants responded hoc questionnaire physical habits sociodemographic variables psychomotor development evaluated eod results show sample practiced extracurricular physical activity gender differences found student test showed group better psychomotor development nde children regarding gender differences boys practiced extracurricular sports showed better psychomotor development boys result girls furthermore extracurricular sports participation significantly lower among children lower psychomotor development study provides new findings relationship psychomotor development extracurricular sport practice spanish preschoolers physical activity sports practice improve children psychomotor development results obtained confirm necessity improving physical activity sports programs since early ages
apophysomyces rare fungal organism causing rhino orbito cerebral mycotic infections high morbidity mortality typically immunocompetent individuals several cases apophysomyces elegans orbital disease reported herein report case apophysomyces variabilis infection involving orbit sinuses calvarium immunocompetent year old woman review literature unlike prior cases elegans classic rhino orbito cerebral infection case included diffuse calvarial lytic lesions overlying soft tissue nodules without parenchymal intracranial involvement radiographic clinical evidence infarction orbital contents cavernous sinus thrombosis anastomoses superior orbital ophthalmic vein diploic veins calvarium believed primarily responsible unusual mode spread extradural surface brain although patient stabilized without definitive surgical intervention disease slowly intermittently progressed year presentation requiring multiple courses antifungal treatment elsevier inc rights reserved
investigated illusory recollection dividing lists associated words three subsets high medium low based backward associative strength bas unstudied theme participants studied subsets different visual locations computer screen afterwards given source memory test experiment varied order high medium bas subsets studied experiment manipulated study order well associative strength medium bas subsets strong weak across experiments illusory recollection constrained study order bas source attributions high bas location likely source strength effect high bas items studied first studied following items relatively low associative strength however attributions strong medium bas studied location likely items studied high bas items findings interpreted resulting misbinding source details encoding explained activation monitoring theory illusory recollection
acetabular dysplasia known cause hip osteoarthritis addition abnormal anatomy changes kinematics joint reaction forces jrfs muscle forces could cause tissue damage cartilage labrum may contribute pain fatigue objective study compare lower extremity joint angles moments hip jrfs muscle forces gait patients symptomatic acetabular dysplasia healthy controls marker trajectories ground reaction forces measured dysplasia patients typically developing control subjects musculoskeletal model scaled opensim subject subject specific hip joint centers determined using reconstructions images joint kinematics moments calculated using inverse kinematics inverse dynamics respectively muscle forces hip jrfs estimated static optimization inter group differences tested statistical significance results demonstrated dysplasia patients higher medially directed jrfs joint angles moments mostly similar groups large inter group effect sizes suggested restriction range motion patients hip ankle higher medially directed jrfs inter group differences hip muscle forces likely stem lateralization hip joint center dysplastic patients joint force differences combined reductions range motion hip ankle may also indicate compensatory strategies patients dysplasia maintain joint stability elsevier ltd rights reserved
hydrogen one important energy sources future well least harmful form energy environment hydrogen clean renewable energy supply used non toxic energy storage transport medium electrolysis water high power dissipation value important problem systems several internal external variables influence electrical behavior electrolysis cells efficiency namely nature concentration purity electrolyte electrodes type form cell temperature pressure etc paper presents experimental study regarding hydrogen production water electrolysis using photovoltaic panel current study consists seeing effect electrolyte nature volume hydrogen produced experiments conducted ouargla university including comparison two alkaline electrolytes behaviors show potassium hydroxide koh effective sodium hydroxide naoh electrolysis conditions pressure temperature load current load voltage overall production koh naoh cells hydrogen standard conditions recording maximum efficiencies respectively
decades vitamin antagonists vkas oral treatment choice many thromboembolic conditions limitations vkas include need monitoring blood testing drug interactions narrow therapeutic windows shortcomings led development direct oral anticoagulants new oral agents act specific targets coagulation cascade factor thrombin negate shortcomings vkas article reviews roles dabigatran rivaroxaban apixaban edoxaban stroke prevention nonvalvular atrial fibrillation prevention venous thromboembolism orthopedic surgery treatment venous thromboembolism direct oral anticoagulants least efficacious safe traditional anticoagulation therapy
cooperative behavior widespread among animals yet neural mechanisms studied detail examined cooperative territory defense behavior associated neural activity candidate forebrain regions cichlid fish astatotilapia burtoni find territorial male neighbor engage territory defense dependent perceived threat intruder resident male hand engages defense based size behavior partner neighbor neighbor find index engagement correlates neural activity putative homolog mammalian basolateral amygdala preoptic area well preoptic dopaminergic neurons resident neighbor behavior correlated neural activity homolog mammalian hippocampus overall find distinct neural activity patterns neighbor resident suggesting individual perceives processes intruder challenge differently cooperative territory defense depending behavioral role elsevier inc rights reserved
generalized bilinear operators based prime number hirota satsuma like equation proposed rational solutions generated graphically described using symbolic computation software maple elsevier ltd rights reserved
today buildings energy consumption considerable amount whole therefore optimizing energy buildings leads noticeable decrease total energy consumption world energy efficient buildings developed carrying great research effort control procedures serve privileged method help new buildings comply optimal system energy consumer thus meet nearly zero energy purpose paper present method controlling building temperature simultaneously reducing cost providing hybrid heating systems sufficient energy investigating room tehran city day example methods model predictive control mpc economic optimization mpc consecutively mpc without economic optimization proportional integral derivative pid controller optimized genetic algorithm presence gas thermal source pid controller optimized presence electric thermal source pid controller optimized multi objective presence two gas electric thermal sources designed implemented research furthermore effect methods cost reduction temperature regulation inside room studied eventually specified using mpc method economical optimization highest influence cost reduction keeps temperature inside room predefined range method achieved cost saving compared mpc main targets study regulating inside temperature cost optimization according main targets study using mpc methods without economical optimization multi objective genetic algorithm would effective elsevier rights reserved
paper describes laboratory testing investigate suitability recycled construction demolition materials alternative subbase materials permeable pavements permeable pavements increasingly used urban stormwater management systems three commonly found recycled waste materials crushed brick recycled concrete aggregate rca reclaimed asphalt pavement rap investigated assess suitability permeable pavement subbase materials geotextile also used research trap pollutants laboratory tests included basic physical characterization particle size distribution specific gravity water absorption los angeles abrasion california bearing ratio cbr modified proctor compaction tests addition hydraulic conductivity tests undertaken laboratory test setup different influent suspension percentages moisture contents temporal variations effluent suspension percentages investigated assess clogging effects found geotextile layer effect terms permeability materials chemical assessment included organic content value trace element leachate concentration range contaminant constituents compared maximum allowable limits soil natural water well environmental protection authorities requirements terms geotechnical chemical assessment permeable pavement applications rca found suitable alternative construction material permeable pavements borderline rap meet specified requirements american society civil engineers
transparent plates organic glass plastic plate widely used construction industry high tech products scientific research applications parallelism uniformity measurement manufacture quality control become inevitable interferometer label free high precision high efficient device used many fields according single element interferometer demonstrate measurement parallelism uniformity transparent medium beam splitter cube key component half plane wave laser source passes measured medium remaining half directly passes air two halves different optical paths meet beam splitter cube parallelism uniformity determined calculating interference fringe shift number rotating measured sample coherent beam divided two parts beam splitter one passes lens arrives photoelectric counter arrives observation plane charge coupled device photoelectric counter used count integer part fringe shift number rotating sample decimal part detected calculating phase difference two interferograms captured rotation measurement principle proposed device analyzed detail numerical simulations fringe shift number gray level changing sample rotation angle thickness refractive index sample carried simulation results show bigger rotation angle thickness refractive index sample greater fringe shift number therefore measurement accuracy improved increasing rotation angle thickness sample addition also simulate measurement processes two kinds samples unparallel inhomogeneous transparent plates simulation results prove feasibility high accuracy proposed method finally optical experiment conducted demonstrate practicability present device parallelism cuvette used one year tested device results show difference thickness cuvettes micron scale peak valley value root mean square rms value difference contrast test results results proposed method small value rms value stability repeatability proposed setup tested experimental condition mean value standard deviation fringe shift number min respectively results testify high accuracy stability method conclusion performance measurement method demonstrated numerical simulation optical experiment
recent years researchers field structural health monitoring rigorously striving replace conventional nondestructive evaluation techniques smart material based structural health monitoring techniques techniques possess distinct advantages conventional techniques capable providing autonomous real time reliable cost efficient monitoring instance electromechanical impedance technique employing smart piezo impedance transducer lead zirconate titanate known sensitivity detecting damage admittance signatures electromechanical impedance technique structural health monitoring susceptible variation static load applied host structure ignored article presents series experimental analytical numerical studies conducted investigate effect varying axial load presence fixed boundary condition admittance signatures theoretically extensional vibration affected static axial load acting direction however useful identifying effect stiffening caused boundary condition upon increase axial force contributes discrepancy experiments analytical models study suggests effect boundary condition substantial carefully considered real life application electromechanical impedance technique structural health monitoring
india second populous country world million people sixth world population containing world population spite cafeteria choice various contraceptives types media campaigns population control remains distant dream achieve early pregnancies many frequent pregnancies important risk factors maternal child mortality therefore knowledge contraception use utmost importance birth control proper spacing thereby reducing maternal mortality objectives objectives study assess awareness practices contraception among married women identify barriers use contraception materials methods cross sectional study design used interview one hundred married women reproductive age years study conducted santa cruz field practice area goa medical college bambolim predesigned questionnaire comprised various questions awareness practices barriers contraception use utilized data collection data compiled analysed spss software results overall contraception use never used contraceptives past subjects aware condoms oral pills cut sterilization injectable contraceptives around subjects gathered information health professional regarding contraception around subjects using barrier methods prevent conception preference male child religious beliefs family objections ignorance uncooperative husband reasons practicing contraceptive methods conclusions study highlights underutilization contraceptive methods available modern women spite contraceptives freely available market remains small section women still ignorant availability male predominance decision making clearly demonstrated major determinant use contraceptive methods
introduction considering estradiol polyunsaturated fatty acids pufas roles neurogenesis neurotransmission examined whether association pufas incident depressive symptoms postmenopausal women modified hormone therapy use estrogen status methods women free depressive symptoms baseline multi ethnic study atherosclerosis classified usage quartiles dietary eicosapentaenoic acid epa docosahexaenoic acid dha sum epa dha women serum taking antidepressant first function use pufa quartiles second function low status pufa quartiles results among non users positive graded relationships trends found pufas incident depressive symptoms compared lowest quartile adjusted risk ratios rrs highest epa dha epa dha respectively users associations seen analyses run status rrs quartiles pufas positive graded low women null high women conclusions higher intakes dha epa associated higher risk depressive symptoms nonusers contrary hypothesis elsevier ltd rights reserved
nature based approaches flood risk management increasing popularity evidence effectiveness catchment scale spatially distributed upstream measures inconclusive however also remains open question whether certain conditions individual impacts collection flood mitigation interventions could combine produce detrimental effect runoff response modelling framework presented evaluation impacts hillslope channel natural flood management interventions couples existing semidistributed hydrological model new spatially explicit hydraulic channel network routing model model applied assess potential flood mitigation scheme agricultural catchment north yorkshire united kingdom comprising various configurations single variety channel feature hydrological model used generate subsurface surface fluxes flood event network routing model applied evaluate response addition features additional channel floodplain storage approximately seen reduction around peak discharge although might sufficient reduce flooding moderate events inadequate prevent flooding double peaked storm magnitude caused damage within catchment strategies using features specific catchment suggested order improve attenuation could achieved applying nature based approach
sarcopenia considered risk factor osteoporotic fracture major health problem elderly women study aimed investigate association sarcopenia regard muscle mass function prevalent vertebral fracture community dwelling elderly women recruited women aged years korean urban rural elderly cohort study muscle mass function measured using bioimpedance analysis jumping mechanography skeletal muscle index smi jump power used indicator muscle mass function respectively among participants observed vertebral fractures osteoporosis although age body mass index prevalence osteoporosis increased smi jump power decreased prevalence vertebral fracture increased jump power decreased univariate analysis compared highest quartile jump power lowest quartile significant odds ratio vertebral fracture association jump power vertebral fracture remained significant odds ratio even adjusting risk factors including age bone mineral density previous fracture cognitive function contrast association smi vertebral fracture based results low jump power smi associated vertebral fracture community dwelling elderly korean women finding suggests jump power may important role muscle mass osteoporotic fracture
smart grid conceived evolution current electrical grid representing big leap terms efficiency reliability flexibility compared today electrical network achieve goal wireless sensor networks wsns considered scientific engineering community one suitable technologies apply technology due low cost collaborative long standing nature however posed significant challenges utility operators mainly harsh radio propagation conditions lack appropriate systems empower wsn devices making commercial widespread solutions inadequate context main contribution designed comprehensive hoc wsn based solution smart grid sensed focuses specific implementations mac network application layers attain maximum performance successfully deal arising hurdles approach exhaustively evaluated computer simulations mathematical analysis well validation within real test beds deployed controlled environments particular test beds cover two main scenarios found one hand indoor electrical substation environment implemented high voltage laboratory hand outdoor case deployed transmission distribution segment power grid results obtained show sensed performs better suitable smart grid popular zigbee wsn approach
aim evaluate impact postmenopausal osteoporosis thiol disulfide homeostasis materials methods total participants divided two groups group composed healthy postmenopausal women group composed women postmenopausal osteoporosis clinical findings thiol disulfide homeostasis compared two groups results disulfide native thiol ratio group group disulfide native thiol percent ratio significantly higher group adjustment years since menopause age group native thiol total thiol percent ratio significantly lower group adjustment years since menopause age conclusion thiol disulfide homeostasis shifted disulfide side independent age years since menopause postmenopausal osteoporosis
background potent anti inflammatory pharmacologic effects corticosteroids cortisone synthetic derivatives led extensive usage management rheumatologic diseases athletic musculoskeletal injuries efficacy risks locally injected systemically administered corticosteroids treatment athletic injuries unclear objective review critically medical literature determine complications risks associated corticosteroid treatment athletic injuries data sources search databases medline cinahl cochrane clinical trial register performed using ovid interface years search first combined references medical subject headings adrenal cortex hormones glucocorticoids glucocorticoids synthetic second search combined references medical subject headings athletic injuries sprains strains tendon injuries shoulder injuries rotator cuff disease tennis elbow lateral epicondylitis references identified searches intersected limited human produce articles relevant review articles scanned references reviewed additional articles retrieved consideration inclusion study selection inclusion critical review articles must meet following criteria subjects human subjects athletic related injuries subjects received corticosteroid treatment ultimately studies met inclusion criteria data extraction synthesis selected articles categorized whether primary focus usage efficacy corticosteroid injection therapy occurrence complications corticosteroid injection therapy usage complications systemic corticosteroid therapy main results twenty five selected studies primarily examined usage efficacy corticosteroid injections treatment various athletic injuries total subjects received corticosteroid injections among studies minor complications treatment reported eighteen selected studies primarily described complications corticosteroid injections treatment athletic injuries tendon fascial ruptures predominant complications reported search identified articles addressed usage complications systemic corticosteroids treatment athletic injuries although tibial stress fracture multifocal osteonecrosis occurred individuals treated nonathletic injury conditions conclusions critical review reveals existing medical literature provide precise estimates complication rates following therapeutic use injected systemic corticosteroids treatment athletic injuries tendon fascial ruptures often reported complications injected corticosteroids whereas tibial stress fractures multifocal osteonecrosis described systemic corticosteroids
context component based software engineering aimed managing complexity large scale software development composing systems reusable parts understand validate behavior system one needs understand components involved combination understanding configured composed becomes increasingly difficult components implemented various programming languages composition specified external artifacts moreover tooling supports depth system wide analysis heterogeneous systems lacking objective paper contributes method analyze visualize information flow component based system various levels abstraction visualizations designed support comprehension needs safety domain experts software developers respectively certification evolution safety critical cyber physical systems method build system wide dependence graphs use static program slicing determine possible end end information flows across system components define hierarchy five abstractions information flows reduce visual distraction cognitive overload satisfying users information needs improve earlier work provide interconnected views support systematic well opportunistic navigation scenarios results discuss design implementation approach resulting views prototype tool called flowtracker summarize results qualitative evaluation study carried via two rounds interview effectiveness usability views discuss number improvements selective information presentations resulted evaluation conclusion evaluation shows proposed approach views useful understanding validating heterogeneous component based systems address information needs could earlier met manual inspection source code discuss lessons learned directions future work elsevier rights reserved
ambient intelligence ami systems considered promising approach assist people daily life ami proposes development context aware systems equipped devices recognize context act accordingly agents provide effective way develop systems since agents reactive proactive exhibit intelligent autonomous behavior however current agent approaches adequately fulfill requirements posed ami systems modeling point view aim help design providing adequate tools assist development important properties ami systems context awareness implementation point view agent technologies must adapted diversity ami devices communication technologies solution issues propose model driven engineering process supports automatic generation agent based ami systems source metamodel pimagents general purpose agent metamodel adapted support explicit modeling context aware systems target metamodel malaca aspect oriented agent architecture aspect orientation makes malaca platform neutral fipa compliant agent platforms simplifying model driven process solution generates malacatiny agents implementation malaca able run ami devices evaluated convenience applying model driven approach measuring degree automation process evaluated malacatiny mobile phones assessing different parameters related scarcity resources ami systems results obtained satisfactory
investigation paper nonautonomous kadomtsev petviashvili equation fluids plasmas integrability equation examined via painleve analysis multi soliton solutions constructed constraint proposed ensure existence parabola solitons equation based constructed solutions solitonic propagation interaction including elastic interaction inelastic interaction soliton resonance parabola solitons discussed results might useful shallow water wave rogue wave elsevier inc rights reserved
correlational study investigated extended contact strategy improve outgroup attitudes stereotyping prepare children future contact additional aims investigate effects extended contact occur particular intergroup empathy tested mediator direct contact cross group friendship moderator extended contact participants italian immigrant elementary school children results showed extended contact associated improved intergroup empathy turn associated positive outgroup attitudes stereotypes behavioural intentions effects significant among participants low moderate level direct contact theoretical practical implications findings discussed copyright john wiley sons ltd
paper propose simple method perform foreground extraction moving rgbd camera cameras available quite time popularity primarily due low cost ease availability although field foreground extraction background subtraction explored computer vision researchers since long time depth based subtraction relatively new extensively addressed yet current methods make heavy use geometric reconstruction making solutions quite restrictive paper make novel use rgb rgbd data rgb frame extract corner features fast represent features histogram oriented gradients hog descriptor train non linear svm descriptors test phase make used fact foreground object distinct depth ordering respect rest scene use positively classified fast features test frame initiate region growing obtain accurate segmentation foreground object rgbd data demonstrate proposed method synthetic datasets demonstrate encouraging quantitative qualitative results
background pain catastrophizing associated severe disabling migraine attacks however factors moderate relationship unknown failure inhibitory control ability suppress automatic inappropriate responses may one factor given previous research showing relationship higher lower non migraine samples research showing reduced migraine therefore examined whether lower interacts increased predict greater migraine severity measured pain intensity attack frequency duration methods women aged years old overweight obesity migraine seeking behavioral treatment weight loss migraine reduction completed day smartphone based headache diary assessing migraine headache severity participants completed modified computerized stroop task measure self report measures pain catastrophizing scale pcs anxiety depression linear regression used examine independent joint associations indices migraine severity controlling age body mass index bmi depression anxiety results participants average bmi mand reported migraine attacks migraine days days produced moderate pain intensity duration adjusting covariates higher pcs total magnification subscale beta scores significant independent correlates longer attack duration interacted total pcs beta rumination beta helplessness beta subscale scores predict headache pain intensity association pain intensity became positive lower levels conclusions results showed lower interacted higher overall specific subcomponents predict higher pain intensity migraine attacks future studies needed determine whether interventions improve could lead less painful migraine attacks via improvements
iter pulsed power electrical network ppen supplies superconducting magnets heating current drive systems experimental pulses several hundreds seconds long active power consumption reactive one mvar foreseen iter power supply system large complex careful design required assure safe operation stability iter ppen already investigated recent studies numerical simulation analytical methods new dynamic analytical model iter power supply system developed based state space theoretical approach allows application linear control theory study stability whole system subsystem iter power supply state space model developed paper converter model presented validated
plant extract mixture used present experiment containing carvacrol cinnamaldehyde capsicum oleoresin previously shown decrease diarrhea mortality modify intestinal environment pigs weaning however results obtained among experiments consistent hypothesized dietary protein could main factor determining effect plant extracts intestinal environment thus present study assessed effects piglet diets different protein sources amounts pigs weaned age allocated treatments followed factorial arrangement amounts fed basis diets various amounts protein sources diet contained low temperature fish meal level diet sbm contained plus full fat extruded soy level sbm diet contained plus full fat extruded soy level growth performance animals recorded differences detected among treatments eight pigs per treatment killed examine variables describing aspects gastrointestinal ecology diets containing sbm tended decrease ileal digestibility respectively decreased starch digestibility respectively also reduced villi length respectively tended decrease intraepithelial lymphocyte number respectively proximal jejunum inclusion also increased ileal lactobacilli enterobacteria ratio decreased vfa production cecum diets decreased level appeared favor effects studied plant extracts positive negative way depending variable measured microbial differences produced could reason improved digestive health observed authors stronger challenging conditions dirtier environments long fasting periods weaning
purpose study conducted construct test structural equation model health related quality life hrqol among hospitalized patients pulmonary tuberculosis ptb methods participants patients ptb years older admitted two national tuberculosis hospitals patients participated pulmonary function testing responded structured questionaries results goodness fit statistics final hypothetical model follows chi rmsea srmr gfi nfi cfi tli pcfi symptoms general health perception significant direct effects subjective economic status social support stigma significant indirect effect hrqol hospitalized patients ptb variables explained variance prediction model conclusion findings suggest strategies intervention physical symptoms depressive symptoms crucial improve quality life hospitalized patients ptb development various social support programs also recommended
putamen volume seen alter neurological psychiatric disorders like parkinson disease depression schizophrenia alzheimer disease individuals treated antipsychotics establish trend volume changes pathologic states studies factors influencing normal variation given population become essential study aimed evaluate normal variations putamen volume indian population correlate effects age sex bilateral symmetry also evaluated study included images individuals aged years axial sections weighted spin echo sequences used estimate putamen volume putamen delineated manually volume estimated using cavalieri principle linear regression paired test used analyze data bilateral putamen volume reduced age sexes statistically significant age sex interaction found statistically significant hemispherical asymmetry established difference right left putamen volume reach statistical significance males females conclusion study demonstrated age related decline volumes putamen males females rate volume reduction affected sex study failed establish significant sex difference hemispherical asymmetry putamen volume clin anat wiley periodicals inc
new experimental image based methodology suitable track changes orientation non spherical particles influence drag coefficient settle fluids presented given fact non spherical solids naturally develop variations angular orientation fall none intrusiveness technique analysis paramount importance order preserve particle fluid interaction undisturbed three dimensional quantitative data motion parameters obtained single camera stereo vision whilst qualitative visualizations adjacent fluid patterns achieved schlieren photography methodology validated comparing magnitudes drag coefficient set spherical particles terminal velocity conditions estimated drag correlations published literature noteworthy similarity attained fall non spherical solids particle reynolds number approximated disks cylinders exceeded values secondary motions composed regular oscillations tumbling present altered angular orientation particles respect main motion direction caused complete turbulent patterns surrounding flow therefore affecting instantaneous projected area drag force coefficient resistance impact changes angular orientation onto drag coefficient shown graphically means reinforcing existing numerical approaches however explicit relation variables could observed elsevier rights reserved
investigate full scale wind induced vibrations long span suspension bridge central span long term wind wind effect monitoring system created basic wind field characteristics along span wise direction investigated bridge analyzed found wind field along span wise direction inhomogeneous full scale wind pressure distribution around lower surface twin box girder also obtained power density functions psds fluctuating pressures vortex shedding frequency full scale twin box girder determined field visualization test performed flow pattern around lower surface obtained thirty seven vortex induced vibration viv events observed monitoring period corresponding wind conditions vibrations analyzed detail addition wind direction inflow turbulence found inhomogeneity wind field along span wise direction bridge also critical factor affects vivs full scale bridge vivs section model test full scale bridge compared found vertical viv amplitude section model much smaller field monitoring results moreover torsional vivs appeared section model test whereas observed full scale bridge elsevier ltd rights reserved
computation classically studied terms automata formal languages algorithms yet relation neural dynamics symbolic representations operations still unclear traditional eliminative connectionism therefore suggest unique perspective central issue would like refer transparent connectionism proposing accounts symbolic computation implemented neural substrates study first introduce new model dynamics symbolic space versatile shift showing supports real time simulation range automata show godelization versatile shifts defines nonlinear dynamical automata dynamical systems evolving vectorial space finally present mapping nonlinear dynamical automata recurrent artificial neural networks mapping defines architecture characterized granular modularity data symbolic operations control distinguishable activation space also spatially localizable network maintaining distributed encoding symbolic representations resulting networks simulate automata real time programmed directly absence network training discuss unique characteristics architecture consequences present two examples design central pattern generator finite state locomotive controller creation network simulating system interactive automata supports parsing garden path sentences investigated psycholinguistics experiments elsevier ltd rights reserved
paper novel digital predistortion assisted supply modulator presented proposed modulator suitable envelope tracking power amplifiers topology digitally controlled linear power amplifier used compensate switching noise ripples switching modulator proposed structure evaluated cmos process technology results show static efficiency improvement comparison previous one phase two phase architectures shown mhz wimax signal papr dbm output power maximum average efficiency achieved proposed design elsevier rights reserved
reinforcement learning theory powerfully characterizes learn benefit theory prediction errors difference predicted actual outcome choice drive learning however operate social vacuum behave prosocially must learn consequences actions people empathy ability vicariously experience understand affect others hypothesized critical facilitator prosocial behaviors link empathy prosocial behavior still unclear functional magnetic resonance imaging fmri participants chose different stimuli probabilistically associated rewards self another person prosocial one control using computational modeling show people learn obtain rewards others slowly learning obtain rewards fmri revealed activity posterior portion subgenual anterior cingulate cortex basal forebrain sgacc drives learning acting prosocial context signals prosocial prediction error conforming classical principles reinforcement learning theory however also substantial variability neural behavioral efficiency prosocial learning predicted trait empathy empathic people learn quickly benefitting others sgacc response selective prosocial learning thus reveal computational mechanism driving prosocial learning humans framework could provide insights atypical prosocial behavior disorders social cognition
organizational theory long emphasized importance contingent environmental influences organizational performance similarly research demonstrated importance local political culture informal management performance local health system establishing vicious virtuous circles influence contribute increasing inequalities performance among decentralized local health systems longitudinal ethnography studied relationship elements rural municipality northeast brazil four year interval second study found local health system performance much improved two main factors appear interacted bring leadership vision power implement one individual professionalization local health system hiring significant number senior health staff origins influences combine initiatives local state federal levels
dealing work related stress highly prevalent employees gynecology medicine junior physicians particular face high working demands challenges starting medical career graduation job resources social support personal resources coping skills might reduce job strain evidence supportive effective mental health interventions clinicians limited offering psychosocial skill training entrants gynecology medicine expected highly beneficial following present pilot study focused strengthening physicians psychosocial skills analyzed effects innovative training junior gynecologists working german hospitals coping skills training junior gynecologists offered group training weekly sessions time period months physicians randomized either intervention group receiving training control group training content involved developing learning coping skills well solution focused cognitive behavioral counselling junior gynecologists study outcomes perceived occupational stress emotional exhaustion resilience coping behavior emotion regulation skills job satisfaction surveys distributed baseline training months junior gynecologists reported significant decrease perceived job stress emotional exhaustion baseline follow ups whereas control group show comparable results clear positive value mental health promotion program also noticeable regard job satisfaction increased coping skills emotion regulation overall satisfaction skill training high gynecologists reported high scores training design content received outcome overall satisfaction training pilot study participating psychosocial skills training course adapted gynecology clinicians associated reductions perceived job stress exhaustion improvements coping skills satisfaction modified psychosocial skills training may time efficient tool support gynecologists performance well may positive implications patient care
subtropical watershed wetland covering nearly southeastern united states florida everglades degraded human dominated environment unique important ecosystem everglades provide variety important environmental services society nature past century half anthropogenic actions severely impacted everglades disrupting natural water flow causing water pollution result native flora fauna displaced important habitats lost invasive species become prevalent water contaminant concentrations increased accelerating efforts made towards preserving everglades ecosystem restoring water flow improving water quality explore complex important aquatic ecosystem critically review relevant environmental history major terrestrial aquatic characteristics dynamics engineered changes water flow major sources impacts nutrient pollution trends system response pollution mitigation actions recent regulatory efforts driving restoration
order tackle ambiguities geometrical product specification gps geospelling language developed express semantics specifications detailed syntax geospelling proposed paper specification defined sequence operations skin model syntax based instructions used computer programming language call functions flow control condition loop geospelling call functions corresponds declaration operations loops make possible manage set features rigor conditions select features set
intracardiac leiomyomatosis rare complication occurs uterine leiomyoma fibroid undergoes vascular invasion propagates within inferior vena cava reach right atrium article describes case intracardiac leiomyomatosis middle aged woman exploring presentation diagnosis surgical management condition case presenting complaints syncope atrial fibrillation illustrating importance performing transthoracic echocardiogram patients presenting first episode atrial fibrillation clinicians consider intracardiac leiomyomatosis evaluating women right heart masses especially history uterine leiomyomas
cugas thin film fabricated electrochemical deposition alloys alcohol solution eliminate interference hydrogen evolution reaction process involves electrodeposition precursor molybdenum substrate subsequential annealing sulfur vapor formation cuga alloy precursor observed pure ternary chalcopyrite cugas phase good polycrystalline structure without secondary phase obtained thermal treatment influence applied deposition potential crystalline phase morphology compositions carrier concentration films investigated results show optimum choice electrodeposition potential necessary obtain pure crystallized cugas thin film lower absolute deposition potential results higher ratio emergence cus secondary phase annealing sulfur atmosphere crystal size formed cugas phase thermal annealing process increases positive shift deposition potential impedance spectroscopy test demonstrates semiconductor property synthesized cugas polycrystalline thin films type carrier density obtained cugas thin films increases negative shift deposited potential
background monoclonal antibodies drugs directed tnf alpha tnf alpha inhibitors immunogenic consequent anti drug antibodies ada formation may decrease functional drug concentration resulting loss response evaluated impact ada tnf alpha therapeutic response methods considered studies enrolling adult patients affected autoimmune inflammatory disease therapy tnf alpha inhibitors collected data study population characteristics treatment dosage determination ada adverse events combined data meta analysis calculating risk ratios study values considered statistically significant methodological quality evaluated analyses performed stata revman softwares results included studies enrolling patients developed ada analysis showed significant reduction response patients ada respect patients without especially patients treated infliximab adalimumab furthermore administration tnf alpha inhibitors produced reaction infusion site infection serious patients conclusion detectable ada significantly reduced tnf alpha inhibitors response drug administration also cause injection site reaction infections early detection serum ada levels may improve patients management currently many indications use immunogenicity tests guide therapy information regarding implement clinical practice needed elsevier rights reserved
nowadays increasingly stringent directives transport sector open interesting possibilities development new traction technologies based electrochemical storage fuel cells characterized limitations electrochemical storage systems limited range fuel cells proper response capability variable load demands aim realize hybrid electric vehicle hev able increase range autonomy cnr itae designed minibus class category electric motor powered polymeric fuel cell system lithium battery system kwh study focused evaluation hybrid propulsion system performance different operating conditions particular powertrain configuration energy management strategies studied optimize efficiency hev overcoming limitations technologies reducing energy losses increasing range vehicle tests road conducted energy production consumption vehicle logged hydrogen energy publications llc published elsevier ltd rights reserved
chapter describes involvement lung systemic inflammatory joint disease particular focus rheumatoid arthritis although topics pulmonary involvement ankylosing spondylitis psoriatic arthritis also addressed interstitial lung disease lethal pulmonary complication chapter describes recent advances understanding complication therapeutic options offer real hope improved outcomes although less well recognised airways disease common association described detail section devoted recent surge interest bronchiectasis acute pulmonary infection common management reviewed detail although pleural disease less common treatment explored conclude reviewing relationship drug therapies employed effects lung crown copyright published elsevier ltd rights reserved
examined proportions multiple types breast cancers population attributable established risk factors focusing behaviors modifiable menopause estimated full partial population attributable risk percentages par combining relative risks observed prevalence rates risk factors interest total cases invasive breast cancer developed postmenopausal women nurses health study included following modifiable risk factors analyses weight change since age years alcohol consumption physical activity level breastfeeding menopausal hormone therapy use additionally following nonmodifiable factors included age age menarche height combination parity age first birth body mass index age years family history breast cancer prior benign breast disease considered risk factors controlled age par invasive breast cancers confidence interval considering modifiable factors found changing risk factor profile lowest weight gain alcohol consumption high physical activity level breastfeeding menopausal hormone therapy use associated par confidence interval par modifiable factors higher estrogen receptor positive breast cancers par estrogen receptor negative breast cancers par risk factors modifiable menopause account one third postmenopausal breast cancers therefore substantial proportion breast cancer united states preventable
binge drinking associated impaired cognitive functioning relationship cognitive impairments white matter integrity less known used diffusion tensor imaging dti investigate relationships binge drinking whole brain white matter integrity cognitive performance young adulthood years period continued brain development two sessions year apart binge drinkers non binge drinkers underwent dti completed measures spatial working memory motor impulsivity fractional anisotropy measure derived dti estimated whole brain five segments corpus callosum prefrontal premotor supplementary motor motor sma sensory parietal temporal occipital pto lower binge non binge men women session measurements except motor segment significantly increased session session lower prefrontal pto segments associated higher binge score whereas lower five segments associated greater drug use men worse spatial working memory men women findings extend literature showing early adulthood binge drinking drug use linked degradations neural white matter compromised white matter period brain development linked impaired cognitive functioning
background pathophysiologic mechanisms underlying acute exacerbation idiopathic pulmonary fibrosis ipf fully understood studies examined autopsy findings patients died acute exacerbation ipf pathologic findings systemic organs described methods retrospectively reviewed autopsy findings patients died acute exacerbation ipf two connective tissue disease associated interstitial lung disease recorded demographic clinical characteristics autopsy findings cytologic findings peripheral blood results median age autopsy years range years subjects men high dose corticosteroid cyclophosphamide oxygen therapy administered patients underlying lesions usual interstitial pneumonia pattern diffuse alveolar damage contraction band necrosis observed cases large cells expressing scavenger receptor sra observed systemic circulation cases acute exacerbation cells expressing tumor necrosis factor alpha tnf alpha detected diagnosis nine detected cases autopsy neutrophil platelet accumulation predominantly capillaries extensive capillary endothelial cells injury conclusions findings suggest acute exacerbation ipf systemic consequences multiple organ injury sra tnf alpha cells systemic circulation playing central roles multiple organ injury
problem focused interviews three german surgical clinics anxieties affect adoption ambient intelligence healthcare investigated research reveals anxieties grouped categories containing implementation anxieties ambient intelligence hospitals results expand basis theory underlying technology related anxieties medical professionals offer theoretical practical implications leading initial basis decisions regarding implementation ambient systems
objective overactive bladder syndrome chronic disease high prevalence rate syndrome requires long term therapy treatment persistence months decline one year period low main reasons stopping treatment low efficacy medication work expected side effects much satisfied patients mirabegron persisting treatment answer question provided secondary analysis multicentre follow study patients mirabegron compared subjective objective parameters patients continuing mirabegron treatment discontinued medication design secondary analysis multicentre prospective follow settings gyn department first faculty medicine charles university general university hospital prague methods secondary analysis multicentre prospective study following patients mirabegron treatment analysed objective data micturition diary subjective data using visual analogue scales vas urgency bother visual analogue scale vas treatment satisfaction visual analogue scale compared data group patients continuing mirabegron treatment patients stopped medication study results included patients women men diagnosis overactive bladder patients continuing treatment group baseline ubvas patients stopped medication follow period group baseline episodes severe urgency urge incontinence six months urgency bother score vas treatment satisfaction tsvas number severe urgencies without urge incontinence months lower group continuing treatment comparing data patients stopping medication reason low efficacy group patients stopping reasons group vas bas vas number severe urgency without incontinence conclusion data shows patients expectation treatment mirabegron low patients accept treatment either without side effects decrease severe urgency without urge incontinence around regardless reason patients continuing treatment scale treatment satisfaction tsvas points
soft drink industries suffer inadequate handling product losses generally considered wastes products contribute wastewater organic load augmentation cause fastidious environmental impact study industrial scale bioconversion process based multistage fermentation proposed treat reuse soft drink factories high loaded effluents valuable components production upstream segregation non consumed beverage performed reduce organic load soft drink wastewater beverage characterization revealed important sugar content organic compound undoubtedly responsible high organic load soft drink wastewater thus bioconversion sugar content soft drink waste single cell proteins proposed solution reduce wastewater polluting load soft drink wastewater including rejected returned products tested used substrate yeast biomass production using commercial yeast strain saccharomyces cerevisiae effect nutrient supplementation initial sugar concentration effect culture media biomass production investigated using batch fed batch process results indicated supplementation necessary successful fermentation juices nectars gave better sugar biomass conversion yields depletion sugar contained soft drinks exceeded fermented media fed batch culture revealed biomass concentration improvement reaching compared batch biomass concentration resulting batch cultures proposed process shown enable beverage industries reduce water pollution generation site segregation procedure storage system valorize product losses source medium single cell protein production
anti tnf alpha agents emerged inflammatory bowel disease ibd effective option situations otherwise would refractory medical therapy cytomegalovirus infection may present high spectrum manifestations lead high morbidity mortality however clinical significance ibd course remains unknown data association anti tnf alpha limited study aims evaluate cytomegalovirus cmv infection disease patients ibd treated anti tnf alpha possible possible risk factors associated cmv infection disease ibd patients anti tnf alpha well influence cmv infection disease ibd course would determined three consecutive years ibd patients starting infliximab department included cytomegalovirus status anti tnf alpha evaluated data regarding ibd therapeutic ibd course infliximab recorded cmv analysis performed polymerase chain reaction pcr cytomegalovirus peripheral blood colonoscopy biopsies histopathology immunohistochemistry included patients female crohn disease ulcerative colitis non classified colitis cytomegalovirus seropositive median follow months follow patients combination therapy azathioprine least cycle corticosteroids twenty one patients responded infliximab registered exacerbations ibd four patients discontinued infliximab none cmv infection documented case intestinal cytomegalovirus infection detected biopsies performed per protocol asymptomatic patient responded valganciclovir without infliximab discontinuation infliximab without immunosuppression confer increased risk activation cytomegalovirus cytomegalovirus responsible neither significant morbidity mortality ibd
estimation marginal partial effects covariates various conditional parameters functionals often main target applied microeconometric analysis specific context probit models estimation partial effects involving outcome probabilities often interest estimation straightforward univariate models results covering case quadrant probability marginal effects bivariate probit models jointly distributed outcomes previously described literature paper goals extend greene results encompass general multivariate probit context arbitrary orthant probabilities extended results models condition subvectors multivariate ordered probit data structures suggested partial effects broadly useful situations wherein multivariate outcomes concern
recent years smart mobile devices bolstered new interaction scenarios require sophisticated human machine interfaces leading developers operating systems devices provide apis application programming interface developers implement applications including different solutions developing graphical interfaces control sensors providing oral interaction despite usefulness resources defined strategies still needed developing multimodal interfaces take greater advantage devices identifying meeting needs users currently applications typically hoc facilitate oral communication simple commands paper propose practical application context sensitive multimodal conversational agents provide advanced library services dynamically consider specific user needs preferences well specific characteristics environment interaction occurs agents would improve customize service provided mobile device internet access proposal integrates features android apis modular architecture emphasizing management interactions context awareness order create robust applications easily updated adapted user
chlorpromazine phenothiazine derivative primarily used schizophrenia occasionally migraine plays important role pain sensation investigated whether chlorpromazine blocks human hna sodium current hek cells stably expressing hna using whole cell patch clamp technique peak current hna reduced chlorpromazine concentration dependent manner half maximal inhibitory concentration hill coefficient calmodulin inhibitory peptide abolish blockade hna currents chlorpromazine blockade hna currents chlorpromazine completely repeatedly reversible washout half maximal voltage activation hna changed chlorpromazine however chlorpromazine caused hyperpolarized steady state inactivation hna recovery inactivation presence chlorpromazine slower absence chlorpromazine chlorpromazine also showed strong use dependent inhibition hna current results demonstrate chlorpromazine blocks hna current concentration state use dependent manners suggest merits study potential use pain management elsevier ireland ltd rights reserved
growing recognition parental socialization influences interact young children emerging capacity physiological regulation shape children developmental trajectories nevertheless transactional processes linking parental socialization physiological regulatory processes remain well understood particularly fear prone toddlers address gap literature present study investigated biopsychosocial processes underlie toddlers fear regulation examining relations among toddler parasympathetic regulation maternal appraisal parenting behaviors participants included mothers toddlers age months participated longitudinal study temperament socio emotional development toddlers parasympathetic reactivity found moderate links maternal anticipatory appraisal child fearfulness maternal provision physical comfort preschool age child inhibition additionally maternal comforting behaviors low threat task predicted preschool age separation distress specifically toddlers demonstrating low baseline rsa
alterations luteinizing hormones testosterone levels following short acting opioid ingestion unknown may assist diagnosis hypogonadism opioid consumers serial luteinizing hormones testosterone values measured every hours hours following ingestion either hydrocodone multiple isolated occasions demonstrated testosterone levels hours ingestion lower difference resolving within post ingestion hours indicating knowledge recent hydrocodone ingestion may valuable interpreting significance low morning testosterone levels patients
purpose application zero valent iron nanoparticles innovative technology ground water treatment soil remediation several methods synthesise nano scale zero valent iron nzvi namely bottom methods consists chemical reactions using strong reducing agents work environmental impacts costs determined two methods namely traditional one uses sodium borohydride green method uses extracts obtained natural products methods consideration environment economic aspects earlier stages synthesis processes development new materials great importance since help decide alternative methods promising developed aiming sustainable processes work life cycle assessment lca used ecodesign strategy evaluating environmental performance two synthesis methods identifying critical stages synthesis processes nzvi economic evaluation sensitivity analysis considering different scenario electricity production also performed results discussion results obtained study showed green synthesis method presents lower environmental impacts traditional one roughly lower first scenario second scenario environmental impact green synthesis corresponds environmental impact traditional synthesis green method critical stage extraction process closely related electricity production traditional method reactant use critical stage related production sodium borohydride economic evaluation indicated traditional synthesis method much expensive green synthesis roughly eight times higher conclusions results obtained possible conclude green synthesis method presents lower environmental impacts scenarios lower costs traditional synthesis
long term ketamine abuse affect urinary system resulting lower urinary tract symptoms luts pathogenesis still unknown previous studies demonstrated ketamine change expression brain derived neurotrophic factor bdnf serum ketamine abuse patients aim present study explore mechanism ketamine mediated bdnf signaling pathway bladder rats chronic ketamine treatment rats randomly assigned control normal saline ketamine group five rats group experimental group given ketamine via intraperitoneal injection daily control group treated saline weeks treatment bladders excised samples control ketamine group examined transmission electron microscopy tem phosphoprotein non phosphoprotein purification histopathology immunohistochemistry western blot carried groups histological study showed hyperplastic epithelium inflammatory cell infiltration ketamine treated rat bladders tem showed chronic ketamine treatment results structural damage organelles immunohistochemical staining western blot showed expression bdnf significantly lower ketamine group however expression phosphorylated extracellular signal regulated kinases erk ketamine group higher whereas total erk similar control group long term ketamine abuse reduces expression bdnf inducing phosphorylation erk bladder wall may play important role pathogenesis ketamine associated luts
objective describe effect antiretroviral therapy art hiv related factors high risk human papillomavirus hpv high grade cervical intraepithelial neoplasia lesions cin among women living hiv aids wlha sub saharan africa design prospective cohort wlha ouagadougou burkina faso johannesburg south africa recruitment stratified art status methods baseline endline median months cervical samples biopsies analyzed hpv genotyping innolipa histology logistic regression used estimate associations art hiv related factors hpv cin outcomes results presented adjusted baseline cell count results among enrolled wlha hpv prevalence cin prevalence compared long duration art users years hpv prevalence higher among short duration art users years adjusted prevalence ratio apr confidence interval cin prevalence higher among short duration art users adjusted odds ratio aor art naive participants aor among women seen endline hpv persistence cin incidence months hpv persistence associated art naive apr short duration art use apr hiv plasma viral load least copies apr cin incidence reduced among women art aor conclusion prolonged effective art important controlling hpv development cin copyright wolters kluwer health inc rights reserved
background objective assess prevalence hypertension diabetes dyslipidaemia subjects subclinical hypothyroidism comparison age sex matched control group patients methods case control study subjects controls carried patients aged years admitted primary care centre prevalence hypertension diabetes dyslipidaemia well blood pressure plasma glucose lipid profilses evaluated groups results differences observed neither prevalence hypertension diabetes mean values blood pressure plasma fasting glucose subjects increased prevalence lipid abnormalities increased mean values total cholesterol compared control group conclusion patients increased prevalence lipid abnormalities responsible increased cardiovascular risk patients elsevier espana rights reserved
consistent depth positioning seeds vital achieving optimum yield agricultural crops state art seeding machines depth drill coulters vary changes soil resistance paper presents retrofitting angle sensor pivoting point drill coulter providing sensor feedback control system via electro hydraulic actuator delivers constant coulter depth results showed strong correlation angle coulter coulter depth static dynamic operations verified sub millimetre accurate positioning system igps nikon metrology belgium mounted drill coulter drill coulter depth controlled ordinary fixed spring loaded force change soil resistance reduced mean depth dynamically controlling spring loaded force based angle sensor mean depth independent seedbed resistance change shown tests soils ranging sand gravel pid controller effective providing mean depth deviation target depth sand gravel respectively cost efficient control function found three position control system resulting mean depth deviation target depth sand gravel respectively fast fourier transform fft analysis coulter depth measurements showed control system also provided damping effect coulter depth variations research showed possible minimise low frequency drill coulter depth variations provide consistent coulter depth independent soil conditions using developed sensor system control system elsevier rights reserved
paper present design fabrication thermal simulation smart element pixels monolithic pyroelectric functional electro ceramic material based infrared image sensors sol gel deposited pbzr pzt thin film used pyroelectric material detector tailored geometries dimensions devices designing image sensors smart material influence thermal isolator shown significantly reduce heat loss device structure environment introducing circular pixels instead square ones confirmed ability obtain optimal design functional material use smart image sensor resulting maximal temperature change response frequency
loss surface expression circulating malignant cell widely accepted diagnostic marker patients leukemic cutaneous cell lymphoma ctcl ctcl cases reemergence surface expression unusual uncertain prognosis report case erythrodermic leukemic mycosis fungoides patient achieved temporary remission several months multimodality immunotherapy extracorporeal photopheresis relapsed aggressive disease phenotypically characterized cells high expression polymerase chain reaction studies high throughput sequencing analyses peripheral blood mononuclear cells presentation relapse consistently showed identical clonal cell receptor suggesting evolution original malignant clone lacked expression interestingly quantitative expression sialomucin mirrored clinical picture thus favoring reliability novel biomarker ctcl
systematic data based design method tuning proportional integral derivative pid controllers disturbance attenuation proposed method set closed loop plant data directly exploited without using process model pid controller parameters control system behaves closely possible reference model disturbance rejection derived two algorithms developed calculate pid parameters one algorithm determines optimal time delay reference model solving optimization problem whereas algorithm avoids nonlinear optimization using simple approximation time delay term enabling derivation analytical pid tuning formulas plant data integrals used regression equations calculating pid parameters two proposed algorithms robust measurement noises moreover controller tuning involves adjustable design parameter enables user achieve trade performance robustness closed loop tuning capability proposed method applied online improve retune existing underperforming controllers stable integrating unstable plants simulation examples covering wide variety process dynamics including two examples related reactor systems presented demonstrate effectiveness proposed tuning method isa published elsevier ltd rights reserved
flash flood forecasting catchment systems one challenges especially arid ungauged basins study attempted estimate relationship rainfall runoff also provide flash flood hazard warnings ungauged basins based hydrological characteristics using geographic information system gis morphometric characteristics drainage basins provide means describing hydrological behavior basin study examined morphometric parameters wadi rabigh emphasis implication hydrologic processes integration analysis morphometric parameters gis techniques data study obtained aster data digital elevation model dem resolution topographic map geological maps subject field confirmation morphometric parameters measured calculated interlinked produce nine effective parameters evaluation flash flood hazard degree study area based nine effective morphometric parameters directly influence hydrologic behavior wadi time concentration flash flood hazard rabigh basin subbasins identified classified three groups high medium low hazard degree present work proved physiographic features drainage basin contribute possibility flash flood hazard evaluation particular drainage area study provides details flash flood prone subbasins mitigation measures study also helps plan rainwater harvesting watershed management flash flood alert zones based two historical data events rainfall corresponding maximum flow rate morphometric parameters stormwater management design aid software smada could generate hydrograph wadi rabigh basin result model applied wadi rabigh basin rainfall event total duration station nearby study area exceedance probability return period around years produces discharge volume delta outlet basin rainfall infiltrates recharge
embedded systems routinely deployed critical infrastructures nowadays therefore security increasingly important combined pressing requirement deploying massive numbers low cost low energy embedded devices stimulates evolution lightweight cryptography green computing security mechanisms new crypto primitives proposed offer moderate security produce compact implementations article present lightweight authenticated encryption scheme based integrated hardware implementation lightweight block cipher present lightweight hash function spongent presented combination cipher hash function appropriate implementing authenticated encryption schemes commonly utilized one way mutual authentication protocols exploit inner structure discover hardware elements usable primitives thus reducing circuit size integrated versions demonstrate reduction hardware area compared simple combination two primitives resulting solution ported field programmable gate array fpga complete security application input output universal asynchronous receiver transmitter uart gate created comparison similar implementations hardware software proposed scheme represents better overall status
main contribution paper modeling approach used describe pure three phase shunt active filter application infinity control design tool order improve quality electrical energy advanced power electronics devices widely contributed degradation power quality due injection non sinusoidal currents utility system therefore essential use active compensator attenuate current harmonics acceptable level line side power source work three phase active filter connected parallel supply system feeding non linear load described complex framework linear multivariable state space representation order guarantee system mathematically decoupled therefore simplify controller design representation includes sensor measure perturbations allows one calculate linear robust control law originality paper linear matrix inequality based infinity synthesis performed design static state feedback controller complex valued parameters robustness controller respect network impedance uncertainties investigated moreover simulation experimental results given reveal effectiveness synthesized control law
essential thrombocythemia rare clonal myeloproliferative disorder prevalence rate approximately cases per individuals per year characterized persistent increase platelet count hyperplasia bone marrow megakaryocytes difficult make diagnosis thrombocythemia reactive certain disease conditions including iron deficiency anemia infection collagen diseases malignant tumors mutation janus kinase jak gene present approximately patients somatic mutations calreticulin calr gene recently discovered approximately sporadic patients primary myelofibrosis various cutaneous manifestations often occur microvascular thrombosis precede severe arterial venous thromboembolic events organs therefore order prevent severe events important make early diagnosis based number cutaneous manifestations report two cases diagnosed based livedo racemosa feet gene mutations jak calr respectively show pathological immunohistological findings livedo resulting platelet thrombosis rather vasculitis also review cutaneous manifestations current published reports japanese patients patients successfully treated low dose aspirin vasodepressor hydroxyurea following regressed livedo reduced platelet counts
paper studies gathering problem grid tree networks team robots placed different nodes input graph meet node remain robots operate look compute move cycles one cycle robot perceives current configuration terms occupied nodes look decides whether move toward one neighbors compute positive case makes computed move instantaneously move cycles performed asynchronously robot problem deeply studied case ring networks however known techniques used rings directly extended grids trees moreover rings another assumption concerning called multiplicity detection capability required order accomplish gathering task robot able detect look operation whether node empty occupied one robot occupied undefined number robots greater one paper provide full characterization gatherable configurations grids trees particular show topologies multiplicity detection required interestingly sometimes problem appears trivial case grids odd sides sometimes involved techniques require new insights respect well studied ring case moreover results reveal importance structures like grids trees allow overcome multiplicity detection respect ring case elsevier rights reserved
paper presents intelligent technique condition based self maintenance aluminum electrolytic capacitors circuit condition capacitors monitored calculating remaining useful life real time basis capacitor condition self maintained operation performed controlling case temperature using thermo electric cooling tec module temperature difference two plates tec module obtained varying duty ratio input voltage waveform capacitor case temperature dependent temperature capacitor controlled maintaining cold side temperature tec function change case ambient temperature proposed scheme implemented national instruments labview software low cost microcontroller board used data acquisition control make developed system flexible use two different modes operation monitoring mode self maintenance mode provisions auto shut test circuit critical condition capacitor also manual shut maintenance purposes scheme equipped web based remote monitoring maintenance feature proposed technique customized condition monitoring maintenance critical components power electronic system
objective long interest nutritional contribution onset treatment mood disorders increasing scientific evaluation several candidate nutritional dietary factors recent years paper overview research vitamin insufficiency deficiency contribution depression method relevant literature reviewed results cross sectional studies identified associations depression low vitamin levels studies failed clarify whether vitamin deficiency antecedent cause correlate consequence depression vitamin deficiency insufficiency linked seasonal affective disorder suggested associations rigorously tested insufficient research establish whether vitamin supplementation considered augmentation strategy antidepressant drugs conclusion currently insufficient evidence argue strongly vitamin supplementation patients depression strategy worthy consideration depressed patients whose lifestyle geographical residence may indicate risk vitamin insufficiency low vitamin levels quantified
increasingly health care delivered large complex organizations physicians must learn function effectively result several medical business schools developed joint programs train physician leaders receive medical degree master business administration mba degrees examined several themes relation programs revolving around concerns attracted whether exposure differing cultures medicine business impact professional identities graduates manifested motivations aspirations careers addressed issues studying students joint mba program harvard medical school hms harvard business school hbs data came several internal sources survey students enrolled joint program spring found relatively differences joint program students equivalent cohorts hms students terms personal characteristics preadmission performance performance hms hbs contrary concerns programs may draw students away medicine vast majority embraced careers involving extensive postgraduate medical training long term plans leveraged new perspectives skills improve health care delivery
motivated recent london penetration depth measurement kim phys rev lett novel composite pairing scenario erten flint coleman phys rev lett doped heavy fermion superconductor cecoin revisit issue superfluid response microscopic heavy fermion lattice model however literature explicit expression superfluid response function heavy fermion superconductors rare paper investigate superfluid density response function celebrated kondoheisenberg model specific derive corresponding formalism effective fermionic large mean field pairing hamiltonian whose pairing interaction assumed originate effective local antiferromagnetic exchange interaction interestingly find physically correct temperature dependent superfluid density formula obtained external electromagnetic field directly coupled heavy fermion quasi particle rather bare conduction electron local moment unique feature emphasizes key role kondo screening renormalized heavy quasi particle low temperature energy thermodynamics transport behaviors important application theoretical result compared experimental measurement heavy fermion superconductors cecoin doped xybx coin fairly good agreement transition pairing symmetry latter material explained simple doping effect addition requisite formalism commonly encountered nonmagnetic impurity non local electrodynamic effect developed inspired success explaining classic series heavy fermion superconductors expect present theory applied understand heavy fermion superconductors cecusi generic multi band superconductors
acute kidney injury aki leads chronic kidney disease mechanisms involved recovery aki poorly understood molecular mediators responsible healing restoration kidney function understudied previously discovered differential expression matrix metalloproteinase mmp mrna protein patients severe sepsis associated aki versus sepsis without aki demonstrate involvement mmp purely ischemic aki mice subjected min bilateral renal ischemia developed increased plasma creatinine mmp expression within versus sham controls initial surge subsequent return toward baseline kidney mmp expression activity exhibited late increase days post ischemia reperfusion mice subjected aki neutrophil infiltration kidney significantly higher aki wild type mice mmp null mice starting days additionally mmp null mice subjected aki demonstrated persistent histopathologic functional injury worsened health greater overall weight loss versus wild type cohorts seven days taken together findings suggest mmp involved restoration baseline kidney health ischemic kidney injury potential mechanism involves interaction mmp neutrophil recruitment site injury
lung cancer screening low dose computed tomography ldct scan covered centers medicare medicaid services following evidence based recommendation shared decision making process inform patients risks limitations awareness campaign promoting ldct screenings opportunity elicit patient engagement health providers risks benefits focus groups representing three regions appalachian kentucky known high lung cancer rates discussed development lung cancer screening campaign recommendations included messaging content appeals design campaign implementation trusted information communication sources community health workers chws three eastern kentucky regions recruited individuals local communities using established client files chws hosted six total focus groups participants using questions guided communication persuasion matrix framework sessions recorded transcribed independent content analysis total individuals female pack year history participated prior discussion participants heard lung cancer screening cited needs content campaign included benefits early detection payment information messages considered persuasive include personal testimony messages hope prolonged life emphasis family ambition survive information come one family doctor specialty provider considered important message communication messages survivorship family prolonged life considered lung cancer screening awareness campaigns results provide community input messages regarding screening options
style dynamics volcanic eruptions control level type hazards posed local populations temporary long range impact climate eruptions extremely energetic purpose study provide statistical approach ash morphometrics order provide means evaluate diverse eruption styles mechanisms fragmentation methodology presented applied tephra deposits worldwide may aid volcanic hazard mitigation better defining volcano history explosive behavior ash sized grains collected tephra deposits mount erebus antarctica total data variance interpreted represent continuum fragmentations involving water magma interaction wet grains formed predominately magmatic dry fragmentation mechanisms taupo hatepe ash deposited phreatoplinian eruption column highest factor values array signifies part rectangular blocky morphologies smooth grain edges factor values redoubt eruption events nearly high hatepe ash based suggest produced part phreatomagmatic fragmentation supported field observations document melting eruption glacial ice early phases activity redoubt ash grains later stages eruption events show significant shift lower values factor space irregular vesiculated grains interpreted consequence dryer conditions coarse ash data mount erebus completely separated taupo redoubt grains factor space due primarily difference mean gray value proxy vesicle density size vesicle characteristics larger deeper consistent documented strombolian style activity scatter grain shape data support fragmentation mixture wet dry processes previously proposed based deposit characteristics resemblance tephra produced current activity elsevier rights reserved
three month long acting paliperidone new recently marketed formulation paliperidone characterised longest available dosing interval among long acting antipsychotics clinical profile month long acting paliperidone recently summarised european medicines agency ema public assessment report released april commentary main strengths limitations ema assessment report appraised discussed order highlight possible implications clinical practice future research regulatory practices drug approval
paper consider possibility hidden data since today network services rely basic protocols use data transmission capacities taken account untestable redundant fields may become big problem modern data protocols vulnerabilities attacker use reserved fields field use undocumented way regarding mechanism transfer detection methods described gears work great practical interest implementation systems detect prevent intrusions data leaks authors use mechanisms transmission detection transfers using comparative evaluation fields packet values recommended standard protocol
overall objectives research performed icollaborate materials science engineering mse project measure improvements student learning outcomes student engagement successful course completion rates possible structure basic materials engineering course transformed primarily deductive practice information communication technology ict enabled inductive teaching learning environment two overarching components project first component required transformation course structure deductive practice inductive practice element supported research results stem education educational theory based cognitive social constructivism second component ict support additional research base supports connections ict enhanced collaborative learning distributed cognition enhanced student outcomes propose ict support combined immersion inductive teaching learning environment improve student outcomes either singular component case capabilities ipod touch allowed build applications apps utilize different multi media formats eight different mse apps built far apps facilitate support daily collaborative learning opportunities target specific student learning objectives known challenging weekly class low stakes quizzes help students evaluate well building knowledge base three kinds data sets used evaluate research data set one deductive practice data set two inductive practice third data set collecting similar data set two ict support work progress paper describe project theoretical base apps experiences deployment devices focus group findings national science foundation supporting project nsf ccli
even simple geometric shapes seen animate goal directed move certain ways previous research revealed great deal cues elicit percepts much less consequences aspects perception cognition explored whether simple shapes perceived animate goal directed prioritized memory investigated asking whether subjects better remember locations displays seen animate inanimate controlling lower level factors exploited wolfpack effect moving darts discs eyes stay oriented toward particular target seen actively pursuing target even actually move randomly contrast shapes stay oriented perpendicular target correctly perceived drifting randomly subjects played matching game clicking pairs panels reveal animations moving shapes across four experiments locations wolfpack animations compared control animations equated lower level visual factors better remembered terms efficient matching thus perceiving animacy influences subsequent visual memory perhaps due adaptive significance stimuli elsevier rights reserved
jens rasmussen multifaceted legacy includes cognitive work analysis cwa framework analysis design evaluation complex sociotechnical systems considering framework origins paper reviews progress predictably covering experimental research ecological interface design case studies application cwa human factors engineering problems industry methods modelling tools cwa emphasis placed however studying nexus recent results obtained cwa original field studies human problem solving motivated framework development particular interest case study use cwa military doctrine development problem commonly regarded lying outside fields human factors engineering concluded value cwa even diverse problems likely result conceptual grounding empirical observations patterns human reasoning complex systems crown copyright published elsevier ltd
opportunities challenges petrochemical industry emergence massive disruptive technologies triggered new revolution power fundamentally change industrial processes including manufacturing engineering materials supply chains lifecycle management recently newly arisen smart factory adopted disruptive manufacturing methodology become key part petrochemical industry smart factory different original production systems used petrochemical industry needs assess position future research agenda including definition intension framework technology systems thinking systems problem solving smart factory must prioritized based analysis driving force smart factory development paper proposes lifecycle blueprint consensus based operating technology roadmap definition features smart factory petrochemical industry presented furthermore summary technical systems future proof research field smart petrochemical factory academic industrial viewpoint presented elsevier ltd rights reserved
simple low power low area metal oxide semiconductor field effect transistor fully differential bit pipelined analog digital converter stage proposed designed taiwan semiconductor manufacturing company technology using bsimv parameters supply voltage inexpensive digital complementary metal oxide semiconductor cmos technology based charge pump technique achieve desired voltage gain independent capacitor mismatch avoiding need power hungry operational amplifier based architecture reduce power area cost various capacitances implemented metal oxide semiconductor capacitors offering compatibility cheaper digital cmos process order reduce much required manufacturing cost
series bearing capacity tests conducted eccentrically loaded model surface shallow strip footings resting close reinforced finite sand slopes investigate ultimate loads failure surfaces load displacement curves rotation footing etc experimental set used run tests consists tank model footing sand loading mechanism single woven geotextile strip sheet placed horizontally footing base depth half footing width ultimate loads decreased increasing eccentricity decrease due combination eccentricity slope use geotextile reinforcement increased ultimate loads comparison unreinforced cases failure surfaces symmetrical primary failure surfaces developed eccentricity slope side secondary failure surfaces developed side lengths failure surfaces decreased increasing eccentricity prior failure footings always rotated towards eccentricity slope side degrees
freezing gait fog parkinson disease likely results dysfunction within complex neural gait circuitry involving multiple brain regions herein cerebellar activity increased patients compared healthy subjects cerebellar involvement proposed compensatory hypothesized patients fog would reduced ability recruit cerebellum compensate dysfunction brain areas study cerebellar activity modified unilaterally either excitatory inhibitory theta burst stimulation tbs applied two separate sessions ipsilateral cerebellar hemisphere corresponding body side affected stimulated seventeen patients showing state fog participated presence fog verified objectively upon inclusion monitored gait bimanual rhythmic upper limb movements directly tbs gait evaluated fog provoking protocol including rapid degrees turns walking test small fast steps upper limb movement performance evaluated repetitive finger flexion extension task tbs affect amount freezing walking finger tapping however tbs increase gait speed walking small steps decreased gait speed walking fast possible normal step size changes gait speed accompanied changes corticospinal excitability unilateral cerebellar tbs improve fog however changes gait speed found suggests role cerebellum
background study aimed investigate effects polymorphisms genes encoding carbon metabolism enzymes differential development metabolic parameters weeks treatment second generation antipsychotics first episode schizophrenia patients methods following polymorphisms carbon metabolism genes genotyped mthfr mthfd mtrr bhmt broad panel metabolic parameters including body mass index waist circumference total cholesterol low high density lipoproteins triglycerides homocysteine folate vitamin determined results significant effect interaction mthfr polymorphism time body mass index waist circumference allelic genotype analyses indeed patients mthfr genotype higher increase body mass index waist circumference compared corresponding genotypes mthfr allele carriers genotypes addition patients mthfr genotype higher waist circumference time points similarly patients mthfr genotype higher body mass index time points effect significant correction multiple testing conclusions results indicate mthfr polymorphism may predict antipsychotic induced weight gain effects mthfr polymorphism might different initial exposure antipsychotics compared long term perspective
evidence exposure media violence causes later aggression derives largely observational nonexperimental studies augmented short term experimental studies authors review difficulties causal inference observational longitudinal data examine extent seem relevant empirical work exposure televised violence published date present reanalysis data especially influential study address one serious limitations existing analyses conclude data give evidence likely although certainly causal connection exposure televised violence adult aggression authors close brief discussion policy interventions designed reduce exposure violent
high performance license plate recognition system lprs proposed work proposed lprs composed following three main stages plate region determination character segmentation iii character recognition plate region determination stage image enhanced image processing algorithms increase system performance rectangular license plate region obtained using edge based image processing methods binarized image help skew correction plate region prepared character segmentation stage characters separated using vertical projections plate region segmented characters prepared character recognition stage thinning process character recognition stage three layer feedforward artificial neural network using backpropagation learning algorithm constructed characters determined
parents play important role successful implementation aac previous research indicated parents different countries varying perceptions use aac face different challenges implementation date limited information use aac children malaysia parents views use aim study explore malaysian parents perception aac experience supporting children use aac study parents children autism spectrum disorder cerebral palsy involved semi structured individual interviews qualitative content analysis used analyze interview data following analysis three themes identified impact use aac challenges faced hopes expectations participants reported use aac positive impact children faced challenges related child settings system well lack time support findings study provide insight malaysian speech therapists challenges faced parents supporting children use aac important overcome challenges ensure successful implementation aac
paper proposes robust adaptive observer class singular nonlinear non autonomous uncertain systems unstructured unknown system derivative matrices unknown bounded nonlinearities unlike many existing observers strong assumption lipschitz condition imposed recommended system augmented system constructed unknown bounds calculated online using adaptive bounding technique considering continuous nonlinear gain removes chattering may appear practical applications analysis electrical circuits estimation interaction force beating heart robotic assisted surgery moreover simple yet precise structure attained easy implement many systems significant uncertainties existence conditions standard form observer obtained terms linear matrix inequality constrained generalised sylvester equations global stability ensured finally simulation results obtained evaluate performance proposed estimator demonstrate effectiveness developed scheme
present method generates passive guaranteed stable simulations analog audio circuits electronic schematics real time issues one hand method based continuous time power balanced state space representation structured energy storing parts dissipative parts external sources hand numerical scheme especially designed preserve structure power balance state space structures define class port hamiltonian systems derivation structured system associated electronic circuit achieved automated analysis interconnection network combined dictionary models elementary component numerical scheme based combination finite differences applied state respect time variable total energy respect state combination provides discrete time version power balance set algorithms valid linear nonlinear case finally three applications increasing complexities given diode clipper common emitter bipolar junction transistor amplifier wah pedal results compared offline simulations obtained popular circuit simulator
vehicle anti collision warning system key research area vehicle safety also necessary means enhance driving safety reduce traffc accidents visual location method presented system based license plate image method realizes visual positioning help mounting points license plate time feasible robust analysis method proposed visual positioning method license plate frame image finally robust analysis determines good angles commutating rotation parameter method license plate image visual positioning time determines good angles translation parameter rotation translation transform therefore robust analysis determines positions visual positioning method high positioning accuracy robust analysis license plate vision positioning method useful analysis high positioning accuracy positions proposed license plate image visual location method combined plate mounting points research content paper beneficial driver decision making improves safety collision warning system intelligent vehicle
past decades many examples computer algebra methods applied successfully analysis construction numerical schemes including computation approximate solutions partial differential equations methods range grobner basis computations cylindrical algebraic decomposition algorithms symbolic summation integration latter used derive recurrence relations efficient evaluation high order finite element basis functions paper review recent developments
background chromosome deletion syndrome neurogenetic disorder associated fold increase schizophrenia individuals schizophrenia present social cognitive deficits putatively subserved network brain regions involved processing social cognitive information study used two tensor tractography examine white matter tracts believed underlie social brain network group young adults compared unaffected controls results results indicated relative controls participants showed significant differences several dti metrics within inferior fronto occipital fasciculus cingulum bundle thalamo frontal tract inferior longitudinal fasciculus addition participants showed significant differences scores measures social cognition including social responsiveness scale trait emotional intelligence questionnaire analyses among individuals demonstrated association dti metrics positive negative symptoms psychosis well differentiation individuals overt psychosis relative positive prodromal symptoms psychosis conclusions findings suggest white matter disruption specifically disrupted axonal coherence right inferior fronto occipital fasciculus may biomarker social cognitive difficulties psychosis individuals
paper emphasises significant role materials selection design manufacturing processes new needed products highest attainable quality performance optimum possibly lowest cost level engineering design processes set apart either material design often computer aided technological design suitable manufacturing processes review multi millennia long history human civilisation indicates significant increase level living production connected often launching new material groups properties better better adjusted real requirements customers getting sophisticated nearly day also launching technological processes relevant given reasons enable forecast future market products required properties appear market inseparably connected development materials science engineering two main priorities specified area continuous improvement existing materials technological processes development materials technological processes ensuring environment protection improving conditions extending human life paper includes also description world developmental trends area first decades century fundamental aim materials science engineering materials selection ensuring required functions application properties products manufactured tasks field science priority spheres world development determined directions activities materials science engineering ensuring achievements strategic aims developments societies include materials design computational materials science advanced analytical methods manufacturing processing nano smart biomimetic materials included concluded humanistic mission stands engineering circle especially associated materials manufacturing engineering aim make products consumer goods deciding directly level quality human life available people also mentioned current financing scientific researches especially mentioned fields science gives chance achieve modern technological development ensure prosperity societies future elsevier rights reserved
augmented reality mobile augmented reality widely used nowadays smartphone software architecture available one application develop mobile augmented reality targeted one mobile handsets device device change reason application require architect operating system handle network gps also application required install device require kind storage extra libraries developed mobile augmented reality system paper propose algorithm web based service oriented architecture mobile augmented reality system using prototype algorithm user design mobile augmented reality system application also extend services using current web services framework proposed order achieve application design using software architecture run mobile device platforms without need installation installation architecture give web based interface user kind network support gps support easily get application mobile device also framework base soa web services design according handle mobile data images audio video etc web server software architecture give application portability extensibility need installation reusability without code change code run multiple mobile devices without limitation third party design application using code extend per choice
evidence least one spatial dimension material component nanometer range effects nanosize stress concentrators nscs impurities inclusions pores cracks either eliminated significantly reduced aim paper examine evidence using atomistic simulation techniques crystalline metal identify critical dimensions effects nscs minimal even nonexistent preliminary results reported herein show single crystals subjected constant external strain rate critical dimensions larger rim since atomistic details crucial understanding material behavior scales paper points need multiscale simulations techniques presently developed identifying critical dimensions examining slow strain rates based results paper presents simulation based explanations nscs may insignificant nanoscales elsevier ltd rights reserved
split radix fast fourier transform srfft ideal candidate implementation low power fft processor lowest number arithmetic operations among fft algorithms design processors efficient addressing scheme fft data well twiddle factors required signal flow graph srfft radix fft therefore conventional address generation schemes fft data could also applied srfft however srfft irregular locations twiddle factors forbids application radix address generation methods brief presents shared memory low power srfft processor architecture show srfft computed using modified radix butterfly unit butterfly unit exploits multiplier gating technique save dynamic power expense using hardware resources addition two novel address generation algorithms trivial nontrivial twiddle factors developed simulation results show compared conventional radix shared memory implementations proposed design achieves lower power consumption computing point complex valued transform
aimoligoarticular onset juvenile idiopathic arthritis ojia characterised prevalent lower limb involvement antinuclear antibodies ana positivity high risk anterior uveitis observed ojia patients frequently present joint hypermobility investigated whether relationship ojia methodsour series consisted children ojia defined international league associations rheumatology criteria complete clinical data least years duration available clinical laboratory data collected disease onset last follow included sex age presence according beighton score disease activity presence uveitis ana treatment outcome resultsa total oligoarticular jia patients female male mean age followed average years entered study mean age disease onset years ana positive uveitis occurred present cases onset last evaluation frequent females males uveitis less frequent hypermobile children diagnosis overall disease course subjects least year follow full clinical remission rate significantly higher patients without conclusionin patients oligoarticular jia frequent healthy subjects uveitis less frequent long term outcome better
paper discusses design synthesis permanent magnet brushless pmbldc machine using finite element model work differentiates past studies following synthesis approach many designs satisfy performance criteria considered instead unique solution designer later select design based comparing parameters designs critical application motor used presented approach makes easier define constraints design synthesis problem detailed description setting based design synthesis problem starting definition design variables model machine design synthesis carried design finalized set designs satisfy performance criteria included paper proposed synthesis program demonstrated designing segmented axial torus pmbldc motor electric two wheeler
aim becoming parent precipitates changes new mothers psychological social domains previous literature focused exclusively pregnancy early postpartum parenting evolving process necessitating adaption changing circumstances extended previous literature investigate changes postpartum months occur maternal attitudes methods using childbearing attitudes questionnaire collected data mothers ratings maternal worries self efficacy mother infant bonding relationship partner interest sex women data analysed latent growth curve results results demonstrated stability maternal attitudes months postpartum different maternal attitudes affected different variables maternal worries self efficacy associated parity postpartum depression child temperament interestingly negative evaluation relationship partner associated breastfeeding status interest sex associated parity socio economic status ses depressive symptoms conclusion despite general stability different maternal attitudes related different sets variables patterns attitudes relation relevant variables discussed terms literature self efficacy gender roles important implications clinical interventions
conventional wisdom studies unconscious processing suggest sleeping choice may improve decision making although sleep shown benefit several cognitive tasks including problem solving impact everyday choices remains unclear explore effects sleeping preference based decisions among multiple options two studies individuals viewed several attributes describing set items asked select preferred item hour interval either contained sleep spent fully awake overnight period including sleep individuals showed increases positive perceptions choice set finding contrasts previous research showing sleep selectively enhances recall negative information addition increase positive recall translate greater desire purchase preferred item overall benefit choice satisfaction time day controls used confirm observed effects could explained circadian influences thus show people may feel positive choice options confident choice sleeping subjective decision discuss valence recalled choice set information may important understanding effects sleep multi attribute decision making suggest several avenues future research copyright john wiley sons ltd
green building actively promoted many countries become mainstream chinese construction industry due various reasons paper aims investigate major driving factors development reference chinese construction market twenty one factors influencing development identified literature review questionnaire survey face face interview professionals construction industry structural equation model established identify critical driving path three critical factors hierarchies result model analysis also verifies theoretical hypotheses government body biggest motivation development path coefficient high results demonstrate necessity formulation incentive policies power propaganda identify distinct government market effects induce government led development path findings provide valuable reference government body aiming promoting construction industry put forward relevant policies incentives market body understand major driving factors path making decisions
paper devoted experimental comparison two different methods ultra local model control concept first proposed technique based linear system resolution technique estimate ultra local model parameters second proposed method based linear adaptive observer allows joint estimation state unknown system parameters closed loop control implemented via adaptive pid controller order show efficiency two control strategies experimental validations carried two tank system experimental results show effectiveness robustness proposed controllers
paper conduct analysis current condition virtual reality computer graphics applications digital media interaction proposed systematic review digital media interaction modes theoretical analysis virtual reality computer graphics multimedia gateway separate control entire media interaction center core components media docking adaptation multimedia intelligent routing configuration management functions center centralized control media interaction configuration management multimedia intelligent routing basis integrate reconstruction methodology propose new perspective digital media interaction paradigm man machine interface design principles include basic principles general interface design analysis man machine interface specification type interface requirements review summarizes characteristics method well future integration multimedia system optimized construction method image representation algorithms considered
mesenchymal stem cells mscs currently exploited gene delivery systems transient situ expression cancer therapeutics alternative prevailing viral expression describe murine msc line stably expressing therapeutic protein passages yet fully maintaining msc features superior antitumoral activity hexavalent tnf related apoptosis inducing ligand trail formats advantage tumor targeted action choose expression dimeric egfr specific diabody single chain trail sctrail model bioactivity sctrail produced isolated clone msc trail revealed cell death induction colo cells treated either culture supernatants cocultured msc trail vivo therapeutic activity msc trail shown upon peritumoral injection colo xenograft tumor model best antitumor activity vitro vivo observed upon combined treatment msc trail bortezomib importantly vivo combination treatment cause apparent hepatotoxicity weight loss behavioral changes development well characterized stocks stable drug producing human msc lines potential establish standardized protocols cell based therapy broadly applicable cancer treatment
choice blindness refers finding people often misled self reported choices however little research investigated long term effects choice blindness examined whether people would detect alterations memory reports whether alterations could influence participants memories participants viewed slideshows depicting crimes either reported memories episodic details event exp identified suspect lineup exp exposed participants manipulated versions memory reports later tested memories second time results indicated majority participants failed detect misinformation exposing witnesses misleading versions memory reports caused memories change consistent reports experiments implications eyewitness memory
aimed bring developmental perspective metacognitive theory metacognitive model mcm originally developed adults however increasing number studies demonstrate mcm relevant child anxiety therefore important understand origins anxiety specific metacognitions given role experiences controlling parenting play maintaining perhaps forming anxious cognitions cognitive vulnerability focused maternal behavioral psychological control using cross sectional design danish school children years old rated levels anxiety anxiety specific metacognitions mothers controlling behavior child perceived maternal psychological control positively correlated anxiety specific metacognition positive negative worry beliefs cognitive confidence need control cognitive self consciousness child perceived autonomy granting negatively correlated metacognitions except cognitive self consciousness child perceived maternal psychological control indirectly associated anxiety via total metacognitions child perceived autonomy granting psychological control directly related anxiety given differential findings psychological control autonomy granting suggest specific types parenting behavior may related specific elements meta cognitive vulnerability findings theoretically important propose maternal psychological control environmental factor may play role development metacognitive vulnerability related anxiety potential clinical implication findings metacognitive therapy children include parental component
long noncoding rnas incrnas proved play important roles cellular processes cancer including development proliferation migration cancer cells present study demonstrated small nucleolar rna host gene snhg oncogene cell migration breast cancer expression levels snhg found frequently higher breast cancer tissues paired noncancerous tissues gain loss function studies proved snhg significantly promoted breast cancer cell migration predicted snhg competitive endogenous rna cerna transcription factor protein via competition shared mir bioinformatics analysis proved regulation using relative quantitative real time pcr qrt pcr western blot rna immunoprecipitation rip assay luciferase reporter assay addition identified positive correlation snhg breast cancer tissues furthermore demonstrated forced expression mir could partially abrogate snhg mediated increase breast cancer cells migration suggesting snhg promoted cell migration mir dependent manner taken together findings indicated snhg induces breast cancer cell migration competitively binding mir snhg serve potential therapeutic target breast cancer treatment elsevier inc rights reserved
triangle meshes common representation object field computer graphics recently found way field erosion simulation volumetric representation used prevail real life erosion scenes usually formed multiple materials reliable means material definition needed unfortunately coupling material information triangle mesh straightforward volumetric case paper proposes approach multiple material definition based space subdivision binary space partitioning bsp used simulate complex multi material scenes approach allows definition nontrivial scene composed several materials including definition gradually changing material method automated creation bsp tree input volumetric data proposed construction algorithm extracts triangle mesh intermediate product uses faces splitting planes bsp tree elsevier ltd rights reserved
direct gaze salient social cue affords rapid detection body research suggests direct gaze enhances performance memory tasks hood macrae cole davies dias developmental science nonetheless studies highlight disruptive effect direct gaze concurrent cognitive processes conty gimmig belletier george huguet cognition discrepancy raises questions effects direct gaze may concurrent memory tasks addressed topic employing change detection paradigm participants retained information color small sets agents experiment revealed despite irrelevance agents eye gaze memory task hand participants worse detecting changes agents looked directly compared agents looked away experiment showed disruptive effect relatively short lived prolonged presentation direct gaze led recovery initial disruption rather sustained disruption change detection performance present study provides first evidence direct gaze impairs visual working memory rapidly developing yet short lived effect even need attend agents gaze
electrocorticography ecog implants recently demonstrated promising results towards potential use brain computer interfaces bcis spectral changes ecog signals provide insight functional mapping sensorimotor cortex present electrocorticography ecog electroencephalography eeg processing integrated circuit epic rms noise floor intended emerging brain computer interface bci applications chip conditions signal simultaneously extracts energy four fully programmable frequency bands functionality demonstrated tuning four bands important frequency bands used ecog eeg applications alpha beta low gamma gamma measured results vivo ecog recording primary motor cortex awake monkey presented
piezoelectric bending actuators also known bimorphs characterized good dynamic properties displacements range millimeters therefore actuators used wide range applications however usage limited require supplying amplifiers output voltage rather expensive paper presents investigation results amplifiers high voltage output model piezobending actuator proposed implemented matlab simulink software order simulate behavior actuator supplied amplifiers simulation results presented compared investigation results high voltage amplifier used supplying piezoactuator influence current limitation operational amplifier actuator current tested finally low cost audio power amplifier proposed control piezobender actuator cheaper alternative high voltage amplifier investigations results presented paper elsevier ltd rights reserved
increasing evidence base suggests low bone mineral density bmd fractures associated cardiovascular disease cvd conducted systematic review meta analysis summarizing evidence low bmd fractures risk factors future cvd two independent authors searched major databases inception august longitudinal studies reporting data cvd incidence overall specific cvd bmd status fractures association low bmd fractures cvd across longitudinal studies explored calculating pooled adjusted hazard ratios hrs confidence intervals cis random effects meta analysis twenty eight studies regarding bmd fractures followed total participants median years taking higher bmd reference people low bmd increased risk developing cvd follow studies adjusting median eight confounders finding confirmed using decrease one standard deviation baseline bmd studies presence fractures baseline associated increased risk developing cvd regarding specific cvds low bmd associated increased risk developing coronary artery disease cerebrovascular conditions cvd associated death fractures baseline associated increased risk cerebrovascular conditions death due cvd conclusion low bmd fractures associated small significant increased risk cvd risk possibly death american society bone mineral research
seed dehydration normal terminal event development orthodox seeds physiologically related cessation grain dry mass accumulation crop grain yield better understanding grain dehydration evaluated hypothesis hydraulic conductance ear decreases latter stages development decrease results disruption occlusion xylem conduits whole ear rachis stem nodes hydraulic conductance percentage loss xylem conductivity measured flowering harvest ripeness bread wheat triticum aestivum recital grown controlled environments flag leaf transpiration stomatal conductance chlorophyll content grain ear water potentials also measured grain development show grain dehydration related whole plant physiology leaf senescence closely correlated hydraulic properties xylem conduits irrigating grains indeed substantial decrease rachis hydraulic conductance onset grain dehydration phase hydraulic impairment caused presence air embolism xylem conduits stern internodes rachis occlusion xylem lumens polysaccharides pectins callose results demonstrate xylem hydraulics plays key role grain maturation
context analysis injury illness data collected large international competitions provides olympic committee national governing bodies sport information best prepare future competitions research authors evaluated medical contacts provide expected level medical care sports medicine services international competitions limited objective analyze medical contact data athletes staff coaches participated pan american games guadalajara mexico using unsupervised modeling techniques identify underlying treatment patterns design descriptive epidemiology study setting pan american games patients participants total athletes males females participated pan american games main outcome measure medical data recorded injury evaluation injury treatment forms used clinicians assigned central olympic committee sport medicine clinic satellite locations operational day period pan american games used principal components analysis agglomerative clustering algorithms identify define grouped modalities lift statistics calculated within cluster subgroups results principal component analyses identified components accounting variability datasets plots principal components showed individual contacts focused treatment clusters massage paired manipulation mobilization soft tissue therapy general medical conclusions unsupervised modeling techniques useful visualizing complex treatment data provided insights improved treatment modeling athletes given ability detect clinically relevant treatment pairings large datasets unsupervised modeling considered feasible option future analyses medical contact data international competitions
band electromagnetic hybrid absorber radar cross section rcs reduction antennas proposed based design metamaterial structure coated synthesized dielectric absorber material dielectric filler based composite absorber fabricated optimizing weight percentage graphite glass microballoon powders mixed epoxy medium proposed shows minimum reflection loss ghz frequency region maximum absorption ghz proposed ultimately loaded onto wide band antenna order reduce band rcs antenna simulated experimental results show remarkable rcs reduction antenna full operating frequency range also observed antenna characteristics gain radiation pattern remain almost preserved loading antenna significant rcs reduction capability proposed shows potential applications stealth technology
paper quantifies economic benefits culture rainwater harvesting could produce case bogota study makes projections future water needs based local economy population growth determining variables water service needs also discusses appropriateness promoting water harvesting strategy manage urgent situation caused limitations climate change would provoke water supply city projected water supply needs growing population evidence need increase supply capacity drinking water localities make urban area bogota article concludes rainwater harvesting would generate significant savings water water supply costs users state
necessary condition stability class recurrent type tsk fuzzy systems presented system antecedent part indeed represented interval gaussian type fuzzy set consequent part ordinary nonlinear function system inputs proposed method first type fuzzy model established lmi based stability analysis model fully discussed two first order systems one stable one unstable two second order systems one stable one unstable considered proper case studies simulation results easily approve effectiveness proposed method
displacement ventilation systems initially developed efficient buoyant pollutant removal strategy scandinavian industrial halls following decades systems started used mechanical cooling office buildings auditoriums designing displacement ventilation systems challenging conventional overhead mixing systems system designs require simplified modeling tools existing simplified models validated using air temperature measurements performed test cells reproduce conditions exist large rooms thermally active boundary conditions lack measurements investigate performance systems occupied large rooms goal reducing knowledge gap paper presents set detailed temperature measurements two occupied large rooms recently designed systems measurements performed two recently refurbished rooms located lisbon large concert hall adjacent orchestra rehearsal room measurements subsequent analysis used assess actual performance large room state art systems addition measurements used determine modeling error three node model implemented energyplus simulating large rooms comparison simulations measurements revealed good agreement average simulation error obtained averaging error measurements temperature nodes largest deviation occurring floor level node approximate degrees average simulation error average error measurements nodes elsevier ltd rights reserved
decline body weight body mass index bmi aging major risk factor osteoporosis fracture suggesting treatment osteoporosis may affect body composition however effects treatment osteoporosis body composition well known present study aimed identify relationship raloxifene treatment body composition markers measured bone mineral density bmd body composition bone remodeling markers japanese postmenopausal women raloxifene treatment without treatment osteoporosis drug years analyzed relationship bmd bmi body weight biochemical markers mean age participants years percent changes body weight bmi significantly different women taking raloxifene taking osteoporosis drugs respectively raloxifene treatment significant independent determinant body weight bmi long term treatment raloxifene prevents age related weight loss
background overall performance particularly popular sports activity running typically influenced status musculoskeletal system level training conditioning biological structures change musculoskeletal system biomechanics especially feet ankles strongly influence biomechanics runners possibly predisposing injuries thorough understanding effects therapeutic approach focused feet biomechanics strength functionality lower limb muscles contribute adoption effective therapeutic preventive strategies runners methods design randomized prospective controlled parallel trial blind assessment designed study effects ground therapeutic approach focused foot ankle complex relates incidence running related injuries lower limbs one hundred eleven healthy long distance runners randomly assigned either control intervention group runners participate therapeutic exercise protocol foot ankle weeks directly supervised session remotely supervised sessions per week week period runners keep exercising remaining months study supervised web enabled software three times week baseline months months months runners assessed running related injuries primary outcome time occurrence first injury foot health functionality muscle trophism intrinsic foot muscle strength dynamic foot arch strain lower limb biomechanics walking running secondary outcomes discussion first randomized clinical trial protocol assess effect exercise protocol designed specifically foot ankle complex running related injuries lower limbs long distance runners intend show proposed protocol innovative effective approach decreasing incidence injuries also expect lengthening time occurrence first injury improvement foot function increase foot muscle mass strength beneficial biomechanical changes running walking year exercising
airborne laser scanning als based stand level forest inventory used finland nordic countries several years russian federation als extensively used forest inventory purposes despite long history research use lasers forest measurement dates back furthermore also generally accepted als based methodology meets official inventory requirements russian federation paper method developed finnish forest conditions applied als based forest inventory perm region russia sparse bayesian regression used als data spot satellite images field reference data estimate five forest parameters three species groups pine spruce deciduous total mean volume basal area mean tree diameter mean tree height number stems per hectare parameter estimates validated plot level stand level validation results compared results published three finnish test areas overall relative root mean square errors rmse higher forest parameters perm region finnish sites plot stand level stand level relative rmse generally decreased increasing stand size lower considered overall individual species groups
multi relational data mining mrdm proposed many methods searching patterns involve multiple tables relations relational database paper consider closed pattern mining distributed multi relational databases mrdbs since computation mrdm costly compared conventional itemset mining propose efficient methods computing closed patterns using techniques studied inductive logic programming ilp formal concept analysis fca given set local databases first compute sets closed patterns concepts using closed pattern mining algorithm tailored mrdm generate set closed patterns global database utilizing merge operator also present experimental results shows effectiveness proposed methods
introduction study compared percutaneous tibial nerve stimulation ptns versus electrical stimulation pelvic floor muscle training pfmt women overactive bladder syndrome oab materials methods women oab enrolled patients randomized two groups group women underwent pfmt group women underwent ptns results statistically significant reduction number daily micturitions episodes nocturia urge incontinence found two groups difference substantial women treated ptns voided volume increased groups quality life improved groups whereas patient perception urgency improved women treated ptns global impression improvement revealed greater satisfaction patients treated ptns conclusion study demonstrates effectiveness ptns pfmt women oab greater improvements found ptns
space time kinetics based inverse architecture method suggested analyze reactivity variations associated power excursions generic candu reactor intended provide diagnosis tools gain enhanced control thereby ensuring safe operation plant methodology analyzing data available core flux detectors extracting unknown reactivity coefficients presented proposed system uses reference model conjunction optimal estimator reference model composed state space representation space time dynamics neutron flux core based modal expansion approximation time domain optimal estimator filter investigated three different estimation techniques based recursive prediction error method rpem dual extended kalman filter dekf joint extended kalman filter jekf compared applicability estimation coolant void dynamic reactivity loss coolant accident candu reactor state equations also include characteristics detector responses thermal hydraulic models included calculations two different types detectors considered analysis prompt responsive platinum detector reactor shutdown systems delayed responsive vanadium detector flux mapping system elsevier ltd rights reserved
present work describes two dimensional finite element analyses carried study critical height embankment supported geotextile encased granular columns gec soft soil using plaxis software comprehensive numerical analyses performed increasing height embankment study influence tensile stiffness encasement compressibility thickness soft clay layer span columns order assess embankment critical height concluded diameter spacing columns parameters affecting development critical height based numerical results obtained design equation proposed estimate embankment critical height function mesh configuration column diameter spacing columns also possible compare equation developed available critical height results piled embankments concluding significant differences two
machine exposed internet today risk attacked compromised detecting attack attempts successful important securing networks servers end hosts assets well forensic analysis context focus problem evidence gathering detecting fundamental patterns network traffic related suspicious activities detecting fundamental anomalous patterns necessary solution able detect many types attacks malicious activities possible evidence gathering framework correlates multiple patterns detected thereby increasing confidence detection resulting increase accuracy decrease false positives demonstrate effectiveness framework evaluating dataset consisting normal traffic well traffic number malwares author published elsevier ltd behalf dfrws
objective evaluate place therapy fresh frozen plasma ffp esterase concentrate inh ecallantide icatibant management angiotensin converting enzyme inhibitor induced angioedema acei data sources literature search performed using pubmed august embase august references identified articles reviewed study selection data extraction consensus papers practice guidelines case reports series clinical trials meeting abstracts published english involving humans included data synthesis medications currently food drug administration approved managing acei emerging evidence suggests ffp medications approved management acute attacks hereditary angioedema another bradykinin mediated event may effective use acei positive efficacy results reported ffp inh mixed results seen ecallantide label icatibant evidence supporting use acei rapid symptom resolution minutes hours avoidance intubation tracheotomy several cases agents well tolerated acei conclusion acei typically self limiting event first line therapies include acei discontinuation observation supportive medications corticosteroids antihistamines epinephrine symptom progression life threatening may require interventions tracheotomy intubation label use ffp medications approved hereditary angioedema resulted rapid resolution symptoms avoidance intubation among agents icatibant supporting evidence incorporated practice guidelines algorithms second line agent serious life threatening ace
leader developmental efficacy one belief ability develop leadership knowledge skills theorized predict engagement success leader development conducting first empirical studies construct using cross sectional quasi longitudinal surveys across three samples consisting leaders respectively find leader developmental efficacy predicts intentions self develop leadership beyond past leader development intentions develop leader turn predicts actual implementation leader development behaviors month later examining reverse directionality observe quantity potentially quality past leader development behaviors positively related current leader developmental efficacy finally leader developmental efficacy associated increase leader efficacy leader development program implications assessing developing leader developmental efficacy prior formal programs discussed
objectives evaluate features ruptured gists factors might predictive rupture comparison cts taken prior rupture cts non ruptured gist methods forty nine patients ruptured gist fortynine patients non ruptured gist matched age gender location included clinical data including pharmacotherapy reviewed imaging features analyzed prior obtained rupture evaluated results common location ruptured gist small bowel mean size ruptured gist commonly showed wall defects eccentric necrosis lobulated shaped air density mass pneumoperitoneum peritonitis hemoperitoneum ascites twenty seven patients follow imaging received targeted therapy follow thickness tumour wall decreased increase size progression necrosis common targeted therapy newly developed ascites peritonitis hemoperitoneum common eccentric necrosis wall defects lobulated shape progression necrosis increase size decreased wall thickness targeted therapy may increase risk rupture rupture considered newly developed peritonitis hemoperitoneum ascites noted follow
neural network field many application models proposed previous analog neural network models composed operational amplifier fixed resistance difficult change connecting weight network study used analog electronic multiple sample hold circuits connecting weights describe input voltage easy change connection coefficient model works analog electronic circuits finish learning process short time model enable flexible learning however structure model one input one output network improved number unit network layer moreover suggest possibility realization hardware implementation deep learning model
diabetes chronic narcotic use negatively affect quality bowel preparation colonoscopy investigate whether narcotic use diabetes additive negative impact bowel preparation performed retrospective study patients mean age male received outpatient colonoscopies veterans affairs medical center june december collected information related demographics body mass index indications medical surgical history diabetes mellitus stroke cirrhosis dementia constipation hypothyroidism use narcotics antidepressants anxiolytics three months patients classified four groups diabetics narcotics diabetics narcotics neither diabetic using narcotics quality bowel preparation scored using boston bowel preparation scale bbps categorized either excellent bbps individual segment scoring excellent bbps multivariate logistic regression analysis performed identify combined impact narcotic use diabetes bowel preparation bowel preparation quality excellent thirty eight percent patients diabetes using narcotics adjusted achieved excellent bowel preparation compared adjusted patients narcotics adjusted diabetics patients neither condition concomitant narcotic use diabetes compounding effect quality bowel preparation prior colonoscopy
calculation formulas concrete steel utilization rate reinforcing layer deduced view underutilization reinforcing layer material composite main arch circle method calculation formulas defined load bearing capacity reinforcing layer divided ultimate bearing capacity reinforcing layer combined initial strain main arch ring reinforcement reinforcing layer section edge strain take compression zone partial reinforcing layer subjected tension compression example calculation formulas concrete utilization rate reinforcing layer divided types according height compression zone edge compressive strain reinforcing layer calculation formulas steel utilization rate reinforcing layer divided types according tension strain steel results show controlling stress strain stone arch bridge reinforcement make full use compression resistance main arch ring strength materials reduce waste materials relying engineering example calculation formulas provide theoretical basis calculation design similar reinforcement structure
neural network based cascade control system developed primary proportional integral derivative pid controller constructed new entropy based measure named centred error entropy cee index weighted combination error cross correntropy ecc criterion error entropy criterion eec proposed tune pid controller purpose introducing cee controller design ensure uncertainty tracking error minimised also peak value error probability density function controlled toward zero controller design based new performance function developed convergent conditions investigated using linearisation technique control process cee index estimated gaussian kernel function adaptive rules developed update kernel size order achieve accurate estimation cee index cascade control approach applied superheated steam temperature control simulated power plant system effectiveness strength proposed strategy discussed comparison pid controllers tuned eec ecc criterions
migraine headache affects western populations third common disease worldwide sixth terms disability triptans introduced united states new treatment managing migraine attacks use limited lack response safety concerns patients treatment options patients migraine fail tolerate triptans include switching another medication adding adjunctive medication desirable characteristics reported patients acute treatment migraine attacks include complete pain relief fast onset action pain recurrence diclofenac nonsteroidal anti inflammatory medication established effective acute treatment migraine american headache society based available evidence diclofenac potassium oral solution rapidly absorbed achieving maximal plasma concentrations min coincides rapid onset effect comparison diclofenac potassium oral solution diclofenac potassium tablets solution achieved significant reduction headache intensity beginning min compared min tablet across randomized clinical trials approximately patients pain free administration diclofenac oral solution effects maintained period diclofenac potassium oral solution well tolerated common adverse events dizziness gastrointestinal complaints incidences similar placebo serious adverse events reported clinical trials diclofenac potassium oral solution acute treatment migraine diclofenac oral solution may offer rapid sustained pain relief patients achieve pain resolution medications addition patients experience central sensitization allodynia may benefit cyclooxygenase blocking activity diclofenac needed advanced phase migraine
report case rapidly evolving neurological disease patient neuropathological lesions creutzfeldt jakob disease cjd lewy body dementia lbd chronic subcortical vascular encephalopathy meningothelial meningioma coexistence severe multiple pathologies single patient strengthens need perform accurate clinical differential diagnoses rapidly progressive dementias
notwithstanding effects classical visual system allowing image formation light acts upon several non image forming nif functions including body temperature hormonal secretions sleep wake cycle alertness cognitive performance studies shown nif functions maximally sensitive blue wavelengths comparison longer light wavelengths higher blue light sensitivity reported melatonin suppression pupillary constriction vigilance performance improvement also modulation cognitive brain functions studies investigating acute stimulating effects light brain activity execution cognitive tasks suggested brain activations progress subcortical regions involved alertness thalamus hypothalamus brainstem reaching cortical regions associated ongoing task course aging lower blue light sensitivity nif functions reported first describe neural pathways underlying effects light nif functions discuss eye cerebral mechanisms associated aging may affect nif light sensitivity thereafter report results investigations pupillary constriction cognitive brain sensitivity light course aging whereas impact light cognitive brain responses appears decrease substantially pupillary constriction seems remain intact lifespan altogether results demonstrate aging research take account diversity pathways underlying effects light specific nif functions may explain differences light sensitivity
network security situation prediction great significance use internet focus production life issues guidance model combination forecasting method paper based kalman filtering model new method network security prediction presented based theory decision entropy method kalman state equation measurement equation constructed according key attributes network security state combined decision entropy theory predict future state network security experimental results show proposed method high prediction accuracy suitable state prediction network security
image thresholding techniques considered must objects segmentation compression target recognition widely studied last decades example multilevel thresholding methods render great challenges image segmentation techniques remain computationally expensive choices threshold numbers increased therefore aim propose algorithm based bayesian theorem called honeybee mating algorithm hbma called bayesian honey bee mating algorithm bhbma notonly reduce computational time curse dimensionality also run reliably stably enhanced capability technically accomplished embedding new population initialization strategy based characteristics multi level thresholding technique pixel basedintensity images arranged lower grey levels higher ones extensive experiments shown proposed method outperformed state art algorithms empirically terms effectiveness efficiency applying complex image processing scenario automatic target recognition elsevier rights reserved
obesity associated increased risk cognitive impairment dementia recent findings contradictory possibly due methodological differences present study tries clarify inconsistencies following cognitive trajectories individuals obesity years studying effect obesity status obesity baseline versus incident obesity follow chronicity definition potential confounding age cardiovascular factors non linear associations longitudinal study years follow community based cognitively healthy individuals aged maastricht aging study memory executive function processing speed assessed baseline year follow obesity defined body mass index bmi waist circumference men women baseline persons obese bmi showed faster decline memory executive function processing speed chronic obese showed less widespread impairment regained normal weight associations across cognitive domains weaker obesity defined bmi follow developed obesity performed worse executive function baseline showed less decline compared participants normal weight yet age stratification post hoc analyses showed associations confounded age study shows association obesity cognitive decline confounded effect age rate decline future studies take account
considering ultrashort optical soliton propagation non kerr media cubic quintic nonlinear schrodinger equation raman effect studied dependent variable transformation hirota method based symbolic computation bilinear form explicit one two soliton solutions equation presented constraint parametric condition existence soliton solutions also derived propagation characteristics interaction behaviors solitons graphically shown discussed overtaking elastic interactions two solitons periodic attraction repulsion bounded states two solitons propagation parallel two solitons
backgroundpityriasis versicolor common superficial fungal disease possibility emergence resistant strains azoles difficulty differentiation hypopigmented early vitiligo encouraged evaluate efficacy topical tacrolimus calcineurin inhibitor agent proven vitro anti malassezia effect treatment generally effect induced hypopigmentation specifically objectivesto evaluate efficacy topical tacrolimus pityriasis versicolor patients methods fifty patients randomly allocated two equal groups applying either topical clotrimazol tacrolimus twice daily weeks evaluated beginning study third fifth weeks clinically mycologically direct smear resultsalthough treatments resulted global clinical mycological cure significant difference regarding mentioned aspects cure tacrolimus clotrimazole treated patients value respectively tacrolimus significant effect hypopigmentation fifth week follow value conclusionsin spite lack efficacy tacrolimus induced hypopigmentation therapeutic effect introduces tacrolimus therapeutic option especially early vitiligo among differential diagnoses without concerning aggravating effect topical corticosteroids
wireless sensor networks installed hostile areas security issues wireless sensor networks important getting secure links nodes challenging problem wsns vulnerable security attacks wired networks order protect sensitive data wsn protected using secret keys encrypt exchanged messages communicating nodes key management essential many security services confidentiality authentication symmetric asymmetric key cryptography trusted server schemes used solve problem asymmetric key cryptography increases network security increases computational memory energy overhead symmetric key cryptography provides less security efficient key management scheme trusted server schemes use key management server usually trusted infrastructure suitable sensor networks paper proposed mobile agent based key distribution makd makd mobile agents used dissemination public keys update shared keys sensor node constructs different symmetric keys neighbors communication security achieved data encryption mutual authentication keys simulation results show makd scalable less communication overhead
tubercular dactylitis rare manifestation skeletal tuberculosis paediatric population clinical diagnosis often delayed local symptoms may easily missed children constitutional features loss weight loss appetite night sweats evening rise temperature history close contact patient tuberculosis may always present parents seek treatment notice significant swelling tenderness fingers hand children radiology fine needle aspiration cytology may help establishing early diagnosis astute multidrug antitubercular therapy curative
spark ignition engine two zone simulation code used conduct systematic study effects combustion chamber wall temperature start heat release ignition timing fuel air equivalence ratio engine speed indicated mean effective pressure exhaust gas recirculation individual basis emissions spark ignition engine two zone model incorporates heat transfer blow losses used model flame traverses charge resulting burned unburned zones unburned zone contains reactants fuel air reaction constituents burned zone consists products combustion dissociation formation nitric oxide obtained using extended zeldovich nitric oxide reaction mechanism simulation program computes equilibrium thermodynamics rate limited values concentration oxides nitrogen parts per million ppm function crank angle well concentration exhaust gas stream study shows equilibrium formed immediately start combustion strong dependence temperature rises rapidly maximum value ppm declines rapidly pressure temperature fall expansion stroke final concentration value ppm results also show spark retard exhaust gas recirculation effective strategies emission control complete results study summarized conclusion
photoelectrocatalytic pec reduction chemical fuels achieved utilizing multi functionalized tio film photocathodes surfaces tio films nanoparticles introduced catch protons molecules eosin disodium salt embedded absorb solar energy four different amine ligands immobilized capture activate novel pec cells multi functionalized tio bivo films served photocathode counter electrode respectively found methanol major liquid product besides ethanol acetone detected well maximum formation rate highest selectivity methanol approximately respectively faradaic efficiencies pec cells exceed aid photoelectrons labeling experiments verify methanol carbon monoxide derived elsevier rights reserved
granite production chain high energy water intensive low resource efficiency paper focus characterizing potential environmental improvement granite production chain promoting optimization sawing technology implementation rainwater harvesting rwh material recovery wasted granite sludge environmental performance multi blade gangsaw mbgs diamond multi wire saw dmws technologies compared mean life cycle assessment results demonstrate dmws technology contribute water savings energy savings material savings per square meter polished granite tiles production resource savings contribute together reduce product environmental footprint potential rwh analyzed using plugrisost simulation software based system dynamics rwh depends relationship rainfall catchment surface tank size according industrial process water demand results demonstrate major potential satisfy system daily water requirements using rainwater stored rainwater tanks varying capacity rwh sustainable strategy industrial water cycle management comprehensive review literature reveals range technically feasible alternatives promote material recovery granite sludge ceramic industry one promising industrial endpoint avoid waste landfilling contribute mineral energy water savings product synergy could also serve starting point springboarding exchanges industrial agents becoming global extension resource efficiency elsevier ltd rights reserved
study investigated extent single mothers children atopic eczema experience disease related stress total mothers divided groups mothers living partner child atopic eczema single mothers child atopic eczema following questionnaires used assess psychological burden short stress questionnaire kurzer fragebogen zur erfassung von belastung kfb satisfaction life questionnaire fragebogen zur lebenszufriedenheit flz general depression scale allgemeine depressions skala ads questionnaire parents children atopic eczema fragebogen fur eltern von neurodermitis kranken kindern fen single mothers higher levels helplessness aggression due child scratching behaviour mothers living partner child atopic eczema single mothers children atopic eczema highest scores regarding experienced stress family lowest scores concerning general life satisfaction special care provided single mothers higher stress order teach deal scratching behaviour children
immunity plays important roles protective allergic responses nevertheless nature antigen presenting cells responsible cell differentiation remains ill defined compared nature cells responsible cell differentiation basophils attracted attention producer inducing cytokine whereas mhc class mhc expression function antigen presenting cells matters considerable controversy revisited mhc expression basophils explored functional relevance cell differentiation basophils generated vitro bone marrow cells culture plus csf displayed mhc cell surface whereas generated culture alone note mhc expressing basophils showed little transcription corresponding mhc gene csf addition culture expanded dendritic cells dcs basophils coculture basophils dcs revealed basophils acquired peptide mhc complexes dcs via cell contact dependent trogocytosis acquired complexes together enabled basophils stimulate peptide specific cells leading proliferation production indicating basophils function antigen presenting cells cell differentiation transfer mhc dcs basophils also detected draining lymph nodes mice atopic dermatitis like skin inflammation thus present study defined mechanism basophils display mhc cell surface appears reconcile discrepancies observed previous studies
present neural network implementation central components iterative reprocessing model model argues evaluation social stimuli attitudes stereotypes result stimuli hierarchy neural systems evaluation social stimuli develops changes processing network multilevel bidirectional feedback evaluation system integrates initial perceptual processing later developing semantic processing network processes stimuli individual appearance repeated iterations increasingly higher levels semantic processing time result network evaluations stimuli evolve discuss implications network number different issues involved attitudes social evaluation success network supports model framework provides new insights attitude theory
atp binding cassette abc family abcg transporters known produce multidrug resistance mdr cancer thereby limiting clinical response chemotherapy molecular modeling data indicated certain dopamine receptor antagonists significant binding affinity abcg transporter therefore vitro study determined effect receptor antagonists ngb sba mdr resulting overexpression abcg transporters receptor antagonists concentrations significantly affect viability wild type abcg overexpressing hek cells however concentrations ranging receptor antagonists ngb significantly increased efficacy anticancer drugs mitoxantrone doxorubicin abcg overexpressing mdr cells efflux studies indicated ngb concentration significantly decreased efflux rhodamine cells interestingly ngb significantly decreased expression levels abcg protein suggesting compounds inhibit function expression abcg transporters non toxic concentrations elsevier rights reserved
stabilization human cognition via feedback embedding social cultural contexts dynamic process deeply intertwined constituting sense riverbanks directing flow stream generalized consciousness different scales cultural norms social interaction synergistic individual group cognition disorders canonical failure mode atomistic cultures found ground state collapse well represented atomistic models economic interaction increasingly characterized divorced reality heterodox economists high rates psychopathic antisocial personality disorder obsessive compulsive disorder emerge culture bound syndromes particular western westernizing societies undergoing social disintegration
enormous growth penetration electric vehicles evs laid path advancements charging infrastructure connectivity charging stations essential prerequisite future adoption alleviate user range anxiety existing charging stations fail adopt power provision allocation scheduling management improve existing charging infrastructure data based real time information availability reserves charging stations could uploaded users help locate nearest charging station research article focuses interactive user application developed sql php platform allocate charging slots based estimated battery parameters uses data communication charging stations receive slot availability information proposed server based real time forecast charging infrastructure avoids waiting times scheduling management efficiently prevents halting road due battery drain proposed model implemented using low cost microcontroller system etiquette tested
paper present new robust database watermarking scheme originality stands semantic control data distortion extension quantization index modulation qim circular histograms numerical attributes semantic distortion control embedding process propose relies identification existing semantic links values attributes tuple means ontology avoid incoherent rare record occurrences may bias data interpretation betray presence watermark second time adapt qim database watermarking watermark embedding conducted modulating relative angular position circular histogram center mass one numerical attribute theoretically demonstrate robustness performance scheme common attacks tuple insertion deletion makes suitable copyright protection owner identification traitor tracing purposes verify experimentally theoretical limits within framework medical database one half million inpatient hospital stay records assumption imposed central limit theorem experimental results fit theory also compare approach two efficient schemes prove benefits
historically syndrome primary paroxysmal dyskinesias considered group disorders result ion channel dysfunction proposition primarily based discovery mutations ion channels caused episodic neurological disorders epilepsy migraine also supported frequent association paroxysmal dyskinesias epilepsy however discovery genes responsible classic forms paroxysmal dyskinesias disproved ion channel theory hand novel gene mutations implicating ion channels recently reported produce episodic movement disorders clinically similar classic paroxysmal dyskinesias review clinical pathophysiological aspects paroxysmal dyskinesias proposing pathophysiological framework according classified synaptopathies proline rich transmembrane protein myofibrillogenesis regulator gene channelopathies calcium activated potassium channel subunit alpha voltage gated sodium channel type transportopathies solute carrier family member proposal might serve explain similarities differences among various paroxysmal dyskinesias terms clinical features treatment response natural history international parkinson movement disorder society
auditory hyper reactivity common sensory perceptual abnormality interrupts behavioral adaptations autism spectrum disorders asd recently prolonged acoustic startle response asr latency hyper reactivity weak acoustic stimuli reported children asd indexes asr modulation known stable biological markers translational research adult population however little known stability indexes children thus objective study investigate stability neurophysiological asr indexes children asd typical development participants included children asd mean startle magnitudes acoustic stimuli presented increments analyzed average peak startle latency psl asr modulation habituation prepulse inhibition also analyzed startle measures examined follow period months baseline baseline follow period children asd significantly greater startle magnitudes weak stimuli prolonged psl compared controls intraclass correlation coefficients asr measures periods none asr measures differed significantly two periods results suggest prolonged psl greater startle magnitudes weak stimuli children asd might serve moderately stable neurophysiological indexes asd autism res international society autism research wiley periodicals inc autism res international society autism research wiley periodicals inc
research suggests members advantaged groups feel dehumanized groups respond aggressively little known meta dehumanization affects disadvantaged minority group members historically primary targets dehumanization examine important question context republican primaries witnessed widespread derogation dehumanization mexican immigrants muslims two initial studies document americans blatantly dehumanize mexican immigrants muslims dehumanization uniquely predicts support aggressive policies proposed republican nominees dehumanization highly associated supporting republican candidates especially donald trump two studies show climate latinos muslims united states feel heavily dehumanized predicts hostile responses including support violent versus non violent collective action unwillingness assist counterterrorism efforts results extend theorizing dehumanization suggest may cyclical self fulfilling consequences
nowadays romania centralized district heating still widely used many romanian cities heating facilities made whole system largely improper due large amounts heat leakage lack heat energy efficiency measures financial shortages limitations made worst due continuous limitation resources also due high price energy taking aspects consideration measurement management heating agent real priority power plants also heating distribution companies romania construction small efficient cogenerative plants another major issue municipalities huge trend romanian district heating industry introduce many possible solutions excellent measuring capacities paper presents human machine interface conceived authors applied case small power plant located freidorf timisoara starting computer science computer graphics thermal engineering electronics electrical engineering paper true example multidisciplinary research
background aims investigate efficacy safety three different dosages embryonated viable eggs trichuris suis tso versus placebo induction remission mildly moderately active ileocolonic uncomplicated crohn disease methods adults active randomly received six fortnightly doses tso suspension day tso tso tso placebo solution day double blind fashion weeks follow primary endpoint rate clinical remission crohn disease activity index cdai end treatment week withdrawal secondary endpoints included course clinical remission rate clinical response change cdai change markers inflammation mucosal healing physician global assessment results clinical remission week occurred tso tso tso patients respectively placebo recipients tso induced dose dependent immunological response response regarding laboratory markers inflammation secondary efficacy variables also showed advantage tso placebo treatment active administration tso result serious adverse drug reaction review non serious suspected adverse drug reactions following tso reveal safety concerns conclusions administration tso fortnightly weeks safe showed dose dependent immunological response tso dose showed clinically relevant effect placebo induction clinical remission response mildly moderately active ileocolonic
designed goal mimicking key features real hpc workloads mini apps become important tool design investigation mini app behavior provide system designers insight impact architectures programming models tools application performance mini apps also serve platform fast algorithm design space exploration allowing application developers evaluate design choices significantly redesigning application codes consequently prudent develop mini app alongside full blown application intended represent paper present cmt bone mini app compressible multiphase turbulence cmt application cmt nek developed extend physics cesar nek application code cmt bone consists computationally intensive kernels cmt nek communication operations involved nearest neighbor updates vector reductions mini app represents cmt nek mature state going forward developed parallel cmt nek application keep pace key new performance impacting changes describe kernels discuss role cmt bone played enabling interdisciplinary collaboration allowing application developers work computer scientists performance optimization current architectures performance analysis notional future systems
moral reasoning socio cognitive skill essential appropriate social functioning childhood evolves quality complexity ontogenetic development past research suggests related age socioeconomic factors well social cognitive skills executive functioning theory mind tom empathy affect recognition however contributions studied silos rather comprehensively little integration relative combined contribution skills furthermore studies addressed putative links factors childhood period skills maturation aim study explore factors predict moral maturity typically developing children males years explore potential moderating mediating role executive functions social cognition relationship age maturity identify specific contributions age socioeconomic factors social cognition using innovative visual assessment tool moral results indicate maturity correlated age inhibition verbal fluency attentional control social cognition tom affect recognition neither social cognition moderated effect age maturity however verbal fluency third order false beliefs moderating role link maturity children predicted three variables three domains age verbal fluency third order tom results contribute better understanding underpinnings childhood suggesting reducible general developmental factors age higher order skills social cognition also contribute moral maturity findings relevance typically developing clinical populations social skills may reduced well identification potential loci intervention children risk socially maladaptive behaviors
imagine agent performs tasks according different strategies goal behavioral recognition identify available strategies one used agent simply observing agent actions environmental conditions certain period time goal behavioral cloning ambitious last case learner must able build model behavior agent settings assumption learner access training set contains instances observed behavioral traces available strategy paper studies machine learning approach based probabilistic finite automata pfas capable achieving recognition cloning tasks evaluate performance pfas context simulated learning environment case virtual roomba vacuum cleaner robot compare collection machine learning approaches
objective gastrointestinal neural system emergence lewy body usually earlier clinical diagnosis parkinson motor symptoms therefore study aimed explore whether gastrointestinal tract prodromal patients patients methods paraffin embedded tissue specimens patients collected second affiliated hospital soochow university archives well tissue specimens non patients undergone surgical resection pathological sections stained immune histochemistry method positive staining aggregated alpha synuclein alpha syn phosphorylated alpha synuclein alpha syn gastrointestinal tract counted analyze distribution expression alpha syn prodromal patients diagnosis years years years results according results immunohistochemical staining syn tissue blocks positively stained respectively total tissue blocks provided prodromal patients positive staining tissue blocks control group tissue blocks collected patients tissue blocks alpha syn positive staining compared non patients control group alpha syn positive rate significantly increased pre post diagnosis patients however alpha syn groups increased significantly also positive expression rate alpha syn year group lower year year positive rate year group highest conclusions alpha syn main component lewy body nervous system gastrointestinal track may used characteristic predictive marker prevention disease
effectively analyzing treating energy related air pollution requires examining every factor pollution source end treatment paper applies index decomposition analysis whole process treatment perspective identify factors facilitating air pollution reduction across three stages source prevention process control end pipe treatment empirical research using data china jiangsu province cities reveals differences local approaches pollution prevention provincial level end pipe treatment remains primary approach control air pollution emissions indicating pattern pollute first govern later yet fundamentally reversed city level cities divided four types based approach air pollution treatment leading type process dependent type end dependent type lagging type cities using multiple control approaches reflecting comprehensive effect whole process treatment jiangsu province consider strengthening effective whole process air pollution treatment models transitioning pollution control adjusting industrial structure promoting technological progress consuming clean energy elsevier ltd rights reserved
paper presents possibilities combing public key encryption digital signature algorithms actually based different mathematical hard problems since output combination produces encrypted signed message general currently used public key algorithms computationally expensive relatively lengthy key requirement due dependency number theory therefore important show combinational protocols based different mathematical hard problem sense difficult solve combined scheme present powerful practical encryption digital signature scheme security level execution time
work focuses development accurate finite element method fem model predict reed critical frequency rcf electric motor study influence fixation base deviations numerical experimental results ideally base experimental tests needs sized way avoid deflection displacement attachment position motor order evaluate fem model influence base characteristics rcf results three testing bases used test electric motor relation masses bases mass motor nearly eight times twenty seven times ninety eight times respectively
perfluorinated chemicals pfcs act endocrine disrupting chemicals limited study effects ovarian reserve fecundability women years old without infertility followed pregnancy initially serum evaluated antimullerian hormone amh thyroid hormones thyroid stimulating hormone tsh thyroxine free thyroxine triiodothyronine pfcs perfluorooctanoate pfoa perfluorooctane sulfonate pfos perfluorononanoic acid pfna perfluorohexanesulfonic acid pfhxs bivariate analyses assessed relationship thyroid hormones amh pfcs fecundability ratios determined pfc using discrete time varying cox model day specific probability model pfc levels positively correlated correlation tsh amh point estimates pfc neither strong statistically significant although increased exposure pfcs correlates thyroid hormone levels significant association fecundability ovarian reserve elsevier inc rights reserved
background use speech based data classification parkinson disease shown provide effect non invasive mode classification recent years thus increased interest speech based methods applicable parkinsonism building predictive tele diagnosis tele monitoring models one obstacles optimizing classifications reduce noise within collected speech samples thus ensuring satisfying classification accuracy stability current methods effective ability instance selection seldom examined methods study oriented classification algorithm proposed examined combines classification regression tree cart algorithm ensemble learning algorithm first cart algorithm applied selecting optimal training speech samples iteratively thereby obtaining samples high separability second ensemble learning algorithm combining random forest support vector machines svm extreme learning machine elm trained based optimized training samples lastly trained ensemble learning algorithm applied test samples classification proposed method examined based recent public dataset compared relevant algorithms verification results experimental results showed proposed algorithm obtained highest degree improved classification accuracy sensitivity compared algorithms highest accuracy ensemble learning algorithm reach especially sensitivity reach moreover proposed algorithm stable especially combining cart algorithms mean classification accuracy reach conclusion proposed method improve classification performance speech data compared relevant algorithms study reference relevant researchers
aim investigate dentin bond strength two resin ceramic materials five cements six months storage cylinders group lava ultimate espe vita enamic vita zahnfabrik cemented mid coronal dentin extracted human molars relyx ultimate espe panavia kuraray variolink ivoclar vivadent els cem saremco dental ketac cem plus espe shear bond strength sbs measured six months storage degrees humidity statistically analyzed significance level alpha sbs varied markedly lava ultimate vita enamic five cements storage either six months six months sbs highest lava ultimate cemented relyx ultimate vita enamic cemented relyx ultimate variolink lava ultimate somewhat sensitive storage vita enamic
fertility reproductive behaviour nineteenth century lutheran family city poznan characterized use made peter parish peterkirche registers upon reconstructions individual histories families based fertility assessed basis length birth intervals according order age women next age specific fertility rates women coale index marital fertility calculated seasonal rhythm marital illegitimate births reconstructed basis annual rhythm marital prenuptial conceptions characterized lutheran parish peter city poznan illegitimate births prenuptial conceptions accounted almost births respectively lack seasonality marital births noted illegitimate births contrast characterized statistically significant annual rhythm maximum noted april result conceptions summer average woman completed reproduction cycle gave birth first last child ages years respectively therefore used whole reproductive period late age birth first child associated late age marriage women average years average woman completed reproduction gave birth children average length protogenesic interval months highest fertility occurred women aged years value index proved lack birth control rather conscious birth regulation generally lutheran women poznan characterized fairly high reproductive potential
depressive episodes associated changes neurotransmission central nervous system also may lead structural changes brain neuroendocrine inflammatory immunological mechanisms aim article present new hypothesis connecting inflammatory theory depression igg food hypersensitivity leaky gut syndrome new potential pathway may mediate pathogenesis depression implies existence subsequent developmental stages overproduction zonulin triggered example gliadin activation epidermal growth factor receptor protease activated receptor causes loosening tight junction barrier increase permeability gut wall leaky gut results process allowing larger molecules would normally stay gut cross bloodstream induction igg dependent food sensitivity condition causes increased immune response consequently induces release proinflammatory cytokines turn may lead development depressive symptoms seems advisable assess intestinal permeability using marker example zonulin specific igg concentrations selected nutritional components patients depression case increased igg concentrations implementation elimination rotation diet may prove effective method reducing inflammation new paradigm pathogenesis depressive disorders linking leaky gut igg dependent food sensitivity inflammation depression promising still needs studies confirm theory
order batching picker routing problems arise warehouses items specified customer orders retrieved storage locations order batching problem includes grouping given set customer orders feasible picking orders total length picker tours minimized order calculate length picker tour sequence determined according items contained picking order picked problem known picker routing problem although quite sophisticated heuristics even efficient exact solution approaches exist picker routing problem warehouse two blocks routing problem get much attention dealing order batching problem instead order pickers assumed follow certain simple routing strategy making ways warehouse advantage approach seen fact particular single block warehouse layouts corresponding picker tours straightforward memorized easily order pickers advantage diminishes however complex multi block layouts dealt furthermore case approach may result picker tours far optimal multi block layouts integrate different routing algorithms iterated local search approach batching order demonstrate benefits solving order batching picker routing problem integrated way means numerical experiments shown paying attention picker routing problem results substantial improvement solution quality without increasing computing times
climate change high political agenda weather emerged important issue travel behavioural research urban planning various studies demonstrate profound effects weather travel behaviours limited attention paid subjective weather experiences psychological mechanisms may partially underlie effects paper integrates theoretical insights outdoor thermal comfort weather perceptions emotional experiences context travel behaviour drawing unique panel travel diary data greater rotterdam respondents netherlands paper aims investigate extent weather conditions affect transport mode choices outdoor thermal perceptions emotional travel experiences findings point observed dry calm sunny warm hot weather conditions stimulate cycling transport modes via mechanisms thermal mechanical comfort lead pleasant emotions travel overall public transport users less pleasant emotional experiences users transport modes active mode users appear weather sensitive theoretical contributions empirical findings discussed context climate change climate sensitive urban planning elsevier ltd rights reserved
background aim current study explore anti arthritic effect pinitol via assessing effect various inflammatory mediators possible mechanism action material method assessed anti arthritic effect pinitol formaldehyde cfa induced arthritic model wistar swiss albino strain rats divided groups rats received different doses pinitol indomethacin days arthritic index body weight determined regular intervals together hepatic hematological antioxidant parameters expression proinflammatory cytokines tnf inflammatory mediators cox vegf also estimated histopathological evaluation joint tissue rats docking study pinitol ptpn also carried results cfa induced model rats developed redness nodules tail front paws arthritic control group rats showed similar symptoms decreased pinitol administration body weight group rats decreased pinitol treated rats showed considerably increased body weight hematological hepatic antioxidant parameters altered pinitol dose dependent manner pinitol significantly decreased elevated concentration proinflammatory cytokines inflammatory mediators improvement histopathological condition docking study suggested pinitol efficiently interacted ptpn via arg tyr leu lys creating close interatomic hydrogen bonds hydrophobic contacts conclusions pinitol showed anti arthritic effects via reduction proinflammatory cytokines inflammatory mediators via inhibition ptpn
study examined effect hamsprint drills training programme conventional football practice warm lower limb neuromuscular control purpose built active movement extent discrimination apparatus used assess lower limb neuromuscular control footballers one professional australian football league club without vision contact point participants performed backward swing movement trials leg made judgment magnitude movement scores representing ability discriminate different movement extents calculated area player receiver operating characteristic curve constructed using non parametric signal detection theory methods participants randomized either intervention control group performed different procedures warm prior football practice sessions week period tested intervention group performed hamsprint programme drills specific improvement running technique ordination hamstring function control group performed usual warm stretching running increasingly intense football drills backward leg swing extent discrimination significantly better players following week hamsprint programme compared discrimination scores players performed usual practice warm significant improvement observed lower limb neuromuscular control movements similar late swing early stance phase running hamsprint programme therefore improve control specific aspect sensorimotor system performance may useful particularly athletes lower function levels deemed risk hamstring injury sports medicine australia published elsevier ltd rights reserved
loki patera one dramatically time variable volcanic features exhibiting episodic brightening events every years may produce global heat flow observed three brightening events adaptive optics imaging keck gemini telescopes course nights observation high cadence multi wavelength nature observations provides constraints models activity loki patera matson model loki patera overturning basaltic magma sea adapted fit observations three events particular adjust details overturn progression modify lava thermal properties include dependencies temperature porosity improve fit data preferred models find overturn front propagation velocities day corresponding resurfacing rates time intervals days successive events roughly consistent day period calculated rathbun events prior best coverage obtained brightening model fits event require lava bulk thermal conductivity best fit obtained value similar average porosity decreases cooling three events overturn front appears propagate around patera clockwise direction opposite inferred past brightening events evidence overturn may complex single propagating wave perhaps involving multiple simultaneous resurfacing waves well portions patera active even nominal bright phase ended measured intensities anomalously low loki patera viewed high emission angles suggestive topographic shadowing due raised area edge depression magma sea resides elsevier inc rights reserved
water supply pipe networks inherent uncertainties analysis parameters including nodal demands pipe friction factors reservoir heads etc lead imprecise hydraulic responses study introduces methodology based fuzzy set theory analyze network hydraulics uncertainty fuzzy approach results complex optimization problem neither single common multiobjective solve problem efficiently find extreme values nodal pressures pipe velocities novel many objective particle swarm optimization pso model developed coupled network hydraulic simulation model literature coupled model applied benchmark example real pipe network literature results compared previous methods examples manifest proposed fuzzy pso computationally efficient reliable analyzing real pipe network shows instance uncertainty pipes roughness nodal demands could averagely result uncertainty nodal pressures pipe velocities
density functional theory dft calculations applied analyze effect various solvents water dimethyl sulfoxide dmso acetonitrile ethanol pyridine chloroform carbon tetrachloride ccl intramolecular hydrogen bond anti oxidative properties apigenin molecule different polarities seven solvents adequately cover range possible environments enable informative comparisons results dft calculations solvent effects introduced using tomasi polarized continuum model pcm increasing dielectric constant environment geometry apigenin monomer planar apigenin molecule stable medium strength intramolecular hydrogen bond found apigenin molecule increasing dielectric constant environment strength intramolecular hydrogen bond enhanced besides center dot center dot center dot intramolecular hydrogen bond apigenin molecule closed shell interaction considered possess dominant character covalent interactions different environments solvents induce significant changes enthalpies charged species apigenin thus preferred thermodynamically mechanism anti oxidative progress apigenin altered solvents anti oxidative progress hydrogen atom transfer hat thermodynamically dominant mechanism vacuum ccl chloroform phases sequential proton loss electron transfer splet favored pyridine ethanol acetonitrile dmso water phases elsevier ltd rights reserved
introduction targeted therapies caused paradigm shift treatment metastatic clear cell renal cell carcinoma rcc hypothesized determining differential kinase activity primary metastatic tumor sites may identify critical drivers progression relevant therapeutic targets metastatic disease kinomic profiling performed primary tumor metastatic tumor deposits utilizing peptide substrate microarray detect relative tyrosine phosphorylation activity pharmacologic genetic loss function experiments used assess biologic significance top scoring kinase vitro vivo tumor phenotypes kinomics identified peptides increased tyrosine phosphorylation metastases significantly altered based peptides bioinformatics analyses identified several candidate kinases activated metastases compared primary tumors highest ranked upstream kinase focal adhesion kinase fak rcc lines demonstrate evidence elevated fak activation relative non transformed renal epithelial cells pharmacologic inhibition fak gsk suppresses vitro tumor phenotypes turn fak knockdown rcc cells suppresses vitro phenotypes vivo tumor growth collectively data demonstrate functional activation fak metastases provide preclinical rationale targeting kinase setting advanced ccrcc
progress accomplished past decade nonlinear system identification structural dynamics considerable objective present paper consolidate progress challenging community new benchmark structure exhibiting complex nonlinear dynamics proposed structure consists two offset cantilevered beams connected highly flexible element increasing forcing amplitudes system sequentially features linear behaviour localised nonlinearity associated buckling connecting element distributed nonlinearity resulting large elastic deformations across structure finite element based code time integration capabilities made available https sem orginonlinear systems imacfocus group code permits numerical simulation benchmark dynamics response arbitrary excitation signals elsevier ltd rights reserved
chronic kidney diseases social economic problem diet long recognized fundamental modulator kidney health human experimental models age dependent alterations mitochondrial function play crucial role development diseases aging mitochondrial disorders observed experimental models kidney failure recently beneficial dietary effect specific mixture essential amino acids eaa studied elderly subjects data collected kidney aim study assess whether daily supplementation diet eaa beginning senescence could preserve renal health used middle aged month old male wistar rats fed standard diet water libitum aged group diet added eaa per day dissolved drinking water months aged eaa group young month old rats fed standard diet months used controls mitochondrial morphology markers collagen cyt oxidase hsp grp enos inos bax bcl vegf analyzed glomeruli tubules eaa supplementation limited fibrosis increased capillary tuft area glomeruli aged rats vegf enos enhanced glomeruli peritubular space eaa supplemented diet mitochondrial cyt oxidase bcl chaperones increased distal tubules eaa group levels similar observed young group mitochondrial area density eaa intake differ young groups results suggest prolonged eaa intake could represent strategy maintaining healthy status kidney aged animals
peculiar economist twentieth century nicholas georgescu roegen gave birth many controversies since particular french language literature georgescu roegen ecological claim often considered promotion degrowth paper challenge usual interpretation conclude georgescu roegen might source inspiration degrowth defenders narrow sense cautious reading bioeconomic paradigm shows georgescu roegen stance different growth degrowth debate might accurately linked agrowth option
objectives circadian regulation human physiology behavior body temperature sleep timing depends zeitgeber light synchronizes hour day study investigated effect changing light temperature workplace kelvin sleep wake activity rest behavior methods experimental group experienced light change compared non intervention group remained environment throughout week study period january february sleep logs actimetry continuously assessed sleep wake behavior activity patterns results study period timing sleep activity free days steadily advanced parallel seasonal progression sunrise non intervention group contrast temporal pattern sleep activity experimental group remained associated constant onset work conclusion results suggest artificial blue enriched light competes natural light zeitgeber subjects working warmer light appear entrain synchronize natural dawn subjects exposed blue enriched light appear entrain office hours results confirm light dominant zeitgeber human clock efficacy depends spectral composition results also indicate blue enriched artificial light potent zeitgeber used diligence
evidence mentalisation based therapy mbt increasing relation treatment personality disorder individuals personality disorder represented inpatient forensic forensic inpatient mental health services study explores mbt within forensic setting intervention designed moderate deficits linked violence improve adaptive coping interpretative phenomenological analysis conducted interviews four patients completed mbt high secure hospital findings suggest mbt enhanced participants mentalising positive impact upon capacity manage behaviour emotions mbt enabled participants process past experiences violence develop degree empathy others led trend abstinence risk behaviours findings contribute secure inpatient perspective experience mbt mbt clinical outcomes
accurate timely traffic flow prediction crucial proactive traffic management control data driven intelligent transportation systems dits attracted great research interest last years paper propose spatial temporal weighted nearest neighbor model named stw knn general mapreduce framework distributed modeling hadoop platform enhance accuracy efficiency short term traffic flow forecasting specifically stw knn considers spatial temporal correlation weight traffic flow trend adjustment features optimize search mechanisms containing state vector proximity measure prediction function selection furthermore stw knn implemented widely adopted hadoop distributed computing platform mapreduce parallel processing paradigm parallel prediction traffic flow real time finally extensive experiments real world big taxi trajectory data stw knn compared state art prediction models including conventional nearest neighbor knn artificial neural networks anns naive bayes random forest results demonstrate proposed model superior existing models accuracy decreasing mean absolute percentage error nape value time domain even achieves accuracy improvement mapes space time domains also significantly improves efficiency scalability short term traffic flow forecasting existing approaches elsevier rights reserved
arid semi arid regions around world face water scarcity problems due lack precipitation unpredictable rainfall patterns thousands years rainwater harvesting rwh techniques applied cope water scarcity researchers used many different methodologies determining suitable sites techniques rwh however limited attention given evaluation rwh structure performance aim research design scientifically based generally applicable methodology better evaluate performance existing rwh techniques semi arid regions methodology integrates engineering biophysical socio economic criteria using analytical hierarchy process ahp supported geographic information system gis jessour tabias traditional rwh techniques oum zessar watershed south eastern tunisia used test evaluation tool fifty eight rwh locations jessr tabia three main sub catchments watershed assessed evaluated based criteria selected assessed sites received low moderate suitability scores two sites receiving high suitability scores integrated methodology highly flexible saves time costs easy adapt different regions support designers decision makers aiming improve performance existing new rwh sites
objective occurrence yeast infections humans increased species belonging genus candida still common cause infection nevertheless infections caused less common yeasts widely reported recent years main objective study assess potential less common saprophytic yeasts invade host cell essential causing systemic infections material methods various yeast isolates identified dna sequence information pcr amplified region purported saprophytic yeasts characterized internalization mammalian cells vitro staining actin conclusion identification different yeast isolates various patients revealed isolates belonged genus candida remaining isolates yeasts belonging genus candida non candida clinical isolates either yeast hyphal forms efficiently internalized human epithelial cells internalization marked process actin polymerization surrounding invading yeast uptake epithelial cells signifies traversal cell barrier yeast cells infection vivo elsevier masson sas rights reserved
petri nets name creation management pns recently introduced expressive model dynamic distributed systems whose dynamics determined tokens flow system also pure names carry one hand extension makes resulting nets strictly expressive nets exploited capture plethora interesting systems distributed systems enriched channels name passing service interaction correlation mechanisms resource constrained workflow nets explicitly account process instances hand fundamental properties like coverability termination boundedness decidable pns work one step beyond verification general properties provide decidability undecidability results model checking pns variants first order calculus recently proposed area data aware process analysis model checking problem undecidable general case decidability obtained considering different forms boundedness still give raise infinite state transition system ground framework tackle problem soundness checking workflow nets enriched explicit process instances resources notably decidability results obtained via translation data centric dynamic systems recently devised framework formal specification verification data aware business processes working full fledged relational databases constraints light results contribute cross fertilization area formal methods concurrent systems foundations data aware processes extensively investigated far
study devoted experimental validation multi type sensor placement response reconstruction method structural health monitoring long span suspension bridges method multi type sensor placement response reconstruction briefly described test bed comprising physical model updated finite element model long span suspension bridge also concisely introduced proposed method applied test bed equation motion test bed subject ground motion objective function sensor location optimization principles mode selection multi type response reconstruction established numerical study using updated model performed select sensor types numbers locations subsequently identified sensor locations practical considerations fiber bragg grating fbg sensors laser displacement transducers accelerometers installed physical bridge model finally experimental investigations conducted validate proposed method experimental results show reconstructed responses using measured responses limited number multi type sensors agree well actual bridge responses proposed method validated feasible effective monitoring structural behavior long span suspension bridges
background ultraviolet uva phototherapy increasingly used treatment morphea atopic dermatitis lupus recalcitrant dermatoses present retrospective review experience modality aim evaluate treatment response rates various dermatoses adverse effects uva phototherapy methods reviewed phototherapy notes along electronic paper case records patients treated uva phototherapy october december results total patients outcomes available treatment courses treatment data available courses period found phototherapy beneficial patients atopic dermatitis patients morphea beneficial outcome recorded six cases urticaria six seven patients treated polymorphic light eruption benefit also recorded systemic lupus erythematosus lichen sclerosus mastocytosis necrobiosis lipoidica granuloma annulare scleroderma keloids overall treatment well tolerated patients stop treatment due adverse effects limitations retrospective study control group subjective recall bias quite possible number patients followed phone conclusions data suggest ultraviolet considered treatment selected dermatoses however long term malignancy risk yet unknown
investigate soliton dynamics tapered parabolic index fibers via symbolic computation variety dispersion profiles inspect specific dispersion profile controls optical soliton means akns procedure lax pair constructed nonlinear schrodinger equation variable coefficients using obtained lax pair multi soliton solutions generated via darboux transformation technique using multi soliton solutions soliton dynamics tapered parabolic index fiber hyperbolic gaussian exponential linear profiles discussed results obtained study certain potential application construction nonlinear optical devices soliton control results obtained study certain value studies propagation application soliton tapered parabolic index fiber dispersion managed fiber system
objective study association knowledge levonorgestrel emergency contraception lng risk ectopic pregnancy following lng failure methods study included women visited hospital lng failure intrauterine pregnancy iup recruited group iup group respectively participants interviewed face face using standardized questionnaire main outcome measures pearson chi square tests test used compare sociodemographic characteristics reproductive gynecological history surgical history previous contraceptive experience answers questions concerning knowledge lng results gave incorrect answers question regarding basic mechanism specific method levonorgestrel emergency contraceptive pills lng ecps higher risk lng failure women strictly follow instructions advice healthcare professionals likely subsequently experience women lng failure reported friends peers internet main sources information difference observed regard sources knowledge lng conclusions results illustrate importance strictly following doctor guidance drug instructions using lng ecps media used disseminate information responsible pharmacy staff receive regular educational training sessions regard authors pharmacoepidemiology drug safety published john wiley sons ltd
transformation constraint logic programs clp programs shown effective methodology verifying properties imperative programs following methodology encode negation partial correctness property imperative program progas predicate incorrect defined clp program show prog correct transforming empty program thus incorrect hold application semantics preserving transformation rules also show prog incorrect transforming program fact incorrect thus incorrect hold transformation rules perform replacements constraints based properties data structures manipulated program prog paper show constraint handling rules chr suitable formalism representing applying constraint replacements transformation clp programs particular consider programs thatmanipulate integer arrays present chr encoding constraint replacement strategy based theory arrays also propose novel generalization strategy constraints integer arrays combines chr constraint replacements various generalization operators integer constraints widening convex hull generalization controlled additional constraints relate variable identifiers imperative program prog clp representation values method presented paper implemented demonstrated effectiveness set benchmark programs taken literature
repowering already installed wind farms considered one promising cost effective short term strategies scale wind capacity study apply markowitz mean variance portfolio optimization theory explore alternative repowering actions spain efficient portfolios direct outcome optimization offer optimal repowering alternatives current wind farm generation mixes deliver highest possible average power output yield given level supply risk different repowering scenarios considered paper range full restructuring existing wind generation mix restricting certain amounts percentage uprating reference region results show depending configuration portfolio optimization problem hourly fluctuations aggregate power supply reduced much retaining current level energy productivity addition level energy supply risk experienced existing portfolio spanish wind farms derive efficient mixes boost productivity work aims providing valuable insight energy policy making direction optimally repowering future renewable generation elsevier ltd rights reserved
ultra saturation phenomenon one transient phenomena may lead false trip power transformer differential protection energization loaded power transformer paper presents first model loaded three phase power transformer using combining magnetic electrical circuits new algorithm presented control unusual false trip three phase power transformer differential protection due ultra saturation phenomenon based discrete wavelet transform dwt clarke transform algorithm transient phenomena three phase power transformer including magnetic inrush current ultra saturation phenomenon external internal faults power transformer simulated distinguish phenomena appropriate criteria using clarke transform dwt use energy coefficients standard deviation coefficients presented also model ultra saturation phenomenon nonlinear characteristic magnetic core effect saturation current transformers taken account assumed load transformer resistive inductive load results show control ultra saturation phenomenon necessary preventing false trip differential protection elsevier ltd rights reserved
paper investigates rise policy community china renewable energy sectors decade spectacular expansion wind solar energy industries comprises government industrial actors taking shape china main finding research influential corporations leading wind turbine solar panel manufacturers state owned electricity utility companies played important role renewable energy policy process framing strategic preferences policy priority negotiating coordinating state actors central local level therefore china climate governance domain instead traditional perception state led governance mode state officers often believed crucial actors steer climate related policies study reveals government autonomy policy process increasingly constrained rising industrial interest groups possess considerable resources institutional power china renewable energy policy subsystem
alteration gut microbiota involved several chronic inflammatory autoimmune diseases including rheumatoid arthritis gut microbial pro arthritogenic profiles hypothesized intestinal inflammation may involved spondyloarthropathies subset patients affected juvenile idiopathic arthritis jia common chronic rheumatic disease childhood compared fecal microbiota composition jia patients healthy subjects evaluating differences microbial profiles sub categories jia enthesitis related arthritis jia era inflammation entheses occurs polyarticular jia non enthesitis related arthritis jia nera taxon level analysis discovered alteration fecal microbiota components could involved subclinical gut inflammation promotion joint inflammation observed abundance ruminococcaceae jia categories reduction clostridiaceae peptostreptococcaceae jia era increase veillonellaceae jia nera respectively compared among relevant genera found increase clostridium cluster xivb involved colitis arthritis jia era patients compared trend decrease faecalibacterium known anti inflammatory properties jia nera compared jia era differential abundant taxa identified jia patients hla allele including bilophila clostridium cluster xivb oscillibacter parvimonas prediction analysis metabolic functions showed jia era metagenome differentially enriched bacterial functions related cell motility chemotaxis suggesting selection potential virulence traits also discovered differential microbial profiles intra group variability among active disease remission suggesting instability microbial ecosystem autoimmune diseases respect healthy status similarly chronic autoimmune inflammatory diseases different microbial profiles observed among different jia subgroups compared potential functional acquisition related migration could promote inflammation contribute disease pathogenesis
purpose study develop soft tactile sensor realize simultaneous measurements surface shape texture examine possibility tactile sensor based ionic polymer metal composite ipmc tracing measured object ipmc film surface shape estimated displacement film surface texture estimated vibration film method estimation displacement already developed paper preliminary test estimation roughness surface texture conducted rubbing waterproof abrasive papers ipmc film output signals processed offline pattern classifications based frequency analysis investigated differences ratio frequency component signals detected several kinds abrasive papers
look back skeletal radiology reveals sizable number publications significantly advanced state knowledge diseases musculoskeletal system review summarizes content intriguing papers year
present radio frequency based approach gesture detection recognition using textile versions common transmission lines used microwave circuits approach allows easy fabrication input swatches detect continuum finger positions similarly basic gestures using single measurement line demonstrate swatches perform gesture detection thin layers cloth weatherproofed providing high level versatility present types approaches additionally using small convolutional neural networks low level gestures identified high level accuracy using small inexpensive microcontroller allowing intelligent fabric reports gestures interest rather simple sensor requiring constant surveillance external computing device resulting textile smart composite applications controlling wearable devices providing simple eyes free mechanism input simple gestures
conduct disorder prior age identifies subgroup men severe mental illness smi present high risk violence persists across life span present study examined male violent offenders smi forensic hospital spain comparing smi without smi hcr pcl violent offenders smi obtained higher hcr pcl total scores much higher factor scores compared without prior men smi present challenge forensic psychiatric services
modern automatic test equipment unusual multiple computers making single system one issue multiple computers requirement computer disk drive associated operating system becomes issue environments require periods processing system must cleared prior moving one operating state another process become even complicated fact computers may installed places readily accessible quick turnaround addition computers require additional disk drives support operation mode order reduce complexity periods processing scheme diskless operation used allow multiple computers share single disk drive master computer paper describe method handle complex scenario particular instance several computers hosted running multiple operating systems one main computer hard drive allows quick reliable periods processing performed maintaining acceptable performance advent cheap solid state disk drives fast intelligent managed switches performance overall system actually impacted much modern operating systems tools provide capability implement diskless nodes fairly straightforward manner technology new means older ate used sun computers diskless configuration modern technology makes easy implement provides performance close enough disk based system effective solution addition removing extra disks periods processing time reduced margin error completing conversion reduced one drive
statins hypocholesterolemic drugs prescribed patients increased risk cardiovascular cerebrovascular complications ezetimibe atheroprotective activity inhibition expression vascular adhesion molecule vascular marker infiltration mononuclear leukocytes ezetimibe reduces amount chemoattractant protein available monocytes macrophages alters activity nuclear factor kappa leukocytes mechanisms action statins complement ezetimibe previous studies demonstrated combination statins ezetimibe beneficial effects including antiinflammatory activity present study evaluated effects monotherapy ezetimibe simvastatin compared ezetimibe simvastatin combined evolution inflammatory response rat model complete freund adjuvant induced arthritis animals treated ezetimibe simvastatin ezetimibe simvastatin days analyzed leukocyte rolling behavior leukocyte adhesion endothelium number leukocytes recruited knee joint cavity concentration cytokines involved inflammatory response data analyzed using paired tests analysis variance followed bonferroni post hoc test treatments reduced leukocyte rolling behavior leukocyte adhesion monotherapies change number leukocytes recruited knee joint cavity whereas ezetimibe simvastatin combination significantly reduced parameter treatments reduced levels proinflammatory cytokines increased levels antiinflammatory cytokine indicating antiinflammatory properties drugs experimental model inflammation
american flag powerful symbol campaigns seek harness electoral gain flag benefits may elusive appear begin presenting content analysis flag prevalence presidential campaign ads suggests candidates saw flags advantageous two experiments set campaign later study prospective candidates find flag exposure provides modest consistent benefits republican candidates among voters high symbolic patriotism racial prejudice republican identification effects arise regardless candidate appears flag taken together results speak power limitations american flag electioneering beyond practical implications campaigns studies emphasize heterogeneity citizens reactions visual political symbols highlight potent links symbolic attitudes nation flag
cacao beans theobroma cacao abundant source polyphenols particularly flavonoids previous studies demonstrated cacao flavanols decrease pro inflammatory cytokines resulting alleviation allergic symptoms sought investigate effects cacao extract dermatophagoides farinae extract dfe induced atopic dermatitis like symptoms attenuated dfe induced like symptoms assessed skin lesion analyses dermatitis score skin thickness histopathological analysis revealed suppressed dfe induced immune cell infiltration skin observations occurred concomitantly downregulation inflammatory markers including serum immunoglobulin chemokine thymus activation regulated chemokine macrophage derived chemokine well skin derived cytokines interleukin interferon gamma also significantly alleviated transepidermal water loss increased skin hydration results suggest natural phytochemical rich food potential therapeutic efficacy treatment published elsevier ltd
due high power density high overall efficiency permanent magnet excited synchronous machines beneficial applied traction drives full electric hybrid electric vehicles limited installation space improve performance additional flux barriers inserted rotor machine paper effects different flux barrier positions sizes systematically studied command variables improvement average torque torque ripple total harmonic distortion back emf iron losses efficiency
background world health organization disability assessment schedule whodas adapted validated several cultures data performance african context lacking aim study evaluate validity psychometric properties whodas among people severe mental disorders smd caregivers rural african setting methods content validity item whodas assessed using free listing pile sorting community members cognitive interviewing conducted people smd caregivers assess comprehensibility convergent validity sensitivity change evaluated facility based cohort study new acutely relapsed cases people smd caregivers consecutively recruited psychiatric clinic repeat assessment conducted sub sample weeks confirmatory factor analysis used evaluate construct validity people smd caregivers results internal consistency items overall scale domain ranged good alpha excellent alpha scores whodas correlated highly locally developed measure functioning moderately clinical symptom severity whodas sensitive treatment changes effect size hypothesized six sub scales loaded highly onto general disability factor item loaded significantly onto respective domains factor loadings item one factor model brief version whodas item also high item scales goodness fit indices close outside recommended ranges caregiver data item versions similar psychometric properties higher mean values better responsiveness change conclusions study showed item versions whodas acceptable validity psychometric properties used cross cultural measure however careful rigorous adaptation required rural african settings
litigation faced nfl called better prevention understanding concussions sports injuries achieve sports officials turned wireless sensor networks wsns form helmet sensors automatically report harmful injuries attendants sidelines approach provides players greater assurance safety faster response injuries security weaknesses wsns must addressed systems recently developed also highly resource constrained may easily manipulated looking gain information players form passive attack even attempting remove game sending false reports form active attack prevent attacks propose system uses modification aes ccm protocol well novel attack detection system uses probabilistic methods report harmful behavior user system power usage due injury reports compared probability model based past research recorded likelihood injury positions played professional football system offers many advantages conventional cryptography lightweight approach costs resources individual helmet sensors need send simple power reports central base station uses grid power conduct security analysis provided detail paper describes problem greater detail section details system architecture section explains aes ccm protocol explanation probabilistic approach followed security analysis compares approach several approaches found literature finally conclusion
paper describes computational approach analyzing visualizing aesthetics color perspective color theory study grounded works johannes itten one remarkable theorists color aesthetics focus lies computational analysis specific aspect color usage paintings namely modulation therefore propose three dimensional color palette visualization chromatic information image hue saturation lightness space using proposed palette derive set simple hue specific descriptors color modulation experimental results involve selection digital reproductions paintings discussed extensively itten show proposed modulation measures yield results consistent itten comments explanations future work involves exploration proposed color palette terms ability discriminate different artists painting styles spie
conduct fractional integration cointegration study several kenyan electricity price series order determine whether signs persistence mean reversion eventually discovered features considered relevant considering possibilities shocks affecting energy market kenya recently subjected major debate conclude electricity prices kenya contain unit roots implying permanent shocks lasting forever among factors affecting electricity prices find oil prices interest rates significant positive effects electricity based fact series long run relationships examined means fractional cointegration recently introduced fcvar model implemented results showing series study fractionally cointegrated oil price shocks affecting electricity prices elsevier ltd rights reserved
study examined prevalence recording posting illegal material among young adult undergraduates aged relationship frequency behavior social media use antisocial personality disorder aspd borderline personality disorder bpd overall sample posted illegal activity underage drinking lewd behavior illegal activity recorded present someone else recorded lewd illegal activity prevalence rates higher among used social media excessively met criteria aspd bpd however logistic regression analyses social media use aspd emerged unique predictors posting recording illegal material thus appear least two separate routes recording posting illegal material one fairly innocuous route excessive use social media may desensitize individuals hinder ability apply appropriate filters another ominous route pervasive psychological disorder aspd associated lifelong recklessness impulsivity lack empathy either route education lifelong ramifications digital media imperative elsevier ltd rights reserved
learning ability one distinctive characteristics make humans social creatures numerous research found individuals learn different ways every student different individual learning style instructors understand learning differences students better chances success civil engineering education therefore determining learning styles civil engineering students important factor academic success research reported paper aims explore learning styles civil engineering students turkey correlate learning styles success construction management courses gender age type university year engineering study data collected using kolb learning style inventory civil engineering students undergraduate programs four different universities questionnaire administered students direct contact items data collected end research reported paper revealed correlation learning styles management success age year civil engineering education type university gender american society civil engineers
addition improving sexual function testosterone reported beneficial effects ameliorating lower urinary tract symptoms increasing bladder capacity compliance decreasing bladder pressure however cellular mechanisms testosterone regulates detrusor smooth muscle dsm excitability elucidated used amphotericin perforated whole cell patch clamp single channel recordings inside excised membrane patches investigate regulatory role testosterone guinea pig dsm excitability testosterone significantly increased depolarization induced whole cell outward currents dsm cells selective pharmacological inhibition large conductance voltage activated channels paxilline completely abolished stimulatory effect testosterone suggesting mechanism involving channels holding potential dsm cells exhibited transient currents tbkcs testosterone significantly increased tbkc activity dsm cells current clamp mode testosterone significantly hyperpolarized dsm cell resting membrane potential increased spontaneous transient hyperpolarizations testosterone rapidly increased single channel open probability inside excised membrane patches dsm cells clearly suggesting direct channel activation via non genomic mechanism live cell imaging showed testosterone caused decrease global intracellular concentration consistent testosterone induced membrane hyperpolarization conclusion data provide compelling mechanistic evidence physiological conditions testosterone nanomolar concentrations directly activates channels dsm cells independent genomic testosterone receptors thus regulates dsm excitability
micro ring resonators important devices applicable optical filtering phenomena paper provides detailed description general characteristics serially coupled multiple ring resonator smrr identical perimeters coupling coefficients provides pass band characteristics flatter top paper includes concept masons gain formula application order analyze transfer characteristics single multiple ring resonator structures graphical approach provides fast derivation transfer function smrr results properly verified matlab
light use efficiency lue models offer effective way regional gross primary productivity gpp estimation however lue easily determined landscape level due complexity dependence various environmental factors one possible strategy avoid requirement assessing environmental stressors using photochemical reflectance index pri determine lue via epoxidation state xanthophyll cycle integration measurements gpp models could lead realistic gpp estimates landscape level conventional one leaf lue models however seem less suitable integration remote sensing observations optically derived estimates dependent shadow fraction viewed given time utilize two leaf lue lue model parameterize lue multiangle pri observations compare mod approach significant relationships found lue lue luesun lueshaded pri pri prisun prishaded day time steps similarly values relationships modeled gpp observed gpp derived measurements gpp lue mod deciduous forest lue mod evergreen forest eight day periods well lue mod deciduous forest lue mod evergreen forest day periods results relevant planning potential future satellite missions help constrain existing gpp models using remotely sensed data observations likely affected canopy shading effects time observation
high energy physics hep experiments lhc collider cern among first scientific communities high computing requirements nowadays researchers scientific domains need similar computational power storage capacity solution hep experiments found form computational grid distributed computing infrastructure integrating large number computing centers based commodity hardware infrastructures well suited high throughput applications used analysis large volumes data trivial parallelization multiple independent execution threads advanced applications hep scientific domains exploit complex parallelization techniques using multiple interacting execution threads growing number high performance computing hpc centers supercomputers support mode operation one software toolkits developed building distributed computing systems dirac interware allows seamless integration computing storage resources based different technologies single coherent system product successful solve problems large hep experiments upgraded order offer general purpose solution dirac interware help including also hpc centers common federation achieve similar goals computational grids however integration hpc centers imposes certain requirements internal organization external connectivity presenting complex design problem distributed infrastructure including supercomputers planned construction applied inter disciplinary large scale problems modern science technology
ever increasing size complexity data sets create challenges potential tradeoffs accuracy speed learning algorithms paper offers progress fronts presents mechanism train unsupervised learning features learned one layer improve performance speed accuracy features learned unsupervised feature learning ufl algorithm features trained fast radial basis function rbf extreme learning machine elm exploiting massive parallel computing attribute modern graphics processing unit customized compute unified device architecture cuda kernel developed speed computing rbf kernel elm results tested canadian institute advanced research mixed national institute standards technology data sets confirm ufl rbf elm achieves high accuracy cuda implementation times faster cpu naive parallel approach
modelling simulation essential parts study dynamic systems behaviours nuclear engineering modelling simulation important assess expected results experiment actual experiment conducted design nuclear facilities education modelling give insight dynamic systems processes nuclear processes described ordinary partial differential equations efforts expended solve equations using analytical numerical solutions consume time distract attention objectives modelling paper presents use simulink matlab toolbox software widely used control engineering modelling platform study nuclear processes including nuclear reactor behaviours starting describing equations simulink models heat transfer radionuclide decay process delayed neutrons effect reactor point kinetic equations delayed neutron groups effect temperature feedback used examples
achieve proper bonding pavement layers necessary spread precise amount tack coat several laboratory tests effectiveness newly designed device control tack coat dosage applied site studied influential variables surface macro texture amount tack coat applied negligible influence emulsion type according results obtained geotextile absorbs higher percentages emulsion samples bituminous mixtures lower surface macro texture values acd lowest percentages absorbed emulsion obtained samples higher surface macro texture values bbtma emulsion percentage absorbed geotextile directly related quantity emulsion charge bond layers elsevier ltd rights reserved
novel antifungals high demand growing resistance antifungals currently use particular opportunistic fungal infections caused candida spp rise infections genus accounting severe fungal infections following chemotherapy implantation procedures patients hiv aids series simple aurone analogs synthesized screened antifungal activity versus candida spp several compounds displayed activity two values three species candida one compounds tested also exhibits anti biofilm activity mid maturation growth elsevier ltd rights reserved
background purpose despite overwhelming evidence benefits anticoagulation patients brain ischemia atrial fibrillation vast underuse reported methods use anticoagulation secondary stroke prevention assessed national acute stroke israeli survey registry nasis hospitalized patients atrial fibrillation acute brain ischemia logistic regression analysis performed evaluate effects clinical covariates anticoagulation therapy discharge anticoagulation use time assessed subgroups patients identified barriers anticoagulation utilization results survivors acute brain ischemia atrial fibrillation mean age years female proportion patients discharged anticoagulation increased among without perceived contraindications older age greater stroke severity earlier registry period presence contraindications independent predictors withholding therapy increased anticoagulation use years observed even patients barriers anticoagulation use including patients potential contraindications conclusions survivors acute brain ischemia atrial fibrillation observed substantial increase anticoagulation utilization within less decade change mainly driven greater utilization anticoagulation subgroups traditional clinical barriers anticoagulation use indicating shift physicians perceptions risk benefit ratio anticoagulation
fishing line combined shape memory alloy sma form novel artificial muscle actuators low cost lightweight soft applied bionic wearable rehabilitation robots reduce system weight cost increase power weight ratio offer safer physical human robot interaction however actuators possess several disadvantages example fishing line based actuators possess low strength complex drive sma possesses low percentage contraction high hysteresis paper presents novel artificial actuator known sma fishing line made fishing line sma twisted coiled together driven directly electrical voltage output force reach drive voltage percentage contraction driven voltage load antagonistic bionic joint driven novel sma fishingline actuators presented based extended unparallel prandtl ishlinskii eupi model hysteresis behavior established error ratio eupi model determined joule heat model sma fishing line also presented maximum error established model based accurate hysteresis model composite pid controller consisting pid integral inverse compensator proposed performance compared traditional pid controller simulations experimentation results show composite pid controller possesses higher control precision basic pid feasible implementation sma fishing line driven antagonistic bionic joint
purpose immune mediated rheumatic diseases imrds persistence treatment may used surrogate marker long term treatment success previous comparisons persistence tumor necrosis factor alpha inhibitors tnfis paucity data subcutaneous golimumab identified aim study conduct systematic review persistence golimumab clinical practice contextualize data five year persistence estimates long term open label extension ole trials tnfis imrds patients methods pubmed embase medline conference proceedings european league rheumatism eular american college rheumatology acr international society pharmacoeconomics outcomes research ispor searched studies patients treated golimumab imrd included reported data persistence golimumab results available references identified searches studies total patients met inclusion criteria furthermore nine ole trials available among included studies clinical practice six months one year two years three years proportion patients persistent treatment ranged respectively four studies included comparisons biologics golimumab either statistically noninferior statistically superior treatments observation supported indirect comparisons unadjusted point estimates ole trials conclusion data reviewed study indicate golimumab may higher persistence tnfis notion supported indirect comparisons persistence data oles randomized controlled trials rcts furthermore study suggests persistence may lower biologic experienced compared biologic naive patients higher axial spondyloarthritis compared rheumatoid arthritis psoriatic arthritis
investigate class nonlinear biharmonic equations laplacian delta beta delta lambda element beta element lambda parameter delta div del unlike papers problem replace laplacian laplacian allow beta negative suitable assumptions obtain existence multiplicity nontrivial solutions lambda large enough proof based variational methods well gagliardo nirenberg inequality elsevier inc rights reserved
article attempt made solve load frequency control lfc problem interconnected power system network equipped classical pid controller using grey wolf optimization gwo technique initially proposed algorithm used two area interconnected non reheat thermal thermal power system study extended three realistic power systems viz two area multi units hydro thermal two area multi sources power system thermal hydro gas power plants iii three unequal area thermal power system better validation effectiveness proposed algorithm generation rate constraint grc steam turbine included system modeling dynamic stability aforesaid systems investigated presence grc controller gains optimized using gwo algorithm employing integral time multiplied absolute error itae based fitness function performance proposed gwo algorithm compared comprehensive learning particle swarm optimization clpso ensemble mutation crossover strategies parameters differential evolution epsde similar meta heuristic optimization techniques available literature similar test system moreover demonstrate robustness proposed gwo algorithm sensitivity analysis performed varying operating loading conditions system parameters range simulation results show gwo better tuning capability clpso epsde similar population based optimization techniques elsevier rights reserved
many construction injuries musculoskeletal related form sprains strains arising handling materials specified designers paper presents results study conducted among delegates attending two designing dfh seminars using questionnaire salient findings include level knowledge relative mass density materials limited designers generally consider mass density materials designing structures elements specifying materials degree designers appreciate mass density materials impact construction ergonomics designers rate knowledge mass density materials limited designers appreciate potential consideration mass density materials contribute improvement construction ergonomics conclusions include designers lack requisite knowledge relative mass density materials designers thus precluded conducting optimum design hazard identification risk assessments tertiary built environment designer education enlighten designers relative construction ergonomics recommendations include tertiary built environment designer education construction ergonomics professional associations raise level awareness relative construction ergonomics design practices include category mass density materials practice libraries
intrauterine devices iuds long acting reversible contraceptives induce number immunological biochemical changes uterine environment could affect endometrial cancer risk addressed relationship pooled analysis data collected epidemiology endometrial cancer consortium combined individual level data cohort case control studies total cases controls using multivariable logistic regression estimated pooled odds ratios pooled ors confidence intervals cis risk associated ever use type device ages first last use duration use time since last use stratified study adjusted confounders ever use iuds inversely related risk pooled compared never use reduced risk observed inert iuds pooled older age first use years pooled older age last use years pooled longer duration use years pooled recent use within year study entry pooled future studies needed assess respective roles detection biases biologic effects related foreign body responses endometrium heavier bleeding increased clearance carcinogenic cells localized hormonal changes new iuds associated endometrial cancer around world intrauterine device gaining popularity long term birth control strategy positioned embedded uterine lining iud could affect endometrial tissue study builds previous work considering type device used addition factors duration use authors found women used iud particularly inert iud less risk endometrial cancer longer device used found cancer risk decreased
demonstrated paper chaotic motion appear state variable filters common network structures dedicated analog signal processing particular two kerwin huelsman newcomb biquadratic filtering sections considered theoretical numerical experimental analysis mathematical models designed conditions evolution typical strange attractors provided corresponding largest lyapunov exponent calculated visualized function internal system parameters shape input harmonic waveform mutual connection mathematical model real lumped electronic circuit discussed detail copyright john wiley sons ltd
increasing interest thin flexible bendable devices led strong demand mechanically robust electrically reliable transparent electrodes indium doped tin oxide ito aluminium doped zinc oxide azo among employed transparent conductive oxides tco reliability flexible substrates thus received great attention however high flexibility usually achieved low thickness unfortunately compromises electrical conductivity report effects mechanical bending cycles electrical optical properties ultra thin azo azo multilayers comparison azo ito single layers whose thickness cases deposited room temperature flexible polyethylene naphthalate pen plastic substrates electrical stability films several cycles bending evaluated monitoring relative variation electrical resistance respect prepared sample structural damage induced bending detected scanning electron microscopy sem observed excellent electrical stability high flexibility azo azo sample even cycles whereas single azo ito films resistivity rapidly increases experimental results numerical simulations provide clear evidences key role played ductile interlayer provides improved robustness mechanical strain
paper presents series devices generating renewable energy marine environment recent years attracted increasing interest especially describe major types floating wind generators marine current turbines various devices based wave energy highlights key requirements considered point view control engineering considering objectives achieving economic viability view stability reliability availability particularly aggressive marine environment maintenance operations particularly costly
episodic counterfactuals imagined events could happened happen person past imagined past events important aspects mental life affecting emotions decisions behaviors however studies examining phenomenological characteristics content introduced new method systematically compare self generated episodic counterfactuals self generated episodic memories future projections regard phenomenological characteristics imagery emotional valence rehearsal content reference cultural life script affected temporal distance month year years findings showed three types events differed phenomenologically first episodic memories remembered easily sensory details dominantly field perspective compared future projections episodic counterfactuals second episodic future projections positive voluntarily rehearsed central life story identity episodic memories episodic counterfactuals third episodic counterfactuals differed episodic memories future projections neither positivity bias future events enhanced sensory details past events across three event types sensory details decreased whereas importance reference cultural life script centrality increased increasing temporal distance findings show imagined events phenomenologically different memories experienced events consistent reality monitoring theory imagined future events different actual imagined past events consistent theories motivation
article reviews process dsm personality disorder proposal change developed challenged ultimately rejected dsm workgroup mandate introduce radical changes inherently fraught limited time allowed efforts undermined dissension within committee lack clearly identified scientific rationale inconsistent dialogue existing community experts nonetheless valuable steps taken establish better definition introduce dimensions identify steps needed future revisions author retrospect concluded borderline personality disorder antisocial personality disorder treated differently clinical significance empirical support specifically major remain axis secondary disorders comfortably dimensionalized belong axis
chronic myelomonocytic leukemia cmml colony forming units granulocyte macrophage cfu grow vitro absence exogenous growth factors arise abnormal clone responsible overproduction granulomonocytic cells previous vitro findings including suggest divergent molecular aberrations cmml seem converge within csf signaling pathway jak sentinel kinase pathway jak inhibition may attractive treatment approach cmml investigated vitro effects specific jak inhibitor autonomous cfu formation peripheral blood mononuclear cells patients cmml found either block strongly inhibit spontaneous cfu growth patients tested inhibitory effect dose dependent significantly pronounced compared inhibitory effect stimulated cfu growth normal individuals cmml patient splenomegaly treated jak inhibitor ruxolitinib label demonstrate spleen response disappearance constitutional symptoms associated decrease autonomous cfu formation vivo pharmacological jak inhibition may interesting approach systematically studied patients cmml
vulvovaginal candidiasis vvc opportunistic fungal infection predominantly caused candida albicans affecting significant number women reproductive age chinese medicine baofukang suppository widely used clinic antimicrobial activity therefore great interest potential antifungal drug prevention vvc evaluated cytotoxic activity baofukang suppository using vaginal epithelial cell vec line treated baofukang suppository immunocompetent cytokines chemokines infected cells statistically regulated except compared infected control cells secretion non igg also exhibited trend scanning electron microscopy results revealed albicans invade vecs induced endocytosis active penetration baofukang suppository could effectively inhibit adhesion hyphal formation proliferation well notably restore vaginal epithelial cell morphology viability enhance local immune function vecs preliminary results suggest promising antimicrobial properties baofukang suppository may efficacious antifungal therapy candidate via regulating cellular immunity axis innate immune response secretion vaginal epithelial derived igg combined effects collectively restore immune function infected vecs albicans vitro
background current categorical classification personality disorders criticized overlooking dimensional nature personality may miss sub threshold personality disturbances clinical significance aimed evaluate clinical importance conditions used simple four level dimensional categorization based severity personality disturbance methods sample consisted patients admitted mental health services underwent diagnostic assessments scid scid filled questionnaires concerning social situation childhood adversities validated tools including beck depression inventory bdi alcohol use disorders identification test audit health related quality life five item mental health index mhi patients categorized four groups according level personality disturbance personality disturbance personality difficulty one criterion less threshold one personality disorders simple personality disorder one personality disorder complex severe personality disorder two personality disorders borderline antisocial personality disorder results proportions groups follows personality disturbance personality difficulty simple personality disorder complex severe personality disorder patients personality disturbance significantly differentiated groups regarding bdi mhi scores well number axis diagnoses patients complex severe personality disorders stood worst social dysfunction related severity personality disturbance patients personality difficulty simple personality disorder prominent symptoms difficulties differences groups mostly non significant conclusions elevated severity level personality disturbance associated increase psychiatric morbidity social dysfunction diagnostically sub threshold personality difficulties clinical significance degree impairment corresponds actual personality disorders since two groups significantly differ findings also highlight complexity related use diagnostic thresholds separate personality disorders
portland cement hydrate cold climates particular conditions therefore better understanding cement hydration low temperatures would benefit cement based composites application study portland cement therefore kinetically thermodynamically simulated based simple kinetics model minimization gibbs free energy results evaluation indicate portland cement hydration impact factors include water cement ratio temperature specific surface area latter especially remarkable factor therefore increasing specific surface area appropriate level may solution speed delayed hydration due low temperatures meanwhile ratio believed controlled cold climates consideration durability thermodynamic calculation results suggest low temperature influences divided three levels irrevocable effects degrees recoverable effects degrees insignificant effects degrees portland cement additionally measured via ray diffraction thermal gravity analysis low temperature nitrogen adsorption test laboratory comparisons drawn validate simulation result
first part review nature associations alcohol use hiv aids discussed alcohol use found strongly associated incidence progression hiv aids extent association causal traditionally remained question experiments alcohol use manipulated independent variable since helped establish causal effect alcohol use intention engage condomless sex intention engage condomless sex surrogate measure actual condom use behavior linked hiv incidence infection causal chain corroborated moreover biological pathways alcohol use course hiv aids part mediated adherence antiretroviral medication second part contribution provide suggestions quantification link alcohol use hiv incidence using risk relations derived experimental data biological links alcohol use course hiv aids difficult quantify given current state knowledge except operationalization link via adherence medication based meta analyses suggested quantifications exemplified south africa
numerous tools automating various aspects software engineering developed many tools highly configurable parameters understanding parameters advanced tools often requires deep understanding complex algorithms unfortunately suboptimal parameter settings limit performance tools hinder industrial adaptation still studies address challenge tuning software engineering tools present tuner experiment framework supports finding feasible parameter settings using empirical methods framework accompanied practical guidelines use analyze experimental outcome proof concept apply tuner tune imprec recommendation system change impact analysis software system evolved two decades compared output default setting report improvement response variable reflecting recommendation accuracy moreover tuner reveals insights interaction among parameters well nonlinear effects tuner easy use thus framework potential support tuning software engineering tools academia industry copyright john wiley sons ltd
geotextiles widely used reinforced retaining wall easy measure deformation wall construction assess deformation stability reinforced retaining wall optical fiber sensor used geotextile based measurement accuracy strain sensor geotextile actual geotextile reinforced retaining wall studied using fiber sensor geotextile experimental results compared results numerical procedure employs mohr coulomb yield criterion initial stress method determines plastic displacement collapse represented distribution yield elements comparison shows numerical results good agreement corresponding measurement values result shows possibility procedure gives realistic evaluation long term deformation reinforced retaining wall
aim study investigate appearance density distribution ghrelin cells ghs ghs human stomach duodenum prenatal early postnatal development examined chromogranin ghrelin cells duodenum ghs ghs expressionin stomach duodenum immunohistochemistry embryos fetuses infants chromogranin ghrelin cells identified duodenum weeks gestation ghrelin cells detected individually clustered within base duodenal crypts villi first trimester presented separately within basal apical parts crypts villi second third trimesters ghrelin cells numerous first similar third similar trimesters gestation development ghs ghs detected weeks gestation showed highest level expression brunner gland lower parts duodenal crypts villi second trimester antrum third trimester corpus duodenum findings demonstrated first time abundant duodenal expression ghrelin cells ghrelin receptors human prenatal development indicating role ghrelin regulation growth differentiation human gastrointestinal tract elsevier inc rights reserved
recent years chchd chchd mutations reported associated broad spectrum neurodegenerative diseases including parkinson disease although conflicting results different populations present study aimed evaluate chchd chchd coding variants italian patients coding regions flanking intronic splice sites chchd chchd sequenced none cases carried chchd mutations whereas sporadic patient showed proser substitution chchd data suggest chchd chcdh mutations relevant cause italian population elsevier inc rights reserved
structure physiological state local white adipose tissue wat located underneath lesional psoriatic skin inside joints affected psoriatic arthritis play important role pathophysiology diseases wat pads associated inflammatory sites psoriasis psoriatic arthritis correspondingly dermal wat articular adipose tissue pads demonstrate inflammatory phenotypes diseases local wat inflammation could primary effect pathophysiology psoriasis leading modification local expression adipokines change structure basement membrane release keratinocytes consequent epidermal hyperproliferation psoriasis similar articular adipose tissue inflammation lead induction structural modifications synovial inflammation joints patients psoriatic arthritis
monte carlo method provide high fidelity neutronic analysis different types nuclear reactors owing advantages flexible geometry modeling use continuous energy nuclear cross sections also coupled thermal hydraulics codes consider feedbacks due effect thermal motion target nucleus known doppler effect special treatments used cross sections different temperature points traditional approach pre generated cross sections difficulty memory footprint number temperature points large target motion sampling tms method proposed developed serpent code temperature treatment based woodcock tracking paper tms method developed rmc code based ray tracking moreover doppler broadening rejection correction dbrc technique also implemented rmc consider effect thermal motion scattering kinematics pre generated technique proposed applied accelerate calculation tms method results show tms method equivalent exact cross sections dbrc tms rmc higher efficiency cases pwr htgr matter number nuclides small large elsevier ltd rights reserved
aims objectives understand parents experiences managing child postoperative pain home background recent changes children health care services often shift responsibility managing children postoperative pain parents although pain management important good postoperative outcomes challenging task families children pain often managed design qualitative study used semi structured interviews explore parents experiences managing child postoperative pain home methods participants parents typically developing year olds underwent adeno tonsillectomy experienced complications leading hospitalisation postoperative period one one interviews conducted parents within three months child surgery interviews transcribed verbatim content analysis used identify themes parents experiences results children experienced postoperative pain parents experiences managing child pain impacted balancing pros cons administering analgesic medications managing emotional psychological effects child pain well parents information needs conclusions parents information needs met yet still struggled manage child pain findings provide insight barriers make process challenging many families health care centres help support parents manage child postoperative pain home relevance clinical practice results study may aid design interventions support parents managing child postoperative pain home thus improve children experiences
paper new active element called voltage differencing inverting buffered amplifier vdiba presented using single vdiba capacitor new resistorless voltage mode first order pass filter apf proposed provides inverting non inverting outputs configuration simultaneously pole frequency filter electronically controlled means bias current internal trans conductance component matching conditions required low sensitivity addition parasitic loading effects also investigated connecting two newly introduced apfs open loop novel second order apf proposed another application proposed apf connected cascade lossy integrator closed loop design four phase quadrature oscillator theoretical results verified spice simulations using tsmc level cmos process parameters supply voltages moreover behavior proposed apf also experimentally measured using commercially available integrated circuit opa texas instruments
african americans suffer disproportionately smoking related morbidity mortality make quit attempts report less success quitting smokers tend identify strongly african american culture qualitative interviews conducted elicit perceptions toward smoking intervention content seventy one african american smokers recruited community locations participated majority stated would use cessation aids trying quit smoking despite availability free nicotine replacement acculturative stress scores significantly higher younger participants higher income higher african american acculturation predict smoking cessation intervention preference family social relationships cited reasons wanting quit reasons continuing smoke based findings interventions urban african americans address household members continuing smoke social family connections stress management cultural identification urban areas
past years guidelines developed help interviewers investigate cases alleged child sexual abuse csa studies assessed investigators abilities adhere guidelines study aimed evaluate whether investigative interviewers personal attributes related performance mock investigative interview child victim sexual abuse assessment conducted police training context total french canadian police investigators followed one week training program aimed using national institute child health human development nichd interview protocol investigators performed mock interview end training test practical competence also filled three questionnaires assessing cognitive abilities emotional intelligence personality traits interview performance positively related cognitive abilities female gender personality trait openness experience negatively related stress management level experience four regression models presented explain interview performance variance results study show personal characteristics cognitive abilities personality gender experience affect investigative interviewers performance child victim sexual abuse police training context
purpose aim study evaluate impact various factors day postoperative morbidity patients underwent colorectal surgery crs colovesical fistula cvf elective emergency settings methods patients underwent crs cvf identified american college surgeons national surgical quality improvement program database using current procedural terminology codes demographics perioperative operative factors assessed compared two groups classified according presence absence postoperative complications results five hundred twelve patients met inclusion criteria mean age years female etiology fistula diverticulitis colon cancer crohn disease one hundred fifty two procedures performed laparoscopically patients bladder intervention performed one hundred forty nine patients least one postoperative complication patients developed complication older often female hypertensive anemic preoperatively transfused class wound classification independent risk factors affecting morbidity increased age odds ratio decreased hematocrit level open approach conclusions morbidity cvf remains high lower preoperative hematocrit level increased age associated higher risk complication laparoscopic surgery may preferable possible morbidity less approach
increase workload across many organizations consequent increase occupational stress negatively affecting health workforce measuring stress human psychological dynamics difficult due subjective nature selfreporting variability within individuals advent smartphones possible monitor diverse aspects human behavior including objectively measured behavior related psychological state consequently stress used data smartphone built accelerometer detect behavior correlates subjects stress levels accelerometer sensor chosen raises fewer privacy concerns comparison location video audio recording low power consumption makes suitable embedded smaller wearable devices fitness trackers subjects two different organizations provided smartphones study lasted eight weeks conducted real working environments constraints whatsoever placed upon smartphone usage subjects reported perceived stress levels three times working hours using combination statistical models classify selfreported stress levels achieved maximum overall accuracy user specific models accuracy use similar users models relying solely data single accelerometer
neural network field many application models proposed previous analog neural network models composed operational amplifier fixed resistance difficult change connecting weight network study used analog electronic multiple sample hold circuits connecting weights describe input voltage easy change connection coefficient model works analog electronic circuits finish learning process short time model enable flexible learning however structure model includes one input one output network improved number unit network layers moreover suggest possibility realization hardware implementation deep learning model authors published elsevier
considerable research examined infants understanding evaluations social agents two questions remain unanswered first infants organize observed social relations larger structures inferring relationship two social beings based relations third party second infants reason type social relation prominent societies caregiving relation parents babies series experiments using animated events ask whether month old infants infer two babies comforted adult two adults comforted baby affiliate one another find infants make inferences make comparable inferences presented visible events voices specify peer context one adult responds another laughing adult thus infants sensitive least one aspect caregiving organize relations infants adults larger social structures elsevier rights reserved
paper present implementation block power method based spark big data processing framework approximate dominant eigenvalues eigenvectors large sparse matrix distributed computing environment take advantage graph parallel computation spark employ property graph specially defined vertex edge types represent sparse matrix associated block matrix together graph operations performed constructed property graph efficiently carry iteration decomposition steps block power method parallel numerical results markov chain application modeling stochastic luminal calcium release site provided demonstrate effectiveness scalability block power method implementation
background aim small intestinal bacterial overgrowth sibo associated gastrointestinal pathology colonoscopy endoscopic investigation could cause changes gut flora including occurrence sibo looked study effect colonoscopy preparation intubation occurrence sibo materials methods prospective study including thirty patients irritable bowel syndrome ibs diagnosed according rome iii criteria two groups designed twenty ibs patients performed colonoscopy ten ibs patients referred colonoscopy patients tested presence sibo using glucose hydrogen breath tests ghbt beginning study day patients also tested colonoscopy day week day patients performed ghbt day day results peak value expired assessed mean value calculated significant statistical differences mean values groups patients day mean level significantly decreased preparing colonoscopy patients significant statistical differences mean levels day versus day patients mean level week performing colonoscopy ppm higher obtained preparing ppm statistical significance patients showed statistical differences mean levels day versus day patients significantly lower mean level versus patients day conclusions colonoscopy produce sibo preparing colonoscopy influences level expired reduces number intestinal bacteria probably trough mechanic effect inflating air procedure performing ghbt soon colonoscopy might result false negative results ghbt
casein recognized good source bioactive peptides used production functional food study thrombin inhibitory peptides casein screened bioinformatics based sequences predicted silico enzymatic digestion trypsin identified uplc qtof mascot analysis molecular docking conducted using software discovery studio provide potential mechanism underlying thrombin inhibitory activity peptides total novel peptides thrombin inhibitory activity identified moreover fqseeqqqtedelqdk derived beta casein fragment showed remarkable sequence similarity fragment hirudin exhibited strong inhibitory activity thrombin fqseeqqqtedelqdk similar target domain lys arg thr lys lys stereo structure thrombin compared hirudin domain belongs partial structure active site thrombin pdb bvr also located exosite motif buried external surface thrombin molecule potential inhibitory activity peptide elsevier ltd rights reserved
perfectly adapted diverse environments chickweed stellaria media vill ubiquitous garden weed grows widely europe north america opposed model plants many weeds media particular poorly studied although likely contain promising components immunity novel resistance genes study first time rna seq analysis healthy infected fusarium oxysporum chickweed seedlings well novo transcriptome assembly annotation presented note research focused antimicrobial peptides amps major components plant immune system using custom software developed earlier unique putative amps pamps including defensins thionins hevein like peptides snakins alpha hairpinins ltps cysteine rich peptides novel cysteine motifs predicted furthermore changes amp expression profile response fungal infection traced addition comparison chickweed amp repertoire caryophyllaceae plants whose transcriptomes presently available made result alpha hairpinins hevein like peptides display characteristic modular structure appear specific amps distinguishing media dianthus caryophyllus silene vulgaris silene latifolia finally revealing several amps proven antimicrobial activity gives opportunity conclude presented method amp repertoire analysis reveals highly active amps playing vital role plant immunity elsevier societe francaise biochimie biologie moleculaire sfbbm rights reserved
information generated nowadays growing volume complexity representing technological challenge demands relational model databases currently offer situation stimulates use different forms storage graph databases current graph databases allow automatic database evolution provide adequate resources information organization mostly left responsibility applications access database compromising data integrity reliability goal work definition refactoring rules support management evolution graph databases adapting extending existent refactoring rules relational databases meet requirements graph databases features refactoring rules used developers graph database management tools guarantee integrity operations database evolution
sleep problems especially nightmares insomnia often accompany depression study investigated nightmares symptoms insomnia chronotype sleep duration associate seasonal affective disorder special form depression additionally noted latitude proxy photoperiod characteristics place residence affect prevalence seasonal affective disorder sleep problems study questions data finrisk study used finrisk consists random population sample finnish adults aged years collected winter finnish urban rural areas spanning latitudes degrees degrees seasonal pattern assessment questionnaire used assess symptoms seasonal affective disorder participants symptoms seasonal affective disorder significantly increased odds experiencing frequent nightmares symptoms insomnia often evening chronotypes associations latitude population size urbanicity seasonal affective disorder symptoms sleep disturbances generally significant although participants living areas bordering urban centres less sleep problems participants regions data show prevalence seasonal affective disorder affected latitude
new approach proposed improve graphical approach considering intensity coupling loss coefficients analytical derivation optical transfer functions symmetric double stage vertically coupled microring resonator optimum transmission coupling condition determined considering terms couplers intensity loss leads low insertion loss finesse band rejection ratio resonating system used optical force sensing system make benefit accuracy measurements micro nano scales sensitivity proposed force sensor terms wavelength shift limit detection proposed sensing system advantages self calibration low power consumption due low intensity elsevier ltd rights reserved
study aimed develop validate instrument assessment patient relevant benefit dermatocosmetic treatment skin care aged skin based open item collection elderly persons items patient relevant treatment goals collected expert panel selected items relevant feasible questionnaire named patient benefit index aged skin pbi instrument assesses goal importance achievement tested cognitive debriefing validated longitudinal study along dry skin area severity index dasi dermatology quality life index dlqi convergent validation criteria cognitive debriefing showed good practicability feasibility instrument significant correlation change dasi supports convergent validity pbi contrast correlation dlqi poor indicating different constructs pbi valid feasible tool patient centered assessment dermatocosmetic treatment benefit aged skin
present study investigated optimum adsorption conditions adsorption characteristics surviva lactobacillus acidophilus adsorbed attapulgite ait results single factor experiments showed optimum adsorption parameters alt concentration initial temperature degrees static experiments adsorption characteristics found experimental data fitted best pseudo secondorder kinetics langmuir isotherm models adsorption spontaneous endothermic process bacteria survival test showed microencapsulated acidophilus stored degrees days achieved highest survival rate obtained better protection simulated conditions gastric high bile salt concentrations compared free bacteria study demonstrated microencapsulation acidophilus att effective technique protection low temperature injury simulated gastrointestinal environment elsevier ltd rights reserved
overweight asthmatic children report greater symptoms normal weight asthmatics despite comparable airflow obstruction widely assumed due heightened perception respiratory effort three groups children healthy weight controls healthy weight asthmatics overweight asthmatics rated perceived respiratory effort throughout inspiratory resistive loading protocol parasternal intercostal electromyogram used objective marker respiratory load expressed relative tidal volume reported ratio baseline value neuroventilatory activity ratio nvear significant increases perception scores decreases nvear observed lowest highest resistive load higher bmi increased overall perception scores influence asthma bmi age percentile resistance perception relationships data indicating elevated overall respiratory effort overweight asthmatic children comparable responses dynamic changes load suggest greater disease burden overweight asthmatic children may due altered respiratory mechanics associated increased body mass elsevier rights reserved
hybrid electric vehicles hevs regenerative braking might effective way energy conservation however braking energy usually regenerated completely due limit motor maximum torque braking torque provided electric motor meet driver braking demand hydraulic brake system provide extra braking torque results braking energy loss therefore meaningful adjusting work point maximize regenerative energy transmission downshifting paper hev equipped automated manual transmission amt chosen study platform first simplified dynamic models hev system built process advantages amt downshifting analyzed characteristics regenerative braking obtained different gear positions different two kinds downshifting strategy proposed basis last hardware loop tests carried results show energy conservation regenerative braking process downshifting increased compared without downshifting elsevier ltd rights reserved
introduction aging age associated disorders parkinson disease often associated turning difficulties lead falls fractures valid assessment turning turning deficits specifically non standardized environments may foster specific treatment prevention consequences methods relative orientation obtained accelerometer gyroscope data sensor worn lower back used develop algorithm turning detection qualitative analysis patients controls non standardized environments algorithm validated total turns degrees extracted independent dataset patients medication conditions older adults video observation two independent clinical observers served gold standard results patients medication algorithm detected turns sensitivity specificity accuracy medication values older adults algorithm reached validation values turning magnitude difference degrees sem degrees duration difference sem yielded high correlation values gold standard overall accuracy direction turning intra class correlation clinical observers conclusion wearable sensor relative orientation based algorithm yields high agreement clinical observation detection evaluation degrees turns non standardized conditions patients older adults suggested assessment turning daily life
order make dynamic voltage restorer dvr concurrently compensate low order harmonics voltage sag eliminate influence digital control system performance propose novel double closed loop digital control strategy consisting fundamental proportional resonant control voltage loop selective harmonic control inductance current loop mainly analyse discretization effects virtual method step response method present straightforward digital design method next method design parameters fundamental selective harmonic controllers discrete domain inhibit influence sampling calculation delay etc steady state error dynamic response performance finally kva dvr prototype developed tested experimental results indicate proposed control strategy satisfies requirement voltage quality sensitive loads achieves good dynamic response performance
purpose purpose paper investigate extent green building features evident office properties lagos nigeria consequently determine degree compliance green standards country design methodology approach study purposively sampled two office properties management portfolio registered estate firms lagos data collected using physical observation properties interview two users purposively selected properties data analysed use frequency distribution percentages measures green features availability index findings result revealed low extent green features incorporation existing office properties value availability indices features falling five point scale feature relating material use conservation incorporated green feature mean score relating owner occupant education least incorporation mean score practical implications findings apparent green retrofitting may necessary nigeria due low extent green practices existing office properties also reinforcement existing government policies increased sensitisation stakeholders impact current building practices pertinent green building success nigeria originality value existing studies similar focus based developed economies stronger implementation framework exists green building besides mostly based evaluation green certified buildings using criteria study differs presents existing building sustainability practices less pronounced green property market varying architectural styles using robust criteria information provided applicable nigeria emerging economies
article solve closed form system nonlinear differential equations modelling elastica space thin flexible straight rod loaded constant thrust free end common linearizations strength materials course applicable way analyze great deformations even large linear elasticity range passing cylindrical coordinates rho theta earn tractable differential system evaluating rho elliptic function polar anomaly theta also providing elliptic integrals iii kind deformed rod centerline completely described tensile compressive load finally planar case comes degeneracy bernoulli lemniscatic integral appears
capacitance limits bandwidth engineered biological electrical circuits determines gain bandwidth product gbwp fixed gbwp bandwidth improved decreasing gain engineered circuits inductance reduces limitation shunt peaking equivalent mechanism reported biological circuits show blowfly photoreceptors voltage dependent conductance fast delayed rectifier fdr produces shunt peaking thereby increasing bandwidth without reducing gain furthermore fdr time constant close value maximizes photoreceptor gbwp reducing distortion associated creation wide band filter using model honeybee drone photoreceptor also show voltage dependent conductance produce shunt peaking argue shunt peaking may widespread graded neurons dendrites
testbed used tune assess automotive engines high dynamic scenarios need simulated testbeds require multi input multi output mimo robust control systems cooperation involving major testbed manufacturer two university laboratories therefore set paper presents control system design csd methodology developed system identification design assessment mimo robust controller testbed coupled spark ignition engine specially highlighted entire process automated simplified fractional order based mimo crone csd parameterized obtain best performance experimental results show proposed fractional order based mimo control system able improve robustness decoupling elsevier ltd rights reserved
background tumor necrosis factor inhibitors tnfi widely used systemic treatments patients psoriasis psoriatic arthritis currently exists food drug administration issued warning label tnfi rare cases new onset exacerbation central nervous system demyelinating disorders aim review update incidence tnfi induced demyelinating diseases methods pubmed database searched safety data regarding demyelinating disease secondary tnfi therapy prescribed psoriasis results clinical trials patients received treatment etanercept one reported case multiple sclerosis patients treated adalimumab cases identified patients treated infliximab one case demyelinating polyneuropathy outside clinical trials individual cases demyelinating disorders tnfi treatment reported conclusion although potential tnf blockade lead demyelination central peripheral nervous systems results present review suggest demyelinating diseases associated tnfi extremely rare tnfi recommended use patients personal history demyelinating disease however clinical vigilance individualized treatment regimen tnfi may safe use patients
paper presents new identification searching method system parameters nonlinear lcd glass handling robot system using improved real coded genetic algorithm irga well known real coded genetic algorithm rga method optimal near optimal searching technique borrows concepts biological evolutionary theory furthermore select operators rga important step affect final identified results paper three algorithm operators including self learning genetic algorithm slga adaptive real coded genetic algorithm arga terminal condition combined develop new algorithm system identification proposed algorithm compared genetic algorithms merits numerical simulations experimental results demonstrate proposed irga identification method best one feasible glass handling robot system driven permanent magnet synchronous motor pmsm
purpose examine association symptoms depression ambivalence pregnancy inner city adolescent female population methods study analyzed data urban minority adolescent females ages years presenting contraceptive initiation comprehensive free cost adolescent health center new york city cross sectional baseline data examined define relationship participants ambivalence toward pregnancy defined responses items previously used national longitudinal study adolescent health symptoms depression assessed center epidemiological studiesedepression scale controlling covariates multivariate logistic regression used identify unique contribution symptoms depression pregnancy ambivalent group results one third adolescent females self reported ambivalence pregnancy sample reported mild reported moderate severe symptoms depression controlling potentially confounding factors adolescent females reported mild symptoms depression increased odds reporting pregnancy ambivalence adjusted odds ratio confidence interval compared minimal symptoms depression conclusions substantial number adolescents despite planning initiate contraception ambivalent pregnancy reporting ambivalence likely report mild symptoms depression counseling adolescents contraception initiation clinicians aware mild symptoms depression may contribute ambivalence pregnancy society adolescent health medicine rights reserved
anemia chronic inflammation aci frequently diagnosed anemia portends independently increased morbidity poor outcome associated multiple underlying diseases pathophysiology aci multifactorial resulting effects inflammatory cytokines directly indirectly suppress erythropoiesis recent advances molecular understanding iron metabolism provide strong evidence immune mediators lead hepcidin induced hypoferremia iron sequestration decreased iron availability erythropoiesis role hepcidin ferroportin axis pathophysiology aci stimulating development new diagnostics targeted therapies review present overview rationale inflammation iron erythropoiesis related strategies currently development
cannabis sativa subspecies cannabis plant contains aromatic hydrocarbon compounds called cannabinoids delta tetrahydrocannabinol abundant cannabinoid main psychotropic constituent cannabinoids activate two types protein coupled cannabinoid receptors cannabinoid type receptor cannabinoid type receptor ongoing interest development research explore therapeutic potential cannabis delta tetrahydrocannabinol exerts biological functions gastrointestinal tract cannabis used treatment disorders abdominal pain diarrhea endocannabinoid system endogenous circulating cannabinoids performs protective activities tract presents promising therapeutic target various conditions inflammatory bowel disease especially crohn disease irritable bowel syndrome secretion motility related disorders present review sheds light role cannabis gut liver pancreas also symptoms nausea vomiting cannabinoid hyperemesis syndrome anorexia weight loss chronic abdominal pain although current literature supports use marijuana treatment digestive disorders clinical efficacy cannabis constituents various disorders remains unclear copyright wolters kluwer health inc rights reserved
breast cancer common cancer among women development modern medical science information technology medical imaging techniques increasingly important role early detection diagnosis breast cancer paper propose automated computer aided diagnosis cadx framework magnetic resonance imaging mri scheme consists ensemble several machine learning based techniques including ensemble sampling eus imbalanced data processing relief algorithm feature selection subspace method providing data diversity adaboost improving performance base classifiers extracted morphological various texture gabor features clarify feature subsets physical meaning subspaces built combining morphological features kind texture gabor feature tested proposal using manually segmented region interest roi data set contains images malignant tumors images normal tissues benign tumors proposal achieves area roc curve auc value outperforms state art breast mri cadx systems compared methods proposal significantly reduces false positive classification rate
dental teams involved child protection years brief review summarises involvement detection various types child abuse goes discuss gap proportions dental professionals suspect child abuse neglect paediatric patients refer cases potential reasons discrepancy discussed glimpse future given research may necessary tackle existing gap
adequate representation states construction intelligent agents fundamental allowing achieve satisfactory performance principally actuate competitive environment possesses high state space one particular type representation appropriate situations netfeaturemap describes means features relevant aspects inherent environment agent actuates renowned intelligent agents features manually selected certainly leads inadequate choices way main contribution paper propose new approach based association rules automatically selects features intent investigating efficacy proposal authors utilize domain checkers player agents study laboratory best performance association rules based agents proves efficacy present proposal
paper deals motion control induction motor nonlinear state equations describing dynamics machine embedded linear model rotor speed varying parameter advantage taken recent results control linear parameter varying systems thus ensuring stability independently varying parameter changes time within compact set adopted control structure consists fast inner electric loop controls stator currents outer mechanical loop generates torque acting motor shaft crucial importance design internal model controller current loop particular proved algebraically equivalent electric motor model admits lyapunov function together lyapunov derivative independent motor parameters result allows find upper bound norm youla kucera parameter ensures robust stability speed measurement errors simulations carried benchmark motor model show adopted control strategy performs well copyright john wiley sons ltd
paper presents data oriented technique designing proportional integral derivative pid controller based generalized predictive control law linear unknown systems several control design approaches model based control theory requires accurate modeling identification plant used calculate control parameters however higher order systems systems unknown time delay chemical industries thermal industries difficult model identify plant accurately last decade data oriented techniques online offline data utilized attracting considerable attention designing controllers unknown plants based input output data main feature technique study controller parameters first obtained using generalized predictive control law data oriented technique converted pid parameters practical point view proposed method validated experimentally using real injection molding machine results demonstrate efficiency proposed method
background previously reported cell deficits pro inflammatory gene activation circulating monocytes two cohorts bipolar disorder patients cohort postpartum psychosis patients bipolar offspring pro inflammatory gene activation occurred two clusters mutually correlating genes cluster inflammation related cytokines factors cluster motility chemotaxis metabolic factors aim verify cellular immune abnormalities yet another cohort bipolar stress study biss cohort relative old years median patients relate immune abnormalities hair cortisol levels measured cohort representing long term systemic cortisol levels presence metabolic syndrome mets prevalent biss patients methods monocyte immune gene activation quantitative polymerase chain reaction cell deficits fluorescence activated cell sorting analysis determined well controlled largely euthymic biss patients monocyte genes included cluster genes genes glucocorticoid receptor alpha beta gene hepatocyte growth factor hgf marker monocyte derived circulating angiogenic cells cacs cacs serve vessel repair abnormal numbers found patients mets vascular damage results compared healthy controls pro inflammatory cluster genes downregulated alpha hgf gene upregulated monocytes biss patients cell deficits shown reduced numbers lymphocytes particular cells within reduced cell population shift taken place helper populations helper helper increased regulatory cells decreased correlations hair cortisol mets monocyte gene activation cell deficits found conclusion cell deficits likely trait phenomenon since also found cohorts patients bipolar offspring monocytes cohort showed anti inflammatory set point suggesting pro anti inflammation state characteristics monocyte gene profile indicated increased cac activity question arises whether due putative vessel damage relatively old patients high prevalence mets
work compares fundamental thermodynamic underpinnings working fluid properties heat release profile various combustion strategies engine measurements approach employs model separately tracks impacts efficiency due differences rate heat addition volume change mass addition molecular weight change given combination working fluid heat release profile engine geometry comparative analysis measured modeled efficiencies illustrates fundamental sources efficiency reductions opportunities inherent various combustion regimes engine operating regimes chosen analysis include stoichiometric spark ignited combustion lean compression ignited combustion including homogeneous charge compression ignition spark assisted homogeneous charge compression ignition conventional diesel combustion within combustion regime effects engine load combustion duration combustion phasing compression ratio charge dilution explored model findings illustrate even absence losses heat transfer incomplete combustion maximum possible thermal efficiency inherent operating strategy varies significant degree additionally experimentally measured losses observed unique within given operating strategy findings highlight fact create roadmap future directions internal combustion engine technologies important compare absolute real world efficiency given combustion strategy also examine measured efficiency context thermodynamically possible working fluid boundary conditions prescribed strategy
biotechnological process fatty amides dodecyloctadeca dienamide dodecy hydroxybenzamide respectively derived linoleic acid salicylic acid synthesized aminolysis reactions catalyzed candida antarctica lipase amphiphilic compounds receive great attention cosmetic industry due range beneficial properties skin aminolysis reactions performed esters ethyl linoleate ethyl salicylate acyl group donors fatty compound dodecylamine nucleophilic substrate aminolysis reactions carried solvent free process beneficial environmental economical perspective degrees reduced pressure mbar parameters enzyme amount substrates molar ratios investigated products monitored hplc analysis conversion rates measured disappearance ethyl linoleate ethyl salicylate best conversion rates obtained adding enzyme amount mol acyl donor group substrate equimolar substrates ratio products characterization performed high resolution mass spectrometry infrared spectroscopy nuclear magnetic ressonance work reveals enzymatic synthesis provides attractive way cosmetic industrial production fatty amides may represent key ingredients maintain restore healthy skin elsevier rights reserved
objective determine rdw mpv levels ankylosing spondylitis investigate relations disease activity materials methods patients male female age sex matched controls male female enrolled demographic data disease activity scores complete blood count cbc erythrocyte sedimentation rate esr reactive protein crp levels recorded results mean ages patients controls years respectively rdw inactive basdi patients respectively rdw positively correlated basdai esr crp plt levels mpv correlated basdai negatively correlated esr cpr plt levels conclusions rdw mpv significantly higher patients controls rdw correlated basdai aprs mpv correlated aprs
automatic image annotation active topic research field computer vision pattern recognition decades paper present new method automatic image annotation based gaussian mixture model gmm considering cross modal correlations specific first employ gmm fitted rival penalized expectation maximization rpem algorithm estimate posterior probabilities annotation keyword next label similarity graph constructed weighted linear combination label similarity visual similarity seamlessly integrating information image low level visual features high level semantic concepts together effectively avoid phenomenon different images candidate annotations would obtain refinement results followed rank two relaxation heuristics built label similarity graph applied mine correlation candidate annotations capture refining annotation results plays crucial role semantic based image retrieval main contributions work summarized follows exploiting gmm trained rpem algorithm capture initial semantic annotations images label similarity graph constructed weighted linear combination label similarity visual similarity images associated corresponding labels refining candidate set annotations generated gmm solving max bisection based rank two relaxation algorithm weighted label graph compared current competitive model sgmm achieve significant improvements precision recall corelk mirflickrk respectively elsevier inc rights reserved
water clocks century islamic scientist ismail jazari may regarded among outstanding engineering masterpieces history science technology persia works testify remarkable ability design methodology different aspects mechanical engineering design manufacture robotics fluid mechanics strength materials statics study experimental archaeology two water clocks namely dragon clock peacock clock considered purposes making working reconstructions historical background design details technical comparative analysis inventions presented replicas constructed accordance indications provided jazari compendium theory practice mechanical arts tests shown clocks operated exactly described book acceptable degree precision
paper based practical engineering design case northeast china combined actual engineering situation local climatic conditions technical method integrated design solar water heater building investigated provides reference guidance application solar energy residential building design conducive promoting wide use renewable energy green residential building
controlled delivery protein would find diverse therapeutic applications formulation protein nanoparticles polyelectrolyte complexation protein natural polymer chitosan popular approach however current method batch mode mixing faces significant challenges scaling maintaining size control high uniformity high encapsulation efficiency report new method termed flash nanocomplexation fnc fabricate insulin nanoparticles infusing aqueous solutions tripolyphosphate tpp insulin rapid mixing condition multi inlet vortex mixer comparison bulk mixing method optimized fnc process produces tpp insulin nanoparticles smaller size narrower size distribution higher encapsulation efficiency dependent nanoparticle dissolution insulin release tpp insulin nanoparticles lyophilized reconstituted without loss activity produced throughput flow rate min used evaluated type diabetes rat model smaller nanoparticles control blood glucose level oral administration effectively larger particles efficient reproducible continuous fnc technique amenable scale order address critical barrier manufacturing translation protein nanoparticles elsevier ltd rights reserved
developed fully automated procedure analyzing data led pulses multilevel bead sets evaluate backgrounds photoelectron scales cytometer fluorescence channels method improves previous formulations fitting full quadratic model appropriate weighting providing standard errors peak residuals well fitted parameters describe details methods procedures involved present set illustrations test cases demonstrate consistency reliability results automated analysis fitting procedure generally quite successful providing good estimates spe statistical photoelectron scales backgrounds fluorescence channels instruments good linearity precision results obtained led data almost always better multilevel bead data bead procedure easy carry provides results good enough purposes including standard errors fitted parameters important understanding uncertainty values interest weighted residuals give information well data fits model particularly high residuals indicate bad data points known photoelectron scales measurement channel backgrounds make possible estimate precision measurements different signal levels effects compensated spectral overlap measurement quality combining information measurements standard samples carrying dyes biological interest make accurate comparisons dye sensitivity among different instruments method freely available bioconductor package flowqb international society advancement cytometry
invasive fungal infection ifi major life threatening problem encountered patients hematological malignancies receiving intensive chemotherapy empirical antifungal agents therefore important despite availability antifungal agents situations optimal agents administration methods remain unclear conducted prospective phase study empirical day liposomal amphotericin amb patients receiving intensive chemotherapy hematological malignancies enrolled patients high risk recurrent prolonged febrile neutropenia despite received broad spectrum antibacterial therapy least hours fifty three patients achieved primary endpoint successful treatment thus exceeding predefined threshold success rate patients developed ifi treatment completion rate two cases ceased treatment adverse events frequent events reversible electrolyte abnormalities consider low dose amb provide comparable efficacy improved safety cost effectiveness compared empirical antifungal therapies additional large scale randomized studies needed determine clinical usefulness amb relative empirical antifungal therapies
cross hybrid concept demonstrated experimentally insulated gate bipolar transistor igbts sic mosfets parallel used calibrate technology computer aided design simulations hybrid offers lower switching losses compared full igbts reduced oscillations compared full sic mosfets current sharing mechanism igbt mosfet hybrid elucidated showing typical switching conditions igbt dissipate hybrid turn losses compared sic mosfet since current density igbt hybrid twice full igbt solution exhibits higher dynamic avalanche features results stress device package level thereby compromising robustness reliability order overcome issues show increasing turn gate resistance improves current sharing hybrid delaying turn mosfet thereby suppressing dynamic avalanche igbt
patients severe stage dementia present several psycho behavioral disorders caused altered perception environment feeling isolation bedridden advanced stage alzheimer disease causes cognitive dysfunctions physical disorders including coordination movement problems consequently freedoms movement limited well quality communication study new care support using activities ground proposed compensate massive cognitive psychological losses enhance communication skills results study show ground activities seem promising way reduce psycho behavioral disorders recreate communication link patients presenting severe stage dementia
article describes evaluates initial steps gender sensitive youth friendly group intervention model designed teenage girls young women experience stress related psychosomatic problems fifty four young women years age participated gender sensitive physiotherapy stress management course youth health center inclusion criteria self defined stress related problems wish participate group intervention measurements aspects body perception self image multiple somatic problems mental health symptom areas assessed intervention body perception questionnaire modum schioler social analysis social behavior adult self report scale significant positive changes found aspects body perception self image mental health somatic symptoms changes significant lower internalization anxiety depression symptoms symptoms headaches sleeping problems decreased participants satisfied bodies able listen body signals among cognitive issues significant change occurred thought problems attention problems intervention model needs evaluation controlled trials promising developed physiotherapy settings subgroups young people
current situation intelligent energy management essential necessary change way delivered also users use small changes life daily turning lights air conditioning people use result substantial energy savings document provide information support system energy conservation using sensors actuators agents wireless network system embedded interconnected agents sensors monitoring room actuators gradually manipulate elements like windows blinds led lamps air conditioning besides application optimization techniques fuzzy logic energy required give comfort comes two main sources possible artificial company supply electricity natural natural air flows solar lighting etc main goal bio inspired optimization algorithms fuzzy logic control provides adequate lighting temperature settings according activity takes place room
intergroup contact positive interactions people different social groups widely researched strongly supported prejudice reducing mechanism shown reduce prejudice wide variety outgroups however known previous research investigated whether intergroup contact also reduce sexism women sexism array negative outcomes one detrimental violent ones rape justified downplayed rape myth acceptance hypothesised frequent higher quality contact counter stereotypical women would predict lower levels sexism thus less rape myth acceptance men less sexualised projected responses rape women two studies using online surveys community samples supported hypotheses study male participants experienced positive contact counter stereotypical women reported less intention rape similarly study female participants experienced positive contact counter stereotypical women reported less projected sexual arousal thought raped thus present research first known show contact could potential tool combat sexism rape myth acceptance intentions rape men sexualisation rape women
purpose review microbiome term describes microbial ecosystem cohabits organism humans microbiome implicated long list immune mediated diseases include rheumatoid arthritis ankylosing spondylitis even gout mechanisms account effect multiple clinical implications observations microbiome disease broad recent findings growing number microbiota constituents prevotella copri porphyromonas gingivalis collinsella correlated causally related rheumatic disease microbiome marked effect immune system understanding immune pathways modulated microbiota induction helper cells secretory immunoglobulin iga responses segmented filamentous bacteria continues expand addition gut microbiome bacterial communities sites mouth lung skin also associated pathogenesis rheumatic diseases summary strategies alter microbiome alter immune activation microbiome might play role future therapy rheumatic diseases
since devastating tornado season renewed interest understanding tornado wind loads developing methodologies reduce risk tornado damage study focuses assessment system level performance five different residential light frame wood building archetypes subjected tornado winds system level performance considered three critical components along vertical load path within building namely roof sheathing roof wall connection wall foundation anchorage although significant work components independently combined uplift lateral forces received less attention therefore laboratory testing program wood shear walls reported herein performed determine wall failure mechanisms capacities subjected combined shear uplift forces building archetype designed varying locations across united states based current residential building code observed practice fragilities developed based assumption failure component along vertical load path results failure system forces connection along vertical load path arise tornado wind load connection failures statistically independent monte carlo simulation applied perform system reliability analysis american society civil engineers
biomass pyrolysis one important means realize effective treatment efficient utilization biomass wastes materials therefore great practical significance research process mechanism biomass pyrolysis wood renewable material rich source kind pyrolysis raw material among lots biomass know difference composition aspects pyrolysis characteristics different tree species obvious differences however even kind wood heartwood sapwood lumber show different pyrolysis characteristics products process pyrolysis due significant differences aspects microstructure chemical composition amount component studied feild paper experiment sabina chinensis kind common landscaping taken test material whose heartwood sapwood clearly distinct order research pyrolysis differences heartwood sapwood ftir method used obtain thermogravimetric curves volatile spectrograms process results elucidated content cellulose hemicellulose lignin extracts remarkably effect heartwood sapwood account higher content hemicellulose lignin heartwood sabina chinensis showed higher weight loss ratio sapwood early late stages higher content extracts increased weight loss ratio heartwood medium stage reduced differences heartwood sapwood contrary sapwood cellulose obvious weight loss similar omicron higher weight loss ratio dtg curve addition infrared spectrum indicated heartwood sapwood produced almost volatiles differences amount pyrolysis came maximum weight loss velocity volatiles produced increased significantly moreover sapwood produced organic compounds heartwood produced water
individuals history epilepsy higher risk bone fractures compared general population although clinical studies support association low bone mineral density bmd anti seizure medications little known whether history seizures linked altered bone health therefore study tested hypothesis bone mass morphology bone mineralization altered seizures genetically epileptic animals animals subjected episode status epilepticus study used pten conditional knockout mice well studied genetic model epilepsy used microct analysis measure bmd morphology mineralization pten wildtype pten knockout mice weeks well adult mice measured bmd bone morphology mineralization adult pten mice received status epilepticus kainic acid intraperitoneal measured locomotion pten pten mice weeks found pten mice exhibited low bmd tibial metaphysis midshaft compared non epileptic mice morphologically pten mice exhibited decreased trabecular volume fraction endocortical expansion metaphyeal diaphyseal compartments midshaft pten mice exhibited reduced tissue mineral density indicating impaired mineralization addition morphological deficits pten mice exhibited hyperactivity open field testing suggesting low bone mass pten mice attributable hypoactivity differences bmd observed following kainate induced seizures model seizure susceptibility findings suggest deletion pten brain results impaired bone mass mineralization may contribute weaker bones thereby higher fracture risk elsevier inc rights reserved
european guidelines cardiovascular prevention recommend combining population high risk strategies lifestyle changes cornerstone prevention propose score function quantify cardiovascular risk guidelines highlight disease specific interventions conditions women young people ethnic minorities screening subclinical atherosclerosis noninvasive imaging techniques recommended guidelines distinguish four risk levels high high moderate low therapeutic objectives lipid control according risk diabetes mellitus confers high risk except subjects type diabetes less years evolution without risk factors complications type diabetes short evolution without complications decision start pharmacological treatment arterial hypertension depend blood pressure level cardiovascular risk taking account lesion target organs guidelines recommend antiplatelet drugs primary prevention increased bleeding risk low adherence medication requires simplified therapeutic regimes identify combat causes guidelines highlight responsibility health professionals take active role advocating evidence based interventions population level propose effective interventions individual population level promote healthy diet practice physical activity cessation smoking protection alcohol abuse published elsevier espana behalf sespas
nano micro scales resistance particle rolling critical factor many applications biological phenomena affects particle adhesion motion flow well particle manipulation picking placing microparticles present work non contact non invasive experimental method detailed applied determine pre rolling critical leaning angle cla single microparticles transient rayleigh surface acoustic waves saw utilized excitation mechanism interferometry image processing detection monitoring analysis techniques capturing micro nano scale dynamics microparticles cla values set psl polystyrene latex microparticles diameter soda lime glass substrate reported cia studied particles determined degrees also observed saw field burst cycle microparticles could change drifting rolling sliding directions speeds accelerations trajectory particle often found non linear nonlinear behavior attributed inhomogeneity surface properties particles substrate well possible electric charge density chemistry variations potential contamination surfaces moreover effect electric charge developed due triboelectric effect particle drifting motion investigated found percentage drifting particles function amplitude excitation field also function possible electrostatic charges developed particles due drifting motion substrate addition potential uses particle manipulation removal adhesion characterization reported results could utilized numerical simulations microparticle motion deposition elsevier rights reserved
using dot probe discrimination task subjects design examined time course attentional biases facilitated attention delayed disengagement avoidance toward thin versus fat bodies explored influence body dissatisfaction attention allocation among sample women general population three stimulus presentation times used also used neutral body shape related stimuli neutral stimuli related concept interest overcome limitations previous studies results highlighted delayed disengagement thin negatively assessed bodies among women high mechanism leads attentional focalization bodies difficult achieve might considered dysfunctional may maintain reinforce results well results fat bodies conclusive elsevier ltd rights reserved
context networks grow larger larger nodes become likely fail indeed may subject crashes attacks memory corruptions encompass possible types failure consider general model failure byzantine model failing node may exhibit arbitrary potentially malicious behavior consider asynchronous grid shaped network node probability byzantine metric communication probability probability two nodes communicate reliably number byzantine resilient broadcast protocols exist share weakness size grid increases communication probability approaches zero paper present first protocol overcomes difficulty ensures communication probability grid may large want sufficiently small lambda typically lambda originality approach lies fractal definition protocol believe could used solve several similar problems related scalability also extend scheme dimensional grid obtain communication probability
hydraulic wind power transfer systems exhibit highly nonlinear dynamic influenced system actuator hysteresis disturbances wind speed load torque paper presents system identification approach approximate nonlinear dynamic piecewise affine pwa models obtained utilizing averaged nonlinear models hysteresis confined space state space representation pwa models obtained allocated operating point clusters experimental results demonstrate close agreement simulated experimental results simulation show match
aim research examine pathway intergroup forgiveness postconflict contexts framework improved intergroup relations emphasis identifying context specific variables two studies investigated relationship intergroup contact ingroup contact norms postconflict forgiveness context anglo german post wwii relations study provided evidence intergroup anxiety common ingroup identity significantly predicted positive intergroup contact ingroup norms predicted forgiveness german outgroup wartime actions accordingly focusing greek turkish cypriot relations cyprus results study showed positive contact greek cypriots ingroup contact norms related decreased intergroup anxiety dehumanization turn associated increased forgiveness results discussed context intergroup relations postconflict resolution
particularly automotive industry combination dissimilar materials presents manufacturing engineering major challenges notably adapted use plastic metal opens potential weight savings directly firmly bonding two materials together fails however account chemical physical dissimilarity plastic metal since joining plastics metals nowadays based adhesive bonding joint weak underlies ageing processes promising approach overcome problems laser based two step process first process step laser radiation applied generate microstructures surface metallic joining partner subsequent laser joining process plastic molten interlocked microstructures curing mechanical strength joint depends strongly load direction influenced geometry arrangement microstructures influencing factors investigated three different load directions tensile shear tensile peel experiments structural mechanics simulations
purpose youth sport potential one healthiest beneficial activities children partake participation combination adult led peer led sport structures appears lead favorable outcomes enhanced physical fitness well social emotional development purpose present study examine subjective objective experiences recreational male soccer players aged years old years across adult led peer led sport structures method direct video observation experience rating scales utilized effort shed light impact adult led peer led sport structures athletes results adult led structures youth experienced high levels effort concentration spending time physically mentally engaged meanwhile youth experienced high rates prosocial behaviors sport related communication general communication peer led structures conclusions results present study indicate rather one approach superior adult peer led sport structures potential yield unique benefits toward children positive experiences sport
within past decade mobile computing morphed principal form human communication business social interaction unfortunately energy demands newer ambient intelligence collaborative technologies mobile devices greatly overwhelmed modern energy storage abilities paper proposes several novel techniques exploit spatiotemporal device context predict device wireless data location interface configurations optimize energy consumption mobile devices techniques include variants linear discriminant analysis linear logistic regression non linear logistic regression neural networks nearest neighbor support vector machines explored compared synthetic user traces real world usage studies experimental results show successful prediction possible neural networks nearest neighbor algorithms improving upon prediction strategies prior work approximately average improvement energy savings achieved compared state art prior work energy efficient location sensing
rapid developments made synthetic biology within past two decades particularly combination chemistry computer science disciplines genetic components internal features main focus research synthetic biologists logic gates applied various disciplines yet used plasmid design genocad computer aided design software programme synthetic biology used design complex structures thus study authors analysed large commonly used data set containing feature sequences eventually obtained comprehensive information complete data set without redundancy analysing internal feature sequences authors input representative data genocad platform along design rules grammar constructing high quality practical parts additionally orderly logic gate building biological parts designed study may useful professionals non professionals may applications design new biological computer finally authors compared constructed plasmid successful examples blast plasmapper software demonstrate rationality orderly logic gate
although heterogeneity therapeutic response tnf blockers seems mainly due genetic factors several studies showed range factors may influence aim study investigate impact patients demographic clinical characteristics primary response anti tnf therapy psoriatic patients retrospectively examined relationship various clinical demographic features response treatment etanercept adalimumab infliximab evaluated pasi average pasi improvement weeks respectively analyzed data obtained patients better response treatment significantly associated male gender coexistence psoriatic arthritis pasi baseline present study supports clinical factors may potential predictors response anti tnf agents psoriatic patients
recent years witnessed tremendous progress molecular characterization philadelphia negative myeloproliferative neoplasms mpn beside better understanding pathophysiology abnormalities often constitute useful diagnostic markers diseases exclusion reactive states used strongest argument however conventional molecular cytogenetics keep major interest mpn either second line exploration cases molecular marker available differential diagnosis proof clonality first line cases hyperleukocytosis differential diagnosis cml evidence druggable targets abl ret pdgfr prognosis marker article review interest cytogenetic techniques myeloproliferative neoplasms
cloud computing distributed computing paradigm provides opportunities solve large scale problems resource provisioning pay per use main advantage moving towards cloud even though many workflow scheduling algorithms available applied cloud since fail incorporate elasticity heterogeneity cloud paper cloud workflow scheduling problem modeled considering make span deadline two objectives hybrid algorithm particle swarm optimization pso memetic algorithm called particle swarm memetic algorithm psma proposed heuristic tested several well known scientific workflows results obtained shows psma performs better state art algorithms
coast parallel submerged breakwaters made geotextile sand containers gscs increasingly incorporated coastal management solutions cost effective environmentally friendly characteristics reduce wave action lee side forcing wave breaking stability function relative crest width crest height damage present work involves physical model study sloped trapezoidal submerged reefs constructed gscs different alignments like perpendicular parallel flemish height varying crest widths tested stability wave heights wave periods water depth authors published elsevier ltd
goals study report embryonic fetal ultrasound changes compare blood flow uteroplacental umbilical arteries normal abnormal conceptus accordingly day mating artificial insemination fetuses pregnancies evaluated weekly according ultrasound findings gestational age determined conceptuses divided normal abnormal embryonic fetal abnormalities two dimensional ultrasound assessment consists measuring evaluating echogenicity conceptus extra fetal structures doppler velocimetry measured resistivity index pulsatility index uteroplacental umbilical arteries two dimensional doppler measurements expressed mean standard deviation differences normal abnormal groups subject mann whitney test fetuses showed embryonic abnormalities resorption presented fetal abnormalities congenital abnormalities fetal underdevelopment fetal death observed reduced diameter abnormalities contour gestational vesicle lack viability increased placental thickness increased fluid echogenicity increases uteroplacental arteries conceptuses embryonic resorption weeks fetuses abnormalities showed changes flow uteroplacental umbilical arteries prior visualization two dimensional alterations different vascular behavior according classification change results show ultrasound efficient detection embryonic fetal abnormalities combined doppler ultrasound allows early detection gestational changes well hemodynamic changes conceptuses abnormalities may influence development elsevier rights reserved
discovery two distinct subsets helper cells ifn gamma producing cells producing cells three decades ago enabled understand immunopathology cell mediated allergic inflammatory diseases humans observation cell mediated experimental autoimmune diseases induced mice lacking cell responses prompted many immunologists hypothesize might additional subsets helper cell population mediate autoimmunity absence cells consequently multiple independent research groups identified expressing ror gamma cell population distinct subset helper cells promotes autoimmune tissue inflammation subsequent studies revealed innate immune cells including gamma delta cells nkt cells innate lymphoid cells also produce type cytokines contribute tissue inflammation review discuss current understanding biology therapeutic potential targeting treatment immune disorders humans
hydrokinetic smart grid ksg concept powered modules hydrokinetic microturbines arranged rows proposed work complete description module mechanical design hydropower characteristics power electronics control strategies included complete dynamic simulation example ksg performed considers microturbine modules power loads energy storage modules grid tie inverter interface mains using single connection additionally control power stages hydrokinetic microturbine validated satisfactory technical results obtained addition acceptable results investment analysis encourage future implementations ksgs
stochastic convergence analysis parameter vector estimation obtained recursive successive relaxation rsor algorithm performed mean sense mean square sense also excess mean square error misadjustment analysis rsor algorithm presented results verified ensemble averaged computer simulations furthermore performance rsor algorithm examined using system identification example compared widely used adaptive algorithms computer simulations show rsor algorithm better convergence rate widely used gradient based algorithms gives comparable results obtained recursive least squares rls algorithm
predominant technical challenge upstream oil gas industry always fundamental uncertainty subsurface produces hydrocarbon fluids subsurface detected remotely example seismic waves penetrated studied extremely limited vicinity wells inevitably great deal uncertainty remains computational sciences key avenue reduce manage uncertainty review discuss relatively non technical level current state three applications computational sciences industry first seismic imaging currently revolutionized emergence full wavefield inversion enabled algorithmic advances petascale computing second reservoir simulation also advanced use modern highly parallel computing architectures finally comment role data analytics upstream industry article part themed issue energy subsurface
novel magnetic force driven noncontact electromagnetic triboelectric hybrid nanogenerator scavenging biomechanical energy sustainably power portable electrics presented based effective conjunction electromagnetic induction triboelectrification hybrid nanogenerator small dimension consists electromagnetic generator emg peak output power load resistance omega triboelectric nanogenerator teng peak output power load resistance omega teng electrospun feo nanoparticles embedded pvdf fibers membrane employed triboelectric layer magnet utilized trigger non contactly drive contact separation mode teng due magnetic responsiveness triboelectric materials emg drived coupling magnet copper coils simultaneously hybrid nanogenerator exhibits good stability output performance charging performance utilized charge energy storage devices sustainably power portable electronics work demonstrates novel prototype hybrid nanogenerators toward harvesting human biomechanical energy potential applications building self powered systems
background self management key recommendation people rheumatoid arthritis educational materials may support self management increasingly patients becoming involved development materials titrate trial compares effectiveness intensive management standard care patients moderate across england part intensive management intervention participants given handbook aim objectives aim study develop handbook support intensive management objectives involve patients identification relevant information inclusion titrate handbook ensure content handbook acceptable accessible design held audio taped workshop patients transcript workshop analysed using thematic content analysis results five main themes identified follows rheumatoid arthritis treatment perceptions rheumatoid arthritis importance individualized goals benefits self management patient handbook feedback workshop incorporated handbook patients anonymous testimonies added conclusion study demonstrates patient contribution development educational material support intensive management feasible valuable qualitative evaluation use impact handbook patients practitioners planned completion titrate trial
echocardiography pivotal evaluating aortic stenosis past several decades recent experience shown wide spectrum clinical presentation better understanding underlying hemodynamic principles resulted emergence new subtypes new treatment modalities also introduced requiring precise evaluation aortic valve pathology implementation therapies review discuss new concepts indices use echocardiography patients specifically address hemodynamic characteristics clinical presentation management normal flow high gradient paradoxical low flow low gradient classical low flow low gradient aortic stenoses
medical imaging become integral part modern medical technology increasingly image information provided multimode imaging technology complement fusing computed tomography magnetic resonance imaging mri images combine unique information diagnose brain diseases radiation therapy medical imaging process easy produce noise impact doctors diagnosis medical image noising important significance addition image edge extraction helpful clinical diagnosis paper constructs tnemristive pulse coupled neural network pcnn medical image processing memristance gale memristor decays exponentially time used adjust threshold pulse coupled neural network pcnn online integrating memorability memristor pcnn makes network biological function introduction nanoscale memristor also significantly reduce scale pcnn may promote development neural network hardware implementation numerical simulation verifies superiority using network medical image fusion image noising image edge extraction
background limited successes gene finding major depressive disorder mdd may partly due phenotypic heterogeneity tested whether genetic load mdd bipolar disorder schizophrenia scz increased phenotypically homogenous mdd patients identified specific clinical characteristics methods patients dsm mdd diagnosis control subjects two large cohort studies netherlands study depression anxiety netherlands twin register genomic profile risk scores gprss mdd bipolar disorder scz based meta analysis results psychiatric genomics consortium regression analyses adjusted year birth sex three principal components examined association gprss characteristics gprss mdd subgroups stratified according relevant characteristics proportion liability variance explained gprss mdd subgroup estimated results gprs mdd explained mdd variance mdd endorsing nine dsm symptoms gprs bipolar disorder explained mdd variance mdd age onset years gprs scz explained mdd variance mdd higher symptom severity mdd endorsing nine dsm symptoms independent sample replicated pattern stronger associations cases dsm symptoms compared overall mdd gprs scz conclusions mdd patients early age onset higher symptom severity increased genetic risk three major psychiatric disorders suggesting useful create phenotypically homogenous groups searching genes associated mdd
previous studies shown socio demographic factors childhood socioeconomic status cses childhood traumatic experiences ctes social support behavioral factors associated health well adulthood however relative importance factors mental health health well studied moreover mechanisms ctes affect mental health health well adulthood clear using data representative sample adult population tromso norway study examines relative contribution structural conditions gender age cses psychological abuse physical abuse substance abuse distress social support behavioral factors adulthood relative contribution socio demographic factors cses ctes social support behavioral factors three multi item instruments mental health scl health subjective well swls adulthood iii impact ctes mental health health well adulthood mediating role adult social support behavioral factors associations instrumental support explained variation mental health gender explained variation health emotional support explained variation wellbeing psychological abuse relatively important mental health health well compared physical abuse substance abuse distress subjective assessment childhood financial conditions relatively important mental health health well compared mother father education ctes relatively important mental health cses relatively important health wellbeing respondents exposed three types ctes two fold increased risk mentally unhealthy rrtotal effect increased risk unhealthy total effect increased risk low level well adulthood rrtotal effect social support behavioral factors mediate effects study advances theoretical understanding ctes influence adult mental health health well
paper presents new curvature compensated cmos bandgap reference topology high power supply reject ratio psrr dual differential input amplifier ddia used generate complementary absolute temperature voltage voltage ddia used fine tune curvature compensation experimental characterization bandgap reference circuit implemented cmos process yielded bandgap reference voltage temperature coefficient ppm degrees across temperature range degrees psrr also realized high output load current driving ability without use external buffer amplifier
pulmonary valve replacement pvr common adult congenital cardiac operation performed valve degeneration leading prosthetic stenosis regurgitation long term risk population may associated paravalvular leak pvl complications involving proximal pulmonary artery including dissection less clearly defined herein report case year old patient history multiple pulmonary valve interventions secondary congenital pulmonic stenosis developed dehiscence bioprosthetic pvr associated significant paravalvular leak pvl complicated focal dissection proximal pulmonary artery
effort meet needs adults autism spectrum disorder asd hospitalized team experts providers massachusetts general hospital mgh mgh children well parents individuals asd sparked became multidisciplinary collaborative mgh autism care collaborative improve adult care inpatients asd collaborative created three goals mind educate internal medicine adult inpatient providers staff unique needs adults asd hospitalized create asd specific resources internal medicine adult inpatient providers optimize patient care admission discharge among adults asd admitted internal medicine services
present study investigated true false memory manifestations adaptive maladaptive perfectionism using drm deese roediger mcdermott word lists paradigm ninety seven college students administered drm paradigm completed almost perfect scale revised slaney rice mobley trippi ashby signal detection analyses revealed perfectionism strivings associated accurate memory whereas perfectionistic concerns associated higher levels false memories higher confidence ratings accuracy memories moreover individuals high perfectionistic concerns manifested lower memory discriminative ability suggesting poor working memory capacity findings corroborate previous studies suggesting working memory involvement false memories call investigation cognitive emotional processes underlying false memories elsevier ltd rights reserved
resilience capacity historic buildings adapt plays vital role mitigating climate change adaptive reuse adaptive reuse buildings practical substitute demolition substantial economic environmental social benefits however tensions exist retention heritage buildings conformance regulatory requirements energy efficiency reduce greenhouse gas emissions disability access etc raises questions whether regulatory systems embrace green building technologies heritage conservation principles paper examines challenges barriers successful adaptive reuse projects australia using qualitative approach involves multiple case studies depth interviews industry experts coupled field observation building plan appraisals findings show compliance codes regulations current design requirements major challenges encountered undertaking adaptive reuse projects underlying parameters identified challenges serve initiative formulating prospective regulations address changing building use encourage integration modern technologies inhibit unnecessary building demolition future global climate protection
addressing climate change impacts agriculture special challenge number factors influence extent farmers particular location adopt csa technologies study applied participatory assessment method assess farmers preferences willingness pay selected csa practices technologies diverse rainfall zones study found farmers preferences csa technologies marked commonalities well differences according socio economic characteristics rainfall zones preferred technologies local farmers crop insurance weather based crop agro advisories rainwater harvesting site specific integrated nutrient management contingent crop planning laser land levelling results also indicate furriers preferences willingness pay influenced technologies cost implementation study shows potential using participatory csa prioritization approach provide information climate change adaptation planning local level authors published elsevier ltd
aim study assess long term functional outcome patients bipolar disorder baseline follow period least months three measures functioning administered psychosocial functioning gaf employment status full time part time unemployment disability self reported measure functional recovery baseline patients five previous affective episodes exhibited poorer outcomes measures functioning patients less five previous episodes however along mean follow period months measures functioning tended remain stable improved slightly results highlight limitation studies comparing measures functioning patients many episodes evaluate functional outcome likewise preliminary results support hypothesis functional outcome deteriorates course
microscopic traffic simulators important tools studying transportation systems describe evolution traffic highest level detail major challenge microscopic simulators slow simulation speed due complexity traffic models developed scalable microscopic adaptive road traffic simulator smarts distributed microscopic traffic simulator utilize multiple independent processes parallel smarts perform fast large scale simulations example simulating million vehicles area size melbourne system runs times faster real time computing nodes simulation timestep smarts supports various driver models traffic rules car following model lane changing model driver dependent simulate multiple vehicle types including bus tram simulator equipped wide range features help customize calibrate monitor simulations simulations accurate confirm real traffic behaviours example achieves accuracy predicting traffic freeway minutes future simulator used predictive traffic advisories well traffic management decisions simulations complete well ahead real time smarts easily deployed different operating systems developed standard java libraries
harmonic impedance important parameter electrical power system analyses parameter applied important application island resonance detection work presents impedance estimation technique implemented real time method uses small current disturbance injection harmonic frequency uses sliding window recursive discrete fourier transform swrdft calculate magnitude phase component current voltage small current disturbance modified morlet wavelet waveform sequential small waves one centered harmonic frequency injected network order quantify impact sequential waves injection power quality new factor defined named root mean square ratio rmsr estimation technique implemented real time using dspace computer electrical network whose harmonic impedance point common coupling required simulated real time digital simulator rtds
objective work improve kiwifruit drying respect quality drying kiwifruit slices studied hot air drying hybrid hot air infrared drying hid degrees air velocity thickness using full factorial design shrinkage color changes kiwifruit slices monitored real time computer vision system cvs drying treatments ranked based desirability function using combination minimal color change minimal shrinkage drying time decision criteria proper conditions kiwifruit drying determined average linkage method clustering temperature degrees thickness air velocity hid finally hybrid approach hid first stage second stage drying proposed reasonable compromise drying time product quality
combine complementary strengths human vision computer vision target image retrieval proposed brain computer interface framework bayesian retrieval bhcr couples bayesian method retrieve target images rapid serial visual presentation rsvp sequences construct well suited electroencephalogram eeg decoding module bhcr conducted comparative inspection selection classification algorithms adopted linear discriminant analysis random forests feature extraction method classification algorithm respectively also introduced system based convolutional neural network cnn component bhcr bayesian brain computer interaction bbc module carefully designed presented image bayesian model takes insight prior information insights sample information built present retrieval results unlike existing coupled works usually require extra manual labor bhcr directly enhanced retrieval performance help insights auxiliary work natural extension bhcr proposed probability propagation scheme incorporates eeg decoding insights improve system one shot image database retrieval scheme demonstrated effectiveness bhcr extensive experiments simulations entire framework sub components results showed following performance bhcr significantly better eeg mechanism receiver operating characteristic roc classification aspects robustness bhcr ensured process flow steady performances sub components elsevier rights reserved
united states hiv evolved acute disease chronic illness making health related quality life pre eminent goal many persons living hiv plwh number hiv specific quality life instruments developed little attention paid validation standardized nondisease specific quality life instruments tailored plwh goal research validate patient reported outcomes measurement information system promis questionnaire measures health related quality life plwh sample plwh completed online anonymous survey assessing symptom experience health related quality life subsample participants completed another questionnaire days later subscales promis showed high internal consistency reliability range promis detected differences health related quality life persons reported aids diagnosis compared report aids diagnosis promis demonstrated reliability validity reproducibility use measuring health related quality life plwh
paper addresses electricity transmission planning new industry institutional structure mexican electricity market engaged deep reform process decades state owned vertically integrated non competitive closed industry new structure characterized nodal pricing system independent system operator iso analyze welfare optimal network expansion two modeling strategies first model propose use incentive price cap mechanism promote expansion mexican networks second model study centrally planned grid expansion mexico iso within power flow model carry comparisons models provide hints evaluate actual transmission planning process proposed mexican authorities prodesen obtain prodesen plan appears convergent welfare optimal planning process
background extent high sensitivity reactive protein hscrp associated known cardiovascular risk factors children type diabetes fully explored methods forty two children age years without hypertension retinopathy hypothyroidism albuminuria endocrine diseases controls studied patients studied prepubertal early pubertal tanner pubertal tanner iii post pubertal tanner results children showed higher hscrp controls disease duration years within group children conversely non high density lipoprotein hdl cholesterol different subgroup analysis moreover non hdl cholesterol correlated age disease duration fasting glucose conclusions non hdl cholesterol might useful hscrp evaluate future cardiovascular risk children
rationale negative affective state anhedonia emerges abstinence abused drugs may linked motivational processes drug craving relapse although anhedonia diminishes time drug abstinence yet rather explicit whether anhedonia exists following protracted withdrawal objectives behavioral responses natural rewards examined weeks withdrawal morphine male rats pretreated either binge like morphine paradigm daily saline injection days consummatory motivational behaviors three natural rewards sucrose solutions social stimulus male rat sexual stimulus estrous female rat examined varied testing conditions results morphine withdrawn rats significantly increased intake sucrose solution consumption test operant responding sucrose solution progressive ratio schedule reinforcement obtaining reinforcer associated foot shock punishment schedule morphinewithdrawn rats showed higher performance sucrose solution meanwhile morphine withdrawn rats displayed higher motivation sexual stimulus freeapproach test approaching behaviors towards sexual stimulus conflict based approach test concurrent presence reward aversive stimulus conclusions anhedonia like behavior sensitized behaviors natural rewards found long term morphine withdrawal notably morphine withdrawn rats displayed persistent motivated behaviors high value rewards sucrose sexual stimulus conflict tests suggesting impairments inhibitory control morphinetreated rats
green assessment tools building research establishment environmental assessment method leadership energy environmental design comprehensive assessment system building environmental efficiency green star beam used worldwide tools utilise qualitative credit based rating system several limitations firstly provide relative measure greenness facility secondly possibility ratings assigned may differ one user another depending needs priorities organisation country region several studies also highlighted credit based systems involve piece meal zuo zhou renew sustain energy rev opposed integrated evaluation green criteria greenness facility paper proposes new green index tool assessing level greenness facility overcomes aforementioned limitations use stock market composite index basis development enabled established tool assessing stock market performances progress domain industrial commercial facility management development involves two steps namely development weighting scheme using factor analysis approach followed composite formulation based stock market composite index developed green index based quantitative analysis measurement parameters hence reflect actual measure overall impact facility environment single indicator represent multiple green elements makes easier facility managers effectively quantitatively monitor analyse compare benchmark actual level greenness facilities new systems designs retrofit conservation programme
harm race based medicine inflicts minority bodies race based experimentation false solutions race based drug ensues within minority communities provokes concern areas analyze minority patient physical proxy though mind body important entities forget spirit healing physical practice includes spiritual practice efficient medicine includes holistic elements mind body spirit therefore spiritual discipline black theology used tool mend harms race based medicine avenue research particular concerns justice medical care theology contributes discussion race based medicine indicating need voice participation interdependence minorities black theology used tool healing empowerment health equity awareness exploring black theology response race based medicine analyzing race biblical literature using biblical literature tool minority patient empowerment building past current black church health advocacy personal leadership health advocacy
retrospective review pregnancies reported essure situ netherlands pregnancies included unintentional resulting lack protocol adherence misread confirmation tests intentional resulting label use essure micro inserts hydrosalpinx closure vitro fertilization intracytoplasmic sperm injection embryo transfer vitro fertilization embryo transfer regret sterilization outcomes pregnancies women micro inserts situ evaluated eight unintended pregnancies intended pregnancies resulted birth full term healthy baby seven infants delivered via cesarean section two women delivered prematurely section singleton weeks day twins weeks days babies healthy without congenital anomalies stillbirths weeks however unlikely related presence micro inserts conclusion unlikely presence intratubal micro inserts interferes implantation developing amniotic sac fetus aagl rights reserved
microstructure based modeling method developed predict mechanical behaviors lithium ion battery separators existing battery separator modeling methods capture structural features microscale overcome issue propose image based microstructure representative volume element rve modeling method facilitates understanding separators complex macro mechanical behaviors perspective microstructural features generic image processing workflow developed identify different phases microscopic image processed rve image supplies microstructural information finite element analysis fea mechanical behavior microstructure evolution obtained simulation evolution microstructure features quantified using stochastic microstructure characterization methods proposed method successfully captures anisotropic behavior separator tensile test provides insights microstructure deformation growth voids apply proposed method commercially available separator demonstration analysis results validated using experimental testing results reported literature elsevier rights reserved
key question concerns extent sexual differentiation human behavior influenced sex hormones present sensitive periods development organizational effects occurs mammalian species important sensitive period considered prenatal increasing attention puberty another organizational period possibility decreasing sensitivity sex hormones across pubertal transition paper review evidence sex hormones present prenatal pubertal periods produce permanent changes behavior good evidence exposure high levels androgens prenatal development results masculinization activity occupational interests sexual orientation spatial abilities prenatal androgens smaller effect gender identity insufficient information androgen effects sex linked behavior problems little good evidence regarding long lasting behavioral effects pubertal hormones suggestion influence gender identity perhaps sex linked forms psychopathology many opportunities study issue elsevier inc rights reserved
aim investigate clinical social correlates lifetime history crime victimization among first episode psychosis patients entry early intervention service following months specialist care methods face face interviews conducted individuals presented early intervention service first time psychosis london borough lambeth range demographic clinical measures completed including self reported history victimization along type crime subjective effect patient clinical functional outcomes month follow ascertained clinical case notes psychiatrist results large proportion patients reported history crime victimization associated significantly higher levels depression substance misuse initial presentation victim crime significantly associated poorer clinical functional outcomes months specialist care however non significant differences found reported crime victimization terms increased use illegal substances assaulted someone else follow period conclusion past experience victim crime appears common patients presenting first time psychosis associated increased likelihood comorbidity thus early intervention services consider screening past victimization prepared deal comorbid problems impact crime victimization clinical functional outcomes requires investigation longer period time
constructed channel magnetocardiography mcg system based low direct current superconducting quantum interference device squid magnetometers operated inside magnetically shielded room msr weakly damped squid magnetometers large steward mccumber parameter beta beta approximate could directly connect operational amplifier without additional feedback circuit used simplify readout electronics flux voltage transfer coefficient partial derivative partial derivative phi larger phi squid magnetometers white noise level operated msr sensing magnetometers reference magnetometers employed realize software gradiometer configurations coverage area sensing magnetometers mcg measurements high signal noise ratio done successfully using developed system
objectives non hodgkin lymphoma occurs increasing frequency hiv aids south africa highest incidence hiv aids worldwide epidemiologic study nature provides insight head neck lymphomas defined south african population retrospective review evaluated frequency clinico pathologic characteristics patients diagnosed head neck lymphoma oral pathology department university witwatersrand materials methods histopathology reports patients head neck lymphomas reviewed demographic age gender clinical site size tumour laboratory histological parameters recorded results patients head neck lymphomas mean age years male female ratio cervical lymph node common anatomic site cases maxilla cases common extranodal site plasmablastic lymphoma cases common histologic subtype seen frequently result strong association hiv aids common hodgkin lymphoma nodular sclerosing variant cases head neck lymphomas patients known hiv status plasmablastic lymphoma diffuse large cell lymphoma burkitt lymphoma conclusion increase head neck lymphoma frequency contrary found western countries high hiv prevalence certain lymphomas provides strong indication role hiv aids pathogenesis lymphomas study serves baseline future studies especially south africa elsevier ltd rights reserved
drogue detection fundamental issue close docking phase autonomous aerial refueling aar cope issue novel effective method based deep learning convolutional neural networks cnns proposed order ensure robustness wide application deep learning dataset images prepared utilizing real data probe drogue aerial refueling contains diverse drogues various environmental conditions without artificial features placed drogues employing deep learning ideas graphics processing units gpus model drogue detection using caffe deep learning framework cnns designed ensure method accuracy real time performance experiments conducted demonstrate effectiveness proposed method results based real aar data compare performance methods validating accuracy speed robustness drogue detection ability chinese society aeronautics astronautics production hosting elsevier ltd open access article license
inferring properties interaction matrix characterizes nodes networked system directly interact well known network reconstruction problem despite decade extensive studies network reconstruction remains outstanding challenge fundamental limitations governing properties interaction matrix adjacency pattern sign pattern degree sequence inferred given temporal data individual nodes remain unknown rigorously derive necessary conditions reconstruct property interaction matrix counterintuitively find reconstructing property interaction matrix generically difficult reconstructing interaction matrix requiring equally informative temporal data revealing fundamental limitations sheds light design better network reconstruction algorithms offer practical improvements existing methods
project delivery method pdm greatly influences project outcome design build construction management design bid build represent three main methods pdm comes advantages disadvantages suit different projects different circumstances general literature review case specific document study carried firstly paper identifies general criteria selecting pdm secondly comes specific criteria selecting pdm large infrastructure project due project characteristics identified specific selection criteria differ general selection criteria norwegian public roads administration npra plans coastal highway route along western coast norway covering total substituting seven ferry connections estimated cost billion norwegian kroner project used exemplary case large infrastructure project paper contributes body knowledge list selection criteria pdms aggregated literature points list adapted case specific characteristics used select pdm authors published elsevier ltd open access article license
digital pulse frequency modulated controller designed discretizing analog integral controller llc resonant converter using called pim digital redesign method regulates output voltage adjusting frequency input switching turn changes gain llc converter performances sudden changes load evaluated though extensive simulations results show digital controller realize performance analog controller sampling frequency much lower currently prevail may advantageous terms reduced computational requirements power consumption
study aging process electric motor accomplished adaptive neuro fuzzy inference system anfis using vibration signals different anfis models compared representing aging process best possible way artificial aging experiment performed vibration data taken initial healthy final faulty cases used identify aging process four different anfis models presented moving average filters applied input output pairs different lagging factors change smoothness degree data thus performance system identification success models evaluated three conditions performance anfis linear correlation expected output faulty case data aging model output time frequency domains study also evaluates influence preprocessing using filtering anfis performance vibration data stochastic characteristics
objectives recent studies identified rates injuries young elite athletes major athletic events however data exist master athletes aim study assess incidence types injuries european veteran athletics championships function age performance athletic discipline methods report forms used identify injured athletes injury types analysis included age grouped five year bands beginning age years athletic event age graded performance results athletes years participated championships women men registered injured female male athletes fractures one injury required operative treatment achilles tendon rupture injury rates significantly higher sprint middle distance jumps throws long distance decathlon heptathlon groups chi significant interrelationship age chi age graded performance chi conclusions results suggest healthy master athletes low risk injury increase age performance
attachment theories recently applied adult romantic relationships specifically sexuality within relationships however studies examined influence attachment related avoidance anxiety sexual communication gender role ideology sexual satisfaction relations constructs men women undergraduate students young adults community completed online questionnaire measuring attachment style sexual communication gender role ideology sexual satisfaction multiple mediation path analyses showed several interrelations variables among women additionally gender role ideology sexual communication together found totally mediate relation attachment related anxiety sexual satisfaction women sexual communication partially mediated relation attachment related avoidance sexual satisfaction women among men significant finding attachment related anxiety avoidance related lower sexual communication results indicate disparity sexual communication gender role ideology sexual satisfaction among individuals differing attachment orientations effects may prominent women men
interface failure pertinent composite sandwich joints high shear strength core tensile bending loads investigated experimental studies performed composite joints action tension bending indicate interface failure dominant mechanism subsequent finite element analysis reveals critical location failure initiation localized corner web adhesive interface based maximum principal stress criterion however good correlation failure load prediction finite element analysis experimental measurement obtained finite element modelling take account presence imperfections due spacer mesh voids formation poor adhesive filling neglects fixture misalignment analytical expressions peel stress interface obtained using strength materials approach critical peel stress higher numerical simulation value due redistribution peel stress presence adhesive fillet thin adhesive layer linear strain variation approximation used analytical model presented peel stress analysis also construed conservative tool design purposes
background glutaminase phosphate activated metabolic enzyme catalyzes first step glutaminolysis converts glutamine glutamate glutamate major neurotransmitter excitatory synapses executing important physiological functions central nervous system two isoforms glutaminase kga gac generated alternative splicing gene kga gac transcribe exons terminal unique terminal coding sequence previously identified kga gac differentially regulated inflammatory stimulation hiv infection furthermore glutaminase linked brain diseases amyotrophic lateral sclerosis alzheimer disease hepatic encephalopathy core enzyme structure kga gac published recently however coding sequences affect functional enzyme activity remains unclear methods cloned performed serial deletions human full length kga gac terminal terminal interval approximately amino acids aas prokaryotic expressions mutant glutaminase protein glutaminase enzyme activity assay used determine kga gac similar efficiency efficacy convert glutamine glutamate results aas aas deleted terminal unique portions kga gac beyond deleted terminal kga gac retained enzyme activity comparable full length proteins contrast deletion aas terminal deletion aas terminal resulted complete loss enzyme activity kga gac consistently nand terminal kga gac removed creating truncated protein expressed central protein retained enzyme activity furthermore expression core coding sequence cells increased extracellular glutamate concentrations levels comparable full length kga gac expressions suggesting core enzyme activity protein lies within central full length kga gac retained enzyme activities kept degrees contrast truncated protein lost glutaminase activities readily compared full length kga gac suggesting terminal terminal coding regions required stability kga gac conclusions glutaminase isoforms kga gac similar efficacy catalyze conversion glutamine glutamate core enzyme activity glutaminase protein within central terminal terminal coding regions kga gac help maintain long term activities enzymes
lithium ion battery systems employed high power demanding systems electric vehicles require sophisticated monitoring system ensure safe reliable operation three major states battery special interest need constantly monitored include battery state charge soc battery state health capcity fade determination soh state function power fade determination sof series two papers propose system algorithms based weighted recursive least quadratic squares parameter estimator able determine battery impedance diffusion parameters accurate state estimation functionality proven different battery chemistries different aging conditions first paper investigates general requirements bms hev applications parallel commonly used methods battery monitoring reviewed elaborate strength weaknesses terms identified requirements line applications special emphasis placed real time capability memory optimized code cost sensitive industrial automotive applications low cost microcontrollers must used therefore battery model presented includes influence butler volmer kinetics charge transfer process lastly mass transport process inside battery modeled novel state space representation elsevier rights reserved
aimprolonged interval related changes electrolytes haemodialysis associated cause mortality patients unknown prolonged interval associated cause mortality peritoneal dialysis patients electrolytes relatively stable therefore investigated association prolonged interval cause mortality chronic patients methodsthe intervals measured patients followed december prolonged interval defined interval association prolonged interval cause cardiac specific mortality analyzed using cox regression kaplan meier analysis resultsof patients patients prolonged interval incidence density rate per persons years cause mortality cardiac specific mortality patients prolonged interval prolonged interval associated cause mortality hazard ratio confidence interval cardiac mortality adjustments age gender diabetes vintage dialysis longer interval significantly associated worse overall survival log rank test cardiac mortality free survival log rank test conclusionsprolonged interval associated cause cardiac mortality patients peritoneal dialysis association independent patient age diabetes
objective psoriatic arthritis psa inflammatory arthropathy associated skin nail psoriasis suggested group research assessment psoriasis psoriatic arthritis grappa studies devoted assess cancer psa population still limited need increased therefore aim study determine incidence malignancies patients psa taking conventional biologic therapies methods cohort patients psa followed prospectively first visit well month followup visit according standardized clinical practice medical history physical laboratory findings recorded information presence comorbidities well malignancies collected visit data recorded radiography pathology confirming malignancy diagnosis present results total patients psa included study particular taking anti tumor necrosis factor alpha anti tnf agents taking disease modifying antirheumatic drugs dmard observation period total group patients diagnosis malignancy patient yrs received anti tnf therapy patient yrs received traditional dmard however adjusting major demographic clinical characteristics difference treatments longer significant predictor malignancy occurrence age conclusion data study confirm biological therapies lead increased risk cancer development adequately administered proper followup
two experiments preschoolers months year old children experiment experiment investigated development children resource distribution dominance contexts basis distributive justice literature opposite predictions tested children could match resource allocation unequal social setting observe thus favor dominant individual subordinate alternatively children could choose compensate subordinate consider dominance asymmetry counteracted two experiments using giving task experiment taking task experiment led results experiments children took dominance account allocating resources moreover distributive decisions similarly affected age although year old children favored dominant individual year old children showed preference year old children strongly favored subordinate several mechanisms accounting developmental pattern discussed
accumulation anecdotal accounts copycat crime suggests popular culture plays important role instances aspects criminal behavior however little empirical research specifically examining copycat effect criminal behavior questions remain regarding nature extent copycat crime cultural influences shape copycat effect role relevance popular culture motivating factor criminal behavior issues copycat phenomenon raises legal determinations criminal responsibility paper reviews research literature contemporary case examples copycat crime attention influence mass media technology criminal behavior mechanisms media mediated crime relevance understanding copycat phenomenon determinations criminal responsibility insanity cases integrative theoretical model copycat crime proposed methodological framework empirically investigating copycat crime presented practical implications understanding role copycat effect criminal behavior discussed elsevier ltd rights reserved
aims clarify effects lactobacillus gasseri quality life clinical symptoms functional mechanisms patients irritable bowel syndrome ibs methods results patients administered daily weeks ibs severity index score significantly improved compared placebo group improvement accompanied reduction health related worry changes intestinal microbiota gene expression profiling peripheral blood leucocytes showed treatment significantly regulated genes related eukaryotic initiation factor eif signalling eighty two genes regulated ibs patients compared healthy controls expression genes exhibited dependent increase associated improvement ibs severity majority restored genes related eif signalling conclusions administration potential candidate therapeutic option patients ibs significance impact study although probiotics proposed benefit ibs patients objective clinical evidence elucidation functional mechanism remain insufficient study demonstrated administration beneficially influences ibs patients subjective objective evaluations gene expression profiling provided insights functional mechanism
applied computer based text analyses regressive imagery verbal protocols individuals engaged creative problem solving two domains visual art experts novices computer programming experts novices percentages words involving primary process secondary process thought plus emotion related words tabulated visual art protocols higher primary process thought emotion related words programming higher secondary process thought almost main effects expertise interactions found correlations measures particularly involving emotion related words also varied function task pattern suggests cognitive processes vary considerably across different creative problem solving tasks domains domain specific approach creative cognition may advisable implications integrating consolidating extant lines creativity research discussed
background inconsistent staffing high turnover casual workforce problematic organisations potential impact staff services provided research primarily focused impacts inconsistent staffing child welfare community services little evidence surrounding ability impact outcomes children autism spectrum disorders attending early intervention services aim aim study explore staff views regarding impact staff turnover delivery group based early intervention children asd methods procedures conducted five focus groups involving professional teachers behaviour therapists para professional child care workers managerial staff explore views audio recordings transcribed verbatim use thematic analysis outcomes results two central themes comprising five categories emerged encompass participants views impacts staff accounted challenges existing staff felt working new untrained staff centre participants also expressed concerns impacts service delivery resulted dynamic staffing affecting fidelity interventions program conclusions implications findings suggest lacking consistent staffing structure problematic attempting provide high quality early intervention services children asd suggest future research investigate extent inconsistent staffing impacts inconsistent staffing providing intervention develop range tools help measure effects elsevier ltd rights reserved
paper novel netted radar system designed reduce influence mutual interference signals emission signals stations assigned orthogonal codes good autocorrelation cross correlation properties mutual interference becomes weaker signals different stations could separated preassigned codes time spectrum emission signal spreaded peak mean envelope power ratio pmepr intercepted probability signals descend therefore simulation results show good performance proposed approach
introduction study aimed detect early expression macrophage inducible type lectin mincle investigate role innate immune response fungal keratitis methodology wistar rats used make fungal keratitis models inflammatory responses corneal lesions observed slit lamp microscope pcr immunohistochemistry immunofluorescence used detect expression mincle rat corneal epithelium expression eight cytokines cxcl cxcl beta tnf alpha ccl ccl detected real time rtpcr immunohistochemistry lastly corneal epithelium patients aspergillus fumigatus keratitis ocular trauma patients collected detect expression mincle real time pcr ocular trauma paraffin samples collected confirm expression mincle immunohistochemistry results expression mincle significantly upregulated hours fungal infection significant differences expression eight inflammatory cytokines blank control group fungus infected group mincle expression correlated expression tnf beta ccl cornea mrna expressions mincle corneas normal patients significantly different conclusions expression mincle increases significantly early period aspergillus fumigatus infection expression eight corresponding cytokines changes mincle pattern recognition receptor may play role early innate immune response corneal resistance fungus
closed loop geometry based optimization method developed work integrating subdivision reanalysis metaheuristic searching techniques purpose subdivision surfaces using triangle meshes simultaneously applied cad computer aided design modeling cae computer aided engineering analysis framework feature objects defined subdivision model subdivision models controlled geometric parameters global optimization metaheuristic algorithms performed independent coefficients reanalysis method introduced enhance efficiency optimization order improve accuracy triangular meshes fem edge based smoothed finite element method technique employed analysis work proposed approach successfully tested three real engineering geometry optimization problems elsevier ltd rights reserved
article prolongation structure technique applied generalised inhomogeneous gardner equation used describe certain physical situations stratified shear flows ocean atmosphere ion acoustic waves plasmas negative ion interfacial solitary waves slowly varying topographies wave motion non linear elastic structural element large deflection lax pairs derived via prolongation structure general lax pairs published painleve conditions linear damping coefficient equals zero quadratic non linear coefficient proportional dispersive coefficient cubic non linear coefficient proportional leaving constraints dissipative coefficient establish prolongation structure constructing exterior differential system introduce two methods obtain lax pairs based prolongation structure lax pairs obtained via lie algebra derive pfaffian forms lax pairs certain parameters chosen set constant discuss influence pfaffian forms lax pairs discuss influence pfaffian forms lax pairs set another constant get different prolongation structure pfaffian forms lax pairs
compared effects item specific versus relational encoding recognition memory deese roediger mcdermott paradigm experiment directly compared item specific relational encoding instructions whereas experiments biased pleasantness generation tasks respectively toward one type processing read condition tested experiment comparison purposes across experiments item specific relational encoding boosted correct recognition relative reading item specific encoding typically reduced false recognition signal detection measures revealed less information encoded critical items item specific relational encoding contrast item specific relational encoding led equivalent increases strategic monitoring test use distinctiveness heuristic thus monitoring test less successful relational item specific encoding information encoded critical lures
study current sharing bus fuzzy gain scheduling proportional integral controller control parallel connected converter proposed simple current sharing circuit applied divide load current calculate peak input current converter module fuzzy gain scheduling controller used compensate error output voltage dspicf microcontroller applied voltage loop control addition hysteresis control circuit used control current loop experimental performance evaluation conducted prototype three converter modules parallel connected module output voltage system offers following advantages tight output voltage regulates steady state operation transient response current sharing quite good simpler operate redundant mode
since influence temperature conversion efficiencies photovoltaic cells thermoelectric generators totally different opposite system operating temperature becomes key parameter significantly determines utilization efficiency common system solar energy order make system obtain higher energy utilization efficiency phase change material pcm incorporated construct novel pcm hybrid system maintain system operating ideal working temperature performance novel hybrid system experirnentally studied corresponding number practical working conditions temperature efficiency output power hybrid system compared pure system circumstance effects optical concentrations ratio cooling approaches conversion efficiency hybrid system experimentally investigated whole conversion efficiencies hybrid system incorporated generators different values dimensionless thermoelectric coefficient discussed present work reveals hybrid system possesses promising potential full spectrum utilization solar energy elsevier ltd rights reserved
recent years much research focused attention ambient intelligence ami potential applications smart homes hospitals health monitoring daily life assistance make paradigm promising field research great positive impact lives combination ami environments multi agent systems mas emerged perfect solution development kind applications however many challenges addressed applications put practice paper propose architecture based mas aimed build rehabilitation systems people acquired brain injury abi explain architecture applied development smart system defining planning therapies people abi control evaluate rehabilitation process
background growing number countries legislate nurses medication prescribing authority although contested issue one countries giving authority nurses additional qualifications since incrementally widened scope nurse prescribing recently policy intention primary care improve efficiency service delivery flexibility medical nursing roles extent occurred uncertain study investigated nurses prescribing activities time english primary care settings methods secondary data analysis national primary care prescription database national health service workforce database undertaken results numbers nurses issuing one prescription annually primary care rose represented forty three percent prescribing qualifications authorisation employers number items prescribed nurses rose total items prescribed primary care greatest volume items prescribed independent nurse prescribers category penicillins followed dressings however category independent nurse prescribers contributed largest proportion primary care prescriptions emergency contraception contrast community practitioner nurse prescribers greatest volume contribution category gel colloid dressings medicated stockings incontinence appliances slightly higher rates nurse prescribing areas higher levels socio economic deprivation fewer physicians per capita correlations weak warrant investigation conclusions percentage prescriptions written nurses primary care england small comparison physicians findings suggest nurse prescribing used seen relative advantage stakeholders particular supports efficiency nursing practice also health promotion activities nurses general practice areas appears flexibility prescribing role nurses general practitioners
randomized line algorithm given competitiveness less previously best known competitiveness uses new approach defines potential server problem line oblivious adversary improves approximate problem algorithm terms isolation indices theory elsevier rights reserved
background objective various digital pathology tools developed aid analyzing tissues improving cancer pathology multi resolution nature cancer pathology however fully analyzed utilized develop automated cooperative multi resolution method improving prostate cancer diagnosis methods digitized tissue specimen images obtained tissue microarrays tmas tmas include benign cancer samples tma benign cancer samples tma benign cancer samples tma benign cancer samples tma benign cancer samples tma tissue specimen images segmented using intensity texture based features using segmentation results number morphological features lumens epithelial nuclei computed characterize tissues different resolutions applying multiview boosting algorithm tissue characteristics obtained differing resolutions cooperatively combined achieve accurate cancer detection results segmenting prostate tissues multiview boosting method achieved auc using tma detecting cancers multiview boosting method achieved auc trained tma tested tma tma tma proposed method superior single view approaches utilizing features single resolution merging features resolutions moreover performance proposed method insensitive choice training dataset trained tma tma tma proposed method obtained auc respectively conclusions multiview boosting method capable integrating information multiple resolutions effective efficient fashion identifying cancers high accuracy multiview boosting method holds great potential improving digital pathology tools research elsevier rights reserved
intervention strategies familial adenomatous polyposis fap patients high risk colorectal cancer crc populations highlighted critical need endoscopy combined safe effective preventive agents performed transcriptome profiling colorectal adenomas fap patients polyposis rat colon pirc preclinical model prioritized molecular targets prevention studies vivo clinically relevant doses pirc model drug clotam tolfenamic acid highly effective suppressing tumorigenesis colon small intestine administered alone combination sulindac cell proliferation colonic crypts reduced significantly coincident increased cleaved caspase decreased survivin beta catenin cyclin matrix metalloproteinase list differentially expressed genes prioritized transcriptome profiling mmp nppb aldha defined key oncogene candidates downregulated colon tumors treatment monthly colonoscopies revealed rapid onset tumor suppression pirc model temporal changes mmp nppb aldha highlighting value potential early biomarkers prevention clinical setting conclude old drug repurposed migraine offers exciting new therapeutic avenue fap high risk crc patient populations
background study examined whether starting buprenorphine treatment prior prison release prison would associated better drug treatment outcomes whether males females responded differently combination prison treatment post release service setting methods study design prison treatment condition buprenorphine treatment counseling post release service setting condition opioid treatment program otp community health center chc gender factorial design trial conducted september july follow assessments completed participants recruited two baltimore pre release prisons one men one women adult pre release prisoners heroin dependent year prior incarceration eligible post release assessments conducted month following prison release results participants prison treatment condition effect higher mean number days community buprenorphine treatment compared condition participants initiated medication release however statistically significant hypothesized effects prison treatment condition terms days heroin use crime opioid cocaine positive urine screening test results statistically significant hypothesized gender effects conclusions although initiating buprenorphine treatment prison compared release associated days receiving buprenorphine treatment designated community treatment program months post release assessment associated superior outcomes terms heroin cocaine use criminal behavior elsevier rights reserved
excess consumption energy humans compounded environmental pollution greenhouse effect climate change impacts current developments use algae bioenergy production offer several advantages algal biomass hence considered new bio material holds promise fulfil rising demand energy microalgae used effluents treatment bioenergy production high value added products synthesis capture review summarizes potential applications algae bioelectrochemically mediated oxidation reactions fully biotic microbial fuel cells power generation removal unwanted nutrients addition review highlights recent developments directed towards developing different types microalgae mfcs different process factors affecting performance microalgae mfc system technological bottlenecks also addressed elsevier ltd rights reserved
prevalence frequency psychosocial predictors internet computer game use assessed male female adolescents across time periods months apart time participants grade time grade girls boys reported using internet time periods whereas boys girls reported gaming time periods girls reported small decrease time frequency hours spent per day overall technology use mostly due decrease gaming linear curvilinear relations examined parental relationships friendship quality academic orientation well measured early high school frequency technology use late high school male significantly predicted computer gaming internet use also trends favor higher friendship quality less positive parental relationships predicting higher frequency internet use importantly moderate use internet associated positive academic orientation nonuse high levels use
resistant hypertension defined blood pressure despite using antihypertensive medications well recognized clinical entity patients resistant hypertension increased risk cardiovascular disease compared easily controlled hypertension coronary heart disease mortality rates younger adults stagnating rise purpose study characterize phenotype risk factors younger patients resistant hypertension given dearth data cardiovascular risk profile cohort conducted cross sectional analysis predefined age groups large ethnically diverse cohort patients referred hypertension clinic university alabama birmingham patients met inclusion criteria classified age groups years patients aged years significantly earlier onset hypertension versus years higher rates obesity versus significantly higher levels plasma aldosterone versus plasma renin activity versus per hour hour urinary aldosterone versus sodium excretion versus meq among patients resistant hypertension younger individuals distinct phenotype characterized overlapping risk factors comorbidities including obesity high aldosterone high dietary sodium intake compared elderly
mesochronic velocity average velocity field along trajectories generated velocity field time interval finite duration paper classify initial conditions trajectories evolving incompressible vector fields according character motion material around trajectory particular provide calculations used determine number expanding directions presence rotation characteristic polynomial jacobian matrix mesochronic velocity show mesochronic velocity used characterize dynamical deformation three dimensional volumes resulting mesochronic analysis finite time extension okubo weiss chong analysis incompressible velocity fields two dimensional mesochronic analysis mezic new mixing diagnostic gulf oil spill movement science extends three dimensional state spaces theoretical considerations supported numerical computations performed dynamical system arising fluid mechanics unsteady arnold beltrami childress abc flow
